Gene	Bud31_sh1_1	Bud31_sh1_2	Bud31_sh1_3	786O_WT_1	786O_WT_2	786O_WT_3	logFC	logCPM	PValue	FDR	GeneInfo	GeneName	GO	KEGG	NR
ENSG00000106245	65.91	73.22	66.88	244.63	217.22	227.87	-1.73596531993477	6.0759881418478	2.95612406433313e-120	3.66943680105671e-116	7:99408640-99419616:+	BUD31	11;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000790,cellular_component nuclear chromatin;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0035257,molecular_function nuclear hormone receptor binding;GO:2000825,biological_process positive regulation of androgen receptor activity	BUD31, G10; bud site selection protein 31; K12873	BUD31 homolog [Source:HGNC Symbol%3BAcc:HGNC:29629]
ENSG00000154175	8.62	8.74	9.15	4.07	4.19	4.11	1.11204518057938	5.16193094943959	1.3784244663869e-51	8.55519145063031e-48	3:100749155-100993515:-	ABI3BP	10;GO:0005518,molecular_function collagen binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005614,cellular_component interstitial matrix;GO:0005615,cellular_component extracellular space;GO:0008201,molecular_function heparin binding;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix	NA	ABI family member 3 binding protein [Source:HGNC Symbol%3BAcc:HGNC:17265]
ENSG00000000971	107.16	104.60	109.15	34.26	47.87	39.56	1.41079989441102	8.09613656346132	5.47122992848748e-49	2.26381257007717e-45	1:196651877-196747504:+	CFH	12;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006956,biological_process complement activation;GO:0006957,biological_process complement activation, alternative pathway;GO:0008201,molecular_function heparin binding;GO:0030449,biological_process regulation of complement activation;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	CFH, HF1; complement factor H; K04004	complement factor H [Source:HGNC Symbol%3BAcc:HGNC:4883]
ENSG00000120053	113.38	109.06	116.13	186.36	175.13	184.05	-0.675688317944719	7.51505063003517	1.01457305754502e-27	3.14847384082659e-24	10:99396869-99430624:-	GOT1	34;GO:0003824,molecular_function catalytic activity;GO:0004069,molecular_function L-aspartate:2-oxoglutarate aminotransferase activity;GO:0004609,molecular_function phosphatidylserine decarboxylase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006094,biological_process gluconeogenesis;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006114,biological_process glycerol biosynthetic process;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006531,biological_process aspartate metabolic process;GO:0006532,biological_process aspartate biosynthetic process;GO:0006533,biological_process aspartate catabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0007219,biological_process Notch signaling pathway;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0019550,biological_process glutamate catabolic process to aspartate;GO:0019551,biological_process glutamate catabolic process to 2-oxoglutarate;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0031406,molecular_function carboxylic acid binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0043648,biological_process dicarboxylic acid metabolic process;GO:0043679,cellular_component axon terminus;GO:0047801,molecular_function L-cysteine:2-oxoglutarate aminotransferase activity;GO:0051384,biological_process response to glucocorticoid;GO:0055089,biological_process fatty acid homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0080130,molecular_function L-phenylalanine:2-oxoglutarate aminotransferase activity	GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]; K14454	glutamic-oxaloacetic transaminase 1 [Source:HGNC Symbol%3BAcc:HGNC:4432]
ENSG00000105472	14.50	13.52	13.95	6.03	5.51	6.08	1.26459323449759	3.34912549610001	7.51587740334103e-26	1.86589172415344e-22	19:50723328-50725718:+	CLEC11A	7;GO:0001503,biological_process ossification;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0030246,molecular_function carbohydrate binding	NA	C-type lectin domain containing 11A [Source:HGNC Symbol%3BAcc:HGNC:10576]
ENSG00000101955	37.04	34.26	37.86	21.84	20.16	22.23	0.779213211020898	5.33389392148702	9.14205830712442e-26	1.89133949610559e-22	X:38149335-38220924:-	SRPX	10;GO:0001845,biological_process phagolysosome assembly;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0006914,biological_process autophagy;GO:0007155,biological_process cell adhesion;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0060244,biological_process negative regulation of cell proliferation involved in contact inhibition;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	sushi repeat containing protein%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:11309]
ENSG00000047457	43.29	39.81	42.92	25.32	26.91	27.28	0.677538037482401	6.87290754436734	5.85282318759434e-25	1.03787277468012e-21	3:149162409-149222055:-	CP	19;GO:0004322,molecular_function ferroxidase activity;GO:0005507,molecular_function copper ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005765,cellular_component lysosomal membrane;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006825,biological_process copper ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0016491,molecular_function oxidoreductase activity;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	CP; ceruloplasmin [EC:1.16.3.1]; K13624	ceruloplasmin [Source:HGNC Symbol%3BAcc:HGNC:2295]
ENSG00000129988	22.71	21.85	24.38	12.04	12.04	13.69	0.880881138121006	4.68665694976078	1.24977815581721e-23	1.93918703101988e-20	20:38346355-38377023:+	LBP	44;GO:0001530,molecular_function lipopolysaccharide binding;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002232,biological_process leukocyte chemotaxis involved in inflammatory response;GO:0002281,biological_process macrophage activation involved in immune response;GO:0002376,biological_process immune system process;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006953,biological_process acute-phase response;GO:0006968,biological_process cellular defense response;GO:0008228,biological_process opsonization;GO:0008289,molecular_function lipid binding;GO:0009986,cellular_component cell surface;GO:0015920,biological_process lipopolysaccharide transport;GO:0016020,cellular_component membrane;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032490,biological_process detection of molecule of bacterial origin;GO:0032496,biological_process response to lipopolysaccharide;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032722,biological_process positive regulation of chemokine production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0033036,biological_process macromolecule localization;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0042535,biological_process positive regulation of tumor necrosis factor biosynthetic process;GO:0042742,biological_process defense response to bacterium;GO:0043032,biological_process positive regulation of macrophage activation;GO:0044130,biological_process negative regulation of growth of symbiont in host;GO:0045087,biological_process innate immune response;GO:0045919,biological_process positive regulation of cytolysis;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0060265,biological_process positive regulation of respiratory burst involved in inflammatory response;GO:0070062,cellular_component extracellular exosome;GO:0070891,molecular_function lipoteichoic acid binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071223,biological_process cellular response to lipoteichoic acid;GO:0071723,molecular_function lipopeptide binding;GO:0090023,biological_process positive regulation of neutrophil chemotaxis	LBP; lipopolysaccharide-binding protein; K05399	lipopolysaccharide binding protein [Source:HGNC Symbol%3BAcc:HGNC:6517]
ENSG00000182326	13.21	14.36	13.67	7.12	8.37	7.24	0.868954407014367	4.60574635677536	4.53485419108851e-22	6.25457167488685e-19	12:6988258-7071032:+	C1S	18;GO:0001867,biological_process complement activation, lectin pathway;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0006508,biological_process proteolysis;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030449,biological_process regulation of complement activation;GO:0042802,molecular_function identical protein binding;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	C1S; complement component 1, s subcomponent [EC:3.4.21.42]; K01331	complement C1s [Source:HGNC Symbol%3BAcc:HGNC:1247]
ENSG00000077420	49.24	48.55	50.00	33.31	33.85	34.22	0.555712888525988	6.42162171469693	3.54013244390207e-19	4.39436640261564e-16	10:26438202-26567803:+	APBB1IP	14;GO:0002291,biological_process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0042101,cellular_component T cell receptor complex;GO:0042995,cellular_component cell projection;GO:0045785,biological_process positive regulation of cell adhesion	NA	amyloid beta precursor protein binding family B member 1 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:17379]
ENSG00000101825	8.08	8.41	7.77	4.82	5.61	4.70	0.692685805603825	5.80057995022565	4.01003955351652e-19	4.52514736161823e-16	X:3308564-3346641:-	MXRA5	5;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome;GO:0071559,biological_process response to transforming growth factor beta	NA	matrix remodeling associated 5 [Source:HGNC Symbol%3BAcc:HGNC:7539]
ENSG00000095485	31.02	32.51	30.60	47.46	45.16	47.18	-0.561294797702227	5.9816447286951	3.38085483450036e-18	3.49721258838774e-15	10:100232297-100267680:-	CWF19L1	4;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	CWF19 like 1%2C cell cycle control (S. pombe) [Source:HGNC Symbol%3BAcc:HGNC:25613]
ENSG00000014919	41.46	43.24	41.95	61.67	63.76	60.31	-0.541950179114162	6.0785510648687	4.44915417501415e-17	4.24825775188082e-14	10:99711843-99732100:-	COX15	18;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0006783,biological_process heme biosynthetic process;GO:0006784,biological_process heme a biosynthetic process;GO:0007585,biological_process respiratory gaseous exchange;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0031966,cellular_component mitochondrial membrane;GO:0045333,biological_process cellular respiration;GO:0055114,biological_process oxidation-reduction process;GO:0070069,cellular_component cytochrome complex;GO:1902600,biological_process hydrogen ion transmembrane transport	COX15, ctaA; cytochrome c oxidase assembly protein subunit 15; K02259	COX15%2C cytochrome c oxidase assembly homolog [Source:HGNC Symbol%3BAcc:HGNC:2263]
ENSG00000224389	4.13	4.00	4.57	2.18	2.45	2.58	0.831374294094204	4.12613831832463	3.87786754423801e-16	3.43828355904475e-13	6:32014761-32035418:+	C4B	26;GO:0001848,molecular_function complement binding;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006954,biological_process inflammatory response;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0008228,biological_process opsonization;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030054,cellular_component cell junction;GO:0030246,molecular_function carbohydrate binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030449,biological_process regulation of complement activation;GO:0032490,biological_process detection of molecule of bacterial origin;GO:0042995,cellular_component cell projection;GO:0044216,cellular_component other organism cell;GO:0045087,biological_process innate immune response;GO:0045202,cellular_component synapse;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle;GO:2000427,biological_process positive regulation of apoptotic cell clearance	C4; complement component 4; K03989	complement C4B (Chido blood group) [Source:HGNC Symbol%3BAcc:HGNC:1324]
ENSG00000242366	57.21	60.04	61.70	34.52	43.45	37.55	0.643323271244653	6.28749282865897	1.29598838062759e-15	1.07247358458202e-12	2:233617644-233773310:+	UGT1A8	26;GO:0001972,molecular_function retinoic acid binding;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005496,molecular_function steroid binding;GO:0005504,molecular_function fatty acid binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006631,biological_process fatty acid metabolic process;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0009804,biological_process coumarin metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0042573,biological_process retinoic acid metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045922,biological_process negative regulation of fatty acid metabolic process;GO:0045939,biological_process negative regulation of steroid metabolic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0051552,biological_process flavone metabolic process;GO:0052696,biological_process flavonoid glucuronidation;GO:0052697,biological_process xenobiotic glucuronidation	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 1 member A8 [Source:HGNC Symbol%3BAcc:HGNC:12540]
ENSG00000196159	2.59	2.28	2.47	1.43	1.69	1.45	0.704916931671284	4.90760161153371	1.78770795757193e-15	1.26034026945233e-12	4:125316398-125492932:+	FAT4	26;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001822,biological_process kidney development;GO:0003007,biological_process heart morphogenesis;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007009,biological_process plasma membrane organization;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007219,biological_process Notch signaling pathway;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021987,biological_process cerebral cortex development;GO:0022008,biological_process neurogenesis;GO:0035329,biological_process hippo signaling;GO:0043931,biological_process ossification involved in bone maturation;GO:0045177,cellular_component apical part of cell;GO:0048565,biological_process digestive tract development;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0070062,cellular_component extracellular exosome;GO:0072006,biological_process nephron development;GO:0072137,biological_process condensed mesenchymal cell proliferation;GO:0072307,biological_process regulation of metanephric nephron tubule epithelial cell differentiation	FAT4; protocadherin Fat 4; K16669	FAT atypical cadherin 4 [Source:HGNC Symbol%3BAcc:HGNC:23109]
ENSG00000071575	6.82	7.12	7.11	3.25	3.23	2.93	1.17084260881521	2.65242594550842	1.8197280205719e-15	1.26034026945233e-12	2:12716888-12742734:+	TRIB2	16;GO:0004672,molecular_function protein kinase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008134,molecular_function transcription factor binding;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043405,biological_process regulation of MAP kinase activity;GO:0045081,biological_process negative regulation of interleukin-10 biosynthetic process;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0055106,molecular_function ubiquitin-protein transferase regulator activity	NA	tribbles pseudokinase 2 [Source:HGNC Symbol%3BAcc:HGNC:30809]
ENSG00000196549	18.73	18.73	20.08	12.97	13.36	12.36	0.586142846956515	5.22546851604247	1.84217593423343e-15	1.26034026945233e-12	3:155024123-155183729:+	MME	36;GO:0001822,biological_process kidney development;GO:0002003,biological_process angiotensin maturation;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005903,cellular_component brush border;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006518,biological_process peptide metabolic process;GO:0008021,cellular_component synaptic vesicle;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008238,molecular_function exopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019233,biological_process sensory perception of pain;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030667,cellular_component secretory granule membrane;GO:0042277,molecular_function peptide binding;GO:0043312,biological_process neutrophil degranulation;GO:0044306,cellular_component neuron projection terminus;GO:0045202,cellular_component synapse;GO:0046449,biological_process creatinine metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050435,biological_process beta-amyloid metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071492,biological_process cellular response to UV-A;GO:0071493,biological_process cellular response to UV-B;GO:0090399,biological_process replicative senescence	MME, CD10; neprilysin [EC:3.4.24.11]; K01389	membrane metalloendopeptidase [Source:HGNC Symbol%3BAcc:HGNC:7154]
ENSG00000099139	7.54	8.89	7.43	11.96	14.05	12.37	-0.678198330634519	5.95637749344187	1.92914405217065e-15	1.26034026945233e-12	9:75890643-76362339:+	PCSK5	38;GO:0001822,biological_process kidney development;GO:0002001,biological_process renin secretion into blood stream;GO:0003279,biological_process cardiac septum development;GO:0004175,molecular_function endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0007267,biological_process cell-cell signaling;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0007565,biological_process female pregnancy;GO:0007566,biological_process embryo implantation;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009952,biological_process anterior/posterior pattern specification;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016486,biological_process peptide hormone processing;GO:0016787,molecular_function hydrolase activity;GO:0019058,biological_process viral life cycle;GO:0030141,cellular_component secretory granule;GO:0030323,biological_process respiratory tube development;GO:0032455,biological_process nerve growth factor processing;GO:0035108,biological_process limb morphogenesis;GO:0042089,biological_process cytokine biosynthetic process;GO:0042277,molecular_function peptide binding;GO:0043043,biological_process peptide biosynthetic process;GO:0048566,biological_process embryonic digestive tract development;GO:0048706,biological_process embryonic skeletal system development;GO:0051004,biological_process regulation of lipoprotein lipase activity;GO:0060976,biological_process coronary vasculature development	NA	proprotein convertase subtilisin/kexin type 5 [Source:HGNC Symbol%3BAcc:HGNC:8747]
ENSG00000151632	12.01	10.99	11.29	4.42	6.49	5.05	1.12004505038764	3.10602615574697	6.46448090727825e-15	4.01218007510224e-12	10:4987399-5018031:-	AKR1C2	23;GO:0004032,molecular_function alditol:NADP+ 1-oxidoreductase activity;GO:0005737,cellular_component cytoplasm;GO:0006629,biological_process lipid metabolic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007586,biological_process digestion;GO:0008202,biological_process steroid metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016491,molecular_function oxidoreductase activity;GO:0016655,molecular_function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636,molecular_function phenanthrene 9,10-monooxygenase activity;GO:0030855,biological_process epithelial cell differentiation;GO:0031406,molecular_function carboxylic acid binding;GO:0032052,molecular_function bile acid binding;GO:0042448,biological_process progesterone metabolic process;GO:0044597,biological_process daunorubicin metabolic process;GO:0044598,biological_process doxorubicin metabolic process;GO:0047086,molecular_function ketosteroid monooxygenase activity;GO:0047115,molecular_function trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0055114,biological_process oxidation-reduction process;GO:0071395,biological_process cellular response to jasmonic acid stimulus;GO:0071799,biological_process cellular response to prostaglandin D stimulus	AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]; K00089	aldo-keto reductase family 1 member C2 [Source:HGNC Symbol%3BAcc:HGNC:385]
ENSG00000143341	0.28	0.29	0.30	0.08	0.12	0.07	1.69114875959002	1.72828605555196	9.68699705725339e-15	5.72593783198506e-12	1:185734550-186190949:+	HMCN1	15;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005737,cellular_component cytoplasm;GO:0005938,cellular_component cell cortex;GO:0007049,biological_process cell cycle;GO:0007601,biological_process visual perception;GO:0030054,cellular_component cell junction;GO:0031012,cellular_component extracellular matrix;GO:0032154,cellular_component cleavage furrow;GO:0050896,biological_process response to stimulus;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome	NA	hemicentin 1 [Source:HGNC Symbol%3BAcc:HGNC:19194]
ENSG00000052749	14.49	12.76	13.36	20.40	18.87	20.31	-0.538131797039911	6.05708786911566	1.11552360693878e-14	6.29408842405958e-12	10:97356357-97426076:-	RRP12	6;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane	NA	ribosomal RNA processing 12 homolog [Source:HGNC Symbol%3BAcc:HGNC:29100]
ENSG00000244731	6.28	5.11	6.06	2.83	3.39	3.70	0.83063543973437	4.58649017763329	1.91699381394309e-14	1.03459322662937e-11	6:31982023-32002681:+	C4A	26;GO:0001849,molecular_function complement component C1q binding;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006954,biological_process inflammatory response;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030449,biological_process regulation of complement activation;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045087,biological_process innate immune response;GO:0045202,cellular_component synapse;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle;GO:2000427,biological_process positive regulation of apoptotic cell clearance	C4; complement component 4; K03989	complement C4A (Rodgers blood group) [Source:HGNC Symbol%3BAcc:HGNC:1323]
ENSG00000172296	25.48	28.37	27.82	17.44	18.47	19.31	0.572936482811621	5.36065773151503	2.19364435417012e-14	1.13457114034641e-11	20:13008978-13169103:+	SPTLC3	17;GO:0003824,molecular_function catalytic activity;GO:0004758,molecular_function serine C-palmitoyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008483,molecular_function transaminase activity;GO:0009058,biological_process biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017059,cellular_component serine C-palmitoyltransferase complex;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0046520,biological_process sphingoid biosynthetic process	SPT; serine palmitoyltransferase [EC:2.3.1.50]; K00654	serine palmitoyltransferase long chain base subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:16253]
ENSG00000049323	1.06	0.59	1.16	0.24	0.12	0.22	2.2952784544464	1.63337013636585	5.07101324776818e-14	2.51785949778186e-11	2:32946971-33399509:+	LTBP1	20;GO:0001527,cellular_component microfibril;GO:0003281,biological_process ventricular septum development;GO:0005024,molecular_function transforming growth factor beta-activated receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0019838,molecular_function growth factor binding;GO:0031012,cellular_component extracellular matrix;GO:0035583,biological_process sequestering of TGFbeta in extracellular matrix;GO:0035904,biological_process aorta development;GO:0043234,cellular_component protein complex;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0050431,molecular_function transforming growth factor beta binding;GO:0050436,molecular_function microfibril binding;GO:0060976,biological_process coronary vasculature development	NA	latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6714]
ENSG00000124212	5.13	5.73	5.15	11.18	9.10	10.45	-0.935510568930875	3.57456126930871	6.82869846818092e-14	3.26017823405883e-11	20:49503873-49568146:-	PTGIS	37;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005901,cellular_component caveola;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006690,biological_process icosanoid metabolic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0007566,biological_process embryo implantation;GO:0008116,molecular_function prostaglandin-I synthase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016853,molecular_function isomerase activity;GO:0019371,biological_process cyclooxygenase pathway;GO:0020037,molecular_function heme binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0035360,biological_process positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046697,biological_process decidualization;GO:0046872,molecular_function metal ion binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0055114,biological_process oxidation-reduction process;GO:0071347,biological_process cellular response to interleukin-1;GO:0071354,biological_process cellular response to interleukin-6;GO:0071456,biological_process cellular response to hypoxia;GO:0097190,biological_process apoptotic signaling pathway;GO:1900119,biological_process positive regulation of execution phase of apoptosis	PTGIS, CYP8A; prostacyclin synthase [EC:5.3.99.4]; K01831	prostaglandin I2 synthase [Source:HGNC Symbol%3BAcc:HGNC:9603]
ENSG00000106541	10.06	12.98	11.56	3.55	3.85	5.41	1.42503009563252	2.29064289652679	9.84682898013696e-14	4.52698844927556e-11	7:16791810-16833433:-	AGR2	20;GO:0002162,molecular_function dystroglycan binding;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0010628,biological_process positive regulation of gene expression;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0030154,biological_process cell differentiation;GO:0042803,molecular_function protein homodimerization activity;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0048546,biological_process digestive tract morphogenesis;GO:0048639,biological_process positive regulation of developmental growth;GO:0060480,biological_process lung goblet cell differentiation;GO:0060548,biological_process negative regulation of cell death;GO:0070254,biological_process mucus secretion;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response;GO:1903899,biological_process positive regulation of PERK-mediated unfolded protein response	NA	anterior gradient 2%2C protein disulphide isomerase family member [Source:HGNC Symbol%3BAcc:HGNC:328]
ENSG00000166135	47.15	50.29	50.19	71.08	67.01	70.39	-0.487871557487448	5.96345738600118	1.06076097607008e-13	4.70258071284212e-11	10:100529071-100559998:+	HIF1AN	33;GO:0005112,molecular_function Notch binding;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0019826,molecular_function oxygen sensor activity;GO:0031406,molecular_function carboxylic acid binding;GO:0036138,biological_process peptidyl-histidine hydroxylation;GO:0036139,molecular_function peptidyl-histidine dioxygenase activity;GO:0036140,molecular_function peptidyl-asparagine 3-dioxygenase activity;GO:0042264,biological_process peptidyl-aspartic acid hydroxylation;GO:0042265,biological_process peptidyl-asparagine hydroxylation;GO:0042803,molecular_function protein homodimerization activity;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0048037,molecular_function cofactor binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051059,molecular_function NF-kappaB binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061428,biological_process negative regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0071532,molecular_function ankyrin repeat binding;GO:0102113,molecular_function hypoxia-inducible factor-asparagine oxygenase activity;GO:2001214,biological_process positive regulation of vasculogenesis	ASPH; aspartate beta-hydroxylase [EC:1.14.11.16]; K00476	hypoxia inducible factor 1 alpha subunit inhibitor [Source:HGNC Symbol%3BAcc:HGNC:17113]
ENSG00000105699	20.46	19.14	19.51	28.80	27.58	28.03	-0.499965381998403	5.55007815442338	1.20832328350029e-13	5.17204031658244e-11	19:35248329-35267964:+	LSR	13;GO:0001889,biological_process liver development;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0034361,cellular_component very-low-density lipoprotein particle;GO:0034362,cellular_component low-density lipoprotein particle;GO:0042627,cellular_component chylomicron;GO:0060856,biological_process establishment of blood-brain barrier;GO:0061689,cellular_component tricellular tight junction;GO:0061833,biological_process protein localization to tricellular tight junction;GO:0070062,cellular_component extracellular exosome;GO:1904274,biological_process tricellular tight junction assembly	NA	lipolysis stimulated lipoprotein receptor [Source:HGNC Symbol%3BAcc:HGNC:29572]
ENSG00000196358	5.80	5.14	6.09	2.74	2.36	3.12	1.06477000091499	2.94686779711275	2.21337852044764e-13	9.1457619464505e-11	9:132161675-132244534:+	NTNG2	13;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0031225,cellular_component anchored component of membrane;GO:0046658,cellular_component anchored component of plasma membrane	NTNG2; netrin-G2; K16359	netrin G2 [Source:HGNC Symbol%3BAcc:HGNC:14288]
ENSG00000107816	72.46	71.33	76.39	100.69	98.74	104.13	-0.451002584899245	7.45543981109295	2.28404592233921e-13	9.1457619464505e-11	10:100996617-101007836:+	LZTS2	17;GO:0001822,biological_process kidney development;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016055,biological_process Wnt signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0031982,cellular_component vesicle;GO:0051301,biological_process cell division;GO:0072001,biological_process renal system development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1900181,biological_process negative regulation of protein localization to nucleus	NA	leucine zipper tumor suppressor 2 [Source:HGNC Symbol%3BAcc:HGNC:29381]
ENSG00000159403	13.20	12.57	13.79	8.19	8.68	9.05	0.623718640524581	4.57079730122054	2.81881886824801e-13	1.0897374176136e-10	12:7080208-7092607:-	C1R	18;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006955,biological_process immune response;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030449,biological_process regulation of complement activation;GO:0031638,biological_process zymogen activation;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	C1R; complement component 1, r subcomponent [EC:3.4.21.41]; K01330	complement C1r [Source:HGNC Symbol%3BAcc:HGNC:1246]
ENSG00000132182	0.99	1.06	0.86	1.93	1.81	2.06	-0.994970944449174	3.07549213150253	2.89707039243121e-13	1.0897374176136e-10	3:13316234-13420309:-	NUP210	23;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0046983,molecular_function protein dimerization activity;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP210, GP210; nuclear pore complex protein Nup210; K14314	nucleoporin 210 [Source:HGNC Symbol%3BAcc:HGNC:30052]
ENSG00000146038	73.72	75.17	67.88	97.32	116.22	106.28	-0.549987401030088	7.18226263040737	4.38460200262371e-13	1.60076660760495e-10	6:24171755-24358052:-	DCDC2	20;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006968,biological_process cellular defense response;GO:0007399,biological_process nervous system development;GO:0007605,biological_process sensory perception of sound;GO:0030030,biological_process cell projection organization;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0060091,cellular_component kinocilium;GO:0060271,biological_process cilium morphogenesis;GO:1902017,biological_process regulation of cilium assembly	NA	doublecortin domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18141]
ENSG00000152580	0.45	0.60	0.63	0.22	0.13	0.13	1.80195363233691	1.56501225012444	6.37962994647786e-13	2.26258132930371e-10	3:151425383-151458709:-	IGSF10	5;GO:0001503,biological_process ossification;GO:0005576,cellular_component extracellular region;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:2001222,biological_process regulation of neuron migration	NA	immunoglobulin superfamily member 10 [Source:HGNC Symbol%3BAcc:HGNC:26384]
ENSG00000151067	0.94	0.80	0.85	0.43	0.30	0.35	1.28341519906226	2.23827419264277	1.33969997088615e-12	4.61935992739162e-10	12:1970785-2697950:+	CACNA1C	43;GO:0002520,biological_process immune system development;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007507,biological_process heart development;GO:0008331,molecular_function high voltage-gated calcium channel activity;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030018,cellular_component Z disc;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035585,biological_process calcium-mediated signaling using extracellular calcium source;GO:0043010,biological_process camera-type eye development;GO:0046872,molecular_function metal ion binding;GO:0050796,biological_process regulation of insulin secretion;GO:0051393,molecular_function alpha-actinin binding;GO:0055085,biological_process transmembrane transport;GO:0060402,biological_process calcium ion transport into cytosol;GO:0061337,biological_process cardiac conduction;GO:0061577,biological_process calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086002,biological_process cardiac muscle cell action potential involved in contraction;GO:0086007,molecular_function voltage-gated calcium channel activity involved in cardiac muscle cell action potential;GO:0086012,biological_process membrane depolarization during cardiac muscle cell action potential;GO:0086045,biological_process membrane depolarization during AV node cell action potential;GO:0086056,molecular_function voltage-gated calcium channel activity involved in AV node cell action potential;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential;GO:0098912,biological_process membrane depolarization during atrial cardiac muscle cell action potential;GO:1990454,cellular_component L-type voltage-gated calcium channel complex	CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C; K04850	calcium voltage-gated channel subunit alpha1 C [Source:HGNC Symbol%3BAcc:HGNC:1390]
ENSG00000143369	13.74	12.32	16.13	8.86	6.49	7.58	0.895189541634542	4.22141758277953	1.51022527199158e-12	5.06660170303552e-10	1:150508061-150513789:+	ECM1	29;GO:0001503,biological_process ossification;GO:0001525,biological_process angiogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001960,biological_process negative regulation of cytokine-mediated signaling pathway;GO:0002020,molecular_function protease binding;GO:0002576,biological_process platelet degranulation;GO:0002828,biological_process regulation of type 2 immune response;GO:0004871,molecular_function signal transducer activity;GO:0005134,molecular_function interleukin-2 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0010466,biological_process negative regulation of peptidase activity;GO:0019899,molecular_function enzyme binding;GO:0030500,biological_process regulation of bone mineralization;GO:0030502,biological_process negative regulation of bone mineralization;GO:0031012,cellular_component extracellular matrix;GO:0031089,cellular_component platelet dense granule lumen;GO:0031214,biological_process biomineral tissue development;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043236,molecular_function laminin binding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0070062,cellular_component extracellular exosome;GO:2000404,biological_process regulation of T cell migration	NA	extracellular matrix protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3153]
ENSG00000162591	12.82	11.99	13.29	9.32	8.16	9.29	0.522154460605724	5.77379842378276	1.74477789307272e-12	5.69945473334518e-10	1:3489919-3611495:-	MEGF6	5;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0008150,biological_process biological_process	NA	multiple EGF like domains 6 [Source:HGNC Symbol%3BAcc:HGNC:3232]
ENSG00000119906	21.63	21.30	22.22	29.53	28.87	32.04	-0.46089347711425	6.65413481190002	3.83895460239963e-12	1.22187034563043e-09	10:100912568-100965136:+	SLF2	14;GO:0000785,cellular_component chromatin;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0034184,biological_process positive regulation of maintenance of mitotic sister chromatid cohesion;GO:0035861,cellular_component site of double-strand break;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:1990166,biological_process protein localization to site of double-strand break;GO:2000781,biological_process positive regulation of double-strand break repair	NA	SMC5-SMC6 complex localization factor 2 [Source:HGNC Symbol%3BAcc:HGNC:17814]
ENSG00000155229	45.94	46.92	47.18	63.64	61.05	63.00	-0.410817368490482	7.48084476412667	6.28476909410922e-12	1.95032096912944e-09	10:97458323-97498794:-	MMS19	27;GO:0000160,biological_process phosphorelay signal transduction system;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005675,cellular_component holo TFIIH complex;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006259,biological_process DNA metabolic process;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007059,biological_process chromosome segregation;GO:0009725,biological_process response to hormone;GO:0016020,cellular_component membrane;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0019899,molecular_function enzyme binding;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030331,molecular_function estrogen receptor binding;GO:0030674,molecular_function protein binding, bridging;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0071817,cellular_component MMXD complex;GO:0097361,cellular_component CIA complex	NA	MMS19 homolog%2C cytosolic iron-sulfur assembly component [Source:HGNC Symbol%3BAcc:HGNC:13824]
ENSG00000244242	18.63	19.45	22.10	9.41	12.77	10.60	0.890091443528259	3.63398491210188	6.52549627105996e-12	1.97563378567481e-09	11:1732409-1750591:-	IFITM10	4;GO:0005886,cellular_component plasma membrane;GO:0009607,biological_process response to biotic stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	interferon induced transmembrane protein 10 [Source:HGNC Symbol%3BAcc:HGNC:40022]
ENSG00000124564	23.64	25.33	23.25	34.93	40.61	33.46	-0.584114792270744	5.50308419103696	6.98135483423934e-12	2.06332279898602e-09	6:25833065-25882286:-	SLC17A3	35;GO:0005436,molecular_function sodium:phosphate symporter activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006817,biological_process phosphate ion transport;GO:0006855,biological_process drug transmembrane transport;GO:0008308,molecular_function voltage-gated anion channel activity;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0015143,molecular_function urate transmembrane transporter activity;GO:0015238,molecular_function drug transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015562,molecular_function efflux transmembrane transporter activity;GO:0015711,biological_process organic anion transport;GO:0015747,biological_process urate transport;GO:0015760,biological_process glucose-6-phosphate transport;GO:0015893,biological_process drug transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019534,molecular_function toxin transporter activity;GO:0031526,cellular_component brush border membrane;GO:0034220,biological_process ion transmembrane transport;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0046415,biological_process urate metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055085,biological_process transmembrane transport;GO:1901998,biological_process toxin transport;GO:1903825,biological_process organic acid transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport	NA	solute carrier family 17 member 3 [Source:HGNC Symbol%3BAcc:HGNC:10931]
ENSG00000107566	68.39	72.68	68.53	97.75	94.08	94.57	-0.440475318411201	6.43543717822189	7.79510072737082e-12	2.25024617043847e-09	10:100150093-100188334:-	ERLIN1	17;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008289,molecular_function lipid binding;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032933,biological_process SREBP signaling pathway;GO:0043234,cellular_component protein complex;GO:0045541,biological_process negative regulation of cholesterol biosynthetic process;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0055085,biological_process transmembrane transport	NA	ER lipid raft associated 1 [Source:HGNC Symbol%3BAcc:HGNC:16947]
ENSG00000107554	6.97	6.36	6.95	9.85	9.12	9.53	-0.47569302218301	5.62004140848768	9.3173546616932e-12	2.62855280489995e-09	10:99875576-100009919:-	DNMBP	13;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005856,cellular_component cytoskeleton;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0030054,cellular_component cell junction;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse	NA	dynamin binding protein [Source:HGNC Symbol%3BAcc:HGNC:30373]
ENSG00000142156	87.76	85.04	86.88	67.04	66.73	64.87	0.398641767690275	7.8834444055035	1.12810167982748e-11	3.11180581148856e-09	21:45981736-46005050:+	COL6A1	20;GO:0001649,biological_process osteoblast differentiation;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005589,cellular_component collagen type VI trimer;GO:0005615,cellular_component extracellular space;GO:0005765,cellular_component lysosomal membrane;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035987,biological_process endodermal cell differentiation;GO:0042383,cellular_component sarcolemma;GO:0043234,cellular_component protein complex;GO:0048407,molecular_function platelet-derived growth factor binding;GO:0070062,cellular_component extracellular exosome;GO:0070208,biological_process protein heterotrimerization;GO:0071230,biological_process cellular response to amino acid stimulus	COL6A; collagen, type VI, alpha; K06238	collagen type VI alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2211]
ENSG00000122862	45.00	46.17	46.74	31.28	30.40	29.52	0.607883241946786	4.18462993540995	1.82385400875655e-11	4.92163039362937e-09	10:69088105-69104811:+	SRGN	21;GO:0000139,cellular_component Golgi membrane;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0006915,biological_process apoptotic process;GO:0008626,biological_process granzyme-mediated apoptotic signaling pathway;GO:0016485,biological_process protein processing;GO:0030502,biological_process negative regulation of bone mineralization;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031214,biological_process biomineral tissue development;GO:0033364,biological_process mast cell secretory granule organization;GO:0033368,biological_process protease localization to mast cell secretory granule;GO:0033371,biological_process T cell secretory granule organization;GO:0033373,biological_process maintenance of protease location in mast cell secretory granule;GO:0033382,biological_process maintenance of granzyme B location in T cell secretory granule;GO:0042588,cellular_component zymogen granule;GO:0042629,cellular_component mast cell granule;GO:0050710,biological_process negative regulation of cytokine secretion	NA	serglycin [Source:HGNC Symbol%3BAcc:HGNC:9361]
ENSG00000143344	4.29	4.12	4.44	2.43	2.43	2.31	0.857965688749194	3.04204216497941	1.90379569338486e-11	5.02804594510346e-09	1:183636084-183928531:+	RGL1	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008321,molecular_function Ral guanyl-nucleotide exchange factor activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0043547,biological_process positive regulation of GTPase activity	NA	ral guanine nucleotide dissociation stimulator like 1 [Source:HGNC Symbol%3BAcc:HGNC:30281]
ENSG00000142173	158.49	142.36	159.12	116.56	110.87	116.26	0.432543443908411	8.84195365889451	1.96409658358184e-11	5.07923560250029e-09	21:46098096-46132849:+	COL6A2	17;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0042383,cellular_component sarcolemma;GO:0043234,cellular_component protein complex;GO:0070062,cellular_component extracellular exosome;GO:0070208,biological_process protein heterotrimerization;GO:1903561,cellular_component extracellular vesicle	COL6A; collagen, type VI, alpha; K06238	collagen type VI alpha 2 chain [Source:HGNC Symbol%3BAcc:HGNC:2212]
ENSG00000172995	3.61	3.20	4.12	1.69	1.88	1.93	1.00930489230366	2.89101001107822	2.27391222923532e-11	5.76042295948939e-09	3:35638944-35794496:+	ARPP21	7;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005516,molecular_function calmodulin binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0034605,biological_process cellular response to heat	NA	cAMP regulated phosphoprotein 21 [Source:HGNC Symbol%3BAcc:HGNC:16968]
ENSG00000127329	2.75	2.85	2.76	1.76	1.93	1.57	0.677240905541954	3.94460704311864	5.9466921278366e-11	1.47632578765671e-08	12:70515865-70637440:-	PTPRB	19;GO:0001525,biological_process angiogenesis;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035579,cellular_component specific granule membrane;GO:0043235,cellular_component receptor complex;GO:0043312,biological_process neutrophil degranulation;GO:0070821,cellular_component tertiary granule membrane	PTPRB, PTPB; receptor-type tyrosine-protein phosphatase beta [EC:3.1.3.48]; K05694	protein tyrosine phosphatase%2C receptor type B [Source:HGNC Symbol%3BAcc:HGNC:9665]
ENSG00000100321	6.95	5.49	6.81	12.25	12.78	10.82	-0.868897551487556	3.27399893763083	6.17913230147851e-11	1.50395233839711e-08	22:39349924-39385588:+	SYNGR1	17;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006605,biological_process protein targeting;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031594,cellular_component neuromuscular junction;GO:0035577,cellular_component azurophil granule membrane;GO:0042470,cellular_component melanosome;GO:0043195,cellular_component terminal bouton;GO:0043312,biological_process neutrophil degranulation;GO:0045202,cellular_component synapse;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	synaptogyrin 1 [Source:HGNC Symbol%3BAcc:HGNC:11498]
ENSG00000111186	12.98	14.91	13.39	7.58	8.94	7.64	0.778654312161257	3.55989294066954	7.00859330978706e-11	1.67303209143051e-08	12:1529890-1647243:+	WNT5B	23;GO:0002062,biological_process chondrocyte differentiation;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0009986,cellular_component cell surface;GO:0016055,biological_process Wnt signaling pathway;GO:0030182,biological_process neuron differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030666,cellular_component endocytic vesicle membrane;GO:0042060,biological_process wound healing;GO:0045165,biological_process cell fate commitment;GO:0045444,biological_process fat cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0070307,biological_process lens fiber cell development;GO:0071300,biological_process cellular response to retinoic acid;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	WNT5; wingless-type MMTV integration site family, member 5; K00444	Wnt family member 5B [Source:HGNC Symbol%3BAcc:HGNC:16265]
ENSG00000087086	15378.00	15743.74	16062.15	12057.10	12702.96	12053.73	0.369823037274189	12.8452519910452	1.31731912132869e-10	3.08526080246283e-08	19:48965300-48966878:+	FTL	17;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0006826,biological_process iron ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006880,biological_process intracellular sequestering of iron ion;GO:0008043,cellular_component intracellular ferritin complex;GO:0008199,molecular_function ferric iron binding;GO:0016020,cellular_component membrane;GO:0035578,cellular_component azurophil granule lumen;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation;GO:0044754,cellular_component autolysosome;GO:0046872,molecular_function metal ion binding;GO:0055072,biological_process iron ion homeostasis;GO:0070062,cellular_component extracellular exosome	NA	ferritin light chain [Source:HGNC Symbol%3BAcc:HGNC:3999]
ENSG00000107815	11.81	12.18	13.62	18.25	17.97	17.82	-0.509601810369794	4.98997276376258	1.35099197128515e-10	3.10553024806713e-08	10:100987366-100994401:+	TWNK	19;GO:0000166,molecular_function nucleotide binding;GO:0002020,molecular_function protease binding;GO:0003678,molecular_function DNA helicase activity;GO:0003697,molecular_function single-stranded DNA binding;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006260,biological_process DNA replication;GO:0006264,biological_process mitochondrial DNA replication;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0007005,biological_process mitochondrion organization;GO:0016787,molecular_function hydrolase activity;GO:0034214,biological_process protein hexamerization;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043139,molecular_function 5'-3' DNA helicase activity;GO:0051260,biological_process protein homooligomerization;GO:0071333,biological_process cellular response to glucose stimulus	NA	twinkle mtDNA helicase [Source:HGNC Symbol%3BAcc:HGNC:1160]
ENSG00000198682	75.68	80.64	78.56	51.08	62.20	56.38	0.480557324804438	6.9696593409447	1.75802053525615e-10	3.96769252802446e-08	10:87659612-87747705:+	PAPSS2	16;GO:0000103,biological_process sulfate assimilation;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0003824,molecular_function catalytic activity;GO:0004020,molecular_function adenylylsulfate kinase activity;GO:0004781,molecular_function sulfate adenylyltransferase (ATP) activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0007596,biological_process blood coagulation;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0050428,biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0060348,biological_process bone development	PAPSS; 3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.7.4 2.7.1.25]; K13811	3'-phosphoadenosine 5'-phosphosulfate synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:8604]
ENSG00000185985	2.70	2.38	3.08	1.45	0.81	1.22	1.24509245664588	2.33523565197204	2.6530133414941e-10	5.88068832285112e-08	X:145817831-145825842:+	SLITRK2	5;GO:0005886,cellular_component plasma membrane;GO:0007409,biological_process axonogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051965,biological_process positive regulation of synapse assembly	NA	SLIT and NTRK like family member 2 [Source:HGNC Symbol%3BAcc:HGNC:13449]
ENSG00000103485	72.69	70.15	61.79	45.80	51.92	47.98	0.501053272230377	5.70326051369096	2.9068091908949e-10	6.33021447132954e-08	16:29679007-29698699:+	QPRT	14;GO:0003824,molecular_function catalytic activity;GO:0004514,molecular_function nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009435,biological_process NAD biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016763,molecular_function transferase activity, transferring pentosyl groups;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0019674,biological_process NAD metabolic process;GO:0034213,biological_process quinolinate catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome	nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]; K00767	quinolinate phosphoribosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:9755]
ENSG00000115339	6.17	5.42	6.14	3.12	3.69	3.57	0.79013579261197	3.24189816646021	4.43477190386861e-10	9.49117649012433e-08	2:165747590-165794682:-	GALNT3	20;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005509,molecular_function calcium ion binding;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018242,biological_process protein O-linked glycosylation via serine;GO:0018243,biological_process protein O-linked glycosylation via threonine;GO:0030145,molecular_function manganese ion binding;GO:0030246,molecular_function carbohydrate binding;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:4125]
ENSG00000185885	16.57	17.33	16.49	6.19	9.10	8.44	1.09168509128622	2.24307623776528	4.85565154617061e-10	1.02157970580705e-07	11:313505-315272:+	IFITM1	22;GO:0001503,biological_process ossification;GO:0002376,biological_process immune system process;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009607,biological_process response to biotic stimulus;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030336,biological_process negative regulation of cell migration;GO:0034341,biological_process response to interferon-gamma;GO:0035455,biological_process response to interferon-alpha;GO:0035456,biological_process response to interferon-beta;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0050776,biological_process regulation of immune response;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway	NA	interferon induced transmembrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:5412]
ENSG00000113140	731.89	746.50	705.75	505.06	594.35	498.93	0.462127689387329	9.16907502389332	6.11643647311976e-10	1.26538876568059e-07	5:151661095-151687165:-	SPARC	47;GO:0001503,biological_process ossification;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0002576,biological_process platelet degranulation;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0007507,biological_process heart development;GO:0009629,biological_process response to gravity;GO:0009986,cellular_component cell surface;GO:0010288,biological_process response to lead ion;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0016363,cellular_component nuclear matrix;GO:0016525,biological_process negative regulation of angiogenesis;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030198,biological_process extracellular matrix organization;GO:0030324,biological_process lung development;GO:0031091,cellular_component platelet alpha granule;GO:0031092,cellular_component platelet alpha granule membrane;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031982,cellular_component vesicle;GO:0032496,biological_process response to lipopolysaccharide;GO:0033591,biological_process response to L-ascorbic acid;GO:0034097,biological_process response to cytokine;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0043434,biological_process response to peptide hormone;GO:0043473,biological_process pigmentation;GO:0045471,biological_process response to ethanol;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding;GO:0048839,biological_process inner ear development;GO:0050840,molecular_function extracellular matrix binding;GO:0051384,biological_process response to glucocorticoid;GO:0051591,biological_process response to cAMP;GO:0051592,biological_process response to calcium ion;GO:0060348,biological_process bone development;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071682,cellular_component endocytic vesicle lumen	NA	secreted protein acidic and cysteine rich [Source:HGNC Symbol%3BAcc:HGNC:11219]
ENSG00000147676	50.03	57.01	51.02	76.15	71.82	74.18	-0.485890662101858	5.07290502620274	6.55775846323948e-10	1.33445009515068e-07	8:119165033-119245673:+	MAL2	15;GO:0001766,biological_process membrane raft polarization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0008104,biological_process protein localization;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019911,molecular_function structural constituent of myelin sheath;GO:0042552,biological_process myelination;GO:0045056,biological_process transcytosis;GO:0045121,cellular_component membrane raft;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	NA
ENSG00000152661	43.32	47.03	46.11	33.97	30.05	35.04	0.471010701672337	5.49387937691292	6.81687954395219e-10	1.36480525450127e-07	6:121435691-121449727:+	GJA1	86;GO:0000139,cellular_component Golgi membrane;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0002544,biological_process chronic inflammatory response;GO:0002931,biological_process response to ischemia;GO:0003104,biological_process positive regulation of glomerular filtration;GO:0003158,biological_process endothelium development;GO:0004871,molecular_function signal transducer activity;GO:0005243,molecular_function gap junction channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005916,cellular_component fascia adherens;GO:0005921,cellular_component gap junction;GO:0005922,cellular_component connexon complex;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0006936,biological_process muscle contraction;GO:0007154,biological_process cell communication;GO:0007165,biological_process signal transduction;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007267,biological_process cell-cell signaling;GO:0007507,biological_process heart development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009268,biological_process response to pH;GO:0009749,biological_process response to glucose;GO:0010232,biological_process vascular transport;GO:0010644,biological_process cell communication by electrical coupling;GO:0010652,biological_process positive regulation of cell communication by chemical coupling;GO:0014704,cellular_component intercalated disc;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016264,biological_process gap junction assembly;GO:0017124,molecular_function SH3 domain binding;GO:0019904,molecular_function protein domain specific binding;GO:0022857,molecular_function transmembrane transporter activity;GO:0022898,biological_process regulation of transmembrane transporter activity;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030308,biological_process negative regulation of cell growth;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032496,biological_process response to lipopolysaccharide;GO:0032526,biological_process response to retinoic acid;GO:0034220,biological_process ion transmembrane transport;GO:0034405,biological_process response to fluid shear stress;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0045121,cellular_component membrane raft;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0046697,biological_process decidualization;GO:0048812,biological_process neuron projection morphogenesis;GO:0051259,biological_process protein oligomerization;GO:0051924,biological_process regulation of calcium ion transport;GO:0055085,biological_process transmembrane transport;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:0061045,biological_process negative regulation of wound healing;GO:0070062,cellular_component extracellular exosome;GO:0071253,molecular_function connexin binding;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071374,biological_process cellular response to parathyroid hormone stimulus;GO:0086014,biological_process atrial cardiac muscle cell action potential;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0086075,molecular_function gap junction channel activity involved in cardiac conduction electrical coupling;GO:0097718,molecular_function disordered domain specific binding;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1903763,molecular_function gap junction channel activity involved in cell communication by electrical coupling;GO:1905867,biological_process epididymis development;GO:2000279,biological_process negative regulation of DNA biosynthetic process;GO:2000810,biological_process regulation of bicellular tight junction assembly;GO:2000987,biological_process positive regulation of behavioral fear response	GJA1, CX43; gap junction alpha-1 protein; K07372	gap junction protein alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:4274]
ENSG00000055163	3.36	3.03	3.82	5.54	5.25	5.17	-0.62369986615466	4.13679909156744	6.97766530092064e-10	1.37482157746552e-07	5:157266078-157395595:+	CYFIP2	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030054,cellular_component cell junction;GO:0031175,biological_process neuron projection development;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0045862,biological_process positive regulation of proteolysis;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051388,biological_process positive regulation of neurotrophin TRK receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:0097484,biological_process dendrite extension	NA	cytoplasmic FMR1 interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:13760]
ENSG00000105419	7.90	7.90	7.50	4.95	4.97	4.84	0.668222881582225	3.53696495167261	1.0147005652858e-09	1.96804345576447e-07	19:47403123-47419523:-	MEIS3	10;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	NA	Meis homeobox 3 [Source:HGNC Symbol%3BAcc:HGNC:29537]
ENSG00000155629	0.96	1.59	1.11	2.46	2.64	2.91	-1.15157776047738	2.37897139850488	1.04638286562132e-09	1.99826930937807e-07	10:96593311-96720514:-	PIK3AP1	17;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0034134,biological_process toll-like receptor 2 signaling pathway;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0034154,biological_process toll-like receptor 7 signaling pathway;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0036312,molecular_function phosphatidylinositol 3-kinase regulatory subunit binding;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050727,biological_process regulation of inflammatory response	PIK3AP1, BCAP; phosphoinositide 3-kinase adapter protein 1; K12230	phosphoinositide-3-kinase adaptor protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30034]
ENSG00000184985	9.17	7.83	8.93	6.30	5.70	6.04	0.540757565147469	4.7011034601765	1.53279525952231e-09	2.88281629643188e-07	4:7192537-7742836:+	SORCS2	4;GO:0007218,biological_process neuropeptide signaling pathway;GO:0008188,molecular_function neuropeptide receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	sortilin related VPS10 domain containing receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:16698]
ENSG00000025039	15.71	15.77	14.29	25.46	21.93	21.62	-0.581943544131919	4.53478840709541	1.72902951942997e-09	3.20334976487825e-07	6:89364635-89412270:-	RRAGD	24;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0007050,biological_process cell cycle arrest;GO:0010506,biological_process regulation of autophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0019003,molecular_function GDP binding;GO:0032008,biological_process positive regulation of TOR signaling;GO:0034448,cellular_component EGO complex;GO:0034613,biological_process cellular protein localization;GO:0046982,molecular_function protein heterodimerization activity;GO:0051020,molecular_function GTPase binding;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071233,biological_process cellular response to leucine;GO:1904263,biological_process positive regulation of TORC1 signaling;GO:1990131,cellular_component Gtr1-Gtr2 GTPase complex;GO:1990253,biological_process cellular response to leucine starvation	RRAGC_D; Ras-related GTP-binding protein C/D; K16186	Ras related GTP binding D [Source:HGNC Symbol%3BAcc:HGNC:19903]
ENSG00000119655	280.20	292.66	275.76	210.46	232.40	208.66	0.392752240989042	8.02688768179414	2.22702003617676e-09	4.06529407486207e-07	14:74476191-74494177:-	NPC2	25;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0006629,biological_process lipid metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0009615,biological_process response to virus;GO:0015485,molecular_function cholesterol binding;GO:0015914,biological_process phospholipid transport;GO:0019747,biological_process regulation of isoprenoid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0030301,biological_process cholesterol transport;GO:0032366,biological_process intracellular sterol transport;GO:0032367,biological_process intracellular cholesterol transport;GO:0033344,biological_process cholesterol efflux;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035578,cellular_component azurophil granule lumen;GO:0042632,biological_process cholesterol homeostasis;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046836,biological_process glycolipid transport;GO:0070062,cellular_component extracellular exosome	NPC2; Niemann-Pick C2 protein; K13443	NPC intracellular cholesterol transporter 2 [Source:HGNC Symbol%3BAcc:HGNC:14537]
ENSG00000171307	47.76	47.74	43.39	60.07	66.78	61.21	-0.426520420970352	6.02306207718669	2.29727884311878e-09	4.13277134487441e-07	10:97446130-97457370:+	ZDHHC16	11;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 16 [Source:HGNC Symbol%3BAcc:HGNC:20714]
ENSG00000137491	9.22	9.16	10.70	6.83	5.16	6.22	0.688399951074901	4.09906892014471	2.60669978092277e-09	4.62242348294205e-07	11:75100562-75206549:+	SLCO2B1	15;GO:0001889,biological_process liver development;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0015125,molecular_function bile acid transmembrane transporter activity;GO:0015347,molecular_function sodium-independent organic anion transmembrane transporter activity;GO:0015721,biological_process bile acid and bile salt transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0043252,biological_process sodium-independent organic anion transport;GO:0071718,biological_process sodium-independent icosanoid transport	NA	solute carrier organic anion transporter family member 2B1 [Source:HGNC Symbol%3BAcc:HGNC:10962]
ENSG00000135821	132.54	118.45	129.90	101.03	94.07	95.71	0.40253090256644	6.97187263689519	2.91163976630526e-09	5.09044850973904e-07	1:182381703-182392206:-	GLUL	42;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001504,biological_process neurotransmitter uptake;GO:0003824,molecular_function catalytic activity;GO:0004351,molecular_function glutamate decarboxylase activity;GO:0004356,molecular_function glutamate-ammonia ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006536,biological_process glutamate metabolic process;GO:0006538,biological_process glutamate catabolic process;GO:0006542,biological_process glutamine biosynthetic process;GO:0006807,biological_process nitrogen compound metabolic process;GO:0008283,biological_process cell proliferation;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009267,biological_process cellular response to starvation;GO:0009749,biological_process response to glucose;GO:0016595,molecular_function glutamate binding;GO:0016829,molecular_function lyase activity;GO:0016874,molecular_function ligase activity;GO:0019676,biological_process ammonia assimilation cycle;GO:0030145,molecular_function manganese ion binding;GO:0032024,biological_process positive regulation of insulin secretion;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043204,cellular_component perikaryon;GO:0043209,cellular_component myelin sheath;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043679,cellular_component axon terminus;GO:0044297,cellular_component cell body;GO:0045503,molecular_function dynein light chain binding;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051260,biological_process protein homooligomerization;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0070062,cellular_component extracellular exosome;GO:0097386,cellular_component glial cell projection	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]; K01915	glutamate-ammonia ligase [Source:HGNC Symbol%3BAcc:HGNC:4341]
ENSG00000112655	8.67	7.87	8.06	11.70	11.54	10.74	-0.449476443990992	5.16247414120094	3.02644953094787e-09	5.21768305939666e-07	6:43076267-43161719:+	PTK7	33;GO:0001736,biological_process establishment of planar polarity;GO:0001843,biological_process neural tube closure;GO:0003281,biological_process ventricular septum development;GO:0003401,biological_process axis elongation;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007507,biological_process heart development;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016477,biological_process cell migration;GO:0030054,cellular_component cell junction;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0042060,biological_process wound healing;GO:0045198,biological_process establishment of epithelial cell apical/basal polarity;GO:0060026,biological_process convergent extension;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060484,biological_process lung-associated mesenchyme development;GO:0060976,biological_process coronary vasculature development;GO:0071300,biological_process cellular response to retinoic acid;GO:0090103,biological_process cochlea morphogenesis;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:1904929,molecular_function coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	NA	protein tyrosine kinase 7 (inactive) [Source:HGNC Symbol%3BAcc:HGNC:9618]
ENSG00000075891	12.71	13.00	14.47	18.33	22.28	19.79	-0.574194166051788	4.55632631299439	5.1667730903103e-09	8.78563758493449e-07	10:100735602-100829941:+	PAX2	85;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001655,biological_process urogenital system development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001709,biological_process cell fate determination;GO:0001823,biological_process mesonephros development;GO:0001843,biological_process neural tube closure;GO:0002072,biological_process optic cup morphogenesis involved in camera-type eye development;GO:0003337,biological_process mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0003406,biological_process retinal pigment epithelium development;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005764,cellular_component lysosome;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007409,biological_process axonogenesis;GO:0007501,biological_process mesodermal cell fate specification;GO:0007568,biological_process aging;GO:0007601,biological_process visual perception;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010001,biological_process glial cell differentiation;GO:0016175,molecular_function superoxide-generating NADPH oxidase activity;GO:0021554,biological_process optic nerve development;GO:0021631,biological_process optic nerve morphogenesis;GO:0021633,biological_process optic nerve structural organization;GO:0021650,biological_process vestibulocochlear nerve formation;GO:0030154,biological_process cell differentiation;GO:0031667,biological_process response to nutrient levels;GO:0032993,cellular_component protein-DNA complex;GO:0034451,cellular_component centriolar satellite;GO:0035566,biological_process regulation of metanephros size;GO:0035799,biological_process ureter maturation;GO:0039003,biological_process pronephric field specification;GO:0042472,biological_process inner ear morphogenesis;GO:0043010,biological_process camera-type eye development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043234,cellular_component protein complex;GO:0043491,biological_process protein kinase B signaling;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045918,biological_process negative regulation of cytolysis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048513,biological_process animal organ development;GO:0048793,biological_process pronephros development;GO:0048854,biological_process brain morphogenesis;GO:0048863,biological_process stem cell differentiation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0055114,biological_process oxidation-reduction process;GO:0060231,biological_process mesenchymal to epithelial transition;GO:0061360,biological_process optic chiasma development;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071300,biological_process cellular response to retinoic acid;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0072075,biological_process metanephric mesenchyme development;GO:0072108,biological_process positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072162,biological_process metanephric mesenchymal cell differentiation;GO:0072179,biological_process nephric duct formation;GO:0072189,biological_process ureter development;GO:0072205,biological_process metanephric collecting duct development;GO:0072207,biological_process metanephric epithelium development;GO:0072221,biological_process metanephric distal convoluted tubule development;GO:0072289,biological_process metanephric nephron tubule formation;GO:0072300,biological_process positive regulation of metanephric glomerulus development;GO:0072305,biological_process negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis;GO:0072307,biological_process regulation of metanephric nephron tubule epithelial cell differentiation;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090102,biological_process cochlea development;GO:0090103,biological_process cochlea morphogenesis;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:1900212,biological_process negative regulation of mesenchymal cell apoptotic process involved in metanephros development;GO:1900215,biological_process negative regulation of apoptotic process involved in metanephric collecting duct development;GO:1900218,biological_process negative regulation of apoptotic process involved in metanephric nephron tubule development;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2000594,biological_process positive regulation of metanephric DCT cell differentiation;GO:2000597,biological_process positive regulation of optic nerve formation	NA	paired box 2 [Source:HGNC Symbol%3BAcc:HGNC:8616]
ENSG00000101670	15.65	17.96	15.17	11.35	11.18	11.60	0.519611026210592	4.6952092068662	5.61954983658076e-09	9.42641515155094e-07	18:49560698-49599182:+	LIPG	24;GO:0004465,molecular_function lipoprotein lipase activity;GO:0004620,molecular_function phospholipase activity;GO:0004806,molecular_function triglyceride lipase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0007584,biological_process response to nutrient;GO:0008201,molecular_function heparin binding;GO:0008283,biological_process cell proliferation;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0009395,biological_process phospholipid catabolic process;GO:0009986,cellular_component cell surface;GO:0010983,biological_process positive regulation of high-density lipoprotein particle clearance;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0032376,biological_process positive regulation of cholesterol transport;GO:0034375,biological_process high-density lipoprotein particle remodeling;GO:0042632,biological_process cholesterol homeostasis;GO:0043691,biological_process reverse cholesterol transport;GO:0050746,biological_process regulation of lipoprotein metabolic process;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0055091,biological_process phospholipid homeostasis	lip, TGL2; triacylglycerol lipase [EC:3.1.1.3]; K01046	lipase G%2C endothelial type [Source:HGNC Symbol%3BAcc:HGNC:6623]
ENSG00000162645	11.95	11.32	11.87	7.39	8.60	8.25	0.550087595621219	4.14282941316885	8.04539447513434e-09	1.3315664215979e-06	1:89106131-89150456:-	GBP2	16;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006955,biological_process immune response;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway	NA	guanylate binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4183]
ENSG00000130702	15.63	12.80	15.77	10.68	10.28	11.31	0.466684744170041	7.19032176945877	8.92677436245449e-09	1.4580006600151e-06	20:62307954-62367312:-	LAMA5	45;GO:0001525,biological_process angiogenesis;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001738,biological_process morphogenesis of a polarized epithelium;GO:0001755,biological_process neural crest cell migration;GO:0001942,biological_process hair follicle development;GO:0005102,molecular_function receptor binding;GO:0005178,molecular_function integrin binding;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005605,cellular_component basal lamina;GO:0005610,cellular_component laminin-5 complex;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0007010,biological_process cytoskeleton organization;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007517,biological_process muscle organ development;GO:0008037,biological_process cell recognition;GO:0008283,biological_process cell proliferation;GO:0009790,biological_process embryo development;GO:0009887,biological_process organ morphogenesis;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0016477,biological_process cell migration;GO:0030154,biological_process cell differentiation;GO:0030155,biological_process regulation of cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030324,biological_process lung development;GO:0030334,biological_process regulation of cell migration;GO:0031012,cellular_component extracellular matrix;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042127,biological_process regulation of cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043083,cellular_component synaptic cleft;GO:0043259,cellular_component laminin-10 complex;GO:0043260,cellular_component laminin-11 complex;GO:0045446,biological_process endothelial cell differentiation;GO:0045995,biological_process regulation of embryonic development;GO:0048041,biological_process focal adhesion assembly;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0060271,biological_process cilium morphogenesis;GO:0060445,biological_process branching involved in salivary gland morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0090002,biological_process establishment of protein localization to plasma membrane	LAMA3_5; laminin, alpha 3/5; K06240	laminin subunit alpha 5 [Source:HGNC Symbol%3BAcc:HGNC:6485]
ENSG00000164638	43.49	40.99	44.48	29.43	34.49	33.39	0.419766891040872	5.90982351398815	9.84046668972173e-09	1.58635990934436e-06	7:5274368-5306870:+	SLC29A4	10;GO:0005337,molecular_function nucleoside transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008504,molecular_function monoamine transmembrane transporter activity;GO:0015844,biological_process monoamine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0055085,biological_process transmembrane transport;GO:1901642,biological_process nucleoside transmembrane transport	NA	solute carrier family 29 member 4 [Source:HGNC Symbol%3BAcc:HGNC:23097]
ENSG00000134072	112.96	107.13	106.04	144.51	133.57	147.21	-0.370999089552	7.31954681318143	1.0234804792009e-08	1.62877733183599e-06	3:9757341-9769992:-	CAMK1	38;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006913,biological_process nucleocytoplasmic transport;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008152,biological_process metabolic process;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030154,biological_process cell differentiation;GO:0032091,biological_process negative regulation of protein binding;GO:0032880,biological_process regulation of protein localization;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0043393,biological_process regulation of protein binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0051147,biological_process regulation of muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051835,biological_process positive regulation of synapse structural plasticity;GO:0060143,biological_process positive regulation of syncytium formation by plasma membrane fusion;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:1901985,biological_process positive regulation of protein acetylation	CAMK1; calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]; K08794	calcium/calmodulin dependent protein kinase I [Source:HGNC Symbol%3BAcc:HGNC:1459]
ENSG00000101210	90.66	83.66	89.55	122.68	108.00	118.66	-0.392020990554101	7.15277610127104	1.27505705029387e-08	2.00345356522758e-06	20:63488012-63499315:-	EEF1A2	19;GO:0000166,molecular_function nucleotide binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005853,cellular_component eukaryotic translation elongation factor 1 complex;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0010035,biological_process response to inorganic substance;GO:0019901,molecular_function protein kinase binding;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043209,cellular_component myelin sheath;GO:0051602,biological_process response to electrical stimulus;GO:0090218,biological_process positive regulation of lipid kinase activity;GO:0098574,cellular_component cytoplasmic side of lysosomal membrane;GO:1904714,biological_process regulation of chaperone-mediated autophagy	NA	eukaryotic translation elongation factor 1 alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:3192]
ENSG00000156804	40.52	48.28	44.51	32.76	33.11	32.42	0.446446095470892	5.3622489865547	1.50265969517862e-08	2.33156434953153e-06	8:123497888-123541206:-	FBXO32	13;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0014894,biological_process response to denervation involved in regulation of muscle adaptation;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030018,cellular_component Z disc;GO:0043687,biological_process post-translational protein modification;GO:0071549,biological_process cellular response to dexamethasone stimulus	FBXO25_32; F-box protein 25/32; K10305	F-box protein 32 [Source:HGNC Symbol%3BAcc:HGNC:16731]
ENSG00000109814	148.17	160.97	157.03	117.26	121.87	126.81	0.360434434035604	7.72227594338517	1.53363106092622e-08	2.35024226657742e-06	4:39498754-39528311:-	UGDH	16;GO:0001702,biological_process gastrulation with mouth forming second;GO:0003824,molecular_function catalytic activity;GO:0003979,molecular_function UDP-glucose 6-dehydrogenase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006011,biological_process UDP-glucose metabolic process;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006065,biological_process UDP-glucuronate biosynthetic process;GO:0008152,biological_process metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]; K00012	UDP-glucose 6-dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:12525]
ENSG00000119888	10.14	9.27	9.41	14.30	13.63	14.43	-0.540177974162313	4.00135500445496	1.65253066994276e-08	2.50156868365847e-06	2:47345157-47387601:+	EPCAM	25;GO:0001657,biological_process ureteric bud development;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0023019,biological_process signal transduction involved in regulation of gene expression;GO:0030054,cellular_component cell junction;GO:0032403,molecular_function protein complex binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048863,biological_process stem cell differentiation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:0098742,biological_process cell-cell adhesion via plasma-membrane adhesion molecules;GO:2000048,biological_process negative regulation of cell-cell adhesion mediated by cadherin;GO:2000147,biological_process positive regulation of cell motility;GO:2000648,biological_process positive regulation of stem cell proliferation	NA	epithelial cell adhesion molecule [Source:HGNC Symbol%3BAcc:HGNC:11529]
ENSG00000187134	66.12	88.08	63.48	34.91	52.84	35.74	0.828205289113731	5.95977037581077	1.7166842753087e-08	2.56737372402493e-06	10:4963252-4983283:+	AKR1C1	32;GO:0001523,biological_process retinoid metabolic process;GO:0004032,molecular_function alditol:NADP+ 1-oxidoreductase activity;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006805,biological_process xenobiotic metabolic process;GO:0007586,biological_process digestion;GO:0008206,biological_process bile acid metabolic process;GO:0015721,biological_process bile acid and bile salt transport;GO:0016491,molecular_function oxidoreductase activity;GO:0016655,molecular_function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636,molecular_function phenanthrene 9,10-monooxygenase activity;GO:0030299,biological_process intestinal cholesterol absorption;GO:0030855,biological_process epithelial cell differentiation;GO:0031406,molecular_function carboxylic acid binding;GO:0032052,molecular_function bile acid binding;GO:0042448,biological_process progesterone metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0042632,biological_process cholesterol homeostasis;GO:0044597,biological_process daunorubicin metabolic process;GO:0044598,biological_process doxorubicin metabolic process;GO:0046683,biological_process response to organophosphorus;GO:0047006,molecular_function 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity;GO:0047042,molecular_function androsterone dehydrogenase (B-specific) activity;GO:0047086,molecular_function ketosteroid monooxygenase activity;GO:0047115,molecular_function trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0047718,molecular_function indanol dehydrogenase activity;GO:0051260,biological_process protein homooligomerization;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0071395,biological_process cellular response to jasmonic acid stimulus	AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]; K00089	aldo-keto reductase family 1 member C1 [Source:HGNC Symbol%3BAcc:HGNC:384]
ENSG00000178573	34.03	30.88	32.50	24.68	24.75	24.76	0.408239796471145	5.155547866399	2.2330941027889e-08	3.29992822594269e-06	16:79585842-79600714:-	MAF	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001816,biological_process cytokine production;GO:0002088,biological_process lens development in camera-type eye;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0010628,biological_process positive regulation of gene expression;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048468,biological_process cell development;GO:0048839,biological_process inner ear development;GO:0070306,biological_process lens fiber cell differentiation	CMAF, MAF; transcription factor Maf; K09035	MAF bZIP transcription factor [Source:HGNC Symbol%3BAcc:HGNC:6776]
ENSG00000166710	4347.15	4461.33	4586.57	3570.57	3688.66	3561.01	0.319752528586865	10.4943445554737	2.46089982526504e-08	3.59378229776646e-06	15:44711476-44718877:+	B2M	58;GO:0000139,cellular_component Golgi membrane;GO:0001895,biological_process retina homeostasis;GO:0001916,biological_process positive regulation of T cell mediated cytotoxicity;GO:0002237,biological_process response to molecule of bacterial origin;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002481,biological_process antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent;GO:0002726,biological_process positive regulation of T cell cytokine production;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006826,biological_process iron ion transport;GO:0006955,biological_process immune response;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010977,biological_process negative regulation of neuron projection development;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0019885,biological_process antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031901,cellular_component early endosome membrane;GO:0031905,cellular_component early endosome lumen;GO:0032092,biological_process positive regulation of protein binding;GO:0033077,biological_process T cell differentiation in thymus;GO:0033216,biological_process ferric iron import;GO:0035580,cellular_component specific granule lumen;GO:0042026,biological_process protein refolding;GO:0042493,biological_process response to drug;GO:0042612,cellular_component MHC class I protein complex;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation;GO:0044267,biological_process cellular protein metabolic process;GO:0045087,biological_process innate immune response;GO:0045646,biological_process regulation of erythrocyte differentiation;GO:0046686,biological_process response to cadmium ion;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050776,biological_process regulation of immune response;GO:0055038,cellular_component recycling endosome membrane;GO:0055072,biological_process iron ion homeostasis;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071281,biological_process cellular response to iron ion;GO:0071283,biological_process cellular response to iron(III) ion;GO:1900121,biological_process negative regulation of receptor binding;GO:1900122,biological_process positive regulation of receptor binding;GO:1904434,biological_process positive regulation of ferrous iron binding;GO:1904437,biological_process positive regulation of transferrin receptor binding;GO:1904440,biological_process positive regulation of ferrous iron import across plasma membrane;GO:1904724,cellular_component tertiary granule lumen;GO:1990712,cellular_component HFE-transferrin receptor complex	B2M; beta-2-microglobulin; K08055	beta-2-microglobulin [Source:HGNC Symbol%3BAcc:HGNC:914]
ENSG00000110811	46.76	45.10	46.70	35.20	37.27	36.82	0.355026682037528	6.513874197323	2.69802903837182e-08	3.89425982015225e-06	12:6828409-6839851:+	P3H3	12;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0019511,biological_process peptidyl-proline hydroxylation;GO:0019797,molecular_function procollagen-proline 3-dioxygenase activity;GO:0031418,molecular_function L-ascorbic acid binding;GO:0032963,biological_process collagen metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	prolyl 3-hydroxylase 3 [Source:HGNC Symbol%3BAcc:HGNC:19318]
ENSG00000166033	162.24	149.98	161.87	128.06	118.93	127.11	0.354199913679609	7.67168212880702	2.96042210644188e-08	4.22387581692679e-06	10:122461524-122514908:+	HTRA1	24;GO:0001558,biological_process regulation of cell growth;GO:0001890,biological_process placenta development;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019838,molecular_function growth factor binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0031012,cellular_component extracellular matrix;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050687,biological_process negative regulation of defense response to virus;GO:0060718,biological_process chorionic trophoblast cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0097187,biological_process dentinogenesis	NA	HtrA serine peptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:9476]
ENSG00000135298	0.54	0.55	0.44	0.08	0.13	0.24	1.74555348765763	0.742958307213929	3.23041460118133e-08	4.55672005050726e-06	6:68635366-69389511:+	ADGRB3	21;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007520,biological_process myoblast fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016322,biological_process neuron remodeling;GO:0016525,biological_process negative regulation of angiogenesis;GO:0043083,cellular_component synaptic cleft;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0051965,biological_process positive regulation of synapse assembly;GO:0061743,biological_process motor learning;GO:0098794,cellular_component postsynapse;GO:0099558,biological_process maintenance of synapse structure	NA	adhesion G protein-coupled receptor B3 [Source:HGNC Symbol%3BAcc:HGNC:945]
ENSG00000055950	73.47	69.73	66.99	87.93	92.67	90.93	-0.357158840047886	6.28657132598748	3.73022489180111e-08	5.20261590808171e-06	10:100969457-100987515:-	MRPL43	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L43 [Source:HGNC Symbol%3BAcc:HGNC:14517]
ENSG00000169174	2.11	2.58	2.13	0.83	1.24	0.98	1.1552751319587	1.80913625546769	3.80094445797779e-08	5.24234706187537e-06	1:55039547-55064852:+	PCSK9	70;GO:0001822,biological_process kidney development;GO:0001889,biological_process liver development;GO:0001920,biological_process negative regulation of receptor recycling;GO:0002092,biological_process positive regulation of receptor internalization;GO:0003723,molecular_function RNA binding;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006915,biological_process apoptotic process;GO:0007041,biological_process lysosomal transport;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009267,biological_process cellular response to starvation;GO:0009986,cellular_component cell surface;GO:0010469,biological_process regulation of receptor activity;GO:0010989,biological_process negative regulation of low-density lipoprotein particle clearance;GO:0016485,biological_process protein processing;GO:0016540,biological_process protein autoprocessing;GO:0016787,molecular_function hydrolase activity;GO:0019871,molecular_function sodium channel inhibitor activity;GO:0022008,biological_process neurogenesis;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030182,biological_process neuron differentiation;GO:0030547,molecular_function receptor inhibitor activity;GO:0031232,cellular_component extrinsic component of external side of plasma membrane;GO:0032799,biological_process low-density lipoprotein receptor particle metabolic process;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0032803,biological_process regulation of low-density lipoprotein particle receptor catabolic process;GO:0032805,biological_process positive regulation of low-density lipoprotein particle receptor catabolic process;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034185,molecular_function apolipoprotein binding;GO:0034189,molecular_function very-low-density lipoprotein particle binding;GO:0034190,molecular_function apolipoprotein receptor binding;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0036020,cellular_component endolysosome membrane;GO:0042157,biological_process lipoprotein metabolic process;GO:0042632,biological_process cholesterol homeostasis;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043621,molecular_function protein self-association;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0070326,molecular_function very-low-density lipoprotein particle receptor binding;GO:1905596,biological_process negative regulation of low-density lipoprotein particle receptor binding;GO:1905598,biological_process negative regulation of low-density lipoprotein receptor activity;GO:1905601,biological_process negative regulation of receptor-mediated endocytosis involved in cholesterol transport;GO:1990666,cellular_component PCSK9-LDLR complex;GO:1990667,cellular_component PCSK9-AnxA2 complex;GO:2000650,biological_process negative regulation of sodium ion transmembrane transporter activity	PCSK9; proprotein convertase subtilisin/kexin type 9 [EC:3.4.21.-]; K13050	proprotein convertase subtilisin/kexin type 9 [Source:HGNC Symbol%3BAcc:HGNC:20001]
ENSG00000164418	1.56	1.18	1.16	0.53	0.56	0.54	1.28012682087925	1.5309813105379	5.52432493996144e-08	7.53554345931224e-06	6:101398787-102070083:+	GRIK2	56;GO:0001662,biological_process behavioral fear response;GO:0004872,molecular_function receptor activity;GO:0004970,molecular_function ionotropic glutamate receptor activity;GO:0005216,molecular_function ion channel activity;GO:0005234,molecular_function extracellular-glutamate-gated ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006886,biological_process intracellular protein transport;GO:0007215,biological_process glutamate receptor signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0008066,molecular_function glutamate receptor activity;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0014069,cellular_component postsynaptic density;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015277,molecular_function kainate selective glutamate receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019228,biological_process neuronal action potential;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032839,cellular_component dendrite cytoplasm;GO:0032983,cellular_component kainate selective glutamate receptor complex;GO:0034220,biological_process ion transmembrane transport;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0042734,cellular_component presynaptic membrane;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0043113,biological_process receptor clustering;GO:0043195,cellular_component terminal bouton;GO:0043204,cellular_component perikaryon;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046328,biological_process regulation of JNK cascade;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:0050804,biological_process modulation of synaptic transmission;GO:0050806,biological_process positive regulation of synaptic transmission;GO:0051402,biological_process neuron apoptotic process;GO:0051967,biological_process negative regulation of synaptic transmission, glutamatergic;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060080,biological_process inhibitory postsynaptic potential;GO:0071805,biological_process potassium ion transmembrane transport;GO:0098794,cellular_component postsynapse	GRIK2; glutamate receptor, ionotropic kainate 2; K05202	glutamate ionotropic receptor kainate type subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:4580]
ENSG00000006831	46.78	49.27	44.17	63.95	59.60	59.57	-0.375939607598215	5.96852354540584	5.67320657030529e-08	7.65451229969561e-06	12:1688573-1788678:+	ADIPOR2	24;GO:0004872,molecular_function receptor activity;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007507,biological_process heart development;GO:0007565,biological_process female pregnancy;GO:0007584,biological_process response to nutrient;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019395,biological_process fatty acid oxidation;GO:0030308,biological_process negative regulation of cell growth;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0033211,biological_process adiponectin-activated signaling pathway;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0046326,biological_process positive regulation of glucose import;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0055100,molecular_function adiponectin binding;GO:0061042,biological_process vascular wound healing;GO:0097003,molecular_function adipokinetic hormone receptor activity	ADIPOR; adiponectin receptor; K07297	adiponectin receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:24041]
ENSG00000155287	28.78	26.87	29.79	43.54	34.80	44.17	-0.50619074197751	5.25360567272104	6.49025405634352e-08	8.66274447326797e-06	10:99610521-99620609:-	SLC25A28	11;GO:0005381,molecular_function iron ion transmembrane transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034755,biological_process iron ion transmembrane transport;GO:0048250,biological_process mitochondrial iron ion transport;GO:0055072,biological_process iron ion homeostasis	NA	solute carrier family 25 member 28 [Source:HGNC Symbol%3BAcc:HGNC:23472]
ENSG00000122420	9.11	8.90	9.50	6.14	5.51	5.89	0.662493876981316	3.15475096718683	7.9104297212668e-08	1.04459749074558e-05	1:78303883-78539749:+	PTGFR	19;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004958,molecular_function prostaglandin F receptor activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007567,biological_process parturition;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032355,biological_process response to estradiol;GO:0032496,biological_process response to lipopolysaccharide;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0043066,biological_process negative regulation of apoptotic process;GO:0071799,biological_process cellular response to prostaglandin D stimulus	PTGFR; prostaglandin F receptor; K04262	prostaglandin F receptor [Source:HGNC Symbol%3BAcc:HGNC:9600]
ENSG00000144152	10.50	9.13	9.16	5.79	5.30	7.00	0.681495548176763	3.55484200705502	8.21221116460267e-08	1.0730334440654e-05	2:112138384-112188216:+	FBLN7	7;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0008201,molecular_function heparin binding;GO:0070062,cellular_component extracellular exosome	NA	fibulin 7 [Source:HGNC Symbol%3BAcc:HGNC:26740]
ENSG00000099954	0.08	0.12	0.19	0.46	0.46	0.46	-1.78148754919209	0.61494253175283	9.11326517032706e-08	1.17836417249239e-05	22:17359948-17558149:+	CECR2	17;GO:0000910,biological_process cytokinesis;GO:0001842,biological_process neural fold formation;GO:0001843,biological_process neural tube closure;GO:0005634,cellular_component nucleus;GO:0005719,cellular_component nuclear euchromatin;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0007010,biological_process cytoskeleton organization;GO:0007338,biological_process single fertilization;GO:0016192,biological_process vesicle-mediated transport;GO:0016569,biological_process covalent chromatin modification;GO:0021915,biological_process neural tube development;GO:0031010,cellular_component ISWI-type complex;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0090102,biological_process cochlea development;GO:0090537,cellular_component CERF complex;GO:0097194,biological_process execution phase of apoptosis	NA	CECR2%2C histone acetyl-lysine reader [Source:HGNC Symbol%3BAcc:HGNC:1840]
ENSG00000145860	58.14	56.52	57.22	75.96	68.50	76.73	-0.35187540107494	7.13374856189934	9.51923247308909e-08	1.21816734730366e-05	5:159157408-159210053:-	RNF145	8;GO:0000209,biological_process protein polyubiquitination;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 145 [Source:HGNC Symbol%3BAcc:HGNC:20853]
ENSG00000196072	53.47	51.47	53.92	82.77	66.70	72.70	-0.470574675625831	5.08668577430708	9.64818433561963e-08	1.22207053222496e-05	10:100273279-100286712:-	BLOC1S2	24;GO:0000930,cellular_component gamma-tubulin complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008089,biological_process anterograde axonal transport;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0032418,biological_process lysosome localization;GO:0032438,biological_process melanosome organization;GO:0043015,molecular_function gamma-tubulin binding;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0055114,biological_process oxidation-reduction process;GO:0060155,biological_process platelet dense granule organization;GO:0097345,biological_process mitochondrial outer membrane permeabilization;GO:0099078,cellular_component BORC complex;GO:1904115,cellular_component axon cytoplasm	NA	biogenesis of lysosomal organelles complex 1 subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:20984]
ENSG00000089685	87.82	88.16	86.27	113.06	113.94	107.82	-0.340882996923862	6.0094961201495	1.06800576182687e-07	1.33910661833909e-05	17:78214185-78225636:+	BIRC5	49;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000228,cellular_component nuclear chromosome;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007605,biological_process sensory perception of sound;GO:0008017,molecular_function microtubule binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008536,molecular_function Ran GTPase binding;GO:0009966,biological_process regulation of signal transduction;GO:0010466,biological_process negative regulation of peptidase activity;GO:0016567,biological_process protein ubiquitination;GO:0016925,biological_process protein sumoylation;GO:0019899,molecular_function enzyme binding;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030496,cellular_component midbody;GO:0031503,biological_process protein complex localization;GO:0032133,cellular_component chromosome passenger complex;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0051301,biological_process cell division;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0061469,biological_process regulation of type B pancreatic cell proliferation;GO:0090307,biological_process mitotic spindle assembly;GO:1990001,biological_process inhibition of cysteine-type endopeptidase activity involved in apoptotic process	BIRC5; baculoviral IAP repeat-containing protein 5; K08731	baculoviral IAP repeat containing 5 [Source:HGNC Symbol%3BAcc:HGNC:593]
ENSG00000166024	15.76	16.23	14.85	19.98	20.34	20.63	-0.37101985750534	5.42488946117731	1.1812321122445e-07	1.4662634209291e-05	10:98134623-98244897:+	R3HCC1L	2;GO:0005515,molecular_function protein binding;GO:0035145,cellular_component exon-exon junction complex	NA	R3H domain and coiled-coil containing 1 like [Source:HGNC Symbol%3BAcc:HGNC:23512]
ENSG00000102931	52.11	57.50	58.88	75.63	73.80	73.39	-0.393726926716895	5.2862141129548	1.23918842177785e-07	1.52297483955728e-05	16:57245097-57253635:+	ARL2BP	22;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007165,biological_process signal transduction;GO:0030496,cellular_component midbody;GO:0030695,molecular_function GTPase regulator activity;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042995,cellular_component cell projection;GO:0050790,biological_process regulation of catalytic activity;GO:0050796,biological_process regulation of insulin secretion;GO:0051457,biological_process maintenance of protein location in nucleus;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	ADP ribosylation factor like GTPase 2 binding protein [Source:HGNC Symbol%3BAcc:HGNC:17146]
ENSG00000162631	26.95	25.93	24.74	21.13	19.58	18.40	0.405652582016048	5.3157160908765	1.32384543675201e-07	1.60564535400662e-05	1:107140006-107483458:+	NTNG1	11;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0031225,cellular_component anchored component of membrane;GO:0046658,cellular_component anchored component of plasma membrane	NTNG1; netrin-G1; K07522	netrin G1 [Source:HGNC Symbol%3BAcc:HGNC:23319]
ENSG00000140937	0.60	0.85	1.14	0.20	0.32	0.16	1.91282749423313	0.617855737615412	1.3323247519752e-07	1.60564535400662e-05	16:64943752-65126112:-	CDH11	13;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021957,biological_process corticospinal tract morphogenesis;GO:0034332,biological_process adherens junction organization;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	cadherin 11 [Source:HGNC Symbol%3BAcc:HGNC:1750]
ENSG00000115380	20.85	19.02	20.59	14.45	12.85	16.17	0.488805832893121	4.69552407087588	1.45591225292904e-07	1.73771526880848e-05	2:55865966-55924139:-	EFEMP1	18;GO:0005006,molecular_function epidermal growth factor-activated receptor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007601,biological_process visual perception;GO:0008083,molecular_function growth factor activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0031012,cellular_component extracellular matrix;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0043010,biological_process camera-type eye development;GO:0048048,biological_process embryonic eye morphogenesis;GO:0048050,biological_process post-embryonic eye morphogenesis;GO:0070062,cellular_component extracellular exosome	NA	EGF containing fibulin like extracellular matrix protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3218]
ENSG00000166340	89.93	99.18	102.13	75.09	79.30	74.73	0.35747131535044	7.19716221804399	2.16263225291201e-07	2.55664325289494e-05	11:6612762-6619461:-	TPP1	25;GO:0004175,molecular_function endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0007040,biological_process lysosome organization;GO:0007399,biological_process nervous system development;GO:0007417,biological_process central nervous system development;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008240,molecular_function tripeptidyl-peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030163,biological_process protein catabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042277,molecular_function peptide binding;GO:0042470,cellular_component melanosome;GO:0043171,biological_process peptide catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0045453,biological_process bone resorption;GO:0046872,molecular_function metal ion binding;GO:0050885,biological_process neuromuscular process controlling balance;GO:0070062,cellular_component extracellular exosome	TPP1, CLN2; tripeptidyl-peptidase I [EC:3.4.14.9]; K01279	tripeptidyl peptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:2073]
ENSG00000101049	23.33	21.54	22.65	14.87	17.95	17.18	0.447553765847543	4.80465400193533	2.54435897302973e-07	2.97310039753075e-05	20:43558967-43588237:+	SGK2	26;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005246,molecular_function calcium channel regulator activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006979,biological_process response to oxidative stress;GO:0015459,molecular_function potassium channel regulator activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017080,molecular_function sodium channel regulator activity;GO:0017081,molecular_function chloride channel regulator activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032411,biological_process positive regulation of transporter activity;GO:0034220,biological_process ion transmembrane transport;GO:0035556,biological_process intracellular signal transduction;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process	SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]; K13303	SGK2%2C serine/threonine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:13900]
ENSG00000164120	11.71	10.24	14.15	7.28	7.21	7.23	0.753922369317281	3.14915249412566	2.56281110558117e-07	2.97310039753075e-05	4:174490176-174523154:-	HPGD	32;GO:0001822,biological_process kidney development;GO:0003824,molecular_function catalytic activity;GO:0004957,molecular_function prostaglandin E receptor activity;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007565,biological_process female pregnancy;GO:0007567,biological_process parturition;GO:0016323,cellular_component basolateral plasma membrane;GO:0016404,molecular_function 15-hydroxyprostaglandin dehydrogenase (NAD+) activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019372,biological_process lipoxygenase pathway;GO:0030728,biological_process ovulation;GO:0032355,biological_process response to estradiol;GO:0032496,biological_process response to lipopolysaccharide;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045471,biological_process response to ethanol;GO:0045786,biological_process negative regulation of cell cycle;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070403,molecular_function NAD+ binding;GO:0070493,biological_process thrombin receptor signaling pathway;GO:0097070,biological_process ductus arteriosus closure;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:2001300,biological_process lipoxin metabolic process	HPGD; 15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]; K00069	hydroxyprostaglandin dehydrogenase 15-(NAD) [Source:HGNC Symbol%3BAcc:HGNC:5154]
ENSG00000198727	5104.31	5137.17	5157.63	4237.52	4313.05	4240.84	0.279450072709702	12.3898229523647	2.61272362113421e-07	3.00293873232769e-05	MT:14746-15887:+	MT-CYB	37;GO:0001666,biological_process response to hypoxia;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0007584,biological_process response to nutrient;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0009055,molecular_function electron carrier activity;GO:0009408,biological_process response to heat;GO:0009636,biological_process response to toxic substance;GO:0009725,biological_process response to hormone;GO:0010243,biological_process response to organonitrogen compound;GO:0014070,biological_process response to organic cyclic compound;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0022904,biological_process respiratory electron transport chain;GO:0031100,biological_process organ regeneration;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0032403,molecular_function protein complex binding;GO:0033590,biological_process response to cobalamin;GO:0033762,biological_process response to glucagon;GO:0042493,biological_process response to drug;GO:0042538,biological_process hyperosmotic salinity response;GO:0043234,cellular_component protein complex;GO:0045275,cellular_component respiratory chain complex III;GO:0045471,biological_process response to ethanol;GO:0046686,biological_process response to cadmium ion;GO:0046688,biological_process response to copper ion;GO:0046689,biological_process response to mercury ion;GO:0046872,molecular_function metal ion binding;GO:0051592,biological_process response to calcium ion;GO:0055093,biological_process response to hyperoxia;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit; K00412	mitochondrially encoded cytochrome b [Source:HGNC Symbol%3BAcc:HGNC:7427]
ENSG00000241935	17.34	21.43	17.25	26.39	35.32	26.64	-0.651581808639292	4.5841715886267	2.74773696770742e-07	3.10106913083626e-05	10:97584322-97612802:+	HOGA1	15;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008152,biological_process metabolic process;GO:0008700,molecular_function 4-hydroxy-2-oxoglutarate aldolase activity;GO:0009436,biological_process glyoxylate catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0019470,biological_process 4-hydroxyproline catabolic process;GO:0033609,biological_process oxalate metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0042866,biological_process pyruvate biosynthetic process;GO:0046487,biological_process glyoxylate metabolic process;GO:0070062,cellular_component extracellular exosome	NA	4-hydroxy-2-oxoglutarate aldolase 1 [Source:HGNC Symbol%3BAcc:HGNC:25155]
ENSG00000105894	4.87	9.71	5.34	2.04	2.62	1.91	1.5812882839929	1.31010611638203	2.753131523676e-07	3.10106913083626e-05	7:137227340-137343865:-	PTN	67;GO:0001503,biological_process ossification;GO:0001889,biological_process liver development;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0007185,biological_process transmembrane receptor protein tyrosine phosphatase signaling pathway;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007612,biological_process learning;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014823,biological_process response to activity;GO:0016020,cellular_component membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0019901,molecular_function protein kinase binding;GO:0021510,biological_process spinal cord development;GO:0021549,biological_process cerebellum development;GO:0021794,biological_process thalamus development;GO:0030282,biological_process bone mineralization;GO:0030324,biological_process lung development;GO:0030336,biological_process negative regulation of cell migration;GO:0030902,biological_process hindbrain development;GO:0031594,cellular_component neuromuscular junction;GO:0032355,biological_process response to estradiol;GO:0032570,biological_process response to progesterone;GO:0034644,biological_process cellular response to UV;GO:0035373,molecular_function chondroitin sulfate proteoglycan binding;GO:0035374,molecular_function chondroitin sulfate binding;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0038085,molecular_function vascular endothelial growth factor binding;GO:0042493,biological_process response to drug;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0043394,molecular_function proteoglycan binding;GO:0044849,biological_process estrous cycle;GO:0045446,biological_process endothelial cell differentiation;GO:0045837,biological_process negative regulation of membrane potential;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051781,biological_process positive regulation of cell division;GO:0060041,biological_process retina development in camera-type eye;GO:0060221,biological_process retinal rod cell differentiation;GO:0060253,biological_process negative regulation of glial cell proliferation;GO:0060291,biological_process long-term synaptic potentiation;GO:0071305,biological_process cellular response to vitamin D;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071456,biological_process cellular response to hypoxia;GO:0072201,biological_process negative regulation of mesenchymal cell proliferation;GO:1904373,biological_process response to kainic acid;GO:1904389,biological_process rod bipolar cell differentiation;GO:1904391,biological_process response to ciliary neurotrophic factor;GO:1904395,biological_process positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:1904397,biological_process negative regulation of neuromuscular junction development;GO:1904399,molecular_function heparan sulfate binding;GO:1990089,biological_process response to nerve growth factor;GO:2000347,biological_process positive regulation of hepatocyte proliferation	NA	pleiotrophin [Source:HGNC Symbol%3BAcc:HGNC:9630]
ENSG00000152953	1.48	1.11	1.09	3.08	2.59	2.84	-1.18034814873602	1.48961631127109	2.77304981489427e-07	3.10106913083626e-05	4:5051441-5500998:+	STK32B	12;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	serine/threonine kinase 32B [Source:HGNC Symbol%3BAcc:HGNC:14217]
ENSG00000142089	668.08	631.94	727.39	523.77	513.30	563.18	0.353687551833371	8.07068536399552	2.98006130010924e-07	3.30281258198714e-05	11:319668-327537:-	IFITM3	22;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0009607,biological_process response to biotic stimulus;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane;GO:0032897,biological_process negative regulation of viral transcription;GO:0034341,biological_process response to interferon-gamma;GO:0035455,biological_process response to interferon-alpha;GO:0035456,biological_process response to interferon-beta;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0070062,cellular_component extracellular exosome	NA	interferon induced transmembrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:5414]
ENSG00000185339	81.82	83.78	80.21	60.55	70.10	61.32	0.368129425740173	6.5482350124255	3.18661359366671e-07	3.50048093258273e-05	22:30606837-30627278:+	TCN2	13;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006824,biological_process cobalt ion transport;GO:0009235,biological_process cobalamin metabolic process;GO:0015889,biological_process cobalamin transport;GO:0031419,molecular_function cobalamin binding;GO:0043202,cellular_component lysosomal lumen;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	TCN2; transcobalamin-2; K14619	transcobalamin 2 [Source:HGNC Symbol%3BAcc:HGNC:11653]
ENSG00000103381	31.34	28.71	28.83	38.47	39.05	39.34	-0.380090700632648	5.02463766419427	3.23844887315304e-07	3.52621630372357e-05	16:12659798-12804017:-	CPPED1	11;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	calcineurin like phosphoesterase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25632]
ENSG00000165617	3.60	2.36	3.49	1.73	1.30	1.82	0.984342162925121	2.62384816984336	3.72376899295617e-07	4.01940387039695e-05	14:58633966-58648321:+	DACT1	34;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008013,molecular_function beta-catenin binding;GO:0016055,biological_process Wnt signaling pathway;GO:0021915,biological_process neural tube development;GO:0030054,cellular_component cell junction;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030877,cellular_component beta-catenin destruction complex;GO:0031647,biological_process regulation of protein stability;GO:0032091,biological_process negative regulation of protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0035412,biological_process regulation of catenin import into nucleus;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0042826,molecular_function histone deacetylase binding;GO:0045202,cellular_component synapse;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046329,biological_process negative regulation of JNK cascade;GO:0048619,biological_process embryonic hindgut morphogenesis;GO:0051018,molecular_function protein kinase A binding;GO:0070097,molecular_function delta-catenin binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:1904864,biological_process negative regulation of beta-catenin-TCF complex assembly;GO:2000095,biological_process regulation of Wnt signaling pathway, planar cell polarity pathway;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	dishevelled binding antagonist of beta catenin 1 [Source:HGNC Symbol%3BAcc:HGNC:17748]
ENSG00000182667	2.43	1.45	1.65	3.71	3.63	4.61	-1.07717680029796	1.95091458445268	3.76336298089303e-07	4.02712281739872e-05	11:131370477-132336822:+	NTM	8;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007155,biological_process cell adhesion;GO:0008038,biological_process neuron recognition;GO:0016020,cellular_component membrane;GO:0031225,cellular_component anchored component of membrane	NA	neurotrimin [Source:HGNC Symbol%3BAcc:HGNC:17941]
ENSG00000107518	0.66	0.76	0.77	1.29	1.59	1.29	-0.922873681315487	2.24275449676517	3.83227797502373e-07	4.06581764991193e-05	10:115093364-115948992:+	ATRNL1	4;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding	NA	attractin like 1 [Source:HGNC Symbol%3BAcc:HGNC:29063]
ENSG00000189077	26.66	26.34	26.90	20.41	21.41	20.43	0.372811183190118	5.00040943258996	3.95642318365719e-07	4.16195601514718e-05	7:75986836-75994659:-	TMEM120A	10;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045444,biological_process fat cell differentiation;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization	NA	transmembrane protein 120A [Source:HGNC Symbol%3BAcc:HGNC:21697]
ENSG00000258818	35.87	31.21	31.21	18.68	20.12	24.71	0.642088572590687	3.58854837501848	4.05460370789258e-07	4.22939460723282e-05	14:20684099-20701215:+	RNASE4	11;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004522,molecular_function ribonuclease A activity;GO:0004540,molecular_function ribonuclease activity;GO:0005576,cellular_component extracellular region;GO:0006379,biological_process mRNA cleavage;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	ribonuclease A family member 4 [Source:HGNC Symbol%3BAcc:HGNC:10047]
ENSG00000135636	5.44	5.16	5.51	7.76	6.75	6.87	-0.393164186489582	5.35024052814469	4.3575826789471e-07	4.50589219214568e-05	2:71453721-71686768:+	DYSF	23;GO:0001778,biological_process plasma membrane repair;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005815,cellular_component microtubule organizing center;GO:0005886,cellular_component plasma membrane;GO:0006906,biological_process vesicle fusion;GO:0006936,biological_process muscle contraction;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030027,cellular_component lamellipodium;GO:0030139,cellular_component endocytic vesicle;GO:0030315,cellular_component T-tubule;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042383,cellular_component sarcolemma;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	dysferlin [Source:HGNC Symbol%3BAcc:HGNC:3097]
ENSG00000148702	18.03	17.92	17.48	6.77	13.68	8.96	0.873723167096385	4.537960497176	4.39227386811913e-07	4.50589219214568e-05	10:113550836-113589602:+	HABP2	10;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0007155,biological_process cell adhesion;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity	NA	hyaluronan binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4798]
ENSG00000072210	25.90	24.82	26.75	20.42	17.35	21.08	0.409146551470945	5.33899771959784	4.45592268767218e-07	4.53371871492416e-05	17:19648135-19677598:+	ALDH3A2	22;GO:0001561,biological_process fatty acid alpha-oxidation;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0004030,molecular_function aldehyde dehydrogenase [NAD(P)+] activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0007417,biological_process central nervous system development;GO:0007422,biological_process peripheral nervous system development;GO:0008152,biological_process metabolic process;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0033306,biological_process phytol metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046577,molecular_function long-chain-alcohol oxidase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]; K00128	aldehyde dehydrogenase 3 family member A2 [Source:HGNC Symbol%3BAcc:HGNC:403]
ENSG00000182985	25.34	24.41	23.87	18.29	20.40	18.22	0.384465704364257	5.14822989141458	4.58490627729576e-07	4.62702777398961e-05	11:115169217-115504957:-	CADM1	30;GO:0002376,biological_process immune system process;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0006915,biological_process apoptotic process;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008037,biological_process cell recognition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030165,molecular_function PDZ domain binding;GO:0034332,biological_process adherens junction organization;GO:0042271,biological_process susceptibility to natural killer cell mediated cytotoxicity;GO:0042803,molecular_function protein homodimerization activity;GO:0045202,cellular_component synapse;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051606,biological_process detection of stimulus;GO:0070062,cellular_component extracellular exosome	CADM1, IGSF4, NECL2, TSLC1; cell adhesion molecule 1; K06781	cell adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:5951]
ENSG00000138646	9.20	9.24	9.32	11.50	12.39	12.29	-0.371227692197979	5.04302720903307	5.473818266098e-07	5.47955694653827e-05	4:88457116-88506163:+	HERC5	18;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000209,biological_process protein polyubiquitination;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032020,biological_process ISG15-protein conjugation;GO:0032480,biological_process negative regulation of type I interferon production;GO:0042296,molecular_function ISG15 transferase activity;GO:0045087,biological_process innate immune response;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050688,biological_process regulation of defense response to virus;GO:0051607,biological_process defense response to virus;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	HECT and RLD domain containing E3 ubiquitin protein ligase 5 [Source:HGNC Symbol%3BAcc:HGNC:24368]
ENSG00000166224	31.66	29.64	31.43	41.65	36.91	40.41	-0.345840272704351	5.9921110920958	5.64950608363812e-07	5.610185521296e-05	10:70815960-70881173:+	SGPL1	37;GO:0001553,biological_process luteinization;GO:0001570,biological_process vasculogenesis;GO:0001822,biological_process kidney development;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006672,biological_process ceramide metabolic process;GO:0006807,biological_process nitrogen compound metabolic process;GO:0006915,biological_process apoptotic process;GO:0007283,biological_process spermatogenesis;GO:0008117,molecular_function sphinganine-1-phosphate aldolase activity;GO:0008209,biological_process androgen metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0008585,biological_process female gonad development;GO:0009791,biological_process post-embryonic development;GO:0010761,biological_process fibroblast migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030097,biological_process hemopoiesis;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030149,biological_process sphingolipid catabolic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0033327,biological_process Leydig cell differentiation;GO:0040014,biological_process regulation of multicellular organism growth;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048705,biological_process skeletal system morphogenesis;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis;GO:0097190,biological_process apoptotic signaling pathway	SGPL1, DPL1; sphinganine-1-phosphate aldolase [EC:4.1.2.27]; K01634	sphingosine-1-phosphate lyase 1 [Source:HGNC Symbol%3BAcc:HGNC:10817]
ENSG00000012504	19.64	21.94	22.12	13.60	16.43	16.73	0.455190497094221	4.9630017218308	5.71055047905916e-07	5.62579865845725e-05	12:100473707-100564413:+	NR1H4	82;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001080,biological_process nitrogen catabolite activation of transcription from RNA polymerase II promoter;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004887,molecular_function thyroid hormone receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005719,cellular_component nuclear euchromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007043,biological_process cell-cell junction assembly;GO:0007165,biological_process signal transduction;GO:0007219,biological_process Notch signaling pathway;GO:0008206,biological_process bile acid metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010988,biological_process regulation of low-density lipoprotein particle clearance;GO:0015721,biological_process bile acid and bile salt transport;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032052,molecular_function bile acid binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032692,biological_process negative regulation of interleukin-1 production;GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0034255,biological_process regulation of urea metabolic process;GO:0034971,biological_process histone H3-R17 methylation;GO:0035356,biological_process cellular triglyceride homeostasis;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0038181,molecular_function bile acid receptor activity;GO:0038183,biological_process bile acid signaling pathway;GO:0038185,biological_process intracellular bile acid receptor signaling pathway;GO:0042593,biological_process glucose homeostasis;GO:0042742,biological_process defense response to bacterium;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0055089,biological_process fatty acid homeostasis;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070328,biological_process triglyceride homeostasis;GO:0070857,biological_process regulation of bile acid biosynthetic process;GO:0070858,biological_process negative regulation of bile acid biosynthetic process;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071398,biological_process cellular response to fatty acid;GO:0071417,biological_process cellular response to organonitrogen compound;GO:0071638,biological_process negative regulation of monocyte chemotactic protein-1 production;GO:0072615,biological_process interleukin-17 secretion;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:1902122,molecular_function chenodeoxycholic acid binding;GO:1902714,biological_process negative regulation of interferon-gamma secretion;GO:1904179,biological_process positive regulation of adipose tissue development;GO:1904468,biological_process negative regulation of tumor necrosis factor secretion;GO:1905695,biological_process positive regulation of phosphatidic acid biosynthetic process;GO:2000188,biological_process regulation of cholesterol homeostasis;GO:2000213,biological_process positive regulation of glutamate metabolic process;GO:2001250,biological_process positive regulation of ammonia assimilation cycle;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	NR1H4, FXR; farnesoid X receptor; K08537	nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol%3BAcc:HGNC:7967]
ENSG00000179954	4.40	3.79	4.69	3.22	2.92	2.95	0.522236007259041	4.14488816654901	6.76802590467084e-07	6.61507917753379e-05	19:55488403-55519098:+	SSC5D	21;GO:0001968,molecular_function fibronectin binding;GO:0002376,biological_process immune system process;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006952,biological_process defense response;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0031012,cellular_component extracellular matrix;GO:0042494,biological_process detection of bacterial lipoprotein;GO:0043236,molecular_function laminin binding;GO:0045087,biological_process innate immune response;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0050840,molecular_function extracellular matrix binding;GO:2000482,biological_process regulation of interleukin-8 secretion;GO:2000483,biological_process negative regulation of interleukin-8 secretion	NA	scavenger receptor cysteine rich family member with 5 domains [Source:HGNC Symbol%3BAcc:HGNC:26641]
ENSG00000087303	93.59	94.55	96.58	74.09	81.36	77.43	0.301797483442454	8.47684809147194	7.48216322639275e-07	7.25594469759478e-05	14:52004802-52069228:-	NID2	14;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome;GO:0071711,biological_process basement membrane organization	NA	nidogen 2 [Source:HGNC Symbol%3BAcc:HGNC:13389]
ENSG00000171311	58.01	48.93	57.75	73.44	73.06	70.65	-0.379946809372644	5.32925362369479	8.95388626631422e-07	8.6158597072681e-05	10:97436141-97446017:-	EXOSC1	12;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	CSL4, EXOSC1; exosome complex component CSL4; K07573	exosome component 1 [Source:HGNC Symbol%3BAcc:HGNC:17286]
ENSG00000130513	30.12	28.03	38.08	48.38	42.60	46.27	-0.495761126853735	5.18072899124407	9.95456875639409e-07	9.50508169023999e-05	19:18374730-18389176:+	GDF15	19;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0008083,molecular_function growth factor activity;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030509,biological_process BMP signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0048468,biological_process cell development;GO:0060395,biological_process SMAD protein signal transduction;GO:0070062,cellular_component extracellular exosome;GO:1901741,biological_process positive regulation of myoblast fusion	GDF15; growth differentiation factor 15; K05504	growth differentiation factor 15 [Source:HGNC Symbol%3BAcc:HGNC:30142]
ENSG00000124568	5.80	4.91	6.30	7.96	9.20	9.79	-0.641628248299948	3.39441535815369	1.00814998585902e-06	9.55279830112059e-05	6:25782896-25832059:-	SLC17A1	17;GO:0005436,molecular_function sodium:phosphate symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006817,biological_process phosphate ion transport;GO:0015114,molecular_function phosphate ion transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015321,molecular_function sodium-dependent phosphate transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0044341,biological_process sodium-dependent phosphate transport;GO:0046415,biological_process urate metabolic process;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 17 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10929]
ENSG00000117152	4.40	7.00	4.99	2.13	2.82	2.61	1.10356129764149	1.89194659910418	1.08107109042044e-06	0.000101661632162037	1:163068774-163076802:+	RGS4	15;GO:0000188,biological_process inactivation of MAPK activity;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005096,molecular_function GTPase activator activity;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway	NA	regulator of G protein signaling 4 [Source:HGNC Symbol%3BAcc:HGNC:10000]
ENSG00000165359	7.42	6.35	7.38	4.72	4.98	5.40	0.502580650436633	4.03942060835869	1.18558262114297e-06	0.000110651406588328	X:135520642-135582510:+	INTS6L	NA	NA	integrator complex subunit 6 like [Source:HGNC Symbol%3BAcc:HGNC:27334]
ENSG00000033100	20.54	23.39	18.23	15.44	16.15	14.12	0.451112324674064	5.42499886383234	1.2328740865859e-06	0.000114206462961125	7:151232488-151238827:+	CHPF2	9;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0050510,molecular_function N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHPF2; chondroitin polymerizing factor 2 [EC:2.4.1.226]; K03419	chondroitin polymerizing factor 2 [Source:HGNC Symbol%3BAcc:HGNC:29270]
ENSG00000104805	206.07	209.41	213.93	174.57	172.58	176.25	0.277831205188216	8.2031911508375	1.37148960923451e-06	0.000126105929773541	19:48900049-48923372:+	NUCB1	26;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0003677,molecular_function DNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0016020,cellular_component membrane;GO:0032580,cellular_component Golgi cisterna membrane;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0072718,biological_process response to cisplatin;GO:0090498,cellular_component extrinsic component of Golgi membrane;GO:0098547,cellular_component lumenal side of Golgi membrane;GO:1903533,biological_process regulation of protein targeting	NA	nucleobindin 1 [Source:HGNC Symbol%3BAcc:HGNC:8043]
ENSG00000107819	138.71	142.06	152.14	191.49	171.35	184.70	-0.327006617987021	7.35356680506442	1.55697098023747e-06	0.000142107946894762	10:101031233-101041244:+	SFXN3	10;GO:0005739,cellular_component mitochondrion;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0034220,biological_process ion transmembrane transport;GO:0055072,biological_process iron ion homeostasis;GO:0055085,biological_process transmembrane transport	NA	sideroflexin 3 [Source:HGNC Symbol%3BAcc:HGNC:16087]
ENSG00000175040	4.35	4.39	4.07	2.07	2.86	2.57	0.781095162304188	2.45780651040145	1.60301812002762e-06	0.000145242802364255	3:143119330-143124014:+	CHST2	15;GO:0000139,cellular_component Golgi membrane;GO:0001517,molecular_function N-acetylglucosamine 6-O-sulfotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005975,biological_process carbohydrate metabolic process;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006790,biological_process sulfur compound metabolic process;GO:0006954,biological_process inflammatory response;GO:0007275,biological_process multicellular organism development;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0031228,cellular_component intrinsic component of Golgi membrane	CHST2; carbohydrate 6-sulfotransferase 2 [EC:2.8.2.-]; K04745	carbohydrate sulfotransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:1970]
ENSG00000063660	47.14	49.26	45.94	38.64	39.41	37.77	0.307814970012732	6.2040936152933	1.63224456080742e-06	0.000146819215458714	2:240435670-240468078:+	GPC1	29;GO:0001523,biological_process retinoid metabolic process;GO:0005507,molecular_function copper ion binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005796,cellular_component Golgi lumen;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0007411,biological_process axon guidance;GO:0014037,biological_process Schwann cell differentiation;GO:0016020,cellular_component membrane;GO:0017134,molecular_function fibroblast growth factor binding;GO:0030200,biological_process heparan sulfate proteoglycan catabolic process;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0031225,cellular_component anchored component of membrane;GO:0032288,biological_process myelin assembly;GO:0040037,biological_process negative regulation of fibroblast growth factor receptor signaling pathway;GO:0043202,cellular_component lysosomal lumen;GO:0043236,molecular_function laminin binding;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0045121,cellular_component membrane raft;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:2001016,biological_process positive regulation of skeletal muscle cell differentiation	GPC1; glypican 1; K08107	glypican 1 [Source:HGNC Symbol%3BAcc:HGNC:4449]
ENSG00000137745	2.29	1.24	2.05	0.87	0.59	0.68	1.40949167569859	1.10606179150322	1.85126594041408e-06	0.000165322044016979	11:102942994-102955734:-	MMP13	23;GO:0001958,biological_process endochondral ossification;GO:0003417,biological_process growth plate cartilage development;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030282,biological_process bone mineralization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051216,biological_process cartilage development;GO:0060349,biological_process bone morphogenesis	MMP13; matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]; K07994	matrix metallopeptidase 13 [Source:HGNC Symbol%3BAcc:HGNC:7159]
ENSG00000163082	20.59	17.09	19.49	25.58	24.33	29.84	-0.463217778520667	4.78780772574291	1.93354087453563e-06	0.000171436020540077	2:222424516-222560948:+	SGPP2	10;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006670,biological_process sphingosine metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0042392,molecular_function sphingosine-1-phosphate phosphatase activity;GO:0070780,molecular_function dihydrosphingosine-1-phosphate phosphatase activity	SGPP2; sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-]; K04717	sphingosine-1-phosphate phosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:19953]
ENSG00000125848	2.10	2.70	2.04	0.58	1.48	0.72	1.30354996533687	1.67854601206695	1.96805736600282e-06	0.000173258837476546	20:14322987-14337616:-	FLRT3	43;GO:0003345,biological_process proepicardium cell migration involved in pericardium morphogenesis;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005104,molecular_function fibroblast growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0007416,biological_process synapse assembly;GO:0007507,biological_process heart development;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030674,molecular_function protein binding, bridging;GO:0031175,biological_process neuron projection development;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043679,cellular_component axon terminus;GO:0044295,cellular_component axonal growth cone;GO:0045499,molecular_function chemorepellent activity;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0048598,biological_process embryonic morphogenesis;GO:0048678,biological_process response to axon injury;GO:0050919,biological_process negative chemotaxis;GO:0051965,biological_process positive regulation of synapse assembly;GO:0060322,biological_process head development;GO:0097060,cellular_component synaptic membrane;GO:0098742,biological_process cell-cell adhesion via plasma-membrane adhesion molecules;GO:1990138,biological_process neuron projection extension	NA	fibronectin leucine rich transmembrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:3762]
ENSG00000123384	26.06	23.58	26.76	20.57	20.57	21.18	0.306206509893271	8.32468874476962	2.07133292205272e-06	0.000179588565243961	12:57128492-57213351:+	LRP1	75;GO:0001523,biological_process retinoid metabolic process;GO:0002020,molecular_function protease binding;GO:0002265,biological_process astrocyte activation involved in immune response;GO:0003723,molecular_function RNA binding;GO:0004872,molecular_function receptor activity;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005925,cellular_component focal adhesion;GO:0006629,biological_process lipid metabolic process;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006909,biological_process phagocytosis;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007568,biological_process aging;GO:0008283,biological_process cell proliferation;GO:0010715,biological_process regulation of extracellular matrix disassembly;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0010942,biological_process positive regulation of cell death;GO:0010977,biological_process negative regulation of neuron projection development;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016964,molecular_function alpha-2 macroglobulin receptor activity;GO:0021987,biological_process cerebral cortex development;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030226,molecular_function apolipoprotein receptor activity;GO:0030425,cellular_component dendrite;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031623,biological_process receptor internalization;GO:0032050,molecular_function clathrin heavy chain binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032370,biological_process positive regulation of lipid transport;GO:0032374,biological_process regulation of cholesterol transport;GO:0032403,molecular_function protein complex binding;GO:0032429,biological_process regulation of phospholipase A2 activity;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0034185,molecular_function apolipoprotein binding;GO:0035909,biological_process aorta morphogenesis;GO:0042157,biological_process lipoprotein metabolic process;GO:0042953,biological_process lipoprotein transport;GO:0042954,molecular_function lipoprotein transporter activity;GO:0043025,cellular_component neuronal cell body;GO:0043235,cellular_component receptor complex;GO:0043277,biological_process apoptotic cell clearance;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045056,biological_process transcytosis;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045807,biological_process positive regulation of endocytosis;GO:0046872,molecular_function metal ion binding;GO:0051222,biological_process positive regulation of protein transport;GO:0051246,biological_process regulation of protein metabolic process;GO:0070325,molecular_function lipoprotein particle receptor binding;GO:0097242,biological_process beta-amyloid clearance;GO:0098797,cellular_component plasma membrane protein complex;GO:1900223,biological_process positive regulation of beta-amyloid clearance;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:1904646,biological_process cellular response to beta-amyloid;GO:1905167,biological_process positive regulation of lysosomal protein catabolic process;GO:2000587,biological_process negative regulation of platelet-derived growth factor receptor-beta signaling pathway	LRP1, CD91; low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor); K04550	LDL receptor related protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6692]
ENSG00000102265	250.36	255.98	259.38	205.90	210.84	217.68	0.283022041286343	7.66405677813911	2.0829374092043e-06	0.000179588565243961	X:47582312-47586789:+	TIMP1	39;GO:0001775,biological_process cell activation;GO:0002020,molecular_function protease binding;GO:0002576,biological_process platelet degranulation;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007568,biological_process aging;GO:0008083,molecular_function growth factor activity;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009725,biological_process response to hormone;GO:0010033,biological_process response to organic substance;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031012,cellular_component extracellular matrix;GO:0031093,cellular_component platelet alpha granule lumen;GO:0034097,biological_process response to cytokine;GO:0042060,biological_process wound healing;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043434,biological_process response to peptide hormone;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051045,biological_process negative regulation of membrane protein ectodomain proteolysis;GO:0051216,biological_process cartilage development;GO:0070062,cellular_component extracellular exosome;GO:1901164,biological_process negative regulation of trophoblast cell migration;GO:1905049,biological_process negative regulation of metallopeptidase activity;GO:2001044,biological_process regulation of integrin-mediated signaling pathway	TIMP1; metalloproteinase inhibitor 1; K16451	TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:11820]
ENSG00000013563	18.94	20.25	19.58	14.63	14.48	14.05	0.453939425282307	3.9526552276398	2.08336046041492e-06	0.000179588565243961	X:154401237-154412112:-	DNASE1L1	14;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004536,molecular_function deoxyribonuclease activity;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0006259,biological_process DNA metabolic process;GO:0006308,biological_process DNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	deoxyribonuclease 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:2957]
ENSG00000182557	11.86	11.07	12.51	16.52	14.86	17.17	-0.438532410179971	4.44360830236806	2.12131957538727e-06	0.000181599585443326	17:4433687-4488208:+	SPNS3	10;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031982,cellular_component vesicle;GO:0040011,biological_process locomotion;GO:0046624,molecular_function sphingolipid transporter activity;GO:0055085,biological_process transmembrane transport	NA	sphingolipid transporter 3 (putative) [Source:HGNC Symbol%3BAcc:HGNC:28433]
ENSG00000080986	34.07	33.68	32.46	40.70	43.33	40.80	-0.305376212701057	6.4158932564502	2.36691816958242e-06	0.00020123667971936	18:2571510-2616635:+	NDC80	28;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000942,cellular_component condensed nuclear chromosome outer kinetochore;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0016020,cellular_component membrane;GO:0031262,cellular_component Ndc80 complex;GO:0042802,molecular_function identical protein binding;GO:0051301,biological_process cell division;GO:0051310,biological_process metaphase plate congression;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0051383,biological_process kinetochore organization;GO:0090267,biological_process positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:1905342,biological_process positive regulation of protein localization to kinetochore	NA	NDC80%2C kinetochore complex component [Source:HGNC Symbol%3BAcc:HGNC:16909]
ENSG00000117984	154.18	155.88	167.19	117.50	137.31	127.26	0.33298423840096	7.62562082218209	2.76810877164317e-06	0.000233745130492562	11:1752751-1764573:-	CTSD	23;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0006914,biological_process autophagy;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030163,biological_process protein catabolic process;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035580,cellular_component specific granule lumen;GO:0042470,cellular_component melanosome;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045121,cellular_component membrane raft;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	CTSD; cathepsin D [EC:3.4.23.5]; K01379	cathepsin D [Source:HGNC Symbol%3BAcc:HGNC:2529]
ENSG00000143889	12.62	11.51	12.68	9.23	9.09	9.36	0.42747146618702	4.23269648298958	2.85297843288012e-06	0.000239283927617169	2:38561977-38603586:-	HNRNPLL	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0016020,cellular_component membrane;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033120,biological_process positive regulation of RNA splicing	NA	heterogeneous nuclear ribonucleoprotein L like [Source:HGNC Symbol%3BAcc:HGNC:25127]
ENSG00000107798	76.35	80.07	74.48	62.67	65.11	59.53	0.312527718070544	6.45609147211623	2.87445728894996e-06	0.000239467371327086	10:89213568-89414557:-	LIPA	19;GO:0000902,biological_process cell morphogenesis;GO:0001650,cellular_component fibrillar center;GO:0001816,biological_process cytokine production;GO:0004771,molecular_function sterol esterase activity;GO:0005764,cellular_component lysosome;GO:0006629,biological_process lipid metabolic process;GO:0006954,biological_process inflammatory response;GO:0008283,biological_process cell proliferation;GO:0016042,biological_process lipid catabolic process;GO:0016298,molecular_function lipase activity;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0030324,biological_process lung development;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048771,biological_process tissue remodeling;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0070062,cellular_component extracellular exosome	LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13]; K01052	lipase A%2C lysosomal acid type [Source:HGNC Symbol%3BAcc:HGNC:6617]
ENSG00000148346	1.86	1.89	1.21	5.30	3.62	4.05	-1.3791601575676	0.990840058547549	2.92022744416603e-06	0.00024165855509622	9:128149070-128153455:+	LCN2	36;GO:0002020,molecular_function protease binding;GO:0002376,biological_process immune system process;GO:0005215,molecular_function transporter activity;GO:0005506,molecular_function iron ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0009615,biological_process response to virus;GO:0009617,biological_process response to bacterium;GO:0009635,biological_process response to herbicide;GO:0010046,biological_process response to mycotoxin;GO:0010628,biological_process positive regulation of gene expression;GO:0015891,biological_process siderophore transport;GO:0019730,biological_process antimicrobial humoral response;GO:0031346,biological_process positive regulation of cell projection organization;GO:0031667,biological_process response to nutrient levels;GO:0031669,biological_process cellular response to nutrient levels;GO:0035580,cellular_component specific granule lumen;GO:0036094,molecular_function small molecule binding;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0055072,biological_process iron ion homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0070207,biological_process protein homotrimerization;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand	NA	lipocalin 2 [Source:HGNC Symbol%3BAcc:HGNC:6526]
ENSG00000136167	2.55	2.44	2.19	1.39	0.44	1.23	1.2274465546961	1.73781351471068	3.26207702359391e-06	0.000268160013866697	13:46125919-46211871:-	LCP1	36;GO:0001725,cellular_component stress fiber;GO:0001726,cellular_component ruffle;GO:0001891,cellular_component phagocytic cup;GO:0002102,cellular_component podosome;GO:0002286,biological_process T cell activation involved in immune response;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0010737,biological_process protein kinase A signaling;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0022617,biological_process extracellular matrix disassembly;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0031100,biological_process organ regeneration;GO:0032432,cellular_component actin filament bundle;GO:0032587,cellular_component ruffle membrane;GO:0033157,biological_process regulation of intracellular protein transport;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051020,molecular_function GTPase binding;GO:0051639,biological_process actin filament network formation;GO:0051764,biological_process actin crosslink formation;GO:0070062,cellular_component extracellular exosome;GO:0071803,biological_process positive regulation of podosome assembly	NA	lymphocyte cytosolic protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6528]
ENSG00000165521	1.00	0.82	1.00	1.52	1.37	1.67	-0.670253542931585	2.92187335525978	3.28950673091598e-06	0.000268635835860922	14:88612430-88792752:-	EML5	9;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0008150,biological_process biological_process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0070062,cellular_component extracellular exosome	NA	echinoderm microtubule associated protein like 5 [Source:HGNC Symbol%3BAcc:HGNC:18197]
ENSG00000173511	68.08	66.82	69.28	52.47	58.39	52.13	0.338579855438877	5.35133988008226	3.66906700646362e-06	0.000297674044125706	11:64234537-64238793:+	VEGFB	26;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0006493,biological_process protein O-linked glycosylation;GO:0007507,biological_process heart development;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0016020,cellular_component membrane;GO:0031093,cellular_component platelet alpha granule lumen;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043183,molecular_function vascular endothelial growth factor receptor 1 binding;GO:0043184,molecular_function vascular endothelial growth factor receptor 2 binding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046982,molecular_function protein heterodimerization activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0050930,biological_process induction of positive chemotaxis;GO:0051781,biological_process positive regulation of cell division;GO:0060048,biological_process cardiac muscle contraction;GO:0060754,biological_process positive regulation of mast cell chemotaxis;GO:0060976,biological_process coronary vasculature development	VEGFB; vascular endothelial growth factor B; K16858	vascular endothelial growth factor B [Source:HGNC Symbol%3BAcc:HGNC:12681]
ENSG00000119943	35.21	33.94	37.54	44.72	42.16	49.74	-0.343886768098948	6.14941873946744	3.97080492542132e-06	0.000320062347657499	10:98383564-98415184:-	PYROXD2	4;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	pyridine nucleotide-disulphide oxidoreductase domain 2 [Source:HGNC Symbol%3BAcc:HGNC:23517]
ENSG00000145247	243.98	225.05	232.11	300.62	273.33	301.67	-0.307863803242933	6.9274575930124	4.47984710060815e-06	0.000356570731044086	4:48885018-48906937:-	OCIAD2	3;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005768,cellular_component endosome	NA	OCIA domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28685]
ENSG00000168268	115.92	129.70	116.89	90.35	102.81	97.82	0.328114297503421	7.74948844111287	4.48119181848686e-06	0.000356570731044086	3:52524384-52535054:-	NT5DC2	4;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	5'-nucleotidase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25717]
ENSG00000166825	147.84	137.77	146.88	123.91	110.81	120.35	0.296571751351598	8.59351157442823	4.75617540953826e-06	0.00037604079846241	15:89784888-89815401:-	ANPEP	31;GO:0001525,biological_process angiogenesis;GO:0001618,molecular_function virus receptor activity;GO:0004177,molecular_function aminopeptidase activity;GO:0004872,molecular_function receptor activity;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005765,cellular_component lysosomal membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0008217,biological_process regulation of blood pressure;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0030667,cellular_component secretory granule membrane;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome	ANPEP, CD13; aminopeptidase N [EC:3.4.11.2]; K11140	alanyl aminopeptidase%2C membrane [Source:HGNC Symbol%3BAcc:HGNC:500]
ENSG00000182132	19.37	21.00	16.69	25.36	26.84	25.45	-0.439532762475303	4.48834569648159	4.95262130864268e-06	0.000389094229773301	5:170353486-170736632:+	KCNIP1	21;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0030425,cellular_component dendrite;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0061337,biological_process cardiac conduction;GO:0065009,biological_process regulation of molecular function;GO:0071805,biological_process potassium ion transmembrane transport;GO:1901379,biological_process regulation of potassium ion transmembrane transport	NA	potassium voltage-gated channel interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15521]
ENSG00000116667	14.79	13.43	15.61	8.66	6.06	9.49	0.867160755439227	2.09022527163138	4.98861640686428e-06	0.000389426257232819	1:184387057-184629020:+	C1orf21	1;GO:0005515,molecular_function protein binding	NA	chromosome 1 open reading frame 21 [Source:HGNC Symbol%3BAcc:HGNC:15494]
ENSG00000180210	1.59	2.10	1.69	0.98	0.51	0.92	1.14238952823386	1.37217301031724	5.01959245607436e-06	0.000389426257232819	11:46719179-46739506:+	F2	58;GO:0001530,molecular_function lipopolysaccharide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006953,biological_process acute-phase response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007596,biological_process blood coagulation;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0007599,biological_process hemostasis;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009611,biological_process response to wounding;GO:0009897,cellular_component external side of plasma membrane;GO:0010468,biological_process regulation of gene expression;GO:0010544,biological_process negative regulation of platelet activation;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016787,molecular_function hydrolase activity;GO:0017187,biological_process peptidyl-glutamic acid carboxylation;GO:0030168,biological_process platelet activation;GO:0030193,biological_process regulation of blood coagulation;GO:0030194,biological_process positive regulation of blood coagulation;GO:0030307,biological_process positive regulation of cell growth;GO:0030449,biological_process regulation of complement activation;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0042730,biological_process fibrinolysis;GO:0044267,biological_process cellular protein metabolic process;GO:0045861,biological_process negative regulation of proteolysis;GO:0048712,biological_process negative regulation of astrocyte differentiation;GO:0050900,biological_process leukocyte migration;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0051838,biological_process cytolysis by host of symbiont cells;GO:0051918,biological_process negative regulation of fibrinolysis;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070053,molecular_function thrombospondin receptor activity;GO:0070062,cellular_component extracellular exosome;GO:0070945,biological_process neutrophil mediated killing of gram-negative bacterium;GO:0072562,cellular_component blood microparticle;GO:0090218,biological_process positive regulation of lipid kinase activity;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1900738,biological_process positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	F2; coagulation factor II (thrombin) [EC:3.4.21.5]; K01313	coagulation factor II%2C thrombin [Source:HGNC Symbol%3BAcc:HGNC:3535]
ENSG00000186480	102.37	137.07	88.69	65.04	84.73	64.99	0.621842626833442	6.48221896268416	5.08900008606896e-06	0.000392358745766298	7:155297775-155310235:+	INSIG1	24;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006991,biological_process response to sterol depletion;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008283,biological_process cell proliferation;GO:0010894,biological_process negative regulation of steroid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0032933,biological_process SREBP signaling pathway;GO:0032937,cellular_component SREBP-SCAP-Insig complex;GO:0042472,biological_process inner ear morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0060021,biological_process palate development;GO:0060363,biological_process cranial suture morphogenesis;GO:1901303,biological_process negative regulation of cargo loading into COPII-coated vesicle	NA	insulin induced gene 1 [Source:HGNC Symbol%3BAcc:HGNC:6083]
ENSG00000170581	36.67	35.45	37.42	29.59	30.55	30.49	0.286256465106098	6.44397229260883	5.15483629437803e-06	0.000394981376062435	12:56341596-56360155:-	STAT2	21;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007259,biological_process JAK-STAT cascade;GO:0016032,biological_process viral process;GO:0042802,molecular_function identical protein binding;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0090140,biological_process regulation of mitochondrial fission	STAT2; signal transducer and activator of transcription 2; K11221	signal transducer and activator of transcription 2 [Source:HGNC Symbol%3BAcc:HGNC:11363]
ENSG00000197324	76.64	75.86	77.45	64.90	64.78	61.28	0.280199776503525	7.23151077419738	5.45919625929843e-06	0.00041573621574645	14:22871612-22881580:+	LRP10	9;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005905,cellular_component clathrin-coated pit;GO:0006629,biological_process lipid metabolic process;GO:0006869,biological_process lipid transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0048839,biological_process inner ear development	NA	LDL receptor related protein 10 [Source:HGNC Symbol%3BAcc:HGNC:14553]
ENSG00000085063	218.40	233.24	208.66	168.77	191.73	158.04	0.359662965782569	6.8968635706281	5.53083155480748e-06	0.000418623244450154	11:33698260-33736445:-	CD59	31;GO:0000139,cellular_component Golgi membrane;GO:0001775,biological_process cell activation;GO:0001848,molecular_function complement binding;GO:0001971,biological_process negative regulation of activation of membrane attack complex;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007596,biological_process blood coagulation;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0030133,cellular_component transport vesicle;GO:0030449,biological_process regulation of complement activation;GO:0031225,cellular_component anchored component of membrane;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0031982,cellular_component vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035579,cellular_component specific granule membrane;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042383,cellular_component sarcolemma;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043218,cellular_component compact myelin;GO:0043312,biological_process neutrophil degranulation;GO:0048208,biological_process COPII vesicle coating;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane	CD59; CD59 antigen; K04008	CD59 molecule (CD59 blood group) [Source:HGNC Symbol%3BAcc:HGNC:1689]
ENSG00000186867	0.71	1.61	0.90	2.82	2.62	2.11	-1.26105134662733	1.31233696521641	5.72755246167245e-06	0.000430885507313577	4:121329311-121381059:-	QRFPR	13;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004983,molecular_function neuropeptide Y receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032870,biological_process cellular response to hormone stimulus;GO:0042277,molecular_function peptide binding;GO:1901652,biological_process response to peptide	NA	pyroglutamylated RFamide peptide receptor [Source:HGNC Symbol%3BAcc:HGNC:15565]
ENSG00000105612	117.32	113.09	119.40	95.05	94.73	99.94	0.284249962724023	6.84966502086249	5.82596968315148e-06	0.00043564916672867	19:12875210-12881468:-	DNASE2	16;GO:0000737,biological_process DNA catabolic process, endonucleolytic;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0004531,molecular_function deoxyribonuclease II activity;GO:0005622,cellular_component intracellular;GO:0005764,cellular_component lysosome;GO:0006259,biological_process DNA metabolic process;GO:0006308,biological_process DNA catabolic process;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0016787,molecular_function hydrolase activity;GO:0030218,biological_process erythrocyte differentiation;GO:0070062,cellular_component extracellular exosome	DNASE2; deoxyribonuclease II [EC:3.1.22.1]; K01158	deoxyribonuclease 2%2C lysosomal [Source:HGNC Symbol%3BAcc:HGNC:2960]
ENSG00000136156	979.03	1067.90	986.31	791.10	882.16	803.85	0.303852784646495	9.64529936903148	6.10699977626313e-06	0.000453929270794935	13:48233157-48270357:+	ITM2B	19;GO:0000139,cellular_component Golgi membrane;GO:0001540,molecular_function beta-amyloid binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007399,biological_process nervous system development;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0031301,cellular_component integral component of organelle membrane;GO:0042985,biological_process negative regulation of amyloid precursor protein biosynthetic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome	NA	integral membrane protein 2B [Source:HGNC Symbol%3BAcc:HGNC:6174]
ENSG00000090661	0.54	0.40	0.37	1.27	1.54	1.43	-1.6439827299689	0.340021064844443	6.26501672261704e-06	0.000462902693915746	19:8206735-8262421:+	CERS4	11;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0031965,cellular_component nuclear membrane;GO:0046513,biological_process ceramide biosynthetic process;GO:0050291,molecular_function sphingosine N-acyltransferase activity	CERS1_2_3_4, LASS1_2_3_4; ceramide synthetase [EC:2.3.1.24]; K04710	ceramide synthase 4 [Source:HGNC Symbol%3BAcc:HGNC:23747]
ENSG00000018189	34.25	30.66	38.07	43.61	43.07	45.55	-0.346036956051676	6.51746086508537	7.00123509045138e-06	0.000514238646022325	4:70704203-70807315:+	RUFY3	23;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007015,biological_process actin filament organization;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030175,cellular_component filopodium;GO:0030335,biological_process positive regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0042995,cellular_component cell projection;GO:0043204,cellular_component perikaryon;GO:0045773,biological_process positive regulation of axon extension;GO:0050771,biological_process negative regulation of axonogenesis;GO:0071437,cellular_component invadopodium;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:2000114,biological_process regulation of establishment of cell polarity	NA	RUN and FYVE domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:30285]
ENSG00000165072	20.08	20.52	19.20	25.83	24.18	24.67	-0.31048745245042	5.53418267438834	7.6620720286168e-06	0.000559466471124825	9:70043580-70226970:+	MAMDC2	4;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane	NA	MAM domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:23673]
ENSG00000106397	54.69	48.56	52.96	42.79	39.22	44.43	0.318166252936188	6.78532422263016	7.81409898560853e-06	0.000566573423033991	7:101205976-101218420:-	PLOD3	33;GO:0001701,biological_process in utero embryonic development;GO:0001886,biological_process endothelial cell morphogenesis;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006493,biological_process protein O-linked glycosylation;GO:0008104,biological_process protein localization;GO:0008475,molecular_function procollagen-lysine 5-dioxygenase activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0017185,biological_process peptidyl-lysine hydroxylation;GO:0021915,biological_process neural tube development;GO:0030199,biological_process collagen fibril organization;GO:0030867,cellular_component rough endoplasmic reticulum membrane;GO:0031012,cellular_component extracellular matrix;GO:0031418,molecular_function L-ascorbic acid binding;GO:0032870,biological_process cellular response to hormone stimulus;GO:0032963,biological_process collagen metabolic process;GO:0033823,molecular_function procollagen glucosyltransferase activity;GO:0042311,biological_process vasodilation;GO:0046872,molecular_function metal ion binding;GO:0046947,biological_process hydroxylysine biosynthetic process;GO:0048730,biological_process epidermis morphogenesis;GO:0050211,molecular_function procollagen galactosyltransferase activity;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060425,biological_process lung morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070831,biological_process basement membrane assembly	PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]; K13646	procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 3 [Source:HGNC Symbol%3BAcc:HGNC:9083]
ENSG00000116741	17.07	15.85	16.63	10.53	10.90	12.44	0.561387881760964	3.15983336177372	7.85069111108083e-06	0.000566573423033991	1:192809038-192812283:+	RGS2	31;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006417,biological_process regulation of translation;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0009968,biological_process negative regulation of signal transduction;GO:0010519,biological_process negative regulation of phospholipase activity;GO:0010614,biological_process negative regulation of cardiac muscle hypertrophy;GO:0016020,cellular_component membrane;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0043005,cellular_component neuron projection;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043951,biological_process negative regulation of cAMP-mediated signaling;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0048487,molecular_function beta-tubulin binding;GO:0050873,biological_process brown fat cell differentiation;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060087,biological_process relaxation of vascular smooth muscle;GO:0060452,biological_process positive regulation of cardiac muscle contraction;GO:0071877,biological_process regulation of adrenergic receptor signaling pathway	NA	regulator of G protein signaling 2 [Source:HGNC Symbol%3BAcc:HGNC:9998]
ENSG00000175745	1.22	1.43	0.75	0.30	0.36	0.28	1.84083803458404	0.0563319622932375	8.26167035403736e-06	0.000592786786732172	5:93583336-93594615:+	NR2F1	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008270,molecular_function zinc ion binding;GO:0010977,biological_process negative regulation of neuron projection development;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044323,molecular_function retinoic acid-responsive element binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	nuclear receptor subfamily 2 group F member 1 [Source:HGNC Symbol%3BAcc:HGNC:7975]
ENSG00000136235	10.91	12.90	11.45	6.51	9.77	7.14	0.598947210138443	4.13437529642714	8.6108554004505e-06	0.000614290506240184	7:23235966-23275108:+	GPNMB	31;GO:0001649,biological_process osteoblast differentiation;GO:0001818,biological_process negative regulation of cytokine production;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008201,molecular_function heparin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030282,biological_process bone mineralization;GO:0030335,biological_process positive regulation of cell migration;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0034103,biological_process regulation of tissue remodeling;GO:0042056,molecular_function chemoattractant activity;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042470,cellular_component melanosome;GO:0045545,molecular_function syndecan binding;GO:0045765,biological_process regulation of angiogenesis;GO:0048018,molecular_function receptor agonist activity;GO:0050868,biological_process negative regulation of T cell activation;GO:0050918,biological_process positive chemotaxis;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:1901215,biological_process negative regulation of neuron death;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	glycoprotein nmb [Source:HGNC Symbol%3BAcc:HGNC:4462]
ENSG00000172725	44.98	49.38	43.62	35.57	38.14	38.16	0.311361191396351	6.04242632612945	9.2085630998763e-06	0.000652299406887405	11:67435509-67443821:-	CORO1B	31;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0016477,biological_process cell migration;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0031252,cellular_component cell leading edge;GO:0031529,biological_process ruffle organization;GO:0034315,biological_process regulation of Arp2/3 complex-mediated actin nucleation;GO:0034316,biological_process negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0035767,biological_process endothelial cell chemotaxis;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0042060,biological_process wound healing;GO:0042802,molecular_function identical protein binding;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0070062,cellular_component extracellular exosome;GO:0071672,biological_process negative regulation of smooth muscle cell chemotaxis;GO:0071933,molecular_function Arp2/3 complex binding;GO:0071944,cellular_component cell periphery;GO:0090135,biological_process actin filament branching;GO:1902463,biological_process protein localization to cell leading edge;GO:2000394,biological_process positive regulation of lamellipodium morphogenesis	NA	coronin 1B [Source:HGNC Symbol%3BAcc:HGNC:2253]
ENSG00000115758	63.32	65.71	68.97	83.91	79.19	81.25	-0.291713679407765	6.67562516344456	9.24874692759069e-06	0.000652299406887405	2:10439967-10448504:-	ODC1	19;GO:0001822,biological_process kidney development;GO:0003824,molecular_function catalytic activity;GO:0004586,molecular_function ornithine decarboxylase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009446,biological_process putrescine biosynthetic process;GO:0009615,biological_process response to virus;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0033387,biological_process putrescine biosynthetic process from ornithine;GO:0042176,biological_process regulation of protein catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	ornithine decarboxylase 1 [Source:HGNC Symbol%3BAcc:HGNC:8109]
ENSG00000120306	54.85	58.13	60.95	46.57	40.14	39.39	0.475525865467866	3.87318036036754	9.32487469559311e-06	0.000653952935572866	5:140174641-140282052:+	CYSTM1	8;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane	NA	cysteine rich transmembrane module containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30239]
ENSG00000072310	95.72	103.72	97.93	83.08	83.60	82.32	0.267413717347521	8.38492319934008	9.59052233722805e-06	0.000663776488473288	17:17810398-17837002:-	SREBF1	72;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000139,cellular_component Golgi membrane;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003062,biological_process regulation of heart rate by chemical signal;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0007568,biological_process aging;GO:0007623,biological_process circadian rhythm;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008610,biological_process lipid biosynthetic process;GO:0009267,biological_process cellular response to starvation;GO:0009749,biological_process response to glucose;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019217,biological_process regulation of fatty acid metabolic process;GO:0019901,molecular_function protein kinase binding;GO:0030324,biological_process lung development;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031647,biological_process regulation of protein stability;GO:0032094,biological_process response to food;GO:0032403,molecular_function protein complex binding;GO:0032526,biological_process response to retinoic acid;GO:0032570,biological_process response to progesterone;GO:0032810,molecular_function sterol response element binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033762,biological_process response to glucagon;GO:0033993,biological_process response to lipid;GO:0042493,biological_process response to drug;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045444,biological_process fat cell differentiation;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045542,biological_process positive regulation of cholesterol biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046983,molecular_function protein dimerization activity;GO:0050796,biological_process regulation of insulin secretion;GO:0051591,biological_process response to cAMP;GO:0070542,biological_process response to fatty acid;GO:0071398,biological_process cellular response to fatty acid;GO:1903146,biological_process regulation of mitophagy;GO:1903214,biological_process regulation of protein targeting to mitochondrion	SREBP1, SREBF1; sterol regulatory element-binding transcription factor 1; K07197	sterol regulatory element binding transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11289]
ENSG00000124006	23.13	22.51	23.23	18.85	19.63	19.03	0.27207562261122	6.94262486379238	9.62830967645555e-06	0.000663776488473288	2:219550728-219571859:-	OBSL1	30;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005859,cellular_component muscle myosin complex;GO:0006941,biological_process striated muscle contraction;GO:0007010,biological_process cytoskeleton organization;GO:0007015,biological_process actin filament organization;GO:0007030,biological_process Golgi organization;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008307,molecular_function structural constituent of muscle;GO:0014704,cellular_component intercalated disc;GO:0030018,cellular_component Z disc;GO:0031430,cellular_component M band;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0043687,biological_process post-translational protein modification;GO:0045214,biological_process sarcomere organization;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0051015,molecular_function actin filament binding;GO:0051371,molecular_function muscle alpha-actinin binding;GO:0055003,biological_process cardiac myofibril assembly;GO:0071688,biological_process striated muscle myosin thick filament assembly;GO:0097493,molecular_function structural molecule activity conferring elasticity;GO:1990393,cellular_component 3M complex	NA	obscurin like 1 [Source:HGNC Symbol%3BAcc:HGNC:29092]
ENSG00000139220	0.76	1.28	0.90	0.43	0.30	0.56	1.16527048104894	1.54031560211571	9.63835736430563e-06	0.000663776488473288	12:81257974-81759553:-	PPFIA2	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007160,biological_process cell-matrix adhesion;GO:0007269,biological_process neurotransmitter secretion;GO:0009986,cellular_component cell surface;GO:0014047,biological_process glutamate secretion;GO:0045202,cellular_component synapse;GO:0048786,cellular_component presynaptic active zone;GO:0070062,cellular_component extracellular exosome	NA	PTPRF interacting protein alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:9246]
ENSG00000109501	5.56	7.10	5.60	3.35	4.51	4.24	0.596401040548948	3.77736756692962	9.72293186794169e-06	0.000663776488473288	4:6269848-6303265:+	WFS1	45;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000502,cellular_component proteasome complex;GO:0001822,biological_process kidney development;GO:0003091,biological_process renal water homeostasis;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006983,biological_process ER overload response;GO:0007601,biological_process visual perception;GO:0007605,biological_process sensory perception of sound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022417,biological_process protein maturation by protein folding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030425,cellular_component dendrite;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031016,biological_process pancreas development;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0033613,molecular_function activating transcription factor binding;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042048,biological_process olfactory behavior;GO:0042593,biological_process glucose homeostasis;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045762,biological_process positive regulation of adenylate cyclase activity;GO:0045927,biological_process positive regulation of growth;GO:0048306,molecular_function calcium-dependent protein binding;GO:0050821,biological_process protein stabilization;GO:0050877,biological_process neurological system process;GO:0051117,molecular_function ATPase binding;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0055074,biological_process calcium ion homeostasis;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903892,biological_process negative regulation of ATF6-mediated unfolded protein response;GO:2000675,biological_process negative regulation of type B pancreatic cell apoptotic process	WFS1; wolfamin; K14020	wolframin ER transmembrane glycoprotein [Source:HGNC Symbol%3BAcc:HGNC:12762]
ENSG00000104833	0.92	0.71	0.55	1.62	1.78	1.65	-1.19234273354431	1.08819410246513	9.73232263772967e-06	0.000663776488473288	19:6494318-6502848:-	TUBB4A	24;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0033269,cellular_component internode region of axon;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043209,cellular_component myelin sheath;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	TUBB; tubulin beta; K07375	tubulin beta 4A class IVa [Source:HGNC Symbol%3BAcc:HGNC:20774]
ENSG00000105825	463.83	365.05	466.66	347.17	278.52	337.43	0.440015200585053	8.05480326296528	9.99837728830876e-06	0.000678195941419545	7:93885396-93890991:-	TFPI2	11;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031012,cellular_component extracellular matrix;GO:0071498,biological_process cellular response to fluid shear stress	NA	tissue factor pathway inhibitor 2 [Source:HGNC Symbol%3BAcc:HGNC:11761]
ENSG00000198056	12.46	11.17	11.14	16.09	14.51	17.15	-0.443531053548219	4.15207862508834	1.03244346711829e-05	0.000693686232679707	12:56731595-56752373:-	PRIM1	14;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003697,molecular_function single-stranded DNA binding;GO:0003896,molecular_function DNA primase activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005654,cellular_component nucleoplasm;GO:0005658,cellular_component alpha DNA polymerase:primase complex;GO:0006260,biological_process DNA replication;GO:0006269,biological_process DNA replication, synthesis of RNA primer;GO:0006270,biological_process DNA replication initiation;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0046872,molecular_function metal ion binding	PRI1; DNA primase small subunit [EC:2.7.7.102]; K02684	primase (DNA) subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:9369]
ENSG00000197982	67.42	75.58	65.57	49.46	55.16	52.42	0.414561630121598	4.33407533144715	1.03385122891924e-05	0.000693686232679707	1:37806978-37809454:+	C1orf122	NA	NA	chromosome 1 open reading frame 122 [Source:HGNC Symbol%3BAcc:HGNC:24789]
ENSG00000276043	12.41	13.93	12.74	16.70	16.10	16.44	-0.327164546222139	5.26527664236217	1.04922481580398e-05	0.000700216539708324	19:4903079-4962154:+	UHRF1	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000791,cellular_component euchromatin;GO:0000792,cellular_component heterochromatin;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005657,cellular_component replication fork;GO:0005720,cellular_component nuclear heterochromatin;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008327,molecular_function methyl-CpG binding;GO:0010216,biological_process maintenance of DNA methylation;GO:0010390,biological_process histone monoubiquitination;GO:0016363,cellular_component nuclear matrix;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016574,biological_process histone ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031493,molecular_function nucleosomal histone binding;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0035064,molecular_function methylated histone binding;GO:0042393,molecular_function histone binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0044729,molecular_function hemi-methylated DNA-binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0090308,biological_process regulation of methylation-dependent chromatin silencing;GO:2000373,biological_process positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	NA	ubiquitin like with PHD and ring finger domains 1 [Source:HGNC Symbol%3BAcc:HGNC:12556]
ENSG00000150630	18.54	18.17	18.33	14.12	10.62	14.77	0.488332306706497	4.31691184060876	1.12034753158869e-05	0.000743683096770611	4:176683537-176792727:-	VEGFC	38;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006929,biological_process substrate-dependent cell migration;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0030154,biological_process cell differentiation;GO:0030947,biological_process regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0042056,molecular_function chemoattractant activity;GO:0042493,biological_process response to drug;GO:0043185,molecular_function vascular endothelial growth factor receptor 3 binding;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045776,biological_process negative regulation of blood pressure;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050714,biological_process positive regulation of protein secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050918,biological_process positive chemotaxis;GO:0050930,biological_process induction of positive chemotaxis;GO:0051781,biological_process positive regulation of cell division;GO:0060754,biological_process positive regulation of mast cell chemotaxis;GO:1901492,biological_process positive regulation of lymphangiogenesis;GO:1990830,biological_process cellular response to leukemia inhibitory factor	VEGFC_D; vascular endothelial growth factor C/D; K05449	vascular endothelial growth factor C [Source:HGNC Symbol%3BAcc:HGNC:12682]
ENSG00000113645	35.08	36.01	35.33	42.05	43.95	43.15	-0.267975950325174	7.04631736032584	1.1911164552462e-05	0.000786453646753781	5:168291650-168472303:+	WWC1	25;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0019900,molecular_function kinase binding;GO:0030010,biological_process establishment of cell polarity;GO:0030674,molecular_function protein binding, bridging;GO:0032386,biological_process regulation of intracellular transport;GO:0032587,cellular_component ruffle membrane;GO:0032947,molecular_function protein complex scaffold;GO:0035329,biological_process hippo signaling;GO:0035330,biological_process regulation of hippo signaling;GO:0035331,biological_process negative regulation of hippo signaling;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0046621,biological_process negative regulation of organ growth;GO:0048471,cellular_component perinuclear region of cytoplasm	WWC1; protein KIBRA; K16685	WW and C2 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29435]
ENSG00000137673	187.63	205.57	187.26	134.69	171.00	148.01	0.366580245221846	7.11042123651051	1.21463509383702e-05	0.00079773891110047	11:102520507-102530753:-	MMP7	23;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0007568,biological_process aging;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009986,cellular_component cell surface;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0031667,biological_process response to nutrient levels;GO:0044849,biological_process estrous cycle;GO:0046872,molecular_function metal ion binding;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0070062,cellular_component extracellular exosome;GO:0071260,biological_process cellular response to mechanical stimulus	MMP7; matrix metalloproteinase-7 (matrilysin, uterine) [EC:3.4.24.23]; K01397	matrix metallopeptidase 7 [Source:HGNC Symbol%3BAcc:HGNC:7174]
ENSG00000169288	32.86	33.42	28.15	42.26	37.77	43.43	-0.378810966441429	5.15886815317434	1.30301232623179e-05	0.000851278526606061	4:77862519-77952790:+	MRPL1	17;GO:0000469,biological_process cleavage involved in rRNA processing;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015934,cellular_component large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031118,biological_process rRNA pseudouridine synthesis;GO:0031120,biological_process snRNA pseudouridine synthesis;GO:0031429,cellular_component box H/ACA snoRNP complex;GO:0034513,molecular_function box H/ACA snoRNA binding;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L1, MRPL1, rplA; large subunit ribosomal protein L1; K02863	mitochondrial ribosomal protein L1 [Source:HGNC Symbol%3BAcc:HGNC:14275]
ENSG00000213699	55.90	49.71	54.03	68.62	64.60	64.88	-0.296138185606048	6.05865025157387	1.32250284000165e-05	0.000859488364028299	2:26764283-26781231:+	SLC35F6	13;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome;GO:1901029,biological_process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	NA	solute carrier family 35 member F6 [Source:HGNC Symbol%3BAcc:HGNC:26055]
ENSG00000174197	4.74	4.74	4.54	3.69	3.74	4.00	0.304180740843829	5.34246517866795	1.36418678064602e-05	0.000878808967258579	15:41621223-41773081:+	MGA	8;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046983,molecular_function protein dimerization activity;GO:0071339,cellular_component MLL1 complex	NA	MGA%2C MAX dimerization protein [Source:HGNC Symbol%3BAcc:HGNC:14010]
ENSG00000123989	25.03	27.06	24.82	20.08	21.47	21.39	0.297670532385548	5.76593184144253	1.36639112769601e-05	0.000878808967258579	2:219538946-219543787:-	CHPF	16;GO:0000139,cellular_component Golgi membrane;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0047238,molecular_function glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0050510,molecular_function N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHPF; chondroitin polymerizing factor [EC:2.4.1.175 2.4.1.226]; K00747	chondroitin polymerizing factor [Source:HGNC Symbol%3BAcc:HGNC:24291]
ENSG00000160216	40.01	41.51	38.43	47.72	50.70	49.75	-0.295402644467525	5.66143987755619	1.42230662210288e-05	0.000910056293822837	21:43865185-43986536:+	AGPAT3	17;GO:0000139,cellular_component Golgi membrane;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0042171,molecular_function lysophosphatidic acid acyltransferase activity	AGPAT3_4; lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]; K13523	1-acylglycerol-3-phosphate O-acyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:326]
ENSG00000120885	283.57	281.41	299.96	229.84	253.59	237.29	0.27515677717248	8.5238343967338	1.43869822840843e-05	0.000912539214718714	8:27596916-27615031:-	CLU	80;GO:0000902,biological_process cell morphogenesis;GO:0001540,molecular_function beta-amyloid binding;GO:0001774,biological_process microglial cell activation;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0002376,biological_process immune system process;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006915,biological_process apoptotic process;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0009615,biological_process response to virus;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0017038,biological_process protein import;GO:0019730,biological_process antimicrobial humoral response;GO:0030449,biological_process regulation of complement activation;GO:0031012,cellular_component extracellular matrix;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032286,biological_process central nervous system myelin maintenance;GO:0032403,molecular_function protein complex binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032463,biological_process negative regulation of protein homooligomerization;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0034366,cellular_component spherical high-density lipoprotein particle;GO:0042583,cellular_component chromaffin granule;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043691,biological_process reverse cholesterol transport;GO:0045087,biological_process innate immune response;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0050821,biological_process protein stabilization;GO:0051087,molecular_function chaperone binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051787,molecular_function misfolded protein binding;GO:0051788,biological_process response to misfolded protein;GO:0060548,biological_process negative regulation of cell death;GO:0061077,biological_process chaperone-mediated protein folding;GO:0061518,biological_process microglial cell proliferation;GO:0061740,biological_process protein targeting to lysosome involved in chaperone-mediated autophagy;GO:0061741,biological_process chaperone-mediated protein transport involved in chaperone-mediated autophagy;GO:0070062,cellular_component extracellular exosome;GO:0071944,cellular_component cell periphery;GO:0072562,cellular_component blood microparticle;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097418,cellular_component neurofibrillary tangle;GO:0097440,cellular_component apical dendrite;GO:1900221,biological_process regulation of beta-amyloid clearance;GO:1901214,biological_process regulation of neuron death;GO:1901216,biological_process positive regulation of neuron death;GO:1902004,biological_process positive regulation of beta-amyloid formation;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1902430,biological_process negative regulation of beta-amyloid formation;GO:1902847,biological_process regulation of neuronal signal transduction;GO:1902949,biological_process positive regulation of tau-protein kinase activity;GO:1902998,biological_process positive regulation of neurofibrillary tangle assembly;GO:1903573,biological_process negative regulation of response to endoplasmic reticulum stress;GO:1905892,biological_process negative regulation of cellular response to thapsigargin;GO:1905895,biological_process negative regulation of cellular response to tunicamycin;GO:1905907,biological_process negative regulation of amyloid fibril formation;GO:1905908,biological_process positive regulation of amyloid fibril formation;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	CLU; clusterin; K17252	clusterin [Source:HGNC Symbol%3BAcc:HGNC:2095]
ENSG00000125730	48.10	51.35	50.70	34.41	45.09	35.78	0.392880946649657	7.79905396567036	1.44089008366123e-05	0.000912539214718714	19:6677703-6730562:-	C3	45;GO:0001798,biological_process positive regulation of type IIa hypersensitivity;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001970,biological_process positive regulation of activation of membrane attack complex;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006911,biological_process phagocytosis, engulfment;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0006956,biological_process complement activation;GO:0006957,biological_process complement activation, alternative pathway;GO:0006958,biological_process complement activation, classical pathway;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010828,biological_process positive regulation of glucose transport;GO:0010866,biological_process regulation of triglyceride biosynthetic process;GO:0010884,biological_process positive regulation of lipid storage;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030449,biological_process regulation of complement activation;GO:0031715,molecular_function C5L2 anaphylatoxin chemotactic receptor binding;GO:0034774,cellular_component secretory granule lumen;GO:0035578,cellular_component azurophil granule lumen;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045087,biological_process innate immune response;GO:0045745,biological_process positive regulation of G-protein coupled receptor protein signaling pathway;GO:0045766,biological_process positive regulation of angiogenesis;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050776,biological_process regulation of immune response;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle;GO:0097242,biological_process beta-amyloid clearance;GO:2000427,biological_process positive regulation of apoptotic cell clearance	C3; complement component 3; K03990	complement C3 [Source:HGNC Symbol%3BAcc:HGNC:1318]
ENSG00000064601	317.56	329.29	337.75	267.21	290.43	255.04	0.288558039538696	8.81429019693186	1.53755707537763e-05	0.000968817054652919	20:45890143-45898820:+	CTSA	26;GO:0004180,molecular_function carboxypeptidase activity;GO:0004185,molecular_function serine-type carboxypeptidase activity;GO:0004308,molecular_function exo-alpha-sialidase activity;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0006508,biological_process proteolysis;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006886,biological_process intracellular protein transport;GO:0008047,molecular_function enzyme activator activity;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031647,biological_process regulation of protein stability;GO:0035578,cellular_component azurophil granule lumen;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0098575,cellular_component lumenal side of lysosomal membrane;GO:1904714,biological_process regulation of chaperone-mediated autophagy;GO:1904715,biological_process negative regulation of chaperone-mediated autophagy	CTSA, CPY; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]; K13289	cathepsin A [Source:HGNC Symbol%3BAcc:HGNC:9251]
ENSG00000160867	25.02	25.39	24.06	19.28	21.99	19.15	0.313255918562982	5.85122532511767	1.58113616406578e-05	0.000989668078971083	5:177086885-177098144:+	FGFR4	50;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005007,molecular_function fibroblast growth factor-activated receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006468,biological_process protein phosphorylation;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010628,biological_process positive regulation of gene expression;GO:0010715,biological_process regulation of extracellular matrix disassembly;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0017134,molecular_function fibroblast growth factor binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030133,cellular_component transport vesicle;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042593,biological_process glucose homeostasis;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045862,biological_process positive regulation of proteolysis;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0055062,biological_process phosphate ion homeostasis;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070857,biological_process regulation of bile acid biosynthetic process;GO:2000188,biological_process regulation of cholesterol homeostasis;GO:2000573,biological_process positive regulation of DNA biosynthetic process	FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]; K05095	fibroblast growth factor receptor 4 [Source:HGNC Symbol%3BAcc:HGNC:3691]
ENSG00000160781	19.79	17.20	19.71	15.48	14.26	14.58	0.37300608263833	4.7662493501904	1.58659427789612e-05	0.000989668078971083	1:156243320-156248117:-	PAQR6	7;GO:0003707,molecular_function steroid hormone receptor activity;GO:0005496,molecular_function steroid binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0048545,biological_process response to steroid hormone	NA	progestin and adipoQ receptor family member 6 [Source:HGNC Symbol%3BAcc:HGNC:30132]
ENSG00000013288	21.89	21.41	20.39	17.26	17.46	18.18	0.278795699142216	5.90443832742394	1.64443650152586e-05	0.00102061951467202	4:6575174-6623362:+	MAN2B2	16;GO:0003824,molecular_function catalytic activity;GO:0004559,molecular_function alpha-mannosidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005975,biological_process carbohydrate metabolic process;GO:0006013,biological_process mannose metabolic process;GO:0006517,biological_process protein deglycosylation;GO:0008152,biological_process metabolic process;GO:0008496,molecular_function mannan endo-1,6-alpha-mannosidase activity;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030246,molecular_function carbohydrate binding;GO:0043202,cellular_component lysosomal lumen;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	MAN2B2; epididymis-specific alpha-mannosidase [EC:3.2.1.24]; K12312	mannosidase alpha class 2B member 2 [Source:HGNC Symbol%3BAcc:HGNC:29623]
ENSG00000179750	25.13	25.29	23.28	31.32	29.77	30.66	-0.306393443234795	5.34863536575144	1.66928707871672e-05	0.00103088858249307	22:38982346-38992804:+	APOBEC3B	12;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005634,cellular_component nucleus;GO:0008270,molecular_function zinc ion binding;GO:0010529,biological_process negative regulation of transposition;GO:0016787,molecular_function hydrolase activity;GO:0016814,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0047844,molecular_function deoxycytidine deaminase activity;GO:0051607,biological_process defense response to virus	NA	apolipoprotein B mRNA editing enzyme catalytic subunit 3B [Source:HGNC Symbol%3BAcc:HGNC:17352]
ENSG00000082014	31.43	31.83	32.46	24.25	23.87	28.38	0.333861094613985	5.45085050919902	1.68312847265046e-05	0.00103429077876288	7:151238763-151277896:-	SMARCD3	30;GO:0000790,cellular_component nuclear chromatin;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0003007,biological_process heart morphogenesis;GO:0003139,biological_process secondary heart field specification;GO:0003219,biological_process cardiac right ventricle formation;GO:0003407,biological_process neural retina development;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005102,molecular_function receptor binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0019216,biological_process regulation of lipid metabolic process;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0042692,biological_process muscle cell differentiation;GO:0043393,biological_process regulation of protein binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051152,biological_process positive regulation of smooth muscle cell differentiation;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:0090544,cellular_component BAF-type complex	SMARCD; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D; K11650	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily d%2C member 3 [Source:HGNC Symbol%3BAcc:HGNC:11108]
ENSG00000012779	0.56	0.19	0.36	1.18	0.67	1.49	-1.52437225784951	0.771335177489754	1.73127027930227e-05	0.00105863339788074	10:45374175-45446119:+	ALOX5	28;GO:0002540,biological_process leukotriene production involved in inflammatory response;GO:0004051,molecular_function arachidonate 5-lipoxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005641,cellular_component nuclear envelope lumen;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006691,biological_process leukotriene metabolic process;GO:0006954,biological_process inflammatory response;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0019370,biological_process leukotriene biosynthetic process;GO:0019372,biological_process lipoxygenase pathway;GO:0031965,cellular_component nuclear membrane;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2001300,biological_process lipoxin metabolic process	ALOX5; arachidonate 5-lipoxygenase [EC:1.13.11.34]; K00461	arachidonate 5-lipoxygenase [Source:HGNC Symbol%3BAcc:HGNC:435]
ENSG00000213341	13.68	13.81	15.18	17.62	17.68	18.37	-0.317862095509	5.17515570460945	1.75971737118153e-05	0.00107075351610178	10:100188297-100229619:-	CHUK	59;GO:0000166,molecular_function nucleotide binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003009,biological_process skeletal muscle contraction;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007252,biological_process I-kappaB phosphorylation;GO:0007266,biological_process Rho protein signal transduction;GO:0008384,molecular_function IkappaB kinase activity;GO:0008385,cellular_component IkappaB kinase complex;GO:0009615,biological_process response to virus;GO:0009636,biological_process response to toxic substance;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010033,biological_process response to organic substance;GO:0010034,biological_process response to acetate;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0033194,biological_process response to hydroperoxide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035631,cellular_component CD40 receptor complex;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043200,biological_process response to amino acid;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045087,biological_process innate immune response;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051146,biological_process striated muscle cell differentiation;GO:0051403,biological_process stress-activated MAPK cascade;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0071276,biological_process cellular response to cadmium ion;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0097110,molecular_function scaffold protein binding;GO:0098586,biological_process cellular response to virus;GO:1902741,biological_process positive regulation of interferon-alpha secretion	IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]; K04467	conserved helix-loop-helix ubiquitous kinase [Source:HGNC Symbol%3BAcc:HGNC:1974]
ENSG00000008394	1021.07	1091.91	1049.22	899.35	893.14	883.22	0.252517499373869	8.94219642168886	1.79674202611957e-05	0.00108794920830352	12:16347141-16609259:+	MGST1	30;GO:0004364,molecular_function glutathione transferase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006805,biological_process xenobiotic metabolic process;GO:0010243,biological_process response to organonitrogen compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0033327,biological_process Leydig cell differentiation;GO:0035577,cellular_component azurophil granule membrane;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043295,molecular_function glutathione binding;GO:0043312,biological_process neutrophil degranulation;GO:0045177,cellular_component apical part of cell;GO:0055114,biological_process oxidation-reduction process;GO:0070207,biological_process protein homotrimerization;GO:0071449,biological_process cellular response to lipid hydroperoxide;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	microsomal glutathione S-transferase 1 [Source:HGNC Symbol%3BAcc:HGNC:7061]
ENSG00000206530	3.95	3.52	3.29	2.53	2.73	2.78	0.433588306912377	4.14809290703601	1.92302475831852e-05	0.00115498033208219	3:113286946-113441610:-	CFAP44	2;GO:0042995,cellular_component cell projection;GO:0060285,biological_process cilium-dependent cell motility	NA	cilia and flagella associated protein 44 [Source:HGNC Symbol%3BAcc:HGNC:25631]
ENSG00000122644	77.10	74.54	76.42	63.14	63.45	61.76	0.28929686288932	5.38495303711775	1.92605275711765e-05	0.00115498033208219	7:12686855-12690934:+	ARL4A	13;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0050873,biological_process brown fat cell differentiation	NA	ADP ribosylation factor like GTPase 4A [Source:HGNC Symbol%3BAcc:HGNC:695]
ENSG00000183778	13.50	16.84	16.02	11.52	10.55	10.60	0.508430902919733	3.6405934760137	2.02130129439628e-05	0.00120626985419909	21:39556441-39673137:+	B3GALT5	10;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0008499,molecular_function UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	B3GALT5; beta-1,3-galactosyltransferase 5 [EC:2.4.1.-]; K03877	beta-1%2C3-galactosyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:920]
ENSG00000196937	247.55	267.33	233.34	190.20	216.17	201.87	0.30957642293156	7.26770868295194	2.05606578588747e-05	0.00122114567465173	7:121348850-121396364:-	FAM3C	10;GO:0002576,biological_process platelet degranulation;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process;GO:0031089,cellular_component platelet dense granule lumen;GO:0031410,cellular_component cytoplasmic vesicle;GO:0070062,cellular_component extracellular exosome	NA	family with sequence similarity 3 member C [Source:HGNC Symbol%3BAcc:HGNC:18664]
ENSG00000112294	5.71	5.87	5.24	7.51	7.98	8.21	-0.487918896611579	3.49780000078961	2.10381638932201e-05	0.00124355584955496	6:24494851-24537207:+	ALDH5A1	27;GO:0004777,molecular_function succinate-semialdehyde dehydrogenase (NAD+) activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006006,biological_process glucose metabolic process;GO:0006083,biological_process acetate metabolic process;GO:0006105,biological_process succinate metabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006540,biological_process glutamate decarboxylation to succinate;GO:0006541,biological_process glutamine metabolic process;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0006678,biological_process glucosylceramide metabolic process;GO:0006681,biological_process galactosylceramide metabolic process;GO:0006749,biological_process glutathione metabolic process;GO:0007417,biological_process central nervous system development;GO:0008152,biological_process metabolic process;GO:0009013,molecular_function succinate-semialdehyde dehydrogenase [NAD(P)+] activity;GO:0009448,biological_process gamma-aminobutyric acid metabolic process;GO:0009450,biological_process gamma-aminobutyric acid catabolic process;GO:0009791,biological_process post-embryonic development;GO:0016491,molecular_function oxidoreductase activity;GO:0022904,biological_process respiratory electron transport chain;GO:0042135,biological_process neurotransmitter catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0046459,biological_process short-chain fatty acid metabolic process;GO:0051287,molecular_function NAD binding;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process	ALDH5A1; succinate-semialdehyde dehydrogenase [EC:1.2.1.24]; K00139	aldehyde dehydrogenase 5 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:408]
ENSG00000123080	118.55	120.78	110.69	84.83	103.53	89.99	0.341512227057188	5.72450399525307	2.11629057818738e-05	0.00124500070839052	1:50960744-50974633:+	CDKN2C	17;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030308,biological_process negative regulation of cell growth;GO:0042326,biological_process negative regulation of phosphorylation;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0048709,biological_process oligodendrocyte differentiation	CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C; K06622	cyclin dependent kinase inhibitor 2C [Source:HGNC Symbol%3BAcc:HGNC:1789]
ENSG00000138670	1.63	1.44	1.49	2.62	2.36	2.72	-0.734075000665081	2.17881571724209	2.19748983811776e-05	0.00128667176229037	4:81426392-82044244:-	RASGEF1B	9;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0030496,cellular_component midbody;GO:0043547,biological_process positive regulation of GTPase activity	NA	RasGEF domain family member 1B [Source:HGNC Symbol%3BAcc:HGNC:24881]
ENSG00000155850	3.47	4.01	3.62	5.40	5.34	5.14	-0.512971699567715	3.34208518471857	2.23022501875637e-05	0.00129970812947525	5:149960736-149993455:+	SLC26A2	23;GO:0001503,biological_process ossification;GO:0005254,molecular_function chloride channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008271,molecular_function secondary active sulfate transmembrane transporter activity;GO:0008272,biological_process sulfate transport;GO:0015106,molecular_function bicarbonate transmembrane transporter activity;GO:0015116,molecular_function sulfate transmembrane transporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019531,molecular_function oxalate transmembrane transporter activity;GO:0019532,biological_process oxalate transport;GO:0042391,biological_process regulation of membrane potential;GO:0050428,biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1902358,biological_process sulfate transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 26 member 2 [Source:HGNC Symbol%3BAcc:HGNC:10994]
ENSG00000115657	16.82	16.71	17.44	14.24	14.00	13.70	0.294131266390442	5.30276333847735	2.30822684756655e-05	0.00133887943265624	2:219209767-219218990:-	ABCB6	32;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006810,biological_process transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007420,biological_process brain development;GO:0010008,cellular_component endosome membrane;GO:0015232,molecular_function heme transporter activity;GO:0015439,molecular_function heme-transporting ATPase activity;GO:0015562,molecular_function efflux transmembrane transporter activity;GO:0015886,biological_process heme transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0020037,molecular_function heme binding;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043190,cellular_component ATP-binding cassette (ABC) transporter complex;GO:0043588,biological_process skin development;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	ABCB6; ATP-binding cassette, subfamily B (MDR/TAP), member 6; K05661	ATP binding cassette subfamily B member 6 (Langereis blood group) [Source:HGNC Symbol%3BAcc:HGNC:47]
ENSG00000147100	31.37	31.53	31.93	26.79	25.11	26.74	0.281041007414309	5.57670848344753	2.34653713252322e-05	0.00135477048493073	X:74421460-74533917:+	SLC16A2	13;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015349,molecular_function thyroid hormone transmembrane transporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043252,biological_process sodium-independent organic anion transport;GO:0055085,biological_process transmembrane transport;GO:0070327,biological_process thyroid hormone transport	SLC16A2; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 2; K08231	solute carrier family 16 member 2 [Source:HGNC Symbol%3BAcc:HGNC:10923]
ENSG00000068489	30.36	31.12	27.36	35.84	39.22	37.02	-0.326050751134658	5.29924723057736	2.36895588417614e-05	0.00136138191621659	17:59155498-59204705:+	PRR11	5;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007050,biological_process cell cycle arrest;GO:0016020,cellular_component membrane;GO:0051726,biological_process regulation of cell cycle	NA	proline rich 11 [Source:HGNC Symbol%3BAcc:HGNC:25619]
ENSG00000117399	87.19	82.54	82.30	99.73	111.56	99.30	-0.289019836441787	7.13605533264872	2.4258931359008e-05	0.00138767794912151	1:43358954-43363203:+	CDC20	38;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0007399,biological_process nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010997,molecular_function anaphase-promoting complex binding;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031915,biological_process positive regulation of synaptic plasticity;GO:0040020,biological_process regulation of meiotic nuclear division;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042826,molecular_function histone deacetylase binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050773,biological_process regulation of dendrite development;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0090129,biological_process positive regulation of synapse maturation;GO:0090307,biological_process mitotic spindle assembly;GO:0097027,molecular_function ubiquitin-protein transferase activator activity;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	CDC20; cell division cycle 20, cofactor of APC complex; K03363	cell division cycle 20 [Source:HGNC Symbol%3BAcc:HGNC:1723]
ENSG00000204642	26.37	24.09	24.08	20.85	17.47	20.34	0.358357593699687	5.04079040906631	2.43908508711822e-05	0.00138882399937608	6:29722774-29738528:+	HLA-F	23;GO:0000139,cellular_component Golgi membrane;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0005102,molecular_function receptor binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031901,cellular_component early endosome membrane;GO:0042605,molecular_function peptide antigen binding;GO:0042612,cellular_component MHC class I protein complex;GO:0046978,molecular_function TAP1 binding;GO:0046979,molecular_function TAP2 binding;GO:0050776,biological_process regulation of immune response;GO:0055038,cellular_component recycling endosome membrane;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane	MHC1; MHC class I antigen; K06751	major histocompatibility complex%2C class I%2C F [Source:HGNC Symbol%3BAcc:HGNC:4963]
ENSG00000118785	5860.14	6682.79	6234.30	4532.93	5586.34	4747.82	0.348738090378507	12.3686999447045	2.49796776296625e-05	0.00140915297644338	4:87975649-87983426:+	SPP1	32;GO:0001503,biological_process ossification;GO:0001649,biological_process osteoblast differentiation;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0006710,biological_process androgen catabolic process;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007566,biological_process embryo implantation;GO:0010033,biological_process response to organic substance;GO:0022617,biological_process extracellular matrix disassembly;GO:0030154,biological_process cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0031214,biological_process biomineral tissue development;GO:0031982,cellular_component vesicle;GO:0033280,biological_process response to vitamin D;GO:0042995,cellular_component cell projection;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045780,biological_process positive regulation of bone resorption;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046697,biological_process decidualization;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048545,biological_process response to steroid hormone;GO:0048685,biological_process negative regulation of collateral sprouting of intact axon in response to injury;GO:0050840,molecular_function extracellular matrix binding;GO:0070062,cellular_component extracellular exosome;GO:0071394,biological_process cellular response to testosterone stimulus;GO:2000866,biological_process positive regulation of estradiol secretion	SPP1, BNSP, OPN; secreted phosphoprotein 1; K06250	secreted phosphoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:11255]
ENSG00000138642	5.49	5.55	5.17	7.24	7.11	6.85	-0.377499509939723	4.28792391285042	2.50449364044173e-05	0.00140915297644338	4:88378738-88443111:+	HERC6	9;GO:0000209,biological_process protein polyubiquitination;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [Source:HGNC Symbol%3BAcc:HGNC:26072]
ENSG00000030582	452.91	469.22	469.67	377.99	412.12	384.73	0.256248202891464	9.66752967930029	2.51729032616026e-05	0.00140915297644338	17:44345085-44353102:+	GRN	13;GO:0003723,molecular_function RNA binding;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0007165,biological_process signal transduction;GO:0008083,molecular_function growth factor activity;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	granulin precursor [Source:HGNC Symbol%3BAcc:HGNC:4601]
ENSG00000197653	0.82	0.91	0.93	0.64	0.63	0.62	0.495702940285275	3.42508760933205	2.5201962520779e-05	0.00140915297644338	12:123762187-123936206:+	DNAH10	19;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007018,biological_process microtubule-based movement;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0030286,cellular_component dynein complex;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding	NA	dynein axonemal heavy chain 10 [Source:HGNC Symbol%3BAcc:HGNC:2941]
ENSG00000196139	276.02	312.47	271.80	206.04	255.58	210.30	0.367904966246678	8.09261520498519	2.58302454173272e-05	0.00143780644109992	10:5035353-5107686:+	AKR1C3	62;GO:0000060,biological_process protein import into nucleus, translocation;GO:0001523,biological_process retinoid metabolic process;GO:0001758,molecular_function retinal dehydrogenase activity;GO:0004032,molecular_function alditol:NADP+ 1-oxidoreductase activity;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0004745,molecular_function retinol dehydrogenase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006693,biological_process prostaglandin metabolic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007584,biological_process response to nutrient;GO:0008202,biological_process steroid metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0009267,biological_process cellular response to starvation;GO:0010942,biological_process positive regulation of cell death;GO:0016488,biological_process farnesol catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016655,molecular_function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636,molecular_function phenanthrene 9,10-monooxygenase activity;GO:0019371,biological_process cyclooxygenase pathway;GO:0030216,biological_process keratinocyte differentiation;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035410,molecular_function dihydrotestosterone 17-beta-dehydrogenase activity;GO:0036130,molecular_function prostaglandin H2 endoperoxidase reductase activity;GO:0036131,molecular_function prostaglandin D2 11-ketoreductase activity;GO:0042448,biological_process progesterone metabolic process;GO:0042572,biological_process retinol metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0044259,biological_process multicellular organismal macromolecule metabolic process;GO:0044597,biological_process daunorubicin metabolic process;GO:0044598,biological_process doxorubicin metabolic process;GO:0045550,molecular_function geranylgeranyl reductase activity;GO:0045703,molecular_function ketoreductase activity;GO:0047017,molecular_function prostaglandin-F synthase activity;GO:0047020,molecular_function 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0047023,molecular_function androsterone dehydrogenase activity;GO:0047035,molecular_function testosterone dehydrogenase (NAD+) activity;GO:0047045,molecular_function testosterone 17-beta-dehydrogenase (NADP+) activity;GO:0047086,molecular_function ketosteroid monooxygenase activity;GO:0047115,molecular_function trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0047718,molecular_function indanol dehydrogenase activity;GO:0047787,molecular_function delta4-3-oxosteroid 5beta-reductase activity;GO:0048385,biological_process regulation of retinoic acid receptor signaling pathway;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0052650,molecular_function NADP-retinol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0061370,biological_process testosterone biosynthetic process;GO:0070062,cellular_component extracellular exosome;GO:0070293,biological_process renal absorption;GO:0071276,biological_process cellular response to cadmium ion;GO:0071277,biological_process cellular response to calcium ion;GO:0071379,biological_process cellular response to prostaglandin stimulus;GO:0071384,biological_process cellular response to corticosteroid stimulus;GO:0071395,biological_process cellular response to jasmonic acid stimulus;GO:0071799,biological_process cellular response to prostaglandin D stimulus;GO:1900053,biological_process negative regulation of retinoic acid biosynthetic process;GO:2000224,biological_process regulation of testosterone biosynthetic process;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	AKR1C3; aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]; K04119	aldo-keto reductase family 1 member C3 [Source:HGNC Symbol%3BAcc:HGNC:386]
ENSG00000150540	8.70	8.67	7.63	5.82	4.07	6.06	0.653230352895419	2.90395968520396	2.77477985022083e-05	0.00153764920896389	2:137964019-138016364:+	HNMT	21;GO:0001695,biological_process histamine catabolic process;GO:0002347,biological_process response to tumor cell;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006548,biological_process histidine catabolic process;GO:0006972,biological_process hyperosmotic response;GO:0007420,biological_process brain development;GO:0007585,biological_process respiratory gaseous exchange;GO:0008168,molecular_function methyltransferase activity;GO:0008170,molecular_function N-methyltransferase activity;GO:0014075,biological_process response to amine;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0035902,biological_process response to immobilization stress;GO:0042220,biological_process response to cocaine;GO:0043005,cellular_component neuron projection;GO:0046539,molecular_function histamine N-methyltransferase activity;GO:0051384,biological_process response to glucocorticoid;GO:0070062,cellular_component extracellular exosome;GO:0070555,biological_process response to interleukin-1;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	HNMT; histamine N-methyltransferase [EC:2.1.1.8]; K00546	histamine N-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:5028]
ENSG00000134516	1.01	0.93	1.02	1.40	1.50	1.54	-0.571352465393293	2.84437865498824	2.89808092077588e-05	0.00159883904309294	5:169637246-170083382:+	DOCK2	33;GO:0001766,biological_process membrane raft polarization;GO:0001768,biological_process establishment of T cell polarity;GO:0001771,biological_process immunological synapse formation;GO:0002277,biological_process myeloid dendritic cell activation involved in immune response;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006935,biological_process chemotaxis;GO:0007010,biological_process cytoskeleton organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0035580,cellular_component specific granule lumen;GO:0042098,biological_process T cell proliferation;GO:0042110,biological_process T cell activation;GO:0042608,molecular_function T cell receptor binding;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044351,biological_process macropinocytosis;GO:0045059,biological_process positive thymic T cell selection;GO:0045060,biological_process negative thymic T cell selection;GO:0046631,biological_process alpha-beta T cell activation;GO:0046633,biological_process alpha-beta T cell proliferation;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050766,biological_process positive regulation of phagocytosis;GO:0070062,cellular_component extracellular exosome	DOCK2; dedicator of cytokinesis protein 2; K12367	dedicator of cytokinesis 2 [Source:HGNC Symbol%3BAcc:HGNC:2988]
ENSG00000138821	32.87	33.18	30.03	38.26	43.17	38.85	-0.313653951467067	5.71013660821411	2.92630444064402e-05	0.00160726623989886	4:102251040-102431258:-	SLC39A8	15;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0031090,cellular_component organelle membrane;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0070574,biological_process cadmium ion transmembrane transport;GO:0071578,biological_process zinc II ion transmembrane import	SLC39A8, ZIP8; solute carrier family 39 (zinc transporter), member 8; K14714	solute carrier family 39 member 8 [Source:HGNC Symbol%3BAcc:HGNC:20862]
ENSG00000091409	9.74	9.57	9.39	12.60	11.05	12.45	-0.319437868274896	5.24714815715879	3.0135342226938e-05	0.00164788547604838	2:172427353-172506282:+	ITGA6	52;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005604,cellular_component basement membrane;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0007044,biological_process cell-substrate junction assembly;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0009925,cellular_component basal plasma membrane;GO:0009986,cellular_component cell surface;GO:0010668,biological_process ectodermal cell differentiation;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030056,cellular_component hemidesmosome;GO:0030175,cellular_component filopodium;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0031581,biological_process hemidesmosome assembly;GO:0031589,biological_process cell-substrate adhesion;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0032403,molecular_function protein complex binding;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0034676,cellular_component integrin alpha6-beta4 complex;GO:0035878,biological_process nail development;GO:0038132,molecular_function neuregulin binding;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043236,molecular_function laminin binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043588,biological_process skin development;GO:0045178,cellular_component basal part of cell;GO:0045296,molecular_function cadherin binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046847,biological_process filopodium assembly;GO:0046872,molecular_function metal ion binding;GO:0048565,biological_process digestive tract development;GO:0050873,biological_process brown fat cell differentiation;GO:0050900,biological_process leukocyte migration;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0072001,biological_process renal system development;GO:0097186,biological_process amelogenesis;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	ITGA6, CD49f; integrin alpha 6; K06485	integrin subunit alpha 6 [Source:HGNC Symbol%3BAcc:HGNC:6142]
ENSG00000124762	46.80	49.53	48.62	66.81	60.12	59.31	-0.351606188039227	4.77375416526751	3.03086271163276e-05	0.00165009205436392	6:36676459-36687339:+	CDKN1A	78;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007265,biological_process Ras protein signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009411,biological_process response to UV;GO:0009636,biological_process response to toxic substance;GO:0010033,biological_process response to organic substance;GO:0010165,biological_process response to X-ray;GO:0010243,biological_process response to organonitrogen compound;GO:0010629,biological_process negative regulation of gene expression;GO:0010942,biological_process positive regulation of cell death;GO:0014070,biological_process response to organic cyclic compound;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0019901,molecular_function protein kinase binding;GO:0019912,molecular_function cyclin-dependent protein kinase activating kinase activity;GO:0030308,biological_process negative regulation of cell growth;GO:0030332,molecular_function cyclin binding;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031100,biological_process organ regeneration;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032403,molecular_function protein complex binding;GO:0033158,biological_process regulation of protein import into nucleus, translocation;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034605,biological_process cellular response to heat;GO:0042326,biological_process negative regulation of phosphorylation;GO:0042493,biological_process response to drug;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043068,biological_process positive regulation of programmed cell death;GO:0043234,cellular_component protein complex;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046685,biological_process response to arsenic-containing substance;GO:0046872,molecular_function metal ion binding;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0051384,biological_process response to glucocorticoid;GO:0051412,biological_process response to corticosterone;GO:0051726,biological_process regulation of cell cycle;GO:0055093,biological_process response to hyperoxia;GO:0060574,biological_process intestinal epithelial cell maturation;GO:0070557,cellular_component PCNA-p21 complex;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071480,biological_process cellular response to gamma radiation;GO:0071493,biological_process cellular response to UV-B;GO:0071850,biological_process mitotic cell cycle arrest;GO:0072331,biological_process signal transduction by p53 class mediator;GO:0090398,biological_process cellular senescence;GO:0090399,biological_process replicative senescence;GO:0090400,biological_process stress-induced premature senescence;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1904030,biological_process negative regulation of cyclin-dependent protein kinase activity;GO:1904031,biological_process positive regulation of cyclin-dependent protein kinase activity;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle;GO:2000278,biological_process regulation of DNA biosynthetic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	NA	cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol%3BAcc:HGNC:1784]
ENSG00000155256	25.01	23.81	24.42	32.16	30.87	28.96	-0.314250528630162	5.11259800344043	3.07773352465855e-05	0.00166829284897758	10:97737120-97760907:+	ZFYVE27	23;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031175,biological_process neuron projection development;GO:0032584,cellular_component growth cone membrane;GO:0042995,cellular_component cell projection;GO:0043621,molecular_function protein self-association;GO:0045773,biological_process positive regulation of axon extension;GO:0046872,molecular_function metal ion binding;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0055038,cellular_component recycling endosome membrane;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0071787,biological_process endoplasmic reticulum tubular network assembly;GO:0072659,biological_process protein localization to plasma membrane	NA	zinc finger FYVE-type containing 27 [Source:HGNC Symbol%3BAcc:HGNC:26559]
ENSG00000081059	6.50	6.53	5.19	9.29	7.61	9.65	-0.53630610394838	3.78050755120874	3.12443518069934e-05	0.00168624408252265	5:134114710-134151865:+	TCF7	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001047,molecular_function core promoter binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005719,cellular_component nuclear euchromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0008013,molecular_function beta-catenin binding;GO:0016055,biological_process Wnt signaling pathway;GO:0016604,cellular_component nuclear body;GO:0021915,biological_process neural tube development;GO:0030538,biological_process embryonic genitalia morphogenesis;GO:0033153,biological_process T cell receptor V(D)J recombination;GO:0042127,biological_process regulation of cell proliferation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044336,biological_process canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0046632,biological_process alpha-beta T cell differentiation;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048619,biological_process embryonic hindgut morphogenesis;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0071353,biological_process cellular response to interleukin-4;GO:1904837,biological_process beta-catenin-TCF complex assembly	TCF7, TCF-1; transcription factor 7; K02620	transcription factor 7 [Source:HGNC Symbol%3BAcc:HGNC:11639]
ENSG00000116106	6.04	6.23	6.20	4.58	4.89	4.75	0.387550965835263	4.03666709630649	3.20835478980116e-05	0.00172403930761047	2:221418026-221574202:-	EPHA4	79;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005003,molecular_function ephrin receptor activity;GO:0005004,molecular_function GPI-linked ephrin receptor activity;GO:0005005,molecular_function transmembrane-ephrin receptor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007628,biological_process adult walking behavior;GO:0008045,biological_process motor neuron axon guidance;GO:0008347,biological_process glial cell migration;GO:0009986,cellular_component cell surface;GO:0010977,biological_process negative regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021957,biological_process corticospinal tract morphogenesis;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031594,cellular_component neuromuscular junction;GO:0031901,cellular_component early endosome membrane;GO:0042731,molecular_function PH domain binding;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043087,biological_process regulation of GTPase activity;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0043204,cellular_component perikaryon;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043679,cellular_component axon terminus;GO:0044295,cellular_component axonal growth cone;GO:0044297,cellular_component cell body;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046777,biological_process protein autophosphorylation;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048681,biological_process negative regulation of axon regeneration;GO:0048710,biological_process regulation of astrocyte differentiation;GO:0050770,biological_process regulation of axonogenesis;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0050821,biological_process protein stabilization;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0072178,biological_process nephric duct morphogenesis;GO:0097155,biological_process fasciculation of sensory neuron axon;GO:0097156,biological_process fasciculation of motor neuron axon;GO:0097161,molecular_function DH domain binding;GO:0097485,biological_process neuron projection guidance;GO:0106030,Biological_Process neuron projection fasciculation;GO:1900272,biological_process negative regulation of long-term synaptic potentiation;GO:1902004,biological_process positive regulation of beta-amyloid formation;GO:1902961,biological_process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1903051,biological_process negative regulation of proteolysis involved in cellular protein catabolic process;GO:1904646,biological_process cellular response to beta-amyloid;GO:1905244,biological_process regulation of modification of synaptic structure;GO:1990782,molecular_function protein tyrosine kinase binding;GO:2001108,biological_process positive regulation of Rho guanyl-nucleotide exchange factor activity	EPHA4, SEK, TYRO1; Eph receptor A4 [EC:2.7.10.1]; K05105	EPH receptor A4 [Source:HGNC Symbol%3BAcc:HGNC:3388]
ENSG00000183018	30.69	31.92	32.20	38.18	38.72	37.69	-0.262345971627958	6.12983686315267	3.23705468742407e-05	0.00173196378599116	17:4498837-4539035:+	SPNS2	19;GO:0001782,biological_process B cell homeostasis;GO:0002260,biological_process lymphocyte homeostasis;GO:0002920,biological_process regulation of humoral immune response;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0005765,cellular_component lysosomal membrane;GO:0006665,biological_process sphingolipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031982,cellular_component vesicle;GO:0040011,biological_process locomotion;GO:0043029,biological_process T cell homeostasis;GO:0046624,molecular_function sphingolipid transporter activity;GO:0048073,biological_process regulation of eye pigmentation;GO:0048535,biological_process lymph node development;GO:0055085,biological_process transmembrane transport;GO:0060348,biological_process bone development;GO:0072676,biological_process lymphocyte migration	NA	sphingolipid transporter 2 [Source:HGNC Symbol%3BAcc:HGNC:26992]
ENSG00000112769	0.56	0.44	0.59	0.23	0.27	0.29	1.02625729979215	1.3047413996707	3.34010115252946e-05	0.00177942813761151	6:112108759-112254939:-	LAMA4	17;GO:0001568,biological_process blood vessel development;GO:0005102,molecular_function receptor binding;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005605,cellular_component basal lamina;GO:0005615,cellular_component extracellular space;GO:0007155,biological_process cell adhesion;GO:0030155,biological_process regulation of cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030334,biological_process regulation of cell migration;GO:0031012,cellular_component extracellular matrix;GO:0045995,biological_process regulation of embryonic development;GO:0050873,biological_process brown fat cell differentiation;GO:0070062,cellular_component extracellular exosome	LAMA4; laminin, alpha 4; K06241	laminin subunit alpha 4 [Source:HGNC Symbol%3BAcc:HGNC:6484]
ENSG00000049089	0.54	0.45	0.42	1.31	0.90	1.17	-1.23951442757863	0.89556202775345	3.39794264714137e-05	0.00180250692645153	1:40300486-40317816:-	COL9A2	8;GO:0001501,biological_process skeletal system development;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005594,cellular_component collagen type IX trimer;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0030020,molecular_function extracellular matrix structural constituent conferring tensile strength;GO:0030198,biological_process extracellular matrix organization	COL9A; collagen, type IX, alpha; K08131	collagen type IX alpha 2 chain [Source:HGNC Symbol%3BAcc:HGNC:2218]
ENSG00000115641	88.83	74.75	90.97	107.81	100.97	112.46	-0.322152709900357	7.31656026909167	3.53340681546105e-05	0.00186639058724757	2:105357711-105438513:-	FHL2	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001649,biological_process osteoblast differentiation;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0009725,biological_process response to hormone;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030018,cellular_component Z disc;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031430,cellular_component M band;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0055014,biological_process atrial cardiac muscle cell development;GO:0055015,biological_process ventricular cardiac muscle cell development;GO:0060347,biological_process heart trabecula formation	FHL2; four and a half LIM domains protein 2; K14380	four and a half LIM domains 2 [Source:HGNC Symbol%3BAcc:HGNC:3703]
ENSG00000156273	11.12	10.00	10.48	8.31	8.32	8.39	0.352949198585448	4.50398774927782	3.62166778295955e-05	0.00190490517753716	21:29194070-29630751:+	BACH1	23;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000117,biological_process regulation of transcription involved in G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001206,molecular_function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0020037,molecular_function heme binding;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia	NA	BTB domain and CNC homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:935]
ENSG00000205403	47.25	49.42	44.97	30.33	42.40	35.35	0.401552429653857	6.27906661644633	3.71809321180518e-05	0.00194737092987923	4:109740693-109802179:-	CFI	17;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006958,biological_process complement activation, classical pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030449,biological_process regulation of complement activation;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	CFI; complement factor I [EC:3.4.21.45]; K01333	complement factor I [Source:HGNC Symbol%3BAcc:HGNC:5394]
ENSG00000171160	29.00	22.15	28.05	35.01	36.80	37.16	-0.43512335467796	4.02112329020546	3.74102701621521e-05	0.00195114993076804	10:97614552-97633500:-	MORN4	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0032426,cellular_component stereocilium tip;GO:0032433,cellular_component filopodium tip;GO:0048678,biological_process response to axon injury	NA	MORN repeat containing 4 [Source:HGNC Symbol%3BAcc:HGNC:24001]
ENSG00000173432	16.60	19.58	15.28	23.12	28.60	26.51	-0.604568931283223	3.01392828672919	3.78306764368224e-05	0.00196482086447814	11:18266173-18269977:+	SAA1	25;GO:0000187,biological_process activation of MAPK activity;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006953,biological_process acute-phase response;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008201,molecular_function heparin binding;GO:0030168,biological_process platelet activation;GO:0030593,biological_process neutrophil chemotaxis;GO:0034364,cellular_component high-density lipoprotein particle;GO:0042056,molecular_function chemoattractant activity;GO:0044267,biological_process cellular protein metabolic process;GO:0045087,biological_process innate immune response;GO:0045785,biological_process positive regulation of cell adhesion;GO:0048246,biological_process macrophage chemotaxis;GO:0048247,biological_process lymphocyte chemotaxis;GO:0050708,biological_process regulation of protein secretion;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050716,biological_process positive regulation of interleukin-1 secretion;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050918,biological_process positive chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:0071682,cellular_component endocytic vesicle lumen	NA	serum amyloid A1 [Source:HGNC Symbol%3BAcc:HGNC:10513]
ENSG00000079387	7.29	7.04	7.17	9.58	9.34	9.24	-0.374772849577554	4.11144065765477	3.85990489486813e-05	0.00199637497749992	12:48042897-48106308:-	SENP1	20;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010724,biological_process regulation of definitive erythrocyte differentiation;GO:0016787,molecular_function hydrolase activity;GO:0016925,biological_process protein sumoylation;GO:0016926,biological_process protein desumoylation;GO:0016929,molecular_function SUMO-specific protease activity;GO:0031965,cellular_component nuclear membrane;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070139,molecular_function SUMO-specific endopeptidase activity;GO:0097190,biological_process apoptotic signaling pathway	NA	SUMO1/sentrin specific peptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:17927]
ENSG00000119681	3.83	2.93	4.12	2.79	2.53	2.38	0.519862565933477	4.12021000919592	4.20379432412695e-05	0.00216521572387501	14:74498169-74612378:-	LTBP2	14;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0006605,biological_process protein targeting;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008201,molecular_function heparin binding;GO:0009306,biological_process protein secretion;GO:0019838,molecular_function growth factor binding;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome;GO:0097435,biological_process fibril organization	NA	latent transforming growth factor beta binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6715]
ENSG00000186862	4.04	3.81	5.26	6.82	5.61	6.47	-0.509606226078187	4.09906451804522	4.23761864458224e-05	0.00217361819153716	10:101007682-101031157:-	PDZD7	13;GO:0002141,cellular_component stereocilia ankle link;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005929,cellular_component cilium;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0045184,biological_process establishment of protein localization;GO:0046982,molecular_function protein heterodimerization activity;GO:0050910,biological_process detection of mechanical stimulus involved in sensory perception of sound;GO:0060088,biological_process auditory receptor cell stereocilium organization;GO:0060117,biological_process auditory receptor cell development;GO:1990696,cellular_component USH2 complex	NA	PDZ domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:26257]
ENSG00000133138	6.86	7.47	7.19	5.31	5.95	5.63	0.356622822791462	4.48375117395461	4.32598231847875e-05	0.00220981146169863	X:106802679-106876145:+	TBC1D8B	8;GO:0005096,molecular_function GTPase activator activity;GO:0005509,molecular_function calcium ion binding;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 8B [Source:HGNC Symbol%3BAcc:HGNC:24715]
ENSG00000167767	33.79	30.64	32.29	42.40	36.23	44.73	-0.337609211954148	5.67820690279165	4.36398555798552e-05	0.00222008822669157	12:52168995-52192000:-	KRT80	8;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0031424,biological_process keratinization;GO:0045095,cellular_component keratin filament;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0070268,biological_process cornification	NA	keratin 80 [Source:HGNC Symbol%3BAcc:HGNC:27056]
ENSG00000197555	15.79	15.43	15.66	12.04	13.53	13.53	0.273244951632478	6.29238081245743	4.47751541713806e-05	0.00226854689277285	14:71320448-71741229:+	SIPA1L1	25;GO:0003674,molecular_function molecular_function;GO:0005096,molecular_function GTPase activator activity;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0043005,cellular_component neuron projection;GO:0043087,biological_process regulation of GTPase activity;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0050770,biological_process regulation of axonogenesis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0090630,biological_process activation of GTPase activity	NA	signal induced proliferation associated 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:20284]
ENSG00000128604	9.08	8.92	7.60	10.87	13.12	11.30	-0.453562713493018	4.05415678301987	4.71881083554078e-05	0.00238108125616129	7:128937611-128950035:+	IRF5	26;GO:0000975,molecular_function regulatory region DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032494,biological_process response to peptidoglycan;GO:0032495,biological_process response to muramyl dipeptide;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway	IRF5; interferon regulatory factor 5; K09446	interferon regulatory factor 5 [Source:HGNC Symbol%3BAcc:HGNC:6120]
ENSG00000167553	453.72	491.52	423.27	565.75	560.25	542.55	-0.274480136862313	9.87178168874152	4.8028426207177e-05	0.00241367147574772	12:49188735-49274603:+	TUBA1C	17;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031982,cellular_component vesicle;GO:0051301,biological_process cell division	TUBA; tubulin alpha; K07374	tubulin alpha 1c [Source:HGNC Symbol%3BAcc:HGNC:20768]
ENSG00000047365	0.86	0.95	0.86	1.22	1.46	1.49	-0.638930029030539	2.59656241221333	4.83817716433084e-05	0.00242162472342092	4:35948220-36244509:-	ARAP2	8;GO:0005096,molecular_function GTPase activator activity;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; K12490	ArfGAP with RhoGAP domain%2C ankyrin repeat and PH domain 2 [Source:HGNC Symbol%3BAcc:HGNC:16924]
ENSG00000174564	2.28	2.00	2.69	4.37	3.37	5.02	-0.850939684583798	1.99350544993773	4.94097296203999e-05	0.00246314447300411	3:136946229-137011085:+	IL20RB	17;GO:0001808,biological_process negative regulation of type IV hypersensitivity;GO:0002437,biological_process inflammatory response to antigenic stimulus;GO:0002765,biological_process immune response-inhibiting signal transduction;GO:0004920,molecular_function interleukin-10 receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0042015,molecular_function interleukin-20 binding;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050863,biological_process regulation of T cell activation	IL20RB; interleukin 20 receptor beta; K05137	interleukin 20 receptor subunit beta [Source:HGNC Symbol%3BAcc:HGNC:6004]
ENSG00000138439	3.00	3.35	3.62	5.25	4.68	4.89	-0.562124251375221	2.90511258900305	5.17279965792436e-05	0.0025683984861526	2:202635187-202769757:+	FAM117B	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 117 member B [Source:HGNC Symbol%3BAcc:HGNC:14440]
ENSG00000171723	8.25	9.18	7.85	6.24	6.84	6.42	0.379309093489898	4.3627873832746	5.21456521800002e-05	0.00257882063948343	14:66507406-67181803:+	GPHN	27;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006777,biological_process Mo-molybdopterin cofactor biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008940,molecular_function nitrate reductase activity;GO:0010038,biological_process response to metal ion;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0018315,biological_process molybdenum incorporation into molybdenum-molybdopterin complex;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0032324,biological_process molybdopterin cofactor biosynthetic process;GO:0042995,cellular_component cell projection;GO:0043546,molecular_function molybdopterin cofactor binding;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0061598,molecular_function molybdopterin adenylyltransferase activity;GO:0061599,molecular_function molybdopterin molybdotransferase activity;GO:0072579,biological_process glycine receptor clustering;GO:0097112,biological_process gamma-aminobutyric acid receptor clustering	GPHN; gephyrin [EC:2.10.1.1 2.7.7.75]; K15376	gephyrin [Source:HGNC Symbol%3BAcc:HGNC:15465]
ENSG00000130822	2.50	2.15	2.71	1.22	1.24	1.53	0.896544789449676	1.54926914243846	5.47580085941269e-05	0.00269726651063054	X:153669729-153689010:-	PNCK	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0035556,biological_process intracellular signal transduction	NA	pregnancy up-regulated nonubiquitous CaM kinase [Source:HGNC Symbol%3BAcc:HGNC:13415]
ENSG00000177426	122.29	121.50	122.55	145.08	142.40	147.37	-0.235594961206331	7.57929469964035	5.75678105198275e-05	0.00282446336752023	18:3411607-3459978:+	TGIF1	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0010629,biological_process negative regulation of gene expression;GO:0042493,biological_process response to drug;GO:0070410,molecular_function co-SMAD binding;GO:0071363,biological_process cellular response to growth factor stimulus	NA	TGFB induced factor homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:11776]
ENSG00000143630	5.11	5.35	5.07	3.77	4.08	3.36	0.480330748214123	3.38540833695137	5.82017521144542e-05	0.0028443242086485	1:155277582-155289848:+	HCN3	29;GO:0000166,molecular_function nucleotide binding;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005248,molecular_function voltage-gated sodium channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030552,molecular_function cAMP binding;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0043025,cellular_component neuronal cell body;GO:0044316,cellular_component cone cell pedicle;GO:0045202,cellular_component synapse;GO:0055085,biological_process transmembrane transport;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0071805,biological_process potassium ion transmembrane transport;GO:0072718,biological_process response to cisplatin;GO:1903351,biological_process cellular response to dopamine	HCN3; hyperpolarization activated cyclic nucleotide-gated potassium channel 3; K04956	hyperpolarization activated cyclic nucleotide gated potassium channel 3 [Source:HGNC Symbol%3BAcc:HGNC:19183]
ENSG00000103047	5.00	4.54	4.57	5.88	6.41	6.17	-0.372287832336048	4.20170635637833	5.90635870388883e-05	0.0028751227682891	16:68843603-69085180:+	TANGO6	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transport and golgi organization 6 homolog [Source:HGNC Symbol%3BAcc:HGNC:25749]
ENSG00000169851	3.10	3.38	2.99	2.27	2.36	2.29	0.456707781623028	3.45742825770065	6.39222127797652e-05	0.00309426690900222	4:30720414-31146805:+	PCDH7	9;GO:0002576,biological_process platelet degranulation;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031092,cellular_component platelet alpha granule membrane	NA	protocadherin 7 [Source:HGNC Symbol%3BAcc:HGNC:8659]
ENSG00000120802	26.01	25.15	25.04	30.88	29.03	32.40	-0.265031967291772	6.38198752274567	6.40649130236339e-05	0.00309426690900222	12:98515511-98550379:+	TMPO	14;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0045296,molecular_function cadherin binding	NA	thymopoietin [Source:HGNC Symbol%3BAcc:HGNC:11875]
ENSG00000109685	35.93	36.48	35.09	43.91	41.65	42.63	-0.24269114779044	7.43586062128253	6.43132894967029e-05	0.00309426690900222	4:1871423-1982207:+	NSD2	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003149,biological_process membranous septum morphogenesis;GO:0003289,biological_process atrial septum primum morphogenesis;GO:0003290,biological_process atrial septum secundum morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010452,biological_process histone H3-K36 methylation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034770,biological_process histone H4-K20 methylation;GO:0042799,molecular_function histone methyltransferase activity (H4-K20 specific);GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:0048298,biological_process positive regulation of isotype switching to IgA isotypes;GO:0060348,biological_process bone development;GO:0070201,biological_process regulation of establishment of protein localization;GO:2001032,biological_process regulation of double-strand break repair via nonhomologous end joining	WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357]; K11424	nuclear receptor binding SET domain protein 2 [Source:HGNC Symbol%3BAcc:HGNC:12766]
ENSG00000101842	7.85	6.55	9.16	5.31	5.74	4.43	0.629916237943801	3.07280269012368	6.46350854770532e-05	0.00309774253292147	X:108044969-108079184:+	VSIG1	5;GO:0003382,biological_process epithelial cell morphogenesis;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030277,biological_process maintenance of gastrointestinal epithelium	NA	V-set and immunoglobulin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28675]
ENSG00000078269	30.59	29.61	30.16	36.92	34.74	36.21	-0.243442947969273	7.29026833002639	6.52810245156e-05	0.00311666675889286	6:157981886-158099176:+	SYNJ2	23;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030424,cellular_component axon;GO:0034595,molecular_function phosphatidylinositol phosphate 5-phosphatase activity;GO:0034596,molecular_function phosphatidylinositol phosphate 4-phosphatase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0042578,molecular_function phosphoric ester hydrolase activity;GO:0042995,cellular_component cell projection;GO:0043813,molecular_function phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0045121,cellular_component membrane raft;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0061024,biological_process membrane organization	INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]; K01099	synaptojanin 2 [Source:HGNC Symbol%3BAcc:HGNC:11504]
ENSG00000176678	4.16	4.06	4.12	6.94	5.50	7.34	-0.668101181023777	2.521300596437	6.61991217042599e-05	0.00314838964641754	16:86576367-86582160:+	FOXL1	18;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007495,biological_process visceral mesoderm-endoderm interaction involved in midgut development;GO:0007507,biological_process heart development;GO:0008301,molecular_function DNA binding, bending;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009887,biological_process organ morphogenesis;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030154,biological_process cell differentiation;GO:0030166,biological_process proteoglycan biosynthetic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0061146,biological_process Peyer's patch morphogenesis	NA	forkhead box L1 [Source:HGNC Symbol%3BAcc:HGNC:3817]
ENSG00000171174	20.15	20.59	18.61	25.23	26.69	23.69	-0.339080183937917	4.76692222208768	6.77035011616034e-05	0.0032076471752633	2:27781363-27891098:-	RBKS	19;GO:0000166,molecular_function nucleotide binding;GO:0004747,molecular_function ribokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006014,biological_process D-ribose metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019200,molecular_function carbohydrate kinase activity;GO:0019303,biological_process D-ribose catabolic process;GO:0046835,biological_process carbohydrate phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	rbsK, RBKS; ribokinase [EC:2.7.1.15]; K00852	ribokinase [Source:HGNC Symbol%3BAcc:HGNC:30325]
ENSG00000104763	53.22	59.68	52.63	44.33	47.87	44.53	0.285520865349708	6.61491928089427	6.82791263366653e-05	0.00322261899322063	8:18055991-18084998:-	ASAH1	16;GO:0003824,molecular_function catalytic activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0006629,biological_process lipid metabolic process;GO:0006672,biological_process ceramide metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017040,molecular_function ceramidase activity;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	ASAH1; acid ceramidase [EC:3.5.1.23]; K12348	N-acylsphingosine amidohydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:735]
ENSG00000196569	1.04	1.00	1.13	1.35	1.67	1.46	-0.479545525796723	3.60287925141974	6.87385946296121e-05	0.0032320158149143	6:128883140-129516569:+	LAMA2	20;GO:0005102,molecular_function receptor binding;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005605,cellular_component basal lamina;GO:0005615,cellular_component extracellular space;GO:0007155,biological_process cell adhesion;GO:0007411,biological_process axon guidance;GO:0007517,biological_process muscle organ development;GO:0014037,biological_process Schwann cell differentiation;GO:0030155,biological_process regulation of cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030334,biological_process regulation of cell migration;GO:0031012,cellular_component extracellular matrix;GO:0032224,biological_process positive regulation of synaptic transmission, cholinergic;GO:0042383,cellular_component sarcolemma;GO:0043197,cellular_component dendritic spine;GO:0045995,biological_process regulation of embryonic development;GO:0070062,cellular_component extracellular exosome	LAMA1_2; laminin, alpha 1/2; K05637	laminin subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:6482]
ENSG00000148840	8.23	7.79	7.98	6.99	6.52	6.13	0.304085001673127	5.1876916443965	7.00565681684918e-05	0.00328155539877543	10:102132993-102150331:+	PPRC1	14;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003676,molecular_function nucleic acid binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007005,biological_process mitochondrion organization;GO:0008134,molecular_function transcription factor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	peroxisome proliferator-activated receptor gamma%2C coactivator-related 1 [Source:HGNC Symbol%3BAcc:HGNC:30025]
ENSG00000149485	58.33	66.20	60.75	51.74	52.58	49.62	0.277155810952449	6.59816856811402	7.1854829663732e-05	0.0033531353406613	11:61799624-61829318:-	FADS1	34;GO:0000248,molecular_function C-5 sterol desaturase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0007267,biological_process cell-cell signaling;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009267,biological_process cellular response to starvation;GO:0009744,biological_process response to sucrose;GO:0010033,biological_process response to organic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016717,molecular_function oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019369,biological_process arachidonic acid metabolic process;GO:0032868,biological_process response to insulin;GO:0033189,biological_process response to vitamin A;GO:0035900,biological_process response to isolation stress;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043651,biological_process linoleic acid metabolic process;GO:0045485,molecular_function omega-6 fatty acid desaturase activity;GO:0045595,biological_process regulation of cell differentiation;GO:0046456,biological_process icosanoid biosynthetic process;GO:0055114,biological_process oxidation-reduction process	FADS1; acyl-CoA (8-3)-desaturase (Delta-5 desaturase) [EC:1.14.19.44]; K10224	fatty acid desaturase 1 [Source:HGNC Symbol%3BAcc:HGNC:3574]
ENSG00000046774	1.51	2.05	1.18	0.54	0.54	0.69	1.39056943719048	0.41329983820068	7.40606525238184e-05	0.0034431268905549	X:142202344-142205290:-	MAGEC2	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0044257,biological_process cellular protein catabolic process;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity	NA	MAGE family member C2 [Source:HGNC Symbol%3BAcc:HGNC:13574]
ENSG00000031081	6.60	7.24	6.61	5.07	5.57	5.68	0.331727887249542	4.73879723965509	7.45488831808928e-05	0.00345289286165829	3:119294372-119420714:+	ARHGAP31	11;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 31 [Source:HGNC Symbol%3BAcc:HGNC:29216]
ENSG00000125354	11.16	10.18	9.74	14.88	14.56	12.60	-0.420173454055148	4.02929290688846	7.56252996038682e-05	0.0034842240568286	X:119615723-119693370:-	SEPT6	25;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000910,biological_process cytokinesis;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005940,cellular_component septin ring;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0008021,cellular_component synaptic vesicle;GO:0016032,biological_process viral process;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0031105,cellular_component septin complex;GO:0032154,cellular_component cleavage furrow;GO:0032173,cellular_component septin collar;GO:0042995,cellular_component cell projection;GO:0043679,cellular_component axon terminus;GO:0051301,biological_process cell division;GO:0097227,cellular_component sperm annulus	SEPT6_8_11; septin 6/8/11; K16939	septin 6 [Source:HGNC Symbol%3BAcc:HGNC:15848]
ENSG00000120694	29.83	31.95	27.64	21.88	26.11	24.55	0.311713676278515	6.19601264508126	7.57867151650466e-05	0.0034842240568286	13:31134973-31162388:-	HSPH1	26;GO:0000166,molecular_function nucleotide binding;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006986,biological_process response to unfolded protein;GO:0043014,molecular_function alpha-tubulin binding;GO:0043234,cellular_component protein complex;GO:0045345,biological_process positive regulation of MHC class I biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051135,biological_process positive regulation of NK T cell activation;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0071682,cellular_component endocytic vesicle lumen;GO:1900034,biological_process regulation of cellular response to heat;GO:1903748,biological_process negative regulation of establishment of protein localization to mitochondrion;GO:1903751,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:1903753,biological_process negative regulation of p38MAPK cascade;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	HSP110; heat shock protein 110kDa; K09485	heat shock protein family H (Hsp110) member 1 [Source:HGNC Symbol%3BAcc:HGNC:16969]
ENSG00000142102	23.43	21.72	27.10	18.99	17.50	20.64	0.352519528085996	5.64203420213014	7.66012072211388e-05	0.00350867448426567	11:289134-296107:+	PGGHG	8;GO:0003824,molecular_function catalytic activity;GO:0005618,cellular_component cell wall;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0047402,molecular_function protein-glucosylgalactosylhydroxylysine glucosidase activity	NA	protein-glucosylgalactosylhydroxylysine glucosidase [Source:HGNC Symbol%3BAcc:HGNC:26210]
ENSG00000087842	28.90	26.80	27.16	19.71	23.36	21.98	0.363168051499885	4.43195656985777	7.86677731223132e-05	0.00359008480796792	X:15384798-15493564:-	PIR	17;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007586,biological_process digestion;GO:0008127,molecular_function quercetin 2,3-dioxygenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0030099,biological_process myeloid cell differentiation;GO:0030224,biological_process monocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	pirin [Source:HGNC Symbol%3BAcc:HGNC:30048]
ENSG00000153898	1.37	2.19	1.34	2.65	2.95	3.02	-0.832883725457392	1.99193962869626	7.93791110576516e-05	0.0036092780423393	1:84925582-84997113:-	MCOLN2	7;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070588,biological_process calcium ion transmembrane transport	NA	mucolipin 2 [Source:HGNC Symbol%3BAcc:HGNC:13357]
ENSG00000106976	39.48	39.79	40.17	35.41	33.10	32.53	0.253446449973383	6.83326705594397	8.14933204685681e-05	0.00367918884819415	9:128191654-128255248:+	DNM1	45;GO:0000166,molecular_function nucleotide binding;GO:0000266,biological_process mitochondrial fission;GO:0001917,cellular_component photoreceptor inner segment;GO:0002031,biological_process G-protein coupled receptor internalization;GO:0003374,biological_process dynamin polymerization involved in mitochondrial fission;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007032,biological_process endosome organization;GO:0007605,biological_process sensory perception of sound;GO:0008017,molecular_function microtubule binding;GO:0008021,cellular_component synaptic vesicle;GO:0008022,molecular_function protein C-terminus binding;GO:0008344,biological_process adult locomotory behavior;GO:0016185,biological_process synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0030117,cellular_component membrane coat;GO:0031623,biological_process receptor internalization;GO:0031749,molecular_function D2 dopamine receptor binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032403,molecular_function protein complex binding;GO:0042802,molecular_function identical protein binding;GO:0043196,cellular_component varicosity;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0045202,cellular_component synapse;GO:0046983,molecular_function protein dimerization activity;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0051262,biological_process protein tetramerization;GO:0051932,biological_process synaptic transmission, GABAergic;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome;GO:0072583,biological_process clathrin-mediated endocytosis;GO:1901998,biological_process toxin transport;GO:1903423,biological_process positive regulation of synaptic vesicle recycling	DNM1_3; dynamin 1/3 [EC:3.6.5.5]; K01528	dynamin 1 [Source:HGNC Symbol%3BAcc:HGNC:2972]
ENSG00000128059	17.84	18.04	19.16	21.66	23.11	23.13	-0.290593339419324	5.12347564718553	8.15094605053888e-05	0.00367918884819415	4:56393361-56435615:-	PPAT	26;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0001822,biological_process kidney development;GO:0003824,molecular_function catalytic activity;GO:0004044,molecular_function amidophosphoribosyltransferase activity;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006189,biological_process 'de novo' IMP biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0006543,biological_process glutamine catabolic process;GO:0007595,biological_process lactation;GO:0008152,biological_process metabolic process;GO:0009113,biological_process purine nucleobase biosynthetic process;GO:0009116,biological_process nucleoside metabolic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019693,biological_process ribose phosphate metabolic process;GO:0031100,biological_process organ regeneration;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035690,biological_process cellular response to drug;GO:0042493,biological_process response to drug;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0060135,biological_process maternal process involved in female pregnancy	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]; K00764	phosphoribosyl pyrophosphate amidotransferase [Source:HGNC Symbol%3BAcc:HGNC:9238]
ENSG00000046604	90.32	86.55	88.56	100.74	104.42	110.81	-0.239380876936274	8.34845911817508	8.33459229563909e-05	0.00372696331897914	18:31498042-31549008:+	DSG2	27;GO:0001533,cellular_component cornified envelope;GO:0002934,biological_process desmosome organization;GO:0003165,biological_process Purkinje myocyte development;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009986,cellular_component cell surface;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0031424,biological_process keratinization;GO:0032570,biological_process response to progesterone;GO:0046872,molecular_function metal ion binding;GO:0050839,molecular_function cell adhesion molecule binding;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0086073,biological_process bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086083,molecular_function cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential	DSG2; desmoglein 2; K07597	desmoglein 2 [Source:HGNC Symbol%3BAcc:HGNC:3049]
ENSG00000169715	64.62	62.42	65.14	79.97	76.97	79.00	-0.282242631926733	5.07756545774885	8.34102599953166e-05	0.00372696331897914	16:56625474-56627112:+	MT1E	8;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0045926,biological_process negative regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071276,biological_process cellular response to cadmium ion;GO:0071294,biological_process cellular response to zinc ion	MT1_2; metallothionein 1/2; K14739	metallothionein 1E [Source:HGNC Symbol%3BAcc:HGNC:7397]
ENSG00000122035	6.71	5.66	5.88	3.20	3.34	4.16	0.782852523289443	1.86756443999194	8.34686057098366e-05	0.00372696331897914	13:27270326-27273690:+	RASL11A	10;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter	NA	RAS like family 11 member A [Source:HGNC Symbol%3BAcc:HGNC:23802]
ENSG00000124882	60.74	42.60	58.36	107.80	57.89	103.88	-0.72259622504892	5.20460203281469	8.67239856088357e-05	0.00385844026294795	4:74365142-74388751:+	EREG	59;GO:0000165,biological_process MAPK cascade;GO:0001525,biological_process angiogenesis;GO:0001550,biological_process ovarian cumulus expansion;GO:0001556,biological_process oocyte maturation;GO:0001819,biological_process positive regulation of cytokine production;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007143,biological_process female meiotic division;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009299,biological_process mRNA transcription;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009887,biological_process organ morphogenesis;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030154,biological_process cell differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030728,biological_process ovulation;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042060,biological_process wound healing;GO:0042108,biological_process positive regulation of cytokine biosynthetic process;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042700,biological_process luteinizing hormone signaling pathway;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043616,biological_process keratinocyte proliferation;GO:0045089,biological_process positive regulation of innate immune response;GO:0045410,biological_process positive regulation of interleukin-6 biosynthetic process;GO:0045740,biological_process positive regulation of DNA replication;GO:0045741,biological_process positive regulation of epidermal growth factor-activated receptor activity;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048160,biological_process primary follicle stage;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051151,biological_process negative regulation of smooth muscle cell differentiation;GO:0051781,biological_process positive regulation of cell division;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:2000145,biological_process regulation of cell motility	EREG; epiregulin; K09784	epiregulin [Source:HGNC Symbol%3BAcc:HGNC:3443]
ENSG00000198363	274.05	296.08	280.77	235.77	244.59	248.27	0.235519462038234	9.68103112071014	8.7510719020528e-05	0.00387953769714933	8:61500555-61714640:-	ASPH	33;GO:0004597,molecular_function peptide-aspartate beta-dioxygenase activity;GO:0005198,molecular_function structural molecule activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006936,biological_process muscle contraction;GO:0007389,biological_process pattern specification process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008307,molecular_function structural constituent of muscle;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0018193,biological_process peptidyl-amino acid modification;GO:0031647,biological_process regulation of protein stability;GO:0032541,cellular_component cortical endoplasmic reticulum;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034220,biological_process ion transmembrane transport;GO:0035108,biological_process limb morphogenesis;GO:0042264,biological_process peptidyl-aspartic acid hydroxylation;GO:0045862,biological_process positive regulation of proteolysis;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:1901879,biological_process regulation of protein depolymerization;GO:1903779,biological_process regulation of cardiac conduction	ASPH; aspartate beta-hydroxylase [EC:1.14.11.16]; K00476	aspartate beta-hydroxylase [Source:HGNC Symbol%3BAcc:HGNC:757]
ENSG00000166136	14.78	15.74	15.40	23.19	23.74	18.65	-0.502352858693631	3.5182455449381	9.19841130640593e-05	0.00406334090912515	10:100523739-100530000:-	NDUFB8	12;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005783,cellular_component endoplasmic reticulum;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8; K03964	NADH:ubiquinone oxidoreductase subunit B8 [Source:HGNC Symbol%3BAcc:HGNC:7703]
ENSG00000165655	11.33	14.15	12.19	9.08	10.37	9.14	0.40256134902133	4.42170815539905	9.45395611009252e-05	0.00416141692179356	10:75397829-75401906:-	ZNF503	9;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0046872,molecular_function metal ion binding;GO:0061351,biological_process neural precursor cell proliferation;GO:0070315,biological_process G1 to G0 transition involved in cell differentiation	NA	zinc finger protein 503 [Source:HGNC Symbol%3BAcc:HGNC:23589]
ENSG00000177119	31.38	31.52	33.10	38.19	37.16	39.54	-0.247114806731946	6.7874697796538	9.72227378121468e-05	0.00426440227725151	12:45215986-45440404:+	ANO6	52;GO:0002407,biological_process dendritic cell chemotaxis;GO:0002543,biological_process activation of blood coagulation via clotting cascade;GO:0005227,molecular_function calcium activated cation channel activity;GO:0005229,molecular_function intracellular calcium activated chloride channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005247,molecular_function voltage-gated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006821,biological_process chloride transport;GO:0006869,biological_process lipid transport;GO:0007596,biological_process blood coagulation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017121,biological_process phospholipid scrambling;GO:0017128,molecular_function phospholipid scramblase activity;GO:0030501,biological_process positive regulation of bone mineralization;GO:0032060,biological_process bleb assembly;GO:0034220,biological_process ion transmembrane transport;GO:0034707,cellular_component chloride channel complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0034767,biological_process positive regulation of ion transmembrane transport;GO:0035579,cellular_component specific granule membrane;GO:0035590,biological_process purinergic nucleotide receptor signaling pathway;GO:0035630,biological_process bone mineralization involved in bone maturation;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0045794,biological_process negative regulation of cell volume;GO:0046931,biological_process pore complex assembly;GO:0046983,molecular_function protein dimerization activity;GO:0060100,biological_process positive regulation of phagocytosis, engulfment;GO:0061588,biological_process calcium activated phospholipid scrambling;GO:0061589,biological_process calcium activated phosphatidylserine scrambling;GO:0061590,biological_process calcium activated phosphatidylcholine scrambling;GO:0061591,biological_process calcium activated galactosylceramide scrambling;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport;GO:0070821,cellular_component tertiary granule membrane;GO:0090026,biological_process positive regulation of monocyte chemotaxis;GO:0097045,biological_process phosphatidylserine exposure on blood platelet;GO:1902304,biological_process positive regulation of potassium ion export;GO:1902476,biological_process chloride transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process	NA	anoctamin 6 [Source:HGNC Symbol%3BAcc:HGNC:25240]
ENSG00000185201	58.52	55.97	59.00	49.80	40.93	48.55	0.329347917220059	5.0441098321631	9.8830897484654e-05	0.00430858711874231	11:307630-315272:+	IFITM2	15;GO:0002376,biological_process immune system process;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0009607,biological_process response to biotic stimulus;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034341,biological_process response to interferon-gamma;GO:0035455,biological_process response to interferon-alpha;GO:0035456,biological_process response to interferon-beta;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway	NA	interferon induced transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:5413]
ENSG00000127955	36.58	35.72	40.13	30.60	30.92	31.19	0.292457567240806	5.18856744550721	9.89242994313671e-05	0.00430858711874231	7:80133954-80219402:+	GNAI1	44;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006457,biological_process protein folding;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0019003,molecular_function GDP binding;GO:0030496,cellular_component midbody;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031821,molecular_function G-protein coupled serotonin receptor binding;GO:0032794,molecular_function GTPase activating protein binding;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0043949,biological_process regulation of cAMP-mediated signaling;GO:0045121,cellular_component membrane raft;GO:0046872,molecular_function metal ion binding;GO:0050805,biological_process negative regulation of synaptic transmission;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0070062,cellular_component extracellular exosome;GO:0099738,cellular_component cell cortex region;GO:1904322,biological_process cellular response to forskolin;GO:1904778,biological_process positive regulation of protein localization to cell cortex	GNAI; guanine nucleotide-binding protein G(i) subunit alpha; K04630	G protein subunit alpha i1 [Source:HGNC Symbol%3BAcc:HGNC:4384]
ENSG00000157557	10.79	9.58	9.78	8.09	7.60	6.40	0.467153238097743	3.62990330836582	9.95486735250475e-05	0.00432062127435809	21:38805306-38824955:+	ETS2	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0001712,biological_process ectodermal cell fate commitment;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007498,biological_process mesoderm development;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0090009,biological_process primitive streak formation	ETS1, pnt; C-ets-1; K02678	ETS proto-oncogene 2%2C transcription factor [Source:HGNC Symbol%3BAcc:HGNC:3489]
ENSG00000169439	106.11	113.51	98.58	120.39	147.94	132.30	-0.32243751239221	6.18811902746066	0.000102778375360744	0.00444525426255369	8:96493350-96611780:+	SDC2	24;GO:0001523,biological_process retinoid metabolic process;GO:0005515,molecular_function protein binding;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0007399,biological_process nervous system development;GO:0008150,biological_process biological_process;GO:0008218,biological_process bioluminescence;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0030154,biological_process cell differentiation;GO:0030165,molecular_function PDZ domain binding;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048813,biological_process dendrite morphogenesis;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0050900,biological_process leukocyte migration	SDC2, CD362; syndecan 2; K16336	syndecan 2 [Source:HGNC Symbol%3BAcc:HGNC:10659]
ENSG00000214655	14.31	14.28	15.59	12.47	12.16	12.71	0.255387508322003	6.30552500978909	0.000103359603416226	0.00445487068474171	10:73785581-73801797:+	ZSWIM8	2;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger SWIM-type containing 8 [Source:HGNC Symbol%3BAcc:HGNC:23528]
ENSG00000134324	27.78	35.37	27.26	22.69	25.68	19.67	0.419753418003976	6.31293768274512	0.000104141261410453	0.00447302933525242	2:11677594-11827409:+	LPIN1	29;GO:0003674,molecular_function molecular_function;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006642,biological_process triglyceride mobilization;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0009062,biological_process fatty acid catabolic process;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0019432,biological_process triglyceride biosynthetic process;GO:0031100,biological_process organ regeneration;GO:0031965,cellular_component nuclear membrane;GO:0032869,biological_process cellular response to insulin stimulus;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]; K15728	lipin 1 [Source:HGNC Symbol%3BAcc:HGNC:13345]
ENSG00000177459	1.38	1.36	0.98	2.07	2.77	2.69	-1.00632840882276	1.18802024159701	0.000105520804569535	0.00451665430041944	8:98064310-98093610:+	ERICH5	NA	NA	glutamate rich 5 [Source:HGNC Symbol%3BAcc:HGNC:26823]
ENSG00000150687	102.41	114.91	96.15	81.84	92.39	79.94	0.313132638482478	7.11278211526332	0.000107195079315635	0.00455873002223945	11:86791058-86952910:+	PRSS23	12;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome	NA	protease%2C serine 23 [Source:HGNC Symbol%3BAcc:HGNC:14370]
ENSG00000102878	22.30	21.18	22.14	18.51	15.73	18.70	0.322350369122421	4.99480909255459	0.000107238311970831	0.00455873002223945	16:67164680-67169945:+	HSF4	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001654,biological_process eye development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007601,biological_process visual perception;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016607,cellular_component nuclear speck;GO:0033169,biological_process histone H3-K9 demethylation;GO:0043010,biological_process camera-type eye development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048468,biological_process cell development;GO:0051260,biological_process protein homooligomerization;GO:0070207,biological_process protein homotrimerization	NA	heat shock transcription factor 4 [Source:HGNC Symbol%3BAcc:HGNC:5227]
ENSG00000072571	36.73	36.91	35.87	42.65	46.90	42.55	-0.259009704652465	6.45636850194186	0.00010845941472952	0.00459490346429194	5:163460202-163491945:+	HMMR	9;GO:0005515,molecular_function protein binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0009986,cellular_component cell surface;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0030214,biological_process hyaluronan catabolic process	HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor; K06267	hyaluronan mediated motility receptor [Source:HGNC Symbol%3BAcc:HGNC:5012]
ENSG00000166794	656.78	668.52	603.35	546.52	560.27	533.25	0.245300956973793	8.59183133314163	0.000109739300025223	0.00463331269120098	15:64155811-64163205:-	PPIB	27;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005925,cellular_component focal adhesion;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0032403,molecular_function protein complex binding;GO:0032991,cellular_component macromolecular complex;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042470,cellular_component melanosome;GO:0044794,biological_process positive regulation by host of viral process;GO:0044829,biological_process positive regulation by host of viral genome replication;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0060348,biological_process bone development;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0070063,molecular_function RNA polymerase binding	NA	peptidylprolyl isomerase B [Source:HGNC Symbol%3BAcc:HGNC:9255]
ENSG00000157514	90.92	82.80	87.45	75.87	68.24	75.02	0.266556729801034	6.17173064522254	0.000111234069603468	0.00468050341012831	X:107713220-107777342:-	TSC22D3	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006970,biological_process response to osmotic stress;GO:0034220,biological_process ion transmembrane transport;GO:0043426,molecular_function MRF binding;GO:0048642,biological_process negative regulation of skeletal muscle tissue development;GO:0070236,biological_process negative regulation of activation-induced cell death of T cells	NA	TSC22 domain family member 3 [Source:HGNC Symbol%3BAcc:HGNC:3051]
ENSG00000197457	14.14	12.89	14.24	10.20	9.40	10.25	0.483750993488365	3.14507765658463	0.000113615705868707	0.00476456674644684	20:63639704-63657682:-	STMN3	16;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0007019,biological_process microtubule depolymerization;GO:0007399,biological_process nervous system development;GO:0015631,molecular_function tubulin binding;GO:0019904,molecular_function protein domain specific binding;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031110,biological_process regulation of microtubule polymerization or depolymerization;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031175,biological_process neuron projection development;GO:0035021,biological_process negative regulation of Rac protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043087,biological_process regulation of GTPase activity;GO:0051493,biological_process regulation of cytoskeleton organization	NA	stathmin 3 [Source:HGNC Symbol%3BAcc:HGNC:15926]
ENSG00000166228	277.30	285.17	274.59	332.84	342.99	325.45	-0.247426892271319	6.582285100334	0.00011460012660511	0.00478966791767418	10:70882279-70888784:-	PCBD1	21;GO:0003713,molecular_function transcription coactivator activity;GO:0004505,molecular_function phenylalanine 4-monooxygenase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006558,biological_process L-phenylalanine metabolic process;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0006729,biological_process tetrahydrobiopterin biosynthetic process;GO:0008124,molecular_function 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;GO:0016829,molecular_function lyase activity;GO:0042802,molecular_function identical protein binding;GO:0043496,biological_process regulation of protein homodimerization activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051289,biological_process protein homotetramerization;GO:0051291,biological_process protein heterooligomerization;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	PCBD, phhB; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]; K01724	pterin-4 alpha-carbinolamine dehydratase 1 [Source:HGNC Symbol%3BAcc:HGNC:8646]
ENSG00000179532	4.89	4.25	4.97	4.09	3.42	3.93	0.31681729642884	5.94890110412357	0.000115840842052733	0.00482527641745158	11:6497259-6593758:+	DNHD1	11;GO:0003341,biological_process cilium movement;GO:0003777,molecular_function microtubule motor activity;GO:0007018,biological_process microtubule-based movement;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0030286,cellular_component dynein complex;GO:0036156,cellular_component inner dynein arm;GO:0036159,biological_process inner dynein arm assembly;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0070062,cellular_component extracellular exosome	NA	dynein heavy chain domain 1 [Source:HGNC Symbol%3BAcc:HGNC:26532]
ENSG00000145908	4.77	5.23	5.17	7.47	6.75	6.60	-0.447826521376127	3.50666615617116	0.000120683373150824	0.00501017629070628	5:150894391-150904983:-	ZNF300	14;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 300 [Source:HGNC Symbol%3BAcc:HGNC:13091]
ENSG00000163576	2.39	3.10	2.12	3.55	4.54	3.58	-0.618263592501761	3.19578279622089	0.000126274253462656	0.00521194508543664	3:19879471-19947025:-	EFHB	2;GO:0005509,molecular_function calcium ion binding;GO:0046872,molecular_function metal ion binding	NA	EF-hand domain family member B [Source:HGNC Symbol%3BAcc:HGNC:26330]
ENSG00000004534	51.71	49.36	52.32	41.59	45.52	43.57	0.243677995643449	7.35910968699097	0.000126383265182988	0.00521194508543664	3:49940006-50100045:+	RBM6	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006396,biological_process RNA processing	NA	RNA binding motif protein 6 [Source:HGNC Symbol%3BAcc:HGNC:9903]
ENSG00000171451	0.46	0.63	0.52	0.29	0.23	0.19	1.17971882566135	0.617846389555967	0.000127763068035346	0.00525140054146604	18:67506581-67516980:-	DSEL	9;GO:0000139,cellular_component Golgi membrane;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016853,molecular_function isomerase activity;GO:0030204,biological_process chondroitin sulfate metabolic process;GO:0030205,biological_process dermatan sulfate metabolic process;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0047757,molecular_function chondroitin-glucuronate 5-epimerase activity	NA	dermatan sulfate epimerase-like [Source:HGNC Symbol%3BAcc:HGNC:18144]
ENSG00000101849	15.46	18.83	18.50	23.44	21.38	22.10	-0.335573113003184	5.11736234890937	0.000129214164788737	0.00529351626245081	X:9463294-9719743:+	TBL1X	24;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005876,cellular_component spindle microtubule;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0007605,biological_process sensory perception of sound;GO:0008013,molecular_function beta-catenin binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0016575,biological_process histone deacetylation;GO:0017053,cellular_component transcriptional repressor complex;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019904,molecular_function protein domain specific binding;GO:0042393,molecular_function histone binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060070,biological_process canonical Wnt signaling pathway	TBL1; transducin (beta)-like 1; K04508	transducin beta like 1X-linked [Source:HGNC Symbol%3BAcc:HGNC:11585]
ENSG00000183049	11.03	10.56	10.21	7.40	6.55	8.88	0.486242310944309	3.47160903599483	0.000132600604389029	0.00541437928381915	10:12349481-12835545:+	CAMK1D	28;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007399,biological_process nervous system development;GO:0008152,biological_process metabolic process;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050773,biological_process regulation of dendrite development;GO:0060267,biological_process positive regulation of respiratory burst;GO:0071622,biological_process regulation of granulocyte chemotaxis;GO:0090023,biological_process positive regulation of neutrophil chemotaxis	CAMK1; calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]; K08794	calcium/calmodulin dependent protein kinase ID [Source:HGNC Symbol%3BAcc:HGNC:19341]
ENSG00000185813	26.76	30.39	23.87	19.43	23.34	18.86	0.402699833225421	4.91007662311001	0.000137062889352112	0.00557823490336973	17:81900964-81911464:-	PCYT2	10;GO:0003824,molecular_function catalytic activity;GO:0004306,molecular_function ethanolamine-phosphate cytidylyltransferase activity;GO:0005575,cellular_component cellular_component;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity	PCYT2; ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14]; K00967	phosphate cytidylyltransferase 2%2C ethanolamine [Source:HGNC Symbol%3BAcc:HGNC:8756]
ENSG00000113361	161.55	178.82	169.87	128.31	156.31	132.06	0.303843773890727	8.58148565924104	0.00013762911612366	0.00558297457007513	5:31193749-31329146:+	CDH6	10;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007219,biological_process Notch signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034332,biological_process adherens junction organization;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	cadherin 6 [Source:HGNC Symbol%3BAcc:HGNC:1765]
ENSG00000095539	3.35	3.78	4.09	4.98	4.84	5.42	-0.433156973539803	3.71458120146617	0.000139125184885806	0.00562527986966617	10:100969517-100985871:+	SEMA4G	9;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0050919,biological_process negative chemotaxis	SEMA4, CD100; semaphorin 4; K06521	semaphorin 4G [Source:HGNC Symbol%3BAcc:HGNC:10735]
ENSG00000227471	6.09	3.80	6.28	3.34	3.31	2.79	0.80810503603592	2.1960893790955	0.000147928692073137	0.00596181446332419	7:134549135-134579875:+	AKR1B15	8;GO:0004303,molecular_function estradiol 17-beta-dehydrogenase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006703,biological_process estrogen biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	aldo-keto reductase family 1 member B15 [Source:HGNC Symbol%3BAcc:HGNC:37281]
ENSG00000131016	20.75	19.82	21.14	25.45	22.97	26.07	-0.259028154408668	6.93457494191227	0.000149330711400512	0.00599884181428657	6:151239998-151358557:+	AKAP12	16;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006605,biological_process protein targeting;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008179,molecular_function adenylate cyclase binding;GO:0010739,biological_process positive regulation of protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0051018,molecular_function protein kinase A binding;GO:0090036,biological_process regulation of protein kinase C signaling	NA	A-kinase anchoring protein 12 [Source:HGNC Symbol%3BAcc:HGNC:370]
ENSG00000115556	5.71	5.69	6.32	4.49	3.69	4.83	0.457261979204937	3.62763395778907	0.000150715737412424	0.00603494983387234	2:218607764-218637184:+	PLCD4	23;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007340,biological_process acrosome reaction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0031965,cellular_component nuclear membrane;GO:0035556,biological_process intracellular signal transduction;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046872,molecular_function metal ion binding	PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]; K05857	phospholipase C delta 4 [Source:HGNC Symbol%3BAcc:HGNC:9062]
ENSG00000069535	0.81	1.35	1.04	0.29	0.53	0.41	1.35381690639301	0.342955752260765	0.0001553408741766	0.00620014878184611	X:43766610-43882447:-	MAOB	27;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008131,molecular_function primary amine oxidase activity;GO:0009055,molecular_function electron carrier activity;GO:0009636,biological_process response to toxic substance;GO:0010044,biological_process response to aluminum ion;GO:0010269,biological_process response to selenium ion;GO:0014063,biological_process negative regulation of serotonin secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0021762,biological_process substantia nigra development;GO:0032496,biological_process response to lipopolysaccharide;GO:0042135,biological_process neurotransmitter catabolic process;GO:0042420,biological_process dopamine catabolic process;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0045471,biological_process response to ethanol;GO:0045964,biological_process positive regulation of dopamine metabolic process;GO:0048545,biological_process response to steroid hormone;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050665,biological_process hydrogen peroxide biosynthetic process;GO:0051412,biological_process response to corticosterone;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	MAO, aofH; monoamine oxidase [EC:1.4.3.4]; K00274	monoamine oxidase B [Source:HGNC Symbol%3BAcc:HGNC:6834]
ENSG00000157551	13.50	11.21	13.48	20.10	14.29	20.75	-0.513251732119365	4.15269835118828	0.000159291752215932	0.0063374632059499	21:38157033-38307357:+	KCNJ15	14;GO:0005242,molecular_function inward rectifier potassium channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0010107,biological_process potassium ion import;GO:0015467,molecular_function G-protein activated inward rectifier potassium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport	KCNJ15, KIR4.2; potassium inwardly-rectifying channel subfamily J member 15; K05008	potassium voltage-gated channel subfamily J member 15 [Source:HGNC Symbol%3BAcc:HGNC:6261]
ENSG00000150961	28.41	33.79	26.29	22.57	25.41	22.45	0.338540522068581	6.45009796314005	0.000161285139860331	0.00639626977982838	4:118722822-118838683:-	SEC24D	24;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0001701,biological_process in utero embryonic development;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008270,molecular_function zinc ion binding;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030127,cellular_component COPII vesicle coat;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090110,biological_process cargo loading into COPII-coated vesicle	SEC24; protein transport protein SEC24; K14007	SEC24 homolog D%2C COPII coat complex component [Source:HGNC Symbol%3BAcc:HGNC:10706]
ENSG00000100299	21.69	21.35	22.80	18.80	18.36	17.07	0.294041071640454	4.9642406008362	0.000162544974998828	0.00642570310401419	22:50622753-50628173:-	ARSA	33;GO:0001669,cellular_component acrosomal vesicle;GO:0003824,molecular_function catalytic activity;GO:0004065,molecular_function arylsulfatase activity;GO:0004098,molecular_function cerebroside-sulfatase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006914,biological_process autophagy;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0007417,biological_process central nervous system development;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0009268,biological_process response to pH;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031232,cellular_component extrinsic component of external side of plasma membrane;GO:0035578,cellular_component azurophil granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043627,biological_process response to estrogen;GO:0043687,biological_process post-translational protein modification;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0051597,biological_process response to methylmercury;GO:0070062,cellular_component extracellular exosome	ARSA; arylsulfatase A [EC:3.1.6.8]; K01134	arylsulfatase A [Source:HGNC Symbol%3BAcc:HGNC:713]
ENSG00000261236	23.32	22.89	24.67	20.27	18.77	20.52	0.263452974497789	5.60941303059051	0.000163595064104115	0.00644479919272797	8:144262101-144291370:-	BOP1	18;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000448,biological_process cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008283,biological_process cell proliferation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0051726,biological_process regulation of cell cycle;GO:0070545,cellular_component PeBoW complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	block of proliferation 1 [Source:HGNC Symbol%3BAcc:HGNC:15519]
ENSG00000166311	22.62	27.19	24.22	16.15	21.97	18.70	0.390539206497731	5.39824629819085	0.0001644634311984	0.00644479919272797	11:6390430-6394998:+	SMPD1	30;GO:0004767,molecular_function sphingomyelin phosphodiesterase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006684,biological_process sphingomyelin metabolic process;GO:0006685,biological_process sphingomyelin catabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0023021,biological_process termination of signal transduction;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042599,cellular_component lamellar body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043202,cellular_component lysosomal lumen;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0046513,biological_process ceramide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0061750,molecular_function acid sphingomyelin phosphodiesterase activity;GO:0070062,cellular_component extracellular exosome	SMPD1, ASM; sphingomyelin phosphodiesterase [EC:3.1.4.12]; K12350	sphingomyelin phosphodiesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:11120]
ENSG00000137959	14.70	14.29	15.00	11.09	12.15	11.82	0.341109909960655	4.21367978833206	0.000164884620245758	0.00644479919272797	1:78619921-78646145:+	IFI44L	5;GO:0003674,molecular_function molecular_function;GO:0005525,molecular_function GTP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0051607,biological_process defense response to virus	NA	interferon induced protein 44 like [Source:HGNC Symbol%3BAcc:HGNC:17817]
ENSG00000167123	46.19	42.74	47.35	38.23	39.74	37.28	0.255427660306363	6.56549935613404	0.00016510482101728	0.00644479919272797	9:128411750-128437351:+	CERCAM	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0007155,biological_process cell adhesion;GO:0007159,biological_process leukocyte cell-cell adhesion	NA	cerebral endothelial cell adhesion molecule [Source:HGNC Symbol%3BAcc:HGNC:23723]
ENSG00000175265	13.33	12.19	13.00	9.55	10.19	11.16	0.331965065103312	4.5855960886513	0.000167783310033881	0.00650923538175651	15:34379067-34437466:-	GOLGA8A	4;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0032580,cellular_component Golgi cisterna membrane	NA	golgin A8 family member A [Source:HGNC Symbol%3BAcc:HGNC:31972]
ENSG00000096696	0.62	0.72	0.78	0.96	1.05	1.08	-0.530749607144115	2.93643792599504	0.000167852081389874	0.00650923538175651	6:7541574-7586717:+	DSP	43;GO:0001533,cellular_component cornified envelope;GO:0002934,biological_process desmosome organization;GO:0003223,biological_process ventricular compact myocardium morphogenesis;GO:0003723,molecular_function RNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005916,cellular_component fascia adherens;GO:0008544,biological_process epidermis development;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0018149,biological_process peptide cross-linking;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0030216,biological_process keratinocyte differentiation;GO:0030674,molecular_function protein binding, bridging;GO:0031012,cellular_component extracellular matrix;GO:0031424,biological_process keratinization;GO:0034332,biological_process adherens junction organization;GO:0042060,biological_process wound healing;GO:0043312,biological_process neutrophil degranulation;GO:0043588,biological_process skin development;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0045109,biological_process intermediate filament organization;GO:0050839,molecular_function cell adhesion molecule binding;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0071896,biological_process protein localization to adherens junction;GO:0086073,biological_process bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086083,molecular_function cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0097110,molecular_function scaffold protein binding;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential;GO:0101003,cellular_component ficolin-1-rich granule membrane	DSP; desmoplakin; K10381	desmoplakin [Source:HGNC Symbol%3BAcc:HGNC:3052]
ENSG00000139263	6.45	6.54	6.39	4.96	5.04	5.53	0.32840809796537	4.37640501401529	0.00016832873258228	0.00650923538175651	12:58872148-58920522:-	LRIG3	8;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032474,biological_process otolith morphogenesis	NA	leucine rich repeats and immunoglobulin like domains 3 [Source:HGNC Symbol%3BAcc:HGNC:30991]
ENSG00000166002	78.21	79.91	80.67	63.87	62.56	54.82	0.410578236770995	3.64411353191356	0.000169648189910206	0.00652631457758384	11:93478471-93543508:-	SMCO4	6;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	single-pass membrane protein with coiled-coil domains 4 [Source:HGNC Symbol%3BAcc:HGNC:24810]
ENSG00000089597	266.56	252.21	261.09	314.30	292.55	311.47	-0.223906139860024	9.68230332736802	0.000169821929312783	0.00652631457758384	11:62624825-62646726:-	GANAB	18;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006457,biological_process protein folding;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0017177,cellular_component glucosidase II complex;GO:0030246,molecular_function carbohydrate binding;GO:0031012,cellular_component extracellular matrix;GO:0033919,molecular_function glucan 1,3-alpha-glucosidase activity;GO:0042470,cellular_component melanosome;GO:0070062,cellular_component extracellular exosome	GANAB; mannosyl-oligosaccharide alpha-1,3-glucosidase [EC:3.2.1.207]; K05546	glucosidase II alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:4138]
ENSG00000103544	3.71	3.27	3.94	2.64	2.65	2.87	0.438699242876868	3.55983286969598	0.0001707672064657	0.00654238683289732	16:19555239-19706793:+	C16orf62	11;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043312,biological_process neutrophil degranulation;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	chromosome 16 open reading frame 62 [Source:HGNC Symbol%3BAcc:HGNC:24641]
ENSG00000075213	7.85	7.27	6.68	5.08	6.07	5.35	0.415175636189976	3.89560855952408	0.000172518780687731	0.00658915576823633	7:83955776-84492724:-	SEMA3A	47;GO:0001764,biological_process neuron migration;GO:0002027,biological_process regulation of heart rate;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007413,biological_process axonal fasciculation;GO:0008045,biological_process motor neuron axon guidance;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0010977,biological_process negative regulation of neuron projection development;GO:0021612,biological_process facial nerve structural organization;GO:0021637,biological_process trigeminal nerve structural organization;GO:0021675,biological_process nerve development;GO:0021772,biological_process olfactory bulb development;GO:0021785,biological_process branchiomotor neuron axon guidance;GO:0021828,biological_process gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0030154,biological_process cell differentiation;GO:0030215,molecular_function semaphorin receptor binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030517,biological_process negative regulation of axon extension;GO:0036486,biological_process ventral trunk neural crest cell migration;GO:0038191,molecular_function neuropilin binding;GO:0045499,molecular_function chemorepellent activity;GO:0048485,biological_process sympathetic nervous system development;GO:0048813,biological_process dendrite morphogenesis;GO:0048841,biological_process regulation of axon extension involved in axon guidance;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0048846,biological_process axon extension involved in axon guidance;GO:0048880,biological_process sensory system development;GO:0050919,biological_process negative chemotaxis;GO:0060385,biological_process axonogenesis involved in innervation;GO:0060666,biological_process dichotomous subdivision of terminal units involved in salivary gland branching;GO:0061549,biological_process sympathetic ganglion development;GO:0061551,biological_process trigeminal ganglion development;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0097490,biological_process sympathetic neuron projection extension;GO:0097491,biological_process sympathetic neuron projection guidance;GO:1901166,biological_process neural crest cell migration involved in autonomic nervous system development;GO:1902285,biological_process semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1902287,biological_process semaphorin-plexin signaling pathway involved in axon guidance;GO:1903045,biological_process neural crest cell migration involved in sympathetic nervous system development;GO:1903375,biological_process facioacoustic ganglion development;GO:2000020,biological_process positive regulation of male gonad development;GO:2001224,biological_process positive regulation of neuron migration	SEMA3; semaphorin 3; K06840	semaphorin 3A [Source:HGNC Symbol%3BAcc:HGNC:10723]
ENSG00000185291	6.23	5.90	7.72	4.82	4.35	4.03	0.608964860662291	2.67551821612983	0.000175659990154213	0.00668855048400076	X:1336615-1382689:+	IL3RA	14;GO:0000165,biological_process MAPK cascade;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004896,molecular_function cytokine receptor activity;GO:0004912,molecular_function interleukin-3 receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0036016,biological_process cellular response to interleukin-3;GO:0038156,biological_process interleukin-3-mediated signaling pathway;GO:0043547,biological_process positive regulation of GTPase activity	IL3RA, CD123; interleukin 3 receptor alpha; K04737	interleukin 3 receptor subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:6012]
ENSG00000130720	19.08	16.83	18.46	13.89	12.60	16.04	0.368384933238992	4.60807278134115	0.000177141921870578	0.00671467562977423	9:130902437-130939286:-	FIBCD1	5;GO:0005515,molecular_function protein binding;GO:0008061,molecular_function chitin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	fibrinogen C domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25922]
ENSG00000073712	45.37	42.56	45.63	37.64	38.10	38.39	0.240107367367623	6.49253093406877	0.000177427987317002	0.00671467562977423	14:52857267-52952435:-	FERMT2	31;GO:0001725,cellular_component stress fiber;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008289,molecular_function lipid binding;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030054,cellular_component cell junction;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031258,cellular_component lamellipodium membrane;GO:0031674,cellular_component I band;GO:0031941,cellular_component filamentous actin;GO:0033622,biological_process integrin activation;GO:0034329,biological_process cell junction assembly;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042995,cellular_component cell projection;GO:0048041,biological_process focal adhesion assembly;GO:0072657,biological_process protein localization to membrane	NA	fermitin family member 2 [Source:HGNC Symbol%3BAcc:HGNC:15767]
ENSG00000102271	7.23	9.74	7.93	5.47	6.81	5.55	0.485853847269416	3.98175537675368	0.000178307633178133	0.00672628323125445	X:87517748-87670050:+	KLHL4	10;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0008150,biological_process biological_process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch like family member 4 [Source:HGNC Symbol%3BAcc:HGNC:6355]
ENSG00000095564	17.59	15.67	17.70	13.89	13.86	15.09	0.26426848988676	6.44589387878337	0.00017881845374317	0.00672628323125445	10:91923768-92030325:+	BTAF1	12;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016787,molecular_function hydrolase activity;GO:0035562,biological_process negative regulation of chromatin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	B-TFIID TATA-box binding protein associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:17307]
ENSG00000149218	22.98	22.04	20.41	16.57	18.96	17.53	0.31402710804769	4.89445140960271	0.000183111949952497	0.00685992541154896	11:95089809-95132645:+	ENDOD1	11;GO:0002576,biological_process platelet degranulation;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	endonuclease domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29129]
ENSG00000100767	37.95	38.55	40.06	27.44	35.18	32.39	0.30700798890341	7.10719229706007	0.000183900383307978	0.00685992541154896	14:73237496-73274640:+	PAPLN	9;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity	NA	papilin%2C proteoglycan like sulfated glycoprotein [Source:HGNC Symbol%3BAcc:HGNC:19262]
ENSG00000100097	1894.74	1878.24	1853.36	2281.70	2106.00	2215.53	-0.219228778754724	10.1366885843142	0.000184035425963938	0.00685992541154896	22:37675607-37679806:+	LGALS1	36;GO:0002317,biological_process plasma cell differentiation;GO:0003723,molecular_function RNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0010977,biological_process negative regulation of neuron projection development;GO:0030246,molecular_function carbohydrate binding;GO:0030395,molecular_function lactose binding;GO:0031012,cellular_component extracellular matrix;GO:0031295,biological_process T cell costimulation;GO:0034120,biological_process positive regulation of erythrocyte aggregation;GO:0035900,biological_process response to isolation stress;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043236,molecular_function laminin binding;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045445,biological_process myoblast differentiation;GO:0046598,biological_process positive regulation of viral entry into host cell;GO:0048678,biological_process response to axon injury;GO:0070062,cellular_component extracellular exosome;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071407,biological_process cellular response to organic cyclic compound	NA	galectin 1 [Source:HGNC Symbol%3BAcc:HGNC:6561]
ENSG00000113552	44.33	46.37	48.29	55.53	56.17	55.15	-0.252105850293489	5.65323453846786	0.000184581896999706	0.00685992541154896	5:141991748-142013041:-	GNPDA1	11;GO:0004342,molecular_function glucosamine-6-phosphate deaminase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006043,biological_process glucosamine catabolic process;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0007338,biological_process single fertilization;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]; K02564	glucosamine-6-phosphate deaminase 1 [Source:HGNC Symbol%3BAcc:HGNC:4417]
ENSG00000185189	46.76	47.06	54.60	41.64	40.82	41.43	0.273718157384608	6.29682859524929	0.000189187295428882	0.0070100952183842	8:143833593-143840974:-	NRBP2	13;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007399,biological_process nervous system development;GO:0012505,cellular_component endomembrane system;GO:0016242,biological_process negative regulation of macroautophagy;GO:0030182,biological_process neuron differentiation;GO:0035556,biological_process intracellular signal transduction;GO:0043524,biological_process negative regulation of neuron apoptotic process	NA	nuclear receptor binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:19339]
ENSG00000100284	19.51	18.71	19.31	14.90	15.91	16.53	0.294191923282826	4.79335961572953	0.000192099550292837	0.0070968205886458	22:35299274-35347994:+	TOM1	18;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0030276,molecular_function clathrin binding;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	target of myb1 membrane trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:11982]
ENSG00000173698	5.95	5.58	7.55	4.79	3.85	5.05	0.49387935896203	4.07317240679972	0.000193818368432242	0.00713907242536918	X:18989308-19122637:-	ADGRG2	15;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0070062,cellular_component extracellular exosome	NA	adhesion G protein-coupled receptor G2 [Source:HGNC Symbol%3BAcc:HGNC:4516]
ENSG00000130164	45.54	55.20	45.11	34.11	44.07	34.39	0.384480275894345	7.09118481427207	0.00020173880579809	0.00740882779991624	19:11089361-11133816:+	LDLR	75;GO:0001540,molecular_function beta-amyloid binding;GO:0001618,molecular_function virus receptor activity;GO:0002020,molecular_function protease binding;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007616,biological_process long-term memory;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0010899,biological_process regulation of phosphatidylcholine catabolic process;GO:0010986,biological_process positive regulation of lipoprotein particle clearance;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030229,molecular_function very-low-density lipoprotein particle receptor activity;GO:0030299,biological_process intestinal cholesterol absorption;GO:0030301,biological_process cholesterol transport;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0032050,molecular_function clathrin heavy chain binding;GO:0034362,cellular_component low-density lipoprotein particle;GO:0034381,biological_process plasma lipoprotein particle clearance;GO:0034382,biological_process chylomicron remnant clearance;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0036020,cellular_component endolysosome membrane;GO:0042157,biological_process lipoprotein metabolic process;GO:0042159,biological_process lipoprotein catabolic process;GO:0042632,biological_process cholesterol homeostasis;GO:0042802,molecular_function identical protein binding;GO:0043235,cellular_component receptor complex;GO:0045177,cellular_component apical part of cell;GO:0045807,biological_process positive regulation of endocytosis;GO:0046718,biological_process viral entry into host cell;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051246,biological_process regulation of protein metabolic process;GO:0051248,biological_process negative regulation of protein metabolic process;GO:0061024,biological_process membrane organization;GO:0061771,biological_process response to caloric restriction;GO:0061889,biological_process negative regulation of astrocyte activation;GO:0070508,biological_process cholesterol import;GO:0071398,biological_process cellular response to fatty acid;GO:0071404,biological_process cellular response to low-density lipoprotein particle stimulus;GO:0090118,biological_process receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:0097242,biological_process beta-amyloid clearance;GO:0097443,cellular_component sorting endosome;GO:1900223,biological_process positive regulation of beta-amyloid clearance;GO:1903979,biological_process negative regulation of microglial cell activation;GO:1905167,biological_process positive regulation of lysosomal protein catabolic process;GO:1905907,biological_process negative regulation of amyloid fibril formation;GO:1990666,cellular_component PCSK9-LDLR complex;GO:2000188,biological_process regulation of cholesterol homeostasis	LDLR; low-density lipoprotein receptor; K12473	low density lipoprotein receptor [Source:HGNC Symbol%3BAcc:HGNC:6547]
ENSG00000109472	7.26	4.18	8.49	11.57	8.95	12.22	-0.690276173046194	3.76402745868315	0.000203552467634037	0.00745338283404515	4:165361193-165498320:+	CPE	31;GO:0003214,biological_process cardiac left ventricle morphogenesis;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0004185,molecular_function serine-type carboxypeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0007218,biological_process neuropeptide signaling pathway;GO:0008152,biological_process metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016787,molecular_function hydrolase activity;GO:0030070,biological_process insulin processing;GO:0030141,cellular_component secretory granule;GO:0030658,cellular_component transport vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042043,molecular_function neurexin family protein binding;GO:0043025,cellular_component neuronal cell body;GO:0046872,molecular_function metal ion binding;GO:0050839,molecular_function cell adhesion molecule binding;GO:0070062,cellular_component extracellular exosome;GO:0072657,biological_process protein localization to membrane;GO:0097060,cellular_component synaptic membrane	CPE; carboxypeptidase E [EC:3.4.17.10]; K01294	carboxypeptidase E [Source:HGNC Symbol%3BAcc:HGNC:2303]
ENSG00000108622	1.71	1.16	0.89	2.45	2.48	3.32	-1.10572997330484	0.875469694051937	0.000204603633432279	0.00746983794645552	17:64002593-64020634:-	ICAM2	14;GO:0001931,cellular_component uropod;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0005178,molecular_function integrin binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0032154,cellular_component cleavage furrow;GO:0050776,biological_process regulation of immune response;GO:0070062,cellular_component extracellular exosome;GO:0071944,cellular_component cell periphery	ICAM2, CD102; intercellular adhesion molecule 2; K06523	intercellular adhesion molecule 2 [Source:HGNC Symbol%3BAcc:HGNC:5345]
ENSG00000110011	27.18	22.33	24.03	20.75	17.98	18.20	0.387527161456355	4.2595904224335	0.000206086519171468	0.00748864101440612	11:64230277-64234286:+	DNAJC4	7;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006457,biological_process protein folding;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051082,molecular_function unfolded protein binding	NA	DnaJ heat shock protein family (Hsp40) member C4 [Source:HGNC Symbol%3BAcc:HGNC:5271]
ENSG00000204388	22.11	26.69	22.39	16.12	21.26	17.41	0.386336903385239	5.33536206538641	0.000206325241837339	0.00748864101440612	6:31827734-31830255:+	HSPA1B	65;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0001618,molecular_function virus receptor activity;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0003723,molecular_function RNA binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006402,biological_process mRNA catabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016234,cellular_component inclusion body;GO:0016235,cellular_component aggresome;GO:0016607,cellular_component nuclear speck;GO:0016887,molecular_function ATPase activity;GO:0019899,molecular_function enzyme binding;GO:0030308,biological_process negative regulation of cell growth;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031072,molecular_function heat shock protein binding;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031982,cellular_component vesicle;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0034599,biological_process cellular response to oxidative stress;GO:0034605,biological_process cellular response to heat;GO:0042026,biological_process protein refolding;GO:0042623,molecular_function ATPase activity, coupled;GO:0042826,molecular_function histone deacetylase binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0044183,molecular_function protein binding involved in protein folding;GO:0046034,biological_process ATP metabolic process;GO:0046718,biological_process viral entry into host cell;GO:0047485,molecular_function protein N-terminus binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0055131,molecular_function C3HC4-type RING finger domain binding;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:0070370,biological_process cellular heat acclimation;GO:0070434,biological_process positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0072562,cellular_component blood microparticle;GO:0090063,biological_process positive regulation of microtubule nucleation;GO:0090084,biological_process negative regulation of inclusion body assembly;GO:1900034,biological_process regulation of cellular response to heat;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1903265,biological_process positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	heat shock protein family A (Hsp70) member 1B [Source:HGNC Symbol%3BAcc:HGNC:5233]
ENSG00000080224	0.36	0.39	0.23	0.12	0.12	0.11	1.50341903186365	-0.0162510714811387	0.000217031687759252	0.00785426921328162	3:96814580-97752460:+	EPHA6	21;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005003,molecular_function ephrin receptor activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0048013,biological_process ephrin receptor signaling pathway	EPHA6, EHK2; Eph receptor A6 [EC:2.7.10.1]; K05107	EPH receptor A6 [Source:HGNC Symbol%3BAcc:HGNC:19296]
ENSG00000126107	20.57	18.85	19.60	16.32	16.99	16.76	0.251411605416438	5.59639802447229	0.000218421524856989	0.00788158833735408	1:45002539-45011329:-	HECTD3	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019905,molecular_function syntaxin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	HECT domain E3 ubiquitin protein ligase 3 [Source:HGNC Symbol%3BAcc:HGNC:26117]
ENSG00000142459	4.64	4.72	5.50	3.91	3.68	3.07	0.494521616832172	3.39836738216576	0.000220267862540584	0.00792517384845295	19:7830232-7864976:+	EVI5L	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0043547,biological_process positive regulation of GTPase activity;GO:0090630,biological_process activation of GTPase activity;GO:1902018,biological_process negative regulation of cilium assembly	NA	ecotropic viral integration site 5 like [Source:HGNC Symbol%3BAcc:HGNC:30464]
ENSG00000101335	50.78	56.12	56.48	39.47	48.94	37.61	0.385813654048496	4.64175156203196	0.000224430794030816	0.00805161689683385	20:36541483-36551447:+	MYL9	10;GO:0005509,molecular_function calcium ion binding;GO:0005829,cellular_component cytosol;GO:0005859,cellular_component muscle myosin complex;GO:0006936,biological_process muscle contraction;GO:0006937,biological_process regulation of muscle contraction;GO:0008307,molecular_function structural constituent of muscle;GO:0016459,cellular_component myosin complex;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0070527,biological_process platelet aggregation	NA	myosin light chain 9 [Source:HGNC Symbol%3BAcc:HGNC:15754]
ENSG00000038274	71.86	65.29	71.03	84.08	79.53	85.56	-0.245332632444756	6.38040136103206	0.000225795977118803	0.00807724917572247	5:163503113-163519336:+	MAT2B	13;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006556,biological_process S-adenosylmethionine biosynthetic process;GO:0006730,biological_process one-carbon metabolic process;GO:0019899,molecular_function enzyme binding;GO:0032259,biological_process methylation;GO:0048269,cellular_component methionine adenosyltransferase complex;GO:0048270,molecular_function methionine adenosyltransferase regulator activity;GO:0050790,biological_process regulation of catalytic activity;GO:0070062,cellular_component extracellular exosome	metK; S-adenosylmethionine synthetase [EC:2.5.1.6]; K00789	methionine adenosyltransferase 2B [Source:HGNC Symbol%3BAcc:HGNC:6905]
ENSG00000102804	36.63	35.80	37.50	32.20	31.62	30.67	0.230875197273708	6.89045278459068	0.000229111863345648	0.00817231482675151	13:44432142-44577147:-	TSC22D1	8;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity	NA	TSC22 domain family member 1 [Source:HGNC Symbol%3BAcc:HGNC:16826]
ENSG00000063978	70.84	61.49	72.93	91.91	78.14	86.00	-0.303038467583488	5.67175793342687	0.000230422121818451	0.00819550085424764	4:2462219-2625320:+	RNF4	33;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031491,molecular_function nucleosome binding;GO:0032184,molecular_function SUMO polymer binding;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046685,biological_process response to arsenic-containing substance;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0085020,biological_process protein K6-linked ubiquitination;GO:0090169,biological_process regulation of spindle assembly;GO:0090234,biological_process regulation of kinetochore assembly	NA	ring finger protein 4 [Source:HGNC Symbol%3BAcc:HGNC:10067]
ENSG00000146049	23.82	31.48	28.04	37.44	39.73	41.30	-0.510339100896297	3.11047931631588	0.00023321658138016	0.0082711926419198	6:24356902-24358284:+	KAAG1	2;GO:0005575,cellular_component cellular_component;GO:0006955,biological_process immune response	NA	kidney associated antigen 1 [Source:HGNC Symbol%3BAcc:HGNC:21031]
ENSG00000132613	31.76	28.65	34.31	40.27	36.64	38.79	-0.2736966621923	6.3066735846433	0.000236811530271567	0.00837476218023065	16:70661203-70686066:-	MTSS1L	14;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007009,biological_process plasma membrane organization;GO:0030027,cellular_component lamellipodium;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0042995,cellular_component cell projection;GO:0048365,molecular_function Rac GTPase binding;GO:0061024,biological_process membrane organization;GO:0097178,biological_process ruffle assembly;GO:0097581,biological_process lamellipodium organization	NA	MTSS1L%2C I-BAR domain containing [Source:HGNC Symbol%3BAcc:HGNC:25094]
ENSG00000145358	3.90	4.29	2.54	1.81	1.70	1.34	1.13844063156446	0.698956566009391	0.000239001147486807	0.00842818535157311	4:100185869-100190782:-	DDIT4L	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0009968,biological_process negative regulation of signal transduction	NA	DNA damage inducible transcript 4 like [Source:HGNC Symbol%3BAcc:HGNC:30555]
ENSG00000101057	36.73	37.68	33.89	43.43	44.02	41.96	-0.246653401348742	6.38204608377174	0.000249872293789952	0.00876677824450194	20:43667018-43716496:+	MYBL2	19;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001135,molecular_function transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030154,biological_process cell differentiation;GO:0031523,cellular_component Myb complex;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051726,biological_process regulation of cell cycle;GO:0090307,biological_process mitotic spindle assembly;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	MYB proto-oncogene like 2 [Source:HGNC Symbol%3BAcc:HGNC:7548]
ENSG00000131069	13.51	13.83	12.82	9.48	11.94	10.64	0.335004678741876	4.77953446650376	0.00025023946422801	0.00876677824450194	20:34872145-34927962:+	ACSS2	19;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003987,molecular_function acetate-CoA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006069,biological_process ethanol oxidation;GO:0006085,biological_process acetyl-CoA biosynthetic process;GO:0007005,biological_process mitochondrion organization;GO:0008152,biological_process metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0016208,molecular_function AMP binding;GO:0016874,molecular_function ligase activity;GO:0019413,biological_process acetate biosynthetic process;GO:0019427,biological_process acetyl-CoA biosynthetic process from acetate;GO:0019542,biological_process propionate biosynthetic process;GO:0043231,cellular_component intracellular membrane-bounded organelle	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]; K01895	acyl-CoA synthetase short chain family member 2 [Source:HGNC Symbol%3BAcc:HGNC:15814]
ENSG00000197746	958.47	964.01	1004.45	835.65	877.01	834.09	0.212521627495355	10.5038622909034	0.000250721523950551	0.00876677824450194	10:71816297-71851375:-	PSAP	41;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0002576,biological_process platelet degranulation;GO:0004565,molecular_function beta-galactosidase activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006869,biological_process lipid transport;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0008047,molecular_function enzyme activator activity;GO:0008289,molecular_function lipid binding;GO:0010506,biological_process regulation of autophagy;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0035577,cellular_component azurophil granule membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0043408,biological_process regulation of MAPK cascade;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0048589,biological_process developmental growth;GO:0060736,biological_process prostate gland growth;GO:0060742,biological_process epithelial cell differentiation involved in prostate gland development;GO:0070062,cellular_component extracellular exosome;GO:0071310,biological_process cellular response to organic substance;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death;GO:1905572,biological_process ganglioside GM1 transport to membrane;GO:1905573,molecular_function ganglioside GM1 binding;GO:1905574,molecular_function ganglioside GM2 binding;GO:1905575,molecular_function ganglioside GM3 binding;GO:1905576,molecular_function ganglioside GT1b binding;GO:1905577,molecular_function ganglioside GP1c binding	PSAP, SGP1; saposin; K12382	prosaposin [Source:HGNC Symbol%3BAcc:HGNC:9498]
ENSG00000171759	1.19	0.87	1.55	0.58	0.43	0.49	1.29474512059384	0.452092086676481	0.000260887269512147	0.00909661145071428	12:102836884-102958410:-	PAH	16;GO:0003824,molecular_function catalytic activity;GO:0004497,molecular_function monooxygenase activity;GO:0004505,molecular_function phenylalanine 4-monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005829,cellular_component cytosol;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0008152,biological_process metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009072,biological_process aromatic amino acid family metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016714,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen;GO:0042136,biological_process neurotransmitter biosynthetic process;GO:0042423,biological_process catecholamine biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	phhA, PAH; phenylalanine-4-hydroxylase [EC:1.14.16.1]; K00500	phenylalanine hydroxylase [Source:HGNC Symbol%3BAcc:HGNC:8582]
ENSG00000179542	5.63	5.86	5.36	4.47	4.50	3.72	0.418766682510647	3.63913485614362	0.000263666546453756	0.0091677670619901	X:143622789-143635777:-	SLITRK4	5;GO:0005886,cellular_component plasma membrane;GO:0007409,biological_process axonogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051965,biological_process positive regulation of synapse assembly	NA	SLIT and NTRK like family member 4 [Source:HGNC Symbol%3BAcc:HGNC:23502]
ENSG00000204682	15.06	15.93	16.42	21.29	25.84	21.20	-0.51475558321515	3.00895477443896	0.000266027675451746	0.0092240266351467	10:21492657-21497262:-	CASC10	NA	NA	cancer susceptibility 10 [Source:HGNC Symbol%3BAcc:HGNC:31448]
ENSG00000106333	13.27	9.01	11.53	7.50	7.66	8.87	0.513063964075288	3.72240086191984	0.000272353163337008	0.00941704684262475	7:100602176-100608175:+	PCOLCE	12;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0007275,biological_process multicellular organism development;GO:0008201,molecular_function heparin binding;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016504,molecular_function peptidase activator activity;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	procollagen C-endopeptidase enhancer [Source:HGNC Symbol%3BAcc:HGNC:8738]
ENSG00000112972	78.55	116.70	68.65	49.43	72.54	51.88	0.613069567015799	6.82739416068775	0.000278572528428758	0.00960533554273937	5:43289394-43313512:-	HMGCS1	37;GO:0001889,biological_process liver development;GO:0003824,molecular_function catalytic activity;GO:0004421,molecular_function hydroxymethylglutaryl-CoA synthase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0007420,biological_process brain development;GO:0008144,molecular_function drug binding;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0008584,biological_process male gonad development;GO:0009645,biological_process response to low light intensity stimulus;GO:0009725,biological_process response to hormone;GO:0010033,biological_process response to organic substance;GO:0010243,biological_process response to organonitrogen compound;GO:0014070,biological_process response to organic cyclic compound;GO:0014074,biological_process response to purine-containing compound;GO:0016126,biological_process sterol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016853,molecular_function isomerase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0033197,biological_process response to vitamin E;GO:0034698,biological_process response to gonadotropin;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043177,molecular_function organic acid binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046690,biological_process response to tellurium ion;GO:0055094,biological_process response to lipoprotein particle;GO:0070723,biological_process response to cholesterol;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0071397,biological_process cellular response to cholesterol;GO:0071407,biological_process cellular response to organic cyclic compound	E2.3.3.10; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]; K01641	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:5007]
ENSG00000143126	13.68	13.33	14.91	11.74	12.00	12.06	0.240891317337555	6.83070088005347	0.000280246099986785	0.00961866848478335	1:109250018-109275750:+	CELSR2	20;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0021999,biological_process neural plate anterior/posterior regionalization;GO:0022407,biological_process regulation of cell-cell adhesion;GO:0048813,biological_process dendrite morphogenesis;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway	NA	cadherin EGF LAG seven-pass G-type receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:3231]
ENSG00000165695	2.75	2.33	3.02	4.85	3.69	4.21	-0.628523689228284	2.3777209815466	0.000281348235181988	0.00961866848478335	9:132725577-132878777:-	AK8	21;GO:0000166,molecular_function nucleotide binding;GO:0004017,molecular_function adenylate kinase activity;GO:0004127,molecular_function cytidylate kinase activity;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0009142,biological_process nucleoside triphosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0021591,biological_process ventricular system development;GO:0036126,cellular_component sperm flagellum	NA	adenylate kinase 8 [Source:HGNC Symbol%3BAcc:HGNC:26526]
ENSG00000185215	143.20	142.21	147.00	162.00	177.12	168.94	-0.22065250780743	8.41412093069533	0.000281954290350232	0.00961866848478335	14:103123441-103137439:+	TNFAIP2	8;GO:0000145,cellular_component exocyst;GO:0000149,molecular_function SNARE binding;GO:0001525,biological_process angiogenesis;GO:0005615,cellular_component extracellular space;GO:0006887,biological_process exocytosis;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0051601,biological_process exocyst localization	NA	TNF alpha induced protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11895]
ENSG00000185442	17.61	14.76	15.49	12.93	9.60	12.15	0.480652910776362	3.51920444056282	0.000282058755213175	0.00961866848478335	15:92617442-92809884:-	FAM174B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 174 member B [Source:HGNC Symbol%3BAcc:HGNC:34339]
ENSG00000037042	16.13	13.49	15.83	12.51	11.60	11.69	0.364369136473735	4.20957201903691	0.000283248923983673	0.00963279148879271	17:42659304-42667006:+	TUBG2	18;GO:0000166,molecular_function nucleotide binding;GO:0000242,cellular_component pericentriolar material;GO:0000930,cellular_component gamma-tubulin complex;GO:0003924,molecular_function GTPase activity;GO:0005198,molecular_function structural molecule activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0007017,biological_process microtubule-based process;GO:0007020,biological_process microtubule nucleation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0031122,biological_process cytoplasmic microtubule organization	TUBG; tubulin gamma; K10389	tubulin gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:12419]
ENSG00000007384	13.41	13.73	14.36	11.71	10.50	12.12	0.284244697504929	5.09117520860494	0.000284243970609241	0.0096392495217794	16:58058-76355:-	RHBDF1	19;GO:0000139,cellular_component Golgi membrane;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0008233,molecular_function peptidase activity;GO:0008283,biological_process cell proliferation;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0019838,molecular_function growth factor binding;GO:0042058,biological_process regulation of epidermal growth factor receptor signaling pathway;GO:0050708,biological_process regulation of protein secretion;GO:0050709,biological_process negative regulation of protein secretion;GO:0061136,biological_process regulation of proteasomal protein catabolic process	NA	rhomboid 5 homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:20561]
ENSG00000123485	68.30	68.65	63.47	78.84	81.62	76.80	-0.232286286699812	7.35708447431703	0.000284991909650611	0.0096392495217794	2:233833415-233854566:-	HJURP	17;GO:0000775,cellular_component chromosome, centromeric region;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0042393,molecular_function histone binding;GO:0042802,molecular_function identical protein binding;GO:0043254,biological_process regulation of protein complex assembly;GO:0051101,biological_process regulation of DNA binding	NA	Holliday junction recognition protein [Source:HGNC Symbol%3BAcc:HGNC:25444]
ENSG00000157800	18.40	19.85	18.25	14.61	15.89	15.95	0.28954677187593	4.84172395187451	0.000287798591202199	0.00970772802335027	7:140293692-140404433:-	SLC37A3	10;GO:0005215,molecular_function transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 37 member 3 [Source:HGNC Symbol%3BAcc:HGNC:20651]
ENSG00000146828	19.65	19.22	19.11	15.64	17.34	16.27	0.247608615052802	5.64912318918327	0.000289296756046965	0.00973181743309207	7:100826819-100867009:+	SLC12A9	14;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0015377,molecular_function cation:chloride symporter activity;GO:0015379,molecular_function potassium:chloride symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022820,molecular_function potassium ion symporter activity;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071805,biological_process potassium ion transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 12 member 9 [Source:HGNC Symbol%3BAcc:HGNC:17435]
ENSG00000065534	74.33	85.06	75.78	62.32	71.03	62.90	0.272463513793749	8.69094165314636	0.000294980025236965	0.00989618122504443	3:123610048-123884331:-	MYLK	30;GO:0000166,molecular_function nucleotide binding;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004687,molecular_function myosin light chain kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006936,biological_process muscle contraction;GO:0006939,biological_process smooth muscle contraction;GO:0014820,biological_process tonic smooth muscle contraction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030027,cellular_component lamellipodium;GO:0030335,biological_process positive regulation of cell migration;GO:0032060,biological_process bleb assembly;GO:0032154,cellular_component cleavage furrow;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0060414,biological_process aorta smooth muscle tissue morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071476,biological_process cellular hypotonic response;GO:0090303,biological_process positive regulation of wound healing	MYLK; myosin-light-chain kinase [EC:2.7.11.18]; K00907	myosin light chain kinase [Source:HGNC Symbol%3BAcc:HGNC:7590]
ENSG00000114019	34.95	39.27	34.52	26.03	33.52	27.89	0.324958261113448	6.36194404784829	0.000298799044815563	0.00997708446755245	3:134355873-134375479:-	AMOTL2	10;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005923,cellular_component bicellular tight junction;GO:0016055,biological_process Wnt signaling pathway;GO:0016324,cellular_component apical plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035329,biological_process hippo signaling;GO:0042802,molecular_function identical protein binding;GO:0055037,cellular_component recycling endosome	NA	angiomotin like 2 [Source:HGNC Symbol%3BAcc:HGNC:17812]
ENSG00000140564	10.34	12.23	10.78	8.77	9.01	8.97	0.322783246149881	4.58051855720527	0.000298999067262508	0.00997708446755245	15:90868591-90883458:+	FURIN	54;GO:0000139,cellular_component Golgi membrane;GO:0002020,molecular_function protease binding;GO:0004175,molecular_function endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008283,biological_process cell proliferation;GO:0009966,biological_process regulation of signal transduction;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016486,biological_process peptide hormone processing;GO:0016787,molecular_function hydrolase activity;GO:0019058,biological_process viral life cycle;GO:0019082,biological_process viral protein processing;GO:0022617,biological_process extracellular matrix disassembly;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0031638,biological_process zymogen activation;GO:0032455,biological_process nerve growth factor processing;GO:0032804,biological_process negative regulation of low-density lipoprotein particle receptor catabolic process;GO:0032902,biological_process nerve growth factor production;GO:0032911,biological_process negative regulation of transforming growth factor beta1 production;GO:0032940,biological_process secretion by cell;GO:0042176,biological_process regulation of protein catabolic process;GO:0042277,molecular_function peptide binding;GO:0043043,biological_process peptide biosynthetic process;GO:0044267,biological_process cellular protein metabolic process;GO:0045121,cellular_component membrane raft;GO:0045714,biological_process regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0048406,molecular_function nerve growth factor binding;GO:0051004,biological_process regulation of lipoprotein lipase activity;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0052548,biological_process regulation of endopeptidase activity;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0090472,biological_process dibasic protein processing	NA	furin%2C paired basic amino acid cleaving enzyme [Source:HGNC Symbol%3BAcc:HGNC:8568]
ENSG00000068354	9.76	8.87	8.47	6.81	6.46	7.79	0.375188105273253	4.09574544337723	0.000301935655280549	0.0100480624369905	X:48539456-48562609:+	TBC1D25	13;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0006886,biological_process intracellular protein transport;GO:0006914,biological_process autophagy;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0061024,biological_process membrane organization;GO:0090630,biological_process activation of GTPase activity;GO:1901096,biological_process regulation of autophagosome maturation	NA	TBC1 domain family member 25 [Source:HGNC Symbol%3BAcc:HGNC:8092]
ENSG00000166851	51.57	52.96	45.16	58.81	64.27	58.85	-0.270985997069504	6.73231588181369	0.00030423170654691	0.0100974015330663	16:23677655-23690367:+	PLK1	79;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000281,biological_process mitotic cytokinesis;GO:0000287,molecular_function magnesium ion binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0000795,cellular_component synaptonemal complex;GO:0000910,biological_process cytokinesis;GO:0000922,cellular_component spindle pole;GO:0000942,cellular_component condensed nuclear chromosome outer kinetochore;GO:0001578,biological_process microtubule bundle formation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0007098,biological_process centrosome cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008283,biological_process cell proliferation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010997,molecular_function anaphase-promoting complex binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016321,biological_process female meiosis chromosome segregation;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0030496,cellular_component midbody;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031648,biological_process protein destabilization;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043393,biological_process regulation of protein binding;GO:0045143,biological_process homologous chromosome segregation;GO:0045184,biological_process establishment of protein localization;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045862,biological_process positive regulation of proteolysis;GO:0051081,biological_process nuclear envelope disassembly;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0051726,biological_process regulation of cell cycle;GO:0070194,biological_process synaptonemal complex disassembly;GO:0071168,biological_process protein localization to chromatin;GO:0090435,biological_process protein localization to nuclear envelope;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1902749,biological_process regulation of cell cycle G2/M phase transition;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	PLK1; polo-like kinase 1 [EC:2.7.11.21]; K06631	polo like kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:9077]
ENSG00000158109	23.28	27.87	26.07	19.27	20.91	20.42	0.354155363875153	4.23377141813537	0.000305108128736241	0.0100994858720079	1:3625001-3630127:+	TPRG1L	10;GO:0003674,molecular_function molecular_function;GO:0008021,cellular_component synaptic vesicle;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042802,molecular_function identical protein binding;GO:0045202,cellular_component synapse;GO:0070062,cellular_component extracellular exosome	NA	tumor protein p63 regulated 1 like [Source:HGNC Symbol%3BAcc:HGNC:27007]
ENSG00000155465	90.57	90.08	89.35	105.79	117.30	100.91	-0.251127050296976	7.24825698277758	0.000309335750638397	0.0102121932783894	14:22773221-22829820:-	SLC7A7	19;GO:0000821,biological_process regulation of arginine metabolic process;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015174,molecular_function basic amino acid transmembrane transporter activity;GO:0015179,molecular_function L-amino acid transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015807,biological_process L-amino acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0050900,biological_process leukocyte migration;GO:1902475,biological_process L-alpha-amino acid transmembrane transport;GO:1990822,biological_process basic amino acid transmembrane transport	SLC7A7; solute carrier family 7 (L-type amino acid transporter), member 7; K13867	solute carrier family 7 member 7 [Source:HGNC Symbol%3BAcc:HGNC:11065]
ENSG00000065802	13.77	11.51	12.45	16.39	16.00	17.00	-0.368504056279912	3.89031920669067	0.000317633157133107	0.0104454915968674	2:238426741-238452250:+	ASB1	9;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0016567,biological_process protein ubiquitination;GO:0030539,biological_process male genitalia development;GO:0035556,biological_process intracellular signal transduction;GO:0042036,biological_process negative regulation of cytokine biosynthetic process;GO:0043687,biological_process post-translational protein modification	NA	ankyrin repeat and SOCS box containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16011]
ENSG00000138678	30.81	28.11	26.63	36.52	31.86	38.24	-0.305457297982493	5.39080508527608	0.000318085541256416	0.0104454915968674	4:83535913-83605875:+	GPAT3	16;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366,molecular_function glycerol-3-phosphate O-acyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019432,biological_process triglyceride biosynthetic process;GO:0032006,biological_process regulation of TOR signaling;GO:0102420,molecular_function sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	GPAT3_4, AGPAT9, AGPAT6; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]; K13506	glycerol-3-phosphate acyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:28157]
ENSG00000109255	14.88	17.94	15.51	21.23	24.12	21.28	-0.461134898600288	3.34469311667887	0.000321909826574902	0.0105431838450508	4:55595228-55636698:-	NMU	20;GO:0001696,biological_process gastric acid secretion;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0006940,biological_process regulation of smooth muscle contraction;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0007586,biological_process digestion;GO:0009648,biological_process photoperiodism;GO:0019233,biological_process sensory perception of pain;GO:0042755,biological_process eating behavior;GO:0042922,molecular_function neuromedin U receptor binding;GO:0043195,cellular_component terminal bouton;GO:0045187,biological_process regulation of circadian sleep/wake cycle, sleep;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046887,biological_process positive regulation of hormone secretion;GO:0050806,biological_process positive regulation of synaptic transmission;GO:2000252,biological_process negative regulation of feeding behavior;GO:2000821,biological_process regulation of grooming behavior	NMU; neuromedin U; K05249	neuromedin U [Source:HGNC Symbol%3BAcc:HGNC:7859]
ENSG00000134030	4.70	3.52	4.42	2.71	2.09	3.35	0.648875126539029	2.71843970994983	0.000325354789185277	0.0106232452288872	18:48539045-48863217:+	CTIF	8;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	cap binding complex dependent translation initiation factor [Source:HGNC Symbol%3BAcc:HGNC:23925]
ENSG00000112246	3.13	3.62	2.82	1.89	2.44	2.05	0.585936442157206	2.63157806835974	0.000326065933473458	0.0106232452288872	6:100385014-100464929:-	SIM1	13;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001657,biological_process ureteric bud development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0030154,biological_process cell differentiation;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity	NA	single-minded family bHLH transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:10882]
ENSG00000221890	16.76	15.42	14.23	13.13	12.24	11.34	0.351957250735818	4.38549449384379	0.000334546218191276	0.0108710005403359	22:38818451-38843982:-	NPTXR	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	neuronal pentraxin receptor [Source:HGNC Symbol%3BAcc:HGNC:7954]
ENSG00000189056	36.12	43.01	37.32	29.64	35.07	30.78	0.297696806985894	8.53795348286009	0.000335422253295886	0.0108710089560361	7:103471783-103989516:-	RELN	63;GO:0000904,biological_process cell morphogenesis involved in differentiation;GO:0001764,biological_process neuron migration;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0007612,biological_process learning;GO:0007616,biological_process long-term memory;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008306,biological_process associative learning;GO:0010001,biological_process glial cell differentiation;GO:0010468,biological_process regulation of gene expression;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016358,biological_process dendrite development;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021511,biological_process spinal cord patterning;GO:0021517,biological_process ventral spinal cord development;GO:0021766,biological_process hippocampus development;GO:0021800,biological_process cerebral cortex tangential migration;GO:0021819,biological_process layer formation in cerebral cortex;GO:0021987,biological_process cerebral cortex development;GO:0030425,cellular_component dendrite;GO:0030900,biological_process forebrain development;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0035418,biological_process protein localization to synapse;GO:0038026,biological_process reelin-mediated signaling pathway;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046872,molecular_function metal ion binding;GO:0048265,biological_process response to pain;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050795,biological_process regulation of behavior;GO:0050804,biological_process modulation of synaptic transmission;GO:0051057,biological_process positive regulation of small GTPase mediated signal transduction;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060291,biological_process long-term synaptic potentiation;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070325,molecular_function lipoprotein particle receptor binding;GO:0070326,molecular_function very-low-density lipoprotein particle receptor binding;GO:0090129,biological_process positive regulation of synapse maturation;GO:0097114,biological_process NMDA glutamate receptor clustering;GO:0097119,biological_process postsynaptic density protein 95 clustering;GO:0097120,biological_process receptor localization to synapse;GO:0097477,biological_process lateral motor column neuron migration;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1902078,biological_process positive regulation of lateral motor column neuron migration;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000969,biological_process positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	RELN; reelin [EC:3.4.21.-]; K06249	reelin [Source:HGNC Symbol%3BAcc:HGNC:9957]
ENSG00000152240	23.98	25.50	23.62	29.23	30.64	29.94	-0.289169004697039	4.71859520989632	0.000338755600558798	0.0109339941148449	18:46104331-46128333:+	HAUS1	18;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:25174]
ENSG00000157193	6.93	8.18	6.03	5.38	5.70	4.59	0.438246242118321	4.22614002488651	0.000339127345058833	0.0109339941148449	1:53242363-53328070:-	LRP8	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001523,biological_process retinoid metabolic process;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0008035,molecular_function high-density lipoprotein particle binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019894,molecular_function kinesin binding;GO:0021541,biological_process ammon gyrus development;GO:0021987,biological_process cerebral cortex development;GO:0030229,molecular_function very-low-density lipoprotein particle receptor activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0034185,molecular_function apolipoprotein binding;GO:0038025,molecular_function reelin receptor activity;GO:0038026,biological_process reelin-mediated signaling pathway;GO:0042493,biological_process response to drug;GO:0043025,cellular_component neuronal cell body;GO:0043235,cellular_component receptor complex;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050804,biological_process modulation of synaptic transmission;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071397,biological_process cellular response to cholesterol;GO:1900006,biological_process positive regulation of dendrite development	NA	LDL receptor related protein 8 [Source:HGNC Symbol%3BAcc:HGNC:6700]
ENSG00000164023	10.96	9.16	10.55	12.99	13.85	13.81	-0.383878013996264	3.72808537879328	0.000341050218495675	0.0109675035289814	4:107824562-107915047:+	SGMS2	20;GO:0000139,cellular_component Golgi membrane;GO:0002950,molecular_function ceramide phosphoethanolamine synthase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006686,biological_process sphingomyelin biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0033188,molecular_function sphingomyelin synthase activity;GO:0046513,biological_process ceramide biosynthetic process;GO:0047493,molecular_function ceramide cholinephosphotransferase activity;GO:1905373,biological_process ceramide phosphoethanolamine biosynthetic process	SGMS; shingomyelin synthase [EC:2.7.8.27]; K04714	sphingomyelin synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:28395]
ENSG00000119929	47.86	49.12	46.64	56.95	56.77	57.53	-0.244039492488955	5.43236177635934	0.000343010844104473	0.0110020506663277	10:99702557-99756134:+	CUTC	11;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006825,biological_process copper ion transport;GO:0046872,molecular_function metal ion binding;GO:0051262,biological_process protein tetramerization;GO:0055070,biological_process copper ion homeostasis	NA	cutC copper transporter [Source:HGNC Symbol%3BAcc:HGNC:24271]
ENSG00000111802	37.10	37.96	38.22	43.71	44.80	45.95	-0.236352320129026	5.5922300636318	0.000350553119526814	0.0112025451361792	6:24649976-24667033:-	TDP2	24;GO:0000287,molecular_function magnesium ion binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004518,molecular_function nuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016235,cellular_component aggresome;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0036317,molecular_function tyrosyl-RNA phosphodiesterase activity;GO:0046872,molecular_function metal ion binding;GO:0048666,biological_process neuron development;GO:0070260,molecular_function 5'-tyrosyl-DNA phosphodiesterase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	tyrosyl-DNA phosphodiesterase 2 [Source:HGNC Symbol%3BAcc:HGNC:17768]
ENSG00000182379	34.77	29.60	32.46	26.19	23.26	28.34	0.331023088916302	4.83634995195429	0.000351066628371361	0.0112025451361792	12:57216794-57226449:+	NXPH4	5;GO:0003674,molecular_function molecular_function;GO:0005102,molecular_function receptor binding;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0007218,biological_process neuropeptide signaling pathway	NA	neurexophilin 4 [Source:HGNC Symbol%3BAcc:HGNC:8078]
ENSG00000119280	22.53	24.06	21.98	20.15	17.24	16.77	0.349228586785694	4.33296859728071	0.000351981123585168	0.0112029274027248	1:230837118-230869589:-	C1orf198	2;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	chromosome 1 open reading frame 198 [Source:HGNC Symbol%3BAcc:HGNC:25900]
ENSG00000107521	33.55	34.04	38.06	41.34	41.98	42.97	-0.244782088657261	6.37421376653785	0.000354599905062358	0.0112574133543198	10:98416197-98446947:-	HPS1	15;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0007040,biological_process lysosome organization;GO:0007601,biological_process visual perception;GO:0031085,cellular_component BLOC-3 complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046983,molecular_function protein dimerization activity;GO:0050896,biological_process response to stimulus;GO:0061024,biological_process membrane organization;GO:1903232,biological_process melanosome assembly	NA	HPS1%2C biogenesis of lysosomal organelles complex 3 subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:5163]
ENSG00000127399	53.36	51.90	47.36	60.32	64.81	59.91	-0.266553134797123	5.4572969108295	0.000356626366223465	0.0112928650100303	7:150322638-150338150:+	LRRC61	NA	NA	leucine rich repeat containing 61 [Source:HGNC Symbol%3BAcc:HGNC:21704]
ENSG00000169297	3.18	2.45	2.14	1.66	1.42	1.37	0.824786230145959	1.6227081045903	0.000361816954882735	0.0114083905970642	X:30304205-30309598:-	NR0B1	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006694,biological_process steroid biosynthetic process;GO:0007283,biological_process spermatogenesis;GO:0007530,biological_process sex determination;GO:0008104,biological_process protein localization;GO:0008134,molecular_function transcription factor binding;GO:0008406,biological_process gonad development;GO:0008584,biological_process male gonad development;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0021854,biological_process hypothalamus development;GO:0021983,biological_process pituitary gland development;GO:0030154,biological_process cell differentiation;GO:0030238,biological_process male sex determination;GO:0030325,biological_process adrenal gland development;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032448,molecular_function DNA hairpin binding;GO:0033144,biological_process negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0033327,biological_process Leydig cell differentiation;GO:0035258,molecular_function steroid hormone receptor binding;GO:0035902,biological_process response to immobilization stress;GO:0042788,cellular_component polysomal ribosome;GO:0042803,molecular_function protein homodimerization activity;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0060008,biological_process Sertoli cell differentiation	NR0B1, DAX1; nuclear receptor subfamily 0 group B member 1; K08562	nuclear receptor subfamily 0 group B member 1 [Source:HGNC Symbol%3BAcc:HGNC:7960]
ENSG00000064687	3.44	3.30	3.77	2.85	2.85	2.79	0.324212286801861	4.37872295845598	0.00036211277654421	0.0114083905970642	19:1040100-1065572:+	ABCA7	41;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0001891,cellular_component phagocytic cup;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006909,biological_process phagocytosis;GO:0007613,biological_process memory;GO:0009986,cellular_component cell surface;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0015917,biological_process aminophospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0018149,biological_process peptide cross-linking;GO:0030054,cellular_component cell junction;GO:0031901,cellular_component early endosome membrane;GO:0032587,cellular_component ruffle membrane;GO:0033344,biological_process cholesterol efflux;GO:0033700,biological_process phospholipid efflux;GO:0034188,molecular_function apolipoprotein A-I receptor activity;GO:0034380,biological_process high-density lipoprotein particle assembly;GO:0034504,biological_process protein localization to nucleus;GO:0038027,biological_process apolipoprotein A-I-mediated signaling pathway;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042985,biological_process negative regulation of amyloid precursor protein biosynthetic process;GO:0043190,cellular_component ATP-binding cassette (ABC) transporter complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045332,biological_process phospholipid translocation;GO:0050766,biological_process positive regulation of phagocytosis;GO:0055085,biological_process transmembrane transport;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0090554,molecular_function phosphatidylcholine-translocating ATPase activity;GO:0090556,molecular_function phosphatidylserine-translocating ATPase activity;GO:1900223,biological_process positive regulation of beta-amyloid clearance;GO:1901076,biological_process positive regulation of engulfment of apoptotic cell;GO:1902430,biological_process negative regulation of beta-amyloid formation;GO:1902995,biological_process positive regulation of phospholipid efflux	ABCA7; ATP-binding cassette, subfamily A (ABC1), member 7; K05645	ATP binding cassette subfamily A member 7 [Source:HGNC Symbol%3BAcc:HGNC:37]
ENSG00000178104	3.04	2.94	2.80	2.28	2.55	2.36	0.300941748880408	4.63060691620443	0.00038141577711113	0.0119861114969126	1:148808180-149048286:+	PDE4DIP	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0019899,molecular_function enzyme binding;GO:0030016,cellular_component myofibril;GO:0043623,biological_process cellular protein complex assembly	NA	phosphodiesterase 4D interacting protein [Source:HGNC Symbol%3BAcc:HGNC:15580]
ENSG00000126790	43.39	44.44	44.53	38.38	35.34	38.61	0.247223403886717	5.45324140336418	0.000384743417915145	0.0120329511533981	14:59460362-59484430:-	L3HYPDH	4;GO:0008152,biological_process metabolic process;GO:0016829,molecular_function lyase activity;GO:0016836,molecular_function hydro-lyase activity;GO:0050346,molecular_function trans-L-3-hydroxyproline dehydratase activity	NA	trans-L-3-hydroxyproline dehydratase [Source:HGNC Symbol%3BAcc:HGNC:20488]
ENSG00000128512	2.32	1.77	2.60	1.66	1.31	1.70	0.540056764436666	3.58096554520589	0.000384845050181184	0.0120329511533981	7:111726109-112206411:-	DOCK4	22;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030165,molecular_function PDZ domain binding;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0032420,cellular_component stereocilium;GO:0032421,cellular_component stereocilium bundle;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048365,molecular_function Rac GTPase binding;GO:0060326,biological_process cell chemotaxis;GO:1904694,biological_process negative regulation of vascular smooth muscle contraction;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration	NA	dedicator of cytokinesis 4 [Source:HGNC Symbol%3BAcc:HGNC:19192]
ENSG00000197893	0.73	0.93	0.71	0.32	0.51	0.54	0.788486501700762	1.74416962009049	0.000389457545099302	0.012146574138989	10:113588715-113664127:-	NRAP	9;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005916,cellular_component fascia adherens;GO:0005927,cellular_component muscle tendon junction;GO:0008150,biological_process biological_process;GO:0017166,molecular_function vinculin binding;GO:0030016,cellular_component myofibril;GO:0046872,molecular_function metal ion binding;GO:0051371,molecular_function muscle alpha-actinin binding	NA	nebulin related anchoring protein [Source:HGNC Symbol%3BAcc:HGNC:7988]
ENSG00000165886	34.22	31.57	30.69	39.03	40.32	39.96	-0.292123949147975	4.62716373219268	0.000390629026064709	0.0121525766930858	10:97498867-97571209:+	UBTD1	2;GO:0005515,molecular_function protein binding;GO:0043130,molecular_function ubiquitin binding	NA	ubiquitin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25683]
ENSG00000096063	19.91	21.31	21.55	26.21	24.98	23.88	-0.247430472533163	5.82702997316252	0.000391611323775859	0.0121526784050743	6:35832965-35921342:-	SRPK1	31;GO:0000166,molecular_function nucleotide binding;GO:0000245,biological_process spliceosomal complex assembly;GO:0000287,molecular_function magnesium ion binding;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0007059,biological_process chromosome segregation;GO:0008380,biological_process RNA splicing;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016363,cellular_component nuclear matrix;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0035092,biological_process sperm chromatin condensation;GO:0035556,biological_process intracellular signal transduction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0050684,biological_process regulation of mRNA processing	SRPK1; serine/threonine-protein kinase SRPK1 [EC:2.7.11.1]; K15409	SRSF protein kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:11305]
ENSG00000108679	361.99	365.05	366.22	322.36	320.21	318.76	0.197277279001909	9.40453103151968	0.00039333759693511	0.0121643380763762	17:78971237-78980109:-	LGALS3BP	14;GO:0002576,biological_process platelet degranulation;GO:0005044,molecular_function scavenger receptor activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006968,biological_process cellular defense response;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0031012,cellular_component extracellular matrix;GO:0031089,cellular_component platelet dense granule lumen;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	NA	galectin 3 binding protein [Source:HGNC Symbol%3BAcc:HGNC:6564]
ENSG00000101194	34.05	33.75	32.85	27.81	28.54	29.57	0.239378580654772	5.47615886075557	0.00039394698354171	0.0121643380763762	20:62952646-62969585:+	SLC17A9	10;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0006820,biological_process anion transport;GO:0006887,biological_process exocytosis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	solute carrier family 17 member 9 [Source:HGNC Symbol%3BAcc:HGNC:16192]
ENSG00000222009	21.38	17.83	22.28	14.61	16.58	16.57	0.384763549345402	4.10988009899095	0.000401382890347077	0.0123365765213537	1:44808481-44815585:+	BTBD19	NA	NA	BTB domain containing 19 [Source:HGNC Symbol%3BAcc:HGNC:27145]
ENSG00000141837	0.77	0.61	0.69	0.55	0.35	0.41	0.689274972846466	2.18141409785341	0.000401512681432923	0.0123365765213537	19:13206441-13633025:-	CACNA1A	68;GO:0001505,biological_process regulation of neurotransmitter levels;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007214,biological_process gamma-aminobutyric acid signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0007270,biological_process neuron-neuron synaptic transmission;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0007416,biological_process synapse assembly;GO:0007628,biological_process adult walking behavior;GO:0008219,biological_process cell death;GO:0008331,molecular_function high voltage-gated calcium channel activity;GO:0010817,biological_process regulation of hormone levels;GO:0014051,biological_process gamma-aminobutyric acid secretion;GO:0014056,biological_process regulation of acetylcholine secretion, neurotransmission;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019226,biological_process transmission of nerve impulse;GO:0019905,molecular_function syntaxin binding;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021590,biological_process cerebellum maturation;GO:0021679,biological_process cerebellar molecular layer development;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0021702,biological_process cerebellar Purkinje cell differentiation;GO:0021750,biological_process vestibular nucleus development;GO:0021953,biological_process central nervous system neuron differentiation;GO:0030425,cellular_component dendrite;GO:0030644,biological_process cellular chloride ion homeostasis;GO:0031335,biological_process regulation of sulfur amino acid metabolic process;GO:0032353,biological_process negative regulation of hormone biosynthetic process;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0042391,biological_process regulation of membrane potential;GO:0042593,biological_process glucose homeostasis;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043113,biological_process receptor clustering;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0048265,biological_process response to pain;GO:0048266,biological_process behavioral response to pain;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0048813,biological_process dendrite morphogenesis;GO:0050770,biological_process regulation of axonogenesis;GO:0050796,biological_process regulation of insulin secretion;GO:0050877,biological_process neurological system process;GO:0050883,biological_process musculoskeletal movement, spinal reflex action;GO:0050885,biological_process neuromuscular process controlling balance;GO:0050905,biological_process neuromuscular process;GO:0051899,biological_process membrane depolarization;GO:0055085,biological_process transmembrane transport;GO:0060024,biological_process rhythmic synaptic transmission;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086010,biological_process membrane depolarization during action potential;GO:0098793,cellular_component presynapse	CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A; K04344	calcium voltage-gated channel subunit alpha1 A [Source:HGNC Symbol%3BAcc:HGNC:1388]
ENSG00000160285	42.00	58.28	44.70	30.65	43.46	30.77	0.477764999443381	6.67134829058483	0.000403345009522367	0.0123622755634596	21:46188140-46228824:-	LSS	12;GO:0000250,molecular_function lanosterol synthase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0016866,molecular_function intramolecular transferase activity;GO:0031647,biological_process regulation of protein stability;GO:0045540,biological_process regulation of cholesterol biosynthetic process	LSS, ERG7; lanosterol synthase [EC:5.4.99.7]; K01852	lanosterol synthase [Source:HGNC Symbol%3BAcc:HGNC:6708]
ENSG00000108556	1.15	0.97	1.29	0.25	0.67	0.52	1.25475008727926	0.425480369606598	0.00041767096740114	0.0127698268924886	17:4897773-4903074:-	CHRNE	27;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005892,cellular_component acetylcholine-gated channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006936,biological_process muscle contraction;GO:0007165,biological_process signal transduction;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015464,molecular_function acetylcholine receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022848,molecular_function acetylcholine-gated cation channel activity;GO:0030054,cellular_component cell junction;GO:0034220,biological_process ion transmembrane transport;GO:0035094,biological_process response to nicotine;GO:0042166,molecular_function acetylcholine binding;GO:0042391,biological_process regulation of membrane potential;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060079,biological_process excitatory postsynaptic potential;GO:0098655,biological_process cation transmembrane transport	CHRNE; nicotinic acetylcholine receptor epsilon; K04817	cholinergic receptor nicotinic epsilon subunit [Source:HGNC Symbol%3BAcc:HGNC:1966]
ENSG00000104177	28.62	26.68	27.38	32.16	31.57	34.79	-0.239765561884725	5.7785049557384	0.000428820663984003	0.0130785034447996	15:48134630-48178517:-	MYEF2	10;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0014902,biological_process myotube differentiation;GO:0030182,biological_process neuron differentiation	NA	myelin expression factor 2 [Source:HGNC Symbol%3BAcc:HGNC:17940]
ENSG00000082515	47.78	48.85	44.22	57.57	55.55	56.43	-0.258614229259341	5.21455016485429	0.000430968334111976	0.0131117890473823	5:154941069-154969411:+	MRPL22	11;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015934,cellular_component large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L22, MRPL22, rplV; large subunit ribosomal protein L22; K02890	mitochondrial ribosomal protein L22 [Source:HGNC Symbol%3BAcc:HGNC:14480]
ENSG00000040275	30.99	27.65	27.90	32.37	36.50	35.52	-0.256525738708593	5.87736735448473	0.000434581431448662	0.0131893870625238	5:169583633-169604778:+	SPDL1	21;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007080,biological_process mitotic metaphase plate congression;GO:0019899,molecular_function enzyme binding;GO:0031577,biological_process spindle checkpoint;GO:0034501,biological_process protein localization to kinetochore;GO:0043515,molecular_function kinetochore binding;GO:0051301,biological_process cell division	NA	spindle apparatus coiled-coil protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26010]
ENSG00000204520	40.84	52.96	37.98	29.99	38.15	30.50	0.425482776402931	5.25487935345443	0.000437055451152654	0.0132010594568443	6:31399783-31415315:+	MICA	NA	MIC; MHC class I-related protein; K07985	MHC class I polypeptide-related sequence A [Source:HGNC Symbol%3BAcc:HGNC:7090]
ENSG00000113532	2.50	3.12	2.34	1.29	1.58	1.47	0.864405646528534	1.24620102501676	0.000437842251576257	0.0132010594568443	5:100806934-100903266:-	ST8SIA4	16;GO:0000139,cellular_component Golgi membrane;GO:0001574,biological_process ganglioside biosynthetic process;GO:0003828,molecular_function alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0006491,biological_process N-glycan processing;GO:0007399,biological_process nervous system development;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0033691,molecular_function sialic acid binding;GO:0097503,biological_process sialylation	NA	ST8 alpha-N-acetyl-neuraminide alpha-2%2C8-sialyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:10871]
ENSG00000138759	0.10	0.24	0.12	0.24	0.39	0.32	-1.04886879375622	1.59276638647652	0.00043851699910698	0.0132010594568443	4:78057569-78544269:+	FRAS1	14;GO:0002009,biological_process morphogenesis of an epithelium;GO:0003338,biological_process metanephros morphogenesis;GO:0005604,cellular_component basement membrane;GO:0005886,cellular_component plasma membrane;GO:0007154,biological_process cell communication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030326,biological_process embryonic limb morphogenesis;GO:0031012,cellular_component extracellular matrix;GO:0043588,biological_process skin development;GO:0046872,molecular_function metal ion binding;GO:0060021,biological_process palate development;GO:0061618,cellular_component sublamina densa	NA	Fraser extracellular matrix complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:19185]
ENSG00000175334	490.68	477.83	424.79	553.55	589.98	533.31	-0.255874719676982	7.0966059098541	0.000439821892398165	0.0132010594568443	11:66002078-66004149:+	BANF1	22;GO:0000793,cellular_component condensed chromosome;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0008022,molecular_function protein C-terminus binding;GO:0009615,biological_process response to virus;GO:0015074,biological_process DNA integration;GO:0016032,biological_process viral process;GO:0019899,molecular_function enzyme binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045071,biological_process negative regulation of viral genome replication;GO:0047485,molecular_function protein N-terminus binding;GO:0051169,biological_process nuclear transport;GO:0070062,cellular_component extracellular exosome;GO:0075713,biological_process establishment of integrated proviral latency;GO:0097726,molecular_function LEM domain binding	NA	barrier to autointegration factor 1 [Source:HGNC Symbol%3BAcc:HGNC:17397]
ENSG00000091129	6.27	6.49	6.52	4.67	5.56	5.38	0.314907838237021	4.52181020371921	0.000440283462106946	0.0132010594568443	7:108147622-108456717:-	NRCAM	31;GO:0001525,biological_process angiogenesis;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0007413,biological_process axonal fasciculation;GO:0007416,biological_process synapse assembly;GO:0007417,biological_process central nervous system development;GO:0008104,biological_process protein localization;GO:0009897,cellular_component external side of plasma membrane;GO:0010975,biological_process regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019227,biological_process neuronal action potential propagation;GO:0030424,cellular_component axon;GO:0030506,molecular_function ankyrin binding;GO:0030516,biological_process regulation of axon extension;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043194,cellular_component axon initial segment;GO:0045162,biological_process clustering of voltage-gated sodium channels;GO:0045202,cellular_component synapse;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0086080,molecular_function protein binding involved in heterotypic cell-cell adhesion	NRCAM; neuronal cell adhesion molecule; K06756	neuronal cell adhesion molecule [Source:HGNC Symbol%3BAcc:HGNC:7994]
ENSG00000059728	1.13	1.11	1.92	3.04	2.75	3.06	-1.05474589641517	0.740430931229059	0.000450646942393259	0.0134523562642126	2:69897687-69942945:+	MXD1	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0046983,molecular_function protein dimerization activity	NA	MAX dimerization protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6761]
ENSG00000198763	4546.83	4560.18	4693.87	4059.04	3995.19	4118.81	0.192907764016214	12.1405458072159	0.000450832208645166	0.0134523562642126	MT:4469-5511:+	MT-ND2	15;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019901,molecular_function protein kinase binding;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:0072593,biological_process reactive oxygen species metabolic process	ND2; NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]; K03879	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:7456]
ENSG00000141524	0.37	0.04	0.18	0.55	0.49	0.63	-1.3752981826167	0.154861392949595	0.000470486128446657	0.0140051422359913	17:78110457-78132407:-	TMC6	16;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane	NA	transmembrane channel like 6 [Source:HGNC Symbol%3BAcc:HGNC:18021]
ENSG00000099250	67.48	66.58	70.02	58.40	60.43	59.43	0.207194670513855	7.85853688855359	0.000476349014263788	0.0141244402610914	10:33177491-33336262:-	NRP1	105;GO:0001525,biological_process angiogenesis;GO:0001569,biological_process patterning of blood vessels;GO:0001764,biological_process neuron migration;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002040,biological_process sprouting angiogenesis;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0002116,cellular_component semaphorin receptor complex;GO:0005021,molecular_function vascular endothelial growth factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005883,cellular_component neurofilament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007413,biological_process axonal fasciculation;GO:0007507,biological_process heart development;GO:0008045,biological_process motor neuron axon guidance;GO:0008201,molecular_function heparin binding;GO:0009611,biological_process response to wounding;GO:0009887,biological_process organ morphogenesis;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016358,biological_process dendrite development;GO:0016477,biological_process cell migration;GO:0017154,molecular_function semaphorin receptor activity;GO:0019838,molecular_function growth factor binding;GO:0019955,molecular_function cytokine binding;GO:0021612,biological_process facial nerve structural organization;GO:0021636,biological_process trigeminal nerve morphogenesis;GO:0021637,biological_process trigeminal nerve structural organization;GO:0021649,biological_process vestibulocochlear nerve structural organization;GO:0021675,biological_process nerve development;GO:0021785,biological_process branchiomotor neuron axon guidance;GO:0021828,biological_process gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030517,biological_process negative regulation of axon extension;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0035767,biological_process endothelial cell chemotaxis;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0036486,biological_process ventral trunk neural crest cell migration;GO:0038084,biological_process vascular endothelial growth factor signaling pathway;GO:0038085,molecular_function vascular endothelial growth factor binding;GO:0038190,biological_process VEGF-activated neuropilin signaling pathway;GO:0043025,cellular_component neuronal cell body;GO:0043235,cellular_component receptor complex;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048012,biological_process hepatocyte growth factor receptor signaling pathway;GO:0048485,biological_process sympathetic nervous system development;GO:0048666,biological_process neuron development;GO:0048841,biological_process regulation of axon extension involved in axon guidance;GO:0048842,biological_process positive regulation of axon extension involved in axon guidance;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0048844,biological_process artery morphogenesis;GO:0048846,biological_process axon extension involved in axon guidance;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050918,biological_process positive chemotaxis;GO:0060301,biological_process positive regulation of cytokine activity;GO:0060385,biological_process axonogenesis involved in innervation;GO:0060627,biological_process regulation of vesicle-mediated transport;GO:0060666,biological_process dichotomous subdivision of terminal units involved in salivary gland branching;GO:0060978,biological_process angiogenesis involved in coronary vascular morphogenesis;GO:0060982,biological_process coronary artery morphogenesis;GO:0061299,biological_process retina vasculature morphogenesis in camera-type eye;GO:0061441,biological_process renal artery morphogenesis;GO:0061549,biological_process sympathetic ganglion development;GO:0061551,biological_process trigeminal ganglion development;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0071679,biological_process commissural neuron axon guidance;GO:0090259,biological_process regulation of retinal ganglion cell axon guidance;GO:0097102,biological_process endothelial tip cell fate specification;GO:0097374,biological_process sensory neuron axon guidance;GO:0097443,cellular_component sorting endosome;GO:0097475,biological_process motor neuron migration;GO:0097490,biological_process sympathetic neuron projection extension;GO:0097491,biological_process sympathetic neuron projection guidance;GO:1901166,biological_process neural crest cell migration involved in autonomic nervous system development;GO:1901998,biological_process toxin transport;GO:1902285,biological_process semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1902287,biological_process semaphorin-plexin signaling pathway involved in axon guidance;GO:1902336,biological_process positive regulation of retinal ganglion cell axon guidance;GO:1902378,biological_process VEGF-activated neuropilin signaling pathway involved in axon guidance;GO:1902946,biological_process protein localization to early endosome;GO:1903375,biological_process facioacoustic ganglion development;GO:1904835,biological_process dorsal root ganglion morphogenesis;GO:1905040,biological_process otic placode development;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NRP1, CD304; neuropilin 1; K06724	neuropilin 1 [Source:HGNC Symbol%3BAcc:HGNC:8004]
ENSG00000111863	2.64	2.12	1.98	4.55	3.72	3.61	-0.793474701321061	1.50331946197493	0.000476769553645155	0.0141244402610914	6:11712053-11807046:-	ADTRP	4;GO:0005886,cellular_component plasma membrane;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	androgen dependent TFPI regulating protein [Source:HGNC Symbol%3BAcc:HGNC:21214]
ENSG00000115163	55.38	45.33	50.64	57.75	69.36	65.96	-0.332697378446796	4.76222381165662	0.000478154429701259	0.0141317403235279	2:26764288-26801067:+	CENPA	28;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000281,biological_process mitotic cytokinesis;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000778,cellular_component condensed nuclear chromosome kinetochore;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000786,cellular_component nucleosome;GO:0000788,cellular_component nuclear nucleosome;GO:0000939,cellular_component condensed chromosome inner kinetochore;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006334,biological_process nucleosome assembly;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0016032,biological_process viral process;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0046982,molecular_function protein heterodimerization activity;GO:0051301,biological_process cell division;GO:0051382,biological_process kinetochore assembly;GO:0071459,biological_process protein localization to chromosome, centromeric region	NA	centromere protein A [Source:HGNC Symbol%3BAcc:HGNC:1851]
ENSG00000052802	120.79	133.14	107.81	93.93	107.47	96.29	0.291088386899565	6.59658645417011	0.000481024763967467	0.014182803788903	4:165327622-165343160:+	MSMO1	16;GO:0000254,molecular_function C-4 methylsterol oxidase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	MESO1, ERG25; methylsterol monooxygenase [EC:1.14.18.9]; K07750	methylsterol monooxygenase 1 [Source:HGNC Symbol%3BAcc:HGNC:10545]
ENSG00000113916	34.65	28.70	34.96	28.03	27.14	26.86	0.276997296144162	5.99807681661087	0.00048816968464482	0.0143593608898013	3:187721376-187745727:-	BCL6	61;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000902,biological_process cell morphogenesis;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001161,molecular_function intronic transcription regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0002376,biological_process immune system process;GO:0002467,biological_process germinal center formation;GO:0002634,biological_process regulation of germinal center formation;GO:0002829,biological_process negative regulation of type 2 immune response;GO:0002903,biological_process negative regulation of B cell apoptotic process;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007266,biological_process Rho protein signal transduction;GO:0007283,biological_process spermatogenesis;GO:0008104,biological_process protein localization;GO:0008285,biological_process negative regulation of cell proliferation;GO:0030036,biological_process actin cytoskeleton organization;GO:0030183,biological_process B cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0031490,molecular_function chromatin DNA binding;GO:0032764,biological_process negative regulation of mast cell cytokine production;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0042092,biological_process type 2 immune response;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043380,biological_process regulation of memory T cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045591,biological_process positive regulation of regulatory T cell differentiation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045629,biological_process negative regulation of T-helper 2 cell differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048294,biological_process negative regulation of isotype switching to IgE isotypes;GO:0048821,biological_process erythrocyte development;GO:0050727,biological_process regulation of inflammatory response;GO:0050776,biological_process regulation of immune response;GO:0051272,biological_process positive regulation of cellular component movement;GO:1903464,biological_process negative regulation of mitotic cell cycle DNA replication;GO:2000773,biological_process negative regulation of cellular senescence	BCL6; B-cell lymphoma 6 protein; K15618	B-cell CLL/lymphoma 6 [Source:HGNC Symbol%3BAcc:HGNC:1001]
ENSG00000088826	124.43	97.58	125.77	163.40	130.38	152.54	-0.347234557758953	7.86250201541229	0.000492284826274459	0.0144461738736285	20:4120979-4187747:+	SMOX	15;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006596,biological_process polyamine biosynthetic process;GO:0006598,biological_process polyamine catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0031965,cellular_component nuclear membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046208,biological_process spermine catabolic process;GO:0046592,molecular_function polyamine oxidase activity;GO:0052894,molecular_function norspermine:oxygen oxidoreductase activity;GO:0052895,molecular_function N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity;GO:0052901,molecular_function spermine:oxygen oxidoreductase (spermidine-forming) activity;GO:0055114,biological_process oxidation-reduction process	SMOX, PAO5; spermine oxidase [EC:1.5.3.16 1.5.3.-]; K12259	spermine oxidase [Source:HGNC Symbol%3BAcc:HGNC:15862]
ENSG00000143162	49.87	50.10	52.97	41.86	44.93	41.23	0.269830563664977	4.95602973389353	0.000494175095701847	0.0144674421295921	1:167529676-167553767:-	CREG1	15;GO:0003714,molecular_function transcription corepressor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005667,cellular_component transcription factor complex;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0035578,cellular_component azurophil granule lumen;GO:0040008,biological_process regulation of growth;GO:0043312,biological_process neutrophil degranulation;GO:0048037,molecular_function cofactor binding;GO:0070062,cellular_component extracellular exosome;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	cellular repressor of E1A stimulated genes 1 [Source:HGNC Symbol%3BAcc:HGNC:2351]
ENSG00000165025	7.56	6.57	7.26	9.20	9.79	8.67	-0.349877915896661	3.98184123905231	0.000495613452493449	0.0144754112607087	9:90801786-90898549:+	SYK	93;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0001784,molecular_function phosphotyrosine binding;GO:0001820,biological_process serotonin secretion;GO:0001945,biological_process lymph vessel development;GO:0002092,biological_process positive regulation of receptor internalization;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002281,biological_process macrophage activation involved in immune response;GO:0002283,biological_process neutrophil activation involved in immune response;GO:0002366,biological_process leukocyte activation involved in immune response;GO:0002376,biological_process immune system process;GO:0002554,biological_process serotonin secretion by platelet;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0004716,molecular_function receptor signaling protein tyrosine kinase activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007167,biological_process enzyme linked receptor protein signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007257,biological_process activation of JUN kinase activity;GO:0008283,biological_process cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0010543,biological_process regulation of platelet activation;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019370,biological_process leukotriene biosynthetic process;GO:0019815,cellular_component B cell receptor complex;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0030168,biological_process platelet activation;GO:0030593,biological_process neutrophil chemotaxis;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031623,biological_process receptor internalization;GO:0032009,cellular_component early phagosome;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032928,biological_process regulation of superoxide anion generation;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0035325,molecular_function Toll-like receptor binding;GO:0035556,biological_process intracellular signal transduction;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042101,cellular_component T cell receptor complex;GO:0042169,molecular_function SH2 domain binding;GO:0042742,biological_process defense response to bacterium;GO:0042991,biological_process transcription factor import into nucleus;GO:0043234,cellular_component protein complex;GO:0043306,biological_process positive regulation of mast cell degranulation;GO:0043313,biological_process regulation of neutrophil degranulation;GO:0043366,biological_process beta selection;GO:0045087,biological_process innate immune response;GO:0045401,biological_process positive regulation of interleukin-3 biosynthetic process;GO:0045425,biological_process positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0045588,biological_process positive regulation of gamma-delta T cell differentiation;GO:0045780,biological_process positive regulation of bone resorption;GO:0046638,biological_process positive regulation of alpha-beta T cell differentiation;GO:0046641,biological_process positive regulation of alpha-beta T cell proliferation;GO:0046777,biological_process protein autophosphorylation;GO:0048514,biological_process blood vessel morphogenesis;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050764,biological_process regulation of phagocytosis;GO:0050850,biological_process positive regulation of calcium-mediated signaling;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0071226,biological_process cellular response to molecule of fungal origin;GO:0071404,biological_process cellular response to low-density lipoprotein particle stimulus;GO:0090237,biological_process regulation of arachidonic acid secretion;GO:0090330,biological_process regulation of platelet aggregation;GO:1900086,biological_process positive regulation of peptidyl-tyrosine autophosphorylation	SYK; spleen tyrosine kinase [EC:2.7.10.2]; K05855	spleen associated tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:11491]
ENSG00000060656	8.71	8.10	9.45	7.55	6.11	7.52	0.323361126698548	5.11340556390712	0.00049795102332354	0.0145095447242139	1:29236515-29326813:+	PTPRU	27;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006470,biological_process protein dephosphorylation;GO:0007155,biological_process cell adhesion;GO:0007185,biological_process transmembrane receptor protein tyrosine phosphatase signaling pathway;GO:0008013,molecular_function beta-catenin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030336,biological_process negative regulation of cell migration;GO:0031100,biological_process organ regeneration;GO:0034109,biological_process homotypic cell-cell adhesion;GO:0034394,biological_process protein localization to cell surface;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0051384,biological_process response to glucocorticoid;GO:0060070,biological_process canonical Wnt signaling pathway	NA	protein tyrosine phosphatase%2C receptor type U [Source:HGNC Symbol%3BAcc:HGNC:9683]
ENSG00000166347	6.06	6.79	4.69	3.85	2.04	2.76	1.01043567006562	0.927699536241611	0.000501586225358458	0.0145812407854205	18:74250846-74292016:-	CYB5A	20;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	cytochrome b5 type A [Source:HGNC Symbol%3BAcc:HGNC:2570]
ENSG00000139190	34.66	35.87	34.00	27.71	27.87	25.10	0.383968515152144	3.56900928056813	0.000508607813818206	0.0147206785526801	12:6462236-6470987:-	VAMP1	24;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035493,biological_process SNARE complex assembly;GO:0035579,cellular_component specific granule membrane;GO:0043005,cellular_component neuron projection;GO:0043195,cellular_component terminal bouton;GO:0045202,cellular_component synapse;GO:0070821,cellular_component tertiary granule membrane	VAMP1; vesicle-associated membrane protein 1; K08510	vesicle associated membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:12642]
ENSG00000136802	6.37	6.17	6.30	8.10	7.93	7.67	-0.316925063029863	4.1235070322704	0.000508754620083765	0.0147206785526801	9:128882111-128918039:+	LRRC8A	20;GO:0002329,biological_process pre-B cell differentiation;GO:0005225,molecular_function volume-sensitive anion channel activity;GO:0005253,molecular_function anion channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0006884,biological_process cell volume homeostasis;GO:0006970,biological_process response to osmotic stress;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0034702,cellular_component ion channel complex;GO:0044070,biological_process regulation of anion transport;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	leucine rich repeat containing 8 family member A [Source:HGNC Symbol%3BAcc:HGNC:19027]
ENSG00000198088	4.25	3.35	4.89	6.57	6.65	6.34	-0.614075312985237	2.15840419250454	0.000511311124178463	0.0147394529820614	X:107123426-107206433:-	NUP62CL	10;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005643,cellular_component nuclear pore;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0044613,cellular_component nuclear pore central transport channel;GO:0071426,biological_process ribonucleoprotein complex export from nucleus	NA	nucleoporin 62 C-terminal like [Source:HGNC Symbol%3BAcc:HGNC:25960]
ENSG00000134824	183.60	221.40	176.19	151.94	173.31	142.63	0.324039835877953	8.30141185115067	0.000511778315900143	0.0147394529820614	11:61792979-61867354:+	FADS2	15;GO:0004768,molecular_function stearoyl-CoA 9-desaturase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016213,molecular_function linoleoyl-CoA desaturase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0043651,biological_process linoleic acid metabolic process;GO:0055114,biological_process oxidation-reduction process	FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]; K10226	fatty acid desaturase 2 [Source:HGNC Symbol%3BAcc:HGNC:3575]
ENSG00000153404	2.95	2.72	2.66	2.25	1.75	2.26	0.422956866182459	3.6156442854588	0.000513048564427977	0.0147418329403807	5:92150-189972:+	PLEKHG4B	4;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	pleckstrin homology and RhoGEF domain containing G4B [Source:HGNC Symbol%3BAcc:HGNC:29399]
ENSG00000211584	16.45	18.76	19.66	13.33	12.64	13.16	0.494099766684452	2.80279623333048	0.000515572690696244	0.0147801473663106	12:47753915-47782753:+	SLC48A1	12;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015232,molecular_function heme transporter activity;GO:0015886,biological_process heme transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0020037,molecular_function heme binding	NA	solute carrier family 48 member 1 [Source:HGNC Symbol%3BAcc:HGNC:26035]
ENSG00000141012	18.38	19.26	19.19	16.14	16.43	15.42	0.254990817433404	5.07656304075352	0.000524556786866253	0.0150030492980894	16:88813733-88856970:-	GALNS	14;GO:0003824,molecular_function catalytic activity;GO:0003943,molecular_function N-acetylgalactosamine-4-sulfatase activity;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0035578,cellular_component azurophil granule lumen;GO:0042340,biological_process keratan sulfate catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043890,molecular_function N-acetylgalactosamine-6-sulfatase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	GALNS; N-acetylgalactosamine-6-sulfatase [EC:3.1.6.4]; K01132	galactosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol%3BAcc:HGNC:4122]
ENSG00000139112	70.81	72.52	71.76	84.74	82.24	85.23	-0.218973170059124	5.89075588933637	0.000530404593170591	0.0151354303793714	12:10212457-10223130:+	GABARAPL1	27;GO:0000045,biological_process autophagosome assembly;GO:0000421,cellular_component autophagosome membrane;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006914,biological_process autophagy;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030957,molecular_function Tat protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032590,cellular_component dendrite membrane;GO:0032839,cellular_component dendrite cytoplasm;GO:0044297,cellular_component cell body;GO:0048487,molecular_function beta-tubulin binding;GO:0050811,molecular_function GABA receptor binding;GO:0097352,biological_process autophagosome maturation	GABARAP, ATG8, LC3; GABA(A) receptor-associated protein; K08341	GABA type A receptor associated protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:4068]
ENSG00000205268	8.65	8.65	8.39	6.78	7.02	5.96	0.392457437767857	3.55326541949912	0.000542543768394094	0.0154463206354952	8:65717509-65842322:-	PDE7A	9;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006198,biological_process cAMP catabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	cpdP; 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]; K01120	phosphodiesterase 7A [Source:HGNC Symbol%3BAcc:HGNC:8791]
ENSG00000182272	7.71	7.61	7.87	6.44	6.19	6.56	0.285796397288069	4.48515736025867	0.000562739988351877	0.015984648685153	11:369795-382116:+	B4GALNT4	7;GO:0005794,cellular_component Golgi apparatus;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033842,molecular_function N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	B4GALNT4; beta-1,4-N-acetylgalactosaminyltransferase 4 [EC:2.4.1.244]; K09657	beta-1%2C4-N-acetyl-galactosaminyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:26315]
ENSG00000158321	5.13	3.66	5.21	3.77	3.36	3.24	0.454601195604781	4.08614981421371	0.00056439083680244	0.0159949394000655	7:69598918-70793068:+	AUTS2	10;GO:0003674,molecular_function molecular_function;GO:0003682,molecular_function chromatin binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0060013,biological_process righting reflex;GO:0098582,biological_process innate vocalization behavior;GO:2000620,biological_process positive regulation of histone H4-K16 acetylation	NA	AUTS2%2C activator of transcription and developmental regulator [Source:HGNC Symbol%3BAcc:HGNC:14262]
ENSG00000002746	7.59	8.15	7.02	8.77	10.61	8.95	-0.307842379004087	5.39341880859574	0.000573164013770598	0.0161538613176921	7:43112598-43566001:+	HECW1	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	HECT%2C C2 and WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:22195]
ENSG00000143153	264.48	273.45	276.19	222.56	249.47	231.14	0.223073653908816	7.84645706909451	0.000573443276400003	0.0161538613176921	1:169105696-169132722:+	ATP1B1	60;GO:0001666,biological_process response to hypoxia;GO:0001671,molecular_function ATPase activator activity;GO:0005391,molecular_function sodium:potassium-exchanging ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005890,cellular_component sodium:potassium-exchanging ATPase complex;GO:0005901,cellular_component caveola;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0007155,biological_process cell adhesion;GO:0008022,molecular_function protein C-terminus binding;GO:0008144,molecular_function drug binding;GO:0010107,biological_process potassium ion import;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0010468,biological_process regulation of gene expression;GO:0010882,biological_process regulation of cardiac muscle contraction by calcium ion signaling;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016887,molecular_function ATPase activity;GO:0019901,molecular_function protein kinase binding;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030001,biological_process metal ion transport;GO:0030007,biological_process cellular potassium ion homeostasis;GO:0030955,molecular_function potassium ion binding;GO:0031402,molecular_function sodium ion binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0034220,biological_process ion transmembrane transport;GO:0036376,biological_process sodium ion export from cell;GO:0042383,cellular_component sarcolemma;GO:0043209,cellular_component myelin sheath;GO:0044861,biological_process protein transport into plasma membrane raft;GO:0046034,biological_process ATP metabolic process;GO:0050821,biological_process protein stabilization;GO:0050900,biological_process leukocyte migration;GO:0051117,molecular_function ATPase binding;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060048,biological_process cardiac muscle contraction;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane;GO:0086009,biological_process membrane repolarization;GO:0086013,biological_process membrane repolarization during cardiac muscle cell action potential;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0090662,biological_process ATP hydrolysis coupled transmembrane transport;GO:1901018,biological_process positive regulation of potassium ion transmembrane transporter activity;GO:1903169,biological_process regulation of calcium ion transmembrane transport;GO:1903278,biological_process positive regulation of sodium ion export from cell;GO:1903281,biological_process positive regulation of calcium:sodium antiporter activity;GO:1903288,biological_process positive regulation of potassium ion import;GO:1903561,cellular_component extracellular vesicle;GO:1903779,biological_process regulation of cardiac conduction;GO:1990573,biological_process potassium ion import across plasma membrane	ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta; K01540	ATPase Na+/K+ transporting subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:804]
ENSG00000163110	18.57	18.57	18.05	15.05	16.84	14.91	0.250036019045585	5.53035834949587	0.000573902589309775	0.0161538613176921	4:94451856-94668227:+	PDLIM5	22;GO:0003779,molecular_function actin binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0042805,molecular_function actinin binding;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0051963,biological_process regulation of synapse assembly;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0061049,biological_process cell growth involved in cardiac muscle cell development;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	NA	PDZ and LIM domain 5 [Source:HGNC Symbol%3BAcc:HGNC:17468]
ENSG00000071282	19.87	19.80	19.58	25.66	22.95	24.10	-0.284044788524301	4.70064604971734	0.000581466343219677	0.0163297323945381	3:8501706-8574673:+	LMCD1	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0010611,biological_process regulation of cardiac muscle hypertrophy;GO:0031012,cellular_component extracellular matrix;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0070886,biological_process positive regulation of calcineurin-NFAT signaling cascade	NA	LIM and cysteine rich domains 1 [Source:HGNC Symbol%3BAcc:HGNC:6633]
ENSG00000166922	26.38	17.72	35.03	19.62	7.57	14.87	0.925563793426635	3.98379191205319	0.00058335915788235	0.0163459079611594	15:32641675-32697098:+	SCG5	12;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007218,biological_process neuropeptide signaling pathway;GO:0016486,biological_process peptide hormone processing;GO:0030141,cellular_component secretory granule;GO:0043086,biological_process negative regulation of catalytic activity;GO:0046883,biological_process regulation of hormone secretion;GO:0051082,molecular_function unfolded protein binding	NA	secretogranin V [Source:HGNC Symbol%3BAcc:HGNC:10816]
ENSG00000135905	3.23	2.96	3.47	2.61	2.38	2.75	0.335995515117651	4.28952247175082	0.000587152345851651	0.0164151397951724	2:224765089-225042445:-	DOCK10	15;GO:0001782,biological_process B cell homeostasis;GO:0002315,biological_process marginal zone B cell differentiation;GO:0003674,molecular_function molecular_function;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0030334,biological_process regulation of cell migration;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0060997,biological_process dendritic spine morphogenesis;GO:0070062,cellular_component extracellular exosome	NA	dedicator of cytokinesis 10 [Source:HGNC Symbol%3BAcc:HGNC:23479]
ENSG00000089327	103.17	105.63	118.86	96.32	85.14	94.70	0.258830121815449	6.71805434655896	0.000606442007691086	0.0169018099516211	19:35154729-35169883:+	FXYD5	14;GO:0003779,molecular_function actin binding;GO:0005216,molecular_function ion channel activity;GO:0005515,molecular_function protein binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017080,molecular_function sodium channel regulator activity;GO:0030033,biological_process microvillus assembly;GO:0034220,biological_process ion transmembrane transport;GO:0045296,molecular_function cadherin binding;GO:0046588,biological_process negative regulation of calcium-dependent cell-cell adhesion;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	NA	FXYD domain containing ion transport regulator 5 [Source:HGNC Symbol%3BAcc:HGNC:4029]
ENSG00000188610	11.08	9.89	10.94	13.37	15.19	16.43	-0.478436270687572	2.97967753646013	0.000607283270637476	0.0169018099516211	1:121167645-121185539:-	FAM72B	2;GO:0005829,cellular_component cytosol;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	family with sequence similarity 72 member B [Source:HGNC Symbol%3BAcc:HGNC:24805]
ENSG00000131584	10.70	10.46	10.83	8.49	9.10	9.08	0.274899918940242	4.64725135538472	0.000613783741498185	0.0170445136089865	1:1292375-1309609:-	ACAP3	3;GO:0005096,molecular_function GTPase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein; K12489	ArfGAP with coiled-coil%2C ankyrin repeat and PH domains 3 [Source:HGNC Symbol%3BAcc:HGNC:16754]
ENSG00000104870	35.90	31.99	35.88	31.65	25.01	27.98	0.308818974521723	5.24768078627783	0.000617627941765117	0.0170576405371667	19:49506815-49526333:+	FCGRT	8;GO:0002416,biological_process IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019770,molecular_function IgG receptor activity;GO:0019864,molecular_function IgG binding;GO:0030881,molecular_function beta-2-microglobulin binding;GO:0038094,biological_process Fc-gamma receptor signaling pathway	NA	Fc fragment of IgG receptor and transporter [Source:HGNC Symbol%3BAcc:HGNC:3621]
ENSG00000005243	20.81	19.34	21.15	16.36	15.46	16.29	0.365727727515353	3.65363632186747	0.000618873723241516	0.0170576405371667	17:48026166-48038030:-	COPZ2	18;GO:0000139,cellular_component Golgi membrane;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane	NA	coatomer protein complex subunit zeta 2 [Source:HGNC Symbol%3BAcc:HGNC:19356]
ENSG00000183023	3.95	3.54	3.65	2.97	2.21	2.98	0.46245328069438	3.3032204641969	0.000619124960939608	0.0170576405371667	2:40097269-40611053:-	SLC8A1	75;GO:0001666,biological_process response to hypoxia;GO:0002026,biological_process regulation of the force of heart contraction;GO:0002027,biological_process regulation of heart rate;GO:0002028,biological_process regulation of sodium ion transport;GO:0005432,molecular_function calcium:sodium antiporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0006936,biological_process muscle contraction;GO:0007154,biological_process cell communication;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007584,biological_process response to nutrient;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009749,biological_process response to glucose;GO:0010649,biological_process regulation of cell communication by electrical coupling;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010882,biological_process regulation of cardiac muscle contraction by calcium ion signaling;GO:0014704,cellular_component intercalated disc;GO:0014829,biological_process vascular smooth muscle contraction;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021537,biological_process telencephalon development;GO:0030018,cellular_component Z disc;GO:0030315,cellular_component T-tubule;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030506,molecular_function ankyrin binding;GO:0033198,biological_process response to ATP;GO:0035725,biological_process sodium ion transmembrane transport;GO:0035902,biological_process response to immobilization stress;GO:0035994,biological_process response to muscle stretch;GO:0042383,cellular_component sarcolemma;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0044325,molecular_function ion channel binding;GO:0044557,biological_process relaxation of smooth muscle;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0051481,biological_process negative regulation of cytosolic calcium ion concentration;GO:0051924,biological_process regulation of calcium ion transport;GO:0055013,biological_process cardiac muscle cell development;GO:0055074,biological_process calcium ion homeostasis;GO:0055085,biological_process transmembrane transport;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060048,biological_process cardiac muscle contraction;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060401,biological_process cytosolic calcium ion transport;GO:0060402,biological_process calcium ion transport into cytosol;GO:0070509,biological_process calcium ion import;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071313,biological_process cellular response to caffeine;GO:0071320,biological_process cellular response to cAMP;GO:0071436,biological_process sodium ion export;GO:0071456,biological_process cellular response to hypoxia;GO:0086012,biological_process membrane depolarization during cardiac muscle cell action potential;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0097369,biological_process sodium ion import;GO:0098735,biological_process positive regulation of the force of heart contraction;GO:0099580,molecular_function ion antiporter activity involved in regulation of postsynaptic membrane potential;GO:1903779,biological_process regulation of cardiac conduction	SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger); K05849	solute carrier family 8 member A1 [Source:HGNC Symbol%3BAcc:HGNC:11068]
ENSG00000184500	17.12	16.83	17.50	21.12	25.17	18.90	-0.328061601961334	5.37533318309133	0.00061975315252253	0.0170576405371667	3:93873032-93974066:-	PROS1	24;GO:0000139,cellular_component Golgi membrane;GO:0002576,biological_process platelet degranulation;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006465,biological_process signal peptide processing;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017187,biological_process peptidyl-glutamic acid carboxylation;GO:0030195,biological_process negative regulation of blood coagulation;GO:0030449,biological_process regulation of complement activation;GO:0031093,cellular_component platelet alpha granule lumen;GO:0042730,biological_process fibrinolysis;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	PROS1; protein S; K03908	protein S (alpha) [Source:HGNC Symbol%3BAcc:HGNC:9456]
ENSG00000139625	17.51	16.61	18.63	14.77	15.83	13.24	0.281684562311864	5.44009932911115	0.000628556390962545	0.0172616603562347	12:53479668-53500063:-	MAP3K12	29;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007254,biological_process JNK cascade;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016572,biological_process histone phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0035556,biological_process intracellular signal transduction;GO:0042803,molecular_function protein homodimerization activity;GO:0046777,biological_process protein autophosphorylation;GO:2000672,biological_process negative regulation of motor neuron apoptotic process	MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]; K04423	mitogen-activated protein kinase kinase kinase 12 [Source:HGNC Symbol%3BAcc:HGNC:6851]
ENSG00000151725	23.43	19.13	19.19	26.63	25.22	25.40	-0.305774839055952	4.87336288818511	0.000630962059571469	0.0172894747140412	4:184694617-184734133:-	CENPU	16;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007062,biological_process sister chromatid cohesion;GO:0016032,biological_process viral process;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0043009,biological_process chordate embryonic development	NA	centromere protein U [Source:HGNC Symbol%3BAcc:HGNC:21348]
ENSG00000197471	2.18	2.23	1.90	1.00	1.20	1.23	0.879122269861119	1.05589047610146	0.000634409646197659	0.0173456540490122	16:29662978-29670876:+	SPN	34;GO:0001562,biological_process response to protozoan;GO:0001808,biological_process negative regulation of type IV hypersensitivity;GO:0001931,cellular_component uropod;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006935,biological_process chemotaxis;GO:0006955,biological_process immune response;GO:0006968,biological_process cellular defense response;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030544,molecular_function Hsp70 protein binding;GO:0031072,molecular_function heat shock protein binding;GO:0031295,biological_process T cell costimulation;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042535,biological_process positive regulation of tumor necrosis factor biosynthetic process;GO:0042742,biological_process defense response to bacterium;GO:0045060,biological_process negative thymic T cell selection;GO:0050688,biological_process regulation of defense response to virus;GO:0050776,biological_process regulation of immune response;GO:0050868,biological_process negative regulation of T cell activation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0097190,biological_process apoptotic signaling pathway	SPN, CD43; sialophorin; K06477	sialophorin [Source:HGNC Symbol%3BAcc:HGNC:11249]
ENSG00000105929	3.31	3.49	3.88	5.44	4.24	5.05	-0.452112110663356	3.44304087031973	0.000642414424914971	0.0175259126515814	7:138706294-138799560:-	ATP6V0A4	34;GO:0000220,cellular_component vacuolar proton-transporting V-type ATPase, V0 domain;GO:0001503,biological_process ossification;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006885,biological_process regulation of pH;GO:0007035,biological_process vacuolar acidification;GO:0007588,biological_process excretion;GO:0007605,biological_process sensory perception of sound;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031526,cellular_component brush border membrane;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0045177,cellular_component apical part of cell;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly;GO:0090383,biological_process phagosome acidification	ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a; K02154	ATPase H+ transporting V0 subunit a4 [Source:HGNC Symbol%3BAcc:HGNC:866]
ENSG00000125384	22.56	22.25	20.49	18.26	17.87	17.35	0.298576290917236	4.41782444310135	0.000656338696175786	0.0178665180605922	14:52314304-52328606:+	PTGER2	14;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004957,molecular_function prostaglandin E receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0032570,biological_process response to progesterone;GO:0042127,biological_process regulation of cell proliferation;GO:0071380,biological_process cellular response to prostaglandin E stimulus	PTGER2; prostaglandin E receptor 2; K04259	prostaglandin E receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:9594]
ENSG00000153902	0.36	0.54	0.68	0.23	0.16	0.14	1.55826262913499	-0.27958664988195	0.00065901569253074	0.0179001352109061	19:35124512-35142451:-	LGI4	10;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0008344,biological_process adult locomotory behavior;GO:0014009,biological_process glial cell proliferation;GO:0014044,biological_process Schwann cell development;GO:0021782,biological_process glial cell development;GO:0022011,biological_process myelination in peripheral nervous system;GO:0042063,biological_process gliogenesis;GO:0042551,biological_process neuron maturation;GO:0042552,biological_process myelination	NA	leucine rich repeat LGI family member 4 [Source:HGNC Symbol%3BAcc:HGNC:18712]
ENSG00000174684	28.48	31.78	29.68	23.75	27.47	21.69	0.31257150377152	5.08121601438691	0.000661614325087667	0.0179006410044826	11:66345371-66347692:-	B4GAT1	16;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0007411,biological_process axon guidance;GO:0008532,molecular_function N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0030173,cellular_component integral component of Golgi membrane;GO:0035269,biological_process protein O-linked mannosylation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	B3GNT2; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.149]; K00741	beta-1%2C4-glucuronyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:15685]
ENSG00000140950	19.77	17.33	19.54	23.81	22.04	23.52	-0.275135070420496	4.88024687957296	0.000662343565893284	0.0179006410044826	16:84476420-84554033:-	TLDC1	3;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death	NA	TBC/LysM-associated domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29325]
ENSG00000138772	38.44	30.94	37.10	49.55	41.13	43.57	-0.316543435129537	5.29375355874089	0.000663360578591958	0.0179006410044826	4:78551518-78610451:+	ANXA3	27;GO:0004859,molecular_function phospholipase inhibitor activity;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006909,biological_process phagocytosis;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0019834,molecular_function phospholipase A2 inhibitor activity;GO:0021766,biological_process hippocampus development;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031100,biological_process organ regeneration;GO:0042581,cellular_component specific granule;GO:0042742,biological_process defense response to bacterium;GO:0043025,cellular_component neuronal cell body;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043312,biological_process neutrophil degranulation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051054,biological_process positive regulation of DNA metabolic process;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051384,biological_process response to glucocorticoid;GO:0070062,cellular_component extracellular exosome;GO:0070848,biological_process response to growth factor	NA	annexin A3 [Source:HGNC Symbol%3BAcc:HGNC:541]
ENSG00000181104	12.06	13.57	13.36	9.93	10.77	10.60	0.324071018686222	4.13652397649812	0.000674542226264323	0.0181570074122549	5:76716042-76735781:+	F2R	70;GO:0000186,biological_process activation of MAPKK activity;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0002248,biological_process connective tissue replacement involved in inflammatory response wound healing;GO:0003105,biological_process negative regulation of glomerular filtration;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005623,cellular_component cell;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0007260,biological_process tyrosine phosphorylation of STAT protein;GO:0007262,biological_process STAT protein import into nucleus;GO:0007529,biological_process establishment of synaptic specificity at neuromuscular junction;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009611,biological_process response to wounding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009986,cellular_component cell surface;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0015057,molecular_function thrombin receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030168,biological_process platelet activation;GO:0030193,biological_process regulation of blood coagulation;GO:0030194,biological_process positive regulation of blood coagulation;GO:0030335,biological_process positive regulation of cell migration;GO:0031094,cellular_component platelet dense tubular network;GO:0031594,cellular_component neuromuscular junction;GO:0031681,molecular_function G-protein beta-subunit binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0032651,biological_process regulation of interleukin-1 beta production;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045211,cellular_component postsynaptic membrane;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0051930,biological_process regulation of sensory perception of pain;GO:0060155,biological_process platelet dense granule organization;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070493,biological_process thrombin receptor signaling pathway;GO:0099553,biological_process trans-synaptic signaling by endocannabinoid, modulating synaptic transmission;GO:1900134,biological_process negative regulation of renin secretion into blood stream;GO:2000484,biological_process positive regulation of interleukin-8 secretion;GO:2000778,biological_process positive regulation of interleukin-6 secretion	F2R, PAR1; coagulation factor II (thrombin) receptor; K03914	coagulation factor II thrombin receptor [Source:HGNC Symbol%3BAcc:HGNC:3537]
ENSG00000135677	87.57	86.58	85.62	73.94	78.53	73.92	0.2102263190145	7.17115353700695	0.000675786467772639	0.0181570074122549	12:64713444-64759447:-	GNS	17;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008152,biological_process metabolic process;GO:0008449,molecular_function N-acetylglucosamine-6-sulfatase activity;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0042340,biological_process keratan sulfate catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	GNS; N-acetylglucosamine-6-sulfatase [EC:3.1.6.14]; K01137	glucosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol%3BAcc:HGNC:4422]
ENSG00000198431	199.25	196.23	195.76	176.76	171.15	173.86	0.192121367929527	8.7055745225515	0.000684403673754701	0.0183414831066931	12:104215778-104350305:+	TXNRD1	29;GO:0000305,biological_process response to oxygen radical;GO:0001650,cellular_component fibrillar center;GO:0001707,biological_process mesoderm formation;GO:0001887,biological_process selenium compound metabolic process;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007369,biological_process gastrulation;GO:0008283,biological_process cell proliferation;GO:0009055,molecular_function electron carrier activity;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016491,molecular_function oxidoreductase activity;GO:0016668,molecular_function oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor;GO:0019216,biological_process regulation of lipid metabolic process;GO:0034599,biological_process cellular response to oxidative stress;GO:0045454,biological_process cell redox homeostasis;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098625,molecular_function methylselenol reductase activity;GO:0098626,molecular_function methylseleninic acid reductase activity;GO:0098869,biological_process cellular oxidant detoxification	trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]; K00384	thioredoxin reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:12437]
ENSG00000090097	11.82	9.77	10.68	9.07	6.38	8.12	0.469704719973758	3.51734611828896	0.000686750680268942	0.0183414831066931	3:51957453-51974016:-	PCBP4	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043488,biological_process regulation of mRNA stability	PCBP2; poly(rC)-binding protein 2; K13162	poly(rC) binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:8652]
ENSG00000133640	0.33	0.37	0.28	0.40	0.74	0.72	-0.929760025441001	1.39658096241776	0.000687085285153653	0.0183414831066931	12:85036313-85263224:+	LRRIQ1	NA	NA	leucine rich repeats and IQ motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25708]
ENSG00000221869	165.23	151.58	163.07	119.13	138.06	146.30	0.262789534234636	6.89558141822326	0.000689380737048186	0.0183632684312857	8:47736908-47739086:-	CEBPD	21;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045444,biological_process fat cell differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048839,biological_process inner ear development	NA	CCAAT/enhancer binding protein delta [Source:HGNC Symbol%3BAcc:HGNC:1835]
ENSG00000162702	24.70	21.89	23.68	19.97	20.79	19.54	0.236389002540855	5.87360055372541	0.000693165517752748	0.0184022012968482	1:200404939-200410056:-	ZNF281	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010172,biological_process embryonic body morphogenesis;GO:0010629,biological_process negative regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048863,biological_process stem cell differentiation	NA	zinc finger protein 281 [Source:HGNC Symbol%3BAcc:HGNC:13075]
ENSG00000104774	37.69	36.63	37.59	32.59	31.08	33.60	0.214429736974145	6.74007074888507	0.000694256361579717	0.0184022012968482	19:12646510-12666742:-	MAN2B1	19;GO:0003824,molecular_function catalytic activity;GO:0004559,molecular_function alpha-mannosidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0006013,biological_process mannose metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0006517,biological_process protein deglycosylation;GO:0008152,biological_process metabolic process;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030246,molecular_function carbohydrate binding;GO:0035578,cellular_component azurophil granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	MAN2B1, LAMAN; lysosomal alpha-mannosidase [EC:3.2.1.24]; K12311	mannosidase alpha class 2B member 1 [Source:HGNC Symbol%3BAcc:HGNC:6826]
ENSG00000117410	60.60	64.72	59.33	52.30	54.88	51.86	0.224855010050041	5.95072524876894	0.00069528980973349	0.0184022012968482	1:43974486-43978295:+	ATP6V0B	23;GO:0000220,cellular_component vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005215,molecular_function transporter activity;GO:0005768,cellular_component endosome;GO:0005773,cellular_component vacuole;GO:0005774,cellular_component vacuolar membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007035,biological_process vacuolar acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033177,cellular_component proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0090383,biological_process phagosome acidification	ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit; K03661	ATPase H+ transporting V0 subunit b [Source:HGNC Symbol%3BAcc:HGNC:861]
ENSG00000166557	87.64	83.13	83.27	73.23	74.09	73.57	0.214542263756791	6.02767450421207	0.000697342166329118	0.0184172517247731	15:79311061-79427432:+	TMED3	17;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane	NA	transmembrane p24 trafficking protein 3 [Source:HGNC Symbol%3BAcc:HGNC:28889]
ENSG00000165795	0.72	0.63	0.70	1.80	2.10	0.82	-1.17179820468835	0.773751119387524	0.000703894518304638	0.0185508336639394	14:21016762-21070872:-	NDRG2	23;GO:0001818,biological_process negative regulation of cytokine production;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0010574,biological_process regulation of vascular endothelial growth factor production;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0021762,biological_process substantia nigra development;GO:0030154,biological_process cell differentiation;GO:0030426,cellular_component growth cone;GO:0042995,cellular_component cell projection;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0090361,biological_process regulation of platelet-derived growth factor production	NA	NDRG family member 2 [Source:HGNC Symbol%3BAcc:HGNC:14460]
ENSG00000135451	19.47	18.25	18.41	22.37	25.80	20.65	-0.280546821464296	5.8585895219162	0.000712525111671052	0.0187385046846881	12:49323235-49331731:+	TROAP	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007155,biological_process cell adhesion	NA	trophinin associated protein [Source:HGNC Symbol%3BAcc:HGNC:12327]
ENSG00000123416	1277.11	1563.27	1159.13	1656.29	1855.89	1578.09	-0.336172363931082	11.1477127908368	0.000719762642957671	0.0188541833311493	12:49127781-49131397:-	TUBA1B	22;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0003725,molecular_function double-stranded RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043209,cellular_component myelin sheath;GO:0045121,cellular_component membrane raft;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0071353,biological_process cellular response to interleukin-4	TUBA; tubulin alpha; K07374	tubulin alpha 1b [Source:HGNC Symbol%3BAcc:HGNC:18809]
ENSG00000183665	6.36	6.76	6.08	4.46	4.68	4.97	0.447752434402662	2.92101709702478	0.000719961564405444	0.0188541833311493	8:124450819-124462150:+	TRMT12	4;GO:0005515,molecular_function protein binding;GO:0008033,biological_process tRNA processing;GO:0016740,molecular_function transferase activity;GO:0102522,molecular_function tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	NA	tRNA methyltransferase 12 homolog [Source:HGNC Symbol%3BAcc:HGNC:26091]
ENSG00000131378	9.82	8.25	8.46	7.20	6.84	6.77	0.368805795421607	3.85873830361513	0.00072409752186485	0.0189225737661229	3:16313573-16514026:-	RFTN1	19;GO:0001765,biological_process membrane raft assembly;GO:0002457,biological_process T cell antigen processing and presentation;GO:0003725,molecular_function double-stranded RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0032596,biological_process protein transport into membrane raft;GO:0032620,biological_process interleukin-17 production;GO:0033227,biological_process dsRNA transport;GO:0034138,biological_process toll-like receptor 3 signaling pathway;GO:0040007,biological_process growth;GO:0043234,cellular_component protein complex;GO:0043330,biological_process response to exogenous dsRNA;GO:0045121,cellular_component membrane raft;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050853,biological_process B cell receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:1903044,biological_process protein localization to membrane raft	NA	raftlin%2C lipid raft linker 1 [Source:HGNC Symbol%3BAcc:HGNC:30278]
ENSG00000165983	22.40	17.52	21.37	24.03	26.29	27.94	-0.332204439185314	4.62318616597714	0.000730306838274045	0.0190447453434784	10:16436942-16513745:+	PTER	8;GO:0003674,molecular_function molecular_function;GO:0008270,molecular_function zinc ion binding;GO:0009056,biological_process catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0030855,biological_process epithelial cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	phosphotriesterase related [Source:HGNC Symbol%3BAcc:HGNC:9590]
ENSG00000143819	186.52	184.69	196.38	162.96	172.02	159.39	0.21137434512115	7.91844268280687	0.000733103762817444	0.0190776037900481	1:225810091-225845563:+	EPHX1	21;GO:0001889,biological_process liver development;GO:0003824,molecular_function catalytic activity;GO:0004301,molecular_function epoxide hydrolase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006725,biological_process cellular aromatic compound metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0009636,biological_process response to toxic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019439,biological_process aromatic compound catabolic process;GO:0019899,molecular_function enzyme binding;GO:0031090,cellular_component organelle membrane;GO:0033961,molecular_function cis-stilbene-oxide hydrolase activity;GO:0034312,biological_process diol biosynthetic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0071310,biological_process cellular response to organic substance;GO:0071385,biological_process cellular response to glucocorticoid stimulus	EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9]; K01253	epoxide hydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:3401]
ENSG00000198743	5.44	4.92	4.95	4.14	3.87	3.66	0.410138427804153	3.29656124639349	0.000740928605954857	0.0192408928571499	21:34073569-34106262:+	SLC5A3	15;GO:0005215,molecular_function transporter activity;GO:0005367,molecular_function myo-inositol:sodium symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006020,biological_process inositol metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0007422,biological_process peripheral nervous system development;GO:0015293,molecular_function symporter activity;GO:0015798,biological_process myo-inositol transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043576,biological_process regulation of respiratory gaseous exchange;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 5 member 3 [Source:HGNC Symbol%3BAcc:HGNC:11038]
ENSG00000188191	11.64	12.93	10.99	14.73	16.04	14.44	-0.341097424216486	4.1267603035224	0.000745398152058514	0.0193084983248175	7:549196-727650:-	PRKAR1B	20;GO:0000166,molecular_function nucleotide binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003091,biological_process renal water homeostasis;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005952,cellular_component cAMP-dependent protein kinase complex;GO:0006468,biological_process protein phosphorylation;GO:0007596,biological_process blood coagulation;GO:0007611,biological_process learning or memory;GO:0008603,molecular_function cAMP-dependent protein kinase regulator activity;GO:0016020,cellular_component membrane;GO:0030552,molecular_function cAMP binding;GO:0034199,biological_process activation of protein kinase A activity;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0045859,biological_process regulation of protein kinase activity;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0097546,cellular_component ciliary base;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity	PRKAR; cAMP-dependent protein kinase regulator; K04739	protein kinase cAMP-dependent type I regulatory subunit beta [Source:HGNC Symbol%3BAcc:HGNC:9390]
ENSG00000151693	24.48	22.10	24.12	27.70	26.56	29.43	-0.229503628958766	6.28888335338922	0.00074914814664785	0.0193084983248175	2:9206764-9405683:+	ASAP2	9;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0032580,cellular_component Golgi cisterna membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein; K12488	ArfGAP with SH3 domain%2C ankyrin repeat and PH domain 2 [Source:HGNC Symbol%3BAcc:HGNC:2721]
ENSG00000183137	13.86	13.52	14.40	17.51	17.21	16.40	-0.276170533171521	4.61522487984333	0.00074945952387042	0.0193084983248175	6:109095109-109163932:+	CEP57L1	13;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0008150,biological_process biological_process;GO:0042802,molecular_function identical protein binding;GO:0043015,molecular_function gamma-tubulin binding	NA	centrosomal protein 57 like 1 [Source:HGNC Symbol%3BAcc:HGNC:21561]
ENSG00000110025	21.11	22.54	21.60	27.51	27.59	24.87	-0.284025759186399	4.73640545398134	0.000749921657854597	0.0193084983248175	11:65027407-65040572:+	SNX15	14;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035091,molecular_function phosphatidylinositol binding	NA	sorting nexin 15 [Source:HGNC Symbol%3BAcc:HGNC:14978]
ENSG00000154814	9.76	10.12	11.11	12.92	13.46	14.06	-0.371771482581648	3.62573238572965	0.000751309489316592	0.0193084983248175	3:16265159-16350299:+	OXNAD1	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	oxidoreductase NAD binding domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25128]
ENSG00000121060	35.79	30.38	35.05	44.00	36.75	43.40	-0.280050905880579	6.19233870243502	0.000759955437583168	0.0194903447246278	17:56887908-56914038:-	TRIM25	36;GO:0002376,biological_process immune system process;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006513,biological_process protein monoubiquitination;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0019985,biological_process translesion synthesis;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0032480,biological_process negative regulation of type I interferon production;GO:0033280,biological_process response to vitamin D;GO:0036503,biological_process ERAD pathway;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043627,biological_process response to estrogen;GO:0045087,biological_process innate immune response;GO:0045296,molecular_function cadherin binding;GO:0046596,biological_process regulation of viral entry into host cell;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:1902186,biological_process regulation of viral release from host cell;GO:1902187,biological_process negative regulation of viral release from host cell;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1990830,biological_process cellular response to leukemia inhibitory factor	TRIM25, EFP; tripartite motif-containing protein 25 [EC:2.3.2.27]; K10652	tripartite motif containing 25 [Source:HGNC Symbol%3BAcc:HGNC:12932]
ENSG00000133816	69.23	57.71	68.15	90.87	69.75	84.90	-0.319412475134451	8.06661340111759	0.000771360274019401	0.0197420517142326	11:12094007-12263789:+	MICAL2	15;GO:0001947,biological_process heart looping;GO:0003779,molecular_function actin binding;GO:0004497,molecular_function monooxygenase activity;GO:0005634,cellular_component nucleus;GO:0007010,biological_process cytoskeleton organization;GO:0007507,biological_process heart development;GO:0010735,biological_process positive regulation of transcription via serum response element binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016709,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0019417,biological_process sulfur oxidation;GO:0030042,biological_process actin filament depolymerization;GO:0043914,molecular_function NADPH:sulfur oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	NA	microtubule associated monooxygenase%2C calponin and LIM domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24693]
ENSG00000109861	90.18	103.17	86.84	70.17	87.42	68.77	0.318530965828514	7.02892124999907	0.000773281065785959	0.0197504894436237	11:88293591-88337787:-	CTSC	39;GO:0000139,cellular_component Golgi membrane;GO:0001913,biological_process T cell mediated cytotoxicity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0006508,biological_process proteolysis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0007568,biological_process aging;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010033,biological_process response to organic substance;GO:0016020,cellular_component membrane;GO:0016505,molecular_function peptidase activator activity involved in apoptotic process;GO:0016787,molecular_function hydrolase activity;GO:0019902,molecular_function phosphatase binding;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0031404,molecular_function chloride ion binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035578,cellular_component azurophil granule lumen;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0043621,molecular_function protein self-association;GO:0048208,biological_process COPII vesicle coating;GO:0051087,molecular_function chaperone binding;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:1903052,biological_process positive regulation of proteolysis involved in cellular protein catabolic process;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	CTSC; cathepsin C [EC:3.4.14.1]; K01275	cathepsin C [Source:HGNC Symbol%3BAcc:HGNC:2528]
ENSG00000160190	0.57	0.60	0.41	1.59	0.81	1.19	-1.16913625711865	0.627220883475896	0.000775426540230671	0.0197646193919575	21:42496007-42581440:+	SLC37A1	13;GO:0005215,molecular_function transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015297,molecular_function antiporter activity;GO:0015760,biological_process glucose-6-phosphate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0061513,molecular_function glucose 6-phosphate:inorganic phosphate antiporter activity	NA	solute carrier family 37 member 1 [Source:HGNC Symbol%3BAcc:HGNC:11024]
ENSG00000175264	7.22	6.28	7.64	5.40	2.71	5.13	0.686937194694759	2.85213119530872	0.000785731146675963	0.0199587715801672	11:45648876-45665622:-	CHST1	15;GO:0000139,cellular_component Golgi membrane;GO:0001517,molecular_function N-acetylglucosamine 6-O-sulfotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0005976,biological_process polysaccharide metabolic process;GO:0006012,biological_process galactose metabolic process;GO:0006790,biological_process sulfur compound metabolic process;GO:0006954,biological_process inflammatory response;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0042339,biological_process keratan sulfate metabolic process;GO:0045130,molecular_function keratan sulfotransferase activity	CHST1; keratan sulfate 6-sulfotransferase 1 [EC:2.8.2.21]; K01022	carbohydrate sulfotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:1969]
ENSG00000145331	8.13	7.80	7.60	10.09	11.56	10.03	-0.414489067785713	3.25418252351837	0.000786259510408585	0.0199587715801672	4:99546708-99564032:-	TRMT10A	13;GO:0000049,molecular_function tRNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0008168,molecular_function methyltransferase activity;GO:0009019,molecular_function tRNA (guanine-N1-)-methyltransferase activity;GO:0015629,cellular_component actin cytoskeleton;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0070062,cellular_component extracellular exosome	NA	tRNA methyltransferase 10A [Source:HGNC Symbol%3BAcc:HGNC:28403]
ENSG00000140022	9.43	9.90	9.33	7.71	8.22	8.03	0.267309955536438	4.6958065935554	0.000832565078788995	0.0210910822918526	14:81260655-81436465:-	STON2	17;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030100,biological_process regulation of endocytosis;GO:0030136,cellular_component clathrin-coated vesicle;GO:0036465,biological_process synaptic vesicle recycling;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0061024,biological_process membrane organization;GO:0098793,cellular_component presynapse	NA	stonin 2 [Source:HGNC Symbol%3BAcc:HGNC:30652]
ENSG00000109066	4.59	5.49	3.95	2.94	3.55	3.33	0.516193448421537	2.90117977744375	0.000836977048556026	0.0211596661990345	17:74776482-74839779:+	TMEM104	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 104 [Source:HGNC Symbol%3BAcc:HGNC:25984]
ENSG00000133216	16.17	14.06	14.87	18.90	17.25	17.78	-0.242262664652934	5.74654182450896	0.000840645425207043	0.0212092106973476	1:22710838-22921500:+	EPHB2	71;GO:0000166,molecular_function nucleotide binding;GO:0000902,biological_process cell morphogenesis;GO:0001525,biological_process angiogenesis;GO:0001540,molecular_function beta-amyloid binding;GO:0001655,biological_process urogenital system development;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0004872,molecular_function receptor activity;GO:0005003,molecular_function ephrin receptor activity;GO:0005005,molecular_function transmembrane-ephrin receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007413,biological_process axonal fasciculation;GO:0007611,biological_process learning or memory;GO:0007612,biological_process learning;GO:0008046,molecular_function axon guidance receptor activity;GO:0009887,biological_process organ morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021631,biological_process optic nerve morphogenesis;GO:0021952,biological_process central nervous system projection neuron axonogenesis;GO:0022038,biological_process corpus callosum development;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0031915,biological_process positive regulation of synaptic plasticity;GO:0042472,biological_process inner ear morphogenesis;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0044877,molecular_function macromolecular complex binding;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048168,biological_process regulation of neuronal synaptic plasticity;GO:0048170,biological_process positive regulation of long-term neuronal synaptic plasticity;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050770,biological_process regulation of axonogenesis;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050878,biological_process regulation of body fluid levels;GO:0051389,biological_process inactivation of MAPKK activity;GO:0051965,biological_process positive regulation of synapse assembly;GO:0060021,biological_process palate development;GO:0060996,biological_process dendritic spine development;GO:0060997,biological_process dendritic spine morphogenesis;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071679,biological_process commissural neuron axon guidance;GO:0098794,cellular_component postsynapse;GO:0099557,biological_process trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;GO:0106028,biological_process neuron projection retraction;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:1904782,biological_process negative regulation of NMDA glutamate receptor activity;GO:1904783,biological_process positive regulation of NMDA glutamate receptor activity	EPHB2, ERK, DRT; Eph receptor B2 [EC:2.7.10.1]; K05111	EPH receptor B2 [Source:HGNC Symbol%3BAcc:HGNC:3393]
ENSG00000099910	7.82	7.91	7.35	5.91	6.42	6.12	0.331588309588081	3.88226119675804	0.000842522096590731	0.0212134417545248	22:20441518-20495883:-	KLHL22	18;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005827,cellular_component polar microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006513,biological_process protein monoubiquitination;GO:0007049,biological_process cell cycle;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification;GO:0051301,biological_process cell division;GO:0072686,cellular_component mitotic spindle	NA	kelch like family member 22 [Source:HGNC Symbol%3BAcc:HGNC:25888]
ENSG00000156787	9.64	9.28	10.41	11.65	11.45	12.10	-0.248193948302767	5.14439950016719	0.000853693522507507	0.0214512099086755	8:123041967-123152153:+	TBC1D31	1;GO:0005813,cellular_component centrosome	NA	TBC1 domain family member 31 [Source:HGNC Symbol%3BAcc:HGNC:30888]
ENSG00000127328	8.95	9.33	7.96	11.34	12.14	10.30	-0.355780045447473	4.03129507040161	0.000861550467779195	0.0216049009223094	12:69738680-69823204:+	RAB3IP	15;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030027,cellular_component lamellipodium;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	RAB3A interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16508]
ENSG00000152061	4.37	5.63	4.46	3.56	3.91	3.68	0.37721916470266	4.08050508310549	0.000865695882758946	0.021665086678804	1:174159409-174995308:+	RABGAP1L	14;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005929,cellular_component cilium;GO:0006886,biological_process intracellular protein transport;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0032880,biological_process regulation of protein localization;GO:0043547,biological_process positive regulation of GTPase activity;GO:0090630,biological_process activation of GTPase activity	NA	RAB GTPase activating protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:24663]
ENSG00000108960	27.99	26.10	27.94	33.66	32.50	34.57	-0.281005273620213	4.45783015814407	0.000871759564827232	0.0217729406000009	17:55392612-55421992:-	MMD	15;GO:0004672,molecular_function protein kinase activity;GO:0004872,molecular_function receptor activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019835,biological_process cytolysis;GO:0031902,cellular_component late endosome membrane;GO:0032880,biological_process regulation of protein localization;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045860,biological_process positive regulation of protein kinase activity	NA	monocyte to macrophage differentiation associated [Source:HGNC Symbol%3BAcc:HGNC:7153]
ENSG00000120820	7.52	7.43	7.15	8.47	11.53	10.51	-0.454482213311988	3.4025474922208	0.000879259915399318	0.0219161713450838	12:103988983-104064183:-	GLT8D2	6;GO:0000271,biological_process polysaccharide biosynthetic process;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	glycosyltransferase 8 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24890]
ENSG00000157399	51.51	51.17	53.41	45.83	42.61	46.75	0.219268893979081	6.52430435571249	0.000892167535814118	0.0221898895264736	X:2934631-2968310:-	ARSE	15;GO:0001501,biological_process skeletal system development;GO:0003824,molecular_function catalytic activity;GO:0004065,molecular_function arylsulfatase activity;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	arylsulfatase E (chondrodysplasia punctata 1) [Source:HGNC Symbol%3BAcc:HGNC:719]
ENSG00000128739	62.46	57.34	60.88	50.93	49.53	54.15	0.238852584111896	5.36657600436518	0.000893816544206623	0.0221898895264736	15:24823636-24978723:+	SNRPN	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005737,cellular_component cytoplasm;GO:0008380,biological_process RNA splicing;GO:0009725,biological_process response to hormone;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071004,cellular_component U2-type prespliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	small nuclear ribonucleoprotein polypeptide N [Source:HGNC Symbol%3BAcc:HGNC:11164]
ENSG00000164983	61.99	53.36	63.07	79.34	65.62	74.91	-0.285532030824972	5.58803303793692	0.000897254533352378	0.0222307794860341	8:124306188-124372692:-	TMEM65	8;GO:0003231,biological_process cardiac ventricle development;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005886,cellular_component plasma membrane;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1903779,biological_process regulation of cardiac conduction	NA	transmembrane protein 65 [Source:HGNC Symbol%3BAcc:HGNC:25203]
ENSG00000101439	466.81	462.12	450.34	396.58	401.55	414.84	0.196960691661497	7.56599891751898	0.000904274898723072	0.0223600882825687	20:23626705-23638473:-	CST3	64;GO:0001540,molecular_function beta-amyloid binding;GO:0001654,biological_process eye development;GO:0001666,biological_process response to hypoxia;GO:0001775,biological_process cell activation;GO:0002020,molecular_function protease binding;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005771,cellular_component multivesicular body;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006915,biological_process apoptotic process;GO:0006952,biological_process defense response;GO:0006979,biological_process response to oxidative stress;GO:0007420,biological_process brain development;GO:0007431,biological_process salivary gland development;GO:0007566,biological_process embryo implantation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0009636,biological_process response to toxic substance;GO:0009743,biological_process response to carbohydrate;GO:0010035,biological_process response to inorganic substance;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010711,biological_process negative regulation of collagen catabolic process;GO:0010716,biological_process negative regulation of extracellular matrix disassembly;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0014070,biological_process response to organic cyclic compound;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030424,cellular_component axon;GO:0031667,biological_process response to nutrient levels;GO:0031965,cellular_component nuclear membrane;GO:0031982,cellular_component vesicle;GO:0032355,biological_process response to estradiol;GO:0034103,biological_process regulation of tissue remodeling;GO:0034599,biological_process cellular response to oxidative stress;GO:0042493,biological_process response to drug;GO:0042747,biological_process circadian sleep/wake cycle, REM sleep;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043067,biological_process regulation of programmed cell death;GO:0043292,cellular_component contractile fiber;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045740,biological_process positive regulation of DNA replication;GO:0045861,biological_process negative regulation of proteolysis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048678,biological_process response to axon injury;GO:0060009,biological_process Sertoli cell development;GO:0060311,biological_process negative regulation of elastin catabolic process;GO:0060313,biological_process negative regulation of blood vessel remodeling;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0097435,biological_process fibril organization;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2000117,biological_process negative regulation of cysteine-type endopeptidase activity	NA	cystatin C [Source:HGNC Symbol%3BAcc:HGNC:2475]
ENSG00000117335	175.66	179.20	179.70	149.03	162.06	157.01	0.203272986013476	7.7084489611178	0.000908604355006549	0.0224224768562551	1:207752056-207795513:+	CD46	42;GO:0001618,molecular_function virus receptor activity;GO:0001669,cellular_component acrosomal vesicle;GO:0001848,molecular_function complement binding;GO:0002079,cellular_component inner acrosomal membrane;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002456,biological_process T cell mediated immunity;GO:0004175,molecular_function endopeptidase activity;GO:0004857,molecular_function enzyme inhibitor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006958,biological_process complement activation, classical pathway;GO:0007338,biological_process single fertilization;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0030449,biological_process regulation of complement activation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032613,biological_process interleukin-10 production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0035581,biological_process sequestering of extracellular ligand from receptor;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043382,biological_process positive regulation of memory T cell differentiation;GO:0045087,biological_process innate immune response;GO:0045296,molecular_function cadherin binding;GO:0045591,biological_process positive regulation of regulatory T cell differentiation;GO:0045916,biological_process negative regulation of complement activation;GO:0046718,biological_process viral entry into host cell;GO:0070062,cellular_component extracellular exosome;GO:0071636,biological_process positive regulation of transforming growth factor beta production	CD46, MCP; membrane cofactor protein; K04007	CD46 molecule [Source:HGNC Symbol%3BAcc:HGNC:6953]
ENSG00000071073	1.02	1.05	0.85	1.99	1.36	1.91	-0.843356064110113	1.33997772790379	0.000913628331056672	0.0225017231615208	2:98619105-98731126:-	MGAT4A	19;GO:0000139,cellular_component Golgi membrane;GO:0005576,cellular_component extracellular region;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006491,biological_process N-glycan processing;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0008454,molecular_function alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	MGAT4A_B; alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]; K00738	mannosyl (alpha-1%2C3-)-glycoprotein beta-1%2C4-N-acetylglucosaminyltransferase%2C isozyme A [Source:HGNC Symbol%3BAcc:HGNC:7047]
ENSG00000168528	43.89	40.95	47.73	39.05	37.26	37.15	0.239292470567982	5.93019358840931	0.000920397815800889	0.0226235605693791	1:31409564-31434680:+	SERINC2	9;GO:0006658,biological_process phosphatidylserine metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015825,biological_process L-serine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome;GO:1904219,biological_process positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:1904222,biological_process positive regulation of serine C-palmitoyltransferase activity	NA	serine incorporator 2 [Source:HGNC Symbol%3BAcc:HGNC:23231]
ENSG00000181163	930.30	936.50	898.63	1055.63	1048.39	1066.81	-0.185637004493245	9.77992306566432	0.0009240698736369	0.0226689315048515	5:171387115-171411137:+	NPM1	89;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0000056,biological_process ribosomal small subunit export from nucleus;GO:0001047,molecular_function core promoter binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001652,cellular_component granular component;GO:0003676,molecular_function nucleic acid binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006281,biological_process DNA repair;GO:0006334,biological_process nucleosome assembly;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006407,biological_process rRNA export from nucleus;GO:0006884,biological_process cell volume homeostasis;GO:0006886,biological_process intracellular protein transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006950,biological_process response to stress;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007098,biological_process centrosome cycle;GO:0007165,biological_process signal transduction;GO:0007569,biological_process cell aging;GO:0008104,biological_process protein localization;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010824,biological_process regulation of centrosome duplication;GO:0010825,biological_process positive regulation of centrosome duplication;GO:0010826,biological_process negative regulation of centrosome duplication;GO:0015934,cellular_component large ribosomal subunit;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016049,biological_process cell growth;GO:0016607,cellular_component nuclear speck;GO:0019843,molecular_function rRNA binding;GO:0019901,molecular_function protein kinase binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030957,molecular_function Tat protein binding;GO:0031328,biological_process positive regulation of cellular biosynthetic process;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031616,cellular_component spindle pole centrosome;GO:0031647,biological_process regulation of protein stability;GO:0032071,biological_process regulation of endodeoxyribonuclease activity;GO:0032993,cellular_component protein-DNA complex;GO:0033613,molecular_function activating transcription factor binding;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0034644,biological_process cellular response to UV;GO:0042255,biological_process ribosome assembly;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0042393,molecular_function histone binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043023,molecular_function ribosomal large subunit binding;GO:0043024,molecular_function ribosomal small subunit binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043516,biological_process regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044387,biological_process negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045727,biological_process positive regulation of translation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046599,biological_process regulation of centriole replication;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0050821,biological_process protein stabilization;GO:0051059,molecular_function NF-kappaB binding;GO:0051082,molecular_function unfolded protein binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051259,biological_process protein oligomerization;GO:0051260,biological_process protein homooligomerization;GO:0051726,biological_process regulation of cell cycle;GO:0060699,biological_process regulation of endoribonuclease activity;GO:0060735,biological_process regulation of eIF2 alpha phosphorylation by dsRNA;GO:1902751,biological_process positive regulation of cell cycle G2/M phase transition;GO:1904751,biological_process positive regulation of protein localization to nucleolus	NA	nucleophosmin [Source:HGNC Symbol%3BAcc:HGNC:7910]
ENSG00000167508	41.04	46.52	36.29	32.19	37.03	31.31	0.309848036143051	5.75332954028791	0.000926779148878709	0.0226905514300422	16:88651934-88663161:-	MVD	19;GO:0000166,molecular_function nucleotide binding;GO:0004163,molecular_function diphosphomevalonate decarboxylase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006489,biological_process dolichyl diphosphate biosynthetic process;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016126,biological_process sterol biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0019287,biological_process isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0030544,molecular_function Hsp70 protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045540,biological_process regulation of cholesterol biosynthetic process	MVD, mvaD; diphosphomevalonate decarboxylase [EC:4.1.1.33]; K01597	mevalonate diphosphate decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:7529]
ENSG00000173237	11.26	4.43	6.83	16.93	10.77	15.08	-0.883669111447252	1.99664835885642	0.000931563522560667	0.0227627913494991	11:66975276-66977004:+	C11orf86	NA	NA	chromosome 11 open reading frame 86 [Source:HGNC Symbol%3BAcc:HGNC:34442]
ENSG00000163513	80.81	84.48	78.45	71.20	70.72	70.99	0.205767314280075	7.08047263748372	0.000937247582571911	0.0228566880991456	3:30606501-30694142:+	TGFBR2	115;GO:0000166,molecular_function nucleotide binding;GO:0001568,biological_process blood vessel development;GO:0001569,biological_process patterning of blood vessels;GO:0001570,biological_process vasculogenesis;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001947,biological_process heart looping;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002088,biological_process lens development in camera-type eye;GO:0002651,biological_process positive regulation of tolerance induction to self antigen;GO:0002663,biological_process positive regulation of B cell tolerance induction;GO:0002666,biological_process positive regulation of T cell tolerance induction;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003149,biological_process membranous septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003186,biological_process tricuspid valve morphogenesis;GO:0003214,biological_process cardiac left ventricle morphogenesis;GO:0003274,biological_process endocardial cushion fusion;GO:0003417,biological_process growth plate cartilage development;GO:0003430,biological_process growth plate cartilage chondrocyte growth;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0004872,molecular_function receptor activity;GO:0005024,molecular_function transforming growth factor beta-activated receptor activity;GO:0005026,molecular_function transforming growth factor beta receptor activity, type II;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0006468,biological_process protein phosphorylation;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006915,biological_process apoptotic process;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007182,biological_process common-partner SMAD protein phosphorylation;GO:0007219,biological_process Notch signaling pathway;GO:0007224,biological_process smoothened signaling pathway;GO:0007369,biological_process gastrulation;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007566,biological_process embryo implantation;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009612,biological_process response to mechanical stimulus;GO:0009749,biological_process response to glucose;GO:0009887,biological_process organ morphogenesis;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0010468,biological_process regulation of gene expression;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031100,biological_process organ regeneration;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0032147,biological_process activation of protein kinase activity;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0035162,biological_process embryonic hemopoiesis;GO:0040008,biological_process regulation of growth;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0043235,cellular_component receptor complex;GO:0043415,biological_process positive regulation of skeletal muscle tissue regeneration;GO:0043627,biological_process response to estrogen;GO:0045121,cellular_component membrane raft;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0048545,biological_process response to steroid hormone;GO:0048565,biological_process digestive tract development;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0050431,molecular_function transforming growth factor beta binding;GO:0051138,biological_process positive regulation of NK T cell differentiation;GO:0051216,biological_process cartilage development;GO:0060021,biological_process palate development;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060425,biological_process lung morphogenesis;GO:0060433,biological_process bronchus development;GO:0060434,biological_process bronchus morphogenesis;GO:0060439,biological_process trachea morphogenesis;GO:0060440,biological_process trachea formation;GO:0060443,biological_process mammary gland morphogenesis;GO:0060463,biological_process lung lobe morphogenesis;GO:0070022,cellular_component transforming growth factor beta receptor homodimeric complex;GO:0070723,biological_process response to cholesterol;GO:1905007,biological_process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:1905317,biological_process inferior endocardial cushion morphogenesis;GO:1990086,biological_process lens fiber cell apoptotic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2000563,biological_process positive regulation of CD4-positive, alpha-beta T cell proliferation	TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]; K04388	transforming growth factor beta receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:11773]
ENSG00000166997	26.93	33.51	26.79	19.47	25.28	22.03	0.389856619418077	4.26881873663014	0.000943048545840382	0.0229530619598366	7:100119612-100125511:+	CNPY4	2;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region	NA	canopy FGF signaling regulator 4 [Source:HGNC Symbol%3BAcc:HGNC:28631]
ENSG00000162897	1.30	1.04	0.52	1.67	2.39	1.57	-0.958378848552364	1.47120095817217	0.000953323708266317	0.0231577440131307	1:206957964-206970625:-	FCAMR	10;GO:0001791,molecular_function IgM binding;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019862,molecular_function IgA binding;GO:0050900,biological_process leukocyte migration	NA	Fc fragment of IgA and IgM receptor [Source:HGNC Symbol%3BAcc:HGNC:24692]
ENSG00000159348	31.02	29.89	33.44	26.62	27.18	25.67	0.263015415387789	4.93698922775866	0.000976007086768191	0.0236624530626046	1:202961868-202967280:-	CYB5R1	20;GO:0002576,biological_process platelet degranulation;GO:0003674,molecular_function molecular_function;GO:0004128,molecular_function cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0008150,biological_process biological_process;GO:0008202,biological_process steroid metabolic process;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0031092,cellular_component platelet alpha granule membrane;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	E1.6.2.2; cytochrome-b5 reductase [EC:1.6.2.2]; K00326	cytochrome b5 reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:13397]
ENSG00000054967	6.30	6.74	5.59	4.64	3.47	4.91	0.518320534112214	2.78959884852111	0.000978903913566932	0.0236864215966985	11:73376263-73397474:+	RELT	15;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0070062,cellular_component extracellular exosome;GO:0097190,biological_process apoptotic signaling pathway	TNFRSF19L, RELT; tumor necrosis factor receptor superfamily member 19-like; K05156	RELT%2C TNF receptor [Source:HGNC Symbol%3BAcc:HGNC:13764]
ENSG00000141458	146.65	143.71	145.91	128.62	128.49	130.30	0.183222344386238	9.12227505966427	0.000981399027802496	0.0237005955877673	18:23506183-23586898:-	NPC1	49;GO:0001618,molecular_function virus receptor activity;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005319,molecular_function lipid transporter activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005635,cellular_component nuclear envelope;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0006629,biological_process lipid metabolic process;GO:0006869,biological_process lipid transport;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0007041,biological_process lysosomal transport;GO:0007165,biological_process signal transduction;GO:0007628,biological_process adult walking behavior;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008206,biological_process bile acid metabolic process;GO:0015248,molecular_function sterol transporter activity;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016242,biological_process negative regulation of macroautophagy;GO:0030301,biological_process cholesterol transport;GO:0031579,biological_process membrane raft organization;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0033344,biological_process cholesterol efflux;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0042493,biological_process response to drug;GO:0042632,biological_process cholesterol homeostasis;GO:0045121,cellular_component membrane raft;GO:0046686,biological_process response to cadmium ion;GO:0046718,biological_process viral entry into host cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0071404,biological_process cellular response to low-density lipoprotein particle stimulus;GO:0090150,biological_process establishment of protein localization to membrane;GO:2000189,biological_process positive regulation of cholesterol homeostasis	NPC1; Niemann-Pick C1 protein; K12385	NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol%3BAcc:HGNC:7897]
ENSG00000118515	6.78	8.56	6.86	4.24	6.66	4.69	0.516725744119582	3.78693609264771	0.000989950523102545	0.0238606909578095	6:134169245-134318112:-	SGK1	43;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005246,molecular_function calcium channel regulator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006814,biological_process sodium ion transport;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007616,biological_process long-term memory;GO:0008217,biological_process regulation of blood pressure;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0017080,molecular_function sodium channel regulator activity;GO:0017081,molecular_function chloride channel regulator activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030334,biological_process regulation of cell migration;GO:0032411,biological_process positive regulation of transporter activity;GO:0034220,biological_process ion transmembrane transport;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035556,biological_process intracellular signal transduction;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0048812,biological_process neuron projection morphogenesis;GO:0050790,biological_process regulation of catalytic activity;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0060453,biological_process regulation of gastric acid secretion;GO:0070294,biological_process renal sodium ion absorption	SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]; K13302	serum/glucocorticoid regulated kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:10810]
ENSG00000142871	148.98	165.21	127.11	102.51	137.35	104.28	0.369829474396394	7.22584700080968	0.00102365511731593	0.0246252538202376	1:85580760-85583962:+	CYR61	49;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0001649,biological_process osteoblast differentiation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002041,biological_process intussusceptive angiogenesis;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003278,biological_process apoptotic process involved in heart morphogenesis;GO:0003281,biological_process ventricular septum development;GO:0005178,molecular_function integrin binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0007267,biological_process cell-cell signaling;GO:0008201,molecular_function heparin binding;GO:0008283,biological_process cell proliferation;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010518,biological_process positive regulation of phospholipase activity;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019838,molecular_function growth factor binding;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0031012,cellular_component extracellular matrix;GO:0033690,biological_process positive regulation of osteoblast proliferation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0044319,biological_process wound healing, spreading of cells;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050840,molecular_function extracellular matrix binding;GO:0060413,biological_process atrial septum morphogenesis;GO:0060548,biological_process negative regulation of cell death;GO:0060591,biological_process chondroblast differentiation;GO:0060710,biological_process chorio-allantoic fusion;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0061036,biological_process positive regulation of cartilage development;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0072593,biological_process reactive oxygen species metabolic process;GO:2000304,biological_process positive regulation of ceramide biosynthetic process	NA	cysteine rich angiogenic inducer 61 [Source:HGNC Symbol%3BAcc:HGNC:2654]
ENSG00000100253	5.02	3.34	3.40	7.51	6.58	5.15	-0.681060792983212	2.25739257461544	0.00102625504326627	0.0246400461355207	22:50486783-50490648:+	MIOX	15;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005506,molecular_function iron ion binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008199,molecular_function ferric iron binding;GO:0016234,cellular_component inclusion body;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0016701,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0019310,biological_process inositol catabolic process;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050113,molecular_function inositol oxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	MIOX; inositol oxygenase [EC:1.13.99.1]; K00469	myo-inositol oxygenase [Source:HGNC Symbol%3BAcc:HGNC:14522]
ENSG00000130518	0.33	0.47	0.34	0.15	0.11	0.24	1.15312227322082	0.31317255322416	0.00104009815076242	0.0249242053000269	19:18257096-18274509:-	KIAA1683	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion	NA	KIAA1683 [Source:HGNC Symbol%3BAcc:HGNC:29350]
ENSG00000121988	3.98	4.49	4.03	5.40	5.08	5.18	-0.321141054193576	4.04901041008304	0.00105155790421666	0.0251502664066309	2:135136915-135531236:-	ZRANB3	26;GO:0000166,molecular_function nucleotide binding;GO:0000733,biological_process DNA strand renaturation;GO:0003676,molecular_function nucleic acid binding;GO:0003824,molecular_function catalytic activity;GO:0004386,molecular_function helicase activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0009411,biological_process response to UV;GO:0016787,molecular_function hydrolase activity;GO:0031297,biological_process replication fork processing;GO:0036292,biological_process DNA rewinding;GO:0036310,molecular_function annealing helicase activity;GO:0043596,cellular_component nuclear replication fork;GO:0045910,biological_process negative regulation of DNA recombination;GO:0046872,molecular_function metal ion binding;GO:0048478,biological_process replication fork protection;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	zinc finger RANBP2-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25249]
ENSG00000146278	72.64	72.87	80.88	93.72	85.12	88.95	-0.229607369959194	6.34101901196535	0.0010553161365608	0.0251916138521716	6:89080750-89085160:+	PNRC1	7;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031087,biological_process deadenylation-independent decapping of nuclear-transcribed mRNA	NA	proline rich nuclear receptor coactivator 1 [Source:HGNC Symbol%3BAcc:HGNC:17278]
ENSG00000107036	11.99	12.77	13.56	10.93	11.09	10.90	0.230111706420791	5.69180403779011	0.00107329931992487	0.025525552835815	9:5629024-5776557:+	RIC1	17;GO:0000139,cellular_component Golgi membrane;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034066,cellular_component RIC1-RGP1 guanyl-nucleotide exchange factor complex;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization;GO:1903363,biological_process negative regulation of cellular protein catabolic process	NA	RIC1 homolog%2C RAB6A GEF complex partner 1 [Source:HGNC Symbol%3BAcc:HGNC:17686]
ENSG00000102189	12.63	14.36	13.52	9.82	12.90	9.76	0.329573654234231	5.69194540360351	0.00107341807623422	0.025525552835815	12:92770636-92929331:-	EEA1	26;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005969,cellular_component serine-pyruvate aminotransferase complex;GO:0006897,biological_process endocytosis;GO:0006906,biological_process vesicle fusion;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016189,biological_process synaptic vesicle to endosome fusion;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0039694,biological_process viral RNA genome replication;GO:0042803,molecular_function protein homodimerization activity;GO:0044308,cellular_component axonal spine;GO:0045022,biological_process early endosome to late endosome transport;GO:0046872,molecular_function metal ion binding;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:0098793,cellular_component presynapse	EEA1; early endosome antigen 1; K12478	early endosome antigen 1 [Source:HGNC Symbol%3BAcc:HGNC:3185]
ENSG00000123131	159.78	153.24	152.63	137.00	133.86	138.85	0.196620592376227	7.380024935611	0.00107958776678541	0.0256231796350044	X:23664261-23686399:+	PRDX4	31;GO:0004601,molecular_function peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007252,biological_process I-kappaB phosphorylation;GO:0007283,biological_process spermatogenesis;GO:0008379,molecular_function thioredoxin peroxidase activity;GO:0008584,biological_process male gonad development;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019471,biological_process 4-hydroxyproline metabolic process;GO:0022417,biological_process protein maturation by protein folding;GO:0030198,biological_process extracellular matrix organization;GO:0034774,cellular_component secretory granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0045454,biological_process cell redox homeostasis;GO:0051920,molecular_function peroxiredoxin activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0098869,biological_process cellular oxidant detoxification;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2000255,biological_process negative regulation of male germ cell proliferation	PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]; K03386	peroxiredoxin 4 [Source:HGNC Symbol%3BAcc:HGNC:17169]
ENSG00000133433	4.73	3.92	4.52	2.76	2.69	2.59	0.731974730528104	1.45246260225124	0.00108910013779428	0.0257944398925307	22:23957413-23961186:-	GSTT2B	8;GO:0004364,molecular_function glutathione transferase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0016740,molecular_function transferase activity;GO:0070062,cellular_component extracellular exosome;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase theta 2B (gene/pseudogene) [Source:HGNC Symbol%3BAcc:HGNC:33437]
ENSG00000153071	74.99	85.67	73.22	56.80	73.79	59.38	0.311146085980916	7.36254575596508	0.001090959553982	0.0257944398925307	5:39371674-39462300:-	DAB2	49;GO:0001650,cellular_component fibrillar center;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030154,biological_process cell differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032091,biological_process negative regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035026,biological_process leading edge cell differentiation;GO:0035615,molecular_function clathrin adaptor activity;GO:0038024,molecular_function cargo receptor activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045807,biological_process positive regulation of endocytosis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046332,molecular_function SMAD binding;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0061024,biological_process membrane organization;GO:0070022,cellular_component transforming growth factor beta receptor homodimeric complex;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1903077,biological_process negative regulation of protein localization to plasma membrane;GO:2000096,biological_process positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:2000370,biological_process positive regulation of clathrin-mediated endocytosis;GO:2000643,biological_process positive regulation of early endosome to late endosome transport	DAB2; disabled homolog 2; K12475	DAB2%2C clathrin adaptor protein [Source:HGNC Symbol%3BAcc:HGNC:2662]
ENSG00000196502	4.74	5.24	5.08	6.73	7.96	6.65	-0.493112646639101	2.71898280855732	0.0011030309389839	0.0260302719498235	16:28605195-28623625:-	SULT1A1	19;GO:0004062,molecular_function aryl sulfotransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006068,biological_process ethanol catabolic process;GO:0006584,biological_process catecholamine metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0008146,molecular_function sulfotransferase activity;GO:0008202,biological_process steroid metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0009308,biological_process amine metabolic process;GO:0009812,biological_process flavonoid metabolic process;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0047894,molecular_function flavonol 3-sulfotransferase activity;GO:0050294,molecular_function steroid sulfotransferase activity;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0051923,biological_process sulfation	SULT1A; aryl sulfotransferase [EC:2.8.2.1]; K01014	sulfotransferase family 1A member 1 [Source:HGNC Symbol%3BAcc:HGNC:11453]
ENSG00000159433	2.78	2.62	2.98	2.32	2.46	2.35	0.249479501104639	5.19779099173449	0.00110598319659362	0.0260504163554395	15:42575658-42720981:+	STARD9	13;GO:0000166,molecular_function nucleotide binding;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008152,biological_process metabolic process;GO:0008289,molecular_function lipid binding;GO:0015485,molecular_function cholesterol binding;GO:0051225,biological_process spindle assembly	NA	StAR related lipid transfer domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:19162]
ENSG00000135404	986.39	954.32	902.36	813.02	850.28	837.33	0.196901531468978	9.31617479973525	0.0011215183262724	0.026366301106097	12:55725322-55729707:-	CD63	38;GO:0002092,biological_process positive regulation of receptor internalization;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0007160,biological_process cell-matrix adhesion;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0031088,cellular_component platelet dense granule membrane;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031902,cellular_component late endosome membrane;GO:0031904,cellular_component endosome lumen;GO:0032585,cellular_component multivesicular body membrane;GO:0034613,biological_process cellular protein localization;GO:0035577,cellular_component azurophil granule membrane;GO:0035646,biological_process endosome to melanosome transport;GO:0042470,cellular_component melanosome;GO:0043312,biological_process neutrophil degranulation;GO:0043473,biological_process pigmentation;GO:0048757,biological_process pigment granule maturation;GO:0050931,biological_process pigment cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0097487,cellular_component multivesicular body, internal vesicle;GO:1900746,biological_process regulation of vascular endothelial growth factor signaling pathway;GO:2000680,biological_process regulation of rubidium ion transport;GO:2001046,biological_process positive regulation of integrin-mediated signaling pathway	NA	CD63 molecule [Source:HGNC Symbol%3BAcc:HGNC:1692]
ENSG00000141664	5.15	5.26	5.44	4.26	4.22	4.57	0.291797107353894	4.24974593557337	0.00112694017284482	0.026443683110629	18:62523006-62587709:+	ZCCHC2	5;GO:0003676,molecular_function nucleic acid binding;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 2 [Source:HGNC Symbol%3BAcc:HGNC:22916]
ENSG00000198369	8.73	8.69	9.04	11.28	10.25	12.27	-0.341983236444169	3.90741752350047	0.00113265863214414	0.0264815525680887	2:65310850-65432637:-	SPRED2	17;GO:0000188,biological_process inactivation of MAPK activity;GO:0005173,molecular_function stem cell factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009966,biological_process regulation of signal transduction;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0030658,cellular_component transport vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0090311,biological_process regulation of protein deacetylation	NA	sprouty related EVH1 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:17722]
ENSG00000110104	64.48	61.59	61.33	75.15	69.80	73.70	-0.210159355470254	6.19652973394497	0.0011328207857613	0.0264815525680887	11:60842070-60851081:+	CCDC86	5;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0016032,biological_process viral process	NA	coiled-coil domain containing 86 [Source:HGNC Symbol%3BAcc:HGNC:28359]
ENSG00000086300	38.85	37.89	38.97	46.22	43.07	51.41	-0.270617752206629	4.97220540239028	0.00114845360980752	0.0267965313130465	7:26291894-26374329:+	SNX10	25;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0007032,biological_process endosome organization;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0030316,biological_process osteoclast differentiation;GO:0031313,cellular_component extrinsic component of endosome membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0051117,molecular_function ATPase binding;GO:0060271,biological_process cilium morphogenesis;GO:0061512,biological_process protein localization to cilium;GO:0071539,biological_process protein localization to centrosome;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	sorting nexin 10 [Source:HGNC Symbol%3BAcc:HGNC:14974]
ENSG00000113194	29.40	31.50	32.18	37.60	36.16	36.11	-0.228944387065365	5.50651437833487	0.00116711026965403	0.0271807500510609	5:176447627-176510074:+	FAF2	17;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005811,cellular_component lipid particle;GO:0006986,biological_process response to unfolded protein;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0034389,biological_process lipid particle organization;GO:0035473,molecular_function lipase binding;GO:0035578,cellular_component azurophil granule lumen;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043130,molecular_function ubiquitin binding;GO:0043312,biological_process neutrophil degranulation;GO:0055102,molecular_function lipase inhibitor activity	NA	Fas associated factor family member 2 [Source:HGNC Symbol%3BAcc:HGNC:24666]
ENSG00000104537	4.95	6.25	4.19	2.10	4.18	2.69	0.78026012519408	2.14436461383105	0.00118345855593527	0.0274772207309508	8:123680793-123737407:-	ANXA13	8;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0070062,cellular_component extracellular exosome	NA	annexin A13 [Source:HGNC Symbol%3BAcc:HGNC:536]
ENSG00000163697	34.97	29.66	36.22	44.77	36.79	42.35	-0.282756765748952	6.42733637844003	0.00118426754942872	0.0274772207309508	4:40810026-41216714:-	APBB2	18;GO:0001540,molecular_function beta-amyloid binding;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007050,biological_process cell cycle arrest;GO:0007411,biological_process axon guidance;GO:0008134,molecular_function transcription factor binding;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030198,biological_process extracellular matrix organization;GO:0030308,biological_process negative regulation of cell growth;GO:0030426,cellular_component growth cone;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045202,cellular_component synapse	NA	amyloid beta precursor protein binding family B member 2 [Source:HGNC Symbol%3BAcc:HGNC:582]
ENSG00000164674	40.21	32.12	35.96	46.93	40.49	44.53	-0.270061945869788	6.20190023030874	0.00120142714700055	0.0278059141215104	6:158650013-158764876:+	SYTL3	18;GO:0005509,molecular_function calcium ion binding;GO:0005543,molecular_function phospholipid binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0019905,molecular_function syntaxin binding;GO:0030276,molecular_function clathrin binding;GO:0042043,molecular_function neurexin family protein binding;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0070382,cellular_component exocytic vesicle;GO:0098793,cellular_component presynapse	NA	synaptotagmin like 3 [Source:HGNC Symbol%3BAcc:HGNC:15587]
ENSG00000110871	25.99	23.24	24.02	30.12	29.01	29.06	-0.251364171301959	4.9066853713955	0.00120425308300764	0.0278059141215104	12:120503273-120534434:-	COQ5	13;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0031314,cellular_component extrinsic component of mitochondrial inner membrane;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex;GO:0043430,molecular_function 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity;GO:0102005,molecular_function 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity	COQ5; 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.201]; K06127	coenzyme Q5%2C methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:28722]
ENSG00000130768	1.54	2.21	2.12	3.51	2.46	3.38	-0.675711177141094	2.0801585004024	0.00120616014275074	0.0278059141215104	1:27934992-27959157:+	SMPDL3B	23;GO:0002376,biological_process immune system process;GO:0003674,molecular_function molecular_function;GO:0004767,molecular_function sphingomyelin phosphodiesterase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006685,biological_process sphingomyelin catabolic process;GO:0006954,biological_process inflammatory response;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0031225,cellular_component anchored component of membrane;GO:0034122,biological_process negative regulation of toll-like receptor signaling pathway;GO:0045087,biological_process innate immune response;GO:0046466,biological_process membrane lipid catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0070062,cellular_component extracellular exosome	NA	sphingomyelin phosphodiesterase acid like 3B [Source:HGNC Symbol%3BAcc:HGNC:21416]
ENSG00000106003	34.87	34.67	34.62	40.38	39.44	41.41	-0.207516756158294	5.77335835402696	0.00120755544561672	0.0278059141215104	7:2512528-2529177:+	LFNG	26;GO:0000139,cellular_component Golgi membrane;GO:0001541,biological_process ovarian follicle development;GO:0001756,biological_process somitogenesis;GO:0002315,biological_process marginal zone B cell differentiation;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0007275,biological_process multicellular organism development;GO:0007386,biological_process compartment pattern specification;GO:0007389,biological_process pattern specification process;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0009887,biological_process organ morphogenesis;GO:0014807,biological_process regulation of somitogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030217,biological_process T cell differentiation;GO:0032092,biological_process positive regulation of protein binding;GO:0033829,molecular_function O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0051446,biological_process positive regulation of meiotic cell cycle;GO:1902367,biological_process negative regulation of Notch signaling pathway involved in somitogenesis;GO:1903561,cellular_component extracellular vesicle	FNG; fringe [EC:2.4.1.222]; K05948	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:HGNC Symbol%3BAcc:HGNC:6560]
ENSG00000067167	358.71	412.22	354.54	300.49	343.65	310.50	0.248877699461674	8.61000291373594	0.00120963454649284	0.0278059141215104	8:70573441-70608387:-	TRAM1	10;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process	TRAM1; translocating chain-associated membrane protein 1; K14010	translocation associated membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20568]
ENSG00000145428	2.83	2.52	2.30	1.46	1.55	1.37	0.813071458868556	1.13266415817243	0.00123136208667278	0.028253045437836	4:153710124-153760235:-	RNF175	10;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 175 [Source:HGNC Symbol%3BAcc:HGNC:27735]
ENSG00000138780	9.47	8.13	9.33	10.65	11.92	11.13	-0.303664368793801	4.31063752069159	0.00124065314329456	0.0284137038149729	4:105708777-105847728:+	GSTCD	5;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome	NA	glutathione S-transferase C-terminal domain containing [Source:HGNC Symbol%3BAcc:HGNC:25806]
ENSG00000214274	12.65	16.69	12.18	6.96	9.97	10.05	0.615726743474056	2.35551079858726	0.00124718397107909	0.0284897513923381	14:20684176-20698971:+	ANG	49;GO:0001525,biological_process angiogenesis;GO:0001541,biological_process ovarian follicle development;GO:0001556,biological_process oocyte maturation;GO:0001666,biological_process response to hypoxia;GO:0001890,biological_process placenta development;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003779,molecular_function actin binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0005102,molecular_function receptor binding;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005605,cellular_component basal lamina;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006651,biological_process diacylglycerol biosynthetic process;GO:0007154,biological_process cell communication;GO:0007202,biological_process activation of phospholipase C activity;GO:0007275,biological_process multicellular organism development;GO:0008201,molecular_function heparin binding;GO:0009303,biological_process rRNA transcription;GO:0009725,biological_process response to hormone;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0017148,biological_process negative regulation of translation;GO:0019843,molecular_function rRNA binding;GO:0030041,biological_process actin filament polymerization;GO:0030154,biological_process cell differentiation;GO:0030426,cellular_component growth cone;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032148,biological_process activation of protein kinase B activity;GO:0032311,cellular_component angiogenin-PRI complex;GO:0032431,biological_process activation of phospholipase A2 activity;GO:0034332,biological_process adherens junction organization;GO:0042277,molecular_function peptide binding;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042592,biological_process homeostatic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050714,biological_process positive regulation of protein secretion;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis	NA	angiogenin [Source:HGNC Symbol%3BAcc:HGNC:483]
ENSG00000076382	19.24	20.85	17.78	22.64	23.24	22.42	-0.229929112878014	6.28797760274987	0.00124856398593667	0.0284897513923381	17:28577564-28599279:-	SPAG5	29;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007059,biological_process chromosome segregation;GO:0008017,molecular_function microtubule binding;GO:0030496,cellular_component midbody;GO:0032388,biological_process positive regulation of intracellular transport;GO:0034451,cellular_component centriolar satellite;GO:0035371,cellular_component microtubule plus-end;GO:0051294,biological_process establishment of spindle orientation;GO:0051301,biological_process cell division;GO:0051988,biological_process regulation of attachment of spindle microtubules to kinetochore;GO:0071539,biological_process protein localization to centrosome;GO:0072686,cellular_component mitotic spindle;GO:0090235,biological_process regulation of metaphase plate congression;GO:0097431,cellular_component mitotic spindle pole;GO:1905832,biological_process positive regulation of spindle assembly	NA	sperm associated antigen 5 [Source:HGNC Symbol%3BAcc:HGNC:13452]
ENSG00000146282	40.44	41.88	39.36	36.04	34.38	35.86	0.205127822469109	6.14032455545921	0.00125442320456906	0.0285709270427812	6:87514377-87590003:-	RARS2	13;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004814,molecular_function arginine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006420,biological_process arginyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity;GO:0032543,biological_process mitochondrial translation	RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]; K01887	arginyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:21406]
ENSG00000112096	342.44	362.67	345.52	310.68	309.91	308.48	0.188776360794858	8.42977436830773	0.00126786827032693	0.0288242652739344	6:159669056-159762529:-	SOD2	84;GO:0000302,biological_process response to reactive oxygen species;GO:0000303,biological_process response to superoxide;GO:0001306,biological_process age-dependent response to oxidative stress;GO:0001315,biological_process age-dependent response to reactive oxygen species;GO:0001666,biological_process response to hypoxia;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001889,biological_process liver development;GO:0003032,biological_process detection of oxygen;GO:0003069,biological_process vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure;GO:0003677,molecular_function DNA binding;GO:0004784,molecular_function superoxide dismutase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006749,biological_process glutathione metabolic process;GO:0006801,biological_process superoxide metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0007005,biological_process mitochondrion organization;GO:0007507,biological_process heart development;GO:0007568,biological_process aging;GO:0007626,biological_process locomotory behavior;GO:0008217,biological_process regulation of blood pressure;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009314,biological_process response to radiation;GO:0009409,biological_process response to cold;GO:0009791,biological_process post-embryonic development;GO:0010042,biological_process response to manganese ion;GO:0010043,biological_process response to zinc ion;GO:0010269,biological_process response to selenium ion;GO:0010332,biological_process response to gamma radiation;GO:0014823,biological_process response to activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019430,biological_process removal of superoxide radicals;GO:0019825,molecular_function oxygen binding;GO:0019899,molecular_function enzyme binding;GO:0022904,biological_process respiratory electron transport chain;GO:0030097,biological_process hemopoiesis;GO:0030145,molecular_function manganese ion binding;GO:0030335,biological_process positive regulation of cell migration;GO:0031667,biological_process response to nutrient levels;GO:0032364,biological_process oxygen homeostasis;GO:0032496,biological_process response to lipopolysaccharide;GO:0033591,biological_process response to L-ascorbic acid;GO:0034021,biological_process response to silicon dioxide;GO:0034599,biological_process cellular response to oxidative stress;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0035900,biological_process response to isolation stress;GO:0035902,biological_process response to immobilization stress;GO:0042311,biological_process vasodilation;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042554,biological_process superoxide anion generation;GO:0042645,cellular_component mitochondrial nucleoid;GO:0042743,biological_process hydrogen peroxide metabolic process;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043209,cellular_component myelin sheath;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0048666,biological_process neuron development;GO:0048678,biological_process response to axon injury;GO:0048773,biological_process erythrophore differentiation;GO:0050665,biological_process hydrogen peroxide biosynthetic process;GO:0050790,biological_process regulation of catalytic activity;GO:0051260,biological_process protein homooligomerization;GO:0051289,biological_process protein homotetramerization;GO:0051602,biological_process response to electrical stimulus;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055072,biological_process iron ion homeostasis;GO:0055093,biological_process response to hyperoxia;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0071000,biological_process response to magnetism;GO:0071361,biological_process cellular response to ethanol;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]; K04564	superoxide dismutase 2 [Source:HGNC Symbol%3BAcc:HGNC:11180]
ENSG00000171314	620.80	761.64	554.62	776.13	943.25	768.70	-0.349707195469394	9.13506101576296	0.00127182175680764	0.0288612860461668	10:97426159-97433441:+	PGAM1	25;GO:0003824,molecular_function catalytic activity;GO:0004082,molecular_function bisphosphoglycerate mutase activity;GO:0004619,molecular_function phosphoglycerate mutase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0006110,biological_process regulation of glycolytic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016853,molecular_function isomerase activity;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0019901,molecular_function protein kinase binding;GO:0034774,cellular_component secretory granule lumen;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0043456,biological_process regulation of pentose-phosphate shunt;GO:0045730,biological_process respiratory burst;GO:0046538,molecular_function 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	phosphoglycerate mutase 1 [Source:HGNC Symbol%3BAcc:HGNC:8888]
ENSG00000107862	16.36	19.72	17.71	14.97	16.05	14.41	0.253450593532714	6.52806568164167	0.00128067537421652	0.0290091668250906	10:102245531-102382899:+	GBF1	44;GO:0000139,cellular_component Golgi membrane;GO:0002263,biological_process cell activation involved in immune response;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006895,biological_process Golgi to endosome transport;GO:0007030,biological_process Golgi organization;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0030593,biological_process neutrophil chemotaxis;GO:0031252,cellular_component cell leading edge;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048205,biological_process COPI coating of Golgi vesicle;GO:0061162,biological_process establishment of monopolar cell polarity;GO:0070973,biological_process protein localization to endoplasmic reticulum exit site;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:0090166,biological_process Golgi disassembly;GO:0097111,biological_process endoplasmic reticulum-Golgi intermediate compartment organization;GO:0098586,biological_process cellular response to virus;GO:1903409,biological_process reactive oxygen species biosynthetic process;GO:1903420,biological_process protein localization to endoplasmic reticulum tubular network;GO:2000008,biological_process regulation of protein localization to cell surface	NA	golgi brefeldin A resistant guanine nucleotide exchange factor 1 [Source:HGNC Symbol%3BAcc:HGNC:4181]
ENSG00000213213	90.16	68.96	98.64	67.30	58.14	75.59	0.371759276663884	6.94129648749785	0.00130343325324825	0.0294708870174326	9:136796349-136807741:+	CCDC183	3;GO:0003341,biological_process cilium movement;GO:0005930,cellular_component axoneme;GO:0036158,biological_process outer dynein arm assembly	NA	coiled-coil domain containing 183 [Source:HGNC Symbol%3BAcc:HGNC:28236]
ENSG00000119899	22.40	27.80	23.10	18.86	21.76	18.70	0.311499275747608	5.03715589180211	0.00130662035929244	0.0294892336725402	6:73593378-73654155:-	SLC17A5	23;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0006865,biological_process amino acid transport;GO:0015136,molecular_function sialic acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015538,molecular_function sialic acid:proton symporter activity;GO:0015739,biological_process sialic acid transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045202,cellular_component synapse;GO:0055085,biological_process transmembrane transport;GO:1905039,biological_process carboxylic acid transmembrane transport	SLC17A5; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5; K12301	solute carrier family 17 member 5 [Source:HGNC Symbol%3BAcc:HGNC:10933]
ENSG00000013810	41.18	46.50	39.09	49.36	51.94	49.16	-0.237801229913704	6.87804883726075	0.00134069206795991	0.030116666342713	4:1721489-1745176:+	TACC3	14;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007091,biological_process metaphase/anaphase transition of mitotic cell cycle;GO:0008283,biological_process cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0021987,biological_process cerebral cortex development;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization;GO:1902850,biological_process microtubule cytoskeleton organization involved in mitosis	TACC3, maskin; transforming acidic coiled-coil-containing protein 3; K14283	transforming acidic coiled-coil containing protein 3 [Source:HGNC Symbol%3BAcc:HGNC:11524]
ENSG00000145632	82.14	96.22	80.84	72.14	76.73	71.55	0.244075158192706	7.36088125036188	0.00134096484693128	0.030116666342713	5:58453981-58460260:-	PLK2	41;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000785,cellular_component chromatin;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007052,biological_process mitotic spindle organization;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007265,biological_process Ras protein signal transduction;GO:0007613,biological_process memory;GO:0010508,biological_process positive regulation of autophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030425,cellular_component dendrite;GO:0032092,biological_process positive regulation of protein binding;GO:0032403,molecular_function protein complex binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032486,biological_process Rap protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043008,molecular_function ATP-dependent protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046599,biological_process regulation of centriole replication;GO:0048167,biological_process regulation of synaptic plasticity;GO:0060291,biological_process long-term synaptic potentiation;GO:0060292,biological_process long term synaptic depression;GO:0061000,biological_process negative regulation of dendritic spine development	PLK2; polo-like kinase 2 [EC:2.7.11.21]; K08861	polo like kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:19699]
ENSG00000088808	6.74	6.55	6.43	7.84	8.11	7.77	-0.253678275604742	4.70438278392874	0.00134169954785469	0.030116666342713	14:103733751-103847590:-	PPP1R13B	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0008134,molecular_function transcription factor binding;GO:0042981,biological_process regulation of apoptotic process;GO:0045786,biological_process negative regulation of cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1901216,biological_process positive regulation of neuron death;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	protein phosphatase 1 regulatory subunit 13B [Source:HGNC Symbol%3BAcc:HGNC:14950]
ENSG00000076826	1.62	1.87	2.00	2.19	3.03	2.55	-0.490629294246378	3.11187796277812	0.00135656001493357	0.0303952697930874	19:7595901-7618304:+	CAMSAP3	19;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005912,cellular_component adherens junction;GO:0005915,cellular_component zonula adherens;GO:0008017,molecular_function microtubule binding;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0030054,cellular_component cell junction;GO:0030507,molecular_function spectrin binding;GO:0031175,biological_process neuron projection development;GO:0033043,biological_process regulation of organelle organization;GO:0034453,biological_process microtubule anchoring;GO:0045218,biological_process zonula adherens maintenance;GO:0051011,molecular_function microtubule minus-end binding;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0090136,biological_process epithelial cell-cell adhesion	NA	calmodulin regulated spectrin associated protein family member 3 [Source:HGNC Symbol%3BAcc:HGNC:29307]
ENSG00000250644	2.47	1.98	2.75	1.77	1.61	1.35	0.635838866887423	2.06804353765519	0.00135990143871787	0.0304152370428918	11:1734820-1763954:-	AC068580.4	10;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0006914,biological_process autophagy;GO:0008233,molecular_function peptidase activity;GO:0009607,biological_process response to biotic stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030163,biological_process protein catabolic process	CTSD; cathepsin D [EC:3.4.23.5]; K01379	NA
ENSG00000079337	10.39	10.36	10.19	9.05	8.81	8.43	0.246925616406736	4.83053814780612	0.00137482669129808	0.0306937476961926	12:47734366-47771040:-	RAPGEF3	35;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008283,biological_process cell proliferation;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0017034,molecular_function Rap guanyl-nucleotide exchange factor activity;GO:0019904,molecular_function protein domain specific binding;GO:0019933,biological_process cAMP-mediated signaling;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0030552,molecular_function cAMP binding;GO:0030822,biological_process positive regulation of cAMP catabolic process;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0032486,biological_process Rap protein signal transduction;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034242,biological_process negative regulation of syncytium formation by plasma membrane fusion;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0050796,biological_process regulation of insulin secretion;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0060143,biological_process positive regulation of syncytium formation by plasma membrane fusion;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0071320,biological_process cellular response to cAMP;GO:1901985,biological_process positive regulation of protein acetylation;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3; K08014	Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol%3BAcc:HGNC:16629]
ENSG00000105520	13.75	14.31	18.02	11.82	12.36	12.03	0.362291023219239	4.22818664641846	0.00138739412641779	0.0309187132697021	19:11355385-11365698:+	PLPPR2	9;GO:0005887,cellular_component integral component of plasma membrane;GO:0006644,biological_process phospholipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0042577,molecular_function lipid phosphatase activity;GO:0046839,biological_process phospholipid dephosphorylation	NA	phospholipid phosphatase related 2 [Source:HGNC Symbol%3BAcc:HGNC:29566]
ENSG00000101307	2.44	2.68	2.33	2.07	1.32	1.63	0.572867839058144	2.38607958150509	0.00139560884127188	0.0310118033776344	20:1563520-1620061:-	SIRPB1	11;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome	SIRPA_B1_G, CD172; signal-regulatory protein alpha/beta1/gamma; K06551	signal regulatory protein beta 1 [Source:HGNC Symbol%3BAcc:HGNC:15928]
ENSG00000138778	9.81	9.55	9.48	10.96	12.23	10.76	-0.222927376808706	6.41050684010387	0.00139656796004976	0.0310118033776344	4:103105805-103198409:-	CENPE	43;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007079,biological_process mitotic chromosome movement towards spindle pole;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007275,biological_process multicellular organism development;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0030496,cellular_component midbody;GO:0043515,molecular_function kinetochore binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0051301,biological_process cell division;GO:0051310,biological_process metaphase plate congression;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0051382,biological_process kinetochore assembly;GO:0099607,biological_process lateral attachment of mitotic spindle microtubules to kinetochore;GO:1990023,cellular_component mitotic spindle midzone	NA	centromere protein E [Source:HGNC Symbol%3BAcc:HGNC:1856]
ENSG00000077984	0.97	0.00	0.51	2.41	0.70	2.42	-1.73666182034198	-0.54912874555612	0.00140200569490318	0.0310769583764878	20:24949229-24959928:+	CST7	11;GO:0002020,molecular_function protease binding;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006955,biological_process immune response;GO:0010466,biological_process negative regulation of peptidase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:2000117,biological_process negative regulation of cysteine-type endopeptidase activity	NA	cystatin F [Source:HGNC Symbol%3BAcc:HGNC:2479]
ENSG00000167165	303.16	333.01	309.77	258.82	297.35	251.05	0.240300770727826	8.89184080674766	0.00140681502866372	0.0311279767393989	2:233691606-233773300:+	UGT1A6	17;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046982,molecular_function protein heterodimerization activity;GO:0052695,biological_process cellular glucuronidation;GO:0052696,biological_process flavonoid glucuronidation;GO:0052697,biological_process xenobiotic glucuronidation;GO:0070062,cellular_component extracellular exosome	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 1 member A6 [Source:HGNC Symbol%3BAcc:HGNC:12538]
ENSG00000101928	31.57	31.41	32.10	23.21	28.71	25.30	0.313123037154978	4.21422696725	0.00141094766742923	0.0311638672523114	X:134887625-134915267:-	MOSPD1	7;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	motile sperm domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25235]
ENSG00000185133	0.26	0.35	0.20	0.60	0.60	0.49	-1.08539601074201	0.491567236619424	0.00141546911521693	0.0312082027125892	22:31122730-31134696:+	INPP5J	20;GO:0001726,cellular_component ruffle;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445,molecular_function inositol-polyphosphate 5-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030426,cellular_component growth cone;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034485,molecular_function phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0043198,cellular_component dendritic shaft;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0052658,molecular_function inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	E3.1.3.56; inositol-1,4,5-trisphosphate 5-phosphatase [EC:3.1.3.56]; K01106	inositol polyphosphate-5-phosphatase J [Source:HGNC Symbol%3BAcc:HGNC:8956]
ENSG00000105875	29.42	27.79	29.10	26.55	24.04	24.44	0.215703198428366	5.92893547498165	0.00142448184566494	0.0313512289897853	7:135183838-135211534:-	WDR91	NA	NA	WD repeat domain 91 [Source:HGNC Symbol%3BAcc:HGNC:24997]
ENSG00000100028	206.65	206.41	184.97	224.79	250.52	231.76	-0.230703288585501	6.51341610244836	0.00143906334978644	0.0315969369152957	22:24555502-24609980:+	SNRPD3	42;GO:0000243,cellular_component commitment complex;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005683,cellular_component U7 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006479,biological_process protein methylation;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0019899,molecular_function enzyme binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0030620,molecular_function U2 snRNA binding;GO:0034709,cellular_component methylosome;GO:0034715,cellular_component pICln-Sm protein complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0070034,molecular_function telomerase RNA binding;GO:0070062,cellular_component extracellular exosome;GO:0071010,cellular_component prespliceosome;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071208,molecular_function histone pre-mRNA DCP binding;GO:0071209,molecular_function U7 snRNA binding;GO:0097526,cellular_component spliceosomal tri-snRNP complex;GO:1990446,molecular_function U1 snRNP binding	SNRPD3, SMD3; small nuclear ribonucleoprotein D3; K11088	small nuclear ribonucleoprotein D3 polypeptide [Source:HGNC Symbol%3BAcc:HGNC:11160]
ENSG00000143393	22.20	20.94	22.80	19.21	19.40	18.85	0.21300061236111	5.75406431680601	0.00144073683187443	0.0315969369152957	1:151291796-151327715:-	PI4KB	26;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0004430,molecular_function 1-phosphatidylinositol 4-kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030867,cellular_component rough endoplasmic reticulum membrane;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071889,molecular_function 14-3-3 protein binding	PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]; K00888	phosphatidylinositol 4-kinase beta [Source:HGNC Symbol%3BAcc:HGNC:8984]
ENSG00000110697	14.65	15.26	14.12	12.98	12.21	12.96	0.215593292874723	5.67916722795326	0.00144470061092052	0.0316279870958668	11:67491767-67506263:-	PITPNM1	25;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0007420,biological_process brain development;GO:0007602,biological_process phototransduction;GO:0008526,molecular_function phosphatidylinositol transporter activity;GO:0015031,biological_process protein transport;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0030496,cellular_component midbody;GO:0031210,molecular_function phosphatidylcholine binding;GO:0032154,cellular_component cleavage furrow;GO:0032580,cellular_component Golgi cisterna membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0046872,molecular_function metal ion binding;GO:0070300,molecular_function phosphatidic acid binding	NA	phosphatidylinositol transfer protein membrane associated 1 [Source:HGNC Symbol%3BAcc:HGNC:9003]
ENSG00000198832	71.44	53.38	63.62	51.64	48.82	51.40	0.331003346723324	4.63784965111832	0.00144891721139411	0.0316644530722448	22:31104771-31120069:-	SELENOM	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0010269,biological_process response to selenium ion;GO:0035264,biological_process multicellular organism growth;GO:0035934,biological_process corticosterone secretion;GO:0042445,biological_process hormone metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060612,biological_process adipose tissue development	NA	selenoprotein M [Source:HGNC Symbol%3BAcc:HGNC:30397]
ENSG00000151176	32.26	30.39	30.20	25.42	25.32	28.93	0.232468626322644	5.67194927250937	0.00147823549392666	0.0322483957576655	12:113358565-113391625:+	PLBD2	6;GO:0005764,cellular_component lysosome;GO:0006629,biological_process lipid metabolic process;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0043202,cellular_component lysosomal lumen;GO:0070062,cellular_component extracellular exosome	NA	phospholipase B domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:27283]
ENSG00000198794	3.68	2.66	2.77	0.91	1.75	2.22	0.915141620760803	1.05459963840381	0.00149014742025642	0.0324081609292026	15:74957218-75021496:+	SCAMP5	21;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0045202,cellular_component synapse;GO:0045806,biological_process negative regulation of endocytosis;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0055038,cellular_component recycling endosome membrane	NA	secretory carrier membrane protein 5 [Source:HGNC Symbol%3BAcc:HGNC:30386]
ENSG00000163249	28.73	31.09	28.53	25.23	24.80	25.33	0.236801540441177	5.0397062910733	0.00149078062439174	0.0324081609292026	2:207711539-207761839:+	CCNYL1	9;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030317,biological_process sperm motility;GO:0045859,biological_process regulation of protein kinase activity	NA	cyclin Y like 1 [Source:HGNC Symbol%3BAcc:HGNC:26868]
ENSG00000179051	47.90	43.21	45.40	57.13	50.27	53.48	-0.223350571371405	6.28359612849342	0.00151006521711927	0.0327699991959817	1:17406759-17439724:-	RCC2	38;GO:0000775,cellular_component chromosome, centromeric region;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008017,molecular_function microtubule binding;GO:0010762,biological_process regulation of fibroblast migration;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030334,biological_process regulation of cell migration;GO:0030496,cellular_component midbody;GO:0031267,molecular_function small GTPase binding;GO:0031901,cellular_component early endosome membrane;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034506,cellular_component chromosome, centromeric core domain;GO:0045184,biological_process establishment of protein localization;GO:0048041,biological_process focal adhesion assembly;GO:0048365,molecular_function Rac GTPase binding;GO:0051301,biological_process cell division;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0051987,biological_process positive regulation of attachment of spindle microtubules to kinetochore;GO:0072356,biological_process chromosome passenger complex localization to kinetochore;GO:0090630,biological_process activation of GTPase activity;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:1900027,biological_process regulation of ruffle assembly;GO:1990023,cellular_component mitotic spindle midzone	NA	regulator of chromosome condensation 2 [Source:HGNC Symbol%3BAcc:HGNC:30297]
ENSG00000118849	3.95	3.74	4.12	2.34	2.63	2.52	0.670791228281286	1.59277976903616	0.00151865278167999	0.032898842895277	3:158696891-158732696:-	RARRES1	4;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	retinoic acid receptor responder 1 [Source:HGNC Symbol%3BAcc:HGNC:9867]
ENSG00000169855	8.07	7.47	7.55	6.82	5.98	6.82	0.246784251532446	5.2263322001396	0.00152650634255894	0.0329243649889993	3:78597239-79767815:-	ROBO1	31;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007507,biological_process heart development;GO:0008046,molecular_function axon guidance receptor activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016199,biological_process axon midline choice point recognition;GO:0021836,biological_process chemorepulsion involved in postnatal olfactory bulb interneuron migration;GO:0030154,biological_process cell differentiation;GO:0030275,molecular_function LRR domain binding;GO:0030336,biological_process negative regulation of cell migration;GO:0030424,cellular_component axon;GO:0033600,biological_process negative regulation of mammary gland epithelial cell proliferation;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035385,biological_process Roundabout signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050925,biological_process negative regulation of negative chemotaxis;GO:0070100,biological_process negative regulation of chemokine-mediated signaling pathway	ROBO1; roundabout, axon guidance receptor 1; K06753	roundabout guidance receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:10249]
ENSG00000110200	34.39	40.88	32.23	41.22	51.95	44.00	-0.346010711872193	4.82543631016029	0.00152743930035961	0.0329243649889993	11:72106377-72112780:-	ANAPC15	13;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0090266,biological_process regulation of mitotic cell cycle spindle assembly checkpoint	NA	anaphase promoting complex subunit 15 [Source:HGNC Symbol%3BAcc:HGNC:24531]
ENSG00000170961	1.45	1.79	2.13	1.27	1.05	0.72	0.833221555660851	1.29134179918113	0.00152914440446169	0.0329243649889993	8:121612115-121641390:-	HAS2	32;GO:0001570,biological_process vasculogenesis;GO:0001822,biological_process kidney development;GO:0005737,cellular_component cytoplasm;GO:0005887,cellular_component integral component of plasma membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010838,biological_process positive regulation of keratinocyte proliferation;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030212,biological_process hyaluronan metabolic process;GO:0030213,biological_process hyaluronan biosynthetic process;GO:0030335,biological_process positive regulation of cell migration;GO:0035810,biological_process positive regulation of urine volume;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0036302,biological_process atrioventricular canal development;GO:0044849,biological_process estrous cycle;GO:0045226,biological_process extracellular polysaccharide biosynthetic process;GO:0050501,molecular_function hyaluronan synthase activity;GO:0051549,biological_process positive regulation of keratinocyte migration;GO:0060349,biological_process bone morphogenesis;GO:0070295,biological_process renal water absorption;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071498,biological_process cellular response to fluid shear stress;GO:0085029,biological_process extracellular matrix assembly;GO:0090500,biological_process endocardial cushion to mesenchymal transition;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1900127,biological_process positive regulation of hyaluronan biosynthetic process;GO:1900625,biological_process positive regulation of monocyte aggregation;GO:1901201,biological_process regulation of extracellular matrix assembly	NA	hyaluronan synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:4819]
ENSG00000272391	15.52	14.57	15.47	12.94	13.78	12.91	0.215425742823755	5.71487270503817	0.00153044055414909	0.0329243649889993	7:75416786-75486271:-	POM121C	4;GO:0005654,cellular_component nucleoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane	POM121, NUP121; nuclear pore complex protein Nup121; K14316	POM121 transmembrane nucleoporin C [Source:HGNC Symbol%3BAcc:HGNC:34005]
ENSG00000139329	4.60	7.26	4.79	7.24	10.85	7.91	-0.647569443488076	2.87374861359966	0.00154595099283959	0.0332005011662938	12:91102628-91111831:-	LUM	21;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005583,cellular_component fibrillar collagen trimer;GO:0005615,cellular_component extracellular space;GO:0005796,cellular_component Golgi lumen;GO:0007601,biological_process visual perception;GO:0014070,biological_process response to organic cyclic compound;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0031012,cellular_component extracellular matrix;GO:0032914,biological_process positive regulation of transforming growth factor beta1 production;GO:0042340,biological_process keratan sulfate catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051216,biological_process cartilage development;GO:0070062,cellular_component extracellular exosome;GO:0070848,biological_process response to growth factor	LUM; lumican; K08122	lumican [Source:HGNC Symbol%3BAcc:HGNC:6724]
ENSG00000142657	114.56	127.44	108.04	90.30	107.30	98.28	0.25329495004434	7.30329978674948	0.00156944141165821	0.0336268022364231	1:10398591-10420144:+	PGD	11;GO:0004616,molecular_function phosphogluconate dehydrogenase (decarboxylating) activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006098,biological_process pentose-phosphate shunt;GO:0009051,biological_process pentose-phosphate shunt, oxidative branch;GO:0016491,molecular_function oxidoreductase activity;GO:0019322,biological_process pentose biosynthetic process;GO:0019521,biological_process D-gluconate metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]; K00033	phosphogluconate dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:8891]
ENSG00000154721	11.79	11.09	12.78	9.82	7.66	9.75	0.403337965643439	3.49362969392341	0.00157134231174417	0.0336268022364231	21:25639271-25717562:+	JAM2	12;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007162,biological_process negative regulation of cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0046982,molecular_function protein heterodimerization activity;GO:0050900,biological_process leukocyte migration	JAM2, CD322; junctional adhesion molecule 2; K06735	junctional adhesion molecule 2 [Source:HGNC Symbol%3BAcc:HGNC:14686]
ENSG00000182578	0.59	0.64	0.52	1.32	0.84	0.94	-0.823177183570509	1.3690451382175	0.00157392830897944	0.0336268022364231	5:150053290-150113372:-	CSF1R	60;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005011,molecular_function macrophage colony-stimulating factor receptor activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019903,molecular_function protein phosphatase binding;GO:0019955,molecular_function cytokine binding;GO:0021772,biological_process olfactory bulb development;GO:0021879,biological_process forebrain neuron differentiation;GO:0030097,biological_process hemopoiesis;GO:0030224,biological_process monocyte differentiation;GO:0030225,biological_process macrophage differentiation;GO:0030316,biological_process osteoclast differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0031529,biological_process ruffle organization;GO:0036006,biological_process cellular response to macrophage colony-stimulating factor stimulus;GO:0038145,biological_process macrophage colony-stimulating factor signaling pathway;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045087,biological_process innate immune response;GO:0045124,biological_process regulation of bone resorption;GO:0045217,biological_process cell-cell junction maintenance;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046777,biological_process protein autophosphorylation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0060603,biological_process mammary gland duct morphogenesis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090197,biological_process positive regulation of chemokine secretion;GO:1990682,cellular_component CSF1-CSF1R complex;GO:2000147,biological_process positive regulation of cell motility;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]; K05090	colony stimulating factor 1 receptor [Source:HGNC Symbol%3BAcc:HGNC:2433]
ENSG00000129128	40.68	44.60	45.80	32.31	36.38	38.54	0.297957737600756	4.43044088929603	0.00157934838512951	0.0336740243062767	4:176319963-176332245:+	SPCS3	12;GO:0005783,cellular_component endoplasmic reticulum;GO:0005787,cellular_component signal peptidase complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045047,biological_process protein targeting to ER	SPCS3, SPC3; signal peptidase complex subunit 3 [EC:3.4.-.-]; K12948	signal peptidase complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:26212]
ENSG00000173209	118.76	112.26	122.67	106.97	94.92	104.48	0.220137686252525	6.47575776181334	0.00158156418033991	0.0336740243062767	2:61177417-61191203:+	AHSA2	4;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0051087,molecular_function chaperone binding	NA	activator of HSP90 ATPase homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:20437]
ENSG00000137504	52.90	54.18	57.75	47.66	47.98	48.44	0.206088396478099	6.02659831683134	0.00159723521317918	0.0339494532554677	11:85659707-85682908:-	CREBZF	12;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009615,biological_process response to virus;GO:0042802,molecular_function identical protein binding;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity	NA	CREB/ATF bZIP transcription factor [Source:HGNC Symbol%3BAcc:HGNC:24905]
ENSG00000111057	102.41	91.86	101.88	130.03	102.87	128.38	-0.274117486528237	7.14778315267986	0.00160421857577884	0.034039598600244	12:52948870-52952901:+	KRT18	29;GO:0003723,molecular_function RNA binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0005913,cellular_component cell-cell adherens junction;GO:0007049,biological_process cell cycle;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016032,biological_process viral process;GO:0031424,biological_process keratinization;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034451,cellular_component centriolar satellite;GO:0043000,biological_process Golgi to plasma membrane CFTR protein transport;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045095,cellular_component keratin filament;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0071944,cellular_component cell periphery;GO:0097110,molecular_function scaffold protein binding;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097284,biological_process hepatocyte apoptotic process;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	KRT1; type I keratin, acidic; K07604	keratin 18 [Source:HGNC Symbol%3BAcc:HGNC:6430]
ENSG00000122068	31.31	29.02	33.77	38.08	35.48	38.75	-0.239687091140859	5.40628584418717	0.00161334749374605	0.0341507391430002	3:197737178-197787596:+	FYTTD1	10;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0016607,cellular_component nuclear speck;GO:0051028,biological_process mRNA transport	NA	forty-two-three domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25407]
ENSG00000172292	4.92	6.26	5.63	7.39	8.00	7.47	-0.443165429924221	2.98733093915541	0.00161495882356732	0.0341507391430002	2:168455861-168775137:+	CERS6	11;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0031965,cellular_component nuclear membrane;GO:0046513,biological_process ceramide biosynthetic process;GO:0050291,molecular_function sphingosine N-acyltransferase activity	CERS1_2_3_4, LASS1_2_3_4; ceramide synthetase [EC:2.3.1.24]; K04710	ceramide synthase 6 [Source:HGNC Symbol%3BAcc:HGNC:23826]
ENSG00000134470	3.33	2.86	4.11	6.76	3.85	5.42	-0.618754226736117	3.15234369419172	0.00162257983324881	0.0342535433165264	10:5943638-5978187:-	IL15RA	23;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0004896,molecular_function cytokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007259,biological_process JAK-STAT cascade;GO:0008283,biological_process cell proliferation;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031667,biological_process response to nutrient levels;GO:0031965,cellular_component nuclear membrane;GO:0032825,biological_process positive regulation of natural killer cell differentiation	IL15RA, CD215; interleukin 15 receptor alpha; K05074	interleukin 15 receptor subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:5978]
ENSG00000108840	14.54	14.40	14.59	12.80	11.93	13.08	0.214200478699827	5.55030117654459	0.00163376893845855	0.0344311949627945	17:44076745-44123702:-	HDAC5	49;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001025,molecular_function RNA polymerase III transcription factor binding;GO:0001047,molecular_function core promoter binding;GO:0003682,molecular_function chromatin binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006342,biological_process chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006476,biological_process protein deacetylation;GO:0006954,biological_process inflammatory response;GO:0008134,molecular_function transcription factor binding;GO:0010830,biological_process regulation of myotube differentiation;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0014823,biological_process response to activity;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0030182,biological_process neuron differentiation;GO:0030183,biological_process B cell differentiation;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0032869,biological_process cellular response to insulin stimulus;GO:0033558,molecular_function protein deacetylase activity;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042113,biological_process B cell activation;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042826,molecular_function histone deacetylase binding;GO:0043234,cellular_component protein complex;GO:0043393,biological_process regulation of protein binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0070491,molecular_function repressing transcription factor binding;GO:0070932,biological_process histone H3 deacetylation;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis	HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]; K11406	histone deacetylase 5 [Source:HGNC Symbol%3BAcc:HGNC:14068]
ENSG00000132912	18.86	21.13	19.30	24.16	22.15	25.04	-0.261396188681497	4.9766325895991	0.00164350444087558	0.034552169440867	5:150708439-150759109:-	DCTN4	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005869,cellular_component dynactin complex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007097,biological_process nuclear migration;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0047485,molecular_function protein N-terminus binding	DCTN4; dynactin 4; K10426	dynactin subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:15518]
ENSG00000188064	14.03	13.72	12.90	17.19	15.32	18.31	-0.312438567957875	4.20722611361162	0.0016450763022277	0.034552169440867	22:45920361-45977129:-	WNT7B	53;GO:0001701,biological_process in utero embryonic development;GO:0003338,biological_process metanephros morphogenesis;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0007257,biological_process activation of JUN kinase activity;GO:0007275,biological_process multicellular organism development;GO:0016055,biological_process Wnt signaling pathway;GO:0016332,biological_process establishment or maintenance of polarity of embryonic epithelium;GO:0021871,biological_process forebrain regionalization;GO:0022009,biological_process central nervous system vasculogenesis;GO:0030182,biological_process neuron differentiation;GO:0030324,biological_process lung development;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031175,biological_process neuron projection development;GO:0032364,biological_process oxygen homeostasis;GO:0032536,biological_process regulation of cell projection size;GO:0042592,biological_process homeostatic process;GO:0044237,biological_process cellular metabolic process;GO:0045165,biological_process cell fate commitment;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048144,biological_process fibroblast proliferation;GO:0048568,biological_process embryonic organ development;GO:0048812,biological_process neuron projection morphogenesis;GO:0050808,biological_process synapse organization;GO:0051384,biological_process response to glucocorticoid;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060425,biological_process lung morphogenesis;GO:0060428,biological_process lung epithelium development;GO:0060482,biological_process lobar bronchus development;GO:0060535,biological_process trachea cartilage morphogenesis;GO:0060560,biological_process developmental growth involved in morphogenesis;GO:0060669,biological_process embryonic placenta morphogenesis;GO:0060710,biological_process chorio-allantoic fusion;GO:0061180,biological_process mammary gland epithelium development;GO:0070062,cellular_component extracellular exosome;GO:0070307,biological_process lens fiber cell development;GO:0071300,biological_process cellular response to retinoic acid;GO:0072053,biological_process renal inner medulla development;GO:0072054,biological_process renal outer medulla development;GO:0072060,biological_process outer medullary collecting duct development;GO:0072061,biological_process inner medullary collecting duct development;GO:0072089,biological_process stem cell proliferation;GO:0072205,biological_process metanephric collecting duct development;GO:0072207,biological_process metanephric epithelium development;GO:0072236,biological_process metanephric loop of Henle development	WNT7; wingless-type MMTV integration site family, member 7; K00572	Wnt family member 7B [Source:HGNC Symbol%3BAcc:HGNC:12787]
ENSG00000114200	1.13	2.09	1.97	1.02	1.14	0.68	0.865735323885721	1.50815244656626	0.00167482394041246	0.0351143869963922	3:165772903-165837472:-	BCHE	28;GO:0001540,molecular_function beta-amyloid binding;GO:0003824,molecular_function catalytic activity;GO:0003990,molecular_function acetylcholinesterase activity;GO:0004104,molecular_function cholinesterase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005641,cellular_component nuclear envelope lumen;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007584,biological_process response to nutrient;GO:0007612,biological_process learning;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014016,biological_process neuroblast differentiation;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0019695,biological_process choline metabolic process;GO:0019899,molecular_function enzyme binding;GO:0033265,molecular_function choline binding;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0043279,biological_process response to alkaloid;GO:0050783,biological_process cocaine metabolic process;GO:0050805,biological_process negative regulation of synaptic transmission;GO:0051384,biological_process response to glucocorticoid;GO:0051593,biological_process response to folic acid;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0072562,cellular_component blood microparticle	NA	butyrylcholinesterase [Source:HGNC Symbol%3BAcc:HGNC:983]
ENSG00000103154	3.35	2.48	3.50	5.17	3.86	5.34	-0.59612743354271	2.26005449896344	0.00167750193255946	0.0351143869963922	16:83968631-84002776:+	NECAB2	16;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031687,molecular_function A2A adenosine receptor binding;GO:0031802,molecular_function type 5 metabotropic glutamate receptor binding;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0060168,biological_process positive regulation of adenosine receptor signaling pathway;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:1900451,biological_process positive regulation of glutamate receptor signaling pathway;GO:1904021,biological_process negative regulation of G-protein coupled receptor internalization;GO:1905477,biological_process positive regulation of protein localization to membrane	NA	N-terminal EF-hand calcium binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:23746]
ENSG00000085982	20.01	16.79	21.61	24.44	22.34	24.00	-0.262138174563205	6.39800439217896	0.00169740005274925	0.0354223855217665	2:233475519-233566782:-	USP40	7;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 40 [Source:HGNC Symbol%3BAcc:HGNC:20069]
ENSG00000105223	126.63	123.29	131.54	116.49	108.80	110.44	0.196456596980311	7.54968188271414	0.00169792309558133	0.0354223855217665	19:40348455-40380439:+	PLD3	12;GO:0003824,molecular_function catalytic activity;GO:0004630,molecular_function phospholipase D activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0070290,molecular_function N-acylphosphatidylethanolamine-specific phospholipase D activity	PLD3_4; phospholipase D3/4 [EC:3.1.4.4]; K16860	phospholipase D family member 3 [Source:HGNC Symbol%3BAcc:HGNC:17158]
ENSG00000197256	36.92	41.42	37.91	33.40	34.18	33.40	0.212518555324901	6.55714449714027	0.00171663098003409	0.0357525844885287	19:11164266-11197791:-	KANK2	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0043069,biological_process negative regulation of programmed cell death;GO:0070563,biological_process negative regulation of vitamin D receptor signaling pathway;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	KN motif and ankyrin repeat domains 2 [Source:HGNC Symbol%3BAcc:HGNC:29300]
ENSG00000094916	44.50	46.70	44.19	54.49	53.61	53.01	-0.242161193152836	4.8327393106369	0.00172583231086342	0.0358815989347907	12:54230939-54280133:-	CBX5	27;GO:0000118,cellular_component histone deacetylase complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000792,cellular_component heterochromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005720,cellular_component nuclear heterochromatin;GO:0005721,cellular_component pericentric heterochromatin;GO:0005730,cellular_component nucleolus;GO:0007596,biological_process blood coagulation;GO:0010369,cellular_component chromocenter;GO:0016032,biological_process viral process;GO:0016605,cellular_component PML body;GO:0017053,cellular_component transcriptional repressor complex;GO:0030674,molecular_function protein binding, bridging;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0035064,molecular_function methylated histone binding;GO:0035097,cellular_component histone methyltransferase complex;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070491,molecular_function repressing transcription factor binding	NA	chromobox 5 [Source:HGNC Symbol%3BAcc:HGNC:1555]
ENSG00000198018	7.65	7.27	7.65	8.61	10.05	9.78	-0.317680734511195	3.9764714776379	0.00172860679634293	0.0358815989347907	10:99659505-99706240:+	ENTPD7	9;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0046872,molecular_function metal ion binding	NA	ectonucleoside triphosphate diphosphohydrolase 7 [Source:HGNC Symbol%3BAcc:HGNC:19745]
ENSG00000168398	3.55	3.83	3.33	2.74	2.00	2.22	0.623201600796509	1.83852639758863	0.00175185862587342	0.0363035411067892	14:96204678-96244166:+	BDKRB2	31;GO:0002020,molecular_function protease binding;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004947,molecular_function bradykinin receptor activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006939,biological_process smooth muscle contraction;GO:0006950,biological_process response to stress;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008015,biological_process blood circulation;GO:0009651,biological_process response to salt stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019229,biological_process regulation of vasoconstriction;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0042310,biological_process vasoconstriction;GO:0042311,biological_process vasodilation;GO:0043114,biological_process regulation of vascular permeability;GO:0046982,molecular_function protein heterodimerization activity;GO:0050482,biological_process arachidonic acid secretion;GO:1902219,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:1902239,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	BDKRB2; bradykinin receptor B2; K03916	bradykinin receptor B2 [Source:HGNC Symbol%3BAcc:HGNC:1030]
ENSG00000129295	7.00	7.32	7.06	8.68	9.08	9.28	-0.330219389302475	3.66884401600865	0.00176239028834697	0.0364609177487516	8:132571952-132675617:-	LRRC6	13;GO:0003341,biological_process cilium movement;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0008584,biological_process male gonad development;GO:0030317,biological_process sperm motility;GO:0036158,biological_process outer dynein arm assembly;GO:0036159,biological_process inner dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry;GO:0061458,biological_process reproductive system development	NA	leucine rich repeat containing 6 [Source:HGNC Symbol%3BAcc:HGNC:16725]
ENSG00000123836	8.03	7.88	6.24	5.64	5.85	5.34	0.404078571089612	3.47677536594392	0.00176670293676912	0.0364893237173295	1:207034365-207081024:+	PFKFB2	27;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003873,molecular_function 6-phosphofructo-2-kinase activity;GO:0004331,molecular_function fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006000,biological_process fructose metabolic process;GO:0006003,biological_process fructose 2,6-bisphosphate metabolic process;GO:0006007,biological_process glucose catabolic process;GO:0006089,biological_process lactate metabolic process;GO:0006090,biological_process pyruvate metabolic process;GO:0006096,biological_process glycolytic process;GO:0008152,biological_process metabolic process;GO:0009749,biological_process response to glucose;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0032024,biological_process positive regulation of insulin secretion;GO:0033133,biological_process positive regulation of glucokinase activity;GO:0045821,biological_process positive regulation of glycolytic process;GO:0046835,biological_process carbohydrate phosphorylation	PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]; K01103	6-phosphofructo-2-kinase/fructose-2%2C6-biphosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:8873]
ENSG00000088325	76.52	83.44	70.41	88.74	95.67	87.86	-0.230457858197815	7.62199244058836	0.00179388458262598	0.0369891849238144	20:31739270-31801805:+	TPX2	26;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019901,molecular_function protein kinase binding;GO:0032147,biological_process activation of protein kinase activity;GO:0043203,cellular_component axon hillock;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0061676,molecular_function importin-alpha family protein binding;GO:0072686,cellular_component mitotic spindle;GO:0090307,biological_process mitotic spindle assembly;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	TPX2%2C microtubule nucleation factor [Source:HGNC Symbol%3BAcc:HGNC:1249]
ENSG00000134709	8.02	6.96	7.52	8.26	10.35	10.05	-0.332394843064327	4.23698602674229	0.00181157882515175	0.0372920861635301	1:59814785-59876378:+	HOOK1	25;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0008017,molecular_function microtubule binding;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030154,biological_process cell differentiation;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0030897,cellular_component HOPS complex;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0042802,molecular_function identical protein binding;GO:0045022,biological_process early endosome to late endosome transport;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0070695,cellular_component FHF complex	NA	hook microtubule tethering protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19884]
ENSG00000158023	0.44	0.49	0.38	0.21	0.17	0.22	1.09708979497153	0.327547553296374	0.00182839230634017	0.0375655718574411	12:121917861-122003927:+	WDR66	7;GO:0001536,cellular_component radial spoke stalk;GO:0003341,biological_process cilium movement;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005930,cellular_component axoneme;GO:0031514,cellular_component motile cilium;GO:0042995,cellular_component cell projection	NA	WD repeat domain 66 [Source:HGNC Symbol%3BAcc:HGNC:28506]
ENSG00000120992	85.93	87.42	85.51	97.38	98.75	102.94	-0.197634944859367	6.01273262449703	0.00183091685924046	0.0375655718574411	8:54046366-54102017:-	LYPLA1	16;GO:0002084,biological_process protein depalmitoylation;GO:0004622,molecular_function lysophospholipase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0008474,molecular_function palmitoyl-(protein) hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016298,molecular_function lipase activity;GO:0016787,molecular_function hydrolase activity;GO:0042997,biological_process negative regulation of Golgi to plasma membrane protein transport;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0070062,cellular_component extracellular exosome	LYPLA1; lysophospholipase I [EC:3.1.1.5]; K06128	lysophospholipase I [Source:HGNC Symbol%3BAcc:HGNC:6737]
ENSG00000178773	1.39	1.17	1.34	0.66	0.89	0.72	0.793816681959032	1.16527866312067	0.00184076465517144	0.0377052997766387	16:89575767-89597246:+	CPNE7	11;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0046474,biological_process glycerophospholipid biosynthetic process;GO:0070062,cellular_component extracellular exosome;GO:0071277,biological_process cellular response to calcium ion	NA	copine 7 [Source:HGNC Symbol%3BAcc:HGNC:2320]
ENSG00000139620	16.20	16.28	18.36	20.28	20.43	19.68	-0.234136253348098	5.29200957394296	0.00185144378247383	0.0377930207702169	12:48653400-48682238:-	KANSL2	14;GO:0000123,cellular_component histone acetyltransferase complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0015629,cellular_component actin cytoskeleton;GO:0016569,biological_process covalent chromatin modification;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific)	NA	KAT8 regulatory NSL complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:26024]
ENSG00000198768	8.51	7.90	8.54	6.61	7.13	5.94	0.360126851325668	3.57670420088202	0.00185425876907996	0.0377930207702169	20:58459100-58515131:-	APCDD1L	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	APC down-regulated 1 like [Source:HGNC Symbol%3BAcc:HGNC:26892]
ENSG00000105835	142.53	140.52	143.49	125.44	126.46	127.50	0.180960248501233	7.6450011686839	0.0018565457471939	0.0377930207702169	7:106248284-106286326:-	NAMPT	30;GO:0004514,molecular_function nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007565,biological_process female pregnancy;GO:0007623,biological_process circadian rhythm;GO:0008144,molecular_function drug binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009435,biological_process NAD biosynthetic process;GO:0014070,biological_process response to organic cyclic compound;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0030054,cellular_component cell junction;GO:0032922,biological_process circadian regulation of gene expression;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047280,molecular_function nicotinamide phosphoribosyltransferase activity;GO:0048511,biological_process rhythmic process;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051770,biological_process positive regulation of nitric-oxide synthase biosynthetic process;GO:0070062,cellular_component extracellular exosome	NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12]; K03462	nicotinamide phosphoribosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:30092]
ENSG00000137200	25.79	25.41	24.83	28.68	29.71	29.29	-0.193954016759934	6.16914310848967	0.00185722570448983	0.0377930207702169	6:37433218-37482827:+	CMTR1	12;GO:0003676,molecular_function nucleic acid binding;GO:0004483,molecular_function mRNA (nucleoside-2'-O-)-methyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006397,biological_process mRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0080009,biological_process mRNA methylation;GO:0097309,biological_process cap1 mRNA methylation	NA	cap methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:21077]
ENSG00000162434	129.71	133.91	126.05	146.07	148.64	150.43	-0.180481142690496	8.91306707085326	0.00190360891943814	0.0386299397170261	1:64833228-64966504:-	JAK1	44;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005131,molecular_function growth hormone receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0019903,molecular_function protein phosphatase binding;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031730,molecular_function CCR5 chemokine receptor binding;GO:0035556,biological_process intracellular signal transduction;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038110,biological_process interleukin-2-mediated signaling pathway;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045087,biological_process innate immune response;GO:0046677,biological_process response to antibiotic;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:1903672,biological_process positive regulation of sprouting angiogenesis	JAK1; Janus kinase 1 [EC:2.7.10.2]; K11217	Janus kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:6190]
ENSG00000105711	17.06	17.79	18.29	14.68	14.19	14.83	0.292207263956432	4.03805380311145	0.00190457770940304	0.0386299397170261	19:35030465-35040449:+	SCN1B	44;GO:0001518,cellular_component voltage-gated sodium channel complex;GO:0002028,biological_process regulation of sodium ion transport;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005248,molecular_function voltage-gated sodium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0007155,biological_process cell adhesion;GO:0007268,biological_process chemical synaptic transmission;GO:0007411,biological_process axon guidance;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017080,molecular_function sodium channel regulator activity;GO:0019227,biological_process neuronal action potential propagation;GO:0019871,molecular_function sodium channel inhibitor activity;GO:0021966,biological_process corticospinal neuron axon guidance;GO:0030315,cellular_component T-tubule;GO:0033268,cellular_component node of Ranvier;GO:0034706,cellular_component sodium channel complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0040011,biological_process locomotion;GO:0046684,biological_process response to pyrethroid;GO:0051899,biological_process membrane depolarization;GO:0060048,biological_process cardiac muscle contraction;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060307,biological_process regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060371,biological_process regulation of atrial cardiac muscle cell membrane depolarization;GO:0061337,biological_process cardiac conduction;GO:0065009,biological_process regulation of molecular function;GO:0086002,biological_process cardiac muscle cell action potential involved in contraction;GO:0086006,molecular_function voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0086012,biological_process membrane depolarization during cardiac muscle cell action potential;GO:0086047,biological_process membrane depolarization during Purkinje myocyte cell action potential;GO:0086062,molecular_function voltage-gated sodium channel activity involved in Purkinje myocyte action potential;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	SCN1B; voltage-gated sodium channel type I beta; K04845	sodium voltage-gated channel beta subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:10586]
ENSG00000136111	5.35	6.55	5.67	4.50	5.20	4.35	0.32811244616053	4.36226326151283	0.00192988070643214	0.0390792972413411	13:75284664-75482114:-	TBC1D4	17;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0016192,biological_process vesicle-mediated transport;GO:0017137,molecular_function Rab GTPase binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031338,biological_process regulation of vesicle fusion;GO:0031339,biological_process negative regulation of vesicle fusion;GO:0031982,cellular_component vesicle;GO:0032869,biological_process cellular response to insulin stimulus;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:19165]
ENSG00000262664	38.37	39.29	37.29	30.78	32.41	33.77	0.254299641732975	4.59531084139177	0.00194732028546491	0.0393682193867686	17:2041935-2043430:+	OVCA2	4;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016787,molecular_function hydrolase activity;GO:0032526,biological_process response to retinoic acid	NA	OVCA2%2C serine hydrolase domain containing [Source:HGNC Symbol%3BAcc:HGNC:24203]
ENSG00000138061	29.00	32.56	30.23	23.30	29.05	24.09	0.273801878526439	5.51547402497833	0.00195486171700471	0.0394564203141129	2:38066972-38109902:-	CYP1B1	53;GO:0001525,biological_process angiogenesis;GO:0002930,biological_process trabecular meshwork development;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006725,biological_process cellular aromatic compound metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0007155,biological_process cell adhesion;GO:0007601,biological_process visual perception;GO:0008202,biological_process steroid metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0009404,biological_process toxin metabolic process;GO:0009636,biological_process response to toxic substance;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016125,biological_process sterol metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016712,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0019369,biological_process arachidonic acid metabolic process;GO:0019373,biological_process epoxygenase P450 pathway;GO:0019825,molecular_function oxygen binding;GO:0020037,molecular_function heme binding;GO:0030199,biological_process collagen fibril organization;GO:0030336,biological_process negative regulation of cell migration;GO:0031090,cellular_component organelle membrane;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0033629,biological_process negative regulation of cell adhesion mediated by integrin;GO:0042572,biological_process retinol metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043542,biological_process endothelial cell migration;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0046466,biological_process membrane lipid catabolic process;GO:0046872,molecular_function metal ion binding;GO:0048514,biological_process blood vessel morphogenesis;GO:0055114,biological_process oxidation-reduction process;GO:0061298,biological_process retina vasculature development in camera-type eye;GO:0061304,biological_process retinal blood vessel morphogenesis;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070330,molecular_function aromatase activity;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071603,biological_process endothelial cell-cell adhesion;GO:0097267,biological_process omega-hydroxylase P450 pathway;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	CYP1B1; cytochrome P450 family 1 subfamily B polypeptide 1 [EC:1.14.14.1]; K07410	cytochrome P450 family 1 subfamily B member 1 [Source:HGNC Symbol%3BAcc:HGNC:2597]
ENSG00000189190	8.18	8.82	7.31	6.43	6.44	6.72	0.315612773543151	3.9944973299196	0.00196017688810866	0.0394994735585922	19:52764194-52786791:-	ZNF600	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 600 [Source:HGNC Symbol%3BAcc:HGNC:30951]
ENSG00000185522	15.83	16.03	19.37	13.67	11.00	15.55	0.361241075965384	4.95310551856047	0.00197335278176704	0.0397005317343181	11:554854-560779:-	LMNTD2	1;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome	NA	lamin tail domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28561]
ENSG00000115468	2.93	3.20	1.87	3.81	4.57	5.09	-0.75622522661298	1.50384820542171	0.00198561645089146	0.0398826165128086	2:232606056-232682781:+	EFHD1	7;GO:0005509,molecular_function calcium ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0031175,biological_process neuron projection development;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	EF-hand domain family member D1 [Source:HGNC Symbol%3BAcc:HGNC:29556]
ENSG00000146674	1025.91	806.16	1083.02	829.81	614.45	833.90	0.367544731035734	9.70647846119494	0.00199354655254279	0.0399772105924292	7:45912244-45921874:-	IGFBP3	36;GO:0001558,biological_process regulation of cell growth;GO:0001649,biological_process osteoblast differentiation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001968,molecular_function fibronectin binding;GO:0005515,molecular_function protein binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0008160,molecular_function protein tyrosine phosphatase activator activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009968,biological_process negative regulation of signal transduction;GO:0010906,biological_process regulation of glucose metabolic process;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016942,cellular_component insulin-like growth factor binding protein complex;GO:0019838,molecular_function growth factor binding;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0031995,molecular_function insulin-like growth factor II binding;GO:0040008,biological_process regulation of growth;GO:0042567,cellular_component insulin-like growth factor ternary complex;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043567,biological_process regulation of insulin-like growth factor receptor signaling pathway;GO:0043568,biological_process positive regulation of insulin-like growth factor receptor signaling pathway;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0044342,biological_process type B pancreatic cell proliferation;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0046872,molecular_function metal ion binding;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0070062,cellular_component extracellular exosome	IGFBP3; insulin-like growth factor-binding protein 3; K10138	insulin like growth factor binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:5472]
ENSG00000144824	34.47	35.82	37.63	39.83	44.41	41.40	-0.207563748406111	7.43553653276782	0.00199724163205639	0.0399867102882516	3:111732496-111976517:+	PHLDB2	20;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0010470,biological_process regulation of gastrulation;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031252,cellular_component cell leading edge;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045180,cellular_component basal cortex;GO:0045184,biological_process establishment of protein localization;GO:0045296,molecular_function cadherin binding;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:1903690,biological_process negative regulation of wound healing, spreading of epidermal cells;GO:1904261,biological_process positive regulation of basement membrane assembly involved in embryonic body morphogenesis	NA	pleckstrin homology like domain family B member 2 [Source:HGNC Symbol%3BAcc:HGNC:29573]
ENSG00000137449	13.35	13.36	13.39	10.71	12.36	11.39	0.23067252844139	5.27783233781678	0.00203699625270708	0.0406876781616065	4:15002673-15070153:+	CPEB2	25;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0043005,cellular_component neuron projection;GO:0043022,molecular_function ribosome binding;GO:0043023,molecular_function ribosomal large subunit binding;GO:0043024,molecular_function ribosomal small subunit binding;GO:0045182,molecular_function translation regulator activity;GO:0045202,cellular_component synapse;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0071456,biological_process cellular response to hypoxia;GO:1900248,biological_process negative regulation of cytoplasmic translational elongation;GO:1990124,cellular_component messenger ribonucleoprotein complex;GO:2000766,biological_process negative regulation of cytoplasmic translation	NA	cytoplasmic polyadenylation element binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:21745]
ENSG00000124370	17.12	19.91	15.61	13.05	13.21	13.05	0.420840010851783	3.03182143439911	0.00204170304646021	0.0406876781616065	2:71109683-71130239:-	MCEE	8;GO:0004493,molecular_function methylmalonyl-CoA epimerase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0016853,molecular_function isomerase activity;GO:0019626,biological_process short-chain fatty acid catabolic process;GO:0046491,biological_process L-methylmalonyl-CoA metabolic process;GO:0046872,molecular_function metal ion binding	MCEE, epi; methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1]; K05606	methylmalonyl-CoA epimerase [Source:HGNC Symbol%3BAcc:HGNC:16732]
ENSG00000172893	97.13	123.16	90.90	77.95	95.12	72.71	0.351185721031065	7.28155999864024	0.00204492062631547	0.0406876781616065	11:71428192-71452868:-	DHCR7	30;GO:0001568,biological_process blood vessel development;GO:0005640,cellular_component nuclear outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0009791,biological_process post-embryonic development;GO:0009918,molecular_function sterol delta7 reductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016132,biological_process brassinosteroid biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016628,molecular_function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0030154,biological_process cell differentiation;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030324,biological_process lung development;GO:0033489,biological_process cholesterol biosynthetic process via desmosterol;GO:0033490,biological_process cholesterol biosynthetic process via lathosterol;GO:0035264,biological_process multicellular organism growth;GO:0042127,biological_process regulation of cell proliferation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0047598,molecular_function 7-dehydrocholesterol reductase activity;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process	DHCR7; 7-dehydrocholesterol reductase [EC:1.3.1.21]; K00213	7-dehydrocholesterol reductase [Source:HGNC Symbol%3BAcc:HGNC:2860]
ENSG00000228253	3602.61	4221.28	4207.53	3289.60	3635.61	3410.77	0.230929477217111	9.57230093344221	0.00204536463166378	0.0406876781616065	MT:8365-8572:+	MT-ATP8	19;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0031966,cellular_component mitochondrial membrane;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0055093,biological_process response to hyperoxia	ATPeF08, MTATP8, ATP8; F-type H+-transporting ATPase subunit 8; K02125	mitochondrially encoded ATP synthase 8 [Source:HGNC Symbol%3BAcc:HGNC:7415]
ENSG00000124602	7.64	7.07	7.86	4.63	6.30	6.20	0.413201993773999	3.38250953863761	0.00208237840821884	0.0413023961801314	6:41026910-41039217:-	UNC5CL	8;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330,biological_process positive regulation of JNK cascade	NA	unc-5 family C-terminal like [Source:HGNC Symbol%3BAcc:HGNC:21203]
ENSG00000141682	93.13	73.55	87.67	111.76	93.87	108.23	-0.285729410057723	5.28372451332235	0.0020852919314329	0.0413023961801314	18:59899947-59904306:+	PMAIP1	32;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001844,biological_process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010498,biological_process proteasomal protein catabolic process;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0010917,biological_process negative regulation of mitochondrial membrane potential;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0042149,biological_process cellular response to glucose starvation;GO:0042981,biological_process regulation of apoptotic process;GO:0043029,biological_process T cell homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043331,biological_process response to dsRNA;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0051607,biological_process defense response to virus;GO:0071456,biological_process cellular response to hypoxia;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1; K10131	phorbol-12-myristate-13-acetate-induced protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9108]
ENSG00000059377	15.94	17.22	14.88	13.01	13.18	14.14	0.258323609225849	4.78424032371062	0.00208624848182892	0.0413023961801314	7:139777050-140020325:+	TBXAS1	26;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0004497,molecular_function monooxygenase activity;GO:0004796,molecular_function thromboxane-A synthase activity;GO:0005506,molecular_function iron ion binding;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006690,biological_process icosanoid metabolic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016853,molecular_function isomerase activity;GO:0019371,biological_process cyclooxygenase pathway;GO:0020037,molecular_function heme binding;GO:0030644,biological_process cellular chloride ion homeostasis;GO:0036134,molecular_function 12-hydroxyheptadecatrienoic acid synthase activity;GO:0045471,biological_process response to ethanol;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070542,biological_process response to fatty acid	TBXAS1, CYP5A; thromboxane-A synthase [EC:5.3.99.5]; K01832	thromboxane A synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:11609]
ENSG00000151388	3.30	4.28	3.04	2.49	3.08	2.16	0.461464276055263	3.88861640278082	0.00210058991146298	0.0415200996353344	5:33523534-33892192:-	ADAMTS12	24;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0007160,biological_process cell-matrix adhesion;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0030167,biological_process proteoglycan catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0050727,biological_process regulation of inflammatory response;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071773,biological_process cellular response to BMP stimulus;GO:1901509,biological_process regulation of endothelial tube morphogenesis;GO:1902203,biological_process negative regulation of hepatocyte growth factor receptor signaling pathway;GO:1902548,biological_process negative regulation of cellular response to vascular endothelial growth factor stimulus;GO:2001113,biological_process negative regulation of cellular response to hepatocyte growth factor stimulus	NA	ADAM metallopeptidase with thrombospondin type 1 motif 12 [Source:HGNC Symbol%3BAcc:HGNC:14605]
ENSG00000067064	66.77	82.24	54.27	47.19	60.44	48.30	0.391882536274283	5.88730352770923	0.00212045801730386	0.0418461770569043	10:1039907-1049170:-	IDI1	16;GO:0004452,molecular_function isopentenyl-diphosphate delta-isomerase activity;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0009240,biological_process isopentenyl diphosphate biosynthetic process;GO:0016126,biological_process sterol biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0016853,molecular_function isomerase activity;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0050992,biological_process dimethylallyl diphosphate biosynthetic process	idi, IDI; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]; K01823	isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol%3BAcc:HGNC:5387]
ENSG00000163918	30.00	29.02	31.60	37.85	35.35	34.32	-0.231850351388627	5.17880730043601	0.0021440637682146	0.0422448627854728	3:186789879-186807058:-	RFC4	25;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005663,cellular_component DNA replication factor C complex;GO:0006260,biological_process DNA replication;GO:0006271,biological_process DNA strand elongation involved in DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0019899,molecular_function enzyme binding;GO:0019985,biological_process translesion synthesis;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0070987,biological_process error-free translesion synthesis;GO:1900264,biological_process positive regulation of DNA-directed DNA polymerase activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RFC2_4; replication factor C subunit 2/4; K10755	replication factor C subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:9972]
ENSG00000169071	3.72	2.37	3.46	2.13	1.66	2.63	0.592750353565633	3.04514741496098	0.00217030810996755	0.0426941910761128	9:91563090-91950162:-	ROR2	57;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001502,biological_process cartilage condensation;GO:0001756,biological_process somitogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007224,biological_process smoothened signaling pathway;GO:0007254,biological_process JNK cascade;GO:0007275,biological_process multicellular organism development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0014002,biological_process astrocyte development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017147,molecular_function Wnt-protein binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030282,biological_process bone mineralization;GO:0030335,biological_process positive regulation of cell migration;GO:0030425,cellular_component dendrite;GO:0030509,biological_process BMP signaling pathway;GO:0030538,biological_process embryonic genitalia morphogenesis;GO:0030539,biological_process male genitalia development;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0042472,biological_process inner ear morphogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043025,cellular_component neuronal cell body;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045165,biological_process cell fate commitment;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060395,biological_process SMAD protein signal transduction;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1900020,biological_process positive regulation of protein kinase C activity;GO:1904929,molecular_function coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway;GO:1905517,biological_process macrophage migration	ROR2, NTRKR2; receptor tyrosine kinase-like orphan receptor 2 [EC:2.7.10.1]; K05123	receptor tyrosine kinase like orphan receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:10257]
ENSG00000132471	121.78	132.50	128.67	110.87	115.85	109.08	0.200310412314324	6.85491129357136	0.00218016208822849	0.0428201772170574	17:75845698-75856507:-	WBP2	10;GO:0000790,cellular_component nuclear chromatin;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0031490,molecular_function chromatin DNA binding;GO:0045184,biological_process establishment of protein localization;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0071391,biological_process cellular response to estrogen stimulus;GO:0071442,biological_process positive regulation of histone H3-K14 acetylation	NA	WW domain binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:12738]
ENSG00000138152	0.88	0.69	0.58	1.58	0.85	1.95	-1.00098934099748	0.87541883393513	0.00219113453064301	0.0429676981498762	10:122271305-122338162:+	BTBD16	2;GO:0000151,cellular_component ubiquitin ligase complex;GO:0005634,cellular_component nucleus	NA	BTB domain containing 16 [Source:HGNC Symbol%3BAcc:HGNC:26340]
ENSG00000065427	93.57	94.44	101.19	115.42	106.86	111.77	-0.195989757950576	7.67252039877436	0.00219614208412183	0.042997967965622	16:75627473-75648643:-	KARS	42;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0002276,biological_process basophil activation involved in immune response;GO:0002741,biological_process positive regulation of cytokine secretion involved in immune response;GO:0003676,molecular_function nucleic acid binding;GO:0003877,molecular_function ATP adenylyltransferase activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004824,molecular_function lysine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006430,biological_process lysyl-tRNA aminoacylation;GO:0008033,biological_process tRNA processing;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010165,biological_process response to X-ray;GO:0010759,biological_process positive regulation of macrophage chemotaxis;GO:0015966,biological_process diadenosine tetraphosphate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016597,molecular_function amino acid binding;GO:0016874,molecular_function ligase activity;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043032,biological_process positive regulation of macrophage activation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1905050,biological_process positive regulation of metallopeptidase activity	KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]; K04567	lysyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:6215]
ENSG00000072657	0.46	0.62	0.53	0.22	0.22	0.34	1.01139641394565	0.439791727144193	0.00221852026282924	0.043338808915822	12:72087265-72670757:+	TRHDE	18;GO:0004177,molecular_function aminopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008217,biological_process regulation of blood pressure;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome	NA	thyrotropin releasing hormone degrading enzyme [Source:HGNC Symbol%3BAcc:HGNC:30748]
ENSG00000102710	20.74	19.31	20.69	16.59	18.32	17.93	0.215163940903066	5.63100695423464	0.0022205335108727	0.043338808915822	13:37009311-37059713:-	SUPT20H	10;GO:0000124,cellular_component SAGA complex;GO:0001650,cellular_component fibrillar center;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006914,biological_process autophagy;GO:0007275,biological_process multicellular organism development;GO:0007369,biological_process gastrulation;GO:0070461,cellular_component SAGA-type complex;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	SPT20 homolog%2C SAGA complex component [Source:HGNC Symbol%3BAcc:HGNC:20596]
ENSG00000125966	22.85	24.60	21.60	27.51	33.08	24.97	-0.299062834796928	5.64451638469844	0.00224274870408863	0.0437036729416831	20:35226653-35277000:+	MMP24	26;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0007155,biological_process cell adhesion;GO:0008047,molecular_function enzyme activator activity;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0010001,biological_process glial cell differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031012,cellular_component extracellular matrix;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043085,biological_process positive regulation of catalytic activity;GO:0044331,biological_process cell-cell adhesion mediated by cadherin;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain;GO:0070062,cellular_component extracellular exosome;GO:0097150,biological_process neuronal stem cell population maintenance;GO:0098742,biological_process cell-cell adhesion via plasma-membrane adhesion molecules	MMP24; matrix metalloproteinase-24 (membrane-inserted) [EC:3.4.24.-]; K08002	matrix metallopeptidase 24 [Source:HGNC Symbol%3BAcc:HGNC:7172]
ENSG00000002330	35.49	36.58	28.82	26.23	29.13	26.48	0.309882552411653	4.61450293026413	0.00225804900662548	0.0439328562997524	11:64269829-64284704:-	BAD	80;GO:0001666,biological_process response to hypoxia;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001844,biological_process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006007,biological_process glucose catabolic process;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007283,biological_process spermatogenesis;GO:0008283,biological_process cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0009725,biological_process response to hormone;GO:0009749,biological_process response to glucose;GO:0010033,biological_process response to organic substance;GO:0010508,biological_process positive regulation of autophagy;GO:0010918,biological_process positive regulation of mitochondrial membrane potential;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0019050,biological_process suppression by virus of host apoptotic process;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0021987,biological_process cerebral cortex development;GO:0030346,molecular_function protein phosphatase 2B binding;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032355,biological_process response to estradiol;GO:0032570,biological_process response to progesterone;GO:0033133,biological_process positive regulation of glucokinase activity;GO:0033574,biological_process response to testosterone;GO:0034201,biological_process response to oleic acid;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042593,biological_process glucose homeostasis;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043200,biological_process response to amino acid;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043281,biological_process regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043422,molecular_function protein kinase B binding;GO:0044342,biological_process type B pancreatic cell proliferation;GO:0045471,biological_process response to ethanol;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0045862,biological_process positive regulation of proteolysis;GO:0045918,biological_process negative regulation of cytolysis;GO:0046031,biological_process ADP metabolic process;GO:0046034,biological_process ATP metabolic process;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0046931,biological_process pore complex assembly;GO:0046982,molecular_function protein heterodimerization activity;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051384,biological_process response to glucocorticoid;GO:0051592,biological_process response to calcium ion;GO:0060139,biological_process positive regulation of apoptotic process by virus;GO:0060154,biological_process cellular process regulating host cell cycle in response to virus;GO:0071247,biological_process cellular response to chromate;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071316,biological_process cellular response to nicotine;GO:0071396,biological_process cellular response to lipid;GO:0071456,biological_process cellular response to hypoxia;GO:0071889,molecular_function 14-3-3 protein binding;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1901216,biological_process positive regulation of neuron death;GO:1902220,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:2000078,biological_process positive regulation of type B pancreatic cell development;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BAD; Bcl-2-antagonist of cell death; K02158	BCL2 associated agonist of cell death [Source:HGNC Symbol%3BAcc:HGNC:936]
ENSG00000120915	0.64	0.23	0.84	1.12	0.96	1.44	-0.972084451474385	0.717357478005521	0.00227537084224048	0.0441680836436247	8:27490778-27545564:+	EPHX2	33;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004301,molecular_function epoxide hydrolase activity;GO:0005102,molecular_function receptor binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006954,biological_process inflammatory response;GO:0008152,biological_process metabolic process;GO:0008217,biological_process regulation of blood pressure;GO:0009636,biological_process response to toxic substance;GO:0010628,biological_process positive regulation of gene expression;GO:0015643,molecular_function toxic substance binding;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017144,biological_process drug metabolic process;GO:0019373,biological_process epoxygenase P450 pathway;GO:0019439,biological_process aromatic compound catabolic process;GO:0033885,molecular_function 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity;GO:0042577,molecular_function lipid phosphatase activity;GO:0042632,biological_process cholesterol homeostasis;GO:0042803,molecular_function protein homodimerization activity;GO:0046272,biological_process stilbene catabolic process;GO:0046839,biological_process phospholipid dephosphorylation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:0097755,biological_process positive regulation of blood vessel diameter	EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]; K08726	epoxide hydrolase 2 [Source:HGNC Symbol%3BAcc:HGNC:3402]
ENSG00000213445	4.07	4.68	4.31	3.66	3.32	3.35	0.340634397945813	3.61827896044321	0.00227725558140013	0.0441680836436247	11:65638096-65650930:+	SIPA1	21;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007010,biological_process cytoskeleton organization;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0030133,cellular_component transport vesicle;GO:0030308,biological_process negative regulation of cell growth;GO:0035556,biological_process intracellular signal transduction;GO:0042631,biological_process cellular response to water deprivation;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045786,biological_process negative regulation of cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	SIPA1; signal-induced proliferation-associated gene 1; K08013	signal-induced proliferation-associated 1 [Source:HGNC Symbol%3BAcc:HGNC:10885]
ENSG00000125538	5.78	6.04	6.38	2.23	4.89	4.27	0.685935702486489	2.03840825410805	0.00228987557959567	0.0442125456710508	2:112829750-112836903:-	IL1B	96;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0001660,biological_process fever generation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002711,biological_process positive regulation of T cell mediated immunity;GO:0005125,molecular_function cytokine activity;GO:0005149,molecular_function interleukin-1 receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007566,biological_process embryo implantation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009743,biological_process response to carbohydrate;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010628,biological_process positive regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010829,biological_process negative regulation of glucose transport;GO:0014805,biological_process smooth muscle adaptation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019904,molecular_function protein domain specific binding;GO:0030141,cellular_component secretory granule;GO:0030213,biological_process hyaluronan biosynthetic process;GO:0030335,biological_process positive regulation of cell migration;GO:0030593,biological_process neutrophil chemotaxis;GO:0030730,biological_process sequestering of triglyceride;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031622,biological_process positive regulation of fever generation;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0031982,cellular_component vesicle;GO:0032308,biological_process positive regulation of prostaglandin secretion;GO:0032496,biological_process response to lipopolysaccharide;GO:0032611,biological_process interleukin-1 beta production;GO:0032725,biological_process positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0033198,biological_process response to ATP;GO:0034116,biological_process positive regulation of heterotypic cell-cell adhesion;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035234,biological_process ectopic germ cell programmed cell death;GO:0035505,biological_process positive regulation of myosin light chain kinase activity;GO:0035690,biological_process cellular response to drug;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043491,biological_process protein kinase B signaling;GO:0045080,biological_process positive regulation of chemokine biosynthetic process;GO:0045086,biological_process positive regulation of interleukin-2 biosynthetic process;GO:0045410,biological_process positive regulation of interleukin-6 biosynthetic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045833,biological_process negative regulation of lipid metabolic process;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0050691,biological_process regulation of defense response to virus by host;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050796,biological_process regulation of insulin secretion;GO:0050805,biological_process negative regulation of synaptic transmission;GO:0050900,biological_process leukocyte migration;GO:0050995,biological_process negative regulation of lipid catabolic process;GO:0050996,biological_process positive regulation of lipid catabolic process;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051781,biological_process positive regulation of cell division;GO:0060355,biological_process positive regulation of cell adhesion molecule production;GO:0060559,biological_process positive regulation of calcidiol 1-monooxygenase activity;GO:0070062,cellular_component extracellular exosome;GO:0070164,biological_process negative regulation of adiponectin secretion;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0070487,biological_process monocyte aggregation;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071310,biological_process cellular response to organic substance;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071639,biological_process positive regulation of monocyte chemotactic protein-1 production;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1903140,biological_process regulation of establishment of endothelial barrier;GO:2000778,biological_process positive regulation of interleukin-6 secretion;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IL1B; interleukin 1 beta; K04519	interleukin 1 beta [Source:HGNC Symbol%3BAcc:HGNC:5992]
ENSG00000185551	67.16	69.98	69.25	56.40	61.21	63.15	0.202063630933916	6.37627713171616	0.00229024458986839	0.0442125456710508	15:96325937-96340263:+	NR2F2	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001701,biological_process in utero embryonic development;GO:0001764,biological_process neuron migration;GO:0001893,biological_process maternal placenta development;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0001945,biological_process lymph vessel development;GO:0001972,molecular_function retinoic acid binding;GO:0003084,biological_process positive regulation of systemic arterial blood pressure;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007519,biological_process skeletal muscle tissue development;GO:0008270,molecular_function zinc ion binding;GO:0009566,biological_process fertilization;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009956,biological_process radial pattern formation;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0030900,biological_process forebrain development;GO:0032355,biological_process response to estradiol;GO:0042803,molecular_function protein homodimerization activity;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048514,biological_process blood vessel morphogenesis;GO:0060173,biological_process limb development;GO:0060674,biological_process placenta blood vessel development;GO:0060707,biological_process trophoblast giant cell differentiation;GO:0060849,biological_process regulation of transcription involved in lymphatic endothelial cell fate commitment	NA	nuclear receptor subfamily 2 group F member 2 [Source:HGNC Symbol%3BAcc:HGNC:7976]
ENSG00000114388	17.08	15.91	17.48	14.04	13.89	14.05	0.28202417007721	4.1490063203477	0.00229109690564343	0.0442125456710508	3:50347329-50351091:-	NPRL2	15;GO:0004672,molecular_function protein kinase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006468,biological_process protein phosphorylation;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0010508,biological_process positive regulation of autophagy;GO:0016020,cellular_component membrane;GO:0032007,biological_process negative regulation of TOR signaling;GO:0033673,biological_process negative regulation of kinase activity;GO:0034198,biological_process cellular response to amino acid starvation;GO:0043547,biological_process positive regulation of GTPase activity;GO:1990130,cellular_component Iml1 complex;GO:2000785,biological_process regulation of autophagosome assembly	NA	NPR2 like%2C GATOR1 complex subunit [Source:HGNC Symbol%3BAcc:HGNC:24969]
ENSG00000101444	84.09	96.52	84.16	105.84	100.89	103.25	-0.21800424791318	6.95799070464232	0.0022937951673372	0.0442125456710508	20:34280267-34311802:-	AHCY	22;GO:0000096,biological_process sulfur amino acid metabolic process;GO:0001666,biological_process response to hypoxia;GO:0002439,biological_process chronic inflammatory response to antigenic stimulus;GO:0004013,molecular_function adenosylhomocysteinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006730,biological_process one-carbon metabolic process;GO:0007584,biological_process response to nutrient;GO:0016787,molecular_function hydrolase activity;GO:0019510,biological_process S-adenosylhomocysteine catabolic process;GO:0030554,molecular_function adenyl nucleotide binding;GO:0032259,biological_process methylation;GO:0033353,biological_process S-adenosylmethionine cycle;GO:0042470,cellular_component melanosome;GO:0042745,biological_process circadian sleep/wake cycle;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0051287,molecular_function NAD binding;GO:0070062,cellular_component extracellular exosome;GO:0071268,biological_process homocysteine biosynthetic process	E3.3.1.1, ahcY; adenosylhomocysteinase [EC:3.3.1.1]; K01251	adenosylhomocysteinase [Source:HGNC Symbol%3BAcc:HGNC:343]
ENSG00000172262	25.39	23.61	25.70	28.94	29.06	28.55	-0.197565433739751	5.85563853139982	0.00229928953695588	0.0442497380189664	5:43065175-43192021:+	ZNF131	12;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 131 [Source:HGNC Symbol%3BAcc:HGNC:12915]
ENSG00000164176	60.62	62.58	63.12	54.54	53.72	56.16	0.191478308012339	6.39826276800548	0.00234820599226027	0.0451211779905987	5:83940553-84384793:-	EDIL3	10;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0031012,cellular_component extracellular matrix;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	NA	EGF like repeats and discoidin domains 3 [Source:HGNC Symbol%3BAcc:HGNC:3173]
ENSG00000161800	37.45	40.17	34.07	41.64	48.41	43.06	-0.243458558060246	6.38636641551395	0.00236170193852073	0.045310365012145	12:49976922-50033136:-	RACGAP1	50;GO:0000281,biological_process mitotic cytokinesis;GO:0000915,biological_process actomyosin contractile ring assembly;GO:0001669,cellular_component acrosomal vesicle;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007405,biological_process neuroblast proliferation;GO:0008017,molecular_function microtubule binding;GO:0008272,biological_process sulfate transport;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019901,molecular_function protein kinase binding;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032154,cellular_component cleavage furrow;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035556,biological_process intracellular signal transduction;GO:0043014,molecular_function alpha-tubulin binding;GO:0043015,molecular_function gamma-tubulin binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045995,biological_process regulation of embryonic development;GO:0046872,molecular_function metal ion binding;GO:0048487,molecular_function beta-tubulin binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051233,cellular_component spindle midzone;GO:0051256,biological_process mitotic spindle midzone assembly;GO:0051301,biological_process cell division;GO:0051988,biological_process regulation of attachment of spindle microtubules to kinetochore;GO:0070062,cellular_component extracellular exosome;GO:0072686,cellular_component mitotic spindle;GO:0097149,cellular_component centralspindlin complex	NA	Rac GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9804]
ENSG00000095383	45.23	52.35	44.86	39.56	42.66	40.49	0.224946407259246	6.94396985499736	0.00238016498589281	0.0455941172374806	9:98198998-98255721:-	TBC1D2	14;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0030054,cellular_component cell junction;GO:0031338,biological_process regulation of vesicle fusion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 2 [Source:HGNC Symbol%3BAcc:HGNC:18026]
ENSG00000165895	4.52	4.71	4.02	3.13	3.26	3.81	0.38194006483781	3.39122414210158	0.00238583703040605	0.0456323498589066	11:100687652-100991937:+	ARHGAP42	8;GO:0003085,biological_process negative regulation of systemic arterial blood pressure;GO:0005096,molecular_function GTPase activator activity;GO:0005575,cellular_component cellular_component;GO:0007165,biological_process signal transduction;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0090630,biological_process activation of GTPase activity;GO:1904694,biological_process negative regulation of vascular smooth muscle contraction	NA	Rho GTPase activating protein 42 [Source:HGNC Symbol%3BAcc:HGNC:26545]
ENSG00000171766	1.65	2.09	1.26	2.57	3.25	2.41	-0.726160822600253	1.57401309907613	0.00240416324774737	0.0457697304695095	15:45361123-45402327:-	GATM	14;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006600,biological_process creatine metabolic process;GO:0006601,biological_process creatine biosynthetic process;GO:0007275,biological_process multicellular organism development;GO:0007611,biological_process learning or memory;GO:0014889,biological_process muscle atrophy;GO:0015067,molecular_function amidinotransferase activity;GO:0015068,molecular_function glycine amidinotransferase activity;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0070062,cellular_component extracellular exosome	GATM; glycine amidinotransferase [EC:2.1.4.1]; K00613	glycine amidinotransferase [Source:HGNC Symbol%3BAcc:HGNC:4175]
ENSG00000135253	17.01	19.21	20.45	12.91	18.20	14.43	0.32735487974528	6.40870467976551	0.00240424573384944	0.0457697304695095	7:128862450-128910719:-	KCP	3;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005615,cellular_component extracellular space;GO:0030513,biological_process positive regulation of BMP signaling pathway	NA	kielin/chordin-like protein [Source:HGNC Symbol%3BAcc:HGNC:17585]
ENSG00000196420	7.16	6.23	4.53	9.77	8.79	12.48	-0.782522756301358	1.28077015256205	0.00240611086482285	0.0457697304695095	1:153537146-153541765:-	S100A5	8;GO:0005507,molecular_function copper ion binding;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0008270,molecular_function zinc ion binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0046872,molecular_function metal ion binding;GO:0046914,molecular_function transition metal ion binding	NA	S100 calcium binding protein A5 [Source:HGNC Symbol%3BAcc:HGNC:10495]
ENSG00000119986	11.53	11.49	14.19	18.68	15.65	17.54	-0.462097783551542	2.75317851211854	0.00240776879050912	0.0457697304695095	10:97677423-97687323:-	AVPI1	3;GO:0000187,biological_process activation of MAPK activity;GO:0005515,molecular_function protein binding;GO:0007049,biological_process cell cycle	NA	arginine vasopressin induced 1 [Source:HGNC Symbol%3BAcc:HGNC:30898]
ENSG00000198712	14641.43	15432.22	15388.04	13612.08	13881.29	12911.38	0.181840229787847	13.2520266617785	0.0024267431097661	0.0460598810726706	MT:7585-8269:+	MT-CO2	20;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0007595,biological_process lactation;GO:0009409,biological_process response to cold;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0022900,biological_process electron transport chain;GO:0042773,biological_process ATP synthesis coupled electron transport;GO:0045277,cellular_component respiratory chain complex IV;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	COX2; cytochrome c oxidase subunit 2; K02261	mitochondrially encoded cytochrome c oxidase II [Source:HGNC Symbol%3BAcc:HGNC:7421]
ENSG00000049860	111.19	114.49	110.55	96.22	103.45	98.12	0.186583608093277	7.47972469096409	0.00243504670448209	0.0461469232713529	5:74640022-74722647:+	HEXB	47;GO:0001501,biological_process skeletal system development;GO:0001669,cellular_component acrosomal vesicle;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004563,molecular_function beta-N-acetylhexosaminidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006689,biological_process ganglioside catabolic process;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007040,biological_process lysosome organization;GO:0007338,biological_process single fertilization;GO:0007341,biological_process penetration of zona pellucida;GO:0007605,biological_process sensory perception of sound;GO:0007626,biological_process locomotory behavior;GO:0008049,biological_process male courtship behavior;GO:0008152,biological_process metabolic process;GO:0008360,biological_process regulation of cell shape;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019915,biological_process lipid storage;GO:0019953,biological_process sexual reproduction;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0030214,biological_process hyaluronan catabolic process;GO:0031323,biological_process regulation of cellular metabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0042340,biological_process keratan sulfate catabolic process;GO:0042552,biological_process myelination;GO:0042582,cellular_component azurophil granule;GO:0042803,molecular_function protein homodimerization activity;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043615,biological_process astrocyte cell migration;GO:0044267,biological_process cellular protein metabolic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048477,biological_process oogenesis;GO:0050885,biological_process neuromuscular process controlling balance;GO:0050905,biological_process neuromuscular process;GO:0070062,cellular_component extracellular exosome;GO:0102148,molecular_function N-acetyl-beta-D-galactosaminidase activity	HEXA_B; hexosaminidase [EC:3.2.1.52]; K12373	hexosaminidase subunit beta [Source:HGNC Symbol%3BAcc:HGNC:4879]
ENSG00000145075	3.37	2.83	3.20	2.21	2.56	2.40	0.410594350610235	3.01690512765758	0.00243906051849453	0.0461525277684033	3:180602857-180871005:-	CCDC39	20;GO:0001947,biological_process heart looping;GO:0003341,biological_process cilium movement;GO:0003356,biological_process regulation of cilium beat frequency;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0030317,biological_process sperm motility;GO:0030324,biological_process lung development;GO:0035469,biological_process determination of pancreatic left/right asymmetry;GO:0036159,biological_process inner dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0060285,biological_process cilium-dependent cell motility;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry;GO:0070286,biological_process axonemal dynein complex assembly;GO:0071907,biological_process determination of digestive tract left/right asymmetry;GO:0071910,biological_process determination of liver left/right asymmetry	NA	coiled-coil domain containing 39 [Source:HGNC Symbol%3BAcc:HGNC:25244]
ENSG00000204161	1.77	2.16	2.10	0.98	0.90	1.17	0.970163416047527	0.492561989025546	0.00244633997522404	0.0462198144786241	10:49154724-49188585:-	C10orf128	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 10 open reading frame 128 [Source:HGNC Symbol%3BAcc:HGNC:27274]
ENSG00000187688	0.74	0.72	0.52	0.34	0.32	0.32	1.0041230778512	0.398507742681651	0.00246514294820207	0.0465042848267969	17:16415541-16437003:+	TRPV2	26;GO:0005216,molecular_function ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007600,biological_process sensory perception;GO:0009266,biological_process response to temperature stimulus;GO:0009408,biological_process response to heat;GO:0009986,cellular_component cell surface;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030424,cellular_component axon;GO:0032584,cellular_component growth cone membrane;GO:0042470,cellular_component melanosome;GO:0044295,cellular_component axonal growth cone;GO:0044297,cellular_component cell body;GO:0045773,biological_process positive regulation of axon extension;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0090280,biological_process positive regulation of calcium ion import	TRPV2; transient receptor potential cation channel subfamily V member 2; K04971	transient receptor potential cation channel subfamily V member 2 [Source:HGNC Symbol%3BAcc:HGNC:18082]
ENSG00000164733	373.67	385.26	384.87	345.98	337.69	338.50	0.173830117723808	8.52745891620769	0.002476968095078	0.0466564566983357	8:11842523-11869448:-	CTSB	31;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030574,biological_process collagen catabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0036021,cellular_component endolysosome lumen;GO:0042470,cellular_component melanosome;GO:0042981,biological_process regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0043394,molecular_function proteoglycan binding;GO:0046697,biological_process decidualization;GO:0046718,biological_process viral entry into host cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050790,biological_process regulation of catalytic activity;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:1904813,cellular_component ficolin-1-rich granule lumen	CTSB; cathepsin B [EC:3.4.22.1]; K01363	cathepsin B [Source:HGNC Symbol%3BAcc:HGNC:2527]
ENSG00000122378	20.46	24.76	22.39	16.24	19.65	17.30	0.350602600007752	3.79742400980134	0.00248420074392327	0.046721793688363	10:80407828-80437115:+	FAM213A	7;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0016209,molecular_function antioxidant activity;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	NA	family with sequence similarity 213 member A [Source:HGNC Symbol%3BAcc:HGNC:28651]
ENSG00000024422	94.92	87.01	94.80	80.69	75.80	85.52	0.206063919303155	7.2005554286443	0.00249597428159003	0.0468722068946702	19:47713342-47743134:+	EHD2	32;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006897,biological_process endocytosis;GO:0007596,biological_process blood coagulation;GO:0010008,cellular_component endosome membrane;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019898,cellular_component extrinsic component of membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0032456,biological_process endocytic recycling;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055038,cellular_component recycling endosome membrane;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane;GO:0097320,biological_process membrane tubulation;GO:1901741,biological_process positive regulation of myoblast fusion;GO:2001137,biological_process positive regulation of endocytic recycling	EHD2; EH domain-containing protein 2; K12469	EH domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:3243]
ENSG00000137331	112.88	109.08	135.40	149.36	128.93	158.94	-0.277719987714177	6.26926712635656	0.00251165304811987	0.0470953916711661	6:30743198-30744554:-	IER3	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010941,biological_process regulation of cell death;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:2001020,biological_process regulation of response to DNA damage stimulus	NA	immediate early response 3 [Source:HGNC Symbol%3BAcc:HGNC:5392]
ENSG00000198246	10.01	10.13	9.50	12.98	12.56	11.35	-0.304212112522483	3.99799347364662	0.00251616299506846	0.0471087952606105	10:71319257-71363385:+	SLC29A3	13;GO:0005337,molecular_function nucleoside transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0015858,biological_process nucleoside transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:1901642,biological_process nucleoside transmembrane transport	SLC29A1_2_3, ENT1_2_3; solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3; K15014	solute carrier family 29 member 3 [Source:HGNC Symbol%3BAcc:HGNC:23096]
ENSG00000197858	65.30	65.31	62.69	52.47	60.87	55.03	0.210746308592725	6.8379704412414	0.0025796669046862	0.0482250079636594	8:144082589-144086216:+	GPAA1	13;GO:0003923,molecular_function GPI-anchor transamidase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006461,biological_process protein complex assembly;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0006621,biological_process protein retention in ER lumen;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016255,biological_process attachment of GPI anchor to protein;GO:0034235,molecular_function GPI anchor binding;GO:0042765,cellular_component GPI-anchor transamidase complex	GAA1; GPI-anchor transamidase subunit GAA1; K05289	glycosylphosphatidylinositol anchor attachment 1 [Source:HGNC Symbol%3BAcc:HGNC:4446]
ENSG00000139974	18.69	19.48	18.39	14.56	17.50	15.80	0.25110920690747	4.99397133790304	0.00258651887685776	0.048240732984093	14:60981113-61083733:+	SLC38A6	10;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 38 member 6 [Source:HGNC Symbol%3BAcc:HGNC:19863]
ENSG00000135069	227.40	172.19	223.99	265.36	235.79	263.79	-0.282009924817916	8.00756766249918	0.00259055939406114	0.048240732984093	9:78297142-78330093:+	PSAT1	10;GO:0003824,molecular_function catalytic activity;GO:0004648,molecular_function O-phospho-L-serine:2-oxoglutarate aminotransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006564,biological_process L-serine biosynthetic process;GO:0008483,molecular_function transaminase activity;GO:0008615,biological_process pyridoxine biosynthetic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0070062,cellular_component extracellular exosome	serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52]; K00831	phosphoserine aminotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:19129]
ENSG00000149596	3.13	2.96	3.13	2.32	2.10	2.35	0.459554644292911	2.51814528229941	0.00259355050970762	0.048240732984093	20:44111694-44187578:-	JPH2	27;GO:0001786,molecular_function phosphatidylserine binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0014701,cellular_component junctional sarcoplasmic reticulum membrane;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0030018,cellular_component Z disc;GO:0030314,cellular_component junctional membrane complex;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0055024,biological_process regulation of cardiac muscle tissue development;GO:0055074,biological_process calcium ion homeostasis;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0060316,biological_process positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0060402,biological_process calcium ion transport into cytosol;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0070300,molecular_function phosphatidic acid binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	junctophilin 2 [Source:HGNC Symbol%3BAcc:HGNC:14202]
ENSG00000073150	1.20	0.79	0.89	0.62	0.44	0.48	0.933388419441594	0.741555719582761	0.00259605330164941	0.048240732984093	22:50170730-50180294:+	PANX2	17;GO:0002931,biological_process response to ischemia;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005921,cellular_component gap junction;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0007267,biological_process cell-cell signaling;GO:0012505,cellular_component endomembrane system;GO:0015267,molecular_function channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022829,molecular_function wide pore channel activity;GO:0030054,cellular_component cell junction;GO:0034214,biological_process protein hexamerization;GO:0055077,molecular_function gap junction hemi-channel activity;GO:0055085,biological_process transmembrane transport	PANX1; pannexin 1; K03443	pannexin 2 [Source:HGNC Symbol%3BAcc:HGNC:8600]
ENSG00000187554	5.54	4.31	5.58	4.04	4.21	3.74	0.386687190278164	3.57892905025117	0.002635018236157	0.0488916014430744	1:223109405-223143282:-	TLR5	20;GO:0001819,biological_process positive regulation of cytokine production;GO:0002376,biological_process immune system process;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005149,molecular_function interleukin-1 receptor binding;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0008584,biological_process male gonad development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0034123,biological_process positive regulation of toll-like receptor signaling pathway;GO:0034146,biological_process toll-like receptor 5 signaling pathway;GO:0042742,biological_process defense response to bacterium;GO:0045087,biological_process innate immune response;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0050707,biological_process regulation of cytokine secretion;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071260,biological_process cellular response to mechanical stimulus	TLR5; toll-like receptor 5; K10168	toll like receptor 5 [Source:HGNC Symbol%3BAcc:HGNC:11851]
ENSG00000126458	108.31	98.49	95.10	85.98	82.57	93.00	0.21925508423328	5.94494631061979	0.00264171809808317	0.0489427563455319	19:49635291-49640201:-	RRAS	19;GO:0000166,molecular_function nucleotide binding;GO:0002521,biological_process leukocyte differentiation;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030336,biological_process negative regulation of cell migration;GO:0032403,molecular_function protein complex binding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0051896,biological_process regulation of protein kinase B signaling;GO:0060325,biological_process face morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade	RRAS; Ras-related protein R-Ras; K07829	related RAS viral (r-ras) oncogene homolog [Source:HGNC Symbol%3BAcc:HGNC:10447]
ENSG00000148690	35.72	29.33	30.76	24.88	27.53	27.53	0.278128541936907	4.8008066020103	0.00265411712258924	0.0490991890353208	10:93667882-93702572:-	FRA10AC1	2;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	FRA10A associated CGG repeat 1 [Source:HGNC Symbol%3BAcc:HGNC:1162]
ENSG00000128641	49.01	47.52	48.11	52.84	55.98	56.67	-0.182228837733679	7.48782486127084	0.00266372817833678	0.0492036575560929	2:191245184-191425389:+	MYO1B	28;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0007015,biological_process actin filament organization;GO:0010008,cellular_component endosome membrane;GO:0016459,cellular_component myosin complex;GO:0030048,biological_process actin filament-based movement;GO:0030175,cellular_component filopodium;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0032588,cellular_component trans-Golgi network membrane;GO:0045177,cellular_component apical part of cell;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0070062,cellular_component extracellular exosome;GO:0071944,cellular_component cell periphery	MYO1; myosin I; K10356	myosin IB [Source:HGNC Symbol%3BAcc:HGNC:7596]
ENSG00000144645	23.54	22.13	24.50	28.55	25.93	27.22	-0.20532491057996	5.95257973894882	0.00268242631277281	0.0494754202384084	3:31657889-32077580:-	OSBPL10	12;GO:0001786,molecular_function phosphatidylserine binding;GO:0005548,molecular_function phospholipid transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0015485,molecular_function cholesterol binding;GO:0015914,biological_process phospholipid transport;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling	NA	oxysterol binding protein like 10 [Source:HGNC Symbol%3BAcc:HGNC:16395]
ENSG00000135549	68.56	79.87	69.03	63.67	57.85	54.66	0.308800305332023	4.17331793261812	0.00268841425616208	0.0495122940085162	6:122471916-122726373:+	PKIB	10;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0051973,biological_process positive regulation of telomerase activity;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:1904355,biological_process positive regulation of telomere capping;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity	NA	cAMP-dependent protein kinase inhibitor beta [Source:HGNC Symbol%3BAcc:HGNC:9018]
ENSG00000084093	8.74	9.10	8.92	10.28	10.73	10.38	-0.21986158987503	5.05095582498586	0.00270050843773297	0.049661349981599	4:56907875-56966678:+	REST	48;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0015271,molecular_function outward rectifier potassium channel activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0032348,biological_process negative regulation of aldosterone biosynthetic process;GO:0035690,biological_process cellular response to drug;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045955,biological_process negative regulation of calcium ion-dependent exocytosis;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046872,molecular_function metal ion binding;GO:0050768,biological_process negative regulation of neurogenesis;GO:0060379,biological_process cardiac muscle cell myoblast differentiation;GO:0070933,biological_process histone H4 deacetylation;GO:0071257,biological_process cellular response to electrical stimulus;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0071805,biological_process potassium ion transmembrane transport;GO:2000065,biological_process negative regulation of cortisol biosynthetic process;GO:2000706,biological_process negative regulation of dense core granule biogenesis;GO:2000740,biological_process negative regulation of mesenchymal stem cell differentiation;GO:2000798,biological_process negative regulation of amniotic stem cell differentiation	REST; RE1-silencing transcription factor; K09222	RE1 silencing transcription factor [Source:HGNC Symbol%3BAcc:HGNC:9966]
ENSG00000166523	10.00	7.77	9.29	12.08	11.49	13.22	-0.417586462464877	2.96515346576229	0.00270817686321471	0.0497286973418405	12:8533304-8540963:-	CLEC4E	13;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002292,biological_process T cell differentiation involved in immune response;GO:0002376,biological_process immune system process;GO:0004872,molecular_function receptor activity;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0038094,biological_process Fc-gamma receptor signaling pathway;GO:0042742,biological_process defense response to bacterium;GO:0045087,biological_process innate immune response;GO:0050715,biological_process positive regulation of cytokine secretion	CLEC4E, MINCLE; C-type lectin domain family 4 member E; K10059	C-type lectin domain family 4 member E [Source:HGNC Symbol%3BAcc:HGNC:14555]
ENSG00000064201	1.68	1.37	1.26	0.86	0.72	0.47	1.09162935294311	0.327161950971662	0.00271225959886051	0.0497301010349417	11:2301996-2318200:+	TSPAN32	18;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0005887,cellular_component integral component of plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030886,biological_process negative regulation of myeloid dendritic cell activation;GO:0042832,biological_process defense response to protozoan;GO:0050688,biological_process regulation of defense response to virus;GO:0070442,cellular_component integrin alphaIIb-beta3 complex;GO:0070527,biological_process platelet aggregation	NA	tetraspanin 32 [Source:HGNC Symbol%3BAcc:HGNC:13410]
ENSG00000163435	111.43	109.56	108.38	123.98	135.81	121.43	-0.19886539470166	7.0451716131062	0.00273619173797494	0.0500949086187064	1:202007944-202017188:+	ELF3	29;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001824,biological_process blastocyst development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007275,biological_process multicellular organism development;GO:0008544,biological_process epidermis development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030154,biological_process cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0030855,biological_process epithelial cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060056,biological_process mammary gland involution	NA	E74 like ETS transcription factor 3 [Source:HGNC Symbol%3BAcc:HGNC:3318]
ENSG00000070614	35.34	34.74	35.02	41.96	38.64	40.53	-0.192767842461368	6.64420574480123	0.00274273140852637	0.0501406847923973	5:150485817-150558211:+	NDST1	35;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000271,biological_process polysaccharide biosynthetic process;GO:0003279,biological_process cardiac septum development;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006477,biological_process protein sulfation;GO:0006954,biological_process inflammatory response;GO:0007224,biological_process smoothened signaling pathway;GO:0007507,biological_process heart development;GO:0007585,biological_process respiratory gaseous exchange;GO:0008146,molecular_function sulfotransferase activity;GO:0008152,biological_process metabolic process;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009887,biological_process organ morphogenesis;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0015014,biological_process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0015016,molecular_function [heparan sulfate]-glucosamine N-sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0019213,molecular_function deacetylase activity;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030210,biological_process heparin biosynthetic process;GO:0030900,biological_process forebrain development;GO:0030901,biological_process midbrain development;GO:0035904,biological_process aorta development;GO:0042328,molecular_function heparan sulfate N-acetylglucosaminyltransferase activity;GO:0048702,biological_process embryonic neurocranium morphogenesis;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0050119,molecular_function N-acetylglucosamine deacetylase activity;GO:0060976,biological_process coronary vasculature development	NDST1; heparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.1.1.- 2.8.2.-]; K02576	N-deacetylase and N-sulfotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:7680]
ENSG00000148082	6.05	6.06	5.69	7.29	7.09	8.22	-0.335546261343664	3.61997602853754	0.00275124064752001	0.0502092676143959	9:89005770-89178767:-	SHC3	19;GO:0000165,biological_process MAPK cascade;GO:0001784,molecular_function phosphotyrosine binding;GO:0004871,molecular_function signal transducer activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0007611,biological_process learning or memory;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	SHC3; SHC-transforming protein 3; K17448	SHC adaptor protein 3 [Source:HGNC Symbol%3BAcc:HGNC:18181]
ENSG00000125148	430.40	400.57	428.46	474.51	465.89	516.88	-0.197771604254205	7.12692381241118	0.00275457272580388	0.0502092676143959	16:56608198-56609497:+	MT2A	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006878,biological_process cellular copper ion homeostasis;GO:0008144,molecular_function drug binding;GO:0008270,molecular_function zinc ion binding;GO:0010038,biological_process response to metal ion;GO:0035690,biological_process cellular response to drug;GO:0036016,biological_process cellular response to interleukin-3;GO:0036018,biological_process cellular response to erythropoietin;GO:0045926,biological_process negative regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0071294,biological_process cellular response to zinc ion	MT1_2; metallothionein 1/2; K14739	metallothionein 2A [Source:HGNC Symbol%3BAcc:HGNC:7406]
ENSG00000111206	35.67	38.61	34.84	42.04	43.03	41.30	-0.202092688551887	6.56402161952708	0.00277625213871818	0.050510770086534	12:2857680-2877155:-	FOXM1	31;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009653,biological_process anatomical structure morphogenesis;GO:0019901,molecular_function protein kinase binding;GO:0030154,biological_process cell differentiation;GO:0032873,biological_process negative regulation of stress-activated MAPK cascade;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046578,biological_process regulation of Ras protein signal transduction;GO:0051726,biological_process regulation of cell cycle;GO:0071156,biological_process regulation of cell cycle arrest;GO:0090344,biological_process negative regulation of cell aging;GO:2000377,biological_process regulation of reactive oxygen species metabolic process;GO:2000781,biological_process positive regulation of double-strand break repair	FOXM; forkhead box protein M; K09406	forkhead box M1 [Source:HGNC Symbol%3BAcc:HGNC:3818]
ENSG00000162913	3.13	0.45	2.33	0.71	0.72	0.78	1.46466859361031	0.0532911277013409	0.00277925207194898	0.050510770086534	1:228203505-228213664:-	OBSCN-AS1	NA	NA	OBSCN antisense RNA 1 [Source:HGNC Symbol%3BAcc:HGNC:32047]
ENSG00000145050	91.26	93.17	80.72	78.09	78.83	67.55	0.250782573383355	5.51163533542048	0.0028063739967512	0.0508551426521774	3:51385046-51389397:+	MANF	3;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	mesencephalic astrocyte derived neurotrophic factor [Source:HGNC Symbol%3BAcc:HGNC:15461]
ENSG00000008517	92.93	99.01	89.81	106.98	111.25	107.26	-0.198151821239878	6.70096750805219	0.00280952958738996	0.0508551426521774	16:3065296-3082192:+	IL32	9;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0006952,biological_process defense response;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane	NA	interleukin 32 [Source:HGNC Symbol%3BAcc:HGNC:16830]
ENSG00000175567	44.32	55.94	41.50	35.59	41.90	37.18	0.312630313923809	5.37561038003338	0.00281581384127414	0.0508551426521774	11:73974666-73983307:-	UCP2	29;GO:0000303,biological_process response to superoxide;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0009409,biological_process response to cold;GO:0009749,biological_process response to glucose;GO:0010942,biological_process positive regulation of cell death;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017077,molecular_function oxidative phosphorylation uncoupler activity;GO:0031966,cellular_component mitochondrial membrane;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032870,biological_process cellular response to hormone stimulus;GO:0034198,biological_process cellular response to amino acid starvation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070542,biological_process response to fatty acid;GO:0071333,biological_process cellular response to glucose stimulus;GO:0097421,biological_process liver regeneration;GO:1990542,biological_process mitochondrial transmembrane transport;GO:1990845,biological_process adaptive thermogenesis	NA	uncoupling protein 2 [Source:HGNC Symbol%3BAcc:HGNC:12518]
ENSG00000067369	16.61	18.66	17.01	13.60	16.09	15.26	0.228057609322105	6.63104897529593	0.00281691923552129	0.0508551426521774	15:43403060-43510728:-	TP53BP1	37;GO:0000077,biological_process DNA damage checkpoint;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016604,cellular_component nuclear body;GO:0016925,biological_process protein sumoylation;GO:0035064,molecular_function methylated histone binding;GO:0035861,cellular_component site of double-strand break;GO:0042162,molecular_function telomeric DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045830,biological_process positive regulation of isotype switching;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051260,biological_process protein homooligomerization;GO:0061649,molecular_function ubiquitinated histone binding;GO:0071481,biological_process cellular response to X-ray;GO:1990391,cellular_component DNA repair complex;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination	NA	tumor protein p53 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11999]
ENSG00000137825	8.25	5.55	8.75	11.76	8.10	13.49	-0.544247100331852	3.75313770255182	0.00281868509987094	0.0508551426521774	15:41493392-41503551:+	ITPKA	19;GO:0000166,molecular_function nucleotide binding;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006020,biological_process inositol metabolic process;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0008440,molecular_function inositol-1,4,5-trisphosphate 3-kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0043197,cellular_component dendritic spine;GO:0043647,biological_process inositol phosphate metabolic process;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048365,molecular_function Rac GTPase binding;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0097062,biological_process dendritic spine maintenance	ITPK; 1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127]; K00911	inositol-trisphosphate 3-kinase A [Source:HGNC Symbol%3BAcc:HGNC:6178]
ENSG00000196743	43.62	42.96	40.72	34.92	38.88	34.37	0.247041407383356	4.81462051582501	0.00283261439971924	0.0510322823566254	5:151212149-151270440:+	GM2A	31;GO:0001573,biological_process ganglioside metabolic process;GO:0004563,molecular_function beta-N-acetylhexosaminidase activity;GO:0005319,molecular_function lipid transporter activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005889,cellular_component hydrogen:potassium-exchanging ATPase complex;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006689,biological_process ganglioside catabolic process;GO:0006869,biological_process lipid transport;GO:0007611,biological_process learning or memory;GO:0008047,molecular_function enzyme activator activity;GO:0009313,biological_process oligosaccharide catabolic process;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016004,molecular_function phospholipase activator activity;GO:0016787,molecular_function hydrolase activity;GO:0019915,biological_process lipid storage;GO:0030290,molecular_function sphingolipid activator protein activity;GO:0032428,molecular_function beta-N-acetylgalactosaminidase activity;GO:0035578,cellular_component azurophil granule lumen;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045179,cellular_component apical cortex;GO:0050877,biological_process neurological system process;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051345,biological_process positive regulation of hydrolase activity;GO:0070062,cellular_component extracellular exosome	GM2A; ganglioside GM2 activator; K12383	GM2 ganglioside activator [Source:HGNC Symbol%3BAcc:HGNC:4367]
ENSG00000144959	24.28	23.18	25.41	30.42	28.84	27.10	-0.229581598839802	5.16567820577328	0.00284444000533904	0.0511710634583674	3:172630248-172711218:-	NCEH1	18;GO:0004771,molecular_function sterol esterase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0009056,biological_process catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0017171,molecular_function serine hydrolase activity;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0042301,molecular_function phosphate ion binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0060395,biological_process SMAD protein signal transduction	NCEH1, AADACL1; neutral cholesterol ester hydrolase 1 [EC:3.1.1.-]; K14349	neutral cholesterol ester hydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:29260]
ENSG00000137575	357.48	355.30	345.39	314.98	320.96	310.81	0.172210381196061	8.32265043611329	0.00285425453440019	0.0512733162597822	8:58552923-58582860:+	SDCBP	63;GO:0002091,biological_process negative regulation of receptor internalization;GO:0005109,molecular_function frizzled binding;GO:0005137,molecular_function interleukin-5 receptor binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005895,cellular_component interleukin-5 receptor complex;GO:0005912,cellular_component adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006612,biological_process protein targeting to membrane;GO:0006930,biological_process substrate-dependent cell migration, cell extension;GO:0007265,biological_process Ras protein signal transduction;GO:0007268,biological_process chemical synaptic transmission;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019838,molecular_function growth factor binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0031965,cellular_component nuclear membrane;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035556,biological_process intracellular signal transduction;GO:0035578,cellular_component azurophil granule lumen;GO:0042043,molecular_function neurexin family protein binding;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042470,cellular_component melanosome;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0045545,molecular_function syndecan binding;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046875,molecular_function ephrin receptor binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050839,molecular_function cell adhesion molecule binding;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903553,biological_process positive regulation of extracellular exosome assembly;GO:1903561,cellular_component extracellular vesicle	NA	syndecan binding protein [Source:HGNC Symbol%3BAcc:HGNC:10662]
ENSG00000134352	23.32	22.07	22.53	19.26	21.28	18.74	0.210000884493898	5.88518206971352	0.00285866656781001	0.0512783643153549	5:55935094-55994993:-	IL6ST	49;GO:0002675,biological_process positive regulation of acute inflammatory response;GO:0002821,biological_process positive regulation of adaptive immune response;GO:0004896,molecular_function cytokine receptor activity;GO:0004897,molecular_function ciliary neurotrophic factor receptor activity;GO:0004915,molecular_function interleukin-6 receptor activity;GO:0004921,molecular_function interleukin-11 receptor activity;GO:0004923,molecular_function leukemia inhibitory factor receptor activity;GO:0004924,molecular_function oncostatin-M receptor activity;GO:0005127,molecular_function ciliary neurotrophic factor receptor binding;GO:0005138,molecular_function interleukin-6 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005896,cellular_component interleukin-6 receptor complex;GO:0005900,cellular_component oncostatin-M receptor complex;GO:0005977,biological_process glycogen metabolic process;GO:0007165,biological_process signal transduction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019838,molecular_function growth factor binding;GO:0019970,molecular_function interleukin-11 binding;GO:0019981,molecular_function interleukin-6 binding;GO:0030425,cellular_component dendrite;GO:0034097,biological_process response to cytokine;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0038154,biological_process interleukin-11-mediated signaling pathway;GO:0038165,biological_process oncostatin-M-mediated signaling pathway;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044297,cellular_component cell body;GO:0045509,molecular_function interleukin-27 receptor activity;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0048861,biological_process leukemia inhibitory factor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070102,biological_process interleukin-6-mediated signaling pathway;GO:0070106,biological_process interleukin-27-mediated signaling pathway;GO:0070110,cellular_component ciliary neurotrophic factor receptor complex;GO:0070120,biological_process ciliary neurotrophic factor-mediated signaling pathway	IL6ST, GP130, CD130; interleukin 6 signal transducer; K05060	interleukin 6 signal transducer [Source:HGNC Symbol%3BAcc:HGNC:6021]
ENSG00000137203	21.51	22.04	24.79	18.40	20.85	18.69	0.251730946904301	5.12214452326343	0.00286363399123828	0.0512933459354123	6:10393185-10419659:-	TFAP2A	54;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001822,biological_process kidney development;GO:0003404,biological_process optic vesicle morphogenesis;GO:0003409,biological_process optic cup structural organization;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007605,biological_process sensory perception of sound;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010842,biological_process retina layer formation;GO:0010944,biological_process negative regulation of transcription by competitive promoter binding;GO:0021559,biological_process trigeminal nerve development;GO:0021623,biological_process oculomotor nerve formation;GO:0030501,biological_process positive regulation of bone mineralization;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0042472,biological_process inner ear morphogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045595,biological_process regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0060021,biological_process palate development;GO:0060349,biological_process bone morphogenesis;GO:0061029,biological_process eyelid development in camera-type eye;GO:0070172,biological_process positive regulation of tooth mineralization;GO:0071281,biological_process cellular response to iron ion;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	NA	transcription factor AP-2 alpha [Source:HGNC Symbol%3BAcc:HGNC:11742]
ENSG00000179477	0.27	0.14	0.28	0.50	0.61	0.53	-1.1899991494305	-0.0182842572463168	0.00289606095019609	0.051747910755616	17:8072635-8087703:-	ALOX12B	25;GO:0003824,molecular_function catalytic activity;GO:0004052,molecular_function arachidonate 12-lipoxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006497,biological_process protein lipidation;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0010628,biological_process positive regulation of gene expression;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0019369,biological_process arachidonic acid metabolic process;GO:0019372,biological_process lipoxygenase pathway;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043651,biological_process linoleic acid metabolic process;GO:0046513,biological_process ceramide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0051122,biological_process hepoxilin biosynthetic process;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0061436,biological_process establishment of skin barrier;GO:0070257,biological_process positive regulation of mucus secretion;GO:1990136,molecular_function linoleate 9S-lipoxygenase activity	ALOX12B; arachidonate 12-lipoxygenase (R-type) [EC:1.13.11.-]; K08021	arachidonate 12-lipoxygenase%2C 12R type [Source:HGNC Symbol%3BAcc:HGNC:430]
ENSG00000094880	23.35	24.40	24.69	27.84	26.66	30.05	-0.212807846103989	5.62058047335316	0.00289734938976501	0.051747910755616	5:138187647-138213343:-	CDC23	22;GO:0000278,biological_process mitotic cell cycle;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007091,biological_process metaphase/anaphase transition of mitotic cell cycle;GO:0007096,biological_process regulation of exit from mitosis;GO:0016567,biological_process protein ubiquitination;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC8, CDC23; anaphase-promoting complex subunit 8; K03355	cell division cycle 23 [Source:HGNC Symbol%3BAcc:HGNC:1724]
ENSG00000079134	26.90	25.28	26.74	28.70	30.89	32.01	-0.201451324401766	5.86744399409775	0.00294426841929903	0.0525103504148835	18:214519-268050:-	THOC1	34;GO:0000018,biological_process regulation of DNA recombination;GO:0000346,cellular_component transcription export complex;GO:0000347,cellular_component THO complex;GO:0000445,cellular_component THO complex part of transcription export complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008380,biological_process RNA splicing;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0031297,biological_process replication fork processing;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0045171,cellular_component intercellular bridge;GO:0046784,biological_process viral mRNA export from host cell nucleus;GO:0048297,biological_process negative regulation of isotype switching to IgA isotypes;GO:0051028,biological_process mRNA transport;GO:2000002,biological_process negative regulation of DNA damage checkpoint	THOC1; THO complex subunit 1; K12878	THO complex 1 [Source:HGNC Symbol%3BAcc:HGNC:19070]
ENSG00000185862	1.26	1.00	1.86	0.61	0.79	0.73	0.975152593338088	0.639622455730898	0.00295156440522138	0.0525286583857889	17:31303765-31314112:-	EVI2B	3;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ecotropic viral integration site 2B [Source:HGNC Symbol%3BAcc:HGNC:3500]
ENSG00000157693	5.83	4.83	5.58	8.73	6.04	8.54	-0.502404174031075	2.80763286271237	0.00295375844302591	0.0525286583857889	9:114611205-114646422:+	TMEM268	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 268 [Source:HGNC Symbol%3BAcc:HGNC:24513]
ENSG00000133639	198.80	163.75	219.51	171.93	127.88	165.72	0.335449258282764	6.49009762118053	0.0029677598332366	0.0527021499427266	12:92140277-92145897:-	BTG1	15;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006479,biological_process protein methylation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016477,biological_process cell migration;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0030308,biological_process negative regulation of cell growth;GO:0045603,biological_process positive regulation of endothelial cell differentiation;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:2000271,biological_process positive regulation of fibroblast apoptotic process	TOB; protein Tob/BTG; K14443	BTG anti-proliferation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:1130]
ENSG00000168056	65.37	56.14	66.53	54.48	51.10	56.97	0.222943412318866	7.85894829292975	0.00297349387763362	0.0527285421472373	11:65538804-65558930:-	LTBP3	9;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0019838,molecular_function growth factor binding;GO:0031012,cellular_component extracellular matrix;GO:0036363,biological_process transforming growth factor beta activation;GO:0050431,molecular_function transforming growth factor beta binding;GO:0070062,cellular_component extracellular exosome;GO:1902462,biological_process positive regulation of mesenchymal stem cell proliferation;GO:2000741,biological_process positive regulation of mesenchymal stem cell differentiation	NA	latent transforming growth factor beta binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:6716]
ENSG00000142765	4.48	3.17	5.24	7.99	4.63	7.30	-0.605344616503664	3.2475141327222	0.00298493305969415	0.0528558831240849	1:27342019-27353937:+	SYTL1	22;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0019905,molecular_function syntaxin binding;GO:0030276,molecular_function clathrin binding;GO:0031528,cellular_component microvillus membrane;GO:0042043,molecular_function neurexin family protein binding;GO:0042470,cellular_component melanosome;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070382,cellular_component exocytic vesicle;GO:0098793,cellular_component presynapse	NA	synaptotagmin like 1 [Source:HGNC Symbol%3BAcc:HGNC:15584]
ENSG00000166326	65.01	63.25	66.26	75.16	71.73	76.72	-0.188506045662264	6.17335011993019	0.00300492639777367	0.0531341187686105	11:35662804-35818007:+	TRIM44	5;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0008270,molecular_function zinc ion binding;GO:0010468,biological_process regulation of gene expression;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 44 [Source:HGNC Symbol%3BAcc:HGNC:19016]
ENSG00000170275	225.67	229.34	226.55	198.23	207.23	204.35	0.172145450961559	8.01811167314122	0.00302606194106641	0.0534317309736236	3:33113978-33147773:+	CRTAP	12;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007283,biological_process spermatogenesis;GO:0018400,biological_process peptidyl-proline hydroxylation to 3-hydroxy-L-proline;GO:0032403,molecular_function protein complex binding;GO:0032991,cellular_component macromolecular complex;GO:0050821,biological_process protein stabilization;GO:0061077,biological_process chaperone-mediated protein folding;GO:1901874,biological_process negative regulation of post-translational protein modification	NA	cartilage associated protein [Source:HGNC Symbol%3BAcc:HGNC:2379]
ENSG00000154240	4.45	4.29	3.96	5.38	5.40	5.03	-0.303097523724331	3.87464708013121	0.00303890999961231	0.0535746064672033	17:65635537-66192084:-	CEP112	7;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0060077,cellular_component inhibitory synapse;GO:0097120,biological_process receptor localization to synapse	NA	centrosomal protein 112 [Source:HGNC Symbol%3BAcc:HGNC:28514]
ENSG00000117472	7.52	9.12	7.23	10.36	10.28	11.87	-0.449695441158068	2.79746458986873	0.00304278559247388	0.0535746064672033	1:46175072-46185958:+	TSPAN1	19;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0030054,cellular_component cell junction;GO:0031982,cellular_component vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045807,biological_process positive regulation of endocytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome	NA	tetraspanin 1 [Source:HGNC Symbol%3BAcc:HGNC:20657]
ENSG00000183597	10.42	10.14	9.71	8.01	8.75	6.68	0.383732327585913	3.29585427445597	0.00304803617339616	0.0535910382724738	22:20017013-20065926:+	TANGO2	1;GO:0005794,cellular_component Golgi apparatus	NA	transport and golgi organization 2 homolog [Source:HGNC Symbol%3BAcc:HGNC:25439]
ENSG00000146676	16.90	16.03	15.73	18.96	20.18	20.36	-0.277030284540953	4.09368995928979	0.00307512939307288	0.0539909210130321	7:44876292-44885361:-	PURB	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005662,cellular_component DNA replication factor A complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0030154,biological_process cell differentiation;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046332,molecular_function SMAD binding	NA	purine rich element binding protein B [Source:HGNC Symbol%3BAcc:HGNC:9702]
ENSG00000172915	3.57	3.34	3.67	2.74	3.10	3.17	0.248381570517113	4.87230012096988	0.00308497102204299	0.0540872108709317	13:34942286-35673022:+	NBEA	8;GO:0005737,cellular_component cytoplasm;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008104,biological_process protein localization;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding	NA	neurobeachin [Source:HGNC Symbol%3BAcc:HGNC:7648]
ENSG00000132570	11.59	8.82	9.81	14.21	13.42	15.87	-0.500150837519417	2.32030089661752	0.00310319375306568	0.0543299634087508	5:134904905-135007959:+	PCBD2	12;GO:0004505,molecular_function phenylalanine 4-monooxygenase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006729,biological_process tetrahydrobiopterin biosynthetic process;GO:0008124,molecular_function 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;GO:0016829,molecular_function lyase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051289,biological_process protein homotetramerization;GO:0051291,biological_process protein heterooligomerization;GO:0055114,biological_process oxidation-reduction process	PCBD, phhB; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]; K01724	pterin-4 alpha-carbinolamine dehydratase 2 [Source:HGNC Symbol%3BAcc:HGNC:24474]
ENSG00000011201	0.35	0.52	0.61	0.81	0.82	1.24	-0.957236126566087	0.718607407323307	0.00311427165067324	0.054415270116786	X:8528873-8732186:-	ANOS1	17;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0007411,biological_process axon guidance;GO:0008201,molecular_function heparin binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0030414,molecular_function peptidase inhibitor activity	NA	anosmin 1 [Source:HGNC Symbol%3BAcc:HGNC:6211]
ENSG00000119004	9.52	9.01	9.34	11.58	11.62	11.17	-0.286350633488069	3.88999722217514	0.0031205148481713	0.054415270116786	2:203238939-203305611:+	CYP20A1	9;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037,molecular_function heme binding;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome P450 family 20 subfamily A member 1 [Source:HGNC Symbol%3BAcc:HGNC:20576]
ENSG00000108684	1.04	0.89	0.79	0.40	0.68	0.41	0.890405726689303	0.774812601519528	0.00312121745936934	0.054415270116786	17:33013086-34174964:-	ASIC2	41;GO:0003026,biological_process regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback;GO:0005216,molecular_function ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007417,biological_process central nervous system development;GO:0007422,biological_process peripheral nervous system development;GO:0007602,biological_process phototransduction;GO:0007605,biological_process sensory perception of sound;GO:0009612,biological_process response to mechanical stimulus;GO:0010447,biological_process response to acidic pH;GO:0010468,biological_process regulation of gene expression;GO:0015280,molecular_function ligand-gated sodium channel activity;GO:0015672,biological_process monovalent inorganic cation transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019229,biological_process regulation of vasoconstriction;GO:0022839,molecular_function ion gated channel activity;GO:0030193,biological_process regulation of blood coagulation;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035418,biological_process protein localization to synapse;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0044736,molecular_function acid-sensing ion channel activity;GO:0045202,cellular_component synapse;GO:0050915,biological_process sensory perception of sour taste;GO:0050974,biological_process detection of mechanical stimulus involved in sensory perception;GO:0051965,biological_process positive regulation of synapse assembly;GO:0098655,biological_process cation transmembrane transport	ASIC2, ACCN1, BNAC1; acid-sensing ion channel 2; K04828	acid sensing ion channel subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:99]
ENSG00000092199	649.83	673.69	649.03	774.74	733.14	735.64	-0.174117477273916	9.4432760256983	0.00313911118981538	0.0546504729301239	14:21209135-21269494:-	HNRNPC	31;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008266,molecular_function poly(U) RNA binding;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031492,molecular_function nucleosomal DNA binding;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0042802,molecular_function identical protein binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0070034,molecular_function telomerase RNA binding;GO:0070062,cellular_component extracellular exosome;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1990247,molecular_function N6-methyladenosine-containing RNA binding	HNRNPC; heterogeneous nuclear ribonucleoprotein C1/C2; K12884	heterogeneous nuclear ribonucleoprotein C (C1/C2) [Source:HGNC Symbol%3BAcc:HGNC:5035]
ENSG00000189159	139.74	140.06	129.51	153.64	154.70	164.11	-0.196327996264238	6.5878682923787	0.00314739504122918	0.0547179476845628	17:75135247-75168281:-	JPT1	4;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0031965,cellular_component nuclear membrane	NA	Jupiter microtubule associated homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:14569]
ENSG00000169679	36.41	35.26	31.54	40.67	42.50	37.87	-0.218374223645443	6.92944245295929	0.0031587811063742	0.05483909073206	2:110637697-110678114:-	BUB1	31;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000942,cellular_component condensed nuclear chromosome outer kinetochore;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007063,biological_process regulation of sister chromatid cohesion;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0051301,biological_process cell division;GO:0051754,biological_process meiotic sister chromatid cohesion, centromeric;GO:0051983,biological_process regulation of chromosome segregation;GO:0071173,biological_process spindle assembly checkpoint	BUB1; checkpoint serine/threonine-protein kinase [EC:2.7.11.1]; K02178	BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:1148]
ENSG00000266338	24.49	23.20	25.27	22.24	20.04	21.27	0.213317591570241	5.52076797801886	0.00316503095224965	0.0548708508523392	1:144421385-144461674:-	NBPF15	1;GO:0005737,cellular_component cytoplasm	NA	NBPF member 15 [Source:HGNC Symbol%3BAcc:HGNC:28791]
ENSG00000078808	240.29	257.73	231.96	202.86	228.42	207.44	0.203997649343493	8.19120728821547	0.00320259039775177	0.0554433847261694	1:1216907-1232031:-	SDF4	19;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0009650,biological_process UV protection;GO:0016020,cellular_component membrane;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0021549,biological_process cerebellum development;GO:0032059,cellular_component bleb;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0045444,biological_process fat cell differentiation;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070625,biological_process zymogen granule exocytosis	NA	stromal cell derived factor 4 [Source:HGNC Symbol%3BAcc:HGNC:24188]
ENSG00000221867	3.90	4.16	3.75	2.70	2.58	2.46	0.613930553960296	1.67599647705723	0.00320698865974298	0.0554433847261694	X:152698751-152702347:+	MAGEA3	6;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0010955,biological_process negative regulation of protein processing;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0089720,molecular_function caspase binding;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	NA	MAGE family member A3 [Source:HGNC Symbol%3BAcc:HGNC:6801]
ENSG00000096060	16.05	15.68	16.62	20.16	18.19	19.43	-0.243672328265725	4.66897829641109	0.00321642695499778	0.0555292180700798	6:35573584-35728583:-	FKBP5	14;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005528,molecular_function FK506 binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0031072,molecular_function heat shock protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome	FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]; K09571	FK506 binding protein 5 [Source:HGNC Symbol%3BAcc:HGNC:3721]
ENSG00000128590	20.80	20.86	25.30	18.13	17.23	18.18	0.337406943304517	3.76413514623812	0.00324487428087708	0.0558636143078813	7:108569567-108574850:+	DNAJB9	10;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0051787,molecular_function misfolded protein binding;GO:0070062,cellular_component extracellular exosome	NA	DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol%3BAcc:HGNC:6968]
ENSG00000154265	1.56	1.53	1.43	1.89	1.92	2.07	-0.369451940609874	3.1426779530029	0.00324651667473594	0.0558636143078813	17:69244310-69327244:-	ABCA5	23;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005319,molecular_function lipid transporter activity;GO:0005524,molecular_function ATP binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0031902,cellular_component late endosome membrane;GO:0033344,biological_process cholesterol efflux;GO:0034375,biological_process high-density lipoprotein particle remodeling;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043691,biological_process reverse cholesterol transport;GO:0055085,biological_process transmembrane transport	ABCA5; ATP-binding cassette, subfamily A (ABC1), member 5; K05648	ATP binding cassette subfamily A member 5 [Source:HGNC Symbol%3BAcc:HGNC:35]
ENSG00000148634	27.41	29.73	27.53	23.88	25.21	25.35	0.195659732006302	6.53158062252434	0.00324929747283415	0.0558636143078813	10:67921898-68075348:-	HERC4	9;GO:0001650,cellular_component fibrillar center;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007283,biological_process spermatogenesis;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0061630,molecular_function ubiquitin protein ligase activity	HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]; K10615	HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:HGNC Symbol%3BAcc:HGNC:24521]
ENSG00000011028	55.54	45.92	60.41	47.57	38.13	47.07	0.298313448951895	7.77044222046577	0.00328013843072612	0.0563158483272522	17:62627400-62693597:+	MRC2	12;GO:0001649,biological_process osteoblast differentiation;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0030574,biological_process collagen catabolic process	MRC, CD206, CD280; mannose receptor, C type; K06560	mannose receptor C type 2 [Source:HGNC Symbol%3BAcc:HGNC:16875]
ENSG00000120833	2.99	2.49	3.36	5.94	3.79	4.43	-0.652224030201086	1.89506924595552	0.00332338385758098	0.0569795080444099	12:93569813-93583487:+	SOCS2	30;GO:0001558,biological_process regulation of cell growth;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005131,molecular_function growth hormone receptor binding;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007259,biological_process JAK-STAT cascade;GO:0007595,biological_process lactation;GO:0008269,molecular_function JAK pathway signal transduction adaptor activity;GO:0009966,biological_process regulation of signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0009968,biological_process negative regulation of signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032355,biological_process response to estradiol;GO:0032870,biological_process cellular response to hormone stimulus;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0040014,biological_process regulation of multicellular organism growth;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0060396,biological_process growth hormone receptor signaling pathway;GO:0060749,biological_process mammary gland alveolus development	SOCS2, CIS2; suppressor of cytokine signaling 2; K04695	suppressor of cytokine signaling 2 [Source:HGNC Symbol%3BAcc:HGNC:19382]
ENSG00000109670	4.92	4.43	4.00	3.38	3.28	3.74	0.37066556606195	3.38980375040897	0.00333234910213012	0.0570544129720567	4:152321258-152536101:-	FBXW7	41;GO:0000209,biological_process protein polyubiquitination;GO:0001944,biological_process vasculature development;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0010868,biological_process negative regulation of triglyceride biosynthetic process;GO:0010883,biological_process regulation of lipid storage;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030332,molecular_function cyclin binding;GO:0030674,molecular_function protein binding, bridging;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032876,biological_process negative regulation of DNA endoreduplication;GO:0032880,biological_process regulation of protein localization;GO:0042802,molecular_function identical protein binding;GO:0043687,biological_process post-translational protein modification;GO:0045741,biological_process positive regulation of epidermal growth factor-activated receptor activity;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0050816,molecular_function phosphothreonine binding;GO:0050821,biological_process protein stabilization;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0055088,biological_process lipid homeostasis;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0097027,molecular_function ubiquitin-protein transferase activator activity;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902806,biological_process regulation of cell cycle G1/S phase transition;GO:1903146,biological_process regulation of mitophagy;GO:1903378,biological_process positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1990452,cellular_component Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000346,biological_process negative regulation of hepatocyte proliferation;GO:2000639,biological_process negative regulation of SREBP signaling pathway	FBXW7, SEL10; F-box and WD-40 domain protein 7; K10260	F-box and WD repeat domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:16712]
ENSG00000154229	38.11	33.81	37.38	42.56	41.00	42.87	-0.195325139045269	6.35999265410806	0.00333883229216629	0.0570866738879617	17:66302635-66810743:+	PRKCA	58;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002159,biological_process desmosome assembly;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0004698,molecular_function calcium-dependent protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007155,biological_process cell adhesion;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007194,biological_process negative regulation of adenylate cyclase activity;GO:0007411,biological_process axon guidance;GO:0008270,molecular_function zinc ion binding;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030168,biological_process platelet activation;GO:0030335,biological_process positive regulation of cell migration;GO:0031666,biological_process positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0031966,cellular_component mitochondrial membrane;GO:0034351,biological_process negative regulation of glial cell apoptotic process;GO:0035403,molecular_function histone kinase activity (H3-T6 specific);GO:0035408,biological_process histone H3-T6 phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0038128,biological_process ERBB2 signaling pathway;GO:0043488,biological_process regulation of mRNA stability;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050796,biological_process regulation of insulin secretion;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070555,biological_process response to interleukin-1;GO:0090330,biological_process regulation of platelet aggregation;GO:0097190,biological_process apoptotic signaling pathway;GO:2000707,biological_process positive regulation of dense core granule biogenesis	PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]; K02677	protein kinase C alpha [Source:HGNC Symbol%3BAcc:HGNC:9393]
ENSG00000126822	10.24	10.76	10.22	11.68	12.39	12.14	-0.204904454410748	5.39336240546349	0.00335937833228813	0.0573589590628509	14:64704101-64750247:+	PLEKHG3	3;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	pleckstrin homology and RhoGEF domain containing G3 [Source:HGNC Symbol%3BAcc:HGNC:20364]
ENSG00000258989	34.66	34.79	30.70	39.51	42.46	41.15	-0.289287496717005	4.02931538213979	0.00337355068064832	0.0575218195039665	14:61529127-61657964:+	AL355916.3	8;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	NA
ENSG00000185046	1.89	1.71	1.93	1.21	1.52	1.41	0.431652018585499	2.75026158351156	0.00338429885020614	0.0576259281585855	12:98726456-99984654:-	ANKS1B	15;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046875,molecular_function ephrin receptor binding;GO:1900383,biological_process regulation of synaptic plasticity by receptor localization to synapse	NA	ankyrin repeat and sterile alpha motif domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:24600]
ENSG00000183549	12.23	12.30	12.07	14.41	16.63	13.66	-0.275739763554091	4.58357920422866	0.0034475739308151	0.0586229249359012	16:20409533-20441336:+	ACSM5	17;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003996,molecular_function acyl-CoA ligase activity;GO:0004321,molecular_function fatty-acyl-CoA synthase activity;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008152,biological_process metabolic process;GO:0015645,molecular_function fatty acid ligase activity;GO:0016874,molecular_function ligase activity;GO:0046872,molecular_function metal ion binding;GO:0047760,molecular_function butyrate-CoA ligase activity	ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]; K01896	acyl-CoA synthetase medium chain family member 5 [Source:HGNC Symbol%3BAcc:HGNC:26060]
ENSG00000106479	5.16	5.50	5.56	4.25	4.37	4.83	0.278148173763675	4.12658428329927	0.00345392144123604	0.0586505155267619	7:149838366-149867479:+	ZNF862	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity	NA	zinc finger protein 862 [Source:HGNC Symbol%3BAcc:HGNC:34519]
ENSG00000175063	115.28	125.43	117.78	133.96	150.03	133.48	-0.209464958674758	6.47845042283548	0.00347876335152821	0.0589354438434943	20:45812575-45816957:+	UBE2C	32;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0010458,biological_process exit from mitosis;GO:0010994,biological_process free ubiquitin chain polymerization;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031536,biological_process positive regulation of exit from mitosis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	UBE2C, UBC11; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]; K06688	ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol%3BAcc:HGNC:15937]
ENSG00000106692	13.15	12.36	12.77	14.12	17.33	15.35	-0.275009379492908	4.56500663605145	0.0034801965952857	0.0589354438434943	9:105558129-105641118:+	FKTN	16;GO:0000139,cellular_component Golgi membrane;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006486,biological_process protein glycosylation;GO:0007399,biological_process nervous system development;GO:0007517,biological_process muscle organ development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0035269,biological_process protein O-linked mannosylation;GO:0046329,biological_process negative regulation of JNK cascade;GO:0060049,biological_process regulation of protein glycosylation	NA	fukutin [Source:HGNC Symbol%3BAcc:HGNC:3622]
ENSG00000108784	31.66	35.23	33.73	28.29	30.73	29.20	0.199413760430004	6.17989757207803	0.00350472835263212	0.0592700177673331	17:42536171-42544449:+	NAGLU	15;GO:0004561,molecular_function alpha-N-acetylglucosaminidase activity;GO:0005764,cellular_component lysosome;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0007040,biological_process lysosome organization;GO:0007399,biological_process nervous system development;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0042474,biological_process middle ear morphogenesis;GO:0043202,cellular_component lysosomal lumen;GO:0045475,biological_process locomotor rhythm;GO:0046548,biological_process retinal rod cell development;GO:0060119,biological_process inner ear receptor cell development;GO:0070062,cellular_component extracellular exosome	NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50]; K01205	N-acetyl-alpha-glucosaminidase [Source:HGNC Symbol%3BAcc:HGNC:7632]
ENSG00000131127	4.51	5.54	4.22	3.51	2.87	3.85	0.475643037390305	2.66900586200811	0.00356442533411207	0.0601975669011335	4:337813-384864:+	ZNF141	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0035108,biological_process limb morphogenesis;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 141 [Source:HGNC Symbol%3BAcc:HGNC:12926]
ENSG00000204634	19.75	18.40	20.86	18.13	16.28	17.09	0.210419764908989	6.00069258980868	0.00357332937646716	0.0602659477582702	2:101007616-101252866:-	TBC1D8	10;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0008015,biological_process blood circulation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 8 [Source:HGNC Symbol%3BAcc:HGNC:17791]
ENSG00000132359	3.75	3.69	3.75	4.80	4.54	4.92	-0.338410842262132	3.34824016887711	0.00359854817153916	0.0606089259882166	17:2755704-3037739:+	RAP1GAP2	13;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008361,biological_process regulation of cell size;GO:0010977,biological_process negative regulation of neuron projection development;GO:0031965,cellular_component nuclear membrane;GO:0043005,cellular_component neuron projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	RAP1 GTPase activating protein 2 [Source:HGNC Symbol%3BAcc:HGNC:29176]
ENSG00000184716	12.37	12.61	12.47	10.72	10.77	9.98	0.262572350402932	4.20858618231758	0.00363083125526881	0.0610697945415335	15:43794161-43800221:-	SERINC4	6;GO:0006629,biological_process lipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015825,biological_process L-serine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	serine incorporator 4 [Source:HGNC Symbol%3BAcc:HGNC:32237]
ENSG00000110628	28.54	25.32	27.60	23.49	24.03	22.83	0.228701853109516	5.01633731885287	0.00364706149349866	0.0612152159974375	11:2899720-2925246:+	SLC22A18	19;GO:0005215,molecular_function transporter activity;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006855,biological_process drug transmembrane transport;GO:0007588,biological_process excretion;GO:0015238,molecular_function drug transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015307,molecular_function drug:proton antiporter activity;GO:0015695,biological_process organic cation transport;GO:0015893,biological_process drug transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0046618,biological_process drug export;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 22 member 18 [Source:HGNC Symbol%3BAcc:HGNC:10964]
ENSG00000153956	4.06	4.24	4.38	3.06	3.73	3.43	0.321792075102018	3.7021540594383	0.00364934019480414	0.0612152159974375	7:81946443-82443798:-	CACNA2D1	30;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0030315,cellular_component T-tubule;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0046872,molecular_function metal ion binding;GO:0051924,biological_process regulation of calcium ion transport;GO:0060307,biological_process regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060402,biological_process calcium ion transport into cytosol;GO:0061337,biological_process cardiac conduction;GO:0061577,biological_process calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086002,biological_process cardiac muscle cell action potential involved in contraction;GO:0086007,molecular_function voltage-gated calcium channel activity involved in cardiac muscle cell action potential;GO:0086048,biological_process membrane depolarization during bundle of His cell action potential;GO:0086057,molecular_function voltage-gated calcium channel activity involved in bundle of His cell action potential;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0098703,biological_process calcium ion import across plasma membrane;GO:0098903,biological_process regulation of membrane repolarization during action potential;GO:1901843,biological_process positive regulation of high voltage-gated calcium channel activity;GO:1990454,cellular_component L-type voltage-gated calcium channel complex	CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1; K04858	calcium voltage-gated channel auxiliary subunit alpha2delta 1 [Source:HGNC Symbol%3BAcc:HGNC:1399]
ENSG00000134243	29.27	30.31	30.41	26.05	27.68	25.97	0.186439880293813	6.16334795108819	0.00368209990899307	0.0616652022939999	1:109309567-109397951:-	SORT1	52;GO:0001503,biological_process ossification;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0006897,biological_process endocytosis;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008333,biological_process endosome to lysosome transport;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0010465,molecular_function nerve growth factor receptor activity;GO:0010468,biological_process regulation of gene expression;GO:0014902,biological_process myotube differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016050,biological_process vesicle organization;GO:0019899,molecular_function enzyme binding;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030154,biological_process cell differentiation;GO:0030379,molecular_function neurotensin receptor activity, non-G-protein coupled;GO:0030425,cellular_component dendrite;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031965,cellular_component nuclear membrane;GO:0032509,biological_process endosome transport via multivesicular body sorting pathway;GO:0032580,cellular_component Golgi cisterna membrane;GO:0032868,biological_process response to insulin;GO:0038180,biological_process nerve growth factor signaling pathway;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0046323,biological_process glucose import;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0048227,biological_process plasma membrane to endosome transport;GO:0048406,molecular_function nerve growth factor binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051005,biological_process negative regulation of lipoprotein lipase activity;GO:1904037,biological_process positive regulation of epithelial cell apoptotic process	SORT1; sortilin; K12388	sortilin 1 [Source:HGNC Symbol%3BAcc:HGNC:11186]
ENSG00000170412	37.95	35.91	35.93	30.93	32.00	34.09	0.190707847922035	6.13678339499242	0.00368610167583565	0.0616652022939999	17:74424850-74451653:+	GPRC5C	13;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0043235,cellular_component receptor complex;GO:0070062,cellular_component extracellular exosome	NA	G protein-coupled receptor class C group 5 member C [Source:HGNC Symbol%3BAcc:HGNC:13309]
ENSG00000185475	49.46	49.04	52.62	39.73	46.13	43.69	0.235286382748795	5.00658643284411	0.00369383177844732	0.0617113510980708	11:62787414-62790405:+	TMEM179B	9;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0030667,cellular_component secretory granule membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	transmembrane protein 179B [Source:HGNC Symbol%3BAcc:HGNC:33744]
ENSG00000130224	5.88	6.66	6.16	7.76	7.80	7.35	-0.287994238397641	4.0068605489413	0.00370272713994713	0.0617768171883921	X:115110615-115234072:-	LRCH2	2;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction	NA	leucine rich repeats and calponin homology domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29292]
ENSG00000060982	22.80	18.93	21.20	24.29	23.82	29.30	-0.282688692332658	4.90331717853542	0.00370976114629013	0.0618076248544353	12:24810021-24949459:-	BCAT1	20;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003824,molecular_function catalytic activity;GO:0004084,molecular_function branched-chain-amino-acid transaminase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0008152,biological_process metabolic process;GO:0008283,biological_process cell proliferation;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009081,biological_process branched-chain amino acid metabolic process;GO:0009082,biological_process branched-chain amino acid biosynthetic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0009098,biological_process leucine biosynthetic process;GO:0009099,biological_process valine biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0042802,molecular_function identical protein binding;GO:0052654,molecular_function L-leucine transaminase activity;GO:0052655,molecular_function L-valine transaminase activity;GO:0052656,molecular_function L-isoleucine transaminase activity	E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]; K00826	branched chain amino acid transaminase 1 [Source:HGNC Symbol%3BAcc:HGNC:976]
ENSG00000258653	1.97	2.66	1.88	3.30	3.79	3.51	-0.71380870023569	1.3836944935055	0.00371453219539263	0.0618076248544353	14:73851970-73932278:+	AC005520.1	NA	NA	NA
ENSG00000174804	6.97	7.71	7.08	6.23	5.13	5.76	0.351007137121857	3.39873270232793	0.00372680114034647	0.0618604944094664	11:86945678-86955391:-	FZD4	50;GO:0001540,molecular_function beta-amyloid binding;GO:0001553,biological_process luteinization;GO:0001568,biological_process blood vessel development;GO:0001570,biological_process vasculogenesis;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007275,biological_process multicellular organism development;GO:0007605,biological_process sensory perception of sound;GO:0009986,cellular_component cell surface;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0019955,molecular_function cytokine binding;GO:0030165,molecular_function PDZ domain binding;GO:0030182,biological_process neuron differentiation;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0030947,biological_process regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031987,biological_process locomotion involved in locomotory behavior;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035426,biological_process extracellular matrix-cell signaling;GO:0042701,biological_process progesterone secretion;GO:0042803,molecular_function protein homodimerization activity;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061024,biological_process membrane organization;GO:0061299,biological_process retina vasculature morphogenesis in camera-type eye;GO:0061301,biological_process cerebellum vasculature morphogenesis;GO:0061304,biological_process retinal blood vessel morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071300,biological_process cellular response to retinoic acid;GO:0106003,cellular_component amyloid-beta complex;GO:1990830,biological_process cellular response to leukemia inhibitory factor	FZD4, fz4, CD344; frizzled 4; K02354	frizzled class receptor 4 [Source:HGNC Symbol%3BAcc:HGNC:4042]
ENSG00000108797	21.28	20.51	23.88	18.38	20.00	18.77	0.21414861858158	6.41285289464383	0.00372767661470079	0.0618604944094664	17:42682612-42699814:+	CNTNAP1	27;GO:0002175,biological_process protein localization to paranode region of axon;GO:0004872,molecular_function receptor activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0009967,biological_process positive regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017124,molecular_function SH3 domain binding;GO:0019227,biological_process neuronal action potential propagation;GO:0022010,biological_process central nervous system myelination;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030913,biological_process paranodal junction assembly;GO:0031175,biological_process neuron projection development;GO:0033010,cellular_component paranodal junction;GO:0033270,cellular_component paranode region of axon;GO:0043209,cellular_component myelin sheath;GO:0048812,biological_process neuron projection morphogenesis;GO:0050884,biological_process neuromuscular process controlling posture;GO:0050885,biological_process neuromuscular process controlling balance;GO:0071205,biological_process protein localization to juxtaparanode region of axon	CNTNAP1; contactin associated protein 1; K07379	contactin associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8011]
ENSG00000102034	15.94	15.71	15.62	13.89	13.88	13.15	0.220727217431753	4.87631009150007	0.0037374437266749	0.0619397716678444	X:130064873-130110716:-	ELF4	20;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001787,biological_process natural killer cell proliferation;GO:0001866,biological_process NK T cell proliferation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045087,biological_process innate immune response;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	ELF1_2_4; E74-like factor 1/2/4; K09428	E74 like ETS transcription factor 4 [Source:HGNC Symbol%3BAcc:HGNC:3319]
ENSG00000100350	7.43	7.54	7.07	6.09	6.51	4.97	0.340185895746097	3.77080013534229	0.00374520615845009	0.0619856587264546	22:36487189-36507101:-	FOXRED2	7;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0016491,molecular_function oxidoreductase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	FAD dependent oxidoreductase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26264]
ENSG00000113300	15.55	16.93	14.05	17.97	19.11	18.56	-0.252049311747199	4.83840491138576	0.00375473207443932	0.0619915200653009	5:180494411-180578405:+	CNOT6	27;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004532,molecular_function exoribonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010606,biological_process positive regulation of cytoplasmic mRNA processing body assembly;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030014,cellular_component CCR4-NOT complex;GO:0031047,biological_process gene silencing by RNA;GO:0035195,biological_process gene silencing by miRNA;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046872,molecular_function metal ion binding;GO:0070966,biological_process nuclear-transcribed mRNA catabolic process, no-go decay;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:2000327,biological_process positive regulation of ligand-dependent nuclear receptor transcription coactivator activity	CNOT6, CCR4; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]; K12603	CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:14099]
ENSG00000187266	8.64	9.76	9.65	7.69	8.02	7.47	0.282335438134586	4.05726040020609	0.00375554846444101	0.0619915200653009	19:11377204-11384342:-	EPOR	16;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004896,molecular_function cytokine receptor activity;GO:0004900,molecular_function erythropoietin receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0038162,biological_process erythropoietin-mediated signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0046697,biological_process decidualization	EPOR; erythropoietin receptor; K05079	erythropoietin receptor [Source:HGNC Symbol%3BAcc:HGNC:3416]
ENSG00000104852	148.19	148.00	150.95	130.04	136.96	132.99	0.172668378313898	7.55930834140677	0.00378655216309666	0.0624126350863736	19:49085418-49108605:+	SNRNP70	28;GO:0000243,cellular_component commitment complex;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005685,cellular_component U1 snRNP;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030619,molecular_function U1 snRNA binding;GO:0043462,biological_process regulation of ATPase activity;GO:0043484,biological_process regulation of RNA splicing;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0061084,biological_process negative regulation of protein refolding;GO:0071004,cellular_component U2-type prespliceosome;GO:0071011,cellular_component precatalytic spliceosome;GO:0071300,biological_process cellular response to retinoic acid;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1904715,biological_process negative regulation of chaperone-mediated autophagy;GO:1990446,molecular_function U1 snRNP binding	SNRP70; U1 small nuclear ribonucleoprotein 70kDa; K11093	small nuclear ribonucleoprotein U1 subunit 70 [Source:HGNC Symbol%3BAcc:HGNC:11150]
ENSG00000243147	151.64	146.31	140.10	171.09	163.37	168.44	-0.187394346691147	6.09694423773627	0.00379111631798322	0.0624126350863736	2:27771716-27988087:+	MRPL33	10;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33; K02913	mitochondrial ribosomal protein L33 [Source:HGNC Symbol%3BAcc:HGNC:14487]
ENSG00000110917	83.78	98.91	90.13	75.29	85.34	72.86	0.234155628698102	6.22550773246575	0.00383651852571596	0.0630764297479632	12:120686868-120701864:+	MLEC	11;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0030246,molecular_function carbohydrate binding;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation	NA	malectin [Source:HGNC Symbol%3BAcc:HGNC:28973]
ENSG00000135454	2.25	2.61	1.78	1.20	1.29	1.77	0.632982658645463	1.864138052989	0.00386229479914043	0.0633057161431816	12:57623409-57633355:-	B4GALNT1	19;GO:0000139,cellular_component Golgi membrane;GO:0001574,biological_process ganglioside biosynthetic process;GO:0003947,molecular_function (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0007283,biological_process spermatogenesis;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0019915,biological_process lipid storage;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030259,biological_process lipid glycosylation	B4GALNT1, GALGT; (N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase [EC:2.4.1.92]; K00725	beta-1%2C4-N-acetyl-galactosaminyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:4117]
ENSG00000133321	78.26	58.44	80.07	97.38	78.53	97.64	-0.319202633735026	5.60755104752858	0.00386365805156253	0.0633057161431816	11:63536808-63546462:+	RARRES3	12;GO:0004623,molecular_function phospholipase A2 activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016787,molecular_function hydrolase activity;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling	NA	retinoic acid receptor responder 3 [Source:HGNC Symbol%3BAcc:HGNC:9869]
ENSG00000135917	1.58	2.82	2.13	1.47	1.29	1.11	0.737149088588417	1.44885549325385	0.00386905031366289	0.0633057161431816	2:227685209-227718012:-	SLC19A3	9;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015234,molecular_function thiamine transmembrane transporter activity;GO:0015403,molecular_function thiamine uptake transmembrane transporter activity;GO:0015888,biological_process thiamine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042723,biological_process thiamine-containing compound metabolic process;GO:0071934,biological_process thiamine transmembrane transport	SLC19A2_3, THTR; solute carrier family 19 (thiamine transporter), member 2/3; K14610	solute carrier family 19 member 3 [Source:HGNC Symbol%3BAcc:HGNC:16266]
ENSG00000114738	107.63	112.73	117.62	136.23	123.45	130.03	-0.193917423482138	7.12283620037727	0.00387820479246765	0.0633057161431816	3:50611519-50649297:+	MAPKAPK3	31;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0009931,molecular_function calcium-dependent protein serine/threonine kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032496,biological_process response to lipopolysaccharide;GO:0034097,biological_process response to cytokine;GO:0044351,biological_process macropinocytosis;GO:0046777,biological_process protein autophosphorylation;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0051019,molecular_function mitogen-activated protein kinase binding	MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]; K04444	mitogen-activated protein kinase-activated protein kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:6888]
ENSG00000167996	11194.24	10983.52	11570.53	9862.77	10076.02	10436.31	0.163808484490934	13.0208494316077	0.00387940311769266	0.0633057161431816	11:61959717-61967660:-	FTH1	25;GO:0004322,molecular_function ferroxidase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006826,biological_process iron ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006880,biological_process intracellular sequestering of iron ion;GO:0006955,biological_process immune response;GO:0008043,cellular_component intracellular ferritin complex;GO:0008199,molecular_function ferric iron binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0043312,biological_process neutrophil degranulation;GO:0044754,cellular_component autolysosome;GO:0046872,molecular_function metal ion binding;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	FTH1; ferritin heavy chain [EC:1.16.3.2]; K00522	ferritin heavy chain 1 [Source:HGNC Symbol%3BAcc:HGNC:3976]
ENSG00000167994	2.49	1.65	1.96	2.75	3.44	3.19	-0.585048727754112	1.91892985415995	0.00388106420566835	0.0633057161431816	11:61897300-61920269:-	RAB3IL1	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	RAB3A interacting protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:9780]
ENSG00000176978	76.50	75.51	80.58	65.38	68.52	71.99	0.187976003940933	6.9765106581855	0.00390397164054462	0.0634866192000241	9:137110541-137115177:-	DPP7	16;GO:0004177,molecular_function aminopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008239,molecular_function dipeptidyl-peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0035578,cellular_component azurophil granule lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	dipeptidyl peptidase 7 [Source:HGNC Symbol%3BAcc:HGNC:14892]
ENSG00000172543	0.77	0.48	0.67	1.81	0.76	1.58	-1.0702167316207	0.477184751973374	0.00390431088854328	0.0634866192000241	11:65879808-65883741:+	CTSW	13;GO:0002576,biological_process platelet degranulation;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0006955,biological_process immune response;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031089,cellular_component platelet dense granule lumen;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process	CTSW; cathepsin W [EC:3.4.22.-]; K08569	cathepsin W [Source:HGNC Symbol%3BAcc:HGNC:2546]
ENSG00000028203	23.73	24.30	25.69	28.58	26.80	29.79	-0.196588103232447	6.11262564072851	0.00391088317220443	0.0634866192000241	12:95217745-95302790:+	VEZT	12;GO:0001669,cellular_component acrosomal vesicle;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0017022,molecular_function myosin binding;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle	NA	vezatin%2C adherens junctions transmembrane protein [Source:HGNC Symbol%3BAcc:HGNC:18258]
ENSG00000109762	6.31	7.28	6.83	7.84	8.43	8.54	-0.27623895716875	4.2601469495094	0.00391261288069108	0.0634866192000241	4:185204236-185370185:+	SNX25	13;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032801,biological_process receptor catabolic process;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0060394,biological_process negative regulation of pathway-restricted SMAD protein phosphorylation	NA	sorting nexin 25 [Source:HGNC Symbol%3BAcc:HGNC:21883]
ENSG00000181744	9.47	7.67	8.07	6.01	7.12	6.60	0.372808873821443	3.40787650561456	0.0039287541452158	0.0636653070555662	3:143971797-144048719:+	C3orf58	9;GO:0000139,cellular_component Golgi membrane;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0030126,cellular_component COPI vesicle coat;GO:0030137,cellular_component COPI-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0060038,biological_process cardiac muscle cell proliferation	NA	chromosome 3 open reading frame 58 [Source:HGNC Symbol%3BAcc:HGNC:28490]
ENSG00000162878	21.39	23.07	22.99	15.49	21.54	18.11	0.301611415393681	4.92202036694892	0.00395398095081177	0.0639312384918863	2:42048019-42058528:+	PKDCC	27;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0006810,biological_process transport;GO:0007275,biological_process multicellular organism development;GO:0015031,biological_process protein transport;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030282,biological_process bone mineralization;GO:0030501,biological_process positive regulation of bone mineralization;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0035108,biological_process limb morphogenesis;GO:0035264,biological_process multicellular organism growth;GO:0042997,biological_process negative regulation of Golgi to plasma membrane protein transport;GO:0048286,biological_process lung alveolus development;GO:0048566,biological_process embryonic digestive tract development;GO:0060021,biological_process palate development	NA	protein kinase domain containing%2C cytoplasmic [Source:HGNC Symbol%3BAcc:HGNC:25123]
ENSG00000101811	9.96	8.97	10.75	11.92	12.24	11.96	-0.263934782819193	4.33738623658221	0.00395674339441023	0.0639312384918863	X:100820358-100840932:+	CSTF2	17;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0016604,cellular_component nuclear body;GO:0031124,biological_process mRNA 3'-end processing;GO:0071920,cellular_component cleavage body;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation;GO:1990090,biological_process cellular response to nerve growth factor stimulus	CSTF2, RNA15; cleavage stimulation factor subunit 2; K14407	cleavage stimulation factor subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:2484]
ENSG00000168434	13.01	14.09	12.96	11.22	11.09	12.13	0.224702733981858	4.94693591283495	0.00396061567713369	0.0639312384918863	16:23388492-23453180:-	COG7	17;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032588,cellular_component trans-Golgi network membrane;GO:0033365,biological_process protein localization to organelle;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0050821,biological_process protein stabilization	NA	component of oligomeric golgi complex 7 [Source:HGNC Symbol%3BAcc:HGNC:18622]
ENSG00000171813	2.58	2.63	2.48	2.06	1.02	1.90	0.630990412665353	1.96039113259071	0.00398678006936079	0.0642700012999682	10:132397167-132417863:+	PWWP2B	2;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm	NA	PWWP domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:25150]
ENSG00000179335	18.71	19.26	17.63	16.63	15.62	16.21	0.207210076278076	5.28286181311765	0.0039943310762323	0.0643056985323875	15:74598499-74645414:+	CLK3	24;GO:0000166,molecular_function nucleotide binding;GO:0001669,cellular_component acrosomal vesicle;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042802,molecular_function identical protein binding;GO:0043484,biological_process regulation of RNA splicing;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0046777,biological_process protein autophosphorylation	NA	CDC like kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:2071]
ENSG00000142949	76.87	72.03	77.12	87.34	83.49	85.78	-0.171040058878166	8.88277877639236	0.00399935545532934	0.0643056985323875	1:43525186-43623666:+	PTPRF	25;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007155,biological_process cell adhesion;GO:0007185,biological_process transmembrane receptor protein tyrosine phosphatase signaling pathway;GO:0008201,molecular_function heparin binding;GO:0010975,biological_process regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0031102,biological_process neuron projection regeneration;GO:0032403,molecular_function protein complex binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035373,molecular_function chondroitin sulfate proteoglycan binding;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0048679,biological_process regulation of axon regeneration;GO:0070062,cellular_component extracellular exosome;GO:1900121,biological_process negative regulation of receptor binding	PTPRF, LAR; receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48]; K05695	protein tyrosine phosphatase%2C receptor type F [Source:HGNC Symbol%3BAcc:HGNC:9670]
ENSG00000126709	65.00	80.10	52.27	46.12	49.28	56.73	0.379980602135543	4.59156274838863	0.00402087669688682	0.0645681014727763	1:27666060-27672218:-	IFI6	11;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0051902,biological_process negative regulation of mitochondrial depolarization;GO:0060337,biological_process type I interferon signaling pathway;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	interferon alpha inducible protein 6 [Source:HGNC Symbol%3BAcc:HGNC:4054]
ENSG00000178445	0.21	0.34	0.20	0.31	0.84	0.49	-1.13200580115039	0.567685240653431	0.00402878179028653	0.0646114578331094	9:6532463-6645783:-	GLDC	24;GO:0003824,molecular_function catalytic activity;GO:0004375,molecular_function glycine dehydrogenase (decarboxylating) activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0005960,cellular_component glycine cleavage complex;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006544,biological_process glycine metabolic process;GO:0006546,biological_process glycine catabolic process;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016594,molecular_function glycine binding;GO:0016829,molecular_function lyase activity;GO:0019464,biological_process glycine decarboxylation via glycine cleavage system;GO:0019899,molecular_function enzyme binding;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0036255,biological_process response to methylamine;GO:0042803,molecular_function protein homodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0055114,biological_process oxidation-reduction process;GO:0070280,molecular_function pyridoxal binding;GO:1903442,biological_process response to lipoic acid;GO:1990830,biological_process cellular response to leukemia inhibitory factor	GLDC, gcvP; glycine dehydrogenase [EC:1.4.4.2]; K00281	glycine decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:4313]
ENSG00000165730	0.21	0.16	0.40	0.38	0.69	0.57	-1.02976889085083	0.450959662247937	0.00404731548915797	0.064824938279894	10:68827540-68895432:+	STOX1	36;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010821,biological_process regulation of mitochondrion organization;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0045787,biological_process positive regulation of cell cycle;GO:0048839,biological_process inner ear development;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051301,biological_process cell division;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0071500,biological_process cellular response to nitrosative stress;GO:1901858,biological_process regulation of mitochondrial DNA metabolic process;GO:1902882,biological_process regulation of response to oxidative stress;GO:1904031,biological_process positive regulation of cyclin-dependent protein kinase activity;GO:1904120,biological_process positive regulation of otic vesicle morphogenesis	NA	storkhead box 1 [Source:HGNC Symbol%3BAcc:HGNC:23508]
ENSG00000116521	59.84	58.48	56.14	49.20	53.91	50.73	0.193274076572571	5.8356093168412	0.00408799464218643	0.0653921101719847	1:155255978-155262430:-	SCAMP3	8;GO:0006810,biological_process transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome	NA	secretory carrier membrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:10565]
ENSG00000151835	4.85	5.03	4.65	4.09	4.41	4.34	0.188894217466848	5.9788546758307	0.00409644207964611	0.0654429028759937	13:23328825-23411513:-	SACS	11;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006457,biological_process protein folding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030544,molecular_function Hsp70 protein binding;GO:0051087,molecular_function chaperone binding;GO:0070628,molecular_function proteasome binding;GO:0070852,cellular_component cell body fiber;GO:0090084,biological_process negative regulation of inclusion body assembly	NA	sacsin molecular chaperone [Source:HGNC Symbol%3BAcc:HGNC:10519]
ENSG00000183856	25.65	24.77	25.56	30.14	28.77	27.97	-0.181117479587727	7.05618366279345	0.00410752409341753	0.0655146272493059	1:156525404-156572604:-	IQGAP3	20;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000187,biological_process activation of MAPK activity;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005911,cellular_component cell-cell junction;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0008361,biological_process regulation of cell size;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016328,cellular_component lateral plasma membrane;GO:0017016,molecular_function Ras GTPase binding;GO:0017048,molecular_function Rho GTPase binding;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0043087,biological_process regulation of GTPase activity;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070856,molecular_function myosin VI light chain binding;GO:0071310,biological_process cellular response to organic substance	IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3; K05767	IQ motif containing GTPase activating protein 3 [Source:HGNC Symbol%3BAcc:HGNC:20669]
ENSG00000277443	79.63	80.41	75.52	88.63	87.19	94.89	-0.190134241688801	6.39686502328121	0.00411555288943636	0.0655146272493059	6:113857361-113863471:+	MARCKS	20;GO:0003779,molecular_function actin binding;GO:0005080,molecular_function protein kinase C binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0032432,cellular_component actin filament bundle;GO:0042585,cellular_component germinal vesicle;GO:0042802,molecular_function identical protein binding;GO:0050796,biological_process regulation of insulin secretion;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051260,biological_process protein homooligomerization;GO:0051764,biological_process actin crosslink formation;GO:0070062,cellular_component extracellular exosome	MARCKS; myristoylated alanine-rich C-kinase substrate; K12561	myristoylated alanine rich protein kinase C substrate [Source:HGNC Symbol%3BAcc:HGNC:6759]
ENSG00000125968	40.54	44.64	35.89	49.30	48.38	49.19	-0.27476634082648	4.44994756991231	0.00411676542773372	0.0655146272493059	20:31605282-31606515:+	ID1	59;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001525,biological_process angiogenesis;GO:0001886,biological_process endothelial cell morphogenesis;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007623,biological_process circadian rhythm;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0010621,biological_process negative regulation of transcription by transcription factor localization;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0030182,biological_process neuron differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0031648,biological_process protein destabilization;GO:0032091,biological_process negative regulation of protein binding;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0032963,biological_process collagen metabolic process;GO:0036164,biological_process cell-abiotic substrate adhesion;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043392,biological_process negative regulation of DNA binding;GO:0043408,biological_process regulation of MAPK cascade;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043534,biological_process blood vessel endothelial cell migration;GO:0043621,molecular_function protein self-association;GO:0045602,biological_process negative regulation of endothelial cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045765,biological_process regulation of angiogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046677,biological_process response to antibiotic;GO:0046983,molecular_function protein dimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048511,biological_process rhythmic process;GO:0048514,biological_process blood vessel morphogenesis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050774,biological_process negative regulation of dendrite morphogenesis;GO:0060425,biological_process lung morphogenesis;GO:0060426,biological_process lung vasculature development;GO:0070628,molecular_function proteasome binding;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090074,biological_process negative regulation of protein homodimerization activity;GO:1901342,biological_process regulation of vasculature development;GO:1901653,biological_process cellular response to peptide;GO:1903026,biological_process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:1903351,biological_process cellular response to dopamine;GO:1990090,biological_process cellular response to nerve growth factor stimulus	ID1; DNA-binding protein inhibitor ID1; K04680	inhibitor of DNA binding 1%2C HLH protein [Source:HGNC Symbol%3BAcc:HGNC:5360]
ENSG00000071889	34.35	30.85	31.22	25.64	26.80	29.60	0.246659169652409	4.7785287080593	0.00415897025862643	0.0661015337008065	X:154506158-154516242:-	FAM3A	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019732,biological_process antifungal humoral response;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide;GO:1905035,biological_process negative regulation of antifungal innate immune response	NA	family with sequence similarity 3 member A [Source:HGNC Symbol%3BAcc:HGNC:13749]
ENSG00000104549	95.35	117.60	85.51	72.24	93.04	74.77	0.325113099928345	7.37402190940648	0.00416759092618553	0.0661538442029937	8:124998496-125022283:+	SQLE	17;GO:0004506,molecular_function squalene monooxygenase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006725,biological_process cellular aromatic compound metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0010033,biological_process response to organic substance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	SQLE, ERG1; squalene monooxygenase [EC:1.14.14.17]; K00511	squalene epoxidase [Source:HGNC Symbol%3BAcc:HGNC:11279]
ENSG00000167766	94.86	85.45	100.73	79.81	77.39	87.42	0.212963080368894	7.56275741523455	0.00418109503906223	0.0662781847431117	19:52594059-52690496:-	ZNF83	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 83 [Source:HGNC Symbol%3BAcc:HGNC:13158]
ENSG00000173011	17.04	15.24	14.90	19.43	18.24	19.09	-0.251628335458688	4.46239377610232	0.00418985852365085	0.0662781847431117	4:7041898-7057952:+	TADA2B	20;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0016573,biological_process histone acetylation;GO:0016579,biological_process protein deubiquitination;GO:0030914,cellular_component STAGA complex;GO:0035065,biological_process regulation of histone acetylation;GO:0035066,biological_process positive regulation of histone acetylation;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070461,cellular_component SAGA-type complex	NA	transcriptional adaptor 2B [Source:HGNC Symbol%3BAcc:HGNC:30781]
ENSG00000203485	42.44	41.78	41.90	37.97	37.22	37.92	0.168915911503524	7.38985282862722	0.00419144244125858	0.0662781847431117	14:104689605-104722535:+	INF2	7;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090140,biological_process regulation of mitochondrial fission	NA	inverted formin%2C FH2 and WH2 domain containing [Source:HGNC Symbol%3BAcc:HGNC:23791]
ENSG00000172932	13.71	14.03	14.41	12.62	11.59	11.82	0.237994242620305	4.59048666508066	0.00420198848283576	0.0662953481681778	11:67288546-67302485:+	ANKRD13D	5;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	ankyrin repeat domain 13D [Source:HGNC Symbol%3BAcc:HGNC:27880]
ENSG00000184110	6.27	5.41	6.91	7.63	8.22	7.27	-0.293551822759543	4.26882782298679	0.00420320945849963	0.0662953481681778	16:28688557-28735730:+	EIF3C	15;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0031369,molecular_function translation initiation factor binding;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0045727,biological_process positive regulation of translation;GO:1902416,biological_process positive regulation of mRNA binding	EIF3C; translation initiation factor 3 subunit C; K03252	eukaryotic translation initiation factor 3 subunit C [Source:HGNC Symbol%3BAcc:HGNC:3279]
ENSG00000173327	25.93	26.26	25.29	21.34	22.21	24.55	0.19637798870149	5.95122866271416	0.0042274229810579	0.0665926414516138	11:65597754-65615382:-	MAP3K11	37;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004706,molecular_function JUN kinase kinase kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006468,biological_process protein phosphorylation;GO:0007017,biological_process microtubule-based process;GO:0007254,biological_process JNK cascade;GO:0007256,biological_process activation of JNKK activity;GO:0007257,biological_process activation of JUN kinase activity;GO:0008219,biological_process cell death;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation;GO:0048365,molecular_function Rac GTPase binding	MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]; K04419	mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol%3BAcc:HGNC:6850]
ENSG00000153253	0.37	0.49	0.41	0.20	0.26	0.30	0.729227929857162	1.12497780908538	0.00423960403459684	0.0666998794441705	2:165087521-165204067:-	SCN3A	19;GO:0001518,cellular_component voltage-gated sodium channel complex;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005248,molecular_function voltage-gated sodium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019228,biological_process neuronal action potential;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0086010,biological_process membrane depolarization during action potential	SCN3A, NAV1.3; voltage-gated sodium channel type III alpha; K04836	sodium voltage-gated channel alpha subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:10590]
ENSG00000091651	24.20	20.10	18.30	25.95	26.08	26.23	-0.30620826973833	4.16754438672931	0.00424921555810395	0.066709908811574	16:46689642-46698394:+	ORC6	13;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000808,cellular_component origin recognition complex;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003688,molecular_function DNA replication origin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0016020,cellular_component membrane;GO:0051782,biological_process negative regulation of cell division	ORC6; origin recognition complex subunit 6; K02608	origin recognition complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:17151]
ENSG00000221866	0.28	0.32	0.34	0.16	0.13	0.22	0.878648845853411	0.675099853664714	0.00425098991943568	0.066709908811574	7:132123331-132648688:-	PLXNA4	26;GO:0002116,cellular_component semaphorin receptor complex;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0008045,biological_process motor neuron axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0021602,biological_process cranial nerve morphogenesis;GO:0021610,biological_process facial nerve morphogenesis;GO:0021612,biological_process facial nerve structural organization;GO:0021615,biological_process glossopharyngeal nerve morphogenesis;GO:0021636,biological_process trigeminal nerve morphogenesis;GO:0021637,biological_process trigeminal nerve structural organization;GO:0021644,biological_process vagus nerve morphogenesis;GO:0021784,biological_process postganglionic parasympathetic fiber development;GO:0021785,biological_process branchiomotor neuron axon guidance;GO:0021793,biological_process chemorepulsion of branchiomotor axon;GO:0021960,biological_process anterior commissure morphogenesis;GO:0048485,biological_process sympathetic nervous system development;GO:0048812,biological_process neuron projection morphogenesis;GO:0048841,biological_process regulation of axon extension involved in axon guidance;GO:0050923,biological_process regulation of negative chemotaxis;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:1902287,biological_process semaphorin-plexin signaling pathway involved in axon guidance	PLXNA; plexin A; K06820	plexin A4 [Source:HGNC Symbol%3BAcc:HGNC:9102]
ENSG00000175792	44.72	46.85	46.70	54.73	51.88	51.71	-0.184448711496003	6.30489651237453	0.0042756137599645	0.0670116080838881	3:128064777-128153914:-	RUVBL1	50;GO:0000166,molecular_function nucleotide binding;GO:0000492,biological_process box C/D snoRNP assembly;GO:0000812,cellular_component Swr1 complex;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0003678,molecular_function DNA helicase activity;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031011,cellular_component Ino80 complex;GO:0032508,biological_process DNA duplex unwinding;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043141,molecular_function ATP-dependent 5'-3' DNA helicase activity;GO:0043531,molecular_function ADP binding;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0045296,molecular_function cadherin binding;GO:0051117,molecular_function ATPase binding;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0071339,cellular_component MLL1 complex;GO:0097255,cellular_component R2TP complex;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	RuvB like AAA ATPase 1 [Source:HGNC Symbol%3BAcc:HGNC:10474]
ENSG00000155254	8.71	7.92	10.49	12.26	11.69	13.96	-0.462130319488137	2.54324178491881	0.00429669556744186	0.0672571022429456	10:97713172-97718152:+	MARVELD1	12;GO:0001766,biological_process membrane raft polarization;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0008104,biological_process protein localization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019911,molecular_function structural constituent of myelin sheath;GO:0042552,biological_process myelination;GO:0045121,cellular_component membrane raft	NA	MARVEL domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28674]
ENSG00000144857	1.37	1.42	1.15	0.73	1.04	0.94	0.545710395333966	2.00263539633362	0.00432956123716368	0.0676862010540462	3:113211002-113287459:+	BOC	11;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007224,biological_process smoothened signaling pathway;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0044295,cellular_component axonal growth cone;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation	NA	BOC cell adhesion associated%2C oncogene regulated [Source:HGNC Symbol%3BAcc:HGNC:17173]
ENSG00000198203	96.60	99.11	107.28	84.22	94.34	86.85	0.203304776753547	6.60425030731414	0.00434625274984546	0.0678616797280901	2:108288638-108309915:+	SULT1C2	10;GO:0004062,molecular_function aryl sulfotransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008146,molecular_function sulfotransferase activity;GO:0009308,biological_process amine metabolic process;GO:0016740,molecular_function transferase activity;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0051923,biological_process sulfation;GO:0070062,cellular_component extracellular exosome	NA	sulfotransferase family 1C member 2 [Source:HGNC Symbol%3BAcc:HGNC:11456]
ENSG00000175387	36.06	37.25	37.09	41.11	41.55	43.56	-0.182775732612304	5.89744429906144	0.00437063336644653	0.0681566230875638	18:47808956-47931146:-	SMAD2	91;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001657,biological_process ureteric bud development;GO:0001701,biological_process in utero embryonic development;GO:0001706,biological_process endoderm formation;GO:0001707,biological_process mesoderm formation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007182,biological_process common-partner SMAD protein phosphorylation;GO:0007183,biological_process SMAD protein complex assembly;GO:0007352,biological_process zygotic specification of dorsal/ventral axis;GO:0007369,biological_process gastrulation;GO:0007389,biological_process pattern specification process;GO:0007492,biological_process endoderm development;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009749,biological_process response to glucose;GO:0009791,biological_process post-embryonic development;GO:0009880,biological_process embryonic pattern specification;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016579,biological_process protein deubiquitination;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0019902,molecular_function phosphatase binding;GO:0023019,biological_process signal transduction involved in regulation of gene expression;GO:0030073,biological_process insulin secretion;GO:0030324,biological_process lung development;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030618,molecular_function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity;GO:0031016,biological_process pancreas development;GO:0031053,biological_process primary miRNA processing;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032444,cellular_component activin responsive factor complex;GO:0032924,biological_process activin receptor signaling pathway;GO:0033613,molecular_function activating transcription factor binding;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035265,biological_process organ growth;GO:0035326,molecular_function enhancer binding;GO:0035556,biological_process intracellular signal transduction;GO:0038092,biological_process nodal signaling pathway;GO:0042060,biological_process wound healing;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0045165,biological_process cell fate commitment;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048340,biological_process paraxial mesoderm morphogenesis;GO:0048589,biological_process developmental growth;GO:0048617,biological_process embryonic foregut morphogenesis;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0051098,biological_process regulation of binding;GO:0060021,biological_process palate development;GO:0060039,biological_process pericardium development;GO:0060395,biological_process SMAD protein signal transduction;GO:0070410,molecular_function co-SMAD binding;GO:0070411,molecular_function I-SMAD binding;GO:0070412,molecular_function R-SMAD binding;GO:0070723,biological_process response to cholesterol;GO:0070878,molecular_function primary miRNA binding;GO:0071141,cellular_component SMAD protein complex;GO:0071144,cellular_component SMAD2-SMAD3 protein complex;GO:0097718,molecular_function disordered domain specific binding;GO:1900224,biological_process positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	SMAD2; mothers against decapentaplegic homolog 2; K04500	SMAD family member 2 [Source:HGNC Symbol%3BAcc:HGNC:6768]
ENSG00000164985	89.34	82.11	86.95	98.73	95.27	101.05	-0.178451266815925	7.29411949523473	0.00437865554360318	0.068165427866163	9:15464065-15511019:-	PSIP1	16;GO:0000395,biological_process mRNA 5'-splice site recognition;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006979,biological_process response to oxidative stress;GO:0009408,biological_process response to heat;GO:0016032,biological_process viral process;GO:0035327,cellular_component transcriptionally active chromatin;GO:0051169,biological_process nuclear transport;GO:0075713,biological_process establishment of integrated proviral latency;GO:0097100,molecular_function supercoiled DNA binding	NA	PC4 and SFRS1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9527]
ENSG00000173890	62.69	63.52	60.46	70.96	76.22	68.17	-0.19484663290404	6.09049255764456	0.00438218089399807	0.068165427866163	3:170037928-170085403:+	GPR160	8;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043235,cellular_component receptor complex	NA	G protein-coupled receptor 160 [Source:HGNC Symbol%3BAcc:HGNC:23693]
ENSG00000163931	838.70	927.63	822.44	722.98	812.26	733.19	0.20230564181167	10.6184554899324	0.00439407418313378	0.0682137267708462	3:53224706-53256052:-	TKT	21;GO:0003824,molecular_function catalytic activity;GO:0004802,molecular_function transketolase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0005999,biological_process xylulose biosynthetic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0008152,biological_process metabolic process;GO:0009052,biological_process pentose-phosphate shunt, non-oxidative branch;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031982,cellular_component vesicle;GO:0040008,biological_process regulation of growth;GO:0042803,molecular_function protein homodimerization activity;GO:0043209,cellular_component myelin sheath;GO:0046166,biological_process glyceraldehyde-3-phosphate biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0048037,molecular_function cofactor binding;GO:0070062,cellular_component extracellular exosome	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]; K00615	transketolase [Source:HGNC Symbol%3BAcc:HGNC:11834]
ENSG00000171903	16.17	16.96	15.59	14.67	13.51	13.20	0.244846646099416	4.56739794941729	0.00439690499898181	0.0682137267708462	19:15912366-15934867:-	CYP4F11	21;GO:0004497,molecular_function monooxygenase activity;GO:0005504,molecular_function fatty acid binding;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006631,biological_process fatty acid metabolic process;GO:0006954,biological_process inflammatory response;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016709,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0042361,biological_process menaquinone catabolic process;GO:0042376,biological_process phylloquinone catabolic process;GO:0042377,biological_process vitamin K catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome P450 family 4 subfamily F member 11 [Source:HGNC Symbol%3BAcc:HGNC:13265]
ENSG00000189007	12.33	9.34	11.05	14.37	16.15	13.74	-0.407947636732785	2.91854903397319	0.00440851573294371	0.0682137267708462	6:143422831-143450673:-	ADAT2	12;GO:0002100,biological_process tRNA wobble adenosine to inosine editing;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008251,molecular_function tRNA-specific adenosine deaminase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0052717,molecular_function tRNA-specific adenosine-34 deaminase activity;GO:0052718,cellular_component tRNA-specific adenosine-34 deaminase complex	NA	adenosine deaminase%2C tRNA specific 2 [Source:HGNC Symbol%3BAcc:HGNC:21172]
ENSG00000188897	0.20	0.25	0.29	0.20	0.13	0.09	0.831883688632647	1.02964217300099	0.00441370948960931	0.0682137267708462	16:11359844-11523588:-	AC099489.1	2;GO:0005319,molecular_function lipid transporter activity;GO:0006869,biological_process lipid transport	NA	NA
ENSG00000101337	44.86	45.63	43.21	52.47	50.43	50.14	-0.184034130423369	6.54705431527522	0.00441440298416055	0.0682137267708462	20:32109505-32167258:+	TM9SF4	13;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006909,biological_process phagocytosis;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051453,biological_process regulation of intracellular pH;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly;GO:0070863,biological_process positive regulation of protein exit from endoplasmic reticulum;GO:2000010,biological_process positive regulation of protein localization to cell surface	NA	transmembrane 9 superfamily member 4 [Source:HGNC Symbol%3BAcc:HGNC:30797]
ENSG00000069399	35.96	32.80	35.20	41.70	37.71	41.19	-0.199883429612403	5.74102327776921	0.00442152055249697	0.0682137267708462	19:44747704-44760044:+	BCL3	50;GO:0000060,biological_process protein import into nucleus, translocation;GO:0002268,biological_process follicular dendritic cell differentiation;GO:0002315,biological_process marginal zone B cell differentiation;GO:0002455,biological_process humoral immune response mediated by circulating immunoglobulin;GO:0002467,biological_process germinal center formation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0008134,molecular_function transcription factor binding;GO:0009615,biological_process response to virus;GO:0010225,biological_process response to UV-C;GO:0019730,biological_process antimicrobial humoral response;GO:0030198,biological_process extracellular matrix organization;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0030496,cellular_component midbody;GO:0030674,molecular_function protein binding, bridging;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032996,cellular_component Bcl3-Bcl10 complex;GO:0033257,cellular_component Bcl3/NF-kappaB2 complex;GO:0042088,biological_process T-helper 1 type immune response;GO:0042345,biological_process regulation of NF-kappaB import into nucleus;GO:0042536,biological_process negative regulation of tumor necrosis factor biosynthetic process;GO:0042742,biological_process defense response to bacterium;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042832,biological_process defense response to protozoan;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045064,biological_process T-helper 2 cell differentiation;GO:0045082,biological_process positive regulation of interleukin-10 biosynthetic process;GO:0045415,biological_process negative regulation of interleukin-8 biosynthetic process;GO:0045727,biological_process positive regulation of translation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048536,biological_process spleen development;GO:0051101,biological_process regulation of DNA binding;GO:0051457,biological_process maintenance of protein location in nucleus	BCL3; B-cell CLL/lymphoma protein 3; K09258	B-cell CLL/lymphoma 3 [Source:HGNC Symbol%3BAcc:HGNC:998]
ENSG00000110013	34.89	33.44	35.93	30.97	28.23	32.13	0.203716119092402	5.68187086261916	0.0044252580450921	0.0682137267708462	11:124633112-124695707:-	SIAE	9;GO:0001681,molecular_function sialate O-acetylesterase activity;GO:0002682,biological_process regulation of immune system process;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	sialic acid acetylesterase [Source:HGNC Symbol%3BAcc:HGNC:18187]
ENSG00000118620	4.36	4.75	3.70	2.51	3.57	3.24	0.462471086057291	2.83714061692547	0.00442924867294788	0.0682137267708462	19:21020619-21060050:+	ZNF430	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0021762,biological_process substantia nigra development;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 430 [Source:HGNC Symbol%3BAcc:HGNC:20808]
ENSG00000134590	157.50	173.65	155.67	126.33	152.80	138.77	0.22927984849775	5.67802753170809	0.00443994544766535	0.0682937333852168	X:135032365-135033546:+	RTL8C	1;GO:0005515,molecular_function protein binding	NA	retrotransposon Gag like 8C [Source:HGNC Symbol%3BAcc:HGNC:2569]
ENSG00000198816	23.91	22.43	23.80	18.72	20.65	21.54	0.217211304046336	5.22485478241693	0.00446428596569895	0.0685831456586894	19:7515291-7521026:+	ZNF358	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0019827,biological_process stem cell population maintenance;GO:0021915,biological_process neural tube development;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 358 [Source:HGNC Symbol%3BAcc:HGNC:16838]
ENSG00000114126	16.47	17.04	15.59	19.47	18.80	19.32	-0.221753994674181	4.87316434967566	0.00450055486631541	0.0690548671885948	3:141944427-142149544:-	TFDP2	27;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0019904,molecular_function protein domain specific binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1903506,biological_process regulation of nucleic acid-templated transcription	TFDP2; transcription factor Dp-2; K09392	transcription factor Dp-2 [Source:HGNC Symbol%3BAcc:HGNC:11751]
ENSG00000165943	71.83	69.06	68.71	60.79	59.78	65.38	0.184545025614159	6.12110620727203	0.00451488450759362	0.0691292810353957	14:93182195-93184928:-	MOAP1	14;GO:0001844,biological_process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097190,biological_process apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand	NA	modulator of apoptosis 1 [Source:HGNC Symbol%3BAcc:HGNC:16658]
ENSG00000136848	2.87	2.96	3.20	3.81	3.82	3.64	-0.306011276771366	3.63399385695331	0.00451770288176975	0.0691292810353957	9:121567056-121785530:+	DAB2IP	114;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000185,biological_process activation of MAPKKK activity;GO:0001525,biological_process angiogenesis;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0005096,molecular_function GTPase activator activity;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006986,biological_process response to unfolded protein;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007252,biological_process I-kappaB phosphorylation;GO:0007257,biological_process activation of JUN kinase activity;GO:0007275,biological_process multicellular organism development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0017124,molecular_function SH3 domain binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0021814,biological_process cell motility involved in cerebral cortex radial glia guided migration;GO:0021819,biological_process layer formation in cerebral cortex;GO:0030139,cellular_component endocytic vesicle;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030948,biological_process negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0032403,molecular_function protein complex binding;GO:0032809,cellular_component neuronal cell body membrane;GO:0034144,biological_process negative regulation of toll-like receptor 4 signaling pathway;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035148,biological_process tube formation;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0035591,molecular_function signaling adaptor activity;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0036312,molecular_function phosphatidylinositol 3-kinase regulatory subunit binding;GO:0036324,biological_process vascular endothelial growth factor receptor-2 signaling pathway;GO:0038026,biological_process reelin-mediated signaling pathway;GO:0040008,biological_process regulation of growth;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043184,molecular_function vascular endothelial growth factor receptor 2 binding;GO:0043254,biological_process regulation of protein complex assembly;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043553,biological_process negative regulation of phosphatidylinositol 3-kinase activity;GO:0044257,biological_process cellular protein catabolic process;GO:0044300,cellular_component cerebellar mossy fiber;GO:0044301,cellular_component climbing fiber;GO:0045087,biological_process innate immune response;GO:0045296,molecular_function cadherin binding;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0048812,biological_process neuron projection morphogenesis;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070062,cellular_component extracellular exosome;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0070317,biological_process negative regulation of G0 to G1 transition;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071889,molecular_function 14-3-3 protein binding;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0072577,biological_process endothelial cell apoptotic process;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090129,biological_process positive regulation of synapse maturation;GO:1900006,biological_process positive regulation of dendrite development;GO:1900744,biological_process regulation of p38MAPK cascade;GO:1900747,biological_process negative regulation of vascular endothelial growth factor signaling pathway;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1903363,biological_process negative regulation of cellular protein catabolic process;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response;GO:1990032,cellular_component parallel fiber;GO:1990597,cellular_component AIP1-IRE1 complex;GO:2001224,biological_process positive regulation of neuron migration;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	DAB2 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:17294]
ENSG00000127585	0.54	0.20	0.36	0.73	0.63	1.17	-1.13691026412546	0.0707491092142194	0.00452211199554832	0.0691292810353957	16:692497-705829:-	FBXL16	5;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 16 [Source:HGNC Symbol%3BAcc:HGNC:14150]
ENSG00000169247	0.16	0.26	0.14	0.33	0.50	0.31	-1.05130318337032	0.383951307080024	0.00452805156440801	0.0691349373542394	5:148923638-149063163:-	SH3TC2	7;GO:0005886,cellular_component plasma membrane;GO:0022011,biological_process myelination in peripheral nervous system;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032287,biological_process peripheral nervous system myelin maintenance;GO:0033157,biological_process regulation of intracellular protein transport;GO:0055037,cellular_component recycling endosome;GO:1901184,biological_process regulation of ERBB signaling pathway	NA	SH3 domain and tetratricopeptide repeats 2 [Source:HGNC Symbol%3BAcc:HGNC:29427]
ENSG00000129518	49.17	44.73	50.33	57.85	56.24	53.21	-0.198366642096797	5.87606208321736	0.00453646815725847	0.0691783528698396	14:34515928-34539711:-	EAPP	5;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008284,biological_process positive regulation of cell proliferation;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter	NA	E2F associated phosphoprotein [Source:HGNC Symbol%3BAcc:HGNC:19312]
ENSG00000139168	159.15	159.86	162.69	193.68	176.38	181.68	-0.184048768834006	6.81229490230645	0.00454995140675723	0.0692988304442668	12:42312077-42326118:-	ZCRB1	11;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type and RNA binding motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29620]
ENSG00000113312	68.64	69.20	70.32	80.09	75.77	81.96	-0.180703530524744	6.26718316706277	0.00456025912814366	0.0693707065657442	5:160009112-160065543:+	TTC1	5;GO:0005515,molecular_function protein binding;GO:0005778,cellular_component peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0051082,molecular_function unfolded protein binding	NA	tetratricopeptide repeat domain 1 [Source:HGNC Symbol%3BAcc:HGNC:12391]
ENSG00000198888	3883.53	4138.81	4250.23	3699.51	3745.48	3495.02	0.177548373498862	11.8542081285573	0.00456705894413286	0.0693891097595119	MT:3306-4262:+	MT-ND1	19;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030425,cellular_component dendrite;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0033194,biological_process response to hydroperoxide;GO:0042493,biological_process response to drug;GO:0043025,cellular_component neuronal cell body;GO:0045333,biological_process cellular respiration;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]; K03878	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:7455]
ENSG00000072864	27.15	26.64	29.64	34.05	31.71	31.77	-0.210975805785671	5.30813012194444	0.00461160586725841	0.0699597303802924	16:15643266-15726353:+	NDE1	44;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007020,biological_process microtubule nucleation;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007100,biological_process mitotic centrosome separation;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007405,biological_process neuroblast proliferation;GO:0008017,molecular_function microtubule binding;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0019904,molecular_function protein domain specific binding;GO:0021987,biological_process cerebral cortex development;GO:0030154,biological_process cell differentiation;GO:0030900,biological_process forebrain development;GO:0031023,biological_process microtubule organizing center organization;GO:0031616,cellular_component spindle pole centrosome;GO:0032154,cellular_component cleavage furrow;GO:0042802,molecular_function identical protein binding;GO:0045202,cellular_component synapse;GO:0047496,biological_process vesicle transport along microtubule;GO:0051298,biological_process centrosome duplication;GO:0051301,biological_process cell division;GO:0051303,biological_process establishment of chromosome localization;GO:0051642,biological_process centrosome localization;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:2000574,biological_process regulation of microtubule motor activity	NA	nudE neurodevelopment protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17619]
ENSG00000182827	32.64	35.90	32.76	28.08	30.50	30.05	0.200735944207218	5.65065213758662	0.00461588811580275	0.0699597303802924	1:226144678-226186730:-	ACBD3	11;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034237,molecular_function protein kinase A regulatory subunit binding	NA	acyl-CoA binding domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:15453]
ENSG00000253305	1.25	1.72	1.22	0.85	1.04	0.82	0.620001153745655	1.7447184344562	0.00462218937607377	0.0699698008843947	5:141408020-141512979:+	PCDHGB6	9;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protocadherin gamma subfamily B%2C 6 [Source:HGNC Symbol%3BAcc:HGNC:8713]
ENSG00000118985	14.70	11.17	17.00	11.84	9.57	12.01	0.376397549441404	4.72630890956915	0.00464228764945332	0.0701884489557419	5:95885097-95962071:-	ELL2	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008023,cellular_component transcription elongation factor complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	elongation factor for RNA polymerase II 2 [Source:HGNC Symbol%3BAcc:HGNC:17064]
ENSG00000165507	76.07	70.92	81.47	68.28	55.81	69.54	0.251955760733627	5.49008870212373	0.00469309628831295	0.0708136727023758	10:44970980-44978810:-	C10orf10	2;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion	NA	chromosome 10 open reading frame 10 [Source:HGNC Symbol%3BAcc:HGNC:23355]
ENSG00000178980	135.02	147.69	147.99	127.52	125.32	126.16	0.194073127623234	5.66087179619796	0.00469504975703337	0.0708136727023758	19:47778571-47784686:+	SELENOW	3;GO:0005737,cellular_component cytoplasm;GO:0016209,molecular_function antioxidant activity;GO:0098869,biological_process cellular oxidant detoxification	NA	selenoprotein W [Source:HGNC Symbol%3BAcc:HGNC:10752]
ENSG00000109805	29.14	29.66	26.61	31.56	33.43	33.37	-0.193285129630286	6.54939882906949	0.00470542548625304	0.0708840370884211	4:17810901-17844862:+	NCAPG	13;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000793,cellular_component condensed chromosome;GO:0000796,cellular_component condensin complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0016020,cellular_component membrane;GO:0030261,biological_process chromosome condensation;GO:0051301,biological_process cell division	NA	non-SMC condensin I complex subunit G [Source:HGNC Symbol%3BAcc:HGNC:24304]
ENSG00000092964	27.04	26.76	27.95	24.83	22.64	24.86	0.188603562401711	5.90401621742736	0.00472038673368763	0.0710232248791086	8:26514021-26658178:+	DPYSL2	42;GO:0001975,biological_process response to amphetamine;GO:0004157,molecular_function dihydropyrimidinase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006897,biological_process endocytosis;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007420,biological_process brain development;GO:0008017,molecular_function microtubule binding;GO:0010975,biological_process regulation of neuron projection development;GO:0014049,biological_process positive regulation of glutamate secretion;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0019901,molecular_function protein kinase binding;GO:0021510,biological_process spinal cord development;GO:0021772,biological_process olfactory bulb development;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030516,biological_process regulation of axon extension;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043195,cellular_component terminal bouton;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0045664,biological_process regulation of neuron differentiation;GO:0048489,biological_process synaptic vesicle transport;GO:0070062,cellular_component extracellular exosome	DPYSL2, CRMP2; dihydropyrimidinase-like 2; K07528	dihydropyrimidinase like 2 [Source:HGNC Symbol%3BAcc:HGNC:3014]
ENSG00000147912	3.23	3.47	3.70	2.95	2.22	2.80	0.391363953357978	3.15412999810136	0.00473087854081363	0.0710903059268923	9:37510891-37576349:-	FBXO10	11;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016567,biological_process protein ubiquitination;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042981,biological_process regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification	NA	F-box protein 10 [Source:HGNC Symbol%3BAcc:HGNC:13589]
ENSG00000129226	91.01	79.40	106.41	82.10	68.52	79.75	0.278467969128161	6.52790729349454	0.0047383038123649	0.0710903059268923	17:7579466-7582113:+	CD68	10;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0071310,biological_process cellular response to organic substance	CD68; CD68 antigen; K06501	CD68 molecule [Source:HGNC Symbol%3BAcc:HGNC:1693]
ENSG00000129071	28.51	27.37	27.20	25.33	22.44	25.01	0.202871649031166	5.54514605163545	0.00474202636811946	0.0710903059268923	3:129430943-129440179:-	MBD4	17;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003696,molecular_function satellite DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008263,molecular_function pyrimidine-specific mismatch base pair DNA N-glycosylase activity;GO:0009314,biological_process response to radiation;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0032355,biological_process response to estradiol;GO:0045008,biological_process depyrimidination	MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]; K10801	methyl-CpG binding domain 4%2C DNA glycosylase [Source:HGNC Symbol%3BAcc:HGNC:6919]
ENSG00000076706	1.79	2.56	1.90	2.82	3.76	2.69	-0.572231721767068	2.36358912619593	0.00477156944790111	0.0714469138200198	11:119308528-119321521:-	MCAM	13;GO:0001525,biological_process angiogenesis;GO:0003094,biological_process glomerular filtration;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0061042,biological_process vascular wound healing	NA	melanoma cell adhesion molecule [Source:HGNC Symbol%3BAcc:HGNC:6934]
ENSG00000146281	11.55	10.23	9.90	13.57	11.48	15.38	-0.338502647700753	3.99563212378797	0.00478827677539275	0.0716106983288556	6:89146049-89165565:+	PM20D2	7;GO:0005654,cellular_component nucleoplasm;GO:0006508,biological_process proteolysis;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016805,molecular_function dipeptidase activity;GO:0032268,biological_process regulation of cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome	NA	peptidase M20 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:21408]
ENSG00000100811	58.40	60.40	56.71	67.28	66.26	66.41	-0.177822212038466	6.28399513811203	0.00481579161853388	0.0719355251033225	14:100238297-100282792:+	YY1	50;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000400,molecular_function four-way junction DNA binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006403,biological_process RNA localization;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010225,biological_process response to UV-C;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016363,cellular_component nuclear matrix;GO:0016579,biological_process protein deubiquitination;GO:0030154,biological_process cell differentiation;GO:0031011,cellular_component Ino80 complex;GO:0031519,cellular_component PcG protein complex;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0034644,biological_process cellular response to UV;GO:0034696,biological_process response to prostaglandin F;GO:0042826,molecular_function histone deacetylase binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0048593,biological_process camera-type eye morphogenesis;GO:0051276,biological_process chromosome organization;GO:0071347,biological_process cellular response to interleukin-1;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter	NA	YY1 transcription factor [Source:HGNC Symbol%3BAcc:HGNC:12856]
ENSG00000140297	37.09	40.51	36.63	32.99	35.09	31.31	0.209743228790946	5.55052454277895	0.00484527878405411	0.0722889970510381	15:59594874-59640239:+	GCNT3	19;GO:0000139,cellular_component Golgi membrane;GO:0002426,biological_process immunoglobulin production in mucosal tissue;GO:0003829,molecular_function beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0008109,molecular_function N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0047225,molecular_function acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0048729,biological_process tissue morphogenesis;GO:0050892,biological_process intestinal absorption;GO:0060993,biological_process kidney morphogenesis;GO:0070062,cellular_component extracellular exosome	GCNT3; N-acetylglucosaminyltransferase 3, mucin type [EC:2.4.1.-]; K09662	glucosaminyl (N-acetyl) transferase 3%2C mucin type [Source:HGNC Symbol%3BAcc:HGNC:4205]
ENSG00000182568	14.48	15.29	15.35	18.06	17.57	16.68	-0.202574830160686	5.35705987690126	0.00486380419518924	0.0724782730790925	3:18345386-18445588:-	SATB1	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005720,cellular_component nuclear heterochromatin;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008544,biological_process epidermis development;GO:0016032,biological_process viral process;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0042110,biological_process T cell activation;GO:0043367,biological_process CD4-positive, alpha-beta T cell differentiation;GO:0043374,biological_process CD8-positive, alpha-beta T cell differentiation;GO:0050798,biological_process activated T cell proliferation;GO:0060004,biological_process reflex;GO:0097194,biological_process execution phase of apoptosis	NA	SATB homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:10541]
ENSG00000106665	18.22	18.56	18.22	16.63	15.87	16.42	0.179614437898408	5.79039122804934	0.00488945108780681	0.0727246817483487	7:74289474-74405943:+	CLIP2	8;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005881,cellular_component cytoplasmic microtubule;GO:0008017,molecular_function microtubule binding;GO:0035371,cellular_component microtubule plus-end;GO:0051010,molecular_function microtubule plus-end binding	NA	CAP-Gly domain containing linker protein 2 [Source:HGNC Symbol%3BAcc:HGNC:2586]
ENSG00000005486	41.17	41.85	44.83	37.34	36.31	38.79	0.197102523928705	5.53160143871053	0.00489205746071628	0.0727246817483487	7:75842601-75888926:+	RHBDD2	9;GO:0000139,cellular_component Golgi membrane;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006508,biological_process proteolysis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	rhomboid domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:23082]
ENSG00000135447	1.66	3.24	2.49	1.21	1.45	1.14	0.932401188043329	0.467386984310118	0.00489850714881722	0.0727334560266365	12:54575386-54588659:-	PPP1R1A	11;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0004865,molecular_function protein serine/threonine phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007165,biological_process signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043086,biological_process negative regulation of catalytic activity	PPP1R1A; protein phosphatase 1 regulatory subunit 1A; K08050	protein phosphatase 1 regulatory inhibitor subunit 1A [Source:HGNC Symbol%3BAcc:HGNC:9286]
ENSG00000057294	0.82	1.19	0.86	1.07	1.91	1.69	-0.711660616373287	1.80561349964354	0.00490884855832501	0.0727800575730192	12:32790744-32896840:-	PKP2	47;GO:0001533,cellular_component cornified envelope;GO:0002159,biological_process desmosome assembly;GO:0003674,molecular_function molecular_function;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0007155,biological_process cell adhesion;GO:0007507,biological_process heart development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0014704,cellular_component intercalated disc;GO:0016021,cellular_component integral component of membrane;GO:0016264,biological_process gap junction assembly;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0017080,molecular_function sodium channel regulator activity;GO:0019215,molecular_function intermediate filament binding;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0030336,biological_process negative regulation of cell migration;GO:0031424,biological_process keratinization;GO:0032947,molecular_function protein complex scaffold;GO:0034334,biological_process adherens junction maintenance;GO:0044325,molecular_function ion channel binding;GO:0045110,biological_process intermediate filament bundle assembly;GO:0045294,molecular_function alpha-catenin binding;GO:0045296,molecular_function cadherin binding;GO:0048496,biological_process maintenance of organ identity;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0055088,biological_process lipid homeostasis;GO:0065009,biological_process regulation of molecular function;GO:0070268,biological_process cornification;GO:0086001,biological_process cardiac muscle cell action potential;GO:0086002,biological_process cardiac muscle cell action potential involved in contraction;GO:0086005,biological_process ventricular cardiac muscle cell action potential;GO:0086019,biological_process cell-cell signaling involved in cardiac conduction;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0086073,biological_process bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086083,molecular_function cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential;GO:2000810,biological_process regulation of bicellular tight junction assembly	PKP2; plakophilin 2; K12642	plakophilin 2 [Source:HGNC Symbol%3BAcc:HGNC:9024]
ENSG00000261587	1.71	0.77	1.88	3.23	2.66	2.27	-0.831589550566334	0.793753610340824	0.00491597415636686	0.0727800575730192	8:144352218-144354914:-	TMEM249	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 249 [Source:HGNC Symbol%3BAcc:HGNC:44155]
ENSG00000141503	24.45	24.31	24.41	21.55	22.17	21.66	0.17432547510771	6.67029832287859	0.00491923534228334	0.0727800575730192	17:4833387-4898061:+	MINK1	40;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007254,biological_process JNK cascade;GO:0007268,biological_process chemical synaptic transmission;GO:0007275,biological_process multicellular organism development;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0022407,biological_process regulation of cell-cell adhesion;GO:0030054,cellular_component cell junction;GO:0030334,biological_process regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation;GO:0048812,biological_process neuron projection morphogenesis;GO:0048813,biological_process dendrite morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	NA	misshapen like kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:17565]
ENSG00000196284	16.49	15.42	17.19	22.21	17.71	20.61	-0.286662089673855	4.35722497732711	0.00502348530991332	0.0742326860636313	6:44809316-45377953:-	SUPT3H	16;GO:0000124,cellular_component SAGA complex;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016578,biological_process histone deubiquitination;GO:0030914,cellular_component STAGA complex;GO:0033276,cellular_component transcription factor TFTC complex;GO:0043966,biological_process histone H3 acetylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity	SUPT3H, SPT3; transcription initiation protein SPT3; K11313	SPT3 homolog%2C SAGA and STAGA complex component [Source:HGNC Symbol%3BAcc:HGNC:11466]
ENSG00000168003	208.94	166.94	202.54	236.67	213.55	234.22	-0.230494763486779	8.73282335560496	0.00503186956266182	0.0742326860636313	11:62856101-62888875:+	SLC3A2	27;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005432,molecular_function calcium:sodium antiporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006810,biological_process transport;GO:0006816,biological_process calcium ion transport;GO:0006865,biological_process amino acid transport;GO:0009986,cellular_component cell surface;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015827,biological_process tryptophan transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0016324,cellular_component apical plasma membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042470,cellular_component melanosome;GO:0043330,biological_process response to exogenous dsRNA;GO:0045296,molecular_function cadherin binding;GO:0050900,biological_process leukocyte migration;GO:0060356,biological_process leucine import;GO:0070062,cellular_component extracellular exosome;GO:1902475,biological_process L-alpha-amino acid transmembrane transport	SLC3A2, MDU1, CD98; solute carrier family 3, member 2; K06519	solute carrier family 3 member 2 [Source:HGNC Symbol%3BAcc:HGNC:11026]
ENSG00000143401	67.33	66.83	63.65	70.60	79.29	78.02	-0.193237873452013	5.93294402977492	0.00503535983771671	0.0742326860636313	1:150218416-150236156:-	ANP32E	12;GO:0000812,cellular_component Swr1 complex;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006913,biological_process nucleocytoplasmic transport;GO:0016569,biological_process covalent chromatin modification;GO:0019212,molecular_function phosphatase inhibitor activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042393,molecular_function histone binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043486,biological_process histone exchange	NA	acidic nuclear phosphoprotein 32 family member E [Source:HGNC Symbol%3BAcc:HGNC:16673]
ENSG00000151466	9.34	9.56	9.80	12.42	11.39	10.69	-0.253387511820379	4.52667702551104	0.00505161036781588	0.0743133171858684	4:128864920-129093607:-	SCLT1	15;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008022,molecular_function protein C-terminus binding;GO:0017080,molecular_function sodium channel regulator activity;GO:0030276,molecular_function clathrin binding;GO:0045162,biological_process clustering of voltage-gated sodium channels;GO:0060271,biological_process cilium morphogenesis;GO:0065009,biological_process regulation of molecular function;GO:0070062,cellular_component extracellular exosome;GO:0071439,cellular_component clathrin complex;GO:0097539,cellular_component ciliary transition fiber;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	sodium channel and clathrin linker 1 [Source:HGNC Symbol%3BAcc:HGNC:26406]
ENSG00000104812	21.38	20.36	21.51	18.43	19.14	18.49	0.188174772461521	5.57281543676847	0.00505489069204294	0.0743133171858684	19:48968124-48993310:-	GYS1	16;GO:0003824,molecular_function catalytic activity;GO:0004373,molecular_function glycogen (starch) synthase activity;GO:0005515,molecular_function protein binding;GO:0005536,molecular_function glucose binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0007507,biological_process heart development;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019901,molecular_function protein kinase binding;GO:0061547,molecular_function glycogen synthase activity, transferring glucose-1-phosphate	GYS; glycogen synthase [EC:2.4.1.11]; K00693	glycogen synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:4706]
ENSG00000129757	13.12	14.76	14.83	16.57	18.13	17.69	-0.287210977266801	3.94089334031705	0.00505878941610076	0.0743133171858684	11:2883212-2885881:-	CDKN1C	33;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001501,biological_process skeletal system development;GO:0001822,biological_process kidney development;GO:0001890,biological_process placenta development;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007096,biological_process regulation of exit from mitosis;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007568,biological_process aging;GO:0030099,biological_process myeloid cell differentiation;GO:0030325,biological_process adrenal gland development;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0032403,molecular_function protein complex binding;GO:0033673,biological_process negative regulation of kinase activity;GO:0035264,biological_process multicellular organism growth;GO:0042326,biological_process negative regulation of phosphorylation;GO:0042551,biological_process neuron maturation;GO:0043010,biological_process camera-type eye development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0055123,biological_process digestive system development;GO:0060065,biological_process uterus development;GO:0060669,biological_process embryonic placenta morphogenesis;GO:0071514,biological_process genetic imprinting;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:1902746,biological_process regulation of lens fiber cell differentiation;GO:1904030,biological_process negative regulation of cyclin-dependent protein kinase activity	CDKN1C, P57, KIP2; cyclin-dependent kinase inhibitor 1C; K09993	cyclin dependent kinase inhibitor 1C [Source:HGNC Symbol%3BAcc:HGNC:1786]
ENSG00000115919	2.30	1.75	2.11	1.32	1.58	1.06	0.66936645630991	1.452365810071	0.00507594974242536	0.0744772625918748	2:142877497-143055832:+	KYNU	18;GO:0003824,molecular_function catalytic activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006569,biological_process tryptophan catabolic process;GO:0009435,biological_process NAD biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0019441,biological_process tryptophan catabolic process to kynurenine;GO:0019442,biological_process tryptophan catabolic process to acetyl-CoA;GO:0019805,biological_process quinolinate biosynthetic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030429,molecular_function kynureninase activity;GO:0034341,biological_process response to interferon-gamma;GO:0034516,biological_process response to vitamin B6;GO:0042803,molecular_function protein homodimerization activity;GO:0043420,biological_process anthranilate metabolic process;GO:0097053,biological_process L-kynurenine catabolic process	KYNU, kynU; kynureninase [EC:3.7.1.3]; K01556	kynureninase [Source:HGNC Symbol%3BAcc:HGNC:6469]
ENSG00000070081	105.47	97.51	101.96	94.45	84.22	91.08	0.189505105598273	6.93740260913316	0.00509440827357977	0.0746598463989914	11:17208152-17349974:+	NUCB2	5;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum	NA	nucleobindin 2 [Source:HGNC Symbol%3BAcc:HGNC:8044]
ENSG00000141753	5.20	3.09	3.90	2.32	2.45	2.91	0.695373771736773	1.45114766233874	0.00510542148932794	0.0747330152677213	17:40443460-40457731:+	IGFBP4	23;GO:0001501,biological_process skeletal system development;GO:0001558,biological_process regulation of cell growth;GO:0005102,molecular_function receptor binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006259,biological_process DNA metabolic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0010906,biological_process regulation of glucose metabolic process;GO:0019838,molecular_function growth factor binding;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0031995,molecular_function insulin-like growth factor II binding;GO:0040008,biological_process regulation of growth;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043567,biological_process regulation of insulin-like growth factor receptor signaling pathway;GO:0043568,biological_process positive regulation of insulin-like growth factor receptor signaling pathway;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0044342,biological_process type B pancreatic cell proliferation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	insulin like growth factor binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:5473]
ENSG00000137251	16.39	16.52	16.59	13.64	11.85	15.62	0.277210303236022	4.51447358146635	0.00514274921711121	0.0751637875815777	6:54307858-54390152:+	TINAG	14;GO:0000166,molecular_function nucleotide binding;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0030247,molecular_function polysaccharide binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	tubulointerstitial nephritis antigen [Source:HGNC Symbol%3BAcc:HGNC:14599]
ENSG00000213614	85.88	87.25	90.07	78.88	78.51	78.60	0.169217392095307	7.22230052205826	0.00514722591014343	0.0751637875815777	15:72340918-72376476:-	HEXA	19;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004563,molecular_function beta-N-acetylhexosaminidase activity;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0030214,biological_process hyaluronan catabolic process;GO:0042340,biological_process keratan sulfate catabolic process;GO:0042582,cellular_component azurophil granule;GO:0043202,cellular_component lysosomal lumen;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome;GO:0102148,molecular_function N-acetyl-beta-D-galactosaminidase activity	HEXA_B; hexosaminidase [EC:3.2.1.52]; K12373	hexosaminidase subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:4878]
ENSG00000135299	0.58	0.51	0.87	1.13	1.21	0.97	-0.723604431309308	1.21964423121013	0.00515301564746013	0.0751637875815777	6:89433169-89633834:+	ANKRD6	6;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046330,biological_process positive regulation of JNK cascade;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000096,biological_process positive regulation of Wnt signaling pathway, planar cell polarity pathway	NA	ankyrin repeat domain 6 [Source:HGNC Symbol%3BAcc:HGNC:17280]
ENSG00000106268	28.28	33.63	24.81	34.16	43.08	34.31	-0.359038329987905	4.15950014634899	0.00517155318231118	0.0753456451314891	7:2242221-2251146:+	NUDT1	32;GO:0001669,cellular_component acrosomal vesicle;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006195,biological_process purine nucleotide catabolic process;GO:0006203,biological_process dGTP catabolic process;GO:0006281,biological_process DNA repair;GO:0006979,biological_process response to oxidative stress;GO:0007568,biological_process aging;GO:0008413,molecular_function 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0008584,biological_process male gonad development;GO:0016787,molecular_function hydrolase activity;GO:0030515,molecular_function snoRNA binding;GO:0031965,cellular_component nuclear membrane;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0035539,molecular_function 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0036219,molecular_function GTP diphosphatase activity;GO:0042262,biological_process DNA protection;GO:0044713,molecular_function 2-hydroxy-adenosine triphosphate pyrophosphatase activity;GO:0044714,molecular_function 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity;GO:0046061,biological_process dATP catabolic process;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding;GO:0047693,molecular_function ATP diphosphatase activity;GO:0070062,cellular_component extracellular exosome	NA	nudix hydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:8048]
ENSG00000112473	103.29	114.89	95.04	85.51	98.72	83.99	0.234433588921747	7.23003820322349	0.00519369041617827	0.0755286535943754	6:33200444-33204439:+	SLC39A7	16;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0071577,biological_process zinc II ion transmembrane transport	NA	solute carrier family 39 member 7 [Source:HGNC Symbol%3BAcc:HGNC:4927]
ENSG00000090674	5.09	5.00	4.86	3.83	3.46	4.33	0.370114775015389	3.03349699933609	0.00519628374845699	0.0755286535943754	19:7522625-7534009:+	MCOLN1	24;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005381,molecular_function iron ion transmembrane transporter activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane;GO:0033572,biological_process transferrin transport;GO:0034755,biological_process iron ion transmembrane transport;GO:0043235,cellular_component receptor complex;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0070588,biological_process calcium ion transmembrane transport;GO:0072345,molecular_function NAADP-sensitive calcium-release channel activity;GO:0097352,biological_process autophagosome maturation	MCOLN1, TRPML1; mucolipin 1; K04992	mucolipin 1 [Source:HGNC Symbol%3BAcc:HGNC:13356]
ENSG00000157510	9.13	9.42	9.68	12.38	9.68	12.94	-0.299927212849701	4.61486429417415	0.00520934412306014	0.0756299281866029	5:149271870-149341802:+	AFAP1L1	6;GO:0002102,cellular_component podosome;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0030054,cellular_component cell junction;GO:0042995,cellular_component cell projection;GO:0071437,cellular_component invadopodium	NA	actin filament associated protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:26714]
ENSG00000129824	286.56	277.95	279.76	330.30	302.54	326.35	-0.172222919521546	7.94543012144012	0.00522899061672031	0.0757996858430829	Y:2841485-2932000:+	RPS4Y1	19;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005844,cellular_component polysome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-S4e, RPS4; small subunit ribosomal protein S4e; K02987	ribosomal protein S4%2C Y-linked 1 [Source:HGNC Symbol%3BAcc:HGNC:10425]
ENSG00000125872	28.06	36.89	24.30	36.46	40.18	35.76	-0.324459497482333	6.22249580433607	0.00523324988057053	0.0757996858430829	20:6040777-6054049:-	LRRN4	6;GO:0005887,cellular_component integral component of plasma membrane;GO:0007616,biological_process long-term memory;GO:0008542,biological_process visual learning;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	leucine rich repeat neuronal 4 [Source:HGNC Symbol%3BAcc:HGNC:16208]
ENSG00000127824	63.79	57.27	60.79	77.24	63.34	73.33	-0.221169301349481	6.55911633040378	0.0052540478831308	0.0758839462070776	2:219249710-219278170:-	TUBA4A	19;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0002576,biological_process platelet degranulation;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019899,molecular_function enzyme binding;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	TUBA; tubulin alpha; K07374	tubulin alpha 4a [Source:HGNC Symbol%3BAcc:HGNC:12407]
ENSG00000141076	29.71	26.20	29.97	34.60	30.88	34.55	-0.205194018929327	6.15750220885673	0.00525542641573389	0.0758839462070776	16:69131290-69231130:+	UTP4	13;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0030490,biological_process maturation of SSU-rRNA;GO:0034455,cellular_component t-UTP complex;GO:0042254,biological_process ribosome biogenesis	UTP4, CIRH1A; U3 small nucleolar RNA-associated protein 4; K14548	UTP4%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:1983]
ENSG00000179222	152.23	192.05	144.29	123.35	153.50	121.38	0.306341157006157	8.53162441899809	0.00525740705212976	0.0758839462070776	X:51803006-51902357:+	MAGED1	21;GO:0000785,cellular_component chromatin;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0032922,biological_process circadian regulation of gene expression;GO:0042752,biological_process regulation of circadian rhythm;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	MAGED1, NRAGE; melanoma-associated antigen D1; K12464	MAGE family member D1 [Source:HGNC Symbol%3BAcc:HGNC:6813]
ENSG00000172986	16.65	17.45	16.51	14.43	13.90	14.91	0.23472582871034	4.45134499546792	0.00527314386226902	0.0760134969692261	3:72888072-72998138:+	GXYLT2	6;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0035252,molecular_function UDP-xylosyltransferase activity	GXYLT; UDP-xylose:glucoside alpha-1,3-xylosyltransferase [EC:2.4.2.-]; K13676	glucoside xylosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:33383]
ENSG00000204592	229.76	211.86	229.23	200.84	193.49	205.26	0.174505672000224	7.83140074420996	0.00527863001590856	0.0760134969692261	6:30489466-30494205:+	HLA-E	7;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0006955,biological_process immune response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019882,biological_process antigen processing and presentation;GO:0042612,cellular_component MHC class I protein complex	MHC1; MHC class I antigen; K06751	major histocompatibility complex%2C class I%2C E [Source:HGNC Symbol%3BAcc:HGNC:4962]
ENSG00000089351	53.07	49.73	53.88	48.07	45.34	46.12	0.180275689618004	6.96820804676585	0.00529187209081331	0.0761158844302036	19:34994783-35026471:+	GRAMD1A	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	GRAM domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:29305]
ENSG00000163710	24.80	20.35	22.59	18.75	18.53	20.29	0.252227885504166	4.78479252680823	0.0053033497633472	0.0761926858940149	3:142815921-142889203:-	PCOLCE2	7;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0008201,molecular_function heparin binding;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016504,molecular_function peptidase activator activity;GO:0070062,cellular_component extracellular exosome;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	procollagen C-endopeptidase enhancer 2 [Source:HGNC Symbol%3BAcc:HGNC:8739]
ENSG00000160746	59.00	59.33	56.29	51.22	53.10	51.71	0.173617316824934	6.91143152445261	0.00531983915534777	0.0763412294050079	3:43354858-43691594:-	ANO10	11;GO:0005227,molecular_function calcium activated cation channel activity;GO:0005229,molecular_function intracellular calcium activated chloride channel activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006812,biological_process cation transport;GO:0006821,biological_process chloride transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	anoctamin 10 [Source:HGNC Symbol%3BAcc:HGNC:25519]
ENSG00000079616	39.14	41.73	36.22	45.49	48.38	42.49	-0.209906520336431	6.45798001498648	0.00534633613862156	0.0766328758530131	16:29790718-29805385:+	KIF22	27;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000776,cellular_component kinetochore;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006281,biological_process DNA repair;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007062,biological_process sister chromatid cohesion;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008017,molecular_function microtubule binding;GO:0016607,cellular_component nuclear speck;GO:0016887,molecular_function ATPase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051310,biological_process metaphase plate congression;GO:0072686,cellular_component mitotic spindle	KIF22; kinesin family member 22; K10403	kinesin family member 22 [Source:HGNC Symbol%3BAcc:HGNC:6391]
ENSG00000171033	68.77	62.87	61.33	53.53	49.23	55.51	0.298867352583978	3.7544630822212	0.0053589696601497	0.0767253637732851	8:78516138-78605267:+	PKIA	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0042308,biological_process negative regulation of protein import into nucleus;GO:0043086,biological_process negative regulation of catalytic activity;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity	PKIA; cAMP-dependent protein kinase inhibitor alpha; K15985	cAMP-dependent protein kinase inhibitor alpha [Source:HGNC Symbol%3BAcc:HGNC:9017]
ENSG00000074842	200.52	195.85	191.74	176.46	172.54	178.13	0.169637657473031	7.04443889469294	0.00537749938525587	0.0769019583746326	19:4641373-4670370:-	MYDGF	17;GO:0001525,biological_process angiogenesis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006915,biological_process apoptotic process;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome	NA	myeloid derived growth factor [Source:HGNC Symbol%3BAcc:HGNC:16948]
ENSG00000151553	10.24	10.07	9.99	7.73	9.27	8.66	0.252005157324026	4.47636460571564	0.00539356901829392	0.0770430060116024	10:114821743-114899832:+	FAM160B1	NA	NA	family with sequence similarity 160 member B1 [Source:HGNC Symbol%3BAcc:HGNC:29320]
ENSG00000174796	8.76	7.53	6.51	9.13	10.23	11.07	-0.403100627273671	3.07413825129031	0.0054494587265862	0.0777518749116258	4:75513945-75550473:+	THAP6	5;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:23189]
ENSG00000108474	15.11	15.02	17.24	12.68	12.08	13.98	0.303481603427153	3.83852876327902	0.00550789388221501	0.078495392376504	17:16217190-16351797:+	PIGL	8;GO:0000225,molecular_function N-acetylglucosaminylphosphatidylinositol deacetylase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016787,molecular_function hydrolase activity	PIGL; N-acetylglucosaminylphosphatidylinositol deacetylase [EC:3.5.1.89]; K03434	phosphatidylinositol glycan anchor biosynthesis class L [Source:HGNC Symbol%3BAcc:HGNC:8966]
ENSG00000176244	7.76	9.41	9.76	13.33	13.50	14.12	-0.599713508443544	1.65656196573414	0.00551488812328329	0.0785049383879764	10:15077522-15088776:-	ACBD7	2;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0008289,molecular_function lipid binding	NA	acyl-CoA binding domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:17715]
ENSG00000198898	190.77	200.24	185.07	157.63	180.52	170.96	0.18947080257583	7.49608182302164	0.00558593271760665	0.0792987004269358	7:116811069-116922049:+	CAPZA2	18;GO:0003779,molecular_function actin binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005903,cellular_component brush border;GO:0006461,biological_process protein complex assembly;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006928,biological_process movement of cell or subcellular component;GO:0007596,biological_process blood coagulation;GO:0008290,cellular_component F-actin capping protein complex;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030863,cellular_component cortical cytoskeleton;GO:0045087,biological_process innate immune response;GO:0051016,biological_process barbed-end actin filament capping;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome	CAPZA; capping protein (actin filament) muscle Z-line, alpha; K10364	capping actin protein of muscle Z-line alpha subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:1490]
ENSG00000197635	282.74	266.46	288.26	245.43	251.13	256.86	0.164604381008265	9.2977182362306	0.00559191108436258	0.0792987004269358	2:161992240-162074542:-	DPP4	43;GO:0001618,molecular_function virus receptor activity;GO:0001662,biological_process behavioral fear response;GO:0001666,biological_process response to hypoxia;GO:0002020,molecular_function protease binding;GO:0004177,molecular_function aminopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0007155,biological_process cell adhesion;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008239,molecular_function dipeptidyl-peptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010716,biological_process negative regulation of extracellular matrix disassembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0031258,cellular_component lamellipodium membrane;GO:0031295,biological_process T cell costimulation;GO:0033632,biological_process regulation of cell-cell adhesion mediated by integrin;GO:0035641,biological_process locomotory exploration behavior;GO:0036343,biological_process psychomotor behavior;GO:0042110,biological_process T cell activation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043542,biological_process endothelial cell migration;GO:0045121,cellular_component membrane raft;GO:0046581,cellular_component intercellular canaliculus;GO:0046718,biological_process viral entry into host cell;GO:0050796,biological_process regulation of insulin secretion;GO:0070062,cellular_component extracellular exosome;GO:0071438,cellular_component invadopodium membrane	DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5]; K01278	dipeptidyl peptidase 4 [Source:HGNC Symbol%3BAcc:HGNC:3009]
ENSG00000213079	21.38	20.32	20.31	23.23	23.86	23.52	-0.174905283330646	6.50931706268649	0.00559427033096219	0.0792987004269358	6:154733324-154834244:+	SCAF8	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016363,cellular_component nuclear matrix;GO:0043175,molecular_function RNA polymerase core enzyme binding	NA	SR-related CTD associated factor 8 [Source:HGNC Symbol%3BAcc:HGNC:20959]
ENSG00000077713	15.81	17.47	15.68	14.56	13.49	11.96	0.298818728391743	3.93149807160663	0.00559620249528686	0.0792987004269358	X:119399059-119454478:+	SLC25A43	8;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 43 [Source:HGNC Symbol%3BAcc:HGNC:30557]
ENSG00000114166	11.23	11.07	12.06	9.75	9.91	10.09	0.221863046117743	4.74533437190568	0.00561801853194654	0.0795170627560461	3:20040022-20154404:+	KAT2B	51;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000125,cellular_component PCAF complex;GO:0000776,cellular_component kinetochore;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0004468,molecular_function lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006473,biological_process protein acetylation;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007219,biological_process Notch signaling pathway;GO:0008080,molecular_function N-acetyltransferase activity;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010835,biological_process regulation of protein ADP-ribosylation;GO:0016032,biological_process viral process;GO:0016407,molecular_function acetyltransferase activity;GO:0016573,biological_process histone acetylation;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018076,biological_process N-terminal peptidyl-lysine acetylation;GO:0018393,biological_process internal peptidyl-lysine acetylation;GO:0018394,biological_process peptidyl-lysine acetylation;GO:0019901,molecular_function protein kinase binding;GO:0031672,cellular_component A band;GO:0031674,cellular_component I band;GO:0032403,molecular_function protein complex binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035948,biological_process positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter;GO:0042641,cellular_component actomyosin;GO:0042826,molecular_function histone deacetylase binding;GO:0043966,biological_process histone H3 acetylation;GO:0043970,biological_process histone H3-K9 acetylation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process	PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]; K06062	lysine acetyltransferase 2B [Source:HGNC Symbol%3BAcc:HGNC:8638]
ENSG00000118307	1.33	1.20	1.42	1.79	1.97	1.94	-0.507410286432243	2.00857320750553	0.00564085320444953	0.0797493289599454	12:25108419-25195162:-	CASC1	NA	NA	cancer susceptibility 1 [Source:HGNC Symbol%3BAcc:HGNC:29599]
ENSG00000164649	71.50	73.05	66.39	80.35	79.12	81.53	-0.181724446179145	6.68907127684256	0.00565563494861781	0.0798673454120511	7:21900899-21946084:-	CDCA7L	12;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051301,biological_process cell division	NA	cell division cycle associated 7 like [Source:HGNC Symbol%3BAcc:HGNC:30777]
ENSG00000152601	29.07	29.35	25.03	22.41	25.32	23.53	0.237266526352904	5.04113670530828	0.00571304522450756	0.0805863981497867	3:152243827-152465780:+	MBNL1	18;GO:0001069,molecular_function regulatory region RNA binding;GO:0001701,biological_process in utero embryonic development;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007399,biological_process nervous system development;GO:0008380,biological_process RNA splicing;GO:0010494,cellular_component cytoplasmic stress granule;GO:0030326,biological_process embryonic limb morphogenesis;GO:0043484,biological_process regulation of RNA splicing;GO:0045445,biological_process myoblast differentiation;GO:0046872,molecular_function metal ion binding	NA	muscleblind like splicing regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:6923]
ENSG00000132965	1.19	0.44	1.58	2.86	1.62	2.26	-0.995427436111594	0.339620065798396	0.00572856020128926	0.0806505731904668	13:30713477-30764426:+	ALOX5AP	26;GO:0002540,biological_process leukotriene production involved in inflammatory response;GO:0002675,biological_process positive regulation of acute inflammatory response;GO:0004051,molecular_function arachidonate 5-lipoxygenase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006691,biological_process leukotriene metabolic process;GO:0008047,molecular_function enzyme activator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019370,biological_process leukotriene biosynthetic process;GO:0019372,biological_process lipoxygenase pathway;GO:0019899,molecular_function enzyme binding;GO:0031965,cellular_component nuclear membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0050544,molecular_function arachidonic acid binding;GO:0055114,biological_process oxidation-reduction process;GO:0070207,biological_process protein homotrimerization;GO:0071277,biological_process cellular response to calcium ion;GO:2001300,biological_process lipoxin metabolic process	NA	arachidonate 5-lipoxygenase activating protein [Source:HGNC Symbol%3BAcc:HGNC:436]
ENSG00000182481	133.90	150.77	118.49	148.07	181.04	156.53	-0.257473157500349	7.90346325344052	0.0057403982362296	0.0806505731904668	17:68035518-68046842:+	KPNA2	21;GO:0000018,biological_process regulation of DNA recombination;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006259,biological_process DNA metabolic process;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019054,biological_process modulation by virus of host process;GO:0042826,molecular_function histone deacetylase binding;GO:0043657,cellular_component host cell;GO:0075733,biological_process intracellular transport of virus	KPNA2_7; importin subunit alpha-1/8; K15043	karyopherin subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:6395]
ENSG00000127415	17.83	16.76	17.76	14.93	15.68	15.45	0.199554458095824	5.15825615495096	0.0057430950367131	0.0806505731904668	4:986996-1004506:+	IDUA	15;GO:0003940,molecular_function L-iduronidase activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005102,molecular_function receptor binding;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0005984,biological_process disaccharide metabolic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030135,cellular_component coated vesicle;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0030209,biological_process dermatan sulfate catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0070062,cellular_component extracellular exosome	IDUA; L-iduronidase [EC:3.2.1.76]; K01217	iduronidase%2C alpha-L- [Source:HGNC Symbol%3BAcc:HGNC:5391]
ENSG00000133195	10.46	11.23	11.44	12.33	14.15	13.59	-0.264914818788977	4.2137315593223	0.00574358387983345	0.0806505731904668	17:72645948-73092712:-	SLC39A11	14;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0071577,biological_process zinc II ion transmembrane transport	NA	solute carrier family 39 member 11 [Source:HGNC Symbol%3BAcc:HGNC:14463]
ENSG00000123473	7.48	7.09	6.33	7.60	8.42	9.04	-0.251417159630071	4.91828591946125	0.00575676875570598	0.0807443735192976	1:47250138-47314147:-	STIL	24;GO:0000578,biological_process embryonic axis specification;GO:0001701,biological_process in utero embryonic development;GO:0001843,biological_process neural tube closure;GO:0001947,biological_process heart looping;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007052,biological_process mitotic spindle organization;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0008283,biological_process cell proliferation;GO:0021915,biological_process neural tube development;GO:0030900,biological_process forebrain development;GO:0030903,biological_process notochord development;GO:0033504,biological_process floor plate development;GO:0035264,biological_process multicellular organism growth;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046599,biological_process regulation of centriole replication;GO:0051298,biological_process centrosome duplication;GO:0071539,biological_process protein localization to centrosome	NA	STIL%2C centriolar assembly protein [Source:HGNC Symbol%3BAcc:HGNC:10879]
ENSG00000087586	50.27	55.81	45.39	57.70	63.79	56.84	-0.22711472911685	6.07163316676892	0.00576433755516783	0.0807592799913073	20:56369388-56392337:-	AURKA	76;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000212,biological_process meiotic spindle organization;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000278,biological_process mitotic cell cycle;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000922,cellular_component spindle pole;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007052,biological_process mitotic spindle organization;GO:0007057,biological_process spindle assembly involved in female meiosis I;GO:0007098,biological_process centrosome cycle;GO:0007100,biological_process mitotic centrosome separation;GO:0009611,biological_process response to wounding;GO:0009948,biological_process anterior/posterior axis specification;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030030,biological_process cell projection organization;GO:0030496,cellular_component midbody;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031616,cellular_component spindle pole centrosome;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0032091,biological_process negative regulation of protein binding;GO:0032133,cellular_component chromosome passenger complex;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032465,biological_process regulation of cytokinesis;GO:0035174,molecular_function histone serine kinase activity;GO:0035404,biological_process histone-serine phosphorylation;GO:0042585,cellular_component germinal vesicle;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043203,cellular_component axon hillock;GO:0045120,cellular_component pronucleus;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0046605,biological_process regulation of centrosome cycle;GO:0046777,biological_process protein autophosphorylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051642,biological_process centrosome localization;GO:0071539,biological_process protein localization to centrosome;GO:0072686,cellular_component mitotic spindle;GO:0072687,cellular_component meiotic spindle;GO:0097421,biological_process liver regeneration;GO:0097431,cellular_component mitotic spindle pole;GO:1900195,biological_process positive regulation of oocyte maturation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1990138,biological_process neuron projection extension	AURKA; aurora kinase A [EC:2.7.11.1]; K11481	aurora kinase A [Source:HGNC Symbol%3BAcc:HGNC:11393]
ENSG00000198910	7.41	8.11	6.65	5.28	7.12	5.44	0.322846905433569	4.6558026573413	0.00577438155702532	0.0807617677080479	X:153861513-153909223:-	L1CAM	26;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0031175,biological_process neuron projection development;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0044295,cellular_component axonal growth cone;GO:0045773,biological_process positive regulation of axon extension;GO:0050808,biological_process synapse organization;GO:0050900,biological_process leukocyte migration;GO:0061564,biological_process axon development	L1CAM, CD171; L1 cell adhesion molecule; K06550	L1 cell adhesion molecule [Source:HGNC Symbol%3BAcc:HGNC:6470]
ENSG00000011143	10.64	11.13	11.13	12.72	12.61	13.50	-0.230143905784135	4.57975956628515	0.00577752756986599	0.0807617677080479	17:58205436-58219605:-	MKS1	32;GO:0001843,biological_process neural tube closure;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007368,biological_process determination of left/right symmetry;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0010669,biological_process epithelial structure maintenance;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0036064,cellular_component ciliary basal body;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0048706,biological_process embryonic skeletal system development;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0060271,biological_process cilium morphogenesis;GO:0060322,biological_process head development;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0061009,biological_process common bile duct development;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1901620,biological_process regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:1905515,biological_process non-motile cilium assembly;GO:1990403,biological_process embryonic brain development;GO:2000095,biological_process regulation of Wnt signaling pathway, planar cell polarity pathway	NA	Meckel syndrome%2C type 1 [Source:HGNC Symbol%3BAcc:HGNC:7121]
ENSG00000001630	78.23	89.28	75.50	66.57	74.52	70.36	0.210538086997345	6.87738798252166	0.00581237404276117	0.0811574791819959	7:92112150-92142952:-	CYP51A1	25;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008398,molecular_function sterol 14-demethylase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016125,biological_process sterol metabolic process;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0033488,biological_process cholesterol biosynthetic process via 24,25-dihydrolanosterol;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070988,biological_process demethylation	CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]; K05917	cytochrome P450 family 51 subfamily A member 1 [Source:HGNC Symbol%3BAcc:HGNC:2649]
ENSG00000164211	46.43	47.12	47.98	40.54	44.21	37.10	0.229120632583282	4.99572024568299	0.00582693454440482	0.0811803711674377	5:111496032-111512590:-	STARD4	12;GO:0005739,cellular_component mitochondrion;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0010873,biological_process positive regulation of cholesterol esterification;GO:0010879,biological_process cholesterol transport involved in cholesterol storage;GO:0015485,molecular_function cholesterol binding;GO:0017127,molecular_function cholesterol transporter activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032367,biological_process intracellular cholesterol transport;GO:0070508,biological_process cholesterol import;GO:0070859,biological_process positive regulation of bile acid biosynthetic process	NA	StAR related lipid transfer domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:18058]
ENSG00000113282	52.29	47.59	52.89	59.64	56.57	58.75	-0.181975310606843	6.75811861519735	0.00583352552564019	0.0811803711674377	5:157785742-157859175:-	CLINT1	16;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030276,molecular_function clathrin binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding;GO:0048268,biological_process clathrin coat assembly;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	clathrin interactor 1 [Source:HGNC Symbol%3BAcc:HGNC:23186]
ENSG00000084636	0.72	0.71	0.74	1.23	0.78	1.24	-0.570873446812706	2.23045314436199	0.00583363337479694	0.0811803711674377	1:31652246-31704319:-	COL16A1	15;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005597,cellular_component collagen type XVI trimer;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007565,biological_process female pregnancy;GO:0030198,biological_process extracellular matrix organization;GO:0033622,biological_process integrin activation;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0071230,biological_process cellular response to amino acid stimulus	NA	collagen type XVI alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2193]
ENSG00000113504	8.50	5.74	7.84	10.41	7.80	10.81	-0.376303193347576	4.81635241500359	0.00584210536253409	0.0812072271726044	5:1050375-1112035:-	SLC12A7	18;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006884,biological_process cell volume homeostasis;GO:0007268,biological_process chemical synaptic transmission;GO:0015293,molecular_function symporter activity;GO:0015377,molecular_function cation:chloride symporter activity;GO:0015379,molecular_function potassium:chloride symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0022820,molecular_function potassium ion symporter activity;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	SLC12A7, KCC4; solute carrier family 12 (potassium/chloride transporter), member 7; K13627	solute carrier family 12 member 7 [Source:HGNC Symbol%3BAcc:HGNC:10915]
ENSG00000124380	52.28	51.24	48.75	57.37	58.96	61.45	-0.212705422044875	4.89972090320244	0.0058723481674635	0.0815363062670296	2:69893559-69905575:+	SNRNP27	9;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006397,biological_process mRNA processing;GO:0008150,biological_process biological_process;GO:0008380,biological_process RNA splicing	NA	small nuclear ribonucleoprotein U4/U6.U5 subunit 27 [Source:HGNC Symbol%3BAcc:HGNC:30240]
ENSG00000169189	82.94	72.99	74.11	88.78	83.32	94.83	-0.201199160610178	6.18014985907976	0.00588717716816928	0.081650871718978	16:27224990-27268794:-	NSMCE1	19;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006301,biological_process postreplication repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0030915,cellular_component Smc5-Smc6 complex;GO:0035556,biological_process intracellular signal transduction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:2001022,biological_process positive regulation of response to DNA damage stimulus	NA	NSE1 homolog%2C SMC5-SMC6 complex component [Source:HGNC Symbol%3BAcc:HGNC:29897]
ENSG00000196961	36.48	38.51	39.45	34.31	33.92	33.88	0.175787788602059	6.72739717369219	0.00593895931822522	0.082277122786975	19:49766967-49807113:+	AP2A1	38;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006895,biological_process Golgi to endosome transport;GO:0006897,biological_process endocytosis;GO:0007018,biological_process microtubule-based movement;GO:0008022,molecular_function protein C-terminus binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019901,molecular_function protein kinase binding;GO:0030117,cellular_component membrane coat;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030130,cellular_component clathrin coat of trans-Golgi network vesicle;GO:0030131,cellular_component clathrin adaptor complex;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0032403,molecular_function protein complex binding;GO:0032433,cellular_component filopodium tip;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035615,molecular_function clathrin adaptor activity;GO:0036020,cellular_component endolysosome membrane;GO:0043234,cellular_component protein complex;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis;GO:1900126,biological_process negative regulation of hyaluronan biosynthetic process	AP2A; AP-2 complex subunit alpha; K11824	adaptor related protein complex 2 alpha 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:561]
ENSG00000130475	0.91	0.95	0.59	1.26	1.06	1.57	-0.673498307103871	1.60904696528719	0.00595752033625255	0.0824422518772607	19:17747717-17788568:+	FCHO1	11;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006897,biological_process endocytosis;GO:0016020,cellular_component membrane;GO:0035612,molecular_function AP-2 adaptor complex binding;GO:0048268,biological_process clathrin coat assembly;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis	NA	FCH domain only 1 [Source:HGNC Symbol%3BAcc:HGNC:29002]
ENSG00000206503	2446.78	2412.41	2581.00	2232.77	2202.02	2287.46	0.158258014687591	11.360597580333	0.00597052073821167	0.0824448554455345	6:29941259-29945884:+	HLA-A	31;GO:0000139,cellular_component Golgi membrane;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0019882,biological_process antigen processing and presentation;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030881,molecular_function beta-2-microglobulin binding;GO:0031901,cellular_component early endosome membrane;GO:0042270,biological_process protection from natural killer cell mediated cytotoxicity;GO:0042605,molecular_function peptide antigen binding;GO:0042612,cellular_component MHC class I protein complex;GO:0046977,molecular_function TAP binding;GO:0050776,biological_process regulation of immune response;GO:0055038,cellular_component recycling endosome membrane;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane	MHC1; MHC class I antigen; K06751	major histocompatibility complex%2C class I%2C A [Source:HGNC Symbol%3BAcc:HGNC:4931]
ENSG00000162236	27.63	27.06	25.06	24.94	22.65	19.05	0.27136968617657	4.90294732818975	0.00597653804368542	0.0824448554455345	11:62806896-62832088:-	STX5	29;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006906,biological_process vesicle fusion;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031201,cellular_component SNARE complex;GO:0031982,cellular_component vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034498,biological_process early endosome to Golgi transport;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0045296,molecular_function cadherin binding;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0047485,molecular_function protein N-terminus binding;GO:0048208,biological_process COPII vesicle coating;GO:0048278,biological_process vesicle docking;GO:0048280,biological_process vesicle fusion with Golgi apparatus;GO:0090166,biological_process Golgi disassembly;GO:1903358,biological_process regulation of Golgi organization	STX5; syntaxin 5; K08490	syntaxin 5 [Source:HGNC Symbol%3BAcc:HGNC:11440]
ENSG00000162777	0.53	1.10	0.75	0.41	0.36	0.29	1.13474208770653	-0.0531894140600134	0.00598212019923897	0.0824448554455345	1:111187173-111204535:-	DENND2D	7;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity	NA	DENN domain containing 2D [Source:HGNC Symbol%3BAcc:HGNC:26192]
ENSG00000100558	24.34	22.74	23.28	28.78	25.14	29.95	-0.240172147119102	4.77890346087668	0.00598427573966217	0.0824448554455345	14:67386982-67412200:-	PLEK2	12;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0031258,cellular_component lamellipodium membrane;GO:0031346,biological_process positive regulation of cell projection organization;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	pleckstrin 2 [Source:HGNC Symbol%3BAcc:HGNC:19238]
ENSG00000204947	1.58	1.23	1.24	0.61	0.98	1.00	0.66084196926268	1.44543581074171	0.00599436499747632	0.082492297908729	7:149102783-149126346:-	ZNF425	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 425 [Source:HGNC Symbol%3BAcc:HGNC:20690]
ENSG00000166278	0.75	0.82	0.98	0.26	0.62	0.55	0.831839277276248	0.877826867441959	0.00603289369540151	0.0829305752392237	6:31897784-31945672:+	C2	17;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0007584,biological_process response to nutrient;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030449,biological_process regulation of complement activation;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:2000427,biological_process positive regulation of apoptotic cell clearance	C2; complement component 2 [EC:3.4.21.43]; K01332	complement C2 [Source:HGNC Symbol%3BAcc:HGNC:1248]
ENSG00000241973	18.09	18.74	17.46	14.54	17.43	15.51	0.204655053958798	6.74662813653886	0.00604732058419197	0.0830369362959899	22:20707690-20859417:-	PI4KA	25;GO:0000166,molecular_function nucleotide binding;GO:0004430,molecular_function 1-phosphatidylinositol 4-kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019034,cellular_component viral replication complex;GO:0030036,biological_process actin cytoskeleton organization;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0039694,biological_process viral RNA genome replication;GO:0044803,biological_process multi-organism membrane organization;GO:0045296,molecular_function cadherin binding;GO:0046786,biological_process viral replication complex formation and maintenance;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0070062,cellular_component extracellular exosome	PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]; K00888	phosphatidylinositol 4-kinase alpha [Source:HGNC Symbol%3BAcc:HGNC:8983]
ENSG00000125266	4.60	5.17	5.30	3.37	3.87	3.59	0.482435122412873	2.15001095577923	0.0060815000600877	0.0833205453487112	13:106489730-106535114:-	EFNB2	34;GO:0001525,biological_process angiogenesis;GO:0001618,molecular_function virus receptor activity;GO:0001945,biological_process lymph vessel development;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009887,biological_process organ morphogenesis;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030154,biological_process cell differentiation;GO:0031295,biological_process T cell costimulation;GO:0046718,biological_process viral entry into host cell;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048514,biological_process blood vessel morphogenesis;GO:0048845,biological_process venous blood vessel morphogenesis;GO:0050920,biological_process regulation of chemotaxis;GO:0072178,biological_process nephric duct morphogenesis;GO:1901216,biological_process positive regulation of neuron death;GO:1903849,biological_process positive regulation of aorta morphogenesis;GO:2000727,biological_process positive regulation of cardiac muscle cell differentiation	EFNB; ephrin-B; K05463	ephrin B2 [Source:HGNC Symbol%3BAcc:HGNC:3227]
ENSG00000071553	79.20	80.33	83.69	72.02	75.49	69.03	0.179752170251287	6.87015060446426	0.00608493590203231	0.0833205453487112	X:154428631-154436516:+	ATP6AP1	31;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016469,cellular_component proton-transporting two-sector ATPase complex;GO:0017137,molecular_function Rab GTPase binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0033180,cellular_component proton-transporting V-type ATPase, V1 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0036295,biological_process cellular response to increased oxygen levels;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045780,biological_process positive regulation of bone resorption;GO:0045851,biological_process pH reduction;GO:0045921,biological_process positive regulation of exocytosis;GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0051656,biological_process establishment of organelle localization;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:2001206,biological_process positive regulation of osteoclast development	ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit; K03662	ATPase H+ transporting accessory protein 1 [Source:HGNC Symbol%3BAcc:HGNC:868]
ENSG00000213782	49.83	50.90	49.50	58.25	56.06	56.25	-0.172354416069142	6.19363190708462	0.00608811203023291	0.0833205453487112	12:12813315-12829981:+	DDX47	19;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008380,biological_process RNA splicing;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity	NA	DEAD-box helicase 47 [Source:HGNC Symbol%3BAcc:HGNC:18682]
ENSG00000113739	127.00	107.37	122.37	145.12	125.51	149.47	-0.222373211230658	6.88007303597014	0.00610513424112447	0.0834614882544912	5:173314712-173329503:-	STC2	26;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006979,biological_process response to oxidative stress;GO:0007566,biological_process embryo implantation;GO:0010629,biological_process negative regulation of gene expression;GO:0019899,molecular_function enzyme binding;GO:0020037,molecular_function heme binding;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0033280,biological_process response to vitamin D;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0042803,molecular_function protein homodimerization activity;GO:0043434,biological_process response to peptide hormone;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046697,biological_process decidualization;GO:0046885,biological_process regulation of hormone biosynthetic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055074,biological_process calcium ion homeostasis;GO:0071456,biological_process cellular response to hypoxia;GO:2001256,biological_process regulation of store-operated calcium entry	NA	stanniocalcin 2 [Source:HGNC Symbol%3BAcc:HGNC:11374]
ENSG00000205336	103.02	83.56	106.04	116.71	113.23	114.61	-0.222585818367731	7.82146871480386	0.00613615573968597	0.083764781295336	16:57610651-57665580:+	ADGRG1	38;GO:0001525,biological_process angiogenesis;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007266,biological_process Rho protein signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0008201,molecular_function heparin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010573,biological_process vascular endothelial growth factor production;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0021796,biological_process cerebral cortex regionalization;GO:0021801,biological_process cerebral cortex radial glia guided migration;GO:0021819,biological_process layer formation in cerebral cortex;GO:0030154,biological_process cell differentiation;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0045121,cellular_component membrane raft;GO:0045785,biological_process positive regulation of cell adhesion;GO:0050840,molecular_function extracellular matrix binding;GO:0070062,cellular_component extracellular exosome;GO:0070528,biological_process protein kinase C signaling;GO:0072520,biological_process seminiferous tubule development;GO:0097451,cellular_component glial limiting end-foot;GO:2000179,biological_process positive regulation of neural precursor cell proliferation;GO:2001223,biological_process negative regulation of neuron migration	NA	adhesion G protein-coupled receptor G1 [Source:HGNC Symbol%3BAcc:HGNC:4512]
ENSG00000106355	123.25	122.66	115.82	143.66	130.35	140.79	-0.18686206293243	5.88510297503584	0.00614081615876547	0.083764781295336	7:32485331-32495283:-	LSM5	15;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005688,cellular_component U6 snRNP;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:1990726,cellular_component Lsm1-7-Pat1 complex	LSM5; U6 snRNA-associated Sm-like protein LSm5; K12624	LSM5 homolog%2C U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol%3BAcc:HGNC:17162]
ENSG00000112081	265.96	299.87	258.95	319.39	316.60	311.88	-0.190485839755348	7.47618155965827	0.00615373336484883	0.0838488389219193	6:36594352-36605600:+	SRSF3	18;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0051028,biological_process mRNA transport;GO:1990825,molecular_function sequence-specific mRNA binding	SFRS3; splicing factor, arginine/serine-rich 3; K12892	serine and arginine rich splicing factor 3 [Source:HGNC Symbol%3BAcc:HGNC:10785]
ENSG00000161791	9.70	8.18	10.00	12.25	9.78	12.05	-0.273506947863191	5.06046218216015	0.00616681862769624	0.0838745823109489	12:49636498-49708165:-	FMNL3	16;GO:0001525,biological_process angiogenesis;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007275,biological_process multicellular organism development;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016043,biological_process cellular component organization;GO:0016477,biological_process cell migration;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0032794,molecular_function GTPase activating protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	formin like 3 [Source:HGNC Symbol%3BAcc:HGNC:23698]
ENSG00000128656	2.75	2.34	4.28	4.45	4.02	5.65	-0.566582649569347	2.80100305699744	0.00616913668330752	0.0838745823109489	2:174799362-175005369:-	CHN1	18;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008045,biological_process motor neuron axon guidance;GO:0009967,biological_process positive regulation of signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050770,biological_process regulation of axonogenesis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	chimerin 1 [Source:HGNC Symbol%3BAcc:HGNC:1943]
ENSG00000158769	37.87	41.76	42.42	48.75	45.32	47.74	-0.207253608253073	5.30877182133845	0.00617763960280086	0.0838982936428524	1:160995210-161021348:-	F11R	34;GO:0001618,molecular_function virus receptor activity;GO:0001817,biological_process regulation of cytokine production;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0009314,biological_process response to radiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030165,molecular_function PDZ domain binding;GO:0030198,biological_process extracellular matrix organization;GO:0030855,biological_process epithelial cell differentiation;GO:0031032,biological_process actomyosin structure organization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034260,biological_process negative regulation of GTPase activity;GO:0036057,cellular_component slit diaphragm;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0045777,biological_process positive regulation of blood pressure;GO:0046718,biological_process viral entry into host cell;GO:0050892,biological_process intestinal absorption;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:0090559,biological_process regulation of membrane permeability;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	F11R, JAM1, CD321; junctional adhesion molecule 1; K06089	F11 receptor [Source:HGNC Symbol%3BAcc:HGNC:14685]
ENSG00000213983	37.49	36.93	44.35	33.22	34.14	35.98	0.213755942464901	6.4497116589117	0.00618453951626661	0.0839002065742267	14:23559564-23568070:-	AP1G2	19;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030121,cellular_component AP-1 adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030133,cellular_component transport vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle	AP1G1; AP-1 complex subunit gamma-1; K12391	adaptor related protein complex 1 gamma 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:556]
ENSG00000072422	9.98	11.12	13.08	8.07	9.99	9.63	0.315492262992201	4.43683696305364	0.00623242066824993	0.0844574647980201	10:60869437-61001440:-	RHOBTB1	8;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	RHOBTB1_2; Rho-related BTB domain-containing protein 1/2; K07868	Rho related BTB domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18738]
ENSG00000162174	2.33	2.86	2.43	3.07	4.92	3.79	-0.626753763797193	1.76313156170441	0.00626937868002197	0.0848656461887815	11:62337447-62393412:+	ASRGL1	10;GO:0004067,molecular_function asparaginase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008798,molecular_function beta-aspartyl-peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0033345,biological_process asparagine catabolic process via L-aspartate	ASRGL1, iaaA; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5]; K13051	asparaginase like 1 [Source:HGNC Symbol%3BAcc:HGNC:16448]
ENSG00000128567	3.37	3.84	3.25	4.88	4.72	4.21	-0.397376641702404	2.82927055308921	0.00628055758780382	0.0849243587553473	7:131500261-131558217:-	PODXL	32;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005902,cellular_component microvillus;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0022407,biological_process regulation of cell-cell adhesion;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0030335,biological_process positive regulation of cell migration;GO:0031528,cellular_component microvillus membrane;GO:0032534,biological_process regulation of microvillus assembly;GO:0033634,biological_process positive regulation of cell-cell adhesion mediated by integrin;GO:0036057,cellular_component slit diaphragm;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044297,cellular_component cell body;GO:0045121,cellular_component membrane raft;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0072015,biological_process glomerular visceral epithelial cell development;GO:0072175,biological_process epithelial tube formation	NA	podocalyxin like [Source:HGNC Symbol%3BAcc:HGNC:9171]
ENSG00000176399	12.99	11.76	13.19	11.44	9.78	10.56	0.272329703010092	4.14849044691242	0.00629499738354287	0.085026988598387	9:22446840-22455740:+	DMRTA1	10;GO:0001541,biological_process ovarian follicle development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042803,molecular_function protein homodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:0060179,biological_process male mating behavior	NA	DMRT like family A1 [Source:HGNC Symbol%3BAcc:HGNC:13826]
ENSG00000113657	94.03	83.50	93.95	110.61	93.80	114.54	-0.219890607832169	7.68746036606355	0.00630415387659153	0.0850581109457941	5:147390810-147510056:-	DPYSL3	27;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010975,biological_process regulation of neuron projection development;GO:0010976,biological_process positive regulation of neuron projection development;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0017124,molecular_function SH3 domain binding;GO:0030027,cellular_component lamellipodium;GO:0030334,biological_process regulation of cell migration;GO:0030336,biological_process negative regulation of cell migration;GO:0030426,cellular_component growth cone;GO:0031005,molecular_function filamin binding;GO:0031941,cellular_component filamentous actin;GO:0035374,molecular_function chondroitin sulfate binding;GO:0042995,cellular_component cell projection;GO:0044297,cellular_component cell body;GO:0048666,biological_process neuron development;GO:0048678,biological_process response to axon injury;GO:0051017,biological_process actin filament bundle assembly;GO:0051260,biological_process protein homooligomerization;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051764,biological_process actin crosslink formation;GO:0070382,cellular_component exocytic vesicle;GO:0071345,biological_process cellular response to cytokine stimulus	NA	dihydropyrimidinase like 3 [Source:HGNC Symbol%3BAcc:HGNC:3015]
ENSG00000130038	0.95	1.13	0.87	1.39	1.50	1.57	-0.601153839495765	1.62756535671587	0.0063153076878991	0.0851160850487422	12:3606632-3764819:-	CRACR2A	16;GO:0002115,biological_process store-operated calcium entry;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0016020,cellular_component membrane;GO:0032237,biological_process activation of store-operated calcium channel activity;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0051928,biological_process positive regulation of calcium ion transport	NA	calcium release activated channel regulator 2A [Source:HGNC Symbol%3BAcc:HGNC:28657]
ENSG00000198876	25.82	24.88	26.64	29.94	28.54	30.88	-0.194945115493147	5.288151066789	0.00632595365218141	0.0851670961871235	9:34086386-34127399:-	DCAF12	6;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0016567,biological_process protein ubiquitination;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 12 [Source:HGNC Symbol%3BAcc:HGNC:19911]
ENSG00000166451	25.16	28.40	23.78	30.07	32.42	28.92	-0.23491062470006	5.12411740384412	0.00634021266145992	0.0852665869628408	16:81006497-81033114:+	CENPN	12;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0034508,biological_process centromere complex assembly	NA	centromere protein N [Source:HGNC Symbol%3BAcc:HGNC:30873]
ENSG00000175455	53.17	52.69	51.88	45.04	49.39	46.72	0.172076405944605	7.20730920544599	0.00638562834040892	0.0857844205514026	3:123897304-123961408:-	CCDC14	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0021762,biological_process substantia nigra development;GO:0034451,cellular_component centriolar satellite;GO:0071539,biological_process protein localization to centrosome	NA	coiled-coil domain containing 14 [Source:HGNC Symbol%3BAcc:HGNC:25766]
ENSG00000116260	143.58	140.22	146.09	131.82	123.20	131.97	0.163648513512484	8.25884400562538	0.00641089502326821	0.0860307458635982	1:180154833-180204030:+	QSOX1	26;GO:0000139,cellular_component Golgi membrane;GO:0002576,biological_process platelet degranulation;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016491,molecular_function oxidoreductase activity;GO:0016971,molecular_function flavin-linked sulfhydryl oxidase activity;GO:0016972,molecular_function thiol oxidase activity;GO:0030173,cellular_component integral component of Golgi membrane;GO:0031093,cellular_component platelet alpha granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045171,cellular_component intercellular bridge;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen	NA	quiescin sulfhydryl oxidase 1 [Source:HGNC Symbol%3BAcc:HGNC:9756]
ENSG00000198373	14.02	13.50	14.11	15.89	15.87	16.06	-0.186255730738758	5.29533993892989	0.00645645864203102	0.0865486189238997	16:69762305-69941741:+	WWP2	34;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008134,molecular_function transcription factor binding;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0032410,biological_process negative regulation of transporter activity;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046718,biological_process viral entry into host cell;GO:0051224,biological_process negative regulation of protein transport;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0070534,biological_process protein K63-linked ubiquitination;GO:1901016,biological_process regulation of potassium ion transmembrane transporter activity	WWP2, AIP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [EC:2.3.2.26]; K05630	WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:16804]
ENSG00000164683	6.24	3.40	5.31	6.99	6.39	8.78	-0.536768146229281	2.66615925344324	0.00646701720100172	0.0865966391758731	8:79764009-79767863:-	HEY1	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0000988,molecular_function transcription factor activity, protein binding;GO:0001525,biological_process angiogenesis;GO:0003184,biological_process pulmonary valve morphogenesis;GO:0003190,biological_process atrioventricular valve formation;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003208,biological_process cardiac ventricle morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0035912,biological_process dorsal aorta morphogenesis;GO:0035939,molecular_function microsatellite binding;GO:0036304,biological_process umbilical cord morphogenesis;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0060347,biological_process heart trabecula formation;GO:0060411,biological_process cardiac septum morphogenesis;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0060842,biological_process arterial endothelial cell differentiation;GO:0061314,biological_process Notch signaling involved in heart development;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding;GO:2000820,biological_process negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation;GO:2001212,biological_process regulation of vasculogenesis	HEY; hairy and enhancer of split related with YRPW motif; K09091	hes related family bHLH transcription factor with YRPW motif 1 [Source:HGNC Symbol%3BAcc:HGNC:4880]
ENSG00000104976	29.11	27.04	27.99	31.61	32.09	33.98	-0.200955385527808	5.06766051645898	0.00648093205605674	0.0866894500127504	19:7920315-7923250:+	SNAPC2	11;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0009301,biological_process snRNA transcription;GO:0016604,cellular_component nuclear body;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	small nuclear RNA activating complex polypeptide 2 [Source:HGNC Symbol%3BAcc:HGNC:11135]
ENSG00000186577	18.87	18.79	15.34	13.34	15.17	12.88	0.365738692108528	3.24298084252083	0.00650173610388121	0.086874112225487	6:34246379-34249470:-	SMIM29	3;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 29 [Source:HGNC Symbol%3BAcc:HGNC:1340]
ENSG00000188211	1.24	1.05	1.24	2.14	1.95	1.70	-0.681548644466129	1.19616393143288	0.0065500678049616	0.0874257974870843	11:17351725-17377341:+	NCR3LG1	7;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019028,cellular_component viral capsid;GO:0050776,biological_process regulation of immune response	NA	natural killer cell cytotoxicity receptor 3 ligand 1 [Source:HGNC Symbol%3BAcc:HGNC:42400]
ENSG00000103257	135.31	122.77	134.91	157.32	143.76	148.13	-0.180208670490928	7.74050229741454	0.00658832182486706	0.087841932128974	16:87830022-87869488:-	SLC7A5	25;GO:0003333,biological_process amino acid transmembrane transport;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015179,molecular_function L-amino acid transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015804,biological_process neutral amino acid transport;GO:0015807,biological_process L-amino acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030154,biological_process cell differentiation;GO:0042605,molecular_function peptide antigen binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:1902475,biological_process L-alpha-amino acid transmembrane transport	SLC7A5, LAT1; solute carrier family 7 (L-type amino acid transporter), member 5; K13780	solute carrier family 7 member 5 [Source:HGNC Symbol%3BAcc:HGNC:11063]
ENSG00000139131	13.52	13.89	12.04	15.96	16.01	15.18	-0.249019265995765	4.37995234002402	0.00659743572463538	0.0878690661479602	12:32727489-32755902:-	YARS2	20;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004831,molecular_function tyrosine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006437,biological_process tyrosyl-tRNA aminoacylation;GO:0016604,cellular_component nuclear body;GO:0016874,molecular_function ligase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043039,biological_process tRNA aminoacylation;GO:0070184,biological_process mitochondrial tyrosyl-tRNA aminoacylation;GO:0072545,molecular_function tyrosine binding	YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]; K01866	tyrosyl-tRNA synthetase 2 [Source:HGNC Symbol%3BAcc:HGNC:24249]
ENSG00000176697	19.60	18.74	15.87	15.12	14.42	15.30	0.282634444770412	4.08414104403637	0.00662062891454173	0.0880834584310895	11:27654892-27722058:-	BDNF	22;GO:0005102,molecular_function receptor binding;GO:0005169,molecular_function neurotrophin TRKB receptor binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007416,biological_process synapse assembly;GO:0008083,molecular_function growth factor activity;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0016607,cellular_component nuclear speck;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031547,biological_process brain-derived neurotrophic factor receptor signaling pathway;GO:0031550,biological_process positive regulation of brain-derived neurotrophic factor receptor signaling pathway;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048668,biological_process collateral sprouting;GO:0048672,biological_process positive regulation of collateral sprouting;GO:0051965,biological_process positive regulation of synapse assembly;GO:1900122,biological_process positive regulation of receptor binding;GO:2000008,biological_process regulation of protein localization to cell surface	BDNF; brain-derived neurotrophic factor; K04355	brain derived neurotrophic factor [Source:HGNC Symbol%3BAcc:HGNC:1033]
ENSG00000162433	80.13	83.99	83.61	91.66	95.00	94.91	-0.174366810635598	5.88804611873546	0.00663590070002664	0.0881690751599392	1:65147548-65232145:+	AK4	27;GO:0000166,molecular_function nucleotide binding;GO:0001889,biological_process liver development;GO:0004017,molecular_function adenylate kinase activity;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0007420,biological_process brain development;GO:0009142,biological_process nucleoside triphosphate biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016776,molecular_function phosphotransferase activity, phosphate group as acceptor;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0042493,biological_process response to drug;GO:0046033,biological_process AMP metabolic process;GO:0046034,biological_process ATP metabolic process;GO:0046039,biological_process GTP metabolic process;GO:0046899,molecular_function nucleoside triphosphate adenylate kinase activity;GO:0046939,biological_process nucleotide phosphorylation;GO:0046940,biological_process nucleoside monophosphate phosphorylation;GO:0050145,molecular_function nucleoside phosphate kinase activity;GO:0070062,cellular_component extracellular exosome	adk, AK; adenylate kinase [EC:2.7.4.3]; K00939	adenylate kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:363]
ENSG00000138430	118.23	111.40	118.00	129.10	131.98	132.01	-0.164537559651369	7.2783545504742	0.00664183135884959	0.0881690751599392	2:174072446-174248698:-	OLA1	21;GO:0000166,molecular_function nucleotide binding;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0031093,cellular_component platelet alpha granule lumen;GO:0043022,molecular_function ribosome binding;GO:0043023,molecular_function ribosomal large subunit binding;GO:0045296,molecular_function cadherin binding;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	Obg like ATPase 1 [Source:HGNC Symbol%3BAcc:HGNC:28833]
ENSG00000177628	57.80	63.59	64.45	54.57	57.87	50.33	0.20239363272269	6.54792654683062	0.00664837302422485	0.0881690751599392	1:155234451-155244699:-	GBA	48;GO:0004348,molecular_function glucosylceramidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006680,biological_process glucosylceramide catabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0009267,biological_process cellular response to starvation;GO:0009268,biological_process response to pH;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0023021,biological_process termination of signal transduction;GO:0032268,biological_process regulation of cellular protein metabolic process;GO:0032269,biological_process negative regulation of cellular protein metabolic process;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032463,biological_process negative regulation of protein homooligomerization;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0033561,biological_process regulation of water loss via skin;GO:0033574,biological_process response to testosterone;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0043202,cellular_component lysosomal lumen;GO:0043243,biological_process positive regulation of protein complex disassembly;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043589,biological_process skin morphogenesis;GO:0043627,biological_process response to estrogen;GO:0046512,biological_process sphingosine biosynthetic process;GO:0046513,biological_process ceramide biosynthetic process;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051246,biological_process regulation of protein metabolic process;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071548,biological_process response to dexamethasone;GO:0097066,biological_process response to thyroid hormone;GO:1901215,biological_process negative regulation of neuron death;GO:1901805,biological_process beta-glucoside catabolic process;GO:1903052,biological_process positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903061,biological_process positive regulation of protein lipidation;GO:1904457,biological_process positive regulation of neuronal action potential;GO:1904925,biological_process positive regulation of mitophagy in response to mitochondrial depolarization;GO:1905037,biological_process autophagosome organization;GO:1905165,biological_process regulation of lysosomal protein catabolic process	GBA, srfJ; glucosylceramidase [EC:3.2.1.45]; K01201	glucosylceramidase beta [Source:HGNC Symbol%3BAcc:HGNC:4177]
ENSG00000197119	26.02	22.41	25.80	20.80	21.69	21.60	0.230136345683918	4.82856850118237	0.00666246597869246	0.0882616757668191	14:100291110-100306547:-	SLC25A29	22;GO:0005289,molecular_function high-affinity arginine transmembrane transporter activity;GO:0005292,molecular_function high-affinity lysine transmembrane transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0006844,biological_process acyl carnitine transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015174,molecular_function basic amino acid transmembrane transporter activity;GO:0015227,molecular_function acyl carnitine transmembrane transporter activity;GO:0015822,biological_process ornithine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0089709,biological_process L-histidine transmembrane transport;GO:1902616,biological_process acyl carnitine transmembrane transport;GO:1903400,biological_process L-arginine transmembrane transport;GO:1903401,biological_process L-lysine transmembrane transport;GO:1903826,biological_process arginine transmembrane transport;GO:1990575,biological_process mitochondrial L-ornithine transmembrane transport;GO:1990822,biological_process basic amino acid transmembrane transport	SLC25A20_29, CACT, CACL, CRC1; solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter), member 20/29; K15109	solute carrier family 25 member 29 [Source:HGNC Symbol%3BAcc:HGNC:20116]
ENSG00000151240	13.72	13.58	14.49	12.59	12.40	12.38	0.174298005867682	6.05875383032475	0.00668230566363901	0.0884301281479222	10:274189-689668:-	DIP2C	5;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process	NA	disco interacting protein 2 homolog C [Source:HGNC Symbol%3BAcc:HGNC:29150]
ENSG00000071626	95.00	95.57	95.73	107.12	106.83	109.16	-0.162939440062128	7.05536023413108	0.00673966126912683	0.0890941590347937	19:1407568-1435687:+	DAZAP1	13;GO:0001893,biological_process maternal placenta development;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008283,biological_process cell proliferation;GO:0030154,biological_process cell differentiation;GO:0035613,molecular_function RNA stem-loop binding;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome	MSI; RNA-binding protein Musashi; K14411	DAZ associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2683]
ENSG00000012822	26.89	25.69	26.19	22.20	23.21	24.64	0.181806391388131	5.77861911978672	0.00675337963468984	0.0891805334100054	12:53708516-53727745:-	CALCOCO1	24;GO:0000790,cellular_component nuclear chromatin;GO:0001047,molecular_function core promoter binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0008013,molecular_function beta-catenin binding;GO:0008022,molecular_function protein C-terminus binding;GO:0010628,biological_process positive regulation of gene expression;GO:0016055,biological_process Wnt signaling pathway;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070016,molecular_function armadillo repeat domain binding	NA	calcium binding and coiled-coil domain 1 [Source:HGNC Symbol%3BAcc:HGNC:29306]
ENSG00000124155	94.01	93.04	101.89	86.81	85.41	86.84	0.169746314734905	7.6501423569421	0.00677709248121706	0.0893334697055607	20:45416066-45456934:+	PIGT	14;GO:0003923,molecular_function GPI-anchor transamidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016255,biological_process attachment of GPI anchor to protein;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030182,biological_process neuron differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042765,cellular_component GPI-anchor transamidase complex;GO:0051402,biological_process neuron apoptotic process	PIGT; GPI-anchor transamidase subunit T; K05292	phosphatidylinositol glycan anchor biosynthesis class T [Source:HGNC Symbol%3BAcc:HGNC:14938]
ENSG00000146263	4.63	4.83	3.96	5.57	5.01	5.81	-0.283556210572681	4.22855361080288	0.00677950499087219	0.0893334697055607	6:97142160-97283217:-	MMS22L	11;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0031297,biological_process replication fork processing;GO:0035101,cellular_component FACT complex;GO:0042555,cellular_component MCM complex;GO:0043596,cellular_component nuclear replication fork	NA	MMS22 like%2C DNA repair protein [Source:HGNC Symbol%3BAcc:HGNC:21475]
ENSG00000106348	65.51	64.79	62.81	55.12	57.00	60.47	0.173401998962666	6.80786263898164	0.00678655135199741	0.0893334697055607	7:128392276-128410252:-	IMPDH1	22;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0003938,molecular_function IMP dehydrogenase activity;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006177,biological_process GMP biosynthetic process;GO:0006183,biological_process GTP biosynthetic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0034774,cellular_component secretory granule lumen;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046651,biological_process lymphocyte proliferation;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:1904813,cellular_component ficolin-1-rich granule lumen	IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]; K00088	inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol%3BAcc:HGNC:6052]
ENSG00000197128	1.32	1.21	1.56	2.22	2.02	2.00	-0.581068868185254	1.59689134755573	0.00684179210090157	0.0899419891606506	19:57466662-57477570:-	ZNF772	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 772 [Source:HGNC Symbol%3BAcc:HGNC:33106]
ENSG00000174428	13.18	10.83	11.16	9.42	10.36	10.36	0.238711884485514	5.12062560876566	0.00684727138941551	0.0899419891606506	7:75092572-75149817:+	GTF2IRD2B	10;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development	NA	GTF2I repeat domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:33125]
ENSG00000106105	313.14	283.08	310.91	348.19	330.25	350.84	-0.170218421546759	9.50074530125586	0.00686126156547669	0.0899703376175152	7:30594680-30634033:+	GARS	22;GO:0000166,molecular_function nucleotide binding;GO:0004081,molecular_function bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004820,molecular_function glycine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006426,biological_process glycyl-tRNA aminoacylation;GO:0015966,biological_process diadenosine tetraphosphate biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0016874,molecular_function ligase activity;GO:0030141,cellular_component secretory granule;GO:0030424,cellular_component axon;GO:0042995,cellular_component cell projection;GO:0046983,molecular_function protein dimerization activity;GO:0070062,cellular_component extracellular exosome;GO:0070150,biological_process mitochondrial glycyl-tRNA aminoacylation	GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14]; K01880	glycyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:4162]
ENSG00000163359	285.41	264.26	292.86	264.18	222.80	253.23	0.198541397314871	11.308734982309	0.00686392570078039	0.0899703376175152	2:237324002-237414375:-	COL6A3	18;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005589,cellular_component collagen type VI trimer;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0007517,biological_process muscle organ development;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030198,biological_process extracellular matrix organization;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0042383,cellular_component sarcolemma;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	COL6A; collagen, type VI, alpha; K06238	collagen type VI alpha 3 chain [Source:HGNC Symbol%3BAcc:HGNC:2213]
ENSG00000104889	39.37	38.67	32.57	42.99	50.73	40.53	-0.268421678211146	5.20092566842882	0.00693840786292057	0.0908506928295707	19:12802062-12813638:+	RNASEH2A	20;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006298,biological_process mismatch repair;GO:0006401,biological_process RNA catabolic process;GO:0016070,biological_process RNA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0032299,cellular_component ribonuclease H2 complex;GO:0043137,biological_process DNA replication, removal of RNA primer;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]; K10743	ribonuclease H2 subunit A [Source:HGNC Symbol%3BAcc:HGNC:18518]
ENSG00000188906	6.14	5.80	5.87	6.19	8.37	6.93	-0.257834417363241	5.66221021456537	0.00694928871944321	0.0908972822702304	12:40196743-40369285:+	LRRK2	157;GO:0000149,molecular_function SNARE binding;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003779,molecular_function actin binding;GO:0003924,molecular_function GTPase activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0006979,biological_process response to oxidative stress;GO:0007005,biological_process mitochondrion organization;GO:0007030,biological_process Golgi organization;GO:0007040,biological_process lysosome organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007528,biological_process neuromuscular junction development;GO:0008017,molecular_function microtubule binding;GO:0008021,cellular_component synaptic vesicle;GO:0008340,biological_process determination of adult lifespan;GO:0009267,biological_process cellular response to starvation;GO:0010506,biological_process regulation of autophagy;GO:0010508,biological_process positive regulation of autophagy;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0010955,biological_process negative regulation of protein processing;GO:0014041,biological_process regulation of neuron maturation;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0017075,molecular_function syntaxin-1 binding;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019722,biological_process calcium-mediated signaling;GO:0021772,biological_process olfactory bulb development;GO:0022028,biological_process tangential migration from the subventricular zone to the olfactory bulb;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030276,molecular_function clathrin binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031966,cellular_component mitochondrial membrane;GO:0032091,biological_process negative regulation of protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032473,cellular_component cytoplasmic side of mitochondrial outer membrane;GO:0032839,cellular_component dendrite cytoplasm;GO:0034211,molecular_function GTP-dependent protein kinase activity;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0034613,biological_process cellular protein localization;GO:0035556,biological_process intracellular signal transduction;GO:0035564,biological_process regulation of kidney size;GO:0035640,biological_process exploration behavior;GO:0035641,biological_process locomotory exploration behavior;GO:0035751,biological_process regulation of lysosomal lumen pH;GO:0036479,molecular_function peroxidase inhibitor activity;GO:0039706,molecular_function co-receptor binding;GO:0040012,biological_process regulation of locomotion;GO:0042391,biological_process regulation of membrane potential;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043068,biological_process positive regulation of programmed cell death;GO:0043195,cellular_component terminal bouton;GO:0043204,cellular_component perikaryon;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044325,molecular_function ion channel binding;GO:0044753,cellular_component amphisome;GO:0044754,cellular_component autolysosome;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0046039,biological_process GTP metabolic process;GO:0046777,biological_process protein autophosphorylation;GO:0048312,biological_process intracellular distribution of mitochondria;GO:0048812,biological_process neuron projection morphogenesis;GO:0051018,molecular_function protein kinase A binding;GO:0051646,biological_process mitochondrion localization;GO:0051900,biological_process regulation of mitochondrial depolarization;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060159,biological_process regulation of dopamine receptor signaling pathway;GO:0060161,biological_process positive regulation of dopamine receptor signaling pathway;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070585,biological_process protein localization to mitochondrion;GO:0070997,biological_process neuron death;GO:0071287,biological_process cellular response to manganese ion;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090140,biological_process regulation of mitochondrial fission;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0090394,biological_process negative regulation of excitatory postsynaptic potential;GO:0097487,cellular_component multivesicular body, internal vesicle;GO:0098794,cellular_component postsynapse;GO:0099400,cellular_component caveola neck;GO:1901214,biological_process regulation of neuron death;GO:1901215,biological_process negative regulation of neuron death;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902499,biological_process positive regulation of protein autoubiquitination;GO:1902692,biological_process regulation of neuroblast proliferation;GO:1902803,biological_process regulation of synaptic vesicle transport;GO:1902823,biological_process negative regulation of late endosome to lysosome transport;GO:1902902,biological_process negative regulation of autophagosome assembly;GO:1903125,biological_process negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death;GO:1903215,biological_process negative regulation of protein targeting to mitochondrion;GO:1903217,biological_process negative regulation of protein processing involved in protein targeting to mitochondrion;GO:1903351,biological_process cellular response to dopamine;GO:1904713,molecular_function beta-catenin destruction complex binding;GO:1904887,biological_process Wnt signalosome assembly;GO:1905279,biological_process regulation of retrograde transport, endosome to Golgi;GO:1905289,biological_process regulation of CAMKK-AMPK signaling cascade;GO:1990909,cellular_component Wnt signalosome;GO:2000172,biological_process regulation of branching morphogenesis of a nerve;GO:2000300,biological_process regulation of synaptic vesicle exocytosis	LRRK2; leucine-rich repeat kinase 2 [EC:2.7.11.1]; K08844	leucine rich repeat kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:18618]
ENSG00000182934	50.33	50.63	47.49	43.66	44.90	44.23	0.171861784908274	6.48984312582638	0.00695964285780564	0.0909368913620436	11:126262918-126269144:-	SRPRA	16;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005047,molecular_function signal recognition particle binding;GO:0005525,molecular_function GTP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005785,cellular_component signal recognition particle receptor complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0070062,cellular_component extracellular exosome	SRPR; signal recognition particle receptor subunit alpha; K13431	SRP receptor alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:11307]
ENSG00000168634	2.03	4.11	5.80	2.15	2.17	0.76	1.23396023425852	-0.111865520491211	0.00697514638660043	0.0909561131061744	20:45702015-45708817:+	WFDC13	5;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity	NA	WAP four-disulfide core domain 13 [Source:HGNC Symbol%3BAcc:HGNC:16131]
ENSG00000196663	7.22	7.70	7.32	6.97	5.84	6.28	0.229199365589723	4.87510423615027	0.00697576892589044	0.0909561131061744	14:102362962-102502481:+	TECPR2	2;GO:0005515,molecular_function protein binding;GO:0006914,biological_process autophagy	NA	tectonin beta-propeller repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:19957]
ENSG00000173540	12.23	12.51	10.84	8.58	9.93	10.36	0.308031979534078	3.65362711261155	0.00698446963276262	0.0909739995293624	3:49716843-49723951:-	GMPPB	11;GO:0000166,molecular_function nucleotide binding;GO:0004475,molecular_function mannose-1-phosphate guanylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0009058,biological_process biosynthetic process;GO:0009298,biological_process GDP-mannose biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0070062,cellular_component extracellular exosome	GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]; K00966	GDP-mannose pyrophosphorylase B [Source:HGNC Symbol%3BAcc:HGNC:22932]
ENSG00000213347	8.43	8.95	8.85	10.42	11.08	10.99	-0.299824571975373	3.53227376602279	0.00702140114418249	0.0913591744263493	5:177301460-177312757:-	MXD3	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046983,molecular_function protein dimerization activity;GO:0090575,cellular_component RNA polymerase II transcription factor complex	NA	MAX dimerization protein 3 [Source:HGNC Symbol%3BAcc:HGNC:14008]
ENSG00000181722	0.35	0.56	0.60	0.81	0.72	1.17	-0.84783506284642	0.783890813246653	0.0070319818482653	0.0914010373638923	3:114314500-115147271:-	ZBTB20	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010629,biological_process negative regulation of gene expression;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 20 [Source:HGNC Symbol%3BAcc:HGNC:13503]
ENSG00000130511	36.36	33.95	33.98	39.88	39.48	39.32	-0.172937915013678	5.88066095910462	0.00705746964395346	0.0916363710150567	19:18418863-18434562:+	SSBP4	10;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	single stranded DNA binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:15676]
ENSG00000120254	33.57	27.19	31.05	37.41	33.07	37.35	-0.217906933606446	6.68521782319871	0.00708802113276498	0.0919368927074312	6:150865548-151101887:+	MTHFD1L	22;GO:0000166,molecular_function nucleotide binding;GO:0001843,biological_process neural tube closure;GO:0004329,molecular_function formate-tetrahydrofolate ligase activity;GO:0004477,molecular_function methenyltetrahydrofolate cyclohydrolase activity;GO:0004488,molecular_function methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006730,biological_process one-carbon metabolic process;GO:0006760,biological_process folic acid-containing compound metabolic process;GO:0009113,biological_process purine nucleobase biosynthetic process;GO:0009257,biological_process 10-formyltetrahydrofolate biosynthetic process;GO:0015942,biological_process formate metabolic process;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0042803,molecular_function protein homodimerization activity;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046655,biological_process folic acid metabolic process;GO:0048702,biological_process embryonic neurocranium morphogenesis;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0055114,biological_process oxidation-reduction process	MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]; K13402	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [Source:HGNC Symbol%3BAcc:HGNC:21055]
ENSG00000120647	7.38	7.12	6.59	8.80	10.46	7.88	-0.350488048921501	3.57771316161355	0.00710282176293358	0.0920326999408085	12:389272-442645:+	CCDC77	2;GO:0005813,cellular_component centrosome;GO:0016020,cellular_component membrane	NA	coiled-coil domain containing 77 [Source:HGNC Symbol%3BAcc:HGNC:28203]
ENSG00000151726	53.06	61.72	50.38	42.80	52.72	44.86	0.244979035372279	6.8575050009019	0.00713611737408078	0.0923677006928725	4:184755594-184826818:-	ACSL1	37;GO:0000166,molecular_function nucleotide binding;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0010033,biological_process response to organic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0015908,biological_process fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0031090,cellular_component organelle membrane;GO:0033211,biological_process adiponectin-activated signaling pathway;GO:0034201,biological_process response to oleic acid;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0042178,biological_process xenobiotic catabolic process;GO:0042493,biological_process response to drug;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043651,biological_process linoleic acid metabolic process;GO:0044539,biological_process long-chain fatty acid import;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0102391,molecular_function decanoate--CoA ligase activity	ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]; K01897	acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol%3BAcc:HGNC:3569]
ENSG00000178057	79.71	82.93	80.80	68.09	74.88	72.10	0.188895356237082	5.40294309676124	0.00715751225459081	0.0925481246002456	3:49020458-49023495:+	NDUFAF3	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; K09008	NADH:ubiquinone oxidoreductase complex assembly factor 3 [Source:HGNC Symbol%3BAcc:HGNC:29918]
ENSG00000115107	39.73	32.65	40.00	33.51	29.98	33.57	0.227033986333341	5.88047284360332	0.00718196859323697	0.0927677171153491	2:119223830-119265652:+	STEAP3	24;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005771,cellular_component multivesicular body;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008823,molecular_function cupric reductase activity;GO:0009306,biological_process protein secretion;GO:0010008,cellular_component endosome membrane;GO:0015677,biological_process copper ion import;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016723,molecular_function oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor;GO:0033572,biological_process transferrin transport;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0052851,molecular_function ferric-chelate reductase (NADPH) activity;GO:0055072,biological_process iron ion homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0098706,biological_process ferric iron import across plasma membrane	STEAP3, TSAP6; metalloreductase STEAP3 [EC:1.16.1.-]; K10142	STEAP3 metalloreductase [Source:HGNC Symbol%3BAcc:HGNC:24592]
ENSG00000106772	3.45	4.48	3.53	2.85	3.35	3.27	0.278334222076293	5.05667382693318	0.00721163693041887	0.0930541052154776	9:76611375-76906087:-	PRUNE2	6;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016462,molecular_function pyrophosphatase activity;GO:0046872,molecular_function metal ion binding	NA	prune homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:25209]
ENSG00000151876	26.72	24.26	27.85	23.79	20.56	23.38	0.234412680661712	4.90778051194044	0.00722760542763378	0.0931633085910884	5:41925253-41941743:+	FBXO4	25;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007568,biological_process aging;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019725,biological_process cellular homeostasis;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031647,biological_process regulation of protein stability;GO:0031648,biological_process protein destabilization;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0035726,biological_process common myeloid progenitor cell proliferation;GO:0042803,molecular_function protein homodimerization activity;GO:0043687,biological_process post-translational protein modification;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071479,biological_process cellular response to ionizing radiation;GO:1900181,biological_process negative regulation of protein localization to nucleus;GO:1902916,biological_process positive regulation of protein polyubiquitination;GO:2000001,biological_process regulation of DNA damage checkpoint	FBXO4; F-box protein 4; K10291	F-box protein 4 [Source:HGNC Symbol%3BAcc:HGNC:13583]
ENSG00000275066	12.77	12.59	12.53	11.42	11.37	11.05	0.175412148188611	5.63013740611364	0.00732190000358664	0.0942808555441089	17:37514796-37609496:-	SYNRG	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030121,cellular_component AP-1 adaptor complex	NA	synergin gamma [Source:HGNC Symbol%3BAcc:HGNC:557]
ENSG00000169018	12.80	11.18	13.15	15.17	15.20	13.91	-0.234243447698451	4.68714500952291	0.00735673224820236	0.094581129514182	15:68277802-68295865:+	FEM1B	16;GO:0002070,biological_process epithelial cell maturation;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0051438,biological_process regulation of ubiquitin-protein transferase activity;GO:0060442,biological_process branching involved in prostate gland morphogenesis;GO:0060743,biological_process epithelial cell maturation involved in prostate gland development;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000001,biological_process regulation of DNA damage checkpoint	NA	fem-1 homolog B [Source:HGNC Symbol%3BAcc:HGNC:3649]
ENSG00000120256	19.76	19.33	18.66	17.54	16.65	16.07	0.212415553934722	4.82041803862806	0.00736662251182309	0.094581129514182	6:149818797-149864026:-	LRP11	11;GO:0005886,cellular_component plasma membrane;GO:0009408,biological_process response to heat;GO:0009409,biological_process response to cold;GO:0009414,biological_process response to water deprivation;GO:0009612,biological_process response to mechanical stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033555,biological_process multicellular organismal response to stress;GO:0035902,biological_process response to immobilization stress;GO:0042594,biological_process response to starvation;GO:0051219,molecular_function phosphoprotein binding	NA	LDL receptor related protein 11 [Source:HGNC Symbol%3BAcc:HGNC:16936]
ENSG00000135930	47.64	52.78	43.57	54.59	56.43	55.72	-0.204284729592938	5.88348313731183	0.00737853335273621	0.094581129514182	2:232550051-232583644:+	EIF4E2	14;GO:0000339,molecular_function RNA cap binding;GO:0001701,biological_process in utero embryonic development;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005845,cellular_component mRNA cap binding complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0017148,biological_process negative regulation of translation;GO:0031625,molecular_function ubiquitin protein ligase binding	EIF4E; translation initiation factor 4E; K03259	eukaryotic translation initiation factor 4E family member 2 [Source:HGNC Symbol%3BAcc:HGNC:3293]
ENSG00000178075	3.77	4.15	3.96	5.10	4.64	5.28	-0.333765481973445	3.21001367072874	0.00738039292785323	0.094581129514182	3:113828181-113947174:+	GRAMD1C	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	GRAM domain containing 1C [Source:HGNC Symbol%3BAcc:HGNC:25252]
ENSG00000143194	1.63	1.32	0.90	0.52	0.82	0.76	0.88790093535558	0.517882422282524	0.00738331704658361	0.094581129514182	1:166975581-167022214:+	MAEL	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000902,biological_process cell morphogenesis;GO:0001741,cellular_component XY body;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007129,biological_process synapsis;GO:0007140,biological_process male meiosis;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009566,biological_process fertilization;GO:0010629,biological_process negative regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0030849,cellular_component autosome;GO:0031047,biological_process gene silencing by RNA;GO:0033391,cellular_component chromatoid body;GO:0034587,biological_process piRNA metabolic process;GO:0043046,biological_process DNA methylation involved in gamete generation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043186,cellular_component P granule;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046620,biological_process regulation of organ growth;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051321,biological_process meiotic cell cycle;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0071547,cellular_component piP-body	NA	maelstrom spermatogenic transposon silencer [Source:HGNC Symbol%3BAcc:HGNC:25929]
ENSG00000117791	6.88	6.54	6.74	10.47	6.87	10.51	-0.454149948746051	3.08873573876949	0.00742532007943734	0.0950211321093358	1:220748224-220784815:+	MARC2	17;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005777,cellular_component peroxisome;GO:0006805,biological_process xenobiotic metabolic process;GO:0008940,molecular_function nitrate reductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030151,molecular_function molybdenum ion binding;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042126,biological_process nitrate metabolic process;GO:0043546,molecular_function molybdopterin cofactor binding;GO:0051410,biological_process detoxification of nitrogen compound;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	mitochondrial amidoxime reducing component 2 [Source:HGNC Symbol%3BAcc:HGNC:26064]
ENSG00000128298	0.80	0.42	0.51	1.27	0.91	1.11	-0.872976021095247	0.590725919292734	0.00745801652363962	0.0951893639421127	22:38084888-38110670:-	BAIAP2L2	19;GO:0005543,molecular_function phospholipid binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007009,biological_process plasma membrane organization;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008289,molecular_function lipid binding;GO:0012506,cellular_component vesicle membrane;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0044291,cellular_component cell-cell contact zone;GO:0051017,biological_process actin filament bundle assembly;GO:0051764,biological_process actin crosslink formation;GO:0061024,biological_process membrane organization;GO:0071439,cellular_component clathrin complex;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization	NA	BAI1 associated protein 2 like 2 [Source:HGNC Symbol%3BAcc:HGNC:26203]
ENSG00000138166	23.30	24.22	21.47	20.21	18.63	20.33	0.228588866787853	4.62735595214421	0.00745819086583493	0.0951893639421127	10:110497837-110511544:+	DUSP5	17;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0000188,biological_process inactivation of MAPK activity;GO:0001706,biological_process endoderm formation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035970,biological_process peptidyl-threonine dephosphorylation	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 5 [Source:HGNC Symbol%3BAcc:HGNC:3071]
ENSG00000113712	130.43	116.91	126.21	148.04	132.89	147.23	-0.184017511660669	7.36006785052348	0.00746722685788882	0.0951893639421127	5:149492196-149551552:-	CSNK1A1	45;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000902,biological_process cell morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0006909,biological_process phagocytosis;GO:0007030,biological_process Golgi organization;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030877,cellular_component beta-catenin destruction complex;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045095,cellular_component keratin filament;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0051301,biological_process cell division;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1904424,biological_process regulation of GTP binding;GO:1904885,biological_process beta-catenin destruction complex assembly;GO:1904886,biological_process beta-catenin destruction complex disassembly	CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]; K08957	casein kinase 1 alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:2451]
ENSG00000148468	21.40	23.77	20.26	19.04	19.74	18.54	0.198781213075898	5.77336379384036	0.0074758951520644	0.0951893639421127	10:15211642-15371062:-	FAM171A1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	family with sequence similarity 171 member A1 [Source:HGNC Symbol%3BAcc:HGNC:23522]
ENSG00000131669	32.68	26.41	41.16	27.09	24.45	26.22	0.387113441721447	3.78000579300118	0.00747680897797147	0.0951893639421127	9:93121488-93134288:-	NINJ1	8;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0005515,molecular_function protein binding;GO:0007155,biological_process cell adhesion;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042246,biological_process tissue regeneration;GO:1990384,biological_process hyaloid vascular plexus regression	NA	ninjurin 1 [Source:HGNC Symbol%3BAcc:HGNC:7824]
ENSG00000138050	7.56	7.78	7.57	8.49	9.70	9.73	-0.276122220528791	3.88313518783211	0.0074869242778872	0.0952204826448912	2:39736059-39779267:-	THUMPD2	6;GO:0003723,molecular_function RNA binding;GO:0008168,molecular_function methyltransferase activity;GO:0016423,molecular_function tRNA (guanine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	THUMP domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:14890]
ENSG00000081692	11.64	11.97	11.23	10.13	10.10	8.76	0.276424719684725	3.8962147526817	0.00752109859226067	0.0955327319904557	1:227730424-227735411:-	JMJD4	1;GO:0005515,molecular_function protein binding	NA	jumonji domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25724]
ENSG00000100429	17.07	15.90	19.84	14.85	14.13	16.01	0.246334655103252	5.0408613750515	0.00753260313770194	0.0955327319904557	22:50245182-50251405:-	HDAC10	21;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006476,biological_process protein deacetylation;GO:0014003,biological_process oligodendrocyte development;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033558,molecular_function protein deacetylase activity;GO:0042826,molecular_function histone deacetylase binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070932,biological_process histone H3 deacetylation	HDAC6; histone deacetylase 6 [EC:3.5.1.98]; K11407	histone deacetylase 10 [Source:HGNC Symbol%3BAcc:HGNC:18128]
ENSG00000158292	1.31	1.05	1.01	0.53	0.83	0.62	0.786314040436475	0.826892719768155	0.00753456413587821	0.0955327319904557	1:6247345-6260975:-	GPR153	7;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 153 [Source:HGNC Symbol%3BAcc:HGNC:23618]
ENSG00000106327	0.59	0.69	1.00	0.36	0.58	0.34	0.85944643294111	0.697998140158908	0.00754628048276067	0.0955836526862329	7:100620415-100642779:-	TFR2	24;GO:0004998,molecular_function transferrin receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006826,biological_process iron ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006953,biological_process acute-phase response;GO:0009897,cellular_component external side of plasma membrane;GO:0010039,biological_process response to iron ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033572,biological_process transferrin transport;GO:0039706,molecular_function co-receptor binding;GO:0045807,biological_process positive regulation of endocytosis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0055072,biological_process iron ion homeostasis;GO:0071281,biological_process cellular response to iron ion;GO:0090277,biological_process positive regulation of peptide hormone secretion;GO:0098707,biological_process ferrous iron import across plasma membrane;GO:1903319,biological_process positive regulation of protein maturation;GO:1990712,cellular_component HFE-transferrin receptor complex	NA	transferrin receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:11762]
ENSG00000166262	1.59	1.80	1.97	1.96	3.05	3.08	-0.583047486314887	1.94861496056195	0.00758179711499437	0.0959356244530328	15:49326961-49620931:-	FAM227B	NA	NA	family with sequence similarity 227 member B [Source:HGNC Symbol%3BAcc:HGNC:26543]
ENSG00000135241	23.00	23.67	22.84	18.77	21.43	21.16	0.190142910215571	5.68101608429047	0.00759265842673348	0.0959740064225168	7:108470421-108569666:-	PNPLA8	29;GO:0000139,cellular_component Golgi membrane;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0004622,molecular_function lysophospholipase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0008152,biological_process metabolic process;GO:0008219,biological_process cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0034638,biological_process phosphatidylcholine catabolic process;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0043651,biological_process linoleic acid metabolic process;GO:0046338,biological_process phosphatidylethanolamine catabolic process;GO:0047499,molecular_function calcium-independent phospholipase A2 activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050482,biological_process arachidonic acid secretion	NA	patatin like phospholipase domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:28900]
ENSG00000197587	1.54	0.58	1.48	2.55	1.32	3.01	-0.881780061950088	1.14532193018115	0.00760417848096509	0.0959740064225168	1:46506995-46514226:+	DMBX1	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0008343,biological_process adult feeding behavior;GO:0008344,biological_process adult locomotory behavior;GO:0042803,molecular_function protein homodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0048589,biological_process developmental growth	NA	diencephalon/mesencephalon homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:19026]
ENSG00000166797	91.76	94.39	87.21	79.49	83.05	80.35	0.180298583510126	5.61451455986346	0.0076080256440632	0.0959740064225168	15:64072558-64094018:-	FAM96A	10;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007059,biological_process chromosome segregation;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	family with sequence similarity 96 member A [Source:HGNC Symbol%3BAcc:HGNC:26235]
ENSG00000092010	317.99	300.02	311.92	351.14	331.26	373.06	-0.170525256102349	8.10675595308816	0.00763261403383239	0.0961864345197578	14:24136157-24138967:+	PSME1	36;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008537,cellular_component proteasome activator complex;GO:0010950,biological_process positive regulation of endopeptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0019884,biological_process antigen processing and presentation of exogenous antigen;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061133,molecular_function endopeptidase activator activity;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	PSME1; proteasome activator subunit 1 (PA28 alpha); K06696	proteasome activator subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:9568]
ENSG00000109536	13.17	11.45	13.26	15.99	14.22	16.85	-0.294520171088675	3.78875181836763	0.00767443092234381	0.0966153255974175	4:189940787-189963204:+	FRG1	18;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0007517,biological_process muscle organ development;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0030018,cellular_component Z disc;GO:0042254,biological_process ribosome biogenesis;GO:0051015,molecular_function actin filament binding;GO:0055120,cellular_component striated muscle dense body;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	FSHD region gene 1 [Source:HGNC Symbol%3BAcc:HGNC:3954]
ENSG00000100060	23.25	16.07	22.56	29.77	21.19	30.66	-0.381767794193792	4.7904188081114	0.00770756067923911	0.0969340939325178	22:37469062-37486401:-	MFNG	15;GO:0000139,cellular_component Golgi membrane;GO:0002315,biological_process marginal zone B cell differentiation;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030173,cellular_component integral component of Golgi membrane;GO:0032092,biological_process positive regulation of protein binding;GO:0033829,molecular_function O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0046872,molecular_function metal ion binding	FNG; fringe [EC:2.4.1.222]; K05948	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:HGNC Symbol%3BAcc:HGNC:7038]
ENSG00000257103	89.48	84.07	90.40	98.22	98.26	102.28	-0.165744608221787	7.11221994935146	0.00775100724753551	0.0973818349834598	19:34172503-34229515:+	LSM14A	15;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0007275,biological_process multicellular organism development;GO:0010494,cellular_component cytoplasmic stress granule;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0039529,biological_process RIG-I signaling pathway;GO:0051607,biological_process defense response to virus;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway	NA	LSM14A%2C mRNA processing body assembly factor [Source:HGNC Symbol%3BAcc:HGNC:24489]
ENSG00000137942	28.41	27.02	29.49	30.82	31.46	36.39	-0.203438869939199	5.81568336202301	0.00777501783354636	0.0975847283799909	1:93448130-93554661:+	FNBP1L	23;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006897,biological_process endocytosis;GO:0006900,biological_process membrane budding;GO:0006914,biological_process autophagy;GO:0008289,molecular_function lipid binding;GO:0010324,biological_process membrane invagination;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0030050,biological_process vesicle transport along actin filament;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045296,molecular_function cadherin binding;GO:0051020,molecular_function GTPase binding;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0060271,biological_process cilium morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0097320,biological_process membrane tubulation	NA	formin binding protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:20851]
ENSG00000124228	28.82	28.19	29.04	34.02	30.94	32.84	-0.172578765841725	6.27664239878906	0.00778592354267883	0.0976228979144164	20:49219294-49244077:+	DDX27	15;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016787,molecular_function hydrolase activity;GO:0042254,biological_process ribosome biogenesis	NA	DEAD-box helicase 27 [Source:HGNC Symbol%3BAcc:HGNC:15837]
ENSG00000170266	116.54	113.91	113.71	103.78	103.56	104.70	0.153197016010694	7.89795904186197	0.00783987088222366	0.0982001183259761	3:32996607-33097230:-	GLB1	29;GO:0004308,molecular_function exo-alpha-sialidase activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004565,molecular_function beta-galactosidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005773,cellular_component vacuole;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016936,molecular_function galactoside binding;GO:0019388,biological_process galactose catabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0042340,biological_process keratan sulfate catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0044262,biological_process cellular carbohydrate metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051413,biological_process response to cortisone;GO:0070062,cellular_component extracellular exosome;GO:1904016,biological_process response to Thyroglobulin triiodothyronine;GO:1904813,cellular_component ficolin-1-rich granule lumen	GLB1, ELNR1; beta-galactosidase [EC:3.2.1.23]; K12309	galactosidase beta 1 [Source:HGNC Symbol%3BAcc:HGNC:4298]
ENSG00000127990	108.76	100.49	108.76	98.45	89.57	96.09	0.175277793338131	7.32153850853714	0.00788107274104777	0.0986166894502278	7:94585229-94656209:-	SGCE	17;GO:0003012,biological_process muscle system process;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007160,biological_process cell-matrix adhesion;GO:0007517,biological_process muscle organ development;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016012,cellular_component sarcoglycan complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0032590,cellular_component dendrite membrane;GO:0042383,cellular_component sarcolemma;GO:0042995,cellular_component cell projection;GO:0061024,biological_process membrane organization	NA	sarcoglycan epsilon [Source:HGNC Symbol%3BAcc:HGNC:10808]
ENSG00000113272	14.22	14.72	12.71	18.45	14.85	19.03	-0.323193963027463	3.8503422265145	0.00792633670106947	0.0990831998694616	5:157731196-157741448:+	THG1L	17;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008193,molecular_function tRNA guanylyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization	NA	tRNA-histidine guanylyltransferase 1 like [Source:HGNC Symbol%3BAcc:HGNC:26053]
ENSG00000112812	3.11	2.36	2.63	3.98	3.64	3.56	-0.437280244806235	2.36404916385103	0.00795468842847576	0.0993375729000701	6:27247700-27256624:+	PRSS16	11;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008239,molecular_function dipeptidyl-peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030163,biological_process protein catabolic process;GO:0031410,cellular_component cytoplasmic vesicle	NA	protease%2C serine 16 [Source:HGNC Symbol%3BAcc:HGNC:9480]
ENSG00000111247	22.51	21.52	21.87	26.10	26.79	24.45	-0.216170023661448	4.68633441626339	0.00804698503352544	0.100373550068171	12:4538797-4560048:+	RAD51AP1	18;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0036297,biological_process interstrand cross-link repair;GO:0043234,cellular_component protein complex;GO:0071479,biological_process cellular response to ionizing radiation	NA	RAD51 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16956]
ENSG00000176014	74.59	82.56	68.93	85.52	94.22	83.33	-0.208499856546128	7.06296510763359	0.00806143812580661	0.100373550068171	18:12307668-12344320:+	TUBB6	13;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0070062,cellular_component extracellular exosome	TUBB; tubulin beta; K07375	tubulin beta 6 class V [Source:HGNC Symbol%3BAcc:HGNC:20776]
ENSG00000169047	10.79	10.08	12.25	9.77	9.34	9.64	0.219392411674333	5.27123276495667	0.00806190521372481	0.100373550068171	2:226731316-226799759:-	IRS1	44;GO:0000165,biological_process MAPK cascade;GO:0001784,molecular_function phosphotyrosine binding;GO:0004871,molecular_function signal transducer activity;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005080,molecular_function protein kinase C binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005899,cellular_component insulin receptor complex;GO:0005901,cellular_component caveola;GO:0007165,biological_process signal transduction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0032000,biological_process positive regulation of fatty acid beta-oxidation;GO:0032868,biological_process response to insulin;GO:0032869,biological_process cellular response to insulin stimulus;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042169,molecular_function SH2 domain binding;GO:0042593,biological_process glucose homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045725,biological_process positive regulation of glycogen biosynthetic process;GO:0046326,biological_process positive regulation of glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	IRS1; insulin receptor substrate 1; K16172	insulin receptor substrate 1 [Source:HGNC Symbol%3BAcc:HGNC:6125]
ENSG00000178927	35.64	32.56	35.69	29.34	32.45	27.72	0.231819697975248	4.80140889462512	0.00807464627802656	0.100431447143431	17:82442588-82450829:-	C17orf62	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 17 open reading frame 62 [Source:HGNC Symbol%3BAcc:HGNC:28672]
ENSG00000160408	37.38	39.64	43.40	34.24	36.84	34.10	0.207387122300501	5.40870126756505	0.00808947493338828	0.100453854951782	9:127885320-127905408:-	ST6GALNAC6	20;GO:0000139,cellular_component Golgi membrane;GO:0001574,biological_process ganglioside biosynthetic process;GO:0001665,molecular_function alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0006677,biological_process glycosylceramide metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008373,molecular_function sialyltransferase activity;GO:0009100,biological_process glycoprotein metabolic process;GO:0009311,biological_process oligosaccharide metabolic process;GO:0009312,biological_process oligosaccharide biosynthetic process;GO:0009988,biological_process cell-cell recognition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0097503,biological_process sialylation	SIAT7F, ST6GalNAc VI; N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7F) [EC:2.4.99.-]; K03376	ST6 N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:23364]
ENSG00000167780	0.45	0.43	0.14	0.67	1.02	0.54	-1.11443228436563	0.000952144047444663	0.00809448618304903	0.100453854951782	12:53103517-53124538:+	SOAT2	22;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0004772,molecular_function sterol O-acyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005903,cellular_component brush border;GO:0006629,biological_process lipid metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0010742,biological_process macrophage derived foam cell differentiation;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030299,biological_process intestinal cholesterol absorption;GO:0033344,biological_process cholesterol efflux;GO:0034379,biological_process very-low-density lipoprotein particle assembly;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0034435,biological_process cholesterol esterification;GO:0034736,molecular_function cholesterol O-acyltransferase activity;GO:0042632,biological_process cholesterol homeostasis	SOAT; sterol O-acyltransferase [EC:2.3.1.26]; K00637	sterol O-acyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:11178]
ENSG00000111319	10.81	11.21	10.53	9.16	10.17	8.15	0.256110097665719	4.47188675828655	0.00810072575579906	0.100453854951782	12:6346842-6377730:-	SCNN1A	25;GO:0005272,molecular_function sodium channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0015280,molecular_function ligand-gated sodium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0031514,cellular_component motile cilium;GO:0034220,biological_process ion transmembrane transport;GO:0034706,cellular_component sodium channel complex;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042995,cellular_component cell projection;GO:0050699,molecular_function WW domain binding;GO:0050891,biological_process multicellular organismal water homeostasis;GO:0050896,biological_process response to stimulus;GO:0050909,biological_process sensory perception of taste;GO:0055078,biological_process sodium ion homeostasis;GO:0060170,cellular_component ciliary membrane;GO:0070062,cellular_component extracellular exosome	SCNN1A, ENACA; amiloride-sensitive sodium channel subunit alpha; K04824	sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:10599]
ENSG00000168297	33.08	29.92	34.67	41.74	36.41	35.88	-0.208737851867361	6.04394944721484	0.0081457860913022	0.100623086191392	3:58332879-58426126:+	PXK	12;GO:0003779,molecular_function actin binding;GO:0004672,molecular_function protein kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0016020,cellular_component membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0050804,biological_process modulation of synaptic transmission	NA	PX domain containing serine/threonine kinase like [Source:HGNC Symbol%3BAcc:HGNC:23326]
ENSG00000167004	571.46	567.84	545.89	501.77	520.78	507.38	0.151180045809089	9.76221200326458	0.00814690071670706	0.100623086191392	15:43746391-43773279:+	PDIA3	32;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003723,molecular_function RNA binding;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004629,molecular_function phospholipase C activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005925,cellular_component focal adhesion;GO:0006457,biological_process protein folding;GO:0006508,biological_process proteolysis;GO:0006606,biological_process protein import into nucleus;GO:0006621,biological_process protein retention in ER lumen;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0015036,molecular_function disulfide oxidoreductase activity;GO:0015037,molecular_function peptide disulfide oxidoreductase activity;GO:0016853,molecular_function isomerase activity;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042470,cellular_component melanosome;GO:0043209,cellular_component myelin sheath;GO:0045335,cellular_component phagocytic vesicle;GO:0045454,biological_process cell redox homeostasis;GO:0055038,cellular_component recycling endosome membrane;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	PDIA3, GRP58; protein disulfide-isomerase A3 [EC:5.3.4.1]; K08056	protein disulfide isomerase family A member 3 [Source:HGNC Symbol%3BAcc:HGNC:4606]
ENSG00000134153	79.58	81.88	77.45	70.02	68.63	74.39	0.174735955928191	5.77678162618299	0.00815387446598132	0.100623086191392	15:34084016-34101948:-	EMC7	5;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:24301]
ENSG00000137364	140.29	150.43	128.48	155.75	168.81	157.95	-0.193002080167202	6.78976409738994	0.00816384902098097	0.100623086191392	6:18128310-18155074:-	TPMT	9;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0008119,molecular_function thiopurine S-methyltransferase activity;GO:0008168,molecular_function methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0070062,cellular_component extracellular exosome	TPMT, tpmT; thiopurine S-methyltransferase [EC:2.1.1.67]; K00569	thiopurine S-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:12014]
ENSG00000106927	42.99	41.49	43.65	38.92	36.48	38.87	0.17818219181534	5.62127072948702	0.00816458675061198	0.100623086191392	9:114060126-114078472:-	AMBP	27;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007155,biological_process cell adhesion;GO:0007565,biological_process female pregnancy;GO:0009986,cellular_component cell surface;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016032,biological_process viral process;GO:0018298,biological_process protein-chromophore linkage;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0019862,molecular_function IgA binding;GO:0020037,molecular_function heme binding;GO:0030163,biological_process protein catabolic process;GO:0030414,molecular_function peptidase inhibitor activity;GO:0036094,molecular_function small molecule binding;GO:0042167,biological_process heme catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046904,molecular_function calcium oxalate binding;GO:0050777,biological_process negative regulation of immune response;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	NA	alpha-1-microglobulin/bikunin precursor [Source:HGNC Symbol%3BAcc:HGNC:453]
ENSG00000100628	0.32	0.39	0.63	0.80	0.65	1.11	-0.906867239334966	0.541564478596709	0.00818042848118312	0.100623086191392	14:93934152-93976791:-	ASB2	12;GO:0000209,biological_process protein polyubiquitination;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0031466,cellular_component Cul5-RING ubiquitin ligase complex;GO:0035556,biological_process intracellular signal transduction;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0045445,biological_process myoblast differentiation;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ankyrin repeat and SOCS box containing 2 [Source:HGNC Symbol%3BAcc:HGNC:16012]
ENSG00000099338	1.45	1.14	1.64	1.06	0.97	1.04	0.491155430768242	2.18445329926782	0.00818219934046593	0.100623086191392	19:38335774-38370943:+	CATSPERG	10;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0032570,biological_process response to progesterone;GO:0035036,biological_process sperm-egg recognition;GO:0036128,cellular_component CatSper complex;GO:0097228,cellular_component sperm principal piece	NA	cation channel sperm associated auxiliary subunit gamma [Source:HGNC Symbol%3BAcc:HGNC:25243]
ENSG00000170584	74.97	87.04	81.57	94.90	88.89	99.28	-0.210323643654591	5.3753990368637	0.00818741084320074	0.100623086191392	5:163446525-163460140:-	NUDCD2	16;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006457,biological_process protein folding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0032502,biological_process developmental process;GO:0051082,molecular_function unfolded protein binding;GO:0070062,cellular_component extracellular exosome	NA	NudC domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30535]
ENSG00000160752	167.97	183.38	140.80	140.03	150.57	127.98	0.244524369856809	7.6863184765605	0.00819208999441103	0.100623086191392	1:155308747-155320666:+	FDPS	22;GO:0003723,molecular_function RNA binding;GO:0004161,molecular_function dimethylallyltranstransferase activity;GO:0004337,molecular_function geranyltranstransferase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016126,biological_process sterol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0033384,biological_process geranyl diphosphate biosynthetic process;GO:0045337,biological_process farnesyl diphosphate biosynthetic process;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046872,molecular_function metal ion binding	FDPS; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]; K00787	farnesyl diphosphate synthase [Source:HGNC Symbol%3BAcc:HGNC:3631]
ENSG00000159023	15.56	16.16	17.19	14.96	14.36	13.83	0.193357457869371	5.46438526714218	0.00819933416652355	0.100623086191392	1:28887090-29120046:+	EPB41	36;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008360,biological_process regulation of cell shape;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0014731,cellular_component spectrin-associated cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030507,molecular_function spectrin binding;GO:0030863,cellular_component cortical cytoskeleton;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031032,biological_process actomyosin structure organization;GO:0032092,biological_process positive regulation of protein binding;GO:0043234,cellular_component protein complex;GO:0047485,molecular_function protein N-terminus binding;GO:0051219,molecular_function phosphoprotein binding;GO:0051301,biological_process cell division;GO:0099738,cellular_component cell cortex region;GO:1904778,biological_process positive regulation of protein localization to cell cortex	NA	erythrocyte membrane protein band 4.1 [Source:HGNC Symbol%3BAcc:HGNC:3377]
ENSG00000137965	22.20	21.54	22.65	17.80	18.37	21.13	0.224222007464129	4.8293255361898	0.00820354170834515	0.100623086191392	1:78649795-78664078:+	IFI44	2;GO:0005737,cellular_component cytoplasm;GO:0009615,biological_process response to virus	NA	interferon induced protein 44 [Source:HGNC Symbol%3BAcc:HGNC:16938]
ENSG00000164308	48.66	50.06	49.60	53.53	57.64	56.23	-0.163185728086427	7.33804301292241	0.00822303688994585	0.100762642561597	5:96875938-96919716:+	ERAP2	24;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0004175,molecular_function endopeptidase activity;GO:0004177,molecular_function aminopeptidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008217,biological_process regulation of blood pressure;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019885,biological_process antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity	NA	endoplasmic reticulum aminopeptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:29499]
ENSG00000128050	232.59	234.93	214.22	262.05	254.68	253.44	-0.164616316837276	8.29429016108579	0.00823539546664346	0.100814560086238	4:56435740-56464579:+	PAICS	20;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004638,molecular_function phosphoribosylaminoimidazole carboxylase activity;GO:0004639,molecular_function phosphoribosylaminoimidazolesuccinocarboxamide synthase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006189,biological_process 'de novo' IMP biosynthetic process;GO:0008152,biological_process metabolic process;GO:0009113,biological_process purine nucleobase biosynthetic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0016874,molecular_function ligase activity;GO:0042802,molecular_function identical protein binding;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6]; K01587	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [Source:HGNC Symbol%3BAcc:HGNC:8587]
ENSG00000139645	12.65	12.52	13.32	11.48	11.63	10.96	0.18948657343436	5.29239170659791	0.00826616125951913	0.101091487403361	12:56237806-56258391:-	ANKRD52	1;GO:0005515,molecular_function protein binding	NA	ankyrin repeat domain 52 [Source:HGNC Symbol%3BAcc:HGNC:26614]
ENSG00000124571	20.57	20.85	21.44	24.21	22.68	24.40	-0.169835797663814	6.35442278851836	0.00831298028210934	0.101564000238015	6:43522329-43576075:-	XPO5	25;GO:0000049,molecular_function tRNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0010586,biological_process miRNA metabolic process;GO:0015031,biological_process protein transport;GO:0031047,biological_process gene silencing by RNA;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035281,biological_process pre-miRNA export from nucleus;GO:0042272,cellular_component nuclear RNA export factor complex;GO:0042565,cellular_component RNA nuclear export complex;GO:0046825,biological_process regulation of protein export from nucleus;GO:0070883,molecular_function pre-miRNA binding;GO:0090631,molecular_function pre-miRNA transporter activity;GO:1900370,biological_process positive regulation of RNA interference	XPO5; exportin-5; K14289	exportin 5 [Source:HGNC Symbol%3BAcc:HGNC:17675]
ENSG00000175463	1.21	1.35	1.37	0.78	0.39	0.99	0.84629688266477	0.59255026812421	0.00835070563630824	0.101908646125254	11:67403914-67410089:+	TBC1D10C	18;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0031527,cellular_component filopodium membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043312,biological_process neutrophil degranulation;GO:0050869,biological_process negative regulation of B cell activation;GO:0051534,biological_process negative regulation of NFAT protein import into nucleus;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0090630,biological_process activation of GTPase activity;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	TBC1 domain family member 10C [Source:HGNC Symbol%3BAcc:HGNC:24702]
ENSG00000004866	13.24	12.06	12.14	11.27	10.60	10.62	0.219921730812665	4.70147291867555	0.00835760909977513	0.101908646125254	7:116953237-117230103:+	ST7	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	suppression of tumorigenicity 7 [Source:HGNC Symbol%3BAcc:HGNC:11351]
ENSG00000185477	2.52	2.05	2.56	1.93	1.73	1.63	0.457379528005176	2.31555147377758	0.00838816421530455	0.102127481550447	4:89236385-89308010:-	GPRIN3	NA	NA	GPRIN family member 3 [Source:HGNC Symbol%3BAcc:HGNC:27733]
ENSG00000095209	15.83	16.14	15.67	12.39	13.84	13.38	0.275812443452644	3.70472226605709	0.00839201089031308	0.102127481550447	9:105694543-105776612:+	TMEM38B	16;GO:0005261,molecular_function cation channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0015269,molecular_function calcium-activated potassium channel activity;GO:0015672,biological_process monovalent inorganic cation transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0071805,biological_process potassium ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	transmembrane protein 38B [Source:HGNC Symbol%3BAcc:HGNC:25535]
ENSG00000166925	19.81	20.50	20.96	16.06	19.33	17.62	0.220494222587372	4.96784528287349	0.00840619643269677	0.10219991804022	7:100463358-100479279:-	TSC22D4	8;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070236,biological_process negative regulation of activation-induced cell death of T cells	NA	TSC22 domain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:21696]
ENSG00000171365	0.86	1.58	1.10	0.70	0.80	0.65	0.702557771687383	1.2853948776574	0.0084172958111826	0.10223472886909	X:49922614-50099235:+	CLCN5	25;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0005216,molecular_function ion channel activity;GO:0005247,molecular_function voltage-gated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005524,molecular_function ATP binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0007588,biological_process excretion;GO:0010008,cellular_component endosome membrane;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0045177,cellular_component apical part of cell;GO:0055085,biological_process transmembrane transport;GO:1902476,biological_process chloride transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport	NA	chloride voltage-gated channel 5 [Source:HGNC Symbol%3BAcc:HGNC:2023]
ENSG00000176619	45.45	44.91	42.10	49.07	49.83	51.23	-0.169551550035011	6.4565873360633	0.008466620298513	0.10273329204833	19:2427637-2456996:-	LMNB2	9;GO:0003674,molecular_function molecular_function;GO:0005198,molecular_function structural molecule activity;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005638,cellular_component lamin filament;GO:0005882,cellular_component intermediate filament;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane	LMNB; lamin B; K07611	lamin B2 [Source:HGNC Symbol%3BAcc:HGNC:6638]
ENSG00000271605	1.92	1.30	2.22	1.02	0.66	1.37	0.856503269619321	0.696596055558873	0.00848492970579311	0.102854914490244	17:64449036-64468643:+	MILR1	7;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033004,biological_process negative regulation of mast cell activation;GO:0042629,cellular_component mast cell granule;GO:0043303,biological_process mast cell degranulation	NA	mast cell immunoglobulin like receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:27570]
ENSG00000005187	23.69	23.95	26.83	27.75	29.00	28.82	-0.187349603227237	5.7138840139618	0.00852171084017152	0.103199996740536	16:20610242-20797581:+	ACSM3	20;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0003996,molecular_function acyl-CoA ligase activity;GO:0004321,molecular_function fatty-acyl-CoA synthase activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008152,biological_process metabolic process;GO:0008217,biological_process regulation of blood pressure;GO:0015645,molecular_function fatty acid ligase activity;GO:0016874,molecular_function ligase activity;GO:0042632,biological_process cholesterol homeostasis;GO:0046872,molecular_function metal ion binding;GO:0047760,molecular_function butyrate-CoA ligase activity	ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]; K01896	acyl-CoA synthetase medium chain family member 3 [Source:HGNC Symbol%3BAcc:HGNC:10522]
ENSG00000101447	23.12	26.99	24.02	28.53	30.46	27.17	-0.209678625809652	5.62722456278348	0.00854265467624609	0.10335279970394	20:38926311-38953106:+	FAM83D	20;GO:0000922,cellular_component spindle pole;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008283,biological_process cell proliferation;GO:0016477,biological_process cell migration;GO:0019894,molecular_function kinesin binding;GO:0019901,molecular_function protein kinase binding;GO:0032006,biological_process regulation of TOR signaling;GO:0042176,biological_process regulation of protein catabolic process;GO:0051301,biological_process cell division;GO:0051310,biological_process metaphase plate congression;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0097431,cellular_component mitotic spindle pole;GO:1902480,biological_process protein localization to mitotic spindle;GO:1902808,biological_process positive regulation of cell cycle G1/S phase transition	NA	family with sequence similarity 83 member D [Source:HGNC Symbol%3BAcc:HGNC:16122]
ENSG00000183690	0.22	0.60	0.56	0.10	0.27	0.22	1.17836951967347	-0.21400279704795	0.00855752992109245	0.103365181317883	X:44147881-44343672:-	EFHC2	3;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	EF-hand domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26233]
ENSG00000163346	50.70	52.40	51.58	45.59	48.21	45.14	0.166330088992547	6.87384161352786	0.00856033242526249	0.103365181317883	1:154944075-154956123:-	PBXIP1	10;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	PBX homeobox interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21199]
ENSG00000159231	10.96	10.24	10.54	9.28	7.03	8.55	0.365804076904208	2.99706656681013	0.00858127406843296	0.103517351808997	21:36134911-36146566:+	CBR3	13;GO:0000253,molecular_function 3-keto sterol reductase activity;GO:0004090,molecular_function carbonyl reductase (NADPH) activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006805,biological_process xenobiotic metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0042376,biological_process phylloquinone catabolic process;GO:0050890,biological_process cognition;GO:0055114,biological_process oxidation-reduction process;GO:0070402,molecular_function NADPH binding	CBR3; carbonyl reductase 3 [EC:1.1.1.184]; K00084	carbonyl reductase 3 [Source:HGNC Symbol%3BAcc:HGNC:1549]
ENSG00000169683	6.32	6.39	5.83	4.75	5.56	4.77	0.308425777523642	3.52464401425031	0.00860299968280424	0.103678674818106	17:82023301-82031151:+	LRRC45	8;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane	NA	leucine rich repeat containing 45 [Source:HGNC Symbol%3BAcc:HGNC:28302]
ENSG00000173898	1.85	2.03	1.98	2.36	2.23	2.46	-0.260172278144185	3.99550817450858	0.00863865582035407	0.104007405138754	11:66685247-66729226:-	SPTBN2	26;GO:0000165,biological_process MAPK cascade;GO:0003779,molecular_function actin binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005543,molecular_function phospholipid binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007010,biological_process cytoskeleton organization;GO:0007411,biological_process axon guidance;GO:0007416,biological_process synapse assembly;GO:0008091,cellular_component spectrin;GO:0016192,biological_process vesicle-mediated transport;GO:0016324,cellular_component apical plasma membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0021692,biological_process cerebellar Purkinje cell layer morphogenesis;GO:0030054,cellular_component cell junction;GO:0030534,biological_process adult behavior;GO:0035264,biological_process multicellular organism growth;GO:0043025,cellular_component neuronal cell body;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0051693,biological_process actin filament capping	NA	spectrin beta%2C non-erythrocytic 2 [Source:HGNC Symbol%3BAcc:HGNC:11276]
ENSG00000166323	1.13	0.93	1.24	1.73	1.89	1.94	-0.716674156012422	0.876054314915474	0.00866788199606464	0.104254517889428	11:108308518-108467531:-	C11orf65	1;GO:0005515,molecular_function protein binding	NA	chromosome 11 open reading frame 65 [Source:HGNC Symbol%3BAcc:HGNC:28519]
ENSG00000128564	4.21	3.78	4.12	6.66	4.37	5.31	-0.414929015864041	3.2377108795442	0.00867597816642062	0.104254517889428	7:101162508-101165593:-	VGF	24;GO:0001541,biological_process ovarian follicle development;GO:0002021,biological_process response to dietary excess;GO:0003674,molecular_function molecular_function;GO:0005179,molecular_function hormone activity;GO:0005184,molecular_function neuropeptide hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0008083,molecular_function growth factor activity;GO:0009409,biological_process response to cold;GO:0019953,biological_process sexual reproduction;GO:0030073,biological_process insulin secretion;GO:0030133,cellular_component transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032868,biological_process response to insulin;GO:0033500,biological_process carbohydrate homeostasis;GO:0042593,biological_process glucose homeostasis;GO:0042742,biological_process defense response to bacterium;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048167,biological_process regulation of synaptic plasticity;GO:0051591,biological_process response to cAMP	NA	VGF nerve growth factor inducible [Source:HGNC Symbol%3BAcc:HGNC:12684]
ENSG00000205436	0.06	0.29	0.16	0.26	0.45	0.45	-1.26619681883512	-0.325379007244509	0.00873579955072229	0.10487183735311	14:103100143-103110559:+	EXOC3L4	4;GO:0000145,cellular_component exocyst;GO:0000149,molecular_function SNARE binding;GO:0006887,biological_process exocytosis;GO:0051601,biological_process exocyst localization	NA	exocyst complex component 3 like 4 [Source:HGNC Symbol%3BAcc:HGNC:20120]
ENSG00000114554	8.23	8.72	8.66	8.10	7.16	7.31	0.193153331660443	5.51702382985733	0.00874457969723379	0.104875814281897	3:126988593-127037392:+	PLXNA1	16;GO:0002116,cellular_component semaphorin receptor complex;GO:0004872,molecular_function receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0014910,biological_process regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0021785,biological_process branchiomotor neuron axon guidance;GO:0048841,biological_process regulation of axon extension involved in axon guidance;GO:0060666,biological_process dichotomous subdivision of terminal units involved in salivary gland branching;GO:0070062,cellular_component extracellular exosome;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0097485,biological_process neuron projection guidance;GO:1990138,biological_process neuron projection extension	PLXNA; plexin A; K06820	plexin A1 [Source:HGNC Symbol%3BAcc:HGNC:9099]
ENSG00000103021	8.74	9.04	8.59	11.85	11.13	9.95	-0.309179313402931	3.50421178247153	0.00878161993101282	0.105218386296971	16:58231156-58283836:+	CCDC113	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0034451,cellular_component centriolar satellite;GO:0043234,cellular_component protein complex;GO:0060271,biological_process cilium morphogenesis	NA	coiled-coil domain containing 113 [Source:HGNC Symbol%3BAcc:HGNC:25002]
ENSG00000152749	9.42	12.52	9.26	7.88	8.62	8.04	0.344681154990238	3.62091945480634	0.00879653626275108	0.105295472159623	13:94601902-94634645:+	GPR180	5;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019236,biological_process response to pheromone;GO:0070062,cellular_component extracellular exosome	NA	G protein-coupled receptor 180 [Source:HGNC Symbol%3BAcc:HGNC:28899]
ENSG00000157456	63.28	66.90	60.08	76.15	73.81	68.26	-0.187759241273782	6.39093895416418	0.00883145093916806	0.105611561182941	15:59105077-59125045:+	CCNB2	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0001701,biological_process in utero embryonic development;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0040007,biological_process growth;GO:0043029,biological_process T cell homeostasis;GO:0045296,molecular_function cadherin binding;GO:0048538,biological_process thymus development;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	CCNB1; G2/mitotic-specific cyclin-B1; K05868	cyclin B2 [Source:HGNC Symbol%3BAcc:HGNC:1580]
ENSG00000131697	5.59	4.83	5.33	4.64	4.60	4.24	0.243407232081906	4.44450405203072	0.00885479334967767	0.105788787150673	1:5862810-5992473:-	NPHP4	32;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0005929,cellular_component cilium;GO:0007165,biological_process signal transduction;GO:0007632,biological_process visual behavior;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030317,biological_process sperm motility;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035329,biological_process hippo signaling;GO:0035845,biological_process photoreceptor cell outer segment organization;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045494,biological_process photoreceptor cell maintenance;GO:0060041,biological_process retina development in camera-type eye;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097470,cellular_component ribbon synapse;GO:0097546,cellular_component ciliary base;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0097730,cellular_component non-motile cilium;GO:1903348,biological_process positive regulation of bicellular tight junction assembly	NA	nephrocystin 4 [Source:HGNC Symbol%3BAcc:HGNC:19104]
ENSG00000057019	162.44	170.22	162.01	143.02	151.62	152.62	0.156835187220521	8.58289952881411	0.0088714958028407	0.105810776100124	3:98795940-98901689:-	DCBLD2	8;GO:0005515,molecular_function protein binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0042060,biological_process wound healing	NA	discoidin%2C CUB and LCCL domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24627]
ENSG00000145779	43.01	40.42	43.88	52.65	46.09	49.27	-0.202680204797095	5.18014672019565	0.00887368851100308	0.105810776100124	5:119268691-119399688:+	TNFAIP8	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	NA	TNF alpha induced protein 8 [Source:HGNC Symbol%3BAcc:HGNC:17260]
ENSG00000032389	9.43	10.43	10.25	12.25	12.61	11.06	-0.245701376071448	4.38835519294368	0.00888220645261652	0.105810776100124	2:3188924-3377882:-	EIPR1	NA	NA	EARP complex and GARP complex interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:12383]
ENSG00000065600	3.44	4.88	4.48	5.65	5.35	6.27	-0.437749146642742	2.66294991991138	0.00893282550225652	0.106180885167881	1:212363930-212414901:-	TMEM206	3;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 206 [Source:HGNC Symbol%3BAcc:HGNC:25593]
ENSG00000126821	23.01	25.57	22.59	20.71	20.81	20.30	0.209182777383672	4.87818944528188	0.00893789007607022	0.106180885167881	14:63684213-63728039:-	SGPP1	14;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006665,biological_process sphingolipid metabolic process;GO:0006668,biological_process sphinganine-1-phosphate metabolic process;GO:0006670,biological_process sphingosine metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0042392,molecular_function sphingosine-1-phosphate phosphatase activity;GO:0070780,molecular_function dihydrosphingosine-1-phosphate phosphatase activity;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097193,biological_process intrinsic apoptotic signaling pathway	SGPP1; sphingosine-1-phosphate phosphatase 1 [EC:3.1.3.-]; K04716	sphingosine-1-phosphate phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:17720]
ENSG00000169710	43.53	56.93	39.57	34.38	44.53	32.82	0.337074403031612	8.30856072034655	0.00893893700156577	0.106180885167881	17:82078332-82098332:-	FASN	53;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004312,molecular_function fatty acid synthase activity;GO:0004313,molecular_function [acyl-carrier-protein] S-acetyltransferase activity;GO:0004314,molecular_function [acyl-carrier-protein] S-malonyltransferase activity;GO:0004315,molecular_function 3-oxoacyl-[acyl-carrier-protein] synthase activity;GO:0004316,molecular_function 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity;GO:0004317,molecular_function 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity;GO:0004319,molecular_function enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity;GO:0004320,molecular_function oleoyl-[acyl-carrier-protein] hydrolase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006084,biological_process acetyl-CoA metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0008144,molecular_function drug binding;GO:0008152,biological_process metabolic process;GO:0009058,biological_process biosynthetic process;GO:0015939,biological_process pantothenate metabolic process;GO:0016020,cellular_component membrane;GO:0016295,molecular_function myristoyl-[acyl-carrier-protein] hydrolase activity;GO:0016296,molecular_function palmitoyl-[acyl-carrier-protein] hydrolase activity;GO:0016297,molecular_function acyl-[acyl-carrier-protein] hydrolase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0016829,molecular_function lyase activity;GO:0019171,molecular_function 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity;GO:0030879,biological_process mammary gland development;GO:0031177,molecular_function phosphopantetheine binding;GO:0031325,biological_process positive regulation of cellular metabolic process;GO:0042470,cellular_component melanosome;GO:0042587,cellular_component glycogen granule;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045296,molecular_function cadherin binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0047117,molecular_function enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity;GO:0047451,molecular_function 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070402,molecular_function NADPH binding;GO:0071353,biological_process cellular response to interleukin-4;GO:0102131,molecular_function 3-oxo-glutaryl-[acp] methyl ester reductase activity;GO:0102132,molecular_function 3-oxo-pimeloyl-[acp] methyl ester reductase activity	FASN; fatty acid synthase, animal type [EC:2.3.1.85]; K00665	fatty acid synthase [Source:HGNC Symbol%3BAcc:HGNC:3594]
ENSG00000134138	11.36	9.40	11.24	8.98	9.15	8.70	0.27604781231383	4.00348897439634	0.00907651531120798	0.107696075279012	15:36889203-37101299:-	MEIS2	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001654,biological_process eye development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0008542,biological_process visual learning;GO:0009612,biological_process response to mechanical stimulus;GO:0031016,biological_process pancreas development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070848,biological_process response to growth factor;GO:0110024,Biological_Process positive regulation of cardiac muscle myoblast proliferation	NA	Meis homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:7001]
ENSG00000168228	8.56	7.74	8.97	11.26	10.08	9.71	-0.277245393960809	3.8770962547953	0.00908384683937207	0.107696075279012	4:25312784-25370383:+	ZCCHC4	7;GO:0003676,molecular_function nucleic acid binding;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 4 [Source:HGNC Symbol%3BAcc:HGNC:22917]
ENSG00000073910	0.22	0.28	0.22	0.44	0.32	0.34	-0.612695271730737	1.55521192017179	0.00916312957839296	0.108466354637873	13:32031299-32299122:+	FRY	12;GO:0000902,biological_process cell morphogenesis;GO:0000922,cellular_component spindle pole;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0030427,cellular_component site of polarized growth;GO:0031175,biological_process neuron projection development;GO:0043086,biological_process negative regulation of catalytic activity;GO:0090527,biological_process actin filament reorganization;GO:1904428,biological_process negative regulation of tubulin deacetylation	NA	FRY microtubule binding protein [Source:HGNC Symbol%3BAcc:HGNC:20367]
ENSG00000187955	5.42	6.28	5.58	6.23	7.78	6.63	-0.248319633662899	5.13531383134302	0.00916629388666151	0.108466354637873	8:120059779-120372036:+	COL14A1	16;GO:0003723,molecular_function RNA binding;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005596,cellular_component collagen type XIV trimer;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0030674,molecular_function protein binding, bridging;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	COL14A; collagen, type XIV, alpha; K08133	collagen type XIV alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2191]
ENSG00000044115	196.45	192.44	195.92	224.54	208.68	222.55	-0.153343649320618	9.23749727116262	0.00918954188082157	0.108540861852597	5:138610966-138935034:+	CTNNA1	55;GO:0001541,biological_process ovarian follicle development;GO:0001669,cellular_component acrosomal vesicle;GO:0003723,molecular_function RNA binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005915,cellular_component zonula adherens;GO:0005925,cellular_component focal adhesion;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007406,biological_process negative regulation of neuroblast proliferation;GO:0007568,biological_process aging;GO:0008013,molecular_function beta-catenin binding;GO:0008584,biological_process male gonad development;GO:0014070,biological_process response to organic cyclic compound;GO:0014704,cellular_component intercalated disc;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016264,biological_process gap junction assembly;GO:0016342,cellular_component catenin complex;GO:0016600,cellular_component flotillin complex;GO:0017166,molecular_function vinculin binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0031103,biological_process axon regeneration;GO:0034332,biological_process adherens junction organization;GO:0034613,biological_process cellular protein localization;GO:0042127,biological_process regulation of cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043297,biological_process apical junction assembly;GO:0043627,biological_process response to estrogen;GO:0045295,molecular_function gamma-catenin binding;GO:0045296,molecular_function cadherin binding;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0046982,molecular_function protein heterodimerization activity;GO:0048854,biological_process brain morphogenesis;GO:0051015,molecular_function actin filament binding;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051291,biological_process protein heterooligomerization;GO:0071681,biological_process cellular response to indole-3-methanol;GO:0090136,biological_process epithelial cell-cell adhesion;GO:2000146,biological_process negative regulation of cell motility;GO:2001045,biological_process negative regulation of integrin-mediated signaling pathway;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	catenin alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:2509]
ENSG00000173083	2.69	2.87	3.21	3.22	4.70	4.23	-0.457589227484957	2.55078945383833	0.00919007861170379	0.108540861852597	4:83292460-83335153:-	HPSE	33;GO:0004566,molecular_function beta-glucuronidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0006029,biological_process proteoglycan metabolic process;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030194,biological_process positive regulation of blood coagulation;GO:0030200,biological_process heparan sulfate proteoglycan catabolic process;GO:0030305,molecular_function heparanase activity;GO:0033690,biological_process positive regulation of osteoblast proliferation;GO:0035580,cellular_component specific granule lumen;GO:0042060,biological_process wound healing;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045121,cellular_component membrane raft;GO:0045545,molecular_function syndecan binding;GO:0046983,molecular_function protein dimerization activity;GO:0051797,biological_process regulation of hair follicle development;GO:0051798,biological_process positive regulation of hair follicle development;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0061042,biological_process vascular wound healing	HPSE; heparanase [EC:3.2.1.166]; K07964	heparanase [Source:HGNC Symbol%3BAcc:HGNC:5164]
ENSG00000008735	1.09	0.89	0.86	0.55	0.74	0.46	0.731284829671471	1.01976296807606	0.00922303438077439	0.108717318381237	22:50600684-50613981:+	MAPK8IP2	25;GO:0001540,molecular_function beta-amyloid binding;GO:0001662,biological_process behavioral fear response;GO:0005078,molecular_function MAP-kinase scaffold activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007172,biological_process signal complex assembly;GO:0007254,biological_process JNK cascade;GO:0007617,biological_process mating behavior;GO:0010469,biological_process regulation of receptor activity;GO:0014069,cellular_component postsynaptic density;GO:0019894,molecular_function kinesin binding;GO:0019901,molecular_function protein kinase binding;GO:0032403,molecular_function protein complex binding;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0035176,biological_process social behavior;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0046328,biological_process regulation of JNK cascade;GO:0046958,biological_process nonassociative learning;GO:0048813,biological_process dendrite morphogenesis;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060079,biological_process excitatory postsynaptic potential;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	MAPK8IP2, JIP2; mitogen-activated protein kinase 8 interacting protein 2; K04435	mitogen-activated protein kinase 8 interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6883]
ENSG00000182362	11.42	11.25	11.02	7.02	9.84	8.00	0.450819449529432	2.32788524011496	0.00922567458085459	0.108717318381237	21:46286336-46297751:+	YBEY	6;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006364,biological_process rRNA processing;GO:0006508,biological_process proteolysis;GO:0046872,molecular_function metal ion binding	NA	ybeY metallopeptidase (putative) [Source:HGNC Symbol%3BAcc:HGNC:1299]
ENSG00000066322	110.20	121.26	113.70	102.69	104.29	101.49	0.171958261411716	6.51266410485048	0.00923129409279172	0.108717318381237	1:43363396-43368074:-	ELOVL1	22;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0009922,molecular_function fatty acid elongase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0019367,biological_process fatty acid elongation, saturated fatty acid;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034625,biological_process fatty acid elongation, monounsaturated fatty acid;GO:0034626,biological_process fatty acid elongation, polyunsaturated fatty acid;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0043651,biological_process linoleic acid metabolic process;GO:0102336,molecular_function 3-oxo-arachidoyl-CoA synthase activity;GO:0102337,molecular_function 3-oxo-cerotoyl-CoA synthase activity;GO:0102338,molecular_function 3-oxo-lignoceronyl-CoA synthase activity	ELOVL1; elongation of very long chain fatty acids protein 1 [EC:2.3.1.199]; K10247	ELOVL fatty acid elongase 1 [Source:HGNC Symbol%3BAcc:HGNC:14418]
ENSG00000112576	11.85	11.56	8.54	8.69	7.77	8.23	0.378685224480003	3.29042719394072	0.0092805393268706	0.109193682146393	6:41934932-42050357:-	CCND3	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0042098,biological_process T cell proliferation;GO:0042127,biological_process regulation of cell proliferation;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	CCND3; G1/S-specific cyclin-D3; K10152	cyclin D3 [Source:HGNC Symbol%3BAcc:HGNC:1585]
ENSG00000163703	32.87	29.05	28.56	26.01	26.04	27.53	0.199167104704871	5.39093203802581	0.00931128824378205	0.109451724403472	3:9933821-9945413:+	CRELD1	5;GO:0003197,biological_process endocardial cushion development;GO:0003279,biological_process cardiac septum development;GO:0005509,molecular_function calcium ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	cysteine rich with EGF like domains 1 [Source:HGNC Symbol%3BAcc:HGNC:14630]
ENSG00000167632	13.05	12.25	11.21	10.67	10.83	10.64	0.196047486906387	5.43224699180159	0.00932542618228991	0.109514205487951	8:139730342-140458579:-	TRAPPC9	16;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0021987,biological_process cerebral cortex development;GO:0030008,cellular_component TRAPP complex;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048208,biological_process COPII vesicle coating;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 9 [Source:HGNC Symbol%3BAcc:HGNC:30832]
ENSG00000197948	13.52	12.91	14.79	12.44	12.20	11.04	0.224809624888384	4.88567284097628	0.00935599925829143	0.109684525220155	5:141639301-141651419:-	FCHSD1	4;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0030833,biological_process regulation of actin filament polymerization;GO:0031594,cellular_component neuromuscular junction;GO:0055037,cellular_component recycling endosome	NA	FCH and double SH3 domains 1 [Source:HGNC Symbol%3BAcc:HGNC:25463]
ENSG00000144481	9.97	10.56	10.16	12.05	12.42	10.97	-0.197619072781988	5.32502485747988	0.00935760188577653	0.109684525220155	2:233917397-234019522:+	TRPM8	27;GO:0005216,molecular_function ion channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0009266,biological_process response to temperature stimulus;GO:0009409,biological_process response to cold;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016048,biological_process detection of temperature stimulus;GO:0034220,biological_process ion transmembrane transport;GO:0042803,molecular_function protein homodimerization activity;GO:0045121,cellular_component membrane raft;GO:0050896,biological_process response to stimulus;GO:0050951,biological_process sensory perception of temperature stimulus;GO:0050955,biological_process thermoception;GO:0051289,biological_process protein homotetramerization;GO:0055085,biological_process transmembrane transport;GO:0070207,biological_process protein homotrimerization;GO:0070588,biological_process calcium ion transmembrane transport	TRPM8; transient receptor potential cation channel subfamily M member 8; K04983	transient receptor potential cation channel subfamily M member 8 [Source:HGNC Symbol%3BAcc:HGNC:17961]
ENSG00000107957	4.63	5.29	4.83	3.83	4.57	3.74	0.286748024114522	3.93759698177814	0.00938914374413499	0.109950416316932	10:103594026-103855543:-	SH3PXD2A	15;GO:0002102,cellular_component podosome;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006801,biological_process superoxide metabolic process;GO:0016176,molecular_function superoxide-generating NADPH oxidase activator activity;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042995,cellular_component cell projection;GO:0043085,biological_process positive regulation of catalytic activity;GO:0055114,biological_process oxidation-reduction process;GO:0071800,biological_process podosome assembly;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0072675,biological_process osteoclast fusion	NA	SH3 and PX domains 2A [Source:HGNC Symbol%3BAcc:HGNC:23664]
ENSG00000171552	113.67	106.09	106.66	130.25	116.20	125.75	-0.176662876742277	6.35139807799787	0.00942655489915201	0.11028447310384	20:31664451-31723989:-	BCL2L1	71;GO:0000910,biological_process cytokinesis;GO:0001541,biological_process ovarian follicle development;GO:0001701,biological_process in utero embryonic development;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007281,biological_process germ cell development;GO:0007283,biological_process spermatogenesis;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009314,biological_process response to radiation;GO:0009566,biological_process fertilization;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019050,biological_process suppression by virus of host apoptotic process;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031965,cellular_component nuclear membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0034097,biological_process response to cytokine;GO:0040007,biological_process growth;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045202,cellular_component synapse;GO:0046898,biological_process response to cycloheximide;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0046982,molecular_function protein heterodimerization activity;GO:0051402,biological_process neuron apoptotic process;GO:0051434,molecular_function BH3 domain binding;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0060154,biological_process cellular process regulating host cell cycle in response to virus;GO:0070584,biological_process mitochondrion morphogenesis;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071312,biological_process cellular response to alkaloid;GO:0071480,biological_process cellular response to gamma radiation;GO:0071839,biological_process apoptotic process in bone marrow;GO:0090005,biological_process negative regulation of establishment of protein localization to plasma membrane;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097136,cellular_component Bcl-2 family protein complex;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097284,biological_process hepatocyte apoptotic process;GO:1900118,biological_process negative regulation of execution phase of apoptosis;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X); K04570	BCL2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:992]
ENSG00000138641	3.90	4.35	4.41	3.31	3.43	3.69	0.286666248239853	3.63009032979379	0.00947176087888685	0.1107090092181	4:88521047-88708542:+	HERC3	7;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0061630,molecular_function ubiquitin protein ligase activity	HERC3; E3 ubiquitin-protein ligase HERC3 [EC:2.3.2.26]; K10614	HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Source:HGNC Symbol%3BAcc:HGNC:4876]
ENSG00000125347	59.33	40.58	61.75	74.41	56.86	76.45	-0.34654496239149	5.91814258378404	0.00949441784857657	0.110869434387941	5:132481608-132490798:-	IRF1	41;GO:0000790,cellular_component nuclear chromatin;GO:0000975,molecular_function regulatory region DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002376,biological_process immune system process;GO:0002819,biological_process regulation of adaptive immune response;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007050,biological_process cell cycle arrest;GO:0007596,biological_process blood coagulation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0034124,biological_process regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0035458,biological_process cellular response to interferon-beta;GO:0043374,biological_process CD8-positive, alpha-beta T cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045084,biological_process positive regulation of interleukin-12 biosynthetic process;GO:0045087,biological_process innate immune response;GO:0045088,biological_process regulation of innate immune response;GO:0045590,biological_process negative regulation of regulatory T cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050776,biological_process regulation of immune response;GO:0051607,biological_process defense response to virus;GO:0051726,biological_process regulation of cell cycle;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0071260,biological_process cellular response to mechanical stimulus;GO:2000564,biological_process regulation of CD8-positive, alpha-beta T cell proliferation	IRF1; interferon regulatory factor 1; K09444	interferon regulatory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:6116]
ENSG00000126500	0.80	0.57	0.62	1.67	0.79	1.08	-0.79692010166574	1.02691989768313	0.00952759247176254	0.111152260669162	11:64103187-64119173:+	FLRT1	32;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005104,molecular_function fibroblast growth factor receptor binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016358,biological_process dendrite development;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030674,molecular_function protein binding, bridging;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032809,cellular_component neuronal cell body membrane;GO:0042995,cellular_component cell projection;GO:0044306,cellular_component neuron projection terminus;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051965,biological_process positive regulation of synapse assembly;GO:1990138,biological_process neuron projection extension	NA	fibronectin leucine rich transmembrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3760]
ENSG00000011258	8.68	7.80	8.59	10.05	11.20	9.22	-0.263084129107158	4.18082736386978	0.0095402828169371	0.111157010465267	17:51177424-51260163:-	MBTD1	8;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0035064,molecular_function methylated histone binding;GO:0046872,molecular_function metal ion binding;GO:0048706,biological_process embryonic skeletal system development	NA	mbt domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19866]
ENSG00000105404	174.21	185.10	170.68	147.32	164.94	159.26	0.178945250759477	6.53565697083672	0.0095459093817751	0.111157010465267	19:41956680-41959390:-	RABAC1	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0008021,cellular_component synaptic vesicle;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042802,molecular_function identical protein binding;GO:0045202,cellular_component synapse;GO:0070064,molecular_function proline-rich region binding	NA	Rab acceptor 1 [Source:HGNC Symbol%3BAcc:HGNC:9794]
ENSG00000214491	84.26	83.13	78.30	90.97	93.93	92.93	-0.16598382184537	6.70251534890415	0.00957320398460428	0.111370366505054	22:30522798-30546682:-	SEC14L6	4;GO:0005215,molecular_function transporter activity;GO:0005622,cellular_component intracellular;GO:0006810,biological_process transport;GO:0016021,cellular_component integral component of membrane	NA	SEC14 like lipid binding 6 [Source:HGNC Symbol%3BAcc:HGNC:40047]
ENSG00000108846	168.47	156.04	187.74	154.93	143.72	154.01	0.190376479749774	9.68760780979352	0.00958970934165447	0.111457923275241	17:50634776-50692252:+	ABCC3	21;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0008559,molecular_function xenobiotic-transporting ATPase activity;GO:0015432,molecular_function bile acid-exporting ATPase activity;GO:0015721,biological_process bile acid and bile salt transport;GO:0015722,biological_process canalicular bile acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016887,molecular_function ATPase activity;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042908,biological_process xenobiotic transport;GO:0043225,molecular_function anion transmembrane-transporting ATPase activity;GO:0055085,biological_process transmembrane transport;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport	ABCC3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3; K05667	ATP binding cassette subfamily C member 3 [Source:HGNC Symbol%3BAcc:HGNC:54]
ENSG00000108883	47.56	47.44	46.97	53.85	51.49	54.25	-0.157085443177974	7.2141573756032	0.00962575887135592	0.111772258999196	17:44849942-44899662:-	EFTUD2	20;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0031012,cellular_component extracellular matrix;GO:0035690,biological_process cellular response to drug;GO:0042220,biological_process response to cocaine;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071013,cellular_component catalytic step 2 spliceosome	EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component; K12852	elongation factor Tu GTP binding domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30858]
ENSG00000147383	27.71	34.84	25.91	22.41	26.70	23.88	0.282540092036891	4.9122739747037	0.00963965208766375	0.111828973237542	X:152830966-152869729:+	NSDHL	21;GO:0000252,molecular_function C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity;GO:0001942,biological_process hair follicle development;GO:0003854,molecular_function 3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0007224,biological_process smoothened signaling pathway;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0047012,molecular_function sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity;GO:0055114,biological_process oxidation-reduction process;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0103066,molecular_function 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity	NSDHL, ERG26; sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170]; K07748	NAD(P) dependent steroid dehydrogenase-like [Source:HGNC Symbol%3BAcc:HGNC:13398]
ENSG00000138069	300.65	338.13	300.51	268.08	290.79	277.16	0.178620869278208	7.50890827900468	0.00966444686789116	0.111968731891272	2:65070700-65130106:-	RAB1A	40;GO:0000045,biological_process autophagosome assembly;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0007030,biological_process Golgi organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016477,biological_process cell migration;GO:0019068,biological_process virion assembly;GO:0030252,biological_process growth hormone secretion;GO:0030658,cellular_component transport vesicle membrane;GO:0032402,biological_process melanosome transport;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042470,cellular_component melanosome;GO:0042742,biological_process defense response to bacterium;GO:0043687,biological_process post-translational protein modification;GO:0045296,molecular_function cadherin binding;GO:0047496,biological_process vesicle transport along microtubule;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072606,biological_process interleukin-8 secretion;GO:0090110,biological_process cargo loading into COPII-coated vesicle;GO:1903020,biological_process positive regulation of glycoprotein metabolic process;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	RAB1A; Ras-related protein Rab-1A; K07874	RAB1A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9758]
ENSG00000140386	3.42	3.46	3.34	2.94	2.64	2.97	0.264589356427168	3.80468689852229	0.00966973983625581	0.111968731891272	15:76347903-76905444:-	SCAPER	6;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	S-phase cyclin A associated protein in the ER [Source:HGNC Symbol%3BAcc:HGNC:13081]
ENSG00000102312	31.84	22.57	31.50	44.83	27.64	41.66	-0.395456947672228	5.72597141671226	0.00968297514255563	0.112017493424551	X:48508961-48520814:+	PORCN	15;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006497,biological_process protein lipidation;GO:0009100,biological_process glycoprotein metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017147,molecular_function Wnt-protein binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0045234,biological_process protein palmitoleylation;GO:0060070,biological_process canonical Wnt signaling pathway;GO:1990698,molecular_function palmitoleoyltransferase activity	PORCN; O-palmitoleoyl transferase [EC:2.3.1.250]; K00181	porcupine O-acyltransferase [Source:HGNC Symbol%3BAcc:HGNC:17652]
ENSG00000134884	112.34	110.39	108.01	93.40	94.26	106.64	0.17966053204327	6.51650595149443	0.00969539100319914	0.112056693224126	13:106541672-106568164:-	ARGLU1	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045296,molecular_function cadherin binding	NA	arginine and glutamate rich 1 [Source:HGNC Symbol%3BAcc:HGNC:25482]
ENSG00000213762	13.42	11.78	12.92	16.29	13.64	16.16	-0.257670923075263	4.2921334517952	0.00971046777370774	0.112126545558171	19:57614232-57624723:+	ZNF134	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 134 [Source:HGNC Symbol%3BAcc:HGNC:12918]
ENSG00000095637	14.17	12.92	14.79	12.97	12.16	12.14	0.182942574234868	6.25480079455813	0.00971970469637562	0.112128898137649	10:95311770-95561414:-	SORBS1	36;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005899,cellular_component insulin receptor complex;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005915,cellular_component zonula adherens;GO:0005924,cellular_component cell-substrate adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006936,biological_process muscle contraction;GO:0007015,biological_process actin filament organization;GO:0007160,biological_process cell-matrix adhesion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009967,biological_process positive regulation of signal transduction;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0030054,cellular_component cell junction;GO:0032869,biological_process cellular response to insulin stimulus;GO:0043149,biological_process stress fiber assembly;GO:0045121,cellular_component membrane raft;GO:0045725,biological_process positive regulation of glycogen biosynthetic process;GO:0046326,biological_process positive regulation of glucose import;GO:0046889,biological_process positive regulation of lipid biosynthetic process;GO:0048041,biological_process focal adhesion assembly;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane	SORBS1, SH3D5, PONSIN, CAP; sorbin and SH3 domain containing 1; K06086	sorbin and SH3 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14565]
ENSG00000103657	3.33	3.45	3.27	3.03	2.99	2.96	0.17184311016287	5.54328873168021	0.00982555956809256	0.113230679698032	15:63608617-63833942:-	HERC1	15;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0010507,biological_process negative regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0021702,biological_process cerebellar Purkinje cell differentiation;GO:0031175,biological_process neuron projection development;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050885,biological_process neuromuscular process controlling balance	HERC1; E3 ubiquitin-protein ligase HERC1 [EC:2.3.2.26]; K10594	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [Source:HGNC Symbol%3BAcc:HGNC:4867]
ENSG00000100596	20.73	20.73	19.33	24.45	22.43	22.96	-0.189618031284118	5.31220755355493	0.00983345466160307	0.113230679698032	14:77505996-77616773:-	SPTLC2	21;GO:0003824,molecular_function catalytic activity;GO:0004758,molecular_function serine C-palmitoyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006686,biological_process sphingomyelin biosynthetic process;GO:0008152,biological_process metabolic process;GO:0009058,biological_process biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017059,cellular_component serine C-palmitoyltransferase complex;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0046511,biological_process sphinganine biosynthetic process;GO:0046512,biological_process sphingosine biosynthetic process;GO:0046513,biological_process ceramide biosynthetic process;GO:1904504,biological_process positive regulation of lipophagy	SPT; serine palmitoyltransferase [EC:2.3.1.50]; K00654	serine palmitoyltransferase long chain base subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:11278]
ENSG00000185504	7.99	8.13	9.10	7.32	6.89	7.53	0.226654177099324	4.62744477853578	0.00989455393591531	0.113828635779904	17:81539884-81553961:-	FAAP100	10;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0045111,cellular_component intermediate filament cytoskeleton	FAAP100; fanconi anemia core complex 100 kDa subunit; K10993	Fanconi anemia core complex associated protein 100 [Source:HGNC Symbol%3BAcc:HGNC:26171]
ENSG00000065485	55.36	55.16	56.85	52.07	48.65	49.80	0.165179956830089	6.38420840540058	0.00992371693296137	0.114058424341527	3:123067061-123225227:+	PDIA5	14;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0015037,molecular_function peptide disulfide oxidoreductase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016853,molecular_function isomerase activity;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process	NA	protein disulfide isomerase family A member 5 [Source:HGNC Symbol%3BAcc:HGNC:24811]
ENSG00000153044	16.68	19.22	15.00	20.71	19.24	23.34	-0.314198583681384	3.83390804200161	0.00996041001650875	0.114287229597388	5:69189547-69210357:+	CENPH	14;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0043515,molecular_function kinetochore binding;GO:0051382,biological_process kinetochore assembly;GO:0051383,biological_process kinetochore organization	NA	centromere protein H [Source:HGNC Symbol%3BAcc:HGNC:17268]
ENSG00000163811	25.52	23.62	26.78	29.23	30.06	27.73	-0.181249116398406	5.79224249617687	0.00996203838108227	0.114287229597388	2:28894642-28948222:+	WDR43	12;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0042254,biological_process ribosome biogenesis;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:2000234,biological_process positive regulation of rRNA processing	UTP5, WDR43; U3 small nucleolar RNA-associated protein 5; K14546	WD repeat domain 43 [Source:HGNC Symbol%3BAcc:HGNC:28945]
ENSG00000136875	23.99	24.78	22.47	27.30	26.93	27.21	-0.184418955361984	5.32291258671674	0.00998122397064273	0.114401600320949	9:113275342-113292905:+	PRPF4	16;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0017070,molecular_function U6 snRNA binding;GO:0030621,molecular_function U4 snRNA binding;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071001,cellular_component U4/U6 snRNP;GO:0097525,cellular_component spliceosomal snRNP complex	PRPF4, PRP4; U4/U6 small nuclear ribonucleoprotein PRP4; K12662	pre-mRNA processing factor 4 [Source:HGNC Symbol%3BAcc:HGNC:17349]
ENSG00000114251	4.63	4.68	4.38	3.80	3.25	3.14	0.436856984762643	2.22612895396605	0.0100217154719945	0.114759736304306	3:55465714-55490539:-	WNT5A	192;GO:0000187,biological_process activation of MAPK activity;GO:0001667,biological_process ameboidal-type cell migration;GO:0001736,biological_process establishment of planar polarity;GO:0001756,biological_process somitogenesis;GO:0001819,biological_process positive regulation of cytokine production;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001843,biological_process neural tube closure;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001947,biological_process heart looping;GO:0002009,biological_process morphogenesis of an epithelium;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002088,biological_process lens development in camera-type eye;GO:0002741,biological_process positive regulation of cytokine secretion involved in immune response;GO:0003323,biological_process type B pancreatic cell development;GO:0003344,biological_process pericardium morphogenesis;GO:0003401,biological_process axis elongation;GO:0003402,biological_process planar cell polarity pathway involved in axis elongation;GO:0003408,biological_process optic cup formation involved in camera-type eye development;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005110,molecular_function frizzled-2 binding;GO:0005115,molecular_function receptor tyrosine kinase-like orphan receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007254,biological_process JNK cascade;GO:0007257,biological_process activation of JUN kinase activity;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0007442,biological_process hindgut morphogenesis;GO:0007494,biological_process midgut development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0008595,biological_process anterior/posterior axis specification, embryo;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010820,biological_process positive regulation of T cell chemotaxis;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016055,biological_process Wnt signaling pathway;GO:0016477,biological_process cell migration;GO:0019904,molecular_function protein domain specific binding;GO:0021891,biological_process olfactory bulb interneuron development;GO:0021915,biological_process neural tube development;GO:0022008,biological_process neurogenesis;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030324,biological_process lung development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0030825,biological_process positive regulation of cGMP metabolic process;GO:0030901,biological_process midbrain development;GO:0032092,biological_process positive regulation of protein binding;GO:0032148,biological_process activation of protein kinase B activity;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032880,biological_process regulation of protein localization;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034613,biological_process cellular protein localization;GO:0035108,biological_process limb morphogenesis;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0036342,biological_process post-anal tail morphogenesis;GO:0036517,biological_process chemoattraction of serotonergic neuron axon;GO:0036518,biological_process chemorepulsion of dopaminergic neuron axon;GO:0038031,biological_process non-canonical Wnt signaling pathway via JNK cascade;GO:0040037,biological_process negative regulation of fibroblast growth factor receptor signaling pathway;GO:0042060,biological_process wound healing;GO:0042472,biological_process inner ear morphogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043032,biological_process positive regulation of macrophage activation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045080,biological_process positive regulation of chemokine biosynthetic process;GO:0045165,biological_process cell fate commitment;GO:0045198,biological_process establishment of epithelial cell apical/basal polarity;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045778,biological_process positive regulation of ossification;GO:0045807,biological_process positive regulation of endocytosis;GO:0045836,biological_process positive regulation of meiotic nuclear division;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046546,biological_process development of primary male sexual characteristics;GO:0048018,molecular_function receptor agonist activity;GO:0048022,biological_process negative regulation of melanin biosynthetic process;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048341,biological_process paraxial mesoderm formation;GO:0048546,biological_process digestive tract morphogenesis;GO:0048570,biological_process notochord morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0048806,biological_process genitalia development;GO:0048812,biological_process neuron projection morphogenesis;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0048850,biological_process hypophysis morphogenesis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050919,biological_process negative chemotaxis;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051216,biological_process cartilage development;GO:0051885,biological_process positive regulation of anagen;GO:0051964,biological_process negative regulation of synapse assembly;GO:0060021,biological_process palate development;GO:0060026,biological_process convergent extension;GO:0060028,biological_process convergent extension involved in axis elongation;GO:0060029,biological_process convergent extension involved in organogenesis;GO:0060065,biological_process uterus development;GO:0060067,biological_process cervix development;GO:0060068,biological_process vagina development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060157,biological_process urinary bladder development;GO:0060324,biological_process face development;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway;GO:0060599,biological_process lateral sprouting involved in mammary gland duct morphogenesis;GO:0060606,biological_process tube closure;GO:0060638,biological_process mesenchymal-epithelial cell signaling;GO:0060686,biological_process negative regulation of prostatic bud formation;GO:0060744,biological_process mammary gland branching involved in thelarche;GO:0060750,biological_process epithelial cell proliferation involved in mammary gland duct elongation;GO:0060760,biological_process positive regulation of response to cytokine stimulus;GO:0060762,biological_process regulation of branching involved in mammary gland duct morphogenesis;GO:0060775,biological_process planar cell polarity pathway involved in gastrula mediolateral intercalation;GO:0060809,biological_process mesodermal to mesenchymal transition involved in gastrulation;GO:0060907,biological_process positive regulation of macrophage cytokine production;GO:0061024,biological_process membrane organization;GO:0061036,biological_process positive regulation of cartilage development;GO:0061053,biological_process somite development;GO:0061347,biological_process planar cell polarity pathway involved in outflow tract morphogenesis;GO:0061348,biological_process planar cell polarity pathway involved in ventricular septum morphogenesis;GO:0061349,biological_process planar cell polarity pathway involved in cardiac right atrium morphogenesis;GO:0061350,biological_process planar cell polarity pathway involved in cardiac muscle tissue morphogenesis;GO:0061354,biological_process planar cell polarity pathway involved in pericardium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070245,biological_process positive regulation of thymocyte apoptotic process;GO:0071219,biological_process cellular response to molecule of bacterial origin;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071277,biological_process cellular response to calcium ion;GO:0071300,biological_process cellular response to retinoic acid;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:0071542,biological_process dopaminergic neuron differentiation;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0072201,biological_process negative regulation of mesenchymal cell proliferation;GO:0090009,biological_process primitive streak formation;GO:0090037,biological_process positive regulation of protein kinase C signaling;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090103,biological_process cochlea morphogenesis;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0090630,biological_process activation of GTPase activity;GO:0097325,biological_process melanocyte proliferation;GO:0099054,biological_process presynapse assembly;GO:0099068,biological_process postsynapse assembly;GO:1900020,biological_process positive regulation of protein kinase C activity;GO:1902379,molecular_function chemoattractant activity involved in axon guidance;GO:1902474,biological_process positive regulation of protein localization to synapse;GO:1903827,biological_process regulation of cellular protein localization;GO:1904861,biological_process excitatory synapse assembly;GO:1904862,biological_process inhibitory synapse assembly;GO:1904934,biological_process negative regulation of cell proliferation in midbrain;GO:1904938,biological_process planar cell polarity pathway involved in axon guidance;GO:1904948,biological_process midbrain dopaminergic neuron differentiation;GO:1904953,biological_process Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;GO:1904955,biological_process planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation;GO:2000049,biological_process positive regulation of cell-cell adhesion mediated by cadherin;GO:2000052,biological_process positive regulation of non-canonical Wnt signaling pathway;GO:2000484,biological_process positive regulation of interleukin-8 secretion	WNT5; wingless-type MMTV integration site family, member 5; K00444	Wnt family member 5A [Source:HGNC Symbol%3BAcc:HGNC:12784]
ENSG00000153896	2.65	2.42	2.88	1.86	1.84	2.13	0.464158919265748	2.11094292516985	0.0100757182280874	0.115271788355068	19:34758075-34773229:-	ZNF599	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 599 [Source:HGNC Symbol%3BAcc:HGNC:26408]
ENSG00000185585	22.69	24.77	24.87	21.41	22.07	20.57	0.185635066842207	5.49781966333136	0.010116047833083	0.115626613031362	9:124777157-124814885:+	OLFML2A	5;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0030198,biological_process extracellular matrix organization;GO:0042803,molecular_function protein homodimerization activity;GO:0050840,molecular_function extracellular matrix binding	NA	olfactomedin like 2A [Source:HGNC Symbol%3BAcc:HGNC:27270]
ENSG00000112290	21.94	21.83	22.56	24.60	25.28	25.70	-0.176276336001169	5.31751609728477	0.010189955001929	0.116344673699602	6:110099818-110180004:-	WASF1	26;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006461,biological_process protein complex assembly;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006928,biological_process movement of cell or subcellular component;GO:0015629,cellular_component actin cytoskeleton;GO:0016601,biological_process Rac protein signal transduction;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030041,biological_process actin filament polymerization;GO:0030054,cellular_component cell junction;GO:0031175,biological_process neuron projection development;GO:0031209,cellular_component SCAR complex;GO:0032403,molecular_function protein complex binding;GO:0045202,cellular_component synapse;GO:0048365,molecular_function Rac GTPase binding;GO:0051388,biological_process positive regulation of neurotrophin TRK receptor signaling pathway;GO:0072673,biological_process lamellipodium morphogenesis;GO:0097484,biological_process dendrite extension;GO:1990416,biological_process cellular response to brain-derived neurotrophic factor stimulus;GO:2000601,biological_process positive regulation of Arp2/3 complex-mediated actin nucleation	WASF1; WAS protein family, member 1; K05753	WAS protein family member 1 [Source:HGNC Symbol%3BAcc:HGNC:12732]
ENSG00000183397	12.95	16.16	14.09	11.70	9.80	12.11	0.360054659919591	3.02220584192028	0.0101976158048149	0.116344673699602	19:3539153-3544030:+	C19orf71	NA	NA	chromosome 19 open reading frame 71 [Source:HGNC Symbol%3BAcc:HGNC:34496]
ENSG00000151353	30.33	30.82	28.76	35.64	33.04	37.61	-0.233282041628504	4.41150042397492	0.0102436923602158	0.116715033103515	2:667334-677439:-	TMEM18	8;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0031965,cellular_component nuclear membrane	NA	transmembrane protein 18 [Source:HGNC Symbol%3BAcc:HGNC:25257]
ENSG00000179832	15.12	14.95	17.05	14.04	13.92	14.05	0.178749452881915	6.25153871854042	0.0102488831130936	0.116715033103515	8:144148015-144261940:+	MROH1	NA	NA	maestro heat like repeat family member 1 [Source:HGNC Symbol%3BAcc:HGNC:26958]
ENSG00000135932	65.05	55.98	62.40	75.02	64.52	72.96	-0.197596466237523	6.10430586302504	0.0103298924261954	0.117529747650195	2:230712844-230821075:+	CAB39	28;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007050,biological_process cell cycle arrest;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019900,molecular_function kinase binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030295,molecular_function protein kinase activator activity;GO:0032147,biological_process activation of protein kinase activity;GO:0034774,cellular_component secretory granule lumen;GO:0035556,biological_process intracellular signal transduction;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0051291,biological_process protein heterooligomerization;GO:0070062,cellular_component extracellular exosome;GO:0071476,biological_process cellular hypotonic response;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:1901017,biological_process negative regulation of potassium ion transmembrane transporter activity;GO:1901380,biological_process negative regulation of potassium ion transmembrane transport;GO:1902554,cellular_component serine/threonine protein kinase complex;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2000681,biological_process negative regulation of rubidium ion transport;GO:2000687,biological_process negative regulation of rubidium ion transmembrane transporter activity	NA	calcium binding protein 39 [Source:HGNC Symbol%3BAcc:HGNC:20292]
ENSG00000196526	2.14	1.58	2.23	1.45	1.46	1.44	0.483041256699668	2.18026664549761	0.0103529560970007	0.117684289406657	4:7758713-7939926:-	AFAP1	8;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0009966,biological_process regulation of signal transduction;GO:0015629,cellular_component actin cytoskeleton;GO:0051493,biological_process regulation of cytoskeleton organization	NA	actin filament associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24017]
ENSG00000197249	287.35	229.45	307.47	247.25	207.77	242.81	0.252500314623099	8.33084633513296	0.0103886438975286	0.117981918298282	14:94376746-94390693:-	SERPINA1	29;GO:0000139,cellular_component Golgi membrane;GO:0002020,molecular_function protease binding;GO:0002576,biological_process platelet degranulation;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006953,biological_process acute-phase response;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031093,cellular_component platelet alpha granule lumen;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048208,biological_process COPII vesicle coating;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	SERPINA1, AAT; alpha-1-antitrypsin; K03984	serpin family A member 1 [Source:HGNC Symbol%3BAcc:HGNC:8941]
ENSG00000066248	2.21	2.05	2.60	3.08	2.74	3.36	-0.402872734185856	2.62850742690804	0.0104413542046632	0.118375076130578	2:232878685-233013272:-	NGEF	17;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0030426,cellular_component growth cone;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0061002,biological_process negative regulation of dendritic spine morphogenesis	NGEF, EPHEXIN, ARHGEF27; neuronal guanine nucleotide exchange factor; K07525	neuronal guanine nucleotide exchange factor [Source:HGNC Symbol%3BAcc:HGNC:7807]
ENSG00000168785	46.67	44.95	43.00	40.35	36.38	41.57	0.19737946081594	5.18777064654043	0.010442701850261	0.118375076130578	4:98470366-98658629:-	TSPAN5	8;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0051604,biological_process protein maturation;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	tetraspanin 5 [Source:HGNC Symbol%3BAcc:HGNC:17753]
ENSG00000024526	21.71	23.91	20.62	24.84	29.86	23.70	-0.233275874957786	5.89711914587937	0.0104518717021762	0.118375076130578	1:68474151-68497221:-	DEPDC1	10;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0017053,cellular_component transcriptional repressor complex;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	DEP domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:22949]
ENSG00000164284	14.58	14.73	12.43	16.96	15.96	19.23	-0.315505558882507	3.56754810909018	0.0104723995287373	0.118499448815147	5:149345429-149354583:+	GRPEL2	11;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0001405,cellular_component presequence translocase-associated import motor;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006457,biological_process protein folding;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0042803,molecular_function protein homodimerization activity;GO:0050790,biological_process regulation of catalytic activity;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding	NA	GrpE like 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:21060]
ENSG00000196968	11.25	11.57	8.95	8.39	8.94	8.73	0.291494321261551	3.92835983845469	0.0104913706513222	0.118605996261259	10:73772290-73780251:+	FUT11	13;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008417,molecular_function fucosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0032580,cellular_component Golgi cisterna membrane;GO:0036065,biological_process fucosylation;GO:0046920,molecular_function alpha-(1->3)-fucosyltransferase activity;GO:0070062,cellular_component extracellular exosome	NA	fucosyltransferase 11 [Source:HGNC Symbol%3BAcc:HGNC:19233]
ENSG00000176871	37.74	39.48	35.64	32.15	34.79	33.12	0.182793851032917	5.52554594113584	0.0105029730940607	0.118627113949451	12:118032693-118062430:-	WSB2	5;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	WD repeat and SOCS box containing 2 [Source:HGNC Symbol%3BAcc:HGNC:19222]
ENSG00000101844	3.96	4.17	3.33	1.97	3.31	2.72	0.521914044628055	2.02094961977429	0.010512351997454	0.118627113949451	X:108091667-108154671:+	ATG4A	17;GO:0000045,biological_process autophagosome assembly;GO:0000422,biological_process mitophagy;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006501,biological_process C-terminal protein lipidation;GO:0006508,biological_process proteolysis;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0015031,biological_process protein transport;GO:0016787,molecular_function hydrolase activity;GO:0044804,biological_process nucleophagy;GO:0051697,biological_process protein delipidation	ATG4; cysteine protease ATG4 [EC:3.4.22.-]; K08342	autophagy related 4A cysteine peptidase [Source:HGNC Symbol%3BAcc:HGNC:16489]
ENSG00000109062	48.86	61.57	45.92	42.39	47.60	41.51	0.257239515521262	5.68654217873055	0.0105424744386517	0.118858978389631	17:74748651-74769353:+	SLC9A3R1	73;GO:0001726,cellular_component ruffle;GO:0003096,biological_process renal sodium ion transport;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006461,biological_process protein complex assembly;GO:0007191,biological_process adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007605,biological_process sensory perception of sound;GO:0008013,molecular_function beta-catenin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0008361,biological_process regulation of cell size;GO:0010642,biological_process negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010766,biological_process negative regulation of sodium ion transport;GO:0012505,cellular_component endomembrane system;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016324,cellular_component apical plasma membrane;GO:0017081,molecular_function chloride channel regulator activity;GO:0019902,molecular_function phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0019933,biological_process cAMP-mediated signaling;GO:0022612,biological_process gland morphogenesis;GO:0030033,biological_process microvillus assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030165,molecular_function PDZ domain binding;GO:0030175,cellular_component filopodium;GO:0030336,biological_process negative regulation of cell migration;GO:0030643,biological_process cellular phosphate ion homeostasis;GO:0031526,cellular_component brush border membrane;GO:0031528,cellular_component microvillus membrane;GO:0031698,molecular_function beta-2 adrenergic receptor binding;GO:0031982,cellular_component vesicle;GO:0032403,molecular_function protein complex binding;GO:0032415,biological_process regulation of sodium:proton antiporter activity;GO:0032416,biological_process negative regulation of sodium:proton antiporter activity;GO:0032420,cellular_component stereocilium;GO:0032426,cellular_component stereocilium tip;GO:0032782,biological_process bile acid secretion;GO:0032947,molecular_function protein complex scaffold;GO:0034613,biological_process cellular protein localization;GO:0034635,biological_process glutathione transport;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0040023,biological_process establishment of nucleus localization;GO:0042995,cellular_component cell projection;GO:0043621,molecular_function protein self-association;GO:0044062,biological_process regulation of excretion;GO:0045121,cellular_component membrane raft;GO:0045159,molecular_function myosin II binding;GO:0045177,cellular_component apical part of cell;GO:0045198,biological_process establishment of epithelial cell apical/basal polarity;GO:0045859,biological_process regulation of protein kinase activity;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050780,molecular_function dopamine receptor binding;GO:0051683,biological_process establishment of Golgi localization;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060088,biological_process auditory receptor cell stereocilium organization;GO:0060158,biological_process phospholipase C-activating dopamine receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070293,biological_process renal absorption;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070851,molecular_function growth factor receptor binding;GO:0071944,cellular_component cell periphery;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0097225,cellular_component sperm midpiece;GO:0097291,biological_process renal phosphate ion absorption;GO:2000146,biological_process negative regulation of cell motility;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	SLC9A3R1, NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; K13365	SLC9A3 regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:11075]
ENSG00000106066	1.78	2.74	1.13	2.99	3.40	2.56	-0.678558966092964	1.84845119116443	0.0105724181608034	0.119088408920193	7:28995230-29195451:-	CPVL	7;GO:0004180,molecular_function carboxypeptidase activity;GO:0004185,molecular_function serine-type carboxypeptidase activity;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome	NA	carboxypeptidase%2C vitellogenic like [Source:HGNC Symbol%3BAcc:HGNC:14399]
ENSG00000108389	11.89	13.11	12.52	11.46	10.94	10.84	0.183196429818461	5.42963095145732	0.0106035651924072	0.119274062510386	17:58489528-58517905:-	MTMR4	21;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0014894,biological_process response to denervation involved in regulation of muscle adaptation;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031901,cellular_component early endosome membrane;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0046872,molecular_function metal ion binding;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	NA	myotubularin related protein 4 [Source:HGNC Symbol%3BAcc:HGNC:7452]
ENSG00000169020	117.03	116.34	115.91	151.55	132.63	128.07	-0.226569268596624	4.72604609528195	0.01060811770011	0.119274062510386	4:672435-674338:-	ATP5I	17;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046034,biological_process ATP metabolic process	ATPeF0E, ATP5I; F-type H+-transporting ATPase subunit e; K02129	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit E [Source:HGNC Symbol%3BAcc:HGNC:846]
ENSG00000115604	2.58	2.69	3.31	4.17	3.14	4.68	-0.469466063683622	2.56519631472405	0.0106700755687266	0.119789816673113	2:102311528-102398775:+	IL18R1	14;GO:0004872,molecular_function receptor activity;GO:0004908,molecular_function interleukin-1 receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030101,biological_process natural killer cell activation;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0035655,biological_process interleukin-18-mediated signaling pathway;GO:0042008,molecular_function interleukin-18 receptor activity;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0045063,biological_process T-helper 1 cell differentiation	IL18R1, IL1RRP, CD218a; interleukin 18 receptor 1; K05173	interleukin 18 receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:5988]
ENSG00000124772	0.42	0.63	0.93	0.82	1.70	1.11	-0.859422107046164	0.906203831250974	0.0106732890711724	0.119789816673113	6:36740774-36840002:-	CPNE5	8;GO:0003674,molecular_function molecular_function;GO:0030154,biological_process cell differentiation;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043204,cellular_component perikaryon;GO:0070062,cellular_component extracellular exosome;GO:1903861,biological_process positive regulation of dendrite extension	NA	copine 5 [Source:HGNC Symbol%3BAcc:HGNC:2318]
ENSG00000123609	55.21	46.80	61.29	68.12	58.47	67.80	-0.235577795090003	5.7876470095006	0.01073385194165	0.120360708357454	2:151270464-151290057:-	NMI	16;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007259,biological_process JAK-STAT cascade;GO:0032480,biological_process negative regulation of type I interferon production;GO:0042802,molecular_function identical protein binding;GO:0045355,biological_process negative regulation of interferon-alpha biosynthetic process;GO:0045358,biological_process negative regulation of interferon-beta biosynthetic process;GO:0045824,biological_process negative regulation of innate immune response;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:1902524,biological_process positive regulation of protein K48-linked ubiquitination;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	N-myc and STAT interactor [Source:HGNC Symbol%3BAcc:HGNC:7854]
ENSG00000160213	614.54	690.88	626.49	559.44	607.35	555.23	0.176887342425809	7.83661800285405	0.0108135574218192	0.121145025520796	21:43772510-43776445:-	CSTB	21;GO:0002020,molecular_function protease binding;GO:0003723,molecular_function RNA binding;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008344,biological_process adult locomotory behavior;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045861,biological_process negative regulation of proteolysis;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	cystatin B [Source:HGNC Symbol%3BAcc:HGNC:2482]
ENSG00000092969	43.73	38.27	40.02	35.40	35.98	37.23	0.18284860918332	5.67743764322881	0.0108600174814412	0.121555813342768	1:218346234-218444619:+	TGFB2	119;GO:0000902,biological_process cell morphogenesis;GO:0001501,biological_process skeletal system development;GO:0001525,biological_process angiogenesis;GO:0001540,molecular_function beta-amyloid binding;GO:0001654,biological_process eye development;GO:0001666,biological_process response to hypoxia;GO:0001822,biological_process kidney development;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001843,biological_process neural tube closure;GO:0001942,biological_process hair follicle development;GO:0002576,biological_process platelet degranulation;GO:0003007,biological_process heart morphogenesis;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003149,biological_process membranous septum morphogenesis;GO:0003179,biological_process heart valve morphogenesis;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003184,biological_process pulmonary valve morphogenesis;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003274,biological_process endocardial cushion fusion;GO:0003289,biological_process atrial septum primum morphogenesis;GO:0003407,biological_process neural retina development;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005102,molecular_function receptor binding;GO:0005114,molecular_function type II transforming growth factor beta receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006468,biological_process protein phosphorylation;GO:0007050,biological_process cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007184,biological_process SMAD protein import into nucleus;GO:0007267,biological_process cell-cell signaling;GO:0007435,biological_process salivary gland morphogenesis;GO:0007507,biological_process heart development;GO:0008083,molecular_function growth factor activity;GO:0008219,biological_process cell death;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008347,biological_process glial cell migration;GO:0008584,biological_process male gonad development;GO:0009611,biological_process response to wounding;GO:0009790,biological_process embryo development;GO:0010002,biological_process cardioblast differentiation;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010693,biological_process negative regulation of alkaline phosphatase activity;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0010936,biological_process negative regulation of macrophage cytokine production;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016049,biological_process cell growth;GO:0016477,biological_process cell migration;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030097,biological_process hemopoiesis;GO:0030199,biological_process collagen fibril organization;GO:0030307,biological_process positive regulation of cell growth;GO:0030308,biological_process negative regulation of cell growth;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030424,cellular_component axon;GO:0030509,biological_process BMP signaling pathway;GO:0030593,biological_process neutrophil chemotaxis;GO:0031012,cellular_component extracellular matrix;GO:0031069,biological_process hair follicle morphogenesis;GO:0031093,cellular_component platelet alpha granule lumen;GO:0032147,biological_process activation of protein kinase activity;GO:0032570,biological_process response to progesterone;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0032909,biological_process regulation of transforming growth factor beta2 production;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0034714,molecular_function type III transforming growth factor beta receptor binding;GO:0035910,biological_process ascending aorta morphogenesis;GO:0042060,biological_process wound healing;GO:0042416,biological_process dopamine biosynthetic process;GO:0042476,biological_process odontogenesis;GO:0042493,biological_process response to drug;GO:0042637,biological_process catagen;GO:0042704,biological_process uterine wall breakdown;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045216,biological_process cell-cell junction organization;GO:0045726,biological_process positive regulation of integrin biosynthetic process;GO:0045778,biological_process positive regulation of ossification;GO:0045787,biological_process positive regulation of cell cycle;GO:0045823,biological_process positive regulation of heart contraction;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046982,molecular_function protein heterodimerization activity;GO:0048103,biological_process somatic stem cell division;GO:0048468,biological_process cell development;GO:0048566,biological_process embryonic digestive tract development;GO:0048666,biological_process neuron development;GO:0048699,biological_process generation of neurons;GO:0048839,biological_process inner ear development;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050714,biological_process positive regulation of protein secretion;GO:0050777,biological_process negative regulation of immune response;GO:0050778,biological_process positive regulation of immune response;GO:0051781,biological_process positive regulation of cell division;GO:0051795,biological_process positive regulation of catagen;GO:0051891,biological_process positive regulation of cardioblast differentiation;GO:0060021,biological_process palate development;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060065,biological_process uterus development;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060395,biological_process SMAD protein signal transduction;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060413,biological_process atrial septum morphogenesis;GO:0061626,biological_process pharyngeal arch artery morphogenesis;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1902256,biological_process regulation of apoptotic process involved in outflow tract morphogenesis;GO:1903701,biological_process substantia propria of cornea development;GO:1904888,biological_process cranial skeletal system development;GO:1905006,biological_process negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:1905007,biological_process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	TGFB2; transforming growth factor beta-2; K13376	transforming growth factor beta 2 [Source:HGNC Symbol%3BAcc:HGNC:11768]
ENSG00000166886	16.64	14.68	15.70	13.88	14.11	12.59	0.230479598255799	4.53371745686152	0.0109231306074262	0.122152090297281	12:57088893-57095476:+	NAB2	16;GO:0001958,biological_process endochondral ossification;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0014037,biological_process Schwann cell differentiation;GO:0016480,biological_process negative regulation of transcription from RNA polymerase III promoter;GO:0042552,biological_process myelination;GO:0042802,molecular_function identical protein binding;GO:0045682,biological_process regulation of epidermis development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:1902949,biological_process positive regulation of tau-protein kinase activity	NA	NGFI-A binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:7627]
ENSG00000126778	6.96	5.03	7.01	8.97	7.47	9.21	-0.405163042212873	2.78092385172339	0.0109743926591059	0.122614883958129	14:60643414-60658259:-	SIX1	76;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001223,molecular_function transcription coactivator binding;GO:0001657,biological_process ureteric bud development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001759,biological_process organ induction;GO:0001822,biological_process kidney development;GO:0003151,biological_process outflow tract morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0007519,biological_process skeletal muscle tissue development;GO:0007605,biological_process sensory perception of sound;GO:0008283,biological_process cell proliferation;GO:0008582,biological_process regulation of synaptic growth at neuromuscular junction;GO:0010468,biological_process regulation of gene expression;GO:0014842,biological_process regulation of skeletal muscle satellite cell proliferation;GO:0021610,biological_process facial nerve morphogenesis;GO:0022008,biological_process neurogenesis;GO:0030855,biological_process epithelial cell differentiation;GO:0030878,biological_process thyroid gland development;GO:0030910,biological_process olfactory placode formation;GO:0032880,biological_process regulation of protein localization;GO:0034504,biological_process protein localization to nucleus;GO:0035909,biological_process aorta morphogenesis;GO:0042472,biological_process inner ear morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043586,biological_process tongue development;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045664,biological_process regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048513,biological_process animal organ development;GO:0048538,biological_process thymus development;GO:0048665,biological_process neuron fate specification;GO:0048699,biological_process generation of neurons;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0048839,biological_process inner ear development;GO:0048856,biological_process anatomical structure development;GO:0050678,biological_process regulation of epithelial cell proliferation;GO:0051451,biological_process myoblast migration;GO:0060037,biological_process pharyngeal system development;GO:0061055,biological_process myotome development;GO:0061197,biological_process fungiform papilla morphogenesis;GO:0061551,biological_process trigeminal ganglion development;GO:0071599,biological_process otic vesicle development;GO:0072001,biological_process renal system development;GO:0072075,biological_process metanephric mesenchyme development;GO:0072095,biological_process regulation of branch elongation involved in ureteric bud branching;GO:0072107,biological_process positive regulation of ureteric bud formation;GO:0072172,biological_process mesonephric tubule formation;GO:0072193,biological_process ureter smooth muscle cell differentiation;GO:0072513,biological_process positive regulation of secondary heart field cardioblast proliferation;GO:0090103,biological_process cochlea morphogenesis;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0090191,biological_process negative regulation of branching involved in ureteric bud morphogenesis;GO:1905243,biological_process cellular response to 3,3',5-triiodo-L-thyronine;GO:2000729,biological_process positive regulation of mesenchymal cell proliferation involved in ureter development;GO:2001014,biological_process regulation of skeletal muscle cell differentiation	SIX1; homeobox protein SIX1; K15614	SIX homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:10887]
ENSG00000177868	45.30	47.30	43.86	56.72	54.01	57.89	-0.298249189916667	3.35629243324465	0.0110533624782515	0.123207962824064	1:42807051-42817252:-	SVBP	5;GO:0005576,cellular_component extracellular region;GO:0009306,biological_process protein secretion;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0045177,cellular_component apical part of cell	NA	small vasohibin binding protein [Source:HGNC Symbol%3BAcc:HGNC:29204]
ENSG00000173212	1.30	0.97	1.15	1.59	2.37	1.81	-0.718780727717959	0.876192203740147	0.0110633260634928	0.123207962824064	1:116111754-116135240:+	MAB21L3	1;GO:0005515,molecular_function protein binding	NA	mab-21 like 3 [Source:HGNC Symbol%3BAcc:HGNC:26787]
ENSG00000145284	9.86	11.82	9.53	11.96	14.10	12.54	-0.304839439761397	3.80426115284047	0.0110690486639103	0.123207962824064	4:82629538-82798857:-	SCD5	15;GO:0004768,molecular_function stearoyl-CoA 9-desaturase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016717,molecular_function oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0046872,molecular_function metal ion binding;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0055114,biological_process oxidation-reduction process;GO:1903966,biological_process monounsaturated fatty acid biosynthetic process	SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]; K00507	stearoyl-CoA desaturase 5 [Source:HGNC Symbol%3BAcc:HGNC:21088]
ENSG00000138750	35.47	32.47	33.98	39.11	37.79	38.34	-0.162652666758917	5.98920917477763	0.0110826736346354	0.123207962824064	4:76114658-76148515:-	NUP54	34;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006605,biological_process protein targeting;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006999,biological_process nuclear pore organization;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0036228,biological_process protein targeting to nuclear inner membrane;GO:0042306,biological_process regulation of protein import into nucleus;GO:0043234,cellular_component protein complex;GO:0043657,cellular_component host cell;GO:0044613,cellular_component nuclear pore central transport channel;GO:0051028,biological_process mRNA transport;GO:0051260,biological_process protein homooligomerization;GO:0051290,biological_process protein heterotetramerization;GO:0051291,biological_process protein heterooligomerization;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070208,biological_process protein heterotrimerization;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP54, NUP57; nuclear pore complex protein Nup54; K14308	nucleoporin 54 [Source:HGNC Symbol%3BAcc:HGNC:17359]
ENSG00000143502	11.06	10.88	10.51	7.85	10.37	8.68	0.282865401351534	4.0482319051436	0.0110844652484619	0.123207962824064	1:223220818-223364202:-	SUSD4	7;GO:0002376,biological_process immune system process;GO:0005576,cellular_component extracellular region;GO:0006958,biological_process complement activation, classical pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030449,biological_process regulation of complement activation;GO:0045087,biological_process innate immune response	NA	sushi domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25470]
ENSG00000080546	4.27	4.85	5.20	3.37	4.41	3.05	0.415521923731081	2.89965660869228	0.0110964284686606	0.123207962824064	6:108986436-109094819:-	SESN1	16;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042149,biological_process cellular response to glucose starvation;GO:0051920,molecular_function peroxiredoxin activity;GO:0055114,biological_process oxidation-reduction process;GO:0061700,cellular_component GATOR2 complex;GO:0070728,molecular_function leucine binding;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0098869,biological_process cellular oxidant detoxification;GO:1901031,biological_process regulation of response to reactive oxygen species;GO:1904262,biological_process negative regulation of TORC1 signaling	SESN1_3; sestrin 1/3; K10141	sestrin 1 [Source:HGNC Symbol%3BAcc:HGNC:21595]
ENSG00000134748	35.77	36.45	36.17	42.96	40.27	40.72	-0.182487018222838	5.18740262788383	0.0110969550017968	0.123207962824064	1:52404563-52420839:+	PRPF38A	10;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0031965,cellular_component nuclear membrane;GO:0071011,cellular_component precatalytic spliceosome	NA	pre-mRNA processing factor 38A [Source:HGNC Symbol%3BAcc:HGNC:25930]
ENSG00000198563	183.89	169.82	180.75	205.57	191.76	203.78	-0.157230958432179	8.1787098020234	0.0111748869670714	0.123962352030614	6:31530218-31542448:-	DDX39B	45;GO:0000166,molecular_function nucleotide binding;GO:0000245,biological_process spliceosomal complex assembly;GO:0000346,cellular_component transcription export complex;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001889,biological_process liver development;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005687,cellular_component U4 snRNP;GO:0005688,cellular_component U6 snRNP;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008186,molecular_function RNA-dependent ATPase activity;GO:0008380,biological_process RNA splicing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017070,molecular_function U6 snRNA binding;GO:0030621,molecular_function U4 snRNA binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0032403,molecular_function protein complex binding;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0042802,molecular_function identical protein binding;GO:0043008,molecular_function ATP-dependent protein binding;GO:0043234,cellular_component protein complex;GO:0045727,biological_process positive regulation of translation;GO:0046784,biological_process viral mRNA export from host cell nucleus;GO:0051028,biological_process mRNA transport;GO:0061051,biological_process positive regulation of cell growth involved in cardiac muscle cell development;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:2000002,biological_process negative regulation of DNA damage checkpoint;GO:2000573,biological_process positive regulation of DNA biosynthetic process	DDX39B, UAP56, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]; K12812	DExD-box helicase 39B [Source:HGNC Symbol%3BAcc:HGNC:13917]
ENSG00000175354	33.39	29.98	31.19	36.38	34.92	36.33	-0.172025740067372	5.69240591138662	0.0112089543233322	0.124229241085288	18:12785477-12929643:-	PTPN2	54;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010888,biological_process negative regulation of lipid storage;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0019905,molecular_function syntaxin binding;GO:0030183,biological_process B cell differentiation;GO:0030217,biological_process T cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0042593,biological_process glucose homeostasis;GO:0045650,biological_process negative regulation of macrophage differentiation;GO:0045722,biological_process positive regulation of gluconeogenesis;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0050922,biological_process negative regulation of chemotaxis;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0060336,biological_process negative regulation of interferon-gamma-mediated signaling pathway;GO:0060339,biological_process negative regulation of type I interferon-mediated signaling pathway;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity;GO:0070104,biological_process negative regulation of interleukin-6-mediated signaling pathway;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0097677,molecular_function STAT family protein binding;GO:1902202,biological_process regulation of hepatocyte growth factor receptor signaling pathway;GO:1902206,biological_process negative regulation of interleukin-2-mediated signaling pathway;GO:1902215,biological_process negative regulation of interleukin-4-mediated signaling pathway;GO:1902227,biological_process negative regulation of macrophage colony-stimulating factor signaling pathway;GO:1902233,biological_process negative regulation of positive thymic T cell selection;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903899,biological_process positive regulation of PERK-mediated unfolded protein response;GO:2000587,biological_process negative regulation of platelet-derived growth factor receptor-beta signaling pathway	NA	protein tyrosine phosphatase%2C non-receptor type 2 [Source:HGNC Symbol%3BAcc:HGNC:9650]
ENSG00000185359	43.43	42.49	45.80	51.82	48.29	48.90	-0.16525198237176	6.83607617941329	0.0112257372070815	0.124251726127197	17:81683325-81703138:+	HGS	36;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006622,biological_process protein targeting to lysosome;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010324,biological_process membrane invagination;GO:0010628,biological_process positive regulation of gene expression;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0019904,molecular_function protein domain specific binding;GO:0031901,cellular_component early endosome membrane;GO:0032585,cellular_component multivesicular body membrane;GO:0033565,cellular_component ESCRT-0 complex;GO:0036258,biological_process multivesicular body assembly;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042176,biological_process regulation of protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043405,biological_process regulation of MAP kinase activity;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046872,molecular_function metal ion binding;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072657,biological_process protein localization to membrane;GO:1903543,biological_process positive regulation of exosomal secretion	HGS, HRS, VPS27; hepatocyte growth factor-regulated tyrosine kinase substrate; K12182	hepatocyte growth factor-regulated tyrosine kinase substrate [Source:HGNC Symbol%3BAcc:HGNC:4897]
ENSG00000135315	5.05	4.70	4.74	4.00	4.21	4.28	0.228180915026359	4.26860433699904	0.0112348423129276	0.124251726127197	6:84124240-84227635:-	CEP162	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005879,cellular_component axonemal microtubule;GO:0030030,biological_process cell projection organization;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 162 [Source:HGNC Symbol%3BAcc:HGNC:21107]
ENSG00000150938	64.78	66.32	63.80	55.57	62.61	56.75	0.167453342979578	7.59368778167215	0.0112492762667765	0.124251726127197	2:36355925-36551135:+	CRIM1	15;GO:0001558,biological_process regulation of cell growth;GO:0004857,molecular_function enzyme inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005010,molecular_function insulin-like growth factor-activated receptor activity;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0007399,biological_process nervous system development;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030165,molecular_function PDZ domain binding;GO:0043086,biological_process negative regulation of catalytic activity;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0070062,cellular_component extracellular exosome	NA	cysteine rich transmembrane BMP regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:2359]
ENSG00000275832	4.15	3.99	4.60	5.17	4.82	5.07	-0.227335611297006	4.40682722877727	0.0112575840712248	0.124251726127197	17:38419279-38512392:+	ARHGAP23	6;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome	NA	Rho GTPase activating protein 23 [Source:HGNC Symbol%3BAcc:HGNC:29293]
ENSG00000136874	18.32	16.49	16.57	20.94	19.18	21.25	-0.241863578885561	4.14961987439679	0.0112626097427633	0.124251726127197	9:99906632-99970341:+	STX17	37;GO:0000149,molecular_function SNARE binding;GO:0000421,cellular_component autophagosome membrane;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006906,biological_process vesicle fusion;GO:0006914,biological_process autophagy;GO:0007030,biological_process Golgi organization;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016240,biological_process autophagosome docking;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030868,cellular_component smooth endoplasmic reticulum membrane;GO:0030897,cellular_component HOPS complex;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0048278,biological_process vesicle docking;GO:0097111,biological_process endoplasmic reticulum-Golgi intermediate compartment organization;GO:0097352,biological_process autophagosome maturation	STX17; syntaxin 17; K08491	syntaxin 17 [Source:HGNC Symbol%3BAcc:HGNC:11432]
ENSG00000145217	4.27	4.17	3.72	3.44	3.35	2.88	0.343473170879865	3.02118312008525	0.0112804253447949	0.124251726127197	4:979072-993440:-	SLC26A1	25;GO:0005254,molecular_function chloride channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0008271,molecular_function secondary active sulfate transmembrane transporter activity;GO:0008272,biological_process sulfate transport;GO:0015106,molecular_function bicarbonate transmembrane transporter activity;GO:0015108,molecular_function chloride transmembrane transporter activity;GO:0015116,molecular_function sulfate transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0019531,molecular_function oxalate transmembrane transporter activity;GO:0019532,biological_process oxalate transport;GO:0042391,biological_process regulation of membrane potential;GO:0050428,biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:1902358,biological_process sulfate transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 26 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10993]
ENSG00000198959	159.52	116.62	165.95	227.70	140.17	216.86	-0.391427046020647	8.46443106001983	0.0112810517477927	0.124251726127197	20:38127386-38166578:-	TGM2	32;GO:0001974,biological_process blood vessel remodeling;GO:0003810,molecular_function protein-glutamine gamma-glutamyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018149,biological_process peptide cross-linking;GO:0018153,biological_process isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine;GO:0019904,molecular_function protein domain specific binding;GO:0031012,cellular_component extracellular matrix;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043277,biological_process apoptotic cell clearance;GO:0045785,biological_process positive regulation of cell adhesion;GO:0046872,molecular_function metal ion binding;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051260,biological_process protein homooligomerization;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0060445,biological_process branching involved in salivary gland morphogenesis;GO:0060662,biological_process salivary gland cavitation;GO:0070062,cellular_component extracellular exosome	TGM2; transglutaminase 2 [EC:2.3.2.13]; K05625	transglutaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:11778]
ENSG00000120756	14.19	14.38	14.28	15.87	17.76	16.10	-0.203380502063503	4.87302464105263	0.0113467085156629	0.124864089366067	3:142596386-142713664:+	PLS1	19;GO:0001951,biological_process intestinal D-glucose absorption;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005884,cellular_component actin filament;GO:0005903,cellular_component brush border;GO:0032432,cellular_component actin filament bundle;GO:0032532,biological_process regulation of microvillus length;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051639,biological_process actin filament network formation;GO:0051764,biological_process actin crosslink formation;GO:0070062,cellular_component extracellular exosome;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:1902896,biological_process terminal web assembly;GO:1990357,cellular_component terminal web	NA	plastin 1 [Source:HGNC Symbol%3BAcc:HGNC:9090]
ENSG00000147144	1.40	1.94	1.56	2.51	2.18	2.12	-0.482173749881586	2.09863111924768	0.0113599899623094	0.124899517628119	X:49053571-49069857:+	CCDC120	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0007275,biological_process multicellular organism development;GO:0030426,cellular_component growth cone;GO:0042995,cellular_component cell projection	NA	coiled-coil domain containing 120 [Source:HGNC Symbol%3BAcc:HGNC:28910]
ENSG00000161896	0.52	0.08	0.84	1.58	0.86	0.80	-1.07904410868461	0.187782097739537	0.0113934437636939	0.125156475609498	6:33721669-33746905:-	IP6K3	22;GO:0000166,molecular_function nucleotide binding;GO:0000827,molecular_function inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828,molecular_function inositol hexakisphosphate kinase activity;GO:0000829,molecular_function inositol heptakisphosphate kinase activity;GO:0000831,molecular_function inositol hexakisphosphate 6-kinase activity;GO:0000832,molecular_function inositol hexakisphosphate 5-kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0008440,molecular_function inositol-1,4,5-trisphosphate 3-kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032958,biological_process inositol phosphate biosynthetic process;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0052723,molecular_function inositol hexakisphosphate 1-kinase activity;GO:0052724,molecular_function inositol hexakisphosphate 3-kinase activity;GO:0052836,molecular_function inositol 5-diphosphate pentakisphosphate 5-kinase activity;GO:0052839,molecular_function inositol diphosphate tetrakisphosphate kinase activity	IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]; K07756	inositol hexakisphosphate kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:17269]
ENSG00000163904	16.76	17.47	16.64	14.09	15.35	15.41	0.190406176166231	5.02639487354527	0.0114092996803849	0.125219838136709	3:185582495-185633551:+	SENP2	27;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0016925,biological_process protein sumoylation;GO:0016926,biological_process protein desumoylation;GO:0016929,molecular_function SUMO-specific protease activity;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031648,biological_process protein destabilization;GO:0031965,cellular_component nuclear membrane;GO:0045444,biological_process fat cell differentiation;GO:0051028,biological_process mRNA transport;GO:0070139,molecular_function SUMO-specific endopeptidase activity	SENP2, AXAM2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]; K03345	SUMO1/sentrin/SMT3 specific peptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:23116]
ENSG00000157881	5.46	6.27	6.07	4.94	5.18	4.80	0.261415081127313	3.87186941170589	0.0114220235991845	0.125248744643708	1:2508532-2526628:-	PANK4	8;GO:0000166,molecular_function nucleotide binding;GO:0004594,molecular_function pantothenate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	coaW; type II pantothenate kinase [EC:2.7.1.33]; K09680	pantothenate kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:19366]
ENSG00000170296	557.69	630.68	650.25	531.65	572.75	527.29	0.183688207831827	7.69156372153245	0.0116752053991444	0.12778297095398	17:7240013-7242770:-	GABARAP	39;GO:0000045,biological_process autophagosome assembly;GO:0000139,cellular_component Golgi membrane;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000421,cellular_component autophagosome membrane;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005776,cellular_component autophagosome;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0005930,cellular_component axoneme;GO:0006605,biological_process protein targeting;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0007268,biological_process chemical synaptic transmission;GO:0008017,molecular_function microtubule binding;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0044297,cellular_component cell body;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048487,molecular_function beta-tubulin binding;GO:0050811,molecular_function GABA receptor binding;GO:0061024,biological_process membrane organization;GO:0097225,cellular_component sperm midpiece;GO:0097352,biological_process autophagosome maturation	NA	GABA type A receptor-associated protein [Source:HGNC Symbol%3BAcc:HGNC:4067]
ENSG00000113761	8.50	9.51	9.74	10.28	11.92	12.66	-0.322236531337695	3.41530989952854	0.0116929781839309	0.12778297095398	5:177022695-177081189:+	ZNF346	13;GO:0002039,molecular_function p53 binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0019899,molecular_function enzyme binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	NA	zinc finger protein 346 [Source:HGNC Symbol%3BAcc:HGNC:16403]
ENSG00000213465	33.27	34.97	31.20	28.62	30.36	23.06	0.288177052892189	4.0690137720628	0.0116932470510852	0.12778297095398	11:65014112-65022184:+	ARL2	31;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0007021,biological_process tubulin complex assembly;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016328,cellular_component lateral plasma membrane;GO:0031113,biological_process regulation of microtubule polymerization;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0034260,biological_process negative regulation of GTPase activity;GO:0050796,biological_process regulation of insulin secretion;GO:0051457,biological_process maintenance of protein location in nucleus;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly	NA	ADP ribosylation factor like GTPase 2 [Source:HGNC Symbol%3BAcc:HGNC:693]
ENSG00000183098	19.42	15.95	17.14	14.65	14.89	15.83	0.228038442032679	4.77498674647941	0.0116943087894725	0.12778297095398	13:93226841-94407401:+	GPC6	18;GO:0001523,biological_process retinoid metabolic process;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0031225,cellular_component anchored component of membrane;GO:0043202,cellular_component lysosomal lumen;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:1904929,molecular_function coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	NA	glypican 6 [Source:HGNC Symbol%3BAcc:HGNC:4454]
ENSG00000172071	8.50	9.83	9.05	7.33	8.49	7.83	0.218741215798861	4.86723716157421	0.011741411820553	0.128184824035642	2:88556740-88627576:-	EIF2AK3	58;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001525,biological_process angiogenesis;GO:0002063,biological_process chondrocyte development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004694,molecular_function eukaryotic translation initiation factor 2alpha kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006983,biological_process ER overload response;GO:0006986,biological_process response to unfolded protein;GO:0007029,biological_process endoplasmic reticulum organization;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010628,biological_process positive regulation of gene expression;GO:0010998,biological_process regulation of translational initiation by eIF2 alpha phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017148,biological_process negative regulation of translation;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019722,biological_process calcium-mediated signaling;GO:0019899,molecular_function enzyme binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030073,biological_process insulin secretion;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030282,biological_process bone mineralization;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031018,biological_process endocrine pancreas development;GO:0031642,biological_process negative regulation of myelination;GO:0032055,biological_process negative regulation of translation in response to stress;GO:0032057,biological_process negative regulation of translational initiation in response to stress;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036492,biological_process eiF2alpha phosphorylation in response to endoplasmic reticulum stress;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0042149,biological_process cellular response to glucose starvation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:0046777,biological_process protein autophosphorylation;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051260,biological_process protein homooligomerization;GO:0051879,molecular_function Hsp90 protein binding;GO:0060734,biological_process regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0070417,biological_process cellular response to cold;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1902235,biological_process regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1990737,biological_process response to manganese-induced endoplasmic reticulum stress	EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]; K08860	eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:3255]
ENSG00000086015	19.26	18.46	19.30	17.95	15.58	17.37	0.176016222138963	6.64428185303785	0.0117685215760787	0.128341943244561	1:45786986-46036124:+	MAST2	23;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007010,biological_process cytoskeleton organization;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019902,molecular_function phosphatase binding;GO:0035556,biological_process intracellular signal transduction;GO:0045075,biological_process regulation of interleukin-12 biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0048515,biological_process spermatid differentiation	NA	microtubule associated serine/threonine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:19035]
ENSG00000244122	0.48	0.99	0.77	0.32	0.32	0.43	1.01118837943986	0.0384773255814709	0.0117764821844481	0.128341943244561	2:233681937-233773299:+	UGT1A7	24;GO:0001972,molecular_function retinoic acid binding;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005080,molecular_function protein kinase C binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007588,biological_process excretion;GO:0008152,biological_process metabolic process;GO:0009804,biological_process coumarin metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0017144,biological_process drug metabolic process;GO:0042573,biological_process retinoic acid metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046982,molecular_function protein heterodimerization activity;GO:0051552,biological_process flavone metabolic process;GO:0052695,biological_process cellular glucuronidation;GO:0052696,biological_process flavonoid glucuronidation;GO:0052697,biological_process xenobiotic glucuronidation	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 1 member A7 [Source:HGNC Symbol%3BAcc:HGNC:12539]
ENSG00000123575	22.57	19.70	19.03	22.90	24.96	24.41	-0.221915316099132	4.70798587084249	0.0118448944449479	0.128974276092227	X:104166619-104195902:+	FAM199X	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 199%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:25195]
ENSG00000110046	7.40	8.06	7.39	6.79	7.14	6.09	0.200158234837347	5.38104988034797	0.0118664752121896	0.129096018237432	11:64894545-64917248:-	ATG2A	13;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0019898,cellular_component extrinsic component of membrane;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044804,biological_process nucleophagy	NA	autophagy related 2A [Source:HGNC Symbol%3BAcc:HGNC:29028]
ENSG00000165304	40.21	40.79	36.14	44.11	45.89	43.19	-0.174677599140682	6.43628738539392	0.011887578727114	0.129212359666958	9:36572861-36677683:+	MELK	30;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030010,biological_process establishment of cell polarity;GO:0030097,biological_process hemopoiesis;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046777,biological_process protein autophosphorylation;GO:0061351,biological_process neural precursor cell proliferation	NA	maternal embryonic leucine zipper kinase [Source:HGNC Symbol%3BAcc:HGNC:16870]
ENSG00000160211	357.58	413.63	385.58	325.75	374.39	314.14	0.201262182919134	9.32933004486127	0.0119379696687936	0.129646559491456	X:154531390-154547572:-	G6PD	40;GO:0004345,molecular_function glucose-6-phosphate dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005536,molecular_function glucose binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0006629,biological_process lipid metabolic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006739,biological_process NADP metabolic process;GO:0006740,biological_process NADPH regeneration;GO:0006749,biological_process glutathione metabolic process;GO:0009051,biological_process pentose-phosphate shunt, oxidative branch;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010041,biological_process response to iron(III) ion;GO:0010734,biological_process negative regulation of protein glutathionylation;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019322,biological_process pentose biosynthetic process;GO:0021762,biological_process substantia nigra development;GO:0030246,molecular_function carbohydrate binding;GO:0032094,biological_process response to food;GO:0034599,biological_process cellular response to oxidative stress;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043249,biological_process erythrocyte maturation;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0045471,biological_process response to ethanol;GO:0046390,biological_process ribose phosphate biosynthetic process;GO:0050661,molecular_function NADP binding;GO:0051156,biological_process glucose 6-phosphate metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0061052,biological_process negative regulation of cell growth involved in cardiac muscle cell development;GO:0070062,cellular_component extracellular exosome;GO:1904879,biological_process positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]; K00036	glucose-6-phosphate dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:4057]
ENSG00000173040	4.11	3.37	4.69	5.27	4.72	5.01	-0.279902467315626	4.20075927432536	0.0119984173373482	0.130189120986454	4:5542771-5709548:-	EVC2	11;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042995,cellular_component cell projection;GO:0060170,cellular_component ciliary membrane;GO:0098797,cellular_component plasma membrane protein complex	NA	EvC ciliary complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:19747]
ENSG00000073331	18.20	17.17	18.75	20.17	20.67	20.23	-0.16008768138084	6.18191576162406	0.0120177707102755	0.130285229542926	4:112285508-112442620:+	ALPK1	7;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	alpha kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:20917]
ENSG00000198931	49.66	56.37	48.47	58.37	60.96	58.31	-0.195059662177089	5.4462165457413	0.0120677686540893	0.130569169455243	16:88809338-88811944:-	APRT	21;GO:0002055,molecular_function adenine binding;GO:0003999,molecular_function adenine phosphoribosyltransferase activity;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006166,biological_process purine ribonucleoside salvage;GO:0006168,biological_process adenine salvage;GO:0007595,biological_process lactation;GO:0007625,biological_process grooming behavior;GO:0009116,biological_process nucleoside metabolic process;GO:0016208,molecular_function AMP binding;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034774,cellular_component secretory granule lumen;GO:0043101,biological_process purine-containing compound salvage;GO:0043312,biological_process neutrophil degranulation;GO:0044209,biological_process AMP salvage;GO:0046083,biological_process adenine metabolic process;GO:0070062,cellular_component extracellular exosome	APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]; K00759	adenine phosphoribosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:626]
ENSG00000072042	46.71	52.99	44.36	42.69	44.36	37.08	0.223324267372486	5.41583843588771	0.0120717799419752	0.130569169455243	14:67676800-67695814:-	RDH11	13;GO:0001523,biological_process retinoid metabolic process;GO:0004745,molecular_function retinol dehydrogenase activity;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0042572,biological_process retinol metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0052650,molecular_function NADP-retinol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process	RDH11; retinol dehydrogenase 11 [EC:1.1.1.300]; K11152	retinol dehydrogenase 11 (all-trans/9-cis/11-cis) [Source:HGNC Symbol%3BAcc:HGNC:17964]
ENSG00000152217	1.16	1.19	1.27	0.96	0.55	1.05	0.510542797373852	2.39821633052015	0.0120848850018601	0.130569169455243	18:44680172-45068510:+	SETBP1	5;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0016604,cellular_component nuclear body	NA	SET binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15573]
ENSG00000101353	5.33	6.04	5.74	5.19	4.72	4.57	0.247174587948445	4.10293740634015	0.0120926520164071	0.130569169455243	20:37101225-37179588:-	MROH8	NA	NA	maestro heat like repeat family member 8 [Source:HGNC Symbol%3BAcc:HGNC:16125]
ENSG00000089723	7.74	8.29	7.33	11.72	8.85	10.30	-0.396481593313518	2.70497422552332	0.0120965556169765	0.130569169455243	14:94026328-94048930:+	OTUB2	14;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019784,molecular_function NEDD8-specific protease activity;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043130,molecular_function ubiquitin binding;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination	NA	OTU deubiquitinase%2C ubiquitin aldehyde binding 2 [Source:HGNC Symbol%3BAcc:HGNC:20351]
ENSG00000197024	5.72	4.47	5.04	3.93	4.17	4.13	0.339791406841978	3.16807625328785	0.0121450639231734	0.130910293664375	7:149126415-149182802:+	ZNF398	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 398 [Source:HGNC Symbol%3BAcc:HGNC:18373]
ENSG00000101624	5.92	5.90	5.14	6.88	7.69	6.39	-0.294907385834204	3.67281687837765	0.0121492514542303	0.130910293664375	18:12661832-12702777:-	CEP76	12;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0043234,cellular_component protein complex;GO:0046599,biological_process regulation of centriole replication;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 76 [Source:HGNC Symbol%3BAcc:HGNC:25727]
ENSG00000143365	1.80	1.70	2.36	3.33	2.47	2.63	-0.501531264481619	2.07077964465736	0.0121612063635713	0.130925459315708	1:151806070-151831872:-	RORC	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006805,biological_process xenobiotic metabolic process;GO:0007275,biological_process multicellular organism development;GO:0007623,biological_process circadian rhythm;GO:0008142,molecular_function oxysterol binding;GO:0008270,molecular_function zinc ion binding;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016604,cellular_component nuclear body;GO:0019218,biological_process regulation of steroid metabolic process;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032922,biological_process circadian regulation of gene expression;GO:0036315,biological_process cellular response to sterol;GO:0042753,biological_process positive regulation of circadian rhythm;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0060612,biological_process adipose tissue development;GO:0060850,biological_process regulation of transcription involved in cell fate commitment;GO:0072539,biological_process T-helper 17 cell differentiation;GO:0098531,molecular_function transcription factor activity, direct ligand regulated sequence-specific DNA binding	NR1F3, RORC; RAR-related orphan receptor gamma; K08534	RAR related orphan receptor C [Source:HGNC Symbol%3BAcc:HGNC:10260]
ENSG00000113240	15.90	15.29	16.05	12.46	15.02	13.20	0.230023732826384	4.514815235188	0.0122374552463408	0.131632176752884	5:178602663-178630615:-	CLK4	15;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0043484,biological_process regulation of RNA splicing;GO:0046777,biological_process protein autophosphorylation	NA	CDC like kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:13659]
ENSG00000137802	3.44	3.24	3.66	3.13	2.86	2.71	0.266958946301359	3.86420735654872	0.0122487566541982	0.131639667834253	15:41774433-41827855:+	MAPKBP1	14;GO:0000922,cellular_component spindle pole;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005682,cellular_component U5 snRNP;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0008380,biological_process RNA splicing;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097431,cellular_component mitotic spindle pole;GO:1900425,biological_process negative regulation of defense response to bacterium;GO:2000483,biological_process negative regulation of interleukin-8 secretion	NA	mitogen-activated protein kinase binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29536]
ENSG00000088756	3.81	3.04	3.01	4.69	3.71	4.38	-0.355841274201654	3.20794648329529	0.0122617338024014	0.131665139869558	18:6729717-6915716:+	ARHGAP28	7;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:1904425,biological_process negative regulation of GTP binding	NA	Rho GTPase activating protein 28 [Source:HGNC Symbol%3BAcc:HGNC:25509]
ENSG00000052795	4.82	4.61	4.71	3.44	3.74	4.54	0.280019483987013	3.97347655120262	0.0122966291975827	0.131925720163867	4:158769137-158908049:+	FNIP2	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0042030,molecular_function ATPase inhibitor activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0051087,molecular_function chaperone binding	NA	folliculin interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:29280]
ENSG00000148120	5.98	5.98	6.01	4.55	5.80	4.50	0.288298950767305	3.90553129408072	0.0123103635700632	0.131959018130565	9:94726700-95087218:+	C9orf3	14;GO:0002003,biological_process angiotensin maturation;GO:0004177,molecular_function aminopeptidase activity;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity	NA	chromosome 9 open reading frame 3 [Source:HGNC Symbol%3BAcc:HGNC:1361]
ENSG00000177189	25.48	24.92	24.99	22.07	22.09	23.69	0.163494937521139	5.75760517189095	0.0123291137551802	0.131962079530208	X:20149910-20267100:-	RPS6KA3	33;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001501,biological_process skeletal system development;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007417,biological_process central nervous system development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030307,biological_process positive regulation of cell growth;GO:0032496,biological_process response to lipopolysaccharide;GO:0035556,biological_process intracellular signal transduction;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043555,biological_process regulation of translation in response to stress;GO:0043620,biological_process regulation of DNA-templated transcription in response to stress;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]; K04373	ribosomal protein S6 kinase A3 [Source:HGNC Symbol%3BAcc:HGNC:10432]
ENSG00000074855	6.58	5.83	6.68	4.88	5.75	5.75	0.236694532277908	4.5873247238419	0.0123319110815308	0.131962079530208	19:17323222-17334829:-	ANO8	11;GO:0005229,molecular_function intracellular calcium activated chloride channel activity;GO:0005622,cellular_component intracellular;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006821,biological_process chloride transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:1902476,biological_process chloride transmembrane transport	NA	anoctamin 8 [Source:HGNC Symbol%3BAcc:HGNC:29329]
ENSG00000232838	27.03	27.53	25.75	33.89	30.90	38.49	-0.356352203495411	2.92926449889319	0.0123606157239194	0.132155316951776	20:18137872-18143169:+	PET117	2;GO:0005739,cellular_component mitochondrion;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	PET117 homolog [Source:HGNC Symbol%3BAcc:HGNC:40045]
ENSG00000153561	17.46	16.78	15.62	19.21	19.46	19.78	-0.217978742343763	4.41750676715554	0.0124299311876433	0.132559455515687	2:86720172-86778041:+	RMND5A	7;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0034657,cellular_component GID complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	NA	required for meiotic nuclear division 5 homolog A [Source:HGNC Symbol%3BAcc:HGNC:25850]
ENSG00000131408	55.07	56.44	54.72	48.56	52.65	48.36	0.16362432146418	6.18545608387324	0.0124313601997068	0.132559455515687	19:50329652-50382982:+	NR1H2	49;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001133,molecular_function RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0010884,biological_process positive regulation of lipid storage;GO:0010887,biological_process negative regulation of cholesterol storage;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032369,biological_process negative regulation of lipid transport;GO:0032376,biological_process positive regulation of cholesterol transport;GO:0034191,molecular_function apolipoprotein A-I receptor binding;GO:0042632,biological_process cholesterol homeostasis;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044255,biological_process cellular lipid metabolic process;GO:0045723,biological_process positive regulation of fatty acid biosynthetic process;GO:0045861,biological_process negative regulation of proteolysis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0048550,biological_process negative regulation of pinocytosis;GO:0051006,biological_process positive regulation of lipoprotein lipase activity;GO:0051117,molecular_function ATPase binding;GO:0055088,biological_process lipid homeostasis;GO:0060336,biological_process negative regulation of interferon-gamma-mediated signaling pathway;GO:0090108,biological_process positive regulation of high-density lipoprotein particle assembly;GO:0090187,biological_process positive regulation of pancreatic juice secretion;GO:0090340,biological_process positive regulation of secretion of lysosomal enzymes;GO:2000188,biological_process regulation of cholesterol homeostasis	NR1H2, LXRB; liver X receptor beta; K08535	nuclear receptor subfamily 1 group H member 2 [Source:HGNC Symbol%3BAcc:HGNC:7965]
ENSG00000167074	11.11	9.83	10.72	9.96	7.88	7.37	0.347193474837362	3.3090882111635	0.0124318706203367	0.132559455515687	22:41367332-41399326:+	TEF	15;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process	NA	TEF%2C PAR bZIP transcription factor [Source:HGNC Symbol%3BAcc:HGNC:11722]
ENSG00000273136	10.98	10.28	10.99	9.71	9.01	10.06	0.177168243512197	5.58371851279039	0.0124411315295074	0.132559455515687	1:120723922-120841481:+	NBPF26	3;GO:0005509,molecular_function calcium ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	NBPF member 26 [Source:HGNC Symbol%3BAcc:HGNC:49571]
ENSG00000104324	29.83	32.40	32.54	36.06	38.78	34.02	-0.189384296459793	5.59194259251063	0.0124668203090522	0.132719245708632	8:96645226-97149654:+	CPQ	18;GO:0004180,molecular_function carboxypeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006508,biological_process proteolysis;GO:0006590,biological_process thyroid hormone generation;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0042246,biological_process tissue regeneration;GO:0042803,molecular_function protein homodimerization activity;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070573,molecular_function metallodipeptidase activity	NA	carboxypeptidase Q [Source:HGNC Symbol%3BAcc:HGNC:16910]
ENSG00000198189	56.19	60.42	54.22	62.48	65.90	65.40	-0.173658007397973	5.77768385036165	0.0124820218484811	0.132767212686543	4:87336609-87391386:-	HSD17B11	12;GO:0004303,molecular_function estradiol 17-beta-dehydrogenase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006703,biological_process estrogen biosynthetic process;GO:0006710,biological_process androgen catabolic process;GO:0016229,molecular_function steroid dehydrogenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol%3BAcc:HGNC:22960]
ENSG00000120805	80.68	94.41	87.65	73.40	83.20	74.05	0.196752799517882	5.76409834682657	0.012609320762013	0.1340064200504	12:101393119-101407820:-	ARL1	22;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0007030,biological_process Golgi organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008047,molecular_function enzyme activator activity;GO:0009404,biological_process toxin metabolic process;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0031584,biological_process activation of phospholipase D activity;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0046872,molecular_function metal ion binding;GO:0048193,biological_process Golgi vesicle transport;GO:0070062,cellular_component extracellular exosome	NA	ADP ribosylation factor like GTPase 1 [Source:HGNC Symbol%3BAcc:HGNC:692]
ENSG00000171163	13.17	15.54	16.16	12.48	13.26	12.54	0.237726701724604	4.58241006238691	0.0126496722717128	0.134320258262422	1:248850005-248859144:-	ZNF692	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 692 [Source:HGNC Symbol%3BAcc:HGNC:26049]
ENSG00000177697	589.48	633.45	591.62	544.23	562.27	540.77	0.15095110883567	8.77597386970996	0.0127007006075098	0.134746834735914	11:832842-839831:+	CD151	14;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005604,cellular_component basement membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0031581,biological_process hemidesmosome assembly;GO:0042098,biological_process T cell proliferation	NA	CD151 molecule (Raph blood group) [Source:HGNC Symbol%3BAcc:HGNC:1630]
ENSG00000115109	7.34	6.79	6.53	8.25	8.65	7.72	-0.237554469249385	4.18056227586862	0.0127135775072476	0.134768264387246	2:120013004-120179119:+	EPB41L5	43;GO:0000904,biological_process cell morphogenesis involved in differentiation;GO:0001701,biological_process in utero embryonic development;GO:0001756,biological_process somitogenesis;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001839,biological_process neural plate morphogenesis;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0003382,biological_process epithelial cell morphogenesis;GO:0003383,biological_process apical constriction;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006931,biological_process substrate-dependent cell migration, cell attachment to substrate;GO:0007398,biological_process ectoderm development;GO:0007492,biological_process endoderm development;GO:0007498,biological_process mesoderm development;GO:0007509,biological_process mesoderm migration involved in gastrulation;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009826,biological_process unidimensional cell growth;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0019904,molecular_function protein domain specific binding;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0031032,biological_process actomyosin structure organization;GO:0031252,cellular_component cell leading edge;GO:0032091,biological_process negative regulation of protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032525,biological_process somite rostral/caudal axis specification;GO:0032587,cellular_component ruffle membrane;GO:0048318,biological_process axial mesoderm development;GO:0048319,biological_process axial mesoderm morphogenesis;GO:0048339,biological_process paraxial mesoderm development;GO:0048617,biological_process embryonic foregut morphogenesis;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0070201,biological_process regulation of establishment of protein localization;GO:0070986,biological_process left/right axis specification;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus	NA	erythrocyte membrane protein band 4.1 like 5 [Source:HGNC Symbol%3BAcc:HGNC:19819]
ENSG00000172878	8.50	9.03	7.91	10.88	9.43	11.68	-0.326307830246021	3.29223625716757	0.0127382456180409	0.13491454168664	2:171999582-172082430:+	METAP1D	9;GO:0004177,molecular_function aminopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0018206,biological_process peptidyl-methionine modification;GO:0031365,biological_process N-terminal protein amino acid modification;GO:0046872,molecular_function metal ion binding	NA	methionyl aminopeptidase type 1D%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:32583]
ENSG00000139289	72.33	61.88	74.95	64.35	48.86	64.12	0.251342929498414	6.28119553890769	0.0127818633487917	0.135111595561461	12:76025446-76033932:-	PHLDA1	9;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045210,biological_process FasL biosynthetic process	NA	pleckstrin homology like domain family A member 1 [Source:HGNC Symbol%3BAcc:HGNC:8933]
ENSG00000158470	74.14	86.21	76.89	87.99	103.66	85.36	-0.213576267160739	6.64270608016221	0.0127864042734196	0.135111595561461	20:49632944-49713878:-	B4GALT5	15;GO:0000139,cellular_component Golgi membrane;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	B4GALT5; beta-1,4-galactosyltransferase 5 [EC:2.4.1.-]; K09905	beta-1%2C4-galactosyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:928]
ENSG00000006118	18.71	20.56	20.44	17.44	18.35	17.69	0.168809991825246	5.87105259649629	0.0127901076979854	0.135111595561461	11:60924462-60937159:+	TMEM132A	12;GO:0000139,cellular_component Golgi membrane;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome	NA	transmembrane protein 132A [Source:HGNC Symbol%3BAcc:HGNC:31092]
ENSG00000132840	1.69	1.58	1.69	0.96	1.04	0.97	0.74801648171672	0.663478874752492	0.0128003896221927	0.135111595561461	5:79069716-79089466:+	BHMT2	15;GO:0000096,biological_process sulfur amino acid metabolic process;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0009086,biological_process methionine biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0033477,biological_process S-methylmethionine metabolic process;GO:0046500,biological_process S-adenosylmethionine metabolic process;GO:0046872,molecular_function metal ion binding;GO:0047150,molecular_function betaine-homocysteine S-methyltransferase activity;GO:0061627,molecular_function S-methylmethionine-homocysteine S-methyltransferase activity;GO:0070062,cellular_component extracellular exosome;GO:0071267,biological_process L-methionine salvage	NA	betaine--homocysteine S-methyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:1048]
ENSG00000142945	45.44	49.69	42.03	49.90	55.33	51.95	-0.186793694715811	6.81076699152466	0.0128296957529353	0.135268199510654	1:44739817-44767767:+	KIF2C	40;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007019,biological_process microtubule depolymerization;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008017,molecular_function microtubule binding;GO:0008283,biological_process cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0019237,molecular_function centromeric DNA binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030951,biological_process establishment or maintenance of microtubule cytoskeleton polarity;GO:0035371,cellular_component microtubule plus-end;GO:0051010,molecular_function microtubule plus-end binding;GO:0051301,biological_process cell division;GO:0051310,biological_process metaphase plate congression;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0051983,biological_process regulation of chromosome segregation	KIF2_24, MCAK; kinesin family member 2/24; K10393	kinesin family member 2C [Source:HGNC Symbol%3BAcc:HGNC:6393]
ENSG00000140105	148.44	98.22	161.97	203.32	139.19	199.25	-0.394710638683366	8.1011295789753	0.0128470009523345	0.135268199510654	14:100333787-100376805:-	WARS	26;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004830,molecular_function tryptophan-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006436,biological_process tryptophanyl-tRNA aminoacylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010835,biological_process regulation of protein ADP-ribosylation;GO:0016874,molecular_function ligase activity;GO:0019210,molecular_function kinase inhibitor activity;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0045765,biological_process regulation of angiogenesis;GO:0070062,cellular_component extracellular exosome	WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]; K01867	tryptophanyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:12729]
ENSG00000142185	0.14	0.08	0.06	0.26	0.15	0.23	-1.11457327114821	-0.194982870529022	0.0128479180877355	0.135268199510654	21:44350162-44443081:+	TRPM2	59;GO:0001659,biological_process temperature homeostasis;GO:0002407,biological_process dendritic cell chemotaxis;GO:0005216,molecular_function ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005384,molecular_function manganese ion transmembrane transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0006816,biological_process calcium ion transport;GO:0006828,biological_process manganese ion transport;GO:0006979,biological_process response to oxidative stress;GO:0009408,biological_process response to heat;GO:0014074,biological_process response to purine-containing compound;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032024,biological_process positive regulation of insulin secretion;GO:0033194,biological_process response to hydroperoxide;GO:0034220,biological_process ion transmembrane transport;GO:0035579,cellular_component specific granule membrane;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043204,cellular_component perikaryon;GO:0043312,biological_process neutrophil degranulation;GO:0044849,biological_process estrous cycle;GO:0047631,molecular_function ADP-ribose diphosphatase activity;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051489,biological_process regulation of filopodium assembly;GO:0055085,biological_process transmembrane transport;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070588,biological_process calcium ion transmembrane transport;GO:0070821,cellular_component tertiary granule membrane;GO:0071277,biological_process cellular response to calcium ion;GO:0071415,biological_process cellular response to purine-containing compound;GO:0071421,biological_process manganese ion transmembrane transport;GO:0071502,biological_process cellular response to temperature stimulus;GO:0071577,biological_process zinc II ion transmembrane transport;GO:0097028,biological_process dendritic cell differentiation;GO:0097553,biological_process calcium ion transmembrane import into cytosol;GO:0098655,biological_process cation transmembrane transport;GO:0098703,biological_process calcium ion import across plasma membrane;GO:0099604,molecular_function ligand-gated calcium channel activity;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1903223,biological_process positive regulation of oxidative stress-induced neuron death;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]; K04977	transient receptor potential cation channel subfamily M member 2 [Source:HGNC Symbol%3BAcc:HGNC:12339]
ENSG00000058085	17.56	12.83	16.86	20.39	16.27	21.27	-0.27902972354701	5.98240119455284	0.0128723897666654	0.135410995062388	1:183186237-183244900:+	LAMC2	18;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005607,cellular_component laminin-2 complex;GO:0005615,cellular_component extracellular space;GO:0005938,cellular_component cell cortex;GO:0007155,biological_process cell adhesion;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0031581,biological_process hemidesmosome assembly;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048731,biological_process system development;GO:0070831,biological_process basement membrane assembly	LAMC2; laminin, gamma 2; K06246	laminin subunit gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:6493]
ENSG00000123454	1.72	1.70	1.79	1.01	1.47	1.10	0.552593133181888	1.5119160591176	0.0129089494197501	0.135578158753014	9:133636359-133659344:+	DBH	44;GO:0001816,biological_process cytokine production;GO:0001974,biological_process blood vessel remodeling;GO:0001975,biological_process response to amphetamine;GO:0002443,biological_process leukocyte mediated immunity;GO:0003824,molecular_function catalytic activity;GO:0004497,molecular_function monooxygenase activity;GO:0004500,molecular_function dopamine beta-monooxygenase activity;GO:0005507,molecular_function copper ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006589,biological_process octopamine biosynthetic process;GO:0007268,biological_process chemical synaptic transmission;GO:0007613,biological_process memory;GO:0007626,biological_process locomotory behavior;GO:0008306,biological_process associative learning;GO:0008542,biological_process visual learning;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016715,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen;GO:0030658,cellular_component transport vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031418,molecular_function L-ascorbic acid binding;GO:0034466,cellular_component chromaffin granule lumen;GO:0034774,cellular_component secretory granule lumen;GO:0042127,biological_process regulation of cell proliferation;GO:0042309,biological_process homoiothermy;GO:0042420,biological_process dopamine catabolic process;GO:0042421,biological_process norepinephrine biosynthetic process;GO:0042423,biological_process catecholamine biosynthetic process;GO:0042584,cellular_component chromaffin granule membrane;GO:0042593,biological_process glucose homeostasis;GO:0042596,biological_process fear response;GO:0042711,biological_process maternal behavior;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0046872,molecular_function metal ion binding;GO:0048149,biological_process behavioral response to ethanol;GO:0048265,biological_process response to pain;GO:0050900,biological_process leukocyte migration;GO:0055114,biological_process oxidation-reduction process;GO:2001236,biological_process regulation of extrinsic apoptotic signaling pathway	DBH; dopamine beta-monooxygenase [EC:1.14.17.1]; K00503	dopamine beta-hydroxylase [Source:HGNC Symbol%3BAcc:HGNC:2689]
ENSG00000108639	40.32	43.42	44.52	37.87	39.32	36.80	0.180869888728618	5.38237603283958	0.0129101251628183	0.135578158753014	17:78168557-78173527:+	SYNGR2	8;GO:0005515,molecular_function protein binding;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031594,cellular_component neuromuscular junction;GO:0070062,cellular_component extracellular exosome	NA	synaptogyrin 2 [Source:HGNC Symbol%3BAcc:HGNC:11499]
ENSG00000145494	81.60	84.84	80.85	94.53	97.32	88.90	-0.172558541002055	5.67633473278069	0.0129235790087756	0.135604722092926	5:1801399-1816605:+	NDUFS6	18;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006631,biological_process fatty acid metabolic process;GO:0006936,biological_process muscle contraction;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0010259,biological_process multicellular organism aging;GO:0016020,cellular_component membrane;GO:0022904,biological_process respiratory electron transport chain;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035264,biological_process multicellular organism growth;GO:0055114,biological_process oxidation-reduction process;GO:0061458,biological_process reproductive system development;GO:0070469,cellular_component respiratory chain;GO:0070584,biological_process mitochondrion morphogenesis;GO:0072358,biological_process cardiovascular system development	NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6; K03939	NADH:ubiquinone oxidoreductase subunit S6 [Source:HGNC Symbol%3BAcc:HGNC:7713]
ENSG00000163541	62.14	71.52	61.97	53.48	61.78	56.68	0.194801909475303	6.01837499923637	0.0129370700411974	0.135631630423465	2:84423522-84460045:-	SUCLG1	15;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004775,molecular_function succinate-CoA ligase (ADP-forming) activity;GO:0004776,molecular_function succinate-CoA ligase (GDP-forming) activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006099,biological_process tricarboxylic acid cycle;GO:0008152,biological_process metabolic process;GO:0016874,molecular_function ligase activity;GO:0048037,molecular_function cofactor binding;GO:0070062,cellular_component extracellular exosome	LSC1; succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5]; K01899	succinate-CoA ligase alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:11449]
ENSG00000100997	61.84	66.15	60.66	56.53	59.22	52.47	0.175938093243008	6.56704757382171	0.0129747946279515	0.13581976376065	20:25294742-25390983:-	ABHD12	13;GO:0004622,molecular_function lysophospholipase activity;GO:0005886,cellular_component plasma membrane;GO:0006660,biological_process phosphatidylserine catabolic process;GO:0007628,biological_process adult walking behavior;GO:0010996,biological_process response to auditory stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0046464,biological_process acylglycerol catabolic process;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0047372,molecular_function acylglycerol lipase activity;GO:0052651,biological_process monoacylglycerol catabolic process	NA	abhydrolase domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:15868]
ENSG00000104643	1.87	1.79	2.13	2.35	2.56	3.39	-0.504915999300427	2.03052911541776	0.0129816419320286	0.13581976376065	8:11284415-11328146:+	MTMR9	9;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0016311,biological_process dephosphorylation;GO:0030234,molecular_function enzyme regulator activity;GO:0050790,biological_process regulation of catalytic activity;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	NA	myotubularin related protein 9 [Source:HGNC Symbol%3BAcc:HGNC:14596]
ENSG00000184860	0.40	0.46	0.71	1.09	0.98	1.02	-0.942294954551019	0.17238716692631	0.0129878401340442	0.13581976376065	16:81988854-82011488:-	SDR42E1	7;GO:0003854,molecular_function 3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0006694,biological_process steroid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0055114,biological_process oxidation-reduction process	NA	short chain dehydrogenase/reductase family 42E%2C member 1 [Source:HGNC Symbol%3BAcc:HGNC:29834]
ENSG00000173926	10.41	8.82	7.45	12.48	10.60	11.63	-0.364486751338574	3.03069624179553	0.0130344040657056	0.136120186686887	5:126867713-127030808:-	MARCH3	12;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0006897,biological_process endocytosis;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0046872,molecular_function metal ion binding	NA	membrane associated ring-CH-type finger 3 [Source:HGNC Symbol%3BAcc:HGNC:28728]
ENSG00000167972	3.66	3.28	3.82	2.95	3.02	3.22	0.24537825708582	4.10692338176709	0.0130385001184813	0.136120186686887	16:2275880-2340746:-	ABCA3	20;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005319,molecular_function lipid transporter activity;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044267,biological_process cellular protein metabolic process;GO:0051384,biological_process response to glucocorticoid;GO:0055085,biological_process transmembrane transport;GO:0097208,cellular_component alveolar lamellar body;GO:0097232,cellular_component lamellar body membrane;GO:0097233,cellular_component alveolar lamellar body membrane	ABCA3; ATP-binding cassette, subfamily A (ABC1), member 3; K05643	ATP binding cassette subfamily A member 3 [Source:HGNC Symbol%3BAcc:HGNC:33]
ENSG00000180370	41.35	43.26	43.28	46.46	48.46	48.82	-0.157802661233778	6.1582429672671	0.0130977948533297	0.136580512516781	3:196739856-196832647:+	PAK2	52;GO:0000166,molecular_function nucleotide binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003824,molecular_function catalytic activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030036,biological_process actin cytoskeleton organization;GO:0030296,molecular_function protein tyrosine kinase activator activity;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031267,molecular_function small GTPase binding;GO:0031295,biological_process T cell costimulation;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0040008,biological_process regulation of growth;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0045296,molecular_function cadherin binding;GO:0046777,biological_process protein autophosphorylation;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0060996,biological_process dendritic spine development;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0071407,biological_process cellular response to organic cyclic compound;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001271,biological_process negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	PAK2; p21-activated kinase 2 [EC:2.7.11.1]; K04410	p21 (RAC1) activated kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:8591]
ENSG00000142655	20.52	21.73	22.04	26.36	24.84	23.65	-0.208321605634369	4.73291544028431	0.0131045992433325	0.136580512516781	1:10472287-10630758:+	PEX14	30;GO:0001650,cellular_component fibrillar center;GO:0003714,molecular_function transcription corepressor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0007031,biological_process peroxisome organization;GO:0008017,molecular_function microtubule binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016558,biological_process protein import into peroxisome matrix;GO:0016560,biological_process protein import into peroxisome matrix, docking;GO:0016561,biological_process protein import into peroxisome matrix, translocation;GO:0032091,biological_process negative regulation of protein binding;GO:0034453,biological_process microtubule anchoring;GO:0036250,biological_process peroxisome transport along microtubule;GO:0043234,cellular_component protein complex;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0044721,biological_process protein import into peroxisome matrix, substrate release;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0048487,molecular_function beta-tubulin binding;GO:0051260,biological_process protein homooligomerization;GO:1901094,biological_process negative regulation of protein homotetramerization;GO:1990429,cellular_component peroxisomal importomer complex	PEX14; peroxin-14; K13343	peroxisomal biogenesis factor 14 [Source:HGNC Symbol%3BAcc:HGNC:8856]
ENSG00000180879	176.77	167.38	168.05	151.19	152.42	159.33	0.158252445144245	6.40178111046896	0.0131315840079922	0.136746939841617	X:153793515-153798505:+	SSR4	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005784,cellular_component Sec61 translocon complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	SSR4; translocon-associated protein subunit delta; K04571	signal sequence receptor subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:11326]
ENSG00000087494	5.25	4.50	5.70	3.18	3.45	4.05	0.549499877132771	1.59793614753466	0.0131716613190706	0.137001591121866	12:27958083-27972705:-	PTHLH	22;GO:0001501,biological_process skeletal system development;GO:0002076,biological_process osteoblast development;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007565,biological_process female pregnancy;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008544,biological_process epidermis development;GO:0010468,biological_process regulation of gene expression;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0046058,biological_process cAMP metabolic process;GO:0051428,molecular_function peptide hormone receptor binding	NA	parathyroid hormone like hormone [Source:HGNC Symbol%3BAcc:HGNC:9607]
ENSG00000075826	14.28	12.58	15.55	17.20	14.95	17.48	-0.211225000392368	5.77129548973618	0.0131781116409819	0.137001591121866	10:100486641-100519864:-	SEC31B	10;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030120,cellular_component vesicle coat;GO:0031410,cellular_component cytoplasmic vesicle	SEC31; protein transport protein SEC31; K14005	SEC31 homolog B%2C COPII coat complex component [Source:HGNC Symbol%3BAcc:HGNC:23197]
ENSG00000125648	39.47	46.43	43.56	36.51	41.47	35.63	0.198474173544141	6.44539510543772	0.0132215660915461	0.137338326271432	19:6436078-6465203:-	SLC25A23	22;GO:0002082,biological_process regulation of oxidative phosphorylation;GO:0005347,molecular_function ATP transmembrane transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0015217,molecular_function ADP transmembrane transporter activity;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0043457,biological_process regulation of cellular respiration;GO:0046872,molecular_function metal ion binding;GO:0051282,biological_process regulation of sequestering of calcium ion;GO:0051503,biological_process adenine nucleotide transport;GO:0055085,biological_process transmembrane transport;GO:0071277,biological_process cellular response to calcium ion;GO:0097274,biological_process urea homeostasis	NA	solute carrier family 25 member 23 [Source:HGNC Symbol%3BAcc:HGNC:19375]
ENSG00000183087	33.99	29.65	29.67	27.31	29.20	26.17	0.188955913064279	5.90346591844513	0.0132604779179497	0.137627351501263	13:113820548-113864067:-	GAS6	95;GO:0001764,biological_process neuron migration;GO:0001786,molecular_function phosphatidylserine binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001961,biological_process positive regulation of cytokine-mediated signaling pathway;GO:0002576,biological_process platelet degranulation;GO:0003104,biological_process positive regulation of glomerular filtration;GO:0005102,molecular_function receptor binding;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0006465,biological_process signal peptide processing;GO:0006468,biological_process protein phosphorylation;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006909,biological_process phagocytosis;GO:0006915,biological_process apoptotic process;GO:0007050,biological_process cell cycle arrest;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007167,biological_process enzyme linked receptor protein signaling pathway;GO:0007596,biological_process blood coagulation;GO:0008283,biological_process cell proliferation;GO:0009267,biological_process cellular response to starvation;GO:0010628,biological_process positive regulation of gene expression;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010934,biological_process macrophage cytokine production;GO:0016032,biological_process viral process;GO:0016477,biological_process cell migration;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019064,biological_process fusion of virus membrane with host plasma membrane;GO:0019079,biological_process viral genome replication;GO:0030168,biological_process platelet activation;GO:0030296,molecular_function protein tyrosine kinase activator activity;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031100,biological_process organ regeneration;GO:0031589,biological_process cell-substrate adhesion;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032148,biological_process activation of protein kinase B activity;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032825,biological_process positive regulation of natural killer cell differentiation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033159,biological_process negative regulation of protein import into nucleus, translocation;GO:0035457,biological_process cellular response to interferon-alpha;GO:0035690,biological_process cellular response to drug;GO:0035754,biological_process B cell chemotaxis;GO:0040008,biological_process regulation of growth;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043277,biological_process apoptotic cell clearance;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043491,biological_process protein kinase B signaling;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046718,biological_process viral entry into host cell;GO:0046813,biological_process receptor-mediated virion attachment to host cell;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0048018,molecular_function receptor agonist activity;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0050711,biological_process negative regulation of interleukin-1 secretion;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050900,biological_process leukocyte migration;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060090,molecular_function binding, bridging;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070168,biological_process negative regulation of biomineral tissue development;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070527,biological_process platelet aggregation;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071307,biological_process cellular response to vitamin K;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0072661,biological_process protein targeting to plasma membrane;GO:0085029,biological_process extracellular matrix assembly;GO:0097028,biological_process dendritic cell differentiation;GO:0097241,biological_process hematopoietic stem cell migration to bone marrow;GO:1900142,biological_process negative regulation of oligodendrocyte apoptotic process;GO:1900165,biological_process negative regulation of interleukin-6 secretion;GO:2000270,biological_process negative regulation of fibroblast apoptotic process;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2000510,biological_process positive regulation of dendritic cell chemotaxis;GO:2000533,biological_process negative regulation of renal albumin absorption;GO:2000669,biological_process negative regulation of dendritic cell apoptotic process	GAS6; growth arrest-specific 6; K05464	growth arrest specific 6 [Source:HGNC Symbol%3BAcc:HGNC:4168]
ENSG00000144677	23.29	27.36	26.23	21.62	23.61	21.31	0.215843184205823	4.84388937131389	0.0134318488433795	0.139253744298064	3:37861959-37984469:+	CTDSPL	12;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003674,molecular_function molecular_function;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005634,cellular_component nucleus;GO:0006470,biological_process protein dephosphorylation;GO:0008150,biological_process biological_process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	CTD small phosphatase like [Source:HGNC Symbol%3BAcc:HGNC:16890]
ENSG00000166123	55.91	45.26	50.71	58.46	60.42	56.16	-0.189577255937639	6.42306181735229	0.0134396185989753	0.139253744298064	16:46884377-46931297:+	GPT2	12;GO:0003824,molecular_function catalytic activity;GO:0004021,molecular_function L-alanine:2-oxoglutarate aminotransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042851,biological_process L-alanine metabolic process;GO:0042853,biological_process L-alanine catabolic process	GPT, ALT; alanine transaminase [EC:2.6.1.2]; K00814	glutamic--pyruvic transaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:18062]
ENSG00000128335	128.30	99.68	127.15	149.24	123.31	151.65	-0.243346088361861	7.4544916528921	0.0134818030913453	0.139474199318799	22:36226202-36239954:-	APOL2	16;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006953,biological_process acute-phase response;GO:0007275,biological_process multicellular organism development;GO:0008035,molecular_function high-density lipoprotein particle binding;GO:0008203,biological_process cholesterol metabolic process;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042157,biological_process lipoprotein metabolic process;GO:0060135,biological_process maternal process involved in female pregnancy	NA	apolipoprotein L2 [Source:HGNC Symbol%3BAcc:HGNC:619]
ENSG00000101266	119.00	99.74	113.26	131.35	121.62	126.43	-0.179050332390803	7.30110351807144	0.0134878502877961	0.139474199318799	20:473590-543821:-	CSNK2A1	48;GO:0000166,molecular_function nucleotide binding;GO:0000785,cellular_component chromatin;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005956,cellular_component protein kinase CK2 complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006457,biological_process protein folding;GO:0006468,biological_process protein phosphorylation;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0008013,molecular_function beta-catenin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016055,biological_process Wnt signaling pathway;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016580,cellular_component Sin3 complex;GO:0016581,cellular_component NuRD complex;GO:0016740,molecular_function transferase activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0021987,biological_process cerebral cortex development;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030307,biological_process positive regulation of cell growth;GO:0031519,cellular_component PcG protein complex;GO:0033574,biological_process response to testosterone;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046777,biological_process protein autophosphorylation;GO:0047485,molecular_function protein N-terminus binding;GO:0048511,biological_process rhythmic process;GO:0051879,molecular_function Hsp90 protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0071174,biological_process mitotic spindle checkpoint;GO:0097421,biological_process liver regeneration;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1903076,biological_process regulation of protein localization to plasma membrane	CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]; K03097	casein kinase 2 alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:2457]
ENSG00000154639	31.83	31.94	28.82	26.01	29.49	25.11	0.210570723148915	5.03756070774922	0.0135125263810217	0.139474199318799	21:17512381-17593579:+	CXADR	48;GO:0001618,molecular_function virus receptor activity;GO:0001669,cellular_component acrosomal vesicle;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005923,cellular_component bicellular tight junction;GO:0007005,biological_process mitochondrion organization;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007507,biological_process heart development;GO:0008013,molecular_function beta-catenin binding;GO:0008354,biological_process germ cell migration;GO:0010669,biological_process epithelial structure maintenance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0016327,cellular_component apicolateral plasma membrane;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030175,cellular_component filopodium;GO:0030426,cellular_component growth cone;GO:0030593,biological_process neutrophil chemotaxis;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0043005,cellular_component neuron projection;GO:0043234,cellular_component protein complex;GO:0044297,cellular_component cell body;GO:0045121,cellular_component membrane raft;GO:0045216,biological_process cell-cell junction organization;GO:0046629,biological_process gamma-delta T cell activation;GO:0046718,biological_process viral entry into host cell;GO:0048739,biological_process cardiac muscle fiber development;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0070633,biological_process transepithelial transport;GO:0071253,molecular_function connexin binding;GO:0086067,biological_process AV node cell to bundle of His cell communication;GO:0086072,biological_process AV node cell-bundle of His cell adhesion involved in cell communication;GO:0086082,molecular_function cell adhesive protein binding involved in AV node cell-bundle of His cell communication;GO:0098904,biological_process regulation of AV node cell action potential	CXADR, CAR; coxsackievirus and adenovirus receptor; K06788	CXADR%2C Ig-like cell adhesion molecule [Source:HGNC Symbol%3BAcc:HGNC:2559]
ENSG00000134758	26.23	26.39	29.04	31.68	29.92	34.92	-0.229091933825282	4.46241259338587	0.0135156116565626	0.139474199318799	18:32091854-32131561:+	RNF138	20;GO:0000209,biological_process protein polyubiquitination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010792,biological_process DNA double-strand break processing involved in repair via single-strand annealing;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035861,cellular_component site of double-strand break;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	ring finger protein 138 [Source:HGNC Symbol%3BAcc:HGNC:17765]
ENSG00000176454	24.04	24.26	24.25	23.58	19.06	20.67	0.208031952028837	5.15906215082316	0.0135240672274856	0.139474199318799	15:34358617-34367278:-	LPCAT4	21;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047166,molecular_function 1-alkenylglycerophosphoethanolamine O-acyltransferase activity;GO:0047184,molecular_function 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192,molecular_function 1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0071617,molecular_function lysophospholipid acyltransferase activity	LPCAT4, AGPAT7; lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]; K13512	lysophosphatidylcholine acyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:30059]
ENSG00000159082	2.40	2.52	2.42	2.11	2.06	1.91	0.280965895492191	3.45775039872634	0.0135283119294155	0.139474199318799	21:32628758-32728048:-	SYNJ1	50;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006836,biological_process neurotransmitter transport;GO:0006897,biological_process endocytosis;GO:0007420,biological_process brain development;GO:0007612,biological_process learning;GO:0008022,molecular_function protein C-terminus binding;GO:0012506,cellular_component vesicle membrane;GO:0014015,biological_process positive regulation of gliogenesis;GO:0016082,biological_process synaptic vesicle priming;GO:0016191,biological_process synaptic vesicle uncoating;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030117,cellular_component membrane coat;GO:0030132,cellular_component clathrin coat of coated pit;GO:0032403,molecular_function protein complex binding;GO:0032526,biological_process response to retinoic acid;GO:0034097,biological_process response to cytokine;GO:0034595,molecular_function phosphatidylinositol phosphate 5-phosphatase activity;GO:0034596,molecular_function phosphatidylinositol phosphate 4-phosphatase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0042578,molecular_function phosphoric ester hydrolase activity;GO:0043005,cellular_component neuron projection;GO:0043195,cellular_component terminal bouton;GO:0043234,cellular_component protein complex;GO:0043647,biological_process inositol phosphate metabolic process;GO:0043812,molecular_function phosphatidylinositol-4-phosphate phosphatase activity;GO:0043813,molecular_function phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0045202,cellular_component synapse;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0048489,biological_process synaptic vesicle transport;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0052658,molecular_function inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0061024,biological_process membrane organization;GO:0097060,cellular_component synaptic membrane;GO:0098793,cellular_component presynapse;GO:1904980,biological_process positive regulation of endosome organization	INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]; K01099	synaptojanin 1 [Source:HGNC Symbol%3BAcc:HGNC:11503]
ENSG00000101493	5.99	5.78	5.86	6.72	6.91	6.85	-0.202390948710874	4.48320635459346	0.0135492804813253	0.139487284661455	18:76358189-76495190:-	ZNF516	18;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0009409,biological_process response to cold;GO:0033613,molecular_function activating transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0050873,biological_process brown fat cell differentiation;GO:0060612,biological_process adipose tissue development	NA	zinc finger protein 516 [Source:HGNC Symbol%3BAcc:HGNC:28990]
ENSG00000196220	0.86	0.74	0.76	1.58	0.97	1.02	-0.574546974086676	1.80989480395859	0.0135569503458282	0.139487284661455	3:8980590-9363053:-	SRGAP3	9;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0030336,biological_process negative regulation of cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048365,molecular_function Rac GTPase binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	SRGAP; SLIT-ROBO Rho GTPase activating protein; K07526	SLIT-ROBO Rho GTPase activating protein 3 [Source:HGNC Symbol%3BAcc:HGNC:19744]
ENSG00000064787	1.16	1.81	1.21	0.54	0.89	1.12	0.691041571703748	1.1992406896479	0.0135666103210957	0.139487284661455	20:53936776-54070594:-	BCAS1	2;GO:0005737,cellular_component cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	breast carcinoma amplified sequence 1 [Source:HGNC Symbol%3BAcc:HGNC:974]
ENSG00000129235	133.21	116.03	111.50	139.80	136.06	139.11	-0.187927805951942	5.5835519091274	0.0135745299179117	0.139487284661455	17:6640757-6644541:+	TXNDC17	9;GO:0004601,molecular_function peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0047134,molecular_function protein-disulfide reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	NA	thioredoxin domain containing 17 [Source:HGNC Symbol%3BAcc:HGNC:28218]
ENSG00000164896	48.97	45.08	44.69	41.32	43.52	39.62	0.170119599445354	6.17867815458729	0.0136129731243843	0.139746268199635	7:151076592-151080866:-	FASTK	16;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0033867,molecular_function Fas-activated serine/threonine kinase activity;GO:0043484,biological_process regulation of RNA splicing;GO:0097190,biological_process apoptotic signaling pathway	NA	Fas activated serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:24676]
ENSG00000081923	8.20	7.77	7.06	7.30	6.33	6.15	0.232258930998118	4.74961695237192	0.0136222496190734	0.139746268199635	18:57646425-57803101:-	ATP8B1	33;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005319,molecular_function lipid transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0006869,biological_process lipid transport;GO:0007030,biological_process Golgi organization;GO:0007605,biological_process sensory perception of sound;GO:0008206,biological_process bile acid metabolic process;GO:0015721,biological_process bile acid and bile salt transport;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0021650,biological_process vestibulocochlear nerve formation;GO:0031526,cellular_component brush border membrane;GO:0032420,cellular_component stereocilium;GO:0032534,biological_process regulation of microvillus assembly;GO:0034220,biological_process ion transmembrane transport;GO:0042995,cellular_component cell projection;GO:0045332,biological_process phospholipid translocation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0060119,biological_process inner ear receptor cell development;GO:1901612,molecular_function cardiolipin binding	NA	ATPase phospholipid transporting 8B1 [Source:HGNC Symbol%3BAcc:HGNC:3706]
ENSG00000197448	133.54	136.03	128.06	116.69	125.81	115.69	0.161907121072105	6.80774935514975	0.0136799518346925	0.140222330407959	7:143244092-143270854:+	GSTK1	18;GO:0004364,molecular_function glutathione transferase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005777,cellular_component peroxisome;GO:0006749,biological_process glutathione metabolic process;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0030855,biological_process epithelial cell differentiation;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GSTK1; glutathione S-transferase kappa 1 [EC:2.5.1.18]; K13299	glutathione S-transferase kappa 1 [Source:HGNC Symbol%3BAcc:HGNC:16906]
ENSG00000158286	9.73	9.70	12.31	8.74	7.50	9.72	0.303031228725614	4.20657861665942	0.0137031106752137	0.140343822451673	1:6205474-6221299:+	RNF207	16;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0010628,biological_process positive regulation of gene expression;GO:0030544,molecular_function Hsp70 protein binding;GO:0044325,molecular_function ion channel binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051087,molecular_function chaperone binding;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0086019,biological_process cell-cell signaling involved in cardiac conduction;GO:1901207,biological_process regulation of heart looping;GO:1902261,biological_process positive regulation of delayed rectifier potassium channel activity;GO:1903762,biological_process positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:1903954,biological_process positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	NA	ring finger protein 207 [Source:HGNC Symbol%3BAcc:HGNC:32947]
ENSG00000198780	0.11	0.24	0.40	0.63	0.53	0.42	-1.05968139964977	-0.0935148459233386	0.0137267977605695	0.140387536334826	5:74777573-74866951:-	FAM169A	4;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0016020,cellular_component membrane	NA	family with sequence similarity 169 member A [Source:HGNC Symbol%3BAcc:HGNC:29138]
ENSG00000112414	13.41	12.76	13.23	13.75	16.53	15.02	-0.187699432333432	5.77016354763007	0.0137362557791583	0.140387536334826	6:142301853-142446266:+	ADGRG6	20;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005518,molecular_function collagen binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007005,biological_process mitochondrion organization;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0010579,biological_process positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway;GO:0014037,biological_process Schwann cell differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019933,biological_process cAMP-mediated signaling;GO:0022011,biological_process myelination in peripheral nervous system;GO:0042552,biological_process myelination;GO:0043236,molecular_function laminin binding;GO:0050840,molecular_function extracellular matrix binding;GO:0060347,biological_process heart trabecula formation	NA	adhesion G protein-coupled receptor G6 [Source:HGNC Symbol%3BAcc:HGNC:13841]
ENSG00000164342	6.51	5.07	6.81	7.65	7.35	7.36	-0.25793285512403	4.22429202883937	0.0137413080356734	0.140387536334826	4:186069151-186088069:+	TLR3	77;GO:0000139,cellular_component Golgi membrane;GO:0001774,biological_process microglial cell activation;GO:0001819,biological_process positive regulation of cytokine production;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002282,biological_process microglial cell activation involved in immune response;GO:0002376,biological_process immune system process;GO:0002730,biological_process regulation of dendritic cell cytokine production;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006972,biological_process hyperosmotic response;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0007252,biological_process I-kappaB phosphorylation;GO:0008584,biological_process male gonad development;GO:0009597,biological_process detection of virus;GO:0009615,biological_process response to virus;GO:0010008,cellular_component endosome membrane;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032722,biological_process positive regulation of chemokine production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0034123,biological_process positive regulation of toll-like receptor signaling pathway;GO:0034128,biological_process negative regulation of MyD88-independent toll-like receptor signaling pathway;GO:0034138,biological_process toll-like receptor 3 signaling pathway;GO:0034346,biological_process positive regulation of type III interferon production;GO:0035458,biological_process cellular response to interferon-beta;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0035690,biological_process cellular response to drug;GO:0036020,cellular_component endolysosome membrane;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0042742,biological_process defense response to bacterium;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043330,biological_process response to exogenous dsRNA;GO:0043331,biological_process response to dsRNA;GO:0045078,biological_process positive regulation of interferon-gamma biosynthetic process;GO:0045080,biological_process positive regulation of chemokine biosynthetic process;GO:0045087,biological_process innate immune response;GO:0045356,biological_process positive regulation of interferon-alpha biosynthetic process;GO:0045359,biological_process positive regulation of interferon-beta biosynthetic process;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0070266,biological_process necroptotic process;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071359,biological_process cellular response to dsRNA;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097527,biological_process necroptotic signaling pathway	TLR3, CD283; toll-like receptor 3; K05401	toll like receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:11849]
ENSG00000185009	27.65	29.87	27.88	25.61	26.25	23.27	0.194274980810299	5.07252339221424	0.0137764385981571	0.140630700920168	10:74120254-74151063:-	AP3M1	17;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006622,biological_process protein targeting to lysosome;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008089,biological_process anterograde axonal transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017137,molecular_function Rab GTPase binding;GO:0030131,cellular_component clathrin adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:1904115,cellular_component axon cytoplasm	NA	adaptor related protein complex 3 mu 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:569]
ENSG00000132970	2.66	2.63	3.30	4.16	3.35	3.99	-0.40533020475415	2.53459952276328	0.0138454177309968	0.141218710184768	13:26557702-26688948:+	WASF3	13;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006461,biological_process protein complex assembly;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0014003,biological_process oligodendrocyte development;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030041,biological_process actin filament polymerization;GO:0031643,biological_process positive regulation of myelination;GO:0070062,cellular_component extracellular exosome	WASF3; WAS protein family, member 3; K06083	WAS protein family member 3 [Source:HGNC Symbol%3BAcc:HGNC:12734]
ENSG00000203797	1.08	0.86	0.73	1.62	1.51	1.52	-0.771788302793451	0.60339625394025	0.0138861105339499	0.141517479522102	6:110391770-110415562:-	DDO	17;GO:0003884,molecular_function D-amino-acid oxidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006531,biological_process aspartate metabolic process;GO:0007320,biological_process insemination;GO:0007625,biological_process grooming behavior;GO:0008445,molecular_function D-aspartate oxidase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019478,biological_process D-amino acid catabolic process;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0042445,biological_process hormone metabolic process;GO:0046416,biological_process D-amino acid metabolic process;GO:0048037,molecular_function cofactor binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	DDO; D-aspartate oxidase [EC:1.4.3.1]; K00272	D-aspartate oxidase [Source:HGNC Symbol%3BAcc:HGNC:2727]
ENSG00000143751	13.99	13.56	14.03	16.82	15.98	15.85	-0.212221846634205	4.36080874045078	0.0139129865035057	0.141573681467586	1:225982701-225999331:-	SDE2	1;GO:0005634,cellular_component nucleus	NA	SDE2 telomere maintenance homolog [Source:HGNC Symbol%3BAcc:HGNC:26643]
ENSG00000134058	18.47	16.46	16.33	20.48	19.07	21.04	-0.226395513750902	4.35494913792342	0.0139144357842951	0.141573681467586	5:69234794-69277430:+	CDK7	47;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005675,cellular_component holo TFIIH complex;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008022,molecular_function protein C-terminus binding;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008283,biological_process cell proliferation;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019907,cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050681,molecular_function androgen receptor binding;GO:0050821,biological_process protein stabilization;GO:0051301,biological_process cell division;GO:0070985,cellular_component TFIIK complex	CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]; K02202	cyclin dependent kinase 7 [Source:HGNC Symbol%3BAcc:HGNC:1778]
ENSG00000163956	125.50	126.22	121.32	109.23	117.86	110.48	0.155679928615715	7.11165852452731	0.0139348606364329	0.141665376805931	4:3506375-3532559:-	LRPAP1	31;GO:0001540,molecular_function beta-amyloid binding;GO:0002091,biological_process negative regulation of receptor internalization;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0005801,cellular_component cis-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0008201,molecular_function heparin binding;GO:0009986,cellular_component cell surface;GO:0010916,biological_process negative regulation of very-low-density lipoprotein particle clearance;GO:0031904,cellular_component endosome lumen;GO:0031982,cellular_component vesicle;GO:0032091,biological_process negative regulation of protein binding;GO:0035473,molecular_function lipase binding;GO:0045056,biological_process transcytosis;GO:0048019,molecular_function receptor antagonist activity;GO:0048237,cellular_component rough endoplasmic reticulum lumen;GO:0048259,biological_process regulation of receptor-mediated endocytosis;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0060548,biological_process negative regulation of cell death;GO:0070326,molecular_function very-low-density lipoprotein particle receptor binding;GO:1900116,biological_process extracellular negative regulation of signal transduction;GO:1900222,biological_process negative regulation of beta-amyloid clearance;GO:1900223,biological_process positive regulation of beta-amyloid clearance	NA	LDL receptor related protein associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6701]
ENSG00000112624	7.27	7.82	7.19	8.60	8.41	8.71	-0.20121017977276	4.70401520522644	0.0139644078767458	0.14180858290637	6:42746957-42868560:+	BICRAL	NA	NA	BRD4 interacting chromatin remodeling complex associated protein like [Source:HGNC Symbol%3BAcc:HGNC:21111]
ENSG00000197780	59.23	55.49	53.82	62.39	71.36	64.65	-0.221390652827002	4.52035781169152	0.0139787889817898	0.14180858290637	1:109062485-109076002:-	TAF13	19;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008022,molecular_function protein C-terminus binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	TATA-box binding protein associated factor 13 [Source:HGNC Symbol%3BAcc:HGNC:11546]
ENSG00000198642	27.36	28.96	27.71	24.96	26.06	24.39	0.166285261662108	5.62375843160552	0.0139832196469345	0.14180858290637	9:21329670-21335380:-	KLHL9	9;GO:0000910,biological_process cytokinesis;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0030496,cellular_component midbody;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification;GO:0051301,biological_process cell division	KLHL9_13; kelch-like protein 9/13; K10447	kelch like family member 9 [Source:HGNC Symbol%3BAcc:HGNC:18732]
ENSG00000179918	38.52	40.03	45.18	49.02	45.48	47.14	-0.182552939249698	5.89919866449275	0.0140045382911749	0.141887446938077	16:30443630-30446181:-	SEPHS2	11;GO:0000166,molecular_function nucleotide binding;GO:0001887,biological_process selenium compound metabolic process;GO:0004756,molecular_function selenide, water dikinase activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0016259,biological_process selenocysteine metabolic process;GO:0016260,biological_process selenocysteine biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]; K01008	selenophosphate synthetase 2 [Source:HGNC Symbol%3BAcc:HGNC:19686]
ENSG00000134569	2.40	2.78	2.70	3.13	3.12	3.10	-0.241641738849354	4.05046792213916	0.0140138572420916	0.141887446938077	11:46856867-46918642:-	LRP4	53;GO:0001822,biological_process kidney development;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001942,biological_process hair follicle development;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0007275,biological_process multicellular organism development;GO:0008104,biological_process protein localization;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009954,biological_process proximal/distal pattern formation;GO:0009986,cellular_component cell surface;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016600,cellular_component flotillin complex;GO:0017147,molecular_function Wnt-protein binding;GO:0030154,biological_process cell differentiation;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030279,biological_process negative regulation of ossification;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030425,cellular_component dendrite;GO:0030509,biological_process BMP signaling pathway;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031594,cellular_component neuromuscular junction;GO:0034185,molecular_function apolipoprotein binding;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043025,cellular_component neuronal cell body;GO:0043113,biological_process receptor clustering;GO:0043235,cellular_component receptor complex;GO:0044332,biological_process Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0048513,biological_process animal organ development;GO:0048813,biological_process dendrite morphogenesis;GO:0048856,biological_process anatomical structure development;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050808,biological_process synapse organization;GO:0051124,biological_process synaptic growth at neuromuscular junction;GO:0051290,biological_process protein heterotetramerization;GO:0060173,biological_process limb development;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0071340,biological_process skeletal muscle acetylcholine-gated channel clustering;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097060,cellular_component synaptic membrane;GO:0097104,biological_process postsynaptic membrane assembly;GO:0097105,biological_process presynaptic membrane assembly;GO:0097110,molecular_function scaffold protein binding;GO:1901631,biological_process positive regulation of presynaptic membrane organization;GO:1904395,biological_process positive regulation of skeletal muscle acetylcholine-gated channel clustering	NA	LDL receptor related protein 4 [Source:HGNC Symbol%3BAcc:HGNC:6696]
ENSG00000160284	2.98	2.25	1.73	1.10	1.64	1.59	0.699640324832953	1.04617474505841	0.0140437683127012	0.142024420912844	21:46161147-46184476:-	SPATC1L	5;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005813,cellular_component centrosome;GO:0008150,biological_process biological_process	NA	spermatogenesis and centriole associated 1 like [Source:HGNC Symbol%3BAcc:HGNC:1298]
ENSG00000037757	14.70	14.14	15.75	11.27	13.32	13.23	0.252570139463156	4.05186357868915	0.0140502689825966	0.142024420912844	19:13764531-13774282:+	MRI1	14;GO:0001650,cellular_component fibrillar center;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009086,biological_process methionine biosynthetic process;GO:0016853,molecular_function isomerase activity;GO:0019509,biological_process L-methionine biosynthetic process from methylthioadenosine;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0044237,biological_process cellular metabolic process;GO:0044249,biological_process cellular biosynthetic process;GO:0046523,molecular_function S-methyl-5-thioribose-1-phosphate isomerase activity	mtnA; methylthioribose-1-phosphate isomerase [EC:5.3.1.23]; K08963	methylthioribose-1-phosphate isomerase 1 [Source:HGNC Symbol%3BAcc:HGNC:28469]
ENSG00000163558	17.06	17.80	15.31	20.52	18.49	19.19	-0.206355872020554	5.02079990269518	0.0140641273663361	0.142048830755354	3:170222364-170305981:+	PRKCI	57;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0006468,biological_process protein phosphorylation;GO:0006612,biological_process protein targeting to membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007015,biological_process actin filament organization;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019904,molecular_function protein domain specific binding;GO:0031252,cellular_component cell leading edge;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034351,biological_process negative regulation of glial cell apoptotic process;GO:0034613,biological_process cellular protein localization;GO:0035089,biological_process establishment of apical/basal cell polarity;GO:0035556,biological_process intracellular signal transduction;GO:0042462,biological_process eye photoreceptor cell development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043220,cellular_component Schmidt-Lanterman incisure;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045171,cellular_component intercellular bridge;GO:0045177,cellular_component apical part of cell;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045216,biological_process cell-cell junction organization;GO:0046326,biological_process positive regulation of glucose import;GO:0046872,molecular_function metal ion binding;GO:0046903,biological_process secretion;GO:0048194,biological_process Golgi vesicle budding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070555,biological_process response to interleukin-1;GO:0070830,biological_process bicellular tight junction assembly;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process	PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]; K06069	protein kinase C iota [Source:HGNC Symbol%3BAcc:HGNC:9404]
ENSG00000147234	0.42	0.53	0.28	0.58	0.74	0.54	-0.609586412289456	1.55581279351452	0.0140803659078803	0.142097221150015	X:107522449-107605251:+	FRMPD3	5;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0070821,cellular_component tertiary granule membrane	NA	FERM and PDZ domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:29382]
ENSG00000176890	168.25	193.68	160.21	197.90	213.39	190.51	-0.194551412479681	7.4600256871526	0.0141337911361761	0.142520511269987	18:657603-673578:+	TYMS	52;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003729,molecular_function mRNA binding;GO:0004799,molecular_function thymidylate synthase activity;GO:0005542,molecular_function folic acid binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006206,biological_process pyrimidine nucleobase metabolic process;GO:0006231,biological_process dTMP biosynthetic process;GO:0006235,biological_process dTTP biosynthetic process;GO:0006417,biological_process regulation of translation;GO:0007568,biological_process aging;GO:0007623,biological_process circadian rhythm;GO:0008144,molecular_function drug binding;GO:0008168,molecular_function methyltransferase activity;GO:0008283,biological_process cell proliferation;GO:0009165,biological_process nucleotide biosynthetic process;GO:0009636,biological_process response to toxic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016740,molecular_function transferase activity;GO:0017148,biological_process negative regulation of translation;GO:0019088,biological_process immortalization of host cell by virus;GO:0019860,biological_process uracil metabolic process;GO:0032259,biological_process methylation;GO:0032570,biological_process response to progesterone;GO:0033189,biological_process response to vitamin A;GO:0034097,biological_process response to cytokine;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0045471,biological_process response to ethanol;GO:0046078,biological_process dUMP metabolic process;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046683,biological_process response to organophosphorus;GO:0048037,molecular_function cofactor binding;GO:0048589,biological_process developmental growth;GO:0051216,biological_process cartilage development;GO:0051384,biological_process response to glucocorticoid;GO:0051593,biological_process response to folic acid;GO:0060574,biological_process intestinal epithelial cell maturation;GO:0071897,biological_process DNA biosynthetic process;GO:0097421,biological_process liver regeneration;GO:1990825,molecular_function sequence-specific mRNA binding	thyA, TYMS; thymidylate synthase [EC:2.1.1.45]; K00560	thymidylate synthetase [Source:HGNC Symbol%3BAcc:HGNC:12441]
ENSG00000115350	18.11	19.06	20.34	15.57	14.69	14.82	0.361830113275487	2.61732924765091	0.0141905521607921	0.142976724003175	2:74958491-74970128:+	POLE4	15;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006270,biological_process DNA replication initiation;GO:0008622,cellular_component epsilon DNA polymerase complex;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0043966,biological_process histone H3 acetylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0071897,biological_process DNA biosynthetic process	POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]; K03506	DNA polymerase epsilon 4%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:18755]
ENSG00000198198	6.23	7.13	6.71	6.21	6.01	5.63	0.178618402122933	6.03466035784303	0.01422281037807	0.143185519240051	1:43389881-43454247:+	SZT2	19;GO:0003674,molecular_function molecular_function;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005777,cellular_component peroxisome;GO:0007417,biological_process central nervous system development;GO:0009791,biological_process post-embryonic development;GO:0016020,cellular_component membrane;GO:0021540,biological_process corpus callosum morphogenesis;GO:0031667,biological_process response to nutrient levels;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042149,biological_process cellular response to glucose starvation;GO:0043473,biological_process pigmentation;GO:0061462,biological_process protein localization to lysosome;GO:0061700,cellular_component GATOR2 complex;GO:0070062,cellular_component extracellular exosome;GO:0140007,cellular_component KICSTOR complex;GO:1901668,biological_process regulation of superoxide dismutase activity;GO:1904262,biological_process negative regulation of TORC1 signaling;GO:1990130,cellular_component Iml1 complex	NA	SZT2%2C KICSTOR complex subunit [Source:HGNC Symbol%3BAcc:HGNC:29040]
ENSG00000123737	33.22	33.65	30.43	36.63	37.16	36.48	-0.170660666791467	5.58888569050726	0.0142998371813811	0.143844310318058	4:121801316-121817021:+	EXOSC9	32;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000228,cellular_component nuclear chromosome;GO:0000467,biological_process exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0006955,biological_process immune response;GO:0017091,molecular_function AU-rich element binding;GO:0030307,biological_process positive regulation of cell growth;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034473,biological_process U1 snRNA 3'-end processing;GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0034476,biological_process U5 snRNA 3'-end processing;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070062,cellular_component extracellular exosome;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071035,biological_process nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038,biological_process nuclear polyadenylation-dependent tRNA catabolic process;GO:0071042,biological_process nuclear polyadenylation-dependent mRNA catabolic process	RRP45, EXOSC9; exosome complex component RRP45; K03678	exosome component 9 [Source:HGNC Symbol%3BAcc:HGNC:9137]
ENSG00000058804	9.81	11.15	9.97	12.11	13.35	11.23	-0.23885765317057	4.51954405498281	0.0143120107330832	0.143850193708309	1:53765459-53838860:-	NDC1	29;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007129,biological_process synapsis;GO:0007283,biological_process spermatogenesis;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031081,biological_process nuclear pore distribution;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0051292,biological_process nuclear pore complex assembly;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070762,cellular_component nuclear pore transmembrane ring;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NDC1, TMEM48; nucleoporin NDC1; K14315	NDC1 transmembrane nucleoporin [Source:HGNC Symbol%3BAcc:HGNC:25525]
ENSG00000164066	3.86	3.34	4.12	4.44	4.87	4.56	-0.272169574975645	3.68142199308493	0.0143983285871634	0.144600689929175	4:127623270-127726737:+	INTU	24;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0009986,cellular_component cell surface;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0021513,biological_process spinal cord dorsal/ventral patterning;GO:0021915,biological_process neural tube development;GO:0030030,biological_process cell projection organization;GO:0030216,biological_process keratinocyte differentiation;GO:0030278,biological_process regulation of ossification;GO:0031069,biological_process hair follicle morphogenesis;GO:0031514,cellular_component motile cilium;GO:0036064,cellular_component ciliary basal body;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0051782,biological_process negative regulation of cell division;GO:0060173,biological_process limb development;GO:0060271,biological_process cilium morphogenesis;GO:1905515,biological_process non-motile cilium assembly	NA	inturned planar cell polarity protein [Source:HGNC Symbol%3BAcc:HGNC:29239]
ENSG00000100600	308.34	296.69	306.23	260.31	295.97	265.36	0.161248263916277	8.82550314799906	0.0144573641019453	0.145076200968025	14:92703806-92748702:-	LGMN	22;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0003014,biological_process renal system process;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005764,cellular_component lysosome;GO:0005770,cellular_component late endosome;GO:0006508,biological_process proteolysis;GO:0006624,biological_process vacuolar protein processing;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010447,biological_process response to acidic pH;GO:0016787,molecular_function hydrolase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032801,biological_process receptor catabolic process;GO:0036021,cellular_component endolysosome lumen;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0042359,biological_process vitamin D metabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045177,cellular_component apical part of cell;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:1901185,biological_process negative regulation of ERBB signaling pathway	LGMN; legumain [EC:3.4.22.34]; K01369	legumain [Source:HGNC Symbol%3BAcc:HGNC:9472]
ENSG00000184887	24.32	21.74	23.12	21.36	19.34	20.35	0.196219681091583	4.98922857328502	0.0145215004668955	0.145597474400189	14:105248489-105251093:+	BTBD6	10;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0022008,biological_process neurogenesis;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	BTB domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:19897]
ENSG00000134874	16.20	16.00	17.23	14.83	15.16	14.23	0.174509770140803	5.42753041191746	0.0145327697399367	0.145597474400189	13:95578201-95644703:-	DZIP1	23;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007281,biological_process germ cell development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0045184,biological_process establishment of protein localization;GO:0046872,molecular_function metal ion binding;GO:0051220,biological_process cytoplasmic sequestering of protein;GO:0060271,biological_process cilium morphogenesis;GO:0097539,cellular_component ciliary transition fiber	NA	DAZ interacting zinc finger protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20908]
ENSG00000128294	37.43	31.29	41.07	30.44	31.00	33.57	0.224893156692852	5.53743388992948	0.014560783365317	0.145622339750501	22:26521982-26596717:-	TPST2	10;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006478,biological_process peptidyl-tyrosine sulfation;GO:0008476,molecular_function protein-tyrosine sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0070062,cellular_component extracellular exosome	NA	tyrosylprotein sulfotransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:12021]
ENSG00000112977	112.03	116.28	110.23	129.28	131.31	120.99	-0.161858613447201	6.30030246242538	0.0145676570477791	0.145622339750501	5:10679229-10761272:-	DAP	9;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010507,biological_process negative regulation of autophagy;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0034198,biological_process cellular response to amino acid starvation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070513,molecular_function death domain binding;GO:0097190,biological_process apoptotic signaling pathway	NA	death associated protein [Source:HGNC Symbol%3BAcc:HGNC:2672]
ENSG00000033170	42.34	48.99	43.39	40.32	42.09	36.43	0.190394981879791	6.26647117032945	0.0145820042873473	0.145622339750501	14:65410591-65744121:+	FUT8	29;GO:0000139,cellular_component Golgi membrane;GO:0001701,biological_process in utero embryonic development;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006491,biological_process N-glycan processing;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007585,biological_process respiratory gaseous exchange;GO:0008424,molecular_function glycoprotein 6-alpha-L-fucosyltransferase activity;GO:0009312,biological_process oligosaccharide biosynthetic process;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0017124,molecular_function SH3 domain binding;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033578,biological_process protein glycosylation in Golgi;GO:0036071,biological_process N-glycan fucosylation;GO:0042355,biological_process L-fucose catabolic process;GO:0043112,biological_process receptor metabolic process;GO:0046368,biological_process GDP-L-fucose metabolic process;GO:0046921,molecular_function alpha-(1->6)-fucosyltransferase activity;GO:0070062,cellular_component extracellular exosome;GO:1900407,biological_process regulation of cellular response to oxidative stress	FUT8; glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]; K00717	fucosyltransferase 8 [Source:HGNC Symbol%3BAcc:HGNC:4019]
ENSG00000131788	24.43	26.11	24.23	22.96	22.63	21.05	0.175482368322464	5.49870666448634	0.0145821774196304	0.145622339750501	1:145848521-145859836:-	PIAS3	24;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008022,molecular_function protein C-terminus binding;GO:0008270,molecular_function zinc ion binding;GO:0009725,biological_process response to hormone;GO:0010628,biological_process positive regulation of gene expression;GO:0015459,molecular_function potassium channel regulator activity;GO:0016607,cellular_component nuclear speck;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0019899,molecular_function enzyme binding;GO:0030425,cellular_component dendrite;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0045202,cellular_component synapse;GO:0045838,biological_process positive regulation of membrane potential;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0065009,biological_process regulation of molecular function	PIAS3; E3 SUMO-protein ligase PIAS3 [EC:2.3.2.-]; K16064	protein inhibitor of activated STAT 3 [Source:HGNC Symbol%3BAcc:HGNC:16861]
ENSG00000196678	9.63	9.74	9.50	11.30	12.00	10.40	-0.211617532339724	4.61042562379307	0.0146303085998731	0.145985547146483	16:20780192-20900349:-	ERI2	8;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0006259,biological_process DNA metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	ERI1 exoribonuclease family member 2 [Source:HGNC Symbol%3BAcc:HGNC:30541]
ENSG00000116761	58.48	50.26	54.88	62.92	58.61	65.11	-0.175174425895647	6.15438013698124	0.0147243838398064	0.146766652339595	1:70411217-70439851:+	CTH	33;GO:0000098,biological_process sulfur amino acid catabolic process;GO:0003824,molecular_function catalytic activity;GO:0003962,molecular_function cystathionine gamma-synthase activity;GO:0004123,molecular_function cystathionine gamma-lyase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006534,biological_process cysteine metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0016846,molecular_function carbon-sulfur lyase activity;GO:0018272,biological_process protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine;GO:0019343,biological_process cysteine biosynthetic process via cystathionine;GO:0019344,biological_process cysteine biosynthetic process;GO:0019346,biological_process transsulfuration;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044524,biological_process protein sulfhydration;GO:0044540,molecular_function L-cystine L-cysteine-lyase (deaminating);GO:0047982,molecular_function homocysteine desulfhydrase activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051289,biological_process protein homotetramerization;GO:0070062,cellular_component extracellular exosome;GO:0070814,biological_process hydrogen sulfide biosynthetic process;GO:0071266,biological_process 'de novo' L-methionine biosynthetic process;GO:0080146,molecular_function L-cysteine desulfhydrase activity;GO:1904831,biological_process positive regulation of aortic smooth muscle cell differentiation;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	CTH; cystathionine gamma-lyase [EC:4.4.1.1]; K01758	cystathionine gamma-lyase [Source:HGNC Symbol%3BAcc:HGNC:2501]
ENSG00000124688	27.18	26.57	30.85	32.93	31.00	34.72	-0.207502280419997	4.89133932722729	0.0147322362696476	0.146766652339595	6:43629539-43640952:+	MAD2L1BP	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007096,biological_process regulation of exit from mitosis;GO:0031965,cellular_component nuclear membrane	NA	MAD2L1 binding protein [Source:HGNC Symbol%3BAcc:HGNC:21059]
ENSG00000173085	19.29	21.38	21.75	23.92	24.70	23.49	-0.198696101112299	4.86950646831481	0.0147860719335382	0.147184852374507	4:83261535-83284914:-	COQ2	13;GO:0002083,molecular_function 4-hydroxybenzoate decaprenyltransferase activity;GO:0004659,molecular_function prenyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006071,biological_process glycerol metabolic process;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016765,molecular_function transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0047293,molecular_function 4-hydroxybenzoate nonaprenyltransferase activity	COQ2; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39]; K06125	coenzyme Q2%2C polyprenyltransferase [Source:HGNC Symbol%3BAcc:HGNC:25223]
ENSG00000008130	21.56	20.30	19.68	17.07	17.72	19.66	0.188206411522535	5.2660717369084	0.0148619512071856	0.147615001544163	1:1751231-1780457:-	NADK	13;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006741,biological_process NADP biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019674,biological_process NAD metabolic process;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding	ppnK, NADK; NAD+ kinase [EC:2.7.1.23]; K00858	NAD kinase [Source:HGNC Symbol%3BAcc:HGNC:29831]
ENSG00000116017	2.88	1.90	2.07	1.44	1.67	1.71	0.531502017062106	1.88626719438965	0.0148682966795736	0.147615001544163	19:925780-975934:+	ARID3A	18;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045121,cellular_component membrane raft;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	AT-rich interaction domain 3A [Source:HGNC Symbol%3BAcc:HGNC:3031]
ENSG00000007392	24.99	25.25	24.93	23.32	21.80	21.39	0.188035742087675	4.88881738449324	0.0148690958250877	0.147615001544163	16:188968-229463:-	LUC7L	9;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005685,cellular_component U1 snRNP;GO:0006376,biological_process mRNA splice site selection;GO:0042802,molecular_function identical protein binding;GO:0045843,biological_process negative regulation of striated muscle tissue development;GO:0050733,molecular_function RS domain binding;GO:0071004,cellular_component U2-type prespliceosome	NA	LUC7 like [Source:HGNC Symbol%3BAcc:HGNC:6723]
ENSG00000158716	23.38	20.39	21.10	25.29	27.13	27.19	-0.277391829278439	3.46462371001256	0.0148768522461732	0.147615001544163	1:159780931-159782543:+	DUSP23	15;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0070062,cellular_component extracellular exosome	NA	dual specificity phosphatase 23 [Source:HGNC Symbol%3BAcc:HGNC:21480]
ENSG00000164929	2.39	1.27	2.17	0.77	1.12	1.35	0.881955483350984	0.251186848024734	0.0148979031687499	0.147705808333621	8:103140709-103230305:+	BAALC	11;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0043005,cellular_component neuron projection;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	BAALC%2C MAP3K1 and KLF4 binding [Source:HGNC Symbol%3BAcc:HGNC:14333]
ENSG00000113615	12.06	14.91	11.74	9.90	12.39	10.34	0.253670428642416	5.32572325129563	0.0149697965816681	0.148204377291247	5:134648788-134727823:+	SEC24A	25;GO:0000139,cellular_component Golgi membrane;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008270,molecular_function zinc ion binding;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030127,cellular_component COPII vesicle coat;GO:0045714,biological_process regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050714,biological_process positive regulation of protein secretion;GO:0090110,biological_process cargo loading into COPII-coated vesicle;GO:2000189,biological_process positive regulation of cholesterol homeostasis	SEC24; protein transport protein SEC24; K14007	SEC24 homolog A%2C COPII coat complex component [Source:HGNC Symbol%3BAcc:HGNC:10703]
ENSG00000197415	8.66	9.32	8.16	6.85	8.43	6.83	0.249968791542662	4.44501691684101	0.0149720687282062	0.148204377291247	3:157259741-157533619:-	VEPH1	2;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	ventricular zone expressed PH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25735]
ENSG00000253598	0.32	0.51	0.45	0.97	0.92	0.64	-0.981634334974431	-0.0173384158550458	0.0150218719433903	0.148402100149332	8:81693606-81696174:-	SLC10A5	9;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0008508,molecular_function bile acid:sodium symporter activity;GO:0015293,molecular_function symporter activity;GO:0015721,biological_process bile acid and bile salt transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 10 member 5 [Source:HGNC Symbol%3BAcc:HGNC:22981]
ENSG00000166965	10.33	10.25	9.66	11.22	12.04	13.65	-0.278718812868987	3.67965338846513	0.0150315590370496	0.148402100149332	15:90954869-90963125:+	RCCD1	2;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane	NA	RCC1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30457]
ENSG00000110719	23.61	22.76	22.72	20.47	20.83	21.27	0.155259849076179	5.81010471836395	0.0150398799121614	0.148402100149332	11:68039015-68050895:+	TCIRG1	33;GO:0000220,cellular_component vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005215,molecular_function transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006968,biological_process cellular defense response;GO:0007035,biological_process vacuolar acidification;GO:0007039,biological_process protein catabolic process in the vacuole;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0016324,cellular_component apical plasma membrane;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0043312,biological_process neutrophil degranulation;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0051117,molecular_function ATPase binding;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly;GO:0090383,biological_process phagosome acidification;GO:0101003,cellular_component ficolin-1-rich granule membrane	ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a; K02154	T-cell immune regulator 1%2C ATPase H+ transporting V0 subunit a3 [Source:HGNC Symbol%3BAcc:HGNC:11647]
ENSG00000204923	2.89	2.06	2.69	4.35	3.75	4.54	-0.691100290529322	0.804524073059222	0.0150560195101245	0.148402100149332	2:68459418-68467258:-	FBXO48	NA	NA	F-box protein 48 [Source:HGNC Symbol%3BAcc:HGNC:33857]
ENSG00000127419	5.87	6.19	6.49	4.37	5.58	5.00	0.322071441502995	3.15827575482189	0.0150683437064018	0.148402100149332	4:932386-958656:+	TMEM175	14;GO:0005267,molecular_function potassium channel activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022841,molecular_function potassium ion leak channel activity;GO:0035751,biological_process regulation of lysosomal lumen pH;GO:0071805,biological_process potassium ion transmembrane transport;GO:0090385,biological_process phagosome-lysosome fusion	NA	transmembrane protein 175 [Source:HGNC Symbol%3BAcc:HGNC:28709]
ENSG00000167711	13.62	13.60	14.69	15.20	18.92	15.93	-0.242046152618154	4.51899806186836	0.0150844062080317	0.148402100149332	17:1742835-1755268:+	SERPINF2	33;GO:0002020,molecular_function protease binding;GO:0002034,biological_process regulation of blood vessel size by renin-angiotensin;GO:0002576,biological_process platelet degranulation;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005577,cellular_component fibrinogen complex;GO:0005615,cellular_component extracellular space;GO:0006953,biological_process acute-phase response;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010757,biological_process negative regulation of plasminogen activation;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030199,biological_process collagen fibril organization;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031093,cellular_component platelet alpha granule lumen;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0042730,biological_process fibrinolysis;GO:0042803,molecular_function protein homodimerization activity;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048514,biological_process blood vessel morphogenesis;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051918,biological_process negative regulation of fibrinolysis;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071636,biological_process positive regulation of transforming growth factor beta production;GO:0072562,cellular_component blood microparticle;GO:2000049,biological_process positive regulation of cell-cell adhesion mediated by cadherin	SERPINF2, AAP; alpha-2-antiplasmin; K03983	serpin family F member 2 [Source:HGNC Symbol%3BAcc:HGNC:9075]
ENSG00000092421	21.55	24.03	21.51	23.79	30.56	24.57	-0.223952105210909	6.27786035325708	0.0150888816798783	0.148402100149332	5:116443615-116574934:-	SEMA6A	20;GO:0001764,biological_process neuron migration;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007010,biological_process cytoskeleton organization;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030215,molecular_function semaphorin receptor binding;GO:0030424,cellular_component axon;GO:0051642,biological_process centrosome localization;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:2001224,biological_process positive regulation of neuron migration	SEMA6; semaphorin 6; K06842	semaphorin 6A [Source:HGNC Symbol%3BAcc:HGNC:10738]
ENSG00000215375	23.47	18.97	18.04	15.88	15.74	17.66	0.311323301104538	3.62442368200229	0.0150932170446283	0.148402100149332	4:673579-682033:+	MYL5	8;GO:0005509,molecular_function calcium ion binding;GO:0005829,cellular_component cytosol;GO:0005859,cellular_component muscle myosin complex;GO:0006936,biological_process muscle contraction;GO:0006937,biological_process regulation of muscle contraction;GO:0008307,molecular_function structural constituent of muscle;GO:0016459,cellular_component myosin complex;GO:0046872,molecular_function metal ion binding	MYL5; myosin regulatory light chain 5; K12753	myosin light chain 5 [Source:HGNC Symbol%3BAcc:HGNC:7586]
ENSG00000164405	267.00	254.45	234.27	276.05	298.13	283.56	-0.170923849808608	6.05242018535462	0.0150996417053578	0.148402100149332	5:132866559-132868031:+	UQCRQ	17;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0016020,cellular_component membrane;GO:0021539,biological_process subthalamus development;GO:0021548,biological_process pons development;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0021766,biological_process hippocampus development;GO:0021794,biological_process thalamus development;GO:0021854,biological_process hypothalamus development;GO:0021860,biological_process pyramidal neuron development;GO:0030901,biological_process midbrain development;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	QCR8, UQCRQ; ubiquinol-cytochrome c reductase subunit 8; K00418	ubiquinol-cytochrome c reductase complex III subunit VII [Source:HGNC Symbol%3BAcc:HGNC:29594]
ENSG00000142731	12.62	11.95	10.37	13.17	14.26	13.17	-0.205080096318097	5.20281331416612	0.0151766753246441	0.149041195256968	4:127880860-127899195:+	PLK4	27;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0001741,cellular_component XY body;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007099,biological_process centriole replication;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032154,cellular_component cleavage furrow;GO:0042802,molecular_function identical protein binding;GO:0046601,biological_process positive regulation of centriole replication;GO:0060707,biological_process trophoblast giant cell differentiation;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0098535,biological_process de novo centriole assembly;GO:0098536,cellular_component deuterosome	PLK4; polo-like kinase 4 [EC:2.7.11.21]; K08863	polo like kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:11397]
ENSG00000183354	7.63	6.95	7.26	6.03	7.05	6.25	0.191007767823461	5.48618422343387	0.0152531068333871	0.149605210636149	9:5881595-6007901:-	KIAA2026	NA	NA	KIAA2026 [Source:HGNC Symbol%3BAcc:HGNC:23378]
ENSG00000122641	3.37	2.32	3.17	2.40	1.48	2.26	0.553186016923763	1.75156364813017	0.0152774968021413	0.149605210636149	7:41667167-41705834:-	INHBA	66;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0001541,biological_process ovarian follicle development;GO:0001707,biological_process mesoderm formation;GO:0001942,biological_process hair follicle development;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005179,molecular_function hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006952,biological_process defense response;GO:0007050,biological_process cell cycle arrest;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0008083,molecular_function growth factor activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0010628,biological_process positive regulation of gene expression;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0017046,molecular_function peptide hormone binding;GO:0021773,biological_process striatal medium spiny neuron differentiation;GO:0030154,biological_process cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032924,biological_process activin receptor signaling pathway;GO:0034711,molecular_function inhibin binding;GO:0035987,biological_process endodermal cell differentiation;GO:0042326,biological_process negative regulation of phosphorylation;GO:0042476,biological_process odontogenesis;GO:0042493,biological_process response to drug;GO:0042541,biological_process hemoglobin biosynthetic process;GO:0042701,biological_process progesterone secretion;GO:0042802,molecular_function identical protein binding;GO:0043408,biological_process regulation of MAPK cascade;GO:0043509,cellular_component activin A complex;GO:0043512,cellular_component inhibin A complex;GO:0045077,biological_process negative regulation of interferon-gamma biosynthetic process;GO:0045578,biological_process negative regulation of B cell differentiation;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045650,biological_process negative regulation of macrophage differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046880,biological_process regulation of follicle-stimulating hormone secretion;GO:0046881,biological_process positive regulation of follicle-stimulating hormone secretion;GO:0046882,biological_process negative regulation of follicle-stimulating hormone secretion;GO:0046982,molecular_function protein heterodimerization activity;GO:0048333,biological_process mesodermal cell differentiation;GO:0048468,biological_process cell development;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051799,biological_process negative regulation of hair follicle development;GO:0060021,biological_process palate development;GO:0060279,biological_process positive regulation of ovulation;GO:0060395,biological_process SMAD protein signal transduction;GO:0061029,biological_process eyelid development in camera-type eye;GO:0070699,molecular_function type II activin receptor binding;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0071397,biological_process cellular response to cholesterol;GO:0097154,biological_process GABAergic neuron differentiation;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	INHBA; inhibin beta A chain; K04667	inhibin beta A subunit [Source:HGNC Symbol%3BAcc:HGNC:6066]
ENSG00000182544	11.67	11.27	11.06	8.74	11.17	8.42	0.27735593557811	4.12712296751616	0.0152783533714948	0.149605210636149	12:53251250-53254405:+	MFSD5	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015098,molecular_function molybdate ion transmembrane transporter activity;GO:0015689,biological_process molybdate ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	major facilitator superfamily domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:28156]
ENSG00000131508	143.68	136.67	124.25	163.43	145.00	153.94	-0.181156138868964	6.07496626273693	0.0152823174967081	0.149605210636149	5:139526430-139628433:+	UBE2D2	22;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043234,cellular_component protein complex;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051865,biological_process protein autoubiquitination;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070062,cellular_component extracellular exosome;GO:0070936,biological_process protein K48-linked ubiquitination	UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]; K06689	ubiquitin conjugating enzyme E2 D2 [Source:HGNC Symbol%3BAcc:HGNC:12475]
ENSG00000064012	40.32	39.19	37.75	46.68	41.35	44.63	-0.166482717009901	6.22478084705815	0.0153084832277144	0.149743264228226	2:201233442-201287711:+	CASP8	68;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005123,molecular_function death receptor binding;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0009409,biological_process response to cold;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0030101,biological_process natural killer cell activation;GO:0030225,biological_process macrophage differentiation;GO:0031264,cellular_component death-inducing signaling complex;GO:0031265,cellular_component CD95 death-inducing signaling complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032025,biological_process response to cobalt ion;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0034612,biological_process response to tumor necrosis factor;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0035877,molecular_function death effector domain binding;GO:0036462,biological_process TRAIL-activated apoptotic signaling pathway;GO:0039650,biological_process suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process;GO:0042110,biological_process T cell activation;GO:0042113,biological_process B cell activation;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043005,cellular_component neuron projection;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0044297,cellular_component cell body;GO:0045121,cellular_component membrane raft;GO:0045471,biological_process response to ethanol;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045862,biological_process positive regulation of proteolysis;GO:0046677,biological_process response to antibiotic;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0060544,biological_process regulation of necroptotic process;GO:0060715,biological_process syncytiotrophoblast cell differentiation involved in labyrinthine layer development;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071550,biological_process death-inducing signaling complex assembly;GO:0097110,molecular_function scaffold protein binding;GO:0097153,molecular_function cysteine-type endopeptidase activity involved in apoptotic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097194,biological_process execution phase of apoptosis;GO:0097199,molecular_function cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097342,cellular_component ripoptosome;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	CASP8; caspase 8 [EC:3.4.22.61]; K04398	caspase 8 [Source:HGNC Symbol%3BAcc:HGNC:1509]
ENSG00000135124	47.91	46.02	52.46	45.76	42.23	42.87	0.176047898152478	5.85706806190734	0.0153544520082874	0.150074655731395	12:121209856-121234106:+	P2RX4	58;GO:0001614,molecular_function purinergic nucleotide receptor activity;GO:0001894,biological_process tissue homeostasis;GO:0002028,biological_process regulation of sodium ion transport;GO:0004931,molecular_function extracellular ATP-gated cation channel activity;GO:0005102,molecular_function receptor binding;GO:0005216,molecular_function ion channel activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0008144,molecular_function drug binding;GO:0008217,biological_process regulation of blood pressure;GO:0008270,molecular_function zinc ion binding;GO:0010524,biological_process positive regulation of calcium ion transport into cytosol;GO:0010614,biological_process negative regulation of cardiac muscle hypertrophy;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019228,biological_process neuronal action potential;GO:0019233,biological_process sensory perception of pain;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0032308,biological_process positive regulation of prostaglandin secretion;GO:0033198,biological_process response to ATP;GO:0034220,biological_process ion transmembrane transport;GO:0034405,biological_process response to fluid shear stress;GO:0035590,biological_process purinergic nucleotide receptor signaling pathway;GO:0042118,biological_process endothelial cell activation;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0043195,cellular_component terminal bouton;GO:0043197,cellular_component dendritic spine;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050850,biological_process positive regulation of calcium-mediated signaling;GO:0051260,biological_process protein homooligomerization;GO:0051899,biological_process membrane depolarization;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060079,biological_process excitatory postsynaptic potential;GO:0070062,cellular_component extracellular exosome;GO:0071318,biological_process cellular response to ATP;GO:0097190,biological_process apoptotic signaling pathway;GO:0098655,biological_process cation transmembrane transport;GO:0098794,cellular_component postsynapse;GO:2001028,biological_process positive regulation of endothelial cell chemotaxis	P2RX4; P2X purinoceptor 4; K05218	purinergic receptor P2X 4 [Source:HGNC Symbol%3BAcc:HGNC:8535]
ENSG00000076716	52.72	63.14	53.83	46.41	54.38	47.43	0.204592222034413	6.46646604922113	0.0154030686970635	0.150364291147718	X:133300102-133415490:-	GPC4	21;GO:0001523,biological_process retinoid metabolic process;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008283,biological_process cell proliferation;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0031225,cellular_component anchored component of membrane;GO:0043202,cellular_component lysosomal lumen;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0070062,cellular_component extracellular exosome;GO:1904929,molecular_function coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	GPC4; glypican 4; K08110	glypican 4 [Source:HGNC Symbol%3BAcc:HGNC:4452]
ENSG00000113368	66.01	72.19	55.31	72.55	82.73	72.22	-0.223181517569251	6.98812252435172	0.0154110324832504	0.150364291147718	5:126776622-126837020:+	LMNB1	13;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005638,cellular_component lamin filament;GO:0005654,cellular_component nucleoplasm;GO:0005882,cellular_component intermediate filament;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0031965,cellular_component nuclear membrane;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043274,molecular_function phospholipase binding	LMNB; lamin B; K07611	lamin B1 [Source:HGNC Symbol%3BAcc:HGNC:6637]
ENSG00000006282	46.87	43.07	44.85	40.46	37.68	42.98	0.166770160936033	6.84261584740794	0.0154291192305804	0.150364291147718	17:50543057-50555852:+	SPATA20	5;GO:0003824,molecular_function catalytic activity;GO:0005576,cellular_component extracellular region;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation	NA	spermatogenesis associated 20 [Source:HGNC Symbol%3BAcc:HGNC:26125]
ENSG00000048140	28.94	31.68	27.58	33.02	36.73	32.37	-0.203845979610642	5.11263027784395	0.0154325390253922	0.150364291147718	5:176647386-176659054:+	TSPAN17	9;GO:0000151,cellular_component ubiquitin ligase complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0019899,molecular_function enzyme binding;GO:0072594,biological_process establishment of protein localization to organelle	NA	tetraspanin 17 [Source:HGNC Symbol%3BAcc:HGNC:13594]
ENSG00000135048	20.02	24.51	18.77	16.61	20.11	17.31	0.237926281287666	6.37706383120632	0.0154518659602343	0.150434519344618	9:71683365-71816690:-	TMEM2	15;GO:0001525,biological_process angiogenesis;GO:0004415,molecular_function hyalurononglucosaminidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030214,biological_process hyaluronan catabolic process;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:1903670,biological_process regulation of sprouting angiogenesis	NA	transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11869]
ENSG00000139116	16.42	15.94	14.66	16.20	19.00	18.67	-0.184909453509492	6.41502642646879	0.0154951505252532	0.150737698644175	12:39293227-39443390:-	KIF21A	12;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity	NA	kinesin family member 21A [Source:HGNC Symbol%3BAcc:HGNC:19349]
ENSG00000081019	5.58	5.92	5.63	5.01	5.08	4.09	0.283590436237486	3.6618855699613	0.0155099480585934	0.150763496672921	1:113761831-113812476:-	RSBN1	1;GO:0005634,cellular_component nucleus	NA	round spermatid basic protein 1 [Source:HGNC Symbol%3BAcc:HGNC:25642]
ENSG00000071054	60.39	58.56	61.48	70.79	63.10	68.74	-0.155299937168231	8.0677755363678	0.0155362306231247	0.150900806513965	2:101696849-101894689:+	MAP4K4	22;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0004111,molecular_function creatine kinase activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046328,biological_process regulation of JNK cascade;GO:0048812,biological_process neuron projection morphogenesis;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070571,biological_process negative regulation of neuron projection regeneration	MAP4K4, HGK; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]; K04407	mitogen-activated protein kinase kinase kinase kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:6866]
ENSG00000154760	0.89	0.85	0.98	0.56	0.54	0.71	0.611959648189175	1.12370713049864	0.0155707075684583	0.151117430060417	17:35435095-35448837:-	SLFN13	3;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular	NA	schlafen family member 13 [Source:HGNC Symbol%3BAcc:HGNC:26481]
ENSG00000100612	52.93	54.31	54.19	49.00	48.42	49.26	0.149250025163593	6.13880626384631	0.0156136506947197	0.151415817244965	14:60144119-60169856:-	DHRS7	3;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	dehydrogenase/reductase 7 [Source:HGNC Symbol%3BAcc:HGNC:21524]
ENSG00000146243	6.63	7.56	6.37	5.45	4.56	5.79	0.37850819794191	2.55092326087148	0.0156585356057903	0.151732554625039	6:78867471-78946440:+	IRAK1BP1	8;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006955,biological_process immune response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling	NA	interleukin 1 receptor associated kinase 1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17368]
ENSG00000185946	9.74	11.21	10.30	8.50	9.54	8.25	0.256236485228104	3.90335965867364	0.0157364533074134	0.152368638771391	1:103525690-103555239:+	RNPC3	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030626,molecular_function U12 snRNA binding;GO:0032502,biological_process developmental process;GO:0097157,molecular_function pre-mRNA intronic binding	NA	RNA binding region (RNP1%2C RRM) containing 3 [Source:HGNC Symbol%3BAcc:HGNC:18666]
ENSG00000112773	17.27	16.96	17.45	15.31	12.67	16.41	0.229806157389664	4.71309802226934	0.0158006418439758	0.152839329265652	6:81491438-81752774:-	FAM46A	4;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0010468,biological_process regulation of gene expression;GO:0030193,biological_process regulation of blood coagulation	NA	family with sequence similarity 46 member A [Source:HGNC Symbol%3BAcc:HGNC:18345]
ENSG00000125746	12.26	11.74	13.04	12.07	8.78	10.75	0.242482237226221	5.27513042974388	0.0158096913539915	0.152839329265652	19:45606993-45645629:-	EML2	17;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0007601,biological_process visual perception;GO:0007605,biological_process sensory perception of sound;GO:0008017,molecular_function microtubule binding;GO:0008022,molecular_function protein C-terminus binding;GO:0010968,biological_process regulation of microtubule nucleation;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0072686,cellular_component mitotic spindle	NA	echinoderm microtubule associated protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:18035]
ENSG00000040531	17.90	19.37	18.39	15.67	16.99	16.01	0.201629732514372	4.56705791100448	0.0158337780524709	0.152953063786243	17:3636467-3661542:+	CTNS	29;GO:0002088,biological_process lens development in camera-type eye;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006749,biological_process glutathione metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007420,biological_process brain development;GO:0007616,biological_process long-term memory;GO:0007625,biological_process grooming behavior;GO:0007628,biological_process adult walking behavior;GO:0008542,biological_process visual learning;GO:0010730,biological_process negative regulation of hydrogen peroxide biosynthetic process;GO:0010918,biological_process positive regulation of mitochondrial membrane potential;GO:0015184,molecular_function L-cystine transmembrane transporter activity;GO:0015811,biological_process L-cystine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042438,biological_process melanin biosynthetic process;GO:0042470,cellular_component melanosome;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0046034,biological_process ATP metabolic process;GO:0050890,biological_process cognition;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1903427,biological_process negative regulation of reactive oxygen species biosynthetic process	CTNS; cystinosin; K12386	cystinosin%2C lysosomal cystine transporter [Source:HGNC Symbol%3BAcc:HGNC:2518]
ENSG00000033627	17.41	17.17	17.05	14.48	16.20	15.60	0.169553607419074	5.50152702305441	0.0158523998852508	0.153013872298303	17:42458843-42522611:+	ATP6V0A1	38;GO:0000220,cellular_component vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007035,biological_process vacuolar acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0016607,cellular_component nuclear speck;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0042470,cellular_component melanosome;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly;GO:0090383,biological_process phagosome acidification;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1901998,biological_process toxin transport	ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a; K02154	ATPase H+ transporting V0 subunit a1 [Source:HGNC Symbol%3BAcc:HGNC:865]
ENSG00000131374	23.48	23.44	24.38	25.88	26.71	27.32	-0.152540874405285	5.97035087297413	0.0158767515901802	0.153032388430989	3:17157161-18444817:-	TBC1D5	26;GO:0002092,biological_process positive regulation of receptor internalization;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006914,biological_process autophagy;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0017137,molecular_function Rab GTPase binding;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030904,cellular_component retromer complex;GO:0031338,biological_process regulation of vesicle fusion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035612,molecular_function AP-2 adaptor complex binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042594,biological_process response to starvation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0090630,biological_process activation of GTPase activity;GO:1905394,molecular_function retromer complex binding;GO:1990316,cellular_component ATG1/ULK1 kinase complex	NA	TBC1 domain family member 5 [Source:HGNC Symbol%3BAcc:HGNC:19166]
ENSG00000186166	15.82	14.89	13.36	12.90	13.14	10.43	0.286296072472897	3.87603810833762	0.0158789749697183	0.153032388430989	11:118998141-119015791:+	CCDC84	NA	NA	coiled-coil domain containing 84 [Source:HGNC Symbol%3BAcc:HGNC:30460]
ENSG00000164949	15.43	15.07	17.65	13.49	11.36	14.73	0.295640761826317	3.71669779061832	0.0159089845426556	0.153137773817499	8:94249252-94262350:-	GEM	21;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000287,molecular_function magnesium ion binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030496,cellular_component midbody;GO:0051233,cellular_component spindle midzone;GO:0051276,biological_process chromosome organization;GO:0051310,biological_process metaphase plate congression;GO:0072686,cellular_component mitotic spindle;GO:1901842,biological_process negative regulation of high voltage-gated calcium channel activity	NA	GTP binding protein overexpressed in skeletal muscle [Source:HGNC Symbol%3BAcc:HGNC:4234]
ENSG00000120963	241.16	254.06	255.68	303.14	264.00	283.97	-0.169883559421642	6.26391136690852	0.0159145837609421	0.153137773817499	8:101177877-101206193:-	ZNF706	6;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006417,biological_process regulation of translation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:1902455,biological_process negative regulation of stem cell population maintenance	NA	zinc finger protein 706 [Source:HGNC Symbol%3BAcc:HGNC:24992]
ENSG00000073536	8.80	8.69	8.66	10.52	9.59	11.04	-0.242412692564628	3.92763959958029	0.0159383302313201	0.153247477274498	17:35128752-35142315:-	NLE1	14;GO:0000027,biological_process ribosomal large subunit assembly;GO:0001756,biological_process somitogenesis;GO:0001822,biological_process kidney development;GO:0001826,biological_process inner cell mass cell differentiation;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005840,cellular_component ribosome;GO:0007219,biological_process Notch signaling pathway;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0048705,biological_process skeletal system morphogenesis;GO:0061484,biological_process hematopoietic stem cell homeostasis;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:2001268,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	NA	notchless homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:19889]
ENSG00000117155	10.10	9.59	9.62	11.38	10.96	11.74	-0.204606776845869	4.42450845064528	0.0160160776987475	0.153861386278159	1:84643706-84690803:-	SSX2IP	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0007098,biological_process centrosome cycle;GO:0007155,biological_process cell adhesion;GO:0019904,molecular_function protein domain specific binding;GO:0030030,biological_process cell projection organization;GO:0030054,cellular_component cell junction;GO:0031252,cellular_component cell leading edge;GO:0034451,cellular_component centriolar satellite;GO:0035020,biological_process regulation of Rac protein signal transduction;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0060271,biological_process cilium morphogenesis;GO:2000145,biological_process regulation of cell motility	SSX2IP, ADIP; synovial sarcoma, X breakpoint 2 interacting protein; K06085	SSX family member 2 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16509]
ENSG00000215252	2.22	1.66	2.39	2.68	2.61	3.30	-0.425430147798737	2.41506368010678	0.0160363747448177	0.153861386278159	15:34525206-34588503:-	GOLGA8B	4;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0032580,cellular_component Golgi cisterna membrane	NA	golgin A8 family member B [Source:HGNC Symbol%3BAcc:HGNC:31973]
ENSG00000183091	0.19	0.19	0.21	0.15	0.17	0.12	0.436734726826299	2.18232571283148	0.0160491031615596	0.153861386278159	2:151485335-151734487:-	NEB	16;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007517,biological_process muscle organ development;GO:0007525,biological_process somatic muscle development;GO:0008307,molecular_function structural constituent of muscle;GO:0015629,cellular_component actin cytoskeleton;GO:0030016,cellular_component myofibril;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030049,biological_process muscle filament sliding;GO:0030832,biological_process regulation of actin filament length;GO:0043292,cellular_component contractile fiber;GO:0070062,cellular_component extracellular exosome	NA	nebulin [Source:HGNC Symbol%3BAcc:HGNC:7720]
ENSG00000184900	47.85	49.73	46.27	45.45	40.80	40.88	0.187875396072807	5.06372630266423	0.0160591676510171	0.153861386278159	21:44805616-44818779:-	SUMO3	12;GO:0000776,cellular_component kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0016605,cellular_component PML body;GO:0016925,biological_process protein sumoylation;GO:0019899,molecular_function enzyme binding;GO:0031386,molecular_function protein tag;GO:0043392,biological_process negative regulation of DNA binding;GO:0070062,cellular_component extracellular exosome;GO:0070911,biological_process global genome nucleotide-excision repair	SUMO, SMT3; small ubiquitin-related modifier; K12160	small ubiquitin-like modifier 3 [Source:HGNC Symbol%3BAcc:HGNC:11124]
ENSG00000196313	13.08	12.76	12.54	11.11	11.67	11.83	0.160610423178228	5.56822488147773	0.0160746195315325	0.153861386278159	7:72879364-72951440:+	POM121	29;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006110,biological_process regulation of glycolytic process;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008139,molecular_function nuclear localization sequence binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	POM121, NUP121; nuclear pore complex protein Nup121; K14316	POM121 transmembrane nucleoporin [Source:HGNC Symbol%3BAcc:HGNC:19702]
ENSG00000164087	16.49	19.49	17.00	20.54	22.86	19.35	-0.238676477043041	4.5656542244392	0.0160765502298213	0.153861386278159	3:52075252-52154690:-	POC1A	15;GO:0000922,cellular_component spindle pole;GO:0003431,biological_process growth plate cartilage chondrocyte development;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0007052,biological_process mitotic spindle organization;GO:0007283,biological_process spermatogenesis;GO:0010825,biological_process positive regulation of centrosome duplication;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060348,biological_process bone development;GO:1905515,biological_process non-motile cilium assembly	NA	POC1 centriolar protein A [Source:HGNC Symbol%3BAcc:HGNC:24488]
ENSG00000069345	64.53	64.17	66.83	72.94	71.74	74.18	-0.150441376509468	6.4231609829431	0.0161127504409694	0.154089037922768	16:46955361-46973788:-	DNAJA2	15;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009408,biological_process response to heat;GO:0016020,cellular_component membrane;GO:0031072,molecular_function heat shock protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0042026,biological_process protein refolding;GO:0046872,molecular_function metal ion binding;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0070062,cellular_component extracellular exosome	DNAJA2; DnaJ homolog subfamily A member 2; K09503	DnaJ heat shock protein family (Hsp40) member A2 [Source:HGNC Symbol%3BAcc:HGNC:14884]
ENSG00000004399	9.66	10.39	10.18	8.77	9.37	9.10	0.159918423487139	5.80944842761841	0.0161350971328158	0.154183957436214	3:129555174-129606818:-	PLXND1	27;GO:0001525,biological_process angiogenesis;GO:0001569,biological_process patterning of blood vessels;GO:0003151,biological_process outflow tract morphogenesis;GO:0003279,biological_process cardiac septum development;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007416,biological_process synapse assembly;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0019904,molecular_function protein domain specific binding;GO:0030027,cellular_component lamellipodium;GO:0030334,biological_process regulation of cell migration;GO:0032092,biological_process positive regulation of protein binding;GO:0035904,biological_process aorta development;GO:0043087,biological_process regulation of GTPase activity;GO:0043542,biological_process endothelial cell migration;GO:0045765,biological_process regulation of angiogenesis;GO:0050772,biological_process positive regulation of axonogenesis;GO:0060666,biological_process dichotomous subdivision of terminal units involved in salivary gland branching;GO:0060976,biological_process coronary vasculature development;GO:0071526,biological_process semaphorin-plexin signaling pathway	NA	plexin D1 [Source:HGNC Symbol%3BAcc:HGNC:9107]
ENSG00000131067	26.80	25.44	28.10	24.50	23.41	24.52	0.163609319308654	5.77657313091413	0.0161843663726836	0.15453579983394	20:34844719-34872860:-	GGT7	14;GO:0005515,molecular_function protein binding;GO:0006508,biological_process proteolysis;GO:0006749,biological_process glutathione metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0006751,biological_process glutathione catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016787,molecular_function hydrolase activity;GO:0036374,molecular_function glutathione hydrolase activity;GO:0102953,molecular_function hypoglycin A gamma-glutamyl transpeptidase activity;GO:1901750,biological_process leukotriene D4 biosynthetic process;GO:1902883,biological_process negative regulation of response to oxidative stress	ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]; K00681	gamma-glutamyltransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:4259]
ENSG00000105926	33.12	36.87	31.18	36.83	44.45	36.77	-0.213392866598323	5.99531587497902	0.0162255142021406	0.154809613982453	7:24573267-24694193:+	MPP6	6;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0016020,cellular_component membrane;GO:0030165,molecular_function PDZ domain binding;GO:0070062,cellular_component extracellular exosome	NA	membrane palmitoylated protein 6 [Source:HGNC Symbol%3BAcc:HGNC:18167]
ENSG00000184743	28.23	27.29	25.15	29.92	29.93	31.50	-0.168579614680455	5.67851332579084	0.0162555259463473	0.154898093169501	11:63624086-63671921:-	ATL3	14;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0051260,biological_process protein homooligomerization;GO:0071782,cellular_component endoplasmic reticulum tubular network	NA	atlastin GTPase 3 [Source:HGNC Symbol%3BAcc:HGNC:24526]
ENSG00000165475	33.68	28.42	33.14	29.10	26.29	27.84	0.212598149590809	4.86857591700621	0.0162597450575896	0.154898093169501	13:20403666-20525857:-	CRYL1	11;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006631,biological_process fatty acid metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0019640,biological_process glucuronate catabolic process to xylulose 5-phosphate;GO:0042803,molecular_function protein homodimerization activity;GO:0050104,molecular_function L-gulonate 3-dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070403,molecular_function NAD+ binding	CRYL1; L-gulonate 3-dehydrogenase [EC:1.1.1.45]; K13247	crystallin lambda 1 [Source:HGNC Symbol%3BAcc:HGNC:18246]
ENSG00000120675	38.77	36.95	36.96	30.28	32.70	33.75	0.232639628639904	3.98681271715311	0.0163021576224922	0.155183038779137	13:43023202-43114224:+	DNAJC15	11;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0009267,biological_process cellular response to starvation;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0031333,biological_process negative regulation of protein complex assembly;GO:1902957,biological_process negative regulation of mitochondrial electron transport, NADH to ubiquinone	NA	DnaJ heat shock protein family (Hsp40) member C15 [Source:HGNC Symbol%3BAcc:HGNC:20325]
ENSG00000121753	2.20	2.14	2.35	2.04	1.70	1.75	0.301574135317931	3.33845497367578	0.0163278136192181	0.155244226989534	1:31727116-31764893:-	ADGRB2	12;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007422,biological_process peripheral nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0051965,biological_process positive regulation of synapse assembly	NA	adhesion G protein-coupled receptor B2 [Source:HGNC Symbol%3BAcc:HGNC:944]
ENSG00000128596	3.91	3.29	3.18	3.14	2.69	2.68	0.303366387691801	3.56952949556494	0.0163335986826981	0.155244226989534	7:128790756-128822132:+	CCDC136	8;GO:0001675,biological_process acrosome assembly;GO:0002080,cellular_component acrosomal membrane;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle	NA	coiled-coil domain containing 136 [Source:HGNC Symbol%3BAcc:HGNC:22225]
ENSG00000071242	9.53	8.04	9.29	11.30	9.92	10.47	-0.219511960680954	4.57933289810228	0.0163535317734671	0.155314758916639	6:166409363-166906451:-	RPS6KA2	34;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001556,biological_process oocyte maturation;GO:0002035,biological_process brain renin-angiotensin system;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004711,molecular_function ribosomal protein S6 kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007507,biological_process heart development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010659,biological_process cardiac muscle cell apoptotic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045786,biological_process negative regulation of cell cycle;GO:0045835,biological_process negative regulation of meiotic nuclear division;GO:0046872,molecular_function metal ion binding;GO:0060047,biological_process heart contraction;GO:0070613,biological_process regulation of protein processing;GO:0071322,biological_process cellular response to carbohydrate stimulus	RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]; K04373	ribosomal protein S6 kinase A2 [Source:HGNC Symbol%3BAcc:HGNC:10431]
ENSG00000132026	0.61	1.24	1.27	0.57	0.25	0.61	1.09613688053171	-0.257520764385873	0.0163825260426243	0.155463488946501	19:12825477-12835428:-	RTBDN	7;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0033165,cellular_component interphotoreceptor matrix;GO:1902444,molecular_function riboflavin binding	NA	retbindin [Source:HGNC Symbol%3BAcc:HGNC:30310]
ENSG00000088812	28.76	28.26	27.97	25.38	26.11	25.92	0.1466764716594	6.86604146567144	0.0163942404761918	0.155463488946501	20:3471039-3651122:+	ATRN	16;GO:0004872,molecular_function receptor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006979,biological_process response to oxidative stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021549,biological_process cerebellum development;GO:0030246,molecular_function carbohydrate binding;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042552,biological_process myelination;GO:0043473,biological_process pigmentation;GO:0070062,cellular_component extracellular exosome	NA	attractin [Source:HGNC Symbol%3BAcc:HGNC:885]
ENSG00000135049	18.83	16.71	20.14	22.23	19.40	22.70	-0.193940547757954	6.27905439715609	0.0164167088069125	0.155557714824584	9:85546538-85742029:-	AGTPBP1	27;GO:0001754,biological_process eye photoreceptor cell differentiation;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0007005,biological_process mitochondrion organization;GO:0007628,biological_process adult walking behavior;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0015631,molecular_function tubulin binding;GO:0016787,molecular_function hydrolase activity;GO:0021549,biological_process cerebellum development;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0021702,biological_process cerebellar Purkinje cell differentiation;GO:0021772,biological_process olfactory bulb development;GO:0035609,biological_process C-terminal protein deglutamylation;GO:0035610,biological_process protein side chain deglutamylation;GO:0042133,biological_process neurotransmitter metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0050905,biological_process neuromuscular process;GO:0060041,biological_process retina development in camera-type eye	NA	ATP/GTP binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17258]
ENSG00000174547	63.30	61.84	62.89	71.05	70.44	70.54	-0.160533863664505	5.43583391295645	0.0164308576282329	0.155565136463746	11:66435074-66466738:-	MRPL11	14;GO:0000027,biological_process ribosomal large subunit assembly;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0019843,molecular_function rRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L11, MRPL11, rplK; large subunit ribosomal protein L11; K02867	mitochondrial ribosomal protein L11 [Source:HGNC Symbol%3BAcc:HGNC:14042]
ENSG00000164402	24.72	25.07	24.53	26.85	27.95	29.30	-0.16802886332807	5.42551351158525	0.0164425569193938	0.155565136463746	5:132750816-132807241:-	SEPT8	5;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton	SEPT6_8_11; septin 6/8/11; K16939	septin 8 [Source:HGNC Symbol%3BAcc:HGNC:16511]
ENSG00000183454	1.45	1.39	1.44	1.00	1.10	1.23	0.367353640808378	2.51786096216433	0.0164770952261116	0.155746520027793	16:9753403-10182754:-	GRIN2A	66;GO:0000165,biological_process MAPK cascade;GO:0001964,biological_process startle response;GO:0001975,biological_process response to amphetamine;GO:0004872,molecular_function receptor activity;GO:0004970,molecular_function ionotropic glutamate receptor activity;GO:0004972,molecular_function NMDA glutamate receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005216,molecular_function ion channel activity;GO:0005234,molecular_function extracellular-glutamate-gated ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007215,biological_process glutamate receptor signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0007611,biological_process learning or memory;GO:0007612,biological_process learning;GO:0007613,biological_process memory;GO:0008021,cellular_component synaptic vesicle;GO:0008104,biological_process protein localization;GO:0008270,molecular_function zinc ion binding;GO:0008542,biological_process visual learning;GO:0009611,biological_process response to wounding;GO:0009986,cellular_component cell surface;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017146,cellular_component NMDA selective glutamate receptor complex;GO:0019233,biological_process sensory perception of pain;GO:0022008,biological_process neurogenesis;GO:0030054,cellular_component cell junction;GO:0030431,biological_process sleep;GO:0033058,biological_process directional locomotion;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0040011,biological_process locomotion;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042391,biological_process regulation of membrane potential;GO:0042417,biological_process dopamine metabolic process;GO:0042428,biological_process serotonin metabolic process;GO:0042493,biological_process response to drug;GO:0042734,cellular_component presynaptic membrane;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0048167,biological_process regulation of synaptic plasticity;GO:0050804,biological_process modulation of synaptic transmission;GO:0051930,biological_process regulation of sensory perception of pain;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060291,biological_process long-term synaptic potentiation;GO:0070588,biological_process calcium ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport;GO:0098839,cellular_component postsynaptic density membrane;GO:0099061,cellular_component integral component of postsynaptic density membrane;GO:1900273,biological_process positive regulation of long-term synaptic potentiation	GRIN2A; glutamate receptor ionotropic, NMDA 2A; K05209	glutamate ionotropic receptor NMDA type subunit 2A [Source:HGNC Symbol%3BAcc:HGNC:4585]
ENSG00000074054	17.39	16.06	17.37	18.24	20.17	19.00	-0.161734509205771	6.43421439928796	0.0164887784568697	0.155746520027793	2:121337775-121649587:-	CLASP1	62;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001578,biological_process microtubule bundle formation;GO:0002162,molecular_function dystroglycan binding;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005828,cellular_component kinetochore microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006903,biological_process vesicle targeting;GO:0007020,biological_process microtubule nucleation;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007030,biological_process Golgi organization;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0008017,molecular_function microtubule binding;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010458,biological_process exit from mitosis;GO:0010470,biological_process regulation of gastrulation;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0030953,biological_process astral microtubule organization;GO:0030981,cellular_component cortical microtubule cytoskeleton;GO:0031023,biological_process microtubule organizing center organization;GO:0031111,biological_process negative regulation of microtubule polymerization or depolymerization;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031592,cellular_component centrosomal corona;GO:0034453,biological_process microtubule anchoring;GO:0035371,cellular_component microtubule plus-end;GO:0040001,biological_process establishment of mitotic spindle localization;GO:0043515,molecular_function kinetochore binding;GO:0045180,cellular_component basal cortex;GO:0045921,biological_process positive regulation of exocytosis;GO:0051010,molecular_function microtubule plus-end binding;GO:0051294,biological_process establishment of spindle orientation;GO:0051301,biological_process cell division;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0070062,cellular_component extracellular exosome;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0090091,biological_process positive regulation of extracellular matrix disassembly;GO:0090162,biological_process establishment of epithelial cell polarity;GO:0090307,biological_process mitotic spindle assembly;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1903690,biological_process negative regulation of wound healing, spreading of epidermal cells;GO:1904261,biological_process positive regulation of basement membrane assembly involved in embryonic body morphogenesis	NA	cytoplasmic linker associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17088]
ENSG00000113811	96.92	92.18	85.87	71.15	77.73	87.77	0.226678254894439	4.59659801359962	0.0165057156891081	0.155746520027793	3:53884409-53891988:-	SELENOK	27;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006979,biological_process response to oxidative stress;GO:0010742,biological_process macrophage derived foam cell differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018345,biological_process protein palmitoylation;GO:0030335,biological_process positive regulation of cell migration;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0045728,biological_process respiratory burst after phagocytosis;GO:0050848,biological_process regulation of calcium-mediated signaling;GO:0051223,biological_process regulation of protein transport;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071639,biological_process positive regulation of monocyte chemotactic protein-1 production;GO:0090197,biological_process positive regulation of chemokine secretion;GO:2000406,biological_process positive regulation of T cell migration;GO:2000778,biological_process positive regulation of interleukin-6 secretion	NA	selenoprotein K [Source:HGNC Symbol%3BAcc:HGNC:30394]
ENSG00000128595	219.47	233.45	220.74	197.38	218.01	190.40	0.164584446576622	7.95577359780997	0.016523389486538	0.155746520027793	7:128739291-128771807:+	CALU	15;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0033018,cellular_component sarcoplasmic reticulum lumen;GO:0042470,cellular_component melanosome;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding	NA	calumenin [Source:HGNC Symbol%3BAcc:HGNC:1458]
ENSG00000105011	25.46	28.85	27.90	30.10	32.12	34.30	-0.225719976815299	4.39183974451463	0.0165244636169019	0.155746520027793	19:14119508-14136956:-	ASF1B	17;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006333,biological_process chromatin assembly or disassembly;GO:0006334,biological_process nucleosome assembly;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016569,biological_process covalent chromatin modification;GO:0030154,biological_process cell differentiation;GO:0042393,molecular_function histone binding;GO:0043234,cellular_component protein complex	NA	anti-silencing function 1B histone chaperone [Source:HGNC Symbol%3BAcc:HGNC:20996]
ENSG00000129675	24.09	22.87	23.84	26.08	25.87	27.58	-0.154732882655168	5.87205353836899	0.0165514812999644	0.155882805293215	X:136665546-136782088:-	ARHGEF6	15;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007254,biological_process JNK cascade;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	ARHGEF6, PIXA; Rho guanine nucleotide exchange factor 6; K05729	Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:HGNC Symbol%3BAcc:HGNC:685]
ENSG00000179397	0.44	0.43	0.41	0.31	0.11	0.24	0.949420592974519	0.107034168292072	0.0165655422424527	0.15589694909444	1:244454376-244641177:+	CATSPERE	6;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036128,cellular_component CatSper complex;GO:0042995,cellular_component cell projection;GO:0097228,cellular_component sperm principal piece	NA	catsper channel auxiliary subunit epsilon [Source:HGNC Symbol%3BAcc:HGNC:28491]
ENSG00000204569	20.21	22.64	22.63	25.01	25.68	23.61	-0.172451008255668	6.04174428958481	0.0166020846039329	0.155904708695304	6:30600399-30618612:-	PPP1R10	13;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006606,biological_process protein import into nucleus;GO:0016604,cellular_component nuclear body;GO:0043086,biological_process negative regulation of catalytic activity;GO:0046872,molecular_function metal ion binding;GO:0072357,cellular_component PTW/PP1 phosphatase complex	NA	protein phosphatase 1 regulatory subunit 10 [Source:HGNC Symbol%3BAcc:HGNC:9284]
ENSG00000136859	0.38	0.19	0.35	0.81	0.46	0.71	-1.03540810891921	-0.174376711768186	0.0166039486409739	0.155904708695304	9:127087331-127122883:-	ANGPTL2	5;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0070062,cellular_component extracellular exosome	NA	angiopoietin like 2 [Source:HGNC Symbol%3BAcc:HGNC:490]
ENSG00000127995	17.28	16.75	17.21	14.69	14.94	16.23	0.171880131190801	5.28029701944636	0.0166040461528391	0.155904708695304	7:94509218-94557019:+	CASD1	9;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030173,cellular_component integral component of Golgi membrane;GO:0047186,molecular_function N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity	NA	CAS1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16014]
ENSG00000163319	70.96	70.22	70.49	88.23	74.24	82.20	-0.197392222862564	5.02717006993252	0.0166313856998111	0.156022545508649	4:83455931-83469735:+	MRPS18C	12;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18; K02963	mitochondrial ribosomal protein S18C [Source:HGNC Symbol%3BAcc:HGNC:16633]
ENSG00000133740	23.58	20.56	23.35	26.55	24.69	26.98	-0.195487093412923	4.88242028440451	0.0166417344923428	0.156022545508649	8:85177224-85217158:+	E2F5	19;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0051726,biological_process regulation of cell cycle	E2F4_5; transcription factor E2F4/5; K04682	E2F transcription factor 5 [Source:HGNC Symbol%3BAcc:HGNC:3119]
ENSG00000089177	5.06	5.40	5.80	4.92	4.26	4.99	0.208696904876682	4.95872087151569	0.0166553095171931	0.156031967575032	20:16272103-16573434:-	KIF16B	32;GO:0000166,molecular_function nucleotide binding;GO:0001704,biological_process formation of primary germ layer;GO:0001919,biological_process regulation of receptor recycling;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0007018,biological_process microtubule-based movement;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007492,biological_process endoderm development;GO:0008017,molecular_function microtubule binding;GO:0008289,molecular_function lipid binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031901,cellular_component early endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0032801,biological_process receptor catabolic process;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0045022,biological_process early endosome to late endosome transport;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	kinesin family member 16B [Source:HGNC Symbol%3BAcc:HGNC:15869]
ENSG00000243317	221.09	251.15	212.27	207.98	198.95	197.37	0.186597534949335	5.47674411498367	0.0167239592267561	0.156556942595569	7:135662495-135693418:+	C7orf73	4;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane	NA	chromosome 7 open reading frame 73 [Source:HGNC Symbol%3BAcc:HGNC:41909]
ENSG00000174327	8.07	8.45	6.68	6.09	6.17	6.44	0.314304964030484	3.17538524152435	0.0167458326665159	0.156643572637123	17:7036074-7040121:+	SLC16A13	11;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 16 member 13 [Source:HGNC Symbol%3BAcc:HGNC:31037]
ENSG00000197355	26.22	21.31	24.33	19.79	21.33	21.92	0.206083829050408	5.21858214116205	0.0167675247943904	0.156687544197103	9:137077500-137084539:+	UAP1L1	7;GO:0003977,molecular_function UDP-N-acetylglucosamine diphosphorylase activity;GO:0005829,cellular_component cytosol;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0070569,molecular_function uridylyltransferase activity	UAP1; UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase [EC:2.7.7.23 2.7.7.83]; K00972	UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:28082]
ENSG00000109618	3.08	2.87	2.92	4.62	3.22	3.94	-0.39620756293833	2.64691442444896	0.0167757791217232	0.156687544197103	4:25120013-25160442:-	SEPSECS	14;GO:0000049,molecular_function tRNA binding;GO:0001514,biological_process selenocysteine incorporation;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0016259,biological_process selenocysteine metabolic process;GO:0016740,molecular_function transferase activity;GO:0016785,molecular_function transferase activity, transferring selenium-containing groups;GO:0097056,biological_process selenocysteinyl-tRNA(Sec) biosynthetic process;GO:0098621,molecular_function phosphoseryl-selenocysteinyl-tRNA selenium transferase activity	SEPSECS; O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase [EC:2.9.1.2]; K03341	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [Source:HGNC Symbol%3BAcc:HGNC:30605]
ENSG00000104835	2.11	2.74	2.33	3.64	2.75	3.33	-0.44231087921184	2.31192849152483	0.0168034809851378	0.156736859598123	19:38915265-38930896:-	SARS2	13;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004828,molecular_function serine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006434,biological_process seryl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity;GO:0097056,biological_process selenocysteinyl-tRNA(Sec) biosynthetic process	SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]; K01875	seryl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:17697]
ENSG00000178202	7.71	7.90	7.77	6.15	6.82	6.75	0.256290322932555	3.58904643657535	0.0168084016937364	0.156736859598123	11:108472104-108498432:-	KDELC2	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006664,biological_process glycolipid metabolic process;GO:0008150,biological_process biological_process;GO:0046527,molecular_function glucosyltransferase activity	NA	KDEL motif containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28496]
ENSG00000086589	29.54	29.45	29.42	35.40	31.14	33.62	-0.168320633550723	5.72070264999326	0.0168298745529157	0.156736859598123	5:150690793-150701107:-	RBM22	26;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0017070,molecular_function U6 snRNA binding;GO:0033120,biological_process positive regulation of RNA splicing;GO:0035690,biological_process cellular response to drug;GO:0036002,molecular_function pre-mRNA binding;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0046872,molecular_function metal ion binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0071006,cellular_component U2-type catalytic step 1 spliceosome;GO:0071007,cellular_component U2-type catalytic step 2 spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0090316,biological_process positive regulation of intracellular protein transport	RBM22, SLT11; pre-mRNA-splicing factor RBM22/SLT11; K12872	RNA binding motif protein 22 [Source:HGNC Symbol%3BAcc:HGNC:25503]
ENSG00000138771	4.33	4.04	4.41	5.04	4.48	5.41	-0.211168276074306	4.8022243782945	0.0168315664097557	0.156736859598123	4:76435099-76783253:+	SHROOM3	17;GO:0000902,biological_process cell morphogenesis;GO:0001843,biological_process neural tube closure;GO:0002064,biological_process epithelial cell development;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005912,cellular_component adherens junction;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0008360,biological_process regulation of cell shape;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction;GO:0043296,cellular_component apical junction complex;GO:0043482,biological_process cellular pigment accumulation;GO:0045176,biological_process apical protein localization;GO:0051015,molecular_function actin filament binding	NA	shroom family member 3 [Source:HGNC Symbol%3BAcc:HGNC:30422]
ENSG00000099219	31.05	29.01	31.03	26.68	26.84	28.91	0.157257868165583	6.323200393321	0.0168446023449116	0.156740666347367	9:5765075-5833117:-	ERMP1	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	endoplasmic reticulum metallopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:23703]
ENSG00000182307	54.79	49.66	65.35	68.01	63.04	68.58	-0.217070972129279	5.4125565854197	0.0168609366816909	0.156758474378989	8:145052377-145056030:+	C8orf33	1;GO:0005515,molecular_function protein binding	NA	chromosome 8 open reading frame 33 [Source:HGNC Symbol%3BAcc:HGNC:26104]
ENSG00000170779	29.60	27.10	24.13	33.35	30.32	31.90	-0.229499981307235	4.42311730107579	0.0168777811859966	0.156758474378989	14:105009572-105021148:-	CDCA4	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0051301,biological_process cell division	NA	cell division cycle associated 4 [Source:HGNC Symbol%3BAcc:HGNC:14625]
ENSG00000145901	86.77	97.25	88.50	101.60	104.12	100.49	-0.157580128287576	7.66035274691989	0.0169125249350938	0.156758474378989	5:151029944-151093577:-	TNIP1	25;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0009101,biological_process glycoprotein biosynthetic process;GO:0016579,biological_process protein deubiquitination;GO:0031593,molecular_function polyubiquitin binding;GO:0042802,molecular_function identical protein binding;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050727,biological_process regulation of inflammatory response;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0085032,biological_process modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade;GO:1903003,biological_process positive regulation of protein deubiquitination	NA	TNFAIP3 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16903]
ENSG00000076356	0.34	0.27	0.31	0.24	0.17	0.15	0.736069996082404	0.628230699306479	0.0169142603207163	0.156758474378989	1:208022241-208244320:-	PLXNA2	19;GO:0001756,biological_process somitogenesis;GO:0002116,cellular_component semaphorin receptor complex;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0021785,biological_process branchiomotor neuron axon guidance;GO:0021915,biological_process neural tube development;GO:0021935,biological_process cerebellar granule cell precursor tangential migration;GO:0030334,biological_process regulation of cell migration;GO:0048841,biological_process regulation of axon extension involved in axon guidance;GO:0051642,biological_process centrosome localization;GO:0060037,biological_process pharyngeal system development;GO:0060174,biological_process limb bud formation;GO:0071526,biological_process semaphorin-plexin signaling pathway	PLXNA; plexin A; K06820	plexin A2 [Source:HGNC Symbol%3BAcc:HGNC:9100]
ENSG00000136738	20.09	20.58	19.98	17.88	17.36	18.74	0.177275173500439	4.95890236592245	0.0169200485004842	0.156758474378989	10:17644124-17715914:+	STAM	22;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016579,biological_process protein deubiquitination;GO:0031901,cellular_component early endosome membrane;GO:0033565,cellular_component ESCRT-0 complex;GO:0036258,biological_process multivesicular body assembly;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0061024,biological_process membrane organization;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903551,biological_process regulation of extracellular exosome assembly	STAM; signal transducing adaptor molecule; K04705	signal transducing adaptor molecule [Source:HGNC Symbol%3BAcc:HGNC:11357]
ENSG00000158828	51.50	51.26	48.56	47.25	43.86	45.75	0.156012548393114	6.39037749866013	0.0169222875749493	0.156758474378989	1:20633454-20651511:+	PINK1	111;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000422,biological_process mitophagy;GO:0000785,cellular_component chromatin;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002020,molecular_function protease binding;GO:0002082,biological_process regulation of oxidative phosphorylation;GO:0002931,biological_process response to ischemia;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006914,biological_process autophagy;GO:0006950,biological_process response to stress;GO:0006979,biological_process response to oxidative stress;GO:0007005,biological_process mitochondrion organization;GO:0010310,biological_process regulation of hydrogen peroxide metabolic process;GO:0010629,biological_process negative regulation of gene expression;GO:0010821,biological_process regulation of mitochondrion organization;GO:0010857,molecular_function calcium-dependent protein kinase activity;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016504,molecular_function peptidase activator activity;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0022904,biological_process respiratory electron transport chain;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031932,cellular_component TORC2 complex;GO:0032148,biological_process activation of protein kinase B activity;GO:0032226,biological_process positive regulation of synaptic transmission, dopaminergic;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033603,biological_process positive regulation of dopamine secretion;GO:0033605,biological_process positive regulation of catecholamine secretion;GO:0034599,biological_process cellular response to oxidative stress;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0036289,biological_process peptidyl-serine autophosphorylation;GO:0038203,biological_process TORC2 signaling;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043254,biological_process regulation of protein complex assembly;GO:0043422,molecular_function protein kinase B binding;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044297,cellular_component cell body;GO:0045727,biological_process positive regulation of translation;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0055131,molecular_function C3HC4-type RING finger domain binding;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0071456,biological_process cellular response to hypoxia;GO:0072655,biological_process establishment of protein localization to mitochondrion;GO:0072656,biological_process maintenance of protein location in mitochondrion;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0090258,biological_process negative regulation of mitochondrial fission;GO:0097237,biological_process cellular response to toxic substance;GO:0097413,cellular_component Lewy body;GO:0097449,cellular_component astrocyte projection;GO:0098779,biological_process mitophagy in response to mitochondrial depolarization;GO:0099074,biological_process mitochondrion to lysosome transport;GO:1900407,biological_process regulation of cellular response to oxidative stress;GO:1901727,biological_process positive regulation of histone deacetylase activity;GO:1902803,biological_process regulation of synaptic vesicle transport;GO:1902902,biological_process negative regulation of autophagosome assembly;GO:1902958,biological_process positive regulation of mitochondrial electron transport, NADH to ubiquinone;GO:1903146,biological_process regulation of mitophagy;GO:1903147,biological_process negative regulation of mitophagy;GO:1903202,biological_process negative regulation of oxidative stress-induced cell death;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death;GO:1903214,biological_process regulation of protein targeting to mitochondrion;GO:1903298,biological_process negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:1903384,biological_process negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway;GO:1903751,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:1903852,biological_process positive regulation of cristae formation;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1904544,biological_process positive regulation of free ubiquitin chain polymerization;GO:1904925,biological_process positive regulation of mitophagy in response to mitochondrial depolarization;GO:2000377,biological_process regulation of reactive oxygen species metabolic process;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2001171,biological_process positive regulation of ATP biosynthetic process	PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]; K05688	PTEN induced putative kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:14581]
ENSG00000082684	41.33	38.85	43.28	43.89	47.84	47.29	-0.158282160074323	7.35929373983893	0.0170010232805224	0.157370396704791	3:122909192-123028605:-	SEMA5B	12;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0038191,molecular_function neuropilin binding;GO:0048675,biological_process axon extension;GO:0050908,biological_process detection of light stimulus involved in visual perception;GO:0050919,biological_process negative chemotaxis;GO:0097485,biological_process neuron projection guidance;GO:1990138,biological_process neuron projection extension	SEMA5; semaphorin 5; K06841	semaphorin 5B [Source:HGNC Symbol%3BAcc:HGNC:10737]
ENSG00000042445	44.29	43.08	48.77	55.58	47.45	52.72	-0.181480749977529	6.62997491735215	0.0170751425145153	0.157858717024504	2:85342087-85354620:-	RETSAT	9;GO:0005640,cellular_component nuclear outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031965,cellular_component nuclear membrane;GO:0042572,biological_process retinol metabolic process;GO:0051786,molecular_function all-trans-retinol 13,14-reductase activity;GO:0055114,biological_process oxidation-reduction process	RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23]; K09516	retinol saturase [Source:HGNC Symbol%3BAcc:HGNC:25991]
ENSG00000196950	34.19	34.96	35.01	31.44	31.37	31.99	0.147228008195186	6.37231258539344	0.0170792118717401	0.157858717024504	2:195575976-195737702:+	SLC39A10	17;GO:0002903,biological_process negative regulation of B cell apoptotic process;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0050861,biological_process positive regulation of B cell receptor signaling pathway;GO:0055085,biological_process transmembrane transport;GO:0071578,biological_process zinc II ion transmembrane import;GO:1903615,biological_process positive regulation of protein tyrosine phosphatase activity	NA	solute carrier family 39 member 10 [Source:HGNC Symbol%3BAcc:HGNC:20861]
ENSG00000170085	3.88	4.63	4.88	5.63	5.71	5.04	-0.281544095769504	3.81514379338215	0.0170994248575783	0.157927946991904	5:176238366-176345991:+	SIMC1	1;GO:0032184,molecular_function SUMO polymer binding	NA	SUMO interacting motifs containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24779]
ENSG00000072134	9.78	9.25	11.02	8.35	8.88	8.59	0.235543555942206	4.20606222856218	0.0171161924103173	0.15796527612585	17:19215614-19336715:+	EPN2	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0030128,cellular_component clathrin coat of endocytic vesicle;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding;GO:0061024,biological_process membrane organization	EPN; epsin; K12471	epsin 2 [Source:HGNC Symbol%3BAcc:HGNC:18639]
ENSG00000065911	181.00	152.63	179.80	207.43	182.67	198.50	-0.184080349854452	7.59432358687673	0.0171545025914312	0.158095970763507	2:74198561-74217565:+	MTHFD2	16;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004477,molecular_function methenyltetrahydrofolate cyclohydrolase activity;GO:0004487,molecular_function methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488,molecular_function methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006730,biological_process one-carbon metabolic process;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016787,molecular_function hydrolase activity;GO:0042301,molecular_function phosphate ion binding;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046655,biological_process folic acid metabolic process;GO:0055114,biological_process oxidation-reduction process	MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]; K13403	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2%2C methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol%3BAcc:HGNC:7434]
ENSG00000146830	19.45	18.10	20.62	18.35	16.63	17.08	0.174672355501555	5.83931597424456	0.0171558263609477	0.158095970763507	7:100679506-100689448:-	GIGYF1	4;GO:0005515,molecular_function protein binding;GO:0008150,biological_process biological_process;GO:0043234,cellular_component protein complex;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway	NA	GRB10 interacting GYF protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9126]
ENSG00000163466	362.45	354.34	348.93	407.67	384.43	391.62	-0.139752460898406	8.63724103316242	0.0172619699764727	0.158900883484927	2:218217093-218254356:+	ARPC2	29;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0015629,cellular_component actin cytoskeleton;GO:0030041,biological_process actin filament polymerization;GO:0030054,cellular_component cell junction;GO:0030833,biological_process regulation of actin filament polymerization;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031252,cellular_component cell leading edge;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0036195,cellular_component muscle cell projection membrane;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	NA	actin related protein 2/3 complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:705]
ENSG00000165029	34.28	31.71	32.83	40.21	33.55	38.86	-0.176503218050509	7.98069670757683	0.0172687740128226	0.158900883484927	9:104781001-104928237:-	ABCA1	76;GO:0000166,molecular_function nucleotide binding;GO:0002790,biological_process peptide secretion;GO:0005102,molecular_function receptor binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005543,molecular_function phospholipid binding;GO:0005548,molecular_function phospholipid transporter activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006497,biological_process protein lipidation;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006911,biological_process phagocytosis, engulfment;GO:0007040,biological_process lysosome organization;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007584,biological_process response to nutrient;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0010887,biological_process negative regulation of cholesterol storage;GO:0015485,molecular_function cholesterol binding;GO:0015914,biological_process phospholipid transport;GO:0015917,biological_process aminophospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016197,biological_process endosomal transport;GO:0016887,molecular_function ATPase activity;GO:0017127,molecular_function cholesterol transporter activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019905,molecular_function syntaxin binding;GO:0030139,cellular_component endocytic vesicle;GO:0030301,biological_process cholesterol transport;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031267,molecular_function small GTPase binding;GO:0032367,biological_process intracellular cholesterol transport;GO:0032489,biological_process regulation of Cdc42 protein signal transduction;GO:0033344,biological_process cholesterol efflux;GO:0033700,biological_process phospholipid efflux;GO:0034185,molecular_function apolipoprotein binding;GO:0034186,molecular_function apolipoprotein A-I binding;GO:0034188,molecular_function apolipoprotein A-I receptor activity;GO:0034364,cellular_component high-density lipoprotein particle;GO:0034380,biological_process high-density lipoprotein particle assembly;GO:0034616,biological_process response to laminar fluid shear stress;GO:0038027,biological_process apolipoprotein A-I-mediated signaling pathway;GO:0042157,biological_process lipoprotein metabolic process;GO:0042158,biological_process lipoprotein biosynthetic process;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042632,biological_process cholesterol homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043691,biological_process reverse cholesterol transport;GO:0045121,cellular_component membrane raft;GO:0045332,biological_process phospholipid translocation;GO:0045335,cellular_component phagocytic vesicle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050702,biological_process interleukin-1 beta secretion;GO:0051117,molecular_function ATPase binding;GO:0055085,biological_process transmembrane transport;GO:0055091,biological_process phospholipid homeostasis;GO:0055098,biological_process response to low-density lipoprotein particle;GO:0060155,biological_process platelet dense granule organization;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071300,biological_process cellular response to retinoic acid;GO:0071397,biological_process cellular response to cholesterol;GO:0090107,biological_process regulation of high-density lipoprotein particle assembly;GO:0090554,molecular_function phosphatidylcholine-translocating ATPase activity;GO:0090556,molecular_function phosphatidylserine-translocating ATPase activity;GO:0098656,biological_process anion transmembrane transport	ABCA1; ATP-binding cassette, subfamily A (ABC1), member 1; K05641	ATP binding cassette subfamily A member 1 [Source:HGNC Symbol%3BAcc:HGNC:29]
ENSG00000184787	69.01	69.78	73.73	68.40	60.46	59.28	0.18853019026093	5.24829873584882	0.0173244237988488	0.159294868603785	21:44768579-44802019:-	UBE2G2	19;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035458,biological_process cellular response to interferon-beta;GO:0042802,molecular_function identical protein binding;GO:0044257,biological_process cellular protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol	UBE2G2, UBC7; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]; K04555	ubiquitin conjugating enzyme E2 G2 [Source:HGNC Symbol%3BAcc:HGNC:12483]
ENSG00000131759	14.96	14.43	16.79	18.69	17.39	17.47	-0.197621803000832	4.89395755623674	0.0174060919479057	0.159859252549708	17:40309191-40357643:+	RARA	105;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0000975,molecular_function regulatory region DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001012,molecular_function RNA polymerase II regulatory region DNA binding;GO:0001657,biological_process ureteric bud development;GO:0001843,biological_process neural tube closure;GO:0001889,biological_process liver development;GO:0001972,molecular_function retinoic acid binding;GO:0002068,biological_process glandular epithelial cell development;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003417,biological_process growth plate cartilage development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003708,molecular_function retinoic acid receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007281,biological_process germ cell development;GO:0007283,biological_process spermatogenesis;GO:0007565,biological_process female pregnancy;GO:0008134,molecular_function transcription factor binding;GO:0008144,molecular_function drug binding;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0015629,cellular_component actin cytoskeleton;GO:0017148,biological_process negative regulation of translation;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0021766,biological_process hippocampus development;GO:0030425,cellular_component dendrite;GO:0030850,biological_process prostate gland development;GO:0030852,biological_process regulation of granulocyte differentiation;GO:0030853,biological_process negative regulation of granulocyte differentiation;GO:0031076,biological_process embryonic camera-type eye development;GO:0031490,molecular_function chromatin DNA binding;GO:0031641,biological_process regulation of myelination;GO:0032355,biological_process response to estradiol;GO:0032526,biological_process response to retinoic acid;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032736,biological_process positive regulation of interleukin-13 production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0032754,biological_process positive regulation of interleukin-5 production;GO:0033189,biological_process response to vitamin A;GO:0034097,biological_process response to cytokine;GO:0035264,biological_process multicellular organism growth;GO:0042826,molecular_function histone deacetylase binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043277,biological_process apoptotic cell clearance;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043422,molecular_function protein kinase B binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044323,molecular_function retinoic acid-responsive element binding;GO:0045471,biological_process response to ethanol;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045630,biological_process positive regulation of T-helper 2 cell differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045787,biological_process positive regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045947,biological_process negative regulation of translational initiation;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051018,molecular_function protein kinase A binding;GO:0051099,biological_process positive regulation of binding;GO:0051393,molecular_function alpha-actinin binding;GO:0055012,biological_process ventricular cardiac muscle cell differentiation;GO:0060010,biological_process Sertoli cell fate commitment;GO:0060173,biological_process limb development;GO:0060324,biological_process face development;GO:0060348,biological_process bone development;GO:0060534,biological_process trachea cartilage development;GO:0060591,biological_process chondroblast differentiation;GO:0061037,biological_process negative regulation of cartilage development;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071300,biological_process cellular response to retinoic acid;GO:0071391,biological_process cellular response to estrogen stimulus	RARA, NR1B1; retinoic acid receptor alpha; K08527	retinoic acid receptor alpha [Source:HGNC Symbol%3BAcc:HGNC:9864]
ENSG00000137124	25.96	29.33	23.44	22.01	24.30	22.12	0.208830752627299	5.25148605821539	0.0174115612218807	0.159859252549708	9:38392663-38398661:+	ALDH1B1	12;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006068,biological_process ethanol catabolic process;GO:0006069,biological_process ethanol oxidation;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process	ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]; K00128	aldehyde dehydrogenase 1 family member B1 [Source:HGNC Symbol%3BAcc:HGNC:407]
ENSG00000176788	95.83	86.72	95.22	85.21	78.52	86.22	0.166594973080449	5.90971490958821	0.017474669191143	0.16032008031756	5:17065597-17276843:+	BASP1	26;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007356,biological_process thorax and anterior abdomen determination;GO:0008180,cellular_component COP9 signalosome;GO:0008406,biological_process gonad development;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0019904,molecular_function protein domain specific binding;GO:0021762,biological_process substantia nigra development;GO:0030054,cellular_component cell junction;GO:0030426,cellular_component growth cone;GO:0031982,cellular_component vesicle;GO:0042995,cellular_component cell projection;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0060231,biological_process mesenchymal to epithelial transition;GO:0060421,biological_process positive regulation of heart growth;GO:0060539,biological_process diaphragm development;GO:0070062,cellular_component extracellular exosome;GO:0072075,biological_process metanephric mesenchyme development;GO:0072112,biological_process glomerular visceral epithelial cell differentiation;GO:2001076,biological_process positive regulation of metanephric ureteric bud development	NA	brain abundant membrane attached signal protein 1 [Source:HGNC Symbol%3BAcc:HGNC:957]
ENSG00000204764	1.86	1.90	1.49	2.28	2.29	2.17	-0.355113070354924	2.76039782048617	0.0175167779207196	0.160587713685298	5:170861869-171300015:+	RANBP17	13;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0006606,biological_process protein import into nucleus;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0051028,biological_process mRNA transport	NA	RAN binding protein 17 [Source:HGNC Symbol%3BAcc:HGNC:14428]
ENSG00000169122	16.73	19.37	19.56	15.45	16.60	15.65	0.230577360971096	4.26490620452384	0.0175718206553588	0.160842549415424	8:57994508-58204279:+	FAM110B	5;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton	NA	family with sequence similarity 110 member B [Source:HGNC Symbol%3BAcc:HGNC:28587]
ENSG00000157224	48.62	56.69	49.17	46.55	45.09	44.30	0.190149668291707	5.15553901198622	0.0175813716071956	0.160842549415424	7:90383720-90513402:+	CLDN12	11;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016338,biological_process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030054,cellular_component cell junction;GO:0042802,molecular_function identical protein binding;GO:0071944,cellular_component cell periphery	NA	claudin 12 [Source:HGNC Symbol%3BAcc:HGNC:2034]
ENSG00000122203	71.24	74.36	74.00	82.24	85.54	78.77	-0.155726348432353	6.15562495914128	0.0175834479623565	0.160842549415424	5:176346060-176361968:-	KIAA1191	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	KIAA1191 [Source:HGNC Symbol%3BAcc:HGNC:29209]
ENSG00000162231	38.36	42.86	37.85	33.80	38.67	32.88	0.186500745911471	6.25379180659039	0.0176100709299653	0.160967459833328	11:62792122-62806302:-	NXF1	21;GO:0000346,cellular_component transcription export complex;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0016032,biological_process viral process;GO:0016607,cellular_component nuclear speck;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0042405,cellular_component nuclear inclusion body;GO:0051028,biological_process mRNA transport	NXF, TAP, MEX67; nuclear RNA export factor; K14284	nuclear RNA export factor 1 [Source:HGNC Symbol%3BAcc:HGNC:8071]
ENSG00000196923	46.36	42.03	43.46	50.50	47.24	50.76	-0.158244360066255	6.41394162651898	0.0176332243858302	0.160999825684081	5:177483393-177497606:-	PDLIM7	18;GO:0001503,biological_process ossification;GO:0001725,cellular_component stress fiber;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0015629,cellular_component actin cytoskeleton;GO:0030036,biological_process actin cytoskeleton organization;GO:0030154,biological_process cell differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0046872,molecular_function metal ion binding	NA	PDZ and LIM domain 7 [Source:HGNC Symbol%3BAcc:HGNC:22958]
ENSG00000153132	3.70	3.29	5.39	2.82	3.52	2.73	0.470860879048084	2.74689873381696	0.0176395523185652	0.160999825684081	4:140388454-140427968:-	CLGN	12;GO:0005509,molecular_function calcium ion binding;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0006461,biological_process protein complex assembly;GO:0007338,biological_process single fertilization;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0044183,molecular_function protein binding involved in protein folding;GO:0051082,molecular_function unfolded protein binding	NA	calmegin [Source:HGNC Symbol%3BAcc:HGNC:2060]
ENSG00000204991	4.29	3.38	3.76	3.20	3.28	2.46	0.378698779903001	2.91424037097061	0.0176572265682779	0.161023808267989	16:89818178-89871319:+	SPIRE2	21;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030036,biological_process actin cytoskeleton organization;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032154,cellular_component cleavage furrow;GO:0036089,biological_process cleavage furrow formation;GO:0040038,biological_process polar body extrusion after meiotic divisions;GO:0045010,biological_process actin nucleation;GO:0046907,biological_process intracellular transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051295,biological_process establishment of meiotic spindle localization;GO:0070649,biological_process formin-nucleated actin cable assembly	SPIR; spire; K02098	spire type actin nucleation factor 2 [Source:HGNC Symbol%3BAcc:HGNC:30623]
ENSG00000164932	307.14	321.61	308.86	257.59	307.30	275.37	0.169736888686902	8.07015367857257	0.0176681242939661	0.161023808267989	8:103371514-103382997:+	CTHRC1	17;GO:0005109,molecular_function frizzled binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0016477,biological_process cell migration;GO:0017147,molecular_function Wnt-protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0033690,biological_process positive regulation of osteoblast proliferation;GO:0043932,biological_process ossification involved in bone remodeling;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090103,biological_process cochlea morphogenesis;GO:0090177,biological_process establishment of planar polarity involved in neural tube closure	NA	collagen triple helix repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18831]
ENSG00000078018	1.74	1.61	1.41	1.22	1.33	1.32	0.315774863841092	3.14130618071815	0.0177367656201446	0.161512493519948	2:209424057-209734118:+	MAP2	32;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001578,biological_process microtubule bundle formation;GO:0002162,molecular_function dystroglycan binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005622,cellular_component intracellular;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0007409,biological_process axonogenesis;GO:0008017,molecular_function microtubule binding;GO:0014069,cellular_component postsynaptic density;GO:0015631,molecular_function tubulin binding;GO:0016358,biological_process dendrite development;GO:0021954,biological_process central nervous system neuron development;GO:0030010,biological_process establishment of cell polarity;GO:0030425,cellular_component dendrite;GO:0031175,biological_process neuron projection development;GO:0034399,cellular_component nuclear periphery;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043198,cellular_component dendritic shaft;GO:0044297,cellular_component cell body;GO:0048813,biological_process dendrite morphogenesis;GO:0050770,biological_process regulation of axonogenesis;GO:0071310,biological_process cellular response to organic substance;GO:0097442,cellular_component CA3 pyramidal cell dendrite	NA	microtubule associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6839]
ENSG00000122643	49.05	38.51	47.77	54.50	46.48	60.79	-0.242055496220992	5.74643122775338	0.0177477677564819	0.161512493519948	7:33014113-33062797:-	NT5C3A	17;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006213,biological_process pyrimidine nucleoside metabolic process;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0008665,molecular_function 2'-phosphotransferase activity;GO:0009117,biological_process nucleotide metabolic process;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0046085,biological_process adenosine metabolic process;GO:0046135,biological_process pyrimidine nucleoside catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus	E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]; K01081	5'-nucleotidase%2C cytosolic IIIA [Source:HGNC Symbol%3BAcc:HGNC:17820]
ENSG00000141696	16.43	18.59	15.61	14.68	14.87	13.95	0.223991940853176	4.36740813022037	0.0177942685947037	0.161817037411031	17:41801946-41812604:-	P3H4	6;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000795,cellular_component synaptonemal complex;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0007130,biological_process synaptonemal complex assembly	NA	prolyl 3-hydroxylase family member 4 (non-enzymatic) [Source:HGNC Symbol%3BAcc:HGNC:16946]
ENSG00000100320	43.73	44.39	47.67	48.84	52.39	51.51	-0.157438528634131	6.18394224665512	0.0178320855166378	0.162042223658877	22:35738735-36028425:-	RBFOX2	24;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010724,biological_process regulation of definitive erythrocyte differentiation;GO:0016070,biological_process RNA metabolic process;GO:0021942,biological_process radial glia guided migration of Purkinje cell;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0043484,biological_process regulation of RNA splicing;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048813,biological_process dendrite morphogenesis;GO:0050885,biological_process neuromuscular process controlling balance	NA	RNA binding protein%2C fox-1 homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:9906]
ENSG00000188163	1.44	0.46	1.28	0.22	0.59	0.75	1.07276925078526	-0.0184009888367886	0.0178617726100264	0.162193257796824	9:137243583-137247770:-	FAM166A	1;GO:0005634,cellular_component nucleus	NA	family with sequence similarity 166 member A [Source:HGNC Symbol%3BAcc:HGNC:33818]
ENSG00000196562	0.35	0.37	0.28	0.43	0.73	0.59	-0.797280903073679	0.438327717813098	0.0178981573847212	0.162404844748936	20:47656347-47786616:-	SULF2	33;GO:0001822,biological_process kidney development;GO:0002063,biological_process chondrocyte development;GO:0003094,biological_process glomerular filtration;GO:0003824,molecular_function catalytic activity;GO:0004065,molecular_function arylsulfatase activity;GO:0005509,molecular_function calcium ion binding;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005886,cellular_component plasma membrane;GO:0008152,biological_process metabolic process;GO:0008449,molecular_function N-acetylglucosamine-6-sulfatase activity;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0009611,biological_process response to wounding;GO:0009986,cellular_component cell surface;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0014846,biological_process esophagus smooth muscle contraction;GO:0016787,molecular_function hydrolase activity;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030201,biological_process heparan sulfate proteoglycan metabolic process;GO:0032836,biological_process glomerular basement membrane development;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0035860,biological_process glial cell-derived neurotrophic factor receptor signaling pathway;GO:0040037,biological_process negative regulation of fibroblast growth factor receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0048706,biological_process embryonic skeletal system development;GO:0051216,biological_process cartilage development;GO:0060348,biological_process bone development;GO:0060384,biological_process innervation;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097421,biological_process liver regeneration;GO:2000345,biological_process regulation of hepatocyte proliferation	NA	sulfatase 2 [Source:HGNC Symbol%3BAcc:HGNC:20392]
ENSG00000196975	1205.88	1345.11	1239.39	1017.59	1255.53	1072.15	0.191994923644367	10.192569679753	0.0180414005494552	0.1635850292333	2:69644424-69827100:+	ANXA4	24;GO:0004859,molecular_function phospholipase inhibitor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007219,biological_process Notch signaling pathway;GO:0009986,cellular_component cell surface;GO:0012506,cellular_component vesicle membrane;GO:0030855,biological_process epithelial cell differentiation;GO:0031965,cellular_component nuclear membrane;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050819,biological_process negative regulation of coagulation;GO:0051059,molecular_function NF-kappaB binding;GO:0070062,cellular_component extracellular exosome;GO:2000483,biological_process negative regulation of interleukin-8 secretion	NA	annexin A4 [Source:HGNC Symbol%3BAcc:HGNC:542]
ENSG00000148700	31.88	33.75	32.60	34.57	38.74	37.28	-0.160903513054843	6.20774462373086	0.0181421173034129	0.164378176706033	10:109996367-110135565:+	ADD3	17;GO:0000794,cellular_component condensed nuclear chromosome;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005516,molecular_function calmodulin binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005911,cellular_component cell-cell junction;GO:0005938,cellular_component cell cortex;GO:0007010,biological_process cytoskeleton organization;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0055085,biological_process transmembrane transport	NA	adducin 3 [Source:HGNC Symbol%3BAcc:HGNC:245]
ENSG00000039523	35.85	36.50	34.98	39.57	43.58	37.98	-0.162978338199461	7.16964917766673	0.018287636857864	0.165467559013454	16:67518417-67546788:+	RIPOR1	16;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0007266,biological_process Rho protein signal transduction;GO:0008150,biological_process biological_process;GO:0009267,biological_process cellular response to starvation;GO:0009611,biological_process response to wounding;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0051683,biological_process establishment of Golgi localization;GO:0070062,cellular_component extracellular exosome;GO:0071889,molecular_function 14-3-3 protein binding;GO:0090316,biological_process positive regulation of intracellular protein transport	NA	RHO family interacting cell polarization regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:25836]
ENSG00000139343	43.95	49.53	44.72	51.78	54.25	53.00	-0.197005420450397	4.77074981127203	0.018289010792432	0.165467559013454	12:95858927-95903828:+	SNRPF	25;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005683,cellular_component U7 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0034709,cellular_component methylosome;GO:0034715,cellular_component pICln-Sm protein complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	small nuclear ribonucleoprotein polypeptide F [Source:HGNC Symbol%3BAcc:HGNC:11162]
ENSG00000123066	8.65	6.73	8.81	9.56	8.76	10.11	-0.216788636827064	5.89835498601771	0.0183160364337352	0.165591376731213	12:115953871-116277338:-	MED13L	6;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016592,cellular_component mediator complex	MED13; mediator of RNA polymerase II transcription subunit 13; K15164	mediator complex subunit 13 like [Source:HGNC Symbol%3BAcc:HGNC:22962]
ENSG00000176974	95.54	106.23	91.18	79.81	96.53	80.71	0.199503741787315	7.29525595270554	0.0183617808468928	0.165826048829038	17:18327859-18363563:-	SHMT1	36;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003824,molecular_function catalytic activity;GO:0004372,molecular_function glycine hydroxymethyltransferase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006231,biological_process dTMP biosynthetic process;GO:0006544,biological_process glycine metabolic process;GO:0006545,biological_process glycine biosynthetic process;GO:0006563,biological_process L-serine metabolic process;GO:0006565,biological_process L-serine catabolic process;GO:0006730,biological_process one-carbon metabolic process;GO:0008732,molecular_function L-allo-threonine aldolase activity;GO:0009113,biological_process purine nucleobase biosynthetic process;GO:0016579,biological_process protein deubiquitination;GO:0016597,molecular_function amino acid binding;GO:0016740,molecular_function transferase activity;GO:0017148,biological_process negative regulation of translation;GO:0019264,biological_process glycine biosynthetic process from serine;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045329,biological_process carnitine biosynthetic process;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046655,biological_process folic acid metabolic process;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0051262,biological_process protein tetramerization;GO:0051289,biological_process protein homotetramerization;GO:0070062,cellular_component extracellular exosome;GO:0070905,molecular_function serine binding;GO:1904482,biological_process cellular response to tetrahydrofolate;GO:1990830,biological_process cellular response to leukemia inhibitory factor	glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]; K00600	serine hydroxymethyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:10850]
ENSG00000223658	1.35	1.62	1.79	2.30	2.49	2.60	-0.62787082478991	1.05420312372321	0.0183687116039577	0.165826048829038	2:43675150-43676322:-	C1GALT1C1L	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	C1GALT1-specific chaperone 1 like [Source:HGNC Symbol%3BAcc:HGNC:51617]
ENSG00000077063	6.81	6.68	6.71	5.51	6.56	5.72	0.196107092138586	5.00598040729076	0.0184649388349801	0.166494701857267	7:117710650-117874139:-	CTTNBP2	7;GO:0005737,cellular_component cytoplasm;GO:0005938,cellular_component cell cortex;GO:0007420,biological_process brain development;GO:0008021,cellular_component synaptic vesicle;GO:0017124,molecular_function SH3 domain binding;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine	NA	cortactin binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15679]
ENSG00000005436	10.17	10.30	11.89	8.77	10.15	9.07	0.223673950755645	4.63672853849163	0.0184696048060466	0.166494701857267	2:75651999-75710989:-	GCFC2	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000245,biological_process spliceosomal complex assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0071008,cellular_component U2-type post-mRNA release spliceosomal complex	NA	GC-rich sequence DNA-binding factor 2 [Source:HGNC Symbol%3BAcc:HGNC:1317]
ENSG00000038002	19.80	20.62	21.06	15.36	20.02	16.80	0.248402921261175	4.30629018376965	0.0185318633777899	0.166932951458143	4:177430769-177442503:-	AGA	14;GO:0003948,molecular_function N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0006508,biological_process proteolysis;GO:0006517,biological_process protein deglycosylation;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043621,molecular_function protein self-association;GO:0051604,biological_process protein maturation;GO:0070062,cellular_component extracellular exosome	AGA, aspG; N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26]; K01444	aspartylglucosaminidase [Source:HGNC Symbol%3BAcc:HGNC:318]
ENSG00000113013	216.36	175.14	225.54	260.14	209.48	263.89	-0.237320153170563	8.98768203208735	0.0185451172207185	0.166932951458143	5:138554881-138575444:-	HSPA9	20;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005925,cellular_component focal adhesion;GO:0006457,biological_process protein folding;GO:0030218,biological_process erythrocyte differentiation;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045647,biological_process negative regulation of erythrocyte differentiation;GO:0051082,molecular_function unfolded protein binding;GO:0070062,cellular_component extracellular exosome	dnaK, HSPA9; molecular chaperone DnaK; K04043	heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol%3BAcc:HGNC:5244]
ENSG00000110881	0.74	0.50	1.01	1.09	1.10	1.28	-0.57930847699916	1.35337194412564	0.018608572254804	0.167382758984698	12:50057547-50083611:+	ASIC1	32;GO:0005216,molecular_function ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0006816,biological_process calcium ion transport;GO:0007165,biological_process signal transduction;GO:0007613,biological_process memory;GO:0008306,biological_process associative learning;GO:0009268,biological_process response to pH;GO:0009986,cellular_component cell surface;GO:0010447,biological_process response to acidic pH;GO:0015280,molecular_function ligand-gated sodium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022839,molecular_function ion gated channel activity;GO:0034220,biological_process ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0044736,molecular_function acid-sensing ion channel activity;GO:0045202,cellular_component synapse;GO:0046929,biological_process negative regulation of neurotransmitter secretion;GO:0050915,biological_process sensory perception of sour taste;GO:0070207,biological_process protein homotrimerization;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071467,biological_process cellular response to pH	ASIC1, ACCN2, BNAC2; acid-sensing ion channel 1; K04829	acid sensing ion channel subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:100]
ENSG00000164535	22.25	23.42	23.04	25.37	24.87	27.17	-0.162746287549102	5.62323058467423	0.0186840912204899	0.167922501022667	7:6409125-6484190:-	DAGLB	14;GO:0005634,cellular_component nucleus;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007405,biological_process neuroblast proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0022008,biological_process neurogenesis;GO:0042136,biological_process neurotransmitter biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0047372,molecular_function acylglycerol lipase activity	DAGL; sn1-specific diacylglycerol lipase [EC:3.1.1.-]; K13806	diacylglycerol lipase beta [Source:HGNC Symbol%3BAcc:HGNC:28923]
ENSG00000148719	28.84	27.74	27.88	25.67	25.76	24.11	0.174447307035404	5.07007213718179	0.0186986892516939	0.167922501022667	10:72332829-72355230:-	DNAJB12	13;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030544,molecular_function Hsp70 protein binding;GO:0031965,cellular_component nuclear membrane;GO:0036503,biological_process ERAD pathway;GO:0043623,biological_process cellular protein complex assembly;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0070389,biological_process chaperone cofactor-dependent protein refolding;GO:0071218,biological_process cellular response to misfolded protein	DNAJB12; DnaJ homolog subfamily B member 12; K09518	DnaJ heat shock protein family (Hsp40) member B12 [Source:HGNC Symbol%3BAcc:HGNC:14891]
ENSG00000120049	3.51	4.28	3.87	3.50	2.29	2.46	0.499846224272315	1.81812980311666	0.0187091612756263	0.167922501022667	10:101825973-101843920:-	KCNIP2	34;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005250,molecular_function A-type (transient outward) potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005513,biological_process detection of calcium ion;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006936,biological_process muscle contraction;GO:0007165,biological_process signal transduction;GO:0007268,biological_process chemical synaptic transmission;GO:0008016,biological_process regulation of heart contraction;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0034705,cellular_component potassium channel complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0044325,molecular_function ion channel binding;GO:0045163,biological_process clustering of voltage-gated potassium channels;GO:0046872,molecular_function metal ion binding;GO:0046923,molecular_function ER retention sequence binding;GO:0047485,molecular_function protein N-terminus binding;GO:0061337,biological_process cardiac conduction;GO:0071435,biological_process potassium ion export;GO:0071805,biological_process potassium ion transmembrane transport;GO:0086008,molecular_function voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0086009,biological_process membrane repolarization;GO:0086013,biological_process membrane repolarization during cardiac muscle cell action potential;GO:0097623,biological_process potassium ion export across plasma membrane;GO:1901379,biological_process regulation of potassium ion transmembrane transport;GO:2001257,biological_process regulation of cation channel activity	NA	potassium voltage-gated channel interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15522]
ENSG00000145919	65.15	68.87	68.40	78.74	69.83	83.53	-0.188099945792337	5.39950104716675	0.0187767754650427	0.168407596710676	5:173607513-173616660:-	BOD1	9;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0051301,biological_process cell division	NA	biorientation of chromosomes in cell division 1 [Source:HGNC Symbol%3BAcc:HGNC:25114]
ENSG00000187601	8.17	10.47	6.95	6.84	6.00	5.99	0.435635707443091	2.30801825081662	0.0188014900110552	0.168507505781392	X:55452104-55453566:+	MAGEH1	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process	NA	MAGE family member H1 [Source:HGNC Symbol%3BAcc:HGNC:24092]
ENSG00000185640	2.55	2.12	1.63	4.15	2.10	3.32	-0.590680758244581	2.30995099258667	0.0188500098931592	0.168785644467268	12:52821409-52834295:-	KRT79	9;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0019899,molecular_function enzyme binding;GO:0031424,biological_process keratinization;GO:0045095,cellular_component keratin filament;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification	NA	keratin 79 [Source:HGNC Symbol%3BAcc:HGNC:28930]
ENSG00000166881	10.34	10.12	9.84	12.03	13.04	11.14	-0.243677621815544	3.90106823381828	0.0188597187526062	0.168785644467268	12:57055642-57088063:-	NEMP1	7;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear envelope integral membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29001]
ENSG00000140264	469.84	397.33	468.71	398.25	403.12	397.92	0.168100265154092	8.35548641868637	0.0189145602445192	0.169154493022491	15:43777086-43802589:+	SERF2	4;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process	NA	small EDRK-rich factor 2 [Source:HGNC Symbol%3BAcc:HGNC:10757]
ENSG00000213654	4.02	4.00	4.56	6.02	5.59	6.24	-0.488624338764357	1.67915243386024	0.0189653629941256	0.169486717671764	6:32190765-32195523:-	GPSM3	14;GO:0002690,biological_process positive regulation of leukocyte chemotaxis;GO:0003674,molecular_function molecular_function;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0008150,biological_process biological_process;GO:0030695,molecular_function GTPase regulator activity;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050790,biological_process regulation of catalytic activity;GO:1900015,biological_process regulation of cytokine production involved in inflammatory response;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response	NA	G protein signaling modulator 3 [Source:HGNC Symbol%3BAcc:HGNC:13945]
ENSG00000173214	8.09	8.79	7.72	7.32	6.69	6.56	0.264072687477141	3.56129406318699	0.0190874117278889	0.170374151776063	6:111259347-111271167:+	MFSD4B	12;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0008643,biological_process carbohydrate transport;GO:0015293,molecular_function symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0055085,biological_process transmembrane transport;GO:1904659,biological_process glucose transmembrane transport	NA	major facilitator superfamily domain containing 4B [Source:HGNC Symbol%3BAcc:HGNC:21053]
ENSG00000166900	66.64	82.60	71.79	53.67	75.36	55.52	0.27068881703959	6.21400146879875	0.0190921167421657	0.170374151776063	11:59713455-59805882:+	STX3	46;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005773,cellular_component vacuole;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0008021,cellular_component synaptic vesicle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016081,biological_process synaptic vesicle docking;GO:0016192,biological_process vesicle-mediated transport;GO:0016324,cellular_component apical plasma membrane;GO:0030027,cellular_component lamellipodium;GO:0030141,cellular_component secretory granule;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0031175,biological_process neuron projection development;GO:0031201,cellular_component SNARE complex;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0042470,cellular_component melanosome;GO:0042581,cellular_component specific granule;GO:0042582,cellular_component azurophil granule;GO:0042589,cellular_component zymogen granule membrane;GO:0042734,cellular_component presynaptic membrane;GO:0043005,cellular_component neuron projection;GO:0045785,biological_process positive regulation of cell adhesion;GO:0048278,biological_process vesicle docking;GO:0050544,molecular_function arachidonic acid binding;GO:0050921,biological_process positive regulation of chemotaxis;GO:0060291,biological_process long-term synaptic potentiation;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome;GO:0097470,cellular_component ribbon synapse;GO:0098793,cellular_component presynapse;GO:0098794,cellular_component postsynapse;GO:0098967,biological_process exocytic insertion of neurotransmitter receptor to postsynaptic membrane;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:1990796,cellular_component photoreceptor cell terminal bouton;GO:2000010,biological_process positive regulation of protein localization to cell surface	STX1B_2_3; syntaxin 1B/2/3; K08486	syntaxin 3 [Source:HGNC Symbol%3BAcc:HGNC:11438]
ENSG00000139178	33.14	32.61	33.95	28.97	31.80	29.22	0.160950600925485	5.70176750879057	0.0191348340743607	0.170632683451896	12:7089586-7109273:-	C1RL	11;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006958,biological_process complement activation, classical pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome	NA	complement C1r subcomponent like [Source:HGNC Symbol%3BAcc:HGNC:21265]
ENSG00000135297	11.56	9.62	11.37	14.27	11.09	13.57	-0.241584745191771	4.85989160179961	0.0191924686526069	0.171023771274091	6:73461577-73509236:+	MTO1	9;GO:0002098,biological_process tRNA wobble uridine modification;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0008033,biological_process tRNA processing;GO:0016491,molecular_function oxidoreductase activity;GO:0030488,biological_process tRNA methylation;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0070899,biological_process mitochondrial tRNA wobble uridine modification	NA	mitochondrial tRNA translation optimization 1 [Source:HGNC Symbol%3BAcc:HGNC:19261]
ENSG00000188706	35.18	34.48	37.95	31.75	33.06	31.55	0.17366521603442	5.2207461573582	0.0192373229028586	0.171300494399701	X:129803287-129843909:-	ZDHHC9	17;GO:0000139,cellular_component Golgi membrane;GO:0002178,cellular_component palmitoyltransferase complex;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018230,biological_process peptidyl-L-cysteine S-palmitoylation;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0031228,cellular_component intrinsic component of Golgi membrane;GO:0043849,molecular_function Ras palmitoyltransferase activity	NA	zinc finger DHHC-type containing 9 [Source:HGNC Symbol%3BAcc:HGNC:18475]
ENSG00000166432	13.54	11.88	14.27	14.55	15.49	16.20	-0.202450986433183	4.79038551339202	0.0192751584495469	0.171413892314367	X:101882287-101932031:-	ZMAT1	8;GO:0002039,molecular_function p53 binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	NA	zinc finger matrin-type 1 [Source:HGNC Symbol%3BAcc:HGNC:29377]
ENSG00000198205	2.03	1.36	1.57	1.06	1.23	1.26	0.50515302999918	1.8359609652345	0.0192776761194599	0.171413892314367	X:57906707-57910820:-	ZXDA	9;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070742,molecular_function C2H2 zinc finger domain binding	NA	zinc finger%2C X-linked%2C duplicated A [Source:HGNC Symbol%3BAcc:HGNC:13198]
ENSG00000196453	8.10	7.71	9.42	10.60	9.70	9.51	-0.223688532696515	4.52952111829179	0.0193459229144439	0.17183246641792	7:149431362-149461123:-	ZNF777	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 777 [Source:HGNC Symbol%3BAcc:HGNC:22213]
ENSG00000117280	31.66	34.52	32.51	38.11	40.72	36.14	-0.211802697500469	4.44924149525751	0.0193524359987314	0.17183246641792	1:205767985-205775460:-	RAB29	47;GO:0000166,molecular_function nucleotide binding;GO:0001921,biological_process positive regulation of receptor recycling;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005769,cellular_component early endosome;GO:0005773,cellular_component vacuole;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007005,biological_process mitochondrion organization;GO:0007030,biological_process Golgi organization;GO:0007416,biological_process synapse assembly;GO:0009617,biological_process response to bacterium;GO:0010977,biological_process negative regulation of neuron projection development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017137,molecular_function Rab GTPase binding;GO:0019003,molecular_function GDP binding;GO:0019894,molecular_function kinesin binding;GO:0020003,cellular_component symbiont-containing vacuole;GO:0030154,biological_process cell differentiation;GO:0031982,cellular_component vesicle;GO:0032438,biological_process melanosome organization;GO:0039694,biological_process viral RNA genome replication;GO:0042110,biological_process T cell activation;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042470,cellular_component melanosome;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050862,biological_process positive regulation of T cell receptor signaling pathway;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:0070840,molecular_function dynein complex binding;GO:0072657,biological_process protein localization to membrane;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0097708,cellular_component intracellular vesicle;GO:1901214,biological_process regulation of neuron death;GO:1903441,biological_process protein localization to ciliary membrane;GO:1905279,biological_process regulation of retrograde transport, endosome to Golgi;GO:1990967,biological_process multi-organism toxin transport	NA	RAB29%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9789]
ENSG00000100461	10.13	9.57	9.94	12.38	13.35	10.40	-0.269330700311684	3.87120149255306	0.0195044711165326	0.173058613273423	14:22893205-22919184:-	RBM23	6;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0016020,cellular_component membrane	NA	RNA binding motif protein 23 [Source:HGNC Symbol%3BAcc:HGNC:20155]
ENSG00000186010	22.01	20.97	24.47	19.84	18.71	19.36	0.236639014764555	4.02268996163723	0.0195216496874016	0.173087312549797	19:19515735-19529054:+	NDUFA13	32;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006915,biological_process apoptotic process;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035458,biological_process cellular response to interferon-beta;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045039,biological_process protein import into mitochondrial inner membrane;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain;GO:0071300,biological_process cellular response to retinoic acid;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13; K11353	NADH:ubiquinone oxidoreductase subunit A13 [Source:HGNC Symbol%3BAcc:HGNC:17194]
ENSG00000105708	6.49	5.21	5.31	4.74	3.82	5.07	0.334646723747058	3.32378804159622	0.019553439644466	0.173245429198256	19:19710470-19733097:-	ZNF14	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 14 [Source:HGNC Symbol%3BAcc:HGNC:12924]
ENSG00000114054	35.11	36.30	33.31	40.81	39.91	37.14	-0.160031239401648	6.26210234550781	0.0196013449004162	0.173315636938449	3:136250305-136337896:+	PCCB	14;GO:0000166,molecular_function nucleotide binding;GO:0003989,molecular_function acetyl-CoA carboxylase activity;GO:0004658,molecular_function propionyl-CoA carboxylase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006768,biological_process biotin metabolic process;GO:0009062,biological_process fatty acid catabolic process;GO:0009317,cellular_component acetyl-CoA carboxylase complex;GO:0016421,molecular_function CoA carboxylase activity;GO:0016874,molecular_function ligase activity;GO:0019626,biological_process short-chain fatty acid catabolic process	PCCB, pccB; propionyl-CoA carboxylase beta chain [EC:6.4.1.3 2.1.3.15]; K01966	propionyl-CoA carboxylase beta subunit [Source:HGNC Symbol%3BAcc:HGNC:8654]
ENSG00000179271	50.05	47.64	43.65	52.05	53.07	56.80	-0.185214309152904	5.08187088045826	0.0196149341965116	0.173315636938449	19:12953118-12957236:-	GADD45GIP1	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005761,cellular_component mitochondrial ribosome;GO:0005840,cellular_component ribosome;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016032,biological_process viral process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination;GO:0071850,biological_process mitotic cell cycle arrest;GO:1903862,biological_process positive regulation of oxidative phosphorylation	NA	GADD45G interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29996]
ENSG00000090615	8.90	9.42	9.07	8.19	8.68	7.55	0.176845340080105	5.33349867860629	0.0196167173846545	0.173315636938449	12:132768908-132828858:-	GOLGA3	16;GO:0000139,cellular_component Golgi membrane;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032580,cellular_component Golgi cisterna membrane;GO:0045296,molecular_function cadherin binding;GO:0090498,cellular_component extrinsic component of Golgi membrane	NA	golgin A3 [Source:HGNC Symbol%3BAcc:HGNC:4426]
ENSG00000140853	8.51	7.80	9.00	7.82	7.76	6.92	0.185835443770728	5.57743098958833	0.0196286178726833	0.173315636938449	16:56989484-57083531:+	NLRC5	19;GO:0000166,molecular_function nucleotide binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0043549,biological_process regulation of kinase activity;GO:0045087,biological_process innate immune response;GO:0045345,biological_process positive regulation of MHC class I biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051607,biological_process defense response to virus;GO:0060335,biological_process positive regulation of interferon-gamma-mediated signaling pathway;GO:0060339,biological_process negative regulation of type I interferon-mediated signaling pathway;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway	NA	NLR family CARD domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:29933]
ENSG00000239697	7.01	6.28	7.87	5.40	4.50	6.16	0.413952874318002	2.31521014398396	0.0196311758265898	0.173315636938449	17:7548890-7557890:+	TNFSF12	24;GO:0001525,biological_process angiogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0043542,biological_process endothelial cell migration;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	TNFSF12, TWEAK; tumor necrosis factor ligand superfamily member 12; K05474	TNF superfamily member 12 [Source:HGNC Symbol%3BAcc:HGNC:11927]
ENSG00000132541	58.13	67.45	53.99	70.56	75.39	64.59	-0.223465005905923	5.03656052359146	0.0196524748147866	0.173380362385179	8:98102343-98117241:-	RIDA	27;GO:0001822,biological_process kidney development;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0007420,biological_process brain development;GO:0016787,molecular_function hydrolase activity;GO:0016892,molecular_function endoribonuclease activity, producing 3'-phosphomonoesters;GO:0017148,biological_process negative regulation of translation;GO:0019239,molecular_function deaminase activity;GO:0030324,biological_process lung development;GO:0033993,biological_process response to lipid;GO:0036041,molecular_function long-chain fatty acid binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043167,molecular_function ion binding;GO:0046914,molecular_function transition metal ion binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070314,biological_process G1 to G0 transition;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:1901565,biological_process organonitrogen compound catabolic process;GO:1902074,biological_process response to salt;GO:1904012,molecular_function platinum binding;GO:1904013,molecular_function xenon atom binding	NA	reactive intermediate imine deaminase A homolog [Source:HGNC Symbol%3BAcc:HGNC:16897]
ENSG00000008300	0.43	0.44	0.68	0.44	0.31	0.34	0.526538011705887	2.17746204083717	0.0197261973720559	0.173907164758046	3:48636468-48662915:-	CELSR3	23;GO:0001764,biological_process neuron migration;GO:0001932,biological_process regulation of protein phosphorylation;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007413,biological_process axonal fasciculation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032880,biological_process regulation of protein localization;GO:0036514,biological_process dopaminergic neuron axon guidance;GO:0036515,biological_process serotonergic neuron axon guidance;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060271,biological_process cilium morphogenesis;GO:1904938,biological_process planar cell polarity pathway involved in axon guidance	NA	cadherin EGF LAG seven-pass G-type receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:3230]
ENSG00000151012	22.56	18.06	24.58	26.95	25.48	24.70	-0.223219928916589	5.16829974349316	0.0198562106852287	0.174929129336937	4:138164096-138242349:-	SLC7A11	22;GO:0003333,biological_process amino acid transmembrane transport;GO:0005515,molecular_function protein binding;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0006979,biological_process response to oxidative stress;GO:0007420,biological_process brain development;GO:0009636,biological_process response to toxic substance;GO:0009986,cellular_component cell surface;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015327,molecular_function cystine:glutamate antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035094,biological_process response to nicotine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050900,biological_process leukocyte migration;GO:0070306,biological_process lens fiber cell differentiation;GO:0070527,biological_process platelet aggregation;GO:0089711,biological_process L-glutamate transmembrane transport	SLC7A11; solute carrier family 7 (L-type amino acid transporter), member 11; K13869	solute carrier family 7 member 11 [Source:HGNC Symbol%3BAcc:HGNC:11059]
ENSG00000125995	153.48	133.06	130.22	152.34	161.89	164.44	-0.18514802591676	5.28704357169533	0.0198707580308578	0.174933134352509	20:35699271-35700984:+	ROMO1	15;GO:0001302,biological_process replicative cell aging;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031640,biological_process killing of cells of other organism;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0042742,biological_process defense response to bacterium;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051715,biological_process cytolysis in other organism;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	NA	reactive oxygen species modulator 1 [Source:HGNC Symbol%3BAcc:HGNC:16185]
ENSG00000129968	27.62	27.06	28.05	26.57	22.02	24.06	0.200114254150694	4.84249822789196	0.0198901278499534	0.174979558470213	19:1876809-1885547:-	ABHD17A	5;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity	NA	abhydrolase domain containing 17A [Source:HGNC Symbol%3BAcc:HGNC:28756]
ENSG00000165169	38.26	38.83	35.37	33.06	32.22	32.62	0.208741078329092	4.24931922612213	0.0200258661486266	0.17604892103605	X:37836756-37847637:-	DYNLT3	17;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0030286,cellular_component dynein complex;GO:0042802,molecular_function identical protein binding;GO:0051301,biological_process cell division	NA	dynein light chain Tctex-type 3 [Source:HGNC Symbol%3BAcc:HGNC:11694]
ENSG00000172785	30.68	27.81	30.01	33.86	34.56	31.90	-0.164974799920423	5.52656189627807	0.020056275021837	0.176059934211572	9:121037-179147:-	CBWD1	2;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding	NA	COBW domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17134]
ENSG00000197852	3.26	3.63	2.12	1.92	1.71	2.31	0.588720678060356	1.34980496848603	0.0200607469742077	0.176059934211572	1:111680629-111755824:-	FAM212B	4;GO:0005634,cellular_component nucleus;GO:0019901,molecular_function protein kinase binding;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity	NA	family with sequence similarity 212 member B [Source:HGNC Symbol%3BAcc:HGNC:28045]
ENSG00000065154	83.28	92.74	77.18	69.87	82.29	70.53	0.195413530102883	6.70792991020496	0.0200696694521369	0.176059934211572	10:124397302-124418976:-	OAT	14;GO:0003824,molecular_function catalytic activity;GO:0004587,molecular_function ornithine-oxo-acid transaminase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0007601,biological_process visual perception;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0034214,biological_process protein hexamerization;GO:0042802,molecular_function identical protein binding;GO:0055129,biological_process L-proline biosynthetic process	rocD, OAT; ornithine--oxo-acid transaminase [EC:2.6.1.13]; K00819	ornithine aminotransferase [Source:HGNC Symbol%3BAcc:HGNC:8091]
ENSG00000155085	1.67	2.03	1.53	2.20	2.05	2.14	-0.292089551613602	3.60529559500622	0.0201425689936517	0.176574653190818	6:109492855-109691217:-	AK9	29;GO:0000166,molecular_function nucleotide binding;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006174,biological_process dADP phosphorylation;GO:0006186,biological_process dGDP phosphorylation;GO:0006756,biological_process AMP phosphorylation;GO:0006757,biological_process ATP generation from ADP;GO:0009117,biological_process nucleotide metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0031965,cellular_component nuclear membrane;GO:0050145,molecular_function nucleoside phosphate kinase activity;GO:0061508,biological_process CDP phosphorylation;GO:0061565,biological_process dAMP phosphorylation;GO:0061566,biological_process CMP phosphorylation;GO:0061567,biological_process dCMP phosphorylation;GO:0061568,biological_process GDP phosphorylation;GO:0061569,biological_process UDP phosphorylation;GO:0061570,biological_process dCDP phosphorylation;GO:0061571,biological_process TDP phosphorylation	NA	adenylate kinase 9 [Source:HGNC Symbol%3BAcc:HGNC:33814]
ENSG00000142227	179.11	200.27	179.22	176.10	159.90	165.39	0.165495896011219	6.61454640112386	0.020166804613914	0.176627852418155	19:48321508-48330553:+	EMP3	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0008219,biological_process cell death;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0032060,biological_process bleb assembly	NA	epithelial membrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:3335]
ENSG00000162407	2.95	4.30	5.21	2.97	2.93	2.71	0.538816597303511	1.76511965726196	0.0201976532444203	0.176627852418155	1:56494746-56645301:-	PLPP3	27;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005912,cellular_component adherens junction;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0008354,biological_process germ cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0034109,biological_process homotypic cell-cell adhesion;GO:0042392,molecular_function sphingosine-1-phosphate phosphatase activity;GO:0042577,molecular_function lipid phosphatase activity;GO:0044328,biological_process canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration;GO:0044329,biological_process canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion;GO:0044330,biological_process canonical Wnt signaling pathway involved in positive regulation of wound healing;GO:0046839,biological_process phospholipid dephosphorylation;GO:0050821,biological_process protein stabilization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0070062,cellular_component extracellular exosome	PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]; K01080	phospholipid phosphatase 3 [Source:HGNC Symbol%3BAcc:HGNC:9229]
ENSG00000124562	162.90	180.32	163.18	195.65	192.79	182.08	-0.162301301698587	6.62255844221511	0.0202110650420857	0.176627852418155	6:34757405-34773794:+	SNRPC	23;GO:0000243,cellular_component commitment complex;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000395,biological_process mRNA 5'-splice site recognition;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005685,cellular_component U1 snRNP;GO:0008270,molecular_function zinc ion binding;GO:0015030,cellular_component Cajal body;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030619,molecular_function U1 snRNA binding;GO:0030627,molecular_function pre-mRNA 5'-splice site binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0071004,cellular_component U2-type prespliceosome;GO:0071010,cellular_component prespliceosome;GO:1990446,molecular_function U1 snRNP binding	NA	small nuclear ribonucleoprotein polypeptide C [Source:HGNC Symbol%3BAcc:HGNC:11157]
ENSG00000153029	10.36	11.21	12.52	8.78	10.31	8.94	0.295036780592203	3.4219118591946	0.0202202067764406	0.176627852418155	1:181033424-181061938:+	MR1	18;GO:0002367,biological_process cytokine production involved in immune response;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032393,molecular_function MHC class I receptor activity;GO:0032611,biological_process interleukin-1 beta production;GO:0032620,biological_process interleukin-17 production;GO:0042612,cellular_component MHC class I protein complex;GO:0045087,biological_process innate immune response;GO:0050829,biological_process defense response to Gram-negative bacterium	NA	major histocompatibility complex%2C class I-related [Source:HGNC Symbol%3BAcc:HGNC:4975]
ENSG00000132196	18.43	21.89	15.59	13.59	17.50	14.65	0.294850874970358	4.29496480327636	0.0202302963808888	0.176627852418155	1:162790701-162812817:+	HSD17B7	13;GO:0000253,molecular_function 3-keto sterol reductase activity;GO:0004303,molecular_function estradiol 17-beta-dehydrogenase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006703,biological_process estrogen biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]; K13373	hydroxysteroid 17-beta dehydrogenase 7 [Source:HGNC Symbol%3BAcc:HGNC:5215]
ENSG00000136636	66.01	63.88	66.31	60.65	58.83	60.20	0.13919460691846	7.3417171334056	0.0202442557800247	0.176627852418155	1:215567391-215621807:+	KCTD3	1;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:21305]
ENSG00000181315	11.01	10.86	10.62	8.26	9.94	9.15	0.260116834486097	3.60405172270648	0.0202482424869922	0.176627852418155	6:26634382-26659752:-	ZNF322	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 322 [Source:HGNC Symbol%3BAcc:HGNC:23640]
ENSG00000006468	8.25	7.68	9.32	6.93	5.17	8.05	0.338723886790393	3.6562184263122	0.0202804442723601	0.176663475905447	7:13891227-13991425:-	ETV1	16;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007411,biological_process axon guidance;GO:0007517,biological_process muscle organ development;GO:0007638,biological_process mechanosensory behavior;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048935,biological_process peripheral nervous system neuron development	ETV1; ets translocation variant 1; K09431	ETS variant 1 [Source:HGNC Symbol%3BAcc:HGNC:3490]
ENSG00000133393	48.47	43.52	50.28	57.47	48.55	61.02	-0.216604975557941	5.02871729408032	0.0202807905554872	0.176663475905447	16:15865719-15888625:-	FOPNL	14;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0030030,biological_process cell projection organization;GO:0031514,cellular_component motile cilium;GO:0034451,cellular_component centriolar satellite;GO:0034453,biological_process microtubule anchoring;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	FGFR1OP N-terminal like [Source:HGNC Symbol%3BAcc:HGNC:26435]
ENSG00000011478	36.55	35.77	34.42	31.56	33.35	30.99	0.166723021108036	5.27971765293171	0.0202957695391024	0.176669977060924	19:45692482-45703989:+	QPCTL	10;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016603,molecular_function glutaminyl-peptide cyclotransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017186,biological_process peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase;GO:0046872,molecular_function metal ion binding	NA	glutaminyl-peptide cyclotransferase like [Source:HGNC Symbol%3BAcc:HGNC:25952]
ENSG00000162607	42.42	42.14	42.95	49.13	46.07	47.10	-0.146215700894742	6.73057432610245	0.0204224720527894	0.177648315060459	1:62436296-62451804:+	USP1	20;GO:0001501,biological_process skeletal system development;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006282,biological_process regulation of DNA repair;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0009411,biological_process response to UV;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0035520,biological_process monoubiquitinated protein deubiquitination;GO:0036297,biological_process interstrand cross-link repair;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042769,biological_process DNA damage response, detection of DNA damage	USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]; K11832	ubiquitin specific peptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:12607]
ENSG00000108587	25.07	22.58	26.47	31.20	26.58	29.30	-0.215112766422271	4.57139091864217	0.0204442971241969	0.177713627592897	17:30477361-30527592:+	GOSR1	19;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005794,cellular_component Golgi apparatus;GO:0005797,cellular_component Golgi medial cisterna;GO:0005801,cellular_component cis-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0006906,biological_process vesicle fusion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0031201,cellular_component SNARE complex;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0048209,biological_process regulation of vesicle targeting, to, from or within Golgi	GOSR1, GOS1; golgi SNAP receptor complex member 1; K08495	golgi SNAP receptor complex member 1 [Source:HGNC Symbol%3BAcc:HGNC:4430]
ENSG00000101019	31.30	29.67	25.81	33.66	32.09	34.26	-0.19414915944044	5.09571648323889	0.0204709321952654	0.177820630748656	20:35302565-35412141:-	UQCC1	7;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly;GO:0070131,biological_process positive regulation of mitochondrial translation	NA	ubiquinol-cytochrome c reductase complex assembly factor 1 [Source:HGNC Symbol%3BAcc:HGNC:15891]
ENSG00000212127	1.63	2.81	1.63	1.10	1.44	1.11	0.708061995986092	0.721871268090145	0.0205028118154886	0.177973009136825	12:10937405-11171573:-	TAS2R14	12;GO:0001580,biological_process detection of chemical stimulus involved in sensory perception of bitter taste;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008527,molecular_function taste receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033038,molecular_function bitter taste receptor activity;GO:0050896,biological_process response to stimulus;GO:0050909,biological_process sensory perception of taste	TAS2R; taste receptor type 2; K08474	taste 2 receptor member 14 [Source:HGNC Symbol%3BAcc:HGNC:14920]
ENSG00000137801	108.94	123.94	102.33	88.82	111.54	90.09	0.218146118795184	8.51697300539847	0.0205230212083465	0.17802394287855	15:39581078-39599466:+	THBS1	98;GO:0000187,biological_process activation of MAPK activity;GO:0001666,biological_process response to hypoxia;GO:0001786,molecular_function phosphatidylserine binding;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0001968,molecular_function fibronectin binding;GO:0002040,biological_process sprouting angiogenesis;GO:0002544,biological_process chronic inflammatory response;GO:0002576,biological_process platelet degranulation;GO:0002581,biological_process negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002605,biological_process negative regulation of dendritic cell antigen processing and presentation;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005577,cellular_component fibrinogen complex;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0006986,biological_process response to unfolded protein;GO:0007050,biological_process cell cycle arrest;GO:0007155,biological_process cell adhesion;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009612,biological_process response to mechanical stimulus;GO:0009749,biological_process response to glucose;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0010748,biological_process negative regulation of plasma membrane long-chain fatty acid transport;GO:0010751,biological_process negative regulation of nitric oxide mediated signal transduction;GO:0010754,biological_process negative regulation of cGMP-mediated signaling;GO:0010757,biological_process negative regulation of plasminogen activation;GO:0010759,biological_process positive regulation of macrophage chemotaxis;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0016477,biological_process cell migration;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0017134,molecular_function fibroblast growth factor binding;GO:0018149,biological_process peptide cross-linking;GO:0030141,cellular_component secretory granule;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030194,biological_process positive regulation of blood coagulation;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030823,biological_process regulation of cGMP metabolic process;GO:0031012,cellular_component extracellular matrix;GO:0031091,cellular_component platelet alpha granule;GO:0031093,cellular_component platelet alpha granule lumen;GO:0032026,biological_process response to magnesium ion;GO:0032570,biological_process response to progesterone;GO:0032695,biological_process negative regulation of interleukin-12 production;GO:0032914,biological_process positive regulation of transforming growth factor beta1 production;GO:0033574,biological_process response to testosterone;GO:0034605,biological_process cellular response to heat;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036066,biological_process protein O-linked fucosylation;GO:0040037,biological_process negative regulation of fibroblast growth factor receptor signaling pathway;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042493,biological_process response to drug;GO:0042535,biological_process positive regulation of tumor necrosis factor biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0043032,biological_process positive regulation of macrophage activation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043236,molecular_function laminin binding;GO:0043394,molecular_function proteoglycan binding;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0043537,biological_process negative regulation of blood vessel endothelial cell migration;GO:0043652,biological_process engulfment of apoptotic cell;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045727,biological_process positive regulation of translation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048266,biological_process behavioral response to pain;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050431,molecular_function transforming growth factor beta binding;GO:0050840,molecular_function extracellular matrix binding;GO:0050921,biological_process positive regulation of chemotaxis;GO:0051592,biological_process response to calcium ion;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051918,biological_process negative regulation of fibrinolysis;GO:0070051,molecular_function fibrinogen binding;GO:0070052,molecular_function collagen V binding;GO:0070062,cellular_component extracellular exosome;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071636,biological_process positive regulation of transforming growth factor beta production;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2001027,biological_process negative regulation of endothelial cell chemotaxis;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	THBS1; thrombospondin 1; K16857	thrombospondin 1 [Source:HGNC Symbol%3BAcc:HGNC:11785]
ENSG00000119772	3.07	2.82	3.02	1.98	2.40	2.74	0.337467355196854	2.97093789105933	0.0205601935915579	0.17822184570671	2:25227854-25342590:-	DNMT3A	48;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000791,cellular_component euchromatin;GO:0000792,cellular_component heterochromatin;GO:0001741,cellular_component XY body;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003886,molecular_function DNA (cytosine-5-)-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005720,cellular_component nuclear heterochromatin;GO:0005737,cellular_component cytoplasm;GO:0006306,biological_process DNA methylation;GO:0006346,biological_process methylation-dependent chromatin silencing;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0007283,biological_process spermatogenesis;GO:0007568,biological_process aging;GO:0008168,molecular_function methyltransferase activity;GO:0009008,molecular_function DNA-methyltransferase activity;GO:0009636,biological_process response to toxic substance;GO:0010212,biological_process response to ionizing radiation;GO:0010288,biological_process response to lead ion;GO:0010468,biological_process regulation of gene expression;GO:0010942,biological_process positive regulation of cell death;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0030182,biological_process neuron differentiation;GO:0031667,biological_process response to nutrient levels;GO:0032259,biological_process methylation;GO:0032355,biological_process response to estradiol;GO:0032776,biological_process DNA methylation on cytosine;GO:0033189,biological_process response to vitamin A;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0043045,biological_process DNA methylation involved in embryo development;GO:0043046,biological_process DNA methylation involved in gamete generation;GO:0045471,biological_process response to ethanol;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071361,biological_process cellular response to ethanol;GO:0071456,biological_process cellular response to hypoxia;GO:0090116,biological_process C-5 methylation of cytosine;GO:0097284,biological_process hepatocyte apoptotic process	DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]; K17398	DNA methyltransferase 3 alpha [Source:HGNC Symbol%3BAcc:HGNC:2978]
ENSG00000117480	2.20	1.49	2.03	1.64	1.31	1.01	0.563619930507797	1.5673078542921	0.0205942040871746	0.178317796762005	1:46394264-46413848:+	FAAH	16;GO:0004040,molecular_function amidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005856,cellular_component cytoskeleton;GO:0009062,biological_process fatty acid catabolic process;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017064,molecular_function fatty acid amide hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0031090,cellular_component organelle membrane;GO:0047372,molecular_function acylglycerol lipase activity;GO:0102077,molecular_function oleamide hydrolase activity;GO:0103073,molecular_function anandamide amidohydrolase activity	FAAH; fatty acid amide hydrolase [EC:3.5.1.99]; K15528	fatty acid amide hydrolase [Source:HGNC Symbol%3BAcc:HGNC:3553]
ENSG00000154783	1.52	0.88	1.30	1.07	0.67	0.88	0.524979250712078	2.31728660454218	0.0205999935999931	0.178317796762005	3:14810852-14934565:+	FGD5	24;GO:0001726,cellular_component ruffle;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0031267,molecular_function small GTPase binding;GO:0032587,cellular_component ruffle membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046847,biological_process filopodium assembly;GO:0046872,molecular_function metal ion binding	NA	FYVE%2C RhoGEF and PH domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:19117]
ENSG00000104960	55.12	57.34	51.82	43.46	53.45	48.98	0.182007925189958	6.35866280449851	0.0207693677693755	0.179658649561852	19:49850734-49860744:+	PTOV1	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	prostate tumor overexpressed 1 [Source:HGNC Symbol%3BAcc:HGNC:9632]
ENSG00000175348	33.60	35.91	35.57	30.86	32.29	28.66	0.205365635319447	4.44437152980338	0.0207988307202583	0.17978822126084	11:8947293-8965011:-	TMEM9B	9;GO:0004871,molecular_function signal transducer activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031901,cellular_component early endosome membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling	NA	TMEM9 domain family member B [Source:HGNC Symbol%3BAcc:HGNC:1168]
ENSG00000167619	1.67	1.25	1.97	1.06	0.92	1.37	0.572970134922467	1.47773010643653	0.021023161449404	0.181600906799897	19:42313324-42325062:+	TMEM145	4;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019236,biological_process response to pheromone	NA	transmembrane protein 145 [Source:HGNC Symbol%3BAcc:HGNC:26912]
ENSG00000109519	64.44	64.00	61.84	78.32	66.06	72.80	-0.179662033523879	5.4730918587094	0.0210797838109133	0.181863468607231	4:7058905-7068197:-	GRPEL1	11;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0001405,cellular_component presequence translocase-associated import motor;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006457,biological_process protein folding;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0042803,molecular_function protein homodimerization activity;GO:0050790,biological_process regulation of catalytic activity;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding	NA	GrpE like 1%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:19696]
ENSG00000197943	6.20	5.57	6.54	8.04	6.42	7.22	-0.227560492588406	4.68674474529984	0.0210828592061392	0.181863468607231	16:81739096-81962693:+	PLCG2	36;GO:0001784,molecular_function phosphotyrosine binding;GO:0002092,biological_process positive regulation of receptor internalization;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002316,biological_process follicular B cell differentiation;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0009395,biological_process phospholipid catabolic process;GO:0010468,biological_process regulation of gene expression;GO:0016042,biological_process lipid catabolic process;GO:0016055,biological_process Wnt signaling pathway;GO:0016787,molecular_function hydrolase activity;GO:0019722,biological_process calcium-mediated signaling;GO:0030168,biological_process platelet activation;GO:0030183,biological_process B cell differentiation;GO:0032237,biological_process activation of store-operated calcium channel activity;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032496,biological_process response to lipopolysaccharide;GO:0032959,biological_process inositol trisphosphate biosynthetic process;GO:0035556,biological_process intracellular signal transduction;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043647,biological_process inositol phosphate metabolic process;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0070062,cellular_component extracellular exosome	PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]; K05859	phospholipase C gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:9066]
ENSG00000105136	9.77	10.58	11.15	11.90	11.57	13.72	-0.231089121990086	4.33269803136876	0.0211017363861336	0.181899898445192	19:57487710-57496097:+	ZNF419	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 419 [Source:HGNC Symbol%3BAcc:HGNC:20648]
ENSG00000119403	10.99	9.44	9.20	11.19	13.01	11.05	-0.234083727032014	4.41502502744054	0.021156335413826	0.182243991319793	9:120855651-120894896:-	PHF19	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0019827,biological_process stem cell population maintenance;GO:0035064,molecular_function methylated histone binding;GO:0035098,cellular_component ESC/E(Z) complex;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0048863,biological_process stem cell differentiation;GO:0061087,biological_process positive regulation of histone H3-K27 methylation	NA	PHD finger protein 19 [Source:HGNC Symbol%3BAcc:HGNC:24566]
ENSG00000156976	299.89	306.73	295.24	263.66	286.37	275.67	0.138883843894123	8.47093895533446	0.0212328384272008	0.182669617128964	3:186783204-186789900:+	EIF4A2	22;GO:0000166,molecular_function nucleotide binding;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016032,biological_process viral process;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:1900260,biological_process negative regulation of RNA-directed RNA polymerase activity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol%3BAcc:HGNC:3284]
ENSG00000180304	59.96	61.71	56.55	50.92	57.02	50.66	0.178430551611976	5.23530262532403	0.0212567054271752	0.182669617128964	15:64687572-64703281:-	OAZ2	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0008073,molecular_function ornithine decarboxylase inhibitor activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:1902268,biological_process negative regulation of polyamine transmembrane transport	NA	ornithine decarboxylase antizyme 2 [Source:HGNC Symbol%3BAcc:HGNC:8096]
ENSG00000079263	3.02	4.26	3.87	4.48	4.51	4.82	-0.312418850000854	3.52791649516889	0.0212631473155302	0.182669617128964	2:230203109-230313215:+	SP140	14;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006952,biological_process defense response;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0046872,molecular_function metal ion binding	NA	SP140 nuclear body protein [Source:HGNC Symbol%3BAcc:HGNC:17133]
ENSG00000163453	449.97	458.36	426.35	375.85	436.76	390.95	0.160793002485401	8.49847503260534	0.0212646094216831	0.182669617128964	4:57030772-57110385:-	IGFBP7	20;GO:0001558,biological_process regulation of cell growth;GO:0005515,molecular_function protein binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0007566,biological_process embryo implantation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009408,biological_process response to heat;GO:0014070,biological_process response to organic cyclic compound;GO:0019838,molecular_function growth factor binding;GO:0031012,cellular_component extracellular matrix;GO:0032526,biological_process response to retinoic acid;GO:0032870,biological_process cellular response to hormone stimulus;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0050810,biological_process regulation of steroid biosynthetic process;GO:0051414,biological_process response to cortisol;GO:0070062,cellular_component extracellular exosome	NA	insulin like growth factor binding protein 7 [Source:HGNC Symbol%3BAcc:HGNC:5476]
ENSG00000162105	6.69	6.65	7.30	8.26	7.60	7.57	-0.169111469441617	5.50837191224752	0.0213359964345818	0.183156102173212	11:70467855-71252577:-	SHANK2	39;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005883,cellular_component neurofilament;GO:0005886,cellular_component plasma membrane;GO:0007416,biological_process synapse assembly;GO:0007420,biological_process brain development;GO:0007584,biological_process response to nutrient;GO:0007612,biological_process learning;GO:0007613,biological_process memory;GO:0008022,molecular_function protein C-terminus binding;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030054,cellular_component cell junction;GO:0030160,molecular_function GKAP/Homer scaffold activity;GO:0030426,cellular_component growth cone;GO:0030534,biological_process adult behavior;GO:0031526,cellular_component brush border membrane;GO:0035176,biological_process social behavior;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035640,biological_process exploration behavior;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048786,cellular_component presynaptic active zone;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060170,cellular_component ciliary membrane;GO:0060291,biological_process long-term synaptic potentiation;GO:0060292,biological_process long term synaptic depression;GO:0071625,biological_process vocalization behavior	SHANK; SH3 and multiple ankyrin repeat domains protein; K15009	SH3 and multiple ankyrin repeat domains 2 [Source:HGNC Symbol%3BAcc:HGNC:14295]
ENSG00000145725	18.25	19.16	16.78	20.24	21.19	19.63	-0.162736640664307	6.29536947618756	0.0213608256833541	0.18324252191256	5:103120148-103212799:+	PPIP5K2	19;GO:0000166,molecular_function nucleotide binding;GO:0000827,molecular_function inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828,molecular_function inositol hexakisphosphate kinase activity;GO:0000829,molecular_function inositol heptakisphosphate kinase activity;GO:0000832,molecular_function inositol hexakisphosphate 5-kinase activity;GO:0003993,molecular_function acid phosphatase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006020,biological_process inositol metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0032958,biological_process inositol phosphate biosynthetic process;GO:0033857,molecular_function diphosphoinositol-pentakisphosphate kinase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0052723,molecular_function inositol hexakisphosphate 1-kinase activity;GO:0052724,molecular_function inositol hexakisphosphate 3-kinase activity	PPIP5K, VIP; inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase [EC:2.7.4.24]; K13024	diphosphoinositol pentakisphosphate kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:29035]
ENSG00000171492	36.60	33.04	37.77	40.66	39.63	40.54	-0.155611916816339	6.61804137219281	0.0214216625299769	0.183637497917543	1:89821013-89936611:+	LRRC8D	16;GO:0005225,molecular_function volume-sensitive anion channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034702,cellular_component ion channel complex;GO:0044070,biological_process regulation of anion transport;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	leucine rich repeat containing 8 family member D [Source:HGNC Symbol%3BAcc:HGNC:16992]
ENSG00000129566	4.54	4.81	4.52	3.82	4.52	3.91	0.190014126502514	5.10535745453969	0.0214679536436472	0.183907321310278	14:20365666-20413429:-	TEP1	20;GO:0000166,molecular_function nucleotide binding;GO:0000722,biological_process telomere maintenance via recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0002039,molecular_function p53 binding;GO:0003720,molecular_function telomerase activity;GO:0003723,molecular_function RNA binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005682,cellular_component U5 snRNP;GO:0005694,cellular_component chromosome;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0006278,biological_process RNA-dependent DNA biosynthetic process;GO:0008380,biological_process RNA splicing;GO:0016363,cellular_component nuclear matrix;GO:0019899,molecular_function enzyme binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070034,molecular_function telomerase RNA binding;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	telomerase associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11726]
ENSG00000162946	0.59	0.51	0.89	1.07	1.11	0.83	-0.559663567962222	1.51622586230216	0.0214954838019862	0.18401616581659	1:231626814-232041272:+	DISC1	55;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001764,biological_process neuron migration;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008021,cellular_component synaptic vesicle;GO:0008104,biological_process protein localization;GO:0010975,biological_process regulation of neuron projection development;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0019894,molecular_function kinesin binding;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0021846,biological_process cell proliferation in forebrain;GO:0021852,biological_process pyramidal neuron migration;GO:0030054,cellular_component cell junction;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030286,cellular_component dynein complex;GO:0030424,cellular_component axon;GO:0031929,biological_process TOR signaling;GO:0032403,molecular_function protein complex binding;GO:0032947,molecular_function protein complex scaffold;GO:0034613,biological_process cellular protein localization;GO:0036064,cellular_component ciliary basal body;GO:0044297,cellular_component cell body;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045773,biological_process positive regulation of axon extension;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0051602,biological_process response to electrical stimulus;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060271,biological_process cilium morphogenesis;GO:0060998,biological_process regulation of dendritic spine development;GO:0071539,biological_process protein localization to centrosome;GO:0090128,biological_process regulation of synapse maturation;GO:0090724,cellular_component central region of growth cone;GO:0097546,cellular_component ciliary base;GO:1905515,biological_process non-motile cilium assembly;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	disrupted in schizophrenia 1 [Source:HGNC Symbol%3BAcc:HGNC:2888]
ENSG00000186812	5.64	4.87	6.11	4.92	4.03	4.66	0.309454057623807	3.28706594442181	0.0215418333558976	0.184285856269302	18:35241029-35267133:+	ZNF397	13;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0015630,cellular_component microtubule cytoskeleton;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 397 [Source:HGNC Symbol%3BAcc:HGNC:18818]
ENSG00000130783	1.15	0.87	1.05	0.75	0.83	0.37	0.68571364505068	0.926464194583753	0.0215794653531843	0.184480649744543	12:122774326-122827528:+	CCDC62	8;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0030331,molecular_function estrogen receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0071392,biological_process cellular response to estradiol stimulus	NA	coiled-coil domain containing 62 [Source:HGNC Symbol%3BAcc:HGNC:30723]
ENSG00000186185	12.35	13.63	10.97	13.75	15.95	13.53	-0.21888031854093	5.1406171548317	0.0216244022103939	0.184619534571245	17:44924708-44947711:-	KIF18B	25;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000166,molecular_function nucleotide binding;GO:0000235,cellular_component astral microtubule;GO:0000278,biological_process mitotic cell cycle;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0007019,biological_process microtubule depolymerization;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0016604,cellular_component nuclear body;GO:0016887,molecular_function ATPase activity;GO:0019894,molecular_function kinesin binding;GO:0035371,cellular_component microtubule plus-end;GO:0051301,biological_process cell division;GO:0051302,biological_process regulation of cell division;GO:1990752,cellular_component microtubule end	NA	kinesin family member 18B [Source:HGNC Symbol%3BAcc:HGNC:27102]
ENSG00000162039	1.00	1.35	2.29	0.95	0.81	1.05	0.737705234605531	0.926495955314998	0.0216254574451454	0.184619534571245	16:1833982-1884294:-	MEIOB	19;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0007129,biological_process synapsis;GO:0007140,biological_process male meiosis;GO:0007141,biological_process male meiosis I;GO:0007144,biological_process female meiosis I;GO:0008310,molecular_function single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0009566,biological_process fertilization;GO:0016787,molecular_function hydrolase activity;GO:0051321,biological_process meiotic cell cycle;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	meiosis specific with OB domains [Source:HGNC Symbol%3BAcc:HGNC:28569]
ENSG00000070814	14.78	14.36	14.12	16.92	15.51	15.97	-0.150054332475003	6.13713775611549	0.0216814765532111	0.184970562512034	5:150357638-150400308:+	TCOF1	14;GO:0001042,molecular_function RNA polymerase I core binding;GO:0001501,biological_process skeletal system development;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0014029,biological_process neural crest formation;GO:0014032,biological_process neural crest cell development;GO:0046982,molecular_function protein heterodimerization activity	TCOF1; Treacher Collins syndrome protein; K14562	treacle ribosome biogenesis factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11654]
ENSG00000003436	102.57	106.90	101.57	91.26	97.78	93.85	0.147617333212087	6.68387263012044	0.0218072941655194	0.185916169283374	2:187464229-187565760:-	TFPI	21;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0007596,biological_process blood coagulation;GO:0007598,biological_process blood coagulation, extrinsic pathway;GO:0007599,biological_process hemostasis;GO:0009986,cellular_component cell surface;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031090,cellular_component organelle membrane;GO:0031225,cellular_component anchored component of membrane;GO:0032355,biological_process response to estradiol;GO:0032496,biological_process response to lipopolysaccharide;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1	TFPI; tissue factor pathway inhibitor; K03909	tissue factor pathway inhibitor [Source:HGNC Symbol%3BAcc:HGNC:11760]
ENSG00000163755	53.58	51.37	50.90	47.38	44.22	49.96	0.150570197434274	7.22446833733523	0.0220323141433033	0.187705638614155	3:149129583-149173732:+	HPS3	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006996,biological_process organelle organization;GO:0031084,cellular_component BLOC-2 complex;GO:0043473,biological_process pigmentation	NA	HPS3%2C biogenesis of lysosomal organelles complex 2 subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:15597]
ENSG00000119777	34.63	37.92	33.17	31.00	33.67	30.07	0.167600883363502	6.24545371304504	0.0220534411841129	0.187756766404934	2:27032909-27041695:+	TMEM214	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 214 [Source:HGNC Symbol%3BAcc:HGNC:25983]
ENSG00000162144	26.74	28.19	28.38	25.39	25.63	20.91	0.224200248079084	4.4846418460605	0.0221031184288572	0.188050725878961	11:61348744-61362299:-	CYB561A3	10;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031902,cellular_component late endosome membrane;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome b561 family member A3 [Source:HGNC Symbol%3BAcc:HGNC:23014]
ENSG00000079432	12.68	13.00	13.92	11.38	12.69	11.64	0.161087010245299	6.58756526644793	0.0221685056088928	0.188477849399443	19:42268536-42295797:+	CIC	8;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	capicua transcriptional repressor [Source:HGNC Symbol%3BAcc:HGNC:14214]
ENSG00000070770	34.71	28.58	30.98	36.87	35.18	36.30	-0.182801967468268	5.15875428215909	0.0221849928336166	0.188488922685615	16:58157906-58197920:-	CSNK2A2	34;GO:0000166,molecular_function nucleotide binding;GO:0000785,cellular_component chromatin;GO:0001669,cellular_component acrosomal vesicle;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006457,biological_process protein folding;GO:0006468,biological_process protein phosphorylation;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0016055,biological_process Wnt signaling pathway;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0021987,biological_process cerebral cortex development;GO:0031519,cellular_component PcG protein complex;GO:0047485,molecular_function protein N-terminus binding;GO:0051726,biological_process regulation of cell cycle;GO:0071174,biological_process mitotic spindle checkpoint;GO:0097421,biological_process liver regeneration;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]; K03097	casein kinase 2 alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:2459]
ENSG00000148842	4.41	5.25	4.51	3.69	4.36	3.62	0.28339711336244	3.52797593114376	0.0223734288587297	0.189959899058421	10:102918292-103090221:+	CNNM2	12;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0010960,biological_process magnesium ion homeostasis;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:1903830,biological_process magnesium ion transmembrane transport	NA	cyclin and CBS domain divalent metal cation transport mediator 2 [Source:HGNC Symbol%3BAcc:HGNC:103]
ENSG00000105971	389.72	390.45	390.86	360.67	359.85	356.01	0.133128547584404	7.62157158206229	0.0223963980110765	0.19002494088277	7:116287379-116508541:+	CAV2	45;GO:0000139,cellular_component Golgi membrane;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002080,cellular_component acrosomal membrane;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0005925,cellular_component focal adhesion;GO:0006906,biological_process vesicle fusion;GO:0007005,biological_process mitochondrion organization;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016050,biological_process vesicle organization;GO:0019065,biological_process receptor-mediated endocytosis of virus by host cell;GO:0019901,molecular_function protein kinase binding;GO:0030133,cellular_component transport vesicle;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030674,molecular_function protein binding, bridging;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032947,molecular_function protein complex scaffold;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044791,biological_process positive regulation by host of viral release from host cell;GO:0044794,biological_process positive regulation by host of viral process;GO:0045121,cellular_component membrane raft;GO:0046982,molecular_function protein heterodimerization activity;GO:0048278,biological_process vesicle docking;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048741,biological_process skeletal muscle fiber development;GO:0051259,biological_process protein oligomerization;GO:0060161,biological_process positive regulation of dopamine receptor signaling pathway;GO:0070836,biological_process caveola assembly;GO:0097110,molecular_function scaffold protein binding	CAV2; caveolin 2; K12958	caveolin 2 [Source:HGNC Symbol%3BAcc:HGNC:1528]
ENSG00000101680	0.10	0.07	0.09	0.14	0.15	0.16	-0.772681150886461	0.382824402480191	0.0224156555437827	0.190058423678261	18:6941743-7117814:-	LAMA1	18;GO:0005102,molecular_function receptor binding;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005606,cellular_component laminin-1 complex;GO:0005608,cellular_component laminin-3 complex;GO:0005615,cellular_component extracellular space;GO:0007155,biological_process cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0030155,biological_process regulation of cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030334,biological_process regulation of cell migration;GO:0031012,cellular_component extracellular matrix;GO:0045995,biological_process regulation of embryonic development	LAMA1_2; laminin, alpha 1/2; K05637	laminin subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:6481]
ENSG00000183722	5.53	6.85	6.13	4.37	5.06	3.87	0.480016193017569	1.7215886015323	0.022462406253901	0.190324811487832	13:39342891-39603528:-	LHFPL6	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	LHFPL tetraspan subfamily member 6 [Source:HGNC Symbol%3BAcc:HGNC:6586]
ENSG00000102172	175.10	174.92	164.14	194.27	184.24	192.35	-0.139477187822159	8.00714369144397	0.0224792568158077	0.19033766361161	X:21940572-21994835:+	SMS	9;GO:0005829,cellular_component cytosol;GO:0006555,biological_process methionine metabolic process;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0006597,biological_process spermine biosynthetic process;GO:0008215,biological_process spermine metabolic process;GO:0016740,molecular_function transferase activity;GO:0016768,molecular_function spermine synthase activity;GO:0070062,cellular_component extracellular exosome	SMS; spermine synthase [EC:2.5.1.22]; K00802	spermine synthase [Source:HGNC Symbol%3BAcc:HGNC:11123]
ENSG00000105499	1.52	1.34	1.83	1.21	1.02	1.06	0.532087295598123	1.39076742456836	0.0224982762488316	0.190368850086398	19:48047842-48110817:-	PLA2G4C	23;GO:0004620,molecular_function phospholipase activity;GO:0004622,molecular_function lysophospholipase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005543,molecular_function phospholipid binding;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006954,biological_process inflammatory response;GO:0007567,biological_process parturition;GO:0008152,biological_process metabolic process;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0009395,biological_process phospholipid catabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0035556,biological_process intracellular signal transduction;GO:0036149,biological_process phosphatidylinositol acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0047499,molecular_function calcium-independent phospholipase A2 activity	PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]; K16342	phospholipase A2 group IVC [Source:HGNC Symbol%3BAcc:HGNC:9037]
ENSG00000196504	36.72	39.04	36.89	41.39	42.08	41.88	-0.143816071227001	6.87066842744864	0.0226015941373695	0.191112798383629	2:152651592-152717997:-	PRPF40A	20;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005685,cellular_component U1 snRNP;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0008360,biological_process regulation of cell shape;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0016477,biological_process cell migration;GO:0016607,cellular_component nuclear speck;GO:0032465,biological_process regulation of cytokinesis;GO:0051301,biological_process cell division;GO:0070064,molecular_function proline-rich region binding;GO:0071004,cellular_component U2-type prespliceosome	PRPF40, PRP40; pre-mRNA-processing factor 40; K12821	pre-mRNA processing factor 40 homolog A [Source:HGNC Symbol%3BAcc:HGNC:16463]
ENSG00000145819	6.93	6.12	5.54	8.27	6.38	7.94	-0.268424537546891	4.30219053740531	0.0226318819788949	0.191146812414995	5:142770383-143229011:+	ARHGAP26	14;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 26 [Source:HGNC Symbol%3BAcc:HGNC:17073]
ENSG00000133019	0.88	0.65	0.50	0.89	1.11	1.27	-0.671630303107874	0.794195877630094	0.0226364145855186	0.191146812414995	1:239386564-239915452:+	CHRM3	34;GO:0003056,biological_process regulation of vascular smooth muscle contraction;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0006939,biological_process smooth muscle contraction;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007197,biological_process adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway;GO:0007207,biological_process phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0007399,biological_process nervous system development;GO:0007586,biological_process digestion;GO:0008144,molecular_function drug binding;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016907,molecular_function G-protein coupled acetylcholine receptor activity;GO:0019229,biological_process regulation of vasoconstriction;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0032279,cellular_component asymmetric synapse;GO:0042166,molecular_function acetylcholine binding;GO:0043679,cellular_component axon terminus;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046541,biological_process saliva secretion	CHRM3; muscarinic acetylcholine receptor M3; K04131	cholinergic receptor muscarinic 3 [Source:HGNC Symbol%3BAcc:HGNC:1952]
ENSG00000140612	279.71	285.21	265.55	254.82	251.06	254.49	0.1383873575215	7.5562891583564	0.0226708578994221	0.191307518086693	15:84669537-84716716:-	SEC11A	13;GO:0005783,cellular_component endoplasmic reticulum;GO:0005787,cellular_component signal peptidase complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome	SEC11, sipW; signal peptidase I [EC:3.4.21.89]; K13280	SEC11 homolog A%2C signal peptidase complex subunit [Source:HGNC Symbol%3BAcc:HGNC:17718]
ENSG00000259207	3.48	3.26	3.24	2.25	2.84	2.95	0.325199048783493	2.89733302667091	0.0227215062411118	0.191604658268288	17:47253845-47311816:+	ITGB3	77;GO:0001618,molecular_function virus receptor activity;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001968,molecular_function fibronectin binding;GO:0002020,molecular_function protease binding;GO:0002576,biological_process platelet degranulation;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0004872,molecular_function receptor activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007044,biological_process cell-substrate junction assembly;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007596,biological_process blood coagulation;GO:0008305,cellular_component integrin complex;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010888,biological_process negative regulation of lipid storage;GO:0014909,biological_process smooth muscle cell migration;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016049,biological_process cell growth;GO:0016477,biological_process cell migration;GO:0017134,molecular_function fibroblast growth factor binding;GO:0019899,molecular_function enzyme binding;GO:0019960,molecular_function C-X3-C chemokine binding;GO:0030054,cellular_component cell junction;GO:0030168,biological_process platelet activation;GO:0030198,biological_process extracellular matrix organization;GO:0030334,biological_process regulation of cell migration;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031092,cellular_component platelet alpha granule membrane;GO:0031258,cellular_component lamellipodium membrane;GO:0031527,cellular_component filopodium membrane;GO:0031528,cellular_component microvillus membrane;GO:0031589,biological_process cell-substrate adhesion;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0032147,biological_process activation of protein kinase activity;GO:0032369,biological_process negative regulation of lipid transport;GO:0032587,cellular_component ruffle membrane;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0034683,cellular_component integrin alphav-beta3 complex;GO:0035295,biological_process tube development;GO:0035867,cellular_component alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0038027,biological_process apolipoprotein A-I-mediated signaling pathway;GO:0038132,molecular_function neuregulin binding;GO:0042060,biological_process wound healing;GO:0042470,cellular_component melanosome;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043184,molecular_function vascular endothelial growth factor receptor 2 binding;GO:0043235,cellular_component receptor complex;GO:0045124,biological_process regulation of bone resorption;GO:0045715,biological_process negative regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0046718,biological_process viral entry into host cell;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048333,biological_process mesodermal cell differentiation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050748,biological_process negative regulation of lipoprotein metabolic process;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050840,molecular_function extracellular matrix binding;GO:0050900,biological_process leukocyte migration;GO:0050919,biological_process negative chemotaxis;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0071062,cellular_component alphav-beta3 integrin-vitronectin complex	ITGB3, CD61; integrin beta 3; K06493	integrin subunit beta 3 [Source:HGNC Symbol%3BAcc:HGNC:6156]
ENSG00000055609	7.61	8.08	8.51	7.07	7.59	7.26	0.153821869822483	6.84288348773293	0.022810992908061	0.191978169606139	7:152134921-152436005:-	KMT2C	20;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0044666,cellular_component MLL3/4 complex;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0051568,biological_process histone H3-K4 methylation	MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]; K09188	lysine methyltransferase 2C [Source:HGNC Symbol%3BAcc:HGNC:13726]
ENSG00000103253	10.43	12.11	11.61	10.05	8.46	10.03	0.26258474879377	3.6511406809019	0.0228115863496295	0.191978169606139	16:726935-735525:+	HAGHL	4;GO:0004416,molecular_function hydroxyacylglutathione hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0019243,biological_process methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0046872,molecular_function metal ion binding	gloB, gloC, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]; K01069	hydroxyacylglutathione hydrolase like [Source:HGNC Symbol%3BAcc:HGNC:14177]
ENSG00000144118	68.53	67.08	66.43	74.77	76.81	74.29	-0.148458975489361	5.66398266869323	0.0228121969039761	0.191978169606139	2:120240063-120294713:+	RALB	29;GO:0000145,cellular_component exocyst;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0001928,biological_process regulation of exocyst assembly;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005776,cellular_component autophagosome;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0009267,biological_process cellular response to starvation;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030496,cellular_component midbody;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032091,biological_process negative regulation of protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0051117,molecular_function ATPase binding;GO:0051301,biological_process cell division;GO:0060178,biological_process regulation of exocyst localization;GO:0070062,cellular_component extracellular exosome;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:2000786,biological_process positive regulation of autophagosome assembly	RALB; Ras-related protein Ral-B; K07835	RAS like proto-oncogene B [Source:HGNC Symbol%3BAcc:HGNC:9840]
ENSG00000100889	92.90	64.94	91.83	109.52	85.38	111.13	-0.281055687982318	7.77656330037141	0.022842872391847	0.192106080623304	14:24094052-24110598:+	PCK2	23;GO:0000166,molecular_function nucleotide binding;GO:0004611,molecular_function phosphoenolpyruvate carboxykinase activity;GO:0004613,molecular_function phosphoenolpyruvate carboxykinase (GTP) activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006090,biological_process pyruvate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006116,biological_process NADH oxidation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0017076,molecular_function purine nucleotide binding;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032496,biological_process response to lipopolysaccharide;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071548,biological_process response to dexamethasone	E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]; K01596	phosphoenolpyruvate carboxykinase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:8725]
ENSG00000111203	6.11	6.71	4.92	7.66	7.13	7.19	-0.307579527287745	3.30129932274185	0.0228649250958743	0.192145379170645	12:2812621-2859791:+	ITFG2	11;GO:0002314,biological_process germinal center B cell differentiation;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042149,biological_process cellular response to glucose starvation;GO:0140007,cellular_component KICSTOR complex;GO:1904262,biological_process negative regulation of TORC1 signaling	NA	integrin alpha FG-GAP repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30879]
ENSG00000059691	9.59	9.70	9.19	12.09	11.21	10.23	-0.223257671903506	4.19281127010092	0.022888464966458	0.192145379170645	4:151670503-151761023:-	GATB	12;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0016884,molecular_function carbon-nitrogen ligase activity, with glutamine as amido-N-donor;GO:0030956,cellular_component glutamyl-tRNA(Gln) amidotransferase complex;GO:0032543,biological_process mitochondrial translation;GO:0050567,molecular_function glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity;GO:0070681,biological_process glutaminyl-tRNAGln biosynthesis via transamidation	NA	glutamyl-tRNA amidotransferase subunit B [Source:HGNC Symbol%3BAcc:HGNC:8849]
ENSG00000144136	65.15	61.42	64.74	77.58	64.15	75.87	-0.173504438969926	7.16557089402614	0.0228939833878502	0.192145379170645	2:112645856-112663827:+	SLC20A1	23;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0005315,molecular_function inorganic phosphate transmembrane transporter activity;GO:0005316,molecular_function high-affinity inorganic phosphate:sodium symporter activity;GO:0005436,molecular_function sodium:phosphate symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006817,biological_process phosphate ion transport;GO:0007165,biological_process signal transduction;GO:0015293,molecular_function symporter activity;GO:0015319,molecular_function sodium:inorganic phosphate symporter activity;GO:0015321,molecular_function sodium-dependent phosphate transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044341,biological_process sodium-dependent phosphate transport;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 20 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10946]
ENSG00000133466	21.59	21.19	21.18	18.28	17.58	19.84	0.210051532623938	4.16659885710503	0.0229362976806221	0.19226215469769	22:37180166-37199385:-	C1QTNF6	9;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042802,molecular_function identical protein binding;GO:0051259,biological_process protein oligomerization;GO:0070208,biological_process protein heterotrimerization	NA	C1q and TNF related 6 [Source:HGNC Symbol%3BAcc:HGNC:14343]
ENSG00000064102	18.90	19.26	18.24	20.35	20.79	22.43	-0.163739099870634	5.41164236900494	0.0229388746561894	0.19226215469769	12:26905180-26938326:-	INTS13	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0030317,biological_process sperm motility;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0051301,biological_process cell division;GO:0051642,biological_process centrosome localization;GO:0080154,biological_process regulation of fertilization;GO:0090435,biological_process protein localization to nuclear envelope	NA	integrator complex subunit 13 [Source:HGNC Symbol%3BAcc:HGNC:20174]
ENSG00000127914	7.46	7.51	7.54	6.28	7.46	6.47	0.167761417280139	6.42548391687326	0.0230765479934096	0.192949275045211	7:91940866-92110673:+	AKAP9	43;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000165,biological_process MAPK cascade;GO:0003677,molecular_function DNA binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005801,cellular_component cis-Golgi network;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0007020,biological_process microtubule nucleation;GO:0007165,biological_process signal transduction;GO:0007194,biological_process negative regulation of adenylate cyclase activity;GO:0007268,biological_process chemical synaptic transmission;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015459,molecular_function potassium channel regulator activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0032947,molecular_function protein complex scaffold;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044307,cellular_component dendritic branch;GO:0044325,molecular_function ion channel binding;GO:0051602,biological_process response to electrical stimulus;GO:0051661,biological_process maintenance of centrosome location;GO:0060306,biological_process regulation of membrane repolarization;GO:0060307,biological_process regulation of ventricular cardiac muscle cell membrane repolarization;GO:0061337,biological_process cardiac conduction;GO:0071320,biological_process cellular response to cAMP;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0097060,cellular_component synaptic membrane;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0098909,biological_process regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:1901018,biological_process positive regulation of potassium ion transmembrane transporter activity	NA	A-kinase anchoring protein 9 [Source:HGNC Symbol%3BAcc:HGNC:379]
ENSG00000108433	6.69	6.96	6.85	6.48	4.32	5.78	0.315691553404072	3.51263414961828	0.0230813932929763	0.192949275045211	17:46923074-46975524:+	GOSR2	25;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006623,biological_process protein targeting to vacuole;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0006896,biological_process Golgi to vacuole transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031201,cellular_component SNARE complex;GO:0031902,cellular_component late endosome membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0048208,biological_process COPII vesicle coating;GO:0048280,biological_process vesicle fusion with Golgi apparatus;GO:0061025,biological_process membrane fusion	GOSR2, BOS1; golgi SNAP receptor complex member 2; K08496	golgi SNAP receptor complex member 2 [Source:HGNC Symbol%3BAcc:HGNC:4431]
ENSG00000084444	3.36	2.86	2.25	3.85	3.65	3.61	-0.377166578281717	2.65015623865096	0.0231055810540505	0.192949275045211	12:13044283-13142521:+	FAM234B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 234 member B [Source:HGNC Symbol%3BAcc:HGNC:29288]
ENSG00000131153	18.07	17.56	16.05	22.26	18.04	23.95	-0.305242235107368	3.44831097119381	0.0231282411545465	0.192949275045211	16:85676197-85690073:-	GINS2	11;GO:0000727,biological_process double-strand break repair via break-induced replication;GO:0000811,cellular_component GINS complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006271,biological_process DNA strand elongation involved in DNA replication;GO:0031298,cellular_component replication fork protection complex;GO:0032508,biological_process DNA duplex unwinding;GO:0043138,molecular_function 3'-5' DNA helicase activity;GO:1902975,biological_process mitotic DNA replication initiation	NA	GINS complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:24575]
ENSG00000168243	31.08	31.86	26.50	22.96	23.60	24.06	0.345291163348477	2.61474259802536	0.0231292078103247	0.192949275045211	1:235547686-235650754:-	GNG4	11;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016020,cellular_component membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus	GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; K04541	G protein subunit gamma 4 [Source:HGNC Symbol%3BAcc:HGNC:4407]
ENSG00000110756	7.30	7.24	6.85	7.36	9.06	8.44	-0.206470854184088	4.8004109176714	0.0231334911612999	0.192949275045211	11:18278667-18322198:-	HPS5	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006996,biological_process organelle organization;GO:0007596,biological_process blood coagulation;GO:0031084,cellular_component BLOC-2 complex;GO:0043473,biological_process pigmentation	NA	HPS5%2C biogenesis of lysosomal organelles complex 2 subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:17022]
ENSG00000166546	0.46	0.11	0.62	1.39	0.32	0.92	-1.06609376159219	0.324851955986885	0.0231345571052383	0.192949275045211	16:66427296-66493529:+	BEAN1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	brain expressed associated with NEDD4 1 [Source:HGNC Symbol%3BAcc:HGNC:24160]
ENSG00000149499	17.70	17.72	19.00	16.76	15.92	16.65	0.154447576935575	5.67483615719159	0.0231452082931056	0.192949275045211	11:62602217-62612765:-	EML3	5;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton	NA	echinoderm microtubule associated protein like 3 [Source:HGNC Symbol%3BAcc:HGNC:26666]
ENSG00000087111	59.75	59.40	58.55	51.30	58.56	49.98	0.164784014948364	6.63213495864553	0.0231783560224472	0.193095928393717	17:28553382-28571872:-	PIGS	9;GO:0003923,molecular_function GPI-anchor transamidase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016255,biological_process attachment of GPI anchor to protein;GO:0042765,cellular_component GPI-anchor transamidase complex	PIGS; GPI-anchor transamidase subunit S; K05291	phosphatidylinositol glycan anchor biosynthesis class S [Source:HGNC Symbol%3BAcc:HGNC:14937]
ENSG00000165118	34.94	33.71	39.41	39.66	40.17	43.80	-0.179804542801092	5.32141532702069	0.0232336539300269	0.193417949272728	9:83938310-83956986:-	C9orf64	4;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0006400,biological_process tRNA modification;GO:0008150,biological_process biological_process	NA	chromosome 9 open reading frame 64 [Source:HGNC Symbol%3BAcc:HGNC:28144]
ENSG00000082701	33.27	32.08	33.26	35.62	37.72	37.30	-0.15265931535743	5.50854166663291	0.0232570920938276	0.193417949272728	3:119821322-120094417:-	GSK3B	75;GO:0000166,molecular_function nucleotide binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002020,molecular_function protease binding;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0006468,biological_process protein phosphorylation;GO:0006983,biological_process ER overload response;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007623,biological_process circadian rhythm;GO:0008013,molecular_function beta-catenin binding;GO:0009968,biological_process negative regulation of signal transduction;GO:0010822,biological_process positive regulation of mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0021766,biological_process hippocampus development;GO:0030154,biological_process cell differentiation;GO:0030877,cellular_component beta-catenin destruction complex;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032091,biological_process negative regulation of protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032886,biological_process regulation of microtubule-based process;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0035556,biological_process intracellular signal transduction;GO:0036016,biological_process cellular response to interleukin-3;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045719,biological_process negative regulation of glycogen biosynthetic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046777,biological_process protein autophosphorylation;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0048511,biological_process rhythmic process;GO:0050321,molecular_function tau-protein kinase activity;GO:0051059,molecular_function NF-kappaB binding;GO:0051534,biological_process negative regulation of NFAT protein import into nucleus;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0071109,biological_process superior temporal gyrus development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0098794,cellular_component postsynapse;GO:0099565,biological_process chemical synaptic transmission, postsynaptic;GO:1900034,biological_process regulation of cellular response to heat;GO:1900181,biological_process negative regulation of protein localization to nucleus;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1901216,biological_process positive regulation of neuron death;GO:1904339,biological_process negative regulation of dopaminergic neuron differentiation;GO:1904885,biological_process beta-catenin destruction complex assembly;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:1990909,cellular_component Wnt signalosome;GO:2000077,biological_process negative regulation of type B pancreatic cell development;GO:2000466,biological_process negative regulation of glycogen (starch) synthase activity	GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]; K03083	glycogen synthase kinase 3 beta [Source:HGNC Symbol%3BAcc:HGNC:4617]
ENSG00000198003	0.60	1.06	1.37	0.56	0.48	0.75	0.755165940434692	0.72056373760742	0.0232884019878836	0.193417949272728	19:11420603-11435782:-	CCDC151	14;GO:0003341,biological_process cilium movement;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007368,biological_process determination of left/right symmetry;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0036158,biological_process outer dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0070286,biological_process axonemal dynein complex assembly;GO:1902017,biological_process regulation of cilium assembly	NA	coiled-coil domain containing 151 [Source:HGNC Symbol%3BAcc:HGNC:28303]
ENSG00000188827	2.45	3.21	2.18	3.52	3.43	2.84	-0.318756500382233	4.02396137346509	0.02329018954538	0.193417949272728	16:3581180-3611598:-	SLX4	32;GO:0000706,biological_process meiotic DNA double-strand break processing;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000790,cellular_component nuclear chromatin;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008047,molecular_function enzyme activator activity;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0010792,biological_process DNA double-strand break processing involved in repair via single-strand annealing;GO:0017108,molecular_function 5'-flap endonuclease activity;GO:0030054,cellular_component cell junction;GO:0033557,cellular_component Slx1-Slx4 complex;GO:0036297,biological_process interstrand cross-link repair;GO:0043085,biological_process positive regulation of catalytic activity;GO:0048257,molecular_function 3'-flap endonuclease activity;GO:0048476,cellular_component Holliday junction resolvase complex;GO:0061820,biological_process telomeric D-loop disassembly;GO:0070522,cellular_component ERCC4-ERCC1 complex;GO:0072429,biological_process response to intra-S DNA damage checkpoint signaling;GO:0090656,biological_process t-circle formation;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1904431,biological_process positive regulation of t-circle formation	BTBD12, SLX4; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12); K10484	SLX4 structure-specific endonuclease subunit [Source:HGNC Symbol%3BAcc:HGNC:23845]
ENSG00000184967	6.21	6.70	6.21	7.47	7.75	7.60	-0.249208252854994	3.5765335952093	0.0232949193718464	0.193417949272728	12:132144447-132152473:+	NOC4L	13;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030692,cellular_component Noc4p-Nop14p complex;GO:0031965,cellular_component nuclear membrane;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis	NA	nucleolar complex associated 4 homolog [Source:HGNC Symbol%3BAcc:HGNC:28461]
ENSG00000228300	28.36	28.24	28.25	24.01	25.38	25.57	0.190001867528161	4.40847669106106	0.0233353416325735	0.193624061286855	19:1275437-1279249:+	C19orf24	4;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 19 open reading frame 24 [Source:HGNC Symbol%3BAcc:HGNC:26073]
ENSG00000144357	6.84	7.49	7.08	6.08	6.61	6.53	0.163907232699605	5.34082738410855	0.023368907302836	0.193773043654043	2:169827457-170084131:+	UBR3	17;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001701,biological_process in utero embryonic development;GO:0001967,biological_process suckling behavior;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007608,biological_process sensory perception of smell;GO:0008270,molecular_function zinc ion binding;GO:0009790,biological_process embryo development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042048,biological_process olfactory behavior;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071596,biological_process ubiquitin-dependent protein catabolic process via the N-end rule pathway	NA	ubiquitin protein ligase E3 component n-recognin 3 (putative) [Source:HGNC Symbol%3BAcc:HGNC:30467]
ENSG00000133265	29.72	33.30	30.08	35.53	36.06	34.08	-0.17586507812469	5.16564220254341	0.0233994133783541	0.19389647414253	19:55262230-55280381:-	HSPBP1	6;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0006457,biological_process protein folding;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043086,biological_process negative regulation of catalytic activity	HSPBP1, FES1; hsp70-interacting protein; K09562	HSPA (Hsp70) binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24989]
ENSG00000068971	10.09	10.13	9.82	8.64	8.85	8.35	0.22886133572822	3.80885295348567	0.023445394558875	0.194147887030897	11:64917552-64934473:+	PPP2R5B	21;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0010469,biological_process regulation of receptor activity;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031952,biological_process regulation of protein autophosphorylation;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050790,biological_process regulation of catalytic activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051388,biological_process positive regulation of neurotrophin TRK receptor signaling pathway;GO:0070317,biological_process negative regulation of G0 to G1 transition;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071363,biological_process cellular response to growth factor stimulus	PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'; K11584	protein phosphatase 2 regulatory subunit B'beta [Source:HGNC Symbol%3BAcc:HGNC:9310]
ENSG00000196507	29.31	28.35	29.69	23.96	25.53	26.49	0.21412008010208	4.04316544315373	0.023617379412888	0.195441687101453	X:103607450-103629690:+	TCEAL3	5;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0050699,molecular_function WW domain binding	NA	transcription elongation factor A like 3 [Source:HGNC Symbol%3BAcc:HGNC:28247]
ENSG00000140521	14.74	15.41	15.14	14.56	13.62	12.58	0.163264094164114	5.81599013135881	0.023637097226971	0.195474542224111	15:89305197-89334861:-	POLG	27;GO:0002020,molecular_function protease binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005760,cellular_component gamma DNA polymerase complex;GO:0006259,biological_process DNA metabolic process;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006264,biological_process mitochondrial DNA replication;GO:0006287,biological_process base-excision repair, gap-filling;GO:0007568,biological_process aging;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0009416,biological_process response to light stimulus;GO:0010332,biological_process response to gamma radiation;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043195,cellular_component terminal bouton;GO:0043234,cellular_component protein complex;GO:0055093,biological_process response to hyperoxia;GO:0070062,cellular_component extracellular exosome;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071897,biological_process DNA biosynthetic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	DNA polymerase gamma%2C catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9179]
ENSG00000109452	0.65	0.72	0.79	0.93	0.92	1.31	-0.542033923823989	1.52885156342484	0.0237486491213456	0.196266299296447	4:142023159-142847432:-	INPP4B	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016316,molecular_function phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0017161,molecular_function inositol-1,3,4-trisphosphate 4-phosphatase activity;GO:0034597,molecular_function phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0043647,biological_process inositol phosphate metabolic process;GO:0052828,molecular_function inositol-3,4-bisphosphate 4-phosphatase activity	INPP4; inositol polyphosphate-4-phosphatase [EC:3.1.3.66]; K01109	inositol polyphosphate-4-phosphatase type II B [Source:HGNC Symbol%3BAcc:HGNC:6075]
ENSG00000126249	2.37	3.74	4.32	5.16	4.38	4.98	-0.475431134000285	2.20876873480538	0.0237945674880958	0.196514947591306	19:34404383-34426168:+	PDCD2L	3;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane	NA	programmed cell death 2 like [Source:HGNC Symbol%3BAcc:HGNC:28194]
ENSG00000103404	3.84	3.65	3.87	4.57	4.27	4.37	-0.203279892949805	4.2109036026686	0.0238297967763366	0.196675044803635	16:23061405-23149270:-	USP31	9;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 31 [Source:HGNC Symbol%3BAcc:HGNC:20060]
ENSG00000234745	791.42	741.45	799.00	722.33	690.33	729.11	0.134612471829194	9.84703907505044	0.0238925473474994	0.19696464460599	6:31269490-31357188:-	HLA-B	35;GO:0000139,cellular_component Golgi membrane;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002667,biological_process regulation of T cell anergy;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019882,biological_process antigen processing and presentation;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031901,cellular_component early endosome membrane;GO:0032655,biological_process regulation of interleukin-12 production;GO:0032675,biological_process regulation of interleukin-6 production;GO:0042270,biological_process protection from natural killer cell mediated cytotoxicity;GO:0042605,molecular_function peptide antigen binding;GO:0042612,cellular_component MHC class I protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0050776,biological_process regulation of immune response;GO:0055038,cellular_component recycling endosome membrane;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:2001198,biological_process regulation of dendritic cell differentiation	MHC1; MHC class I antigen; K06751	major histocompatibility complex%2C class I%2C B [Source:HGNC Symbol%3BAcc:HGNC:4932]
ENSG00000133739	11.98	11.90	11.72	12.66	14.46	13.23	-0.168817366031178	5.32034451308308	0.0238966208633386	0.19696464460599	8:85107146-85146076:+	LRRCC1	6;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0051301,biological_process cell division	NA	leucine rich repeat and coiled-coil centrosomal protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29373]
ENSG00000100439	56.82	56.49	56.63	52.71	52.02	50.30	0.144594793838586	5.83919486091268	0.0239188392554111	0.197016955326754	14:22598236-22613215:+	ABHD4	5;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling	NA	abhydrolase domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:20154]
ENSG00000079459	93.94	116.42	90.51	84.64	95.64	81.03	0.21365701190464	7.19469451191264	0.023958575275414	0.197213391839333	8:11795572-11839309:+	FDFT1	27;GO:0003824,molecular_function catalytic activity;GO:0004310,molecular_function farnesyl-diphosphate farnesyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006696,biological_process ergosterol biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0008610,biological_process lipid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016740,molecular_function transferase activity;GO:0016765,molecular_function transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0019216,biological_process regulation of lipid metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045338,biological_process farnesyl diphosphate metabolic process;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0051996,molecular_function squalene synthase activity;GO:0055114,biological_process oxidation-reduction process	FDFT1; farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]; K00801	farnesyl-diphosphate farnesyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:3629]
ENSG00000143149	72.90	74.60	72.99	63.84	68.42	68.96	0.142992419041439	6.77356874494811	0.0240521442515674	0.197852396683039	1:165662215-165698863:-	ALDH9A1	15;GO:0004028,molecular_function 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0019145,molecular_function aminobutyraldehyde dehydrogenase activity;GO:0033737,molecular_function 1-pyrroline dehydrogenase activity;GO:0042136,biological_process neurotransmitter biosynthetic process;GO:0042445,biological_process hormone metabolic process;GO:0045329,biological_process carnitine biosynthetic process;GO:0047105,molecular_function 4-trimethylammoniobutyraldehyde dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]; K00149	aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:412]
ENSG00000197329	13.74	13.87	11.91	14.69	15.85	15.81	-0.221940553360661	4.17936116238935	0.0240858968788723	0.197998833084398	2:64092651-64144454:-	PELI1	26;GO:0000209,biological_process protein polyubiquitination;GO:0001819,biological_process positive regulation of cytokine production;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0008063,biological_process Toll signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0034141,biological_process positive regulation of toll-like receptor 3 signaling pathway;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043331,biological_process response to dsRNA;GO:0050868,biological_process negative regulation of T cell activation;GO:0050871,biological_process positive regulation of B cell activation;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination	NA	pellino E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:8827]
ENSG00000186193	11.59	12.29	13.14	13.56	15.85	14.46	-0.232800151240287	4.01027612722643	0.0242414642696308	0.199145794823909	9:137062123-137070588:-	SAPCD2	4;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	suppressor APC domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28055]
ENSG00000181610	69.46	77.27	67.65	82.16	79.35	80.41	-0.167572670664371	5.53098975219481	0.0242596944765941	0.199163748371668	17:57834780-57850056:-	MRPS23	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031965,cellular_component nuclear membrane;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S23 [Source:HGNC Symbol%3BAcc:HGNC:14509]
ENSG00000135525	9.29	12.01	10.89	11.70	14.01	12.38	-0.236678936210155	4.83469940423929	0.0243342271073265	0.199457247689967	6:136342280-136550819:-	MAP7	17;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005102,molecular_function receptor binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0006970,biological_process response to osmotic stress;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0072659,biological_process protein localization to plasma membrane	NA	microtubule associated protein 7 [Source:HGNC Symbol%3BAcc:HGNC:6869]
ENSG00000198331	21.65	23.86	23.63	25.37	27.48	26.97	-0.199122441656902	4.48805884277786	0.0243465901767222	0.199457247689967	11:125883613-125900648:+	HYLS1	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane	NA	HYLS1%2C centriolar and ciliogenesis associated [Source:HGNC Symbol%3BAcc:HGNC:26558]
ENSG00000137494	8.29	7.03	6.99	9.30	9.12	8.34	-0.242792526171572	3.88359437864992	0.0243539983113296	0.199457247689967	11:83193738-83260694:+	ANKRD42	4;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation	NA	ankyrin repeat domain 42 [Source:HGNC Symbol%3BAcc:HGNC:26752]
ENSG00000115364	32.01	36.76	33.59	40.16	37.05	39.25	-0.180553257355018	5.13899148949251	0.0243597186415846	0.199457247689967	2:75646782-75690851:+	MRPL19	12;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031965,cellular_component nuclear membrane;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L19, MRPL19, rplS; large subunit ribosomal protein L19; K02884	mitochondrial ribosomal protein L19 [Source:HGNC Symbol%3BAcc:HGNC:14052]
ENSG00000198753	5.38	4.38	5.42	3.96	4.89	4.22	0.234525653585505	4.84700146947197	0.0244282065360032	0.199886175169023	X:153764195-153779346:+	PLXNB3	24;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0010593,biological_process negative regulation of lamellipodium assembly;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0019904,molecular_function protein domain specific binding;GO:0030336,biological_process negative regulation of cell migration;GO:0034260,biological_process negative regulation of GTPase activity;GO:0048675,biological_process axon extension;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050918,biological_process positive chemotaxis;GO:0051022,molecular_function Rho GDP-dissociation inhibitor binding;GO:0060326,biological_process cell chemotaxis;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0098632,molecular_function protein binding involved in cell-cell adhesion	PLXNB; plexin B; K06821	plexin B3 [Source:HGNC Symbol%3BAcc:HGNC:9105]
ENSG00000135736	5.09	4.29	4.68	5.26	6.25	5.92	-0.289399647786829	3.1481109299908	0.024455917356867	0.199958373240951	16:57512177-57536599:-	CCDC102A	2;GO:0003774,molecular_function motor activity;GO:0016459,cellular_component myosin complex	NA	coiled-coil domain containing 102A [Source:HGNC Symbol%3BAcc:HGNC:28097]
ENSG00000134057	68.28	69.07	60.43	72.13	78.98	72.27	-0.164913406788257	6.69673513759053	0.024469247478692	0.199958373240951	5:69167009-69178245:+	CCNB1	64;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0000942,cellular_component condensed nuclear chromosome outer kinetochore;GO:0001556,biological_process oocyte maturation;GO:0001701,biological_process in utero embryonic development;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005113,molecular_function patched binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006461,biological_process protein complex assembly;GO:0006468,biological_process protein phosphorylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007283,biological_process spermatogenesis;GO:0009612,biological_process response to mechanical stimulus;GO:0009636,biological_process response to toxic substance;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0019901,molecular_function protein kinase binding;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031442,biological_process positive regulation of mRNA 3'-end processing;GO:0031662,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0035173,molecular_function histone kinase activity;GO:0042246,biological_process tissue regeneration;GO:0042493,biological_process response to drug;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0045787,biological_process positive regulation of cell cycle;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046680,biological_process response to DDT;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048565,biological_process digestive tract development;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051726,biological_process regulation of cell cycle;GO:0051987,biological_process positive regulation of attachment of spindle microtubules to kinetochore;GO:0055015,biological_process ventricular cardiac muscle cell development;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060623,biological_process regulation of chromosome condensation;GO:0061575,molecular_function cyclin-dependent protein serine/threonine kinase activator activity;GO:0071283,biological_process cellular response to iron(III) ion;GO:0071398,biological_process cellular response to fatty acid;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071456,biological_process cellular response to hypoxia;GO:0090266,biological_process regulation of mitotic cell cycle spindle assembly checkpoint;GO:0097125,cellular_component cyclin B1-CDK1 complex;GO:1905448,biological_process positive regulation of mitochondrial ATP synthesis coupled electron transport;GO:2000775,biological_process histone H3-S10 phosphorylation involved in chromosome condensation	CCNB1; G2/mitotic-specific cyclin-B1; K05868	cyclin B1 [Source:HGNC Symbol%3BAcc:HGNC:1579]
ENSG00000099377	24.29	22.94	22.62	20.52	19.74	21.84	0.181467212716188	4.76977162848725	0.024500434304356	0.200081507249981	16:30985206-30989152:+	HSD3B7	14;GO:0003854,molecular_function 3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006694,biological_process steroid biosynthetic process;GO:0006699,biological_process bile acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0035754,biological_process B cell chemotaxis;GO:0047016,molecular_function cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process	HSD3B7; cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase [EC:1.1.1.181]; K12408	hydroxy-delta-5-steroid dehydrogenase%2C 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol%3BAcc:HGNC:18324]
ENSG00000147601	64.12	65.32	62.37	69.39	73.72	70.53	-0.14447631941329	6.4867256830343	0.0245253914693932	0.200153638599328	8:73008863-73048122:+	TERF1	44;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003720,molecular_function telomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007004,biological_process telomere maintenance via telomerase;GO:0007049,biological_process cell cycle;GO:0008156,biological_process negative regulation of DNA replication;GO:0008301,molecular_function DNA binding, bending;GO:0016233,biological_process telomere capping;GO:0016604,cellular_component nuclear body;GO:0031627,biological_process telomeric loop formation;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032214,biological_process negative regulation of telomere maintenance via semi-conservative replication;GO:0042162,molecular_function telomeric DNA binding;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043130,molecular_function ubiquitin binding;GO:0045141,biological_process meiotic telomere clustering;GO:0051301,biological_process cell division;GO:0051974,biological_process negative regulation of telomerase activity;GO:0061820,biological_process telomeric D-loop disassembly;GO:0070187,cellular_component telosome;GO:0071532,molecular_function ankyrin repeat binding;GO:0090656,biological_process t-circle formation;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1904792,biological_process positive regulation of telosome assembly;GO:1904850,biological_process negative regulation of establishment of protein localization to telomere;GO:1904911,biological_process negative regulation of establishment of RNA localization to telomere;GO:1904914,biological_process negative regulation of establishment of macromolecular complex localization to telomere;GO:1905778,biological_process negative regulation of exonuclease activity;GO:1905839,biological_process negative regulation of telomeric D-loop disassembly	NA	telomeric repeat binding factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11728]
ENSG00000184178	3.53	3.06	3.29	4.40	4.67	3.55	-0.331630223893692	2.98373432104367	0.0246112079730191	0.200722026655115	4:52872981-53366075:-	SCFD2	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0006810,biological_process transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0008150,biological_process biological_process;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport	NA	sec1 family domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30676]
ENSG00000158604	108.69	111.02	113.59	101.32	99.40	104.03	0.140509096712668	6.23165980562052	0.0247377495828099	0.201621592627327	7:44577893-44582287:-	TMED4	10;GO:0004871,molecular_function signal transducer activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0070062,cellular_component extracellular exosome	NA	transmembrane p24 trafficking protein 4 [Source:HGNC Symbol%3BAcc:HGNC:22301]
ENSG00000012171	13.33	11.20	14.35	15.36	14.12	15.92	-0.205046389315485	5.00261841275693	0.0247572001906853	0.201647720450772	3:50267557-50277546:+	SEMA3B	8;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0007267,biological_process cell-cell signaling;GO:0007411,biological_process axon guidance;GO:0038191,molecular_function neuropilin binding;GO:0050919,biological_process negative chemotaxis;GO:0070062,cellular_component extracellular exosome	SEMA3; semaphorin 3; K06840	semaphorin 3B [Source:HGNC Symbol%3BAcc:HGNC:10724]
ENSG00000171148	121.43	120.91	124.33	142.87	132.10	132.77	-0.141219786939735	7.38963934787608	0.0247973708483391	0.201842468419956	3:9779859-9793011:-	TADA3	30;GO:0000124,cellular_component SAGA complex;GO:0000278,biological_process mitotic cell cycle;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0010628,biological_process positive regulation of gene expression;GO:0016579,biological_process protein deubiquitination;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019904,molecular_function protein domain specific binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0030914,cellular_component STAGA complex;GO:0031063,biological_process regulation of histone deacetylation;GO:0031647,biological_process regulation of protein stability;GO:0033276,cellular_component transcription factor TFTC complex;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043966,biological_process histone H3 acetylation;GO:0043967,biological_process histone H4 acetylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0072686,cellular_component mitotic spindle;GO:0090043,biological_process regulation of tubulin deacetylation	NA	transcriptional adaptor 3 [Source:HGNC Symbol%3BAcc:HGNC:19422]
ENSG00000134333	1396.34	1447.30	1358.54	1577.91	1531.70	1525.63	-0.129815439429789	10.825163237154	0.0249514907348599	0.202645781367317	11:18394387-18408425:+	LDHA	33;GO:0001666,biological_process response to hypoxia;GO:0003824,molecular_function catalytic activity;GO:0004457,molecular_function lactate dehydrogenase activity;GO:0004459,molecular_function L-lactate dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006089,biological_process lactate metabolic process;GO:0006090,biological_process pyruvate metabolic process;GO:0006096,biological_process glycolytic process;GO:0007584,biological_process response to nutrient;GO:0009749,biological_process response to glucose;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019674,biological_process NAD metabolic process;GO:0019752,biological_process carboxylic acid metabolic process;GO:0019900,molecular_function kinase binding;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043627,biological_process response to estrogen;GO:0045296,molecular_function cadherin binding;GO:0048569,biological_process post-embryonic organ development;GO:0051287,molecular_function NAD binding;GO:0051591,biological_process response to cAMP;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]; K00016	lactate dehydrogenase A [Source:HGNC Symbol%3BAcc:HGNC:6535]
ENSG00000123975	558.45	653.64	545.95	649.84	696.66	649.48	-0.173261073804598	7.21374899181779	0.024954517165908	0.202645781367317	9:89311197-89316703:+	CKS2	18;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0007127,biological_process meiosis I;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008283,biological_process cell proliferation;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019901,molecular_function protein kinase binding;GO:0042393,molecular_function histone binding;GO:0043130,molecular_function ubiquitin binding;GO:0044772,biological_process mitotic cell cycle phase transition;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051301,biological_process cell division;GO:0061575,molecular_function cyclin-dependent protein serine/threonine kinase activator activity	NA	CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:2000]
ENSG00000118960	20.82	22.30	19.98	19.65	18.78	17.45	0.183897526207727	4.94361402494403	0.0249550998391711	0.202645781367317	2:20560447-20651089:-	HS1BP3	4;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042981,biological_process regulation of apoptotic process	NA	HCLS1 binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:24979]
ENSG00000161714	15.41	14.48	15.76	17.49	16.27	17.83	-0.162076561796133	5.32659356940472	0.0249613630637741	0.202645781367317	17:45108966-45133354:-	PLCD3	19;GO:0001525,biological_process angiogenesis;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0032154,cellular_component cleavage furrow;GO:0035556,biological_process intracellular signal transduction;GO:0042127,biological_process regulation of cell proliferation;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0060716,biological_process labyrinthine layer blood vessel development	PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]; K05857	phospholipase C delta 3 [Source:HGNC Symbol%3BAcc:HGNC:9061]
ENSG00000180815	2.56	2.88	2.58	2.96	3.25	3.44	-0.264393614559199	3.55795936056173	0.0250003823761675	0.202829899630959	X:19360055-19515261:-	MAP3K15	13;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	mitogen-activated protein kinase kinase kinase 15 [Source:HGNC Symbol%3BAcc:HGNC:31689]
ENSG00000114861	12.09	10.46	11.23	13.69	11.48	14.25	-0.207839736689574	4.98597969095056	0.0250468552672048	0.203074209295763	3:70954692-71583989:-	FOXP1	74;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002329,biological_process pre-B cell differentiation;GO:0002639,biological_process positive regulation of immunoglobulin production;GO:0002903,biological_process negative regulation of B cell apoptotic process;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007507,biological_process heart development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008045,biological_process motor neuron axon guidance;GO:0008134,molecular_function transcription factor binding;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0021517,biological_process ventral spinal cord development;GO:0021756,biological_process striatum development;GO:0030316,biological_process osteoclast differentiation;GO:0030324,biological_process lung development;GO:0030900,biological_process forebrain development;GO:0032496,biological_process response to lipopolysaccharide;GO:0032680,biological_process regulation of tumor necrosis factor production;GO:0033152,biological_process immunoglobulin V(D)J recombination;GO:0033574,biological_process response to testosterone;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035926,biological_process chemokine (C-C motif) ligand 2 secretion;GO:0036035,biological_process osteoclast development;GO:0042116,biological_process macrophage activation;GO:0042117,biological_process monocyte activation;GO:0042118,biological_process endothelial cell activation;GO:0042803,molecular_function protein homodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043621,molecular_function protein self-association;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045214,biological_process sarcomere organization;GO:0045655,biological_process regulation of monocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048745,biological_process smooth muscle tissue development;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050681,molecular_function androgen receptor binding;GO:0050706,biological_process regulation of interleukin-1 beta secretion;GO:0050727,biological_process regulation of inflammatory response;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060043,biological_process regulation of cardiac muscle cell proliferation;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0061052,biological_process negative regulation of cell growth involved in cardiac muscle cell development;GO:0061140,biological_process lung secretory cell differentiation;GO:0061470,biological_process T follicular helper cell differentiation;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0072358,biological_process cardiovascular system development;GO:0072619,biological_process interleukin-21 secretion;GO:1900424,biological_process regulation of defense response to bacterium;GO:1901249,biological_process regulation of lung goblet cell differentiation;GO:1901250,biological_process negative regulation of lung goblet cell differentiation;GO:1901256,biological_process regulation of macrophage colony-stimulating factor production;GO:1901509,biological_process regulation of endothelial tube morphogenesis;GO:1904637,biological_process cellular response to ionomycin;GO:1905206,biological_process positive regulation of hydrogen peroxide-induced cell death;GO:2000727,biological_process positive regulation of cardiac muscle cell differentiation;GO:2001182,biological_process regulation of interleukin-12 secretion	NA	forkhead box P1 [Source:HGNC Symbol%3BAcc:HGNC:3823]
ENSG00000145354	60.82	54.92	60.31	62.78	68.60	68.73	-0.168871206547919	5.18412208781984	0.0250908233390493	0.203297904769986	4:102868977-102889242:+	CISD2	18;GO:0000422,biological_process mitophagy;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006914,biological_process autophagy;GO:0010259,biological_process multicellular organism aging;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding	NA	CDGSH iron sulfur domain 2 [Source:HGNC Symbol%3BAcc:HGNC:24212]
ENSG00000156990	17.41	14.61	17.35	19.21	19.92	18.47	-0.201327885507764	4.55199932576539	0.0251257865804492	0.203448394535627	3:9837848-9844602:-	RPUSD3	8;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0019239,molecular_function deaminase activity;GO:0031119,biological_process tRNA pseudouridine synthesis	NA	RNA pseudouridylate synthase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28437]
ENSG00000112685	18.68	17.58	17.23	20.45	19.59	19.84	-0.149733648658067	5.71691875759996	0.0251489119739901	0.203469645927848	6:485132-693111:-	EXOC2	15;GO:0000145,cellular_component exocyst;GO:0001927,biological_process exocyst assembly;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017160,molecular_function Ral GTPase binding;GO:0019901,molecular_function protein kinase binding;GO:0030496,cellular_component midbody;GO:0047485,molecular_function protein N-terminus binding;GO:2000535,biological_process regulation of entry of bacterium into host cell	NA	exocyst complex component 2 [Source:HGNC Symbol%3BAcc:HGNC:24968]
ENSG00000104671	29.75	31.45	29.72	27.62	25.80	25.94	0.204657143836272	4.16740963347553	0.0251611944331948	0.203469645927848	8:30156296-30183640:+	DCTN6	11;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005869,cellular_component dynactin complex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II	DCTN6; dynactin 6; K10428	dynactin subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:16964]
ENSG00000129255	23.18	26.74	23.02	24.96	29.65	31.18	-0.228944357298001	4.69310730428329	0.0252226476460315	0.203833805488405	17:7583528-7592789:+	MPDU1	9;GO:0005515,molecular_function protein binding;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0006810,biological_process transport;GO:0009312,biological_process oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	mannose-P-dolichol utilization defect 1 [Source:HGNC Symbol%3BAcc:HGNC:7207]
ENSG00000151692	2.42	2.77	3.94	4.98	4.06	3.99	-0.494102192935909	1.85622257077002	0.0252451187487913	0.203841435698427	2:6917391-7068286:+	RNF144A	18;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 144A [Source:HGNC Symbol%3BAcc:HGNC:20457]
ENSG00000105617	8.03	8.45	8.08	9.74	10.34	10.39	-0.303273199437268	2.89373055788093	0.0252564350361863	0.203841435698427	19:54155160-54159882:-	LENG1	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	leukocyte receptor cluster member 1 [Source:HGNC Symbol%3BAcc:HGNC:15502]
ENSG00000112149	2.07	2.33	1.20	3.65	2.84	2.63	-0.709494598691502	0.730715934606482	0.0253451565119651	0.204354700987239	6:14117255-14136918:+	CD83	15;GO:0001817,biological_process regulation of cytokine production;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006952,biological_process defense response;GO:0006959,biological_process humoral immune response;GO:0007165,biological_process signal transduction;GO:0009897,cellular_component external side of plasma membrane;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032713,biological_process negative regulation of interleukin-4 production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0043372,biological_process positive regulation of CD4-positive, alpha-beta T cell differentiation	NA	CD83 molecule [Source:HGNC Symbol%3BAcc:HGNC:1703]
ENSG00000153485	29.67	25.63	29.76	23.92	23.93	24.97	0.243766993003434	3.75709157636282	0.0253592370625184	0.204354700987239	14:93184950-93187089:+	TMEM251	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 251 [Source:HGNC Symbol%3BAcc:HGNC:20218]
ENSG00000090889	41.10	41.34	36.74	42.56	48.82	43.45	-0.16669188271993	7.29190729685981	0.0253837031655317	0.204354700987239	X:70290089-70420832:+	KIF4A	29;GO:0000166,molecular_function nucleotide binding;GO:0000281,biological_process mitotic cytokinesis;GO:0003677,molecular_function DNA binding;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006996,biological_process organelle organization;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008089,biological_process anterograde axonal transport;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030496,cellular_component midbody;GO:0045171,cellular_component intercellular bridge;GO:0051256,biological_process mitotic spindle midzone assembly;GO:1904115,cellular_component axon cytoplasm	NA	kinesin family member 4A [Source:HGNC Symbol%3BAcc:HGNC:13339]
ENSG00000142694	19.97	15.44	20.22	15.28	12.10	16.76	0.353972336527514	3.07473935496255	0.0253858816500702	0.204354700987239	1:36322030-36324154:-	EVA1B	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	eva-1 homolog B [Source:HGNC Symbol%3BAcc:HGNC:25558]
ENSG00000061987	11.42	10.57	10.78	10.01	9.86	10.00	0.147439779076432	5.77188668523435	0.0254172896908247	0.204474929962545	12:62466816-62600479:+	MON2	6;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0015031,biological_process protein transport;GO:0070062,cellular_component extracellular exosome	NA	MON2 homolog%2C regulator of endosome-to-Golgi trafficking [Source:HGNC Symbol%3BAcc:HGNC:29177]
ENSG00000162063	9.34	8.63	8.80	9.22	12.04	10.36	-0.225702235323845	4.63150891362084	0.0255108281733372	0.20509450137023	16:2429393-2458854:+	CCNF	20;GO:0000209,biological_process protein polyubiquitination;GO:0000320,biological_process re-entry into mitotic cell cycle;GO:0001890,biological_process placenta development;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0010826,biological_process negative regulation of centrosome duplication;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030054,cellular_component cell junction;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	NA	cyclin F [Source:HGNC Symbol%3BAcc:HGNC:1591]
ENSG00000168259	67.62	67.98	69.36	78.11	72.23	77.76	-0.142654909635276	6.85199956394392	0.0255483422694863	0.20514664274033	17:41976432-42021376:-	DNAJC7	14;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0031072,molecular_function heat shock protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0070062,cellular_component extracellular exosome;GO:0070389,biological_process chaperone cofactor-dependent protein refolding;GO:1900034,biological_process regulation of cellular response to heat	NA	DnaJ heat shock protein family (Hsp40) member C7 [Source:HGNC Symbol%3BAcc:HGNC:12392]
ENSG00000189362	7.34	8.10	7.65	9.82	9.88	8.43	-0.276355295485598	3.43735061235127	0.0255657912240876	0.20514664274033	2:190504341-190534722:-	NEMP2	5;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear envelope integral membrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:33700]
ENSG00000196155	21.88	22.43	20.75	22.75	26.73	24.04	-0.165201914941757	6.41620936993309	0.0255757595020124	0.20514664274033	16:67277509-67289499:+	PLEKHG4	5;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0090630,biological_process activation of GTPase activity	NA	pleckstrin homology and RhoGEF domain containing G4 [Source:HGNC Symbol%3BAcc:HGNC:24501]
ENSG00000054654	9.53	10.06	9.89	8.21	9.87	8.31	0.170891870329931	7.67344792539381	0.0256074822477867	0.20514664274033	14:63852982-64226433:+	SYNE2	38;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005640,cellular_component nuclear outer membrane;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006998,biological_process nuclear envelope organization;GO:0007097,biological_process nuclear migration;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0010761,biological_process fibroblast migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016235,cellular_component aggresome;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0021817,biological_process nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0030016,cellular_component myofibril;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0031022,biological_process nuclear migration along microfilament;GO:0031258,cellular_component lamellipodium membrane;GO:0031527,cellular_component filopodium membrane;GO:0031965,cellular_component nuclear membrane;GO:0031981,cellular_component nuclear lumen;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034504,biological_process protein localization to nucleus;GO:0034993,cellular_component LINC complex;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051015,molecular_function actin filament binding;GO:0051642,biological_process centrosome localization;GO:0070062,cellular_component extracellular exosome;GO:0090286,biological_process cytoskeletal anchoring at nuclear membrane;GO:1902017,biological_process regulation of cilium assembly	NA	spectrin repeat containing nuclear envelope protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17084]
ENSG00000136630	7.72	7.90	7.79	7.16	6.27	6.24	0.261889636674115	3.41149977030199	0.0256121838048061	0.20514664274033	1:220879399-220885059:+	HLX	17;GO:0001889,biological_process liver development;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045627,biological_process positive regulation of T-helper 1 cell differentiation;GO:0045629,biological_process negative regulation of T-helper 2 cell differentiation;GO:0046622,biological_process positive regulation of organ growth;GO:0048484,biological_process enteric nervous system development;GO:0048513,biological_process animal organ development;GO:0048557,biological_process embryonic digestive tract morphogenesis	NA	H2.0 like homeobox [Source:HGNC Symbol%3BAcc:HGNC:4978]
ENSG00000164849	5.87	4.02	5.97	3.37	4.71	3.66	0.463827572770253	2.25463979855288	0.025616474361356	0.20514664274033	7:1044575-1059261:+	GPR146	7;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 146 [Source:HGNC Symbol%3BAcc:HGNC:21718]
ENSG00000145545	43.10	45.57	42.35	49.77	48.66	48.62	-0.157997687502764	5.32621886479208	0.0256627478952973	0.205384712846115	5:6633342-6674386:+	SRD5A1	61;GO:0001655,biological_process urogenital system development;GO:0001889,biological_process liver development;GO:0003865,molecular_function 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006702,biological_process androgen biosynthetic process;GO:0007530,biological_process sex determination;GO:0007548,biological_process sex differentiation;GO:0008202,biological_process steroid metabolic process;GO:0008209,biological_process androgen metabolic process;GO:0008584,biological_process male gonad development;GO:0009055,molecular_function electron carrier activity;GO:0009267,biological_process cellular response to starvation;GO:0014070,biological_process response to organic cyclic compound;GO:0014850,biological_process response to muscle activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016101,biological_process diterpenoid metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0021510,biological_process spinal cord development;GO:0021766,biological_process hippocampus development;GO:0021794,biological_process thalamus development;GO:0021854,biological_process hypothalamus development;GO:0021983,biological_process pituitary gland development;GO:0021987,biological_process cerebral cortex development;GO:0030154,biological_process cell differentiation;GO:0030539,biological_process male genitalia development;GO:0030540,biological_process female genitalia development;GO:0031090,cellular_component organelle membrane;GO:0032354,biological_process response to follicle-stimulating hormone;GO:0032355,biological_process response to estradiol;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033218,molecular_function amide binding;GO:0033574,biological_process response to testosterone;GO:0042428,biological_process serotonin metabolic process;GO:0042448,biological_process progesterone metabolic process;GO:0042493,biological_process response to drug;GO:0042747,biological_process circadian sleep/wake cycle, REM sleep;GO:0043025,cellular_component neuronal cell body;GO:0043209,cellular_component myelin sheath;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043627,biological_process response to estrogen;GO:0047751,molecular_function cholestenone 5-alpha-reductase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055114,biological_process oxidation-reduction process;GO:0060348,biological_process bone development;GO:0060416,biological_process response to growth hormone;GO:0060992,biological_process response to fungicide;GO:0070402,molecular_function NADPH binding;GO:0070852,cellular_component cell body fiber;GO:0071320,biological_process cellular response to cAMP;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071394,biological_process cellular response to testosterone stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0071872,biological_process cellular response to epinephrine stimulus	SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]; K12343	steroid 5 alpha-reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:11284]
ENSG00000198890	16.82	17.33	16.16	13.44	13.89	16.13	0.218210706087937	4.14680187052909	0.025680686743467	0.20539585344501	1:107056678-107059294:+	PRMT6	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006479,biological_process protein methylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008168,molecular_function methyltransferase activity;GO:0008469,molecular_function histone-arginine N-methyltransferase activity;GO:0016032,biological_process viral process;GO:0016049,biological_process cell growth;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0019919,biological_process peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0032259,biological_process methylation;GO:0034970,biological_process histone H3-R2 methylation;GO:0035241,molecular_function protein-arginine omega-N monomethyltransferase activity;GO:0035242,molecular_function protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054,molecular_function histone methyltransferase activity;GO:0042393,molecular_function histone binding;GO:0043985,biological_process histone H4-R3 methylation;GO:0044020,molecular_function histone methyltransferase activity (H4-R3 specific);GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070611,molecular_function histone methyltransferase activity (H3-R2 specific);GO:0070612,molecular_function histone methyltransferase activity (H2A-R3 specific);GO:0090398,biological_process cellular senescence	NA	protein arginine methyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:18241]
ENSG00000243927	95.86	101.43	104.42	94.04	82.11	92.82	0.175676771384796	5.16226418226888	0.0257302846576669	0.205660027981725	21:34073223-34143034:+	MRPS6	14;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015935,cellular_component small ribosomal subunit;GO:0019843,molecular_function rRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination;GO:0070181,molecular_function small ribosomal subunit rRNA binding	RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6; K02990	mitochondrial ribosomal protein S6 [Source:HGNC Symbol%3BAcc:HGNC:14051]
ENSG00000163735	26.64	25.15	32.07	35.25	30.82	37.83	-0.292171128985967	3.44892139296451	0.0258079090978085	0.206147732066343	4:73995641-73998779:-	CXCL5	20;GO:0002446,biological_process neutrophil mediated immunity;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0008009,molecular_function chemokine activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0032496,biological_process response to lipopolysaccharide;GO:0042802,molecular_function identical protein binding;GO:0045236,molecular_function CXCR chemokine receptor binding;GO:0060326,biological_process cell chemotaxis;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0090023,biological_process positive regulation of neutrophil chemotaxis	CXCL5_6, SCYB5_6; C-X-C motif chemokine 5/6; K05506	C-X-C motif chemokine ligand 5 [Source:HGNC Symbol%3BAcc:HGNC:10642]
ENSG00000103351	27.68	22.54	25.18	28.96	27.56	30.08	-0.182073528605947	5.21483259184632	0.0258422197429719	0.206289050591325	16:3500923-3539048:+	CLUAP1	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip	NA	clusterin associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19009]
ENSG00000188177	5.68	5.94	5.75	7.07	5.95	7.29	-0.216644462869728	4.4988309082691	0.0259473622519349	0.206995249121637	2:112275593-112340063:+	ZC3H6	4;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:24762]
ENSG00000065029	22.44	24.59	23.10	21.49	21.31	20.37	0.159471856095464	5.34044579524498	0.0259967406163835	0.207255967418862	6:35258908-35295985:+	ZNF76	12;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 76 [Source:HGNC Symbol%3BAcc:HGNC:13149]
ENSG00000070047	11.89	13.89	12.71	11.12	12.46	10.63	0.178712210226505	5.90734833586283	0.0260319302191122	0.207403305397843	11:576485-612222:+	PHRF1	6;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0046872,molecular_function metal ion binding;GO:0070063,molecular_function RNA polymerase binding	NA	PHD and ring finger domains 1 [Source:HGNC Symbol%3BAcc:HGNC:24351]
ENSG00000109065	26.78	27.32	27.82	23.02	23.86	25.49	0.189098798138054	4.4356741665728	0.026065740798871	0.207539474365866	17:74770546-74776367:-	NAT9	5;GO:0005515,molecular_function protein binding;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0043234,cellular_component protein complex	NA	N-acetyltransferase 9 (putative) [Source:HGNC Symbol%3BAcc:HGNC:23133]
ENSG00000161513	5.47	6.30	5.66	7.16	6.92	6.80	-0.256400955718503	3.55718282187328	0.0260938865480016	0.207630393410477	17:74862496-74873031:-	FDXR	18;GO:0004324,molecular_function ferredoxin-NADP+ reductase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0015039,molecular_function NADPH-adrenodoxin reductase activity;GO:0016125,biological_process sterol metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070402,molecular_function NADPH binding;GO:0070995,biological_process NADPH oxidation	NA	ferredoxin reductase [Source:HGNC Symbol%3BAcc:HGNC:3642]
ENSG00000111816	4.80	5.61	5.25	3.66	4.81	4.08	0.32493440785487	2.85456500488915	0.0261941123465925	0.20829437319555	6:115931148-116060758:-	FRK	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0035578,cellular_component azurophil granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome	FRK, PTK5; fyn-related kinase [EC:2.7.10.2]; K08892	fyn related Src family tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:3955]
ENSG00000116209	183.64	175.69	176.42	154.34	167.24	168.82	0.139662168163991	7.50159182377034	0.026226378746101	0.208417438780635	1:54026680-54053504:-	TMEM59	22;GO:0000137,cellular_component Golgi cis cisterna;GO:0000138,cellular_component Golgi trans cisterna;GO:0000139,cellular_component Golgi membrane;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005797,cellular_component Golgi medial cisterna;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006914,biological_process autophagy;GO:0010508,biological_process positive regulation of autophagy;GO:0010955,biological_process negative regulation of protein processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane;GO:0070062,cellular_component extracellular exosome;GO:0090005,biological_process negative regulation of establishment of protein localization to plasma membrane;GO:0090285,biological_process negative regulation of protein glycosylation in Golgi	NA	transmembrane protein 59 [Source:HGNC Symbol%3BAcc:HGNC:1239]
ENSG00000008086	5.50	4.63	5.10	4.38	3.92	4.75	0.239931510549403	4.02106404394893	0.0262545775948767	0.208508043304673	X:18425582-18653629:+	CDKL5	24;GO:0000166,molecular_function nucleotide binding;GO:0001764,biological_process neuron migration;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032587,cellular_component ruffle membrane;GO:0032839,cellular_component dendrite cytoplasm;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044294,cellular_component dendritic growth cone;GO:0045202,cellular_component synapse;GO:0045773,biological_process positive regulation of axon extension;GO:0046777,biological_process protein autophosphorylation;GO:0048365,molecular_function Rac GTPase binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050773,biological_process regulation of dendrite development;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0060999,biological_process positive regulation of dendritic spine development	NA	cyclin dependent kinase like 5 [Source:HGNC Symbol%3BAcc:HGNC:11411]
ENSG00000259330	5.08	3.96	4.65	3.26	3.14	2.60	0.630448037590363	0.916526943005806	0.0263670952087225	0.209267744773576	15:40323663-40326715:+	INAFM2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	InaF motif containing 2 [Source:HGNC Symbol%3BAcc:HGNC:35165]
ENSG00000076067	9.53	12.48	10.14	12.45	14.89	11.85	-0.282640996018597	4.06747343355885	0.0263860093432564	0.209284047270187	12:56521928-56596196:+	RBMS2	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006396,biological_process RNA processing	NA	RNA binding motif single stranded interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9909]
ENSG00000130733	32.08	35.93	35.61	30.72	30.39	31.60	0.168164387427037	5.10467450051325	0.0264291903616377	0.209492681966162	19:10922184-10928681:-	YIPF2	6;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030133,cellular_component transport vesicle	NA	Yip1 domain family member 2 [Source:HGNC Symbol%3BAcc:HGNC:28476]
ENSG00000198846	15.98	14.47	16.70	14.04	12.69	14.62	0.20522264387557	4.55253265588355	0.0264513049029356	0.209534172150696	8:58805417-59119208:-	TOX	2;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	thymocyte selection associated high mobility group box [Source:HGNC Symbol%3BAcc:HGNC:18988]
ENSG00000172650	4.21	4.03	4.60	3.55	3.60	3.48	0.289226934858227	3.03980102317046	0.0266538342486626	0.211003854928986	10:73674284-73698159:-	AGAP5	3;GO:0005096,molecular_function GTPase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	NA	ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 5 [Source:HGNC Symbol%3BAcc:HGNC:23467]
ENSG00000069956	30.79	29.12	29.67	25.79	27.60	28.32	0.145604756906707	5.95275544044597	0.0267479220889273	0.211613739254209	15:51952105-52067372:+	MAPK6	24;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0032156,cellular_component septin cytoskeleton;GO:0043234,cellular_component protein complex;GO:0046982,molecular_function protein heterodimerization activity;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0071310,biological_process cellular response to organic substance	MAPK4_6; mitogen-activated protein kinase 4/6 [EC:2.7.11.24]; K06855	mitogen-activated protein kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:6879]
ENSG00000099282	10.04	9.03	9.90	7.65	5.90	9.30	0.353743511563925	2.98888883026644	0.0267706215990507	0.211658424145871	10:69451472-69507669:+	TSPAN15	14;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0031902,cellular_component late endosome membrane;GO:0051604,biological_process protein maturation;GO:0070062,cellular_component extracellular exosome;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0097197,cellular_component tetraspanin-enriched microdomain	NA	tetraspanin 15 [Source:HGNC Symbol%3BAcc:HGNC:23298]
ENSG00000179889	52.56	53.96	52.14	50.19	48.25	46.75	0.139241343428166	7.08924614527515	0.0268314300121132	0.211823356185547	16:14974590-15139339:+	PDXDC1	8;GO:0003824,molecular_function catalytic activity;GO:0005794,cellular_component Golgi apparatus;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding	NA	pyridoxal dependent decarboxylase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28995]
ENSG00000151849	3.34	3.08	3.61	2.73	3.10	2.67	0.25729604046707	3.7018209688931	0.0268338643645932	0.211823356185547	13:24882283-24922889:-	CENPJ	24;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007020,biological_process microtubule nucleation;GO:0007099,biological_process centriole replication;GO:0008275,cellular_component gamma-tubulin small complex;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015631,molecular_function tubulin binding;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0046599,biological_process regulation of centriole replication;GO:0046785,biological_process microtubule polymerization;GO:0051301,biological_process cell division;GO:0061511,biological_process centriole elongation;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centromere protein J [Source:HGNC Symbol%3BAcc:HGNC:17272]
ENSG00000158545	21.68	20.67	20.67	22.50	23.23	24.52	-0.144429946626746	6.03674214897198	0.0268426761685222	0.211823356185547	16:88570380-88631966:+	ZC3H18	6;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016607,cellular_component nuclear speck;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 18 [Source:HGNC Symbol%3BAcc:HGNC:25091]
ENSG00000132716	9.37	10.28	10.16	9.01	8.87	8.12	0.206787459520853	4.25118596445947	0.0268934812291722	0.212089442501724	1:160215714-160262531:-	DCAF8	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 8 [Source:HGNC Symbol%3BAcc:HGNC:24891]
ENSG00000170390	1.63	1.97	3.03	1.57	1.56	1.57	0.510848922988921	2.21374550146659	0.0269131521166454	0.212109814110425	4:150078273-150257457:+	DCLK2	21;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006468,biological_process protein phosphorylation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0021766,biological_process hippocampus development;GO:0021860,biological_process pyramidal neuron development;GO:0030182,biological_process neuron differentiation;GO:0035556,biological_process intracellular signal transduction;GO:1900181,biological_process negative regulation of protein localization to nucleus	NA	doublecortin like kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:19002]
ENSG00000132740	6.08	5.23	6.34	5.25	5.01	5.02	0.228393715286166	4.0559697067478	0.0269450456321307	0.212226428573375	11:68903841-68940602:+	IGHMBP2	34;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006412,biological_process translation;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008134,molecular_function transcription factor binding;GO:0008186,molecular_function RNA-dependent ATPase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032508,biological_process DNA duplex unwinding;GO:0032575,molecular_function ATP-dependent 5'-3' RNA helicase activity;GO:0042995,cellular_component cell projection;GO:0043022,molecular_function ribosome binding;GO:0043141,molecular_function ATP-dependent 5'-3' DNA helicase activity;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization	NA	immunoglobulin mu binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:5542]
ENSG00000067141	12.65	13.10	12.82	11.75	12.44	10.41	0.168459536044339	5.76325007247264	0.026980426885675	0.212370348086166	15:73051709-73305206:+	NEO1	15;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0039706,molecular_function co-receptor binding;GO:0055072,biological_process iron ion homeostasis;GO:0098797,cellular_component plasma membrane protein complex	NEO1; neogenin; K06766	neogenin 1 [Source:HGNC Symbol%3BAcc:HGNC:7754]
ENSG00000111424	0.79	0.67	0.57	1.31	0.90	1.18	-0.724681173550622	0.54201622008349	0.0270477053056663	0.212757082207106	12:47841536-47943048:-	VDR	45;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000902,biological_process cell morphogenesis;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007595,biological_process lactation;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008434,molecular_function calcitriol receptor activity;GO:0009887,biological_process organ morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0010980,biological_process positive regulation of vitamin D 24-hydroxylase activity;GO:0038183,biological_process bile acid signaling pathway;GO:0038186,molecular_function lithocholic acid receptor activity;GO:0043235,cellular_component receptor complex;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046697,biological_process decidualization;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0050892,biological_process intestinal absorption;GO:0060058,biological_process positive regulation of apoptotic process involved in mammary gland involution;GO:0060558,biological_process regulation of calcidiol 1-monooxygenase activity;GO:0060745,biological_process mammary gland branching involved in pregnancy;GO:0070561,biological_process vitamin D receptor signaling pathway;GO:0070644,molecular_function vitamin D response element binding;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1902098,molecular_function calcitriol binding;GO:1902121,molecular_function lithocholic acid binding	VDR, NR1I1; vitamin D3 receptor; K08539	vitamin D receptor [Source:HGNC Symbol%3BAcc:HGNC:12679]
ENSG00000143537	53.25	52.28	51.55	48.39	47.29	48.68	0.133576880475927	7.09679996713701	0.0270826002857564	0.212757082207106	1:155050565-155062775:+	ADAM15	37;GO:0001525,biological_process angiogenesis;GO:0001669,cellular_component acrosomal vesicle;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0006508,biological_process proteolysis;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008584,biological_process male gonad development;GO:0009986,cellular_component cell surface;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0030308,biological_process negative regulation of cell growth;GO:0030336,biological_process negative regulation of cell migration;GO:0030574,biological_process collagen catabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042246,biological_process tissue regeneration;GO:0042995,cellular_component cell projection;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0070062,cellular_component extracellular exosome;GO:0070528,biological_process protein kinase C signaling;GO:1900121,biological_process negative regulation of receptor binding	NA	ADAM metallopeptidase domain 15 [Source:HGNC Symbol%3BAcc:HGNC:193]
ENSG00000129103	232.67	217.98	244.94	211.73	211.56	213.96	0.138756922864842	8.28889878700271	0.0271193466819134	0.212757082207106	7:56064001-56080670:+	SUMF2	5;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	sulfatase modifying factor 2 [Source:HGNC Symbol%3BAcc:HGNC:20415]
ENSG00000206527	28.47	27.02	28.32	36.75	30.18	31.11	-0.211738007225279	4.54615215335667	0.0271220634011579	0.212757082207106	3:123490819-123585185:-	HACD2	20;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0018812,molecular_function 3-hydroxyacyl-CoA dehydratase activity;GO:0019899,molecular_function enzyme binding;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030497,biological_process fatty acid elongation;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0080023,molecular_function 3R-hydroxyacyl-CoA dehydratase activity;GO:0102343,molecular_function 3-hydroxy-arachidoyl-CoA dehydratase activity;GO:0102344,molecular_function 3-hydroxy-behenoyl-CoA dehydratase activity;GO:0102345,molecular_function 3-hydroxy-lignoceroyl-CoA dehydratase activity	HACD, PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]; K10703	3-hydroxyacyl-CoA dehydratase 2 [Source:HGNC Symbol%3BAcc:HGNC:9640]
ENSG00000055955	12.51	8.65	12.70	10.44	7.60	9.65	0.307538769870885	4.86135137478367	0.0271221417746712	0.212757082207106	3:52812974-52831479:-	ITIH4	16;GO:0002576,biological_process platelet degranulation;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006953,biological_process acute-phase response;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030212,biological_process hyaluronan metabolic process;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031089,cellular_component platelet dense granule lumen;GO:0034097,biological_process response to cytokine;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	NA	inter-alpha-trypsin inhibitor heavy chain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:6169]
ENSG00000109610	60.91	68.62	54.59	44.92	59.83	53.03	0.231213782295861	5.36024986415126	0.027156216183813	0.212757082207106	4:24789911-24800842:+	SOD3	23;GO:0001666,biological_process response to hypoxia;GO:0004784,molecular_function superoxide dismutase activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005796,cellular_component Golgi lumen;GO:0006801,biological_process superoxide metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0008201,molecular_function heparin binding;GO:0008270,molecular_function zinc ion binding;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019430,biological_process removal of superoxide radicals;GO:0031012,cellular_component extracellular matrix;GO:0034599,biological_process cellular response to oxidative stress;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	NA	superoxide dismutase 3 [Source:HGNC Symbol%3BAcc:HGNC:11181]
ENSG00000196497	13.90	14.41	13.55	14.81	15.92	16.15	-0.153756718179709	5.6130677533481	0.0271649783105046	0.212757082207106	14:24180218-24188964:-	IPO4	21;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000790,cellular_component nuclear chromatin;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0043234,cellular_component protein complex	NA	importin 4 [Source:HGNC Symbol%3BAcc:HGNC:19426]
ENSG00000151327	35.57	41.01	39.27	33.06	35.22	35.05	0.172170408204084	5.14659395084233	0.0271891720108773	0.212757082207106	14:35044906-35113130:+	FAM177A1	NA	NA	family with sequence similarity 177 member A1 [Source:HGNC Symbol%3BAcc:HGNC:19829]
ENSG00000176105	59.67	58.07	64.65	66.81	65.23	72.59	-0.15328351370338	6.73240127813715	0.0271977752200738	0.212757082207106	18:721587-812546:-	YES1	46;GO:0000166,molecular_function nucleotide binding;GO:0001784,molecular_function phosphotyrosine binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005102,molecular_function receptor binding;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031295,biological_process T cell costimulation;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042127,biological_process regulation of cell proliferation;GO:0043114,biological_process regulation of vascular permeability;GO:0044325,molecular_function ion channel binding;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0071300,biological_process cellular response to retinoic acid;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus	YES1; tyrosine-protein kinase Yes [EC:2.7.10.2]; K05705	YES proto-oncogene 1%2C Src family tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:12841]
ENSG00000153786	82.64	79.22	81.00	95.13	90.86	85.40	-0.147444798842917	6.47496243247	0.0272009578234655	0.212757082207106	16:84974180-85011535:-	ZDHHC7	10;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018230,biological_process peptidyl-L-cysteine S-palmitoylation;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 7 [Source:HGNC Symbol%3BAcc:HGNC:18459]
ENSG00000047634	16.41	19.31	18.14	14.07	15.86	16.27	0.225595470719887	4.05369627410808	0.0272765457345943	0.213213956047556	X:17737448-17754988:+	SCML1	6;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009653,biological_process anatomical structure morphogenesis	NA	sex comb on midleg like 1 (Drosophila) [Source:HGNC Symbol%3BAcc:HGNC:10580]
ENSG00000102100	14.74	13.49	15.49	12.10	13.36	13.06	0.199499308071308	4.51771057160232	0.027332642906309	0.213411367219515	X:48903179-48911958:-	SLC35A2	14;GO:0000139,cellular_component Golgi membrane;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005459,molecular_function UDP-galactose transmembrane transporter activity;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006012,biological_process galactose metabolic process;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015785,biological_process UDP-galactose transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0072334,biological_process UDP-galactose transmembrane transport	NA	solute carrier family 35 member A2 [Source:HGNC Symbol%3BAcc:HGNC:11022]
ENSG00000151923	74.60	72.49	85.26	70.54	65.69	72.49	0.167593158553382	6.54056872895165	0.0273476205909596	0.213411367219515	10:119571801-119597029:-	TIAL1	18;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0006952,biological_process defense response;GO:0007281,biological_process germ cell development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010494,cellular_component cytoplasmic stress granule;GO:0017091,molecular_function AU-rich element binding;GO:0017145,biological_process stem cell division;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070062,cellular_component extracellular exosome	NA	TIA1 cytotoxic granule associated RNA binding protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:11804]
ENSG00000155324	10.05	9.20	8.99	7.12	8.89	8.02	0.247315764266081	3.84271392841589	0.0273533783328969	0.213411367219515	5:126360131-126496494:+	GRAMD2B	5;GO:0005515,molecular_function protein binding;GO:0005881,cellular_component cytoplasmic microtubule;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042802,molecular_function identical protein binding	NA	GRAM domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:24911]
ENSG00000077585	21.39	23.22	20.45	20.56	18.11	18.37	0.196907612089827	4.61787495441618	0.0274809457338868	0.21420386070033	1:236142504-236221865:+	GPR137B	5;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 137B [Source:HGNC Symbol%3BAcc:HGNC:11862]
ENSG00000058729	8.81	7.90	8.33	7.33	7.15	7.25	0.221353024124657	3.90423640107111	0.0274894666958533	0.21420386070033	5:97160866-97183260:-	RIOK2	19;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030688,cellular_component preribosome, small subunit precursor;GO:0042254,biological_process ribosome biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0046872,molecular_function metal ion binding;GO:2000208,biological_process positive regulation of ribosomal small subunit export from nucleus;GO:2000234,biological_process positive regulation of rRNA processing	RIOK2; RIO kinase 2 [EC:2.7.11.1]; K07179	RIO kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:18999]
ENSG00000181856	2.23	2.03	1.61	1.36	1.43	1.41	0.491209810849257	1.53719367389225	0.0275261259935529	0.214213418242714	17:7281666-7288257:+	SLC2A4	46;GO:0005215,molecular_function transporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005771,cellular_component multivesicular body;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005975,biological_process carbohydrate metabolic process;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010021,biological_process amylopectin biosynthetic process;GO:0012505,cellular_component endomembrane system;GO:0012506,cellular_component vesicle membrane;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030315,cellular_component T-tubule;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031982,cellular_component vesicle;GO:0032593,cellular_component insulin-responsive compartment;GO:0032869,biological_process cellular response to insulin stimulus;GO:0042383,cellular_component sarcolemma;GO:0042593,biological_process glucose homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044381,biological_process glucose import in response to insulin stimulus;GO:0045121,cellular_component membrane raft;GO:0045471,biological_process response to ethanol;GO:0046323,biological_process glucose import;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050873,biological_process brown fat cell differentiation;GO:0055056,molecular_function D-glucose transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071456,biological_process cellular response to hypoxia;GO:0071470,biological_process cellular response to osmotic stress;GO:1904659,biological_process glucose transmembrane transport	SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4; K07191	solute carrier family 2 member 4 [Source:HGNC Symbol%3BAcc:HGNC:11009]
ENSG00000106462	28.48	32.30	27.31	32.85	36.53	31.11	-0.180962757410553	6.2693875913863	0.0275269678390619	0.214213418242714	7:148807382-148884321:-	EZH2	69;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000975,molecular_function regulatory region DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006306,biological_process DNA methylation;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008168,molecular_function methyltransferase activity;GO:0010468,biological_process regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0014013,biological_process regulation of gliogenesis;GO:0014834,biological_process skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0021695,biological_process cerebellar cortex development;GO:0021766,biological_process hippocampus development;GO:0031490,molecular_function chromatin DNA binding;GO:0032259,biological_process methylation;GO:0032355,biological_process response to estradiol;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0034968,biological_process histone lysine methylation;GO:0035098,cellular_component ESC/E(Z) complex;GO:0035984,biological_process cellular response to trichostatin A;GO:0036333,biological_process hepatocyte homeostasis;GO:0042054,molecular_function histone methyltransferase activity;GO:0042127,biological_process regulation of cell proliferation;GO:0042752,biological_process regulation of circadian rhythm;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045120,cellular_component pronucleus;GO:0045605,biological_process negative regulation of epidermal cell differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046976,molecular_function histone methyltransferase activity (H3-K27 specific);GO:0048387,biological_process negative regulation of retinoic acid receptor signaling pathway;GO:0048511,biological_process rhythmic process;GO:0050767,biological_process regulation of neurogenesis;GO:0051154,biological_process negative regulation of striated muscle cell differentiation;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070314,biological_process G1 to G0 transition;GO:0070734,biological_process histone H3-K27 methylation;GO:0070878,molecular_function primary miRNA binding;GO:0071168,biological_process protein localization to chromatin;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0097421,biological_process liver regeneration;GO:0098532,biological_process histone H3-K27 trimethylation;GO:1900006,biological_process positive regulation of dendrite development;GO:1904772,biological_process response to tetrachloromethane;GO:1990841,molecular_function promoter-specific chromatin binding;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	EZH2; [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]; K11430	enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:3527]
ENSG00000121716	34.81	36.69	36.84	31.18	35.28	30.09	0.17775226166581	5.16478247522348	0.0275424647962114	0.214213418242714	7:100352175-100367733:+	PILRB	9;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007171,biological_process activation of transmembrane receptor protein tyrosine kinase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042288,molecular_function MHC class I protein binding;GO:0050776,biological_process regulation of immune response	NA	paired immunoglobin-like type 2 receptor beta [Source:HGNC Symbol%3BAcc:HGNC:18297]
ENSG00000156531	14.74	17.71	17.63	18.69	22.92	18.25	-0.24852072117678	4.4658149536147	0.0275630147279091	0.214239011783053	X:134373252-134428791:+	PHF6	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0015631,molecular_function tubulin binding;GO:0019899,molecular_function enzyme binding;GO:0042393,molecular_function histone binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:0051219,molecular_function phosphoprotein binding;GO:0097110,molecular_function scaffold protein binding	NA	PHD finger protein 6 [Source:HGNC Symbol%3BAcc:HGNC:18145]
ENSG00000198353	12.40	11.70	13.01	10.78	10.63	9.68	0.273692770141656	3.19379116880247	0.0275931629360105	0.214241330519509	12:54016930-54056030:+	HOXC4	17;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048562,biological_process embryonic organ morphogenesis;GO:0051216,biological_process cartilage development;GO:0071837,molecular_function HMG box domain binding	NA	homeobox C4 [Source:HGNC Symbol%3BAcc:HGNC:5126]
ENSG00000169684	5.43	4.49	4.14	6.13	6.16	5.51	-0.320121567861151	2.93410121304206	0.0275978319101502	0.214241330519509	15:78565519-78595269:+	CHRNA5	25;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005892,cellular_component acetylcholine-gated channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0007268,biological_process chemical synaptic transmission;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015464,molecular_function acetylcholine receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022848,molecular_function acetylcholine-gated cation channel activity;GO:0030054,cellular_component cell junction;GO:0034220,biological_process ion transmembrane transport;GO:0035094,biological_process response to nicotine;GO:0035095,biological_process behavioral response to nicotine;GO:0042166,molecular_function acetylcholine binding;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060079,biological_process excitatory postsynaptic potential	CHRNA5; nicotinic acetylcholine receptor alpha-5; K04807	cholinergic receptor nicotinic alpha 5 subunit [Source:HGNC Symbol%3BAcc:HGNC:1959]
ENSG00000100065	64.84	54.34	62.37	71.05	63.84	70.63	-0.16596571631219	7.69095350518371	0.0276804455916444	0.214748356955676	22:37490361-37519542:-	CARD10	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006461,biological_process protein complex assembly;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0032449,cellular_component CBM complex;GO:0042981,biological_process regulation of apoptotic process	NA	caspase recruitment domain family member 10 [Source:HGNC Symbol%3BAcc:HGNC:16422]
ENSG00000170190	2.54	3.95	3.56	4.47	5.51	3.66	-0.436251741878298	2.76785392519202	0.0277115205208638	0.214855155668633	17:75087726-75106162:+	SLC16A5	9;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 16 member 5 [Source:HGNC Symbol%3BAcc:HGNC:10926]
ENSG00000112208	31.13	33.21	27.44	33.47	37.62	35.88	-0.215114461813509	4.40064109568798	0.027817472061063	0.215541997936314	6:57172325-57189833:+	BAG2	9;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0019538,biological_process protein metabolic process;GO:0042802,molecular_function identical protein binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051087,molecular_function chaperone binding;GO:1900034,biological_process regulation of cellular response to heat	BAG2; BCL2-associated athanogene 2; K09556	BCL2 associated athanogene 2 [Source:HGNC Symbol%3BAcc:HGNC:938]
ENSG00000051128	45.00	45.44	42.34	38.51	43.84	35.52	0.183619176138972	5.50322599938432	0.0278461616283041	0.21562969700071	19:18929200-18941261:-	HOMER3	16;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006605,biological_process protein targeting;GO:0007216,biological_process G-protein coupled glutamate receptor signaling pathway;GO:0008022,molecular_function protein C-terminus binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0035256,molecular_function G-protein coupled glutamate receptor binding;GO:0045178,cellular_component basal part of cell;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	HOMER; homer; K15010	homer scaffolding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:17514]
ENSG00000256453	15.01	15.43	15.57	14.56	12.60	12.48	0.225951693531415	3.93046022925461	0.027918118281751	0.216038530361685	5:140670793-140673586:-	DND1	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007281,biological_process germ cell development;GO:0017091,molecular_function AU-rich element binding;GO:0060965,biological_process negative regulation of gene silencing by miRNA	NA	DND microRNA-mediated repression inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:23799]
ENSG00000102572	56.37	46.35	52.57	64.81	53.23	60.53	-0.187405865450785	6.35587115597471	0.0279337663119717	0.216038530361685	13:98445184-98577940:-	STK24	35;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0009267,biological_process cellular response to starvation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030336,biological_process negative regulation of cell migration;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0042542,biological_process response to hydrogen peroxide;GO:0042981,biological_process regulation of apoptotic process;GO:0045296,molecular_function cadherin binding;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048679,biological_process regulation of axon regeneration;GO:0048812,biological_process neuron projection morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097194,biological_process execution phase of apoptosis	NA	serine/threonine kinase 24 [Source:HGNC Symbol%3BAcc:HGNC:11403]
ENSG00000116874	13.54	14.17	14.97	17.19	17.97	15.13	-0.223484372012124	4.11370981122105	0.0280652955719303	0.21689349165665	1:119031215-119140671:-	WARS2	13;GO:0000166,molecular_function nucleotide binding;GO:0001570,biological_process vasculogenesis;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004830,molecular_function tryptophan-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006436,biological_process tryptophanyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity	WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]; K01867	tryptophanyl tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:12730]
ENSG00000154330	0.75	0.28	0.39	0.88	0.67	0.95	-0.753907699236799	0.368160877073054	0.0280792589295285	0.21689349165665	9:68328307-68531061:+	PGM5	22;GO:0000287,molecular_function magnesium ion binding;GO:0001725,cellular_component stress fiber;GO:0005198,molecular_function structural molecule activity;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005914,cellular_component spot adherens junction;GO:0005925,cellular_component focal adhesion;GO:0005975,biological_process carbohydrate metabolic process;GO:0007155,biological_process cell adhesion;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0014704,cellular_component intercalated disc;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030055,cellular_component cell-substrate junction;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0046872,molecular_function metal ion binding;GO:0071704,biological_process organic substance metabolic process	NA	phosphoglucomutase 5 [Source:HGNC Symbol%3BAcc:HGNC:8908]
ENSG00000048544	80.82	80.19	81.53	91.63	87.92	90.38	-0.142267021268942	5.69258934165244	0.028146383800446	0.217188575640663	6:42206800-42217865:-	MRPS10	9;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0008150,biological_process biological_process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10; K02946	mitochondrial ribosomal protein S10 [Source:HGNC Symbol%3BAcc:HGNC:14502]
ENSG00000073417	17.65	17.13	18.36	16.40	16.38	15.40	0.155851204224219	5.45576423254866	0.028152454540065	0.217188575640663	15:84980439-85139145:+	PDE8A	17;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0005829,cellular_component cytosol;GO:0006198,biological_process cAMP catabolic process;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0009187,biological_process cyclic nucleotide metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019900,molecular_function kinase binding;GO:0046872,molecular_function metal ion binding;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death	cpdP; 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]; K01120	phosphodiesterase 8A [Source:HGNC Symbol%3BAcc:HGNC:8793]
ENSG00000138594	34.51	38.46	38.19	31.20	33.40	34.83	0.169334993245134	5.21656392134347	0.0282807684994893	0.218042968561591	15:51829627-51947295:+	TMOD3	15;GO:0003779,molecular_function actin binding;GO:0005523,molecular_function tropomyosin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005865,cellular_component striated muscle thin filament;GO:0005913,cellular_component cell-cell adherens junction;GO:0006936,biological_process muscle contraction;GO:0007015,biological_process actin filament organization;GO:0030036,biological_process actin cytoskeleton organization;GO:0030239,biological_process myofibril assembly;GO:0048821,biological_process erythrocyte development;GO:0051694,biological_process pointed-end actin filament capping;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:1901992,biological_process positive regulation of mitotic cell cycle phase transition	NA	tropomodulin 3 [Source:HGNC Symbol%3BAcc:HGNC:11873]
ENSG00000125505	90.19	96.79	90.96	81.38	88.57	83.59	0.143300744834652	7.04022523207379	0.0284387383797829	0.219087385368075	19:54173411-54189882:-	MBOAT7	16;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0021591,biological_process ventricular system development;GO:0021819,biological_process layer formation in cerebral cortex;GO:0036149,biological_process phosphatidylinositol acyl-chain remodeling;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0071617,molecular_function lysophospholipid acyltransferase activity	MBOAT7; lysophospholipid acyltransferase 7 [EC:2.3.1.-]; K13516	membrane bound O-acyltransferase domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:15505]
ENSG00000083223	8.83	10.27	8.71	7.29	8.43	8.71	0.192355801347232	5.29342592488328	0.0284515318789444	0.219087385368075	9:86287732-86354454:-	ZCCHC6	12;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0031123,biological_process RNA 3'-end processing;GO:0046872,molecular_function metal ion binding;GO:0050265,molecular_function RNA uridylyltransferase activity	NA	zinc finger CCHC-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:25817]
ENSG00000113522	25.41	24.90	25.71	28.85	26.19	29.92	-0.148243165717112	6.82037012804411	0.0285800074846884	0.219940255987252	5:132556018-132646344:+	RAD50	53;GO:0000014,molecular_function single-stranded DNA endodeoxyribonuclease activity;GO:0000019,biological_process regulation of mitotic recombination;GO:0000166,molecular_function nucleotide binding;GO:0000722,biological_process telomere maintenance via recombination;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000790,cellular_component nuclear chromatin;GO:0000794,cellular_component condensed nuclear chromosome;GO:0003677,molecular_function DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004017,molecular_function adenylate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007004,biological_process telomere maintenance via telomerase;GO:0007049,biological_process cell cycle;GO:0007131,biological_process reciprocal meiotic recombination;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030674,molecular_function protein binding, bridging;GO:0030870,cellular_component Mre11 complex;GO:0031860,biological_process telomeric 3' overhang formation;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0032508,biological_process DNA duplex unwinding;GO:0033674,biological_process positive regulation of kinase activity;GO:0035861,cellular_component site of double-strand break;GO:0043047,molecular_function single-stranded telomeric DNA binding;GO:0046872,molecular_function metal ion binding;GO:0046939,biological_process nucleotide phosphorylation;GO:0051321,biological_process meiotic cell cycle;GO:0051880,molecular_function G-quadruplex DNA binding;GO:0070192,biological_process chromosome organization involved in meiotic cell cycle;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904354,biological_process negative regulation of telomere capping	RAD50; DNA repair protein RAD50 [EC:3.6.-.-]; K10866	RAD50 double strand break repair protein [Source:HGNC Symbol%3BAcc:HGNC:9816]
ENSG00000167995	3.26	2.85	3.33	3.96	4.70	3.40	-0.331349428427702	3.02005863810762	0.028618796063119	0.220102302064124	11:61949820-61965515:+	BEST1	21;GO:0005229,molecular_function intracellular calcium activated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0007601,biological_process visual perception;GO:0015106,molecular_function bicarbonate transmembrane transporter activity;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0030321,biological_process transepithelial chloride transport;GO:0034220,biological_process ion transmembrane transport;GO:0034707,cellular_component chloride channel complex;GO:0042802,molecular_function identical protein binding;GO:0050896,biological_process response to stimulus;GO:0050908,biological_process detection of light stimulus involved in visual perception;GO:0051924,biological_process regulation of calcium ion transport;GO:1902476,biological_process chloride transmembrane transport	NA	bestrophin 1 [Source:HGNC Symbol%3BAcc:HGNC:12703]
ENSG00000143847	4.21	3.58	4.39	3.70	3.27	3.43	0.248335958061208	3.82162566604163	0.0286410608850789	0.220137144747049	1:203026497-203078740:+	PPFIA4	9;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007269,biological_process neurotransmitter secretion;GO:0009986,cellular_component cell surface;GO:0014047,biological_process glutamate secretion;GO:0045202,cellular_component synapse;GO:0048786,cellular_component presynaptic active zone	NA	PTPRF interacting protein alpha 4 [Source:HGNC Symbol%3BAcc:HGNC:9248]
ENSG00000249459	1.15	1.07	0.90	0.69	0.62	0.75	0.605952159132227	0.877616899393323	0.0286897544409812	0.220374951655879	17:18658428-18682262:-	ZNF286B	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 286B [Source:HGNC Symbol%3BAcc:HGNC:33241]
ENSG00000135111	9.63	8.02	10.73	8.87	6.81	8.14	0.271139748460315	4.29307256096749	0.0287349893345276	0.220581535518118	12:114670253-114684164:-	TBX3	56;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001501,biological_process skeletal system development;GO:0001568,biological_process blood vessel development;GO:0001701,biological_process in utero embryonic development;GO:0001947,biological_process heart looping;GO:0003007,biological_process heart morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003167,biological_process atrioventricular bundle cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007569,biological_process cell aging;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008595,biological_process anterior/posterior axis specification, embryo;GO:0009887,biological_process organ morphogenesis;GO:0010159,biological_process specification of organ position;GO:0019827,biological_process stem cell population maintenance;GO:0021761,biological_process limbic system development;GO:0030539,biological_process male genitalia development;GO:0030540,biological_process female genitalia development;GO:0030857,biological_process negative regulation of epithelial cell differentiation;GO:0030879,biological_process mammary gland development;GO:0032275,biological_process luteinizing hormone secretion;GO:0035050,biological_process embryonic heart tube development;GO:0035108,biological_process limb morphogenesis;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035136,biological_process forelimb morphogenesis;GO:0042127,biological_process regulation of cell proliferation;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045787,biological_process positive regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046884,biological_process follicle-stimulating hormone secretion;GO:0048332,biological_process mesoderm morphogenesis;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060021,biological_process palate development;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0060596,biological_process mammary placode formation;GO:0060923,biological_process cardiac muscle cell fate commitment;GO:0060931,biological_process sinoatrial node cell development;GO:0090398,biological_process cellular senescence;GO:2000648,biological_process positive regulation of stem cell proliferation	TBX3; T-box protein 3; K10177	T-box 3 [Source:HGNC Symbol%3BAcc:HGNC:11602]
ENSG00000100075	126.26	131.93	114.94	111.79	112.50	114.63	0.148861829947028	6.79273435105218	0.0287521891942572	0.220581535518118	22:19175574-19178830:-	SLC25A1	15;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006094,biological_process gluconeogenesis;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0006843,biological_process mitochondrial citrate transport;GO:0015137,molecular_function citrate transmembrane transporter activity;GO:0015142,molecular_function tricarboxylic acid transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035674,biological_process tricarboxylic acid transmembrane transport;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	NA	solute carrier family 25 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10979]
ENSG00000108448	190.09	184.54	190.77	171.98	171.66	177.68	0.129229018314652	7.56513320561443	0.0287910346232096	0.220743120925201	17:18697997-18736118:+	TRIM16L	3;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane	NA	tripartite motif containing 16 like [Source:HGNC Symbol%3BAcc:HGNC:32670]
ENSG00000197114	2.53	2.76	2.03	4.32	2.57	3.31	-0.476257249962219	2.26676361357566	0.0288098240533626	0.220750830848389	20:63707464-63736142:+	ZGPAT	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type and G-patch domain containing [Source:HGNC Symbol%3BAcc:HGNC:15948]
ENSG00000174938	63.97	59.02	64.78	57.35	57.11	57.75	0.137670199754463	7.37877795730339	0.028833552609209	0.220796353200562	16:29871158-29899547:-	SEZ6L2	10;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0008344,biological_process adult locomotory behavior;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0043025,cellular_component neuronal cell body;GO:0060074,biological_process synapse maturation;GO:0090036,biological_process regulation of protein kinase C signaling	NA	seizure related 6 homolog like 2 [Source:HGNC Symbol%3BAcc:HGNC:30844]
ENSG00000173598	27.31	27.81	30.77	28.54	21.37	21.63	0.277356675724755	3.84624094229375	0.0289133077472232	0.221216103653264	12:93377882-93408146:+	NUDT4	34;GO:0000298,molecular_function endopolyphosphatase activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008486,molecular_function diphosphoinositol-polyphosphate diphosphatase activity;GO:0009187,biological_process cyclic nucleotide metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019722,biological_process calcium-mediated signaling;GO:0019935,biological_process cyclic-nucleotide-mediated signaling;GO:0030515,molecular_function snoRNA binding;GO:0034431,molecular_function bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432,molecular_function bis(5'-adenosyl)-pentaphosphatase activity;GO:0035556,biological_process intracellular signal transduction;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046831,biological_process regulation of RNA export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0046907,biological_process intracellular transport;GO:0050072,molecular_function m7G(5')pppN diphosphatase activity;GO:0052840,molecular_function inositol diphosphate tetrakisphosphate diphosphatase activity;GO:0052841,molecular_function inositol bisdiphosphate tetrakisphosphate diphosphatase activity;GO:0052842,molecular_function inositol diphosphate pentakisphosphate diphosphatase activity;GO:0052843,molecular_function inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity;GO:0052844,molecular_function inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity;GO:0052845,molecular_function inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity;GO:0052846,molecular_function inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity;GO:0052847,molecular_function inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0052848,molecular_function inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0071543,biological_process diphosphoinositol polyphosphate metabolic process;GO:1901907,biological_process diadenosine pentaphosphate catabolic process;GO:1901909,biological_process diadenosine hexaphosphate catabolic process;GO:1901911,biological_process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	NA	nudix hydrolase 4 [Source:HGNC Symbol%3BAcc:HGNC:8051]
ENSG00000198301	22.79	21.20	24.48	24.86	25.36	26.93	-0.15739771689928	5.706883966329	0.0289240100079955	0.221216103653264	4:75940949-75990962:-	SDAD1	10;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0003674,molecular_function molecular_function;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0030036,biological_process actin cytoskeleton organization;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis	NA	SDA1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25537]
ENSG00000166164	50.66	48.96	48.84	54.05	55.41	55.04	-0.135814966997604	6.67624385147519	0.0289903829646198	0.221587206736346	16:50313486-50368934:-	BRD7	24;GO:0002039,molecular_function p53 binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016055,biological_process Wnt signaling pathway;GO:0035066,biological_process positive regulation of histone acetylation;GO:0042393,molecular_function histone binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0090544,cellular_component BAF-type complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	BRD7; bromodomain-containing protein 7; K11723	bromodomain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:14310]
ENSG00000112343	80.09	91.52	86.53	93.17	103.41	93.81	-0.159417674959495	6.99685332146497	0.0291191699080068	0.222434619118823	6:25962801-25991226:+	TRIM38	16;GO:0002376,biological_process immune system process;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0046598,biological_process positive regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060333,biological_process interferon-gamma-mediated signaling pathway	NA	tripartite motif containing 38 [Source:HGNC Symbol%3BAcc:HGNC:10059]
ENSG00000163820	7.37	6.38	6.83	6.15	5.96	6.27	0.179757628035606	4.87659045777947	0.0291759556788965	0.222731327086188	3:45917898-45995824:-	FYCO1	18;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0006458,biological_process 'de novo' protein folding;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044183,molecular_function protein binding involved in protein folding;GO:0046872,molecular_function metal ion binding;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule;GO:1901098,biological_process positive regulation of autophagosome maturation	NA	FYVE and coiled-coil domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14673]
ENSG00000169607	20.60	18.00	20.25	22.14	22.53	21.65	-0.155154125640957	5.55125880560553	0.0292362023397005	0.222978639668025	2:112736606-112764677:-	CKAP2L	6;GO:0000922,cellular_component spindle pole;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0072686,cellular_component mitotic spindle	NA	cytoskeleton associated protein 2 like [Source:HGNC Symbol%3BAcc:HGNC:26877]
ENSG00000174567	12.31	7.48	11.34	8.32	6.51	7.81	0.491420189212568	1.90031357776857	0.0292477306602881	0.222978639668025	1:204198159-204214092:-	GOLT1A	7;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport	NA	golgi transport 1A [Source:HGNC Symbol%3BAcc:HGNC:24766]
ENSG00000171208	66.59	70.87	65.10	73.40	76.85	74.83	-0.141895449677916	6.81317672917895	0.0292698065105038	0.222978639668025	16:47077702-47143997:-	NETO2	6;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0045202,cellular_component synapse;GO:2000312,biological_process regulation of kainate selective glutamate receptor activity	NA	neuropilin and tolloid like 2 [Source:HGNC Symbol%3BAcc:HGNC:14644]
ENSG00000198930	9.64	8.15	5.28	6.13	4.40	4.32	0.644172498737402	0.992615904976422	0.0292802048383856	0.222978639668025	X:152727483-152733735:-	CSAG1	NA	NA	chondrosarcoma associated gene 1 [Source:HGNC Symbol%3BAcc:HGNC:24294]
ENSG00000148248	127.48	144.79	124.71	124.34	122.48	107.63	0.173483056989498	6.70270481301445	0.0293802935634703	0.223469638742302	9:133361448-133376166:-	SURF4	16;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0010638,biological_process positive regulation of organelle organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation	NA	surfeit 4 [Source:HGNC Symbol%3BAcc:HGNC:11476]
ENSG00000196305	181.64	149.15	184.49	213.52	173.51	211.30	-0.203617322761817	9.48096808335799	0.0293806856060128	0.223469638742302	9:92210206-92293756:-	IARS	19;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0001649,biological_process osteoblast differentiation;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004822,molecular_function isoleucine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006428,biological_process isoleucyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0051020,molecular_function GTPase binding;GO:0070062,cellular_component extracellular exosome	IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]; K01870	isoleucyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:5330]
ENSG00000185015	7.19	9.48	7.96	9.53	10.90	10.47	-0.330745906235006	2.8902839321551	0.0294078435266526	0.223539229452749	8:85220586-85284073:+	CA13	9;GO:0004089,molecular_function carbonate dehydratase activity;GO:0005829,cellular_component cytosol;GO:0006730,biological_process one-carbon metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015701,biological_process bicarbonate transport;GO:0016829,molecular_function lyase activity;GO:0043209,cellular_component myelin sheath;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	CA; carbonic anhydrase [EC:4.2.1.1]; K01672	carbonic anhydrase 13 [Source:HGNC Symbol%3BAcc:HGNC:14914]
ENSG00000177917	50.17	44.34	47.27	52.50	52.78	54.56	-0.156881667187522	5.2706169893397	0.029463905277606	0.223828308574617	2:152717892-152761253:+	ARL6IP6	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ADP ribosylation factor like GTPase 6 interacting protein 6 [Source:HGNC Symbol%3BAcc:HGNC:24048]
ENSG00000165672	205.53	229.46	185.63	237.97	245.50	222.03	-0.174609702809724	7.40870940587126	0.0295751454351333	0.224535951245449	10:119167702-119178833:-	PRDX3	41;GO:0001893,biological_process maternal placenta development;GO:0004601,molecular_function peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0007005,biological_process mitochondrion organization;GO:0008022,molecular_function protein C-terminus binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008379,molecular_function thioredoxin peroxidase activity;GO:0008385,cellular_component IkappaB kinase complex;GO:0008785,molecular_function alkyl hydroperoxide reductase activity;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0018171,biological_process peptidyl-cysteine oxidation;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0030099,biological_process myeloid cell differentiation;GO:0032496,biological_process response to lipopolysaccharide;GO:0033673,biological_process negative regulation of kinase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0042542,biological_process response to hydrogen peroxide;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0042802,molecular_function identical protein binding;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0045454,biological_process cell redox homeostasis;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0051920,molecular_function peroxiredoxin activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]; K03386	peroxiredoxin 3 [Source:HGNC Symbol%3BAcc:HGNC:9354]
ENSG00000128165	5.73	1.94	5.64	2.87	2.39	2.85	0.760957876571025	0.82482341406804	0.0295988941739921	0.224578895710125	22:50481555-50486440:+	ADM2	11;GO:0001525,biological_process angiogenesis;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0006468,biological_process protein phosphorylation;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007586,biological_process digestion;GO:0007631,biological_process feeding behavior;GO:0010628,biological_process positive regulation of gene expression;GO:0032403,molecular_function protein complex binding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045776,biological_process negative regulation of blood pressure	NA	adrenomedullin 2 [Source:HGNC Symbol%3BAcc:HGNC:28898]
ENSG00000105619	18.61	15.36	17.26	21.31	18.59	21.22	-0.234453566351155	3.85209742669556	0.0296585161958753	0.2247813284579	19:54107012-54115675:-	TFPT	15;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016579,biological_process protein deubiquitination;GO:0031011,cellular_component Ino80 complex;GO:0031965,cellular_component nuclear membrane;GO:0097190,biological_process apoptotic signaling pathway	NA	TCF3 fusion partner [Source:HGNC Symbol%3BAcc:HGNC:13630]
ENSG00000112406	3.60	3.40	2.98	4.32	4.00	4.27	-0.325027684524858	2.65621861721342	0.0296617913489117	0.2247813284579	6:139135111-139180802:+	HECA	7;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0030323,biological_process respiratory tube development;GO:0045930,biological_process negative regulation of mitotic cell cycle	NA	hdc homolog%2C cell cycle regulator [Source:HGNC Symbol%3BAcc:HGNC:21041]
ENSG00000198121	24.71	29.58	25.75	22.63	25.07	22.34	0.197910130856297	4.7747505005882	0.0297050415085975	0.224971739015388	9:110873262-111038458:-	LPAR1	50;GO:0000187,biological_process activation of MAPK activity;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007202,biological_process activation of phospholipase C activity;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007420,biological_process brain development;GO:0008289,molecular_function lipid binding;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0010942,biological_process positive regulation of cell death;GO:0010977,biological_process negative regulation of neuron projection development;GO:0014003,biological_process oligodendrocyte development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021549,biological_process cerebellum development;GO:0021554,biological_process optic nerve development;GO:0022008,biological_process neurogenesis;GO:0022038,biological_process corpus callosum development;GO:0030139,cellular_component endocytic vesicle;GO:0030165,molecular_function PDZ domain binding;GO:0030818,biological_process negative regulation of cAMP biosynthetic process;GO:0032060,biological_process bleb assembly;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035727,molecular_function lysophosphatidic acid binding;GO:0042552,biological_process myelination;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0060326,biological_process cell chemotaxis;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0070915,molecular_function lysophosphatidic acid receptor activity;GO:0071453,biological_process cellular response to oxygen levels;GO:0071673,biological_process positive regulation of smooth muscle cell chemotaxis;GO:1904566,biological_process cellular response to 1-oleoyl-sn-glycerol 3-phosphate	LPAR1, EDG2; lysophosphatidic acid receptor 1; K04289	lysophosphatidic acid receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:3166]
ENSG00000260027	27.12	27.01	27.36	30.59	30.29	33.16	-0.195754729219278	4.26613386751809	0.0298940522677381	0.226265165121605	17:48607226-48633572:-	HOXB7	19;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016604,cellular_component nuclear body;GO:0030099,biological_process myeloid cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis	NA	homeobox B7 [Source:HGNC Symbol%3BAcc:HGNC:5118]
ENSG00000050344	45.22	43.00	45.54	49.91	47.74	50.95	-0.13901276756945	6.64919847480661	0.029935931427212	0.226444068742219	7:26152239-26187125:+	NFE2L3	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	nuclear factor%2C erythroid 2 like 3 [Source:HGNC Symbol%3BAcc:HGNC:7783]
ENSG00000182795	3.96	4.08	3.92	4.53	6.39	4.49	-0.35295697012495	3.06777515667823	0.0299576773966227	0.226470553912471	1:207018520-207032756:-	C1orf116	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome	NA	chromosome 1 open reading frame 116 [Source:HGNC Symbol%3BAcc:HGNC:28667]
ENSG00000126243	3.60	3.14	2.46	1.67	2.70	2.43	0.448970395093839	2.36699895054729	0.0300096857425916	0.226666835349345	19:35935357-35945767:+	LRFN3	15;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007409,biological_process axonogenesis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0042734,cellular_component presynaptic membrane;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	leucine rich repeat and fibronectin type III domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28370]
ENSG00000092529	1.56	1.76	2.50	1.57	1.43	1.30	0.454586721949486	2.23733962984979	0.030020162516259	0.226666835349345	15:42359499-42412318:+	CAPN3	52;GO:0003824,molecular_function catalytic activity;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007517,biological_process muscle organ development;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008307,molecular_function structural constituent of muscle;GO:0012501,biological_process programmed cell death;GO:0014718,biological_process positive regulation of satellite cell activation involved in skeletal muscle regeneration;GO:0014850,biological_process response to muscle activity;GO:0016787,molecular_function hydrolase activity;GO:0030016,cellular_component myofibril;GO:0030018,cellular_component Z disc;GO:0030239,biological_process myofibril assembly;GO:0030315,cellular_component T-tubule;GO:0031402,molecular_function sodium ion binding;GO:0031432,molecular_function titin binding;GO:0032947,molecular_function protein complex scaffold;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0045214,biological_process sarcomere organization;GO:0045661,biological_process regulation of myoblast differentiation;GO:0045862,biological_process positive regulation of proteolysis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046872,molecular_function metal ion binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0051592,biological_process response to calcium ion;GO:0055103,molecular_function ligase regulator activity;GO:0061061,biological_process muscle structure development;GO:0070315,biological_process G1 to G0 transition involved in cell differentiation;GO:0071277,biological_process cellular response to calcium ion;GO:0071472,biological_process cellular response to salt stress;GO:0072657,biological_process protein localization to membrane;GO:0097264,biological_process self proteolysis;GO:2001015,biological_process negative regulation of skeletal muscle cell differentiation	NA	calpain 3 [Source:HGNC Symbol%3BAcc:HGNC:1480]
ENSG00000124588	61.61	66.69	60.39	74.59	66.64	70.76	-0.159677484808086	5.72769767928069	0.030044986025294	0.226716359593905	6:2987986-3028869:+	NQO2	23;GO:0001512,molecular_function dihydronicotinamide riboside quinone reductase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006805,biological_process xenobiotic metabolic process;GO:0007613,biological_process memory;GO:0008270,molecular_function zinc ion binding;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016661,molecular_function oxidoreductase activity, acting on other nitrogenous compounds as donors;GO:0031404,molecular_function chloride ion binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071949,molecular_function FAD binding;GO:1904408,molecular_function melatonin binding;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1905594,molecular_function resveratrol binding;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	NA	N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:7856]
ENSG00000172830	23.10	21.33	22.78	17.87	21.73	20.43	0.176956195032825	5.41488010422443	0.0301611377483421	0.227454558244332	11:67303447-67312607:+	SSH3	15;GO:0003779,molecular_function actin binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006470,biological_process protein dephosphorylation;GO:0008064,biological_process regulation of actin polymerization or depolymerization;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0050770,biological_process regulation of axonogenesis	SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]; K05766	slingshot protein phosphatase 3 [Source:HGNC Symbol%3BAcc:HGNC:30581]
ENSG00000094975	13.58	12.92	13.58	11.86	12.31	12.50	0.141223297970949	5.80263613609967	0.0302098302418324	0.227683438246427	1:172532348-172611833:+	SUCO	10;GO:0001503,biological_process ossification;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030867,cellular_component rough endoplasmic reticulum membrane;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0046850,biological_process regulation of bone remodeling	NA	SUN domain containing ossification factor [Source:HGNC Symbol%3BAcc:HGNC:1240]
ENSG00000073921	123.89	126.82	120.86	108.58	117.87	115.09	0.133009020038948	7.94430707180985	0.030341665142456	0.228538282410987	11:85957683-86069882:-	PICALM	61;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005905,cellular_component clathrin-coated pit;GO:0006461,biological_process protein complex assembly;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007409,biological_process axonogenesis;GO:0007611,biological_process learning or memory;GO:0008283,biological_process cell proliferation;GO:0009986,cellular_component cell surface;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016188,biological_process synaptic vesicle maturation;GO:0016192,biological_process vesicle-mediated transport;GO:0016197,biological_process endosomal transport;GO:0017137,molecular_function Rab GTPase binding;GO:0030097,biological_process hemopoiesis;GO:0030100,biological_process regulation of endocytosis;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030132,cellular_component clathrin coat of coated pit;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030276,molecular_function clathrin binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031623,biological_process receptor internalization;GO:0031982,cellular_component vesicle;GO:0032050,molecular_function clathrin heavy chain binding;GO:0032880,biological_process regulation of protein localization;GO:0035459,biological_process cargo loading into vesicle;GO:0035615,molecular_function clathrin adaptor activity;GO:0042734,cellular_component presynaptic membrane;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045056,biological_process transcytosis;GO:0045211,cellular_component postsynaptic membrane;GO:0045296,molecular_function cadherin binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048261,biological_process negative regulation of receptor-mediated endocytosis;GO:0048268,biological_process clathrin coat assembly;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048813,biological_process dendrite morphogenesis;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0055072,biological_process iron ion homeostasis;GO:0061024,biological_process membrane organization;GO:0070381,cellular_component endosome to plasma membrane transport vesicle;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0090647,biological_process modulation of age-related behavioral decline;GO:0097418,cellular_component neurofibrillary tangle;GO:0098711,biological_process iron ion import across plasma membrane;GO:1900223,biological_process positive regulation of beta-amyloid clearance;GO:1901216,biological_process positive regulation of neuron death;GO:1902004,biological_process positive regulation of beta-amyloid formation;GO:1902959,biological_process regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902961,biological_process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902963,biological_process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	NA	phosphatidylinositol binding clathrin assembly protein [Source:HGNC Symbol%3BAcc:HGNC:15514]
ENSG00000078804	3.32	6.52	4.01	2.72	3.91	2.34	0.611211910963567	1.37349778444432	0.0304204308096273	0.228992606209766	20:34704289-34713439:+	TP53INP2	19;GO:0000045,biological_process autophagosome assembly;GO:0001649,biological_process osteoblast differentiation;GO:0001894,biological_process tissue homeostasis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006914,biological_process autophagy;GO:0010508,biological_process positive regulation of autophagy;GO:0016236,biological_process macroautophagy;GO:0016605,cellular_component PML body;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043130,molecular_function ubiquitin binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:1903828,biological_process negative regulation of cellular protein localization	NA	tumor protein p53 inducible nuclear protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16104]
ENSG00000163479	226.45	235.08	226.31	213.21	216.60	200.92	0.136343571809424	7.31179624202241	0.0304688065609771	0.2292177550554	1:156009047-156020959:-	SSR2	5;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	SSR2; translocon-associated protein subunit beta; K13250	signal sequence receptor subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:11324]
ENSG00000176142	27.69	30.51	29.78	26.63	26.07	26.92	0.15252669917894	5.40244489604783	0.0306613735421148	0.230526729120697	3:119429499-119468830:-	TMEM39A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 39A [Source:HGNC Symbol%3BAcc:HGNC:25600]
ENSG00000120051	0.56	0.43	0.39	0.25	0.31	0.21	0.840566670514772	0.140469807989745	0.0306828321801828	0.230548423639594	10:104353763-104455090:+	CFAP58	4;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005929,cellular_component cilium;GO:0042995,cellular_component cell projection	NA	cilia and flagella associated protein 58 [Source:HGNC Symbol%3BAcc:HGNC:26676]
ENSG00000173193	24.65	21.08	25.97	28.68	24.18	29.91	-0.194037695219441	7.15652664228216	0.0307139616475295	0.230642713811727	3:122680617-122730840:+	PARP14	11;GO:0003723,molecular_function RNA binding;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol%3BAcc:HGNC:29232]
ENSG00000100462	47.06	45.32	46.54	53.71	53.05	48.29	-0.145802555781283	6.65797310687387	0.0307958390388369	0.231059528233338	14:22920510-22929585:-	PRMT5	46;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006479,biological_process protein methylation;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008168,molecular_function methyltransferase activity;GO:0008283,biological_process cell proliferation;GO:0008327,molecular_function methyl-CpG binding;GO:0008469,molecular_function histone-arginine N-methyltransferase activity;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018216,biological_process peptidyl-arginine methylation;GO:0019918,biological_process peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0032259,biological_process methylation;GO:0032403,molecular_function protein complex binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0034709,cellular_component methylosome;GO:0035097,cellular_component histone methyltransferase complex;GO:0035243,molecular_function protein-arginine omega-N symmetric methyltransferase activity;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0042118,biological_process endothelial cell activation;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043234,cellular_component protein complex;GO:0043985,biological_process histone H4-R3 methylation;GO:0044020,molecular_function histone methyltransferase activity (H4-R3 specific);GO:0044030,biological_process regulation of DNA methylation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0046982,molecular_function protein heterodimerization activity;GO:0048511,biological_process rhythmic process;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0090161,biological_process Golgi ribbon formation;GO:0097421,biological_process liver regeneration;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription;GO:1904992,biological_process positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	PRMT5, HSL7; type II protein arginine methyltransferase [EC:2.1.1.320]; K02516	protein arginine methyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:10894]
ENSG00000131747	94.89	106.91	89.40	105.63	120.71	104.87	-0.174408895650278	8.89720381766114	0.0308187063692315	0.231059528233338	17:40388515-40417950:-	TOP2A	50;GO:0000166,molecular_function nucleotide binding;GO:0000228,cellular_component nuclear chromosome;GO:0000287,molecular_function magnesium ion binding;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000793,cellular_component condensed chromosome;GO:0000819,biological_process sister chromatid segregation;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003916,molecular_function DNA topoisomerase activity;GO:0003918,molecular_function DNA topoisomerase type II (ATP-hydrolyzing) activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0006259,biological_process DNA metabolic process;GO:0006265,biological_process DNA topological change;GO:0006266,biological_process DNA ligation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007059,biological_process chromosome segregation;GO:0008022,molecular_function protein C-terminus binding;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008144,molecular_function drug binding;GO:0008301,molecular_function DNA binding, bending;GO:0009330,cellular_component DNA topoisomerase complex (ATP-hydrolyzing);GO:0016853,molecular_function isomerase activity;GO:0016925,biological_process protein sumoylation;GO:0019035,cellular_component viral integration complex;GO:0019899,molecular_function enzyme binding;GO:0030261,biological_process chromosome condensation;GO:0030263,biological_process apoptotic chromosome condensation;GO:0040016,biological_process embryonic cleavage;GO:0042752,biological_process regulation of circadian rhythm;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043130,molecular_function ubiquitin binding;GO:0043234,cellular_component protein complex;GO:0044774,biological_process mitotic DNA integrity checkpoint;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045870,biological_process positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048511,biological_process rhythmic process	TOP2; DNA topoisomerase II [EC:5.6.2.2]; K03164	topoisomerase (DNA) II alpha [Source:HGNC Symbol%3BAcc:HGNC:11989]
ENSG00000167964	4.56	3.65	5.19	2.93	3.03	4.12	0.43141999889149	2.25824786545677	0.030837505984967	0.231059528233338	16:2140802-2154165:+	RAB26	23;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0009306,biological_process protein secretion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017157,biological_process regulation of exocytosis;GO:0019002,molecular_function GMP binding;GO:0030658,cellular_component transport vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035272,biological_process exocrine system development;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0045055,biological_process regulated exocytosis	NA	RAB26%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:14259]
ENSG00000256269	17.73	19.77	17.31	21.50	19.15	22.68	-0.20373989410613	4.65485224079818	0.0308672306935447	0.231059528233338	11:119084865-119093549:+	HMBS	9;GO:0004418,molecular_function hydroxymethylbilane synthase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0018160,biological_process peptidyl-pyrromethane cofactor linkage;GO:0033014,biological_process tetrapyrrole biosynthetic process	hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61]; K01749	hydroxymethylbilane synthase [Source:HGNC Symbol%3BAcc:HGNC:4982]
ENSG00000116679	50.68	51.58	47.40	47.14	45.81	43.27	0.14671372128226	6.5944915287667	0.0308696397712148	0.231059528233338	1:185296387-185317329:-	IVNS1ABP	13;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008380,biological_process RNA splicing;GO:0009615,biological_process response to virus;GO:0015629,cellular_component actin cytoskeleton;GO:0016032,biological_process viral process;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	NA	influenza virus NS1A binding protein [Source:HGNC Symbol%3BAcc:HGNC:16951]
ENSG00000149294	31.49	27.43	31.97	27.32	26.83	28.28	0.154802177042955	6.75617433638069	0.0308811534148963	0.231059528233338	11:112961246-113278436:+	NCAM1	19;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0001618,molecular_function virus receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007411,biological_process axon guidance;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0031225,cellular_component anchored component of membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046718,biological_process viral entry into host cell;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome	NCAM, CD56; neural cell adhesion molecule; K06491	neural cell adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:7656]
ENSG00000108813	1.31	1.55	1.79	3.03	2.28	1.95	-0.629434582070742	0.90647462831054	0.0310000791952553	0.231681330371406	17:49968969-49974959:+	DLX4	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0043565,molecular_function sequence-specific DNA binding	NA	distal-less homeobox 4 [Source:HGNC Symbol%3BAcc:HGNC:2917]
ENSG00000105778	24.88	26.03	27.97	27.88	29.63	31.00	-0.154590497904723	5.87050082369525	0.0310015862198426	0.231681330371406	7:32495425-32588721:+	AVL9	5;GO:0005768,cellular_component endosome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0055037,cellular_component recycling endosome	NA	AVL9 cell migration associated [Source:HGNC Symbol%3BAcc:HGNC:28994]
ENSG00000185222	247.87	300.48	237.79	215.02	251.84	224.48	0.194214388856836	6.26402966757258	0.0310651424187843	0.232016614226456	X:103356451-103358451:+	TCEAL9	5;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0050699,molecular_function WW domain binding	NA	transcription elongation factor A like 9 [Source:HGNC Symbol%3BAcc:HGNC:30084]
ENSG00000092847	4.10	4.86	4.38	4.77	5.60	5.59	-0.25584163682325	3.7128544277627	0.0311412080962612	0.232444868369748	1:35869807-35930528:+	AGO1	40;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000993,molecular_function RNA polymerase II core binding;GO:0001047,molecular_function core promoter binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010586,biological_process miRNA metabolic process;GO:0010628,biological_process positive regulation of gene expression;GO:0016442,cellular_component RISC complex;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035194,biological_process posttranscriptional gene silencing by RNA;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0035198,molecular_function miRNA binding;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0035280,biological_process miRNA loading onto RISC involved in gene silencing by miRNA;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070578,cellular_component RISC-loading complex;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling	NA	argonaute 1%2C RISC catalytic component [Source:HGNC Symbol%3BAcc:HGNC:3262]
ENSG00000112186	19.21	20.06	18.51	15.16	19.18	16.11	0.206298872853173	4.7315680815296	0.0311674778257559	0.232501143179752	6:17393215-17557792:+	CAP2	14;GO:0000902,biological_process cell morphogenesis;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007165,biological_process signal transduction;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0008154,biological_process actin polymerization or depolymerization;GO:0008179,molecular_function adenylate cyclase binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0042802,molecular_function identical protein binding	NA	cyclase associated actin cytoskeleton regulatory protein 2 [Source:HGNC Symbol%3BAcc:HGNC:20039]
ENSG00000145391	14.57	15.92	13.64	15.97	16.60	18.57	-0.207917045637793	4.52020041176552	0.0311964222208883	0.232577290707439	4:139495940-139606699:-	SETD7	25;GO:0002039,molecular_function p53 binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0018027,biological_process peptidyl-lysine dimethylation;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0045471,biological_process response to ethanol;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051570,biological_process regulation of histone H3-K9 methylation;GO:0070828,biological_process heterochromatin organization	SETD7; [histone H3]-lysine4 N-trimethyltransferase SETD7 [EC:2.1.1.354]; K11431	SET domain containing lysine methyltransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:30412]
ENSG00000128709	21.07	16.56	20.84	17.58	14.29	17.85	0.252260238023825	4.26790527930435	0.0312626338315988	0.232931016657644	2:176122719-176124937:+	HOXD9	25;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007338,biological_process single fertilization;GO:0007519,biological_process skeletal muscle tissue development;GO:0008344,biological_process adult locomotory behavior;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009954,biological_process proximal/distal pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0030879,biological_process mammary gland development;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035136,biological_process forelimb morphogenesis;GO:0035137,biological_process hindlimb morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0048935,biological_process peripheral nervous system neuron development	NA	homeobox D9 [Source:HGNC Symbol%3BAcc:HGNC:5140]
ENSG00000141510	26.29	28.16	27.08	31.31	31.71	28.57	-0.157843331196858	5.54467449778697	0.0312823081009497	0.23293778671691	17:7661778-7687550:-	TP53	135;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000733,biological_process DNA strand renaturation;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000990,molecular_function transcription factor activity, core RNA polymerase binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002020,molecular_function protease binding;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0006983,biological_process ER overload response;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007265,biological_process Ras protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007569,biological_process cell aging;GO:0008104,biological_process protein localization;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008340,biological_process determination of adult lifespan;GO:0010165,biological_process response to X-ray;GO:0010332,biological_process response to gamma radiation;GO:0010628,biological_process positive regulation of gene expression;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016363,cellular_component nuclear matrix;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0031497,biological_process chromatin assembly;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0034644,biological_process cellular response to UV;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035690,biological_process cellular response to drug;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042149,biological_process cellular response to glucose starvation;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042802,molecular_function identical protein binding;GO:0042826,molecular_function histone deacetylase binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043621,molecular_function protein self-association;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046677,biological_process response to antibiotic;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0048511,biological_process rhythmic process;GO:0048512,biological_process circadian behavior;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051087,molecular_function chaperone binding;GO:0051097,biological_process negative regulation of helicase activity;GO:0051262,biological_process protein tetramerization;GO:0051289,biological_process protein homotetramerization;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0051974,biological_process negative regulation of telomerase activity;GO:0070245,biological_process positive regulation of thymocyte apoptotic process;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071456,biological_process cellular response to hypoxia;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071480,biological_process cellular response to gamma radiation;GO:0072331,biological_process signal transduction by p53 class mediator;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0072717,biological_process cellular response to actinomycin D;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0090399,biological_process replicative senescence;GO:0090403,biological_process oxidative stress-induced premature senescence;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:0097252,biological_process oligodendrocyte apoptotic process;GO:0097718,molecular_function disordered domain specific binding;GO:1900119,biological_process positive regulation of execution phase of apoptosis;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902749,biological_process regulation of cell cycle G2/M phase transition;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	TP53, P53; tumor protein p53; K04451	tumor protein p53 [Source:HGNC Symbol%3BAcc:HGNC:11998]
ENSG00000243649	0.36	0.56	0.83	0.25	0.38	0.38	0.783971877878661	0.312520770151558	0.0313192944704941	0.233073382651225	6:31945649-31952084:+	CFB	16;GO:0001848,molecular_function complement binding;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006956,biological_process complement activation;GO:0006957,biological_process complement activation, alternative pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030449,biological_process regulation of complement activation;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	CFB; complement factor B [EC:3.4.21.47]; K01335	complement factor B [Source:HGNC Symbol%3BAcc:HGNC:1037]
ENSG00000139174	21.56	24.00	20.73	22.92	28.72	24.54	-0.191400628598383	5.89081653141899	0.0313825892334905	0.233404481818645	12:42456756-42590355:-	PRICKLE1	18;GO:0001843,biological_process neural tube closure;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031965,cellular_component nuclear membrane;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035904,biological_process aorta development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060976,biological_process coronary vasculature development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000691,biological_process negative regulation of cardiac muscle cell myoblast differentiation	PRICKLE; prickle; K04511	prickle planar cell polarity protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17019]
ENSG00000115414	7904.18	7134.39	8155.11	8946.50	8178.42	8730.59	-0.145074074367226	15.8969645072855	0.0314040079187068	0.23342392233228	2:215360439-215436172:-	FN1	55;GO:0001525,biological_process angiogenesis;GO:0001932,biological_process regulation of protein phosphorylation;GO:0002020,molecular_function protease binding;GO:0002576,biological_process platelet degranulation;GO:0005102,molecular_function receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005577,cellular_component fibrinogen complex;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005605,cellular_component basal lamina;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006953,biological_process acute-phase response;GO:0007044,biological_process cell-substrate junction assembly;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007161,biological_process calcium-independent cell-matrix adhesion;GO:0008022,molecular_function protein C-terminus binding;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009611,biological_process response to wounding;GO:0010628,biological_process positive regulation of gene expression;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016324,cellular_component apical plasma membrane;GO:0016504,molecular_function peptidase activator activity;GO:0018149,biological_process peptide cross-linking;GO:0019899,molecular_function enzyme binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0031093,cellular_component platelet alpha granule lumen;GO:0033622,biological_process integrin activation;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035987,biological_process endodermal cell differentiation;GO:0042060,biological_process wound healing;GO:0042802,molecular_function identical protein binding;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045773,biological_process positive regulation of axon extension;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0050900,biological_process leukocyte migration;GO:0051087,molecular_function chaperone binding;GO:0051702,biological_process interaction with symbiont;GO:0052047,biological_process interaction with other organism via secreted substance involved in symbiotic interaction;GO:0070062,cellular_component extracellular exosome;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0072562,cellular_component blood microparticle;GO:0097718,molecular_function disordered domain specific binding;GO:1904237,biological_process positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:2001202,biological_process negative regulation of transforming growth factor-beta secretion	FN1; fibronectin 1; K05717	fibronectin 1 [Source:HGNC Symbol%3BAcc:HGNC:3778]
ENSG00000188153	7.41	6.95	6.99	6.02	7.00	6.08	0.176121920389833	5.11433874231054	0.0314306008615582	0.233481776477871	X:108439843-108697545:+	COL4A5	13;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005587,cellular_component collagen type IV trimer;GO:0005604,cellular_component basement membrane;GO:0005605,cellular_component basal lamina;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007528,biological_process neuromuscular junction development;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0031594,cellular_component neuromuscular junction;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway	COL4A; collagen, type IV, alpha; K06237	collagen type IV alpha 5 chain [Source:HGNC Symbol%3BAcc:HGNC:2207]
ENSG00000141068	1.44	0.91	1.30	2.01	1.09	2.35	-0.557749082619224	2.28155823597282	0.0314537982290708	0.233514352522402	17:27456713-27626438:+	KSR1	23;GO:0000165,biological_process MAPK cascade;GO:0004672,molecular_function protein kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005078,molecular_function MAP-kinase scaffold activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007265,biological_process Ras protein signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0019933,biological_process cAMP-mediated signaling;GO:0032587,cellular_component ruffle membrane;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0046872,molecular_function metal ion binding	KSR1; kinase suppressor of Ras 1; K14958	kinase suppressor of ras 1 [Source:HGNC Symbol%3BAcc:HGNC:6465]
ENSG00000143443	3.80	3.74	3.31	5.20	4.15	4.95	-0.390479627230667	2.15578182278706	0.0316453742009298	0.234796192442404	1:151047739-151051986:+	C1orf56	1;GO:0005576,cellular_component extracellular region	NA	chromosome 1 open reading frame 56 [Source:HGNC Symbol%3BAcc:HGNC:26045]
ENSG00000259431	16.27	17.73	15.25	14.65	14.18	12.23	0.269734941885218	3.39045111710642	0.0316817611675175	0.234925747534286	14:23555987-23560271:+	THTPA	11;GO:0000287,molecular_function magnesium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006772,biological_process thiamine metabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0042357,biological_process thiamine diphosphate metabolic process;GO:0042723,biological_process thiamine-containing compound metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050333,molecular_function thiamin-triphosphatase activity	THTPA; thiamine-triphosphatase [EC:3.6.1.28]; K05307	thiamine triphosphatase [Source:HGNC Symbol%3BAcc:HGNC:18987]
ENSG00000082213	18.66	19.40	19.19	16.73	17.69	16.80	0.171139899124203	4.68826438507761	0.0317506461669084	0.235295982608856	5:31532265-31555058:+	C5orf22	1;GO:0005515,molecular_function protein binding	NA	chromosome 5 open reading frame 22 [Source:HGNC Symbol%3BAcc:HGNC:25639]
ENSG00000196757	14.54	16.76	15.21	14.07	13.68	13.81	0.16834351330406	5.03967180593803	0.0317912162181274	0.235456066178768	19:11925067-11950773:+	ZNF700	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 700 [Source:HGNC Symbol%3BAcc:HGNC:25292]
ENSG00000164543	108.61	101.41	106.31	98.08	90.25	100.66	0.142871905994476	6.97228196161738	0.0318415294551988	0.235688076999035	7:43582757-43626786:+	STK17A	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:2000271,biological_process positive regulation of fibroblast apoptotic process;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	NA	serine/threonine kinase 17a [Source:HGNC Symbol%3BAcc:HGNC:11395]
ENSG00000138119	185.35	183.38	180.23	167.60	172.37	169.62	0.119113749345669	10.1168625522276	0.0318884973130048	0.235895063853593	10:93306428-93482317:-	MYOF	19;GO:0001778,biological_process plasma membrane repair;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006936,biological_process muscle contraction;GO:0007520,biological_process myoblast fusion;GO:0008015,biological_process blood circulation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030947,biological_process regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031965,cellular_component nuclear membrane;GO:0034605,biological_process cellular response to heat;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome	NA	myoferlin [Source:HGNC Symbol%3BAcc:HGNC:3656]
ENSG00000185038	0.11	0.24	0.23	0.06	0.10	0.14	0.919444507349596	-0.172559759774602	0.0319458409915325	0.235941800070394	2:233775678-233833423:+	MROH2A	NA	NA	maestro heat like repeat family member 2A [Source:HGNC Symbol%3BAcc:HGNC:27936]
ENSG00000090263	136.37	108.79	120.35	145.74	137.61	135.11	-0.177306543477684	5.38651127378387	0.0319460557029389	0.235941800070394	7:141002609-141015228:-	MRPS33	9;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S33 [Source:HGNC Symbol%3BAcc:HGNC:16634]
ENSG00000162704	170.60	186.70	164.28	149.43	168.01	153.84	0.155874819021548	6.2953210357719	0.0319846873611772	0.235941800070394	1:183620845-183635757:-	ARPC5	34;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0014909,biological_process smooth muscle cell migration;GO:0015629,cellular_component actin cytoskeleton;GO:0016477,biological_process cell migration;GO:0021769,biological_process orbitofrontal cortex development;GO:0030011,biological_process maintenance of cell polarity;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030426,cellular_component growth cone;GO:0030833,biological_process regulation of actin filament polymerization;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0034774,cellular_component secretory granule lumen;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043312,biological_process neutrophil degranulation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0051639,biological_process actin filament network formation;GO:0061024,biological_process membrane organization;GO:0061842,biological_process microtubule organizing center localization;GO:0070062,cellular_component extracellular exosome;GO:0097581,biological_process lamellipodium organization;GO:1904813,cellular_component ficolin-1-rich granule lumen	ARPC5; actin related protein 2/3 complex, subunit 5; K05754	actin related protein 2/3 complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:708]
ENSG00000065665	8.10	7.79	8.39	6.96	7.15	6.72	0.236867273106615	3.57915352501042	0.0319862751018562	0.235941800070394	10:12129636-12169961:+	SEC61A2	11;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043022,molecular_function ribosome binding	SEC61A; protein transport protein SEC61 subunit alpha; K10956	Sec61 translocon alpha 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:17702]
ENSG00000154380	36.39	34.92	37.27	39.90	39.05	41.54	-0.137337402402443	6.63539406012487	0.0319898533407293	0.235941800070394	1:225486834-225653142:-	ENAH	15;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007411,biological_process axon guidance;GO:0017124,molecular_function SH3 domain binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0050699,molecular_function WW domain binding	ENAH, MENA; enabled; K05746	ENAH%2C actin regulator [Source:HGNC Symbol%3BAcc:HGNC:18271]
ENSG00000185917	15.12	14.40	14.27	17.03	15.50	18.04	-0.19604685533893	4.412341520512	0.0320453361672403	0.236074755891206	21:36034540-36079389:-	SETD4	8;GO:0005730,cellular_component nucleolus;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018023,biological_process peptidyl-lysine trimethylation;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0032259,biological_process methylation;GO:0042254,biological_process ribosome biogenesis	NA	SET domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:1258]
ENSG00000115252	3.26	4.36	3.28	2.32	3.54	2.25	0.428028686474516	2.56270594359993	0.0320501813913562	0.236074755891206	2:182140035-182523192:-	PDE1A	19;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004117,molecular_function calmodulin-dependent cyclic-nucleotide phosphodiesterase activity;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006198,biological_process cAMP catabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0030553,molecular_function cGMP binding;GO:0034391,biological_process regulation of smooth muscle cell apoptotic process;GO:0043025,cellular_component neuronal cell body;GO:0046069,biological_process cGMP catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047555,molecular_function 3',5'-cyclic-GMP phosphodiesterase activity;GO:0048101,molecular_function calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity;GO:0048660,biological_process regulation of smooth muscle cell proliferation	PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]; K13755	phosphodiesterase 1A [Source:HGNC Symbol%3BAcc:HGNC:8774]
ENSG00000187164	38.78	40.62	36.53	31.43	38.60	33.64	0.171833670651029	6.11753389738306	0.0320649350223615	0.236074755891206	10:116881481-117126586:-	SHTN1	32;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0006930,biological_process substrate-dependent cell migration, cell extension;GO:0007265,biological_process Ras protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007409,biological_process axonogenesis;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019894,molecular_function kinesin binding;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031252,cellular_component cell leading edge;GO:0032488,biological_process Cdc42 protein signal transduction;GO:0038007,biological_process netrin-activated signaling pathway;GO:0042995,cellular_component cell projection;GO:0043204,cellular_component perikaryon;GO:0044295,cellular_component axonal growth cone;GO:0045296,molecular_function cadherin binding;GO:0045773,biological_process positive regulation of axon extension;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048812,biological_process neuron projection morphogenesis;GO:0051015,molecular_function actin filament binding;GO:0060327,biological_process cytoplasmic actin-based contraction involved in cell motility;GO:0061163,biological_process endoplasmic reticulum polarization;GO:0061573,biological_process actin filament bundle retrograde transport;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2001222,biological_process regulation of neuron migration;GO:2001224,biological_process positive regulation of neuron migration	NA	shootin 1 [Source:HGNC Symbol%3BAcc:HGNC:29319]
ENSG00000134809	69.58	68.31	62.15	74.04	75.28	81.78	-0.199079902819858	4.29187895113782	0.0321451203475801	0.236524824466219	11:57528462-57530803:-	TIMM10	19;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0007605,biological_process sensory perception of sound;GO:0008270,molecular_function zinc ion binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0042719,cellular_component mitochondrial intermembrane space protein transporter complex;GO:0042803,molecular_function protein homodimerization activity;GO:0045039,biological_process protein import into mitochondrial inner membrane;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0072321,biological_process chaperone-mediated protein transport	NA	translocase of inner mitochondrial membrane 10 [Source:HGNC Symbol%3BAcc:HGNC:11814]
ENSG00000122783	77.38	76.53	81.08	66.54	75.10	70.59	0.16014717076624	5.26018817678601	0.0321850820649272	0.236678568526032	7:135092362-135170795:-	C7orf49	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus	NA	chromosome 7 open reading frame 49 [Source:HGNC Symbol%3BAcc:HGNC:22432]
ENSG00000110395	8.93	8.40	9.46	9.51	10.98	10.23	-0.182470751193178	4.79831286033093	0.0322529433887618	0.23703717364399	11:119206275-119313926:+	CBL	62;GO:0000209,biological_process protein polyubiquitination;GO:0001784,molecular_function phosphotyrosine binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0008584,biological_process male gonad development;GO:0010332,biological_process response to gamma radiation;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823,biological_process response to activity;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016600,cellular_component flotillin complex;GO:0016740,molecular_function transferase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019901,molecular_function protein kinase binding;GO:0023051,biological_process regulation of signaling;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0033574,biological_process response to testosterone;GO:0035635,biological_process entry of bacterium into host cell;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0036312,molecular_function phosphatidylinositol 3-kinase regulatory subunit binding;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042594,biological_process response to starvation;GO:0042629,cellular_component mast cell granule;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043303,biological_process mast cell degranulation;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0045471,biological_process response to ethanol;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0046677,biological_process response to antibiotic;GO:0046872,molecular_function metal ion binding;GO:0046875,molecular_function ephrin receptor binding;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061024,biological_process membrane organization;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070997,biological_process neuron death;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0090650,biological_process cellular response to oxygen-glucose deprivation;GO:1901215,biological_process negative regulation of neuron death;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990782,molecular_function protein tyrosine kinase binding	CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]; K04707	Cbl proto-oncogene [Source:HGNC Symbol%3BAcc:HGNC:1541]
ENSG00000076924	21.61	22.35	21.23	24.14	23.39	24.76	-0.139105406431443	5.88192025855511	0.0324869064892333	0.238252115460972	19:7619524-7629565:-	XAB2	21;GO:0000349,biological_process generation of catalytic spliceosome for first transesterification step;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0001824,biological_process blastocyst development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0021987,biological_process cerebral cortex development;GO:0071010,cellular_component prespliceosome;GO:0071012,cellular_component catalytic step 1 spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071014,cellular_component post-mRNA release spliceosomal complex	SYF1, XAB2; pre-mRNA-splicing factor SYF1; K12867	XPA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:14089]
ENSG00000154274	3.38	3.83	2.95	2.63	2.37	2.40	0.452920993631027	1.64133536658119	0.0325046188735193	0.238252115460972	4:37453940-37623495:+	C4orf19	3;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0030054,cellular_component cell junction	NA	chromosome 4 open reading frame 19 [Source:HGNC Symbol%3BAcc:HGNC:25618]
ENSG00000164587	1338.66	1249.68	1244.26	1441.99	1334.36	1465.21	-0.134404670972009	9.68911368180539	0.0325378141235571	0.238252115460972	5:150443189-150449756:-	RPS14	29;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030218,biological_process erythrocyte differentiation;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0045182,molecular_function translation regulator activity;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070062,cellular_component extracellular exosome;GO:0070181,molecular_function small ribosomal subunit rRNA binding	RP-S14e, RPS14; small subunit ribosomal protein S14e; K02955	ribosomal protein S14 [Source:HGNC Symbol%3BAcc:HGNC:10387]
ENSG00000166147	8.37	6.00	7.69	6.60	5.76	6.75	0.222581084881945	5.90385218037554	0.0325391736889592	0.238252115460972	15:48408305-48645849:-	FBN1	35;GO:0001501,biological_process skeletal system development;GO:0001527,cellular_component microfibril;GO:0001656,biological_process metanephros development;GO:0001822,biological_process kidney development;GO:0005178,molecular_function integrin binding;GO:0005179,molecular_function hormone activity;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007507,biological_process heart development;GO:0008201,molecular_function heparin binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030023,molecular_function extracellular matrix constituent conferring elasticity;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0032403,molecular_function protein complex binding;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0035582,biological_process sequestering of BMP in extracellular matrix;GO:0035583,biological_process sequestering of TGFbeta in extracellular matrix;GO:0043010,biological_process camera-type eye development;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0048048,biological_process embryonic eye morphogenesis;GO:0048050,biological_process post-embryonic eye morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090287,biological_process regulation of cellular response to growth factor stimulus;GO:1990314,biological_process cellular response to insulin-like growth factor stimulus;GO:2001205,biological_process negative regulation of osteoclast development	FBN1; fibrillin 1; K06825	fibrillin 1 [Source:HGNC Symbol%3BAcc:HGNC:3603]
ENSG00000163297	11.98	10.91	13.45	10.56	8.94	11.49	0.245222089917992	4.18458823968198	0.0325392509513332	0.238252115460972	4:79901148-80125454:-	ANTXR2	14;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022414,biological_process reproductive process;GO:0046872,molecular_function metal ion binding;GO:1901998,biological_process toxin transport	NA	anthrax toxin receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:21732]
ENSG00000105613	1.58	1.88	1.57	1.38	1.32	1.41	0.287193050345158	2.91423427690638	0.0325577626422441	0.238252115460972	19:12833950-12874951:+	MAST1	19;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007010,biological_process cytoskeleton organization;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	microtubule associated serine/threonine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:19034]
ENSG00000144451	12.79	12.29	11.77	14.39	13.39	13.87	-0.164471178336797	4.95590722346201	0.0325741985158448	0.238252115460972	2:213284378-214410501:+	SPAG16	15;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007288,biological_process sperm axoneme assembly;GO:0030030,biological_process cell projection organization;GO:0031514,cellular_component motile cilium;GO:0035082,biological_process axoneme assembly;GO:0042995,cellular_component cell projection;GO:0051012,biological_process microtubule sliding;GO:0060271,biological_process cilium morphogenesis;GO:0060294,biological_process cilium movement involved in cell motility;GO:0097231,biological_process cell motility in response to calcium ion;GO:1990716,cellular_component axonemal central apparatus	NA	sperm associated antigen 16 [Source:HGNC Symbol%3BAcc:HGNC:23225]
ENSG00000110080	14.56	14.22	16.12	12.81	14.14	11.85	0.22731144059127	4.04054716464222	0.0325873149003322	0.238252115460972	11:126355639-126440344:+	ST3GAL4	19;GO:0000139,cellular_component Golgi membrane;GO:0003836,molecular_function beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0032580,cellular_component Golgi cisterna membrane;GO:0047288,molecular_function monosialoganglioside sialyltransferase activity;GO:0050890,biological_process cognition;GO:0070062,cellular_component extracellular exosome;GO:0097503,biological_process sialylation	SIAT4C; beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4C) [EC:2.4.99.4]; K03494	ST3 beta-galactoside alpha-2%2C3-sialyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:10864]
ENSG00000213689	9.63	9.58	9.11	8.93	6.71	7.88	0.277970713146355	3.27784625555576	0.0325910007292944	0.238252115460972	3:48465810-48467645:+	TREX1	28;GO:0003676,molecular_function nucleic acid binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006259,biological_process DNA metabolic process;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006310,biological_process DNA recombination;GO:0008296,molecular_function 3'-5'-exodeoxyribonuclease activity;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0008853,molecular_function exodeoxyribonuclease III activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0032405,molecular_function MutLalpha complex binding;GO:0032407,molecular_function MutSalpha complex binding;GO:0032479,biological_process regulation of type I interferon production;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]; K10790	three prime repair exonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:12269]
ENSG00000161091	16.98	15.79	16.19	14.78	15.26	14.38	0.155272129019328	5.22731785700141	0.0326686590482893	0.238422317406393	19:3538260-3574290:-	MFSD12	4;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	major facilitator superfamily domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:28299]
ENSG00000120696	2.13	2.75	2.04	1.79	1.40	1.95	0.418911488466245	2.08317869227186	0.032682525937064	0.238422317406393	13:41189832-41194566:-	KBTBD7	10;GO:0000165,biological_process MAPK cascade;GO:0003674,molecular_function molecular_function;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification	NA	kelch repeat and BTB domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:25266]
ENSG00000112739	26.44	25.50	26.68	22.33	25.63	23.65	0.147593055132204	6.24476102865886	0.0326866317142619	0.238422317406393	6:4021266-4064983:+	PRPF4B	18;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005694,cellular_component chromosome;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0008380,biological_process RNA splicing;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	pre-mRNA processing factor 4B [Source:HGNC Symbol%3BAcc:HGNC:17346]
ENSG00000071994	40.51	42.26	45.96	44.67	49.74	51.06	-0.164820334952476	5.63293213551035	0.0326911128837252	0.238422317406393	6:170575294-170584692:-	PDCD2	13;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0012501,biological_process programmed cell death;GO:0019899,molecular_function enzyme binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1901532,biological_process regulation of hematopoietic progenitor cell differentiation;GO:1902035,biological_process positive regulation of hematopoietic stem cell proliferation	NA	programmed cell death 2 [Source:HGNC Symbol%3BAcc:HGNC:8762]
ENSG00000102967	11.09	11.75	11.00	13.25	13.61	12.67	-0.215615776215776	3.89563734870753	0.032812726029928	0.239168742342628	16:72008587-72027664:+	DHODH	29;GO:0003824,molecular_function catalytic activity;GO:0004152,molecular_function dihydroorotate dehydrogenase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006207,biological_process 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0007565,biological_process female pregnancy;GO:0007595,biological_process lactation;GO:0008144,molecular_function drug binding;GO:0010181,molecular_function FMN binding;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0031000,biological_process response to caffeine;GO:0042493,biological_process response to drug;GO:0042594,biological_process response to starvation;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0044205,biological_process 'de novo' UMP biosynthetic process;GO:0046134,biological_process pyrimidine nucleoside biosynthetic process;GO:0048039,molecular_function ubiquinone binding;GO:0055114,biological_process oxidation-reduction process;GO:0090140,biological_process regulation of mitochondrial fission;GO:1903576,biological_process response to L-arginine	DHODH, pyrD; dihydroorotate dehydrogenase [EC:1.3.5.2]; K00254	dihydroorotate dehydrogenase (quinone) [Source:HGNC Symbol%3BAcc:HGNC:2867]
ENSG00000112308	161.21	148.53	155.78	171.31	170.31	173.62	-0.133303650857388	6.90027256006636	0.032835405678432	0.239184112843413	6:24704860-24720836:-	C6orf62	3;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0008150,biological_process biological_process	NA	chromosome 6 open reading frame 62 [Source:HGNC Symbol%3BAcc:HGNC:20998]
ENSG00000138668	286.95	294.01	267.16	315.19	319.48	303.64	-0.134459183452028	8.35287780889749	0.0328533724641923	0.239184112843413	4:82352497-82374503:-	HNRNPD	51;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001889,biological_process liver development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003680,molecular_function AT DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0006401,biological_process RNA catabolic process;GO:0007420,biological_process brain development;GO:0008134,molecular_function transcription factor binding;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016070,biological_process RNA metabolic process;GO:0019013,cellular_component viral nucleocapsid;GO:0021549,biological_process cerebellum development;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032204,biological_process regulation of telomere maintenance;GO:0032355,biological_process response to estradiol;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0042162,molecular_function telomeric DNA binding;GO:0042493,biological_process response to drug;GO:0042752,biological_process regulation of circadian rhythm;GO:0042826,molecular_function histone deacetylase binding;GO:0043488,biological_process regulation of mRNA stability;GO:0045727,biological_process positive regulation of translation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048255,biological_process mRNA stabilization;GO:0048511,biological_process rhythmic process;GO:0051592,biological_process response to calcium ion;GO:0051602,biological_process response to electrical stimulus;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0070062,cellular_component extracellular exosome;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071732,biological_process cellular response to nitric oxide;GO:0097167,biological_process circadian regulation of translation;GO:1901355,biological_process response to rapamycin;GO:1904355,biological_process positive regulation of telomere capping;GO:1904383,biological_process response to sodium phosphate;GO:1904586,biological_process cellular response to putrescine;GO:1905663,biological_process positive regulation of telomerase RNA reverse transcriptase activity;GO:1990828,biological_process hepatocyte dedifferentiation	NA	heterogeneous nuclear ribonucleoprotein D [Source:HGNC Symbol%3BAcc:HGNC:5036]
ENSG00000153982	1.99	2.42	1.93	3.09	3.42	2.51	-0.50491313814542	1.52411901767151	0.0328838735144684	0.239265839352342	17:59220466-59275967:+	GDPD1	11;GO:0004622,molecular_function lysophospholipase activity;GO:0005737,cellular_component cytoplasm;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070291,biological_process N-acylethanolamine metabolic process	NA	glycerophosphodiester phosphodiesterase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20883]
ENSG00000002586	261.02	265.58	254.90	242.23	246.32	232.59	0.127519334201389	8.13092333710352	0.0329064196354635	0.239289623277685	X:2691178-2741309:+	CD99	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050776,biological_process regulation of immune response	CD99, MIC2; CD99 antigen; K06520	CD99 molecule (Xg blood group) [Source:HGNC Symbol%3BAcc:HGNC:7082]
ENSG00000182700	25.32	37.26	35.18	23.07	25.28	25.65	0.397432313256219	2.2194831147572	0.032975742863725	0.239653334992634	5:140125934-140129392:+	IGIP	1;GO:0005576,cellular_component extracellular region	NA	IgA inducing protein [Source:HGNC Symbol%3BAcc:HGNC:33847]
ENSG00000177707	27.26	26.09	26.72	23.64	26.22	22.94	0.150715827150049	5.91599674207342	0.0330148744489869	0.239668200706287	3:111070070-111275563:+	NECTIN3	28;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007286,biological_process spermatid development;GO:0008037,biological_process cell recognition;GO:0009566,biological_process fertilization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030054,cellular_component cell junction;GO:0034332,biological_process adherens junction organization;GO:0042803,molecular_function protein homodimerization activity;GO:0043296,cellular_component apical junction complex;GO:0044291,cellular_component cell-cell contact zone;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046982,molecular_function protein heterodimerization activity;GO:0050839,molecular_function cell adhesion molecule binding;GO:0060042,biological_process retina morphogenesis in camera-type eye;GO:1902414,biological_process protein localization to cell junction	PVRL3, CD113; poliovirus receptor-related protein 3; K06592	nectin cell adhesion molecule 3 [Source:HGNC Symbol%3BAcc:HGNC:17664]
ENSG00000084463	48.44	53.67	47.50	57.43	56.08	53.68	-0.150723269456941	6.66825319137159	0.0330333333112439	0.239668200706287	12:14784578-14803540:-	WBP11	21;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0050699,molecular_function WW domain binding;GO:0050790,biological_process regulation of catalytic activity;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	WBP11, NPWBP; WW domain-binding protein 11; K12866	WW domain binding protein 11 [Source:HGNC Symbol%3BAcc:HGNC:16461]
ENSG00000111885	35.98	36.49	35.69	29.12	34.96	33.63	0.157741293993437	6.07415329248273	0.0330357118672728	0.239668200706287	6:119177208-119349761:-	MAN1A1	17;GO:0000139,cellular_component Golgi membrane;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006486,biological_process protein glycosylation;GO:0006491,biological_process N-glycan processing;GO:0008152,biological_process metabolic process;GO:0015923,molecular_function mannosidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0070062,cellular_component extracellular exosome;GO:1904381,biological_process Golgi apparatus mannose trimming	MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]; K01230	mannosidase alpha class 1A member 1 [Source:HGNC Symbol%3BAcc:HGNC:6821]
ENSG00000035862	122.49	131.74	122.96	104.30	123.18	113.37	0.156666942232853	6.49581316155937	0.0330601261011064	0.239705225054342	17:78852976-78925387:-	TIMP2	39;GO:0002020,molecular_function protease binding;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0007417,biological_process central nervous system development;GO:0007568,biological_process aging;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009725,biological_process response to hormone;GO:0009986,cellular_component cell surface;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030426,cellular_component growth cone;GO:0031012,cellular_component extracellular matrix;GO:0032487,biological_process regulation of Rap protein signal transduction;GO:0034097,biological_process response to cytokine;GO:0035580,cellular_component specific granule lumen;GO:0042493,biological_process response to drug;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043312,biological_process neutrophil degranulation;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045762,biological_process positive regulation of adenylate cyclase activity;GO:0045861,biological_process negative regulation of proteolysis;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding;GO:0051045,biological_process negative regulation of membrane protein ectodomain proteolysis;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1905049,biological_process negative regulation of metallopeptidase activity	NA	TIMP metallopeptidase inhibitor 2 [Source:HGNC Symbol%3BAcc:HGNC:11821]
ENSG00000139269	4.27	2.80	4.18	5.97	3.47	6.89	-0.513596578784463	2.39324975295058	0.0331096545794878	0.239924192816802	12:57452322-57459280:+	INHBE	11;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0008083,molecular_function growth factor activity;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042981,biological_process regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0048468,biological_process cell development;GO:0060395,biological_process SMAD protein signal transduction	INHBA; inhibin beta A chain; K04667	inhibin beta E subunit [Source:HGNC Symbol%3BAcc:HGNC:24029]
ENSG00000122966	8.38	8.49	7.50	8.89	10.01	8.68	-0.167734528564011	5.76481861486932	0.0332514705952846	0.240811262835045	12:119685789-119877291:-	CIT	36;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000281,biological_process mitotic cytokinesis;GO:0000910,biological_process cytokinesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007030,biological_process Golgi organization;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008064,biological_process regulation of actin polymerization or depolymerization;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0017124,molecular_function SH3 domain binding;GO:0030154,biological_process cell differentiation;GO:0030165,molecular_function PDZ domain binding;GO:0031985,cellular_component Golgi cisterna;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035556,biological_process intracellular signal transduction;GO:0043025,cellular_component neuronal cell body;GO:0046872,molecular_function metal ion binding;GO:0048699,biological_process generation of neurons;GO:0051301,biological_process cell division;GO:0051402,biological_process neuron apoptotic process;GO:0097110,molecular_function scaffold protein binding	NA	citron rho-interacting serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:1985]
ENSG00000169330	1.26	1.35	0.77	0.92	0.61	0.79	0.538530215180914	1.45376418470359	0.03331478561457	0.240853850002212	15:79432515-79472290:+	KIAA1024	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	KIAA1024 [Source:HGNC Symbol%3BAcc:HGNC:29172]
ENSG00000099901	109.10	111.71	100.31	120.05	120.17	116.39	-0.140459728629995	7.03612615510378	0.0333330848090006	0.240853850002212	22:20115937-20127357:+	RANBP1	28;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006405,biological_process RNA export from nucleus;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006606,biological_process protein import into nucleus;GO:0007051,biological_process spindle organization;GO:0007165,biological_process signal transduction;GO:0008536,molecular_function Ran GTPase binding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016032,biological_process viral process;GO:0032838,cellular_component cell projection cytoplasm;GO:0035690,biological_process cellular response to drug;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0046604,biological_process positive regulation of mitotic centrosome separation;GO:0046907,biological_process intracellular transport;GO:0050790,biological_process regulation of catalytic activity;GO:0051592,biological_process response to calcium ion;GO:0072750,biological_process cellular response to leptomycin B;GO:1904115,cellular_component axon cytoplasm	RANBP1; Ran-binding protein 1; K15306	RAN binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9847]
ENSG00000167515	28.73	31.53	29.94	32.07	37.77	33.29	-0.184182181569157	4.98207606495814	0.0333533162193584	0.240853850002212	16:88856219-88862686:+	TRAPPC2L	18;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051259,biological_process protein oligomerization;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 2 like [Source:HGNC Symbol%3BAcc:HGNC:30887]
ENSG00000178913	92.48	93.74	93.57	104.84	97.28	108.80	-0.14098498388741	6.69098512428944	0.0333665990110834	0.240853850002212	5:141260224-141320821:-	TAF7	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000296,biological_process spermine transport;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0008134,molecular_function transcription factor binding;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0033276,cellular_component transcription factor TFTC complex;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035067,biological_process negative regulation of histone acetylation;GO:0042809,molecular_function vitamin D receptor binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:0060260,biological_process regulation of transcription initiation from RNA polymerase II promoter;GO:0061628,molecular_function H3K27me3 modified histone binding;GO:0071339,cellular_component MLL1 complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF7; transcription initiation factor TFIID subunit 7; K03132	TATA-box binding protein associated factor 7 [Source:HGNC Symbol%3BAcc:HGNC:11541]
ENSG00000126602	49.55	50.07	47.95	57.71	52.12	54.11	-0.14049706147603	6.84642475108209	0.033374167378121	0.240853850002212	16:3651638-3717597:-	TRAP1	22;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005811,cellular_component lipid particle;GO:0006457,biological_process protein folding;GO:0006950,biological_process response to stress;GO:0009386,biological_process translational attenuation;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:1901856,biological_process negative regulation of cellular respiration;GO:1903427,biological_process negative regulation of reactive oxygen species biosynthetic process;GO:1903751,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	NA	TNF receptor associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16264]
ENSG00000105443	44.80	44.77	43.09	41.00	40.39	40.53	0.133088271711188	6.39772691339774	0.0333962097099247	0.240853850002212	19:48469031-48482314:+	CYTH2	16;GO:0000139,cellular_component Golgi membrane;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030426,cellular_component growth cone;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070679,molecular_function inositol 1,4,5 trisphosphate binding	NA	cytohesin 2 [Source:HGNC Symbol%3BAcc:HGNC:9502]
ENSG00000144161	12.72	13.90	14.49	16.92	15.02	16.67	-0.233227734251137	3.75966497946181	0.0334009024565303	0.240853850002212	2:112211524-112255136:-	ZC3H8	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001162,molecular_function RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0008023,cellular_component transcription elongation factor complex;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0033085,biological_process negative regulation of T cell differentiation in thymus;GO:0035327,cellular_component transcriptionally active chromatin;GO:0035363,cellular_component histone locus body;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042796,biological_process snRNA transcription from RNA polymerase III promoter;GO:0043029,biological_process T cell homeostasis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0046677,biological_process response to antibiotic;GO:0046872,molecular_function metal ion binding;GO:0070245,biological_process positive regulation of thymocyte apoptotic process	NA	zinc finger CCCH-type containing 8 [Source:HGNC Symbol%3BAcc:HGNC:30941]
ENSG00000278845	45.01	49.76	50.51	54.65	51.06	58.06	-0.163758120841929	5.56916877419801	0.0334310472574837	0.240853850002212	17:38297022-38323218:+	MRPL45	1;GO:0005739,cellular_component mitochondrion	NA	mitochondrial ribosomal protein L45 [Source:HGNC Symbol%3BAcc:HGNC:16651]
ENSG00000187257	11.99	12.05	13.34	11.56	11.33	10.50	0.177175668153786	4.91125990468362	0.0334756112379811	0.240853850002212	7:77696442-77783022:+	RSBN1L	1;GO:0005634,cellular_component nucleus	NA	round spermatid basic protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:24765]
ENSG00000164136	27.15	23.57	25.15	31.40	26.07	33.73	-0.249926784391634	3.86461791704228	0.033476900545407	0.240853850002212	4:141636598-141733987:+	IL15	44;GO:0001779,biological_process natural killer cell differentiation;GO:0001866,biological_process NK T cell proliferation;GO:0005125,molecular_function cytokine activity;GO:0005126,molecular_function cytokine receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007260,biological_process tyrosine phosphorylation of STAT protein;GO:0007267,biological_process cell-cell signaling;GO:0007568,biological_process aging;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0014732,biological_process skeletal muscle atrophy;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030212,biological_process hyaluronan metabolic process;GO:0031667,biological_process response to nutrient levels;GO:0032740,biological_process positive regulation of interleukin-17 production;GO:0032819,biological_process positive regulation of natural killer cell proliferation;GO:0032825,biological_process positive regulation of natural killer cell differentiation;GO:0034105,biological_process positive regulation of tissue remodeling;GO:0035723,biological_process interleukin-15-mediated signaling pathway;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0045062,biological_process extrathymic T cell selection;GO:0045580,biological_process regulation of T cell differentiation;GO:0048469,biological_process cell maturation;GO:0048535,biological_process lymph node development;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050691,biological_process regulation of defense response to virus by host;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050778,biological_process positive regulation of immune response;GO:0071305,biological_process cellular response to vitamin D;GO:1904100,biological_process positive regulation of protein O-linked glycosylation	IL15; interleukin 15; K05433	interleukin 15 [Source:HGNC Symbol%3BAcc:HGNC:5977]
ENSG00000140538	4.20	5.74	4.08	3.93	4.18	3.13	0.321953771334023	3.66638103792973	0.0334772200896904	0.240853850002212	15:87859750-88256768:-	NTRK3	56;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001764,biological_process neuron migration;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005004,molecular_function GPI-linked ephrin receptor activity;GO:0005030,molecular_function neurotrophin receptor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007507,biological_process heart development;GO:0007623,biological_process circadian rhythm;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019056,biological_process modulation by virus of host transcription;GO:0030154,biological_process cell differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0032148,biological_process activation of protein kinase B activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0038179,biological_process neurotrophin signaling pathway;GO:0042490,biological_process mechanoreceptor differentiation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043121,molecular_function neurotrophin binding;GO:0043235,cellular_component receptor complex;GO:0045471,biological_process response to ethanol;GO:0046777,biological_process protein autophosphorylation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048665,biological_process neuron fate specification;GO:0048678,biological_process response to axon injury;GO:0048691,biological_process positive regulation of axon extension involved in regeneration;GO:0048712,biological_process negative regulation of astrocyte differentiation;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0051412,biological_process response to corticosterone;GO:0051965,biological_process positive regulation of synapse assembly;GO:0060548,biological_process negative regulation of cell death;GO:0070306,biological_process lens fiber cell differentiation;GO:0071300,biological_process cellular response to retinoic acid;GO:0090102,biological_process cochlea development;GO:0090630,biological_process activation of GTPase activity;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization	NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]; K05101	neurotrophic receptor tyrosine kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:8033]
ENSG00000184675	1.57	1.55	1.77	1.28	1.32	1.30	0.342706390121181	2.3807486726608	0.0334901913400321	0.240853850002212	X:64185116-64205744:-	AMER1	26;GO:0001822,biological_process kidney development;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008013,molecular_function beta-catenin binding;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016604,cellular_component nuclear body;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048856,biological_process anatomical structure development;GO:0060348,biological_process bone development;GO:0060612,biological_process adipose tissue development;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0072161,biological_process mesenchymal cell differentiation involved in kidney development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:1904713,molecular_function beta-catenin destruction complex binding;GO:1904885,biological_process beta-catenin destruction complex assembly;GO:1904886,biological_process beta-catenin destruction complex disassembly	NA	APC membrane recruitment protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26837]
ENSG00000166788	15.94	17.30	13.58	19.10	17.44	17.89	-0.211917520479999	4.60212928915213	0.0335563669683094	0.241190030791908	11:18069934-18106091:-	SAAL1	2;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space	NA	serum amyloid A like 1 [Source:HGNC Symbol%3BAcc:HGNC:25158]
ENSG00000135976	5.56	4.69	5.44	4.95	4.24	4.69	0.194813419134785	4.90409848492351	0.0336137910802414	0.241462956411479	2:97113495-97264521:+	ANKRD36	NA	NA	ankyrin repeat domain 36 [Source:HGNC Symbol%3BAcc:HGNC:24079]
ENSG00000171992	106.20	101.93	108.75	118.98	110.64	120.26	-0.13081486064875	8.5916990261006	0.0336917294971906	0.241720508898738	5:150601079-150659220:+	SYNPO	23;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0008542,biological_process visual learning;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043204,cellular_component perikaryon;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0097444,cellular_component spine apparatus;GO:0098886,biological_process modification of dendritic spine;GO:1905355,biological_process spine apparatus assembly	NA	synaptopodin [Source:HGNC Symbol%3BAcc:HGNC:30672]
ENSG00000102181	57.81	49.50	54.44	48.85	45.84	51.59	0.159753531255985	5.91191960078457	0.0336995902637747	0.241720508898738	X:150766336-150898816:-	CD99L2	7;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction	NA	CD99 molecule like 2 [Source:HGNC Symbol%3BAcc:HGNC:18237]
ENSG00000186063	99.40	101.08	104.15	119.65	108.39	110.92	-0.142265917530641	6.62509822768959	0.0337080641991232	0.241720508898738	1:222668012-222713210:-	AIDA	12;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043496,biological_process regulation of protein homodimerization activity;GO:0043508,biological_process negative regulation of JUN kinase activity;GO:0046329,biological_process negative regulation of JNK cascade;GO:0048264,biological_process determination of ventral identity	NA	axin interactor%2C dorsalization associated [Source:HGNC Symbol%3BAcc:HGNC:25761]
ENSG00000188626	1.49	1.01	1.09	0.55	0.80	1.04	0.602774062997251	1.03648237888648	0.0337383798902505	0.241798215691501	15:28701953-28738384:-	GOLGA8M	1;GO:0005794,cellular_component Golgi apparatus	NA	NA
ENSG00000198185	4.08	2.49	2.84	4.71	3.28	4.68	-0.405323691202002	3.02757068882228	0.0338014773698423	0.242110639695241	20:46499629-46513559:-	ZNF334	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 334 [Source:HGNC Symbol%3BAcc:HGNC:15806]
ENSG00000124374	6.12	7.25	6.78	9.94	9.04	8.77	-0.456936714659883	1.63373339506777	0.0338238266759178	0.242131003764802	2:71182738-71227083:-	PAIP2B	5;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006417,biological_process regulation of translation;GO:0045947,biological_process negative regulation of translational initiation	NA	poly(A) binding protein interacting protein 2B [Source:HGNC Symbol%3BAcc:HGNC:29200]
ENSG00000203760	51.43	49.79	48.83	55.25	63.32	56.21	-0.206605458978674	4.07988711287829	0.0338553263678674	0.242216810492414	6:126340173-126348875:+	CENPW	18;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0016363,cellular_component nuclear matrix;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0046982,molecular_function protein heterodimerization activity;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0051382,biological_process kinetochore assembly	NA	centromere protein W [Source:HGNC Symbol%3BAcc:HGNC:21488]
ENSG00000065526	10.79	10.87	10.84	10.26	9.78	9.88	0.13105870923875	6.87657423787981	0.0339465354291943	0.242616866405555	1:15847863-15940460:+	SPEN	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001191,molecular_function transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007219,biological_process Notch signaling pathway;GO:0016032,biological_process viral process;GO:0017053,cellular_component transcriptional repressor complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0050769,biological_process positive regulation of neurogenesis;GO:0070062,cellular_component extracellular exosome	NA	spen family transcriptional repressor [Source:HGNC Symbol%3BAcc:HGNC:17575]
ENSG00000162493	1.54	0.37	1.42	0.38	0.49	0.81	1.03098127621625	-0.281437421554725	0.0339503340809192	0.242616866405555	1:13583464-13617957:+	PDPN	53;GO:0000902,biological_process cell morphogenesis;GO:0001726,cellular_component ruffle;GO:0001946,biological_process lymphangiogenesis;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006693,biological_process prostaglandin metabolic process;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009897,cellular_component external side of plasma membrane;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019956,molecular_function chemokine binding;GO:0030027,cellular_component lamellipodium;GO:0030155,biological_process regulation of cell adhesion;GO:0030168,biological_process platelet activation;GO:0030175,cellular_component filopodium;GO:0030324,biological_process lung development;GO:0030335,biological_process positive regulation of cell migration;GO:0031258,cellular_component lamellipodium membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031527,cellular_component filopodium membrane;GO:0031528,cellular_component microvillus membrane;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044319,biological_process wound healing, spreading of cells;GO:0045121,cellular_component membrane raft;GO:0048286,biological_process lung alveolus development;GO:0048535,biological_process lymph node development;GO:0051087,molecular_function chaperone binding;GO:0051272,biological_process positive regulation of cellular component movement;GO:0060838,biological_process lymphatic endothelial cell fate commitment;GO:0061851,cellular_component leading edge of lamellipodium;GO:0071437,cellular_component invadopodium;GO:0090091,biological_process positive regulation of extracellular matrix disassembly;GO:0097197,cellular_component tetraspanin-enriched microdomain;GO:1900024,biological_process regulation of substrate adhesion-dependent cell spreading;GO:1901731,biological_process positive regulation of platelet aggregation;GO:1904328,biological_process regulation of myofibroblast contraction;GO:1905863,biological_process invadopodium organization;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle;GO:2000392,biological_process regulation of lamellipodium morphogenesis	NA	podoplanin [Source:HGNC Symbol%3BAcc:HGNC:29602]
ENSG00000188092	2.80	3.19	3.28	4.43	4.80	3.13	-0.402394851309041	2.41530655762845	0.0340253458303664	0.242882805949023	1:147928392-147993521:+	GPR89B	13;GO:0000139,cellular_component Golgi membrane;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008308,molecular_function voltage-gated anion channel activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032580,cellular_component Golgi cisterna membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0051452,biological_process intracellular pH reduction;GO:1903959,biological_process regulation of anion transmembrane transport	NA	G protein-coupled receptor 89B [Source:HGNC Symbol%3BAcc:HGNC:13840]
ENSG00000142619	0.74	0.91	0.85	1.01	1.22	1.48	-0.569827176744331	1.15604005468766	0.0340266816680376	0.242882805949023	1:17249097-17284233:+	PADI3	10;GO:0004668,molecular_function protein-arginine deiminase activity;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0016787,molecular_function hydrolase activity;GO:0018101,biological_process protein citrullination;GO:0036414,biological_process histone citrullination;GO:0042802,molecular_function identical protein binding	NA	peptidyl arginine deiminase 3 [Source:HGNC Symbol%3BAcc:HGNC:18337]
ENSG00000179526	43.25	45.44	45.71	39.08	42.46	40.94	0.144530766639836	5.63948020975448	0.0340932698737592	0.243218252266077	8:144098632-144108124:-	SHARPIN	26;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007005,biological_process mitochondrion organization;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007420,biological_process brain development;GO:0008544,biological_process epidermis development;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0014069,cellular_component postsynaptic density;GO:0030054,cellular_component cell junction;GO:0030262,biological_process apoptotic nuclear changes;GO:0030425,cellular_component dendrite;GO:0031424,biological_process keratinization;GO:0031593,molecular_function polyubiquitin binding;GO:0032403,molecular_function protein complex binding;GO:0042802,molecular_function identical protein binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051260,biological_process protein homooligomerization;GO:0071797,cellular_component LUBAC complex;GO:0097039,biological_process protein linear polyubiquitination;GO:2000348,biological_process regulation of CD40 signaling pathway	NA	SHANK associated RH domain interactor [Source:HGNC Symbol%3BAcc:HGNC:25321]
ENSG00000176986	30.17	30.49	29.89	27.36	29.11	26.38	0.139684341468175	6.63078646454613	0.0341493169047947	0.243478156656643	10:73744383-73772161:+	SEC24C	24;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0001701,biological_process in utero embryonic development;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008270,molecular_function zinc ion binding;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030127,cellular_component COPII vesicle coat;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090110,biological_process cargo loading into COPII-coated vesicle	SEC24; protein transport protein SEC24; K14007	SEC24 homolog C%2C COPII coat complex component [Source:HGNC Symbol%3BAcc:HGNC:10705]
ENSG00000121281	7.49	7.36	8.74	9.01	8.45	9.77	-0.192278597415473	4.84944086411299	0.0342408926380824	0.243990930147254	16:50246136-50318135:+	ADCY7	29;GO:0000166,molecular_function nucleotide binding;GO:0003091,biological_process renal water homeostasis;GO:0004016,molecular_function adenylate cyclase activity;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0004383,molecular_function guanylate cyclase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006171,biological_process cAMP biosynthetic process;GO:0006182,biological_process cGMP biosynthetic process;GO:0007165,biological_process signal transduction;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0022904,biological_process respiratory electron transport chain;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0034199,biological_process activation of protein kinase A activity;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0071361,biological_process cellular response to ethanol;GO:0071377,biological_process cellular response to glucagon stimulus;GO:1902600,biological_process hydrogen ion transmembrane transport	ADCY7; adenylate cyclase 7 [EC:4.6.1.1]; K08047	adenylate cyclase 7 [Source:HGNC Symbol%3BAcc:HGNC:238]
ENSG00000181004	5.01	4.26	3.87	5.91	5.45	4.85	-0.285623702112821	3.40660701559337	0.0342861856373496	0.244173506779358	4:122732701-122744943:+	BBS12	14;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005929,cellular_component cilium;GO:0006458,biological_process 'de novo' protein folding;GO:0042073,biological_process intraciliary transport;GO:0042755,biological_process eating behavior;GO:0042995,cellular_component cell projection;GO:0044183,molecular_function protein binding involved in protein folding;GO:0045494,biological_process photoreceptor cell maintenance;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0051082,molecular_function unfolded protein binding;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0061077,biological_process chaperone-mediated protein folding	NA	Bardet-Biedl syndrome 12 [Source:HGNC Symbol%3BAcc:HGNC:26648]
ENSG00000135336	23.28	21.16	22.29	26.01	24.18	24.43	-0.146124141446005	5.6600576034037	0.0343181310805549	0.244260872192046	6:87590066-87667453:+	ORC3	16;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000808,cellular_component origin recognition complex;GO:0003677,molecular_function DNA binding;GO:0003688,molecular_function DNA replication origin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005656,cellular_component nuclear pre-replicative complex;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0006260,biological_process DNA replication;GO:0006267,biological_process pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0016604,cellular_component nuclear body;GO:0031261,cellular_component DNA replication preinitiation complex;GO:0061351,biological_process neural precursor cell proliferation	ORC3; origin recognition complex subunit 3; K02605	origin recognition complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:8489]
ENSG00000205476	4.00	4.26	3.91	4.35	5.42	5.58	-0.328708601683393	2.73255913397897	0.0343824931047064	0.244410706453155	14:99500179-99604026:-	CCDC85C	5;GO:0005923,cellular_component bicellular tight junction;GO:0007275,biological_process multicellular organism development;GO:0021987,biological_process cerebral cortex development;GO:0030054,cellular_component cell junction;GO:0043296,cellular_component apical junction complex	NA	coiled-coil domain containing 85C [Source:HGNC Symbol%3BAcc:HGNC:35459]
ENSG00000165923	1.01	1.11	1.40	0.97	0.77	0.81	0.474438577105777	1.64044259347608	0.0343982264119235	0.244410706453155	11:47659590-47715389:-	AGBL2	15;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0035610,biological_process protein side chain deglutamylation;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding	NA	ATP/GTP binding protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:26296]
ENSG00000111615	28.79	31.10	29.88	32.16	33.51	35.07	-0.158332631930474	5.18861392496242	0.0344152786468026	0.244410706453155	12:75490860-75511636:-	KRR1	14;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis;GO:0045171,cellular_component intercellular bridge	NA	KRR1%2C small subunit processome component homolog [Source:HGNC Symbol%3BAcc:HGNC:5176]
ENSG00000129925	14.81	16.51	15.10	13.00	14.92	13.57	0.170110259814275	5.12709909179983	0.0344179420671969	0.244410706453155	16:370772-387113:-	TMEM8A	10;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	transmembrane protein 8A [Source:HGNC Symbol%3BAcc:HGNC:17205]
ENSG00000168795	11.72	12.61	11.92	10.29	11.13	10.84	0.176486757645219	4.54243302368631	0.034439135731533	0.244421378979713	9:37438113-37465399:-	ZBTB5	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:23836]
ENSG00000213949	8.39	7.86	8.49	7.15	7.72	7.36	0.169840135871197	4.80009447137475	0.0345095498536047	0.244744267981734	5:52787895-52959210:+	ITGA1	35;GO:0000187,biological_process activation of MAPK activity;GO:0001669,cellular_component acrosomal vesicle;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006936,biological_process muscle contraction;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019903,molecular_function protein phosphatase binding;GO:0030198,biological_process extracellular matrix organization;GO:0030593,biological_process neutrophil chemotaxis;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0034665,cellular_component integrin alpha1-beta1 complex;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042311,biological_process vasodilation;GO:0043005,cellular_component neuron projection;GO:0043204,cellular_component perikaryon;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045121,cellular_component membrane raft;GO:0045123,biological_process cellular extravasation;GO:0045178,cellular_component basal part of cell;GO:0046872,molecular_function metal ion binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0060326,biological_process cell chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:0098639,molecular_function collagen binding involved in cell-matrix adhesion	ITGA1, CD49a; integrin alpha 1; K06480	integrin subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:6134]
ENSG00000117114	32.11	35.37	31.41	28.30	31.23	30.41	0.147126463375617	7.16433226881036	0.0345240645481363	0.244744267981734	1:81306159-81992436:+	ADGRL2	10;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016524,molecular_function latrotoxin receptor activity;GO:0030246,molecular_function carbohydrate binding	NA	adhesion G protein-coupled receptor L2 [Source:HGNC Symbol%3BAcc:HGNC:18582]
ENSG00000168758	16.79	15.68	15.58	14.26	15.36	13.82	0.159783789949578	5.25786872067472	0.0345591526767179	0.244853174758047	2:96859715-96870757:-	SEMA4C	21;GO:0001843,biological_process neural tube closure;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021535,biological_process cell migration in hindbrain;GO:0021549,biological_process cerebellum development;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0042692,biological_process muscle cell differentiation;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0050919,biological_process negative chemotaxis;GO:0071526,biological_process semaphorin-plexin signaling pathway	SEMA4, CD100; semaphorin 4; K06521	semaphorin 4C [Source:HGNC Symbol%3BAcc:HGNC:10731]
ENSG00000166444	27.40	28.11	25.93	23.53	26.54	23.99	0.148269559845389	6.67733111742345	0.0346073123862637	0.244912451216594	11:8693350-8910951:-	ST5	3;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity	NA	suppression of tumorigenicity 5 [Source:HGNC Symbol%3BAcc:HGNC:11350]
ENSG00000174899	8.04	9.84	7.12	6.54	7.34	4.83	0.420886308302662	2.25137170295083	0.0346123267800891	0.244912451216594	3:157543245-157677749:+	PQLC2L	NA	NA	PQ loop repeat containing 2 like [Source:HGNC Symbol%3BAcc:HGNC:25146]
ENSG00000184368	28.51	31.48	27.52	24.25	29.43	23.92	0.183263587712184	5.99758554262223	0.0346267100527771	0.244912451216594	X:20006712-20116917:-	MAP7D2	3;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005198,molecular_function structural molecule activity;GO:0015630,cellular_component microtubule cytoskeleton	NA	MAP7 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25899]
ENSG00000111602	10.09	12.79	9.87	12.40	13.44	12.09	-0.205937759191763	5.41866402794191	0.0346795189772019	0.245146280788159	12:56416372-56449403:-	TIMELESS	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0002009,biological_process morphogenesis of an epithelium;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007623,biological_process circadian rhythm;GO:0009582,biological_process detection of abiotic stimulus;GO:0009628,biological_process response to abiotic stimulus;GO:0030324,biological_process lung development;GO:0042752,biological_process regulation of circadian rhythm;GO:0042803,molecular_function protein homodimerization activity;GO:0044770,biological_process cell cycle phase transition;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0048511,biological_process rhythmic process;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0051301,biological_process cell division;GO:0072711,biological_process cellular response to hydroxyurea;GO:0072719,biological_process cellular response to cisplatin;GO:1904976,biological_process cellular response to bleomycin;GO:2000781,biological_process positive regulation of double-strand break repair	NA	timeless circadian clock [Source:HGNC Symbol%3BAcc:HGNC:11813]
ENSG00000124496	1.47	1.97	1.83	1.38	1.50	1.26	0.352096642380319	2.55827525408371	0.0347809669686473	0.245681358156892	6:42224930-42452051:-	TRERF1	24;GO:0000118,cellular_component histone deacetylase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006694,biological_process steroid biosynthetic process;GO:0006707,biological_process cholesterol catabolic process;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0008301,molecular_function DNA binding, bending;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0042592,biological_process homeostatic process;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046885,biological_process regulation of hormone biosynthetic process	NA	transcriptional regulating factor 1 [Source:HGNC Symbol%3BAcc:HGNC:18273]
ENSG00000185591	17.21	15.99	17.91	19.20	18.49	19.65	-0.150594890439099	5.4199909874598	0.0347947980053023	0.245681358156892	12:53380175-53416446:+	SP1	41;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0017053,cellular_component transcriptional repressor complex;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032993,cellular_component protein-DNA complex;GO:0035035,molecular_function histone acetyltransferase binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0070491,molecular_function repressing transcription factor binding;GO:0071837,molecular_function HMG box domain binding;GO:0100057,biological_process regulation of phenotypic switching by transcription from RNA polymerase II promoter;GO:1904828,biological_process positive regulation of hydrogen sulfide biosynthetic process	SP1; transcription factor Sp1; K04684	Sp1 transcription factor [Source:HGNC Symbol%3BAcc:HGNC:11205]
ENSG00000121289	9.16	8.03	10.13	11.39	10.82	9.68	-0.204290276922925	4.78099376688672	0.0349213655824773	0.246424938318819	19:32875924-32971991:-	CEP89	20;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007005,biological_process mitochondrion organization;GO:0007268,biological_process chemical synaptic transmission;GO:0030030,biological_process cell projection organization;GO:0031514,cellular_component motile cilium;GO:0060271,biological_process cilium morphogenesis;GO:0097539,cellular_component ciliary transition fiber;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0097730,cellular_component non-motile cilium;GO:1905515,biological_process non-motile cilium assembly	NA	centrosomal protein 89 [Source:HGNC Symbol%3BAcc:HGNC:25907]
ENSG00000136238	320.44	294.09	296.85	360.17	315.47	340.70	-0.145082091905775	7.67033051101206	0.0349850322215388	0.246424938318819	7:6374522-6403977:+	RAC1	86;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002551,biological_process mast cell chemotaxis;GO:0003924,molecular_function GTPase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006928,biological_process movement of cell or subcellular component;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007596,biological_process blood coagulation;GO:0008283,biological_process cell proliferation;GO:0008361,biological_process regulation of cell size;GO:0009611,biological_process response to wounding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010310,biological_process regulation of hydrogen peroxide metabolic process;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016601,biological_process Rac protein signal transduction;GO:0017137,molecular_function Rab GTPase binding;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030041,biological_process actin filament polymerization;GO:0030168,biological_process platelet activation;GO:0030334,biological_process regulation of cell migration;GO:0030667,cellular_component secretory granule membrane;GO:0031012,cellular_component extracellular matrix;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031295,biological_process T cell costimulation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031529,biological_process ruffle organization;GO:0031996,molecular_function thioesterase binding;GO:0032707,biological_process negative regulation of interleukin-23 production;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042470,cellular_component melanosome;GO:0042826,molecular_function histone deacetylase binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0043312,biological_process neutrophil degranulation;GO:0045453,biological_process bone resorption;GO:0045740,biological_process positive regulation of DNA replication;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048012,biological_process hepatocyte growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048261,biological_process negative regulation of receptor-mediated endocytosis;GO:0048870,biological_process cell motility;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0051022,molecular_function Rho GDP-dissociation inhibitor binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051117,molecular_function ATPase binding;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051668,biological_process localization within membrane;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060263,biological_process regulation of respiratory burst;GO:0070062,cellular_component extracellular exosome;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	RAC1; Ras-related C3 botulinum toxin substrate 1; K04392	ras-related C3 botulinum toxin substrate 1 (rho family%2C small GTP binding protein Rac1) [Source:HGNC Symbol%3BAcc:HGNC:9801]
ENSG00000278053	28.60	28.12	28.34	30.68	30.71	32.96	-0.137978937584215	5.79707144178506	0.0350051711693214	0.246424938318819	17:37609738-37643464:-	DDX52	14;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity	NA	DExD-box helicase 52 [Source:HGNC Symbol%3BAcc:HGNC:20038]
ENSG00000137501	30.23	35.37	28.24	33.75	39.13	34.55	-0.184373147936323	7.83805513831217	0.0350062999459558	0.246424938318819	11:85694223-85811159:-	SYTL2	25;GO:0001786,molecular_function phosphatidylserine binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006906,biological_process vesicle fusion;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017137,molecular_function Rab GTPase binding;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0019902,molecular_function phosphatase binding;GO:0019905,molecular_function syntaxin binding;GO:0030276,molecular_function clathrin binding;GO:0042043,molecular_function neurexin family protein binding;GO:0042470,cellular_component melanosome;GO:0070257,biological_process positive regulation of mucus secretion;GO:0070382,cellular_component exocytic vesicle;GO:0072659,biological_process protein localization to plasma membrane	NA	synaptotagmin like 2 [Source:HGNC Symbol%3BAcc:HGNC:15585]
ENSG00000169682	31.39	34.63	32.34	27.43	31.95	29.55	0.154754057845963	5.95721974444397	0.035018141739811	0.246424938318819	16:28974220-28984548:+	SPNS1	13;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031982,cellular_component vesicle;GO:0040011,biological_process locomotion;GO:0046624,molecular_function sphingolipid transporter activity;GO:0055085,biological_process transmembrane transport	NA	sphingolipid transporter 1 (putative) [Source:HGNC Symbol%3BAcc:HGNC:30621]
ENSG00000145220	12.24	14.20	16.05	18.70	15.34	16.82	-0.249130107685886	4.15983343890186	0.0350192210742283	0.246424938318819	4:4267700-4290169:-	LYAR	6;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0046872,molecular_function metal ion binding	NA	Ly1 antibody reactive [Source:HGNC Symbol%3BAcc:HGNC:26021]
ENSG00000186111	8.05	8.29	7.87	7.47	7.41	6.13	0.216592927650637	4.17716436157124	0.0350449100536397	0.246457139427723	19:3630182-3700479:-	PIP5K1C	43;GO:0000166,molecular_function nucleotide binding;GO:0001891,cellular_component phagocytic cup;GO:0001931,cellular_component uropod;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006887,biological_process exocytosis;GO:0006897,biological_process endocytosis;GO:0006909,biological_process phagocytosis;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0012505,cellular_component endomembrane system;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016301,molecular_function kinase activity;GO:0016307,molecular_function phosphatidylinositol phosphate kinase activity;GO:0016308,molecular_function 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016740,molecular_function transferase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030593,biological_process neutrophil chemotaxis;GO:0032587,cellular_component ruffle membrane;GO:0034333,biological_process adherens junction assembly;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0052811,molecular_function 1-phosphatidylinositol-3-phosphate 4-kinase activity;GO:0052812,molecular_function phosphatidylinositol-3,4-bisphosphate 5-kinase activity;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0098793,cellular_component presynapse	PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]; K00889	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [Source:HGNC Symbol%3BAcc:HGNC:8996]
ENSG00000065060	10.28	10.46	12.04	11.38	12.44	13.55	-0.176752550107494	5.66622330446127	0.0350635066647353	0.246457139427723	6:34792014-34883138:+	UHRF1BP1	3;GO:0005515,molecular_function protein binding;GO:0042802,molecular_function identical protein binding;GO:0042826,molecular_function histone deacetylase binding	NA	UHRF1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21216]
ENSG00000141522	159.39	185.29	162.23	154.53	152.68	153.67	0.147517134920463	7.42300564749539	0.0352297637314154	0.247485601130764	17:81867720-81871406:-	ARHGDIA	33;GO:0001772,cellular_component immunological synapse;GO:0005094,molecular_function Rho GDP-dissociation inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005504,molecular_function fatty acid binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006928,biological_process movement of cell or subcellular component;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007266,biological_process Rho protein signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0017048,molecular_function Rho GTPase binding;GO:0019901,molecular_function protein kinase binding;GO:0030336,biological_process negative regulation of cell migration;GO:0032880,biological_process regulation of protein localization;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050790,biological_process regulation of catalytic activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051879,molecular_function Hsp90 protein binding;GO:0070062,cellular_component extracellular exosome;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071461,biological_process cellular response to redox state;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	ARHGDI, RHOGDI; Rho GDP-dissociation inhibitor; K12462	Rho GDP dissociation inhibitor alpha [Source:HGNC Symbol%3BAcc:HGNC:678]
ENSG00000164708	29.68	28.71	29.67	26.83	26.48	25.20	0.180028217641431	4.40744414673884	0.0354433070720045	0.248753385009982	7:44062726-44065587:-	PGAM2	21;GO:0003824,molecular_function catalytic activity;GO:0004082,molecular_function bisphosphoglycerate mutase activity;GO:0004619,molecular_function phosphoglycerate mutase activity;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0006941,biological_process striated muscle contraction;GO:0007219,biological_process Notch signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0008152,biological_process metabolic process;GO:0010035,biological_process response to inorganic substance;GO:0016787,molecular_function hydrolase activity;GO:0016853,molecular_function isomerase activity;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0043456,biological_process regulation of pentose-phosphate shunt;GO:0046538,molecular_function 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0046689,biological_process response to mercury ion;GO:0048037,molecular_function cofactor binding;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome	PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]; K01834	phosphoglycerate mutase 2 [Source:HGNC Symbol%3BAcc:HGNC:8889]
ENSG00000182704	52.49	48.64	50.87	43.41	50.13	43.89	0.159693941792883	5.67996186642681	0.0354503132266702	0.248753385009982	11:76782250-76798154:+	TSKU	12;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0010468,biological_process regulation of gene expression;GO:0021540,biological_process corpus callosum morphogenesis;GO:0021670,biological_process lateral ventricle development;GO:0021960,biological_process anterior commissure morphogenesis;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0043010,biological_process camera-type eye development;GO:0061073,biological_process ciliary body morphogenesis	NA	tsukushi%2C small leucine rich proteoglycan [Source:HGNC Symbol%3BAcc:HGNC:28850]
ENSG00000139800	2.41	2.11	2.00	1.66	1.56	1.80	0.390882170412268	1.99205288151622	0.0355060867691956	0.249003985913008	13:99962963-99971909:-	ZIC5	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0030154,biological_process cell differentiation;GO:0046872,molecular_function metal ion binding	NA	Zic family member 5 [Source:HGNC Symbol%3BAcc:HGNC:20322]
ENSG00000101940	22.99	23.66	22.53	20.44	20.56	21.78	0.149031623459774	5.1921683174733	0.0355455611077187	0.249047925387024	X:48590041-48608867:+	WDR13	6;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005886,cellular_component plasma membrane;GO:1904691,biological_process negative regulation of type B pancreatic cell proliferation;GO:1990841,molecular_function promoter-specific chromatin binding	NA	WD repeat domain 13 [Source:HGNC Symbol%3BAcc:HGNC:14352]
ENSG00000107537	53.68	55.21	56.15	50.37	53.06	46.70	0.148808831370145	5.77821973215753	0.0355524791578029	0.249047925387024	10:13277795-13302412:-	PHYH	19;GO:0001561,biological_process fatty acid alpha-oxidation;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006720,biological_process isoprenoid metabolic process;GO:0008198,molecular_function ferrous iron binding;GO:0016491,molecular_function oxidoreductase activity;GO:0031406,molecular_function carboxylic acid binding;GO:0031418,molecular_function L-ascorbic acid binding;GO:0046872,molecular_function metal ion binding;GO:0048037,molecular_function cofactor binding;GO:0048244,molecular_function phytanoyl-CoA dioxygenase activity;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0097089,biological_process methyl-branched fatty acid metabolic process	PHYH; phytanoyl-CoA hydroxylase [EC:1.14.11.18]; K00477	phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol%3BAcc:HGNC:8940]
ENSG00000105750	2.50	2.30	2.22	3.11	2.94	2.82	-0.319872696128121	2.53231926433201	0.0358532954199189	0.251013511589088	19:20923221-20950697:+	ZNF85	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 85 [Source:HGNC Symbol%3BAcc:HGNC:13160]
ENSG00000132405	22.09	20.60	22.52	22.64	25.12	25.32	-0.14996462265779	5.68555541174477	0.0358812281515972	0.251067466203932	4:6909241-7033118:+	TBC1D14	17;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0010507,biological_process negative regulation of autophagy;GO:0017137,molecular_function Rab GTPase binding;GO:0019901,molecular_function protein kinase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:0071955,biological_process recycling endosome to Golgi transport;GO:0090630,biological_process activation of GTPase activity;GO:2000785,biological_process regulation of autophagosome assembly	NA	TBC1 domain family member 14 [Source:HGNC Symbol%3BAcc:HGNC:29246]
ENSG00000109738	6.98	6.53	7.37	8.84	8.20	7.89	-0.236827979106177	3.54883330574283	0.0359066534327908	0.25110382482323	4:157076056-157172090:+	GLRB	41;GO:0001964,biological_process startle response;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0007218,biological_process neuropeptide signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0007340,biological_process acrosome reaction;GO:0007399,biological_process nervous system development;GO:0007601,biological_process visual perception;GO:0007628,biological_process adult walking behavior;GO:0008144,molecular_function drug binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016594,molecular_function glycine binding;GO:0016933,molecular_function extracellular-glycine-gated ion channel activity;GO:0016934,molecular_function extracellular-glycine-gated chloride channel activity;GO:0016935,cellular_component glycine-gated chloride channel complex;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0034220,biological_process ion transmembrane transport;GO:0034707,cellular_component chloride channel complex;GO:0042391,biological_process regulation of membrane potential;GO:0042995,cellular_component cell projection;GO:0043200,biological_process response to amino acid;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0050905,biological_process neuromuscular process;GO:0051291,biological_process protein heterooligomerization;GO:0060012,biological_process synaptic transmission, glycinergic;GO:0060013,biological_process righting reflex;GO:0060079,biological_process excitatory postsynaptic potential;GO:0097112,biological_process gamma-aminobutyric acid receptor clustering;GO:0098982,cellular_component GABA-ergic synapse;GO:1902476,biological_process chloride transmembrane transport	GLRB; glycine receptor beta; K05196	glycine receptor beta [Source:HGNC Symbol%3BAcc:HGNC:4329]
ENSG00000153879	76.59	63.29	69.35	88.52	74.66	77.97	-0.187695862828522	5.08915335054232	0.0360166901269944	0.251437235721167	19:33373329-33382686:+	CEBPG	29;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001889,biological_process liver development;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0008134,molecular_function transcription factor binding;GO:0016071,biological_process mRNA metabolic process;GO:0030183,biological_process B cell differentiation;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0042803,molecular_function protein homodimerization activity;GO:0043353,biological_process enucleate erythrocyte differentiation;GO:0043388,biological_process positive regulation of DNA binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044377,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending;GO:0045078,biological_process positive regulation of interferon-gamma biosynthetic process;GO:0045739,biological_process positive regulation of DNA repair;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity	CEBPG; CCAAT/enhancer binding protein (C/EBP), gamma; K10049	CCAAT/enhancer binding protein gamma [Source:HGNC Symbol%3BAcc:HGNC:1837]
ENSG00000003400	8.81	8.36	8.06	9.89	9.98	9.41	-0.200457127074277	4.0247395516512	0.0360216483798545	0.251437235721167	2:201182880-201229406:+	CASP10	19;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0031265,cellular_component CD95 death-inducing signaling complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035877,molecular_function death effector domain binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0097190,biological_process apoptotic signaling pathway;GO:0097194,biological_process execution phase of apoptosis;GO:0097199,molecular_function cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:0097342,cellular_component ripoptosome	CASP10; caspase 10 [EC:3.4.22.63]; K04400	caspase 10 [Source:HGNC Symbol%3BAcc:HGNC:1500]
ENSG00000036672	2.01	1.95	1.47	2.16	2.76	2.28	-0.399790740931972	2.13157234231431	0.0360385733060465	0.251437235721167	11:119355214-119381726:-	USP2	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005938,cellular_component cell cortex;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0007517,biological_process muscle organ development;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030332,molecular_function cyclin binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0045475,biological_process locomotor rhythm;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048511,biological_process rhythmic process;GO:0048512,biological_process circadian behavior;GO:0050821,biological_process protein stabilization	NA	ubiquitin specific peptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:12618]
ENSG00000107159	10.77	7.98	10.48	8.10	7.99	8.53	0.271546339196839	3.65178474177554	0.0360673161179955	0.251437235721167	9:35673855-35681159:+	CA9	20;GO:0001666,biological_process response to hypoxia;GO:0002009,biological_process morphogenesis of an epithelium;GO:0004089,molecular_function carbonate dehydratase activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0006730,biological_process one-carbon metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016829,molecular_function lyase activity;GO:0031528,cellular_component microvillus membrane;GO:0033574,biological_process response to testosterone;GO:0042493,biological_process response to drug;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0046903,biological_process secretion;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia	CA; carbonic anhydrase [EC:4.2.1.1]; K01672	carbonic anhydrase 9 [Source:HGNC Symbol%3BAcc:HGNC:1383]
ENSG00000108479	17.93	15.28	13.41	12.96	12.63	14.20	0.241262515310951	4.14010850945289	0.0360701751786927	0.251437235721167	17:75751593-75765711:-	GALK1	19;GO:0000166,molecular_function nucleotide binding;GO:0004335,molecular_function galactokinase activity;GO:0005524,molecular_function ATP binding;GO:0005534,molecular_function galactose binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006012,biological_process galactose metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019388,biological_process galactose catabolic process;GO:0019402,biological_process galactitol metabolic process;GO:0046835,biological_process carbohydrate phosphorylation;GO:0061623,biological_process glycolytic process from galactose;GO:0070062,cellular_component extracellular exosome	galK; galactokinase [EC:2.7.1.6]; K00849	galactokinase 1 [Source:HGNC Symbol%3BAcc:HGNC:4118]
ENSG00000103449	25.66	25.43	27.35	28.14	29.29	29.37	-0.133675058337376	6.77681676383098	0.0360758653685168	0.251437235721167	16:51135974-51151367:-	SALL1	46;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000792,cellular_component heterochromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001657,biological_process ureteric bud development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001822,biological_process kidney development;GO:0003281,biological_process ventricular septum development;GO:0003337,biological_process mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007507,biological_process heart development;GO:0008013,molecular_function beta-catenin binding;GO:0008406,biological_process gonad development;GO:0010369,cellular_component chromocenter;GO:0016575,biological_process histone deacetylation;GO:0016581,cellular_component NuRD complex;GO:0021553,biological_process olfactory nerve development;GO:0021889,biological_process olfactory bulb interneuron differentiation;GO:0021983,biological_process pituitary gland development;GO:0022008,biological_process neurogenesis;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030325,biological_process adrenal gland development;GO:0031129,biological_process inductive cell-cell signaling;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042473,biological_process outer ear morphogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048566,biological_process embryonic digestive tract development;GO:0060173,biological_process limb development;GO:0061034,biological_process olfactory bulb mitral cell layer development;GO:0072073,biological_process kidney epithelium development;GO:0072092,biological_process ureteric bud invasion	NA	spalt like transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:10524]
ENSG00000183864	30.04	34.26	34.59	36.06	40.42	36.04	-0.176816825923524	5.19085114285036	0.0361255197571094	0.25164201837542	22:41433491-41447023:-	TOB2	13;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007292,biological_process female gamete generation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0023052,biological_process signaling;GO:0042809,molecular_function vitamin D receptor binding;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045778,biological_process positive regulation of ossification;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	TOB; protein Tob/BTG; K14443	transducer of ERBB2%2C 2 [Source:HGNC Symbol%3BAcc:HGNC:11980]
ENSG00000235194	1.60	0.91	1.93	1.61	2.36	3.44	-0.692531334313936	0.884890153875169	0.0362022737755099	0.251792840081391	14:23295642-23302848:-	PPP1R3E	2;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process	PPP1R3; protein phosphatase 1 regulatory subunit 3A/B/C/D/E; K07189	protein phosphatase 1 regulatory subunit 3E [Source:HGNC Symbol%3BAcc:HGNC:14943]
ENSG00000168876	10.16	12.95	11.12	9.25	10.55	7.84	0.312551298383712	3.11734363816243	0.0362066783733757	0.251792840081391	11:94493628-94499583:+	ANKRD49	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	ankyrin repeat domain 49 [Source:HGNC Symbol%3BAcc:HGNC:25970]
ENSG00000029993	143.84	132.04	150.64	161.10	147.39	171.11	-0.155736702849464	6.50646577045993	0.0362279062875013	0.251792840081391	X:150980508-150990775:+	HMGB3	18;GO:0000400,molecular_function four-way junction DNA binding;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008301,molecular_function DNA binding, bending;GO:0032392,biological_process DNA geometric change;GO:0045087,biological_process innate immune response;GO:0045578,biological_process negative regulation of B cell differentiation;GO:0045638,biological_process negative regulation of myeloid cell differentiation	NA	high mobility group box 3 [Source:HGNC Symbol%3BAcc:HGNC:5004]
ENSG00000127720	3.16	3.65	2.85	2.41	2.55	2.72	0.327150119981462	2.55121563498702	0.0362396650106409	0.251792840081391	12:82358496-82479236:+	METTL25	3;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	methyltransferase like 25 [Source:HGNC Symbol%3BAcc:HGNC:26228]
ENSG00000074410	75.81	63.26	81.99	69.37	57.70	67.54	0.198155185252738	6.20701913571053	0.0362485946367071	0.251792840081391	15:63321377-63382161:-	CA12	10;GO:0004089,molecular_function carbonate dehydratase activity;GO:0005886,cellular_component plasma membrane;GO:0006730,biological_process one-carbon metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0046872,molecular_function metal ion binding;GO:0055064,biological_process chloride ion homeostasis	CA; carbonic anhydrase [EC:4.2.1.1]; K01672	carbonic anhydrase 12 [Source:HGNC Symbol%3BAcc:HGNC:1371]
ENSG00000141101	54.80	50.49	50.91	59.97	56.45	57.06	-0.137906957445976	6.09085899915471	0.0363223806925326	0.252164268197096	16:69741866-69754940:-	NOB1	12;GO:0000469,biological_process cleavage involved in rRNA processing;GO:0004521,molecular_function endoribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0007601,biological_process visual perception;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030688,cellular_component preribosome, small subunit precursor;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0046872,molecular_function metal ion binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NOB1; RNA-binding protein NOB1; K11883	NIN1/PSMD8 binding protein 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:29540]
ENSG00000125249	10.11	11.11	10.66	8.97	8.82	7.67	0.332566904107767	2.4505801635046	0.0364474163451487	0.252890877077882	13:97434221-97469128:+	RAP2A	27;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030033,biological_process microvillus assembly;GO:0030336,biological_process negative regulation of cell migration;GO:0030496,cellular_component midbody;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032486,biological_process Rap protein signal transduction;GO:0034613,biological_process cellular protein localization;GO:0035690,biological_process cellular response to drug;GO:0045184,biological_process establishment of protein localization;GO:0046328,biological_process regulation of JNK cascade;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane	NA	RAP2A%2C member of RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9861]
ENSG00000005073	12.69	10.34	11.26	13.68	12.95	14.18	-0.230487807123033	3.6811044364959	0.0364716043707271	0.25291733243231	7:27181509-27185223:-	HOXA11	35;GO:0001501,biological_process skeletal system development;GO:0001656,biological_process metanephros development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001759,biological_process organ induction;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0007501,biological_process mesodermal cell fate specification;GO:0008584,biological_process male gonad development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009954,biological_process proximal/distal pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0010720,biological_process positive regulation of cell development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0032993,cellular_component protein-DNA complex;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043234,cellular_component protein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048589,biological_process developmental growth;GO:0060065,biological_process uterus development;GO:0060272,biological_process embryonic skeletal joint morphogenesis;GO:0060348,biological_process bone development;GO:0060351,biological_process cartilage development involved in endochondral bone morphogenesis	NA	homeobox A11 [Source:HGNC Symbol%3BAcc:HGNC:5101]
ENSG00000089127	4.93	6.62	5.32	3.46	4.84	5.00	0.342904538050535	3.06298620545038	0.036517997473926	0.253097656417557	12:112906776-112933222:+	OAS1	26;GO:0000166,molecular_function nucleotide binding;GO:0001730,molecular_function 2'-5'-oligoadenylate synthetase activity;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006006,biological_process glucose metabolic process;GO:0006955,biological_process immune response;GO:0009615,biological_process response to virus;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0042593,biological_process glucose homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway	OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]; K14216	2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol%3BAcc:HGNC:8086]
ENSG00000065618	0.61	0.53	0.72	0.80	0.77	0.96	-0.425791164582916	1.80392862049371	0.0366083958538304	0.253512469503605	10:104031285-104086002:-	COL17A1	17;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005604,cellular_component basement membrane;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007160,biological_process cell-matrix adhesion;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030056,cellular_component hemidesmosome;GO:0031581,biological_process hemidesmosome assembly;GO:0050776,biological_process regulation of immune response	COL17A, BP180; collagen, type XVII, alpha; K07603	collagen type XVII alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2194]
ENSG00000132952	9.44	8.63	9.62	7.98	8.52	8.41	0.1691608191741	4.85337994071144	0.0366186947409944	0.253512469503605	13:30617692-30660770:+	USPL1	13;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008283,biological_process cell proliferation;GO:0015030,cellular_component Cajal body;GO:0016787,molecular_function hydrolase activity;GO:0016926,biological_process protein desumoylation;GO:0030576,biological_process Cajal body organization;GO:0032183,molecular_function SUMO binding;GO:0070140,molecular_function SUMO-specific isopeptidase activity	NA	ubiquitin specific peptidase like 1 [Source:HGNC Symbol%3BAcc:HGNC:20294]
ENSG00000214967	1.68	2.02	2.46	1.12	1.54	1.55	0.556768510332635	1.07290672658966	0.0366391300937995	0.253512553987923	16:16379054-16393954:+	NPIPA7	2;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex interacting protein family member A7 [Source:HGNC Symbol%3BAcc:HGNC:41982]
ENSG00000007168	76.77	78.94	74.92	84.98	87.31	82.78	-0.13438795391584	6.6406262600531	0.0367287719609336	0.253852290656818	17:2593209-2685615:+	PAFAH1B1	101;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000235,cellular_component astral microtubule;GO:0000776,cellular_component kinetochore;GO:0001667,biological_process ameboidal-type cell migration;GO:0001675,biological_process acrosome assembly;GO:0001764,biological_process neuron migration;GO:0001961,biological_process positive regulation of cytokine-mediated signaling pathway;GO:0004623,molecular_function phospholipase A2 activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005938,cellular_component cell cortex;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0007017,biological_process microtubule-based process;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007097,biological_process nuclear migration;GO:0007268,biological_process chemical synaptic transmission;GO:0007275,biological_process multicellular organism development;GO:0007281,biological_process germ cell development;GO:0007399,biological_process nervous system development;GO:0007405,biological_process neuroblast proliferation;GO:0007420,biological_process brain development;GO:0007611,biological_process learning or memory;GO:0008017,molecular_function microtubule binding;GO:0008090,biological_process retrograde axonal transport;GO:0008201,molecular_function heparin binding;GO:0008344,biological_process adult locomotory behavior;GO:0009306,biological_process protein secretion;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010977,biological_process negative regulation of neuron projection development;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016477,biological_process cell migration;GO:0017145,biological_process stem cell division;GO:0019226,biological_process transmission of nerve impulse;GO:0021540,biological_process corpus callosum morphogenesis;GO:0021766,biological_process hippocampus development;GO:0021819,biological_process layer formation in cerebral cortex;GO:0021895,biological_process cerebral cortex neuron differentiation;GO:0021987,biological_process cerebral cortex development;GO:0030036,biological_process actin cytoskeleton organization;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031023,biological_process microtubule organizing center organization;GO:0031252,cellular_component cell leading edge;GO:0031514,cellular_component motile cilium;GO:0031965,cellular_component nuclear membrane;GO:0031982,cellular_component vesicle;GO:0032403,molecular_function protein complex binding;GO:0032420,cellular_component stereocilium;GO:0034452,molecular_function dynactin binding;GO:0036035,biological_process osteoclast development;GO:0040019,biological_process positive regulation of embryonic development;GO:0042249,biological_process establishment of planar polarity of embryonic epithelium;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043087,biological_process regulation of GTPase activity;GO:0043274,molecular_function phospholipase binding;GO:0043622,biological_process cortical microtubule organization;GO:0045505,molecular_function dynein intermediate chain binding;GO:0045773,biological_process positive regulation of axon extension;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046469,biological_process platelet activating factor metabolic process;GO:0047496,biological_process vesicle transport along microtubule;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048854,biological_process brain morphogenesis;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051081,biological_process nuclear envelope disassembly;GO:0051130,biological_process positive regulation of cellular component organization;GO:0051219,molecular_function phosphoprotein binding;GO:0051301,biological_process cell division;GO:0051660,biological_process establishment of centrosome localization;GO:0051661,biological_process maintenance of centrosome location;GO:0060117,biological_process auditory receptor cell development;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0070840,molecular_function dynein complex binding;GO:0090102,biological_process cochlea development;GO:0090176,biological_process microtubule cytoskeleton organization involved in establishment of planar polarity;GO:0090724,cellular_component central region of growth cone;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1904115,cellular_component axon cytoplasm;GO:2000574,biological_process regulation of microtubule motor activity	PAFAH1B1, LIS1; platelet-activating factor acetylhydrolase IB subunit alpha; K16794	platelet activating factor acetylhydrolase 1b regulatory subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:8574]
ENSG00000135919	198.22	203.47	191.87	183.32	183.41	182.34	0.12371779485329	7.87471148612122	0.0367291318794526	0.253852290656818	2:223975111-224039319:-	SERPINE2	45;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007596,biological_process blood coagulation;GO:0008201,molecular_function heparin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009611,biological_process response to wounding;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010544,biological_process negative regulation of platelet activation;GO:0010757,biological_process negative regulation of plasminogen activation;GO:0010766,biological_process negative regulation of sodium ion transport;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0010955,biological_process negative regulation of protein processing;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0021683,biological_process cerebellar granular layer morphogenesis;GO:0030154,biological_process cell differentiation;GO:0030195,biological_process negative regulation of blood coagulation;GO:0030308,biological_process negative regulation of cell growth;GO:0030334,biological_process regulation of cell migration;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031012,cellular_component extracellular matrix;GO:0031091,cellular_component platelet alpha granule;GO:0031232,cellular_component extrinsic component of external side of plasma membrane;GO:0031594,cellular_component neuromuscular junction;GO:0032940,biological_process secretion by cell;GO:0033363,biological_process secretory granule organization;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042628,biological_process mating plug formation;GO:0045861,biological_process negative regulation of proteolysis;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0048505,biological_process regulation of timing of cell differentiation;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0050974,biological_process detection of mechanical stimulus involved in sensory perception;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060291,biological_process long-term synaptic potentiation;GO:0060384,biological_process innervation;GO:0061108,biological_process seminal vesicle epithelium development;GO:0090331,biological_process negative regulation of platelet aggregation;GO:1903561,cellular_component extracellular vesicle	NA	serpin family E member 2 [Source:HGNC Symbol%3BAcc:HGNC:8951]
ENSG00000125170	9.74	9.08	8.00	12.72	10.04	10.15	-0.28294694060001	3.46941764088694	0.0368078425838847	0.2541706927138	16:57471921-57487327:-	DOK4	9;GO:0000165,biological_process MAPK cascade;GO:0005057,molecular_function receptor signaling protein activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance	NA	docking protein 4 [Source:HGNC Symbol%3BAcc:HGNC:19868]
ENSG00000196189	0.71	0.96	1.26	0.62	0.60	0.74	0.583132987393885	1.00169028754635	0.0368161528638857	0.2541706927138	1:156147365-156177752:+	SEMA4A	22;GO:0001525,biological_process angiogenesis;GO:0002250,biological_process adaptive immune response;GO:0002292,biological_process T cell differentiation involved in immune response;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0008360,biological_process regulation of cell shape;GO:0010594,biological_process regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030154,biological_process cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045063,biological_process T-helper 1 cell differentiation;GO:0050919,biological_process negative chemotaxis;GO:0071526,biological_process semaphorin-plexin signaling pathway	SEMA4, CD100; semaphorin 4; K06521	semaphorin 4A [Source:HGNC Symbol%3BAcc:HGNC:10729]
ENSG00000152926	15.42	15.56	16.16	13.34	15.27	13.40	0.179253280025556	4.71879357230503	0.0368669717999507	0.254380056116058	7:64971775-65006684:-	ZNF117	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 117 [Source:HGNC Symbol%3BAcc:HGNC:12897]
ENSG00000158623	31.01	30.89	30.62	32.33	35.62	34.52	-0.135857625181849	6.42775212008249	0.0369761380438069	0.254991556409875	7:130506237-130668748:-	COPG2	19;GO:0000139,cellular_component Golgi membrane;GO:0005198,molecular_function structural molecule activity;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle	NA	coatomer protein complex subunit gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:2237]
ENSG00000102796	2.42	1.53	2.18	3.42	2.42	2.78	-0.454844748203163	1.77722680059055	0.0370078551593937	0.255068576398419	13:51767992-51804157:-	DHRS12	2;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	dehydrogenase/reductase 12 [Source:HGNC Symbol%3BAcc:HGNC:25832]
ENSG00000128713	23.05	20.92	26.57	19.94	21.47	20.39	0.209383248169444	4.49556161912586	0.0370435189521651	0.255172697421323	2:176104215-176109754:+	HOXD11	9;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0043565,molecular_function sequence-specific DNA binding	NA	homeobox D11 [Source:HGNC Symbol%3BAcc:HGNC:5134]
ENSG00000135114	2.61	1.80	2.86	1.75	1.82	1.82	0.464593952458997	1.77835797379562	0.0370705720450321	0.255217421405981	12:121019110-121039242:-	OASL	20;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006955,biological_process immune response;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway	OASL; 2'-5'-oligoadenylate synthase-like protein; K14608	2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol%3BAcc:HGNC:8090]
ENSG00000158966	0.38	0.44	0.46	0.69	0.66	0.54	-0.540392553486535	1.07212526095119	0.0370974355446641	0.255260791250508	1:64470791-64693058:+	CACHD1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	cache domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29314]
ENSG00000198162	14.18	15.17	14.19	12.30	14.20	12.15	0.181611458927509	4.77922571647213	0.0371190520978103	0.255261892011281	1:117367448-117528872:+	MAN1A2	18;GO:0000139,cellular_component Golgi membrane;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006491,biological_process N-glycan processing;GO:0007585,biological_process respiratory gaseous exchange;GO:0008152,biological_process metabolic process;GO:0009100,biological_process glycoprotein metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0046872,molecular_function metal ion binding;GO:0048286,biological_process lung alveolus development;GO:0070062,cellular_component extracellular exosome;GO:1904381,biological_process Golgi apparatus mannose trimming	MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]; K01230	mannosidase alpha class 1A member 2 [Source:HGNC Symbol%3BAcc:HGNC:6822]
ENSG00000122376	19.25	18.50	18.54	14.71	17.95	17.84	0.168254323005331	5.59808774218379	0.0371387236745649	0.255261892011281	10:87094160-87191468:+	FAM35A	NA	NA	family with sequence similarity 35 member A [Source:HGNC Symbol%3BAcc:HGNC:28773]
ENSG00000196230	736.15	920.87	678.40	877.43	1022.37	841.03	-0.219273813008542	10.1422095611084	0.0371794725893434	0.255400549668799	6:30720200-30725426:+	TUBB	37;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005641,cellular_component nuclear envelope lumen;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006928,biological_process movement of cell or subcellular component;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0009987,biological_process cellular process;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019904,molecular_function protein domain specific binding;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0032794,molecular_function GTPase activating protein binding;GO:0035578,cellular_component azurophil granule lumen;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0042288,molecular_function MHC class I protein binding;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0044297,cellular_component cell body;GO:0045121,cellular_component membrane raft;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	TUBB; tubulin beta; K07375	tubulin beta class I [Source:HGNC Symbol%3BAcc:HGNC:20778]
ENSG00000139200	1.58	2.26	2.52	1.06	1.79	1.16	0.666502101709824	0.6756384600811	0.0372207535444408	0.255542706718553	12:6693791-6700800:-	PIANP	6;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0050776,biological_process regulation of immune response	NA	PILR alpha associated neural protein [Source:HGNC Symbol%3BAcc:HGNC:25338]
ENSG00000158042	79.77	82.46	78.79	71.02	73.10	75.54	0.14313894629123	5.33795053025067	0.0372621856138019	0.25554801506838	11:6680781-6683401:-	MRPL17	12;GO:0000002,biological_process mitochondrial genome maintenance;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0019904,molecular_function protein domain specific binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17; K02879	mitochondrial ribosomal protein L17 [Source:HGNC Symbol%3BAcc:HGNC:14053]
ENSG00000165671	11.73	10.92	11.42	12.47	12.60	12.58	-0.131100792685654	6.63418652646694	0.0372627009807273	0.25554801506838	5:177133024-177300215:+	NSD1	32;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000414,biological_process regulation of histone H3-K36 methylation;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0010452,biological_process histone H3-K36 methylation;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030331,molecular_function estrogen receptor binding;GO:0032259,biological_process methylation;GO:0033135,biological_process regulation of peptidyl-serine phosphorylation;GO:0034770,biological_process histone H4-K20 methylation;GO:0034968,biological_process histone lysine methylation;GO:0042799,molecular_function histone methyltransferase activity (H4-K20 specific);GO:0042974,molecular_function retinoic acid receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0046975,molecular_function histone methyltransferase activity (H3-K36 specific);GO:0050681,molecular_function androgen receptor binding;GO:1903025,biological_process regulation of RNA polymerase II regulatory region sequence-specific DNA binding	NSD1; [histone H3]-lysine36 N-dimethyltransferase NSD1 [EC:2.1.1.357]; K15588	nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol%3BAcc:HGNC:14234]
ENSG00000159164	0.67	0.56	1.09	0.54	0.41	0.51	0.699895412595116	0.639473447141555	0.037300021143432	0.255662707042199	1:149903317-149917882:-	SV2A	26;GO:0004872,molecular_function receptor activity;GO:0005215,molecular_function transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0008021,cellular_component synaptic vesicle;GO:0014052,biological_process regulation of gamma-aminobutyric acid secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0022857,molecular_function transmembrane transporter activity;GO:0030054,cellular_component cell junction;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0030425,cellular_component dendrite;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031594,cellular_component neuromuscular junction;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043195,cellular_component terminal bouton;GO:0045202,cellular_component synapse;GO:0048786,cellular_component presynaptic active zone;GO:0055085,biological_process transmembrane transport	SV2; MFS transporter, VNT family, synaptic vesicle glycoprotein 2; K06258	synaptic vesicle glycoprotein 2A [Source:HGNC Symbol%3BAcc:HGNC:20566]
ENSG00000185347	5.87	5.42	3.94	6.57	6.81	5.85	-0.325841997443021	3.14808691000282	0.0374340303621194	0.256439635146241	14:105489854-105499575:+	C14orf80	NA	NA	chromosome 14 open reading frame 80 [Source:HGNC Symbol%3BAcc:HGNC:20127]
ENSG00000126464	5.64	6.51	6.27	5.25	5.80	5.46	0.166213871946888	5.15557401530317	0.0374838124785681	0.256639031603125	19:49591642-49626439:+	PRR12	8;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	proline rich 12 [Source:HGNC Symbol%3BAcc:HGNC:29217]
ENSG00000153406	14.36	14.35	14.55	15.77	19.04	15.66	-0.208852824931541	4.28808285986354	0.0375060971350345	0.256650046161622	16:4461679-4495763:-	NMRAL1	5;GO:0000050,biological_process urea cycle;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	NmrA like redox sensor 1 [Source:HGNC Symbol%3BAcc:HGNC:24987]
ENSG00000165879	0.76	0.69	0.44	0.98	1.27	1.34	-0.917650728768736	-0.113390920853898	0.0375682065701597	0.256933414961649	10:97319266-97321915:+	FRAT1	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016055,biological_process Wnt signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:1904886,biological_process beta-catenin destruction complex disassembly	FRAT1; frequently rearranged in advanced T-cell lymphomas 1; K03069	FRAT1%2C WNT signaling pathway regulator [Source:HGNC Symbol%3BAcc:HGNC:3944]
ENSG00000112996	42.58	40.78	42.31	49.40	43.25	47.57	-0.145377037062747	5.87287422684991	0.0377314394366507	0.257907685973098	5:44808924-44820428:+	MRPS30	10;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0006915,biological_process apoptotic process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S30 [Source:HGNC Symbol%3BAcc:HGNC:8769]
ENSG00000196865	6.55	6.10	6.86	5.71	5.78	5.42	0.22418145543528	3.74195699745817	0.0377867519042989	0.258143616614234	10:113854660-113917194:+	NHLRC2	5;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0031093,cellular_component platelet alpha granule lumen;GO:0045454,biological_process cell redox homeostasis	NA	NHL repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24731]
ENSG00000121310	12.67	12.67	11.52	10.45	11.04	10.03	0.236598999629893	3.53048565621472	0.037920193993084	0.258786156650485	1:52895909-52927212:-	ECHDC2	8;GO:0003824,molecular_function catalytic activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0005739,cellular_component mitochondrion;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016829,molecular_function lyase activity	NA	enoyl-CoA hydratase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:23408]
ENSG00000160948	88.33	88.84	95.91	83.30	78.66	87.49	0.142586637179369	6.0937710071387	0.0379432334309171	0.258786156650485	8:144423600-144428563:-	VPS28	27;GO:0000813,cellular_component ESCRT I complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031902,cellular_component late endosome membrane;GO:0032403,molecular_function protein complex binding;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043328,biological_process protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043657,cellular_component host cell;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus;GO:2000397,biological_process positive regulation of ubiquitin-dependent endocytosis	VPS28; ESCRT-I complex subunit VPS28; K12184	VPS28%2C ESCRT-I subunit [Source:HGNC Symbol%3BAcc:HGNC:18178]
ENSG00000140398	4.22	3.99	5.24	3.68	3.60	3.28	0.370693634437353	2.33412862138295	0.0379433501251819	0.258786156650485	15:75346954-75357114:+	NEIL1	26;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003824,molecular_function catalytic activity;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0008022,molecular_function protein C-terminus binding;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016799,molecular_function hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0016829,molecular_function lyase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0032074,biological_process negative regulation of nuclease activity;GO:0045008,biological_process depyrimidination	NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]; K10567	nei like DNA glycosylase 1 [Source:HGNC Symbol%3BAcc:HGNC:18448]
ENSG00000101146	23.29	24.11	25.38	29.36	26.21	26.56	-0.162409148852724	5.17844927773284	0.0380115782630016	0.25909931507052	20:57351009-57379211:+	RAE1	31;GO:0000922,cellular_component spindle pole;GO:0000972,biological_process transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006110,biological_process regulation of glycolytic process;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008017,molecular_function microtubule binding;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0043130,molecular_function ubiquitin binding;GO:0043657,cellular_component host cell;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0075733,biological_process intracellular transport of virus;GO:0097431,cellular_component mitotic spindle pole;GO:1900034,biological_process regulation of cellular response to heat	RAE1, GLE2; mRNA export factor; K14298	ribonucleic acid export 1 [Source:HGNC Symbol%3BAcc:HGNC:9828]
ENSG00000106100	2.30	1.41	2.28	2.47	2.53	2.78	-0.341696876325758	2.79080367956264	0.0380453487324801	0.25909931507052	7:30424526-30478784:-	NOD1	48;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0002376,biological_process immune system process;GO:0002606,biological_process positive regulation of dendritic cell antigen processing and presentation;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007254,biological_process JNK cascade;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0009595,biological_process detection of biotic stimulus;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016045,biological_process detection of bacterium;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016579,biological_process protein deubiquitination;GO:0032731,biological_process positive regulation of interleukin-1 beta production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0035556,biological_process intracellular signal transduction;GO:0042228,biological_process interleukin-8 biosynthetic process;GO:0042742,biological_process defense response to bacterium;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042834,molecular_function peptidoglycan binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045087,biological_process innate immune response;GO:0046330,biological_process positive regulation of JNK cascade;GO:0050700,molecular_function CARD domain binding;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051259,biological_process protein oligomerization;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0071225,biological_process cellular response to muramyl dipeptide;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1904417,biological_process positive regulation of xenophagy	NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1; K08727	nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16390]
ENSG00000100918	5.00	4.56	5.68	4.75	3.62	4.21	0.294861910721638	3.17066266426801	0.038051885231093	0.25909931507052	14:24171852-24180257:+	REC8	29;GO:0000228,cellular_component nuclear chromosome;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000775,cellular_component chromosome, centromeric region;GO:0000778,cellular_component condensed nuclear chromosome kinetochore;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000793,cellular_component condensed chromosome;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000795,cellular_component synaptonemal complex;GO:0000798,cellular_component nuclear cohesin complex;GO:0000800,cellular_component lateral element;GO:0001556,biological_process oocyte maturation;GO:0001673,cellular_component male germ cell nucleus;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006302,biological_process double-strand break repair;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007129,biological_process synapsis;GO:0007130,biological_process synaptonemal complex assembly;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007141,biological_process male meiosis I;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0009566,biological_process fertilization;GO:0030893,cellular_component meiotic cohesin complex;GO:0034991,cellular_component nuclear meiotic cohesin complex;GO:0051321,biological_process meiotic cell cycle;GO:0072520,biological_process seminiferous tubule development	REC8L; meiotic recombination protein REC8, animal type; K13054	REC8 meiotic recombination protein [Source:HGNC Symbol%3BAcc:HGNC:16879]
ENSG00000146476	41.75	42.55	47.90	46.86	49.59	51.61	-0.150880501416853	5.95503321611449	0.038109638296623	0.259350296149113	6:151452257-151470101:+	ARMT1	10;GO:0005515,molecular_function protein binding;GO:0006479,biological_process protein methylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008168,molecular_function methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0032259,biological_process methylation;GO:0051998,molecular_function protein carboxyl O-methyltransferase activity;GO:2001020,biological_process regulation of response to DNA damage stimulus	NA	acidic residue methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:17872]
ENSG00000099956	60.81	61.73	59.17	67.50	67.62	65.32	-0.130460694963464	6.27070519818642	0.0381766679921564	0.259664098513226	22:23786962-23834516:+	SMARCB1	48;GO:0000228,cellular_component nuclear chromosome;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0001650,cellular_component fibrillar center;GO:0001741,cellular_component XY body;GO:0001824,biological_process blastocyst development;GO:0001835,biological_process blastocyst hatching;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0015074,biological_process DNA integration;GO:0016032,biological_process viral process;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0030154,biological_process cell differentiation;GO:0030957,molecular_function Tat protein binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0039692,biological_process single stranded viral RNA replication via double stranded DNA intermediate;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:0090240,biological_process positive regulation of histone H4 acetylation;GO:0090544,cellular_component BAF-type complex;GO:1900110,biological_process negative regulation of histone H3-K9 dimethylation;GO:1900113,biological_process negative regulation of histone H3-K9 trimethylation;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1902661,biological_process positive regulation of glucose mediated signaling pathway;GO:2000617,biological_process positive regulation of histone H3-K9 acetylation	SMARCB1, SNF5, INI1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; K11648	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily b%2C member 1 [Source:HGNC Symbol%3BAcc:HGNC:11103]
ENSG00000088305	24.49	18.74	20.45	25.56	22.07	25.93	-0.19276318012562	5.89946213461078	0.0382875214048349	0.260227532941236	20:32762384-32809356:+	DNMT3B	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001666,biological_process response to hypoxia;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003886,molecular_function DNA (cytosine-5-)-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006306,biological_process DNA methylation;GO:0008168,molecular_function methyltransferase activity;GO:0009008,molecular_function DNA-methyltransferase activity;GO:0009636,biological_process response to toxic substance;GO:0010212,biological_process response to ionizing radiation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0014823,biological_process response to activity;GO:0016740,molecular_function transferase activity;GO:0031000,biological_process response to caffeine;GO:0032259,biological_process methylation;GO:0032355,biological_process response to estradiol;GO:0033189,biological_process response to vitamin A;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042826,molecular_function histone deacetylase binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0051573,biological_process negative regulation of histone H3-K9 methylation;GO:0071455,biological_process cellular response to hyperoxia;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0090116,biological_process C-5 methylation of cytosine	DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]; K17399	DNA methyltransferase 3 beta [Source:HGNC Symbol%3BAcc:HGNC:2979]
ENSG00000166073	9.82	8.57	10.01	9.04	7.35	7.98	0.239107873378029	3.86779680386965	0.0383014341967001	0.260227532941236	15:39799031-39920892:-	GPR176	12;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030818,biological_process negative regulation of cAMP biosynthetic process;GO:0048511,biological_process rhythmic process;GO:0048512,biological_process circadian behavior	NA	G protein-coupled receptor 176 [Source:HGNC Symbol%3BAcc:HGNC:32370]
ENSG00000064205	1.09	0.42	0.97	1.81	1.59	1.01	-0.74862101380582	0.281259362548469	0.038330618467169	0.260283351768582	20:44714843-44728509:+	WISP2	12;GO:0001558,biological_process regulation of cell growth;GO:0005178,molecular_function integrin binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008201,molecular_function heparin binding;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome	NA	WNT1 inducible signaling pathway protein 2 [Source:HGNC Symbol%3BAcc:HGNC:12770]
ENSG00000112079	39.39	38.23	33.82	41.22	42.46	40.98	-0.150987170711274	5.78359234958754	0.0383806348565235	0.260472455848619	6:36493891-36547470:-	STK38	20;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0035556,biological_process intracellular signal transduction;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding	NA	serine/threonine kinase 38 [Source:HGNC Symbol%3BAcc:HGNC:17847]
ENSG00000148516	10.73	9.66	10.16	9.35	9.06	9.31	0.155985475813093	5.08794766605575	0.0384004345607809	0.260472455848619	10:31318494-31529814:+	ZEB1	44;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0007389,biological_process pattern specification process;GO:0007399,biological_process nervous system development;GO:0007417,biological_process central nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010464,biological_process regulation of mesenchymal cell proliferation;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030154,biological_process cell differentiation;GO:0030857,biological_process negative regulation of epithelial cell differentiation;GO:0033081,biological_process regulation of T cell differentiation in thymus;GO:0045602,biological_process negative regulation of endothelial cell differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048513,biological_process animal organ development;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0048598,biological_process embryonic morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048752,biological_process semicircular canal morphogenesis;GO:0051150,biological_process regulation of smooth muscle cell differentiation;GO:0051216,biological_process cartilage development;GO:0070888,molecular_function E-box binding;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0090103,biological_process cochlea morphogenesis	ZEB1; zinc finger homeobox protein 1; K09299	zinc finger E-box binding homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:11642]
ENSG00000074071	66.34	65.55	58.23	67.99	69.89	76.05	-0.160687996893879	5.51258164540854	0.0384789530640203	0.260782504176007	16:1771889-1773155:-	MRPS34	8;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S34 [Source:HGNC Symbol%3BAcc:HGNC:16618]
ENSG00000166133	5.03	4.19	4.61	6.10	5.44	5.35	-0.266751573157985	3.10668334133252	0.0384881614154873	0.260782504176007	15:40569299-40574943:+	RPUSD2	8;GO:0000455,biological_process enzyme-directed rRNA pseudouridine synthesis;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0019239,molecular_function deaminase activity	NA	RNA pseudouridylate synthase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24180]
ENSG00000275342	4.24	4.06	4.68	4.10	3.56	3.65	0.213366276671685	4.10697929100454	0.0385335083098583	0.260947320594802	8:8317735-8386498:-	PRAG1	10;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation	NA	PEAK1 related kinase activating pseudokinase 1 [Source:HGNC Symbol%3BAcc:HGNC:25438]
ENSG00000143761	327.38	363.25	346.72	318.38	331.72	296.68	0.142826821907218	7.48996927423582	0.0385625636809046	0.260970619052602	1:228082659-228099212:+	ARF1	64;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002090,biological_process regulation of receptor internalization;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005778,cellular_component peroxisomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0007015,biological_process actin filament organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0012505,cellular_component endomembrane system;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019003,molecular_function GDP binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019904,molecular_function protein domain specific binding;GO:0030017,cellular_component sarcomere;GO:0030054,cellular_component cell junction;GO:0030137,cellular_component COPI-coated vesicle;GO:0031252,cellular_component cell leading edge;GO:0034315,biological_process regulation of Arp2/3 complex-mediated actin nucleation;GO:0034379,biological_process very-low-density lipoprotein particle assembly;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043005,cellular_component neuron projection;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045807,biological_process positive regulation of endocytosis;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050714,biological_process positive regulation of protein secretion;GO:0055108,biological_process Golgi to transport vesicle transport;GO:0060292,biological_process long term synaptic depression;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0070062,cellular_component extracellular exosome;GO:0070142,biological_process synaptic vesicle budding;GO:0097061,biological_process dendritic spine organization;GO:0097212,biological_process lysosomal membrane organization;GO:0098586,biological_process cellular response to virus;GO:1902307,biological_process positive regulation of sodium ion transmembrane transport;GO:1902824,biological_process positive regulation of late endosome to lysosome transport;GO:1902953,biological_process positive regulation of ER to Golgi vesicle-mediated transport;GO:1903725,biological_process regulation of phospholipid metabolic process;GO:1990386,biological_process mitotic cleavage furrow ingression;GO:1990583,molecular_function phospholipase D activator activity	ARF1; ADP-ribosylation factor 1; K07937	ADP ribosylation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:652]
ENSG00000164920	0.85	0.75	0.73	1.17	1.24	1.25	-0.628231409207783	0.650777306524497	0.0385789966939116	0.260970619052602	8:98944402-98952104:+	OSR2	31;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001656,biological_process metanephros development;GO:0001823,biological_process mesonephros development;GO:0002062,biological_process chondrocyte differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009790,biological_process embryo development;GO:0010628,biological_process positive regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0030501,biological_process positive regulation of bone mineralization;GO:0033687,biological_process osteoblast proliferation;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0036023,biological_process embryonic skeletal limb joint morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0042476,biological_process odontogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0060021,biological_process palate development;GO:0060272,biological_process embryonic skeletal joint morphogenesis;GO:0060322,biological_process head development;GO:0060349,biological_process bone morphogenesis;GO:0061029,biological_process eyelid development in camera-type eye;GO:0072498,biological_process embryonic skeletal joint development	NA	odd-skipped related transciption factor 2 [Source:HGNC Symbol%3BAcc:HGNC:15830]
ENSG00000122512	18.76	19.40	20.55	20.96	21.29	23.28	-0.147276682042926	5.74873576403047	0.0386589899584315	0.261369304114385	7:5973238-6009125:-	PMS2	25;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030983,molecular_function mismatched DNA binding;GO:0032138,molecular_function single base insertion or deletion binding;GO:0032300,cellular_component mismatch repair complex;GO:0032389,cellular_component MutLalpha complex;GO:0032407,molecular_function MutSalpha complex binding;GO:0042493,biological_process response to drug;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	PMS2; DNA mismatch repair protein PMS2; K10858	PMS1 homolog 2%2C mismatch repair system component [Source:HGNC Symbol%3BAcc:HGNC:9122]
ENSG00000072274	73.71	87.34	75.57	64.23	79.80	65.16	0.188675074104653	7.45392623472735	0.0386900793898117	0.26143710150557	3:196027182-196082189:-	TFRC	45;GO:0001618,molecular_function virus receptor activity;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004998,molecular_function transferrin receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0030316,biological_process osteoclast differentiation;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031623,biological_process receptor internalization;GO:0033570,molecular_function transferrin transmembrane transporter activity;GO:0033572,biological_process transferrin transport;GO:0035690,biological_process cellular response to drug;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042470,cellular_component melanosome;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045780,biological_process positive regulation of bone resorption;GO:0045830,biological_process positive regulation of isotype switching;GO:0046718,biological_process viral entry into host cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle;GO:0097286,biological_process iron ion import;GO:1903561,cellular_component extracellular vesicle;GO:1990712,cellular_component HFE-transferrin receptor complex;GO:1990830,biological_process cellular response to leukemia inhibitory factor	TFRC, CD71; transferrin receptor; K06503	transferrin receptor [Source:HGNC Symbol%3BAcc:HGNC:11763]
ENSG00000184207	8.36	10.22	7.64	6.69	7.40	7.23	0.295870096445788	2.94859823136727	0.038738352045844	0.261620872657814	16:2211996-2214807:-	PGP	18;GO:0000121,molecular_function glycerol-1-phosphatase activity;GO:0000287,molecular_function magnesium ion binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006114,biological_process glycerol biosynthetic process;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008967,molecular_function phosphoglycolate phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043136,molecular_function glycerol-3-phosphatase activity;GO:0045721,biological_process negative regulation of gluconeogenesis;GO:0046872,molecular_function metal ion binding;GO:0098519,molecular_function nucleotide phosphatase activity, acting on free nucleotides	gph; phosphoglycolate phosphatase [EC:3.1.3.18]; K01091	phosphoglycolate phosphatase [Source:HGNC Symbol%3BAcc:HGNC:8909]
ENSG00000178385	2.48	2.48	2.58	2.07	1.71	2.26	0.32851546066863	2.47568762939178	0.0388453464242417	0.262140935401256	2:207821287-208025560:-	PLEKHM3	1;GO:0046872,molecular_function metal ion binding	NA	pleckstrin homology domain containing M3 [Source:HGNC Symbol%3BAcc:HGNC:34006]
ENSG00000107863	24.51	23.47	26.08	22.36	22.46	23.29	0.133400769353285	7.21715736262981	0.0388575945491269	0.262140935401256	10:24583608-24723668:-	ARHGAP21	20;GO:0000139,cellular_component Golgi membrane;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007030,biological_process Golgi organization;GO:0007165,biological_process signal transduction;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051683,biological_process establishment of Golgi localization;GO:0051684,biological_process maintenance of Golgi location;GO:0072384,biological_process organelle transport along microtubule	NA	Rho GTPase activating protein 21 [Source:HGNC Symbol%3BAcc:HGNC:23725]
ENSG00000184925	1.25	2.45	2.72	1.08	1.46	1.13	0.793148720588416	0.237554301577662	0.0389351069014272	0.262506176295999	9:136949550-136955497:+	LCN12	6;GO:0001972,molecular_function retinoic acid binding;GO:0005215,molecular_function transporter activity;GO:0005576,cellular_component extracellular region;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0015909,biological_process long-chain fatty acid transport	NA	lipocalin 12 [Source:HGNC Symbol%3BAcc:HGNC:28733]
ENSG00000170231	1.89	3.07	1.84	1.74	0.81	1.25	0.803180293058047	0.158039129371099	0.0389540301890945	0.262506176295999	5:160187366-160238735:+	FABP6	13;GO:0005215,molecular_function transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008206,biological_process bile acid metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0015721,biological_process bile acid and bile salt transport;GO:0016020,cellular_component membrane;GO:0019433,biological_process triglyceride catabolic process;GO:0032052,molecular_function bile acid binding	FABP6; fatty acid-binding protein 6, ileal (gastrotropin); K08755	fatty acid binding protein 6 [Source:HGNC Symbol%3BAcc:HGNC:3561]
ENSG00000166762	2.74	3.19	2.99	1.86	2.72	2.26	0.388222673182653	2.15431048283407	0.0389907026487258	0.262610739000886	15:43628502-43668118:-	CATSPER2	31;GO:0005216,molecular_function ion channel activity;GO:0005227,molecular_function calcium activated cation channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005248,molecular_function voltage-gated sodium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019228,biological_process neuronal action potential;GO:0030154,biological_process cell differentiation;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0032570,biological_process response to progesterone;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035036,biological_process sperm-egg recognition;GO:0035725,biological_process sodium ion transmembrane transport;GO:0036128,cellular_component CatSper complex;GO:0042995,cellular_component cell projection;GO:0055085,biological_process transmembrane transport;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086010,biological_process membrane depolarization during action potential;GO:0098655,biological_process cation transmembrane transport	NA	cation channel sperm associated 2 [Source:HGNC Symbol%3BAcc:HGNC:18810]
ENSG00000105996	24.86	25.33	25.38	22.63	18.76	24.81	0.200339658793055	4.7444422211189	0.0390354088376899	0.2626194735134	7:27100353-27102811:-	HOXA2	8;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding	NA	homeobox A2 [Source:HGNC Symbol%3BAcc:HGNC:5103]
ENSG00000133401	0.69	0.67	0.60	0.80	0.85	0.79	-0.299487663287135	2.68246501101461	0.0390595804149919	0.2626194735134	5:31639409-32110931:+	PDZD2	6;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005911,cellular_component cell-cell junction;GO:0007155,biological_process cell adhesion	NA	PDZ domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18486]
ENSG00000100883	92.19	98.79	88.49	83.48	87.07	85.79	0.134921577560743	7.07976474531908	0.0390815884602354	0.2626194735134	14:34981956-35029567:+	SRP54	22;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005786,cellular_component signal recognition particle, endoplasmic reticulum targeting;GO:0005829,cellular_component cytosol;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006616,biological_process SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0006617,biological_process SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0008144,molecular_function drug binding;GO:0008312,molecular_function 7S RNA binding;GO:0016607,cellular_component nuclear speck;GO:0019003,molecular_function GDP binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030942,molecular_function endoplasmic reticulum signal peptide binding;GO:0042493,biological_process response to drug;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0045047,biological_process protein targeting to ER;GO:0048500,cellular_component signal recognition particle	SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]; K03106	signal recognition particle 54 [Source:HGNC Symbol%3BAcc:HGNC:11301]
ENSG00000133226	63.07	62.67	67.73	60.61	58.26	59.50	0.129335052494143	7.41907495540614	0.0391062009863127	0.2626194735134	1:24631715-24673267:+	SRRM1	18;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0071013,cellular_component catalytic step 2 spliceosome	SRRM1, SRM160; serine/arginine repetitive matrix protein 1; K13171	serine and arginine repetitive matrix 1 [Source:HGNC Symbol%3BAcc:HGNC:16638]
ENSG00000146592	4.44	5.89	5.10	5.81	7.28	5.99	-0.304476464049858	3.19849327100729	0.0391169619879851	0.2626194735134	7:28299320-28825894:+	CREB5	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5; K09047	cAMP responsive element binding protein 5 [Source:HGNC Symbol%3BAcc:HGNC:16844]
ENSG00000269190	37.46	34.82	37.00	40.46	40.82	40.96	-0.146325398360213	5.13216524310341	0.0391307259574328	0.2626194735134	19:38941400-38975910:-	FBXO17	6;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification	NA	F-box protein 17 [Source:HGNC Symbol%3BAcc:HGNC:18754]
ENSG00000132199	30.31	32.16	30.28	34.06	33.79	34.83	-0.137964874188602	5.69679701657484	0.0391400971561904	0.2626194735134	18:670323-712676:-	ENOSF1	10;GO:0000287,molecular_function magnesium ion binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0009063,biological_process cellular amino acid catabolic process;GO:0016052,biological_process carbohydrate catabolic process;GO:0016829,molecular_function lyase activity;GO:0016853,molecular_function isomerase activity;GO:0044275,biological_process cellular carbohydrate catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050023,molecular_function L-fuconate dehydratase activity	NA	enolase superfamily member 1 [Source:HGNC Symbol%3BAcc:HGNC:30365]
ENSG00000136504	25.74	25.03	24.65	27.53	26.89	29.39	-0.140771461443017	5.61066126669536	0.0392466721131485	0.262938943914302	17:49788554-49835030:+	KAT7	32;GO:0000123,cellular_component histone acetyltransferase complex;GO:0003688,molecular_function DNA replication origin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0043966,biological_process histone H3 acetylation;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043983,biological_process histone H4-K12 acetylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0072708,biological_process response to sorbitol;GO:0072710,biological_process response to hydroxyurea;GO:0072716,biological_process response to actinomycin D;GO:0072720,biological_process response to dithiothreitol;GO:0072739,biological_process response to anisomycin;GO:0090240,biological_process positive regulation of histone H4 acetylation;GO:1900182,biological_process positive regulation of protein localization to nucleus	NA	lysine acetyltransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:17016]
ENSG00000087274	77.87	81.08	81.27	87.95	89.21	86.62	-0.123480627515514	7.69756455966635	0.039247958769854	0.262938943914302	4:2843856-2930076:+	ADD1	37;GO:0000902,biological_process cell morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006884,biological_process cell volume homeostasis;GO:0008134,molecular_function transcription factor binding;GO:0008290,cellular_component F-actin capping protein complex;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0020027,biological_process hemoglobin metabolic process;GO:0030036,biological_process actin cytoskeleton organization;GO:0030218,biological_process erythrocyte differentiation;GO:0030507,molecular_function spectrin binding;GO:0032092,biological_process positive regulation of protein binding;GO:0035264,biological_process multicellular organism growth;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042803,molecular_function protein homodimerization activity;GO:0045296,molecular_function cadherin binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0051015,molecular_function actin filament binding;GO:0051016,biological_process barbed-end actin filament capping;GO:0051017,biological_process actin filament bundle assembly;GO:0055085,biological_process transmembrane transport;GO:0071277,biological_process cellular response to calcium ion;GO:1903142,biological_process positive regulation of establishment of endothelial barrier;GO:1903393,biological_process positive regulation of adherens junction organization	NA	adducin 1 [Source:HGNC Symbol%3BAcc:HGNC:243]
ENSG00000100591	70.89	85.14	63.13	59.30	69.11	63.62	0.199317848091463	6.21264197535777	0.0392512578001452	0.262938943914302	14:77457869-77469474:+	AHSA1	10;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006950,biological_process response to stress;GO:0032781,biological_process positive regulation of ATPase activity;GO:0045296,molecular_function cadherin binding;GO:0051087,molecular_function chaperone binding;GO:0070062,cellular_component extracellular exosome	NA	activator of HSP90 ATPase activity 1 [Source:HGNC Symbol%3BAcc:HGNC:1189]
ENSG00000244038	379.87	381.42	358.05	344.97	350.38	342.13	0.121165053064281	8.94326829183465	0.0392960749248768	0.263097183410192	1:20651766-20661544:-	DDOST	20;GO:0004576,molecular_function oligosaccharyl transferase activity;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0034097,biological_process response to cytokine;GO:0035577,cellular_component azurophil granule membrane;GO:0042110,biological_process T cell activation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation	WBP1; oligosaccharyltransferase complex subunit beta; K12670	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:2728]
ENSG00000203778	49.73	46.19	44.77	55.22	57.83	53.03	-0.224091571436907	3.63853014491157	0.0394284483880023	0.263748285437044	6:112087598-112102790:+	FAM229B	NA	NA	family with sequence similarity 229 member B [Source:HGNC Symbol%3BAcc:HGNC:33858]
ENSG00000158457	42.92	41.42	43.95	37.92	40.47	38.26	0.151596232888582	5.12217425283409	0.0394358187199833	0.263748285437044	7:129144891-129169697:+	TSPAN33	10;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0051604,biological_process protein maturation;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0097197,cellular_component tetraspanin-enriched microdomain	NA	tetraspanin 33 [Source:HGNC Symbol%3BAcc:HGNC:28743]
ENSG00000182004	208.29	194.25	188.54	218.11	220.93	216.56	-0.136427741557137	5.84727568388839	0.039469553549426	0.26383175455521	1:203861602-203870550:+	SNRPE	32;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005683,cellular_component U7 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0034709,cellular_component methylosome;GO:0034715,cellular_component pICln-Sm protein complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0042633,biological_process hair cycle;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0051170,biological_process nuclear import;GO:0070062,cellular_component extracellular exosome;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	small nuclear ribonucleoprotein polypeptide E [Source:HGNC Symbol%3BAcc:HGNC:11161]
ENSG00000100116	10.54	12.50	10.84	12.21	13.51	13.50	-0.208663755253947	4.22276738415832	0.0394934825614789	0.263849622731775	22:37807904-37817176:+	GCAT	15;GO:0003824,molecular_function catalytic activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006567,biological_process threonine catabolic process;GO:0008152,biological_process metabolic process;GO:0008890,molecular_function glycine C-acetyltransferase activity;GO:0009058,biological_process biosynthetic process;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019518,biological_process L-threonine catabolic process to glycine;GO:0030170,molecular_function pyridoxal phosphate binding	kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29]; K00639	glycine C-acetyltransferase [Source:HGNC Symbol%3BAcc:HGNC:4188]
ENSG00000169255	7.52	8.41	9.14	7.03	7.34	6.81	0.253217444970152	3.39961414260013	0.0396139627187848	0.264419515521159	3:161083882-161105384:-	B3GALNT1	12;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008378,molecular_function galactosyltransferase activity;GO:0008499,molecular_function UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0009312,biological_process oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0047273,molecular_function galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity	B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]; K00719	beta-1%2C3-N-acetylgalactosaminyltransferase 1 (globoside blood group) [Source:HGNC Symbol%3BAcc:HGNC:918]
ENSG00000138433	30.18	30.15	29.87	33.87	32.31	33.86	-0.138150234654485	5.51828903263364	0.0396213887754254	0.264419515521159	2:174348021-174395715:-	CIR1	19;GO:0000118,cellular_component histone deacetylase complex;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0019901,molecular_function protein kinase binding;GO:0043234,cellular_component protein complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated	CIR; CBF1 interacting corepressor; K06066	corepressor interacting with RBPJ%2C 1 [Source:HGNC Symbol%3BAcc:HGNC:24217]
ENSG00000006634	26.83	27.41	27.23	30.18	29.03	30.74	-0.132336694646083	5.85733753427248	0.0396842403733966	0.264696655429861	7:87876215-87909541:+	DBF4	11;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0007049,biological_process cell cycle;GO:0008047,molecular_function enzyme activator activity;GO:0008270,molecular_function zinc ion binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046872,molecular_function metal ion binding	ASK, DBF4; activator of S phase kinase; K06629	DBF4 zinc finger [Source:HGNC Symbol%3BAcc:HGNC:17364]
ENSG00000101557	60.23	66.36	58.78	67.31	72.59	66.79	-0.147325980023433	6.63173295791285	0.0397558823374977	0.265032098525971	18:158382-214629:+	USP14	28;GO:0000502,cellular_component proteasome complex;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007268,biological_process chemical synaptic transmission;GO:0008193,molecular_function tRNA guanylyltransferase activity;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0009986,cellular_component cell surface;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0045202,cellular_component synapse;GO:0050920,biological_process regulation of chemotaxis;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0070628,molecular_function proteasome binding;GO:1903070,biological_process negative regulation of ER-associated ubiquitin-dependent protein catabolic process	NA	ubiquitin specific peptidase 14 [Source:HGNC Symbol%3BAcc:HGNC:12612]
ENSG00000183840	14.70	16.69	14.06	13.50	13.35	13.03	0.192446615760618	4.32456267673205	0.0398173231114493	0.265268884518478	2:132416573-132646559:+	GPR39	9;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	G protein-coupled receptor 39 [Source:HGNC Symbol%3BAcc:HGNC:4496]
ENSG00000106853	214.52	209.75	208.16	194.94	183.49	204.54	0.129207863624408	7.72362332608088	0.0398501006633331	0.265268884518478	9:111549721-111599855:-	PTGR1	10;GO:0005737,cellular_component cytoplasm;GO:0006691,biological_process leukotriene metabolic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0032440,molecular_function 2-alkenal reductase [NAD(P)] activity;GO:0036132,molecular_function 13-prostaglandin reductase activity;GO:0047522,molecular_function 15-oxoprostaglandin 13-oxidase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0097327,biological_process response to antineoplastic agent	NA	prostaglandin reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:18429]
ENSG00000158402	13.12	13.72	10.22	16.17	13.33	14.62	-0.245429919873117	4.34502777140736	0.0398555119332121	0.265268884518478	5:138285264-138338355:-	CDC25C	27;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006470,biological_process protein dephosphorylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0007283,biological_process spermatogenesis;GO:0008283,biological_process cell proliferation;GO:0016032,biological_process viral process;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050699,molecular_function WW domain binding;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle;GO:1902751,biological_process positive regulation of cell cycle G2/M phase transition	CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]; K05867	cell division cycle 25C [Source:HGNC Symbol%3BAcc:HGNC:1727]
ENSG00000158296	1.74	1.83	1.70	1.18	1.23	1.52	0.424623524728677	1.70356730739663	0.0400369589575927	0.266112716541732	20:46557822-46684467:-	SLC13A3	18;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006835,biological_process dicarboxylic acid transport;GO:0015137,molecular_function citrate transmembrane transporter activity;GO:0015141,molecular_function succinate transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015362,molecular_function high-affinity sodium:dicarboxylate symporter activity;GO:0015746,biological_process citrate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017153,molecular_function sodium:dicarboxylate symporter activity;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071422,biological_process succinate transmembrane transport	NA	solute carrier family 13 member 3 [Source:HGNC Symbol%3BAcc:HGNC:14430]
ENSG00000145386	48.94	52.28	46.23	54.83	63.90	49.86	-0.182858690704154	6.09634437378057	0.0400523540708777	0.266112716541732	4:121816443-121823933:-	CCNA2	37;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0001939,cellular_component female pronucleus;GO:0001940,cellular_component male pronucleus;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007265,biological_process Ras protein signal transduction;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016572,biological_process histone phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0031100,biological_process organ regeneration;GO:0032355,biological_process response to estradiol;GO:0033762,biological_process response to glucagon;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0044320,biological_process cellular response to leptin stimulus;GO:0044843,biological_process cell cycle G1/S phase transition;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051301,biological_process cell division;GO:0071314,biological_process cellular response to cocaine;GO:0071373,biological_process cellular response to luteinizing hormone stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071456,biological_process cellular response to hypoxia;GO:0071732,biological_process cellular response to nitric oxide;GO:0090102,biological_process cochlea development;GO:0097124,cellular_component cyclin A2-CDK2 complex;GO:0097472,molecular_function cyclin-dependent protein kinase activity;GO:1990314,biological_process cellular response to insulin-like growth factor stimulus	CCNA; cyclin-A; K06627	cyclin A2 [Source:HGNC Symbol%3BAcc:HGNC:1578]
ENSG00000091527	134.20	124.20	139.20	155.23	142.48	144.64	-0.140408000274187	6.79482353136757	0.0400524433182283	0.266112716541732	3:133573729-133590261:+	CDV3	3;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0008283,biological_process cell proliferation	NA	CDV3 homolog [Source:HGNC Symbol%3BAcc:HGNC:26928]
ENSG00000143867	1.06	1.44	1.29	0.38	1.05	0.62	0.884308175281885	-0.132049222336359	0.0400680469843307	0.266112716541732	2:19351484-19358653:-	OSR1	63;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001655,biological_process urogenital system development;GO:0001656,biological_process metanephros development;GO:0001657,biological_process ureteric bud development;GO:0001823,biological_process mesonephros development;GO:0002062,biological_process chondrocyte differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007231,biological_process osmosensory signaling pathway;GO:0007507,biological_process heart development;GO:0008406,biological_process gonad development;GO:0010628,biological_process positive regulation of gene expression;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019898,cellular_component extrinsic component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0023016,biological_process signal transduction by trans-phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030857,biological_process negative regulation of epithelial cell differentiation;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0036023,biological_process embryonic skeletal limb joint morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0042476,biological_process odontogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048389,biological_process intermediate mesoderm development;GO:0048793,biological_process pronephros development;GO:0048863,biological_process stem cell differentiation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0060021,biological_process palate development;GO:0060272,biological_process embryonic skeletal joint morphogenesis;GO:0071300,biological_process cellular response to retinoic acid;GO:0072075,biological_process metanephric mesenchyme development;GO:0072111,biological_process cell proliferation involved in kidney development;GO:0072133,biological_process metanephric mesenchyme morphogenesis;GO:0072143,biological_process mesangial cell development;GO:0072162,biological_process metanephric mesenchymal cell differentiation;GO:0072166,biological_process posterior mesonephric tubule development;GO:0072168,biological_process specification of anterior mesonephric tubule identity;GO:0072169,biological_process specification of posterior mesonephric tubule identity;GO:0072180,biological_process mesonephric duct morphogenesis;GO:0072183,biological_process negative regulation of nephron tubule epithelial cell differentiation;GO:0072184,biological_process renal vesicle progenitor cell differentiation;GO:0072190,biological_process ureter urothelium development;GO:0072207,biological_process metanephric epithelium development;GO:0072208,biological_process metanephric smooth muscle tissue development;GO:0072234,biological_process metanephric nephron tubule development;GO:0072239,biological_process metanephric glomerulus vasculature development;GO:0072259,biological_process metanephric interstitial fibroblast development;GO:0072268,biological_process pattern specification involved in metanephros development;GO:0072498,biological_process embryonic skeletal joint development;GO:0090094,biological_process metanephric cap mesenchymal cell proliferation involved in metanephros development;GO:1905408,biological_process negative regulation of creatine transmembrane transporter activity;GO:2000543,biological_process positive regulation of gastrulation;GO:2000650,biological_process negative regulation of sodium ion transmembrane transporter activity	NA	odd-skipped related transciption factor 1 [Source:HGNC Symbol%3BAcc:HGNC:8111]
ENSG00000103227	5.01	4.49	4.84	4.06	4.37	3.81	0.246503259705527	3.39635258779317	0.0401193683680845	0.266311079974884	16:853633-981318:-	LMF1	15;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006641,biological_process triglyceride metabolic process;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0009306,biological_process protein secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033578,biological_process protein glycosylation in Golgi;GO:0034382,biological_process chylomicron remnant clearance;GO:0051004,biological_process regulation of lipoprotein lipase activity;GO:0051006,biological_process positive regulation of lipoprotein lipase activity;GO:0051604,biological_process protein maturation;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:0090207,biological_process regulation of triglyceride metabolic process	NA	lipase maturation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:14154]
ENSG00000003989	0.57	0.26	0.63	0.81	0.48	1.17	-0.702438730835197	0.717343216191629	0.0401863294898386	0.266511477928225	8:17497087-17570573:+	SLC7A2	32;GO:0000064,molecular_function L-ornithine transmembrane transporter activity;GO:0002537,biological_process nitric oxide production involved in inflammatory response;GO:0003333,biological_process amino acid transmembrane transport;GO:0005289,molecular_function high-affinity arginine transmembrane transporter activity;GO:0005292,molecular_function high-affinity lysine transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015174,molecular_function basic amino acid transmembrane transporter activity;GO:0015181,molecular_function arginine transmembrane transporter activity;GO:0015189,molecular_function L-lysine transmembrane transporter activity;GO:0015809,biological_process arginine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0042116,biological_process macrophage activation;GO:0043030,biological_process regulation of macrophage activation;GO:0050727,biological_process regulation of inflammatory response;GO:0061459,molecular_function L-arginine transmembrane transporter activity;GO:0097626,molecular_function low-affinity L-arginine transmembrane transporter activity;GO:0097627,molecular_function high-affinity L-ornithine transmembrane transporter activity;GO:0097638,biological_process L-arginine import across plasma membrane;GO:0097639,biological_process L-lysine import across plasma membrane;GO:0097640,biological_process L-ornithine import across plasma membrane;GO:1902023,biological_process L-arginine transport;GO:1903352,biological_process L-ornithine transmembrane transport;GO:1903826,biological_process arginine transmembrane transport;GO:1990822,biological_process basic amino acid transmembrane transport	NA	solute carrier family 7 member 2 [Source:HGNC Symbol%3BAcc:HGNC:11060]
ENSG00000111358	23.73	23.26	21.46	30.02	25.48	23.97	-0.203688568536742	4.65540197618374	0.0401924987256615	0.266511477928225	12:123633738-123662606:+	GTF2H3	38;GO:0000438,cellular_component core TFIIH complex portion of holo TFIIH complex;GO:0000439,cellular_component core TFIIH complex;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003684,molecular_function damaged DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005675,cellular_component holo TFIIH complex;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006412,biological_process translation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0070816,biological_process phosphorylation of RNA polymerase II C-terminal domain;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0097550,cellular_component transcriptional preinitiation complex	TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3; K03143	general transcription factor IIH subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:4657]
ENSG00000105438	338.36	351.68	341.41	315.25	319.77	321.68	0.119882620493189	7.86557434228592	0.0402154540724197	0.266521319487958	19:48382569-48391553:-	KDELR1	24;GO:0000139,cellular_component Golgi membrane;GO:0002369,biological_process T cell cytokine production;GO:0005046,molecular_function KDEL sequence binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006621,biological_process protein retention in ER lumen;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0030217,biological_process T cell differentiation;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0046923,molecular_function ER retention sequence binding;GO:0070231,biological_process T cell apoptotic process	KDELR; ER lumen protein retaining receptor; K10949	KDEL endoplasmic reticulum protein retention receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:6304]
ENSG00000114316	11.41	12.55	13.21	13.76	13.96	13.88	-0.151714499432828	5.53869425454324	0.0403180038248018	0.266918297433283	3:49277830-49340712:-	USP4	21;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031647,biological_process regulation of protein stability;GO:0031685,molecular_function adenosine receptor binding;GO:0034394,biological_process protein localization to cell surface;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	NA	ubiquitin specific peptidase 4 [Source:HGNC Symbol%3BAcc:HGNC:12627]
ENSG00000011566	16.79	15.57	15.90	15.21	14.06	14.75	0.146588688781923	5.38907057182558	0.040325662839175	0.266918297433283	2:39249265-39437312:-	MAP4K3	20;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007254,biological_process JNK cascade;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0009411,biological_process response to UV;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0034612,biological_process response to tumor necrosis factor;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process	MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]; K04406	mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:6865]
ENSG00000099797	135.15	144.36	139.15	123.16	138.15	120.39	0.144593321494825	7.12075404480078	0.0403398635289486	0.266918297433283	19:14517084-14565980:+	TECR	18;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0017099,molecular_function very-long-chain-acyl-CoA dehydrogenase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030497,biological_process fatty acid elongation;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0055114,biological_process oxidation-reduction process	TER, TSC13, CER10; very-long-chain enoyl-CoA reductase [EC:1.3.1.93]; K10258	trans-2%2C3-enoyl-CoA reductase [Source:HGNC Symbol%3BAcc:HGNC:4551]
ENSG00000151812	0.97	1.65	2.15	0.94	1.17	1.05	0.596688856675593	1.23004151499145	0.0404480088550281	0.267380118663723	14:57563921-57982194:-	SLC35F4	3;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member F4 [Source:HGNC Symbol%3BAcc:HGNC:19845]
ENSG00000170421	248.61	238.36	235.06	266.07	265.34	259.10	-0.11889800635497	8.84072211395998	0.0404527400991277	0.267380118663723	12:52897186-52949954:-	KRT8	30;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0005911,cellular_component cell-cell junction;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016032,biological_process viral process;GO:0016327,cellular_component apicolateral plasma membrane;GO:0016363,cellular_component nuclear matrix;GO:0030018,cellular_component Z disc;GO:0031424,biological_process keratinization;GO:0032403,molecular_function protein complex binding;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0045095,cellular_component keratin filament;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045214,biological_process sarcomere organization;GO:0051599,biological_process response to hydrostatic pressure;GO:0051707,biological_process response to other organism;GO:0060706,biological_process cell differentiation involved in embryonic placenta development;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0071944,cellular_component cell periphery;GO:0097110,molecular_function scaffold protein binding;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097284,biological_process hepatocyte apoptotic process	NA	keratin 8 [Source:HGNC Symbol%3BAcc:HGNC:6446]
ENSG00000116830	7.09	7.68	7.07	7.54	8.31	9.12	-0.186278638684386	4.77450856639575	0.0405582128976701	0.267800865894449	1:117060302-117107453:+	TTF2	19;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0008023,cellular_component transcription elongation factor complex;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016787,molecular_function hydrolase activity	TTF2; transcription termination factor 2 [EC:3.6.4.-]; K15173	transcription termination factor 2 [Source:HGNC Symbol%3BAcc:HGNC:12398]
ENSG00000137343	0.41	0.28	0.81	1.32	0.89	0.57	-0.818287849507382	0.188480152762569	0.0405595446613683	0.267800865894449	6:30626841-30646823:+	ATAT1	27;GO:0004468,molecular_function lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005905,cellular_component clathrin-coated pit;GO:0005925,cellular_component focal adhesion;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019799,molecular_function tubulin N-acetyltransferase activity;GO:0021542,biological_process dentate gyrus development;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0042995,cellular_component cell projection;GO:0045598,biological_process regulation of fat cell differentiation;GO:0048666,biological_process neuron development;GO:0050662,molecular_function coenzyme binding;GO:0060271,biological_process cilium morphogenesis;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0071929,biological_process alpha-tubulin acetylation;GO:0072686,cellular_component mitotic spindle;GO:0097427,cellular_component microtubule bundle;GO:1900227,biological_process positive regulation of NLRP3 inflammasome complex assembly	NA	alpha tubulin acetyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:21186]
ENSG00000119636	4.34	4.58	5.52	6.26	5.88	5.58	-0.278457976838207	3.1535617453679	0.0406454384026773	0.268225319985345	14:74019352-74082863:+	BBOF1	6;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly	NA	basal body orientation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:19855]
ENSG00000110002	5.22	5.52	6.82	7.59	6.65	6.75	-0.242391680762593	3.96928991519811	0.0408008061836556	0.268966210978339	11:124115361-124147721:+	VWA5A	NA	NA	von Willebrand factor A domain containing 5A [Source:HGNC Symbol%3BAcc:HGNC:6658]
ENSG00000137460	1.03	1.25	1.01	0.85	0.77	0.84	0.411306997766243	1.77042623648292	0.0408010452970444	0.268966210978339	4:152936351-152979696:+	FHDC1	NA	NA	FH2 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29363]
ENSG00000172432	59.08	42.99	59.41	73.74	51.14	71.61	-0.270218578361967	7.03015948457813	0.040937602735325	0.26972317555923	6:43605315-43629162:-	GTPBP2	9;GO:0000166,molecular_function nucleotide binding;GO:0002576,biological_process platelet degranulation;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0008150,biological_process biological_process;GO:0031093,cellular_component platelet alpha granule lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	GTP binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4670]
ENSG00000135900	44.32	40.87	39.09	45.40	45.69	47.87	-0.148329152128429	5.45683394154878	0.0410029255370698	0.269863619176922	2:223957403-223967714:+	MRPL44	20;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004525,molecular_function ribonuclease III activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0006396,biological_process RNA processing;GO:0016787,molecular_function hydrolase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	mitochondrial ribosomal protein L44 [Source:HGNC Symbol%3BAcc:HGNC:16650]
ENSG00000111196	48.11	49.46	50.99	57.75	51.28	58.93	-0.166569241198932	4.99104689302906	0.0410146913642673	0.269863619176922	12:10604189-10613623:-	MAGOHB	17;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0031124,biological_process mRNA 3'-end processing;GO:0035145,cellular_component exon-exon junction complex;GO:0043025,cellular_component neuronal cell body;GO:0051028,biological_process mRNA transport;GO:0071013,cellular_component catalytic step 2 spliceosome	MAGOH; protein mago nashi; K12877	mago homolog B%2C exon junction complex core component [Source:HGNC Symbol%3BAcc:HGNC:25504]
ENSG00000168884	27.27	25.54	23.73	27.98	28.11	30.11	-0.159610946919075	5.13415954761455	0.0410241399651052	0.269863619176922	4:2741647-2756376:-	TNIP2	26;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0016579,biological_process protein deubiquitination;GO:0019901,molecular_function protein kinase binding;GO:0023035,biological_process CD40 signaling pathway;GO:0031593,molecular_function polyubiquitin binding;GO:0034134,biological_process toll-like receptor 2 signaling pathway;GO:0034138,biological_process toll-like receptor 3 signaling pathway;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0043032,biological_process positive regulation of macrophage activation;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0050871,biological_process positive regulation of B cell activation;GO:0051403,biological_process stress-activated MAPK cascade;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	NA	TNFAIP3 interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:19118]
ENSG00000141425	19.63	17.32	19.04	21.46	19.89	22.91	-0.1824886880868	4.538682902822	0.0411062924333896	0.270260809309145	18:35984386-36067576:-	RPRD1A	5;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0070940,biological_process dephosphorylation of RNA polymerase II C-terminal domain	NA	regulation of nuclear pre-mRNA domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:25560]
ENSG00000112659	7.33	7.21	7.04	6.60	6.83	6.37	0.13641453757549	5.70712184588615	0.0411987916085101	0.270725569209336	6:43182174-43224587:+	CUL9	13;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0016567,biological_process protein ubiquitination;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	cullin 9 [Source:HGNC Symbol%3BAcc:HGNC:15982]
ENSG00000182831	41.14	39.32	40.59	46.48	44.00	44.66	-0.145033666482343	5.16629792528865	0.0412723666599255	0.271065548862251	16:9091647-9121640:+	C16orf72	1;GO:0005515,molecular_function protein binding	NA	chromosome 16 open reading frame 72 [Source:HGNC Symbol%3BAcc:HGNC:30103]
ENSG00000196228	1.39	1.89	0.89	0.66	1.08	0.62	0.801322642575867	0.158103037337038	0.041312943881114	0.271188562874811	2:108247194-108265351:+	SULT1C3	6;GO:0004027,molecular_function alcohol sulfotransferase activity;GO:0004062,molecular_function aryl sulfotransferase activity;GO:0005737,cellular_component cytoplasm;GO:0006790,biological_process sulfur compound metabolic process;GO:0008146,molecular_function sulfotransferase activity;GO:0016740,molecular_function transferase activity	NA	sulfotransferase family 1C member 3 [Source:HGNC Symbol%3BAcc:HGNC:33543]
ENSG00000165028	0.57	1.55	2.38	0.81	0.72	0.85	0.909329573207036	-0.0165735080523077	0.0413359129251071	0.271195923435177	9:104764156-104777457:+	NIPSNAP3B	1;GO:0005739,cellular_component mitochondrion	NA	nipsnap homolog 3B [Source:HGNC Symbol%3BAcc:HGNC:23641]
ENSG00000164506	8.63	7.36	8.14	7.14	7.38	7.12	0.175187177622951	4.76750996520409	0.041405113407431	0.271506430389034	6:147204424-147390476:+	STXBP5	25;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005892,cellular_component acetylcholine-gated channel complex;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0010468,biological_process regulation of gene expression;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017075,molecular_function syntaxin-1 binding;GO:0017137,molecular_function Rab GTPase binding;GO:0017157,biological_process regulation of exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030193,biological_process regulation of blood coagulation;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0045921,biological_process positive regulation of exocytosis;GO:0050708,biological_process regulation of protein secretion	NA	syntaxin binding protein 5 [Source:HGNC Symbol%3BAcc:HGNC:19665]
ENSG00000241119	2.00	1.44	2.13	1.22	1.62	1.19	0.497699255645014	1.43832870599157	0.0414391497444819	0.271586148774157	2:233671852-233773300:+	UGT1A9	21;GO:0001972,molecular_function retinoic acid binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0019216,biological_process regulation of lipid metabolic process;GO:0042573,biological_process retinoic acid metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046982,molecular_function protein heterodimerization activity;GO:0051552,biological_process flavone metabolic process;GO:0052695,biological_process cellular glucuronidation;GO:0052696,biological_process flavonoid glucuronidation;GO:0052697,biological_process xenobiotic glucuronidation;GO:0070062,cellular_component extracellular exosome	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 1 member A9 [Source:HGNC Symbol%3BAcc:HGNC:12541]
ENSG00000132274	2.96	4.25	3.65	4.29	4.98	4.44	-0.341692312037907	2.69838714284115	0.0414942015816745	0.27180344286719	11:5689688-5737089:+	TRIM22	31;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006955,biological_process immune response;GO:0008270,molecular_function zinc ion binding;GO:0009615,biological_process response to virus;GO:0010508,biological_process positive regulation of autophagy;GO:0015030,cellular_component Cajal body;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030674,molecular_function protein binding, bridging;GO:0032880,biological_process regulation of protein localization;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070206,biological_process protein trimerization;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	tripartite motif containing 22 [Source:HGNC Symbol%3BAcc:HGNC:16379]
ENSG00000198899	8721.77	9327.93	8935.81	8125.71	8717.18	8121.64	0.124100166066238	12.5205464178916	0.0415356250220033	0.271824507040735	MT:8526-9207:+	MT-ATP6	19;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007568,biological_process aging;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0055093,biological_process response to hyperoxia;GO:0070062,cellular_component extracellular exosome	ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a; K02126	mitochondrially encoded ATP synthase 6 [Source:HGNC Symbol%3BAcc:HGNC:7414]
ENSG00000117899	37.29	41.62	36.40	32.77	34.99	35.84	0.160458303964427	5.08842728578074	0.0415412140382078	0.271824507040735	15:80946288-80989878:-	MESD	9;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007498,biological_process mesoderm development;GO:0016055,biological_process Wnt signaling pathway;GO:0034394,biological_process protein localization to cell surface;GO:0050750,molecular_function low-density lipoprotein particle receptor binding	NA	mesoderm development LRP chaperone [Source:HGNC Symbol%3BAcc:HGNC:13520]
ENSG00000092931	10.17	10.96	10.51	9.06	8.98	9.78	0.192123426316613	4.00179555609684	0.0417804000010467	0.273245577035296	17:76735864-76781449:+	MFSD11	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	major facilitator superfamily domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:25458]
ENSG00000185686	16.55	16.27	16.46	14.28	15.45	14.81	0.158767245205641	4.79189918433848	0.0418251986696078	0.273260520292168	22:22547700-22559361:-	PRAME	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0040008,biological_process regulation of growth;GO:0042974,molecular_function retinoic acid receptor binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048387,biological_process negative regulation of retinoic acid receptor signaling pathway	NA	preferentially expressed antigen in melanoma [Source:HGNC Symbol%3BAcc:HGNC:9336]
ENSG00000166987	11.50	11.85	12.18	10.59	11.15	10.57	0.148563428441749	5.10920780997553	0.041865909434172	0.273260520292168	12:57520709-57530148:+	MBD6	8;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0010369,cellular_component chromocenter;GO:0016579,biological_process protein deubiquitination	NA	methyl-CpG binding domain protein 6 [Source:HGNC Symbol%3BAcc:HGNC:20445]
ENSG00000130827	16.97	16.34	18.62	16.47	15.90	14.92	0.148415148683976	6.54019013843661	0.0418957069462975	0.273260520292168	X:154458280-154477779:+	PLXNA3	26;GO:0002116,cellular_component semaphorin receptor complex;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0021612,biological_process facial nerve structural organization;GO:0021637,biological_process trigeminal nerve structural organization;GO:0021766,biological_process hippocampus development;GO:0021785,biological_process branchiomotor neuron axon guidance;GO:0021860,biological_process pyramidal neuron development;GO:0030054,cellular_component cell junction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048841,biological_process regulation of axon extension involved in axon guidance;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0050919,biological_process negative chemotaxis;GO:0051495,biological_process positive regulation of cytoskeleton organization;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0097485,biological_process neuron projection guidance;GO:1902287,biological_process semaphorin-plexin signaling pathway involved in axon guidance;GO:1990138,biological_process neuron projection extension	PLXNA; plexin A; K06820	plexin A3 [Source:HGNC Symbol%3BAcc:HGNC:9101]
ENSG00000197782	5.30	6.62	5.98	7.04	6.85	7.12	-0.231275385363843	3.77767222033477	0.0419015481696466	0.273260520292168	19:40069151-40090938:-	ZNF780A	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 780A [Source:HGNC Symbol%3BAcc:HGNC:27603]
ENSG00000167080	1.28	1.51	1.50	1.01	1.11	0.90	0.513220654308289	1.14954453788326	0.0419297540511716	0.273260520292168	17:49132459-49176840:+	B4GALNT2	15;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006047,biological_process UDP-N-acetylglucosamine metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0019276,biological_process UDP-N-acetylgalactosamine metabolic process;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030259,biological_process lipid glycosylation	NA	beta-1%2C4-N-acetyl-galactosaminyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:24136]
ENSG00000169432	10.85	8.69	11.31	12.12	10.59	12.95	-0.193456182529437	6.0767456409836	0.0419299847387686	0.273260520292168	2:166195184-166375993:-	SCN9A	26;GO:0001518,cellular_component voltage-gated sodium channel complex;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005248,molecular_function voltage-gated sodium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006954,biological_process inflammatory response;GO:0009636,biological_process response to toxic substance;GO:0009791,biological_process post-embryonic development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019228,biological_process neuronal action potential;GO:0019233,biological_process sensory perception of pain;GO:0031402,molecular_function sodium ion binding;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042995,cellular_component cell projection;GO:0048266,biological_process behavioral response to pain;GO:0055085,biological_process transmembrane transport;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0086010,biological_process membrane depolarization during action potential	SCN9A, NAV1.7; voltage-gated sodium channel type IX alpha; K04841	sodium voltage-gated channel alpha subunit 9 [Source:HGNC Symbol%3BAcc:HGNC:10597]
ENSG00000183979	5.13	5.10	3.93	3.20	3.89	2.70	0.540369845064861	1.00203611396702	0.0419367833043245	0.273260520292168	17:81900744-81902905:+	NPB	5;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway	NPB; preproneuropeptide B; K05267	neuropeptide B [Source:HGNC Symbol%3BAcc:HGNC:30099]
ENSG00000213759	1.11	0.96	1.16	1.60	1.62	1.46	-0.508322820151654	1.18023437864157	0.0419972225324129	0.273510767730767	4:69199950-69214731:-	UGT2B11	13;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 2 member B11 [Source:HGNC Symbol%3BAcc:HGNC:12545]
ENSG00000152784	1.09	0.79	1.25	0.91	0.26	0.82	0.677495240054288	0.944489414786152	0.0420366749705604	0.27362414599348	4:80183878-80204329:+	PRDM8	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0008168,molecular_function methyltransferase activity;GO:0014003,biological_process oligodendrocyte development;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	PR/SET domain 8 [Source:HGNC Symbol%3BAcc:HGNC:13993]
ENSG00000214575	4.00	3.71	3.83	2.43	3.88	2.92	0.338072713579045	2.94855026620889	0.0420810910403958	0.27376969763335	15:82543200-82648861:-	CPEB1	42;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005886,cellular_component plasma membrane;GO:0006397,biological_process mRNA processing;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043022,molecular_function ribosome binding;GO:0043025,cellular_component neuronal cell body;GO:0045182,molecular_function translation regulator activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045727,biological_process positive regulation of translation;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051028,biological_process mRNA transport;GO:0051770,biological_process positive regulation of nitric-oxide synthase biosynthetic process;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:1990124,cellular_component messenger ribonucleoprotein complex;GO:2000766,biological_process negative regulation of cytoplasmic translation	CPEB, ORB; cytoplasmic polyadenylation element-binding protein; K02602	cytoplasmic polyadenylation element binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21744]
ENSG00000170345	0.99	1.19	1.32	0.70	0.41	1.04	0.688636552397139	0.438990821106413	0.0422336812665329	0.274618483793333	14:75278773-75282230:+	FOS	64;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001661,biological_process conditioned taste aversion;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006306,biological_process DNA methylation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0008134,molecular_function transcription factor binding;GO:0009409,biological_process response to cold;GO:0009416,biological_process response to light stimulus;GO:0009612,biological_process response to mechanical stimulus;GO:0009629,biological_process response to gravity;GO:0009636,biological_process response to toxic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0030431,biological_process sleep;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032496,biological_process response to lipopolysaccharide;GO:0032570,biological_process response to progesterone;GO:0032870,biological_process cellular response to hormone stimulus;GO:0032993,cellular_component protein-DNA complex;GO:0034097,biological_process response to cytokine;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035902,biological_process response to immobilization stress;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0035976,cellular_component AP1 complex;GO:0035994,biological_process response to muscle stretch;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042493,biological_process response to drug;GO:0043005,cellular_component neuron projection;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051412,biological_process response to corticosterone;GO:0051591,biological_process response to cAMP;GO:0060395,biological_process SMAD protein signal transduction;GO:0070412,molecular_function R-SMAD binding;GO:0071276,biological_process cellular response to cadmium ion;GO:0071277,biological_process cellular response to calcium ion;GO:1901216,biological_process positive regulation of neuron death;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter	FOS; proto-oncogene protein c-fos; K04379	Fos proto-oncogene%2C AP-1 transcription factor subunit [Source:HGNC Symbol%3BAcc:HGNC:3796]
ENSG00000136295	53.93	57.07	53.38	56.08	66.52	61.12	-0.149566000168222	6.79007778591286	0.0422963120539535	0.274793940732328	7:2631950-2664802:+	TTYH3	12;GO:0005229,molecular_function intracellular calcium activated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0034707,cellular_component chloride channel complex;GO:0070062,cellular_component extracellular exosome;GO:1902476,biological_process chloride transmembrane transport	NA	tweety family member 3 [Source:HGNC Symbol%3BAcc:HGNC:22222]
ENSG00000069011	9.51	8.84	8.42	6.62	7.38	8.50	0.260741090802975	3.36095305400765	0.0423169383367759	0.274793940732328	5:135027734-135034813:-	PITX1	26;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0014707,biological_process branchiomeric skeletal muscle development;GO:0021983,biological_process pituitary gland development;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035137,biological_process hindlimb morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048625,biological_process myoblast fate commitment;GO:0051216,biological_process cartilage development	NA	paired like homeodomain 1 [Source:HGNC Symbol%3BAcc:HGNC:9004]
ENSG00000152942	12.65	14.30	16.13	16.16	16.69	16.45	-0.183589762824907	5.02273379950131	0.0423270776347548	0.274793940732328	5:69369292-69414801:+	RAD17	22;GO:0000076,biological_process DNA replication checkpoint;GO:0000077,biological_process DNA damage checkpoint;GO:0000166,molecular_function nucleotide binding;GO:0000781,cellular_component chromosome, telomeric region;GO:0000790,cellular_component nuclear chromatin;GO:0003682,molecular_function chromatin binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0008156,biological_process negative regulation of DNA replication;GO:0031389,cellular_component Rad17 RFC-like complex;GO:0033314,biological_process mitotic DNA replication checkpoint;GO:0042325,biological_process regulation of phosphorylation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	RAD17 checkpoint clamp loader component [Source:HGNC Symbol%3BAcc:HGNC:9807]
ENSG00000175764	2.14	1.85	1.61	1.63	1.38	1.31	0.389741380324541	2.08164912943288	0.0424422112429288	0.275397369659423	9:121821927-122093606:-	TTLL11	13;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0006464,biological_process cellular protein modification process;GO:0016874,molecular_function ligase activity;GO:0018095,biological_process protein polyglutamylation;GO:0042995,cellular_component cell projection;GO:0051013,biological_process microtubule severing;GO:0070740,molecular_function tubulin-glutamic acid ligase activity	NA	tubulin tyrosine ligase like 11 [Source:HGNC Symbol%3BAcc:HGNC:18113]
ENSG00000111670	12.15	14.70	12.46	13.24	17.21	15.00	-0.200978150199581	5.80619986320254	0.0424778555745765	0.275444900099347	12:101745496-101830938:-	GNPTAB	15;GO:0000139,cellular_component Golgi membrane;GO:0003976,molecular_function UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0007040,biological_process lysosome organization;GO:0009306,biological_process protein secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016256,biological_process N-glycan processing to lysosome;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0033299,biological_process secretion of lysosomal enzymes;GO:0046835,biological_process carbohydrate phosphorylation;GO:0046872,molecular_function metal ion binding	GNPTAB; UDP-N-acetylglucosamine-lysosomal-enzyme [EC:2.7.8.17]; K08239	N-acetylglucosamine-1-phosphate transferase alpha and beta subunits [Source:HGNC Symbol%3BAcc:HGNC:29670]
ENSG00000131871	26.94	28.93	28.46	24.53	24.55	25.90	0.177131737761067	4.34945540327154	0.0425577328800521	0.275444900099347	15:101270816-101277500:-	SELENOS	43;GO:0002865,biological_process negative regulation of acute inflammatory response to antigenic stimulus;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006886,biological_process intracellular protein transport;GO:0006983,biological_process ER overload response;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016209,molecular_function antioxidant activity;GO:0016567,biological_process protein ubiquitination;GO:0019899,molecular_function enzyme binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034361,cellular_component very-low-density lipoprotein particle;GO:0034362,cellular_component low-density lipoprotein particle;GO:0034599,biological_process cellular response to oxidative stress;GO:0036502,cellular_component Derlin-1-VIMP complex;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0045184,biological_process establishment of protein localization;GO:0045454,biological_process cell redox homeostasis;GO:0045719,biological_process negative regulation of glycogen biosynthetic process;GO:0046325,biological_process negative regulation of glucose import;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051117,molecular_function ATPase binding;GO:0051771,biological_process negative regulation of nitric-oxide synthase biosynthetic process;GO:0051775,biological_process response to redox state;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0080164,biological_process regulation of nitric oxide metabolic process;GO:0098869,biological_process cellular oxidant detoxification;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1990381,molecular_function ubiquitin-specific protease binding;GO:2000110,biological_process negative regulation of macrophage apoptotic process	SELS, VIMP; selenoprotein S; K14025	selenoprotein S [Source:HGNC Symbol%3BAcc:HGNC:30396]
ENSG00000081177	16.91	15.85	16.28	18.09	18.08	18.72	-0.148487054341339	5.02162678026384	0.0425650162180612	0.275444900099347	14:69191510-69244020:+	EXD2	15;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006302,biological_process double-strand break repair;GO:0008310,molecular_function single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0008852,molecular_function exodeoxyribonuclease I activity;GO:0016787,molecular_function hydrolase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	exonuclease 3'-5' domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20217]
ENSG00000149577	10.98	11.20	10.58	9.88	10.50	8.85	0.175867527956534	4.77399857230622	0.0425686044860955	0.275444900099347	11:117178732-117197445:+	SIDT2	13;GO:0000902,biological_process cell morphogenesis;GO:0003323,biological_process type B pancreatic cell development;GO:0003725,molecular_function double-stranded RNA binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033227,biological_process dsRNA transport;GO:0042593,biological_process glucose homeostasis;GO:0044342,biological_process type B pancreatic cell proliferation;GO:0051033,molecular_function RNA transmembrane transporter activity;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus	NA	SID1 transmembrane family member 2 [Source:HGNC Symbol%3BAcc:HGNC:24272]
ENSG00000100239	20.72	21.92	19.97	18.59	19.74	19.03	0.135400758271785	5.86267894326605	0.0425992324944341	0.275444900099347	22:50343303-50445090:+	PPP6R2	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	protein phosphatase 6 regulatory subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:19253]
ENSG00000151892	12.05	15.28	11.34	15.24	15.49	14.62	-0.229636230700512	4.29556348925005	0.042604440845443	0.275444900099347	10:116056924-116273467:-	GFRA1	16;GO:0000165,biological_process MAPK cascade;GO:0004872,molecular_function receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016167,molecular_function glial cell-derived neurotrophic factor receptor activity;GO:0019898,cellular_component extrinsic component of membrane;GO:0031225,cellular_component anchored component of membrane;GO:0035860,biological_process glial cell-derived neurotrophic factor receptor signaling pathway;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070062,cellular_component extracellular exosome	NA	GDNF family receptor alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:4243]
ENSG00000173918	17.26	14.85	17.81	14.03	10.35	16.52	0.301599045364768	3.69528840993482	0.0426166921233965	0.275444900099347	17:79022813-79049788:+	C1QTNF1	18;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0010544,biological_process negative regulation of platelet activation;GO:0010628,biological_process positive regulation of gene expression;GO:0010906,biological_process regulation of glucose metabolic process;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0051260,biological_process protein homooligomerization;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070208,biological_process protein heterotrimerization;GO:0090331,biological_process negative regulation of platelet aggregation;GO:2000860,biological_process positive regulation of aldosterone secretion	NA	C1q and TNF related 1 [Source:HGNC Symbol%3BAcc:HGNC:14324]
ENSG00000197283	6.06	6.12	6.87	5.94	5.58	5.50	0.176576559827784	4.70396353905367	0.0426497584078717	0.275444900099347	6:33419660-33457541:+	SYNGAP1	24;GO:0000165,biological_process MAPK cascade;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0007389,biological_process pattern specification process;GO:0008542,biological_process visual learning;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016358,biological_process dendrite development;GO:0017124,molecular_function SH3 domain binding;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0043087,biological_process regulation of GTPase activity;GO:0043113,biological_process receptor clustering;GO:0043198,cellular_component dendritic shaft;GO:0043408,biological_process regulation of MAPK cascade;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050803,biological_process regulation of synapse structure or activity	NA	synaptic Ras GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11497]
ENSG00000179241	1.23	1.41	1.47	2.27	2.24	1.53	-0.541303564959865	1.07229410941506	0.0426537532057549	0.275444900099347	11:35943980-36232136:+	LDLRAD3	6;GO:0001540,molecular_function beta-amyloid binding;GO:0005886,cellular_component plasma membrane;GO:0006898,biological_process receptor-mediated endocytosis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070613,biological_process regulation of protein processing	NA	low density lipoprotein receptor class A domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:27046]
ENSG00000153815	26.84	28.27	29.75	32.26	30.48	31.26	-0.13597364019137	6.2129885706544	0.04267143663023	0.275444900099347	16:81445169-81711762:+	CMIP	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	c-Maf inducing protein [Source:HGNC Symbol%3BAcc:HGNC:24319]
ENSG00000198399	8.93	8.29	8.84	7.53	7.67	8.50	0.150018453677279	5.45612589674154	0.0427549732672729	0.275840687716558	2:24202863-24360714:-	ITSN2	14;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006897,biological_process endocytosis;GO:0009967,biological_process positive regulation of signal transduction;GO:0030154,biological_process cell differentiation;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1903861,biological_process positive regulation of dendrite extension	NA	intersectin 2 [Source:HGNC Symbol%3BAcc:HGNC:6184]
ENSG00000110844	15.79	14.16	17.47	18.25	17.27	18.11	-0.160784062900946	5.50460780188269	0.0427986020118382	0.275856576143798	12:49568217-49644666:+	PRPF40B	8;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005685,cellular_component U1 snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0071004,cellular_component U2-type prespliceosome	PRPF40, PRP40; pre-mRNA-processing factor 40; K12821	pre-mRNA processing factor 40 homolog B [Source:HGNC Symbol%3BAcc:HGNC:25031]
ENSG00000170915	7.51	6.57	9.22	11.14	7.28	12.05	-0.36996745906903	3.28691883189679	0.0428329329307819	0.275856576143798	6:52361420-52407777:+	PAQR8	12;GO:0003707,molecular_function steroid hormone receptor activity;GO:0005496,molecular_function steroid binding;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0048477,biological_process oogenesis;GO:0048545,biological_process response to steroid hormone	NA	progestin and adipoQ receptor family member 8 [Source:HGNC Symbol%3BAcc:HGNC:15708]
ENSG00000196455	9.88	11.38	9.09	8.47	9.33	9.18	0.175439726404798	5.28475406347792	0.0428493630211134	0.275856576143798	3:130678934-130746829:-	PIK3R4	36;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005643,cellular_component nuclear pore;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006468,biological_process protein phosphorylation;GO:0006623,biological_process protein targeting to vacuole;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030242,biological_process pexophagy;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032465,biological_process regulation of cytokinesis;GO:0032801,biological_process receptor catabolic process;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0034271,cellular_component phosphatidylinositol 3-kinase complex, class III, type I;GO:0034272,cellular_component phosphatidylinositol 3-kinase complex, class III, type II;GO:0035032,cellular_component phosphatidylinositol 3-kinase complex, class III;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0042149,biological_process cellular response to glucose starvation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045324,biological_process late endosome to vacuole transport;GO:0071561,cellular_component nucleus-vacuole junction	PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]; K08333	phosphoinositide-3-kinase regulatory subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:8982]
ENSG00000100714	56.94	62.39	54.11	64.63	67.42	61.18	-0.145159633089602	7.61079796889003	0.0428662334411357	0.275856576143798	14:64388030-64463457:+	MTHFD1	38;GO:0000105,biological_process histidine biosynthetic process;GO:0000166,molecular_function nucleotide binding;GO:0001780,biological_process neutrophil homeostasis;GO:0001843,biological_process neural tube closure;GO:0003824,molecular_function catalytic activity;GO:0004329,molecular_function formate-tetrahydrofolate ligase activity;GO:0004477,molecular_function methenyltetrahydrofolate cyclohydrolase activity;GO:0004486,molecular_function methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity;GO:0004487,molecular_function methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488,molecular_function methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006555,biological_process methionine metabolic process;GO:0006730,biological_process one-carbon metabolic process;GO:0007507,biological_process heart development;GO:0008152,biological_process metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009069,biological_process serine family amino acid metabolic process;GO:0009070,biological_process serine family amino acid biosynthetic process;GO:0009086,biological_process methionine biosynthetic process;GO:0009113,biological_process purine nucleobase biosynthetic process;GO:0009257,biological_process 10-formyltetrahydrofolate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016787,molecular_function hydrolase activity;GO:0016874,molecular_function ligase activity;GO:0019346,biological_process transsulfuration;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0046655,biological_process folic acid metabolic process;GO:0048702,biological_process embryonic neurocranium morphogenesis;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0055114,biological_process oxidation-reduction process;GO:0061053,biological_process somite development;GO:0070062,cellular_component extracellular exosome	MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]; K00288	methylenetetrahydrofolate dehydrogenase%2C cyclohydrolase and formyltetrahydrofolate synthetase 1 [Source:HGNC Symbol%3BAcc:HGNC:7432]
ENSG00000123178	16.22	16.74	16.65	14.01	12.38	15.43	0.253421896693893	3.18586349874984	0.0428685519520975	0.275856576143798	13:49912705-49936490:-	SPRYD7	1;GO:0005515,molecular_function protein binding	NA	SPRY domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:14297]
ENSG00000125107	50.97	51.22	51.29	55.18	55.27	57.05	-0.114323435546874	8.62756453230371	0.0429124177299963	0.275889037399005	16:58519950-58629886:-	CNOT1	34;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007275,biological_process multicellular organism development;GO:0010606,biological_process positive regulation of cytoplasmic mRNA processing body assembly;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0019904,molecular_function protein domain specific binding;GO:0030014,cellular_component CCR4-NOT complex;GO:0030015,cellular_component CCR4-NOT core complex;GO:0030331,molecular_function estrogen receptor binding;GO:0031047,biological_process gene silencing by RNA;GO:0032947,molecular_function protein complex scaffold;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0035195,biological_process gene silencing by miRNA;GO:0042974,molecular_function retinoic acid receptor binding;GO:0048387,biological_process negative regulation of retinoic acid receptor signaling pathway;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0070016,molecular_function armadillo repeat domain binding;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:2000036,biological_process regulation of stem cell population maintenance	CNOT1, NOT1; CCR4-NOT transcription complex subunit 1; K12604	CCR4-NOT transcription complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:7877]
ENSG00000108424	141.84	140.17	134.66	152.60	148.41	154.75	-0.117704825655597	8.66088638214893	0.0429180481122596	0.275889037399005	17:47649475-47685505:+	KPNB1	46;GO:0000060,biological_process protein import into nucleus, translocation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007079,biological_process mitotic chromosome movement towards spindle pole;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008270,molecular_function zinc ion binding;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019054,biological_process modulation by virus of host process;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030953,biological_process astral microtubule organization;GO:0031291,biological_process Ran protein signal transduction;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0035580,cellular_component specific granule lumen;GO:0040001,biological_process establishment of mitotic spindle localization;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043657,cellular_component host cell;GO:0045184,biological_process establishment of protein localization;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0051879,molecular_function Hsp90 protein binding;GO:0070062,cellular_component extracellular exosome;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0075733,biological_process intracellular transport of virus;GO:0090307,biological_process mitotic spindle assembly;GO:1904813,cellular_component ficolin-1-rich granule lumen	KPNB1, IPO1; importin subunit beta-1; K14293	karyopherin subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:6400]
ENSG00000116337	51.76	49.33	54.63	62.02	52.90	59.02	-0.147253225683181	7.36530205440669	0.0431586329049841	0.277291982530832	1:109616103-109632051:+	AMPD2	14;GO:0003876,molecular_function AMP deaminase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0006188,biological_process IMP biosynthetic process;GO:0009117,biological_process nucleotide metabolic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0019239,molecular_function deaminase activity;GO:0032264,biological_process IMP salvage;GO:0043101,biological_process purine-containing compound salvage;GO:0046872,molecular_function metal ion binding;GO:0052652,biological_process cyclic purine nucleotide metabolic process;GO:0097009,biological_process energy homeostasis	AMPD; AMP deaminase [EC:3.5.4.6]; K01490	adenosine monophosphate deaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:469]
ENSG00000130529	4.92	4.98	5.29	4.62	4.66	4.09	0.198404700862456	4.12845750102705	0.0432128588749168	0.277451581008272	19:49157740-49211836:+	TRPM4	51;GO:0000166,molecular_function nucleotide binding;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002407,biological_process dendritic cell chemotaxis;GO:0002724,biological_process regulation of T cell cytokine production;GO:0005216,molecular_function ion channel activity;GO:0005227,molecular_function calcium activated cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010460,biological_process positive regulation of heart rate;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016925,biological_process protein sumoylation;GO:0019722,biological_process calcium-mediated signaling;GO:0030502,biological_process negative regulation of bone mineralization;GO:0034220,biological_process ion transmembrane transport;GO:0034706,cellular_component sodium channel complex;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042310,biological_process vasoconstriction;GO:0042391,biological_process regulation of membrane potential;GO:0043025,cellular_component neuronal cell body;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0055085,biological_process transmembrane transport;GO:0061337,biological_process cardiac conduction;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086045,biological_process membrane depolarization during AV node cell action potential;GO:0086047,biological_process membrane depolarization during Purkinje myocyte cell action potential;GO:0086048,biological_process membrane depolarization during bundle of His cell action potential;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0098655,biological_process cation transmembrane transport;GO:0098719,biological_process sodium ion import across plasma membrane;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential;GO:1903949,biological_process positive regulation of atrial cardiac muscle cell action potential;GO:1904179,biological_process positive regulation of adipose tissue development;GO:1904199,biological_process positive regulation of regulation of vascular smooth muscle cell membrane depolarization	TRPM4; transient receptor potential cation channel subfamily M member 4; K04979	transient receptor potential cation channel subfamily M member 4 [Source:HGNC Symbol%3BAcc:HGNC:17993]
ENSG00000156256	22.40	21.60	21.22	23.14	24.11	24.81	-0.131845611163963	5.82553960406186	0.0432628756755177	0.277451581008272	21:29024628-29054488:+	USP16	34;GO:0000278,biological_process mitotic cell cycle;GO:0003713,molecular_function transcription coactivator activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0010468,biological_process regulation of gene expression;GO:0016569,biological_process covalent chromatin modification;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0035522,biological_process monoubiquitinated histone H2A deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042393,molecular_function histone binding;GO:0043130,molecular_function ubiquitin binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045901,biological_process positive regulation of translational elongation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle;GO:0070537,biological_process histone H2A K63-linked deubiquitination	NA	ubiquitin specific peptidase 16 [Source:HGNC Symbol%3BAcc:HGNC:12614]
ENSG00000204920	9.01	8.17	9.03	7.66	7.12	8.04	0.216008726318236	3.78150194191683	0.0432688951665104	0.277451581008272	19:43967861-43998325:+	ZNF155	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 155 [Source:HGNC Symbol%3BAcc:HGNC:12940]
ENSG00000105662	11.79	12.43	11.23	10.85	10.02	10.69	0.174471715095065	4.45473961407098	0.0433002627093318	0.277451581008272	19:18683676-18782333:+	CRTC1	24;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007613,biological_process memory;GO:0008140,molecular_function cAMP response element binding protein binding;GO:0016032,biological_process viral process;GO:0016604,cellular_component nuclear body;GO:0030425,cellular_component dendrite;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0043025,cellular_component neuronal cell body;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0045202,cellular_component synapse;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process;GO:0051289,biological_process protein homotetramerization;GO:0097009,biological_process energy homeostasis;GO:1900006,biological_process positive regulation of dendrite development;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1902631,biological_process negative regulation of membrane hyperpolarization	CRTC1, TORC1; CREB-regulated transcription coactivator 1; K15309	CREB regulated transcription coactivator 1 [Source:HGNC Symbol%3BAcc:HGNC:16062]
ENSG00000116649	32.67	36.71	32.78	30.95	32.01	29.13	0.157081737900478	5.23539607646274	0.043313111195825	0.277451581008272	1:11054583-11060024:-	SRM	11;GO:0003824,molecular_function catalytic activity;GO:0004766,molecular_function spermidine synthase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0008295,biological_process spermidine biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	speE, SRM; spermidine synthase [EC:2.5.1.16]; K00797	spermidine synthase [Source:HGNC Symbol%3BAcc:HGNC:11296]
ENSG00000127418	44.84	41.21	44.83	39.27	39.83	41.39	0.13366433581105	5.99018314006091	0.0433283983277286	0.277451581008272	4:1009935-1026897:+	FGFRL1	17;GO:0001501,biological_process skeletal system development;GO:0003179,biological_process heart valve morphogenesis;GO:0005007,molecular_function fibroblast growth factor-activated receptor activity;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0008201,molecular_function heparin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017134,molecular_function fibroblast growth factor binding;GO:0030133,cellular_component transport vesicle;GO:0044291,cellular_component cell-cell contact zone;GO:0051260,biological_process protein homooligomerization;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060539,biological_process diaphragm development;GO:0098742,biological_process cell-cell adhesion via plasma-membrane adhesion molecules	NA	fibroblast growth factor receptor like 1 [Source:HGNC Symbol%3BAcc:HGNC:3693]
ENSG00000103365	28.88	28.09	28.32	31.55	31.96	30.47	-0.127262195703567	5.961910035067	0.0433399351949601	0.277451581008272	16:23463541-23521995:-	GGA2	17;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030131,cellular_component clathrin adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030306,molecular_function ADP-ribosylation factor binding;GO:0031901,cellular_component early endosome membrane;GO:0044267,biological_process cellular protein metabolic process;GO:0061024,biological_process membrane organization	GGA; ADP-ribosylation factor-binding protein GGA; K12404	golgi associated%2C gamma adaptin ear containing%2C ARF binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16064]
ENSG00000151292	20.93	18.83	18.96	22.41	21.87	21.97	-0.158239441873503	4.8456070715926	0.0435102922909492	0.278398586704924	5:123512098-123617045:+	CSNK1G3	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation	CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]; K08958	casein kinase 1 gamma 3 [Source:HGNC Symbol%3BAcc:HGNC:2456]
ENSG00000171155	32.13	33.96	25.15	25.04	28.94	24.47	0.22609854633392	4.75702008739089	0.0436528105984117	0.279033734798779	X:120625792-120630150:-	C1GALT1C1	11;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016263,molecular_function glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity;GO:0016266,biological_process O-glycan processing;GO:0016267,biological_process O-glycan processing, core 1;GO:0030168,biological_process platelet activation;GO:0036344,biological_process platelet morphogenesis;GO:0070062,cellular_component extracellular exosome	C1GALT2, C1GALT1C1; C1GALT1-specific chaperone 1; K09653	C1GALT1 specific chaperone 1 [Source:HGNC Symbol%3BAcc:HGNC:24338]
ENSG00000184194	4.35	4.70	3.88	3.01	3.66	3.39	0.364267786004714	2.14173612173263	0.0436545164729903	0.279033734798779	X:53049090-53080615:+	GPR173	10;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004968,molecular_function gonadotropin-releasing hormone receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0097211,biological_process cellular response to gonadotropin-releasing hormone;GO:2001223,biological_process negative regulation of neuron migration	NA	G protein-coupled receptor 173 [Source:HGNC Symbol%3BAcc:HGNC:18186]
ENSG00000136478	11.60	11.57	11.16	10.37	10.75	10.25	0.142270351388294	5.22484944508582	0.0437173688738739	0.2792644130449	17:64147226-64263301:-	TEX2	7;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0006665,biological_process sphingolipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	testis expressed 2 [Source:HGNC Symbol%3BAcc:HGNC:30884]
ENSG00000108370	5.19	4.63	4.98	5.96	5.71	5.80	-0.222116868097093	3.51214536246082	0.0437423631395303	0.2792644130449	17:65100811-65227703:+	RGS9	22;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0004871,molecular_function signal transducer activity;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0007601,biological_process visual perception;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0032403,molecular_function protein complex binding;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043627,biological_process response to estrogen;GO:0050896,biological_process response to stimulus;GO:0097381,cellular_component photoreceptor disc membrane	RGS9; regulator of G-protein signaling 9; K13765	regulator of G protein signaling 9 [Source:HGNC Symbol%3BAcc:HGNC:10004]
ENSG00000128284	6.26	3.39	5.61	8.22	4.73	8.32	-0.455250412225167	3.25761229771777	0.0437580990390986	0.2792644130449	22:36140329-36166177:-	APOL3	12;GO:0004871,molecular_function signal transducer activity;GO:0005319,molecular_function lipid transporter activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0042157,biological_process lipoprotein metabolic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling	NA	apolipoprotein L3 [Source:HGNC Symbol%3BAcc:HGNC:14868]
ENSG00000103194	45.99	47.69	46.78	54.84	49.53	50.84	-0.132980033199599	6.98784753682039	0.0437933971800589	0.279346063307334	16:84699977-84779922:+	USP10	28;GO:0002039,molecular_function p53 binding;GO:0003723,molecular_function RNA binding;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006914,biological_process autophagy;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010506,biological_process regulation of autophagy;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019985,biological_process translesion synthesis;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0071347,biological_process cellular response to interleukin-1	NA	ubiquitin specific peptidase 10 [Source:HGNC Symbol%3BAcc:HGNC:12608]
ENSG00000204525	659.87	608.67	636.23	588.38	567.12	609.23	0.122149622250814	9.41621038930567	0.0438529990516151	0.279582576901745	6:31268748-31272130:-	HLA-C	28;GO:0000139,cellular_component Golgi membrane;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019882,biological_process antigen processing and presentation;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031901,cellular_component early endosome membrane;GO:0042605,molecular_function peptide antigen binding;GO:0042612,cellular_component MHC class I protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0050776,biological_process regulation of immune response;GO:0055038,cellular_component recycling endosome membrane;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane	MHC1; MHC class I antigen; K06751	major histocompatibility complex%2C class I%2C C [Source:HGNC Symbol%3BAcc:HGNC:4933]
ENSG00000163349	11.53	10.64	11.90	10.52	10.31	10.28	0.147069087131556	5.34725452166581	0.0438975064701331	0.279722663148748	1:113929191-113977869:+	HIPK1	37;GO:0000166,molecular_function nucleotide binding;GO:0001654,biological_process eye development;GO:0003677,molecular_function DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0007224,biological_process smoothened signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0010842,biological_process retina layer formation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0030182,biological_process neuron differentiation;GO:0034333,biological_process adherens junction assembly;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0060059,biological_process embryonic retina morphogenesis in camera-type eye;GO:0060216,biological_process definitive hemopoiesis;GO:0060235,biological_process lens induction in camera-type eye;GO:0061072,biological_process iris morphogenesis;GO:0072577,biological_process endothelial cell apoptotic process;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]; K08826	homeodomain interacting protein kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:19006]
ENSG00000174780	73.91	72.08	72.92	80.13	76.84	83.65	-0.124439075079568	7.30637822337328	0.0439788732807717	0.279842373459816	4:56466914-56503680:+	SRP72	16;GO:0003723,molecular_function RNA binding;GO:0005047,molecular_function signal recognition particle binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005786,cellular_component signal recognition particle, endoplasmic reticulum targeting;GO:0005829,cellular_component cytosol;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006616,biological_process SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0008312,molecular_function 7S RNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030911,molecular_function TPR domain binding;GO:0042493,biological_process response to drug;GO:0043022,molecular_function ribosome binding;GO:0048500,cellular_component signal recognition particle	SRP72; signal recognition particle subunit SRP72; K03108	signal recognition particle 72 [Source:HGNC Symbol%3BAcc:HGNC:11303]
ENSG00000128789	67.53	66.82	61.79	78.15	69.12	71.27	-0.145003235483232	5.94907953706133	0.0439826975482617	0.279842373459816	18:12658042-12725740:+	PSMG2	8;GO:0000502,cellular_component proteasome complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043248,biological_process proteasome assembly;GO:0051726,biological_process regulation of cell cycle	NA	proteasome assembly chaperone 2 [Source:HGNC Symbol%3BAcc:HGNC:24929]
ENSG00000166411	20.32	20.58	19.40	17.73	17.89	18.35	0.169328437818382	4.42265780995672	0.0439998821500993	0.279842373459816	15:78131497-78171949:+	IDH3A	13;GO:0000287,molecular_function magnesium ion binding;GO:0004449,molecular_function isocitrate dehydrogenase (NAD+) activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0043209,cellular_component myelin sheath;GO:0046872,molecular_function metal ion binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process	IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]; K00030	isocitrate dehydrogenase 3 (NAD(+)) alpha [Source:HGNC Symbol%3BAcc:HGNC:5384]
ENSG00000165626	25.81	23.09	27.40	29.47	27.56	28.94	-0.15526587588748	5.30598238538951	0.0440064700711802	0.279842373459816	10:13438483-13528974:-	BEND7	2;GO:0005515,molecular_function protein binding;GO:0070062,cellular_component extracellular exosome	NA	BEN domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:23514]
ENSG00000172086	99.44	93.60	103.53	110.43	104.64	113.40	-0.133804750507601	6.3436968916514	0.0440682282205042	0.280091611316497	2:88027204-88055729:-	KRCC1	4;GO:0002039,molecular_function p53 binding;GO:0003723,molecular_function RNA binding;GO:0005622,cellular_component intracellular;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	NA	lysine rich coiled-coil 1 [Source:HGNC Symbol%3BAcc:HGNC:28039]
ENSG00000155380	75.00	67.66	70.36	81.11	73.16	82.69	-0.140774137119189	6.81757821007978	0.0442165904910894	0.280890756277325	1:112911846-112957013:-	SLC16A1	30;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006090,biological_process pyruvate metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0007098,biological_process centrosome cycle;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015129,molecular_function lactate transmembrane transporter activity;GO:0015130,molecular_function mevalonate transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0015728,biological_process mevalonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0032094,biological_process response to food;GO:0035873,biological_process lactate transmembrane transport;GO:0035879,biological_process plasma membrane lactate transport;GO:0042593,biological_process glucose homeostasis;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050796,biological_process regulation of insulin secretion;GO:0050900,biological_process leukocyte migration;GO:0051780,biological_process behavioral response to nutrient;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0097159,molecular_function organic cyclic compound binding	NA	solute carrier family 16 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10922]
ENSG00000123600	7.68	7.21	8.00	9.03	9.09	8.99	-0.226631493969181	3.41830264489843	0.0442692290945638	0.280968503558469	2:171317404-171434802:-	METTL8	9;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007519,biological_process skeletal muscle tissue development;GO:0008168,molecular_function methyltransferase activity;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0045444,biological_process fat cell differentiation	NA	methyltransferase like 8 [Source:HGNC Symbol%3BAcc:HGNC:25856]
ENSG00000178462	1.48	1.79	1.16	1.73	2.15	2.36	-0.511072205649041	1.34094242685552	0.0442885418436217	0.280968503558469	10:5393097-5404830:-	TUBAL3	9;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process	TUBA; tubulin alpha; K07374	tubulin alpha like 3 [Source:HGNC Symbol%3BAcc:HGNC:23534]
ENSG00000109971	422.04	584.34	405.00	359.02	468.67	357.94	0.263250884746128	9.71359166883446	0.0442967341870558	0.280968503558469	11:123057488-123063230:-	HSPA8	77;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001786,molecular_function phosphatidylserine binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006457,biological_process protein folding;GO:0006479,biological_process protein methylation;GO:0006986,biological_process response to unfolded protein;GO:0007269,biological_process neurotransmitter secretion;GO:0008380,biological_process RNA splicing;GO:0009267,biological_process cellular response to starvation;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016887,molecular_function ATPase activity;GO:0019899,molecular_function enzyme binding;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0031072,molecular_function heat shock protein binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0034774,cellular_component secretory granule lumen;GO:0042026,biological_process protein refolding;GO:0042470,cellular_component melanosome;GO:0042623,molecular_function ATPase activity, coupled;GO:0043202,cellular_component lysosomal lumen;GO:0043209,cellular_component myelin sheath;GO:0043254,biological_process regulation of protein complex assembly;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0044788,biological_process modulation by host of viral process;GO:0044829,biological_process positive regulation by host of viral genome replication;GO:0045296,molecular_function cadherin binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046034,biological_process ATP metabolic process;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0051082,molecular_function unfolded protein binding;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051726,biological_process regulation of cell cycle;GO:0055131,molecular_function C3HC4-type RING finger domain binding;GO:0061024,biological_process membrane organization;GO:0061202,cellular_component clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0061635,biological_process regulation of protein complex stability;GO:0061684,biological_process chaperone-mediated autophagy;GO:0061738,biological_process late endosomal microautophagy;GO:0061740,biological_process protein targeting to lysosome involved in chaperone-mediated autophagy;GO:0061741,biological_process chaperone-mediated protein transport involved in chaperone-mediated autophagy;GO:0070062,cellular_component extracellular exosome;GO:0072318,biological_process clathrin coat disassembly;GO:0072562,cellular_component blood microparticle;GO:0098575,cellular_component lumenal side of lysosomal membrane;GO:0098793,cellular_component presynapse;GO:1900034,biological_process regulation of cellular response to heat;GO:1902904,biological_process negative regulation of fibril organization;GO:1904589,biological_process regulation of protein import;GO:1904764,biological_process chaperone-mediated autophagy translocation complex disassembly;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	heat shock protein family A (Hsp70) member 8 [Source:HGNC Symbol%3BAcc:HGNC:5241]
ENSG00000280670	4.53	3.76	4.27	2.48	3.30	2.91	0.552194961119956	0.896990580633431	0.0443307763988141	0.281040820959387	1:45493865-45500079:-	CCDC163	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	coiled-coil domain containing 163 [Source:HGNC Symbol%3BAcc:HGNC:27003]
ENSG00000204619	95.66	104.67	93.66	108.54	113.56	106.41	-0.152640414294584	5.29891592148415	0.0443698634972291	0.281145030929609	6:30066708-30070333:+	PPP1R11	8;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0004865,molecular_function protein serine/threonine phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity	NA	protein phosphatase 1 regulatory inhibitor subunit 11 [Source:HGNC Symbol%3BAcc:HGNC:9285]
ENSG00000161999	32.63	38.92	32.72	28.31	33.72	29.54	0.193406032811686	4.80875053186598	0.0446071986352098	0.282244867966219	16:681670-684528:-	JMJD8	1;GO:0070062,cellular_component extracellular exosome	NA	jumonji domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:14148]
ENSG00000165644	8.81	5.84	6.84	4.57	6.27	5.73	0.400231821602543	2.36839126081405	0.0446113443316915	0.282244867966219	10:75233968-75236030:-	COMTD1	8;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0008168,molecular_function methyltransferase activity;GO:0008171,molecular_function O-methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	catechol-O-methyltransferase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26309]
ENSG00000173480	3.93	3.95	3.51	3.02	3.42	2.95	0.290581862357197	2.7349971707147	0.0446116515709113	0.282244867966219	19:57900295-57916610:-	ZNF417	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 417 [Source:HGNC Symbol%3BAcc:HGNC:20646]
ENSG00000244462	29.23	29.33	27.96	23.67	28.29	26.78	0.146847606117577	6.26994869444744	0.0447029303386038	0.282678285426943	20:35648924-35664956:-	RBM12	5;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm	NA	RNA binding motif protein 12 [Source:HGNC Symbol%3BAcc:HGNC:9898]
ENSG00000205542	13262.67	12941.89	12007.02	11669.82	12228.45	11389.40	0.126487540938424	10.6604148682258	0.0447882070705099	0.283073327070387	X:12975107-12977227:+	TMSB4X	28;GO:0001649,biological_process osteoblast differentiation;GO:0002576,biological_process platelet degranulation;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization;GO:0007253,biological_process cytoplasmic sequestering of NF-kappaB;GO:0019899,molecular_function enzyme binding;GO:0031093,cellular_component platelet alpha granule lumen;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042989,biological_process sequestering of actin monomers;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0050727,biological_process regulation of inflammatory response;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling;GO:1901223,biological_process negative regulation of NIK/NF-kappaB signaling;GO:1903026,biological_process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:1905273,biological_process positive regulation of proton-transporting ATP synthase activity, rotational mechanism;GO:2000483,biological_process negative regulation of interleukin-8 secretion;GO:2001028,biological_process positive regulation of endothelial cell chemotaxis;GO:2001171,biological_process positive regulation of ATP biosynthetic process	NA	thymosin beta 4%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:11881]
ENSG00000136052	10.19	10.62	8.82	11.59	11.12	11.45	-0.199355418905781	4.20411728631615	0.0448375561852149	0.283198435012063	12:104802552-104958744:-	SLC41A2	14;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0070838,biological_process divalent metal ion transport;GO:0072509,molecular_function divalent inorganic cation transmembrane transporter activity;GO:0098655,biological_process cation transmembrane transport;GO:1903830,biological_process magnesium ion transmembrane transport	NA	solute carrier family 41 member 2 [Source:HGNC Symbol%3BAcc:HGNC:31045]
ENSG00000141219	14.57	12.62	12.63	15.89	14.54	15.00	-0.173767915572149	4.7261838036492	0.0448536311313716	0.283198435012063	17:73232232-73248947:+	C17orf80	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	chromosome 17 open reading frame 80 [Source:HGNC Symbol%3BAcc:HGNC:29601]
ENSG00000129514	0.58	0.72	0.86	0.41	0.47	0.34	0.831786933481078	-0.054271838671313	0.0449190891961468	0.283467541531149	14:37589983-37596059:-	FOXA1	54;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005902,cellular_component microvillus;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010468,biological_process regulation of gene expression;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0016569,biological_process covalent chromatin modification;GO:0019904,molecular_function protein domain specific binding;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0030324,biological_process lung development;GO:0032355,biological_process response to estradiol;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0035239,biological_process tube morphogenesis;GO:0042445,biological_process hormone metabolic process;GO:0042593,biological_process glucose homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048665,biological_process neuron fate specification;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051726,biological_process regulation of cell cycle;GO:0060425,biological_process lung morphogenesis;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060487,biological_process lung epithelial cell differentiation;GO:0060528,biological_process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060738,biological_process epithelial-mesenchymal signaling involved in prostate gland development;GO:0060740,biological_process prostate gland epithelium morphogenesis;GO:0060741,biological_process prostate gland stromal morphogenesis;GO:0060743,biological_process epithelial cell maturation involved in prostate gland development;GO:0061144,biological_process alveolar secondary septum development;GO:0061448,biological_process connective tissue development;GO:0071542,biological_process dopaminergic neuron differentiation;GO:1902691,biological_process respiratory basal cell differentiation;GO:2000049,biological_process positive regulation of cell-cell adhesion mediated by cadherin	NA	forkhead box A1 [Source:HGNC Symbol%3BAcc:HGNC:5021]
ENSG00000155189	15.34	12.82	15.36	15.03	17.25	18.75	-0.211550649238379	4.34677717124468	0.0450835697174828	0.284360950662152	8:6708356-6759666:+	AGPAT5	19;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006639,biological_process acylglycerol metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups	NA	1-acylglycerol-3-phosphate O-acyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:20886]
ENSG00000114423	9.12	8.40	10.74	7.52	8.67	8.62	0.204797810471712	4.75380648706341	0.0452255364066897	0.285111520272341	3:105655460-105869552:-	CBLB	25;GO:0001784,molecular_function phosphotyrosine binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0017124,molecular_function SH3 domain binding;GO:0023051,biological_process regulation of signaling;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0045121,cellular_component membrane raft;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]; K04707	Cbl proto-oncogene B [Source:HGNC Symbol%3BAcc:HGNC:1542]
ENSG00000242247	41.51	47.39	43.12	39.32	41.82	39.27	0.141379823860147	6.04478671345186	0.0452565415423196	0.285162157444067	22:42796501-42858106:-	ARFGAP3	17;GO:0000139,cellular_component Golgi membrane;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0008565,molecular_function protein transporter activity;GO:0009306,biological_process protein secretion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3; K12493	ADP ribosylation factor GTPase activating protein 3 [Source:HGNC Symbol%3BAcc:HGNC:661]
ENSG00000163933	14.58	15.66	13.97	17.44	16.40	16.20	-0.171732270682213	4.68085628550698	0.0452823701057271	0.285180142121964	3:53088482-53130462:-	RFT1	8;GO:0005319,molecular_function lipid transporter activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008643,biological_process carbohydrate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034203,biological_process glycolipid translocation	NA	RFT1 homolog [Source:HGNC Symbol%3BAcc:HGNC:30220]
ENSG00000163235	51.18	54.32	53.99	63.83	56.58	59.08	-0.160647417960812	4.9994335219976	0.04533262712928	0.285219914739566	2:70447279-70554193:-	TGFA	37;GO:0000139,cellular_component Golgi membrane;GO:0000187,biological_process activation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0008083,molecular_function growth factor activity;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042060,biological_process wound healing;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045741,biological_process positive regulation of epidermal growth factor-activated receptor activity;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048523,biological_process negative regulation of cellular process;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051781,biological_process positive regulation of cell division;GO:0060749,biological_process mammary gland alveolus development;GO:0072574,biological_process hepatocyte proliferation	TGFA; transforming growth factor, alpha; K08774	transforming growth factor alpha [Source:HGNC Symbol%3BAcc:HGNC:11765]
ENSG00000131459	8.72	7.79	7.93	7.23	7.12	7.44	0.181351612853474	4.33629578213614	0.0453395037009847	0.285219914739566	5:180300689-180353387:-	GFPT2	15;GO:0004360,molecular_function glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006002,biological_process fructose 6-phosphate metabolic process;GO:0006047,biological_process UDP-N-acetylglucosamine metabolic process;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0006112,biological_process energy reserve metabolic process;GO:0006487,biological_process protein N-linked glycosylation;GO:0006541,biological_process glutamine metabolic process;GO:0008483,molecular_function transaminase activity;GO:0016740,molecular_function transferase activity;GO:0097367,molecular_function carbohydrate derivative binding;GO:1901135,biological_process carbohydrate derivative metabolic process;GO:1901137,biological_process carbohydrate derivative biosynthetic process;GO:1990830,biological_process cellular response to leukemia inhibitory factor	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]; K00820	glutamine-fructose-6-phosphate transaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:4242]
ENSG00000264364	105.01	114.54	101.72	124.23	119.02	117.99	-0.162433014904609	4.93178047170949	0.0453576179566506	0.285219914739566	17:58083414-58095536:+	DYNLL2	34;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007017,biological_process microtubule-based process;GO:0007062,biological_process sister chromatid cohesion;GO:0008039,biological_process synaptic target recognition;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0010970,biological_process establishment of localization by movement along microtubule;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0016459,cellular_component myosin complex;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030286,cellular_component dynein complex;GO:0031475,cellular_component myosin V complex;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:2000582,biological_process positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	DYNLL; dynein light chain LC8-type; K10418	dynein light chain LC8-type 2 [Source:HGNC Symbol%3BAcc:HGNC:24596]
ENSG00000111371	83.58	78.21	81.15	85.12	91.93	90.61	-0.126985640629294	7.09936538379185	0.0454476825611284	0.285641561332297	12:46183062-46270017:-	SLC38A1	24;GO:0001504,biological_process neurotransmitter uptake;GO:0003333,biological_process amino acid transmembrane transport;GO:0005283,molecular_function sodium:amino acid symporter activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006865,biological_process amino acid transport;GO:0006868,biological_process glutamine transport;GO:0007565,biological_process female pregnancy;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015179,molecular_function L-amino acid transmembrane transporter activity;GO:0015186,molecular_function L-glutamine transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015804,biological_process neutral amino acid transport;GO:0015807,biological_process L-amino acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030424,cellular_component axon;GO:0070062,cellular_component extracellular exosome;GO:1902475,biological_process L-alpha-amino acid transmembrane transport	SLC38A1, SNAT1, GLNT; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 1; K14990	solute carrier family 38 member 1 [Source:HGNC Symbol%3BAcc:HGNC:13447]
ENSG00000174151	6.13	7.75	6.48	5.48	5.81	4.98	0.323123630514185	2.44488479434239	0.045490264424532	0.285686263987324	1:109494051-109502932:+	CYB561D1	4;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome b561 family member D1 [Source:HGNC Symbol%3BAcc:HGNC:26804]
ENSG00000185246	29.00	29.17	31.42	25.14	27.82	28.81	0.143989233965642	5.86270229656751	0.0455031116087777	0.285686263987324	14:45084098-45116282:+	PRPF39	9;GO:0000243,cellular_component commitment complex;GO:0000395,biological_process mRNA 5'-splice site recognition;GO:0005634,cellular_component nucleus;GO:0005685,cellular_component U1 snRNP;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030627,molecular_function pre-mRNA 5'-splice site binding;GO:0071004,cellular_component U2-type prespliceosome	NA	pre-mRNA processing factor 39 [Source:HGNC Symbol%3BAcc:HGNC:20314]
ENSG00000159200	13.01	8.98	14.10	18.21	11.88	15.62	-0.321454615034501	4.25059740088694	0.0455238403421355	0.285686263987324	21:34513141-34615142:-	RCAN1	19;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007417,biological_process central nervous system development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008015,biological_process blood circulation;GO:0008597,molecular_function calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0009612,biological_process response to mechanical stimulus;GO:0019722,biological_process calcium-mediated signaling;GO:0033173,biological_process calcineurin-NFAT signaling cascade;GO:0043627,biological_process response to estrogen;GO:0050790,biological_process regulation of catalytic activity;GO:0051151,biological_process negative regulation of smooth muscle cell differentiation;GO:0070884,biological_process regulation of calcineurin-NFAT signaling cascade	NA	regulator of calcineurin 1 [Source:HGNC Symbol%3BAcc:HGNC:3040]
ENSG00000056097	48.99	40.55	52.88	56.93	49.50	56.37	-0.179777425402454	7.36036251173838	0.0455537215675635	0.285729330883358	5:32354349-32444761:-	ZFR	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding	NA	zinc finger RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:17277]
ENSG00000160991	17.42	18.44	17.19	13.85	15.83	16.15	0.217728923905791	3.66480057197955	0.0456942067934479	0.286465751983368	7:102433105-102456821:+	ORAI2	7;GO:0002115,biological_process store-operated calcium entry;GO:0005515,molecular_function protein binding;GO:0015279,molecular_function store-operated calcium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030426,cellular_component growth cone;GO:0070588,biological_process calcium ion transmembrane transport	ORAI2; calcium release-activated calcium channel protein 2; K16057	ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol%3BAcc:HGNC:21667]
ENSG00000089820	0.57	0.62	0.50	0.48	0.29	0.32	0.622834826747585	0.652321353455318	0.0457516336504186	0.286680915715282	X:153907366-153934999:-	ARHGAP4	19;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007399,biological_process nervous system development;GO:0009967,biological_process positive regulation of signal transduction;GO:0010764,biological_process negative regulation of fibroblast migration;GO:0030336,biological_process negative regulation of cell migration;GO:0030426,cellular_component growth cone;GO:0030517,biological_process negative regulation of axon extension;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048365,molecular_function Rac GTPase binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 4 [Source:HGNC Symbol%3BAcc:HGNC:674]
ENSG00000196365	74.55	60.58	75.94	84.39	72.06	84.47	-0.17808267518967	7.83582833898908	0.045787117607791	0.286680915715282	19:5691833-5720572:-	LONP1	42;GO:0000002,biological_process mitochondrial genome maintenance;GO:0000166,molecular_function nucleotide binding;GO:0001666,biological_process response to hypoxia;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004176,molecular_function ATP-dependent peptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0007005,biological_process mitochondrion organization;GO:0007568,biological_process aging;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009725,biological_process response to hormone;GO:0010044,biological_process response to aluminum ion;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030163,biological_process protein catabolic process;GO:0032042,biological_process mitochondrial DNA metabolic process;GO:0034599,biological_process cellular response to oxidative stress;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043531,molecular_function ADP binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043623,biological_process cellular protein complex assembly;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051260,biological_process protein homooligomerization;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0051880,molecular_function G-quadruplex DNA binding;GO:0070182,molecular_function DNA polymerase binding;GO:0070361,molecular_function mitochondrial light strand promoter anti-sense binding;GO:0070362,molecular_function mitochondrial heavy strand promoter anti-sense binding;GO:0070407,biological_process oxidation-dependent protein catabolic process;GO:0090296,biological_process regulation of mitochondrial DNA replication	NA	lon peptidase 1%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:9479]
ENSG00000178826	0.98	2.06	0.80	1.96	3.28	1.41	-0.824791688642896	0.342088870413509	0.0457978132492874	0.286680915715282	7:143279956-143288048:+	TMEM139	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 139 [Source:HGNC Symbol%3BAcc:HGNC:22058]
ENSG00000159346	68.55	71.78	72.95	66.69	67.01	62.69	0.130509423630632	6.26630073971546	0.0458676562896254	0.286881878948454	1:202940822-202958572:-	ADIPOR1	29;GO:0004872,molecular_function receptor activity;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019395,biological_process fatty acid oxidation;GO:0019901,molecular_function protein kinase binding;GO:0030308,biological_process negative regulation of cell growth;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0033210,biological_process leptin-mediated signaling pathway;GO:0033211,biological_process adiponectin-activated signaling pathway;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0055100,molecular_function adiponectin binding;GO:0097003,molecular_function adipokinetic hormone receptor activity;GO:1901223,biological_process negative regulation of NIK/NF-kappaB signaling	ADIPOR; adiponectin receptor; K07297	adiponectin receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:24040]
ENSG00000183763	6.85	7.55	7.75	9.50	7.67	9.26	-0.246607405363336	3.56811806208868	0.0458761403135971	0.286881878948454	3:49828598-49856574:-	TRAIP	16;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	TRAF interacting protein [Source:HGNC Symbol%3BAcc:HGNC:30764]
ENSG00000083535	7.20	7.14	7.18	6.27	6.22	6.56	0.186709768765302	3.98236231503413	0.0460211009384319	0.287643467245093	13:72782058-73016461:+	PIBF1	25;GO:0002376,biological_process immune system process;GO:0005136,molecular_function interleukin-4 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007080,biological_process mitotic metaphase plate congression;GO:0031393,biological_process negative regulation of prostaglandin biosynthetic process;GO:0032695,biological_process negative regulation of interleukin-12 production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032815,biological_process negative regulation of natural killer cell activation;GO:0034451,cellular_component centriolar satellite;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0042802,molecular_function identical protein binding;GO:0042976,biological_process activation of Janus kinase activity;GO:0071539,biological_process protein localization to centrosome;GO:0090307,biological_process mitotic spindle assembly;GO:1905515,biological_process non-motile cilium assembly	NA	progesterone immunomodulatory binding factor 1 [Source:HGNC Symbol%3BAcc:HGNC:23352]
ENSG00000131018	3.27	2.86	3.05	2.74	2.89	2.81	0.137571961447539	6.35489402030476	0.046086578216082	0.287878757674221	6:152121683-152637801:-	SYNE1	30;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005640,cellular_component nuclear outer membrane;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0006997,biological_process nucleus organization;GO:0007030,biological_process Golgi organization;GO:0007283,biological_process spermatogenesis;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0030017,cellular_component sarcomere;GO:0030154,biological_process cell differentiation;GO:0031965,cellular_component nuclear membrane;GO:0034993,cellular_component LINC complex;GO:0042692,biological_process muscle cell differentiation;GO:0042803,molecular_function protein homodimerization activity;GO:0045211,cellular_component postsynaptic membrane;GO:0051015,molecular_function actin filament binding;GO:0090286,biological_process cytoskeletal anchoring at nuclear membrane;GO:0090292,biological_process nuclear matrix anchoring at nuclear membrane	NA	spectrin repeat containing nuclear envelope protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17089]
ENSG00000140525	17.64	18.25	15.65	19.36	18.97	18.95	-0.142585058187547	6.18826101698229	0.0461051293205793	0.287878757674221	15:89243948-89317261:+	FANCI	13;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0016020,cellular_component membrane;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0036297,biological_process interstrand cross-link repair;GO:0070182,molecular_function DNA polymerase binding	FANCI; fanconi anemia group I protein; K10895	Fanconi anemia complementation group I [Source:HGNC Symbol%3BAcc:HGNC:25568]
ENSG00000118855	19.78	19.60	19.49	16.90	18.60	18.17	0.145104951334071	5.15546448636168	0.0461745821096838	0.287922520427545	3:158732197-158829719:+	MFSD1	4;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	major facilitator superfamily domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25874]
ENSG00000180611	2.49	3.24	2.80	3.05	4.38	3.72	-0.386037545058777	2.3159941307694	0.0462018726888031	0.287922520427545	3:192796814-192918161:-	MB21D2	2;GO:0032403,molecular_function protein complex binding;GO:0045296,molecular_function cadherin binding	NA	Mab-21 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30438]
ENSG00000149403	0.99	0.77	0.87	0.37	0.74	0.71	0.548889134268768	1.18884908768428	0.0462101616822672	0.287922520427545	11:120511699-120988904:+	GRIK4	24;GO:0004872,molecular_function receptor activity;GO:0004970,molecular_function ionotropic glutamate receptor activity;GO:0005216,molecular_function ion channel activity;GO:0005234,molecular_function extracellular-glutamate-gated ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007215,biological_process glutamate receptor signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015277,molecular_function kainate selective glutamate receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0032983,cellular_component kainate selective glutamate receptor complex;GO:0034220,biological_process ion transmembrane transport;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042734,cellular_component presynaptic membrane;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0060079,biological_process excitatory postsynaptic potential;GO:0071805,biological_process potassium ion transmembrane transport	GRIK4; glutamate receptor, ionotropic kainate 4; K05204	glutamate ionotropic receptor kainate type subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:4582]
ENSG00000110768	37.21	37.33	39.08	40.95	41.79	42.25	-0.125371686821642	6.12229457021512	0.0462181993506066	0.287922520427545	11:18322294-18367044:+	GTF2H1	33;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000439,cellular_component core TFIIH complex;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003682,molecular_function chromatin binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005675,cellular_component holo TFIIH complex;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006360,biological_process transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070816,biological_process phosphorylation of RNA polymerase II C-terminal domain;GO:0070911,biological_process global genome nucleotide-excision repair	TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1; K03141	general transcription factor IIH subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4655]
ENSG00000186222	14.65	13.07	12.32	15.87	13.86	19.87	-0.298025464552044	3.31249408517456	0.0462281143327236	0.287922520427545	4:6716054-6717671:+	BLOC1S4	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008089,biological_process anterograde axonal transport;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0032438,biological_process melanosome organization;GO:0046907,biological_process intracellular transport;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0050885,biological_process neuromuscular process controlling balance;GO:0070527,biological_process platelet aggregation;GO:1904115,cellular_component axon cytoplasm	NA	biogenesis of lysosomal organelles complex 1 subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:24206]
ENSG00000179163	37.23	37.67	38.12	34.97	34.45	34.76	0.128959792260326	5.66580351808194	0.0463740740086622	0.288554427376177	1:23845076-23868294:-	FUCA1	16;GO:0004560,molecular_function alpha-L-fucosidase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0006004,biological_process fucose metabolic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008152,biological_process metabolic process;GO:0016139,biological_process glycoside catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019377,biological_process glycolipid catabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	FUCA; alpha-L-fucosidase [EC:3.2.1.51]; K01206	fucosidase%2C alpha-L- 1%2C tissue [Source:HGNC Symbol%3BAcc:HGNC:4006]
ENSG00000050405	22.99	22.61	22.55	18.69	22.65	20.45	0.153807334625505	5.6452874386513	0.0463760640147808	0.288554427376177	12:50175787-50283546:-	LIMA1	17;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005903,cellular_component brush border;GO:0005925,cellular_component focal adhesion;GO:0015629,cellular_component actin cytoskeleton;GO:0030054,cellular_component cell junction;GO:0030835,biological_process negative regulation of actin filament depolymerization;GO:0031529,biological_process ruffle organization;GO:0032154,cellular_component cleavage furrow;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly	NA	LIM domain and actin binding 1 [Source:HGNC Symbol%3BAcc:HGNC:24636]
ENSG00000037241	72.74	73.38	66.66	80.90	74.97	83.09	-0.158595653867993	5.04156098088325	0.0464148992945953	0.28865137522235	5:172958728-172969771:+	RPL26L1	11;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015934,cellular_component large ribosomal subunit;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0070062,cellular_component extracellular exosome	RP-L26e, RPL26; large subunit ribosomal protein L26e; K02898	ribosomal protein L26 like 1 [Source:HGNC Symbol%3BAcc:HGNC:17050]
ENSG00000101473	18.40	20.63	18.23	15.21	16.58	18.38	0.194950154089995	4.30471491060117	0.0464609833486587	0.288793283078067	20:45841720-45857406:-	ACOT8	24;GO:0003986,molecular_function acetyl-CoA hydrolase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006637,biological_process acyl-CoA metabolic process;GO:0006699,biological_process bile acid biosynthetic process;GO:0007031,biological_process peroxisome organization;GO:0009062,biological_process fatty acid catabolic process;GO:0016032,biological_process viral process;GO:0016289,molecular_function CoA hydrolase activity;GO:0016290,molecular_function palmitoyl-CoA hydrolase activity;GO:0016559,biological_process peroxisome fission;GO:0016787,molecular_function hydrolase activity;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0033882,molecular_function choloyl-CoA hydrolase activity;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0043649,biological_process dicarboxylic acid catabolic process;GO:0045225,biological_process negative regulation of CD4 biosynthetic process;GO:0047617,molecular_function acyl-CoA hydrolase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0052815,molecular_function medium-chain acyl-CoA hydrolase activity	ACOT8, PTE; acyl-CoA thioesterase 8 [EC:3.1.2.27]; K11992	acyl-CoA thioesterase 8 [Source:HGNC Symbol%3BAcc:HGNC:15919]
ENSG00000244486	0.84	0.51	0.96	0.69	0.46	0.38	0.635715111421347	0.876656025139671	0.0465161600283551	0.288991538754741	22:20424814-20437826:-	SCARF2	8;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0005925,cellular_component focal adhesion;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	scavenger receptor class F member 2 [Source:HGNC Symbol%3BAcc:HGNC:19869]
ENSG00000160323	1.54	1.43	1.69	1.80	1.82	2.05	-0.268453505448296	2.98732458939139	0.0465983607463729	0.289357404674701	9:133414357-133459402:+	ADAMTS13	35;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006508,biological_process proteolysis;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009100,biological_process glycoprotein metabolic process;GO:0009636,biological_process response to toxic substance;GO:0009986,cellular_component cell surface;GO:0014075,biological_process response to amine;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0030168,biological_process platelet activation;GO:0034341,biological_process response to interferon-gamma;GO:0034612,biological_process response to tumor necrosis factor;GO:0035864,biological_process response to potassium ion;GO:0036066,biological_process protein O-linked fucosylation;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070670,biological_process response to interleukin-4;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071353,biological_process cellular response to interleukin-4;GO:0071356,biological_process cellular response to tumor necrosis factor	NA	ADAM metallopeptidase with thrombospondin type 1 motif 13 [Source:HGNC Symbol%3BAcc:HGNC:1366]
ENSG00000170667	0.50	0.48	0.67	0.22	0.28	0.50	0.726441501875362	0.282054723387825	0.0466469817930869	0.289372303328307	7:102482444-102517781:-	RASA4B	13;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0035556,biological_process intracellular signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding	NA	RAS p21 protein activator 4B [Source:HGNC Symbol%3BAcc:HGNC:35202]
ENSG00000198937	39.80	55.83	40.22	51.20	62.29	51.71	-0.282809322964425	3.87696918811133	0.0466473841102024	0.289372303328307	6:37482919-37499922:-	CCDC167	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	coiled-coil domain containing 167 [Source:HGNC Symbol%3BAcc:HGNC:21239]
ENSG00000246705	96.91	95.81	102.32	108.54	101.52	122.65	-0.161539363623122	5.34778109142489	0.0466930309170281	0.289510785600934	12:14774382-14778002:+	H2AFJ	10;GO:0000786,cellular_component nucleosome;GO:0000790,cellular_component nuclear chromatin;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006342,biological_process chromatin silencing;GO:0008150,biological_process biological_process;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome	H2A; histone H2A; K11251	H2A histone family member J [Source:HGNC Symbol%3BAcc:HGNC:14456]
ENSG00000102098	2.99	3.77	3.88	3.88	4.69	4.51	-0.292941038895416	3.08305070473096	0.0468091717722106	0.290044184763524	X:18239313-18354727:-	SCML2	7;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009653,biological_process anatomical structure morphogenesis;GO:0031519,cellular_component PcG protein complex	NA	sex comb on midleg like 2 (Drosophila) [Source:HGNC Symbol%3BAcc:HGNC:10581]
ENSG00000117616	104.73	95.97	106.08	89.35	96.50	95.86	0.136643072286807	6.52438108918721	0.0468257912080965	0.290044184763524	1:25242236-25338213:-	RSRP1	1;GO:0005515,molecular_function protein binding	NA	arginine and serine rich protein 1 [Source:HGNC Symbol%3BAcc:HGNC:25234]
ENSG00000078725	45.03	59.09	42.18	38.32	49.51	35.84	0.252740357217134	6.70568357572698	0.0469218317168391	0.290494113267393	9:119153457-119369467:-	BRINP1	19;GO:0001662,biological_process behavioral fear response;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007614,biological_process short-term memory;GO:0008219,biological_process cell death;GO:0030425,cellular_component dendrite;GO:0035176,biological_process social behavior;GO:0035640,biological_process exploration behavior;GO:0042711,biological_process maternal behavior;GO:0043025,cellular_component neuronal cell body;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0050768,biological_process negative regulation of neurogenesis;GO:0071300,biological_process cellular response to retinoic acid;GO:0071625,biological_process vocalization behavior	NA	BMP/retinoic acid inducible neural specific 1 [Source:HGNC Symbol%3BAcc:HGNC:2687]
ENSG00000205189	6.52	6.91	6.41	7.24	7.73	7.63	-0.180248297981993	4.27259036514655	0.0470067925547418	0.290875032892328	8:80485618-80526265:+	ZBTB10	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:30953]
ENSG00000074660	0.56	0.38	0.52	0.21	0.27	0.42	0.725357593760585	0.204596425567563	0.0471154782366217	0.291269810765849	17:1633857-1645747:-	SCARF1	15;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005886,cellular_component plasma membrane;GO:0006707,biological_process cholesterol catabolic process;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016322,biological_process neuron remodeling;GO:0016358,biological_process dendrite development;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030666,cellular_component endocytic vesicle membrane;GO:0048680,biological_process positive regulation of axon regeneration	NA	scavenger receptor class F member 1 [Source:HGNC Symbol%3BAcc:HGNC:16820]
ENSG00000131653	33.10	35.51	33.21	30.98	31.49	31.35	0.127190569882911	6.07185160985387	0.0471207770073337	0.291269810765849	16:2155697-2178129:+	TRAF7	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000185,biological_process activation of MAPKKK activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0046872,molecular_function metal ion binding;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	TNF receptor associated factor 7 [Source:HGNC Symbol%3BAcc:HGNC:20456]
ENSG00000228716	28.58	34.92	33.46	36.84	42.99	34.09	-0.225074071943221	4.31106360141005	0.0471409852435826	0.291269810765849	5:80626227-80654983:-	DHFR	32;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004146,molecular_function dihydrofolate reductase activity;GO:0005515,molecular_function protein binding;GO:0005542,molecular_function folic acid binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006545,biological_process glycine biosynthetic process;GO:0006729,biological_process tetrahydrobiopterin biosynthetic process;GO:0006730,biological_process one-carbon metabolic process;GO:0008144,molecular_function drug binding;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0017148,biological_process negative regulation of translation;GO:0031103,biological_process axon regeneration;GO:0031427,biological_process response to methotrexate;GO:0033560,molecular_function folate reductase activity;GO:0046452,biological_process dihydrofolate metabolic process;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046654,biological_process tetrahydrofolate biosynthetic process;GO:0046655,biological_process folic acid metabolic process;GO:0050661,molecular_function NADP binding;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051870,molecular_function methotrexate binding;GO:0055114,biological_process oxidation-reduction process;GO:0070402,molecular_function NADPH binding;GO:1990825,molecular_function sequence-specific mRNA binding;GO:2000121,biological_process regulation of removal of superoxide radicals	DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]; K00287	dihydrofolate reductase [Source:HGNC Symbol%3BAcc:HGNC:2861]
ENSG00000137413	8.39	9.27	8.21	11.13	8.94	11.03	-0.26199469033381	3.4109565897797	0.04718045762555	0.291292883397764	6:42050512-42087461:+	TAF8	16;GO:0001833,biological_process inner cell mass cell proliferation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051457,biological_process maintenance of protein location in nucleus	TAF8; transcription initiation factor TFIID subunit 8; K14649	TATA-box binding protein associated factor 8 [Source:HGNC Symbol%3BAcc:HGNC:17300]
ENSG00000121653	6.63	6.81	6.58	5.74	5.75	6.06	0.198520723241747	3.80060016692838	0.0471916529858136	0.291292883397764	11:45885650-45906465:+	MAPK8IP1	35;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005078,molecular_function MAP-kinase scaffold activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007258,biological_process JUN phosphorylation;GO:0008432,molecular_function JUN kinase binding;GO:0009967,biological_process positive regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019894,molecular_function kinesin binding;GO:0019901,molecular_function protein kinase binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0043005,cellular_component neuron projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043508,biological_process negative regulation of JUN kinase activity;GO:0044294,cellular_component dendritic growth cone;GO:0044295,cellular_component axonal growth cone;GO:0044297,cellular_component cell body;GO:0044302,cellular_component dentate gyrus mossy fiber;GO:0045202,cellular_component synapse;GO:0046328,biological_process regulation of JNK cascade;GO:0046329,biological_process negative regulation of JNK cascade;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	MAPK8IP1, JIP1; mitogen-activated protein kinase 8 interacting protein 1; K04434	mitogen-activated protein kinase 8 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6882]
ENSG00000143622	37.58	37.91	39.06	35.55	36.23	30.35	0.17925412963404	4.69979737687661	0.0473017711125965	0.291745753201626	1:155897807-155911404:-	RIT1	10;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0016020,cellular_component membrane	NA	Ras like without CAAX 1 [Source:HGNC Symbol%3BAcc:HGNC:10023]
ENSG00000170854	20.54	18.51	19.78	22.86	20.96	22.44	-0.155665487415948	4.92988749596897	0.0473235975806087	0.291745753201626	3:97941817-97972457:-	RIOX2	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001191,molecular_function transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016491,molecular_function oxidoreductase activity;GO:0016577,biological_process histone demethylation;GO:0030961,biological_process peptidyl-arginine hydroxylation;GO:0032452,molecular_function histone demethylase activity;GO:0032453,molecular_function histone demethylase activity (H3-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0042254,biological_process ribosome biogenesis;GO:0042802,molecular_function identical protein binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation	NA	ribosomal oxygenase 2 [Source:HGNC Symbol%3BAcc:HGNC:19441]
ENSG00000100557	64.38	63.77	61.85	69.20	72.08	67.85	-0.126561644250755	6.20913392063615	0.0473480731807679	0.291745753201626	14:57469300-57493867:-	C14orf105	NA	NA	chromosome 14 open reading frame 105 [Source:HGNC Symbol%3BAcc:HGNC:20189]
ENSG00000120709	17.43	16.40	16.60	17.92	20.88	18.84	-0.178691221490691	4.47525368484528	0.0473590342947939	0.291745753201626	5:138331934-138349729:+	FAM53C	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 53 member C [Source:HGNC Symbol%3BAcc:HGNC:1336]
ENSG00000068650	4.65	4.75	5.25	5.18	5.89	5.78	-0.189660816964187	4.3266214408215	0.0474546588122958	0.292113013832468	13:112690328-112887168:+	ATP11A	23;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0035579,cellular_component specific granule membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding;GO:0055037,cellular_component recycling endosome;GO:0070821,cellular_component tertiary granule membrane	NA	ATPase phospholipid transporting 11A [Source:HGNC Symbol%3BAcc:HGNC:13552]
ENSG00000006652	108.59	83.04	114.66	89.77	83.18	96.24	0.199655901706078	7.10097561531939	0.0474657173044459	0.292113013832468	7:112422967-112481017:+	IFRD1	10;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007518,biological_process myoblast fate determination;GO:0014706,biological_process striated muscle tissue development;GO:0030154,biological_process cell differentiation;GO:0030517,biological_process negative regulation of axon extension;GO:0042692,biological_process muscle cell differentiation;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0048671,biological_process negative regulation of collateral sprouting	NA	interferon related developmental regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:5456]
ENSG00000205758	23.44	23.82	24.43	21.44	20.66	23.00	0.149754636497032	5.03187120249511	0.0474995455377491	0.292176342299345	21:33589340-33643926:-	CRYZL1	6;GO:0003960,molecular_function NADPH:quinone reductase activity;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process;GO:1901661,biological_process quinone metabolic process	NA	crystallin zeta like 1 [Source:HGNC Symbol%3BAcc:HGNC:2420]
ENSG00000176973	24.48	25.67	26.02	23.23	21.82	21.57	0.203876599892806	3.79308880418951	0.0476096166265786	0.292577439228791	11:65572348-65574198:+	FAM89B	5;GO:0001222,molecular_function transcription corepressor binding;GO:0005737,cellular_component cytoplasm;GO:0009986,cellular_component cell surface;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392,biological_process negative regulation of SMAD protein import into nucleus	NA	family with sequence similarity 89 member B [Source:HGNC Symbol%3BAcc:HGNC:16708]
ENSG00000119638	30.74	29.30	31.51	27.49	27.93	29.13	0.127786660625865	6.44081231469636	0.0476293881260796	0.292577439228791	14:75079352-75127344:-	NEK9	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	NA	NIMA related kinase 9 [Source:HGNC Symbol%3BAcc:HGNC:18591]
ENSG00000163347	81.11	70.20	87.44	91.31	82.79	97.09	-0.168223664839912	5.75784607224999	0.0476580584011585	0.292577439228791	3:190305700-190322475:-	CLDN1	39;GO:0001618,molecular_function virus receptor activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007568,biological_process aging;GO:0008065,biological_process establishment of blood-nerve barrier;GO:0009636,biological_process response to toxic substance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016338,biological_process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030054,cellular_component cell junction;GO:0032496,biological_process response to lipopolysaccharide;GO:0042538,biological_process hyperosmotic salinity response;GO:0042802,molecular_function identical protein binding;GO:0045216,biological_process cell-cell junction organization;GO:0045471,biological_process response to ethanol;GO:0046718,biological_process viral entry into host cell;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization;GO:0061436,biological_process establishment of skin barrier;GO:0061772,biological_process drug transport across blood-nerve barrier;GO:0070673,biological_process response to interleukin-18;GO:0070830,biological_process bicellular tight junction assembly;GO:0071284,biological_process cellular response to lead ion;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071548,biological_process response to dexamethasone;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:0097421,biological_process liver regeneration;GO:1903348,biological_process positive regulation of bicellular tight junction assembly;GO:1903545,biological_process cellular response to butyrate	CLDN; claudin; K06087	claudin 1 [Source:HGNC Symbol%3BAcc:HGNC:2032]
ENSG00000243509	3.30	2.65	3.43	2.99	1.60	2.11	0.507962123832668	1.3624349450929	0.0476590334424083	0.292577439228791	20:63696667-63698684:+	TNFRSF6B	16;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007275,biological_process multicellular organism development;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0097190,biological_process apoptotic signaling pathway	TNFRSF6B, DCR3; tumor necrosis factor receptor superfamily member 6B; K05143	TNF receptor superfamily member 6b [Source:HGNC Symbol%3BAcc:HGNC:11921]
ENSG00000023608	77.60	77.91	79.60	90.67	81.96	87.01	-0.131425885567446	6.51208303664036	0.047757473356401	0.293036834786458	14:61762356-61796428:+	SNAPC1	9;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0019185,cellular_component snRNA-activating protein complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042796,biological_process snRNA transcription from RNA polymerase III promoter;GO:0043565,molecular_function sequence-specific DNA binding	NA	small nuclear RNA activating complex polypeptide 1 [Source:HGNC Symbol%3BAcc:HGNC:11134]
ENSG00000183496	3.41	3.67	4.01	2.72	3.62	2.59	0.326182631860696	2.71301961346743	0.0478250018013364	0.293306199288532	15:82041777-82046141:-	MEX3B	11;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding	NA	mex-3 RNA binding family member B [Source:HGNC Symbol%3BAcc:HGNC:25297]
ENSG00000164902	35.19	33.23	33.31	35.47	38.11	39.74	-0.142926634648072	5.41246642432525	0.0479124548461513	0.293610573844712	5:126600267-126627252:+	PHAX	15;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006408,biological_process snRNA export from nucleus;GO:0006810,biological_process transport;GO:0015030,cellular_component Cajal body;GO:0015031,biological_process protein transport;GO:0015643,molecular_function toxic substance binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043025,cellular_component neuronal cell body;GO:0051168,biological_process nuclear export	PHAX; phosphorylated adapter RNA export protein; K14291	phosphorylated adaptor for RNA export [Source:HGNC Symbol%3BAcc:HGNC:10241]
ENSG00000137871	6.16	6.28	6.11	5.53	5.26	5.75	0.174352765667675	4.27599849631058	0.0479219385007158	0.293610573844712	15:56630180-56918571:-	ZNF280D	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 280D [Source:HGNC Symbol%3BAcc:HGNC:25953]
ENSG00000129810	9.06	8.54	7.84	9.73	10.04	9.64	-0.196820542867498	3.97458182719742	0.0480619371708834	0.294323051851098	3:20160592-20186292:-	SGO1	22;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0010457,biological_process centriole-centriole cohesion;GO:0019900,molecular_function kinase binding;GO:0045132,biological_process meiotic chromosome segregation;GO:0051301,biological_process cell division	SGOL1; shugoshin-like 1; K11580	shugoshin 1 [Source:HGNC Symbol%3BAcc:HGNC:25088]
ENSG00000100485	16.84	15.35	16.62	14.16	16.29	13.94	0.151366486982897	6.01155996797477	0.0482722620675165	0.295465280593729	14:50117119-50231558:-	SOS2	12;GO:0003677,molecular_function DNA binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051057,biological_process positive regulation of small GTPase mediated signal transduction	SOS; son of sevenless; K03099	SOS Ras/Rho guanine nucleotide exchange factor 2 [Source:HGNC Symbol%3BAcc:HGNC:11188]
ENSG00000103342	95.61	96.80	100.51	105.60	104.51	110.84	-0.120011806280039	7.63649371347955	0.0483024796647701	0.295504524435087	16:11868127-11916082:-	GSPT1	15;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002184,biological_process cytoplasmic translational termination;GO:0003723,molecular_function RNA binding;GO:0003747,molecular_function translation release factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006415,biological_process translational termination;GO:0006479,biological_process protein methylation;GO:0018444,cellular_component translation release factor complex	ERF3, GSPT; peptide chain release factor subunit 3; K03267	G1 to S phase transition 1 [Source:HGNC Symbol%3BAcc:HGNC:4621]
ENSG00000137288	59.79	61.18	62.70	64.18	70.22	73.67	-0.169416220705507	4.63656311682652	0.0483296539490501	0.295525120428354	6:33694292-33711727:-	UQCC2	14;GO:0002082,biological_process regulation of oxidative phosphorylation;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly;GO:0042645,cellular_component mitochondrial nucleoid;GO:0050796,biological_process regulation of insulin secretion;GO:0070131,biological_process positive regulation of mitochondrial translation;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:2001014,biological_process regulation of skeletal muscle cell differentiation	NA	ubiquinol-cytochrome c reductase complex assembly factor 2 [Source:HGNC Symbol%3BAcc:HGNC:21237]
ENSG00000170004	60.32	59.64	59.82	55.68	55.77	56.43	0.110702752822234	8.55636326144233	0.0483669989495044	0.295550398226749	17:7884805-7912760:+	CHD3	30;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006325,biological_process chromatin organization;GO:0006333,biological_process chromatin assembly or disassembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007051,biological_process spindle organization;GO:0007098,biological_process centrosome cycle;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016581,cellular_component NuRD complex;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0046872,molecular_function metal ion binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	chromodomain helicase DNA binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:1918]
ENSG00000083937	41.63	42.68	48.08	35.72	41.13	41.35	0.176099968278953	4.92011482578917	0.0483814073307624	0.295550398226749	3:87227270-87255548:+	CHMP2B	34;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0006997,biological_process nucleus organization;GO:0007032,biological_process endosome organization;GO:0007034,biological_process vacuolar transport;GO:0007080,biological_process mitotic metaphase plate congression;GO:0010824,biological_process regulation of centrosome duplication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0019904,molecular_function protein domain specific binding;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0045296,molecular_function cadherin binding;GO:0050890,biological_process cognition;GO:0061763,biological_process multivesicular body-lysosome fusion;GO:0070050,biological_process neuron cellular homeostasis;GO:0070062,cellular_component extracellular exosome;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1902188,biological_process positive regulation of viral release from host cell;GO:1904903,biological_process ESCRT III complex disassembly	CHMP2B; charged multivesicular body protein 2B; K12192	charged multivesicular body protein 2B [Source:HGNC Symbol%3BAcc:HGNC:24537]
ENSG00000143674	19.09	19.77	19.15	21.90	20.38	21.61	-0.129108972626358	6.00711847168324	0.0484275507539046	0.295686762178169	1:233327767-233385148:+	MAP3K21	23;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004706,molecular_function JUN kinase kinase kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007256,biological_process activation of JNKK activity;GO:0007257,biological_process activation of JUN kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042803,molecular_function protein homodimerization activity;GO:0046777,biological_process protein autophosphorylation	NA	mitogen-activated protein kinase kinase kinase 21 [Source:HGNC Symbol%3BAcc:HGNC:29798]
ENSG00000135828	2.83	2.31	2.40	2.54	3.50	3.56	-0.330434244484944	2.74191460442889	0.0484976968009254	0.295929531332884	1:182573633-182589256:-	RNASEL	33;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0016363,cellular_component nuclear matrix;GO:0016787,molecular_function hydrolase activity;GO:0019843,molecular_function rRNA binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043488,biological_process regulation of mRNA stability;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045444,biological_process fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	RNASEL; ribonuclease L; K01165	ribonuclease L [Source:HGNC Symbol%3BAcc:HGNC:10050]
ENSG00000104765	99.74	97.00	94.79	91.37	92.78	83.81	0.134148069836691	5.9625693345081	0.0485149920456311	0.295929531332884	8:26382897-26505636:+	BNIP3L	31;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0010917,biological_process negative regulation of mitochondrial membrane potential;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016607,cellular_component nuclear speck;GO:0031224,cellular_component intrinsic component of membrane;GO:0035694,biological_process mitochondrial protein catabolic process;GO:0035794,biological_process positive regulation of mitochondrial membrane permeability;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0051607,biological_process defense response to virus;GO:0060548,biological_process negative regulation of cell death;GO:0071456,biological_process cellular response to hypoxia;GO:0097345,biological_process mitochondrial outer membrane permeabilization;GO:1903146,biological_process regulation of mitophagy;GO:1903214,biological_process regulation of protein targeting to mitochondrion	BNIP3L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; K15465	BCL2 interacting protein 3 like [Source:HGNC Symbol%3BAcc:HGNC:1085]
ENSG00000109323	28.29	30.10	30.31	26.87	28.53	26.18	0.131748428719762	6.24320764019138	0.0485472248727825	0.295980698598158	4:102631487-102760994:-	MANBA	15;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004567,molecular_function beta-mannosidase activity;GO:0005537,molecular_function mannose binding;GO:0005764,cellular_component lysosome;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0008152,biological_process metabolic process;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0035577,cellular_component azurophil granule membrane;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation	E3.2.1.25, MANBA, manB; beta-mannosidase [EC:3.2.1.25]; K01192	mannosidase beta [Source:HGNC Symbol%3BAcc:HGNC:6831]
ENSG00000128271	1.60	1.55	2.02	0.85	1.41	1.31	0.551062785181481	0.964166879661032	0.0486524077138556	0.296476355892042	22:24417878-24442360:+	ADORA2A	81;GO:0001609,molecular_function G-protein coupled adenosine receptor activity;GO:0001963,biological_process synaptic transmission, dopaminergic;GO:0001973,biological_process adenosine receptor signaling pathway;GO:0001975,biological_process response to amphetamine;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006171,biological_process cAMP biosynthetic process;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006909,biological_process phagocytosis;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006968,biological_process cellular defense response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0007417,biological_process central nervous system development;GO:0007596,biological_process blood coagulation;GO:0007600,biological_process sensory perception;GO:0007626,biological_process locomotory behavior;GO:0008015,biological_process blood circulation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010579,biological_process positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway;GO:0012505,cellular_component endomembrane system;GO:0014049,biological_process positive regulation of glutamate secretion;GO:0014057,biological_process positive regulation of acetylcholine secretion, neurotransmission;GO:0014061,biological_process regulation of norepinephrine secretion;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030673,cellular_component axolemma;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031000,biological_process response to caffeine;GO:0031802,molecular_function type 5 metabotropic glutamate receptor binding;GO:0032230,biological_process positive regulation of synaptic transmission, GABAergic;GO:0032279,cellular_component asymmetric synapse;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035810,biological_process positive regulation of urine volume;GO:0035815,biological_process positive regulation of renal sodium excretion;GO:0040013,biological_process negative regulation of locomotion;GO:0042311,biological_process vasodilation;GO:0042493,biological_process response to drug;GO:0042734,cellular_component presynaptic membrane;GO:0042755,biological_process eating behavior;GO:0042802,molecular_function identical protein binding;GO:0043025,cellular_component neuronal cell body;GO:0043116,biological_process negative regulation of vascular permeability;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043279,biological_process response to alkaloid;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044267,biological_process cellular protein metabolic process;GO:0045211,cellular_component postsynaptic membrane;GO:0045938,biological_process positive regulation of circadian sleep/wake cycle, sleep;GO:0046636,biological_process negative regulation of alpha-beta T cell activation;GO:0046982,molecular_function protein heterodimerization activity;GO:0048143,biological_process astrocyte activation;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048786,cellular_component presynaptic active zone;GO:0048812,biological_process neuron projection morphogenesis;GO:0050714,biological_process positive regulation of protein secretion;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051393,molecular_function alpha-actinin binding;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0051899,biological_process membrane depolarization;GO:0051924,biological_process regulation of calcium ion transport;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060080,biological_process inhibitory postsynaptic potential;GO:0060134,biological_process prepulse inhibition;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	ADORA2A, ADOR; adenosine receptor A2a; K04266	adenosine A2a receptor [Source:HGNC Symbol%3BAcc:HGNC:263]
ENSG00000253293	33.49	34.68	35.91	33.99	28.93	31.42	0.152922262500381	5.36312684362042	0.0487605788589491	0.296873574638387	7:27170590-27180261:-	HOXA10	23;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0008584,biological_process male gonad development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009954,biological_process proximal/distal pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0030326,biological_process embryonic limb morphogenesis;GO:0042826,molecular_function histone deacetylase binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060065,biological_process uterus development	HOXA10; homrobox protein Hox-A10; K17443	homeobox A10 [Source:HGNC Symbol%3BAcc:HGNC:5100]
ENSG00000178038	9.71	8.52	11.38	8.62	8.33	9.08	0.203890307047899	4.74052202484938	0.0487743771662329	0.296873574638387	3:46668996-46693704:-	ALS2CL	10;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007032,biological_process endosome organization;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042802,molecular_function identical protein binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	ALS2 C-terminal like [Source:HGNC Symbol%3BAcc:HGNC:20605]
ENSG00000160796	5.40	5.84	5.96	5.21	5.23	5.30	0.137657758156722	5.50808411194103	0.048789341195707	0.296873574638387	3:46979682-47009703:+	NBEAL2	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0030220,biological_process platelet formation;GO:0043312,biological_process neutrophil degranulation;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	neurobeachin like 2 [Source:HGNC Symbol%3BAcc:HGNC:31928]
ENSG00000165724	24.79	26.94	25.51	22.32	19.16	25.30	0.21559537004137	4.04202079891505	0.0488185781494572	0.296905933644886	9:137582078-137590490:-	ZMYND19	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding	NA	zinc finger MYND-type containing 19 [Source:HGNC Symbol%3BAcc:HGNC:21146]
ENSG00000061656	32.78	33.14	37.19	33.41	27.77	31.48	0.166589135784739	5.45400649766134	0.048849930857301	0.296910791201183	20:35615891-35621049:+	SPAG4	17;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006998,biological_process nuclear envelope organization;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0031514,cellular_component motile cilium;GO:0042995,cellular_component cell projection;GO:0043495,molecular_function protein anchor;GO:0090286,biological_process cytoskeletal anchoring at nuclear membrane	NA	sperm associated antigen 4 [Source:HGNC Symbol%3BAcc:HGNC:11214]
ENSG00000214940	9.72	8.57	11.41	8.15	8.79	8.15	0.265426558513743	3.41424703940042	0.0488711572195462	0.296910791201183	16:18317941-18336736:-	NPIPA8	1;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex interacting protein family member A8 [Source:HGNC Symbol%3BAcc:HGNC:41983]
ENSG00000109339	9.93	9.96	11.10	12.78	11.03	11.57	-0.177751801127118	4.65244069879516	0.0489139545983126	0.296910791201183	4:85990006-86594625:-	MAPK10	33;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004705,molecular_function JUN kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007254,biological_process JNK cascade;GO:0007258,biological_process JUN phosphorylation;GO:0009416,biological_process response to light stimulus;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042752,biological_process regulation of circadian rhythm;GO:0043005,cellular_component neuron projection;GO:0048511,biological_process rhythmic process;GO:0048666,biological_process neuron development;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity	JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]; K04440	mitogen-activated protein kinase 10 [Source:HGNC Symbol%3BAcc:HGNC:6872]
ENSG00000125991	229.87	225.49	225.89	215.22	210.74	209.13	0.113113380555957	8.20780430973172	0.0489150542178699	0.296910791201183	20:35542020-35557634:+	ERGIC3	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane	NA	ERGIC and golgi 3 [Source:HGNC Symbol%3BAcc:HGNC:15927]
ENSG00000125651	54.85	51.61	51.30	57.34	58.42	57.81	-0.125154464541567	6.60561382990711	0.0489716473200943	0.297090734789797	19:6379568-6393981:-	GTF2F1	31;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005674,cellular_component transcription factor TFIIF complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0008134,molecular_function transcription factor binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009615,biological_process response to virus;GO:0016070,biological_process RNA metabolic process;GO:0019211,molecular_function phosphatase activator activity;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050434,biological_process positive regulation of viral transcription	TFIIF1, GTF2F1, TFG1; transcription initiation factor TFIIF subunit alpha; K03138	general transcription factor IIF subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4652]
ENSG00000198393	5.78	5.91	4.98	6.79	7.10	6.05	-0.248861805658452	3.39447357772535	0.0489925669954656	0.297090734789797	12:132986364-133032952:+	ZNF26	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 26 [Source:HGNC Symbol%3BAcc:HGNC:13053]
ENSG00000105245	15.15	12.76	14.87	12.58	11.96	13.59	0.183952879948506	4.63517081991618	0.0491483674290071	0.297889982859505	19:40665904-40690972:-	NUMBL	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007405,biological_process neuroblast proliferation;GO:0007409,biological_process axonogenesis;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019538,biological_process protein metabolic process;GO:0021670,biological_process lateral ventricle development;GO:0021849,biological_process neuroblast division in subventricular zone;GO:0030900,biological_process forebrain development;GO:0034332,biological_process adherens junction organization;GO:0050769,biological_process positive regulation of neurogenesis	NUMBL; numb; K06057	NUMB like%2C endocytic adaptor protein [Source:HGNC Symbol%3BAcc:HGNC:8061]
ENSG00000137309	13.20	7.44	14.67	22.86	11.10	17.96	-0.526689037178626	2.29309737408488	0.0491954719088184	0.298029962325116	6:34236872-34246231:+	HMGA1	42;GO:0000785,cellular_component chromatin;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003680,molecular_function AT DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006284,biological_process base-excision repair;GO:0006337,biological_process nucleosome disassembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009615,biological_process response to virus;GO:0016032,biological_process viral process;GO:0019899,molecular_function enzyme binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0031936,biological_process negative regulation of chromatin silencing;GO:0035985,cellular_component senescence-associated heterochromatin focus;GO:0035986,biological_process senescence-associated heterochromatin focus assembly;GO:0042974,molecular_function retinoic acid receptor binding;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046965,molecular_function retinoid X receptor binding;GO:0051169,biological_process nuclear transport;GO:0075713,biological_process establishment of integrated proviral latency;GO:0090402,biological_process oncogene-induced cell senescence;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:2000774,biological_process positive regulation of cellular senescence	NA	high mobility group AT-hook 1 [Source:HGNC Symbol%3BAcc:HGNC:5010]
ENSG00000110711	39.34	38.05	35.98	31.69	34.01	37.08	0.151935746232381	5.33371813433231	0.0493003723296099	0.298519766696316	11:67483040-67491103:+	AIP	24;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006805,biological_process xenobiotic metabolic process;GO:0008134,molecular_function transcription factor binding;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0022417,biological_process protein maturation by protein folding;GO:0034751,cellular_component aryl hydrocarbon receptor complex;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0036004,molecular_function GAF domain binding;GO:0051082,molecular_function unfolded protein binding;GO:0051344,biological_process negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	aryl hydrocarbon receptor interacting protein [Source:HGNC Symbol%3BAcc:HGNC:358]
ENSG00000145996	9.32	9.66	9.46	11.00	10.93	10.54	-0.18046802607307	4.1583010758764	0.049327765114158	0.298540004077057	6:20534456-21232404:+	CDKAL1	19;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0035598,molecular_function N6-threonylcarbomyladenosine methylthiotransferase activity;GO:0035600,biological_process tRNA methylthiolation;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0061712,molecular_function tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase;GO:1990145,biological_process maintenance of translational fidelity	NA	CDK5 regulatory subunit associated protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:21050]
ENSG00000118523	4.72	3.65	4.22	3.65	3.55	2.48	0.407373348678126	2.01482355341172	0.0493896112437007	0.298768637606265	6:131948175-131951373:-	CTGF	66;GO:0001502,biological_process cartilage condensation;GO:0001503,biological_process ossification;GO:0001525,biological_process angiogenesis;GO:0001558,biological_process regulation of cell growth;GO:0001894,biological_process tissue homeostasis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001968,molecular_function fibronectin binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007568,biological_process aging;GO:0008022,molecular_function protein C-terminus binding;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0008544,biological_process epidermis development;GO:0009611,biological_process response to wounding;GO:0009749,biological_process response to glucose;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010942,biological_process positive regulation of cell death;GO:0014070,biological_process response to organic cyclic compound;GO:0016477,biological_process cell migration;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0032355,biological_process response to estradiol;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0034059,biological_process response to anoxia;GO:0035556,biological_process intracellular signal transduction;GO:0035988,biological_process chondrocyte proliferation;GO:0043200,biological_process response to amino acid;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043434,biological_process response to peptide hormone;GO:0045597,biological_process positive regulation of cell differentiation;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050867,biological_process positive regulation of cell activation;GO:0051385,biological_process response to mineralocorticoid;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0060401,biological_process cytosolic calcium ion transport;GO:0060452,biological_process positive regulation of cardiac muscle contraction;GO:0060548,biological_process negative regulation of cell death;GO:0061448,biological_process connective tissue development;GO:0070278,biological_process extracellular matrix constituent secretion;GO:0070318,biological_process positive regulation of G0 to G1 transition;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070542,biological_process response to fatty acid;GO:0071897,biological_process DNA biosynthetic process;GO:0072593,biological_process reactive oxygen species metabolic process	CTGF, CCN2, IGFBP8; connective tissue growth factor; K06827	connective tissue growth factor [Source:HGNC Symbol%3BAcc:HGNC:2500]
ENSG00000116198	12.28	12.07	12.70	11.96	10.95	10.81	0.14895638912649	5.1445262919746	0.0494349630045175	0.298897318935741	1:3812080-3857214:-	CEP104	11;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0016594,molecular_function glycine binding;GO:0016595,molecular_function glutamate binding;GO:0016596,molecular_function thienylcyclohexylpiperidine binding;GO:0042995,cellular_component cell projection	NA	centrosomal protein 104 [Source:HGNC Symbol%3BAcc:HGNC:24866]
ENSG00000154839	18.19	17.99	17.99	22.80	20.13	19.85	-0.200017445183738	3.91555252185861	0.0494704513526056	0.29896626710803	18:50374994-50394173:+	SKA1	20;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0031110,biological_process regulation of microtubule polymerization or depolymerization;GO:0051301,biological_process cell division	NA	spindle and kinetochore associated complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:28109]
ENSG00000185924	3.68	4.62	4.23	3.96	3.04	2.82	0.355860814799087	2.33276998423136	0.0495310361659065	0.299071747983813	17:1934676-2025345:-	RTN4RL1	25;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006501,biological_process C-terminal protein lipidation;GO:0008201,molecular_function heparin binding;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0022038,biological_process corpus callosum development;GO:0031103,biological_process axon regeneration;GO:0031225,cellular_component anchored component of membrane;GO:0035374,molecular_function chondroitin sulfate binding;GO:0042995,cellular_component cell projection;GO:0043204,cellular_component perikaryon;GO:0045121,cellular_component membrane raft;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046658,cellular_component anchored component of plasma membrane;GO:0048681,biological_process negative regulation of axon regeneration;GO:0070062,cellular_component extracellular exosome	NA	reticulon 4 receptor like 1 [Source:HGNC Symbol%3BAcc:HGNC:21329]
ENSG00000162104	5.09	4.35	5.20	5.43	5.66	5.67	-0.175200949491762	4.47127695152718	0.0495388132306044	0.299071747983813	16:3953386-4116185:-	ADCY9	27;GO:0000166,molecular_function nucleotide binding;GO:0003091,biological_process renal water homeostasis;GO:0004016,molecular_function adenylate cyclase activity;GO:0004383,molecular_function guanylate cyclase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006171,biological_process cAMP biosynthetic process;GO:0006182,biological_process cGMP biosynthetic process;GO:0007165,biological_process signal transduction;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0034199,biological_process activation of protein kinase A activity;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0071880,biological_process adenylate cyclase-activating adrenergic receptor signaling pathway	ADCY9; adenylate cyclase 9 [EC:4.6.1.1]; K08049	adenylate cyclase 9 [Source:HGNC Symbol%3BAcc:HGNC:240]
ENSG00000197580	2.56	2.80	2.75	1.81	2.49	2.06	0.359904283604888	2.1121984861535	0.0495643590026116	0.299071747983813	11:112175466-112224699:+	BCO2	18;GO:0001523,biological_process retinoid metabolic process;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0016116,biological_process carotenoid metabolic process;GO:0016119,biological_process carotene metabolic process;GO:0016121,biological_process carotene catabolic process;GO:0016122,biological_process xanthophyll metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0042573,biological_process retinoic acid metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055114,biological_process oxidation-reduction process;GO:0102076,molecular_function beta,beta-carotene-9',10'-cleaving oxygenase activity;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	NA	beta-carotene oxygenase 2 [Source:HGNC Symbol%3BAcc:HGNC:18503]
ENSG00000188060	10.48	11.25	9.79	8.93	8.12	8.92	0.282304351139407	2.67608690850081	0.0495842791710857	0.299071747983813	1:28592199-28595443:+	RAB42	4;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0016020,cellular_component membrane	NA	RAB42%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:28702]
ENSG00000176624	16.06	15.89	16.73	18.89	17.81	17.54	-0.14255114035633	5.19856975391828	0.0496168780567094	0.299123024438045	18:51174549-51218304:-	MEX3C	10;GO:0003415,biological_process chondrocyte hypertrophy;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016740,molecular_function transferase activity;GO:0045598,biological_process regulation of fat cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0097009,biological_process energy homeostasis	NA	mex-3 RNA binding family member C [Source:HGNC Symbol%3BAcc:HGNC:28040]
ENSG00000116717	101.44	78.38	100.37	117.07	89.33	125.86	-0.231006829595761	5.66933295794499	0.0497141603160843	0.299465428402312	1:67685060-67688338:+	GADD45A	30;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000185,biological_process activation of MAPKKK activity;GO:0001047,molecular_function core promoter binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007098,biological_process centrosome cycle;GO:0016607,cellular_component nuclear speck;GO:0019900,molecular_function kinase binding;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0051726,biological_process regulation of cell cycle;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071850,biological_process mitotic cell cycle arrest;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	GADD45; growth arrest and DNA-damage-inducible protein; K04402	growth arrest and DNA damage inducible alpha [Source:HGNC Symbol%3BAcc:HGNC:4095]
ENSG00000166912	16.50	17.41	16.31	17.68	19.61	18.56	-0.143908190975074	5.41851578909203	0.049721924428999	0.299465428402312	15:30938940-30991607:-	MTMR10	1;GO:0005829,cellular_component cytosol	NA	myotubularin related protein 10 [Source:HGNC Symbol%3BAcc:HGNC:25999]
ENSG00000170464	6.65	6.27	5.14	8.06	6.83	7.27	-0.285336311513723	3.02509553605672	0.0499478903380536	0.300596528389902	5:139408587-139444491:-	DNAJC18	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	DnaJ heat shock protein family (Hsp40) member C18 [Source:HGNC Symbol%3BAcc:HGNC:28429]
ENSG00000187735	328.40	239.96	350.70	417.37	289.90	411.24	-0.271217542659434	8.42141553416265	0.0499846803337536	0.300596528389902	8:53966551-54022529:-	TCEA1	16;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005730,cellular_component nucleolus;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006414,biological_process translational elongation;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	transcription elongation factor A1 [Source:HGNC Symbol%3BAcc:HGNC:11612]
ENSG00000187954	32.23	28.86	32.97	30.36	28.29	27.06	0.149930856721418	5.74932579277603	0.0500047741148523	0.300596528389902	8:144449581-144465677:-	CYHR1	8;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	cysteine and histidine rich 1 [Source:HGNC Symbol%3BAcc:HGNC:17806]
ENSG00000113758	41.76	42.52	38.19	45.40	46.28	43.68	-0.133628608812437	6.67784061700794	0.0500252398310891	0.300596528389902	5:177456607-177474401:-	DBN1	29;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005921,cellular_component gap junction;GO:0005938,cellular_component cell cortex;GO:0007015,biological_process actin filament organization;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0010643,biological_process cell communication by chemical coupling;GO:0010644,biological_process cell communication by electrical coupling;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030863,cellular_component cortical cytoskeleton;GO:0032507,biological_process maintenance of protein location in cell;GO:0042641,cellular_component actomyosin;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0048168,biological_process regulation of neuronal synaptic plasticity;GO:0048699,biological_process generation of neurons;GO:0050773,biological_process regulation of dendrite development;GO:0061351,biological_process neural precursor cell proliferation	NA	drebrin 1 [Source:HGNC Symbol%3BAcc:HGNC:2695]
ENSG00000138621	8.66	9.53	8.42	12.23	9.54	11.37	-0.314084105013292	2.64520712400513	0.0500400708417595	0.300596528389902	15:75023554-75117462:+	PPCDC	9;GO:0003824,molecular_function catalytic activity;GO:0004633,molecular_function phosphopantothenoylcysteine decarboxylase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0009108,biological_process coenzyme biosynthetic process;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0042802,molecular_function identical protein binding	PPCDC, coaC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36]; K01598	phosphopantothenoylcysteine decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:28107]
ENSG00000178695	1.96	2.16	2.94	3.15	3.27	3.32	-0.445908945109124	1.53557844607453	0.0500550249079132	0.300596528389902	13:76880165-76886390:-	KCTD12	10;GO:0003723,molecular_function RNA binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0042734,cellular_component presynaptic membrane;GO:0042802,molecular_function identical protein binding;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0051260,biological_process protein homooligomerization;GO:0070062,cellular_component extracellular exosome	NA	potassium channel tetramerization domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:14678]
ENSG00000134115	0.44	0.31	0.33	0.51	0.57	0.57	-0.56773238793847	0.762370482286152	0.0500834671404002	0.300621894397383	3:1092575-1404217:+	CNTN6	12;GO:0005112,molecular_function Notch binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007219,biological_process Notch signaling pathway;GO:0007399,biological_process nervous system development;GO:0007417,biological_process central nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022008,biological_process neurogenesis;GO:0030182,biological_process neuron differentiation;GO:0031225,cellular_component anchored component of membrane;GO:0045747,biological_process positive regulation of Notch signaling pathway	NA	contactin 6 [Source:HGNC Symbol%3BAcc:HGNC:2176]
ENSG00000167549	2.05	2.40	1.85	1.50	1.56	1.63	0.419774236858251	1.56905809651738	0.0501192048459049	0.300623680692802	17:29614755-29622907:-	CORO6	4;GO:0005515,molecular_function protein binding;GO:0015629,cellular_component actin cytoskeleton;GO:0030036,biological_process actin cytoskeleton organization;GO:0051015,molecular_function actin filament binding	NA	coronin 6 [Source:HGNC Symbol%3BAcc:HGNC:21356]
ENSG00000197713	43.74	43.98	46.22	48.63	51.21	48.62	-0.135657601946777	5.4586793335191	0.0501322016461854	0.300623680692802	2:210002564-210022259:+	RPE	15;GO:0003824,molecular_function catalytic activity;GO:0004750,molecular_function ribulose-phosphate 3-epimerase activity;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0008152,biological_process metabolic process;GO:0009052,biological_process pentose-phosphate shunt, non-oxidative branch;GO:0016853,molecular_function isomerase activity;GO:0016857,molecular_function racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0019323,biological_process pentose catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0044262,biological_process cellular carbohydrate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]; K01783	ribulose-5-phosphate-3-epimerase [Source:HGNC Symbol%3BAcc:HGNC:10293]
ENSG00000196754	62.25	49.52	65.23	68.35	63.36	74.23	-0.199130616842274	4.73616585222403	0.0501683578676688	0.300695232357012	1:153561107-153567890:-	S100A2	7;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0042802,molecular_function identical protein binding;GO:0043542,biological_process endothelial cell migration;GO:0046872,molecular_function metal ion binding;GO:0046914,molecular_function transition metal ion binding	NA	S100 calcium binding protein A2 [Source:HGNC Symbol%3BAcc:HGNC:10492]
ENSG00000101347	9.82	11.30	7.49	7.18	7.55	9.02	0.270909008154333	4.0396748632703	0.0502108632990464	0.300804751993756	20:36890228-36951843:-	SAMHD1	27;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004540,molecular_function ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006203,biological_process dGTP catabolic process;GO:0006955,biological_process immune response;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0008832,molecular_function dGTPase activity;GO:0009264,biological_process deoxyribonucleotide catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016793,molecular_function triphosphoric monoester hydrolase activity;GO:0032567,molecular_function dGTP binding;GO:0045087,biological_process innate immune response;GO:0045088,biological_process regulation of innate immune response;GO:0046061,biological_process dATP catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0090501,biological_process RNA phosphodiester bond hydrolysis	NA	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:15925]
ENSG00000068028	13.78	13.37	15.23	14.48	17.18	17.59	-0.20212484692285	4.18732323210504	0.0504448866529166	0.301969602642881	3:50329781-50340980:-	RASSF1	17;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:0070507,biological_process regulation of microtubule cytoskeleton organization	RASSF1; Ras association domain-containing protein 1; K09850	Ras association domain family member 1 [Source:HGNC Symbol%3BAcc:HGNC:9882]
ENSG00000163430	233.05	254.63	220.41	253.22	303.12	245.50	-0.168262798790319	7.86267772684884	0.0504539560042968	0.301969602642881	3:120392292-120451253:-	FSTL1	11;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0008201,molecular_function heparin binding;GO:0030509,biological_process BMP signaling pathway;GO:0042594,biological_process response to starvation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome	NA	follistatin like 1 [Source:HGNC Symbol%3BAcc:HGNC:3972]
ENSG00000111275	2.75	1.83	2.08	2.02	1.55	1.43	0.443243077292541	1.76820181726696	0.0505159181093539	0.302194742887426	12:111766886-111817529:+	ALDH2	14;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0004030,molecular_function aldehyde dehydrogenase [NAD(P)+] activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006066,biological_process alcohol metabolic process;GO:0006068,biological_process ethanol catabolic process;GO:0006069,biological_process ethanol oxidation;GO:0008152,biological_process metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]; K00128	aldehyde dehydrogenase 2 family (mitochondrial) [Source:HGNC Symbol%3BAcc:HGNC:404]
ENSG00000227500	62.17	58.92	65.91	59.61	56.71	54.73	0.143591853699391	5.55578507140863	0.0507368639381348	0.303370275560726	19:1905213-1926013:+	SCAMP4	4;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	secretory carrier membrane protein 4 [Source:HGNC Symbol%3BAcc:HGNC:30385]
ENSG00000263465	13.61	16.38	16.18	17.79	17.48	18.54	-0.216739192291416	3.83311195653647	0.0507813310043373	0.303476751395773	11:95067196-95071224:+	SRSF8	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck	SFRS2; splicing factor, arginine/serine-rich 2; K12891	serine and arginine rich splicing factor 8 [Source:HGNC Symbol%3BAcc:HGNC:16988]
ENSG00000183207	65.06	69.07	62.22	71.45	73.47	71.33	-0.129146375261629	6.78242776693806	0.0508035679852103	0.303476751395773	19:48993447-49015995:+	RUVBL2	55;GO:0000166,molecular_function nucleotide binding;GO:0000492,biological_process box C/D snoRNP assembly;GO:0000812,cellular_component Swr1 complex;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0003678,molecular_function DNA helicase activity;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005719,cellular_component nuclear euchromatin;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006457,biological_process protein folding;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031011,cellular_component Ino80 complex;GO:0031490,molecular_function chromatin DNA binding;GO:0032508,biological_process DNA duplex unwinding;GO:0034644,biological_process cellular response to UV;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043141,molecular_function ATP-dependent 5'-3' DNA helicase activity;GO:0043531,molecular_function ADP binding;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051082,molecular_function unfolded protein binding;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:0071169,biological_process establishment of protein localization to chromatin;GO:0071339,cellular_component MLL1 complex;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071733,biological_process transcriptional activation by promoter-enhancer looping;GO:0071899,biological_process negative regulation of estrogen receptor binding;GO:0097255,cellular_component R2TP complex;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	RuvB like AAA ATPase 2 [Source:HGNC Symbol%3BAcc:HGNC:10475]
ENSG00000198626	0.17	0.10	0.18	0.11	0.10	0.11	0.552777209765655	1.05388421231184	0.0508579381469098	0.303655404626066	1:237042204-237833988:+	RYR2	78;GO:0001666,biological_process response to hypoxia;GO:0002027,biological_process regulation of heart rate;GO:0003143,biological_process embryonic heart tube morphogenesis;GO:0003220,biological_process left ventricular cardiac muscle tissue morphogenesis;GO:0003300,biological_process cardiac muscle hypertrophy;GO:0005216,molecular_function ion channel activity;GO:0005219,molecular_function ryanodine-sensitive calcium-release channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005513,biological_process detection of calcium ion;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005623,cellular_component cell;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007275,biological_process multicellular organism development;GO:0010460,biological_process positive regulation of heart rate;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010882,biological_process regulation of cardiac muscle contraction by calcium ion signaling;GO:0014701,cellular_component junctional sarcoplasmic reticulum membrane;GO:0014808,biological_process release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014850,biological_process response to muscle activity;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0019722,biological_process calcium-mediated signaling;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030509,biological_process BMP signaling pathway;GO:0031000,biological_process response to caffeine;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034220,biological_process ion transmembrane transport;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0034704,cellular_component calcium channel complex;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0035994,biological_process response to muscle stretch;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0043621,molecular_function protein self-association;GO:0043924,molecular_function suramin binding;GO:0044325,molecular_function ion channel binding;GO:0048763,molecular_function calcium-induced calcium release activity;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051284,biological_process positive regulation of sequestering of calcium ion;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0051775,biological_process response to redox state;GO:0055085,biological_process transmembrane transport;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0060048,biological_process cardiac muscle contraction;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060401,biological_process cytosolic calcium ion transport;GO:0060402,biological_process calcium ion transport into cytosol;GO:0070062,cellular_component extracellular exosome;GO:0070296,biological_process sarcoplasmic reticulum calcium ion transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071313,biological_process cellular response to caffeine;GO:0071872,biological_process cellular response to epinephrine stimulus;GO:0072599,biological_process establishment of protein localization to endoplasmic reticulum;GO:0086005,biological_process ventricular cardiac muscle cell action potential;GO:0086029,biological_process Purkinje myocyte to ventricular cardiac muscle cell signaling;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0097050,biological_process type B pancreatic cell apoptotic process;GO:0097159,molecular_function organic cyclic compound binding;GO:0098735,biological_process positive regulation of the force of heart contraction;GO:0098904,biological_process regulation of AV node cell action potential;GO:0098907,biological_process regulation of SA node cell action potential;GO:0098910,biological_process regulation of atrial cardiac muscle cell action potential;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential;GO:1901896,biological_process positive regulation of calcium-transporting ATPase activity;GO:1903779,biological_process regulation of cardiac conduction	RYR2; ryanodine receptor 2; K04962	ryanodine receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:10484]
ENSG00000130021	5.95	6.83	6.20	10.54	6.56	7.54	-0.370076128467093	2.69156009412799	0.0509693001383298	0.304098384783376	X:7048919-7148190:-	PUDP	13;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process;GO:0009117,biological_process nucleotide metabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1990738,molecular_function pseudouridine 5'-phosphatase activity	NA	pseudouridine 5'-phosphatase [Source:HGNC Symbol%3BAcc:HGNC:16818]
ENSG00000187860	1.94	1.57	2.18	2.55	2.22	2.52	-0.33042709951866	2.34602081957234	0.0509811277478615	0.304098384783376	22:30356634-30378658:+	CCDC157	NA	NA	coiled-coil domain containing 157 [Source:HGNC Symbol%3BAcc:HGNC:33854]
ENSG00000159086	20.30	17.46	19.55	16.44	17.92	17.96	0.147270105341077	5.75022466224745	0.0510306100183238	0.304189330487851	21:32733898-32771858:-	PAXBP1	13;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007517,biological_process muscle organ development;GO:0008134,molecular_function transcription factor binding;GO:0014842,biological_process regulation of skeletal muscle satellite cell proliferation;GO:0031062,biological_process positive regulation of histone methylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:2000288,biological_process positive regulation of myoblast proliferation	NA	PAX3 and PAX7 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:13579]
ENSG00000205133	72.14	76.79	69.92	63.11	69.07	62.28	0.178730773616555	4.27774564364263	0.051086628587142	0.304189330487851	8:92883529-93017673:-	TRIQK	4;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	triple QxxK/R motif containing [Source:HGNC Symbol%3BAcc:HGNC:27828]
ENSG00000167615	85.61	82.81	95.92	79.47	78.71	84.55	0.135382600409165	8.070391084159	0.0510925356534259	0.304189330487851	19:54448886-54462037:+	LENG8	1;GO:0005515,molecular_function protein binding	NA	leukocyte receptor cluster member 8 [Source:HGNC Symbol%3BAcc:HGNC:15500]
ENSG00000103066	12.76	14.06	12.53	10.52	13.06	10.71	0.206607132892221	4.22481049555296	0.0510943973307959	0.304189330487851	16:68245303-68261062:+	PLA2G15	25;GO:0004622,molecular_function lysophospholipase activity;GO:0005543,molecular_function phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0006672,biological_process ceramide metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0009062,biological_process fatty acid catabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016787,molecular_function hydrolase activity;GO:0034638,biological_process phosphatidylcholine catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046338,biological_process phosphatidylethanolamine catabolic process;GO:0046470,biological_process phosphatidylcholine metabolic process;GO:0047499,molecular_function calcium-independent phospholipase A2 activity;GO:0070062,cellular_component extracellular exosome	LYPLA3; lysophospholipase III [EC:3.1.1.5]; K06129	phospholipase A2 group XV [Source:HGNC Symbol%3BAcc:HGNC:17163]
ENSG00000142279	3.83	2.82	3.14	4.18	3.94	4.42	-0.33029565483252	2.32065693794831	0.0512058589067622	0.304689847534286	19:34481637-34512304:+	WTIP	20;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001666,biological_process response to hypoxia;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007010,biological_process cytoskeleton organization;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030054,cellular_component cell junction;GO:0031047,biological_process gene silencing by RNA;GO:0035195,biological_process gene silencing by miRNA;GO:0035331,biological_process negative regulation of hippo signaling;GO:0046872,molecular_function metal ion binding;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription;GO:2000637,biological_process positive regulation of gene silencing by miRNA	AJUBA, LIMD1, WTIP; LIM domain-containing protein; K16682	WT1 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:20964]
ENSG00000133135	32.43	33.02	34.23	29.02	31.46	31.29	0.13103385075713	5.75734071689963	0.0512275607672645	0.304689847534286	X:106693793-106796993:+	RNF128	21;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0031647,biological_process regulation of protein stability;GO:0042036,biological_process negative regulation of cytokine biosynthetic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061462,biological_process protein localization to lysosome;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1904352,biological_process positive regulation of protein catabolic process in the vacuole	NA	ring finger protein 128%2C E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:21153]
ENSG00000171604	78.96	75.29	83.43	91.23	82.67	89.17	-0.133097855880616	6.33787712430739	0.0512589578990175	0.304730576820165	5:139647298-139683882:+	CXXC5	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	CXXC finger protein 5 [Source:HGNC Symbol%3BAcc:HGNC:26943]
ENSG00000101224	65.94	71.56	70.44	76.67	78.75	73.62	-0.128474683237536	6.99459987988836	0.0513882624131666	0.305188283941262	20:3786771-3806121:+	CDC25B	28;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0001556,biological_process oocyte maturation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0007144,biological_process female meiosis I;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0051301,biological_process cell division;GO:1902751,biological_process positive regulation of cell cycle G2/M phase transition	CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]; K05866	cell division cycle 25B [Source:HGNC Symbol%3BAcc:HGNC:1726]
ENSG00000185624	1136.72	1159.07	1127.68	1039.52	1107.32	1045.13	0.112756904208895	10.7959138039641	0.0514056407490729	0.305188283941262	17:81843158-81860694:-	P4HB	38;GO:0003723,molecular_function RNA binding;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0004656,molecular_function procollagen-proline 4-dioxygenase activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006457,biological_process protein folding;GO:0009897,cellular_component external side of plasma membrane;GO:0015037,molecular_function peptide disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016222,cellular_component procollagen-proline 4-dioxygenase complex;GO:0016853,molecular_function isomerase activity;GO:0018401,biological_process peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0019899,molecular_function enzyme binding;GO:0031012,cellular_component extracellular matrix;GO:0034378,biological_process chylomicron assembly;GO:0034379,biological_process very-low-density lipoprotein particle assembly;GO:0034599,biological_process cellular response to oxidative stress;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042470,cellular_component melanosome;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045454,biological_process cell redox homeostasis;GO:0046598,biological_process positive regulation of viral entry into host cell;GO:0046982,molecular_function protein heterodimerization activity;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia;GO:1902175,biological_process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	PDIA1, P4HB; protein disulfide-isomerase A1 [EC:5.3.4.1]; K09580	prolyl 4-hydroxylase subunit beta [Source:HGNC Symbol%3BAcc:HGNC:8548]
ENSG00000135437	4.22	2.20	2.39	2.43	1.35	2.14	0.599880425588253	1.33265178709583	0.0514097077033094	0.305188283941262	12:55720366-55724705:+	RDH5	12;GO:0001523,biological_process retinoid metabolic process;GO:0004745,molecular_function retinol dehydrogenase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007601,biological_process visual perception;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0042572,biological_process retinol metabolic process;GO:0044297,cellular_component cell body;GO:0050896,biological_process response to stimulus;GO:0055114,biological_process oxidation-reduction process	RDH5; 11-cis-retinol dehydrogenase [EC:1.1.1.315]; K00061	retinol dehydrogenase 5 [Source:HGNC Symbol%3BAcc:HGNC:9940]
ENSG00000169919	111.67	103.64	109.25	102.47	97.90	100.96	0.11959710164237	7.67280642780581	0.0514893913976568	0.305436181823817	7:65960683-65982314:-	GUSB	20;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004566,molecular_function beta-glucuronidase activity;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019904,molecular_function protein domain specific binding;GO:0030214,biological_process hyaluronan catabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	uidA, GUSB; beta-glucuronidase [EC:3.2.1.31]; K01195	glucuronidase beta [Source:HGNC Symbol%3BAcc:HGNC:4696]
ENSG00000106591	100.84	108.87	102.31	114.11	114.15	114.54	-0.126826130363696	5.99304457187493	0.0515132401045706	0.305436181823817	7:42932199-42948958:+	MRPL32	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015934,cellular_component large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32; K02911	mitochondrial ribosomal protein L32 [Source:HGNC Symbol%3BAcc:HGNC:14035]
ENSG00000172059	9.10	9.58	11.40	11.89	12.10	11.12	-0.208028169840197	4.07753541801769	0.0515252851638663	0.305436181823817	2:10042848-10054836:+	KLF11	22;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016604,cellular_component nuclear body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:1901653,biological_process cellular response to peptide	NA	Kruppel like factor 11 [Source:HGNC Symbol%3BAcc:HGNC:11811]
ENSG00000011021	12.28	13.22	13.02	12.15	11.75	11.18	0.144673692415679	5.18542226217914	0.0516367401210765	0.30577332193855	1:11806095-11843144:+	CLCN6	20;GO:0000166,molecular_function nucleotide binding;GO:0005216,molecular_function ion channel activity;GO:0005247,molecular_function voltage-gated chloride channel activity;GO:0005524,molecular_function ATP binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0006884,biological_process cell volume homeostasis;GO:0007165,biological_process signal transduction;GO:0009612,biological_process response to mechanical stimulus;GO:0010008,cellular_component endosome membrane;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:1902476,biological_process chloride transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport	NA	chloride voltage-gated channel 6 [Source:HGNC Symbol%3BAcc:HGNC:2024]
ENSG00000085760	30.47	28.92	29.36	34.09	30.01	34.37	-0.137578290773346	6.09384628695685	0.0516383556243343	0.30577332193855	2:55236594-55269347:-	MTIF2	15;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0032790,biological_process ribosome disassembly;GO:0043024,molecular_function ribosomal small subunit binding;GO:0070124,biological_process mitochondrial translational initiation	NA	mitochondrial translational initiation factor 2 [Source:HGNC Symbol%3BAcc:HGNC:7441]
ENSG00000110090	2.84	4.00	3.27	2.50	3.08	2.53	0.316098287959258	2.85887533595486	0.0516560586566614	0.30577332193855	11:68754619-68844410:-	CPT1A	32;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0004095,molecular_function carnitine O-palmitoyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006006,biological_process glucose metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006641,biological_process triglyceride metabolic process;GO:0006810,biological_process transport;GO:0006853,biological_process carnitine shuttle;GO:0007623,biological_process circadian rhythm;GO:0009437,biological_process carnitine metabolic process;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0032000,biological_process positive regulation of fatty acid beta-oxidation;GO:0042493,biological_process response to drug;GO:0042755,biological_process eating behavior;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046320,biological_process regulation of fatty acid oxidation;GO:0050796,biological_process regulation of insulin secretion;GO:0051260,biological_process protein homooligomerization;GO:0071398,biological_process cellular response to fatty acid;GO:1990698,molecular_function palmitoleoyltransferase activity	CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]; K08765	carnitine palmitoyltransferase 1A [Source:HGNC Symbol%3BAcc:HGNC:2328]
ENSG00000131652	39.28	35.31	35.54	44.50	39.37	39.80	-0.152530684628321	5.32520747015756	0.0517024986529892	0.305902343078911	16:3024026-3027755:+	THOC6	22;GO:0000346,cellular_component transcription export complex;GO:0000347,cellular_component THO complex;GO:0000445,cellular_component THO complex part of transcription export complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046784,biological_process viral mRNA export from host cell nucleus;GO:0051028,biological_process mRNA transport	THOC6; THO complex subunit 6; K13175	THO complex 6 [Source:HGNC Symbol%3BAcc:HGNC:28369]
ENSG00000106211	613.37	687.27	591.90	530.67	621.83	566.54	0.150239191296428	8.92895090308598	0.0517534280282368	0.306057790430921	7:76302543-76304295:+	HSPB1	50;GO:0000502,cellular_component proteasome complex;GO:0001895,biological_process retina homeostasis;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003723,molecular_function RNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006446,biological_process regulation of translational initiation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006928,biological_process movement of cell or subcellular component;GO:0006986,biological_process response to unfolded protein;GO:0008426,molecular_function protein kinase C inhibitor activity;GO:0009615,biological_process response to virus;GO:0010506,biological_process regulation of autophagy;GO:0019901,molecular_function protein kinase binding;GO:0030018,cellular_component Z disc;GO:0031012,cellular_component extracellular matrix;GO:0032731,biological_process positive regulation of interleukin-1 beta production;GO:0035556,biological_process intracellular signal transduction;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0038033,biological_process positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0042535,biological_process positive regulation of tumor necrosis factor biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043292,cellular_component contractile fiber;GO:0043488,biological_process regulation of mRNA stability;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0044183,molecular_function protein binding involved in protein folding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0099641,biological_process anterograde axonal protein transport;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1904115,cellular_component axon cytoplasm;GO:2001028,biological_process positive regulation of endothelial cell chemotaxis;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	HSPB1; heat shock protein beta-1; K04455	heat shock protein family B (small) member 1 [Source:HGNC Symbol%3BAcc:HGNC:5246]
ENSG00000101132	87.16	81.11	95.32	107.01	91.75	99.30	-0.161828639154016	5.27169880996998	0.0517974886666702	0.306172488961608	20:54207846-54228052:+	PFDN4	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0016272,cellular_component prefoldin complex;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding	NA	prefoldin subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:8868]
ENSG00000167693	37.97	37.56	36.88	41.37	40.72	41.48	-0.125015162081103	5.72651188554905	0.0518363593963627	0.30625641560545	17:799312-979770:-	NXN	16;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0016055,biological_process Wnt signaling pathway;GO:0016491,molecular_function oxidoreductase activity;GO:0030154,biological_process cell differentiation;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0045454,biological_process cell redox homeostasis;GO:0047134,molecular_function protein-disulfide reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0072358,biological_process cardiovascular system development;GO:0098869,biological_process cellular oxidant detoxification	NA	nucleoredoxin [Source:HGNC Symbol%3BAcc:HGNC:18008]
ENSG00000136895	2.50	2.58	3.62	3.36	3.59	3.79	-0.286439229440822	3.39848479747873	0.0519186498032586	0.306520604904036	9:127224264-127393660:+	GARNL3	3;GO:0005096,molecular_function GTPase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	GTPase activating Rap/RanGAP domain like 3 [Source:HGNC Symbol%3BAcc:HGNC:25425]
ENSG00000113732	392.04	450.42	382.17	343.28	417.85	325.59	0.182854516026714	6.6746230071942	0.0519304625886721	0.306520604904036	5:172983756-173035445:+	ATP6V0E1	21;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007035,biological_process vacuolar acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0016241,biological_process regulation of macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0042625,molecular_function ATPase coupled ion transmembrane transporter activity;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0090383,biological_process phagosome acidification	ATPeV0E, ATP6H; V-type H+-transporting ATPase subunit e; K02153	ATPase H+ transporting V0 subunit e1 [Source:HGNC Symbol%3BAcc:HGNC:863]
ENSG00000198874	16.40	13.71	13.57	17.01	15.78	16.71	-0.164901452029655	5.10246797167146	0.052081596908796	0.30710040737547	7:66995172-67239519:+	TYW1	11;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0008033,biological_process tRNA processing;GO:0010181,molecular_function FMN binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process	NA	tRNA-yW synthesizing protein 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:25598]
ENSG00000179218	943.30	1148.20	886.53	812.66	998.85	802.71	0.19968743896582	10.230815740596	0.0520905849778814	0.30710040737547	19:12938577-12944489:+	CALR	93;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001669,cellular_component acrosomal vesicle;GO:0001849,molecular_function complement component C1q binding;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002502,biological_process peptide antigen assembly with MHC class I protein complex;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005178,molecular_function integrin binding;GO:0005506,molecular_function iron ion binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0005925,cellular_component focal adhesion;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006457,biological_process protein folding;GO:0006611,biological_process protein export from nucleus;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0017148,biological_process negative regulation of translation;GO:0022417,biological_process protein maturation by protein folding;GO:0030246,molecular_function carbohydrate binding;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032355,biological_process response to estradiol;GO:0033018,cellular_component sarcoplasmic reticulum lumen;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0033144,biological_process negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0033574,biological_process response to testosterone;GO:0034504,biological_process protein localization to nucleus;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0040020,biological_process regulation of meiotic nuclear division;GO:0042277,molecular_function peptide binding;GO:0042493,biological_process response to drug;GO:0042562,molecular_function hormone binding;GO:0042824,cellular_component MHC class I peptide loading complex;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0044183,molecular_function protein binding involved in protein folding;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045740,biological_process positive regulation of DNA replication;GO:0045787,biological_process positive regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048387,biological_process negative regulation of retinoic acid receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050681,molecular_function androgen receptor binding;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051208,biological_process sequestering of calcium ion;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071285,biological_process cellular response to lithium ion;GO:0071310,biological_process cellular response to organic substance;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:0071682,cellular_component endocytic vesicle lumen;GO:0090398,biological_process cellular senescence;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1901164,biological_process negative regulation of trophoblast cell migration;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1990668,biological_process vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:2000510,biological_process positive regulation of dendritic cell chemotaxis	CALR; calreticulin; K08057	calreticulin [Source:HGNC Symbol%3BAcc:HGNC:1455]
ENSG00000117133	34.98	36.87	37.35	38.84	39.91	42.40	-0.140048069036882	5.36444765956246	0.0521029129084622	0.30710040737547	1:84479258-84497790:+	RPF1	12;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0019843,molecular_function rRNA binding;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042134,molecular_function rRNA primary transcript binding;GO:0042254,biological_process ribosome biogenesis	NA	ribosome production factor 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:30350]
ENSG00000100902	153.65	150.85	143.02	164.75	154.35	174.56	-0.130133373669761	7.24894745818209	0.0522520264426143	0.307685507849107	14:35278632-35317493:+	PSMA6	50;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003723,molecular_function RNA binding;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0005844,cellular_component polysome;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016363,cellular_component nuclear matrix;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019773,cellular_component proteasome core complex, alpha-subunit complex;GO:0030016,cellular_component myofibril;GO:0030017,cellular_component sarcomere;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0035639,molecular_function purine ribonucleoside triphosphate binding;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050727,biological_process regulation of inflammatory response;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051059,molecular_function NF-kappaB binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMA6; 20S proteasome subunit alpha 1 [EC:3.4.25.1]; K02730	proteasome subunit alpha 6 [Source:HGNC Symbol%3BAcc:HGNC:9535]
ENSG00000205356	4.82	5.14	5.00	4.58	4.57	4.04	0.191616455728656	4.06086864712729	0.0522603357562946	0.307685507849107	7:98214623-98252251:-	TECPR1	13;GO:0000421,cellular_component autophagosome membrane;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006914,biological_process autophagy;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0097352,biological_process autophagosome maturation	NA	tectonin beta-propeller repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:22214]
ENSG00000162819	31.39	28.06	29.91	34.92	31.49	33.48	-0.145212787094614	5.29024250872521	0.0522765436279519	0.307685507849107	1:222712552-222735196:+	BROX	2;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	NA	BRO1 domain and CAAX motif containing [Source:HGNC Symbol%3BAcc:HGNC:26512]
ENSG00000187193	23.02	25.26	35.02	34.63	30.40	42.44	-0.353792286554324	2.89180553105738	0.0523566979604074	0.307873601272685	16:56682423-56684196:+	MT1X	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0010038,biological_process response to metal ion;GO:0036018,biological_process cellular response to erythropoietin;GO:0045926,biological_process negative regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071276,biological_process cellular response to cadmium ion;GO:0071294,biological_process cellular response to zinc ion	MT1_2; metallothionein 1/2; K14739	metallothionein 1X [Source:HGNC Symbol%3BAcc:HGNC:7405]
ENSG00000102531	17.78	17.05	18.68	16.84	15.54	16.90	0.132049796626935	5.99055659078951	0.0523738441348568	0.307873601272685	13:48975911-49209779:+	FNDC3A	13;GO:0000139,cellular_component Golgi membrane;GO:0001669,cellular_component acrosomal vesicle;GO:0003723,molecular_function RNA binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007286,biological_process spermatid development;GO:0009566,biological_process fertilization;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0060009,biological_process Sertoli cell development	NA	fibronectin type III domain containing 3A [Source:HGNC Symbol%3BAcc:HGNC:20296]
ENSG00000106628	113.97	112.19	110.45	119.64	122.54	125.43	-0.115338175668198	7.47362760125866	0.052382908715694	0.307873601272685	7:44114680-44124358:-	POLD2	22;GO:0000723,biological_process telomere maintenance;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006266,biological_process DNA ligation;GO:0006271,biological_process DNA strand elongation involved in DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0019985,biological_process translesion synthesis;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043625,cellular_component delta DNA polymerase complex;GO:0071897,biological_process DNA biosynthetic process	POLD2; DNA polymerase delta subunit 2; K02328	DNA polymerase delta 2%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:9176]
ENSG00000146963	14.51	14.31	18.00	13.63	13.70	13.70	0.206216294766744	4.29519884358834	0.052448817797679	0.308073803551472	7:139340358-139423457:+	LUC7L2	10;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005685,cellular_component U1 snRNP;GO:0006376,biological_process mRNA splice site selection;GO:0016607,cellular_component nuclear speck;GO:0019899,molecular_function enzyme binding;GO:0071004,cellular_component U2-type prespliceosome	NA	LUC7 like 2%2C pre-mRNA splicing factor [Source:HGNC Symbol%3BAcc:HGNC:21608]
ENSG00000151445	16.92	16.51	19.19	20.34	19.78	19.33	-0.16027421330944	4.87287728231057	0.0524687020084213	0.308073803551472	14:77426674-77457952:-	VIPAS39	21;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007283,biological_process spermatogenesis;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0017185,biological_process peptidyl-lysine hydroxylation;GO:0030154,biological_process cell differentiation;GO:0030199,biological_process collagen fibril organization;GO:0030897,cellular_component HOPS complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032963,biological_process collagen metabolic process;GO:0043687,biological_process post-translational protein modification;GO:0055037,cellular_component recycling endosome	NA	VPS33B interacting protein%2C apical-basolateral polarity regulator%2C spe-39 homolog [Source:HGNC Symbol%3BAcc:HGNC:20347]
ENSG00000134755	2.43	2.72	3.42	3.37	3.52	3.62	-0.28172294505669	3.15119607878194	0.0524950535923604	0.308073803551472	18:31058839-31102415:-	DSC2	23;GO:0001533,cellular_component cornified envelope;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009267,biological_process cellular response to starvation;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031424,biological_process keratinization;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0086042,biological_process cardiac muscle cell-cardiac muscle cell adhesion;GO:0086073,biological_process bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086083,molecular_function cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential	DSC2; desmocollin 2; K07601	desmocollin 2 [Source:HGNC Symbol%3BAcc:HGNC:3036]
ENSG00000107372	241.19	242.94	238.58	213.22	226.19	231.74	0.118332493076774	7.53092744573953	0.0525162465411193	0.308073803551472	9:72351424-72365235:-	ZFAND5	16;GO:0001701,biological_process in utero embryonic development;GO:0001944,biological_process vasculature development;GO:0003016,biological_process respiratory system process;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0010761,biological_process fibroblast migration;GO:0046872,molecular_function metal ion binding;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048705,biological_process skeletal system morphogenesis;GO:0048745,biological_process smooth muscle tissue development;GO:0060324,biological_process face development	NA	zinc finger AN1-type containing 5 [Source:HGNC Symbol%3BAcc:HGNC:13008]
ENSG00000072756	15.08	13.72	14.70	16.37	16.53	16.40	-0.163500036308054	4.42179429672454	0.0525939784296631	0.308240847268804	3:3126915-3150879:+	TRNT1	19;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0001680,biological_process tRNA 3'-terminal CCA addition;GO:0003723,molecular_function RNA binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006396,biological_process RNA processing;GO:0008033,biological_process tRNA processing;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0034062,molecular_function RNA polymerase activity;GO:0042780,biological_process tRNA 3'-end processing;GO:0052927,molecular_function CTP:tRNA cytidylyltransferase activity;GO:0052928,molecular_function CTP:3'-cytidine-tRNA cytidylyltransferase activity;GO:0052929,molecular_function ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity;GO:1990180,biological_process mitochondrial tRNA 3'-end processing	cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]; K00974	tRNA nucleotidyl transferase 1 [Source:HGNC Symbol%3BAcc:HGNC:17341]
ENSG00000196914	30.85	29.21	31.06	27.07	27.51	29.68	0.125448507652701	7.08388738664939	0.0526120517122504	0.308240847268804	11:120336913-120489936:+	ARHGEF12	15;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome	ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12; K07532	Rho guanine nucleotide exchange factor 12 [Source:HGNC Symbol%3BAcc:HGNC:14193]
ENSG00000132793	14.31	13.68	16.47	13.47	13.23	13.48	0.161412134848951	5.18038704733092	0.0526198591177824	0.308240847268804	20:41340919-41360582:+	LPIN3	13;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0009062,biological_process fatty acid catabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0019432,biological_process triglyceride biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]; K15728	lipin 3 [Source:HGNC Symbol%3BAcc:HGNC:14451]
ENSG00000174501	2.69	2.48	2.48	1.93	2.37	2.33	0.219001743309451	3.71848670789468	0.0526440502867852	0.308240847268804	2:95836918-95991831:-	ANKRD36C	2;GO:0008200,molecular_function ion channel inhibitor activity;GO:0065009,biological_process regulation of molecular function	NA	ankyrin repeat domain 36C [Source:HGNC Symbol%3BAcc:HGNC:32946]
ENSG00000090861	285.75	207.39	288.00	324.94	267.14	323.28	-0.216944295512948	9.72847253749098	0.0526853086605265	0.308336980859555	16:70252294-70289543:-	AARS	27;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004813,molecular_function alanine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006419,biological_process alanyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0008033,biological_process tRNA processing;GO:0016020,cellular_component membrane;GO:0016597,molecular_function amino acid binding;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0043039,biological_process tRNA aminoacylation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0050885,biological_process neuromuscular process controlling balance;GO:0050905,biological_process neuromuscular process;GO:0070062,cellular_component extracellular exosome	AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]; K01872	alanyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:20]
ENSG00000204149	6.31	6.92	8.01	6.04	5.93	6.32	0.22697075187735	3.77653474313132	0.0527540388623161	0.308531024138696	10:49982189-50010499:+	AGAP6	3;GO:0005096,molecular_function GTPase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	NA	ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 6 [Source:HGNC Symbol%3BAcc:HGNC:23466]
ENSG00000104823	78.14	82.83	77.09	73.53	73.33	73.21	0.123292852868593	6.41804704121791	0.0527681756421857	0.308531024138696	19:38815421-38832005:-	ECH1	12;GO:0003824,molecular_function catalytic activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0070062,cellular_component extracellular exosome	ECH1; Delta3,5-Delta2,4-dienoyl-CoA isomerase [EC:5.3.3.21]; K12663	enoyl-CoA hydratase 1 [Source:HGNC Symbol%3BAcc:HGNC:3149]
ENSG00000055732	6.13	6.06	7.56	6.99	8.15	8.50	-0.243065104385147	3.64729946305464	0.0528388502527263	0.308798798581493	1:85018081-85048499:-	MCOLN3	10;GO:0005262,molecular_function calcium channel activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007626,biological_process locomotory behavior;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042491,biological_process auditory receptor cell differentiation;GO:0070588,biological_process calcium ion transmembrane transport	NA	mucolipin 3 [Source:HGNC Symbol%3BAcc:HGNC:13358]
ENSG00000165914	10.10	8.89	9.10	10.58	10.77	10.25	-0.15360899337869	4.89964167797284	0.0529239077373915	0.309004876652137	14:90524563-90816479:-	TTC7B	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	tetratricopeptide repeat domain 7B [Source:HGNC Symbol%3BAcc:HGNC:19858]
ENSG00000147684	152.87	148.24	156.74	170.62	160.52	170.97	-0.120801429029454	7.20129535182268	0.0529475120822933	0.309004876652137	8:124539102-124568510:+	NDUFB9	12;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0007605,biological_process sensory perception of sound;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain	NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9; K03965	NADH:ubiquinone oxidoreductase subunit B9 [Source:HGNC Symbol%3BAcc:HGNC:7704]
ENSG00000113249	241.28	280.59	246.75	270.68	334.70	269.22	-0.175024870634298	8.40532398734903	0.0529487934132841	0.309004876652137	5:157029412-157059119:-	HAVCR1	6;GO:0001618,molecular_function virus receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0031514,cellular_component motile cilium;GO:0046718,biological_process viral entry into host cell	NA	hepatitis A virus cellular receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:17866]
ENSG00000145431	32.88	32.24	34.89	36.81	36.58	37.58	-0.136393528670077	5.24995954415621	0.0530285543662801	0.309324927325486	4:156760453-156971394:-	PDGFC	35;GO:0000139,cellular_component Golgi membrane;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007171,biological_process activation of transmembrane receptor protein tyrosine kinase activity;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0007596,biological_process blood coagulation;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009790,biological_process embryo development;GO:0009887,biological_process organ morphogenesis;GO:0009986,cellular_component cell surface;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0045740,biological_process positive regulation of DNA replication;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048565,biological_process digestive tract development;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0051781,biological_process positive regulation of cell division;GO:0060348,biological_process bone development;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071230,biological_process cellular response to amino acid stimulus	PDGFC_D; platelet derived growth factor C/D; K05450	platelet derived growth factor C [Source:HGNC Symbol%3BAcc:HGNC:8801]
ENSG00000167555	6.52	4.97	6.58	7.33	7.39	6.75	-0.222799587631726	3.83912158387775	0.0530633410168291	0.30938245751146	19:52397848-52418412:+	ZNF528	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 528 [Source:HGNC Symbol%3BAcc:HGNC:29384]
ENSG00000137274	31.62	30.00	27.84	33.07	38.23	30.91	-0.179291066585675	4.9970898866046	0.0531489586002387	0.309601249403222	6:3118373-3153578:+	BPHL	8;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0009636,biological_process response to toxic substance;GO:0016787,molecular_function hydrolase activity;GO:0047658,molecular_function alpha-amino-acid esterase activity;GO:0070062,cellular_component extracellular exosome	NA	biphenyl hydrolase like [Source:HGNC Symbol%3BAcc:HGNC:1094]
ENSG00000196268	3.39	3.49	3.07	2.47	3.04	2.82	0.264011289025818	2.96328759027346	0.0531630046276741	0.309601249403222	19:21397118-21427573:+	ZNF493	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 493 [Source:HGNC Symbol%3BAcc:HGNC:23708]
ENSG00000110446	1.25	0.82	1.34	1.62	1.17	2.16	-0.507875912514533	1.40210817791442	0.0531756919139345	0.309601249403222	11:60937083-60952530:-	SLC15A3	14;GO:0005215,molecular_function transporter activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015031,biological_process protein transport;GO:0015293,molecular_function symporter activity;GO:0015333,molecular_function peptide:proton symporter activity;GO:0015833,biological_process peptide transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 15 member 3 [Source:HGNC Symbol%3BAcc:HGNC:18068]
ENSG00000035403	88.73	88.23	87.30	85.30	82.58	77.08	0.121135742484414	8.17531909000398	0.0532786563423078	0.310055302942835	10:73995192-74121363:+	VCL	53;GO:0002009,biological_process morphogenesis of an epithelium;GO:0002102,cellular_component podosome;GO:0002162,molecular_function dystroglycan binding;GO:0002576,biological_process platelet degranulation;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005623,cellular_component cell;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005915,cellular_component zonula adherens;GO:0005916,cellular_component fascia adherens;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0006936,biological_process muscle contraction;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0008013,molecular_function beta-catenin binding;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030032,biological_process lamellipodium assembly;GO:0030054,cellular_component cell junction;GO:0030055,cellular_component cell-substrate junction;GO:0030334,biological_process regulation of cell migration;GO:0030336,biological_process negative regulation of cell migration;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034333,biological_process adherens junction assembly;GO:0034394,biological_process protein localization to cell surface;GO:0034774,cellular_component secretory granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0043034,cellular_component costamere;GO:0043234,cellular_component protein complex;GO:0043297,biological_process apical junction assembly;GO:0043312,biological_process neutrophil degranulation;GO:0045294,molecular_function alpha-catenin binding;GO:0045296,molecular_function cadherin binding;GO:0048675,biological_process axon extension;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0090136,biological_process epithelial cell-cell adhesion;GO:0090636,cellular_component outer dense plaque of desmosome;GO:0090637,cellular_component inner dense plaque of desmosome;GO:1903561,cellular_component extracellular vesicle;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1990357,cellular_component terminal web	VCL; vinculin; K05700	vinculin [Source:HGNC Symbol%3BAcc:HGNC:12665]
ENSG00000109270	68.35	70.65	65.88	70.44	78.70	82.23	-0.166990871428925	4.76699030773749	0.0533495397415342	0.310248170209983	4:99878335-99894490:-	LAMTOR3	26;GO:0000165,biological_process MAPK cascade;GO:0000186,biological_process activation of MAPKK activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007050,biological_process cell cycle arrest;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0019209,molecular_function kinase activator activity;GO:0031902,cellular_component late endosome membrane;GO:0032006,biological_process regulation of TOR signaling;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032947,molecular_function protein complex scaffold;GO:0034613,biological_process cellular protein localization;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071986,cellular_component Ragulator complex	LAMTOR3, MP1, MAP2K1IP1; ragulator complex protein LAMTOR3; K04370	late endosomal/lysosomal adaptor%2C MAPK and MTOR activator 3 [Source:HGNC Symbol%3BAcc:HGNC:15606]
ENSG00000117650	33.36	35.64	33.07	36.41	39.01	37.30	-0.134254996635553	5.68157829384574	0.0533617854989376	0.310248170209983	1:211658656-211675630:-	NEK2	50;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000922,cellular_component spindle pole;GO:0001824,biological_process blastocyst development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019903,molecular_function protein phosphatase binding;GO:0030496,cellular_component midbody;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0043234,cellular_component protein complex;GO:0043392,biological_process negative regulation of DNA binding;GO:0046602,biological_process regulation of mitotic centrosome separation;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051225,biological_process spindle assembly;GO:0051299,biological_process centrosome separation;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051973,biological_process positive regulation of telomerase activity;GO:0051988,biological_process regulation of attachment of spindle microtubules to kinetochore;GO:0090307,biological_process mitotic spindle assembly;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1903126,biological_process negative regulation of centriole-centriole cohesion;GO:1904355,biological_process positive regulation of telomere capping	NA	NIMA related kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:7745]
ENSG00000075702	4.58	4.81	4.65	5.08	5.32	5.40	-0.161277624898198	4.56700815573433	0.0534084752319473	0.31037425236618	19:36054880-36105106:+	WDR62	18;GO:0000922,cellular_component spindle pole;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005682,cellular_component U5 snRNP;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007052,biological_process mitotic spindle organization;GO:0007099,biological_process centriole replication;GO:0007399,biological_process nervous system development;GO:0008380,biological_process RNA splicing;GO:0021987,biological_process cerebral cortex development;GO:0022008,biological_process neurogenesis;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	WD repeat domain 62 [Source:HGNC Symbol%3BAcc:HGNC:24502]
ENSG00000070501	10.90	8.08	8.59	13.07	9.98	10.57	-0.266307777701838	3.72836412032868	0.0535524399174676	0.310955559526071	8:42338453-42371808:+	POLB	44;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006286,biological_process base-excision repair, base-free sugar-phosphate removal;GO:0006287,biological_process base-excision repair, gap-filling;GO:0006288,biological_process base-excision repair, DNA ligation;GO:0006290,biological_process pyrimidine dimer repair;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007435,biological_process salivary gland morphogenesis;GO:0007568,biological_process aging;GO:0008017,molecular_function microtubule binding;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010332,biological_process response to gamma radiation;GO:0016445,biological_process somatic diversification of immunoglobulins;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016829,molecular_function lyase activity;GO:0019899,molecular_function enzyme binding;GO:0034061,molecular_function DNA polymerase activity;GO:0043234,cellular_component protein complex;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0048535,biological_process lymph node development;GO:0048536,biological_process spleen development;GO:0048872,biological_process homeostasis of number of cells;GO:0051402,biological_process neuron apoptotic process;GO:0055093,biological_process response to hyperoxia;GO:0071707,biological_process immunoglobulin heavy chain V-D-J recombination;GO:0071897,biological_process DNA biosynthetic process	POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]; K02330	DNA polymerase beta [Source:HGNC Symbol%3BAcc:HGNC:9174]
ENSG00000112309	2.48	2.66	1.67	2.70	3.13	3.63	-0.479136684327116	1.47819644272803	0.0535586068046999	0.310955559526071	6:70856678-70957038:-	B3GAT2	12;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0015018,molecular_function galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030204,biological_process chondroitin sulfate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050650,biological_process chondroitin sulfate proteoglycan biosynthetic process	B3GAT2; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 [EC:2.4.1.135]; K10157	beta-1%2C3-glucuronyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:922]
ENSG00000146054	1.54	0.81	1.34	1.45	2.07	1.79	-0.476968417102667	1.41624201452708	0.0535909606631085	0.310997940491429	5:181193923-181205293:-	TRIM7	6;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 7 [Source:HGNC Symbol%3BAcc:HGNC:16278]
ENSG00000005893	294.17	313.77	312.72	265.21	307.75	271.80	0.135836538598243	8.79401543040743	0.053642477083239	0.311151433660863	X:120427826-120469365:-	LAMP2	37;GO:0000421,cellular_component autophagosome membrane;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0006605,biological_process protein targeting;GO:0006914,biological_process autophagy;GO:0009267,biological_process cellular response to starvation;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017038,biological_process protein import;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031088,cellular_component platelet dense granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031647,biological_process regulation of protein stability;GO:0031902,cellular_component late endosome membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0044754,cellular_component autolysosome;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0050821,biological_process protein stabilization;GO:0061684,biological_process chaperone-mediated autophagy;GO:0061740,biological_process protein targeting to lysosome involved in chaperone-mediated autophagy;GO:0070062,cellular_component extracellular exosome;GO:0097352,biological_process autophagosome maturation;GO:0097637,cellular_component integral component of autophagosome membrane;GO:0098857,cellular_component membrane microdomain;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1905146,biological_process lysosomal protein catabolic process	LAMP1_2, CD107; lysosomal-associated membrane protein 1/2; K06528	lysosomal associated membrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6501]
ENSG00000168906	359.92	345.28	371.98	393.80	384.20	397.01	-0.113326957626114	8.79970509289352	0.0537719946966656	0.311754549035759	2:85539164-85545280:+	MAT2A	15;GO:0000166,molecular_function nucleotide binding;GO:0004478,molecular_function methionine adenosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006556,biological_process S-adenosylmethionine biosynthetic process;GO:0006730,biological_process one-carbon metabolic process;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0034214,biological_process protein hexamerization;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0048269,cellular_component methionine adenosyltransferase complex;GO:0051291,biological_process protein heterooligomerization;GO:1990830,biological_process cellular response to leukemia inhibitory factor	metK; S-adenosylmethionine synthetase [EC:2.5.1.6]; K00789	methionine adenosyltransferase 2A [Source:HGNC Symbol%3BAcc:HGNC:6904]
ENSG00000146039	0.54	0.79	0.84	0.19	0.63	0.45	0.771422032570876	0.0555175587852462	0.0538152432324032	0.311754549035759	6:25754698-25781191:+	SLC17A4	14;GO:0005436,molecular_function sodium:phosphate symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0015293,molecular_function symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 17 member 4 [Source:HGNC Symbol%3BAcc:HGNC:10932]
ENSG00000179262	95.59	91.00	95.36	88.83	81.83	89.69	0.127526267930713	6.62440776266399	0.0538517210608725	0.311754549035759	19:12945854-12953642:+	RAD23A	24;GO:0000502,cellular_component proteasome complex;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0019900,molecular_function kinase binding;GO:0031593,molecular_function polyubiquitin binding;GO:0031648,biological_process protein destabilization;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045787,biological_process positive regulation of cell cycle;GO:1990381,molecular_function ubiquitin-specific protease binding	RAD23, HR23; UV excision repair protein RAD23; K10839	RAD23 homolog A%2C nucleotide excision repair protein [Source:HGNC Symbol%3BAcc:HGNC:9812]
ENSG00000124201	15.94	15.89	15.84	17.48	16.98	17.74	-0.119460402963506	6.71186593879421	0.0538553775782926	0.311754549035759	20:49237945-49278426:-	ZNFX1	6;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger NFX1-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29271]
ENSG00000184428	28.16	28.58	27.66	31.53	29.46	31.74	-0.125215142389637	5.9906395610228	0.0538720299429391	0.311754549035759	8:143304383-143359979:-	TOP1MT	10;GO:0003677,molecular_function DNA binding;GO:0003916,molecular_function DNA topoisomerase activity;GO:0003917,molecular_function DNA topoisomerase type I activity;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005739,cellular_component mitochondrion;GO:0006260,biological_process DNA replication;GO:0006265,biological_process DNA topological change;GO:0016853,molecular_function isomerase activity;GO:0042645,cellular_component mitochondrial nucleoid	NA	topoisomerase (DNA) I%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:29787]
ENSG00000188917	12.38	13.40	13.19	11.88	10.73	12.00	0.178142760451697	4.22275719738723	0.0539255374703304	0.311918777548561	X:101009345-101052116:-	TRMT2B	10;GO:0001510,biological_process RNA methylation;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006396,biological_process RNA processing;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030697,molecular_function S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity;GO:0032259,biological_process methylation	NA	tRNA methyltransferase 2 homolog B [Source:HGNC Symbol%3BAcc:HGNC:25748]
ENSG00000185875	10.80	10.38	9.38	10.92	11.50	12.27	-0.172826410722675	4.61062551448938	0.0539849862195349	0.312117202581782	10:25016657-25026664:+	THNSL1	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	threonine synthase like 1 [Source:HGNC Symbol%3BAcc:HGNC:26160]
ENSG00000110237	11.69	12.02	12.59	11.54	11.14	10.85	0.126385243593015	6.22767993307286	0.0540599815666963	0.312405284537896	11:73308288-73369091:+	ARHGEF17	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005829,cellular_component cytosol;GO:0030036,biological_process actin cytoskeleton organization;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho guanine nucleotide exchange factor 17 [Source:HGNC Symbol%3BAcc:HGNC:21726]
ENSG00000173599	14.98	14.49	13.79	12.75	12.53	14.28	0.1397907865327	5.69957499685534	0.0540864663118705	0.312412892661354	11:66848232-66958376:-	PC	22;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004075,molecular_function biotin carboxylase activity;GO:0004736,molecular_function pyruvate carboxylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006090,biological_process pyruvate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006629,biological_process lipid metabolic process;GO:0006768,biological_process biotin metabolic process;GO:0008152,biological_process metabolic process;GO:0009374,molecular_function biotin binding;GO:0010629,biological_process negative regulation of gene expression;GO:0016874,molecular_function ligase activity;GO:0019074,biological_process viral RNA genome packaging;GO:0044791,biological_process positive regulation by host of viral release from host cell;GO:0044794,biological_process positive regulation by host of viral process;GO:0046872,molecular_function metal ion binding	PC, pyc; pyruvate carboxylase [EC:6.4.1.1]; K01958	pyruvate carboxylase [Source:HGNC Symbol%3BAcc:HGNC:8636]
ENSG00000120733	24.45	26.08	24.27	27.82	28.47	26.09	-0.128343426287096	7.11485236046347	0.054178717200835	0.312800193773937	5:138352595-138437028:+	KDM3B	18;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0031490,molecular_function chromatin DNA binding;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0072718,biological_process response to cisplatin;GO:0098869,biological_process cellular oxidant detoxification	KDM3; [histone H3]-dimethyl-L-lysine9 demethylase [EC:1.14.11.65]; K15601	lysine demethylase 3B [Source:HGNC Symbol%3BAcc:HGNC:1337]
ENSG00000100296	16.85	17.88	16.36	19.07	18.79	18.73	-0.139414284806841	5.2821962823663	0.0542189666334649	0.31288704454728	22:29505878-29555216:-	THOC5	24;GO:0000346,cellular_component transcription export complex;GO:0000347,cellular_component THO complex;GO:0000445,cellular_component THO complex part of transcription export complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0030154,biological_process cell differentiation;GO:0030224,biological_process monocyte differentiation;GO:0031124,biological_process mRNA 3'-end processing;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0046784,biological_process viral mRNA export from host cell nucleus;GO:0051028,biological_process mRNA transport;GO:0060215,biological_process primitive hemopoiesis;GO:2000002,biological_process negative regulation of DNA damage checkpoint	THOC5; THO complex subunit 5; K13174	THO complex 5 [Source:HGNC Symbol%3BAcc:HGNC:19074]
ENSG00000167642	154.77	139.20	158.94	173.71	154.77	175.14	-0.140031043192135	7.18243853689026	0.0542450150293937	0.312891901282465	19:38244034-38292614:+	SPINT2	19;GO:0001843,biological_process neural tube closure;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030414,molecular_function peptidase inhibitor activity;GO:0060672,biological_process epithelial cell morphogenesis involved in placental branching;GO:0071711,biological_process basement membrane organization;GO:0071773,biological_process cellular response to BMP stimulus;GO:2000146,biological_process negative regulation of cell motility;GO:2000178,biological_process negative regulation of neural precursor cell proliferation	NA	serine peptidase inhibitor%2C Kunitz type 2 [Source:HGNC Symbol%3BAcc:HGNC:11247]
ENSG00000166349	0.25	0.40	0.19	0.36	0.44	0.54	-0.713053191191871	0.355522166910824	0.0543108312250759	0.313126032511318	11:36510708-36593156:+	RAG1	38;GO:0002250,biological_process adaptive immune response;GO:0002331,biological_process pre-B cell allelic exclusion;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006310,biological_process DNA recombination;GO:0006955,biological_process immune response;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0008542,biological_process visual learning;GO:0010390,biological_process histone monoubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0030183,biological_process B cell differentiation;GO:0033077,biological_process T cell differentiation in thymus;GO:0033151,biological_process V(D)J recombination;GO:0042393,molecular_function histone binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043029,biological_process T cell homeostasis;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045580,biological_process regulation of T cell differentiation;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048538,biological_process thymus development;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070233,biological_process negative regulation of T cell apoptotic process;GO:0070244,biological_process negative regulation of thymocyte apoptotic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:2000822,biological_process regulation of behavioral fear response	RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]; K10628	recombination activating 1 [Source:HGNC Symbol%3BAcc:HGNC:9831]
ENSG00000197818	7.18	7.04	7.64	8.28	8.17	8.83	-0.196220633510241	3.83485024235852	0.054345415190164	0.31312680710337	20:49812712-49892242:+	SLC9A8	19;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006885,biological_process regulation of pH;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015386,molecular_function potassium:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	solute carrier family 9 member A8 [Source:HGNC Symbol%3BAcc:HGNC:20728]
ENSG00000158669	30.19	32.83	31.30	27.74	29.15	29.49	0.134820320270847	5.3719820270081	0.0543614170069897	0.31312680710337	8:41577186-41625001:+	GPAT4	25;GO:0002071,biological_process glandular epithelial cell maturation;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366,molecular_function glycerol-3-phosphate O-acyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0007595,biological_process lactation;GO:0008152,biological_process metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019432,biological_process triglyceride biosynthetic process;GO:0030879,biological_process mammary gland development;GO:0040014,biological_process regulation of multicellular organism growth;GO:0046339,biological_process diacylglycerol metabolic process;GO:0102420,molecular_function sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	GPAT3_4, AGPAT9, AGPAT6; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]; K13506	glycerol-3-phosphate acyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:20880]
ENSG00000134897	1.11	1.44	1.59	0.93	0.84	1.10	0.519935031545836	0.945866474780981	0.0543960443313997	0.313180936125076	13:102799048-102841535:+	BIVM	4;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm	NA	basic%2C immunoglobulin-like variable motif containing [Source:HGNC Symbol%3BAcc:HGNC:16034]
ENSG00000162981	2.18	3.05	2.77	1.11	1.90	2.41	0.548619449854319	1.06460708025067	0.0546200618349902	0.314324908464411	2:14632685-14650814:+	FAM84A	NA	NA	family with sequence similarity 84 member A [Source:HGNC Symbol%3BAcc:HGNC:20743]
ENSG00000116171	70.96	77.87	70.59	65.05	70.67	66.06	0.131153525508983	6.88786218856364	0.0546788138403286	0.314517199351251	1:52927228-53051703:+	SCP2	35;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0003824,molecular_function catalytic activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006694,biological_process steroid biosynthetic process;GO:0006699,biological_process bile acid biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0007031,biological_process peroxisome organization;GO:0008152,biological_process metabolic process;GO:0008289,molecular_function lipid binding;GO:0015248,molecular_function sterol transporter activity;GO:0015485,molecular_function cholesterol binding;GO:0015914,biological_process phospholipid transport;GO:0015918,biological_process sterol transport;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0032385,biological_process positive regulation of intracellular cholesterol transport;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0033814,molecular_function propanoyl-CoA C-acyltransferase activity;GO:0036042,molecular_function long-chain fatty acyl-CoA binding;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0050632,molecular_function propionyl-CoA C2-trimethyltridecanoyltransferase activity;GO:0070062,cellular_component extracellular exosome;GO:0070538,molecular_function oleic acid binding;GO:1901373,biological_process lipid hydroperoxide transport	SCP2, SCPX; sterol carrier protein 2 [EC:2.3.1.176]; K08764	sterol carrier protein 2 [Source:HGNC Symbol%3BAcc:HGNC:10606]
ENSG00000085999	8.37	9.42	7.71	10.01	9.30	9.87	-0.190349487773119	4.36891066837289	0.0547776249334617	0.314804119376131	1:46247687-46278473:+	RAD54L	21;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000733,biological_process DNA strand renaturation;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008340,biological_process determination of adult lifespan;GO:0010212,biological_process response to ionizing radiation;GO:0016787,molecular_function hydrolase activity;GO:0036310,molecular_function annealing helicase activity;GO:0042493,biological_process response to drug;GO:0043234,cellular_component protein complex;GO:0051276,biological_process chromosome organization;GO:0051321,biological_process meiotic cell cycle	RAD54L, RAD54; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-]; K10875	RAD54 like (S. cerevisiae) [Source:HGNC Symbol%3BAcc:HGNC:9826]
ENSG00000092820	187.90	185.95	181.30	201.27	199.08	203.49	-0.109571775766859	8.41892769911645	0.0547876606136752	0.314804119376131	6:158765740-158819412:-	EZR	98;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001650,cellular_component fibrillar center;GO:0001726,cellular_component ruffle;GO:0001772,cellular_component immunological synapse;GO:0001931,cellular_component uropod;GO:0001951,biological_process intestinal D-glucose absorption;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005903,cellular_component brush border;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007411,biological_process axon guidance;GO:0008017,molecular_function microtubule binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008360,biological_process regulation of cell shape;GO:0010628,biological_process positive regulation of gene expression;GO:0010737,biological_process protein kinase A signaling;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019898,cellular_component extrinsic component of membrane;GO:0019904,molecular_function protein domain specific binding;GO:0022614,biological_process membrane to membrane docking;GO:0030033,biological_process microvillus assembly;GO:0030175,cellular_component filopodium;GO:0030315,cellular_component T-tubule;GO:0030855,biological_process epithelial cell differentiation;GO:0030863,cellular_component cortical cytoskeleton;GO:0030953,biological_process astral microtubule organization;GO:0031528,cellular_component microvillus membrane;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031623,biological_process receptor internalization;GO:0031982,cellular_component vesicle;GO:0032403,molecular_function protein complex binding;GO:0032532,biological_process regulation of microvillus length;GO:0032587,cellular_component ruffle membrane;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0034629,biological_process cellular protein complex localization;GO:0035088,biological_process establishment or maintenance of apical/basal cell polarity;GO:0036064,cellular_component ciliary basal body;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0043622,biological_process cortical microtubule organization;GO:0044297,cellular_component cell body;GO:0044393,cellular_component microspike;GO:0044548,molecular_function S100 protein binding;GO:0044853,cellular_component plasma membrane raft;GO:0045121,cellular_component membrane raft;GO:0045177,cellular_component apical part of cell;GO:0045296,molecular_function cadherin binding;GO:0046847,biological_process filopodium assembly;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050714,biological_process positive regulation of protein secretion;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051117,molecular_function ATPase binding;GO:0051286,cellular_component cell tip;GO:0051660,biological_process establishment of centrosome localization;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071320,biological_process cellular response to cAMP;GO:0071437,cellular_component invadopodium;GO:0071944,cellular_component cell periphery;GO:0072697,biological_process protein localization to cell cortex;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0097449,cellular_component astrocyte projection;GO:0097454,cellular_component Schwann cell microvillus;GO:0097718,molecular_function disordered domain specific binding;GO:0098592,cellular_component cytoplasmic side of apical plasma membrane;GO:1900041,biological_process negative regulation of interleukin-2 secretion;GO:1902115,biological_process regulation of organelle assembly;GO:1902896,biological_process terminal web assembly;GO:1902966,biological_process positive regulation of protein localization to early endosome;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:1903753,biological_process negative regulation of p38MAPK cascade;GO:2000643,biological_process positive regulation of early endosome to late endosome transport	VIL2; villin 2 (ezrin); K08007	ezrin [Source:HGNC Symbol%3BAcc:HGNC:12691]
ENSG00000162337	19.92	21.35	20.97	19.46	19.06	19.07	0.122845679709364	6.63243899578736	0.0548047774085088	0.314804119376131	11:68312608-68449275:+	LRP5	61;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001944,biological_process vasculature development;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002076,biological_process osteoblast development;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006007,biological_process glucose catabolic process;GO:0006897,biological_process endocytosis;GO:0007275,biological_process multicellular organism development;GO:0008203,biological_process cholesterol metabolic process;GO:0008217,biological_process regulation of blood pressure;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009314,biological_process response to radiation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0033690,biological_process positive regulation of osteoblast proliferation;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035108,biological_process limb morphogenesis;GO:0035426,biological_process extracellular matrix-cell signaling;GO:0042074,biological_process cell migration involved in gastrulation;GO:0042632,biological_process cholesterol homeostasis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043235,cellular_component receptor complex;GO:0043434,biological_process response to peptide hormone;GO:0044332,biological_process Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046849,biological_process bone remodeling;GO:0046850,biological_process regulation of bone remodeling;GO:0048539,biological_process bone marrow development;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060033,biological_process anatomical structure regression;GO:0060042,biological_process retina morphogenesis in camera-type eye;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060348,biological_process bone development;GO:0060349,biological_process bone morphogenesis;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0060603,biological_process mammary gland duct morphogenesis;GO:0060612,biological_process adipose tissue development;GO:0060764,biological_process cell-cell signaling involved in mammary gland development;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0061299,biological_process retina vasculature morphogenesis in camera-type eye;GO:0061304,biological_process retinal blood vessel morphogenesis;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0071936,molecular_function coreceptor activity involved in Wnt signaling pathway;GO:1902262,biological_process apoptotic process involved in patterning of blood vessels;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:1904928,molecular_function coreceptor activity involved in canonical Wnt signaling pathway;GO:1990851,cellular_component Wnt-Frizzled-LRP5/6 complex;GO:1990909,cellular_component Wnt signalosome	LRP5_6; low density lipoprotein receptor-related protein 5/6; K03068	LDL receptor related protein 5 [Source:HGNC Symbol%3BAcc:HGNC:6697]
ENSG00000112984	41.50	45.28	35.97	43.07	51.93	44.64	-0.175593460217643	6.86931065797494	0.0548697676153634	0.315031649125581	5:138178718-138187715:+	KIF20A	25;GO:0000166,molecular_function nucleotide binding;GO:0000281,biological_process mitotic cytokinesis;GO:0000910,biological_process cytokinesis;GO:0000920,biological_process cell separation after cytokinesis;GO:0001578,biological_process microtubule bundle formation;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0016887,molecular_function ATPase activity;GO:0019901,molecular_function protein kinase binding;GO:0030496,cellular_component midbody	NA	kinesin family member 20A [Source:HGNC Symbol%3BAcc:HGNC:9787]
ENSG00000189339	15.27	16.04	14.95	13.06	12.11	15.32	0.198399147706189	4.15285721122158	0.0549591415378106	0.315398901483515	1:1659528-1692728:-	SLC35E2B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member E2B [Source:HGNC Symbol%3BAcc:HGNC:33941]
ENSG00000169418	3.13	2.67	2.89	4.21	3.12	3.29	-0.271074662502148	3.38509880953203	0.0550717036083904	0.315739642906996	1:153678636-153693992:+	NPR1	39;GO:0000166,molecular_function nucleotide binding;GO:0004383,molecular_function guanylate cyclase activity;GO:0004672,molecular_function protein kinase activity;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006182,biological_process cGMP biosynthetic process;GO:0006468,biological_process protein phosphorylation;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007168,biological_process receptor guanylyl cyclase signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007589,biological_process body fluid secretion;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0008217,biological_process regulation of blood pressure;GO:0008528,molecular_function G-protein coupled peptide receptor activity;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0016941,molecular_function natriuretic peptide receptor activity;GO:0017046,molecular_function peptide hormone binding;GO:0019901,molecular_function protein kinase binding;GO:0030308,biological_process negative regulation of cell growth;GO:0030828,biological_process positive regulation of cGMP biosynthetic process;GO:0035556,biological_process intracellular signal transduction;GO:0035810,biological_process positive regulation of urine volume;GO:0035815,biological_process positive regulation of renal sodium excretion;GO:0042417,biological_process dopamine metabolic process;GO:0042562,molecular_function hormone binding;GO:0043114,biological_process regulation of vascular permeability;GO:0043235,cellular_component receptor complex;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050880,biological_process regulation of blood vessel size;GO:0097746,biological_process regulation of blood vessel diameter;GO:1903779,biological_process regulation of cardiac conduction	ANPRA, NPR1; atrial natriuretic peptide receptor A [EC:4.6.1.2]; K12323	natriuretic peptide receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:7943]
ENSG00000257923	24.64	24.15	25.40	23.51	22.50	22.89	0.11926538796873	7.00003237705047	0.0550758811220789	0.315739642906996	7:101815903-102283957:+	CUX1	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000139,cellular_component Golgi membrane;GO:0000301,biological_process retrograde transport, vesicle recycling within Golgi;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030674,molecular_function protein binding, bridging;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048193,biological_process Golgi vesicle transport;GO:0050775,biological_process positive regulation of dendrite morphogenesis	NA	cut like homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:2557]
ENSG00000171680	4.38	3.39	3.80	3.37	2.78	3.67	0.255314239882175	3.69635960640338	0.0550948253070614	0.315739642906996	1:6466091-6520061:-	PLEKHG5	21;GO:0004871,molecular_function signal transducer activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035767,biological_process endothelial cell chemotaxis;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043542,biological_process endothelial cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	pleckstrin homology and RhoGEF domain containing G5 [Source:HGNC Symbol%3BAcc:HGNC:29105]
ENSG00000163661	4.02	2.34	3.86	2.36	2.65	2.71	0.440494483008462	1.85034782260586	0.0551421007320334	0.315748817520307	3:157436788-157443628:+	PTX3	21;GO:0001849,molecular_function complement component C1q binding;GO:0001872,molecular_function (1->3)-beta-D-glucan binding;GO:0001878,biological_process response to yeast;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006954,biological_process inflammatory response;GO:0008228,biological_process opsonization;GO:0035580,cellular_component specific granule lumen;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation;GO:0044869,biological_process negative regulation by host of viral exo-alpha-sialidase activity;GO:0044871,biological_process negative regulation by host of viral glycoprotein metabolic process;GO:0045087,biological_process innate immune response;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046790,molecular_function virion binding;GO:0050766,biological_process positive regulation of phagocytosis;GO:1903016,biological_process negative regulation of exo-alpha-sialidase activity;GO:1903019,biological_process negative regulation of glycoprotein metabolic process;GO:1904724,cellular_component tertiary granule lumen	NA	pentraxin 3 [Source:HGNC Symbol%3BAcc:HGNC:9692]
ENSG00000198648	22.94	18.82	20.93	25.05	20.55	26.75	-0.191537104094126	5.2129598296973	0.0551473001195541	0.315748817520307	2:167954019-168248141:-	STK39	47;GO:0000166,molecular_function nucleotide binding;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008217,biological_process regulation of blood pressure;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019898,cellular_component extrinsic component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0023016,biological_process signal transduction by trans-phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0032414,biological_process positive regulation of ion transmembrane transporter activity;GO:0035556,biological_process intracellular signal transduction;GO:0036438,biological_process maintenance of lens transparency;GO:0042981,biological_process regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043268,biological_process positive regulation of potassium ion transport;GO:0046777,biological_process protein autophosphorylation;GO:0050727,biological_process regulation of inflammatory response;GO:0071476,biological_process cellular hypotonic response;GO:0090188,biological_process negative regulation of pancreatic juice secretion;GO:1901017,biological_process negative regulation of potassium ion transmembrane transporter activity;GO:1901380,biological_process negative regulation of potassium ion transmembrane transport;GO:1905408,biological_process negative regulation of creatine transmembrane transporter activity;GO:2000021,biological_process regulation of ion homeostasis;GO:2000650,biological_process negative regulation of sodium ion transmembrane transporter activity;GO:2000681,biological_process negative regulation of rubidium ion transport;GO:2000687,biological_process negative regulation of rubidium ion transmembrane transporter activity	NA	serine/threonine kinase 39 [Source:HGNC Symbol%3BAcc:HGNC:17717]
ENSG00000117479	6.35	6.60	4.99	5.27	4.98	4.57	0.279517088401984	3.04419286097773	0.0551849315251669	0.315818605358182	1:169463908-169486003:-	SLC19A2	12;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008517,molecular_function folic acid transporter activity;GO:0015234,molecular_function thiamine transmembrane transporter activity;GO:0015403,molecular_function thiamine uptake transmembrane transporter activity;GO:0015884,biological_process folic acid transport;GO:0015888,biological_process thiamine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042723,biological_process thiamine-containing compound metabolic process;GO:0071934,biological_process thiamine transmembrane transport	SLC19A2_3, THTR; solute carrier family 19 (thiamine transporter), member 2/3; K14610	solute carrier family 19 member 2 [Source:HGNC Symbol%3BAcc:HGNC:10938]
ENSG00000168538	8.85	8.85	9.16	9.60	10.43	9.90	-0.143826700912973	5.02685380097938	0.0552517855114238	0.31605549011673	4:183659266-183713594:+	TRAPPC11	13;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051259,biological_process protein oligomerization;GO:0061024,biological_process membrane organization;GO:0061635,biological_process regulation of protein complex stability	NA	trafficking protein particle complex 11 [Source:HGNC Symbol%3BAcc:HGNC:25751]
ENSG00000158864	65.05	65.59	60.99	68.96	72.12	69.57	-0.125609043097329	6.56185311452341	0.0552842561809488	0.316095565165415	1:161197103-161214395:+	NDUFS2	24;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005759,cellular_component mitochondrial matrix;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006979,biological_process response to oxidative stress;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0042775,biological_process mitochondrial ATP synthesis coupled electron transport;GO:0046872,molecular_function metal ion binding;GO:0048038,molecular_function quinone binding;GO:0051287,molecular_function NAD binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2 1.6.99.3]; K03935	NADH:ubiquinone oxidoreductase core subunit S2 [Source:HGNC Symbol%3BAcc:HGNC:7708]
ENSG00000152359	3.82	4.37	4.84	3.34	4.02	3.41	0.285963154193241	2.85629508589108	0.0554140246611087	0.31669166119629	5:75674123-75717481:-	POC5	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle	NA	POC5 centriolar protein [Source:HGNC Symbol%3BAcc:HGNC:26658]
ENSG00000100243	137.39	147.04	143.89	130.57	139.45	124.83	0.128612376747087	7.13482058157693	0.0555677024599245	0.317423787682946	22:42617839-42649568:-	CYB5R3	29;GO:0004128,molecular_function cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0005833,cellular_component hemoglobin complex;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0008015,biological_process blood circulation;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0016020,cellular_component membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016208,molecular_function AMP binding;GO:0016491,molecular_function oxidoreductase activity;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043531,molecular_function ADP binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	E1.6.2.2; cytochrome-b5 reductase [EC:1.6.2.2]; K00326	cytochrome b5 reductase 3 [Source:HGNC Symbol%3BAcc:HGNC:2873]
ENSG00000153822	73.49	72.14	71.74	56.30	75.57	62.59	0.172740474780469	6.5714272744764	0.0556262269308842	0.317611938773259	17:70053428-70135608:+	KCNJ16	15;GO:0005242,molecular_function inward rectifier potassium channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0010107,biological_process potassium ion import;GO:0015467,molecular_function G-protein activated inward rectifier potassium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport	KCNJ16, KIR5.1; potassium inwardly-rectifying channel subfamily J member 16; K05009	potassium voltage-gated channel subfamily J member 16 [Source:HGNC Symbol%3BAcc:HGNC:6262]
ENSG00000109321	5.34	4.19	4.76	7.13	4.07	8.78	-0.468478443292113	2.4417096811502	0.0557029689731924	0.317748280742065	4:74445133-74455009:+	AREG	38;GO:0000139,cellular_component Golgi membrane;GO:0005125,molecular_function cytokine activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0008083,molecular_function growth factor activity;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0014009,biological_process glial cell proliferation;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031175,biological_process neuron projection development;GO:0032355,biological_process response to estradiol;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042542,biological_process response to hydrogen peroxide;GO:0043434,biological_process response to peptide hormone;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045740,biological_process positive regulation of DNA replication;GO:0048208,biological_process COPII vesicle coating;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051384,biological_process response to glucocorticoid;GO:0051591,biological_process response to cAMP;GO:0060598,biological_process dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis;GO:0060744,biological_process mammary gland branching involved in thelarche;GO:0060749,biological_process mammary gland alveolus development;GO:0060750,biological_process epithelial cell proliferation involved in mammary gland duct elongation	AREG; amphiregulin; K09782	amphiregulin [Source:HGNC Symbol%3BAcc:HGNC:651]
ENSG00000147509	27.27	26.74	27.40	30.60	29.16	30.45	-0.135752365532537	5.14867373199367	0.0557237545929702	0.317748280742065	8:53851807-53959303:+	RGS20	11;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity	NA	regulator of G protein signaling 20 [Source:HGNC Symbol%3BAcc:HGNC:14600]
ENSG00000184384	6.06	6.22	6.85	5.69	5.46	5.96	0.172971745579491	4.40092487115485	0.0557268997966225	0.317748280742065	11:95976597-96343180:-	MAML2	10;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007219,biological_process Notch signaling pathway;GO:0007221,biological_process positive regulation of transcription of Notch receptor target;GO:0016607,cellular_component nuclear speck;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	MAML; mastermind; K06061	mastermind like transcriptional coactivator 2 [Source:HGNC Symbol%3BAcc:HGNC:16259]
ENSG00000064199	20.74	21.52	16.41	23.47	26.45	21.27	-0.272087563833418	3.31448317135866	0.055814408062842	0.318101123638227	11:124673797-124697518:+	SPA17	12;GO:0003351,biological_process epithelial cilium movement;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0031514,cellular_component motile cilium;GO:0035686,cellular_component sperm fibrous sheath;GO:0097228,cellular_component sperm principal piece	NA	sperm autoantigenic protein 17 [Source:HGNC Symbol%3BAcc:HGNC:11210]
ENSG00000141576	7.22	8.36	7.56	7.19	6.74	6.28	0.200387050479884	3.92745475404854	0.0560827213657244	0.319483625659815	17:76142452-76240373:-	RNF157	1;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 157 [Source:HGNC Symbol%3BAcc:HGNC:29402]
ENSG00000138190	4.02	3.62	4.33	4.69	4.49	4.92	-0.218142970263349	3.51630861673679	0.0561293472095261	0.319602562803599	10:92834712-93059493:+	EXOC6	13;GO:0000145,cellular_component exocyst;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0015031,biological_process protein transport;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0042995,cellular_component cell projection;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	exocyst complex component 6 [Source:HGNC Symbol%3BAcc:HGNC:23196]
ENSG00000023330	31.46	35.90	34.69	33.02	30.19	30.03	0.139789903287722	6.03202724397046	0.0561884290968612	0.319792283530187	3:52198085-52214327:+	ALAS1	19;GO:0003824,molecular_function catalytic activity;GO:0003870,molecular_function 5-aminolevulinate synthase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006778,biological_process porphyrin-containing compound metabolic process;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0007005,biological_process mitochondrion organization;GO:0008152,biological_process metabolic process;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0033014,biological_process tetrapyrrole biosynthetic process;GO:0042802,molecular_function identical protein binding	E2.3.1.37, ALAS; 5-aminolevulinate synthase [EC:2.3.1.37]; K00643	5'-aminolevulinate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:396]
ENSG00000103044	22.10	22.92	22.53	26.78	23.52	24.79	-0.142453931785948	5.39661959145048	0.0562622544080795	0.320065703009849	16:69105563-69118719:+	HAS3	16;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030213,biological_process hyaluronan biosynthetic process;GO:0036117,cellular_component hyaluranon cable;GO:0045226,biological_process extracellular polysaccharide biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050501,molecular_function hyaluronan synthase activity;GO:0085029,biological_process extracellular matrix assembly;GO:1900106,biological_process positive regulation of hyaluranon cable assembly	NA	hyaluronan synthase 3 [Source:HGNC Symbol%3BAcc:HGNC:4820]
ENSG00000149308	6.71	6.79	5.85	5.78	6.18	5.30	0.175013178737087	4.76640614629566	0.0562887278990969	0.320069619519693	11:108157214-108222642:-	NPAT	17;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0010468,biological_process regulation of gene expression;GO:0015030,cellular_component Cajal body;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0097504,cellular_component Gemini of coiled bodies;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	nuclear protein%2C coactivator of histone transcription [Source:HGNC Symbol%3BAcc:HGNC:7896]
ENSG00000232653	1.85	1.91	2.97	1.69	1.67	1.73	0.421036977889306	1.96870870093976	0.0563322486471014	0.320104817683874	15:32593455-32607310:+	GOLGA8N	1;GO:0005794,cellular_component Golgi apparatus	NA	golgin A8 family member N [Source:HGNC Symbol%3BAcc:HGNC:44405]
ENSG00000093217	2.46	3.04	2.25	1.66	1.87	2.36	0.386190460482383	1.96575882681163	0.0563621732299555	0.320104817683874	3:38346759-38421348:+	XYLB	17;GO:0000166,molecular_function nucleotide binding;GO:0004856,molecular_function xylulokinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005997,biological_process xylulose metabolic process;GO:0005998,biological_process xylulose catabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019640,biological_process glucuronate catabolic process to xylulose 5-phosphate;GO:0042732,biological_process D-xylose metabolic process;GO:0046835,biological_process carbohydrate phosphorylation;GO:0070062,cellular_component extracellular exosome	xylB, XYLB; xylulokinase [EC:2.7.1.17]; K00854	xylulokinase [Source:HGNC Symbol%3BAcc:HGNC:12839]
ENSG00000102221	6.52	6.39	5.51	4.67	5.47	5.78	0.218824950245839	3.83425928328147	0.0563785780318979	0.320104817683874	X:46912275-47061242:+	JADE3	7;GO:0000123,cellular_component histone acetyltransferase complex;GO:0005515,molecular_function protein binding;GO:0043966,biological_process histone H3 acetylation;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043983,biological_process histone H4-K12 acetylation;GO:0046872,molecular_function metal ion binding	NA	jade family PHD finger 3 [Source:HGNC Symbol%3BAcc:HGNC:22982]
ENSG00000143753	134.96	131.64	141.39	128.45	118.91	129.96	0.125073689609179	7.01758273023332	0.0564130567953408	0.320104817683874	1:224175755-224193441:+	DEGS1	19;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0035579,cellular_component specific granule membrane;GO:0042284,molecular_function sphingolipid delta-4 desaturase activity;GO:0043312,biological_process neutrophil degranulation;GO:0046513,biological_process ceramide biosynthetic process;GO:0055114,biological_process oxidation-reduction process	DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]; K04712	delta 4-desaturase%2C sphingolipid 1 [Source:HGNC Symbol%3BAcc:HGNC:13709]
ENSG00000138316	1.06	0.65	0.74	0.55	0.62	0.63	0.473371894831866	1.47113611371187	0.0564238573344329	0.320104817683874	10:70672802-70762441:+	ADAMTS14	11;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0030199,biological_process collagen fibril organization;GO:0030574,biological_process collagen catabolic process;GO:0046872,molecular_function metal ion binding	NA	ADAM metallopeptidase with thrombospondin type 1 motif 14 [Source:HGNC Symbol%3BAcc:HGNC:14899]
ENSG00000164430	6.19	5.89	6.26	7.23	7.90	6.65	-0.230706050653468	3.4207740188355	0.0564850134753941	0.320305377921456	6:73413514-73452276:-	MB21D1	19;GO:0000166,molecular_function nucleotide binding;GO:0002218,biological_process activation of innate immune response;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032481,biological_process positive regulation of type I interferon production;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0061501,molecular_function cyclic-GMP-AMP synthase activity;GO:0071360,biological_process cellular response to exogenous dsRNA	NA	Mab-21 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21367]
ENSG00000144909	6.68	5.42	6.34	6.58	7.04	8.03	-0.212584226029125	3.92750765947508	0.0565503598801215	0.320529505567099	3:125528857-125595090:-	OSBPL11	10;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0010890,biological_process positive regulation of sequestering of triglyceride;GO:0016020,cellular_component membrane;GO:0031902,cellular_component late endosome membrane;GO:0045444,biological_process fat cell differentiation	NA	oxysterol binding protein like 11 [Source:HGNC Symbol%3BAcc:HGNC:16397]
ENSG00000165078	3.56	6.49	4.94	4.45	3.30	3.49	0.409882157653321	2.53227226363641	0.0566511185054119	0.320954054773016	8:67422037-67746385:-	CPA6	11;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	carboxypeptidase A6 [Source:HGNC Symbol%3BAcc:HGNC:17245]
ENSG00000011009	56.54	61.20	57.57	51.39	55.74	53.43	0.135447118340329	5.41855207265954	0.0566920212226222	0.321039260691793	1:23790969-23795539:+	LYPLA2	11;GO:0002084,biological_process protein depalmitoylation;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0007411,biological_process axon guidance;GO:0008474,molecular_function palmitoyl-(protein) hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0045296,molecular_function cadherin binding;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	lysophospholipase II [Source:HGNC Symbol%3BAcc:HGNC:6738]
ENSG00000100505	14.88	12.41	15.77	18.44	14.12	17.46	-0.200192493596126	5.30304566502742	0.0568009750565904	0.3215095774635	14:50975261-51096061:-	TRIM9	23;GO:0000149,molecular_function SNARE binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008021,cellular_component synaptic vesicle;GO:0008270,molecular_function zinc ion binding;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035544,biological_process negative regulation of SNARE complex assembly;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045202,cellular_component synapse;GO:0045955,biological_process negative regulation of calcium ion-dependent exocytosis;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 9 [Source:HGNC Symbol%3BAcc:HGNC:16288]
ENSG00000188493	15.29	16.75	17.84	18.57	19.24	18.80	-0.172321880042113	4.46902220597794	0.0568423800212713	0.321597294076591	19:40740855-40751553:-	C19orf54	NA	NA	chromosome 19 open reading frame 54 [Source:HGNC Symbol%3BAcc:HGNC:24758]
ENSG00000152137	24.87	28.49	23.93	22.91	23.46	22.23	0.176327967971498	4.43914909704343	0.0569049424861937	0.321733477438766	12:119178641-119221131:+	HSPB8	9;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0042802,molecular_function identical protein binding;GO:1900034,biological_process regulation of cellular response to heat	NA	heat shock protein family B (small) member 8 [Source:HGNC Symbol%3BAcc:HGNC:30171]
ENSG00000119782	6.88	4.02	3.75	6.79	7.05	6.85	-0.463633088952997	1.50927209142441	0.0569182886051342	0.321733477438766	2:24049700-24063681:+	FKBP1B	50;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0002027,biological_process regulation of heart rate;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005102,molecular_function receptor binding;GO:0005219,molecular_function ryanodine-sensitive calcium-release channel activity;GO:0005515,molecular_function protein binding;GO:0005528,molecular_function FK506 binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006458,biological_process 'de novo' protein folding;GO:0006939,biological_process smooth muscle contraction;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0009749,biological_process response to glucose;GO:0010033,biological_process response to organic substance;GO:0010459,biological_process negative regulation of heart rate;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014808,biological_process release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016853,molecular_function isomerase activity;GO:0019227,biological_process neuronal action potential propagation;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0022417,biological_process protein maturation by protein folding;GO:0030018,cellular_component Z disc;GO:0030073,biological_process insulin secretion;GO:0030551,molecular_function cyclic nucleotide binding;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0033197,biological_process response to vitamin E;GO:0034220,biological_process ion transmembrane transport;GO:0034704,cellular_component calcium channel complex;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0042026,biological_process protein refolding;GO:0042098,biological_process T cell proliferation;GO:0042542,biological_process response to hydrogen peroxide;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044325,molecular_function ion channel binding;GO:0048680,biological_process positive regulation of axon regeneration;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051280,biological_process negative regulation of release of sequestered calcium ion into cytosol;GO:0051284,biological_process positive regulation of sequestering of calcium ion;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0051775,biological_process response to redox state;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0060315,biological_process negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0061077,biological_process chaperone-mediated protein folding;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:1903779,biological_process regulation of cardiac conduction	NA	FK506 binding protein 1B [Source:HGNC Symbol%3BAcc:HGNC:3712]
ENSG00000177150	29.67	28.23	29.88	33.59	33.77	31.08	-0.149918868090981	4.83645262827234	0.0569605703965044	0.321800420917787	18:13663346-13726663:-	FAM210A	3;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 210 member A [Source:HGNC Symbol%3BAcc:HGNC:28346]
ENSG00000090020	7.72	7.35	8.61	7.27	6.82	7.02	0.182296533644941	4.30532069107621	0.0570007290205817	0.321800420917787	1:27098814-27166981:-	SLC9A1	85;GO:0002026,biological_process regulation of the force of heart contraction;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0006885,biological_process regulation of pH;GO:0009986,cellular_component cell surface;GO:0010447,biological_process response to acidic pH;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0010882,biological_process regulation of cardiac muscle contraction by calcium ion signaling;GO:0014070,biological_process response to organic cyclic compound;GO:0014704,cellular_component intercalated disc;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015386,molecular_function potassium:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0030011,biological_process maintenance of cell polarity;GO:0030027,cellular_component lamellipodium;GO:0030154,biological_process cell differentiation;GO:0030214,biological_process hyaluronan catabolic process;GO:0030307,biological_process positive regulation of cell growth;GO:0030315,cellular_component T-tubule;GO:0030346,molecular_function protein phosphatase 2B binding;GO:0030674,molecular_function protein binding, bridging;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032947,molecular_function protein complex scaffold;GO:0035725,biological_process sodium ion transmembrane transport;GO:0035794,biological_process positive regulation of mitochondrial membrane permeability;GO:0035994,biological_process response to muscle stretch;GO:0042383,cellular_component sarcolemma;GO:0042493,biological_process response to drug;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045121,cellular_component membrane raft;GO:0045760,biological_process positive regulation of action potential;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051259,biological_process protein oligomerization;GO:0051453,biological_process regulation of intracellular pH;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0051930,biological_process regulation of sensory perception of pain;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0070886,biological_process positive regulation of calcineurin-NFAT signaling cascade;GO:0070997,biological_process neuron death;GO:0071236,biological_process cellular response to antibiotic;GO:0071257,biological_process cellular response to electrical stimulus;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071436,biological_process sodium ion export;GO:0071456,biological_process cellular response to hypoxia;GO:0071468,biological_process cellular response to acidic pH;GO:0071805,biological_process potassium ion transmembrane transport;GO:0071872,biological_process cellular response to epinephrine stimulus;GO:0086003,biological_process cardiac muscle cell contraction;GO:0086036,biological_process regulation of cardiac muscle cell membrane potential;GO:0086040,molecular_function sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential;GO:0086092,biological_process regulation of the force of heart contraction by cardiac conduction;GO:0090533,cellular_component cation-transporting ATPase complex;GO:0098719,biological_process sodium ion import across plasma membrane;GO:0098735,biological_process positive regulation of the force of heart contraction;GO:1902533,biological_process positive regulation of intracellular signal transduction;GO:1902600,biological_process hydrogen ion transmembrane transport;GO:1903281,biological_process positive regulation of calcium:sodium antiporter activity	SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1; K05742	solute carrier family 9 member A1 [Source:HGNC Symbol%3BAcc:HGNC:11071]
ENSG00000172270	700.61	698.34	702.03	669.56	655.30	641.04	0.107604750812676	9.65348506164184	0.0570079050671243	0.321800420917787	19:571276-583493:+	BSG	31;GO:0000139,cellular_component Golgi membrane;GO:0002080,cellular_component acrosomal membrane;GO:0005515,molecular_function protein binding;GO:0005537,molecular_function mannose binding;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006090,biological_process pyruvate metabolic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007566,biological_process embryo implantation;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0030246,molecular_function carbohydrate binding;GO:0042383,cellular_component sarcolemma;GO:0042470,cellular_component melanosome;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043434,biological_process response to peptide hormone;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0046689,biological_process response to mercury ion;GO:0046697,biological_process decidualization;GO:0050900,biological_process leukocyte migration;GO:0051591,biological_process response to cAMP;GO:0070062,cellular_component extracellular exosome;GO:0072661,biological_process protein targeting to plasma membrane	NA	basigin (Ok blood group) [Source:HGNC Symbol%3BAcc:HGNC:1116]
ENSG00000184545	1.21	1.27	0.90	1.28	2.02	1.43	-0.47673475374445	1.42522391587133	0.0570933298183203	0.322136137743095	11:1554043-1571920:-	DUSP8	12;GO:0000188,biological_process inactivation of MAPK activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 8 [Source:HGNC Symbol%3BAcc:HGNC:3074]
ENSG00000176896	1.79	1.50	1.09	0.79	0.46	1.48	0.679741828375743	0.591948364976233	0.0571883771333121	0.322523656996895	X:13653188-13681964:+	TCEANC	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated	NA	transcription elongation factor A N-terminal and central domain containing [Source:HGNC Symbol%3BAcc:HGNC:28277]
ENSG00000164091	44.68	46.31	43.97	50.23	46.52	52.94	-0.140555048736934	5.48353210780797	0.0572350374496229	0.322523656996895	3:52254420-52288020:-	WDR82	13;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0016021,cellular_component integral component of membrane;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation;GO:0072357,cellular_component PTW/PP1 phosphatase complex;GO:0080182,biological_process histone H3-K4 trimethylation	WDR82, SWD2, CPS35; COMPASS component SWD2; K14962	WD repeat domain 82 [Source:HGNC Symbol%3BAcc:HGNC:28826]
ENSG00000146433	16.85	17.65	19.40	21.57	19.54	19.46	-0.155842957601288	5.13853670986988	0.0572804161441203	0.322523656996895	6:158536435-158635428:+	TMEM181	4;GO:0009405,biological_process pathogenesis;GO:0015643,molecular_function toxic substance binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 181 [Source:HGNC Symbol%3BAcc:HGNC:20958]
ENSG00000166484	5.88	6.88	6.01	5.48	5.70	5.20	0.199972653478993	3.86605975248317	0.0572906922400902	0.322523656996895	17:19377720-19383544:+	MAPK7	44;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019933,biological_process cAMP-mediated signaling;GO:0030154,biological_process cell differentiation;GO:0030821,biological_process negative regulation of cAMP catabolic process;GO:0034115,biological_process negative regulation of heterotypic cell-cell adhesion;GO:0036003,biological_process positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0045765,biological_process regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0051344,biological_process negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0051534,biological_process negative regulation of NFAT protein import into nucleus;GO:0060761,biological_process negative regulation of response to cytokine stimulus;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070377,biological_process negative regulation of ERK5 cascade;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071499,biological_process cellular response to laminar fluid shear stress;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]; K04464	mitogen-activated protein kinase 7 [Source:HGNC Symbol%3BAcc:HGNC:6880]
ENSG00000177302	10.55	10.14	10.35	11.38	10.96	12.21	-0.142334267732223	5.08847986591571	0.0572929223461087	0.322523656996895	17:18271427-18315007:-	TOP3A	18;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003916,molecular_function DNA topoisomerase activity;GO:0003917,molecular_function DNA topoisomerase type I activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006260,biological_process DNA replication;GO:0006265,biological_process DNA topological change;GO:0008270,molecular_function zinc ion binding;GO:0016605,cellular_component PML body;GO:0016853,molecular_function isomerase activity;GO:0046872,molecular_function metal ion binding;GO:0051321,biological_process meiotic cell cycle;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TOP3; DNA topoisomerase III [EC:5.6.2.1]; K03165	topoisomerase (DNA) III alpha [Source:HGNC Symbol%3BAcc:HGNC:11992]
ENSG00000215704	1.47	0.84	1.21	0.41	0.91	0.77	0.781255592375632	0.0187977452850892	0.0573179076238742	0.322523656996895	1:15465908-15491400:+	CELA2B	7;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity	CELA2; pancreatic elastase II [EC:3.4.21.71]; K01346	chymotrypsin like elastase family member 2B [Source:HGNC Symbol%3BAcc:HGNC:29995]
ENSG00000189298	4.42	5.62	5.43	6.12	6.67	5.79	-0.261191683371991	3.2178314413713	0.05737899614023	0.322721105160252	6:28349913-28369177:+	ZKSCAN3	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006914,biological_process autophagy;GO:0007040,biological_process lysosome organization;GO:0010507,biological_process negative regulation of autophagy;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:2000773,biological_process negative regulation of cellular senescence	NA	zinc finger with KRAB and SCAN domains 3 [Source:HGNC Symbol%3BAcc:HGNC:13853]
ENSG00000174516	5.02	6.24	5.46	4.79	5.09	3.91	0.280753072498843	3.00701445137209	0.0574511268669963	0.322980451902185	11:66466326-66477337:+	PELI3	12;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0008063,biological_process Toll signaling pathway;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	pellino E3 ubiquitin protein ligase family member 3 [Source:HGNC Symbol%3BAcc:HGNC:30010]
ENSG00000132000	2.30	1.33	2.47	1.39	0.78	2.00	0.567786219186106	1.81370124886439	0.0575151642177779	0.323133521713304	19:13931186-13953392:-	PODNL1	8;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0031012,cellular_component extracellular matrix;GO:0046426,biological_process negative regulation of JAK-STAT cascade	NA	podocan like 1 [Source:HGNC Symbol%3BAcc:HGNC:26275]
ENSG00000150667	0.69	1.04	0.59	0.52	0.48	0.40	0.705074440463725	0.268549934769635	0.0575304183506325	0.323133521713304	15:39600030-39782830:-	FSIP1	NA	NA	fibrous sheath interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21674]
ENSG00000221923	0.51	0.44	0.45	0.84	0.50	0.86	-0.642662181181229	0.424361525646668	0.0575831361328568	0.32328334184403	19:52369916-52385795:+	ZNF880	5;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 880 [Source:HGNC Symbol%3BAcc:HGNC:37249]
ENSG00000156042	1.82	1.13	1.00	0.96	0.52	1.23	0.564251634332935	1.97181079658965	0.0576571282584313	0.323552410972834	10:73253758-73358859:-	CFAP70	5;GO:0003674,molecular_function molecular_function;GO:0005929,cellular_component cilium;GO:0008150,biological_process biological_process;GO:0042995,cellular_component cell projection;GO:0070062,cellular_component extracellular exosome	NA	cilia and flagella associated protein 70 [Source:HGNC Symbol%3BAcc:HGNC:30726]
ENSG00000096717	10.03	9.67	10.36	10.67	11.24	12.00	-0.160483993888609	4.61196816414041	0.0577525878695823	0.323941650802135	10:67884668-67918390:+	SIRT1	166;GO:0000012,biological_process single strand break repair;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000720,biological_process pyrimidine dimer repair by nucleotide-excision repair;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0001542,biological_process ovulation from ovarian follicle;GO:0001678,biological_process cellular glucose homeostasis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002039,molecular_function p53 binding;GO:0002821,biological_process positive regulation of adaptive immune response;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005654,cellular_component nucleoplasm;GO:0005677,cellular_component chromatin silencing complex;GO:0005719,cellular_component nuclear euchromatin;GO:0005720,cellular_component nuclear heterochromatin;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006325,biological_process chromatin organization;GO:0006342,biological_process chromatin silencing;GO:0006343,biological_process establishment of chromatin silencing;GO:0006344,biological_process maintenance of chromatin silencing;GO:0006346,biological_process methylation-dependent chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006476,biological_process protein deacetylation;GO:0006642,biological_process triglyceride mobilization;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007517,biological_process muscle organ development;GO:0007569,biological_process cell aging;GO:0007623,biological_process circadian rhythm;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009267,biological_process cellular response to starvation;GO:0010629,biological_process negative regulation of gene expression;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0010883,biological_process regulation of lipid storage;GO:0010906,biological_process regulation of glucose metabolic process;GO:0010934,biological_process macrophage cytokine production;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016032,biological_process viral process;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016575,biological_process histone deacetylation;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0017136,molecular_function NAD-dependent histone deacetylase activity;GO:0018394,biological_process peptidyl-lysine acetylation;GO:0019213,molecular_function deacetylase activity;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation;GO:0030225,biological_process macrophage differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031393,biological_process negative regulation of prostaglandin biosynthetic process;GO:0031648,biological_process protein destabilization;GO:0031937,biological_process positive regulation of chromatin silencing;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032071,biological_process regulation of endodeoxyribonuclease activity;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032868,biological_process response to insulin;GO:0032922,biological_process circadian regulation of gene expression;GO:0033158,biological_process regulation of protein import into nucleus, translocation;GO:0033210,biological_process leptin-mediated signaling pathway;GO:0033553,cellular_component rDNA heterochromatin;GO:0033558,molecular_function protein deacetylase activity;GO:0034391,biological_process regulation of smooth muscle cell apoptotic process;GO:0034979,molecular_function NAD-dependent protein deacetylase activity;GO:0034983,biological_process peptidyl-lysine deacetylation;GO:0035098,cellular_component ESC/E(Z) complex;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035356,biological_process cellular triglyceride homeostasis;GO:0035358,biological_process regulation of peroxisome proliferator activated receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042326,biological_process negative regulation of phosphorylation;GO:0042393,molecular_function histone binding;GO:0042542,biological_process response to hydrogen peroxide;GO:0042595,biological_process behavioral response to starvation;GO:0042632,biological_process cholesterol homeostasis;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043398,molecular_function HLH domain binding;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044321,biological_process response to leptin;GO:0045348,biological_process positive regulation of MHC class II biosynthetic process;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045739,biological_process positive regulation of DNA repair;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0046969,molecular_function NAD-dependent histone deacetylase activity (H3-K9 specific);GO:0048511,biological_process rhythmic process;GO:0050872,biological_process white fat cell differentiation;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051097,biological_process negative regulation of helicase activity;GO:0051152,biological_process positive regulation of smooth muscle cell differentiation;GO:0051574,biological_process positive regulation of histone H3-K9 methylation;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0055089,biological_process fatty acid homeostasis;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0061647,biological_process histone H3-K9 modification;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070403,molecular_function NAD+ binding;GO:0070857,biological_process regulation of bile acid biosynthetic process;GO:0070914,biological_process UV-damage excision repair;GO:0070932,biological_process histone H3 deacetylation;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071441,biological_process negative regulation of histone H3-K14 acetylation;GO:0071456,biological_process cellular response to hypoxia;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071900,biological_process regulation of protein serine/threonine kinase activity;GO:0090335,biological_process regulation of brown fat cell differentiation;GO:0090400,biological_process stress-induced premature senescence;GO:1900034,biological_process regulation of cellular response to heat;GO:1900113,biological_process negative regulation of histone H3-K9 trimethylation;GO:1901215,biological_process negative regulation of neuron death;GO:1901984,biological_process negative regulation of protein acetylation;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1904179,biological_process positive regulation of adipose tissue development;GO:1990254,molecular_function keratin filament binding;GO:1990619,biological_process histone H3-K9 deacetylation;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000111,biological_process positive regulation of macrophage apoptotic process;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity;GO:2000481,biological_process positive regulation of cAMP-dependent protein kinase activity;GO:2000619,biological_process negative regulation of histone H4-K16 acetylation;GO:2000655,biological_process negative regulation of cellular response to testosterone stimulus;GO:2000757,biological_process negative regulation of peptidyl-lysine acetylation;GO:2000773,biological_process negative regulation of cellular senescence;GO:2000774,biological_process positive regulation of cellular senescence	SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]; K11411	sirtuin 1 [Source:HGNC Symbol%3BAcc:HGNC:14929]
ENSG00000165171	9.13	10.79	9.11	13.04	10.22	12.05	-0.281917908848107	3.00578958899337	0.0578518219121208	0.324336460093632	7:73834589-73842535:-	METTL27	1;GO:0005515,molecular_function protein binding	NA	methyltransferase like 27 [Source:HGNC Symbol%3BAcc:HGNC:19068]
ENSG00000167904	32.28	31.48	32.91	36.34	34.05	36.76	-0.13580761807836	5.22676369841747	0.0578752323457179	0.324336460093632	8:55696423-55773407:-	TMEM68	4;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016746,molecular_function transferase activity, transferring acyl groups	NA	transmembrane protein 68 [Source:HGNC Symbol%3BAcc:HGNC:26510]
ENSG00000116213	12.41	11.31	11.72	10.57	10.55	10.51	0.180162489239687	4.02821238804753	0.0579534189827082	0.32442497193293	1:3630766-3652761:-	WRAP73	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0090307,biological_process mitotic spindle assembly;GO:1902857,biological_process positive regulation of nonmotile primary cilium assembly	NA	WD repeat containing%2C antisense to TP73 [Source:HGNC Symbol%3BAcc:HGNC:12759]
ENSG00000183850	0.69	0.82	0.99	1.46	1.16	1.07	-0.54958325577903	0.886786089885747	0.057959092980682	0.32442497193293	19:23075209-23147219:+	ZNF730	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 730 [Source:HGNC Symbol%3BAcc:HGNC:32470]
ENSG00000120708	1117.42	914.99	1139.60	1283.80	1057.41	1268.80	-0.17486178548627	11.2190769331956	0.0579694342823845	0.32442497193293	5:136028894-136063818:+	TGFBI	21;GO:0001525,biological_process angiogenesis;GO:0002062,biological_process chondrocyte differentiation;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007601,biological_process visual perception;GO:0008283,biological_process cell proliferation;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0044267,biological_process cellular protein metabolic process;GO:0050840,molecular_function extracellular matrix binding;GO:0050896,biological_process response to stimulus;GO:0070062,cellular_component extracellular exosome	NA	transforming growth factor beta induced [Source:HGNC Symbol%3BAcc:HGNC:11771]
ENSG00000120549	14.61	16.35	16.06	13.88	15.20	14.07	0.134368119420607	6.52945841115995	0.0580906357831081	0.324956765198613	10:23694745-24547848:+	KIAA1217	7;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0030334,biological_process regulation of cell migration;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0048706,biological_process embryonic skeletal system development;GO:0061001,biological_process regulation of dendritic spine morphogenesis	NA	KIAA1217 [Source:HGNC Symbol%3BAcc:HGNC:25428]
ENSG00000157637	44.56	43.83	40.55	37.32	42.05	39.39	0.130047459952208	7.24257914921636	0.0581805822392497	0.325183377697153	17:81244999-81295547:-	SLC38A10	10;GO:0003333,biological_process amino acid transmembrane transport;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0060348,biological_process bone development	NA	solute carrier family 38 member 10 [Source:HGNC Symbol%3BAcc:HGNC:28237]
ENSG00000148773	25.25	28.25	24.59	27.47	32.52	27.55	-0.153827649983047	8.07610020486726	0.0581835399875435	0.325183377697153	10:128096658-128126385:-	MKI67	25;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000793,cellular_component condensed chromosome;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006259,biological_process DNA metabolic process;GO:0007049,biological_process cell cycle;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0030212,biological_process hyaluronan metabolic process;GO:0031100,biological_process organ regeneration;GO:0034605,biological_process cellular response to heat;GO:0051321,biological_process meiotic cell cycle;GO:0051983,biological_process regulation of chromosome segregation;GO:1902275,biological_process regulation of chromatin organization	NA	marker of proliferation Ki-67 [Source:HGNC Symbol%3BAcc:HGNC:7107]
ENSG00000168386	4.61	6.18	5.30	5.25	8.32	6.20	-0.28975589296561	4.47745386600335	0.0582223755058366	0.325253981617439	3:99830140-100114513:-	FILIP1L	5;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane	NA	filamin A interacting protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:24589]
ENSG00000116731	5.93	5.54	6.13	4.64	5.47	5.68	0.17064373329637	4.86759018833694	0.0582611405363312	0.325324128419919	1:13700197-13825079:+	PRDM2	19;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0008340,biological_process determination of adult lifespan;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	PRDM2, RIZ; [histone H3]-lysine9 N-trimethyltransferase PRDM2 [EC:2.1.1.355]; K11432	PR/SET domain 2 [Source:HGNC Symbol%3BAcc:HGNC:9347]
ENSG00000156398	5.52	4.33	3.76	3.39	3.73	3.53	0.371659877651408	2.1193693734674	0.0583168163370919	0.325488597658418	10:102714537-102743492:+	SFXN2	11;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0034220,biological_process ion transmembrane transport;GO:0055072,biological_process iron ion homeostasis;GO:0055085,biological_process transmembrane transport	NA	sideroflexin 2 [Source:HGNC Symbol%3BAcc:HGNC:16086]
ENSG00000096401	34.49	32.97	33.50	36.13	36.06	38.55	-0.121107316581864	6.41175593455581	0.0583904586236529	0.325753151863103	6:44387524-44450426:+	CDC5L	44;GO:0000278,biological_process mitotic cell cycle;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001135,molecular_function transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0001222,molecular_function transcription corepressor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0019901,molecular_function protein kinase binding;GO:0030154,biological_process cell differentiation;GO:0032993,cellular_component protein-DNA complex;GO:0043522,molecular_function leucine zipper domain binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071352,biological_process cellular response to interleukin-2;GO:0071987,molecular_function WD40-repeat domain binding;GO:0072422,biological_process signal transduction involved in DNA damage checkpoint;GO:1904568,biological_process cellular response to wortmannin;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990646,biological_process cellular response to prolactin	CDC5L, CDC5, CEF1; pre-mRNA-splicing factor CDC5/CEF1; K12860	cell division cycle 5 like [Source:HGNC Symbol%3BAcc:HGNC:1743]
ENSG00000167702	28.71	27.37	30.48	24.33	25.88	28.89	0.142673881149498	6.12183939162773	0.0585148151481258	0.326300269736606	8:144466042-144474202:+	KIFC2	10;GO:0000166,molecular_function nucleotide binding;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity	NA	kinesin family member C2 [Source:HGNC Symbol%3BAcc:HGNC:29530]
ENSG00000197594	7.56	7.61	7.64	6.26	7.38	6.72	0.176201235799599	4.32911428559302	0.0586133705897022	0.326703084476863	6:131808015-131895155:+	ENPP1	48;GO:0003676,molecular_function nucleic acid binding;GO:0003824,molecular_function catalytic activity;GO:0004528,molecular_function phosphodiesterase I activity;GO:0004551,molecular_function nucleotide diphosphatase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006771,biological_process riboflavin metabolic process;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006955,biological_process immune response;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009143,biological_process nucleoside triphosphate catabolic process;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0030247,molecular_function polysaccharide binding;GO:0030308,biological_process negative regulation of cell growth;GO:0030500,biological_process regulation of bone mineralization;GO:0030505,biological_process inorganic diphosphate transport;GO:0030643,biological_process cellular phosphate ion homeostasis;GO:0030730,biological_process sequestering of triglyceride;GO:0031214,biological_process biomineral tissue development;GO:0031953,biological_process negative regulation of protein autophosphorylation;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035529,molecular_function NADH pyrophosphatase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045719,biological_process negative regulation of glycogen biosynthetic process;GO:0046034,biological_process ATP metabolic process;GO:0046325,biological_process negative regulation of glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0047429,molecular_function nucleoside-triphosphate diphosphatase activity;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0050656,molecular_function 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]; K01513	ectonucleotide pyrophosphatase/phosphodiesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:3356]
ENSG00000155893	0.27	0.90	0.78	0.28	0.48	0.31	0.834155373893732	-0.111441225679291	0.0587065901429719	0.327075809445561	3:141228725-141367753:+	PXYLP1	12;GO:0000139,cellular_component Golgi membrane;GO:0003993,molecular_function acid phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0010909,biological_process positive regulation of heparan sulfate proteoglycan biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0050650,biological_process chondroitin sulfate proteoglycan biosynthetic process	NA	2-phosphoxylose phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:26303]
ENSG00000171469	12.15	12.21	12.19	11.49	9.83	11.19	0.178942242692514	4.17601854779197	0.0587779954251725	0.327326719251981	19:9604679-9621399:-	ZNF561	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 561 [Source:HGNC Symbol%3BAcc:HGNC:28684]
ENSG00000182472	4.84	3.89	4.24	3.56	3.15	4.15	0.273090437250244	3.14907380594804	0.0589108680121465	0.327919553647881	19:38730186-38769904:-	CAPN12	9;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	calpain 12 [Source:HGNC Symbol%3BAcc:HGNC:13249]
ENSG00000197977	3.66	4.95	4.72	5.48	7.77	4.67	-0.420440176196007	2.25281534584537	0.0589695402912262	0.328099015524425	6:10980758-11044314:-	ELOVL2	25;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0009922,molecular_function fatty acid elongase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0019367,biological_process fatty acid elongation, saturated fatty acid;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034625,biological_process fatty acid elongation, monounsaturated fatty acid;GO:0034626,biological_process fatty acid elongation, polyunsaturated fatty acid;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0043651,biological_process linoleic acid metabolic process;GO:0102336,molecular_function 3-oxo-arachidoyl-CoA synthase activity;GO:0102337,molecular_function 3-oxo-cerotoyl-CoA synthase activity;GO:0102338,molecular_function 3-oxo-lignoceronyl-CoA synthase activity	ELOVL2; elongation of very long chain fatty acids protein 2 [EC:2.3.1.199]; K10205	ELOVL fatty acid elongase 2 [Source:HGNC Symbol%3BAcc:HGNC:14416]
ENSG00000146555	9.01	8.42	8.35	9.51	9.93	9.00	-0.128641148645831	5.9195392623608	0.0590250122523072	0.328260518408552	7:3301447-4269000:+	SDK1	14;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416,biological_process synapse assembly;GO:0010842,biological_process retina layer formation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0042802,molecular_function identical protein binding;GO:0045202,cellular_component synapse;GO:0045216,biological_process cell-cell junction organization;GO:0048148,biological_process behavioral response to cocaine;GO:0060998,biological_process regulation of dendritic spine development;GO:0070062,cellular_component extracellular exosome	NA	sidekick cell adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:19307]
ENSG00000166398	5.90	6.13	6.95	7.23	7.30	7.05	-0.172226133740427	4.4524659757243	0.0591281465039248	0.328604689851338	19:34254536-34355586:+	KIAA0355	NA	NA	KIAA0355 [Source:HGNC Symbol%3BAcc:HGNC:29016]
ENSG00000100258	43.13	40.99	38.38	38.80	38.63	34.96	0.136518058660319	6.39160964741827	0.0591398434808578	0.328604689851338	22:50502948-50507691:-	LMF2	6;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051604,biological_process protein maturation	NA	lipase maturation factor 2 [Source:HGNC Symbol%3BAcc:HGNC:25096]
ENSG00000150457	4.46	3.98	4.06	3.37	3.86	3.71	0.208930145418226	3.69018448723703	0.0591937462216393	0.328757034384433	13:20973031-21061547:-	LATS2	27;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000922,cellular_component spindle pole;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035329,biological_process hippo signaling;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0046620,biological_process regulation of organ growth;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	LATS1_2, Wts; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]; K08791	large tumor suppressor kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6515]
ENSG00000138801	24.71	26.55	23.94	26.52	29.37	27.42	-0.139059765287733	5.63269204053591	0.0592387564313351	0.328859876378427	4:107590275-107720452:-	PAPSS1	15;GO:0000103,biological_process sulfate assimilation;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0003824,molecular_function catalytic activity;GO:0004020,molecular_function adenylylsulfate kinase activity;GO:0004781,molecular_function sulfate adenylyltransferase (ATP) activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0050428,biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	NA	3'-phosphoadenosine 5'-phosphosulfate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:8603]
ENSG00000275074	4.27	2.12	3.56	1.58	2.91	2.55	0.532445462737553	1.58418975542022	0.0592920575046643	0.328988664677023	8:22106871-22109419:-	NUDT18	13;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0009117,biological_process nucleotide metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0044715,molecular_function 8-oxo-dGDP phosphatase activity;GO:0044716,molecular_function 8-oxo-GDP phosphatase activity;GO:0044717,molecular_function 8-hydroxy-dADP phosphatase activity;GO:0046057,biological_process dADP catabolic process;GO:0046067,biological_process dGDP catabolic process;GO:0046712,biological_process GDP catabolic process;GO:0046872,molecular_function metal ion binding	NA	nudix hydrolase 18 [Source:HGNC Symbol%3BAcc:HGNC:26194]
ENSG00000104497	15.88	20.28	17.12	16.32	15.58	14.38	0.205697281983192	4.10277980839797	0.059314962663915	0.328988664677023	8:81799580-81842866:-	SNX16	19;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006622,biological_process protein targeting to lysosome;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0031313,cellular_component extrinsic component of endosome membrane;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045022,biological_process early endosome to late endosome transport	NA	sorting nexin 16 [Source:HGNC Symbol%3BAcc:HGNC:14980]
ENSG00000151690	6.16	5.50	5.49	6.46	6.39	6.92	-0.190237783192809	3.90302652395209	0.0594031308404741	0.329330532882003	2:190408354-190509205:+	MFSD6	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	major facilitator superfamily domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:24711]
ENSG00000169100	370.67	383.87	379.12	415.31	413.40	403.82	-0.109091196534861	8.46319826122007	0.0594665427151104	0.329462930920885	X:1386151-1392724:-	SLC25A6	22;GO:0005215,molecular_function transporter activity;GO:0005471,molecular_function ATP:ADP antiporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0015207,molecular_function adenine transmembrane transporter activity;GO:0015853,biological_process adenine transport;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0031012,cellular_component extracellular matrix;GO:0046732,biological_process active induction of host immune response by virus;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0050796,biological_process regulation of insulin secretion;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 6 [Source:HGNC Symbol%3BAcc:HGNC:10992]
ENSG00000153147	68.39	67.25	66.74	71.60	74.66	74.06	-0.110676368117944	7.79861389406532	0.0594964256220919	0.329462930920885	4:143513462-143557486:+	SMARCA5	27;GO:0000166,molecular_function nucleotide binding;GO:0000793,cellular_component condensed chromosome;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006338,biological_process chromatin remodeling;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016569,biological_process covalent chromatin modification;GO:0016584,biological_process nucleosome positioning;GO:0016589,cellular_component NURF complex;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0016887,molecular_function ATPase activity;GO:0031213,cellular_component RSF complex;GO:0031491,molecular_function nucleosome binding;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0042393,molecular_function histone binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043596,cellular_component nuclear replication fork;GO:0045815,biological_process positive regulation of gene expression, epigenetic	NA	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 5 [Source:HGNC Symbol%3BAcc:HGNC:11101]
ENSG00000135837	5.20	5.28	5.71	4.77	5.07	5.06	0.132281464868251	5.64140676373083	0.0595251827998483	0.329462930920885	1:179954737-180114880:+	CEP350	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0034453,biological_process microtubule anchoring	NA	centrosomal protein 350 [Source:HGNC Symbol%3BAcc:HGNC:24238]
ENSG00000166128	12.42	14.82	11.52	10.47	11.66	10.32	0.256558503485018	3.11441229911679	0.0595331792520378	0.329462930920885	15:63189468-63267782:+	RAB8B	36;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005778,cellular_component peroxisomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0009306,biological_process protein secretion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0017157,biological_process regulation of exocytosis;GO:0019003,molecular_function GDP binding;GO:0019882,biological_process antigen processing and presentation;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030911,molecular_function TPR domain binding;GO:0031346,biological_process positive regulation of cell projection organization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034332,biological_process adherens junction organization;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045046,biological_process protein import into peroxisome membrane;GO:0045335,cellular_component phagocytic vesicle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051286,cellular_component cell tip;GO:0051461,biological_process positive regulation of corticotropin secretion;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane	RAB8B; Ras-related protein Rab-8B; K07902	RAB8B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:30273]
ENSG00000115275	40.61	39.73	41.36	37.00	37.42	38.65	0.118431944722175	6.62164604241331	0.0596423508295112	0.329920009289983	2:74461056-74465410:-	MOGS	14;GO:0003824,molecular_function catalytic activity;GO:0004573,molecular_function mannosyl-oligosaccharide glucosidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0006487,biological_process protein N-linked glycosylation;GO:0008152,biological_process metabolic process;GO:0009311,biological_process oligosaccharide metabolic process;GO:0015926,molecular_function glucosidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0070062,cellular_component extracellular exosome	MOGS; mannosyl-oligosaccharide glucosidase [EC:3.2.1.106]; K01228	mannosyl-oligosaccharide glucosidase [Source:HGNC Symbol%3BAcc:HGNC:24862]
ENSG00000109572	16.25	18.69	16.33	18.33	20.91	18.22	-0.156406753287205	5.6615037503366	0.0597892428590336	0.330585243478478	4:169612632-169723673:+	CLCN3	42;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0005216,molecular_function ion channel activity;GO:0005247,molecular_function voltage-gated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0006885,biological_process regulation of pH;GO:0008021,cellular_component synaptic vesicle;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0012506,cellular_component vesicle membrane;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030141,cellular_component secretory granule;GO:0030165,molecular_function PDZ domain binding;GO:0030658,cellular_component transport vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0034220,biological_process ion transmembrane transport;GO:0042581,cellular_component specific granule;GO:0042803,molecular_function protein homodimerization activity;GO:0044070,biological_process regulation of anion transport;GO:0045335,cellular_component phagocytic vesicle;GO:0045794,biological_process negative regulation of cell volume;GO:0046982,molecular_function protein heterodimerization activity;GO:0048388,biological_process endosomal lumen acidification;GO:0055085,biological_process transmembrane transport;GO:0072320,molecular_function volume-sensitive chloride channel activity;GO:1902476,biological_process chloride transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport	NA	chloride voltage-gated channel 3 [Source:HGNC Symbol%3BAcc:HGNC:2021]
ENSG00000102575	7.17	7.45	6.42	7.45	10.35	8.22	-0.297511897399034	2.96399725219105	0.0598380837047701	0.330707984428901	19:11574659-11579008:-	ACP5	22;GO:0003993,molecular_function acid phosphatase activity;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006771,biological_process riboflavin metabolic process;GO:0008198,molecular_function ferrous iron binding;GO:0008199,molecular_function ferric iron binding;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0032691,biological_process negative regulation of interleukin-1 beta production;GO:0032695,biological_process negative regulation of interleukin-12 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032929,biological_process negative regulation of superoxide anion generation;GO:0034097,biological_process response to cytokine;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0045453,biological_process bone resorption;GO:0046872,molecular_function metal ion binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0060349,biological_process bone morphogenesis;GO:0070062,cellular_component extracellular exosome	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]; K14379	acid phosphatase 5%2C tartrate resistant [Source:HGNC Symbol%3BAcc:HGNC:124]
ENSG00000102174	1.67	2.25	2.33	2.20	2.60	3.32	-0.376563265617347	2.47117094864231	0.0598956130119931	0.33073243048575	X:22032440-22251310:+	PHEX	29;GO:0001501,biological_process skeletal system development;GO:0004177,molecular_function aminopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0007267,biological_process cell-cell signaling;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019637,biological_process organophosphate metabolic process;GO:0030282,biological_process bone mineralization;GO:0030324,biological_process lung development;GO:0031214,biological_process biomineral tissue development;GO:0033280,biological_process response to vitamin D;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060348,biological_process bone development;GO:0060416,biological_process response to growth hormone;GO:0071305,biological_process cellular response to vitamin D;GO:0071374,biological_process cellular response to parathyroid hormone stimulus;GO:1904383,biological_process response to sodium phosphate;GO:1990418,biological_process response to insulin-like growth factor stimulus	NA	phosphate regulating endopeptidase homolog X-linked [Source:HGNC Symbol%3BAcc:HGNC:8918]
ENSG00000140025	11.82	14.67	8.69	12.53	16.42	16.20	-0.36373610476057	2.79355081131548	0.0599091632802557	0.33073243048575	14:89794668-89954777:-	EFCAB11	2;GO:0005509,molecular_function calcium ion binding;GO:0046872,molecular_function metal ion binding	NA	EF-hand calcium binding domain 11 [Source:HGNC Symbol%3BAcc:HGNC:20357]
ENSG00000089248	163.03	166.12	162.51	150.36	156.38	150.99	0.114620326682051	7.08380155883657	0.0599224390689159	0.33073243048575	12:112013315-112023451:+	ERP29	20;GO:0000187,biological_process activation of MAPK activity;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0006457,biological_process protein folding;GO:0006886,biological_process intracellular protein transport;GO:0009306,biological_process protein secretion;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0030133,cellular_component transport vesicle;GO:0042470,cellular_component melanosome;GO:0042803,molecular_function protein homodimerization activity;GO:0043335,biological_process protein unfolding;GO:0050709,biological_process negative regulation of protein secretion;GO:0051087,molecular_function chaperone binding;GO:0070062,cellular_component extracellular exosome;GO:1902235,biological_process regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ERP29; endoplasmic reticulum protein 29; K09586	endoplasmic reticulum protein 29 [Source:HGNC Symbol%3BAcc:HGNC:13799]
ENSG00000100711	36.80	37.52	40.21	34.68	34.65	35.60	0.138443306218859	5.12553519771656	0.0600527231878297	0.331196906385231	14:103715729-103733668:+	ZFYVE21	11;GO:0000285,molecular_function 1-phosphatidylinositol-3-phosphate 5-kinase activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0010008,cellular_component endosome membrane;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046872,molecular_function metal ion binding	NA	zinc finger FYVE-type containing 21 [Source:HGNC Symbol%3BAcc:HGNC:20760]
ENSG00000240038	1.38	1.06	1.82	1.22	0.94	0.83	0.5487570718556	1.00987514639094	0.0600599561969834	0.331196906385231	1:103553814-103579534:+	AMY2B	11;GO:0003824,molecular_function catalytic activity;GO:0004556,molecular_function alpha-amylase activity;GO:0005576,cellular_component extracellular region;GO:0005975,biological_process carbohydrate metabolic process;GO:0007586,biological_process digestion;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	AMY, amyA, malS; alpha-amylase [EC:3.2.1.1]; K01176	amylase%2C alpha 2B (pancreatic) [Source:HGNC Symbol%3BAcc:HGNC:478]
ENSG00000213903	7.56	6.97	9.69	9.22	9.19	11.39	-0.280913963642669	3.28237515863145	0.0602253973868281	0.331961748562477	14:24311449-24318036:+	LTB4R	20;GO:0000166,molecular_function nucleotide binding;GO:0001632,molecular_function leukotriene B4 receptor activity;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004974,molecular_function leukotriene receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0006936,biological_process muscle contraction;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0008528,molecular_function G-protein coupled peptide receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045121,cellular_component membrane raft;GO:0061737,biological_process leukotriene signaling pathway	LTB4R1; leukotriene B4 receptor 1; K04296	leukotriene B4 receptor [Source:HGNC Symbol%3BAcc:HGNC:6713]
ENSG00000150967	2.43	2.33	2.35	1.98	2.04	1.83	0.293524840361852	2.42255767972267	0.0602647269846417	0.332031094567402	12:122920950-122981649:-	ABCB9	20;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0015421,molecular_function oligopeptide-transporting ATPase activity;GO:0015440,molecular_function peptide-transporting ATPase activity;GO:0015833,biological_process peptide transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0035672,biological_process oligopeptide transmembrane transport;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055085,biological_process transmembrane transport	ABCB9, TAPL; ATP-binding cassette, subfamily B (MDR/TAP), member 9; K05656	ATP binding cassette subfamily B member 9 [Source:HGNC Symbol%3BAcc:HGNC:50]
ENSG00000167721	45.47	40.74	42.10	47.31	46.23	47.39	-0.12197156828316	6.76841431778819	0.0604005033929772	0.332548710595417	17:2322502-2337507:-	TSR1	14;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479,biological_process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0030688,cellular_component preribosome, small subunit precursor;GO:0034511,molecular_function U3 snoRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0042255,biological_process ribosome assembly	NA	TSR1%2C ribosome maturation factor [Source:HGNC Symbol%3BAcc:HGNC:25542]
ENSG00000008018	214.03	225.63	213.07	232.69	245.36	235.37	-0.117336857002161	7.36503036733978	0.0604348072303186	0.332548710595417	6:170535116-170553341:-	PSMB1	44;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMB1; 20S proteasome subunit beta 6 [EC:3.4.25.1]; K02732	proteasome subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:9537]
ENSG00000154845	30.01	33.16	28.49	33.20	35.78	32.67	-0.13976559340222	6.62994784112492	0.0604390470557689	0.332548710595417	18:9546790-9615240:-	PPP4R1	8;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0006468,biological_process protein phosphorylation;GO:0006470,biological_process protein dephosphorylation;GO:0007165,biological_process signal transduction;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030289,cellular_component protein phosphatase 4 complex;GO:0050790,biological_process regulation of catalytic activity	NA	protein phosphatase 4 regulatory subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:9320]
ENSG00000140836	4.49	3.96	4.62	4.86	4.63	5.07	-0.138935339639336	5.68502801755632	0.0606399968266892	0.333506548785863	16:72782884-73144447:-	ZFHX3	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007050,biological_process cell cycle arrest;GO:0007420,biological_process brain development;GO:0007517,biological_process muscle organ development;GO:0008270,molecular_function zinc ion binding;GO:0016604,cellular_component nuclear body;GO:0019899,molecular_function enzyme binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045664,biological_process regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0071559,biological_process response to transforming growth factor beta;GO:1904059,biological_process regulation of locomotor rhythm	ATBF1; AT-binding transcription factor 1; K09378	zinc finger homeobox 3 [Source:HGNC Symbol%3BAcc:HGNC:777]
ENSG00000178301	0.96	2.70	1.99	1.20	1.31	0.86	0.716748333507645	0.413746499958446	0.0606996746179821	0.333651208189241	11:77589390-77610355:+	AQP11	15;GO:0001822,biological_process kidney development;GO:0003674,molecular_function molecular_function;GO:0005215,molecular_function transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0048388,biological_process endosomal lumen acidification;GO:0051260,biological_process protein homooligomerization;GO:0072014,biological_process proximal tubule development	NA	aquaporin 11 [Source:HGNC Symbol%3BAcc:HGNC:19940]
ENSG00000241878	35.41	34.96	36.14	41.73	37.71	38.08	-0.129270783705791	5.76042702047189	0.0607200579472726	0.333651208189241	22:31618490-31662432:-	PISD	13;GO:0004609,molecular_function phosphatidylserine decarboxylase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016540,biological_process protein autoprocessing;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0031305,cellular_component integral component of mitochondrial inner membrane	psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]; K01613	phosphatidylserine decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:8999]
ENSG00000159733	1.68	1.87	2.26	1.49	1.35	1.77	0.342034351446061	2.35585591816215	0.0607926278484092	0.333793432496894	4:2269581-2418663:-	ZFYVE28	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0016020,cellular_component membrane;GO:0031901,cellular_component early endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0046872,molecular_function metal ion binding	NA	zinc finger FYVE-type containing 28 [Source:HGNC Symbol%3BAcc:HGNC:29334]
ENSG00000165105	9.77	9.05	10.06	10.71	10.14	11.88	-0.165982107621731	4.61013614450011	0.0608218927033168	0.333793432496894	9:82979584-83063177:-	RASEF	7;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005509,molecular_function calcium ion binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	RAS and EF-hand domain containing [Source:HGNC Symbol%3BAcc:HGNC:26464]
ENSG00000116117	1.21	1.39	0.94	1.42	2.05	1.26	-0.414262505535675	2.44323647144205	0.0608510548177265	0.333793432496894	2:204545792-205620162:+	PARD3B	8;GO:0005515,molecular_function protein binding;GO:0005923,cellular_component bicellular tight junction;GO:0007049,biological_process cell cycle;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0043234,cellular_component protein complex;GO:0051301,biological_process cell division	NA	par-3 family cell polarity regulator beta [Source:HGNC Symbol%3BAcc:HGNC:14446]
ENSG00000106714	1.96	1.96	2.02	1.85	1.66	1.50	0.263824003645787	2.85583375307452	0.060853503402922	0.333793432496894	9:39072766-39288315:-	CNTNAP3	6;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0008037,biological_process cell recognition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	contactin associated protein like 3 [Source:HGNC Symbol%3BAcc:HGNC:13834]
ENSG00000078070	23.38	25.11	23.55	25.99	25.86	27.21	-0.125689594622672	5.82113560413586	0.0611342623507595	0.335185335052993	3:183015217-183116075:-	MCCC1	19;GO:0000166,molecular_function nucleotide binding;GO:0002169,cellular_component 3-methylcrotonyl-CoA carboxylase complex, mitochondrial;GO:0003824,molecular_function catalytic activity;GO:0004075,molecular_function biotin carboxylase activity;GO:0004485,molecular_function methylcrotonoyl-CoA carboxylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006552,biological_process leucine catabolic process;GO:0006768,biological_process biotin metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0009374,molecular_function biotin binding;GO:0016874,molecular_function ligase activity;GO:0046872,molecular_function metal ion binding;GO:0051291,biological_process protein heterooligomerization;GO:1905202,cellular_component methylcrotonoyl-CoA carboxylase complex	E6.4.1.4A; 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4]; K01968	methylcrotonoyl-CoA carboxylase 1 [Source:HGNC Symbol%3BAcc:HGNC:6936]
ENSG00000134330	90.97	79.89	85.77	98.33	88.08	98.16	-0.134815864979621	6.08600518338299	0.0611829659379462	0.335193464964963	2:9473657-9496543:+	IAH1	4;GO:0006629,biological_process lipid metabolic process;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	isoamyl acetate-hydrolyzing esterase 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:27696]
ENSG00000062725	33.77	34.61	34.00	32.02	32.10	30.86	0.119166694448524	5.87850126819069	0.0611897520027879	0.335193464964963	17:60443148-60526219:-	APPBP2	13;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0046907,biological_process intracellular transport	NA	amyloid beta precursor protein binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:622]
ENSG00000038427	118.81	135.07	122.64	103.70	129.30	106.37	0.16165048043655	10.2516940528202	0.0612878739874984	0.335582875962425	5:83471464-83582303:+	VCAN	27;GO:0001501,biological_process skeletal system development;GO:0001649,biological_process osteoblast differentiation;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0008037,biological_process cell recognition;GO:0016020,cellular_component membrane;GO:0030198,biological_process extracellular matrix organization;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0030246,molecular_function carbohydrate binding;GO:0031012,cellular_component extracellular matrix;GO:0043202,cellular_component lysosomal lumen;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process	VCAN, CSPG2; versican core protein; K06793	versican [Source:HGNC Symbol%3BAcc:HGNC:2464]
ENSG00000073350	7.50	7.60	8.40	7.32	6.70	7.17	0.162379711891608	4.62642499745716	0.0613517184322108	0.335748584532481	17:75525079-75575208:+	LLGL2	15;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0007049,biological_process cell cycle;GO:0017137,molecular_function Rab GTPase binding;GO:0017157,biological_process regulation of exocytosis;GO:0030165,molecular_function PDZ domain binding;GO:0032878,biological_process regulation of establishment or maintenance of cell polarity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050708,biological_process regulation of protein secretion;GO:0051301,biological_process cell division	LLGL; lethal(2) giant larvae protein; K06094	LLGL2%2C scribble cell polarity complex component [Source:HGNC Symbol%3BAcc:HGNC:6629]
ENSG00000183723	29.34	24.06	29.31	36.10	29.24	30.91	-0.19897879371445	4.40720327637702	0.0613722338116652	0.335748584532481	16:66614749-66696707:-	CMTM4	5;GO:0005125,molecular_function cytokine activity;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CKLF like MARVEL transmembrane domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:19175]
ENSG00000119900	106.70	99.94	106.57	115.05	110.82	116.57	-0.115982326977803	7.21093043345297	0.0615579321923702	0.336517164815937	6:71288802-71308950:+	OGFRL1	2;GO:0004872,molecular_function receptor activity;GO:0016020,cellular_component membrane	NA	opioid growth factor receptor like 1 [Source:HGNC Symbol%3BAcc:HGNC:21378]
ENSG00000178726	1.11	1.16	2.01	2.34	1.67	2.04	-0.477899364383309	1.65585368804978	0.0615916473466523	0.336517164815937	20:23045632-23049741:-	THBD	23;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005774,cellular_component vacuolar membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007565,biological_process female pregnancy;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0009986,cellular_component cell surface;GO:0010165,biological_process response to X-ray;GO:0010544,biological_process negative regulation of platelet activation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016327,cellular_component apicolateral plasma membrane;GO:0030195,biological_process negative regulation of blood coagulation;GO:0032496,biological_process response to lipopolysaccharide;GO:0050900,biological_process leukocyte migration;GO:0051591,biological_process response to cAMP;GO:0051918,biological_process negative regulation of fibrinolysis	THBD, CD141; thrombomodulin; K03907	thrombomodulin [Source:HGNC Symbol%3BAcc:HGNC:11784]
ENSG00000141298	5.71	5.96	5.32	5.10	5.25	4.99	0.15613582508549	4.61837782388628	0.0615940544962385	0.336517164815937	17:29625937-29930276:-	SSH2	17;GO:0003779,molecular_function actin binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006470,biological_process protein dephosphorylation;GO:0008064,biological_process regulation of actin polymerization or depolymerization;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0030335,biological_process positive regulation of cell migration;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0050770,biological_process regulation of axonogenesis	SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]; K05766	slingshot protein phosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:30580]
ENSG00000125798	14.24	13.90	13.94	12.61	12.67	12.55	0.165747693025146	4.22079857326613	0.0616250098793596	0.33653816437857	20:22581004-22585455:-	FOXA2	37;GO:0000432,biological_process positive regulation of transcription from RNA polymerase II promoter by glucose;GO:0000433,biological_process negative regulation of transcription from RNA polymerase II promoter by glucose;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001708,biological_process cell fate specification;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0008344,biological_process adult locomotory behavior;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0016569,biological_process covalent chromatin modification;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030193,biological_process regulation of blood coagulation;GO:0031018,biological_process endocrine pancreas development;GO:0033132,biological_process negative regulation of glucokinase activity;GO:0040019,biological_process positive regulation of embryonic development;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070741,biological_process response to interleukin-6;GO:0071542,biological_process dopaminergic neuron differentiation;GO:0090009,biological_process primitive streak formation;GO:2000049,biological_process positive regulation of cell-cell adhesion mediated by cadherin;GO:2000543,biological_process positive regulation of gastrulation;GO:2000971,biological_process negative regulation of detection of glucose	FOXA2, HNF3B; forkhead box protein A2, hepatocyte nuclear factor 3-beta; K08035	forkhead box A2 [Source:HGNC Symbol%3BAcc:HGNC:5022]
ENSG00000125676	24.40	24.42	23.58	21.77	23.98	21.03	0.128362164102218	6.84218576473463	0.0618377453080635	0.337551421507912	X:123600560-123733056:-	THOC2	28;GO:0000346,cellular_component transcription export complex;GO:0000347,cellular_component THO complex;GO:0000445,cellular_component THO complex part of transcription export complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000902,biological_process cell morphogenesis;GO:0001824,biological_process blastocyst development;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0010468,biological_process regulation of gene expression;GO:0010793,biological_process regulation of mRNA export from nucleus;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016607,cellular_component nuclear speck;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0017145,biological_process stem cell division;GO:0031124,biological_process mRNA 3'-end processing;GO:0046784,biological_process viral mRNA export from host cell nucleus;GO:0048666,biological_process neuron development;GO:0048699,biological_process generation of neurons;GO:0051028,biological_process mRNA transport	NA	THO complex 2 [Source:HGNC Symbol%3BAcc:HGNC:19073]
ENSG00000140945	43.88	42.34	43.02	40.98	37.36	41.39	0.122403402050303	6.80328106035991	0.0619953061471517	0.338262740749272	16:82626802-83800640:+	CDH13	43;GO:0000278,biological_process mitotic cell cycle;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002040,biological_process sprouting angiogenesis;GO:0005509,molecular_function calcium ion binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007266,biological_process Rho protein signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009897,cellular_component external side of plasma membrane;GO:0010033,biological_process response to organic substance;GO:0016020,cellular_component membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016601,biological_process Rac protein signal transduction;GO:0030032,biological_process lamellipodium assembly;GO:0030100,biological_process regulation of endocytosis;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030335,biological_process positive regulation of cell migration;GO:0031225,cellular_component anchored component of membrane;GO:0034332,biological_process adherens junction organization;GO:0042058,biological_process regulation of epidermal growth factor receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043542,biological_process endothelial cell migration;GO:0043616,biological_process keratinocyte proliferation;GO:0045296,molecular_function cadherin binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050850,biological_process positive regulation of calcium-mediated signaling;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0051668,biological_process localization within membrane;GO:0055096,biological_process low-density lipoprotein particle mediated signaling;GO:0055100,molecular_function adiponectin binding;GO:0070062,cellular_component extracellular exosome;GO:0071813,molecular_function lipoprotein particle binding	NA	cadherin 13 [Source:HGNC Symbol%3BAcc:HGNC:1753]
ENSG00000137168	37.30	40.30	35.47	42.10	44.01	41.80	-0.171621433428525	4.33272534062349	0.0622813952883362	0.339274944665998	6:36854826-36875024:-	PPIL1	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0006457,biological_process protein folding;GO:0008380,biological_process RNA splicing;GO:0016853,molecular_function isomerase activity;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097718,molecular_function disordered domain specific binding	NA	peptidylprolyl isomerase like 1 [Source:HGNC Symbol%3BAcc:HGNC:9260]
ENSG00000101040	21.81	21.69	21.42	23.71	23.54	23.63	-0.114962091727135	6.45600276448889	0.0622977733502442	0.339274944665998	20:47209213-47356889:-	ZMYND8	23;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030336,biological_process negative regulation of cell migration;GO:0035064,molecular_function methylated histone binding;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0070491,molecular_function repressing transcription factor binding;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0098815,biological_process modulation of excitatory postsynaptic potential;GO:1902897,biological_process regulation of postsynaptic density protein 95 clustering;GO:1902952,biological_process positive regulation of dendritic spine maintenance;GO:1903758,biological_process negative regulation of transcription from RNA polymerase II promoter by histone modification	NA	zinc finger MYND-type containing 8 [Source:HGNC Symbol%3BAcc:HGNC:9397]
ENSG00000196182	15.49	14.90	14.10	13.29	13.15	13.62	0.16269210278067	4.39432454696054	0.062302374240318	0.339274944665998	1:36339623-36385896:-	STK40	22;GO:0000166,molecular_function nucleotide binding;GO:0003016,biological_process respiratory system process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005977,biological_process glycogen metabolic process;GO:0006468,biological_process protein phosphorylation;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030324,biological_process lung development;GO:0035264,biological_process multicellular organism growth;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0048286,biological_process lung alveolus development;GO:0060425,biological_process lung morphogenesis	NA	serine/threonine kinase 40 [Source:HGNC Symbol%3BAcc:HGNC:21373]
ENSG00000143947	1121.62	990.39	989.70	1206.18	1047.67	1188.43	-0.138431084324469	9.26596213026239	0.062317103565517	0.339274944665998	2:55231902-55235853:+	RPS27A	110;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000187,biological_process activation of MAPK activity;GO:0000209,biological_process protein polyubiquitination;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0005978,biological_process glycogen biosynthetic process;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006457,biological_process protein folding;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007219,biological_process Notch signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019058,biological_process viral life cycle;GO:0019068,biological_process virion assembly;GO:0019083,biological_process viral transcription;GO:0019985,biological_process translesion synthesis;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031982,cellular_component vesicle;GO:0032479,biological_process regulation of type I interferon production;GO:0032480,biological_process negative regulation of type I interferon production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034220,biological_process ion transmembrane transport;GO:0035635,biological_process entry of bacterium into host cell;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0036297,biological_process interstrand cross-link repair;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043209,cellular_component myelin sheath;GO:0043488,biological_process regulation of mRNA stability;GO:0043657,cellular_component host cell;GO:0044267,biological_process cellular protein metabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0045087,biological_process innate immune response;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060544,biological_process regulation of necroptotic process;GO:0061024,biological_process membrane organization;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070987,biological_process error-free translesion synthesis;GO:0075733,biological_process intracellular transport of virus;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904380,biological_process endoplasmic reticulum mannose trimming	RP-S27Ae, RPS27A; small subunit ribosomal protein S27Ae; K02977	ribosomal protein S27a [Source:HGNC Symbol%3BAcc:HGNC:10417]
ENSG00000176476	11.91	11.73	10.65	13.48	14.21	12.37	-0.212479359499317	3.59336978270296	0.0623174795648493	0.339274944665998	16:28553914-28591790:+	SGF29	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0035064,molecular_function methylated histone binding;GO:0043966,biological_process histone H3 acetylation;GO:0070461,cellular_component SAGA-type complex;GO:0071169,biological_process establishment of protein localization to chromatin	NA	SAGA complex associated factor 29 [Source:HGNC Symbol%3BAcc:HGNC:25156]
ENSG00000107872	7.81	8.93	8.14	6.55	6.76	7.84	0.235915344169019	3.18084608938463	0.0624031074337857	0.33945137734646	10:102419188-102423136:+	FBXL15	13;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030282,biological_process bone mineralization;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 15 [Source:HGNC Symbol%3BAcc:HGNC:28155]
ENSG00000110651	166.83	176.49	169.98	154.98	166.16	156.16	0.116203812991731	7.71713886887429	0.0624304258869393	0.33945137734646	11:2376176-2397419:+	CD81	33;GO:0000187,biological_process activation of MAPK activity;GO:0001618,molecular_function virus receptor activity;GO:0001772,cellular_component immunological synapse;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008104,biological_process protein localization;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030449,biological_process regulation of complement activation;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031623,biological_process receptor internalization;GO:0031647,biological_process regulation of protein stability;GO:0031982,cellular_component vesicle;GO:0043128,biological_process positive regulation of 1-phosphatidylinositol 4-kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046718,biological_process viral entry into host cell;GO:0046813,biological_process receptor-mediated virion attachment to host cell;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050776,biological_process regulation of immune response;GO:0061462,biological_process protein localization to lysosome;GO:0070062,cellular_component extracellular exosome;GO:0071404,biological_process cellular response to low-density lipoprotein particle stimulus;GO:1904352,biological_process positive regulation of protein catabolic process in the vacuole;GO:1990459,molecular_function transferrin receptor binding;GO:2000145,biological_process regulation of cell motility	CD81, TAPA1, TSPAN28; CD81 antigen; K06508	CD81 molecule [Source:HGNC Symbol%3BAcc:HGNC:1701]
ENSG00000145715	23.21	21.68	21.68	25.48	22.48	25.61	-0.131822815484521	6.24438554905939	0.06243192576186	0.33945137734646	5:87267887-87391931:+	RASA1	30;GO:0000165,biological_process MAPK cascade;GO:0000281,biological_process mitotic cytokinesis;GO:0001570,biological_process vasculogenesis;GO:0001726,cellular_component ruffle;GO:0001784,molecular_function phosphotyrosine binding;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0009790,biological_process embryo development;GO:0019870,molecular_function potassium channel inhibitor activity;GO:0030833,biological_process regulation of actin filament polymerization;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0035556,biological_process intracellular signal transduction;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048514,biological_process blood vessel morphogenesis;GO:0051020,molecular_function GTPase binding;GO:0051252,biological_process regulation of RNA metabolic process	RASA1, RASGAP; Ras GTPase-activating protein 1; K04352	RAS p21 protein activator 1 [Source:HGNC Symbol%3BAcc:HGNC:9871]
ENSG00000169258	3.97	4.23	3.33	4.93	4.04	4.67	-0.237060132509115	3.68308444582933	0.0624880024059859	0.339469976564556	5:176595801-176610133:-	GPRIN1	6;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030426,cellular_component growth cone;GO:0031175,biological_process neuron projection development;GO:0042995,cellular_component cell projection;GO:0051219,molecular_function phosphoprotein binding	NA	G protein regulated inducer of neurite outgrowth 1 [Source:HGNC Symbol%3BAcc:HGNC:24835]
ENSG00000187959	8.11	8.06	7.60	7.84	5.18	5.93	0.337139500215486	2.33130317128256	0.0625333348764222	0.339469976564556	17:73248448-73262352:-	CPSF4L	7;GO:0003723,molecular_function RNA binding;GO:0004521,molecular_function endoribonuclease activity;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006378,biological_process mRNA polyadenylation;GO:0046872,molecular_function metal ion binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation	NA	cleavage and polyadenylation specific factor 4 like [Source:HGNC Symbol%3BAcc:HGNC:33632]
ENSG00000097033	68.52	67.99	65.61	63.57	59.99	64.08	0.11824190773277	6.29501491004547	0.0625562289375901	0.339469976564556	1:86704569-86748184:+	SH3GLB1	41;GO:0000139,cellular_component Golgi membrane;GO:0000421,cellular_component autophagosome membrane;GO:0005504,molecular_function fatty acid binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0008289,molecular_function lipid binding;GO:0008654,biological_process phospholipid biosynthetic process;GO:0010508,biological_process positive regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0030496,cellular_component midbody;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031647,biological_process regulation of protein stability;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0032465,biological_process regulation of cytokinesis;GO:0032801,biological_process receptor catabolic process;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042149,biological_process cellular response to glucose starvation;GO:0042171,molecular_function lysophosphatidic acid acyltransferase activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045296,molecular_function cadherin binding;GO:0048102,biological_process autophagic cell death;GO:0051084,biological_process 'de novo' posttranslational protein folding;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome;GO:0090148,biological_process membrane fission;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1903527,biological_process positive regulation of membrane tubulation;GO:1903778,biological_process protein localization to vacuolar membrane;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2000786,biological_process positive regulation of autophagosome assembly	SH3GLB1; endophilin-B1; K11248	SH3 domain containing GRB2 like%2C endophilin B1 [Source:HGNC Symbol%3BAcc:HGNC:10833]
ENSG00000149761	25.16	23.84	26.44	20.40	22.71	24.56	0.170786580494221	4.58984138882219	0.0625786809262324	0.339469976564556	11:64225940-64230686:+	NUDT22	3;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0016787,molecular_function hydrolase activity	NA	nudix hydrolase 22 [Source:HGNC Symbol%3BAcc:HGNC:28189]
ENSG00000108771	3.16	3.66	4.09	3.31	2.76	2.90	0.291075768191108	2.78091336762339	0.0625791496767721	0.339469976564556	17:42101403-42112733:-	DHX58	25;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0009615,biological_process response to virus;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032481,biological_process positive regulation of type I interferon production;GO:0039534,biological_process negative regulation of MDA-5 signaling pathway;GO:0039536,biological_process negative regulation of RIG-I signaling pathway;GO:0045087,biological_process innate immune response;GO:0045088,biological_process regulation of innate immune response;GO:0045824,biological_process negative regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:1900245,biological_process positive regulation of MDA-5 signaling pathway;GO:1900246,biological_process positive regulation of RIG-I signaling pathway	DHX58, LGP2; ATP-dependent RNA helicase DHX58 [EC:3.6.4.13]; K12649	DExH-box helicase 58 [Source:HGNC Symbol%3BAcc:HGNC:29517]
ENSG00000273841	42.54	38.25	37.73	44.90	41.18	46.79	-0.151432715032389	5.06230906818104	0.062599434170327	0.339469976564556	5:69364742-69370013:-	TAF9	40;GO:0000124,cellular_component SAGA complex;GO:0000125,cellular_component PCAF complex;GO:0000492,biological_process box C/D snoRNP assembly;GO:0001075,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0030307,biological_process positive regulation of cell growth;GO:0030914,cellular_component STAGA complex;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033276,cellular_component transcription factor TFTC complex;GO:0033613,molecular_function activating transcription factor binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043966,biological_process histone H3 acetylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0050821,biological_process protein stabilization;GO:0051117,molecular_function ATPase binding;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:0060760,biological_process positive regulation of response to cytokine stimulus;GO:0070555,biological_process response to interleukin-1;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0070761,cellular_component pre-snoRNP complex;GO:0071339,cellular_component MLL1 complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	TAF9; transcription initiation factor TFIID subunit 9; K14535	TATA-box binding protein associated factor 9 [Source:HGNC Symbol%3BAcc:HGNC:11542]
ENSG00000212907	8320.15	8989.66	8810.86	8161.30	8371.56	7789.29	0.114638355253106	11.2726400536404	0.0627726849510892	0.340171432529284	MT:10469-10766:+	MT-ND4L	12;GO:0005739,cellular_component mitochondrion;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0031966,cellular_component mitochondrial membrane;GO:0042773,biological_process ATP synthesis coupled electron transport;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]; K03882	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L [Source:HGNC Symbol%3BAcc:HGNC:7460]
ENSG00000073111	27.16	26.84	26.30	30.38	27.41	30.44	-0.124565510364374	6.37084388970229	0.0628101646574644	0.340171432529284	3:127598222-127622436:+	MCM2	30;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003688,molecular_function DNA replication origin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006334,biological_process nucleosome assembly;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0032508,biological_process DNA duplex unwinding;GO:0042393,molecular_function histone binding;GO:0042555,cellular_component MCM complex;GO:0046872,molecular_function metal ion binding;GO:0071353,biological_process cellular response to interleukin-4;GO:0090102,biological_process cochlea development	MCM2; DNA replication licensing factor MCM2 [EC:3.6.4.12]; K02540	minichromosome maintenance complex component 2 [Source:HGNC Symbol%3BAcc:HGNC:6944]
ENSG00000154222	17.99	18.55	17.80	17.10	16.55	16.55	0.124585436982745	5.51799405563206	0.0628217571443667	0.340171432529284	1:52345722-52366193:-	CC2D1B	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	coiled-coil and C2 domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:29386]
ENSG00000137133	26.86	26.77	30.40	34.91	27.30	37.39	-0.232731537195119	3.92418502585948	0.0628384028671271	0.340171432529284	9:35812959-35815354:-	HINT2	10;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0016787,molecular_function hydrolase activity;GO:0044240,biological_process multicellular organism lipid catabolic process;GO:2000757,biological_process negative regulation of peptidyl-lysine acetylation	NA	histidine triad nucleotide binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18344]
ENSG00000118873	11.86	10.79	12.09	10.51	11.17	10.25	0.13776563027322	5.57398712655627	0.0628875289225016	0.340288969710119	1:220148292-220272454:-	RAB3GAP2	21;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0008047,molecular_function enzyme activator activity;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030234,molecular_function enzyme regulator activity;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043087,biological_process regulation of GTPase activity;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0061024,biological_process membrane organization;GO:0097051,biological_process establishment of protein localization to endoplasmic reticulum membrane;GO:1903061,biological_process positive regulation of protein lipidation;GO:1903373,biological_process positive regulation of endoplasmic reticulum tubular network organization;GO:2000786,biological_process positive regulation of autophagosome assembly	NA	RAB3 GTPase activating non-catalytic protein subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:17168]
ENSG00000167005	73.32	71.29	68.52	79.05	76.18	78.89	-0.123921079152449	5.67155059967682	0.0629647044554136	0.340558116080631	16:56429132-56452199:-	NUDT21	21;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005849,cellular_component mRNA cleavage factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0017091,molecular_function AU-rich element binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0042382,cellular_component paraspeckles;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0051262,biological_process protein tetramerization	NUDT21, CPSF5, CFIM25; cleavage and polyadenylation specificity factor subunit 5; K14397	nudix hydrolase 21 [Source:HGNC Symbol%3BAcc:HGNC:13870]
ENSG00000122545	197.23	186.49	193.53	210.14	204.22	213.43	-0.108892885263669	8.15964245191716	0.0631708004388643	0.341465540843803	7:35800931-35907105:+	SEPT7	37;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000910,biological_process cytokinesis;GO:0001725,cellular_component stress fiber;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0015629,cellular_component actin cytoskeleton;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016324,cellular_component apical plasma membrane;GO:0016476,biological_process regulation of embryonic cell shape;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0031105,cellular_component septin complex;GO:0032154,cellular_component cleavage furrow;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0051291,biological_process protein heterooligomerization;GO:0051301,biological_process cell division;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097227,cellular_component sperm annulus;GO:0097730,cellular_component non-motile cilium;GO:1902857,biological_process positive regulation of nonmotile primary cilium assembly	SEPT7, CDC3; septin 7; K16944	septin 7 [Source:HGNC Symbol%3BAcc:HGNC:1717]
ENSG00000188818	1.76	1.25	1.76	1.52	1.03	1.02	0.449978093484562	1.69673751711917	0.0632019607433268	0.341465540843803	5:795605-850986:-	ZDHHC11	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 11 [Source:HGNC Symbol%3BAcc:HGNC:19158]
ENSG00000157500	24.74	21.72	25.02	26.29	25.71	27.17	-0.131525231253542	5.74833746703674	0.0632150014387383	0.341465540843803	3:57227736-57273468:+	APPL1	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0016581,cellular_component NuRD complex;GO:0031901,cellular_component early endosome membrane;GO:0042802,molecular_function identical protein binding;GO:0043422,molecular_function protein kinase B binding;GO:0046324,biological_process regulation of glucose import;GO:0070062,cellular_component extracellular exosome;GO:0090003,biological_process regulation of establishment of protein localization to plasma membrane;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand	APPL1, DIP13A; DCC-interacting protein 13 alpha; K08733	adaptor protein%2C phosphotyrosine interacting with PH domain and leucine zipper 1 [Source:HGNC Symbol%3BAcc:HGNC:24035]
ENSG00000174917	47.45	48.41	43.45	45.68	39.09	38.88	0.18157284239918	4.32292603120226	0.0632483759277281	0.341497212001257	19:5678420-5680896:-	C19orf70	8;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042407,biological_process cristae formation;GO:0044284,cellular_component mitochondrial crista junction;GO:0061617,cellular_component MICOS complex	NA	chromosome 19 open reading frame 70 [Source:HGNC Symbol%3BAcc:HGNC:33702]
ENSG00000135972	35.43	34.42	37.04	38.04	38.60	41.33	-0.129349567794091	5.53382046954279	0.0632855501212555	0.34154481422933	2:105037982-105099960:+	MRPS9	14;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9; K02996	mitochondrial ribosomal protein S9 [Source:HGNC Symbol%3BAcc:HGNC:14501]
ENSG00000271425	2.01	1.89	2.43	1.98	1.73	1.87	0.19737565968479	4.53545037090086	0.0633122224717384	0.34154481422933	1:146064698-146144804:-	NBPF10	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	NBPF member 10 [Source:HGNC Symbol%3BAcc:HGNC:31992]
ENSG00000165487	31.89	30.35	31.51	28.79	30.42	26.72	0.140215185857203	5.32054785526124	0.0633515638536354	0.341608584758982	13:21492690-21604214:-	MICU2	14;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0034704,cellular_component calcium channel complex;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0046982,molecular_function protein heterodimerization activity;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0051562,biological_process negative regulation of mitochondrial calcium ion concentration;GO:1990246,cellular_component uniplex complex	NA	mitochondrial calcium uptake 2 [Source:HGNC Symbol%3BAcc:HGNC:31830]
ENSG00000183779	6.74	7.72	7.24	5.37	6.26	6.95	0.227604925490739	3.58497662793053	0.0634069333124184	0.341758690059509	8:37695750-37700021:+	ZNF703	22;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016363,cellular_component nuclear matrix;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030335,biological_process positive regulation of cell migration;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0034111,biological_process negative regulation of homotypic cell-cell adhesion;GO:0034333,biological_process adherens junction assembly;GO:0043234,cellular_component protein complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0070491,molecular_function repressing transcription factor binding;GO:0071392,biological_process cellular response to estradiol stimulus	NA	zinc finger protein 703 [Source:HGNC Symbol%3BAcc:HGNC:25883]
ENSG00000112667	19.69	24.61	20.52	23.49	24.08	27.25	-0.206730715431668	4.2288161153739	0.0634708923749722	0.341820871257511	6:43225628-43229484:-	DNPH1	18;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006195,biological_process purine nucleotide catabolic process;GO:0008152,biological_process metabolic process;GO:0008283,biological_process cell proliferation;GO:0009117,biological_process nucleotide metabolic process;GO:0009159,biological_process deoxyribonucleoside monophosphate catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030307,biological_process positive regulation of cell growth;GO:0030855,biological_process epithelial cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0050144,molecular_function nucleoside deoxyribosyltransferase activity;GO:0070062,cellular_component extracellular exosome;GO:0070694,molecular_function deoxyribonucleoside 5'-monophosphate N-glycosidase activity	NA	2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:21218]
ENSG00000115902	35.49	33.77	32.79	35.61	37.78	38.86	-0.125309819898587	5.83854963378846	0.0634735445298126	0.341820871257511	2:64988476-65023865:+	SLC1A4	37;GO:0003333,biological_process amino acid transmembrane transport;GO:0005254,molecular_function chloride channel activity;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006821,biological_process chloride transport;GO:0006865,biological_process amino acid transport;GO:0006868,biological_process glutamine transport;GO:0009986,cellular_component cell surface;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015180,molecular_function L-alanine transmembrane transporter activity;GO:0015184,molecular_function L-cystine transmembrane transporter activity;GO:0015186,molecular_function L-glutamine transmembrane transporter activity;GO:0015193,molecular_function L-proline transmembrane transporter activity;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015195,molecular_function L-threonine transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015808,biological_process L-alanine transport;GO:0015811,biological_process L-cystine transport;GO:0015824,biological_process proline transport;GO:0015825,biological_process L-serine transport;GO:0015826,biological_process threonine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0034589,biological_process hydroxyproline transport;GO:0034590,molecular_function L-hydroxyproline transmembrane transporter activity;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035524,biological_process proline transmembrane transport;GO:0042470,cellular_component melanosome;GO:0043025,cellular_component neuronal cell body;GO:0050890,biological_process cognition;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 1 member 4 [Source:HGNC Symbol%3BAcc:HGNC:10942]
ENSG00000277481	0.34	0.33	0.50	0.23	0.31	0.28	0.526734022481889	0.906741107029062	0.063597334596183	0.342338991475464	16:71929537-71999978:-	PKD1L3	23;GO:0001581,biological_process detection of chemical stimulus involved in sensory perception of sour taste;GO:0001822,biological_process kidney development;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0033040,molecular_function sour taste receptor activity;GO:0034703,cellular_component cation channel complex;GO:0043235,cellular_component receptor complex;GO:0050915,biological_process sensory perception of sour taste;GO:0050982,biological_process detection of mechanical stimulus;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071468,biological_process cellular response to acidic pH	PKD1L3; polycystin 1L3; K04989	polycystin 1 like 3%2C transient receptor potential channel interacting [Source:HGNC Symbol%3BAcc:HGNC:21716]
ENSG00000163449	3.41	4.08	2.64	4.12	4.77	4.34	-0.391440365959235	1.85251253913346	0.0636310739941738	0.342372137620147	2:216081865-216102783:+	TMEM169	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 169 [Source:HGNC Symbol%3BAcc:HGNC:25130]
ENSG00000176407	54.13	53.18	56.15	64.85	54.54	62.01	-0.138064026130953	6.04303054105787	0.063665358443572	0.342408186464497	2:84971092-85059472:+	KCMF1	7;GO:0003676,molecular_function nucleic acid binding;GO:0005576,cellular_component extracellular region;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	potassium channel modulatory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:20589]
ENSG00000092439	16.34	16.02	15.74	14.20	14.93	15.53	0.118943342422492	6.46353893717692	0.0637112405456272	0.342506552140698	15:50552472-50686815:-	TRPM7	31;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005216,molecular_function ion channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005524,molecular_function ATP binding;GO:0005623,cellular_component cell;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0010961,biological_process cellular magnesium ion homeostasis;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016340,biological_process calcium-dependent cell-matrix adhesion;GO:0016740,molecular_function transferase activity;GO:0017022,molecular_function myosin binding;GO:0031032,biological_process actomyosin structure organization;GO:0034220,biological_process ion transmembrane transport;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051262,biological_process protein tetramerization;GO:0055085,biological_process transmembrane transport;GO:0070266,biological_process necroptotic process;GO:0070588,biological_process calcium ion transmembrane transport	TRPM7, CHAK1; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1]; K04982	transient receptor potential cation channel subfamily M member 7 [Source:HGNC Symbol%3BAcc:HGNC:17994]
ENSG00000147364	24.25	18.05	20.72	24.48	24.11	23.89	-0.180525267197308	4.65170266654204	0.0638576650456346	0.342549950395786	8:406427-477967:+	FBXO25	6;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex	FBXO25_32; F-box protein 25/32; K10305	F-box protein 25 [Source:HGNC Symbol%3BAcc:HGNC:13596]
ENSG00000183287	6.14	5.33	5.25	7.86	6.03	6.57	-0.274592340814701	2.95305887485142	0.063893271986609	0.342549950395786	18:59430939-59697380:-	CCBE1	23;GO:0001525,biological_process angiogenesis;GO:0001945,biological_process lymph vessel development;GO:0001946,biological_process lymphangiogenesis;GO:0002020,molecular_function protease binding;GO:0002040,biological_process sprouting angiogenesis;GO:0003016,biological_process respiratory system process;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0007585,biological_process respiratory gaseous exchange;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010954,biological_process positive regulation of protein processing;GO:0030324,biological_process lung development;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048845,biological_process venous blood vessel morphogenesis;GO:1900748,biological_process positive regulation of vascular endothelial growth factor signaling pathway;GO:1901492,biological_process positive regulation of lymphangiogenesis	NA	collagen and calcium binding EGF domains 1 [Source:HGNC Symbol%3BAcc:HGNC:29426]
ENSG00000168038	3.19	2.31	2.80	3.97	2.86	3.30	-0.26593601224688	3.61926966037179	0.0639160534454246	0.342549950395786	3:41246598-41962430:-	ULK4	15;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0010975,biological_process regulation of neuron projection development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043408,biological_process regulation of MAPK cascade;GO:0046328,biological_process regulation of JNK cascade;GO:0090036,biological_process regulation of protein kinase C signaling;GO:1900744,biological_process regulation of p38MAPK cascade;GO:2001222,biological_process regulation of neuron migration	NA	unc-51 like kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:15784]
ENSG00000185100	12.24	9.32	12.46	9.57	9.50	10.73	0.210814501643606	4.41259813567093	0.0639171886567002	0.342549950395786	14:104724185-104747325:+	ADSSL1	26;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003924,molecular_function GTPase activity;GO:0004019,molecular_function adenylosuccinate synthase activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006163,biological_process purine nucleotide metabolic process;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006167,biological_process AMP biosynthetic process;GO:0006531,biological_process aspartate metabolic process;GO:0006541,biological_process glutamine metabolic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0014850,biological_process response to muscle activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0035690,biological_process cellular response to drug;GO:0042301,molecular_function phosphate ion binding;GO:0042594,biological_process response to starvation;GO:0042803,molecular_function protein homodimerization activity;GO:0044208,biological_process 'de novo' AMP biosynthetic process;GO:0046040,biological_process IMP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0071257,biological_process cellular response to electrical stimulus	purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]; K01939	adenylosuccinate synthase like 1 [Source:HGNC Symbol%3BAcc:HGNC:20093]
ENSG00000175197	251.48	173.38	240.99	285.97	223.18	274.44	-0.221731181594028	7.12539910645753	0.0639194483083691	0.342549950395786	12:57516587-57520517:-	DDIT3	67;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001955,biological_process blood vessel maturation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006983,biological_process ER overload response;GO:0006986,biological_process response to unfolded protein;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008134,molecular_function transcription factor binding;GO:0008140,molecular_function cAMP response element binding protein binding;GO:0016055,biological_process Wnt signaling pathway;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032792,biological_process negative regulation of CREB transcription factor activity;GO:0032993,cellular_component protein-DNA complex;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035976,cellular_component AP1 complex;GO:0036488,cellular_component CHOP-C/EBP complex;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0042594,biological_process response to starvation;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043392,biological_process negative regulation of DNA binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043522,molecular_function leucine zipper domain binding;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043620,biological_process regulation of DNA-templated transcription in response to stress;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044324,biological_process regulation of transcription involved in anterior/posterior axis specification;GO:0045454,biological_process cell redox homeostasis;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051259,biological_process protein oligomerization;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0072655,biological_process establishment of protein localization to mitochondrion;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1901216,biological_process positive regulation of neuron death;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903026,biological_process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:1990442,biological_process intrinsic apoptotic signaling pathway in response to nitrosative stress;GO:1990617,cellular_component CHOP-ATF4 complex;GO:1990622,cellular_component CHOP-ATF3 complex;GO:2000016,biological_process negative regulation of determination of dorsal identity	DDIT3, GADD153; DNA damage-inducible transcript 3; K04452	DNA damage inducible transcript 3 [Source:HGNC Symbol%3BAcc:HGNC:2726]
ENSG00000166575	12.21	13.55	11.84	10.61	12.02	10.81	0.175108897203805	4.31393587705954	0.0639231036939863	0.342549950395786	11:87037843-87323758:+	TMEM135	11;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005811,cellular_component lipid particle;GO:0007031,biological_process peroxisome organization;GO:0009409,biological_process response to cold;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032094,biological_process response to food;GO:0090140,biological_process regulation of mitochondrial fission	NA	transmembrane protein 135 [Source:HGNC Symbol%3BAcc:HGNC:26167]
ENSG00000173153	16.37	14.11	13.59	12.35	14.12	12.37	0.198302750751908	4.14980038896024	0.0639303401687153	0.342549950395786	11:64305571-64316743:+	ESRRA	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005496,molecular_function steroid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007005,biological_process mitochondrion organization;GO:0008270,molecular_function zinc ion binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019904,molecular_function protein domain specific binding;GO:0030278,biological_process regulation of ossification;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032355,biological_process response to estradiol;GO:0042127,biological_process regulation of cell proliferation;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045171,cellular_component intercellular bridge;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051216,biological_process cartilage development;GO:1900078,biological_process positive regulation of cellular response to insulin stimulus	NA	estrogen related receptor alpha [Source:HGNC Symbol%3BAcc:HGNC:3471]
ENSG00000166169	13.39	13.87	14.30	12.20	13.11	12.41	0.151423100647876	4.66479398677711	0.0639560420901068	0.342549950395786	10:101578881-101588270:-	POLL	19;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006287,biological_process base-excision repair, gap-filling;GO:0006289,biological_process nucleotide-excision repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016829,molecular_function lyase activity;GO:0034061,molecular_function DNA polymerase activity;GO:0046872,molecular_function metal ion binding;GO:0051575,molecular_function 5'-deoxyribose-5-phosphate lyase activity;GO:0071897,biological_process DNA biosynthetic process	POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]; K03512	DNA polymerase lambda [Source:HGNC Symbol%3BAcc:HGNC:9184]
ENSG00000110841	28.47	27.96	29.91	31.06	30.37	33.42	-0.123146139717384	6.65529185809385	0.0639676778391551	0.342549950395786	12:27523430-27695564:+	PPFIBP1	5;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0045296,molecular_function cadherin binding	NA	PPFIA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9249]
ENSG00000115255	21.20	20.53	18.72	22.71	24.44	22.55	-0.193824183823532	3.79727417175031	0.0640472133169352	0.342731637195923	19:1490746-1497927:+	REEP6	13;GO:0001917,cellular_component photoreceptor inner segment;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032386,biological_process regulation of intracellular transport;GO:0044317,cellular_component rod spherule;GO:0045177,cellular_component apical part of cell;GO:0050908,biological_process detection of light stimulus involved in visual perception	NA	receptor accessory protein 6 [Source:HGNC Symbol%3BAcc:HGNC:30078]
ENSG00000170322	10.77	10.31	10.53	9.42	10.17	9.55	0.131092535612907	5.3477810102685	0.0640765358288779	0.342731637195923	11:129863635-129895590:-	NFRKB	14;GO:0002020,molecular_function protease binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016579,biological_process protein deubiquitination;GO:0031011,cellular_component Ino80 complex	NA	nuclear factor related to kappaB binding protein [Source:HGNC Symbol%3BAcc:HGNC:7802]
ENSG00000099783	110.12	116.52	103.63	119.00	130.25	115.20	-0.130857208112163	8.05149595638515	0.0640848885367967	0.342731637195923	19:8444766-8489114:+	HNRNPM	22;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005887,cellular_component integral component of plasma membrane;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0016363,cellular_component nuclear matrix;GO:0019904,molecular_function protein domain specific binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0042382,cellular_component paraspeckles;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome	HNRNPM; heterogeneous nuclear ribonucleoprotein M; K12887	heterogeneous nuclear ribonucleoprotein M [Source:HGNC Symbol%3BAcc:HGNC:5046]
ENSG00000157426	8.00	7.87	7.98	8.97	9.30	8.39	-0.147072474740737	4.81795988595965	0.0641280783530894	0.342731637195923	4:56338286-56387508:-	AASDH	10;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005524,molecular_function ATP binding;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0008152,biological_process metabolic process;GO:0016874,molecular_function ligase activity;GO:0016878,molecular_function acid-thiol ligase activity;GO:0019482,biological_process beta-alanine metabolic process;GO:0043041,biological_process amino acid activation for nonribosomal peptide biosynthetic process	NA	aminoadipate-semialdehyde dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:23993]
ENSG00000102900	21.48	22.78	20.91	24.72	24.08	22.83	-0.126570203484809	5.99045224013711	0.0641396594865164	0.342731637195923	16:56730104-56850286:+	NUP93	31;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0006998,biological_process nuclear envelope organization;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0051292,biological_process nuclear pore complex assembly;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060395,biological_process SMAD protein signal transduction;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0072001,biological_process renal system development;GO:0072015,biological_process glomerular visceral epithelial cell development;GO:0075733,biological_process intracellular transport of virus;GO:0090521,biological_process glomerular visceral epithelial cell migration;GO:1900034,biological_process regulation of cellular response to heat;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death	NUP93, NIC96; nuclear pore complex protein Nup93; K14309	nucleoporin 93 [Source:HGNC Symbol%3BAcc:HGNC:28958]
ENSG00000122912	10.29	10.95	11.32	9.44	10.12	8.92	0.205088402012606	3.65046718299381	0.064190911177806	0.342857908971646	10:68477998-68527474:-	SLC25A16	11;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0009108,biological_process coenzyme biosynthetic process;GO:0015291,molecular_function secondary active transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 16 [Source:HGNC Symbol%3BAcc:HGNC:10986]
ENSG00000172572	0.27	0.17	0.15	0.26	0.42	0.33	-0.74450622115078	0.105982872351646	0.0642820863426059	0.343197220546566	12:20369244-20684381:+	PDE3A	27;GO:0001556,biological_process oocyte maturation;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004119,molecular_function cGMP-inhibited cyclic-nucleotide phosphodiesterase activity;GO:0005829,cellular_component cytosol;GO:0006198,biological_process cAMP catabolic process;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016101,biological_process diterpenoid metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019933,biological_process cAMP-mediated signaling;GO:0019934,biological_process cGMP-mediated signaling;GO:0030552,molecular_function cAMP binding;GO:0040020,biological_process regulation of meiotic nuclear division;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043116,biological_process negative regulation of vascular permeability;GO:0043117,biological_process positive regulation of vascular permeability;GO:0046872,molecular_function metal ion binding;GO:0047555,molecular_function 3',5'-cyclic-GMP phosphodiesterase activity;GO:0051591,biological_process response to cAMP;GO:0060282,biological_process positive regulation of oocyte development;GO:0071321,biological_process cellular response to cGMP;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus	PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17]; K13296	phosphodiesterase 3A [Source:HGNC Symbol%3BAcc:HGNC:8778]
ENSG00000103316	11.24	15.21	11.86	9.76	12.38	9.67	0.269744611793405	3.51527251211802	0.0643286565772409	0.343298200384046	16:21238873-21303083:-	CRYM	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005782,cellular_component peroxisomal matrix;GO:0005829,cellular_component cytosol;GO:0006554,biological_process lysine catabolic process;GO:0007605,biological_process sensory perception of sound;GO:0016491,molecular_function oxidoreductase activity;GO:0016639,molecular_function oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor;GO:0042403,biological_process thyroid hormone metabolic process;GO:0042562,molecular_function hormone binding;GO:0042803,molecular_function protein homodimerization activity;GO:0047127,molecular_function thiomorpholine-carboxylate dehydrogenase activity;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070324,molecular_function thyroid hormone binding;GO:0070327,biological_process thyroid hormone transport	NA	crystallin mu [Source:HGNC Symbol%3BAcc:HGNC:2418]
ENSG00000184897	132.08	104.54	120.02	139.32	117.50	149.77	-0.175071484785839	6.35119028457458	0.0643957262170928	0.343508444148162	3:129314770-129316277:-	H1FX	8;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006334,biological_process nucleosome assembly;GO:0045296,molecular_function cadherin binding	NA	H1 histone family member X [Source:HGNC Symbol%3BAcc:HGNC:4722]
ENSG00000164099	0.75	0.62	0.59	0.77	1.27	0.80	-0.511237088002022	1.18053543916699	0.064447279468674	0.343635773215056	4:118280037-118353003:-	PRSS12	18;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006887,biological_process exocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031638,biological_process zymogen activation;GO:0043083,cellular_component synaptic cleft;GO:0043195,cellular_component terminal bouton;GO:0045202,cellular_component synapse	NA	protease%2C serine 12 [Source:HGNC Symbol%3BAcc:HGNC:9477]
ENSG00000174373	4.56	4.01	4.94	4.10	3.85	4.26	0.162700439744503	5.08007872448636	0.0644841351260867	0.34368465835986	14:35538351-35809304:-	RALGAPA1	8;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0090630,biological_process activation of GTPase activity	NA	Ral GTPase activating protein catalytic alpha subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:17770]
ENSG00000131015	6.89	8.16	7.78	5.38	6.06	6.96	0.311219941614745	2.37805459998823	0.0645753593676249	0.34383631502101	6:149941999-149949235:+	ULBP2	11;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0030101,biological_process natural killer cell activation;GO:0031225,cellular_component anchored component of membrane;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0046658,cellular_component anchored component of plasma membrane;GO:0046703,molecular_function natural killer cell lectin-like receptor binding	ULBP; UL16 binding protein; K07986	UL16 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:14894]
ENSG00000165186	1.01	1.33	1.60	1.63	1.65	1.82	-0.367588274928367	2.06300652447392	0.0646078865575453	0.34383631502101	X:23334015-23404372:+	PTCHD1	8;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021794,biological_process thalamus development;GO:0035176,biological_process social behavior;GO:0050890,biological_process cognition	NA	patched domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26392]
ENSG00000130713	24.27	20.66	28.22	29.39	26.40	29.04	-0.194412906286858	4.54913587470529	0.0646348567662226	0.34383631502101	9:130693720-130704894:+	EXOSC2	24;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000467,biological_process exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0008312,molecular_function 7S RNA binding;GO:0030307,biological_process positive regulation of cell growth;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0071034,biological_process CUT catabolic process;GO:0071035,biological_process nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038,biological_process nuclear polyadenylation-dependent tRNA catabolic process;GO:0071049,biological_process nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription;GO:0071051,biological_process polyadenylation-dependent snoRNA 3'-end processing	RRP4, EXOSC2; exosome complex component RRP4; K03679	exosome component 2 [Source:HGNC Symbol%3BAcc:HGNC:17097]
ENSG00000160953	24.76	20.64	23.10	19.71	22.13	20.64	0.149377789026577	5.66290517024203	0.0646494709791099	0.34383631502101	19:1354710-1378431:+	MUM1	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006325,biological_process chromatin organization;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0031491,molecular_function nucleosome binding	NA	melanoma associated antigen (mutated) 1 [Source:HGNC Symbol%3BAcc:HGNC:29641]
ENSG00000134815	8.91	8.60	9.54	8.03	8.28	8.39	0.145743454379994	4.91573040629794	0.0646705341809411	0.34383631502101	19:47349280-47382704:+	DHX34	11;GO:0000166,molecular_function nucleotide binding;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:2000623,biological_process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	NA	DExH-box helicase 34 [Source:HGNC Symbol%3BAcc:HGNC:16719]
ENSG00000163512	42.77	40.14	43.07	39.75	36.43	40.14	0.128589355825499	5.74839233211453	0.0646787880104777	0.34383631502101	3:28315002-28349127:-	AZI2	13;GO:0000278,biological_process mitotic cell cycle;GO:0001816,biological_process cytokine production;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0016032,biological_process viral process;GO:0032607,biological_process interferon-alpha production;GO:0032609,biological_process interferon-gamma production;GO:0032635,biological_process interleukin-6 production;GO:0032640,biological_process tumor necrosis factor production;GO:0042110,biological_process T cell activation;GO:0044565,biological_process dendritic cell proliferation;GO:0097028,biological_process dendritic cell differentiation	AZI2; 5-azacytidine-induced protein 2; K12651	5-azacytidine induced 2 [Source:HGNC Symbol%3BAcc:HGNC:24002]
ENSG00000115325	17.77	20.20	17.39	16.91	16.71	16.13	0.159046652383979	4.66473525616659	0.0648434402724433	0.344305832967839	2:74549025-74557554:+	DOK1	14;GO:0005057,molecular_function receptor signaling protein activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007411,biological_process axon guidance;GO:0035556,biological_process intracellular signal transduction;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	docking protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2990]
ENSG00000197170	51.40	50.32	48.75	57.39	52.96	54.56	-0.120524409243211	6.19743304792118	0.064845050091004	0.344305832967839	17:67337915-67366627:-	PSMD12	38;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031595,cellular_component nuclear proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD12, RPN5; 26S proteasome regulatory subunit N5; K03035	proteasome 26S subunit%2C non-ATPase 12 [Source:HGNC Symbol%3BAcc:HGNC:9557]
ENSG00000198945	3.93	3.13	3.91	3.98	4.22	5.06	-0.252674252717924	3.33702129940757	0.0648564851937038	0.344305832967839	6:130013698-130141451:+	L3MBTL3	13;GO:0003674,molecular_function molecular_function;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0030099,biological_process myeloid cell differentiation;GO:0030225,biological_process macrophage differentiation;GO:0030851,biological_process granulocyte differentiation;GO:0043249,biological_process erythrocyte maturation	NA	L3MBTL3%2C histone methyl-lysine binding protein [Source:HGNC Symbol%3BAcc:HGNC:23035]
ENSG00000121774	76.42	90.96	81.63	89.74	99.92	87.94	-0.146941565435304	6.86784132198665	0.0648780587538691	0.344305832967839	1:32013828-32060850:+	KHDRBS1	34;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0008143,molecular_function poly(A) binding;GO:0008266,molecular_function poly(U) RNA binding;GO:0008283,biological_process cell proliferation;GO:0009967,biological_process positive regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0019904,molecular_function protein domain specific binding;GO:0032403,molecular_function protein complex binding;GO:0042802,molecular_function identical protein binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045948,biological_process positive regulation of translational initiation;GO:0046831,biological_process regulation of RNA export from nucleus;GO:0046833,biological_process positive regulation of RNA export from nucleus;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0051259,biological_process protein oligomerization;GO:0070618,cellular_component Grb2-Sos complex	NA	KH RNA binding domain containing%2C signal transduction associated 1 [Source:HGNC Symbol%3BAcc:HGNC:18116]
ENSG00000134453	57.46	54.32	61.54	67.16	58.39	66.88	-0.137701636373299	6.34619667799491	0.0650597228091336	0.344868538750431	10:6088986-6117457:+	RBM17	13;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006281,biological_process DNA repair;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0043234,cellular_component protein complex;GO:0043484,biological_process regulation of RNA splicing	RBM17, SPF45; splicing factor 45; K12840	RNA binding motif protein 17 [Source:HGNC Symbol%3BAcc:HGNC:16944]
ENSG00000052126	34.56	37.48	35.12	30.29	35.49	32.69	0.13297317213345	7.05792259186647	0.0650624788252605	0.344868538750431	12:19129751-19376400:+	PLEKHA5	11;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0016020,cellular_component membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0061458,biological_process reproductive system development;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	pleckstrin homology domain containing A5 [Source:HGNC Symbol%3BAcc:HGNC:30036]
ENSG00000144791	8.08	7.18	8.27	7.04	6.83	7.05	0.187862951831817	3.95147096525655	0.0650674387942891	0.344868538750431	3:45555393-45686338:+	LIMD1	34;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001666,biological_process response to hypoxia;GO:0002076,biological_process osteoblast development;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0008360,biological_process regulation of cell shape;GO:0016310,biological_process phosphorylation;GO:0016442,cellular_component RISC complex;GO:0016477,biological_process cell migration;GO:0030054,cellular_component cell junction;GO:0031047,biological_process gene silencing by RNA;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0035195,biological_process gene silencing by miRNA;GO:0035331,biological_process negative regulation of hippo signaling;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000637,biological_process positive regulation of gene silencing by miRNA	AJUBA, LIMD1, WTIP; LIM domain-containing protein; K16682	LIM domains containing 1 [Source:HGNC Symbol%3BAcc:HGNC:6612]
ENSG00000177830	64.49	66.38	68.29	63.58	61.05	60.33	0.118437192693036	6.44608315915749	0.0651116892497775	0.344955782610964	11:867859-915058:-	CHID1	19;GO:0002376,biological_process immune system process;GO:0002576,biological_process platelet degranulation;GO:0004568,molecular_function chitinase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005764,cellular_component lysosome;GO:0005770,cellular_component late endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005975,biological_process carbohydrate metabolic process;GO:0006032,biological_process chitin catabolic process;GO:0008061,molecular_function chitin binding;GO:0016020,cellular_component membrane;GO:0043202,cellular_component lysosomal lumen;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome;GO:0070492,molecular_function oligosaccharide binding;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response	NA	chitinase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28474]
ENSG00000160877	30.11	29.98	28.96	32.01	32.86	32.74	-0.121352163575611	5.62586410233886	0.065157688542948	0.345052213260927	19:13118102-13141141:+	NACC1	11;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016604,cellular_component nuclear body;GO:0030054,cellular_component cell junction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051260,biological_process protein homooligomerization	NA	nucleus accumbens associated 1 [Source:HGNC Symbol%3BAcc:HGNC:20967]
ENSG00000107201	11.76	11.02	10.93	9.47	10.60	10.59	0.149311931674897	4.9039207760436	0.0653288422335182	0.345791337592083	9:32455704-32526324:-	DDX58	53;GO:0000166,molecular_function nucleotide binding;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0008270,molecular_function zinc ion binding;GO:0009597,biological_process detection of virus;GO:0009615,biological_process response to virus;GO:0010628,biological_process positive regulation of gene expression;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030054,cellular_component cell junction;GO:0030334,biological_process regulation of cell migration;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032587,cellular_component ruffle membrane;GO:0032725,biological_process positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0034344,biological_process regulation of type III interferon production;GO:0035549,biological_process positive regulation of interferon-beta secretion;GO:0039528,biological_process cytoplasmic pattern recognition receptor signaling pathway in response to virus;GO:0039529,biological_process RIG-I signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0042995,cellular_component cell projection;GO:0043330,biological_process response to exogenous dsRNA;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0060760,biological_process positive regulation of response to cytokine stimulus;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:1902741,biological_process positive regulation of interferon-alpha secretion;GO:1904469,biological_process positive regulation of tumor necrosis factor secretion;GO:2000778,biological_process positive regulation of interleukin-6 secretion	DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.4.13]; K12646	DExD/H-box helicase 58 [Source:HGNC Symbol%3BAcc:HGNC:19102]
ENSG00000131368	35.65	35.26	39.98	33.37	36.23	28.42	0.193853829604702	4.45557497087037	0.0653529749448986	0.345791337592083	3:15042459-15065335:-	MRPS25	7;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S25 [Source:HGNC Symbol%3BAcc:HGNC:14511]
ENSG00000127804	11.86	10.51	12.32	13.47	11.82	14.51	-0.181976508654351	4.45349652520892	0.0654607317342241	0.346213916922422	17:2405561-2511891:-	METTL16	15;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0008168,molecular_function methyltransferase activity;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0016422,molecular_function mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030629,molecular_function U6 snRNA 3'-end binding;GO:0032259,biological_process methylation;GO:0035613,molecular_function RNA stem-loop binding;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0052907,molecular_function 23S rRNA (adenine(1618)-N(6))-methyltransferase activity;GO:0070475,biological_process rRNA base methylation;GO:0080009,biological_process mRNA methylation;GO:0120048,Molecular_Function U6 snRNA (adenine-(43)-N(6))-methyltransferase activity;GO:0120049,Biological_Process snRNA (adenine-N6)-methylation	NA	methyltransferase like 16 [Source:HGNC Symbol%3BAcc:HGNC:28484]
ENSG00000102390	38.90	40.09	38.08	35.58	38.11	32.29	0.154858644828014	4.91428570754075	0.0655280314600807	0.34642225490374	X:76172935-76178204:+	PBDC1	4;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process	NA	polysaccharide biosynthesis domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28790]
ENSG00000214279	1.93	1.61	1.58	1.48	1.26	1.39	0.325952574440697	2.29341663733732	0.0655665427199907	0.34647828641262	10:133453927-133523558:+	SCART1	10;GO:0002376,biological_process immune system process;GO:0002456,biological_process T cell mediated immunity;GO:0003674,molecular_function molecular_function;GO:0005044,molecular_function scavenger receptor activity;GO:0005737,cellular_component cytoplasm;GO:0005903,cellular_component brush border;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	scavenger receptor family member expressed on T-cells 1 [Source:HGNC Symbol%3BAcc:HGNC:32411]
ENSG00000204386	113.17	131.34	111.02	100.97	121.90	94.55	0.174352035254813	7.12652313542759	0.0657184936142919	0.347133472865619	6:31857658-31862906:-	NEU1	27;GO:0004308,molecular_function exo-alpha-sialidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006689,biological_process ganglioside catabolic process;GO:0008152,biological_process metabolic process;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035580,cellular_component specific granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0052794,molecular_function exo-alpha-(2->3)-sialidase activity;GO:0052795,molecular_function exo-alpha-(2->6)-sialidase activity;GO:0052796,molecular_function exo-alpha-(2->8)-sialidase activity;GO:0070062,cellular_component extracellular exosome	NEU1; sialidase-1 [EC:3.2.1.18]; K01186	neuraminidase 1 [Source:HGNC Symbol%3BAcc:HGNC:7758]
ENSG00000131732	15.12	16.10	14.67	19.16	15.11	19.63	-0.226242580986139	3.77565176698795	0.0658425162204797	0.347640643915276	5:81301589-81313297:+	ZCCHC9	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 9 [Source:HGNC Symbol%3BAcc:HGNC:25424]
ENSG00000068912	48.64	58.17	45.31	47.07	45.90	44.31	0.155991298075591	6.1277735680696	0.0659029294135964	0.347811676365209	2:53787043-53818819:+	ERLEC1	9;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0036503,biological_process ERAD pathway;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0051082,molecular_function unfolded protein binding;GO:0055085,biological_process transmembrane transport;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol	ERLEC1, XTP3B; endoplasmic reticulum lectin 1; K14008	endoplasmic reticulum lectin 1 [Source:HGNC Symbol%3BAcc:HGNC:25222]
ENSG00000167645	46.64	46.38	43.10	52.63	49.94	47.70	-0.131512077144309	5.66215875761964	0.0659810455149911	0.348075953241643	19:38305103-38317273:-	YIF1B	7;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030173,cellular_component integral component of Golgi membrane	NA	Yip1 interacting factor homolog B%2C membrane trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:30511]
ENSG00000183077	10.51	9.25	10.77	10.59	13.13	12.06	-0.210201347173707	3.78726653057875	0.0660674734513201	0.348285978767713	17:78187316-78207701:+	AFMID	8;GO:0004061,molecular_function arylformamidase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006569,biological_process tryptophan catabolic process;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019441,biological_process tryptophan catabolic process to kynurenine	AFMID; arylformamidase [EC:3.5.1.9]; K01432	arylformamidase [Source:HGNC Symbol%3BAcc:HGNC:20910]
ENSG00000167535	21.47	23.12	24.01	19.86	20.89	21.93	0.140171733932911	5.20042128064645	0.0660769741398506	0.348285978767713	12:48813793-48828941:+	CACNB3	26;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007528,biological_process neuromuscular junction development;GO:0008331,molecular_function high voltage-gated calcium channel activity;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019901,molecular_function protein kinase binding;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051899,biological_process membrane depolarization;GO:0060402,biological_process calcium ion transport into cytosol;GO:0061337,biological_process cardiac conduction;GO:0061577,biological_process calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070588,biological_process calcium ion transmembrane transport;GO:0072659,biological_process protein localization to plasma membrane;GO:0098903,biological_process regulation of membrane repolarization during action potential;GO:1901385,biological_process regulation of voltage-gated calcium channel activity;GO:1990454,cellular_component L-type voltage-gated calcium channel complex	CACNB3; voltage-dependent calcium channel beta-3; K04864	calcium voltage-gated channel auxiliary subunit beta 3 [Source:HGNC Symbol%3BAcc:HGNC:1403]
ENSG00000081014	2.02	2.40	2.19	2.93	2.73	2.31	-0.265113930953538	3.11189660257255	0.0661359784958188	0.348449024222665	15:50908671-51005900:+	AP4E1	11;GO:0005794,cellular_component Golgi apparatus;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030124,cellular_component AP-4 adaptor complex;GO:0031904,cellular_component endosome lumen;GO:0032588,cellular_component trans-Golgi network membrane	AP4E1; AP-4 complex subunit epsilon-1; K12400	adaptor related protein complex 4 epsilon 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:573]
ENSG00000091039	14.84	14.34	14.29	12.17	14.70	12.63	0.151637701434145	5.28679034441612	0.0661663315846636	0.348461041137221	12:76351796-76559809:-	OSBPL8	24;GO:0001786,molecular_function phosphatidylserine binding;GO:0005548,molecular_function phospholipid transporter activity;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0010891,biological_process negative regulation of sequestering of triglyceride;GO:0015485,molecular_function cholesterol binding;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030336,biological_process negative regulation of cell migration;GO:0031965,cellular_component nuclear membrane;GO:0032148,biological_process activation of protein kinase B activity;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0045444,biological_process fat cell differentiation;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0090204,biological_process protein localization to nuclear pore;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	NA	oxysterol binding protein like 8 [Source:HGNC Symbol%3BAcc:HGNC:16396]
ENSG00000100814	65.10	59.28	67.62	76.16	61.37	80.10	-0.167488135548459	6.07785640721476	0.0662493405085577	0.348745860150984	14:20311367-20333312:-	CCNB1IP1	14;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000795,cellular_component synaptonemal complex;GO:0001825,biological_process blastocyst formation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007286,biological_process spermatid development;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0051026,biological_process chiasma assembly;GO:0051321,biological_process meiotic cell cycle;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	cyclin B1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19437]
ENSG00000125351	13.37	12.84	13.85	14.17	14.68	16.14	-0.154195521380437	4.73251787333103	0.0662828495440016	0.348745860150984	X:119805310-119852998:-	UPF3B	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0031124,biological_process mRNA 3'-end processing;GO:0035145,cellular_component exon-exon junction complex;GO:0045727,biological_process positive regulation of translation;GO:0051028,biological_process mRNA transport	UPF3, RENT3; regulator of nonsense transcripts 3; K14328	UPF3B%2C regulator of nonsense mediated mRNA decay [Source:HGNC Symbol%3BAcc:HGNC:20439]
ENSG00000160767	15.29	15.20	14.08	13.45	13.73	13.55	0.140490533095034	4.93220809574157	0.0663046991022575	0.348745860150984	1:155247204-155255483:-	FAM189B	5;GO:0005515,molecular_function protein binding;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050699,molecular_function WW domain binding	NA	family with sequence similarity 189 member B [Source:HGNC Symbol%3BAcc:HGNC:1233]
ENSG00000106546	7.58	7.25	7.90	6.47	6.11	7.55	0.187163390317329	4.19742197047454	0.066413937837207	0.349172473686256	7:17298621-17346152:+	AHR	42;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0001223,molecular_function transcription coactivator binding;GO:0001568,biological_process blood vessel development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004874,molecular_function aryl hydrocarbon receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006805,biological_process xenobiotic metabolic process;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008134,molecular_function transcription factor binding;GO:0009410,biological_process response to xenobiotic stimulus;GO:0009636,biological_process response to toxic substance;GO:0010468,biological_process regulation of gene expression;GO:0017025,molecular_function TBP-class protein binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0030888,biological_process regulation of B cell proliferation;GO:0032922,biological_process circadian regulation of gene expression;GO:0034751,cellular_component aryl hydrocarbon receptor complex;GO:0034752,cellular_component cytosolic aryl hydrocarbon receptor complex;GO:0034753,cellular_component nuclear aryl hydrocarbon receptor complex;GO:0035326,molecular_function enhancer binding;GO:0043234,cellular_component protein complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0051879,molecular_function Hsp90 protein binding;GO:0070888,molecular_function E-box binding	AHR; aryl hydrocarbon receptor; K09093	aryl hydrocarbon receptor [Source:HGNC Symbol%3BAcc:HGNC:348]
ENSG00000144749	3.12	3.19	2.66	3.22	3.82	3.55	-0.232141995407647	3.47021843706265	0.0666515597146913	0.350273416908748	3:66378796-66501263:-	LRIG1	7;GO:0005886,cellular_component plasma membrane;GO:0007605,biological_process sensory perception of sound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022405,biological_process hair cycle process;GO:0032474,biological_process otolith morphogenesis;GO:0060384,biological_process innervation	NA	leucine rich repeats and immunoglobulin like domains 1 [Source:HGNC Symbol%3BAcc:HGNC:17360]
ENSG00000178234	20.06	22.12	19.61	18.36	20.29	17.28	0.152235867279115	5.21129253690702	0.0666861961367195	0.350307131885357	7:152025673-152122347:+	GALNT11	19;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005112,molecular_function Notch binding;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0007368,biological_process determination of left/right symmetry;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018243,biological_process protein O-linked glycosylation via threonine;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis;GO:0061314,biological_process Notch signaling involved in heart development	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 11 [Source:HGNC Symbol%3BAcc:HGNC:19875]
ENSG00000135476	4.64	6.04	4.62	5.78	7.13	5.13	-0.231239905170326	5.16049336878761	0.0667948627162916	0.350409034950702	12:53268298-53293643:+	ESPL1	24;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000212,biological_process meiotic spindle organization;GO:0000278,biological_process mitotic cell cycle;GO:0000910,biological_process cytokinesis;GO:0003824,molecular_function catalytic activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0007059,biological_process chromosome segregation;GO:0007127,biological_process meiosis I;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0040001,biological_process establishment of mitotic spindle localization;GO:0045143,biological_process homologous chromosome segregation;GO:0045842,biological_process positive regulation of mitotic metaphase/anaphase transition;GO:0045875,biological_process negative regulation of sister chromatid cohesion;GO:0051307,biological_process meiotic chromosome separation;GO:0072686,cellular_component mitotic spindle	ESP1; separase [EC:3.4.22.49]; K02365	extra spindle pole bodies like 1%2C separase [Source:HGNC Symbol%3BAcc:HGNC:16856]
ENSG00000025708	2.76	2.03	3.68	2.05	2.49	1.83	0.441186187190317	1.92047720210102	0.0668091144786338	0.350409034950702	22:50525751-50530056:-	TYMP	22;GO:0000002,biological_process mitochondrial genome maintenance;GO:0001525,biological_process angiogenesis;GO:0004645,molecular_function phosphorylase activity;GO:0005829,cellular_component cytosol;GO:0006206,biological_process pyrimidine nucleobase metabolic process;GO:0006213,biological_process pyrimidine nucleoside metabolic process;GO:0006935,biological_process chemotaxis;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0008152,biological_process metabolic process;GO:0009032,molecular_function thymidine phosphorylase activity;GO:0016154,molecular_function pyrimidine-nucleoside phosphorylase activity;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016763,molecular_function transferase activity, transferring pentosyl groups;GO:0030154,biological_process cell differentiation;GO:0031641,biological_process regulation of myelination;GO:0042803,molecular_function protein homodimerization activity;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0046135,biological_process pyrimidine nucleoside catabolic process;GO:0051969,biological_process regulation of transmission of nerve impulse;GO:1905333,biological_process regulation of gastric motility	deoA, TYMP; thymidine phosphorylase [EC:2.4.2.4]; K00758	thymidine phosphorylase [Source:HGNC Symbol%3BAcc:HGNC:3148]
ENSG00000217555	3.66	6.73	4.27	3.57	2.98	3.64	0.49527969662822	1.07462597535111	0.0668307211009639	0.350409034950702	16:66552562-66566251:+	CKLF	13;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0008009,molecular_function chemokine activity;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030593,biological_process neutrophil chemotaxis;GO:0030595,biological_process leukocyte chemotaxis;GO:0032940,biological_process secretion by cell;GO:0048246,biological_process macrophage chemotaxis;GO:0048247,biological_process lymphocyte chemotaxis	NA	chemokine like factor [Source:HGNC Symbol%3BAcc:HGNC:13253]
ENSG00000107338	22.89	21.53	23.67	22.85	18.58	20.03	0.162206306242509	5.05097624404864	0.0668552153709639	0.350409034950702	9:37919133-38069211:-	SHB	26;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001525,biological_process angiogenesis;GO:0001568,biological_process blood vessel development;GO:0001784,molecular_function phosphotyrosine binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0009967,biological_process positive regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0042100,biological_process B cell proliferation;GO:0045624,biological_process positive regulation of T-helper cell differentiation;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048514,biological_process blood vessel morphogenesis;GO:0050852,biological_process T cell receptor signaling pathway;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:1900194,biological_process negative regulation of oocyte maturation	NA	SH2 domain containing adaptor protein B [Source:HGNC Symbol%3BAcc:HGNC:10838]
ENSG00000174106	6.43	7.38	7.41	6.60	6.60	5.38	0.201345771709266	4.18808127215407	0.0668944590655431	0.350409034950702	12:65169570-65248327:+	LEMD3	18;GO:0001525,biological_process angiogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0006997,biological_process nucleus organization;GO:0006998,biological_process nuclear envelope organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0031490,molecular_function chromatin DNA binding;GO:0031965,cellular_component nuclear membrane;GO:0032926,biological_process negative regulation of activin receptor signaling pathway;GO:0070197,biological_process meiotic attachment of telomere to nuclear envelope;GO:1902531,biological_process regulation of intracellular signal transduction	NA	LEM domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28887]
ENSG00000188021	13.32	13.12	13.25	11.32	12.11	12.55	0.153036070569306	4.57059553671303	0.0669006158361162	0.350409034950702	X:56563638-56567868:+	UBQLN2	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:1900186,biological_process negative regulation of clathrin-mediated endocytosis;GO:1903071,biological_process positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1904021,biological_process negative regulation of G-protein coupled receptor internalization;GO:2000785,biological_process regulation of autophagosome assembly	UBQLN, DSK2; ubiquilin; K04523	ubiquilin 2 [Source:HGNC Symbol%3BAcc:HGNC:12509]
ENSG00000164167	42.08	27.48	30.67	41.18	36.97	46.59	-0.292159349161556	3.20816317646429	0.0669035949499178	0.350409034950702	4:146175684-146200000:+	LSM6	22;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005688,cellular_component U6 snRNP;GO:0005730,cellular_component nucleolus;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0008033,biological_process tRNA processing;GO:0008380,biological_process RNA splicing;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0070062,cellular_component extracellular exosome	LSM6; U6 snRNA-associated Sm-like protein LSm6; K12625	LSM6 homolog%2C U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol%3BAcc:HGNC:17017]
ENSG00000116205	3.65	4.16	4.20	5.83	5.01	4.27	-0.322397044994211	2.36277870794298	0.0669562823633469	0.350409034950702	1:54053586-54112519:+	TCEANC2	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated	NA	transcription elongation factor A N-terminal and central domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26494]
ENSG00000110852	29.76	23.04	34.10	25.43	22.42	25.95	0.257701822102378	3.69995821843023	0.066959657689766	0.350409034950702	12:9852983-9870136:-	CLEC2B	6;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0050776,biological_process regulation of immune response	CLEC2B; C-type lectin domain family 2 member B; K10071	C-type lectin domain family 2 member B [Source:HGNC Symbol%3BAcc:HGNC:2053]
ENSG00000060491	47.77	39.49	45.91	54.70	43.12	53.35	-0.16966722450304	6.73869323658871	0.0671527238199407	0.35127128562028	20:62804834-62814000:+	OGFR	10;GO:0001558,biological_process regulation of cell growth;GO:0004872,molecular_function receptor activity;GO:0004985,molecular_function opioid receptor activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0038003,biological_process opioid receptor signaling pathway;GO:0040008,biological_process regulation of growth	NA	opioid growth factor receptor [Source:HGNC Symbol%3BAcc:HGNC:15768]
ENSG00000115884	94.92	107.48	93.74	88.91	96.10	86.33	0.135946982162096	6.65847713044516	0.0672038112441281	0.351298690313775	2:20200796-20225433:-	SDC1	35;GO:0001523,biological_process retinoid metabolic process;GO:0001657,biological_process ureteric bud development;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0006954,biological_process inflammatory response;GO:0008022,molecular_function protein C-terminus binding;GO:0009636,biological_process response to toxic substance;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0042060,biological_process wound healing;GO:0042476,biological_process odontogenesis;GO:0042542,biological_process response to hydrogen peroxide;GO:0043202,cellular_component lysosomal lumen;GO:0043234,cellular_component protein complex;GO:0048627,biological_process myoblast development;GO:0050900,biological_process leukocyte migration;GO:0051384,biological_process response to glucocorticoid;GO:0051591,biological_process response to cAMP;GO:0051592,biological_process response to calcium ion;GO:0055002,biological_process striated muscle cell development;GO:0060009,biological_process Sertoli cell development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903553,biological_process positive regulation of extracellular exosome assembly	SDC1, CD138; syndecan 1; K06257	syndecan 1 [Source:HGNC Symbol%3BAcc:HGNC:10658]
ENSG00000153234	0.67	1.07	0.49	0.33	0.47	0.59	0.641236093048138	0.268465266219479	0.0672604290481419	0.351298690313775	2:156324431-156342348:-	NR4A2	59;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001666,biological_process response to hypoxia;GO:0001764,biological_process neuron migration;GO:0001975,biological_process response to amphetamine;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008013,molecular_function beta-catenin binding;GO:0008270,molecular_function zinc ion binding;GO:0008344,biological_process adult locomotory behavior;GO:0009791,biological_process post-embryonic development;GO:0010467,biological_process gene expression;GO:0010468,biological_process regulation of gene expression;GO:0016607,cellular_component nuclear speck;GO:0021952,biological_process central nervous system projection neuron axonogenesis;GO:0021953,biological_process central nervous system neuron differentiation;GO:0021986,biological_process habenula development;GO:0030182,biological_process neuron differentiation;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0034599,biological_process cellular response to oxidative stress;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0042053,biological_process regulation of dopamine metabolic process;GO:0042416,biological_process dopamine biosynthetic process;GO:0042417,biological_process dopamine metabolic process;GO:0042551,biological_process neuron maturation;GO:0042803,molecular_function protein homodimerization activity;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043576,biological_process regulation of respiratory gaseous exchange;GO:0045444,biological_process fat cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051866,biological_process general adaptation syndrome;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0071376,biological_process cellular response to corticotropin-releasing hormone stimulus;GO:0071542,biological_process dopaminergic neuron differentiation;GO:1904948,biological_process midbrain dopaminergic neuron differentiation;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	NA	nuclear receptor subfamily 4 group A member 2 [Source:HGNC Symbol%3BAcc:HGNC:7981]
ENSG00000049239	14.18	14.06	14.04	12.85	12.83	13.21	0.131966374491045	5.03145194698809	0.0673041080425377	0.351298690313775	1:9234774-9271337:+	H6PD	20;GO:0003824,molecular_function catalytic activity;GO:0004345,molecular_function glucose-6-phosphate dehydrogenase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0006739,biological_process NADP metabolic process;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016787,molecular_function hydrolase activity;GO:0017057,molecular_function 6-phosphogluconolactonase activity;GO:0030246,molecular_function carbohydrate binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0047936,molecular_function glucose 1-dehydrogenase [NAD(P)] activity;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process;GO:0097305,biological_process response to alcohol	H6PD; hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]; K13937	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:4795]
ENSG00000103037	6.82	5.80	6.95	7.69	7.38	8.00	-0.215636110129314	3.39480075158474	0.0673197617956061	0.351298690313775	16:58515478-58521181:+	SETD6	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0019827,biological_process stem cell population maintenance;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0048863,biological_process stem cell differentiation;GO:0050727,biological_process regulation of inflammatory response;GO:0051059,molecular_function NF-kappaB binding	NA	SET domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:26116]
ENSG00000153560	26.77	23.51	23.52	27.94	27.36	26.61	-0.135243131586341	5.47020235142277	0.0673557395024418	0.351298690313775	3:33388335-33441371:-	UBP1	13;GO:0001525,biological_process angiogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0019079,biological_process viral genome replication;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	upstream binding protein 1 (LBP-1a) [Source:HGNC Symbol%3BAcc:HGNC:12507]
ENSG00000070669	204.18	146.89	199.88	235.04	183.46	224.08	-0.209815936633941	8.44728478427584	0.0673598399342295	0.351298690313775	7:97852117-97872542:-	ASNS	26;GO:0000166,molecular_function nucleotide binding;GO:0001889,biological_process liver development;GO:0004066,molecular_function asparagine synthase (glutamine-hydrolyzing) activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006529,biological_process asparagine biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009416,biological_process response to light stimulus;GO:0009612,biological_process response to mechanical stimulus;GO:0009636,biological_process response to toxic substance;GO:0016874,molecular_function ligase activity;GO:0031427,biological_process response to methotrexate;GO:0031667,biological_process response to nutrient levels;GO:0032354,biological_process response to follicle-stimulating hormone;GO:0032870,biological_process cellular response to hormone stimulus;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0042149,biological_process cellular response to glucose starvation;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043200,biological_process response to amino acid;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0048037,molecular_function cofactor binding;GO:0070981,biological_process L-asparagine biosynthetic process	asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]; K01953	asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol%3BAcc:HGNC:753]
ENSG00000135617	6.89	6.78	4.83	3.32	6.05	4.24	0.449346455937639	1.65280119887707	0.0674277793267328	0.351298690313775	2:73228005-73233238:-	PRADC1	3;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0070062,cellular_component extracellular exosome	NA	protease associated domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16047]
ENSG00000079819	78.95	72.14	76.16	80.47	82.91	84.14	-0.110841703207243	8.06038818150969	0.0674425222678961	0.351298690313775	6:130839346-131063322:-	EPB41L2	31;GO:0001558,biological_process regulation of cell growth;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0007010,biological_process cytoskeleton organization;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007049,biological_process cell cycle;GO:0008091,cellular_component spectrin;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008180,cellular_component COP9 signalosome;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030507,molecular_function spectrin binding;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031032,biological_process actomyosin structure organization;GO:0042731,molecular_function PH domain binding;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0099738,cellular_component cell cortex region;GO:1904778,biological_process positive regulation of protein localization to cell cortex	NA	erythrocyte membrane protein band 4.1 like 2 [Source:HGNC Symbol%3BAcc:HGNC:3379]
ENSG00000088448	29.98	26.76	29.05	25.38	26.89	26.75	0.134378203654542	5.41240104655479	0.0674467372329827	0.351298690313775	13:110878539-110915069:-	ANKRD10	2;GO:0005515,molecular_function protein binding;GO:0060828,biological_process regulation of canonical Wnt signaling pathway	NA	ankyrin repeat domain 10 [Source:HGNC Symbol%3BAcc:HGNC:20265]
ENSG00000103160	12.91	15.06	14.20	15.43	15.70	17.33	-0.197420670616572	3.91759788585618	0.0674823091681032	0.351298690313775	16:84122145-84145192:-	HSDL1	1;GO:0005739,cellular_component mitochondrion	NA	hydroxysteroid dehydrogenase like 1 [Source:HGNC Symbol%3BAcc:HGNC:16475]
ENSG00000011295	29.79	29.57	34.34	36.80	32.15	35.91	-0.148887497140875	5.54753302850892	0.067483701309322	0.351298690313775	17:15999379-16045015:+	TTC19	13;GO:0000910,biological_process cytokinesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0030496,cellular_component midbody;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly;GO:0051301,biological_process cell division	NA	tetratricopeptide repeat domain 19 [Source:HGNC Symbol%3BAcc:HGNC:26006]
ENSG00000170473	13.54	12.38	12.12	13.76	14.39	15.81	-0.195558640393807	3.78772799933644	0.0674975732214898	0.351298690313775	12:55901412-55932618:-	PYM1	14;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0030054,cellular_component cell junction;GO:0035145,cellular_component exon-exon junction complex;GO:0043022,molecular_function ribosome binding;GO:0045727,biological_process positive regulation of translation;GO:1903259,biological_process exon-exon junction complex disassembly	WIBG, PYM; partner of Y14 and mago; K14294	PYM homolog 1%2C exon junction complex associated factor [Source:HGNC Symbol%3BAcc:HGNC:30258]
ENSG00000151498	13.84	16.04	15.49	13.41	14.19	12.65	0.179831420011768	4.1592835197346	0.0676068391071671	0.351611613440119	11:134253494-134265855:+	ACAD8	13;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006574,biological_process valine catabolic process;GO:0006629,biological_process lipid metabolic process;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	ACAD8; isobutyryl-CoA dehydrogenase [EC:1.3.99.-]; K11538	acyl-CoA dehydrogenase family member 8 [Source:HGNC Symbol%3BAcc:HGNC:87]
ENSG00000121274	5.25	4.39	5.82	6.10	6.11	6.03	-0.213620990290077	3.59482897709919	0.067614349575571	0.351611613440119	16:50152917-50235310:+	PAPD5	20;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0004652,molecular_function polynucleotide adenylyltransferase activity;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0043630,biological_process ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0070034,molecular_function telomerase RNA binding;GO:0071044,biological_process histone mRNA catabolic process;GO:0071897,biological_process DNA biosynthetic process	NA	poly(A) RNA polymerase D5%2C non-canonical [Source:HGNC Symbol%3BAcc:HGNC:30758]
ENSG00000172890	27.98	27.55	28.22	25.43	26.05	26.52	0.114749017348815	6.00351493193627	0.0676673206757624	0.351627907920227	11:71453108-71524107:+	NADSYN1	12;GO:0000166,molecular_function nucleotide binding;GO:0003952,molecular_function NAD+ synthase (glutamine-hydrolyzing) activity;GO:0004359,molecular_function glutaminase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006807,biological_process nitrogen compound metabolic process;GO:0009435,biological_process NAD biosynthetic process;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016874,molecular_function ligase activity;GO:0019674,biological_process NAD metabolic process	E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]; K01950	NAD synthetase 1 [Source:HGNC Symbol%3BAcc:HGNC:29832]
ENSG00000132463	77.06	67.07	72.37	81.13	75.54	81.75	-0.12577492733832	7.04219041159024	0.067693746363301	0.351627907920227	4:70815781-70839945:-	GRSF1	13;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006378,biological_process mRNA polyadenylation;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008033,biological_process tRNA processing;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0035770,cellular_component ribonucleoprotein granule;GO:0042645,cellular_component mitochondrial nucleoid	NA	G-rich RNA sequence binding factor 1 [Source:HGNC Symbol%3BAcc:HGNC:4610]
ENSG00000154678	2.63	1.41	2.35	1.90	1.30	1.64	0.429096820772429	2.2569397969442	0.0677200293210971	0.351627907920227	7:31751178-32299329:-	PDE1C	10;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004117,molecular_function calmodulin-dependent cyclic-nucleotide phosphodiesterase activity;GO:0005516,molecular_function calmodulin binding;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0007165,biological_process signal transduction;GO:0007608,biological_process sensory perception of smell;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]; K13755	phosphodiesterase 1C [Source:HGNC Symbol%3BAcc:HGNC:8776]
ENSG00000105197	27.90	29.33	25.77	31.12	31.09	29.55	-0.136009011124181	5.50528622769045	0.067730792543081	0.351627907920227	19:39480411-39493785:+	TIMM50	22;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0003723,molecular_function RNA binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005134,molecular_function interleukin-2 receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0006470,biological_process protein dephosphorylation;GO:0006810,biological_process transport;GO:0007006,biological_process mitochondrial membrane organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043021,molecular_function ribonucleoprotein complex binding	NA	translocase of inner mitochondrial membrane 50 [Source:HGNC Symbol%3BAcc:HGNC:23656]
ENSG00000185345	0.51	0.53	0.81	0.99	0.75	1.05	-0.573758321942709	0.650585096742717	0.067782477680086	0.351718204455926	6:161347419-162727771:-	PRKN	158;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0000266,biological_process mitochondrial fission;GO:0000422,biological_process mitophagy;GO:0000423,biological_process macromitophagy;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001963,biological_process synaptic transmission, dopaminergic;GO:0001964,biological_process startle response;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006513,biological_process protein monoubiquitination;GO:0006914,biological_process autophagy;GO:0006979,biological_process response to oxidative stress;GO:0007005,biological_process mitochondrion organization;GO:0007417,biological_process central nervous system development;GO:0007612,biological_process learning;GO:0007626,biological_process locomotory behavior;GO:0008013,molecular_function beta-catenin binding;GO:0008270,molecular_function zinc ion binding;GO:0008344,biological_process adult locomotory behavior;GO:0010498,biological_process proteasomal protein catabolic process;GO:0010506,biological_process regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010636,biological_process positive regulation of mitochondrial fusion;GO:0010637,biological_process negative regulation of mitochondrial fusion;GO:0010821,biological_process regulation of mitochondrion organization;GO:0010906,biological_process regulation of glucose metabolic process;GO:0010994,biological_process free ubiquitin chain polymerization;GO:0014059,biological_process regulation of dopamine secretion;GO:0015631,molecular_function tubulin binding;GO:0016235,cellular_component aggresome;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019538,biological_process protein metabolic process;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0030165,molecular_function PDZ domain binding;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030544,molecular_function Hsp70 protein binding;GO:0031072,molecular_function heat shock protein binding;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0031648,biological_process protein destabilization;GO:0032092,biological_process positive regulation of protein binding;GO:0032232,biological_process negative regulation of actin filament bundle assembly;GO:0032368,biological_process regulation of lipid transport;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033132,biological_process negative regulation of glucokinase activity;GO:0034620,biological_process cellular response to unfolded protein;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035519,biological_process protein K29-linked ubiquitination;GO:0036503,biological_process ERAD pathway;GO:0042053,biological_process regulation of dopamine metabolic process;GO:0042415,biological_process norepinephrine metabolic process;GO:0042417,biological_process dopamine metabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043005,cellular_component neuron projection;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0043274,molecular_function phospholipase binding;GO:0043388,biological_process positive regulation of DNA binding;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044257,biological_process cellular protein catabolic process;GO:0044267,biological_process cellular protein metabolic process;GO:0044314,biological_process protein K27-linked ubiquitination;GO:0044828,biological_process negative regulation by host of viral genome replication;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046872,molecular_function metal ion binding;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050804,biological_process modulation of synaptic transmission;GO:0050821,biological_process protein stabilization;GO:0051087,molecular_function chaperone binding;GO:0051582,biological_process positive regulation of neurotransmitter uptake;GO:0051583,biological_process dopamine uptake involved in synaptic transmission;GO:0051865,biological_process protein autoubiquitination;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055069,biological_process zinc ion homeostasis;GO:0060548,biological_process negative regulation of cell death;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061734,biological_process parkin-mediated mitophagy in response to mitochondrial depolarization;GO:0070050,biological_process neuron cellular homeostasis;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070585,biological_process protein localization to mitochondrion;GO:0070842,biological_process aggresome assembly;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0071287,biological_process cellular response to manganese ion;GO:0071797,cellular_component LUBAC complex;GO:0085020,biological_process protein K6-linked ubiquitination;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097237,biological_process cellular response to toxic substance;GO:0097413,cellular_component Lewy body;GO:0097602,molecular_function cullin family protein binding;GO:0098779,biological_process mitophagy in response to mitochondrial depolarization;GO:0098793,cellular_component presynapse;GO:0099073,cellular_component mitochondrion-derived vesicle;GO:0099074,biological_process mitochondrion to lysosome transport;GO:1900407,biological_process regulation of cellular response to oxidative stress;GO:1901215,biological_process negative regulation of neuron death;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902254,biological_process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:1902283,biological_process negative regulation of primary amine oxidase activity;GO:1902530,biological_process positive regulation of protein linear polyubiquitination;GO:1902803,biological_process regulation of synaptic vesicle transport;GO:1903202,biological_process negative regulation of oxidative stress-induced cell death;GO:1903214,biological_process regulation of protein targeting to mitochondrion;GO:1903265,biological_process positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1903351,biological_process cellular response to dopamine;GO:1903377,biological_process negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903378,biological_process positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903382,biological_process negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903542,biological_process negative regulation of exosomal secretion;GO:1903599,biological_process positive regulation of mitophagy;GO:1903861,biological_process positive regulation of dendrite extension;GO:1904049,biological_process negative regulation of spontaneous neurotransmitter secretion;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1905281,biological_process positive regulation of retrograde transport, endosome to Golgi;GO:1905366,biological_process negative regulation of intralumenal vesicle formation;GO:1905477,biological_process positive regulation of protein localization to membrane;GO:1990381,molecular_function ubiquitin-specific protease binding;GO:1990444,molecular_function F-box domain binding;GO:1990452,cellular_component Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:2000377,biological_process regulation of reactive oxygen species metabolic process;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	PARK2; parkin [EC:2.3.2.31]; K04556	parkin RBR E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:8607]
ENSG00000054392	4.79	3.52	4.55	4.99	5.19	5.40	-0.247011189774405	3.03371516526396	0.067804854850804	0.351718204455926	1:210328251-210676296:+	HHAT	14;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008374,molecular_function O-acyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	hedgehog acyltransferase [Source:HGNC Symbol%3BAcc:HGNC:18270]
ENSG00000166507	1.58	1.09	1.40	1.02	1.25	0.85	0.417864154639221	1.77897195050717	0.0678652375065196	0.351772961421414	10:73801910-73811798:-	NDST2	14;GO:0000139,cellular_component Golgi membrane;GO:0003824,molecular_function catalytic activity;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0008146,molecular_function sulfotransferase activity;GO:0008152,biological_process metabolic process;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0015016,molecular_function [heparan sulfate]-glucosamine N-sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0030210,biological_process heparin biosynthetic process;GO:0050119,molecular_function N-acetylglucosamine deacetylase activity	NDST2; heparan sulfate N-deacetylase/N-sulfotransferase NDST2 [EC:3.1.1.- 2.8.2.-]; K02577	N-deacetylase and N-sulfotransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:7681]
ENSG00000087087	30.94	35.77	30.95	31.05	29.36	29.14	0.133700691342794	6.44635879608138	0.0678720891488186	0.351772961421414	7:100875110-100888664:+	SRRT	18;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008283,biological_process cell proliferation;GO:0031047,biological_process gene silencing by RNA;GO:0031053,biological_process primary miRNA processing;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043234,cellular_component protein complex;GO:0046685,biological_process response to arsenic-containing substance;GO:0050769,biological_process positive regulation of neurogenesis;GO:0097150,biological_process neuronal stem cell population maintenance	NA	serrate%2C RNA effector molecule [Source:HGNC Symbol%3BAcc:HGNC:24101]
ENSG00000068394	18.30	18.94	16.70	20.61	19.01	20.78	-0.155878189522969	4.77507893067521	0.0679035235149891	0.351788997241886	X:49113388-49123801:-	GPKOW	7;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008150,biological_process biological_process	NA	G-patch domain and KOW motifs [Source:HGNC Symbol%3BAcc:HGNC:30677]
ENSG00000151491	26.61	24.96	26.95	27.33	29.16	29.68	-0.120367356207147	6.08615520264317	0.0679366694929891	0.351813883361065	12:15620157-15882329:-	EPS8	38;GO:0003779,molecular_function actin binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005938,cellular_component cell cortex;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0008283,biological_process cell proliferation;GO:0008344,biological_process adult locomotory behavior;GO:0008360,biological_process regulation of cell shape;GO:0009967,biological_process positive regulation of signal transduction;GO:0010458,biological_process exit from mitosis;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016601,biological_process Rac protein signal transduction;GO:0017146,cellular_component NMDA selective glutamate receptor complex;GO:0030054,cellular_component cell junction;GO:0030426,cellular_component growth cone;GO:0030832,biological_process regulation of actin filament length;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031982,cellular_component vesicle;GO:0032420,cellular_component stereocilium;GO:0032587,cellular_component ruffle membrane;GO:0035591,molecular_function signaling adaptor activity;GO:0036336,biological_process dendritic cell migration;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0048149,biological_process behavioral response to ethanol;GO:0048365,molecular_function Rac GTPase binding;GO:0051016,biological_process barbed-end actin filament capping;GO:0051017,biological_process actin filament bundle assembly;GO:0051764,biological_process actin crosslink formation;GO:0070062,cellular_component extracellular exosome;GO:0070358,biological_process actin polymerization-dependent cell motility;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	epidermal growth factor receptor pathway substrate 8 [Source:HGNC Symbol%3BAcc:HGNC:3420]
ENSG00000174842	7.58	9.32	8.06	8.93	10.20	9.57	-0.200361497718552	4.04869328391522	0.0680168905938319	0.351822625400102	1:92246401-92298987:-	GLMN	21;GO:0001570,biological_process vasculogenesis;GO:0001843,biological_process neural tube closure;GO:0005171,molecular_function hepatocyte growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042692,biological_process muscle cell differentiation;GO:0045086,biological_process positive regulation of interleukin-2 biosynthetic process;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0055105,molecular_function ubiquitin-protein transferase inhibitor activity;GO:0072359,biological_process circulatory system development	NA	glomulin%2C FKBP associated protein [Source:HGNC Symbol%3BAcc:HGNC:14373]
ENSG00000187010	1.25	1.58	1.53	1.42	0.65	0.99	0.511063779829399	1.1076994055667	0.0680854105546863	0.351822625400102	1:25272392-25330445:+	RHD	8;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008519,molecular_function ammonium transmembrane transporter activity;GO:0015695,biological_process organic cation transport;GO:0015696,biological_process ammonium transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0072488,biological_process ammonium transmembrane transport	NA	Rh blood group D antigen [Source:HGNC Symbol%3BAcc:HGNC:10009]
ENSG00000114982	20.47	19.48	20.47	23.55	21.80	21.11	-0.123647711865302	5.93597476708624	0.0680883392123021	0.351822625400102	2:96593169-96642787:-	KANSL3	12;GO:0000123,cellular_component histone acetyltransferase complex;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0016569,biological_process covalent chromatin modification;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific)	NA	KAT8 regulatory NSL complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:25473]
ENSG00000101577	15.47	16.25	16.20	14.93	14.77	14.57	0.124742991553174	5.43105945976161	0.0680903117391586	0.351822625400102	18:2916993-3013315:-	LPIN2	19;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0009062,biological_process fatty acid catabolic process;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0019432,biological_process triglyceride biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]; K15728	lipin 2 [Source:HGNC Symbol%3BAcc:HGNC:14450]
ENSG00000168803	8.98	9.13	9.42	8.78	8.21	6.21	0.262405924284565	3.24821136920546	0.0681310214567771	0.351822625400102	15:43330673-43354555:+	ADAL	10;GO:0004000,molecular_function adenosine deaminase activity;GO:0005829,cellular_component cytosol;GO:0006154,biological_process adenosine catabolic process;GO:0009117,biological_process nucleotide metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0017144,biological_process drug metabolic process;GO:0019239,molecular_function deaminase activity;GO:0043101,biological_process purine-containing compound salvage;GO:0046103,biological_process inosine biosynthetic process;GO:0046872,molecular_function metal ion binding	NA	adenosine deaminase like [Source:HGNC Symbol%3BAcc:HGNC:31853]
ENSG00000138835	13.39	10.90	12.15	14.93	12.27	13.92	-0.159205535234099	5.80057159424423	0.0681418413456836	0.351822625400102	9:113444730-113597743:+	RGS3	12;GO:0000188,biological_process inactivation of MAPK activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity	RGS3; regulator of G-protein signalling 3; K07524	regulator of G protein signaling 3 [Source:HGNC Symbol%3BAcc:HGNC:9999]
ENSG00000133026	25.28	29.11	24.18	27.44	29.75	30.05	-0.141008998361831	7.37991814090581	0.0682118676428755	0.351822625400102	17:8474204-8630761:-	MYH10	30;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0000281,biological_process mitotic cytokinesis;GO:0001725,cellular_component stress fiber;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005938,cellular_component cell cortex;GO:0007155,biological_process cell adhesion;GO:0008360,biological_process regulation of cell shape;GO:0016459,cellular_component myosin complex;GO:0016460,cellular_component myosin II complex;GO:0016887,molecular_function ATPase activity;GO:0030027,cellular_component lamellipodium;GO:0030048,biological_process actin filament-based movement;GO:0030496,cellular_component midbody;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0031032,biological_process actomyosin structure organization;GO:0032154,cellular_component cleavage furrow;GO:0042641,cellular_component actomyosin;GO:0042995,cellular_component cell projection;GO:0043531,molecular_function ADP binding;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome;GO:0097513,cellular_component myosin II filament	MYH; myosin heavy chain; K10352	myosin heavy chain 10 [Source:HGNC Symbol%3BAcc:HGNC:7568]
ENSG00000175505	28.46	32.42	26.28	26.18	27.53	22.50	0.200011287946857	4.20533824411343	0.068219188756751	0.351822625400102	11:67364167-67374177:-	CLCF1	23;GO:0002639,biological_process positive regulation of immunoglobulin production;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005127,molecular_function ciliary neurotrophic factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007259,biological_process JAK-STAT cascade;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030183,biological_process B cell differentiation;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0048295,biological_process positive regulation of isotype switching to IgE isotypes;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0070062,cellular_component extracellular exosome;GO:0097058,cellular_component CRLF-CLCF1 complex;GO:0097059,cellular_component CNTFR-CLCF1 complex	BSF3, CLC; B-cell stimulating factor 3; K05421	cardiotrophin like cytokine factor 1 [Source:HGNC Symbol%3BAcc:HGNC:17412]
ENSG00000137767	39.76	37.31	38.17	37.06	33.09	36.22	0.128698763306201	5.69358732108827	0.068219828896211	0.351822625400102	15:45631147-45691294:+	SQOR	8;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0048038,molecular_function quinone binding;GO:0055114,biological_process oxidation-reduction process;GO:0070221,biological_process sulfide oxidation, using sulfide:quinone oxidoreductase;GO:0070224,molecular_function sulfide:quinone oxidoreductase activity;GO:0070813,biological_process hydrogen sulfide metabolic process	sqr; sulfide:quinone oxidoreductase [EC:1.8.5.4]; K17218	sulfide quinone oxidoreductase [Source:HGNC Symbol%3BAcc:HGNC:20390]
ENSG00000272398	3271.88	3362.12	3458.31	3109.53	3246.41	3102.08	0.105430410119181	11.3183125442296	0.0682408489924898	0.351822625400102	6:106969830-106975627:-	CD24	1;GO:0007155,biological_process cell adhesion	CD24; CD24 antigen; K06469	CD24 molecule [Source:HGNC Symbol%3BAcc:HGNC:1645]
ENSG00000186765	1.23	1.30	2.00	0.77	1.18	1.23	0.526080802941975	1.09813076749964	0.0682501314721217	0.351822625400102	17:81528395-81537130:+	FSCN2	18;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007601,biological_process visual perception;GO:0009653,biological_process anatomical structure morphogenesis;GO:0015629,cellular_component actin cytoskeleton;GO:0016477,biological_process cell migration;GO:0030036,biological_process actin cytoskeleton organization;GO:0030674,molecular_function protein binding, bridging;GO:0031941,cellular_component filamentous actin;GO:0032403,molecular_function protein complex binding;GO:0032420,cellular_component stereocilium;GO:0042462,biological_process eye photoreceptor cell development;GO:0042995,cellular_component cell projection;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly	NA	fascin actin-bundling protein 2%2C retinal [Source:HGNC Symbol%3BAcc:HGNC:3960]
ENSG00000198604	14.22	14.32	15.25	12.99	14.37	13.11	0.126322426286142	6.083990477786	0.0683346574743429	0.352026389578221	14:34752730-34875647:-	BAZ1A	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008623,cellular_component CHRAC;GO:0016590,cellular_component ACF complex;GO:0046872,molecular_function metal ion binding	NA	bromodomain adjacent to zinc finger domain 1A [Source:HGNC Symbol%3BAcc:HGNC:960]
ENSG00000178127	128.04	124.82	123.59	139.13	135.69	135.45	-0.112169341289658	6.85668834043181	0.0683463787064782	0.352026389578221	18:9102629-9134345:+	NDUFV2	19;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0007399,biological_process nervous system development;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0043209,cellular_component myelin sheath;GO:0046872,molecular_function metal ion binding;GO:0048738,biological_process cardiac muscle tissue development;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2 1.6.99.3]; K03943	NADH:ubiquinone oxidoreductase core subunit V2 [Source:HGNC Symbol%3BAcc:HGNC:7717]
ENSG00000178809	2.33	2.14	3.30	2.12	1.52	1.91	0.508270254205952	1.0280274766731	0.0683908464640904	0.352109322753527	7:75395062-75410996:+	TRIM73	4;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 73 [Source:HGNC Symbol%3BAcc:HGNC:18162]
ENSG00000107317	1.37	0.35	1.78	1.00	0.28	0.68	0.891252764667852	-0.11397488708133	0.0684756361845334	0.352292793833092	9:136975091-136981742:+	PTGDS	27;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0004667,molecular_function prostaglandin-D synthase activity;GO:0005215,molecular_function transporter activity;GO:0005501,molecular_function retinoid binding;GO:0005504,molecular_function fatty acid binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0019371,biological_process cyclooxygenase pathway;GO:0031965,cellular_component nuclear membrane;GO:0036094,molecular_function small molecule binding;GO:0045187,biological_process regulation of circadian sleep/wake cycle, sleep;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	PTGDS; prostaglandin-H2 D-isomerase [EC:5.3.99.2]; K01830	prostaglandin D2 synthase [Source:HGNC Symbol%3BAcc:HGNC:9592]
ENSG00000163808	7.25	7.54	6.03	7.38	8.32	7.85	-0.170744464760243	4.96717159811068	0.0684832443018812	0.352292793833092	3:44761716-44873376:+	KIF15	21;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005873,cellular_component plus-end kinesin complex;GO:0005874,cellular_component microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II	NA	kinesin family member 15 [Source:HGNC Symbol%3BAcc:HGNC:17273]
ENSG00000109606	80.10	90.28	77.61	86.74	97.08	90.57	-0.135292037131208	7.69940929681291	0.0685565356113211	0.352523726819938	4:24517440-24584550:-	DHX15	22;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0003725,molecular_function double-stranded RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0009636,biological_process response to toxic substance;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0043279,biological_process response to alkaloid;GO:0071008,cellular_component U2-type post-mRNA release spliceosomal complex	DHX15, PRP43; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 [EC:3.6.4.13]; K12820	DEAH-box helicase 15 [Source:HGNC Symbol%3BAcc:HGNC:2738]
ENSG00000111664	4.44	4.53	6.41	3.41	3.96	4.70	0.365456632491858	2.28941126556776	0.0686862504087963	0.353044482950057	12:6839953-6847393:+	GNB3	16;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008217,biological_process regulation of blood pressure;GO:0030425,cellular_component dendrite;GO:0030507,molecular_function spectrin binding;GO:0043005,cellular_component neuron projection;GO:0044297,cellular_component cell body;GO:0051020,molecular_function GTPase binding;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus	GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; K07825	G protein subunit beta 3 [Source:HGNC Symbol%3BAcc:HGNC:4400]
ENSG00000067365	17.48	15.23	15.99	20.75	16.63	18.30	-0.177477951247913	4.63795152270206	0.0687653637912738	0.353184675967356	16:8621682-8649654:+	METTL22	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0031072,molecular_function heat shock protein binding;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex	NA	methyltransferase like 22 [Source:HGNC Symbol%3BAcc:HGNC:28368]
ENSG00000107611	0.32	0.36	0.32	0.18	0.21	0.34	0.42936711989525	1.7146331272697	0.068770431145823	0.353184675967356	10:16823963-17129831:-	CUBN	39;GO:0001894,biological_process tissue homeostasis;GO:0004872,molecular_function receptor activity;GO:0005215,molecular_function transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005905,cellular_component clathrin-coated pit;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0009235,biological_process cobalamin metabolic process;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0015889,biological_process cobalamin transport;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030139,cellular_component endocytic vesicle;GO:0031232,cellular_component extrinsic component of external side of plasma membrane;GO:0031419,molecular_function cobalamin binding;GO:0031526,cellular_component brush border membrane;GO:0034384,biological_process high-density lipoprotein particle clearance;GO:0042359,biological_process vitamin D metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0042953,biological_process lipoprotein transport;GO:0043202,cellular_component lysosomal lumen;GO:0045177,cellular_component apical part of cell;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	CUBN; cubilin; K14616	cubilin [Source:HGNC Symbol%3BAcc:HGNC:2548]
ENSG00000137267	10.90	13.82	9.81	12.34	16.30	12.75	-0.258240846804016	4.0864508504384	0.0688701113166462	0.353550327449764	6:3153668-3157526:-	TUBB2A	14;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	TUBB; tubulin beta; K07375	tubulin beta 2A class IIa [Source:HGNC Symbol%3BAcc:HGNC:12412]
ENSG00000109184	34.13	28.92	31.58	29.61	28.16	28.99	0.141888313248285	5.37780401202806	0.0689204936952709	0.353662707002645	4:51842999-51916837:+	DCUN1D4	10;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032182,molecular_function ubiquitin-like protein binding;GO:0045116,biological_process protein neddylation;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0097602,molecular_function cullin family protein binding	NA	defective in cullin neddylation 1 domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:28998]
ENSG00000188313	62.48	65.61	65.27	72.20	63.92	78.94	-0.143191936277384	6.02586960818554	0.0689538835229619	0.353687833128316	3:146515179-146544864:-	PLSCR1	35;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006659,biological_process phosphatidylserine biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0006953,biological_process acute-phase response;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017121,biological_process phospholipid scrambling;GO:0017124,molecular_function SH3 domain binding;GO:0017128,molecular_function phospholipid scramblase activity;GO:0019899,molecular_function enzyme binding;GO:0030168,biological_process platelet activation;GO:0031012,cellular_component extracellular matrix;GO:0033003,biological_process regulation of mast cell activation;GO:0035456,biological_process response to interferon-beta;GO:0042609,molecular_function CD4 receptor binding;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045089,biological_process positive regulation of innate immune response;GO:0045121,cellular_component membrane raft;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051607,biological_process defense response to virus;GO:0060368,biological_process regulation of Fc receptor mediated stimulatory signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:2000373,biological_process positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	NA	phospholipid scramblase 1 [Source:HGNC Symbol%3BAcc:HGNC:9092]
ENSG00000139636	20.97	18.57	22.58	18.31	18.80	19.46	0.152133498268159	5.1883632514686	0.0690147418272386	0.35370600872431	12:49096550-49110900:-	LMBR1L	4;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	limb development membrane protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:18268]
ENSG00000144320	13.18	14.38	14.81	10.84	13.39	13.18	0.189098313787729	4.20984324713332	0.0690417527461828	0.35370600872431	2:175923891-176002839:-	LNPK	15;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007275,biological_process multicellular organism development;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0046872,molecular_function metal ion binding;GO:0060173,biological_process limb development;GO:0071787,biological_process endoplasmic reticulum tubular network assembly;GO:0071788,biological_process endoplasmic reticulum tubular network maintenance;GO:0098826,cellular_component endoplasmic reticulum tubular network membrane	NA	lunapark%2C ER junction formation factor [Source:HGNC Symbol%3BAcc:HGNC:21610]
ENSG00000167604	2.25	1.91	2.01	1.14	1.82	1.68	0.426349967248256	1.51741355026235	0.0690521056388684	0.35370600872431	19:35887652-35902303:-	NFKBID	10;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0033085,biological_process negative regulation of T cell differentiation in thymus;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051059,molecular_function NF-kappaB binding;GO:0070245,biological_process positive regulation of thymocyte apoptotic process	NA	NFKB inhibitor delta [Source:HGNC Symbol%3BAcc:HGNC:15671]
ENSG00000142669	251.19	234.68	250.29	282.32	258.37	267.08	-0.120511531624762	6.39929688872773	0.0691222434221592	0.35370600872431	1:26279175-26281522:+	SH3BGRL3	15;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0009055,molecular_function electron carrier activity;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016604,cellular_component nuclear body;GO:0030027,cellular_component lamellipodium;GO:0030215,molecular_function semaphorin receptor binding;GO:0030834,biological_process regulation of actin filament depolymerization;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0043535,biological_process regulation of blood vessel endothelial cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	SH3 domain binding glutamate rich protein like 3 [Source:HGNC Symbol%3BAcc:HGNC:15568]
ENSG00000164104	201.97	233.66	180.07	221.03	246.76	225.20	-0.160669348889738	7.09685416803761	0.0691280539165109	0.35370600872431	4:173331694-173335125:-	HMGB2	72;GO:0000400,molecular_function four-way junction DNA binding;GO:0000790,cellular_component nuclear chromatin;GO:0000793,cellular_component condensed chromosome;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002376,biological_process immune system process;GO:0002437,biological_process inflammatory response to antigenic stimulus;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006265,biological_process DNA topological change;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006310,biological_process DNA recombination;GO:0006325,biological_process chromatin organization;GO:0006334,biological_process nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007283,biological_process spermatogenesis;GO:0007289,biological_process spermatid nucleus differentiation;GO:0008134,molecular_function transcription factor binding;GO:0008144,molecular_function drug binding;GO:0008301,molecular_function DNA binding, bending;GO:0008584,biological_process male gonad development;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0019904,molecular_function protein domain specific binding;GO:0032075,biological_process positive regulation of nuclease activity;GO:0032392,biological_process DNA geometric change;GO:0032496,biological_process response to lipopolysaccharide;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0033151,biological_process V(D)J recombination;GO:0042056,molecular_function chemoattractant activity;GO:0042493,biological_process response to drug;GO:0043234,cellular_component protein complex;GO:0043388,biological_process positive regulation of DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044378,molecular_function non-sequence-specific DNA binding, bending;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045654,biological_process positive regulation of megakaryocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048545,biological_process response to steroid hormone;GO:0050767,biological_process regulation of neurogenesis;GO:0050786,molecular_function RAGE receptor binding;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0050918,biological_process positive chemotaxis;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0060326,biological_process cell chemotaxis;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0072091,biological_process regulation of stem cell proliferation;GO:0097100,molecular_function supercoiled DNA binding;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	NA	high mobility group box 2 [Source:HGNC Symbol%3BAcc:HGNC:5000]
ENSG00000133657	61.43	63.58	66.11	57.55	60.95	59.81	0.111895127301088	7.9102695070603	0.0691283958080381	0.35370600872431	3:194402671-194498364:-	ATP13A3	14;GO:0000166,molecular_function nucleotide binding;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005524,molecular_function ATP binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0006812,biological_process cation transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0070588,biological_process calcium ion transmembrane transport;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	NA	ATPase 13A3 [Source:HGNC Symbol%3BAcc:HGNC:24113]
ENSG00000254402	14.59	15.46	14.54	12.75	13.06	14.39	0.156476588785473	4.45142760002244	0.0691771579078756	0.353809666712179	8:144522376-144527032:-	LRRC24	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051965,biological_process positive regulation of synapse assembly	NA	leucine rich repeat containing 24 [Source:HGNC Symbol%3BAcc:HGNC:28947]
ENSG00000106305	44.53	47.04	43.07	49.30	49.23	49.35	-0.12675263607282	5.51707346333457	0.0692395121801819	0.353895367635915	7:6009244-6023834:+	AIMP2	18;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006461,biological_process protein complex assembly;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0030154,biological_process cell differentiation;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032947,molecular_function protein complex scaffold;GO:0060510,biological_process Type II pneumocyte differentiation;GO:1901216,biological_process positive regulation of neuron death;GO:1903632,biological_process positive regulation of aminoacyl-tRNA ligase activity	NA	aminoacyl tRNA synthetase complex interacting multifunctional protein 2 [Source:HGNC Symbol%3BAcc:HGNC:20609]
ENSG00000008869	6.77	6.57	7.01	5.87	6.43	6.45	0.1310862239343	5.37552320718934	0.0692980910562384	0.353895367635915	2:36968382-37084342:-	HEATR5B	2;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	NA	HEAT repeat containing 5B [Source:HGNC Symbol%3BAcc:HGNC:29273]
ENSG00000155438	51.82	49.58	51.33	57.07	51.34	61.12	-0.138311391522491	5.56826854346849	0.0693063617052462	0.353895367635915	2:121726944-121736923:-	NIFK	13;GO:0000794,cellular_component condensed nuclear chromosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006461,biological_process protein complex assembly;GO:0009303,biological_process rRNA transcription;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016072,biological_process rRNA metabolic process	NA	nucleolar protein interacting with the FHA domain of MKI67 [Source:HGNC Symbol%3BAcc:HGNC:17838]
ENSG00000112640	35.48	38.32	37.50	40.37	41.34	39.96	-0.118418277300346	6.17254403655464	0.0693598069534532	0.353895367635915	6:42984498-43012342:+	PPP2R5D	12;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0050790,biological_process regulation of catalytic activity	PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'; K11584	protein phosphatase 2 regulatory subunit B'delta [Source:HGNC Symbol%3BAcc:HGNC:9312]
ENSG00000082516	7.26	7.79	6.51	8.14	7.54	8.44	-0.155970551248139	5.11286834809842	0.0693602083256799	0.353895367635915	5:154887415-154938209:-	GEMIN5	28;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0006461,biological_process protein complex assembly;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0017069,molecular_function snRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030619,molecular_function U1 snRNA binding;GO:0030621,molecular_function U4 snRNA binding;GO:0030622,molecular_function U4atac snRNA binding;GO:0032797,cellular_component SMN complex;GO:0034718,cellular_component SMN-Gemin2 complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0043022,molecular_function ribosome binding;GO:0051170,biological_process nuclear import;GO:0097504,cellular_component Gemini of coiled bodies	GEMIN5; gem associated protein 5; K13133	gem nuclear organelle associated protein 5 [Source:HGNC Symbol%3BAcc:HGNC:20043]
ENSG00000123992	35.25	30.31	36.65	40.91	33.60	40.95	-0.161160314653797	5.94801660508809	0.0693649745797294	0.353895367635915	2:219373545-219400022:-	DNPEP	15;GO:0004177,molecular_function aminopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006518,biological_process peptide metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0072562,cellular_component blood microparticle	NA	aspartyl aminopeptidase [Source:HGNC Symbol%3BAcc:HGNC:2981]
ENSG00000246922	1.26	1.86	1.91	1.28	0.68	1.49	0.538355771189806	0.907509140363455	0.0694554781122739	0.354211524160911	15:65092769-65115197:-	UBAP1L	3;GO:0000813,cellular_component ESCRT I complex;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NA	ubiquitin associated protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:40028]
ENSG00000068366	56.69	66.31	55.45	50.55	59.91	50.70	0.157229152499982	6.91663864978724	0.0695246702045736	0.354418780800563	X:109624243-109733403:-	ACSL4	36;GO:0000166,molecular_function nucleotide binding;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0015908,biological_process fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0030182,biological_process neuron differentiation;GO:0031090,cellular_component organelle membrane;GO:0031957,molecular_function very long-chain fatty acid-CoA ligase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0047676,molecular_function arachidonate-CoA ligase activity;GO:0060136,biological_process embryonic process involved in female pregnancy;GO:0060996,biological_process dendritic spine development;GO:0070062,cellular_component extracellular exosome;GO:0070672,biological_process response to interleukin-15;GO:0102391,molecular_function decanoate--CoA ligase activity	ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]; K01897	acyl-CoA synthetase long chain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:3571]
ENSG00000205220	33.97	27.24	34.09	40.73	29.99	41.34	-0.217554479994679	4.87783216044722	0.0696906925080825	0.354991881836189	16:67934501-67937087:-	PSMB10	42;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006959,biological_process humoral immune response;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1990111,cellular_component spermatoproteasome complex	PSMB10, MECL1; 20S proteasome subunit beta 10 [EC:3.4.25.1]; K02733	proteasome subunit beta 10 [Source:HGNC Symbol%3BAcc:HGNC:9538]
ENSG00000148848	6.69	7.74	6.79	6.54	6.30	6.04	0.173101351510983	4.2473332967908	0.0697015978462066	0.354991881836189	10:126012380-126388455:-	ADAM12	16;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007155,biological_process cell adhesion;GO:0007520,biological_process myoblast fusion;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030198,biological_process extracellular matrix organization;GO:0046872,molecular_function metal ion binding	NA	ADAM metallopeptidase domain 12 [Source:HGNC Symbol%3BAcc:HGNC:190]
ENSG00000198934	2.56	3.20	2.82	2.37	2.72	2.01	0.276197140409145	2.92480437597094	0.0697484535820639	0.354991881836189	X:76427723-76431353:+	MAGEE1	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016020,cellular_component membrane;GO:0030425,cellular_component dendrite;GO:0045211,cellular_component postsynaptic membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	MAGE family member E1 [Source:HGNC Symbol%3BAcc:HGNC:24934]
ENSG00000171346	5.58	3.54	4.38	6.55	4.35	6.59	-0.349719216199659	2.93093282648575	0.0697514863287252	0.354991881836189	17:41513742-41522529:-	KRT15	12;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0007010,biological_process cytoskeleton organization;GO:0008544,biological_process epidermis development;GO:0031424,biological_process keratinization;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0097110,molecular_function scaffold protein binding	KRT1; type I keratin, acidic; K07604	keratin 15 [Source:HGNC Symbol%3BAcc:HGNC:6421]
ENSG00000172667	2.93	2.31	2.21	3.11	2.97	4.06	-0.425701292536053	1.44395975979799	0.0698260518341934	0.35522573008928	3:179017222-179072279:-	ZMAT3	17;GO:0002039,molecular_function p53 binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0040008,biological_process regulation of growth;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	ZMAT3; zinc finger, matrin type 3; K10137	zinc finger matrin-type 3 [Source:HGNC Symbol%3BAcc:HGNC:29983]
ENSG00000131941	23.03	23.22	26.97	27.21	26.57	27.40	-0.135675978875285	5.73328358745801	0.0700171364776668	0.355999920583981	19:32978592-33064888:-	RHPN2	4;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	rhophilin Rho GTPase binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:19974]
ENSG00000213160	9.35	8.14	9.66	9.78	10.34	11.00	-0.178578010939331	4.09657844525808	0.0700355922070476	0.355999920583981	2:169694487-169776989:+	KLHL23	4;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch like family member 23 [Source:HGNC Symbol%3BAcc:HGNC:27506]
ENSG00000182196	66.90	69.77	62.97	72.18	72.31	74.14	-0.121116838234812	6.51368873520805	0.0702299151332416	0.356841562238612	12:122980059-122982913:+	ARL6IP4	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck	NA	ADP ribosylation factor like GTPase 6 interacting protein 4 [Source:HGNC Symbol%3BAcc:HGNC:18076]
ENSG00000198169	14.94	14.32	15.53	13.84	13.60	13.71	0.137169763271972	4.96940242309526	0.0703278674264004	0.356881546898391	8:144720906-144756417:-	ZNF251	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 251 [Source:HGNC Symbol%3BAcc:HGNC:13045]
ENSG00000241058	8.31	6.38	8.28	6.49	5.87	7.26	0.249548996012462	3.45128811459728	0.0703606450741907	0.356881546898391	10:18545560-18659285:-	NSUN6	10;GO:0000049,molecular_function tRNA binding;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008168,molecular_function methyltransferase activity;GO:0016428,molecular_function tRNA (cytosine-5-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	NOP2/Sun RNA methyltransferase family member 6 [Source:HGNC Symbol%3BAcc:HGNC:23529]
ENSG00000244219	10.44	5.91	9.21	7.91	5.26	6.47	0.409073043802263	2.37786412687175	0.0704000609530015	0.356881546898391	7:99598065-99610813:+	TMEM225B	3;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 225B [Source:HGNC Symbol%3BAcc:HGNC:53075]
ENSG00000131504	30.62	33.59	29.88	35.92	33.09	34.37	-0.125993639501839	7.00216872250895	0.0704003971167706	0.356881546898391	5:141515015-141619055:-	DIAPH1	33;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007015,biological_process actin filament organization;GO:0007605,biological_process sensory perception of sound;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030041,biological_process actin filament polymerization;GO:0030335,biological_process positive regulation of cell migration;GO:0030667,cellular_component secretory granule membrane;GO:0032587,cellular_component ruffle membrane;GO:0032886,biological_process regulation of microtubule-based process;GO:0035372,biological_process protein localization to microtubule;GO:0042995,cellular_component cell projection;GO:0043312,biological_process neutrophil degranulation;GO:0044325,molecular_function ion channel binding;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0071420,biological_process cellular response to histamine;GO:0072686,cellular_component mitotic spindle;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:2000145,biological_process regulation of cell motility	DIAPH1; diaphanous 1; K05740	diaphanous related formin 1 [Source:HGNC Symbol%3BAcc:HGNC:2876]
ENSG00000106785	5.86	6.34	6.44	7.62	6.86	7.48	-0.228658853646342	3.19247757843711	0.0704358997660014	0.356881546898391	9:98069274-98119212:-	TRIM14	8;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0008270,molecular_function zinc ion binding;GO:0032897,biological_process negative regulation of viral transcription;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	NA	tripartite motif containing 14 [Source:HGNC Symbol%3BAcc:HGNC:16283]
ENSG00000143458	5.31	4.91	4.76	6.57	4.97	6.75	-0.276433514914661	2.93372423227241	0.0704608254552945	0.356881546898391	1:151070577-151125542:+	GABPB2	9;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042803,molecular_function protein homodimerization activity;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity	NA	GA binding protein transcription factor beta subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:28441]
ENSG00000144597	10.37	10.22	11.53	12.48	12.92	12.33	-0.216009783333172	3.25444665928124	0.0704833002092463	0.356881546898391	3:15427354-15450635:+	EAF1	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008023,cellular_component transcription elongation factor complex;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0032783,cellular_component ELL-EAF complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045171,cellular_component intercellular bridge	NA	ELL associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:20907]
ENSG00000102910	19.40	21.65	20.43	21.80	22.76	22.88	-0.125034148034977	5.87470254769064	0.0704907391132761	0.356881546898391	16:48244295-48363122:+	LONP2	24;GO:0000166,molecular_function nucleotide binding;GO:0002020,molecular_function protease binding;GO:0004176,molecular_function ATP-dependent peptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006508,biological_process proteolysis;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0006625,biological_process protein targeting to peroxisome;GO:0007031,biological_process peroxisome organization;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0030163,biological_process protein catabolic process;GO:0031998,biological_process regulation of fatty acid beta-oxidation	NA	lon peptidase 2%2C peroxisomal [Source:HGNC Symbol%3BAcc:HGNC:20598]
ENSG00000188229	239.33	276.03	215.84	249.40	325.81	264.31	-0.187912821086818	8.45004719319792	0.0705033745350257	0.356881546898391	9:137241212-137243707:+	TUBB4B	27;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006928,biological_process movement of cell or subcellular component;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0031012,cellular_component extracellular matrix;GO:0035578,cellular_component azurophil granule lumen;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0042288,molecular_function MHC class I protein binding;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0051082,molecular_function unfolded protein binding;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1903561,cellular_component extracellular vesicle	TUBB; tubulin beta; K07375	tubulin beta 4B class IVb [Source:HGNC Symbol%3BAcc:HGNC:20771]
ENSG00000070159	23.48	26.11	23.85	20.43	25.16	20.98	0.15168594914327	6.05988439488582	0.0705252907872193	0.356881546898391	9:109375465-109498313:-	PTPN3	23;GO:0001784,molecular_function phosphotyrosine binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017080,molecular_function sodium channel regulator activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0051045,biological_process negative regulation of membrane protein ectodomain proteolysis;GO:0051117,molecular_function ATPase binding;GO:0097421,biological_process liver regeneration;GO:0098902,biological_process regulation of membrane depolarization during action potential;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	NA	protein tyrosine phosphatase%2C non-receptor type 3 [Source:HGNC Symbol%3BAcc:HGNC:9655]
ENSG00000154144	26.29	26.66	26.26	24.84	22.45	25.15	0.139033680320213	4.96877368563696	0.0705799904463517	0.357012804160784	11:124622835-124635398:+	TBRG1	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008285,biological_process negative regulation of cell proliferation;GO:0032066,biological_process nucleolus to nucleoplasm transport;GO:0050821,biological_process protein stabilization	NA	transforming growth factor beta regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:29551]
ENSG00000168032	0.33	0.73	0.39	0.87	0.71	0.70	-0.701633634978114	0.267663025298053	0.0707409658113111	0.357681306971814	3:40387155-40428619:+	ENTPD3	13;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0009134,biological_process nucleoside diphosphate catabolic process;GO:0009143,biological_process nucleoside triphosphate catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0102490,molecular_function 8-oxo-dGTP phosphohydrolase activity	ENTPD1_3_8, CD39; apyrase [EC:3.6.1.5]; K01510	ectonucleoside triphosphate diphosphohydrolase 3 [Source:HGNC Symbol%3BAcc:HGNC:3365]
ENSG00000167601	115.45	107.25	109.66	130.26	111.19	124.43	-0.126656847461625	8.28769743017229	0.0708155387586587	0.357769006187871	19:41219202-41261766:+	AXL	67;GO:0000166,molecular_function nucleotide binding;GO:0001618,molecular_function virus receptor activity;GO:0001764,biological_process neuron migration;GO:0001779,biological_process natural killer cell differentiation;GO:0001786,molecular_function phosphatidylserine binding;GO:0001818,biological_process negative regulation of cytokine production;GO:0001961,biological_process positive regulation of cytokine-mediated signaling pathway;GO:0001974,biological_process blood vessel remodeling;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006909,biological_process phagocytosis;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007167,biological_process enzyme linked receptor protein signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021885,biological_process forebrain cell migration;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0031100,biological_process organ regeneration;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032036,molecular_function myosin heavy chain binding;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032825,biological_process positive regulation of natural killer cell differentiation;GO:0032940,biological_process secretion by cell;GO:0034101,biological_process erythrocyte homeostasis;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035457,biological_process cellular response to interferon-alpha;GO:0042698,biological_process ovulation cycle;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043277,biological_process apoptotic cell clearance;GO:0043491,biological_process protein kinase B signaling;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0044228,cellular_component host cell surface;GO:0045087,biological_process innate immune response;GO:0046718,biological_process viral entry into host cell;GO:0046982,molecular_function protein heterodimerization activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048469,biological_process cell maturation;GO:0048549,biological_process positive regulation of pinocytosis;GO:0051250,biological_process negative regulation of lymphocyte activation;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060068,biological_process vagina development;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0097028,biological_process dendritic cell differentiation;GO:0097350,biological_process neutrophil clearance;GO:2000669,biological_process negative regulation of dendritic cell apoptotic process	AXL, UFO; AXL receptor tyrosine kinase [EC:2.7.10.1]; K05115	AXL receptor tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:905]
ENSG00000166455	2.93	2.38	3.05	4.47	3.27	3.21	-0.361688300803271	2.02233639169676	0.0708268415834122	0.357769006187871	16:81053496-81077267:-	C16orf46	3;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol	NA	chromosome 16 open reading frame 46 [Source:HGNC Symbol%3BAcc:HGNC:26525]
ENSG00000163798	17.21	19.67	16.00	19.02	19.23	20.79	-0.15305022662546	5.5059706618064	0.0708526812150409	0.357769006187871	2:27663470-27694976:+	SLC4A1AP	7;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	solute carrier family 4 member 1 adaptor protein [Source:HGNC Symbol%3BAcc:HGNC:13813]
ENSG00000187091	3.55	3.60	3.05	2.66	2.85	3.09	0.250149005592523	2.91519073478594	0.0708735991473434	0.357769006187871	3:38007495-38029762:-	PLCD1	25;GO:0001525,biological_process angiogenesis;GO:0001786,molecular_function phosphatidylserine binding;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0032794,molecular_function GTPase activating protein binding;GO:0035556,biological_process intracellular signal transduction;GO:0042127,biological_process regulation of cell proliferation;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0070062,cellular_component extracellular exosome;GO:0070300,molecular_function phosphatidic acid binding;GO:1901981,molecular_function phosphatidylinositol phosphate binding	PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]; K05857	phospholipase C delta 1 [Source:HGNC Symbol%3BAcc:HGNC:9060]
ENSG00000164830	26.84	24.99	26.75	23.75	24.04	25.33	0.117303442445902	6.26320346381207	0.0709439427172739	0.357962460233697	8:106359475-106752694:+	OXR1	14;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006979,biological_process response to oxidative stress;GO:0007628,biological_process adult walking behavior;GO:0016491,molecular_function oxidoreductase activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0051402,biological_process neuron apoptotic process;GO:0055114,biological_process oxidation-reduction process;GO:0071447,biological_process cellular response to hydroperoxide;GO:1900408,biological_process negative regulation of cellular response to oxidative stress;GO:1902083,biological_process negative regulation of peptidyl-cysteine S-nitrosylation;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death	NA	oxidation resistance 1 [Source:HGNC Symbol%3BAcc:HGNC:15822]
ENSG00000137145	35.74	36.33	37.52	32.69	34.94	34.72	0.110590491762352	7.71158087443493	0.0709715866831841	0.357962460233697	9:19230434-19373545:+	DENND4C	18;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030904,cellular_component retromer complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032593,cellular_component insulin-responsive compartment;GO:0032869,biological_process cellular response to insulin stimulus;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization;GO:0072659,biological_process protein localization to plasma membrane	NA	DENN domain containing 4C [Source:HGNC Symbol%3BAcc:HGNC:26079]
ENSG00000137166	12.31	10.99	12.05	13.78	12.59	13.24	-0.147190928633377	4.76411629820887	0.0709984352771579	0.357962460233697	6:41546425-41602384:+	FOXP4	12;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	forkhead box P4 [Source:HGNC Symbol%3BAcc:HGNC:20842]
ENSG00000168517	6.96	7.14	8.68	9.24	9.93	8.37	-0.256268495638832	2.98642893454015	0.071053047062807	0.358092356147228	17:45160699-45170040:+	HEXIM2	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016607,cellular_component nuclear speck;GO:0017069,molecular_function snRNA binding;GO:0042802,molecular_function identical protein binding;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0097322,molecular_function 7SK snRNA binding	NA	hexamethylene bisacetamide inducible 2 [Source:HGNC Symbol%3BAcc:HGNC:28591]
ENSG00000124275	51.74	45.79	48.49	45.63	42.45	46.90	0.126594840639379	6.69725589391705	0.0711993759958207	0.358597062390109	5:7851185-7906025:+	MTRR	25;GO:0000096,biological_process sulfur amino acid metabolic process;GO:0003958,molecular_function NADPH-hemoprotein reductase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006306,biological_process DNA methylation;GO:0006555,biological_process methionine metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009086,biological_process methionine biosynthetic process;GO:0009235,biological_process cobalamin metabolic process;GO:0010181,molecular_function FMN binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016723,molecular_function oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor;GO:0030586,molecular_function [methionine synthase] reductase activity;GO:0032259,biological_process methylation;GO:0033353,biological_process S-adenosylmethionine cycle;GO:0043418,biological_process homocysteine catabolic process;GO:0046655,biological_process folic acid metabolic process;GO:0050444,molecular_function aquacobalamin reductase (NADPH) activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process;GO:0070402,molecular_function NADPH binding;GO:0071949,molecular_function FAD binding;GO:1904042,biological_process negative regulation of cystathionine beta-synthase activity	NA	5-methyltetrahydrofolate-homocysteine methyltransferase reductase [Source:HGNC Symbol%3BAcc:HGNC:7473]
ENSG00000136114	2.07	1.72	2.07	2.11	2.23	3.14	-0.331268939653855	2.55832455523729	0.0712322346871154	0.358597062390109	13:52377166-52406494:-	THSD1	4;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	thrombospondin type 1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17754]
ENSG00000196605	5.30	5.56	5.85	4.87	4.51	4.97	0.229127285669	3.07314142573872	0.0712398578791597	0.358597062390109	19:9751992-9793180:-	ZNF846	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 846 [Source:HGNC Symbol%3BAcc:HGNC:27260]
ENSG00000109736	56.57	56.29	59.75	60.63	62.50	65.68	-0.117250412161629	6.47437021961297	0.0713740889607956	0.359052756989069	4:2930560-2934859:-	MFSD10	11;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0008493,molecular_function tetracycline transporter activity;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0015904,biological_process tetracycline transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031526,cellular_component brush border membrane;GO:0043252,biological_process sodium-independent organic anion transport;GO:0055085,biological_process transmembrane transport	NA	major facilitator superfamily domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:16894]
ENSG00000085733	167.26	182.01	173.81	157.29	172.88	154.70	0.120852326912724	8.44682351777016	0.0713882384797408	0.359052756989069	11:70398403-70436584:+	CTTN	43;GO:0001726,cellular_component ruffle;GO:0002102,cellular_component podosome;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006930,biological_process substrate-dependent cell migration, cell extension;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030041,biological_process actin filament polymerization;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030516,biological_process regulation of axon extension;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0030863,cellular_component cortical cytoskeleton;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0048041,biological_process focal adhesion assembly;GO:0048812,biological_process neuron projection morphogenesis;GO:0048870,biological_process cell motility;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0097062,biological_process dendritic spine maintenance;GO:0097581,biological_process lamellipodium organization;GO:1903146,biological_process regulation of mitophagy;GO:1990023,cellular_component mitotic spindle midzone;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	CTTN, EMS1; cortactin; K06106	cortactin [Source:HGNC Symbol%3BAcc:HGNC:3338]
ENSG00000161996	5.36	5.02	5.33	4.90	4.88	4.60	0.14392463412379	4.82307033416234	0.0714458641578895	0.359197048113359	16:649310-667833:+	WDR90	1;GO:0005515,molecular_function protein binding	NA	WD repeat domain 90 [Source:HGNC Symbol%3BAcc:HGNC:26960]
ENSG00000162368	106.20	112.95	106.81	93.51	102.56	105.43	0.12229147699209	6.1696796331296	0.0714992556998227	0.359301222512017	1:47333796-47378839:+	CMPK1	26;GO:0000166,molecular_function nucleotide binding;GO:0004127,molecular_function cytidylate kinase activity;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0004849,molecular_function uridine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006207,biological_process 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0006222,biological_process UMP biosynthetic process;GO:0009041,molecular_function uridylate kinase activity;GO:0009142,biological_process nucleoside triphosphate biosynthetic process;GO:0009220,biological_process pyrimidine ribonucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0046939,biological_process nucleotide phosphorylation;GO:0046940,biological_process nucleoside monophosphate phosphorylation;GO:0050145,molecular_function nucleoside phosphate kinase activity;GO:0070062,cellular_component extracellular exosome	CMPK1, UMPK; UMP-CMP kinase [EC:2.7.4.14]; K13800	cytidine/uridine monophosphate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:18170]
ENSG00000141542	11.26	13.18	14.12	10.59	12.37	9.61	0.254209558019895	3.32200456027145	0.0715244760192697	0.359301222512017	17:82654972-82698728:-	RAB40B	15;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005635,cellular_component nuclear envelope;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0030667,cellular_component secretory granule membrane;GO:0035556,biological_process intracellular signal transduction;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0072659,biological_process protein localization to plasma membrane;GO:1990967,biological_process multi-organism toxin transport	NA	RAB40B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:18284]
ENSG00000164161	1.52	1.37	1.55	1.04	1.43	0.91	0.415899930746054	1.61070914373353	0.0716448595351654	0.359760372738676	4:144646020-144745271:+	HHIP	24;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007224,biological_process smoothened signaling pathway;GO:0007405,biological_process neuroblast proliferation;GO:0008270,molecular_function zinc ion binding;GO:0009887,biological_process organ morphogenesis;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009968,biological_process negative regulation of signal transduction;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0040036,biological_process regulation of fibroblast growth factor receptor signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0048705,biological_process skeletal system morphogenesis;GO:0060170,cellular_component ciliary membrane;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0097108,molecular_function hedgehog family protein binding	HHIP; hedgehog interacting protein; K06231	hedgehog interacting protein [Source:HGNC Symbol%3BAcc:HGNC:14866]
ENSG00000096968	3.99	4.16	4.07	5.25	4.53	4.33	-0.194908219398121	3.9139505243272	0.0717700326856008	0.360243192772488	9:4984389-5128183:+	JAK2	123;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005131,molecular_function growth hormone receptor binding;GO:0005143,molecular_function interleukin-12 receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006928,biological_process movement of cell or subcellular component;GO:0006979,biological_process response to oxidative stress;GO:0007165,biological_process signal transduction;GO:0007167,biological_process enzyme linked receptor protein signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007259,biological_process JAK-STAT cascade;GO:0007260,biological_process tyrosine phosphorylation of STAT protein;GO:0007262,biological_process STAT protein import into nucleus;GO:0007498,biological_process mesoderm development;GO:0007596,biological_process blood coagulation;GO:0008022,molecular_function protein C-terminus binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0012505,cellular_component endomembrane system;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016363,cellular_component nuclear matrix;GO:0016477,biological_process cell migration;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019901,molecular_function protein kinase binding;GO:0020037,molecular_function heme binding;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030041,biological_process actin filament polymerization;GO:0030154,biological_process cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0031103,biological_process axon regeneration;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0031904,cellular_component endosome lumen;GO:0031959,biological_process mineralocorticoid receptor signaling pathway;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032496,biological_process response to lipopolysaccharide;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0032731,biological_process positive regulation of interleukin-1 beta production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0033130,molecular_function acetylcholine receptor binding;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0033194,biological_process response to hydroperoxide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034612,biological_process response to tumor necrosis factor;GO:0035401,molecular_function histone kinase activity (H3-Y41 specific);GO:0035409,biological_process histone H3-Y41 phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0042169,molecular_function SH2 domain binding;GO:0042393,molecular_function histone binding;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042976,biological_process activation of Janus kinase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043388,biological_process positive regulation of DNA binding;GO:0043392,biological_process negative regulation of DNA binding;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043560,molecular_function insulin receptor substrate binding;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045822,biological_process negative regulation of heart contraction;GO:0046677,biological_process response to antibiotic;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0050727,biological_process regulation of inflammatory response;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050867,biological_process positive regulation of cell activation;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051428,molecular_function peptide hormone receptor binding;GO:0051770,biological_process positive regulation of nitric-oxide synthase biosynthetic process;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0060396,biological_process growth hormone receptor signaling pathway;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway;GO:0060399,biological_process positive regulation of growth hormone receptor signaling pathway;GO:0060548,biological_process negative regulation of cell death;GO:0061180,biological_process mammary gland epithelium development;GO:0070671,biological_process response to interleukin-12;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1902728,biological_process positive regulation of growth factor dependent skeletal muscle satellite cell proliferation;GO:1904037,biological_process positive regulation of epithelial cell apoptotic process;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation	JAK2; Janus kinase 2 [EC:2.7.10.2]; K04447	Janus kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6192]
ENSG00000171490	143.21	137.86	148.08	151.47	151.33	166.09	-0.115530246421631	7.82617515115219	0.0718198606959307	0.360347587234676	16:11833849-11851585:-	RSL1D1	13;GO:0000470,biological_process maturation of LSU-rRNA;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0016020,cellular_component membrane;GO:0030686,cellular_component 90S preribosome;GO:0032880,biological_process regulation of protein localization;GO:0042981,biological_process regulation of apoptotic process;GO:0045296,molecular_function cadherin binding;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:2000772,biological_process regulation of cellular senescence	NA	ribosomal L1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24534]
ENSG00000115661	23.95	27.30	21.31	27.60	25.50	29.40	-0.18136097019926	4.76919843350866	0.07188766407856	0.360542050184713	2:219245454-219250337:+	STK16	21;GO:0000166,molecular_function nucleotide binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005829,cellular_component cytosol;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus	NA	serine/threonine kinase 16 [Source:HGNC Symbol%3BAcc:HGNC:11394]
ENSG00000103707	7.93	7.62	8.45	8.79	9.49	9.82	-0.212625525089095	3.36786860580556	0.0719745916409871	0.360696368320896	15:65001511-65029639:-	MTFMT	9;GO:0003824,molecular_function catalytic activity;GO:0004479,molecular_function methionyl-tRNA formyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016742,molecular_function hydroxymethyl-, formyl- and related transferase activity;GO:0071951,biological_process conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]; K00604	mitochondrial methionyl-tRNA formyltransferase [Source:HGNC Symbol%3BAcc:HGNC:29666]
ENSG00000048991	15.82	14.91	16.57	16.83	17.78	17.29	-0.119455531175782	5.8844622685596	0.0719765491284025	0.360696368320896	2:135531454-135725270:+	R3HDM1	2;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding	NA	R3H domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:9757]
ENSG00000131969	1.24	0.70	1.63	2.07	1.68	1.62	-0.532066529415225	0.845618808378993	0.0721709373335232	0.361524554124707	14:50872159-50904970:+	ABHD12B	1;GO:0016787,molecular_function hydrolase activity	NA	abhydrolase domain containing 12B [Source:HGNC Symbol%3BAcc:HGNC:19837]
ENSG00000198901	70.34	71.49	66.64	72.37	80.52	75.40	-0.119845454736449	7.17137607115528	0.0722264717290954	0.361656794503131	15:90966037-90995629:-	PRC1	24;GO:0000022,biological_process mitotic spindle elongation;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000910,biological_process cytokinesis;GO:0000922,cellular_component spindle pole;GO:0001578,biological_process microtubule bundle formation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019894,molecular_function kinesin binding;GO:0019901,molecular_function protein kinase binding;GO:0030496,cellular_component midbody;GO:0051301,biological_process cell division;GO:0070938,cellular_component contractile ring	NA	protein regulator of cytokinesis 1 [Source:HGNC Symbol%3BAcc:HGNC:9341]
ENSG00000153165	0.24	0.25	0.33	0.16	0.21	0.19	0.584670974821481	0.452402241031818	0.0722808993337648	0.361783388479848	2:106391289-106468376:-	RGPD3	3;GO:0000042,biological_process protein targeting to Golgi;GO:0005622,cellular_component intracellular;GO:0046907,biological_process intracellular transport	NA	RANBP2-like and GRIP domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:32416]
ENSG00000181577	6.61	6.21	6.51	8.76	6.61	8.60	-0.296329601436695	2.51908230413933	0.0723341233165262	0.361903858415171	6:44000579-44005958:+	C6orf223	NA	NA	chromosome 6 open reading frame 223 [Source:HGNC Symbol%3BAcc:HGNC:28692]
ENSG00000011105	22.93	21.09	21.81	20.83	18.95	20.23	0.148271736157271	4.74347096621881	0.0724772385501646	0.362473796181786	12:3077354-3286564:+	TSPAN9	9;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0097197,cellular_component tetraspanin-enriched microdomain	NA	tetraspanin 9 [Source:HGNC Symbol%3BAcc:HGNC:21640]
ENSG00000021355	100.81	94.14	104.35	113.59	101.19	115.09	-0.12744433086455	6.90126912797249	0.0725317296472853	0.362600225578636	6:2832331-2842006:-	SERPINB1	11;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0030414,molecular_function peptidase inhibitor activity;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	SERPINB; serpin B; K13963	serpin family B member 1 [Source:HGNC Symbol%3BAcc:HGNC:3311]
ENSG00000112983	14.91	15.60	14.15	15.75	18.58	15.42	-0.145583555426861	6.06360922006913	0.0726087495572923	0.362696020138188	5:138139765-138178986:-	BRD8	18;GO:0000812,cellular_component Swr1 complex;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004887,molecular_function thyroid hormone receptor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016569,biological_process covalent chromatin modification;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	bromodomain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:19874]
ENSG00000173267	1.63	1.99	1.70	3.11	2.10	3.25	-0.671647892114304	0.204682472945305	0.0726371114269661	0.362696020138188	10:86958617-86963260:+	SNCG	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007268,biological_process chemical synaptic transmission;GO:0008344,biological_process adult locomotory behavior;GO:0009306,biological_process protein secretion;GO:0014059,biological_process regulation of dopamine secretion;GO:0030424,cellular_component axon;GO:0043025,cellular_component neuronal cell body;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050808,biological_process synapse organization;GO:0070062,cellular_component extracellular exosome	NA	synuclein gamma [Source:HGNC Symbol%3BAcc:HGNC:11141]
ENSG00000168010	27.73	23.91	34.08	26.42	22.17	26.80	0.199626296889996	5.86673596110758	0.0726385487846239	0.362696020138188	11:72814307-72843674:+	ATG16L2	8;GO:0000045,biological_process autophagosome assembly;GO:0000421,cellular_component autophagosome membrane;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0039689,biological_process negative stranded viral RNA replication	NA	autophagy related 16 like 2 [Source:HGNC Symbol%3BAcc:HGNC:25464]
ENSG00000184271	3.47	3.34	3.61	2.66	3.27	2.76	0.27896229192032	2.5805307358935	0.0726900652212095	0.362807309847557	12:51186935-51217708:-	POU6F1	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007517,biological_process muscle organ development;GO:0015629,cellular_component actin cytoskeleton;GO:0016604,cellular_component nuclear body;GO:0043565,molecular_function sequence-specific DNA binding	NA	POU class 6 homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:9224]
ENSG00000100271	12.87	13.26	14.02	15.17	16.22	14.24	-0.170631374132404	4.26567772660592	0.0728168869577167	0.363283938636819	22:43039643-43089428:-	TTLL1	13;GO:0000166,molecular_function nucleotide binding;GO:0003351,biological_process epithelial cilium movement;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006464,biological_process cellular protein modification process;GO:0007288,biological_process sperm axoneme assembly;GO:0016874,molecular_function ligase activity;GO:0018095,biological_process protein polyglutamylation;GO:0035082,biological_process axoneme assembly;GO:0070740,molecular_function tubulin-glutamic acid ligase activity;GO:1905419,biological_process sperm flagellum movement involved in flagellated sperm motility	NA	tubulin tyrosine ligase like 1 [Source:HGNC Symbol%3BAcc:HGNC:1312]
ENSG00000138767	11.20	9.82	9.46	11.75	12.15	10.84	-0.172447905398712	4.32759073261471	0.0728440927468817	0.363283938636819	4:77713386-77819615:-	CNOT6L	23;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010606,biological_process positive regulation of cytoplasmic mRNA processing body assembly;GO:0016787,molecular_function hydrolase activity;GO:0030014,cellular_component CCR4-NOT complex;GO:0031047,biological_process gene silencing by RNA;GO:0046872,molecular_function metal ion binding;GO:0061157,biological_process mRNA destabilization;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	CNOT6, CCR4; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]; K12603	CCR4-NOT transcription complex subunit 6 like [Source:HGNC Symbol%3BAcc:HGNC:18042]
ENSG00000124257	2.68	3.19	2.12	1.46	2.09	2.10	0.484976409409044	1.07352357720449	0.0728852490391782	0.363343211374827	20:45888624-45891287:-	NEURL2	5;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	neuralized E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:16156]
ENSG00000134882	26.36	23.70	23.81	21.93	23.07	22.52	0.144624854829548	4.88443203761658	0.072947968833237	0.363509890456432	13:99200773-99386434:+	UBAC2	10;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006508,biological_process proteolysis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043130,molecular_function ubiquitin binding;GO:0070972,biological_process protein localization to endoplasmic reticulum;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol	NA	UBA domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20486]
ENSG00000139344	0.88	0.52	0.46	1.00	0.77	1.27	-0.664369736076789	0.281120558980049	0.0731650120383521	0.364445142227955	12:95943292-95968716:+	AMDHD1	12;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006547,biological_process histidine metabolic process;GO:0006548,biological_process histidine catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016812,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0019556,biological_process histidine catabolic process to glutamate and formamide;GO:0019557,biological_process histidine catabolic process to glutamate and formate;GO:0046872,molecular_function metal ion binding;GO:0050480,molecular_function imidazolonepropionase activity	hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]; K01468	amidohydrolase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28577]
ENSG00000006576	16.01	14.78	16.65	13.62	13.64	15.91	0.1497035876091	5.19874563721433	0.0732222689472991	0.364584045103419	7:77798791-77957503:+	PHTF2	5;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	putative homeodomain transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:13411]
ENSG00000198911	77.00	84.57	72.77	69.86	76.60	69.41	0.12957964431724	8.1265275748024	0.0732834288400115	0.36468833029779	22:41833078-41907308:+	SREBF2	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000139,cellular_component Golgi membrane;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006629,biological_process lipid metabolic process;GO:0008022,molecular_function protein C-terminus binding;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0009267,biological_process cellular response to starvation;GO:0010886,biological_process positive regulation of cholesterol storage;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032937,cellular_component SREBP-SCAP-Insig complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0055098,biological_process response to low-density lipoprotein particle;GO:0070888,molecular_function E-box binding;GO:0071499,biological_process cellular response to laminar fluid shear stress;GO:0072368,biological_process regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter;GO:0090370,biological_process negative regulation of cholesterol efflux;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2000188,biological_process regulation of cholesterol homeostasis	NA	sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:11290]
ENSG00000148411	7.74	7.98	7.56	6.85	5.90	7.55	0.204962846438248	3.69250155944948	0.0733043313879328	0.36468833029779	9:136006536-136095285:-	NACC2	24;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0016575,biological_process histone deacetylation;GO:0016581,cellular_component NuRD complex;GO:0016604,cellular_component nuclear body;GO:0034629,biological_process cellular protein complex localization;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051260,biological_process protein homooligomerization;GO:1900477,biological_process negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter;GO:1902231,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	NA	NACC family member 2 [Source:HGNC Symbol%3BAcc:HGNC:23846]
ENSG00000159363	11.37	10.49	11.66	10.70	9.42	10.61	0.139408733714014	5.38735018322589	0.073340163631617	0.36468833029779	1:16985957-17011928:-	ATP13A2	58;GO:0000166,molecular_function nucleotide binding;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005776,cellular_component autophagosome;GO:0005887,cellular_component integral component of plasma membrane;GO:0006812,biological_process cation transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0008270,molecular_function zinc ion binding;GO:0010821,biological_process regulation of mitochondrion organization;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016243,biological_process regulation of autophagosome size;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0019829,molecular_function cation-transporting ATPase activity;GO:0030003,biological_process cellular cation homeostasis;GO:0030133,cellular_component transport vesicle;GO:0030145,molecular_function manganese ion binding;GO:0031982,cellular_component vesicle;GO:0032585,cellular_component multivesicular body membrane;GO:0033157,biological_process regulation of intracellular protein transport;GO:0034220,biological_process ion transmembrane transport;GO:0034599,biological_process cellular response to oxidative stress;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043202,cellular_component lysosomal lumen;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050714,biological_process positive regulation of protein secretion;GO:0052548,biological_process regulation of endopeptidase activity;GO:0055069,biological_process zinc ion homeostasis;GO:0070300,molecular_function phosphatidic acid binding;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071287,biological_process cellular response to manganese ion;GO:0071294,biological_process cellular response to zinc ion;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport;GO:1901215,biological_process negative regulation of neuron death;GO:1903135,molecular_function cupric ion binding;GO:1903146,biological_process regulation of mitophagy;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1904714,biological_process regulation of chaperone-mediated autophagy;GO:1905037,biological_process autophagosome organization;GO:1905103,cellular_component integral component of lysosomal membrane;GO:1905122,biological_process polyamine import;GO:1905123,biological_process regulation of glucosylceramidase activity;GO:1905165,biological_process regulation of lysosomal protein catabolic process;GO:1905166,biological_process negative regulation of lysosomal protein catabolic process;GO:1990938,biological_process peptidyl-aspartic acid autophosphorylation	NA	ATPase 13A2 [Source:HGNC Symbol%3BAcc:HGNC:30213]
ENSG00000089335	25.37	24.36	25.73	27.18	27.15	28.61	-0.122754112636262	5.38370857393181	0.0733607315518876	0.36468833029779	19:34677638-34686397:+	ZNF302	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 302 [Source:HGNC Symbol%3BAcc:HGNC:13848]
ENSG00000173039	32.23	32.62	36.18	37.35	34.82	39.34	-0.13006612860549	5.98725851812088	0.0733976446543873	0.364725765850644	11:65653595-65663094:-	RELA	116;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001889,biological_process liver development;GO:0001942,biological_process hair follicle development;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006117,biological_process acetaldehyde metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006968,biological_process cellular defense response;GO:0007568,biological_process aging;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009612,biological_process response to mechanical stimulus;GO:0009617,biological_process response to bacterium;GO:0009887,biological_process organ morphogenesis;GO:0010033,biological_process response to organic substance;GO:0010035,biological_process response to inorganic substance;GO:0010224,biological_process response to UV-B;GO:0014040,biological_process positive regulation of Schwann cell differentiation;GO:0014070,biological_process response to organic cyclic compound;GO:0016032,biological_process viral process;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0031490,molecular_function chromatin DNA binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0032403,molecular_function protein complex binding;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032495,biological_process response to muramyl dipeptide;GO:0032496,biological_process response to lipopolysaccharide;GO:0032570,biological_process response to progesterone;GO:0032868,biological_process response to insulin;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0033256,cellular_component I-kappaB/NF-kappaB complex;GO:0033590,biological_process response to cobalamin;GO:0033613,molecular_function activating transcription factor binding;GO:0034097,biological_process response to cytokine;GO:0035525,cellular_component NF-kappaB p50/p65 complex;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0035994,biological_process response to muscle stretch;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042301,molecular_function phosphate ion binding;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042805,molecular_function actinin binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043200,biological_process response to amino acid;GO:0043234,cellular_component protein complex;GO:0043278,biological_process response to morphine;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043620,biological_process regulation of DNA-templated transcription in response to stress;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045084,biological_process positive regulation of interleukin-12 biosynthetic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0050727,biological_process regulation of inflammatory response;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050862,biological_process positive regulation of T cell receptor signaling pathway;GO:0051059,molecular_function NF-kappaB binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051591,biological_process response to cAMP;GO:0051607,biological_process defense response to virus;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070431,biological_process nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070491,molecular_function repressing transcription factor binding;GO:0070555,biological_process response to interleukin-1;GO:0071159,cellular_component NF-kappaB complex;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071223,biological_process cellular response to lipoteichoic acid;GO:0071224,biological_process cellular response to peptidoglycan;GO:0071316,biological_process cellular response to nicotine;GO:0071347,biological_process cellular response to interleukin-1;GO:0071354,biological_process cellular response to interleukin-6;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071532,molecular_function ankyrin repeat binding;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling;GO:1901223,biological_process negative regulation of NIK/NF-kappaB signaling;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1901522,biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:2000630,biological_process positive regulation of miRNA metabolic process;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	RELA; transcription factor p65; K04735	RELA proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol%3BAcc:HGNC:9955]
ENSG00000102316	125.71	140.51	116.56	106.21	127.07	114.61	0.148932357959021	7.79164858880544	0.0734414901735954	0.364797606052357	X:54807598-54816012:+	MAGED2	10;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0007565,biological_process female pregnancy;GO:0016020,cellular_component membrane;GO:0031093,cellular_component platelet alpha granule lumen;GO:0070294,biological_process renal sodium ion absorption	NA	MAGE family member D2 [Source:HGNC Symbol%3BAcc:HGNC:16353]
ENSG00000054116	77.81	84.57	80.66	72.66	76.40	76.02	0.11953789175347	5.72860503726063	0.0734734592560285	0.364810419898032	1:36136569-36156053:-	TRAPPC3	14;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048193,biological_process Golgi vesicle transport;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 3 [Source:HGNC Symbol%3BAcc:HGNC:19942]
ENSG00000104866	28.01	29.60	27.52	25.75	27.11	26.12	0.117353433507193	5.82845110393624	0.0736126201671005	0.365211568289643	19:45091395-45148077:+	PPP1R37	4;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019902,molecular_function phosphatase binding	NA	protein phosphatase 1 regulatory subunit 37 [Source:HGNC Symbol%3BAcc:HGNC:27607]
ENSG00000112118	34.87	39.03	32.49	41.46	37.89	38.55	-0.138871183668842	6.66898810683603	0.0736304763392485	0.365211568289643	6:52264008-52284881:-	MCM3	19;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005658,cellular_component alpha DNA polymerase:primase complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0042555,cellular_component MCM complex;GO:0048471,cellular_component perinuclear region of cytoplasm	MCM3; DNA replication licensing factor MCM3 [EC:3.6.4.12]; K02541	minichromosome maintenance complex component 3 [Source:HGNC Symbol%3BAcc:HGNC:6945]
ENSG00000182612	6.19	5.84	4.74	3.96	5.77	3.49	0.357512949163762	2.6241936288776	0.0736425163481009	0.365211568289643	17:81637170-81648749:+	TSPAN10	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	tetraspanin 10 [Source:HGNC Symbol%3BAcc:HGNC:29942]
ENSG00000213585	255.47	293.90	245.08	296.84	308.37	276.55	-0.139765381326884	7.89111695880103	0.0738282665097042	0.365746649827001	5:133971914-134005133:-	VDAC1	38;GO:0001662,biological_process behavioral fear response;GO:0005253,molecular_function anion channel activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0006915,biological_process apoptotic process;GO:0007268,biological_process chemical synaptic transmission;GO:0007270,biological_process neuron-neuron synaptic transmission;GO:0007612,biological_process learning;GO:0008021,cellular_component synaptic vesicle;GO:0008308,molecular_function voltage-gated anion channel activity;GO:0015288,molecular_function porin activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016236,biological_process macroautophagy;GO:0019901,molecular_function protein kinase binding;GO:0030855,biological_process epithelial cell differentiation;GO:0032403,molecular_function protein complex binding;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0045121,cellular_component membrane raft;GO:0046930,cellular_component pore complex;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0098656,biological_process anion transmembrane transport;GO:1903146,biological_process regulation of mitophagy;GO:1903959,biological_process regulation of anion transmembrane transport;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	VDAC1; voltage-dependent anion channel protein 1; K05862	voltage dependent anion channel 1 [Source:HGNC Symbol%3BAcc:HGNC:12669]
ENSG00000167114	5.13	5.66	5.20	4.02	5.43	4.02	0.255474779565899	3.31858819874005	0.073847145874645	0.365746649827001	9:128340645-128361470:+	SLC27A4	27;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0000166,molecular_function nucleotide binding;GO:0001579,biological_process medium-chain fatty acid transport;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0015245,molecular_function fatty acid transporter activity;GO:0015908,biological_process fatty acid transport;GO:0015909,biological_process long-chain fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0031526,cellular_component brush border membrane;GO:0031957,molecular_function very long-chain fatty acid-CoA ligase activity;GO:0042760,biological_process very long-chain fatty acid catabolic process;GO:0043588,biological_process skin development;GO:0044539,biological_process long-chain fatty acid import	SLC27A1_4, FATP1, FATP4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]; K08745	solute carrier family 27 member 4 [Source:HGNC Symbol%3BAcc:HGNC:10998]
ENSG00000183421	30.81	23.59	31.73	35.76	28.56	34.79	-0.187932971640836	6.27517627969934	0.0738533804928116	0.365746649827001	21:41739368-41767106:-	RIPK4	13;GO:0000166,molecular_function nucleotide binding;GO:0002009,biological_process morphogenesis of an epithelium;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	NA	receptor interacting serine/threonine kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:496]
ENSG00000132670	47.03	46.27	46.53	48.79	51.89	51.61	-0.111244848272618	6.87515595337089	0.0738787036749813	0.365746649827001	20:2864183-3039076:+	PTPRA	22;GO:0000165,biological_process MAPK cascade;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006470,biological_process protein dephosphorylation;GO:0007411,biological_process axon guidance;GO:0008286,biological_process insulin receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043235,cellular_component receptor complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070062,cellular_component extracellular exosome	NA	protein tyrosine phosphatase%2C receptor type A [Source:HGNC Symbol%3BAcc:HGNC:9664]
ENSG00000038358	13.54	12.94	14.31	14.77	14.87	15.01	-0.116100599351474	5.90906875597429	0.0739055053430355	0.365746649827001	16:67873022-67884503:+	EDC4	10;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0031087,biological_process deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	EDC4; enhancer of mRNA-decapping protein 4; K12616	enhancer of mRNA decapping 4 [Source:HGNC Symbol%3BAcc:HGNC:17157]
ENSG00000102882	61.45	60.00	67.51	58.89	60.29	55.54	0.126727705026766	6.19949752086698	0.0739579871946065	0.365746649827001	16:30114104-30123506:-	MAPK3	106;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0000189,biological_process MAPK import into nucleus;GO:0001784,molecular_function phosphotyrosine binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002741,biological_process positive regulation of cytokine secretion involved in immune response;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006461,biological_process protein complex assembly;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007411,biological_process axon guidance;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009636,biological_process response to toxic substance;GO:0009887,biological_process organ morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0010759,biological_process positive regulation of macrophage chemotaxis;GO:0014032,biological_process neural crest cell development;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019233,biological_process sensory perception of pain;GO:0019369,biological_process arachidonic acid metabolic process;GO:0019902,molecular_function phosphatase binding;GO:0030168,biological_process platelet activation;GO:0030278,biological_process regulation of ossification;GO:0030509,biological_process BMP signaling pathway;GO:0030641,biological_process regulation of cellular pH;GO:0030878,biological_process thyroid gland development;GO:0031143,cellular_component pseudopodium;GO:0031281,biological_process positive regulation of cyclase activity;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032496,biological_process response to lipopolysaccharide;GO:0032872,biological_process regulation of stress-activated MAPK cascade;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035556,biological_process intracellular signal transduction;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042473,biological_process outer ear morphogenesis;GO:0043234,cellular_component protein complex;GO:0043330,biological_process response to exogenous dsRNA;GO:0045727,biological_process positive regulation of translation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048538,biological_process thymus development;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051216,biological_process cartilage development;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060324,biological_process face development;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway;GO:0060425,biological_process lung morphogenesis;GO:0060440,biological_process trachea formation;GO:0061308,biological_process cardiac neural crest cell development involved in heart development;GO:0070062,cellular_component extracellular exosome;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0070849,biological_process response to epidermal growth factor;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071276,biological_process cellular response to cadmium ion;GO:0072584,biological_process caveolin-mediated endocytosis;GO:0090170,biological_process regulation of Golgi inheritance;GO:0097110,molecular_function scaffold protein binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1903351,biological_process cellular response to dopamine;GO:1904355,biological_process positive regulation of telomere capping;GO:1904417,biological_process positive regulation of xenophagy;GO:1905050,biological_process positive regulation of metallopeptidase activity;GO:2000641,biological_process regulation of early endosome to late endosome transport;GO:2000657,biological_process negative regulation of apolipoprotein binding	ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]; K04371	mitogen-activated protein kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:6877]
ENSG00000164611	115.70	134.87	119.56	146.14	144.28	123.23	-0.150536879180953	6.57149541248018	0.0739810930278888	0.365746649827001	5:160421821-160428744:+	PTTG1	25;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007283,biological_process spermatogenesis;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0045143,biological_process homologous chromosome segregation;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:2000816,biological_process negative regulation of mitotic sister chromatid separation	PTTG; securin; K06635	pituitary tumor-transforming 1 [Source:HGNC Symbol%3BAcc:HGNC:9690]
ENSG00000255302	138.23	152.80	140.90	129.06	141.95	127.48	0.126110934417912	6.28093646530959	0.0739861304854265	0.365746649827001	15:48877885-48880183:+	EID1	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0030154,biological_process cell differentiation;GO:0035034,molecular_function histone acetyltransferase regulator activity;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035065,biological_process regulation of histone acetylation;GO:0045595,biological_process regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	EP300 interacting inhibitor of differentiation 1 [Source:HGNC Symbol%3BAcc:HGNC:1191]
ENSG00000115568	4.54	4.42	4.21	5.14	4.72	4.84	-0.146756900071228	4.7275365927605	0.0740577049049671	0.365767689188591	2:218637915-218659655:-	ZNF142	9;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 142 [Source:HGNC Symbol%3BAcc:HGNC:12927]
ENSG00000160606	13.43	9.51	11.96	9.90	11.08	7.97	0.295575994738398	3.10985513920361	0.0740792518919323	0.365767689188591	17:28724347-28727935:-	TLCD1	3;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	TLC domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25177]
ENSG00000138698	26.96	29.12	28.10	31.87	29.66	30.58	-0.120444754831102	5.9174476944193	0.0740962431805721	0.365767689188591	4:98261383-98443861:+	RAP1GDS1	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0014829,biological_process vascular smooth muscle contraction;GO:0031034,biological_process myosin filament assembly;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0070062,cellular_component extracellular exosome	NA	Rap1 GTPase-GDP dissociation stimulator 1 [Source:HGNC Symbol%3BAcc:HGNC:9859]
ENSG00000162496	31.03	24.16	29.41	33.06	29.30	34.38	-0.174514906497937	4.79011212997759	0.0741082525021596	0.365767689188591	1:12567909-12617731:-	DHRS3	19;GO:0000166,molecular_function nucleotide binding;GO:0001523,biological_process retinoid metabolic process;GO:0003151,biological_process outflow tract morphogenesis;GO:0004745,molecular_function retinol dehydrogenase activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007601,biological_process visual perception;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030278,biological_process regulation of ossification;GO:0042572,biological_process retinol metabolic process;GO:0042622,cellular_component photoreceptor outer segment membrane;GO:0048387,biological_process negative regulation of retinoic acid receptor signaling pathway;GO:0052650,molecular_function NADP-retinol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060021,biological_process palate development;GO:0060349,biological_process bone morphogenesis;GO:0060411,biological_process cardiac septum morphogenesis	DHRS3; short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]; K11146	dehydrogenase/reductase 3 [Source:HGNC Symbol%3BAcc:HGNC:17693]
ENSG00000130517	22.30	24.75	26.02	25.65	28.78	27.81	-0.160772793365391	4.70947690431974	0.0741503648596939	0.365786187570151	19:18340586-18369950:+	PGPEP1	7;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016920,molecular_function pyroglutamyl-peptidase activity	NA	pyroglutamyl-peptidase I [Source:HGNC Symbol%3BAcc:HGNC:13568]
ENSG00000137809	0.36	0.19	0.43	0.80	0.26	0.53	-0.65220714856511	0.772420123876975	0.0741709364467952	0.365786187570151	15:68296532-68432162:-	ITGA11	19;GO:0001649,biological_process osteoblast differentiation;GO:0005518,molecular_function collagen binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006929,biological_process substrate-dependent cell migration;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007517,biological_process muscle organ development;GO:0008305,cellular_component integrin complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0034681,cellular_component integrin alpha11-beta1 complex;GO:0038064,molecular_function collagen receptor activity;GO:0038065,biological_process collagen-activated signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0098639,molecular_function collagen binding involved in cell-matrix adhesion	ITGA11; integrin alpha 11; K06587	integrin subunit alpha 11 [Source:HGNC Symbol%3BAcc:HGNC:6136]
ENSG00000059588	11.05	10.69	9.72	9.27	10.00	9.70	0.130113478907801	5.61840324484723	0.07429228920858	0.366239152480581	1:234391312-234479103:-	TARBP1	12;GO:0000453,biological_process enzyme-directed rRNA 2'-O-methylation;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006396,biological_process RNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0016423,molecular_function tRNA (guanine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0070039,molecular_function rRNA (guanosine-2'-O-)-methyltransferase activity	NA	TAR (HIV-1) RNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11568]
ENSG00000152104	22.77	21.50	24.78	26.45	23.70	26.11	-0.129849727088602	6.4350676348471	0.0743801663496083	0.366289580485398	1:214348695-214552449:-	PTPN14	19;GO:0001946,biological_process lymphangiogenesis;GO:0003712,molecular_function transcription cofactor activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006470,biological_process protein dephosphorylation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0046825,biological_process regulation of protein export from nucleus	NA	protein tyrosine phosphatase%2C non-receptor type 14 [Source:HGNC Symbol%3BAcc:HGNC:9647]
ENSG00000177602	3.98	5.19	4.52	4.53	6.72	5.38	-0.275692507768925	3.61173472808596	0.0743842622057927	0.366289580485398	17:3723902-3726699:+	HASPIN	23;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0071459,biological_process protein localization to chromosome, centromeric region;GO:0072354,molecular_function histone kinase activity (H3-T3 specific);GO:0090231,biological_process regulation of spindle checkpoint;GO:2000751,biological_process histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore	NA	histone H3 associated protein kinase [Source:HGNC Symbol%3BAcc:HGNC:19682]
ENSG00000185896	182.41	182.42	179.86	165.48	173.03	172.11	0.1048461726891	7.7834460294163	0.0744439655751531	0.366289580485398	13:113297240-113323672:+	LAMP1	46;GO:0001618,molecular_function virus receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005773,cellular_component vacuole;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0008021,cellular_component synaptic vesicle;GO:0008626,biological_process granzyme-mediated apoptotic signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0035577,cellular_component azurophil granule membrane;GO:0042383,cellular_component sarcolemma;GO:0042470,cellular_component melanosome;GO:0043025,cellular_component neuronal cell body;GO:0043312,biological_process neutrophil degranulation;GO:0043323,biological_process positive regulation of natural killer cell degranulation;GO:0044194,cellular_component cytolytic granule;GO:0044754,cellular_component autolysosome;GO:0045335,cellular_component phagocytic vesicle;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0046718,biological_process viral entry into host cell;GO:0048102,biological_process autophagic cell death;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0061474,cellular_component phagolysosome membrane;GO:0070062,cellular_component extracellular exosome;GO:0072594,biological_process establishment of protein localization to organelle;GO:0090160,biological_process Golgi to lysosome transport;GO:0097208,cellular_component alveolar lamellar body;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1902513,biological_process regulation of organelle transport along microtubule	LAMP1_2, CD107; lysosomal-associated membrane protein 1/2; K06528	lysosomal associated membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6499]
ENSG00000111540	48.21	61.54	52.11	50.11	48.34	47.16	0.157947143915616	5.26576722112986	0.0744475672896832	0.366289580485398	12:55973912-55996683:+	RAB5B	25;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007032,biological_process endosome organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0019882,biological_process antigen processing and presentation;GO:0030100,biological_process regulation of endocytosis;GO:0030139,cellular_component endocytic vesicle;GO:0030667,cellular_component secretory granule membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031901,cellular_component early endosome membrane;GO:0042470,cellular_component melanosome;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0048227,biological_process plasma membrane to endosome transport;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	RAB5B; Ras-related protein Rab-5B; K07888	RAB5B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9784]
ENSG00000135845	27.66	28.74	26.02	23.78	24.51	26.28	0.151548238951153	4.55099675709219	0.0744500613521839	0.366289580485398	1:172370188-172444086:-	PIGC	11;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0003824,molecular_function catalytic activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0017176,molecular_function phosphatidylinositol N-acetylglucosaminyltransferase activity	PIGC, GPI2; phosphatidylinositol N-acetylglucosaminyltransferase subunit C; K03859	phosphatidylinositol glycan anchor biosynthesis class C [Source:HGNC Symbol%3BAcc:HGNC:8960]
ENSG00000158089	66.52	67.71	64.80	68.78	79.19	70.77	-0.124863793563481	7.01630610473508	0.0744896482791014	0.366333495684324	2:30910466-31155202:-	GALNT14	11;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 14 [Source:HGNC Symbol%3BAcc:HGNC:22946]
ENSG00000284691	11.61	11.37	12.09	8.32	12.22	7.92	0.317235469803302	2.78622958620747	0.0745327457996834	0.366333495684324	7:150400701-150412470:+	AC073111.5	1;GO:0003676,molecular_function nucleic acid binding	NA	NA
ENSG00000167110	36.84	35.13	35.38	31.53	33.95	34.46	0.115355134897038	6.78114993841868	0.074547523571949	0.366333495684324	9:128255828-128275995:-	GOLGA2	38;GO:0000137,cellular_component Golgi cis cisterna;GO:0000139,cellular_component Golgi membrane;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006486,biological_process protein glycosylation;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007020,biological_process microtubule nucleation;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0008017,molecular_function microtubule binding;GO:0008356,biological_process asymmetric cell division;GO:0010507,biological_process negative regulation of autophagy;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0019905,molecular_function syntaxin binding;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0032091,biological_process negative regulation of protein binding;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0045296,molecular_function cadherin binding;GO:0048208,biological_process COPII vesicle coating;GO:0051225,biological_process spindle assembly;GO:0051289,biological_process protein homotetramerization;GO:0051301,biological_process cell division;GO:0060050,biological_process positive regulation of protein glycosylation;GO:0061676,molecular_function importin-alpha family protein binding;GO:0072686,cellular_component mitotic spindle;GO:0090161,biological_process Golgi ribbon formation;GO:0090166,biological_process Golgi disassembly;GO:0090306,biological_process spindle assembly involved in meiosis;GO:0090307,biological_process mitotic spindle assembly;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	NA	golgin A2 [Source:HGNC Symbol%3BAcc:HGNC:4425]
ENSG00000240204	6.52	4.41	6.79	8.06	7.39	11.18	-0.551519486572557	0.695824171610456	0.0746464333707712	0.366674387586618	7:129502478-129512932:+	SMKR1	NA	NA	small lysine rich protein 1 [Source:HGNC Symbol%3BAcc:HGNC:43561]
ENSG00000168026	2.98	3.44	3.76	2.93	2.80	3.12	0.20730000478682	3.70026704847114	0.0747282656630082	0.366931155725839	3:39107703-39138903:+	TTC21A	5;GO:0005515,molecular_function protein binding;GO:0005929,cellular_component cilium;GO:0030991,cellular_component intraciliary transport particle A;GO:0035721,biological_process intraciliary retrograde transport;GO:0061512,biological_process protein localization to cilium	NA	tetratricopeptide repeat domain 21A [Source:HGNC Symbol%3BAcc:HGNC:30761]
ENSG00000167889	2.39	2.93	2.58	2.12	2.45	1.96	0.281078715781609	2.60079406541449	0.074826454801942	0.367268004530054	17:76868455-76950393:+	MGAT5B	11;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030144,molecular_function alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity;GO:0046872,molecular_function metal ion binding	MGAT5B; mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B [EC:2.4.1.-]; K09661	mannosyl (alpha-1%2C6-)-glycoprotein beta-1%2C6-N-acetyl-glucosaminyltransferase%2C isozyme B [Source:HGNC Symbol%3BAcc:HGNC:24140]
ENSG00000170954	2.65	2.79	2.89	3.72	3.64	2.79	-0.271045955201125	2.85221157129677	0.0748861092311261	0.367415523275086	19:53107878-53133077:-	ZNF415	12;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0015630,cellular_component microtubule cytoskeleton;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 415 [Source:HGNC Symbol%3BAcc:HGNC:20636]
ENSG00000171757	3.35	2.20	3.12	4.20	4.20	2.98	-0.356570383662275	2.27650739347668	0.0750121600437519	0.367888558918646	3:169793427-169812986:-	LRRC34	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	leucine rich repeat containing 34 [Source:HGNC Symbol%3BAcc:HGNC:28408]
ENSG00000115738	83.45	70.84	88.25	75.43	72.64	71.72	0.161005853315767	4.96351362458609	0.0750876497916293	0.368113347892375	2:8678844-8684453:+	ID2	35;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0019216,biological_process regulation of lipid metabolic process;GO:0032922,biological_process circadian regulation of gene expression;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0042752,biological_process regulation of circadian rhythm;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043234,cellular_component protein complex;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0044325,molecular_function ion channel binding;GO:0045475,biological_process locomotor rhythm;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045777,biological_process positive regulation of blood pressure;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048663,biological_process neuron fate commitment;GO:0060749,biological_process mammary gland alveolus development;GO:0061030,biological_process epithelial cell differentiation involved in mammary gland alveolus development;GO:0061031,biological_process endodermal digestive tract morphogenesis;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071931,biological_process positive regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0090398,biological_process cellular senescence;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle;GO:2000178,biological_process negative regulation of neural precursor cell proliferation	ID1; DNA-binding protein inhibitor ID1; K04680	inhibitor of DNA binding 2%2C HLH protein [Source:HGNC Symbol%3BAcc:HGNC:5361]
ENSG00000182054	140.57	174.43	145.14	130.31	155.77	126.12	0.169651518157324	7.62400090960202	0.0751862828047794	0.368412279397528	15:90083044-90102504:-	IDH2	24;GO:0000287,molecular_function magnesium ion binding;GO:0004448,molecular_function isocitrate dehydrogenase activity;GO:0004450,molecular_function isocitrate dehydrogenase (NADP+) activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006097,biological_process glyoxylate cycle;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006102,biological_process isocitrate metabolic process;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006741,biological_process NADP biosynthetic process;GO:0007005,biological_process mitochondrion organization;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0046872,molecular_function metal ion binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0060253,biological_process negative regulation of glial cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:1903976,biological_process negative regulation of glial cell migration;GO:1904465,biological_process negative regulation of matrix metallopeptidase secretion	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]; K00031	isocitrate dehydrogenase (NADP(+)) 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:5383]
ENSG00000101407	11.19	11.48	10.64	12.00	11.91	12.77	-0.130213918068706	5.26780934605418	0.0752125059302895	0.368412279397528	20:37983006-38033468:-	TTI1	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0031931,cellular_component TORC1 complex;GO:0031932,cellular_component TORC2 complex;GO:0032006,biological_process regulation of TOR signaling	NA	TELO2 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29029]
ENSG00000240065	77.72	50.62	73.94	86.04	66.38	88.94	-0.238993849797464	5.61465021798573	0.0752462762138773	0.368412279397528	6:32844135-32859585:+	PSMB9	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1990111,cellular_component spermatoproteasome complex;GO:2000116,biological_process regulation of cysteine-type endopeptidase activity	PSMB9, LMP2; 20S proteasome subunit beta 9 [EC:3.4.25.1]; K02741	proteasome subunit beta 9 [Source:HGNC Symbol%3BAcc:HGNC:9546]
ENSG00000161960	485.02	526.39	503.11	554.46	548.74	540.52	-0.106514911047501	9.66300203304376	0.0752673439581189	0.368412279397528	17:7572705-7579005:+	EIF4A1	25;GO:0000166,molecular_function nucleotide binding;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000339,molecular_function RNA cap binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0010468,biological_process regulation of gene expression;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex;GO:0016787,molecular_function hydrolase activity;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	EIF4A; translation initiation factor 4A; K03257	eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol%3BAcc:HGNC:3282]
ENSG00000078177	1.77	1.26	1.61	2.03	1.79	1.79	-0.243912778187761	3.23676987248656	0.0753500987223569	0.368432739992462	4:40056825-40158252:+	N4BP2	10;GO:0000166,molecular_function nucleotide binding;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016310,biological_process phosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0046404,molecular_function ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	NEDD4 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:29851]
ENSG00000126217	1.00	0.69	1.02	1.17	1.14	1.11	-0.300379751616005	2.4088254165012	0.0753866403373344	0.368432739992462	13:112894377-113099739:+	MCF2L	16;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008289,molecular_function lipid binding;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	MCF.2 cell line derived transforming sequence like [Source:HGNC Symbol%3BAcc:HGNC:14576]
ENSG00000166508	88.76	84.76	81.58	96.87	85.86	97.27	-0.12258586364109	7.59059857064182	0.0754129385477603	0.368432739992462	7:100092727-100101940:-	MCM7	29;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003697,molecular_function single-stranded DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0042325,biological_process regulation of phosphorylation;GO:0042493,biological_process response to drug;GO:0042555,cellular_component MCM complex;GO:0071310,biological_process cellular response to organic substance;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071466,biological_process cellular response to xenobiotic stimulus	MCM7, CDC47; DNA replication licensing factor MCM7 [EC:3.6.4.12]; K02210	minichromosome maintenance complex component 7 [Source:HGNC Symbol%3BAcc:HGNC:6950]
ENSG00000138363	56.12	53.74	52.15	60.57	56.55	59.78	-0.11503208473229	6.78058812528542	0.0754562713716499	0.368432739992462	2:215311816-215349773:+	ATIC	25;GO:0003360,biological_process brainstem development;GO:0003824,molecular_function catalytic activity;GO:0003937,molecular_function IMP cyclohydrolase activity;GO:0004643,molecular_function phosphoribosylaminoimidazolecarboxamide formyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006189,biological_process 'de novo' IMP biosynthetic process;GO:0008152,biological_process metabolic process;GO:0009116,biological_process nucleoside metabolic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0009259,biological_process ribonucleotide metabolic process;GO:0010035,biological_process response to inorganic substance;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0021549,biological_process cerebellum development;GO:0021987,biological_process cerebral cortex development;GO:0031100,biological_process organ regeneration;GO:0042803,molecular_function protein homodimerization activity;GO:0045296,molecular_function cadherin binding;GO:0046452,biological_process dihydrofolate metabolic process;GO:0046654,biological_process tetrahydrofolate biosynthetic process;GO:0070062,cellular_component extracellular exosome	purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]; K00602	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Source:HGNC Symbol%3BAcc:HGNC:794]
ENSG00000129195	33.32	36.36	29.52	36.87	40.31	34.70	-0.166204758868513	5.02201523069223	0.0754712186376366	0.368432739992462	17:6444414-6451469:+	PIMREG	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0051301,biological_process cell division	NA	PICALM interacting mitotic regulator [Source:HGNC Symbol%3BAcc:HGNC:25483]
ENSG00000172164	135.21	108.47	138.08	145.24	132.61	150.87	-0.154373398907984	7.77123969911919	0.0754773906949072	0.368432739992462	8:120535744-120813273:-	SNTB1	16;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006936,biological_process muscle contraction;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0042383,cellular_component sarcolemma;GO:0043234,cellular_component protein complex;GO:0045202,cellular_component synapse	NA	syntrophin beta 1 [Source:HGNC Symbol%3BAcc:HGNC:11168]
ENSG00000144746	197.12	219.72	181.99	177.26	191.89	180.31	0.134327390056719	7.1314899431156	0.0754792924998656	0.368432739992462	3:69084943-69106066:+	ARL6IP5	17;GO:0002037,biological_process negative regulation of L-glutamate transport;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010917,biological_process negative regulation of mitochondrial membrane potential;GO:0015813,biological_process L-glutamate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070062,cellular_component extracellular exosome	NA	ADP ribosylation factor like GTPase 6 interacting protein 5 [Source:HGNC Symbol%3BAcc:HGNC:16937]
ENSG00000119812	31.09	33.19	26.84	24.41	30.64	26.44	0.170408121937489	5.53039349328357	0.0755403787436204	0.368585975371289	2:33583657-33599382:-	FAM98A	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0006479,biological_process protein methylation;GO:0008276,molecular_function protein methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0072669,cellular_component tRNA-splicing ligase complex	NA	family with sequence similarity 98 member A [Source:HGNC Symbol%3BAcc:HGNC:24520]
ENSG00000143570	100.63	111.20	106.84	96.90	100.11	98.97	0.116702853122149	6.63984802461438	0.0755761371101285	0.368615555971719	1:153959098-153968184:-	SLC39A1	19;GO:0001701,biological_process in utero embryonic development;GO:0005102,molecular_function receptor binding;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006829,biological_process zinc II ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022890,molecular_function inorganic cation transmembrane transporter activity;GO:0030001,biological_process metal ion transport;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0055085,biological_process transmembrane transport;GO:0060173,biological_process limb development;GO:0071577,biological_process zinc II ion transmembrane transport	NA	solute carrier family 39 member 1 [Source:HGNC Symbol%3BAcc:HGNC:12876]
ENSG00000171970	3.05	3.47	3.69	3.80	4.81	3.89	-0.280285907049687	2.74976003017517	0.0756722126569988	0.36891356350419	19:2900897-2918476:+	ZNF57	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 57 [Source:HGNC Symbol%3BAcc:HGNC:13125]
ENSG00000187778	40.45	39.80	38.07	41.54	45.13	42.74	-0.117696870501718	6.02108166786606	0.0756966765685307	0.36891356350419	12:49556543-49568153:-	MCRS1	30;GO:0000123,cellular_component histone acetyltransferase complex;GO:0002151,molecular_function G-quadruplex RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005844,cellular_component polysome;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006464,biological_process cellular protein modification process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008266,molecular_function poly(U) RNA binding;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0030425,cellular_component dendrite;GO:0031011,cellular_component Ino80 complex;GO:0034046,molecular_function poly(G) binding;GO:0043204,cellular_component perikaryon;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific);GO:0071339,cellular_component MLL1 complex;GO:1904751,biological_process positive regulation of protein localization to nucleolus	NA	microspherule protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6960]
ENSG00000102921	13.82	12.44	13.85	14.21	14.67	15.57	-0.131840753633874	5.25293999095579	0.0758330915893822	0.369379386007859	16:48538725-48620148:-	N4BP1	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0016605,cellular_component PML body;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034644,biological_process cellular response to UV	NA	NEDD4 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29850]
ENSG00000007545	4.80	3.97	4.29	3.95	3.81	3.88	0.186565737862087	3.98721729523103	0.0758701226784988	0.369379386007859	16:1612324-1677908:+	CRAMP1	3;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus	NA	cramped chromatin regulator homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:14122]
ENSG00000171817	0.50	0.34	0.45	0.87	0.61	0.57	-0.630859716486447	0.34044224902049	0.0758815301957658	0.369379386007859	19:37551405-37614097:+	ZNF540	16;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0017148,biological_process negative regulation of translation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 540 [Source:HGNC Symbol%3BAcc:HGNC:25331]
ENSG00000119705	40.66	38.97	34.36	45.59	40.02	43.46	-0.169111197782877	4.468422719492	0.0759267689255582	0.369454716845533	14:77708070-77761104:+	SLIRP	17;GO:0000961,biological_process negative regulation of mitochondrial RNA catabolic process;GO:0001669,cellular_component acrosomal vesicle;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007286,biological_process spermatid development;GO:0007338,biological_process single fertilization;GO:0030317,biological_process sperm motility;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0036126,cellular_component sperm flagellum;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070584,biological_process mitochondrion morphogenesis	NA	SRA stem-loop interacting RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:20495]
ENSG00000065882	16.15	17.83	16.24	18.28	18.38	18.24	-0.120243791557613	6.08679884235717	0.0760538513061345	0.369928078472981	4:37891086-38139175:+	TBC1D1	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0032880,biological_process regulation of protein localization;GO:0061024,biological_process membrane organization;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 1 [Source:HGNC Symbol%3BAcc:HGNC:11578]
ENSG00000166016	8.82	9.26	9.84	10.79	9.74	10.59	-0.145490315326144	4.92835654851744	0.0761316209933969	0.370161304892689	11:34150987-34358008:-	ABTB2	10;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0097237,biological_process cellular response to toxic substance	NA	ankyrin repeat and BTB domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:23842]
ENSG00000149743	27.15	22.31	25.52	23.40	18.33	24.05	0.205026443146859	4.32954968550378	0.0761999957094088	0.370348687055948	11:64223798-64226254:-	TRPT1	7;GO:0000215,molecular_function tRNA 2'-phosphotransferase activity;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0008033,biological_process tRNA processing;GO:0008665,molecular_function 2'-phosphotransferase activity;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0045859,biological_process regulation of protein kinase activity	NA	tRNA phosphotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:20316]
ENSG00000150782	19.03	18.49	16.02	21.60	18.21	23.56	-0.235508751350025	3.51895913440331	0.0762798619363677	0.370591751943692	11:112143250-112164117:-	IL18	45;GO:0000165,biological_process MAPK cascade;GO:0001525,biological_process angiogenesis;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007267,biological_process cell-cell signaling;GO:0010628,biological_process positive regulation of gene expression;GO:0010744,biological_process positive regulation of macrophage derived foam cell differentiation;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030101,biological_process natural killer cell activation;GO:0030155,biological_process regulation of cell adhesion;GO:0030431,biological_process sleep;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032148,biological_process activation of protein kinase B activity;GO:0032725,biological_process positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032740,biological_process positive regulation of interleukin-17 production;GO:0032819,biological_process positive regulation of natural killer cell proliferation;GO:0034105,biological_process positive regulation of tissue remodeling;GO:0035655,biological_process interleukin-18-mediated signaling pathway;GO:0042033,biological_process chemokine biosynthetic process;GO:0042088,biological_process T-helper 1 type immune response;GO:0042092,biological_process type 2 immune response;GO:0042094,biological_process interleukin-2 biosynthetic process;GO:0042095,biological_process interferon-gamma biosynthetic process;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0042231,biological_process interleukin-13 biosynthetic process;GO:0042253,biological_process granulocyte macrophage colony-stimulating factor biosynthetic process;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042632,biological_process cholesterol homeostasis;GO:0045630,biological_process positive regulation of T-helper 2 cell differentiation;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051142,biological_process positive regulation of NK T cell proliferation;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome;GO:0070328,biological_process triglyceride homeostasis;GO:0071407,biological_process cellular response to organic cyclic compound	IL18, IL1F4; interleukin 18; K05482	interleukin 18 [Source:HGNC Symbol%3BAcc:HGNC:5986]
ENSG00000180817	74.51	86.55	70.79	72.52	70.39	68.97	0.137678526282783	6.04183038232004	0.0766367458106202	0.372061290400883	10:70202829-70233911:-	PPA1	11;GO:0000287,molecular_function magnesium ion binding;GO:0004427,molecular_function inorganic diphosphatase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0016462,molecular_function pyrophosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071344,biological_process diphosphate metabolic process	ppa; inorganic pyrophosphatase [EC:3.6.1.1]; K01507	pyrophosphatase (inorganic) 1 [Source:HGNC Symbol%3BAcc:HGNC:9226]
ENSG00000105048	119.90	110.49	123.00	109.81	105.56	113.22	0.118147876253502	6.96280703596627	0.0766438176930476	0.372061290400883	19:55132793-55149354:-	TNNT1	11;GO:0003009,biological_process skeletal muscle contraction;GO:0005515,molecular_function protein binding;GO:0005523,molecular_function tropomyosin binding;GO:0005829,cellular_component cytosol;GO:0005861,cellular_component troponin complex;GO:0006937,biological_process regulation of muscle contraction;GO:0014883,biological_process transition between fast and slow fiber;GO:0030049,biological_process muscle filament sliding;GO:0031014,molecular_function troponin T binding;GO:0031444,biological_process slow-twitch skeletal muscle fiber contraction;GO:0045932,biological_process negative regulation of muscle contraction	NA	troponin T1%2C slow skeletal type [Source:HGNC Symbol%3BAcc:HGNC:11948]
ENSG00000147955	47.72	52.85	48.19	44.32	47.50	43.94	0.139457800776286	4.99196708203809	0.0766722614070296	0.372061290400883	9:34634721-34637809:-	SIGMAR1	27;GO:0004872,molecular_function receptor activity;GO:0004985,molecular_function opioid receptor activity;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005640,cellular_component nuclear outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0007399,biological_process nervous system development;GO:0008144,molecular_function drug binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030426,cellular_component growth cone;GO:0031410,cellular_component cytoplasmic vesicle;GO:0038003,biological_process opioid receptor signaling pathway;GO:0042995,cellular_component cell projection;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0070207,biological_process protein homotrimerization	NA	sigma non-opioid intracellular receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:8157]
ENSG00000171444	3.84	4.30	4.63	3.63	3.84	3.74	0.198280014220607	3.68199129139207	0.0768266616191204	0.372485957440995	5:113022098-113488830:-	MCC	16;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030027,cellular_component lamellipodium;GO:0042995,cellular_component cell projection;GO:0045184,biological_process establishment of protein localization;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	mutated in colorectal cancers [Source:HGNC Symbol%3BAcc:HGNC:6935]
ENSG00000133627	7.55	10.67	7.04	6.51	6.53	7.68	0.280855627856996	3.27233937100961	0.0768332991824765	0.372485957440995	7:152759748-152855378:+	ACTR3B	12;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0007015,biological_process actin filament organization;GO:0008150,biological_process biological_process;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0042995,cellular_component cell projection;GO:0070062,cellular_component extracellular exosome	NA	ARP3 actin related protein 3 homolog B [Source:HGNC Symbol%3BAcc:HGNC:17256]
ENSG00000143870	473.33	470.60	437.85	429.46	434.84	430.95	0.104956375928756	9.46911855590852	0.0768586425071816	0.372485957440995	2:10783390-10837977:-	PDIA6	23;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0015037,molecular_function peptide disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042470,cellular_component melanosome;GO:0043277,biological_process apoptotic cell clearance;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	PDIA6, TXNDC7; protein disulfide-isomerase A6 [EC:5.3.4.1]; K09584	protein disulfide isomerase family A member 6 [Source:HGNC Symbol%3BAcc:HGNC:30168]
ENSG00000215277	3.37	2.65	1.88	1.91	1.18	2.42	0.524528313135602	1.11496165154342	0.0768938530441217	0.372485957440995	14:23185315-23273477:+	RNF212B	5;GO:0000795,cellular_component synaptonemal complex;GO:0007129,biological_process synapsis;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 212B [Source:HGNC Symbol%3BAcc:HGNC:20438]
ENSG00000164251	16.90	18.21	16.87	13.96	18.15	13.28	0.206465932326624	4.27970903912355	0.0769098130122671	0.372485957440995	5:76818932-76835315:+	F2RL1	68;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0002286,biological_process T cell activation involved in immune response;GO:0002376,biological_process immune system process;GO:0002690,biological_process positive regulation of leukocyte chemotaxis;GO:0002741,biological_process positive regulation of cytokine secretion involved in immune response;GO:0003104,biological_process positive regulation of glomerular filtration;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007596,biological_process blood coagulation;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0015057,molecular_function thrombin receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030193,biological_process regulation of blood coagulation;GO:0030335,biological_process positive regulation of cell migration;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0031143,cellular_component pseudopodium;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0031681,molecular_function G-protein beta-subunit binding;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0034137,biological_process positive regulation of toll-like receptor 2 signaling pathway;GO:0034140,biological_process negative regulation of toll-like receptor 3 signaling pathway;GO:0034141,biological_process positive regulation of toll-like receptor 3 signaling pathway;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035926,biological_process chemokine (C-C motif) ligand 2 secretion;GO:0042119,biological_process neutrophil activation;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043311,biological_process positive regulation of eosinophil degranulation;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046328,biological_process regulation of JNK cascade;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046330,biological_process positive regulation of JNK cascade;GO:0050702,biological_process interleukin-1 beta secretion;GO:0050900,biological_process leukocyte migration;GO:0050921,biological_process positive regulation of chemotaxis;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051607,biological_process defense response to virus;GO:0060100,biological_process positive regulation of phagocytosis, engulfment;GO:0061028,biological_process establishment of endothelial barrier;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070493,biological_process thrombin receptor signaling pathway;GO:0070661,biological_process leukocyte proliferation;GO:0070963,biological_process positive regulation of neutrophil mediated killing of gram-negative bacterium;GO:0072608,biological_process interleukin-10 secretion;GO:0072643,biological_process interferon-gamma secretion;GO:0090195,biological_process chemokine secretion;GO:0090198,biological_process negative regulation of chemokine secretion;GO:0097029,biological_process mature conventional dendritic cell differentiation;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1900135,biological_process positive regulation of renin secretion into blood stream;GO:2000484,biological_process positive regulation of interleukin-8 secretion;GO:2000778,biological_process positive regulation of interleukin-6 secretion	F2RL1, PAR2; coagulation factor II (thrombin) receptor-like 1; K04234	F2R like trypsin receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:3538]
ENSG00000083444	107.66	106.48	108.34	105.43	98.63	97.59	0.108141882525308	7.98120962322993	0.0770108224197721	0.37271035062799	1:11934204-11975538:+	PLOD1	19;GO:0001666,biological_process response to hypoxia;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006464,biological_process cellular protein modification process;GO:0008475,molecular_function procollagen-lysine 5-dioxygenase activity;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0017185,biological_process peptidyl-lysine hydroxylation;GO:0030867,cellular_component rough endoplasmic reticulum membrane;GO:0031418,molecular_function L-ascorbic acid binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0046947,biological_process hydroxylysine biosynthetic process;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [EC:1.14.11.4]; K00473	procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 1 [Source:HGNC Symbol%3BAcc:HGNC:9081]
ENSG00000173230	26.68	27.25	27.03	23.54	26.54	25.41	0.112745095249425	8.00976680692052	0.0770161966777407	0.37271035062799	3:121663198-121749767:-	GOLGB1	15;GO:0000139,cellular_component Golgi membrane;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005801,cellular_component cis-Golgi network;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043565,molecular_function sequence-specific DNA binding;GO:1905793,biological_process protein localization to pericentriolar material	NA	golgin B1 [Source:HGNC Symbol%3BAcc:HGNC:4429]
ENSG00000113658	17.15	17.27	16.52	19.36	18.37	18.85	-0.140956972722163	4.72513880800283	0.0771778426002342	0.373347061651094	5:136132844-136188747:+	SMAD5	43;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001503,biological_process ossification;GO:0001657,biological_process ureteric bud development;GO:0001880,biological_process Mullerian duct regression;GO:0002051,biological_process osteoblast fate commitment;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007281,biological_process germ cell development;GO:0009880,biological_process embryonic pattern specification;GO:0016021,cellular_component integral component of membrane;GO:0017151,molecular_function DEAD/H-box RNA helicase binding;GO:0030218,biological_process erythrocyte differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0030618,molecular_function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043234,cellular_component protein complex;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051216,biological_process cartilage development;GO:0060048,biological_process cardiac muscle contraction;GO:0060348,biological_process bone development;GO:0060395,biological_process SMAD protein signal transduction;GO:0071141,cellular_component SMAD protein complex;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071773,biological_process cellular response to BMP stimulus;GO:1901522,biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	NA	SMAD family member 5 [Source:HGNC Symbol%3BAcc:HGNC:6771]
ENSG00000104142	9.26	10.23	8.93	8.09	9.50	7.92	0.164522389039324	4.79220457107484	0.0773244068378898	0.373910347518008	15:40894429-40903975:+	VPS18	30;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005884,cellular_component actin filament;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006914,biological_process autophagy;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030674,molecular_function protein binding, bridging;GO:0030897,cellular_component HOPS complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0033263,cellular_component CORVET complex;GO:0035542,biological_process regulation of SNARE complex assembly;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding	NA	VPS18%2C CORVET/HOPS core subunit [Source:HGNC Symbol%3BAcc:HGNC:15972]
ENSG00000134827	2.61	2.06	3.06	1.90	1.46	2.49	0.421001006929742	1.63867871670514	0.0773583764379212	0.373928943428316	11:59852799-59866575:-	TCN1	11;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006824,biological_process cobalt ion transport;GO:0009235,biological_process cobalamin metabolic process;GO:0015889,biological_process cobalamin transport;GO:0031419,molecular_function cobalamin binding;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:1904724,cellular_component tertiary granule lumen	NA	transcobalamin 1 [Source:HGNC Symbol%3BAcc:HGNC:11652]
ENSG00000172081	62.49	60.19	68.17	76.94	61.28	77.45	-0.163382075836221	5.47128301392421	0.0773971994841659	0.37397097594276	19:2071037-2096673:-	MOB3A	2;GO:0005622,cellular_component intracellular;GO:0046872,molecular_function metal ion binding	NA	MOB kinase activator 3A [Source:HGNC Symbol%3BAcc:HGNC:29802]
ENSG00000070961	38.37	35.56	38.81	34.61	33.44	36.82	0.117046365030448	7.15668057255037	0.0774558075610646	0.37410853667529	12:89588048-89709300:-	ATP2B1	40;GO:0000166,molecular_function nucleotide binding;GO:0003407,biological_process neural retina development;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007420,biological_process brain development;GO:0007568,biological_process aging;GO:0009409,biological_process response to cold;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0015085,molecular_function calcium ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0030165,molecular_function PDZ domain binding;GO:0032590,cellular_component dendrite membrane;GO:0032591,cellular_component dendritic spine membrane;GO:0032809,cellular_component neuronal cell body membrane;GO:0034220,biological_process ion transmembrane transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045121,cellular_component membrane raft;GO:0045177,cellular_component apical part of cell;GO:0046872,molecular_function metal ion binding;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071305,biological_process cellular response to vitamin D;GO:0071386,biological_process cellular response to corticosterone stimulus;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport;GO:1901660,biological_process calcium ion export;GO:1903779,biological_process regulation of cardiac conduction;GO:1990034,biological_process calcium ion export from cell	ATP2B; P-type Ca2+ transporter type 2B [EC:7.2.2.10]; K05850	ATPase plasma membrane Ca2+ transporting 1 [Source:HGNC Symbol%3BAcc:HGNC:814]
ENSG00000152377	130.20	121.40	125.80	113.19	114.43	124.19	0.113682486383819	7.32503843769373	0.0775642709593542	0.374486696000958	5:136975297-137598379:-	SPOCK1	22;GO:0001558,biological_process regulation of cell growth;GO:0001764,biological_process neuron migration;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0010977,biological_process negative regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016528,cellular_component sarcoplasm;GO:0021953,biological_process central nervous system neuron differentiation;GO:0022008,biological_process neurogenesis;GO:0031594,cellular_component neuromuscular junction;GO:0033268,cellular_component node of Ranvier	NA	SPARC/osteonectin%2C cwcv and kazal like domains proteoglycan 1 [Source:HGNC Symbol%3BAcc:HGNC:11251]
ENSG00000062822	9.82	9.00	9.70	9.89	11.41	10.46	-0.139153574489644	5.11605769777662	0.0776836447382045	0.374917217004406	19:50384203-50418018:+	POLD1	47;GO:0000109,cellular_component nucleotide-excision repair complex;GO:0000166,molecular_function nucleotide binding;GO:0000723,biological_process telomere maintenance;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006287,biological_process base-excision repair, gap-filling;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008296,molecular_function 3'-5'-exodeoxyribonuclease activity;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0009411,biological_process response to UV;GO:0016020,cellular_component membrane;GO:0016235,cellular_component aggresome;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0019985,biological_process translesion synthesis;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034644,biological_process cellular response to UV;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043625,cellular_component delta DNA polymerase complex;GO:0045004,biological_process DNA replication proofreading;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055089,biological_process fatty acid homeostasis;GO:0071897,biological_process DNA biosynthetic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]; K02327	DNA polymerase delta 1%2C catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9175]
ENSG00000101558	274.65	287.45	292.92	304.70	307.03	315.33	-0.105133821072337	8.04796196482435	0.0777435939654978	0.375024295284543	18:9914001-9960021:+	VAPA	34;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007165,biological_process signal transduction;GO:0008017,molecular_function microtubule binding;GO:0008219,biological_process cell death;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0031175,biological_process neuron projection development;GO:0031965,cellular_component nuclear membrane;GO:0031982,cellular_component vesicle;GO:0033149,molecular_function FFAT motif binding;GO:0035577,cellular_component azurophil granule membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043312,biological_process neutrophil degranulation;GO:0044791,biological_process positive regulation by host of viral release from host cell;GO:0044828,biological_process negative regulation by host of viral genome replication;GO:0044829,biological_process positive regulation by host of viral genome replication;GO:0045296,molecular_function cadherin binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061025,biological_process membrane fusion;GO:0070972,biological_process protein localization to endoplasmic reticulum;GO:0090114,biological_process COPII-coated vesicle budding	VAPA; vesicle-associated membrane protein-associated protein A; K06096	VAMP associated protein A [Source:HGNC Symbol%3BAcc:HGNC:12648]
ENSG00000101384	35.65	33.21	38.25	39.35	37.49	40.76	-0.121574241682081	7.16429585938702	0.0778195593839403	0.375024295284543	20:10637683-10674107:-	JAG1	58;GO:0001525,biological_process angiogenesis;GO:0001709,biological_process cell fate determination;GO:0001974,biological_process blood vessel remodeling;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0002456,biological_process T cell mediated immunity;GO:0003184,biological_process pulmonary valve morphogenesis;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0005112,molecular_function Notch binding;GO:0005198,molecular_function structural molecule activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005912,cellular_component adherens junction;GO:0007154,biological_process cell communication;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008083,molecular_function growth factor activity;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030097,biological_process hemopoiesis;GO:0030216,biological_process keratinocyte differentiation;GO:0030334,biological_process regulation of cell migration;GO:0032495,biological_process response to muramyl dipeptide;GO:0035909,biological_process aorta morphogenesis;GO:0042127,biological_process regulation of cell proliferation;GO:0042491,biological_process auditory receptor cell differentiation;GO:0043010,biological_process camera-type eye development;GO:0045177,cellular_component apical part of cell;GO:0045445,biological_process myoblast differentiation;GO:0045446,biological_process endothelial cell differentiation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045602,biological_process negative regulation of endothelial cell differentiation;GO:0045639,biological_process positive regulation of myeloid cell differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048839,biological_process inner ear development;GO:0060411,biological_process cardiac septum morphogenesis;GO:0061073,biological_process ciliary body morphogenesis;GO:0061156,biological_process pulmonary artery morphogenesis;GO:0061309,biological_process cardiac neural crest cell development involved in outflow tract morphogenesis;GO:0061314,biological_process Notch signaling involved in heart development;GO:0061444,biological_process endocardial cushion cell development;GO:0072006,biological_process nephron development;GO:0072015,biological_process glomerular visceral epithelial cell development;GO:0072017,biological_process distal tubule development;GO:0072070,biological_process loop of Henle development;GO:0097150,biological_process neuronal stem cell population maintenance;GO:2000737,biological_process negative regulation of stem cell differentiation	JAG1, CD339; jagged-1; K06052	jagged 1 [Source:HGNC Symbol%3BAcc:HGNC:6188]
ENSG00000131148	32.29	37.47	34.23	39.81	38.04	38.62	-0.158987112421818	4.54160438210979	0.0778637305886773	0.375024295284543	16:85771757-85799608:-	EMC8	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:7864]
ENSG00000106603	128.92	127.05	127.56	139.01	140.06	137.86	-0.108363490358072	6.34350283384078	0.0778673876750591	0.375024295284543	7:43608455-43729717:-	COA1	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	cytochrome c oxidase assembly factor 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:21868]
ENSG00000007516	1.17	1.03	1.58	0.84	0.98	1.14	0.366708932028113	2.08869034343111	0.077881742554879	0.375024295284543	16:1333600-1349441:+	BAIAP3	5;GO:0005783,cellular_component endoplasmic reticulum;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007269,biological_process neurotransmitter secretion;GO:0008022,molecular_function protein C-terminus binding;GO:0098793,cellular_component presynapse	BAIAP3; BAI1-associated protein 3; K15621	BAI1 associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:948]
ENSG00000181019	318.34	372.30	314.31	306.41	322.83	293.44	0.134268638353087	8.35318157286319	0.0778871049096554	0.375024295284543	16:69706995-69726951:-	NQO1	28;GO:0003723,molecular_function RNA binding;GO:0003955,molecular_function NAD(P)H dehydrogenase (quinone) activity;GO:0004128,molecular_function cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0004784,molecular_function superoxide dismutase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006801,biological_process superoxide metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0006979,biological_process response to oxidative stress;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0009636,biological_process response to toxic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0016491,molecular_function oxidoreductase activity;GO:0019430,biological_process removal of superoxide radicals;GO:0032355,biological_process response to estradiol;GO:0042802,molecular_function identical protein binding;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045471,biological_process response to ethanol;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]; K00355	NAD(P)H quinone dehydrogenase 1 [Source:HGNC Symbol%3BAcc:HGNC:2874]
ENSG00000159079	3.52	2.76	2.70	2.49	2.52	1.91	0.401868503769065	1.66903602422074	0.0781888007796366	0.376330974826533	21:32592078-32612866:-	C21orf59	4;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0048858,biological_process cell projection morphogenesis	NA	chromosome 21 open reading frame 59 [Source:HGNC Symbol%3BAcc:HGNC:1301]
ENSG00000185252	4.13	4.53	4.16	3.29	3.70	3.98	0.227916883609424	3.05846046303956	0.078221642352105	0.376343118804914	22:20394114-20408461:+	ZNF74	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0015629,cellular_component actin cytoskeleton;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 74 [Source:HGNC Symbol%3BAcc:HGNC:13144]
ENSG00000165338	5.44	6.48	6.05	5.33	5.40	5.06	0.19111005278712	3.74225502808338	0.0784222079249124	0.377029858406785	10:91409279-91514829:+	HECTD2	7;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	HECT domain E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:26736]
ENSG00000162614	10.27	10.89	10.05	10.26	7.90	9.50	0.182047959041746	4.32884158853044	0.0784251264324755	0.377029858406785	1:77888512-77943895:+	NEXN	12;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005912,cellular_component adherens junction;GO:0005925,cellular_component focal adhesion;GO:0008307,molecular_function structural constituent of muscle;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030334,biological_process regulation of cell migration;GO:0048739,biological_process cardiac muscle fiber development;GO:0051015,molecular_function actin filament binding;GO:0051493,biological_process regulation of cytoskeleton organization	NA	nexilin F-actin binding protein [Source:HGNC Symbol%3BAcc:HGNC:29557]
ENSG00000164366	39.03	41.29	40.95	47.42	41.71	45.35	-0.139704974575463	5.06299240705634	0.0784716593349208	0.377107513482142	5:196870-218215:-	CCDC127	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	coiled-coil domain containing 127 [Source:HGNC Symbol%3BAcc:HGNC:30520]
ENSG00000204899	45.65	48.56	42.19	49.91	53.95	53.45	-0.200639048585612	3.6086314531084	0.078682331072861	0.377973597371294	13:72708356-72727687:-	MZT1	14;GO:0000923,cellular_component equatorial microtubule organizing center;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008274,cellular_component gamma-tubulin ring complex;GO:0031021,cellular_component interphase microtubule organizing center;GO:0033566,biological_process gamma-tubulin complex localization;GO:0043015,molecular_function gamma-tubulin binding;GO:0051415,biological_process interphase microtubule nucleation by interphase microtubule organizing center;GO:0090307,biological_process mitotic spindle assembly	NA	mitotic spindle organizing protein 1 [Source:HGNC Symbol%3BAcc:HGNC:33830]
ENSG00000189319	4.04	4.80	5.25	3.29	4.52	3.64	0.309210459709871	2.47367135883037	0.0787824333237431	0.378268839934312	10:124619291-124744269:-	FAM53B	4;GO:0005634,cellular_component nucleus;GO:0016055,biological_process Wnt signaling pathway;GO:0035411,biological_process catenin import into nucleus;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	family with sequence similarity 53 member B [Source:HGNC Symbol%3BAcc:HGNC:28968]
ENSG00000134247	41.38	44.36	40.86	44.86	49.01	44.77	-0.120583770383203	6.86745163362914	0.0788047385861702	0.378268839934312	1:116910056-116990358:+	PTGFRN	9;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034389,biological_process lipid particle organization	NA	prostaglandin F2 receptor inhibitor [Source:HGNC Symbol%3BAcc:HGNC:9601]
ENSG00000139173	1.88	2.29	1.91	1.46	1.52	1.64	0.389290409638138	1.5251065311915	0.078902148374392	0.37858567192645	12:43835966-44389762:+	TMEM117	5;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 117 [Source:HGNC Symbol%3BAcc:HGNC:25308]
ENSG00000143493	13.52	12.33	14.21	15.67	13.49	15.53	-0.142762360995587	5.39096078007326	0.078931742443056	0.37858567192645	1:211940398-212035542:-	INTS7	14;GO:0000077,biological_process DNA damage checkpoint;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016180,biological_process snRNA processing;GO:0016607,cellular_component nuclear speck;GO:0032039,cellular_component integrator complex;GO:0034472,biological_process snRNA 3'-end processing;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0071479,biological_process cellular response to ionizing radiation	NA	integrator complex subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:24484]
ENSG00000163577	24.47	22.07	26.78	22.18	18.34	22.67	0.230989895875986	3.40882906227315	0.0789642521130729	0.378595311502346	3:170888414-170908693:-	EIF5A2	24;GO:0003723,molecular_function RNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0006452,biological_process translational frameshifting;GO:0006810,biological_process transport;GO:0007283,biological_process spermatogenesis;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008612,biological_process peptidyl-lysine modification to peptidyl-hypusine;GO:0010509,biological_process polyamine homeostasis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0043022,molecular_function ribosome binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045901,biological_process positive regulation of translational elongation;GO:0045905,biological_process positive regulation of translational termination;GO:0051028,biological_process mRNA transport	NA	eukaryotic translation initiation factor 5A2 [Source:HGNC Symbol%3BAcc:HGNC:3301]
ENSG00000184916	1.88	1.72	1.80	1.57	1.20	1.70	0.283417091135539	2.65115903404492	0.0790053529402359	0.378646118164922	14:105140980-105168824:-	JAG2	29;GO:0001501,biological_process skeletal system development;GO:0001701,biological_process in utero embryonic development;GO:0003016,biological_process respiratory system process;GO:0005112,molecular_function Notch binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007049,biological_process cell cycle;GO:0007154,biological_process cell communication;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008083,molecular_function growth factor activity;GO:0009912,biological_process auditory receptor cell fate commitment;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0030154,biological_process cell differentiation;GO:0030155,biological_process regulation of cell adhesion;GO:0030217,biological_process T cell differentiation;GO:0030334,biological_process regulation of cell migration;GO:0042127,biological_process regulation of cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042492,biological_process gamma-delta T cell differentiation;GO:0045061,biological_process thymic T cell selection;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:1990134,biological_process epithelial cell apoptotic process involved in palatal shelf morphogenesis	JAG1, CD339; jagged-1; K06052	jagged 2 [Source:HGNC Symbol%3BAcc:HGNC:6189]
ENSG00000145194	0.88	1.02	1.28	0.78	0.95	0.71	0.402721872293698	1.68120567644704	0.0792333417978452	0.379592231469183	3:184249649-184293031:+	ECE2	23;GO:0000139,cellular_component Golgi membrane;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006508,biological_process proteolysis;GO:0007267,biological_process cell-cell signaling;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0010002,biological_process cardioblast differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016486,biological_process peptide hormone processing;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0030658,cellular_component transport vesicle membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	endothelin converting enzyme 2 [Source:HGNC Symbol%3BAcc:HGNC:13275]
ENSG00000181938	6.46	8.99	5.68	9.00	8.53	8.64	-0.319221259802384	2.62080352207082	0.079344431486655	0.379977788597164	16:58295079-58406144:+	GINS3	4;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006271,biological_process DNA strand elongation involved in DNA replication	NA	GINS complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:25851]
ENSG00000091127	17.06	20.34	18.82	16.76	16.22	18.08	0.144182254571991	5.15174847372925	0.0794138714523395	0.380015100709585	7:105439660-105522267:-	PUS7	8;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity;GO:0019899,molecular_function enzyme binding	NA	pseudouridylate synthase 7 (putative) [Source:HGNC Symbol%3BAcc:HGNC:26033]
ENSG00000162775	13.95	14.26	13.37	12.88	12.51	13.08	0.12135933678867	5.31955553543789	0.0794554577878366	0.380015100709585	1:110338505-110346681:+	RBM15	16;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001569,biological_process patterning of blood vessels;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007221,biological_process positive regulation of transcription of Notch receptor target;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016607,cellular_component nuclear speck;GO:0031965,cellular_component nuclear membrane;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0048536,biological_process spleen development;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060674,biological_process placenta blood vessel development	NA	RNA binding motif protein 15 [Source:HGNC Symbol%3BAcc:HGNC:14959]
ENSG00000178188	23.39	26.23	27.46	22.36	24.81	23.66	0.132567246255458	5.94002608211502	0.0794563674633789	0.380015100709585	16:28846599-28874212:+	SH2B1	15;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0009967,biological_process positive regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0030032,biological_process lamellipodium assembly;GO:0035556,biological_process intracellular signal transduction;GO:0035591,molecular_function signaling adaptor activity;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:2000278,biological_process regulation of DNA biosynthetic process	SH2B1_3; SH2B adaptor protein 1/3; K12459	SH2B adaptor protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30417]
ENSG00000163535	13.73	15.81	13.13	14.45	17.41	15.87	-0.15384066790704	5.85493409769152	0.0794746798873828	0.380015100709585	2:200510007-200583782:+	SGO2	16;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0016604,cellular_component nuclear body;GO:0030892,cellular_component mitotic cohesin complex;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051754,biological_process meiotic sister chromatid cohesion, centromeric	NA	shugoshin 2 [Source:HGNC Symbol%3BAcc:HGNC:30812]
ENSG00000117448	112.21	118.09	110.22	108.97	107.49	99.94	0.1167892299283	6.77237848264162	0.0795248612652502	0.380108626448036	1:45550542-45570049:+	AKR1A1	19;GO:0004032,molecular_function alditol:NADP+ 1-oxidoreductase activity;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0006006,biological_process glucose metabolic process;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0008106,molecular_function alcohol dehydrogenase (NADP+) activity;GO:0009055,molecular_function electron carrier activity;GO:0016324,cellular_component apical plasma membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019640,biological_process glucuronate catabolic process to xylulose 5-phosphate;GO:0019853,biological_process L-ascorbic acid biosynthetic process;GO:0042840,biological_process D-glucuronate catabolic process;GO:0046185,biological_process aldehyde catabolic process;GO:0047939,molecular_function L-glucuronate reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:1901687,biological_process glutathione derivative biosynthetic process	AKR1A1, adh; alcohol dehydrogenase (NADP+) [EC:1.1.1.2]; K00002	aldo-keto reductase family 1 member A1 [Source:HGNC Symbol%3BAcc:HGNC:380]
ENSG00000072415	21.78	19.44	20.67	22.90	24.55	21.27	-0.135115595516092	5.47316045170673	0.0796168242899748	0.380401708972847	14:67241108-67335819:+	MPP5	21;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007009,biological_process plasma membrane organization;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0032287,biological_process peripheral nervous system myelin maintenance;GO:0032288,biological_process myelin assembly;GO:0035749,cellular_component myelin sheath adaxonal region;GO:0035750,biological_process protein localization to myelin sheath abaxonal region;GO:0043219,cellular_component lateral loop;GO:0043220,cellular_component Schmidt-Lanterman incisure;GO:0043234,cellular_component protein complex;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0090162,biological_process establishment of epithelial cell polarity	MPP5, PALS1; MAGUK p55 subfamily member 5; K06091	membrane palmitoylated protein 5 [Source:HGNC Symbol%3BAcc:HGNC:18669]
ENSG00000196581	1.60	1.86	2.92	2.98	3.08	2.57	-0.409481004088167	1.70218419839479	0.0796979064752491	0.380580813953897	1:4654731-4792534:+	AJAP1	18;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0007155,biological_process cell adhesion;GO:0008013,molecular_function beta-catenin binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction;GO:0030860,biological_process regulation of polarized epithelial cell differentiation;GO:0032403,molecular_function protein complex binding;GO:0044214,cellular_component spanning component of plasma membrane;GO:0044291,cellular_component cell-cell contact zone;GO:0061045,biological_process negative regulation of wound healing	NA	adherens junctions associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30801]
ENSG00000123453	8.55	8.57	7.45	7.42	7.85	6.88	0.160238977050373	4.64067671221761	0.0797265538009456	0.380580813953897	9:133663559-133739955:-	SARDH	8;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008150,biological_process biological_process;GO:0008480,molecular_function sarcosine dehydrogenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0042426,biological_process choline catabolic process;GO:0055114,biological_process oxidation-reduction process;GO:1901053,biological_process sarcosine catabolic process	SARDH; sarcosine dehydrogenase [EC:1.5.8.3]; K00314	sarcosine dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:10536]
ENSG00000160214	31.97	28.36	30.72	28.16	26.07	29.50	0.135784228439421	5.34193949788378	0.0797711246310575	0.380580813953897	21:43789512-43805293:+	RRP1	6;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0030688,cellular_component preribosome, small subunit precursor	NA	ribosomal RNA processing 1 [Source:HGNC Symbol%3BAcc:HGNC:18785]
ENSG00000064652	12.81	14.01	16.77	18.15	18.16	15.51	-0.234754419497583	3.47648026074434	0.0797769498032739	0.380580813953897	5:122843438-123029354:+	SNX24	10;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	sorting nexin 24 [Source:HGNC Symbol%3BAcc:HGNC:21533]
ENSG00000101665	8.73	7.85	9.10	7.67	5.88	8.31	0.246862950184364	3.3650591645472	0.0798367140046725	0.380620982699034	18:48919852-48950711:-	SMAD7	64;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001650,cellular_component fibrillar center;GO:0001657,biological_process ureteric bud development;GO:0002725,biological_process negative regulation of T cell cytokine production;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008013,molecular_function beta-catenin binding;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0010944,biological_process negative regulation of transcription by competitive promoter binding;GO:0016342,cellular_component catenin complex;GO:0016579,biological_process protein deubiquitination;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030336,biological_process negative regulation of cell migration;GO:0030509,biological_process BMP signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030617,molecular_function transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032925,biological_process regulation of activin receptor signaling pathway;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034333,biological_process adherens junction assembly;GO:0034616,biological_process response to laminar fluid shear stress;GO:0034629,biological_process cellular protein complex localization;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0043234,cellular_component protein complex;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048185,molecular_function activin binding;GO:0048844,biological_process artery morphogenesis;GO:0050821,biological_process protein stabilization;GO:0051444,biological_process negative regulation of ubiquitin-protein transferase activity;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0060373,biological_process regulation of ventricular cardiac muscle cell membrane depolarization;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060394,biological_process negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0070411,molecular_function I-SMAD binding;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000317,biological_process negative regulation of T-helper 17 type immune response;GO:2000320,biological_process negative regulation of T-helper 17 cell differentiation	SMAD6; mothers against decapentaplegic homolog 6; K04677	SMAD family member 7 [Source:HGNC Symbol%3BAcc:HGNC:6773]
ENSG00000159579	25.44	23.67	27.44	29.03	28.28	27.22	-0.127169833529356	5.61876759994727	0.079846696120864	0.380620982699034	16:57186136-57240475:+	RSPRY1	2;GO:0005576,cellular_component extracellular region;GO:0046872,molecular_function metal ion binding	NA	ring finger and SPRY domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29420]
ENSG00000154358	1.15	1.02	1.28	1.11	0.97	1.04	0.163833510447792	4.95860070396328	0.0798884005934859	0.380650363051324	1:228208129-228378874:+	OBSCN	35;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0008307,molecular_function structural constituent of muscle;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0030016,cellular_component myofibril;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030154,biological_process cell differentiation;GO:0030506,molecular_function ankyrin binding;GO:0031430,cellular_component M band;GO:0031432,molecular_function titin binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0036309,biological_process protein localization to M-band;GO:0042383,cellular_component sarcolemma;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045214,biological_process sarcomere organization;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	obscurin%2C cytoskeletal calmodulin and titin-interacting RhoGEF [Source:HGNC Symbol%3BAcc:HGNC:15719]
ENSG00000120539	13.39	14.06	13.59	14.17	14.50	17.07	-0.147118511701384	5.260528862527	0.0799365563314122	0.380650363051324	10:27154823-27186924:+	MASTL	27;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007147,biological_process female meiosis II;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032154,cellular_component cleavage furrow;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0035556,biological_process intracellular signal transduction;GO:0051301,biological_process cell division;GO:0051441,biological_process positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0051726,biological_process regulation of cell cycle	NA	microtubule associated serine/threonine kinase like [Source:HGNC Symbol%3BAcc:HGNC:19042]
ENSG00000137857	0.49	0.51	0.48	0.74	0.56	0.65	-0.394756815649074	1.52327132671038	0.0799448559151536	0.380650363051324	15:45129932-45165576:+	DUOX1	23;GO:0004601,molecular_function peroxidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0006590,biological_process thyroid hormone generation;GO:0006979,biological_process response to oxidative stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016174,molecular_function NAD(P)H oxidase activity;GO:0016324,cellular_component apical plasma membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0020037,molecular_function heme binding;GO:0042335,biological_process cuticle development;GO:0042446,biological_process hormone biosynthetic process;GO:0042554,biological_process superoxide anion generation;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050661,molecular_function NADP binding;GO:0050665,biological_process hydrogen peroxide biosynthetic process;GO:0051591,biological_process response to cAMP;GO:0055114,biological_process oxidation-reduction process;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0098869,biological_process cellular oxidant detoxification	DUOX, THOX; dual oxidase [EC:1.6.3.1 1.11.1.-]; K13411	dual oxidase 1 [Source:HGNC Symbol%3BAcc:HGNC:3062]
ENSG00000115966	42.58	37.26	40.93	44.50	45.48	42.72	-0.120185107213977	6.00693169103864	0.0800010418544068	0.380771829961178	2:175072249-175168382:-	ATF2	52;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003151,biological_process outflow tract morphogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006970,biological_process response to osmotic stress;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008134,molecular_function transcription factor binding;GO:0008140,molecular_function cAMP response element binding protein binding;GO:0009414,biological_process response to water deprivation;GO:0016020,cellular_component membrane;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0032915,biological_process positive regulation of transforming growth factor beta2 production;GO:0035497,molecular_function cAMP response element binding;GO:0035861,cellular_component site of double-strand break;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045444,biological_process fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060612,biological_process adipose tissue development;GO:0097186,biological_process amelogenesis;GO:0110024,Biological_Process positive regulation of cardiac muscle myoblast proliferation;GO:1902110,biological_process positive regulation of mitochondrial membrane permeability involved in apoptotic process	ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2; K04450	activating transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:784]
ENSG00000213533	1.67	1.28	1.81	1.15	0.93	1.16	0.57811810012808	0.542476775930604	0.0801188608887073	0.381186439329829	3:52836218-52897596:-	TMEM110	13;GO:0003674,molecular_function molecular_function;GO:0005246,molecular_function calcium channel regulator activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032237,biological_process activation of store-operated calcium channel activity;GO:0032541,cellular_component cortical endoplasmic reticulum;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0051533,biological_process positive regulation of NFAT protein import into nucleus	NA	transmembrane protein 110 [Source:HGNC Symbol%3BAcc:HGNC:30526]
ENSG00000069424	3.61	3.80	4.20	3.11	3.84	2.79	0.267204183456598	2.98663419906045	0.0803133682860502	0.381965456143579	1:5991465-6101193:+	KCNAB2	38;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0014069,cellular_component postsynaptic density;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035579,cellular_component specific granule membrane;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043312,biological_process neutrophil degranulation;GO:0043679,cellular_component axon terminus;GO:0044224,cellular_component juxtaparanode region of axon;GO:0045202,cellular_component synapse;GO:0050905,biological_process neuromuscular process;GO:0055114,biological_process oxidation-reduction process;GO:0065009,biological_process regulation of molecular function;GO:0070821,cellular_component tertiary granule membrane;GO:0070995,biological_process NADPH oxidation;GO:0071805,biological_process potassium ion transmembrane transport;GO:1901379,biological_process regulation of potassium ion transmembrane transport;GO:1990031,cellular_component pinceau fiber;GO:2000008,biological_process regulation of protein localization to cell surface	NA	potassium voltage-gated channel subfamily A regulatory beta subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:6229]
ENSG00000161638	59.29	54.08	60.48	57.91	46.80	54.32	0.140975308044981	7.45063923950308	0.0803531139008284	0.382008120586359	12:54395260-54419460:-	ITGA5	49;GO:0001525,biological_process angiogenesis;GO:0001618,molecular_function virus receptor activity;GO:0001726,cellular_component ruffle;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0007044,biological_process cell-substrate junction assembly;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007613,biological_process memory;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031589,biological_process cell-substrate adhesion;GO:0032587,cellular_component ruffle membrane;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0033631,biological_process cell-cell adhesion mediated by integrin;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0035313,biological_process wound healing, spreading of epidermal cells;GO:0035987,biological_process endodermal cell differentiation;GO:0043184,molecular_function vascular endothelial growth factor receptor 2 binding;GO:0045202,cellular_component synapse;GO:0045765,biological_process regulation of angiogenesis;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0071062,cellular_component alphav-beta3 integrin-vitronectin complex;GO:1903672,biological_process positive regulation of sprouting angiogenesis;GO:2000811,biological_process negative regulation of anoikis	ITGA5, CD49e; integrin alpha 5; K06484	integrin subunit alpha 5 [Source:HGNC Symbol%3BAcc:HGNC:6141]
ENSG00000173653	18.53	18.98	17.15	16.61	15.14	17.17	0.16712845594241	4.10182279888651	0.0806043216702913	0.38305568334354	11:66842834-66846546:+	RCE1	15;GO:0004175,molecular_function endopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0071586,biological_process CAAX-box protein processing	RCE1, FACE2; prenyl protein peptidase [EC:3.4.22.-]; K08658	Ras converting CAAX endopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:13721]
ENSG00000145332	7.40	7.81	7.64	8.65	8.32	8.92	-0.172423277665137	3.93380176374351	0.0806906961650534	0.383319407384924	4:87160102-87240314:-	KLHL8	5;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005654,cellular_component nucleoplasm;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	kelch like family member 8 [Source:HGNC Symbol%3BAcc:HGNC:18644]
ENSG00000160447	5.19	5.55	4.94	5.53	6.26	6.09	-0.182789034089009	3.9140464601868	0.0808165347699898	0.383648688156303	9:128702522-128720918:+	PKN3	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0010631,biological_process epithelial cell migration;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0048471,cellular_component perinuclear region of cytoplasm	PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]; K06071	protein kinase N3 [Source:HGNC Symbol%3BAcc:HGNC:17999]
ENSG00000198707	7.83	7.43	8.28	8.73	8.57	8.45	-0.114481570100373	5.96194315943069	0.0808218254675527	0.383648688156303	12:88049013-88142216:-	CEP290	37;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000930,cellular_component gamma-tubulin complex;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0030902,biological_process hindbrain development;GO:0030916,biological_process otic vesicle formation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0034451,cellular_component centriolar satellite;GO:0035580,cellular_component specific granule lumen;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0036064,cellular_component ciliary basal body;GO:0042462,biological_process eye photoreceptor cell development;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048793,biological_process pronephros development;GO:0060271,biological_process cilium morphogenesis;GO:0070201,biological_process regulation of establishment of protein localization;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 290 [Source:HGNC Symbol%3BAcc:HGNC:29021]
ENSG00000126432	476.01	454.61	470.96	434.54	438.28	445.24	0.100758898237544	8.18673558739087	0.0808620009325488	0.383692667269009	11:64318087-64321811:+	PRDX5	31;GO:0001016,molecular_function RNA polymerase III regulatory region DNA binding;GO:0004601,molecular_function peroxidase activity;GO:0005102,molecular_function receptor binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006979,biological_process response to oxidative stress;GO:0008379,molecular_function thioredoxin peroxidase activity;GO:0016209,molecular_function antioxidant activity;GO:0016480,biological_process negative regulation of transcription from RNA polymerase III promoter;GO:0016491,molecular_function oxidoreductase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034599,biological_process cellular response to oxidative stress;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045454,biological_process cell redox homeostasis;GO:0046983,molecular_function protein dimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051920,molecular_function peroxiredoxin activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	PRDX5; peroxiredoxin 5, atypical 2-Cys peroxiredoxin [EC:1.11.1.15]; K11187	peroxiredoxin 5 [Source:HGNC Symbol%3BAcc:HGNC:9355]
ENSG00000137338	4.34	4.69	4.03	4.63	5.81	4.87	-0.222498440940732	3.53857436698161	0.0808968920806361	0.383711548107351	6:28281571-28302549:+	PGBD1	7;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006898,biological_process receptor-mediated endocytosis;GO:0016020,cellular_component membrane;GO:0042802,molecular_function identical protein binding	NA	piggyBac transposable element derived 1 [Source:HGNC Symbol%3BAcc:HGNC:19398]
ENSG00000087269	18.56	17.42	18.27	20.12	19.39	19.79	-0.114384706462697	5.67257105166296	0.0809729648047867	0.38392567307938	4:2937932-2963385:-	NOP14	19;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472,biological_process endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480,biological_process endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0019899,molecular_function enzyme binding;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030515,molecular_function snoRNA binding;GO:0030686,cellular_component 90S preribosome;GO:0030692,cellular_component Noc4p-Nop14p complex;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis	NA	NOP14 nucleolar protein [Source:HGNC Symbol%3BAcc:HGNC:16821]
ENSG00000162298	19.23	19.21	19.32	16.62	18.11	18.50	0.128883499202035	5.10435180368709	0.0810616652984732	0.384199485051527	11:65121779-65134533:-	SYVN1	32;GO:0000836,cellular_component Hrd1p ubiquitin ligase complex;GO:0000839,cellular_component Hrd1p ubiquitin ligase ERAD-L complex;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051117,molecular_function ATPase binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904380,biological_process endoplasmic reticulum mannose trimming;GO:1990381,molecular_function ubiquitin-specific protease binding	SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]; K10601	synoviolin 1 [Source:HGNC Symbol%3BAcc:HGNC:20738]
ENSG00000253309	1.40	1.24	2.19	1.43	1.16	0.80	0.542439798779398	0.964115352952873	0.0811356600465381	0.384403415327358	13:51335772-51364735:+	SERPINE3	6;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity	NA	serpin family E member 3 [Source:HGNC Symbol%3BAcc:HGNC:24774]
ENSG00000164294	48.10	58.22	48.01	44.06	52.01	40.26	0.186316332231892	4.9265126604579	0.0811735329676426	0.384436117789907	5:55160117-55167071:+	GPX8	10;GO:0004601,molecular_function peroxidase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006979,biological_process response to oxidative stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0055114,biological_process oxidation-reduction process;GO:0098869,biological_process cellular oxidant detoxification	gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9]; K00432	glutathione peroxidase 8 (putative) [Source:HGNC Symbol%3BAcc:HGNC:33100]
ENSG00000250510	0.52	0.61	1.36	0.47	0.60	0.52	0.664333049907627	0.53012607324717	0.0812120336505154	0.384471767240216	12:6821544-6829972:+	GPR162	7;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 162 [Source:HGNC Symbol%3BAcc:HGNC:16693]
ENSG00000168246	39.54	40.02	36.28	43.41	41.70	43.27	-0.139485617686022	4.8453202570351	0.0813366840123999	0.38491508145098	5:172209639-172284071:-	UBTD2	2;GO:0005737,cellular_component cytoplasm;GO:0043130,molecular_function ubiquitin binding	NA	ubiquitin domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24463]
ENSG00000184007	391.25	342.99	399.09	443.56	385.96	422.71	-0.131178083714636	7.7164132731373	0.0814600654707846	0.384918102647484	1:31906420-31944856:-	PTP4A2	17;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004727,molecular_function prenylated protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043687,biological_process post-translational protein modification;GO:0070062,cellular_component extracellular exosome	NA	protein tyrosine phosphatase type IVA%2C member 2 [Source:HGNC Symbol%3BAcc:HGNC:9635]
ENSG00000155906	23.54	21.78	24.92	26.68	25.22	26.00	-0.132974166558139	5.06577159874817	0.0814974562188219	0.384918102647484	6:151404762-151452181:-	RMND1	4;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0070131,biological_process positive regulation of mitochondrial translation	NA	required for meiotic nuclear division 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:21176]
ENSG00000130935	27.68	28.91	27.70	29.96	31.14	30.61	-0.111699190931961	6.08262079127068	0.0815034062224593	0.384918102647484	17:67717832-67744531:+	NOL11	12;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0030490,biological_process maturation of SSU-rRNA;GO:0034455,cellular_component t-UTP complex;GO:0042254,biological_process ribosome biogenesis;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter	NA	nucleolar protein 11 [Source:HGNC Symbol%3BAcc:HGNC:24557]
ENSG00000177469	131.77	140.90	135.06	118.00	131.59	129.70	0.115321125133838	7.26368042443162	0.0815085628514655	0.384918102647484	17:42402451-42423517:-	CAVIN1	23;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006351,biological_process transcription, DNA-templated;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0009303,biological_process rRNA transcription;GO:0016020,cellular_component membrane;GO:0019843,molecular_function rRNA binding;GO:0042134,molecular_function rRNA primary transcript binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045121,cellular_component membrane raft;GO:2000147,biological_process positive regulation of cell motility	NA	caveolae associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9688]
ENSG00000163728	26.38	21.14	24.07	19.98	23.15	22.14	0.14917673247363	5.90093417775529	0.0815290199987472	0.384918102647484	3:180602129-180617828:+	TTC14	1;GO:0003676,molecular_function nucleic acid binding	NA	tetratricopeptide repeat domain 14 [Source:HGNC Symbol%3BAcc:HGNC:24697]
ENSG00000205129	3.28	2.68	4.05	2.34	2.70	2.65	0.405764316648153	1.53594735830542	0.0815478121529258	0.384918102647484	4:185426248-185449826:+	C4orf47	4;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton	NA	chromosome 4 open reading frame 47 [Source:HGNC Symbol%3BAcc:HGNC:34346]
ENSG00000140829	22.24	23.32	21.53	23.66	24.31	25.16	-0.114344075704665	6.45796972389808	0.0815543873328674	0.384918102647484	16:72093561-72112912:+	DHX38	21;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031124,biological_process mRNA 3'-end processing;GO:0071013,cellular_component catalytic step 2 spliceosome	DHX38, PRP16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 [EC:3.6.4.13]; K12815	DEAH-box helicase 38 [Source:HGNC Symbol%3BAcc:HGNC:17211]
ENSG00000115993	27.82	28.72	27.19	24.98	27.80	24.88	0.119414245329144	6.22472322110431	0.0816156993307705	0.385061070236736	2:201377206-201451579:-	TRAK2	17;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006493,biological_process protein O-linked glycosylation;GO:0006605,biological_process protein targeting;GO:0006810,biological_process transport;GO:0019894,molecular_function kinesin binding;GO:0019899,molecular_function enzyme binding;GO:0032839,cellular_component dendrite cytoplasm;GO:0050811,molecular_function GABA receptor binding;GO:0098972,biological_process anterograde dendritic transport of mitochondrion	TRAK2, GRIF1; trafficking kinesin-binding protein 2; K15374	trafficking kinesin protein 2 [Source:HGNC Symbol%3BAcc:HGNC:13206]
ENSG00000132004	11.58	10.51	10.96	11.86	12.80	12.78	-0.163792727838953	4.12120828343417	0.0817101770796515	0.385164511261231	19:12688052-12696643:-	FBXW9	5;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	F-box and WD repeat domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:28136]
ENSG00000238227	19.48	15.81	17.30	13.29	18.19	11.30	0.319965779570462	2.76113980593479	0.0817560566849029	0.385164511261231	9:136114580-136118863:-	TMEM250	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0048524,biological_process positive regulation of viral process	NA	transmembrane protein 250 [Source:HGNC Symbol%3BAcc:HGNC:31009]
ENSG00000130741	171.46	157.07	155.52	176.73	168.87	181.73	-0.111448766116125	7.97152319528938	0.0817741681584055	0.385164511261231	X:24054715-24077971:+	EIF2S3	14;GO:0000166,molecular_function nucleotide binding;GO:0003743,molecular_function translation initiation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005850,cellular_component eukaryotic translation initiation factor 2 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0045296,molecular_function cadherin binding;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	EIF2S3; translation initiation factor 2 subunit 3; K03242	eukaryotic translation initiation factor 2 subunit gamma [Source:HGNC Symbol%3BAcc:HGNC:3267]
ENSG00000166189	8.38	9.12	7.47	6.47	8.42	6.96	0.200885342437164	4.18824537559122	0.0818193438845637	0.385164511261231	10:102065389-102068038:+	HPS6	20;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006996,biological_process organelle organization;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030318,biological_process melanocyte differentiation;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031084,cellular_component BLOC-2 complex;GO:0031090,cellular_component organelle membrane;GO:0031901,cellular_component early endosome membrane;GO:0032418,biological_process lysosome localization;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043473,biological_process pigmentation;GO:0072657,biological_process protein localization to membrane	NA	HPS6%2C biogenesis of lysosomal organelles complex 2 subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:18817]
ENSG00000134775	18.07	16.91	18.66	19.61	19.09	19.88	-0.113774532211139	6.51259995734104	0.081850613867917	0.385164511261231	18:36297713-36780055:+	FHOD3	12;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005865,cellular_component striated muscle thin filament;GO:0007015,biological_process actin filament organization;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0045214,biological_process sarcomere organization;GO:0051639,biological_process actin filament network formation;GO:0055003,biological_process cardiac myofibril assembly	NA	formin homology 2 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:26178]
ENSG00000173281	14.95	14.53	15.75	12.87	13.57	13.65	0.188243325512162	3.62236611777977	0.0818579299392087	0.385164511261231	8:9136254-9151574:-	PPP1R3B	12;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005979,biological_process regulation of glycogen biosynthetic process;GO:0005981,biological_process regulation of glycogen catabolic process;GO:0006470,biological_process protein dephosphorylation;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0019899,molecular_function enzyme binding;GO:0042587,cellular_component glycogen granule;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050790,biological_process regulation of catalytic activity	PPP1R3; protein phosphatase 1 regulatory subunit 3A/B/C/D/E; K07189	protein phosphatase 1 regulatory subunit 3B [Source:HGNC Symbol%3BAcc:HGNC:14942]
ENSG00000164219	12.74	12.76	13.47	15.03	14.22	14.86	-0.165897700935942	3.98595936834663	0.0818816436942765	0.385164511261231	5:115204011-115262872:-	PGGT1B	16;GO:0003824,molecular_function catalytic activity;GO:0004659,molecular_function prenyltransferase activity;GO:0004661,molecular_function protein geranylgeranyltransferase activity;GO:0004662,molecular_function CAAX-protein geranylgeranyltransferase activity;GO:0005953,cellular_component CAAX-protein geranylgeranyltransferase complex;GO:0008144,molecular_function drug binding;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016740,molecular_function transferase activity;GO:0018344,biological_process protein geranylgeranylation;GO:0019840,molecular_function isoprenoid binding;GO:0034097,biological_process response to cytokine;GO:0042277,molecular_function peptide binding;GO:0045787,biological_process positive regulation of cell cycle;GO:0046872,molecular_function metal ion binding;GO:0051771,biological_process negative regulation of nitric-oxide synthase biosynthetic process	NA	protein geranylgeranyltransferase type I subunit beta [Source:HGNC Symbol%3BAcc:HGNC:8895]
ENSG00000111665	35.27	40.33	34.03	40.66	46.40	36.96	-0.169855301286452	5.16297335699931	0.0819526592652867	0.385164511261231	12:6844792-6852066:-	CDCA3	10;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005913,cellular_component cell-cell adherens junction;GO:0007049,biological_process cell cycle;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0051301,biological_process cell division	NA	cell division cycle associated 3 [Source:HGNC Symbol%3BAcc:HGNC:14624]
ENSG00000197157	103.39	115.67	96.71	93.34	102.26	95.22	0.1297697811917	8.11134625332242	0.0819791748561346	0.385164511261231	7:127652179-128092609:+	SND1	22;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006401,biological_process RNA catabolic process;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016442,cellular_component RISC complex;GO:0031047,biological_process gene silencing by RNA;GO:0042470,cellular_component melanosome;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0097433,cellular_component dense body	SND1; staphylococcal nuclease domain-containing protein 1; K15979	staphylococcal nuclease and tudor domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30646]
ENSG00000164627	0.41	0.33	0.20	0.55	0.79	0.24	-0.725331685219579	0.312090724656911	0.0820011838306987	0.385164511261231	6:39329989-39725405:-	KIF6	12;GO:0000166,molecular_function nucleotide binding;GO:0001673,cellular_component male germ cell nucleus;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity	NA	kinesin family member 6 [Source:HGNC Symbol%3BAcc:HGNC:21202]
ENSG00000189403	344.41	367.81	319.85	377.48	390.80	362.23	-0.12052228124448	7.86912703724063	0.0820095796103711	0.385164511261231	13:30456703-30617597:-	HMGB1	124;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000400,molecular_function four-way junction DNA binding;GO:0000405,molecular_function bubble DNA binding;GO:0000793,cellular_component condensed chromosome;GO:0001530,molecular_function lipopolysaccharide binding;GO:0001654,biological_process eye development;GO:0001773,biological_process myeloid dendritic cell activation;GO:0001786,molecular_function phosphatidylserine binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001935,biological_process endothelial cell proliferation;GO:0002218,biological_process activation of innate immune response;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002270,biological_process plasmacytoid dendritic cell activation;GO:0002281,biological_process macrophage activation involved in immune response;GO:0002376,biological_process immune system process;GO:0002407,biological_process dendritic cell chemotaxis;GO:0002437,biological_process inflammatory response to antigenic stimulus;GO:0002643,biological_process regulation of tolerance induction;GO:0002840,biological_process regulation of T cell mediated immune response to tumor cell;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005886,cellular_component plasma membrane;GO:0006265,biological_process DNA topological change;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006310,biological_process DNA recombination;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006914,biological_process autophagy;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008134,molecular_function transcription factor binding;GO:0008301,molecular_function DNA binding, bending;GO:0009986,cellular_component cell surface;GO:0010506,biological_process regulation of autophagy;GO:0010858,molecular_function calcium-dependent protein kinase regulator activity;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0017055,biological_process negative regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0019958,molecular_function C-X-C chemokine binding;GO:0030295,molecular_function protein kinase activator activity;GO:0030324,biological_process lung development;GO:0031175,biological_process neuron projection development;GO:0031497,biological_process chromatin assembly;GO:0032072,biological_process regulation of restriction endodeoxyribonuclease activity;GO:0032147,biological_process activation of protein kinase activity;GO:0032392,biological_process DNA geometric change;GO:0032425,biological_process positive regulation of mismatch repair;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0033151,biological_process V(D)J recombination;GO:0034137,biological_process positive regulation of toll-like receptor 2 signaling pathway;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0034165,biological_process positive regulation of toll-like receptor 9 signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0035711,biological_process T-helper 1 cell activation;GO:0035767,biological_process endothelial cell chemotaxis;GO:0042056,molecular_function chemoattractant activity;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043277,biological_process apoptotic cell clearance;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0043371,biological_process negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043388,biological_process positive regulation of DNA binding;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043537,biological_process negative regulation of blood vessel endothelial cell migration;GO:0045063,biological_process T-helper 1 cell differentiation;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0045639,biological_process positive regulation of myeloid cell differentiation;GO:0045819,biological_process positive regulation of glycogen catabolic process;GO:0045859,biological_process regulation of protein kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0050716,biological_process positive regulation of interleukin-1 secretion;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050786,molecular_function RAGE receptor binding;GO:0050918,biological_process positive chemotaxis;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0051106,biological_process positive regulation of DNA ligation;GO:0051384,biological_process response to glucocorticoid;GO:0070182,molecular_function DNA polymerase binding;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070491,molecular_function repressing transcription factor binding;GO:0090026,biological_process positive regulation of monocyte chemotaxis;GO:0090303,biological_process positive regulation of wound healing;GO:0097100,molecular_function supercoiled DNA binding;GO:0097350,biological_process neutrophil clearance;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1903672,biological_process positive regulation of sprouting angiogenesis;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1990774,biological_process tumor necrosis factor secretion;GO:2000426,biological_process negative regulation of apoptotic cell clearance;GO:2000778,biological_process positive regulation of interleukin-6 secretion;GO:2000819,biological_process regulation of nucleotide-excision repair;GO:2001200,biological_process positive regulation of dendritic cell differentiation	NA	high mobility group box 1 [Source:HGNC Symbol%3BAcc:HGNC:4983]
ENSG00000138035	14.04	13.92	13.02	11.95	12.39	13.24	0.134684883395655	4.96170263439441	0.0820099736778727	0.385164511261231	2:55634264-55693910:-	PNPT1	53;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000957,biological_process mitochondrial RNA catabolic process;GO:0000958,biological_process mitochondrial mRNA catabolic process;GO:0000962,biological_process positive regulation of mitochondrial RNA catabolic process;GO:0000964,biological_process mitochondrial RNA 5'-end processing;GO:0000965,biological_process mitochondrial RNA 3'-end processing;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004654,molecular_function polyribonucleotide nucleotidyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006401,biological_process RNA catabolic process;GO:0006402,biological_process mRNA catabolic process;GO:0006810,biological_process transport;GO:0008266,molecular_function poly(U) RNA binding;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016787,molecular_function hydrolase activity;GO:0034046,molecular_function poly(G) binding;GO:0034599,biological_process cellular response to oxidative stress;GO:0035198,molecular_function miRNA binding;GO:0035458,biological_process cellular response to interferon-beta;GO:0035927,biological_process RNA import into mitochondrion;GO:0035928,biological_process rRNA import into mitochondrion;GO:0042788,cellular_component polysomal ribosome;GO:0043457,biological_process regulation of cellular respiration;GO:0043631,biological_process RNA polyadenylation;GO:0045025,cellular_component mitochondrial degradosome;GO:0045926,biological_process negative regulation of growth;GO:0051260,biological_process protein homooligomerization;GO:0051591,biological_process response to cAMP;GO:0060416,biological_process response to growth hormone;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0070207,biological_process protein homotrimerization;GO:0070584,biological_process mitochondrion morphogenesis;GO:0071042,biological_process nuclear polyadenylation-dependent mRNA catabolic process;GO:0071850,biological_process mitotic cell cycle arrest;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0097222,biological_process mitochondrial mRNA polyadenylation;GO:0097421,biological_process liver regeneration;GO:2000627,biological_process positive regulation of miRNA catabolic process;GO:2000772,biological_process regulation of cellular senescence	pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]; K00962	polyribonucleotide nucleotidyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:23166]
ENSG00000135968	31.56	35.59	34.50	28.97	34.05	30.50	0.131393961587908	7.39451689355455	0.0820747254142792	0.385322831530805	2:108448560-108509415:+	GCC2	20;GO:0000042,biological_process protein targeting to Golgi;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006622,biological_process protein targeting to lysosome;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0031023,biological_process microtubule organizing center organization;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0034453,biological_process microtubule anchoring;GO:0034499,biological_process late endosome to Golgi transport;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042802,molecular_function identical protein binding;GO:0070861,biological_process regulation of protein exit from endoplasmic reticulum;GO:0071955,biological_process recycling endosome to Golgi transport;GO:0090161,biological_process Golgi ribbon formation	NA	GRIP and coiled-coil domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:23218]
ENSG00000170927	1.50	1.55	1.21	1.67	1.79	1.47	-0.202130085396195	4.23974971386418	0.0823531589063717	0.386483841778749	6:51615299-52087625:-	PKHD1	32;GO:0000775,cellular_component chromosome, centromeric region;GO:0001822,biological_process kidney development;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010824,biological_process regulation of centrosome duplication;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0032006,biological_process regulation of TOR signaling;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0036064,cellular_component ciliary basal body;GO:0042592,biological_process homeostatic process;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051271,biological_process negative regulation of cellular component movement;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0072686,cellular_component mitotic spindle	NA	PKHD1%2C fibrocystin/polyductin [Source:HGNC Symbol%3BAcc:HGNC:9016]
ENSG00000205213	17.72	18.08	17.36	15.95	17.33	16.04	0.119088925421364	5.61127826728568	0.0824071773947439	0.386591191610339	11:27365960-27472775:-	LGR4	39;GO:0001649,biological_process osteoblast differentiation;GO:0001942,biological_process hair follicle development;GO:0002376,biological_process immune system process;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007623,biological_process circadian rhythm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030154,biological_process cell differentiation;GO:0030282,biological_process bone mineralization;GO:0030539,biological_process male genitalia development;GO:0032922,biological_process circadian regulation of gene expression;GO:0034122,biological_process negative regulation of toll-like receptor signaling pathway;GO:0035239,biological_process tube morphogenesis;GO:0036335,biological_process intestinal stem cell homeostasis;GO:0045087,biological_process innate immune response;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046849,biological_process bone remodeling;GO:0048511,biological_process rhythmic process;GO:0048565,biological_process digestive tract development;GO:0050673,biological_process epithelial cell proliferation;GO:0050710,biological_process negative regulation of cytokine secretion;GO:0061290,biological_process canonical Wnt signaling pathway involved in metanephric kidney development;GO:0072202,biological_process cell differentiation involved in metanephros development;GO:0072224,biological_process metanephric glomerulus development;GO:0072282,biological_process metanephric nephron tubule morphogenesis;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:2001013,biological_process epithelial cell proliferation involved in renal tubule morphogenesis	LGR4, GPR48; leucine-rich repeat-containing G protein-coupled receptor 4; K04309	leucine rich repeat containing G protein-coupled receptor 4 [Source:HGNC Symbol%3BAcc:HGNC:13299]
ENSG00000166145	0.56	0.81	0.66	1.23	0.68	1.07	-0.563932593937128	0.70837730339401	0.0825734874980351	0.387098343702105	15:40844017-40858207:+	SPINT1	18;GO:0001843,biological_process neural tube closure;GO:0001892,biological_process embryonic placenta development;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0030414,molecular_function peptidase inhibitor activity;GO:0045687,biological_process positive regulation of glial cell differentiation;GO:0060670,biological_process branching involved in labyrinthine layer morphogenesis;GO:0060674,biological_process placenta blood vessel development;GO:0070062,cellular_component extracellular exosome;GO:0071773,biological_process cellular response to BMP stimulus;GO:2000178,biological_process negative regulation of neural precursor cell proliferation	SPINT1; Kunitz-type protease inhibitor 1; K15619	serine peptidase inhibitor%2C Kunitz type 1 [Source:HGNC Symbol%3BAcc:HGNC:11246]
ENSG00000154832	19.48	19.90	18.85	17.14	17.86	18.76	0.124666049996409	5.21564422176269	0.0826078716074735	0.387098343702105	18:50282342-50288304:-	CXXC1	19;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0035097,cellular_component histone methyltransferase complex;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0045322,molecular_function unmethylated CpG binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation	NA	CXXC finger protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24343]
ENSG00000149823	14.49	15.49	15.50	14.90	12.90	13.97	0.132707740008384	5.33087159119341	0.0826354352332401	0.387098343702105	11:65089323-65111860:+	VPS51	24;GO:0000938,cellular_component GARP complex;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006914,biological_process autophagy;GO:0007030,biological_process Golgi organization;GO:0007041,biological_process lysosomal transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032456,biological_process endocytic recycling;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048193,biological_process Golgi vesicle transport;GO:0055037,cellular_component recycling endosome;GO:1990745,cellular_component EARP complex	NA	VPS51%2C GARP complex subunit [Source:HGNC Symbol%3BAcc:HGNC:1172]
ENSG00000147894	5.04	5.10	5.00	4.20	4.78	3.85	0.25133481038575	2.77814322473828	0.0826400234279044	0.387098343702105	9:27546544-27573866:-	C9orf72	20;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005776,cellular_component autophagosome;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0010506,biological_process regulation of autophagy;GO:0016239,biological_process positive regulation of macroautophagy;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032045,cellular_component guanyl-nucleotide exchange factor complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:1903432,biological_process regulation of TORC1 signaling;GO:1990316,cellular_component ATG1/ULK1 kinase complex	NA	chromosome 9 open reading frame 72 [Source:HGNC Symbol%3BAcc:HGNC:28337]
ENSG00000091140	79.81	81.71	76.17	71.14	79.03	70.27	0.119947066197249	6.88442896430634	0.0828115692658019	0.387680034751139	7:107890969-107931730:+	DLD	38;GO:0001669,cellular_component acrosomal vesicle;GO:0004148,molecular_function dihydrolipoyl dehydrogenase activity;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005929,cellular_component cilium;GO:0006086,biological_process acetyl-CoA biosynthetic process from pyruvate;GO:0006090,biological_process pyruvate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006508,biological_process proteolysis;GO:0006554,biological_process lysine catabolic process;GO:0007369,biological_process gastrulation;GO:0007568,biological_process aging;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0009106,biological_process lipoate metabolic process;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016491,molecular_function oxidoreductase activity;GO:0016668,molecular_function oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031514,cellular_component motile cilium;GO:0034604,molecular_function pyruvate dehydrogenase (NAD+) activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0042391,biological_process regulation of membrane potential;GO:0042995,cellular_component cell projection;GO:0043159,cellular_component acrosomal matrix;GO:0043209,cellular_component myelin sheath;GO:0043544,molecular_function lipoamide binding;GO:0045252,cellular_component oxoglutarate dehydrogenase complex;GO:0045254,cellular_component pyruvate dehydrogenase complex;GO:0045454,biological_process cell redox homeostasis;GO:0048240,biological_process sperm capacitation;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051068,biological_process dihydrolipoamide metabolic process;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0061732,biological_process mitochondrial acetyl-CoA biosynthetic process from pyruvate	DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]; K00382	dihydrolipoamide dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:2898]
ENSG00000140987	8.99	7.91	10.12	10.40	9.65	10.82	-0.173460682276559	4.38372259619356	0.0828280177799029	0.387680034751139	16:3382080-3401065:-	ZSCAN32	11;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger and SCAN domain containing 32 [Source:HGNC Symbol%3BAcc:HGNC:20812]
ENSG00000197808	4.59	5.63	4.90	5.52	5.43	7.05	-0.251381087377235	3.34797101860654	0.0828579015705126	0.387680034751139	19:36637191-36666853:-	ZNF461	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 461 [Source:HGNC Symbol%3BAcc:HGNC:21629]
ENSG00000184281	16.53	17.14	15.29	18.36	18.52	18.31	-0.165376744866922	4.11194179480533	0.0829620453210361	0.387892227439788	11:2400487-2403878:+	TSSC4	1;GO:0005515,molecular_function protein binding	NA	tumor suppressing subtransferable candidate 4 [Source:HGNC Symbol%3BAcc:HGNC:12386]
ENSG00000092978	7.79	8.82	7.75	7.42	7.24	6.75	0.190979868960259	3.63407349557826	0.0829953076400403	0.387892227439788	1:217426991-217631082:-	GPATCH2	5;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016607,cellular_component nuclear speck	NA	G-patch domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25499]
ENSG00000102978	46.03	40.10	40.23	48.53	46.40	45.32	-0.134751745209915	5.20853124375017	0.0830451216712625	0.387892227439788	16:57462386-57472010:+	POLR2C	24;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001055,molecular_function RNA polymerase II activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016070,biological_process RNA metabolic process;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB3, POLR2C; DNA-directed RNA polymerase II subunit RPB3; K03011	RNA polymerase II subunit C [Source:HGNC Symbol%3BAcc:HGNC:9189]
ENSG00000100764	106.26	107.73	104.05	117.47	113.53	113.89	-0.105679074074755	7.19070346958077	0.0830626011769964	0.387892227439788	14:90256494-90275429:+	PSMC1	49;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006457,biological_process protein folding;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017025,molecular_function TBP-class protein binding;GO:0022624,cellular_component proteasome accessory complex;GO:0030163,biological_process protein catabolic process;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031595,cellular_component nuclear proteasome complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0036402,molecular_function proteasome-activating ATPase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901215,biological_process negative regulation of neuron death;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMC1, RPT2; 26S proteasome regulatory subunit T2; K03062	proteasome 26S subunit%2C ATPase 1 [Source:HGNC Symbol%3BAcc:HGNC:9547]
ENSG00000129667	17.89	15.65	18.25	16.29	13.85	16.90	0.153762534178791	5.4290601210294	0.0831205614375685	0.387892227439788	17:76470890-76501790:-	RHBDF2	15;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0008233,molecular_function peptidase activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019838,molecular_function growth factor binding;GO:0042058,biological_process regulation of epidermal growth factor receptor signaling pathway;GO:0050708,biological_process regulation of protein secretion;GO:0050709,biological_process negative regulation of protein secretion	NA	rhomboid 5 homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:20788]
ENSG00000103260	21.06	24.00	20.46	18.39	17.51	22.14	0.179102334888411	4.48569426389014	0.0831387959099897	0.387892227439788	16:715114-719655:+	METRN	7;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0010001,biological_process glial cell differentiation;GO:0030154,biological_process cell differentiation;GO:0050772,biological_process positive regulation of axonogenesis	NA	meteorin%2C glial cell differentiation regulator [Source:HGNC Symbol%3BAcc:HGNC:14151]
ENSG00000132879	15.68	11.63	18.10	14.56	11.51	11.82	0.283958286565602	3.49575212864764	0.0831587395973623	0.387892227439788	1:11654374-11663327:+	FBXO44	7;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0010498,biological_process proteasomal protein catabolic process;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification	NA	F-box protein 44 [Source:HGNC Symbol%3BAcc:HGNC:24847]
ENSG00000134283	42.89	47.07	39.64	46.30	49.76	46.64	-0.130034230431162	6.35711281159447	0.0832088805538917	0.387892227439788	12:42238446-42459715:+	PPHLN1	11;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031424,biological_process keratinization	NA	periphilin 1 [Source:HGNC Symbol%3BAcc:HGNC:19369]
ENSG00000013306	97.64	105.47	98.65	91.65	97.69	91.59	0.113678252470282	6.8509034790832	0.0832098241468367	0.387892227439788	17:44319624-44324870:-	SLC25A39	9;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006783,biological_process heme biosynthetic process;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 39 [Source:HGNC Symbol%3BAcc:HGNC:24279]
ENSG00000143476	8.87	9.08	8.60	10.15	9.52	9.99	-0.150939932339578	4.37087506021451	0.0832248579592728	0.387892227439788	1:212035552-212107400:+	DTL	27;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006260,biological_process DNA replication;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0019985,biological_process translesion synthesis;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0031465,cellular_component Cul4B-RING E3 ubiquitin ligase complex;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031965,cellular_component nuclear membrane;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043687,biological_process post-translational protein modification;GO:0051726,biological_process regulation of cell cycle	NA	denticleless E3 ubiquitin protein ligase homolog [Source:HGNC Symbol%3BAcc:HGNC:30288]
ENSG00000084734	8.80	8.86	9.28	10.62	10.01	9.70	-0.1570831533871	4.29536918771713	0.0832638939360128	0.387892227439788	2:27496841-27523684:+	GCKR	26;GO:0000060,biological_process protein import into nucleus, translocation;GO:0001678,biological_process cellular glucose homeostasis;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006110,biological_process regulation of glycolytic process;GO:0009750,biological_process response to fructose;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030246,molecular_function carbohydrate binding;GO:0033132,biological_process negative regulation of glucokinase activity;GO:0033133,biological_process positive regulation of glucokinase activity;GO:0034504,biological_process protein localization to nucleus;GO:0043086,biological_process negative regulation of catalytic activity;GO:0046415,biological_process urate metabolic process;GO:0070095,molecular_function fructose-6-phosphate binding;GO:0070328,biological_process triglyceride homeostasis;GO:0097367,molecular_function carbohydrate derivative binding;GO:1901135,biological_process carbohydrate derivative metabolic process	NA	glucokinase regulator [Source:HGNC Symbol%3BAcc:HGNC:4196]
ENSG00000103978	16.40	16.76	16.30	17.21	17.91	19.68	-0.138835736109254	4.95902385070268	0.0832782394366419	0.387892227439788	15:42210451-42273663:-	TMEM87A	4;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032580,cellular_component Golgi cisterna membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi	NA	transmembrane protein 87A [Source:HGNC Symbol%3BAcc:HGNC:24522]
ENSG00000100410	56.71	63.71	62.00	71.24	62.05	72.66	-0.168651312867147	4.42819767219682	0.083439899382449	0.388499426494501	22:41459716-41468725:-	PHF5A	18;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	PHD finger protein 5A [Source:HGNC Symbol%3BAcc:HGNC:18000]
ENSG00000135164	35.64	35.31	38.28	30.80	34.49	35.76	0.124619776515177	6.46183751095981	0.0835772680743971	0.388901512545587	7:87152360-87196337:+	DMTF1	14;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001135,molecular_function transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding	NA	cyclin D binding myb like transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:14603]
ENSG00000138660	30.91	25.72	29.88	31.05	31.61	34.54	-0.149871315740608	4.82005647526023	0.083602211093628	0.388901512545587	4:112231736-112270047:+	AP1AR	16;GO:0001920,biological_process negative regulation of receptor recycling;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0019894,molecular_function kinesin binding;GO:0030133,cellular_component transport vesicle;GO:0034315,biological_process regulation of Arp2/3 complex-mediated actin nucleation;GO:0034613,biological_process cellular protein localization;GO:0035650,molecular_function AP-1 adaptor complex binding;GO:0048203,biological_process vesicle targeting, trans-Golgi to endosome;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:2000146,biological_process negative regulation of cell motility	NA	adaptor related protein complex 1 associated regulatory protein [Source:HGNC Symbol%3BAcc:HGNC:28808]
ENSG00000065325	1.11	1.27	1.51	1.98	1.55	1.69	-0.418458752518502	1.42467993266664	0.0836202478840064	0.388901512545587	17:9822205-9892102:+	GLP2R	13;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004967,molecular_function glucagon receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0071377,biological_process cellular response to glucagon stimulus	GLP2R; glucagon-like peptide 2 receptor; K04582	glucagon like peptide 2 receptor [Source:HGNC Symbol%3BAcc:HGNC:4325]
ENSG00000171914	5.15	5.56	5.45	5.80	5.90	5.98	-0.121212104991307	5.47130754492765	0.0837055767265725	0.389152555770391	15:62390525-62844631:+	TLN2	18;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007043,biological_process cell-cell junction assembly;GO:0007155,biological_process cell adhesion;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0051015,molecular_function actin filament binding	TLN; talin; K06271	talin 2 [Source:HGNC Symbol%3BAcc:HGNC:15447]
ENSG00000170144	286.80	300.01	262.15	295.99	337.95	300.99	-0.127804853867181	8.39855008177455	0.0837568479083983	0.38924513406475	2:177212562-177223958:+	HNRNPA3	20;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016070,biological_process RNA metabolic process;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035770,cellular_component ribonucleoprotein granule;GO:0043005,cellular_component neuron projection;GO:0051028,biological_process mRNA transport;GO:0051033,molecular_function RNA transmembrane transporter activity;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1990124,cellular_component messenger ribonucleoprotein complex	HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3; K12741	heterogeneous nuclear ribonucleoprotein A3 [Source:HGNC Symbol%3BAcc:HGNC:24941]
ENSG00000128602	27.29	29.22	27.33	24.43	26.28	27.11	0.116486452954144	6.00646602280857	0.0838293225614663	0.389348862269627	7:129188871-129213545:+	SMO	97;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001503,biological_process ossification;GO:0001570,biological_process vasculogenesis;GO:0001649,biological_process osteoblast differentiation;GO:0001701,biological_process in utero embryonic development;GO:0001708,biological_process cell fate specification;GO:0001755,biological_process neural crest cell migration;GO:0001947,biological_process heart looping;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0003007,biological_process heart morphogenesis;GO:0003140,biological_process determination of left/right asymmetry in lateral mesoderm;GO:0003323,biological_process type B pancreatic cell development;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005113,molecular_function patched binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005929,cellular_component cilium;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007224,biological_process smoothened signaling pathway;GO:0007228,biological_process positive regulation of hh target transcription factor activity;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007371,biological_process ventral midline determination;GO:0007389,biological_process pattern specification process;GO:0007417,biological_process central nervous system development;GO:0007494,biological_process midgut development;GO:0008144,molecular_function drug binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017147,molecular_function Wnt-protein binding;GO:0021542,biological_process dentate gyrus development;GO:0021696,biological_process cerebellar cortex morphogenesis;GO:0021794,biological_process thalamus development;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021910,biological_process smoothened signaling pathway involved in ventral spinal cord patterning;GO:0021938,biological_process smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation;GO:0021953,biological_process central nervous system neuron differentiation;GO:0021987,biological_process cerebral cortex development;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030857,biological_process negative regulation of epithelial cell differentiation;GO:0031069,biological_process hair follicle morphogenesis;GO:0034504,biological_process protein localization to nucleus;GO:0035264,biological_process multicellular organism growth;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043392,biological_process negative regulation of DNA binding;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046622,biological_process positive regulation of organ growth;GO:0048143,biological_process astrocyte activation;GO:0048468,biological_process cell development;GO:0048565,biological_process digestive tract development;GO:0048568,biological_process embryonic organ development;GO:0048589,biological_process developmental growth;GO:0048741,biological_process skeletal muscle fiber development;GO:0048853,biological_process forebrain morphogenesis;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050821,biological_process protein stabilization;GO:0051451,biological_process myoblast migration;GO:0051799,biological_process negative regulation of hair follicle development;GO:0060170,cellular_component ciliary membrane;GO:0060248,biological_process detection of cell density by contact stimulus involved in contact inhibition;GO:0060413,biological_process atrial septum morphogenesis;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0060684,biological_process epithelial-mesenchymal cell signaling;GO:0061053,biological_process somite development;GO:0061113,biological_process pancreas morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070986,biological_process left/right axis specification;GO:0071397,biological_process cellular response to cholesterol;GO:0072001,biological_process renal system development;GO:0072285,biological_process mesenchymal to epithelial transition involved in metanephric renal vesicle formation;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0097542,cellular_component ciliary tip;GO:2000036,biological_process regulation of stem cell population maintenance;GO:2000826,biological_process regulation of heart morphogenesis	SMO; smoothened; K06226	smoothened%2C frizzled class receptor [Source:HGNC Symbol%3BAcc:HGNC:11119]
ENSG00000170871	15.69	15.21	14.86	14.26	14.06	14.47	0.108822688898482	5.9529033346218	0.0838918021937283	0.389348862269627	4:6781374-6884170:+	KIAA0232	2;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding	NA	KIAA0232 [Source:HGNC Symbol%3BAcc:HGNC:28992]
ENSG00000109103	19.56	20.36	17.16	15.76	18.34	16.13	0.191865250269269	3.84596571238014	0.0839033754046329	0.389348862269627	17:28546706-28552668:-	UNC119	24;GO:0000281,biological_process mitotic cytokinesis;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0007268,biological_process chemical synaptic transmission;GO:0007601,biological_process visual perception;GO:0007602,biological_process phototransduction;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0030182,biological_process neuron differentiation;GO:0042953,biological_process lipoprotein transport;GO:0045171,cellular_component intercellular bridge;GO:0050896,biological_process response to stimulus;GO:0051233,cellular_component spindle midzone;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:1900186,biological_process negative regulation of clathrin-mediated endocytosis;GO:2001287,biological_process negative regulation of caveolin-mediated endocytosis	NA	unc-119 lipid binding chaperone [Source:HGNC Symbol%3BAcc:HGNC:12565]
ENSG00000185115	17.58	17.19	22.27	21.02	21.54	23.21	-0.189030276120599	4.2398115083896	0.0839316577974531	0.389348862269627	15:29264991-29269829:-	NSMCE3	16;GO:0000781,cellular_component chromosome, telomeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0030915,cellular_component Smc5-Smc6 complex;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0034644,biological_process cellular response to UV;GO:0040008,biological_process regulation of growth;GO:0046983,molecular_function protein dimerization activity;GO:0071478,biological_process cellular response to radiation;GO:0072711,biological_process cellular response to hydroxyurea	NA	NSE3 homolog%2C SMC5-SMC6 complex component [Source:HGNC Symbol%3BAcc:HGNC:7677]
ENSG00000155096	69.15	62.00	59.58	68.47	70.37	70.37	-0.120465281288678	6.48934754792703	0.0839359989876356	0.389348862269627	8:102826356-102893864:-	AZIN1	12;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0033387,biological_process putrescine biosynthetic process from ornithine;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042978,molecular_function ornithine decarboxylase activator activity;GO:0043085,biological_process positive regulation of catalytic activity;GO:1902269,biological_process positive regulation of polyamine transmembrane transport	NA	antizyme inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:16432]
ENSG00000171368	1.29	1.89	1.68	2.74	2.08	2.35	-0.566277165103596	0.555231539105614	0.0840045127566156	0.389369535995776	5:659861-693395:-	TPPP	16;GO:0001578,biological_process microtubule bundle formation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0015631,molecular_function tubulin binding;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0032273,biological_process positive regulation of protein polymerization;GO:0043209,cellular_component myelin sheath;GO:0046785,biological_process microtubule polymerization;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0097427,cellular_component microtubule bundle	NA	tubulin polymerization promoting protein [Source:HGNC Symbol%3BAcc:HGNC:24164]
ENSG00000158615	28.10	27.70	27.36	26.08	25.85	25.81	0.109117912606528	5.84613921153277	0.0840646810283862	0.389369535995776	1:204403386-204411791:-	PPP1R15B	13;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0006417,biological_process regulation of translation;GO:0006979,biological_process response to oxidative stress;GO:0006983,biological_process ER overload response;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042542,biological_process response to hydrogen peroxide;GO:0050790,biological_process regulation of catalytic activity;GO:0070262,biological_process peptidyl-serine dephosphorylation;GO:1903898,biological_process negative regulation of PERK-mediated unfolded protein response;GO:1903912,biological_process negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	NA	protein phosphatase 1 regulatory subunit 15B [Source:HGNC Symbol%3BAcc:HGNC:14951]
ENSG00000178537	6.30	7.73	6.11	4.74	6.69	4.89	0.306411261352131	2.57380712429586	0.0840724660751997	0.389369535995776	3:48856930-48898993:-	SLC25A20	14;GO:0005476,molecular_function carnitine:acyl carnitine antiporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0006853,biological_process carnitine shuttle;GO:0015226,molecular_function carnitine transmembrane transporter activity;GO:0015227,molecular_function acyl carnitine transmembrane transporter activity;GO:0015879,biological_process carnitine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1902603,biological_process carnitine transmembrane transport;GO:1902616,biological_process acyl carnitine transmembrane transport	SLC25A20_29, CACT, CACL, CRC1; solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter), member 20/29; K15109	solute carrier family 25 member 20 [Source:HGNC Symbol%3BAcc:HGNC:1421]
ENSG00000100360	28.04	31.43	29.55	24.96	26.40	28.54	0.160864291546572	4.25709505470528	0.0841048903727558	0.389369535995776	22:36758201-36776256:-	IFT27	22;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007224,biological_process smoothened signaling pathway;GO:0015031,biological_process protein transport;GO:0030992,cellular_component intraciliary transport particle B;GO:0031514,cellular_component motile cilium;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0090102,biological_process cochlea development;GO:0097225,cellular_component sperm midpiece;GO:0097228,cellular_component sperm principal piece;GO:0097542,cellular_component ciliary tip	NA	intraflagellar transport 27 [Source:HGNC Symbol%3BAcc:HGNC:18626]
ENSG00000111077	12.52	12.04	12.29	11.95	11.55	10.68	0.121897120822216	5.6944032080299	0.0841167662600755	0.389369535995776	12:53046968-53064372:+	TNS2	19;GO:0001822,biological_process kidney development;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006470,biological_process protein dephosphorylation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014850,biological_process response to muscle activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019725,biological_process cellular homeostasis;GO:0019900,molecular_function kinase binding;GO:0030054,cellular_component cell junction;GO:0032963,biological_process collagen metabolic process;GO:0035264,biological_process multicellular organism growth;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:0048871,biological_process multicellular organismal homeostasis	NA	tensin 2 [Source:HGNC Symbol%3BAcc:HGNC:19737]
ENSG00000165389	89.19	103.64	98.83	91.74	91.87	74.28	0.186480490792282	4.2924569822469	0.084128663138699	0.389369535995776	14:34432788-34462356:-	SPTSSA	11;GO:0004758,molecular_function serine C-palmitoyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017059,cellular_component serine C-palmitoyltransferase complex;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0046513,biological_process ceramide biosynthetic process	NA	serine palmitoyltransferase small subunit A [Source:HGNC Symbol%3BAcc:HGNC:20361]
ENSG00000198039	2.52	2.93	2.79	3.38	3.17	3.45	-0.276873702231508	2.4882356632926	0.0842231805897888	0.389535967390264	7:64870171-64930966:+	ZNF273	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 273 [Source:HGNC Symbol%3BAcc:HGNC:13067]
ENSG00000131370	19.78	22.03	22.71	19.50	20.08	19.23	0.143107982957199	4.82290841345052	0.0842419096815958	0.389535967390264	3:15254852-15341368:-	SH3BP5	10;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007165,biological_process signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0035556,biological_process intracellular signal transduction;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity	NA	SH3 domain binding protein 5 [Source:HGNC Symbol%3BAcc:HGNC:10827]
ENSG00000163634	136.75	143.82	132.41	146.20	154.66	149.14	-0.113757019799211	6.46285135487619	0.0842719474880236	0.389535967390264	3:63833869-63863903:-	THOC7	20;GO:0000346,cellular_component transcription export complex;GO:0000347,cellular_component THO complex;GO:0000445,cellular_component THO complex part of transcription export complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0046784,biological_process viral mRNA export from host cell nucleus;GO:0051028,biological_process mRNA transport	THOC7; THO complex subunit 7; K13176	THO complex 7 [Source:HGNC Symbol%3BAcc:HGNC:29874]
ENSG00000168137	37.48	34.56	38.60	35.51	33.21	34.43	0.113997377056551	7.40085071213933	0.0842901481036212	0.389535967390264	3:9397614-9479240:+	SETD5	5;GO:0005634,cellular_component nucleus;GO:0016569,biological_process covalent chromatin modification;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0035065,biological_process regulation of histone acetylation;GO:1902275,biological_process regulation of chromatin organization	NA	SET domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:25566]
ENSG00000170759	40.63	40.85	40.51	36.67	37.62	39.77	0.108304225255505	6.83121606156442	0.0843356634023003	0.389601261560385	10:32009009-32056431:-	KIF5B	43;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0007028,biological_process cytoplasm organization;GO:0007411,biological_process axon guidance;GO:0007420,biological_process brain development;GO:0008017,molecular_function microtubule binding;GO:0008432,molecular_function JUN kinase binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0021766,biological_process hippocampus development;GO:0030139,cellular_component endocytic vesicle;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031340,biological_process positive regulation of vesicle fusion;GO:0031982,cellular_component vesicle;GO:0032230,biological_process positive regulation of synaptic transmission, GABAergic;GO:0035253,cellular_component ciliary rootlet;GO:0035617,biological_process stress granule disassembly;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042391,biological_process regulation of membrane potential;GO:0043005,cellular_component neuron projection;GO:0043227,cellular_component membrane-bounded organelle;GO:0043268,biological_process positive regulation of potassium ion transport;GO:0044295,cellular_component axonal growth cone;GO:0045296,molecular_function cadherin binding;GO:0047496,biological_process vesicle transport along microtubule;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051642,biological_process centrosome localization;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0099609,molecular_function microtubule lateral binding;GO:1905152,biological_process positive regulation of voltage-gated sodium channel activity	KIF5; kinesin family member 5; K10396	kinesin family member 5B [Source:HGNC Symbol%3BAcc:HGNC:6324]
ENSG00000181458	8.66	7.22	6.32	5.92	6.95	5.32	0.305876445635295	2.58972923761931	0.0843923081803908	0.389717902322615	3:100492618-100577444:+	TMEM45A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 45A [Source:HGNC Symbol%3BAcc:HGNC:25480]
ENSG00000132768	11.44	10.54	12.06	10.36	10.58	9.68	0.171126400014747	4.12662097980372	0.0845123146041585	0.390126947259732	1:43969999-43973369:+	DPH2	5;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0016740,molecular_function transferase activity;GO:0017183,biological_process peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0090560,molecular_function 2-(3-amino-3-carboxypropyl)histidine synthase activity	NA	DPH2 homolog [Source:HGNC Symbol%3BAcc:HGNC:3004]
ENSG00000142867	34.15	24.47	26.01	32.99	32.66	32.39	-0.192022968956277	4.42921936540587	0.0846463643168955	0.390600490805065	1:85266247-85277090:-	BCL10	67;GO:0001772,cellular_component immunological synapse;GO:0001783,biological_process B cell apoptotic process;GO:0001843,biological_process neural tube closure;GO:0002020,molecular_function protease binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002237,biological_process response to molecule of bacterial origin;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002906,biological_process negative regulation of mature B cell apoptotic process;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006968,biological_process cellular defense response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008219,biological_process cell death;GO:0009620,biological_process response to fungus;GO:0016020,cellular_component membrane;GO:0016064,biological_process immunoglobulin mediated immune response;GO:0016567,biological_process protein ubiquitination;GO:0019209,molecular_function kinase activator activity;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032094,biological_process response to food;GO:0032449,cellular_component CBM complex;GO:0032765,biological_process positive regulation of mast cell cytokine production;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042101,cellular_component T cell receptor complex;GO:0042109,biological_process lymphotoxin A biosynthetic process;GO:0042226,biological_process interleukin-6 biosynthetic process;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043422,molecular_function protein kinase B binding;GO:0043621,molecular_function protein self-association;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045416,biological_process positive regulation of interleukin-8 biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046696,cellular_component lipopolysaccharide receptor complex;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050856,biological_process regulation of T cell receptor signaling pathway;GO:0050870,biological_process positive regulation of T cell activation;GO:0051059,molecular_function NF-kappaB binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051259,biological_process protein oligomerization;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization;GO:0070231,biological_process T cell apoptotic process;GO:0071260,biological_process cellular response to mechanical stimulus;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	BCL10; B-cell CLL/lymphoma 10; K07368	B-cell CLL/lymphoma 10 [Source:HGNC Symbol%3BAcc:HGNC:989]
ENSG00000198825	2.43	2.02	2.29	2.45	2.40	3.29	-0.256721803019679	3.26515608246294	0.0846985933632165	0.390615303854213	10:119726096-119829278:+	INPP5F	36;GO:0001921,biological_process positive regulation of receptor recycling;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005905,cellular_component clathrin-coated pit;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008344,biological_process adult locomotory behavior;GO:0008934,molecular_function inositol monophosphate 1-phosphatase activity;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031161,biological_process phosphatidylinositol catabolic process;GO:0031901,cellular_component early endosome membrane;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034595,molecular_function phosphatidylinositol phosphate 5-phosphatase activity;GO:0034596,molecular_function phosphatidylinositol phosphate 4-phosphatase activity;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0042578,molecular_function phosphoric ester hydrolase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048681,biological_process negative regulation of axon regeneration;GO:0051896,biological_process regulation of protein kinase B signaling;GO:0052832,molecular_function inositol monophosphate 3-phosphatase activity;GO:0052833,molecular_function inositol monophosphate 4-phosphatase activity;GO:0052834,molecular_function inositol monophosphate phosphatase activity;GO:0055037,cellular_component recycling endosome;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly;GO:0072583,biological_process clathrin-mediated endocytosis;GO:2000145,biological_process regulation of cell motility;GO:2001135,biological_process regulation of endocytic recycling	NA	inositol polyphosphate-5-phosphatase F [Source:HGNC Symbol%3BAcc:HGNC:17054]
ENSG00000178093	2.16	1.75	3.50	3.57	2.96	3.86	-0.453557892345135	1.3889090844863	0.0847125109140048	0.390615303854213	19:19512417-19515685:-	TSSK6	18;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0035092,biological_process sperm chromatin condensation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	testis specific serine kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:30410]
ENSG00000143158	257.66	303.50	242.63	222.06	273.51	226.83	0.164021213401623	6.59934991538197	0.084760604925682	0.390666195648707	1:167916728-167937040:-	MPC2	12;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006850,biological_process mitochondrial pyruvate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0050833,molecular_function pyruvate transmembrane transporter activity;GO:0061732,biological_process mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:1902361,biological_process mitochondrial pyruvate transmembrane transport	NA	mitochondrial pyruvate carrier 2 [Source:HGNC Symbol%3BAcc:HGNC:24515]
ENSG00000174243	44.55	48.38	41.73	47.78	52.34	47.90	-0.126096962720193	7.08700753176948	0.0847864924738271	0.390666195648707	12:48829763-48852842:-	DDX23	22;GO:0000166,molecular_function nucleotide binding;GO:0000354,biological_process cis assembly of pre-catalytic spliceosome;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	DEAD-box helicase 23 [Source:HGNC Symbol%3BAcc:HGNC:17347]
ENSG00000181789	97.50	110.96	91.40	90.25	97.74	86.96	0.136116454835537	8.00967931901859	0.0848517231605661	0.390821684449761	3:129249605-129277773:+	COPG1	21;GO:0000139,cellular_component Golgi membrane;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0051683,biological_process establishment of Golgi localization;GO:0072384,biological_process organelle transport along microtubule	NA	coatomer protein complex subunit gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:2236]
ENSG00000066027	46.86	49.61	51.49	46.77	44.38	46.61	0.113987935583296	6.13080106717435	0.0849380969559856	0.391074405606324	1:212285536-212361863:+	PPP2R5A	16;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0019900,molecular_function kinase binding;GO:0030018,cellular_component Z disc;GO:0031430,cellular_component M band;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0090005,biological_process negative regulation of establishment of protein localization to plasma membrane;GO:0090219,biological_process negative regulation of lipid kinase activity	PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'; K11584	protein phosphatase 2 regulatory subunit B'alpha [Source:HGNC Symbol%3BAcc:HGNC:9309]
ENSG00000071127	183.38	195.05	177.33	203.29	214.52	189.98	-0.11780799010909	8.49133349727527	0.0850048176991787	0.391236485761922	4:10074338-10116949:-	WDR1	33;GO:0002102,cellular_component podosome;GO:0002446,biological_process neutrophil mediated immunity;GO:0002576,biological_process platelet degranulation;GO:0003779,molecular_function actin binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005911,cellular_component cell-cell junction;GO:0007605,biological_process sensory perception of sound;GO:0008360,biological_process regulation of cell shape;GO:0030036,biological_process actin cytoskeleton organization;GO:0030043,biological_process actin filament fragmentation;GO:0030054,cellular_component cell junction;GO:0030220,biological_process platelet formation;GO:0030834,biological_process regulation of actin filament depolymerization;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0030865,biological_process cortical cytoskeleton organization;GO:0040011,biological_process locomotion;GO:0042247,biological_process establishment of planar polarity of follicular epithelium;GO:0042643,cellular_component actomyosin, actin portion;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0043297,biological_process apical junction assembly;GO:0045199,biological_process maintenance of epithelial cell apical/basal polarity;GO:0045214,biological_process sarcomere organization;GO:0048713,biological_process regulation of oligodendrocyte differentiation;GO:0051015,molecular_function actin filament binding;GO:0060307,biological_process regulation of ventricular cardiac muscle cell membrane repolarization;GO:0070062,cellular_component extracellular exosome;GO:1990266,biological_process neutrophil migration	NA	WD repeat domain 1 [Source:HGNC Symbol%3BAcc:HGNC:12754]
ENSG00000243749	50.14	51.51	54.64	59.64	54.83	59.66	-0.144516024394227	4.68016309456513	0.0850898720535496	0.391307155963236	1:34981534-34985353:-	TMEM35B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 35B [Source:HGNC Symbol%3BAcc:HGNC:40021]
ENSG00000271949	12.22	8.58	11.80	10.56	15.56	19.83	-0.466297755168506	1.15489260632975	0.0851172400527317	0.391307155963236	1:89633139-89933250:+	AC093423.3	NA	NA	NA
ENSG00000198804	13144.52	14389.91	13570.63	12317.39	13633.36	12347.84	0.113849757160261	14.3152600944644	0.0851236120764681	0.391307155963236	MT:5903-7445:+	MT-CO1	26;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006119,biological_process oxidative phosphorylation;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0006979,biological_process response to oxidative stress;GO:0007568,biological_process aging;GO:0009055,molecular_function electron carrier activity;GO:0009060,biological_process aerobic respiration;GO:0015990,biological_process electron transport coupled proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0020037,molecular_function heme binding;GO:0021549,biological_process cerebellum development;GO:0045277,cellular_component respiratory chain complex IV;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0051602,biological_process response to electrical stimulus;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	COX1; cytochrome c oxidase subunit 1 [EC:1.9.3.1]; K02256	mitochondrially encoded cytochrome c oxidase I [Source:HGNC Symbol%3BAcc:HGNC:7419]
ENSG00000087510	2.13	2.25	3.30	1.98	2.23	1.60	0.422653815833142	1.68080347852817	0.0851462682878192	0.391307155963236	20:56629301-56639283:+	TFAP2C	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007267,biological_process cell-cell signaling;GO:0008584,biological_process male gonad development;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042127,biological_process regulation of cell proliferation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity	NA	transcription factor AP-2 gamma [Source:HGNC Symbol%3BAcc:HGNC:11744]
ENSG00000255974	0.76	0.38	0.89	0.30	0.51	0.42	0.764414004011599	-0.0365142108928982	0.0852491690551472	0.391635061244094	19:40843537-40850447:-	CYP2A6	25;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005881,cellular_component cytoplasmic microtubule;GO:0008202,biological_process steroid metabolic process;GO:0008389,molecular_function coumarin 7-hydroxylase activity;GO:0008392,molecular_function arachidonic acid epoxygenase activity;GO:0008395,molecular_function steroid hydroxylase activity;GO:0009804,biological_process coumarin metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016712,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0017144,biological_process drug metabolic process;GO:0019373,biological_process epoxygenase P450 pathway;GO:0019899,molecular_function enzyme binding;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0042738,biological_process exogenous drug catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046226,biological_process coumarin catabolic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	CYP2A; cytochrome P450 family 2 subfamily A [EC:1.14.14.1]; K07411	cytochrome P450 family 2 subfamily A member 6 [Source:HGNC Symbol%3BAcc:HGNC:2610]
ENSG00000075975	22.13	19.14	21.17	23.76	23.88	22.14	-0.141550877914805	4.79353467294029	0.0853168140168062	0.391687920606979	3:12557013-12583713:+	MKRN2	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	makorin ring finger protein 2 [Source:HGNC Symbol%3BAcc:HGNC:7113]
ENSG00000128311	29.65	29.50	26.52	23.28	26.56	27.46	0.157110735421405	4.60489687079847	0.0853237845260026	0.391687920606979	22:37010858-37020183:-	TST	13;GO:0003723,molecular_function RNA binding;GO:0004792,molecular_function thiosulfate sulfurtransferase activity;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0008097,molecular_function 5S rRNA binding;GO:0009440,biological_process cyanate catabolic process;GO:0016740,molecular_function transferase activity;GO:0030855,biological_process epithelial cell differentiation;GO:0035928,biological_process rRNA import into mitochondrion;GO:0051029,biological_process rRNA transport;GO:0070062,cellular_component extracellular exosome	TST, MPST, sseA; thiosulfate/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]; K01011	thiosulfate sulfurtransferase [Source:HGNC Symbol%3BAcc:HGNC:12388]
ENSG00000169946	3.70	3.27	3.84	2.99	3.27	3.28	0.198339600964676	3.5713902271624	0.0853628851996295	0.391722548607394	8:104590732-105804532:+	ZFPM2	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001570,biological_process vasculogenesis;GO:0001701,biological_process in utero embryonic development;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003221,biological_process right ventricular cardiac muscle tissue morphogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007506,biological_process gonadal mesoderm development;GO:0007507,biological_process heart development;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048568,biological_process embryonic organ development;GO:0048738,biological_process cardiac muscle tissue development;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060548,biological_process negative regulation of cell death;GO:2000020,biological_process positive regulation of male gonad development;GO:2000195,biological_process negative regulation of female gonad development	ZFPM2, FOG2; zinc finger protein ZFPM2; K17442	zinc finger protein%2C FOG family member 2 [Source:HGNC Symbol%3BAcc:HGNC:16700]
ENSG00000116747	16.60	17.30	16.45	15.99	13.69	16.08	0.146283761707351	4.79371113999138	0.0855651979310173	0.392364647475614	1:193059421-193091777:+	TROVE2	14;GO:0002520,biological_process immune system development;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0007224,biological_process smoothened signaling pathway;GO:0009411,biological_process response to UV;GO:0030030,biological_process cell projection organization;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030620,molecular_function U2 snRNA binding;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis	TROVE2, SSA2; 60 kDa SS-A/Ro ribonucleoprotein; K11089	TROVE domain family member 2 [Source:HGNC Symbol%3BAcc:HGNC:11313]
ENSG00000234409	0.12	0.40	1.04	0.87	0.82	1.05	-0.791873246400368	0.0365137094681436	0.0855660276094809	0.392364647475614	22:20148426-20151065:-	CCDC188	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	coiled-coil domain containing 188 [Source:HGNC Symbol%3BAcc:HGNC:51899]
ENSG00000162910	34.81	29.46	37.77	29.46	25.38	33.95	0.217514795962872	3.99033187948577	0.0856373362432272	0.392546622890391	1:228106678-228109312:-	MRPL55	9;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L55 [Source:HGNC Symbol%3BAcc:HGNC:16686]
ENSG00000181192	9.98	10.97	9.88	11.85	10.91	11.40	-0.141537308796177	4.92329354225019	0.0856765469254834	0.392581386853461	10:12068971-12123225:+	DHTKD1	14;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0004591,molecular_function oxoglutarate dehydrogenase (succinyl-transferring) activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006096,biological_process glycolytic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016624,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;GO:0030976,molecular_function thiamine pyrophosphate binding;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0045252,cellular_component oxoglutarate dehydrogenase complex;GO:0055114,biological_process oxidation-reduction process	DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]; K15791	dehydrogenase E1 and transketolase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23537]
ENSG00000057935	21.68	21.54	22.83	23.54	23.20	25.88	-0.12496638504984	5.46313439473313	0.0857380782221968	0.39271836345835	2:42494568-42756947:+	MTA3	18;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016575,biological_process histone deacetylation;GO:0032403,molecular_function protein complex binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	metastasis associated 1 family member 3 [Source:HGNC Symbol%3BAcc:HGNC:23784]
ENSG00000264522	11.37	10.77	11.32	11.93	12.75	12.32	-0.130255450462998	4.90221712992257	0.0859078028716617	0.393350629673898	1:149937811-150010676:-	OTUD7B	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002385,biological_process mucosal immune response;GO:0003677,molecular_function DNA binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006955,biological_process immune response;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0032717,biological_process negative regulation of interleukin-8 production;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0071947,biological_process protein deubiquitination involved in ubiquitin-dependent protein catabolic process;GO:1900181,biological_process negative regulation of protein localization to nucleus;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	NA	OTU deubiquitinase 7B [Source:HGNC Symbol%3BAcc:HGNC:16683]
ENSG00000198925	25.96	24.81	26.47	23.81	23.36	24.98	0.111453104080022	5.97571738774294	0.0859961082522175	0.393589804138793	2:219209771-219229717:-	ATG9A	24;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031667,biological_process response to nutrient levels;GO:0031902,cellular_component late endosome membrane;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044805,biological_process late nucleophagy;GO:0055037,cellular_component recycling endosome	NA	autophagy related 9A [Source:HGNC Symbol%3BAcc:HGNC:22408]
ENSG00000121486	13.78	14.66	13.83	14.23	17.07	15.76	-0.146008604364882	5.04337043620532	0.0860234543324374	0.393589804138793	1:185118097-185157072:-	TRMT1L	11;GO:0000049,molecular_function tRNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004809,molecular_function tRNA (guanine-N2-)-methyltransferase activity;GO:0007610,biological_process behavior;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	tRNA methyltransferase 1 like [Source:HGNC Symbol%3BAcc:HGNC:16782]
ENSG00000124831	63.67	61.64	65.20	66.05	68.52	72.22	-0.10608702604195	7.86708984747774	0.0860646158802099	0.39363304234379	2:237627575-237813682:+	LRRFIP1	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008150,biological_process biological_process;GO:0032481,biological_process positive regulation of type I interferon production;GO:0042803,molecular_function protein homodimerization activity;GO:0045296,molecular_function cadherin binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	NA	LRR binding FLII interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6702]
ENSG00000010292	46.45	53.59	46.58	52.71	56.82	51.78	-0.127190123398276	7.75428954471469	0.0861250382668115	0.3937195117633	12:6493355-6531955:+	NCAPD2	22;GO:0000228,cellular_component nuclear chromosome;GO:0000278,biological_process mitotic cell cycle;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000793,cellular_component condensed chromosome;GO:0000796,cellular_component condensin complex;GO:0000797,cellular_component condensin core heterodimer;GO:0000799,cellular_component nuclear condensin complex;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0010032,biological_process meiotic chromosome condensation;GO:0016020,cellular_component membrane;GO:0030261,biological_process chromosome condensation;GO:0042393,molecular_function histone binding;GO:0051301,biological_process cell division;GO:0051304,biological_process chromosome separation	NA	non-SMC condensin I complex subunit D2 [Source:HGNC Symbol%3BAcc:HGNC:24305]
ENSG00000116514	15.62	12.25	16.22	17.88	14.96	17.52	-0.173954719214711	5.1368727457167	0.0861469583460182	0.3937195117633	1:32936444-32964685:-	RNF19B	17;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0044194,cellular_component cytolytic granule;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 19B [Source:HGNC Symbol%3BAcc:HGNC:26886]
ENSG00000137177	19.81	20.94	19.54	21.05	22.77	21.85	-0.112547832113775	6.8865410057245	0.0862730210095158	0.3941505372805	6:17759182-17987623:-	KIF13A	35;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005623,cellular_component cell;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008333,biological_process endosome to lysosome transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0030496,cellular_component midbody;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0032438,biological_process melanosome organization;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035459,biological_process cargo loading into vesicle;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0051301,biological_process cell division;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule	NA	kinesin family member 13A [Source:HGNC Symbol%3BAcc:HGNC:14566]
ENSG00000130429	8.14	6.54	6.95	6.75	6.24	5.36	0.259921354433374	2.97327116495821	0.0863573139462323	0.394390484920744	7:99374248-99394801:+	ARPC1B	19;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0015629,cellular_component actin cytoskeleton;GO:0030833,biological_process regulation of actin filament polymerization;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0036284,cellular_component tubulobulbar complex;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043627,biological_process response to estrogen;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B; K05757	actin related protein 2/3 complex subunit 1B [Source:HGNC Symbol%3BAcc:HGNC:704]
ENSG00000174109	14.45	16.17	13.20	18.72	14.36	20.78	-0.297400565200065	2.72446495862835	0.0864149683001317	0.394508643438593	16:1419743-1420800:-	C16orf91	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 16 open reading frame 91 [Source:HGNC Symbol%3BAcc:HGNC:27558]
ENSG00000145242	0.34	0.34	0.43	0.12	0.34	0.23	0.697220948198116	0.106897771262437	0.0865658258165397	0.395052057301731	4:65319562-65670495:-	EPHA5	39;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005003,molecular_function ephrin receptor activity;GO:0005004,molecular_function GPI-linked ephrin receptor activity;GO:0005005,molecular_function transmembrane-ephrin receptor activity;GO:0005524,molecular_function ATP binding;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005912,cellular_component adherens junction;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019933,biological_process cAMP-mediated signaling;GO:0021766,biological_process hippocampus development;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043087,biological_process regulation of GTPase activity;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048666,biological_process neuron development;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0071944,cellular_component cell periphery;GO:1904322,biological_process cellular response to forskolin	EPHA5, EHK1, TYRO4; Eph receptor A5 [EC:2.7.10.1]; K05106	EPH receptor A5 [Source:HGNC Symbol%3BAcc:HGNC:3389]
ENSG00000123405	1.26	0.60	1.32	2.14	0.95	1.76	-0.559305427223376	0.750784644403991	0.0866500731241351	0.395172384548393	12:54292110-54301121:-	NFE2	23;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006337,biological_process nucleosome disassembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0008015,biological_process blood circulation;GO:0016605,cellular_component PML body;GO:0032993,cellular_component protein-DNA complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0050699,molecular_function WW domain binding	NA	nuclear factor%2C erythroid 2 [Source:HGNC Symbol%3BAcc:HGNC:7780]
ENSG00000153975	11.04	9.81	9.89	11.62	10.45	13.02	-0.177303644043954	4.26642895930149	0.0866558632676006	0.395172384548393	6:116635617-116668794:-	ZUFSP	3;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger with UFM1 specific peptidase domain [Source:HGNC Symbol%3BAcc:HGNC:21224]
ENSG00000106771	22.49	24.16	22.91	24.61	26.19	25.00	-0.114466135162441	6.00186357907449	0.0867190216618277	0.395315172929955	9:109015151-109119945:-	TMEM245	4;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 245 [Source:HGNC Symbol%3BAcc:HGNC:1363]
ENSG00000186635	14.04	13.75	13.94	12.88	12.79	13.41	0.107064946954213	5.97681356608763	0.0867966460038736	0.395523776375214	11:72685068-72793599:-	ARAP1	25;GO:0001921,biological_process positive regulation of receptor recycling;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0030037,biological_process actin filament reorganization involved in cell cycle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0032580,cellular_component Golgi cisterna membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051270,biological_process regulation of cellular component movement;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051497,biological_process negative regulation of stress fiber assembly	ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; K12490	ArfGAP with RhoGAP domain%2C ankyrin repeat and PH domain 1 [Source:HGNC Symbol%3BAcc:HGNC:16925]
ENSG00000044446	12.60	12.10	13.43	11.66	11.71	12.03	0.121128298972611	5.51097301928223	0.0868536957632622	0.395638504774082	X:18892299-18984598:-	PHKA2	14;GO:0003824,molecular_function catalytic activity;GO:0004689,molecular_function phosphorylase kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005964,cellular_component phosphorylase kinase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005980,biological_process glycogen catabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane	PHKA_B; phosphorylase kinase alpha/beta subunit; K07190	phosphorylase kinase regulatory subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:8926]
ENSG00000154065	11.57	12.83	11.73	10.05	10.80	11.08	0.182677415574329	3.67672295090566	0.0870018128241957	0.396131812886839	18:23598925-23662885:-	ANKRD29	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ankyrin repeat domain 29 [Source:HGNC Symbol%3BAcc:HGNC:27110]
ENSG00000049249	6.41	2.59	5.90	7.67	5.00	8.03	-0.442719600970025	2.40580528504579	0.0870258159786038	0.396131812886839	1:7915893-7943165:-	TNFRSF9	22;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007275,biological_process multicellular organism development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019955,molecular_function cytokine binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0070207,biological_process protein homotrimerization;GO:0097190,biological_process apoptotic signaling pathway;GO:2001180,biological_process negative regulation of interleukin-10 secretion;GO:2001183,biological_process negative regulation of interleukin-12 secretion	TNFRSF9, CD137; tumor necrosis factor receptor superfamily member 9; K05146	TNF receptor superfamily member 9 [Source:HGNC Symbol%3BAcc:HGNC:11924]
ENSG00000225663	37.78	38.59	39.99	35.77	36.40	32.71	0.162917267393622	4.13565489978578	0.0870657590298194	0.396166920092735	17:81822360-81833302:-	MCRIP1	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010717,biological_process regulation of epithelial to mesenchymal transition	NA	MAPK regulated corepressor interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:28007]
ENSG00000134317	0.63	0.40	0.50	0.94	1.03	0.44	-0.609001646036381	0.504213053943286	0.0870973596175842	0.396166920092735	2:9951692-10002277:+	GRHL1	21;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002934,biological_process desmosome organization;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008544,biological_process epidermis development;GO:0019216,biological_process regulation of lipid metabolic process;GO:0031490,molecular_function chromatin DNA binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0061436,biological_process establishment of skin barrier	NA	grainyhead like transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:17923]
ENSG00000157240	14.05	18.71	14.94	14.54	13.60	14.27	0.172464642063337	4.86670821420422	0.0872481553225193	0.396663015197128	7:91264363-91271326:+	FZD1	46;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003149,biological_process membranous septum morphogenesis;GO:0003150,biological_process muscular septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0030165,molecular_function PDZ domain binding;GO:0030182,biological_process neuron differentiation;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030855,biological_process epithelial cell differentiation;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0035425,biological_process autocrine signaling;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0042493,biological_process response to drug;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0044338,biological_process canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation;GO:0044339,biological_process canonical Wnt signaling pathway involved in osteoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060022,biological_process hard palate development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060412,biological_process ventricular septum morphogenesis;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:0099054,biological_process presynapse assembly;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:1904953,biological_process Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;GO:1990909,cellular_component Wnt signalosome	FZD1_7, fz; frizzled 1/7; K02432	frizzled class receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:4038]
ENSG00000204264	134.06	127.32	134.82	148.73	132.15	153.27	-0.119613149372602	7.06143337554929	0.0872703371065299	0.396663015197128	6:32840716-32844703:-	PSMB8	47;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0019882,biological_process antigen processing and presentation;GO:0030154,biological_process cell differentiation;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045444,biological_process fat cell differentiation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0052548,biological_process regulation of endopeptidase activity;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1990111,cellular_component spermatoproteasome complex	PSMB8, LMP7; 20S proteasome subunit beta 8 [EC:3.4.25.1]; K02740	proteasome subunit beta 8 [Source:HGNC Symbol%3BAcc:HGNC:9545]
ENSG00000144468	16.31	16.21	14.31	14.23	12.06	15.11	0.185431776760689	4.06137645870649	0.0873213223919079	0.39674947834947	2:226835580-226999215:+	RHBDD1	24;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0007283,biological_process spermatogenesis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0010954,biological_process positive regulation of protein processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0034620,biological_process cellular response to unfolded protein;GO:0034644,biological_process cellular response to UV;GO:0036503,biological_process ERAD pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0048515,biological_process spermatid differentiation;GO:1904211,biological_process membrane protein proteolysis involved in retrograde protein transport, ER to cytosol	NA	rhomboid domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23081]
ENSG00000090487	69.02	64.81	66.05	62.34	63.39	61.13	0.110867845098755	5.90401636704844	0.0873534900112318	0.396750410358368	15:64963020-64990310:-	SPG21	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0042609,molecular_function CD4 receptor binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050851,biological_process antigen receptor-mediated signaling pathway	NA	SPG21%2C maspardin [Source:HGNC Symbol%3BAcc:HGNC:20373]
ENSG00000131094	71.54	67.04	62.86	72.94	74.37	73.23	-0.1183440565227	5.77203917814421	0.0873897416944101	0.396769884291409	17:44959692-44968071:-	C1QL1	14;GO:0003674,molecular_function molecular_function;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0005581,cellular_component collagen trimer;GO:0005737,cellular_component cytoplasm;GO:0007626,biological_process locomotory behavior;GO:0016322,biological_process neuron remodeling;GO:0043083,cellular_component synaptic cleft;GO:0044301,cellular_component climbing fiber;GO:0061743,biological_process motor learning;GO:0098793,cellular_component presynapse;GO:0099558,biological_process maintenance of synapse structure	NA	complement C1q like 1 [Source:HGNC Symbol%3BAcc:HGNC:24182]
ENSG00000006788	4.51	4.41	4.34	4.20	3.91	4.03	0.138779019923001	4.62975275147096	0.0874766117788341	0.397019079345765	17:10300864-10373130:-	MYH13	13;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005859,cellular_component muscle myosin complex;GO:0006936,biological_process muscle contraction;GO:0016459,cellular_component myosin complex;GO:0030016,cellular_component myofibril;GO:0032982,cellular_component myosin filament;GO:0070062,cellular_component extracellular exosome	MYH; myosin heavy chain; K10352	myosin heavy chain 13 [Source:HGNC Symbol%3BAcc:HGNC:7571]
ENSG00000175806	5.23	5.73	4.25	3.83	4.13	4.29	0.309651534585651	2.11241560211972	0.0875429396066764	0.39708792899668	8:10054267-10428891:+	MSRA	15;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006555,biological_process methionine metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0008113,molecular_function peptide-methionine (S)-S-oxide reductase activity;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030091,biological_process protein repair;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	methionine sulfoxide reductase A [Source:HGNC Symbol%3BAcc:HGNC:7377]
ENSG00000276293	37.63	37.29	38.22	41.16	42.05	40.17	-0.112282498005883	5.62648058124576	0.0875557610298811	0.39708792899668	17:38765688-38800126:-	PIP4K2B	29;GO:0000166,molecular_function nucleotide binding;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006644,biological_process phospholipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0010506,biological_process regulation of autophagy;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016307,molecular_function phosphatidylinositol phosphate kinase activity;GO:0016308,molecular_function 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0016309,molecular_function 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0052811,molecular_function 1-phosphatidylinositol-3-phosphate 4-kinase activity;GO:2000786,biological_process positive regulation of autophagosome assembly	PIP4K2; 1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]; K00920	phosphatidylinositol-5-phosphate 4-kinase type 2 beta [Source:HGNC Symbol%3BAcc:HGNC:8998]
ENSG00000147853	40.34	44.77	41.29	37.82	36.08	41.10	0.141951817836885	4.78210454394751	0.0877043411517001	0.397573935181421	9:4709558-4742043:-	AK3	18;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0007596,biological_process blood coagulation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016776,molecular_function phosphotransferase activity, phosphate group as acceptor;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0046033,biological_process AMP metabolic process;GO:0046039,biological_process GTP metabolic process;GO:0046041,biological_process ITP metabolic process;GO:0046051,biological_process UTP metabolic process;GO:0046899,molecular_function nucleoside triphosphate adenylate kinase activity	AK3; nucleoside-triphosphate--adenylate kinase [EC:2.7.4.10]; K00944	adenylate kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:17376]
ENSG00000221947	6.53	4.85	5.06	5.94	6.45	7.65	-0.265955616615367	2.93472426861818	0.0877269804609613	0.397573935181421	8:70669364-70790371:+	XKR9	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	XK related 9 [Source:HGNC Symbol%3BAcc:HGNC:20937]
ENSG00000158711	7.57	6.42	7.27	8.28	7.38	9.31	-0.214683760626203	3.48827397072611	0.0878614589921961	0.397790583138707	1:205597555-205631962:-	ELK4	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070932,biological_process histone H3 deacetylation	ELK4, SAP1; ETS domain-containing protein Elk-4; K04376	ELK4%2C ETS transcription factor [Source:HGNC Symbol%3BAcc:HGNC:3326]
ENSG00000149554	19.07	20.35	17.10	22.51	21.91	18.99	-0.156967726529527	5.0922101730508	0.0878638192169356	0.397790583138707	11:125625135-125676255:+	CHEK1	53;GO:0000077,biological_process DNA damage checkpoint;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000781,cellular_component chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0000794,cellular_component condensed nuclear chromosome;GO:0001833,biological_process inner cell mass cell proliferation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0006997,biological_process nucleus organization;GO:0007049,biological_process cell cycle;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0010468,biological_process regulation of gene expression;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0010767,biological_process regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019904,molecular_function protein domain specific binding;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0035402,molecular_function histone kinase activity (H3-T11 specific);GO:0035407,biological_process histone H3-T11 phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0042127,biological_process regulation of cell proliferation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045787,biological_process positive regulation of cell cycle;GO:0045839,biological_process negative regulation of mitotic nuclear division;GO:0046602,biological_process regulation of mitotic centrosome separation;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0090399,biological_process replicative senescence;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902742,biological_process apoptotic process involved in development;GO:2000615,biological_process regulation of histone H3-K9 acetylation	CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]; K02216	checkpoint kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:1925]
ENSG00000155090	51.78	45.90	52.94	58.22	52.30	55.21	-0.123095802290023	6.25502922626884	0.0878859620229581	0.397790583138707	8:102648778-102655902:-	KLF10	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007623,biological_process circadian rhythm;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009267,biological_process cellular response to starvation;GO:0030282,biological_process bone mineralization;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042752,biological_process regulation of circadian rhythm;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:1901653,biological_process cellular response to peptide	NA	Kruppel like factor 10 [Source:HGNC Symbol%3BAcc:HGNC:11810]
ENSG00000100055	0.92	1.31	1.12	1.48	2.43	1.07	-0.568789412181058	0.974052611998612	0.087936963028656	0.397790583138707	22:37282026-37315345:+	CYTH4	9;GO:0000139,cellular_component Golgi membrane;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	cytohesin 4 [Source:HGNC Symbol%3BAcc:HGNC:9505]
ENSG00000144674	29.36	30.61	32.23	28.12	29.70	28.38	0.108776893896112	7.67995507131566	0.0879380173217901	0.397790583138707	3:37243176-37366751:+	GOLGA4	14;GO:0000042,biological_process protein targeting to Golgi;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045773,biological_process positive regulation of axon extension;GO:0051020,molecular_function GTPase binding;GO:0070062,cellular_component extracellular exosome	NA	golgin A4 [Source:HGNC Symbol%3BAcc:HGNC:4427]
ENSG00000177453	3.35	2.41	3.15	2.18	1.68	3.01	0.394474053679401	1.85564179585463	0.0879670628144487	0.397790583138707	5:43192070-43280850:+	NIM1K	13;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	NIM1 serine/threonine protein kinase [Source:HGNC Symbol%3BAcc:HGNC:28646]
ENSG00000120942	10.57	10.99	9.51	11.61	11.83	12.16	-0.190183713343592	3.65849971201224	0.0880322386869846	0.39786206673899	1:11273205-11296049:+	UBIAD1	22;GO:0000139,cellular_component Golgi membrane;GO:0004659,molecular_function prenyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0009234,biological_process menaquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016209,molecular_function antioxidant activity;GO:0016740,molecular_function transferase activity;GO:0016765,molecular_function transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0030173,cellular_component integral component of Golgi membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032194,biological_process ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate;GO:0042371,biological_process vitamin K biosynthetic process;GO:0042373,biological_process vitamin K metabolic process;GO:0098869,biological_process cellular oxidant detoxification	NA	UbiA prenyltransferase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30791]
ENSG00000214194	217.06	234.32	261.55	203.89	233.95	211.35	0.147331309170686	5.33382596840388	0.0880492368348366	0.39786206673899	7:113116717-113118613:-	SMIM30	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 30 [Source:HGNC Symbol%3BAcc:HGNC:48953]
ENSG00000132692	1.82	1.96	2.18	2.19	2.38	2.61	-0.259334882521736	2.67344651096627	0.0881238021157172	0.39786206673899	1:156641389-156659532:+	BCAN	19;GO:0001501,biological_process skeletal system development;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005540,molecular_function hyaluronic acid binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005796,cellular_component Golgi lumen;GO:0007155,biological_process cell adhesion;GO:0007417,biological_process central nervous system development;GO:0016020,cellular_component membrane;GO:0021766,biological_process hippocampus development;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0030246,molecular_function carbohydrate binding;GO:0031225,cellular_component anchored component of membrane;GO:0043202,cellular_component lysosomal lumen	NA	brevican [Source:HGNC Symbol%3BAcc:HGNC:23059]
ENSG00000044574	521.20	515.14	505.42	489.19	467.62	496.24	0.0972827776791256	9.93690972001505	0.08816502987864	0.39786206673899	9:125234852-125241330:-	HSPA5	74;GO:0000166,molecular_function nucleotide binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006983,biological_process ER overload response;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0008180,cellular_component COP9 signalosome;GO:0009314,biological_process response to radiation;GO:0009986,cellular_component cell surface;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0021589,biological_process cerebellum structural organization;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0021762,biological_process substantia nigra development;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030182,biological_process neuron differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030496,cellular_component midbody;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031012,cellular_component extracellular matrix;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035437,biological_process maintenance of protein localization in endoplasmic reticulum;GO:0035690,biological_process cellular response to drug;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0042149,biological_process cellular response to glucose starvation;GO:0042220,biological_process response to cocaine;GO:0042470,cellular_component melanosome;GO:0043022,molecular_function ribosome binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0045296,molecular_function cadherin binding;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051402,biological_process neuron apoptotic process;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0051787,molecular_function misfolded protein binding;GO:0060904,biological_process regulation of protein folding in endoplasmic reticulum;GO:0070062,cellular_component extracellular exosome;GO:0071236,biological_process cellular response to antibiotic;GO:0071277,biological_process cellular response to calcium ion;GO:0071287,biological_process cellular response to manganese ion;GO:0071320,biological_process cellular response to cAMP;GO:0071353,biological_process cellular response to interleukin-4;GO:0090074,biological_process negative regulation of protein homodimerization activity;GO:0097501,biological_process stress response to metal ion;GO:1901998,biological_process toxin transport;GO:1903891,biological_process regulation of ATF6-mediated unfolded protein response;GO:1903894,biological_process regulation of IRE1-mediated unfolded protein response;GO:1903897,biological_process regulation of PERK-mediated unfolded protein response;GO:1904313,biological_process response to methamphetamine hydrochloride;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	HSPA5, BIP; heat shock 70kDa protein 5; K09490	heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol%3BAcc:HGNC:5238]
ENSG00000167193	45.17	49.80	46.02	49.60	52.87	51.46	-0.11829178553818	5.8643903265514	0.0881685518126985	0.39786206673899	17:1420688-1463162:-	CRK	52;GO:0000186,biological_process activation of MAPKK activity;GO:0001784,molecular_function phosphotyrosine binding;GO:0001878,biological_process response to yeast;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008360,biological_process regulation of cell shape;GO:0009966,biological_process regulation of signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030674,molecular_function protein binding, bridging;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035020,biological_process regulation of Rac protein signal transduction;GO:0035728,biological_process response to hepatocyte growth factor;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042169,molecular_function SH2 domain binding;GO:0042542,biological_process response to hydrogen peroxide;GO:0043087,biological_process regulation of GTPase activity;GO:0043234,cellular_component protein complex;GO:0043393,biological_process regulation of protein binding;GO:0043621,molecular_function protein self-association;GO:0045121,cellular_component membrane raft;GO:0045309,molecular_function protein phosphorylated amino acid binding;GO:0045953,biological_process negative regulation of natural killer cell mediated cytotoxicity;GO:0046875,molecular_function ephrin receptor binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0061045,biological_process negative regulation of wound healing;GO:0061847,biological_process response to cholecystokinin;GO:0070062,cellular_component extracellular exosome;GO:0071538,biological_process SH2 domain-mediated complex assembly;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071732,biological_process cellular response to nitric oxide;GO:0097110,molecular_function scaffold protein binding;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1901652,biological_process response to peptide;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990314,biological_process cellular response to insulin-like growth factor stimulus;GO:1990782,molecular_function protein tyrosine kinase binding;GO:1990859,biological_process cellular response to endothelin;GO:2000146,biological_process negative regulation of cell motility	CRK, CRKII; proto-oncogene C-crk; K04438	CRK proto-oncogene%2C adaptor protein [Source:HGNC Symbol%3BAcc:HGNC:2362]
ENSG00000270647	120.54	109.22	114.00	124.63	122.66	125.42	-0.104191283881576	7.99611140423298	0.0881751829210474	0.39786206673899	17:35713790-35864615:+	TAF15	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	TAF15, NPL3; transcription initiation factor TFIID subunit 15; K14651	TATA-box binding protein associated factor 15 [Source:HGNC Symbol%3BAcc:HGNC:11547]
ENSG00000164761	20.94	22.08	17.00	21.77	22.97	23.06	-0.169950285107569	4.72881654320872	0.0882900558201275	0.398235633319492	8:118923556-118952200:-	TNFRSF11B	27;GO:0001501,biological_process skeletal system development;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007584,biological_process response to nutrient;GO:0010035,biological_process response to inorganic substance;GO:0030198,biological_process extracellular matrix organization;GO:0032026,biological_process response to magnesium ion;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042489,biological_process negative regulation of odontogenesis of dentin-containing tooth;GO:0042493,biological_process response to drug;GO:0042981,biological_process regulation of apoptotic process;GO:0043627,biological_process response to estrogen;GO:0045779,biological_process negative regulation of bone resorption;GO:0046685,biological_process response to arsenic-containing substance;GO:0097190,biological_process apoptotic signaling pathway	TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B; K05148	TNF receptor superfamily member 11b [Source:HGNC Symbol%3BAcc:HGNC:11909]
ENSG00000121068	1.45	1.57	1.69	1.02	0.89	1.65	0.408585521289085	1.62798480777004	0.0883274999721967	0.398252066212138	17:61399895-61409466:+	TBX2	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001947,biological_process heart looping;GO:0003007,biological_process heart morphogenesis;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003256,biological_process regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007521,biological_process muscle cell fate determination;GO:0007569,biological_process cell aging;GO:0008016,biological_process regulation of heart contraction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0035050,biological_process embryonic heart tube development;GO:0035909,biological_process aorta morphogenesis;GO:0036302,biological_process atrioventricular canal development;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0048738,biological_process cardiac muscle tissue development;GO:0060021,biological_process palate development;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060465,biological_process pharynx development;GO:0060560,biological_process developmental growth involved in morphogenesis;GO:0060596,biological_process mammary placode formation;GO:0090398,biological_process cellular senescence;GO:1901208,biological_process negative regulation of heart looping;GO:1901211,biological_process negative regulation of cardiac chamber formation	TBX2; T-box protein 2; K10176	T-box 2 [Source:HGNC Symbol%3BAcc:HGNC:11597]
ENSG00000013374	50.93	47.70	49.63	60.02	48.31	55.76	-0.134140511610566	6.8418033093024	0.0883578659750447	0.398252066212138	7:151341698-151378449:+	NUB1	3;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol	NA	negative regulator of ubiquitin like proteins 1 [Source:HGNC Symbol%3BAcc:HGNC:17623]
ENSG00000152642	3.89	2.54	3.15	4.20	3.60	4.54	-0.333939640705149	2.01665206817381	0.08846622833104	0.398315910665394	3:32105688-32168713:+	GPD1L	28;GO:0002027,biological_process regulation of heart rate;GO:0004367,molecular_function glycerol-3-phosphate dehydrogenase [NAD+] activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006072,biological_process glycerol-3-phosphate metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006734,biological_process NADH metabolic process;GO:0009331,cellular_component glycerol-3-phosphate dehydrogenase complex;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0017080,molecular_function sodium channel regulator activity;GO:0019674,biological_process NAD metabolic process;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0044325,molecular_function ion channel binding;GO:0046168,biological_process glycerol-3-phosphate catabolic process;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0060373,biological_process regulation of ventricular cardiac muscle cell membrane depolarization;GO:0070062,cellular_component extracellular exosome;GO:0086005,biological_process ventricular cardiac muscle cell action potential;GO:0090038,biological_process negative regulation of protein kinase C signaling;GO:2000010,biological_process positive regulation of protein localization to cell surface;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]; K00006	glycerol-3-phosphate dehydrogenase 1 like [Source:HGNC Symbol%3BAcc:HGNC:28956]
ENSG00000008405	6.23	6.41	6.28	7.50	6.90	7.28	-0.186708599751636	3.5929194724344	0.0884681004655651	0.398315910665394	12:106991363-107093829:-	CRY1	43;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006094,biological_process gluconeogenesis;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0009785,biological_process blue light signaling pathway;GO:0009881,molecular_function photoreceptor activity;GO:0009882,molecular_function blue light photoreceptor activity;GO:0016829,molecular_function lyase activity;GO:0018298,biological_process protein-chromophore linkage;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0019915,biological_process lipid storage;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032868,biological_process response to insulin;GO:0032922,biological_process circadian regulation of gene expression;GO:0033762,biological_process response to glucagon;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0042593,biological_process glucose homeostasis;GO:0042752,biological_process regulation of circadian rhythm;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0042826,molecular_function histone deacetylase binding;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0050896,biological_process response to stimulus;GO:2000001,biological_process regulation of DNA damage checkpoint;GO:2000323,biological_process negative regulation of glucocorticoid receptor signaling pathway;GO:2000850,biological_process negative regulation of glucocorticoid secretion	NA	cryptochrome circadian clock 1 [Source:HGNC Symbol%3BAcc:HGNC:2384]
ENSG00000024048	10.78	9.91	9.88	10.83	11.15	11.38	-0.112695503626486	5.85230165083585	0.0884682966007003	0.398315910665394	6:42564061-42693504:+	UBR2	23;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0000785,cellular_component chromatin;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006342,biological_process chromatin silencing;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007141,biological_process male meiosis I;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030163,biological_process protein catabolic process;GO:0032007,biological_process negative regulation of TOR signaling;GO:0033522,biological_process histone H2A ubiquitination;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070728,molecular_function leucine binding;GO:0071233,biological_process cellular response to leucine;GO:0071596,biological_process ubiquitin-dependent protein catabolic process via the N-end rule pathway	NA	ubiquitin protein ligase E3 component n-recognin 2 [Source:HGNC Symbol%3BAcc:HGNC:21289]
ENSG00000198886	7784.52	8412.68	8143.87	7588.37	7975.62	7189.49	0.109022963054591	13.4022244340325	0.0885141532109326	0.398377876652395	MT:10759-12137:+	MT-ND4	19;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0007568,biological_process aging;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0021549,biological_process cerebellum development;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035094,biological_process response to nicotine;GO:0042773,biological_process ATP synthesis coupled electron transport;GO:0045471,biological_process response to ethanol;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]; K03881	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:7459]
ENSG00000116584	62.26	48.69	65.80	74.34	55.90	74.16	-0.19710940990812	7.68177793586318	0.0885618697008514	0.398383321746814	1:155946850-156007070:-	ARHGEF2	59;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000902,biological_process cell morphogenesis;GO:0002102,cellular_component podosome;GO:0002376,biological_process immune system process;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0005925,cellular_component focal adhesion;GO:0006886,biological_process intracellular protein transport;GO:0007015,biological_process actin filament organization;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0017048,molecular_function Rho GTPase binding;GO:0030054,cellular_component cell junction;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0032587,cellular_component ruffle membrane;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042127,biological_process regulation of cell proliferation;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043198,cellular_component dendritic shaft;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048365,molecular_function Rac GTPase binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050768,biological_process negative regulation of neurogenesis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051301,biological_process cell division;GO:0060546,biological_process negative regulation of necroptotic process;GO:0071225,biological_process cellular response to muramyl dipeptide;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071474,biological_process cellular hyperosmotic response;GO:0071802,biological_process negative regulation of podosome assembly;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902219,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2; K12791	Rho/Rac guanine nucleotide exchange factor 2 [Source:HGNC Symbol%3BAcc:HGNC:682]
ENSG00000065135	124.76	132.28	130.99	140.93	133.26	148.45	-0.112317660610355	7.16720498944561	0.0885975117282804	0.398383321746814	1:109548610-109618321:+	GNAI3	40;GO:0000166,molecular_function nucleotide binding;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006810,biological_process transport;GO:0006906,biological_process vesicle fusion;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007194,biological_process negative regulation of adenylate cyclase activity;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0019003,molecular_function GDP binding;GO:0019904,molecular_function protein domain specific binding;GO:0030496,cellular_component midbody;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031821,molecular_function G-protein coupled serotonin receptor binding;GO:0032794,molecular_function GTPase activating protein binding;GO:0042588,cellular_component zymogen granule;GO:0045121,cellular_component membrane raft;GO:0046039,biological_process GTP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome	GNAI; guanine nucleotide-binding protein G(i) subunit alpha; K04630	G protein subunit alpha i3 [Source:HGNC Symbol%3BAcc:HGNC:4387]
ENSG00000105339	21.61	21.77	22.42	23.94	23.48	24.01	-0.106467109985666	6.64854940007998	0.0886116451577342	0.398383321746814	8:141117277-141195808:+	DENND3	7;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005829,cellular_component cytosol;GO:0008333,biological_process endosome to lysosome transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044257,biological_process cellular protein catabolic process;GO:0061024,biological_process membrane organization	NA	DENN domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:29134]
ENSG00000161921	1.21	1.87	2.16	1.83	3.06	2.58	-0.508958786175655	0.916306865548784	0.0887165007626326	0.398562331870557	17:4733525-4739922:-	CXCL16	20;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006935,biological_process chemotaxis;GO:0008009,molecular_function chemokine activity;GO:0010818,biological_process T cell chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0034097,biological_process response to cytokine;GO:0034341,biological_process response to interferon-gamma;GO:0034612,biological_process response to tumor necrosis factor;GO:0042379,molecular_function chemokine receptor binding;GO:0048247,biological_process lymphocyte chemotaxis;GO:0071222,biological_process cellular response to lipopolysaccharide	CXCL16; C-X-C motif chemokine 16; K10035	C-X-C motif chemokine ligand 16 [Source:HGNC Symbol%3BAcc:HGNC:16642]
ENSG00000146007	126.55	117.03	106.30	126.91	127.56	129.57	-0.12254271688038	6.2257589122734	0.0887272156203681	0.398562331870557	5:140698679-140706676:+	ZMAT2	9;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0008270,molecular_function zinc ion binding;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0046872,molecular_function metal ion binding	SNU23; U4/U6.U5 tri-snRNP component SNU23; K12848	zinc finger matrin-type 2 [Source:HGNC Symbol%3BAcc:HGNC:26433]
ENSG00000161671	43.64	47.67	44.00	39.84	42.64	43.13	0.115745730755736	5.81634462630318	0.0887477874236864	0.398562331870557	19:50476399-50490870:+	EMC10	4;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 10 [Source:HGNC Symbol%3BAcc:HGNC:27609]
ENSG00000091640	51.37	51.61	47.74	56.69	51.05	58.42	-0.131220420497359	5.35996401450862	0.0888452785683214	0.398855856371997	17:4959225-4967872:-	SPAG7	2;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus	NA	sperm associated antigen 7 [Source:HGNC Symbol%3BAcc:HGNC:11216]
ENSG00000120699	28.15	27.24	26.31	33.28	26.93	31.93	-0.162365658609953	4.59619429515797	0.0889342653852929	0.399014095503354	13:36998815-37009613:+	EXOSC8	27;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000467,biological_process exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0006401,biological_process RNA catabolic process;GO:0008150,biological_process biological_process;GO:0017091,molecular_function AU-rich element binding;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034473,biological_process U1 snRNA 3'-end processing;GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0034476,biological_process U5 snRNA 3'-end processing;GO:0042802,molecular_function identical protein binding;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071035,biological_process nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038,biological_process nuclear polyadenylation-dependent tRNA catabolic process;GO:0071042,biological_process nuclear polyadenylation-dependent mRNA catabolic process	RRP43, EXOSC8, OIP2; exosome complex component RRP43; K12586	exosome component 8 [Source:HGNC Symbol%3BAcc:HGNC:17035]
ENSG00000010626	15.89	15.88	17.02	18.31	17.89	18.13	-0.142158669103017	4.46730907617422	0.0889456581341213	0.399014095503354	12:6873568-6914243:+	LRRC23	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	leucine rich repeat containing 23 [Source:HGNC Symbol%3BAcc:HGNC:19138]
ENSG00000163814	101.26	85.18	105.09	121.41	92.08	117.75	-0.171885553287603	8.0294419550803	0.0889789777865639	0.399014095503354	3:45082277-45146422:-	CDCP1	5;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CUB domain containing protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24357]
ENSG00000160691	100.63	97.92	105.34	97.23	86.94	98.70	0.115478226811606	7.63474327700136	0.089009105812357	0.399014095503354	1:154962297-154974395:-	SHC1	49;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0001784,molecular_function phosphotyrosine binding;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005158,molecular_function insulin receptor binding;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005168,molecular_function neurotrophin TRKA receptor binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007176,biological_process regulation of epidermal growth factor-activated receptor activity;GO:0007265,biological_process Ras protein signal transduction;GO:0007411,biological_process axon guidance;GO:0007507,biological_process heart development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0016032,biological_process viral process;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0035556,biological_process intracellular signal transduction;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0040008,biological_process regulation of growth;GO:0042127,biological_process regulation of cell proliferation;GO:0042742,biological_process defense response to bacterium;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045740,biological_process positive regulation of DNA replication;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046875,molecular_function ephrin receptor binding;GO:0048408,molecular_function epidermal growth factor binding;GO:0050900,biological_process leukocyte migration;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070435,cellular_component Shc-EGFR complex;GO:0071363,biological_process cellular response to growth factor stimulus	SHC1; SHC-transforming protein 1; K06279	SHC adaptor protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10840]
ENSG00000139218	31.23	32.87	31.06	34.04	36.16	33.29	-0.110011484118143	7.25193791095256	0.0890792091249284	0.399184195981132	12:45919130-45992120:-	SCAF11	11;GO:0000245,biological_process spliceosomal complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0046872,molecular_function metal ion binding	NA	SR-related CTD associated factor 11 [Source:HGNC Symbol%3BAcc:HGNC:10784]
ENSG00000156113	28.63	25.71	30.48	33.33	28.26	32.44	-0.135643945095405	7.35848914015057	0.0891994892480042	0.39938419928977	10:76869600-77638369:-	KCNMA1	32;GO:0001666,biological_process response to hypoxia;GO:0003779,molecular_function actin binding;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006970,biological_process response to osmotic stress;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015269,molecular_function calcium-activated potassium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030007,biological_process cellular potassium ion homeostasis;GO:0034465,biological_process response to carbon monoxide;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045794,biological_process negative regulation of cell volume;GO:0046872,molecular_function metal ion binding;GO:0051592,biological_process response to calcium ion;GO:0055085,biological_process transmembrane transport;GO:0060072,molecular_function large conductance calcium-activated potassium channel activity;GO:0060073,biological_process micturition;GO:0060083,biological_process smooth muscle contraction involved in micturition;GO:0070062,cellular_component extracellular exosome;GO:0071805,biological_process potassium ion transmembrane transport	KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1; K04936	potassium calcium-activated channel subfamily M alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:6284]
ENSG00000107551	14.30	11.60	16.44	13.85	10.41	12.24	0.233686960316567	3.99275940320538	0.0891995866766903	0.39938419928977	10:44959406-44995891:+	RASSF4	3;GO:0005515,molecular_function protein binding;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction	RASSF2_4; Ras association domain-containing protein 2/4; K09851	Ras association domain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:20793]
ENSG00000058091	3.78	4.73	4.44	5.07	4.68	5.81	-0.266423184137721	2.84169899913854	0.0892203645074141	0.39938419928977	7:90466423-91210590:+	CDK14	23;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000308,cellular_component cytoplasmic cyclin-dependent protein kinase holoenzyme complex;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030332,molecular_function cyclin binding;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle;GO:0060828,biological_process regulation of canonical Wnt signaling pathway	CDK14, PFTK1; cyclin-dependent kinase 14 [EC:2.7.11.22]; K08821	cyclin dependent kinase 14 [Source:HGNC Symbol%3BAcc:HGNC:8883]
ENSG00000004961	30.92	29.60	30.30	34.83	32.83	33.06	-0.135266651326897	4.69284332846542	0.089261635627664	0.399424903765751	X:11111300-11123078:+	HCCS	9;GO:0004408,molecular_function holocytochrome-c synthase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0018063,biological_process cytochrome c-heme linkage;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	HCCS; cytochrome c heme-lyase [EC:4.4.1.17]; K01764	holocytochrome c synthase [Source:HGNC Symbol%3BAcc:HGNC:4837]
ENSG00000073008	117.86	97.96	120.57	132.98	112.19	130.78	-0.147141454750598	7.24792460939404	0.0893088657940454	0.399492234631166	19:44643797-44663583:+	PVR	32;GO:0001618,molecular_function virus receptor activity;GO:0002860,biological_process positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008037,biological_process cell recognition;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016477,biological_process cell migration;GO:0034332,biological_process adherens junction organization;GO:0042271,biological_process susceptibility to natural killer cell mediated cytotoxicity;GO:0042803,molecular_function protein homodimerization activity;GO:0045503,molecular_function dynein light chain binding;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0046718,biological_process viral entry into host cell;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0060370,biological_process susceptibility to T cell mediated cytotoxicity;GO:0070062,cellular_component extracellular exosome	PVR, NECL5, CD155; poliovirus receptor; K06539	poliovirus receptor [Source:HGNC Symbol%3BAcc:HGNC:9705]
ENSG00000117385	65.94	66.16	66.28	64.03	60.02	62.19	0.102762055985344	7.41861197194607	0.08943081437553	0.399766006488255	1:42746334-42767084:-	P3H1	28;GO:0003674,molecular_function molecular_function;GO:0005506,molecular_function iron ion binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006457,biological_process protein folding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0018126,biological_process protein hydroxylation;GO:0019511,biological_process peptidyl-proline hydroxylation;GO:0019797,molecular_function procollagen-proline 3-dioxygenase activity;GO:0031418,molecular_function L-ascorbic acid binding;GO:0032403,molecular_function protein complex binding;GO:0032963,biological_process collagen metabolic process;GO:0032991,cellular_component macromolecular complex;GO:0046872,molecular_function metal ion binding;GO:0050708,biological_process regulation of protein secretion;GO:0050821,biological_process protein stabilization;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060348,biological_process bone development;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:1901874,biological_process negative regulation of post-translational protein modification	NA	prolyl 3-hydroxylase 1 [Source:HGNC Symbol%3BAcc:HGNC:19316]
ENSG00000168496	30.46	31.77	25.76	28.23	25.35	25.96	0.15343878893181	5.00051704997732	0.0894344799821063	0.399766006488255	11:61792636-61797244:+	FEN1	37;GO:0000287,molecular_function magnesium ion binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006302,biological_process double-strand break repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007613,biological_process memory;GO:0008309,molecular_function double-stranded DNA exodeoxyribonuclease activity;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0009650,biological_process UV protection;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0017108,molecular_function 5'-flap endonuclease activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0043137,biological_process DNA replication, removal of RNA primer;GO:0043234,cellular_component protein complex;GO:0045876,biological_process positive regulation of sister chromatid cohesion;GO:0046872,molecular_function metal ion binding;GO:0048256,molecular_function flap endonuclease activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	FEN1, RAD2; flap endonuclease-1 [EC:3.-.-.-]; K04799	flap structure-specific endonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:3650]
ENSG00000147799	2.32	2.52	2.47	2.78	2.81	2.90	-0.210329978881942	3.1644558304021	0.0894699081111183	0.399780406545468	8:144529178-144605816:-	ARHGAP39	7;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 39 [Source:HGNC Symbol%3BAcc:HGNC:29351]
ENSG00000196368	4.88	4.08	4.04	5.17	6.47	5.72	-0.395542394030171	1.41066128660851	0.0895038027696456	0.399787946664128	X:51490010-51496596:-	NUDT11	25;GO:0000298,molecular_function endopolyphosphatase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008486,molecular_function diphosphoinositol-polyphosphate diphosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0034431,molecular_function bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432,molecular_function bis(5'-adenosyl)-pentaphosphatase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050072,molecular_function m7G(5')pppN diphosphatase activity;GO:0052840,molecular_function inositol diphosphate tetrakisphosphate diphosphatase activity;GO:0052841,molecular_function inositol bisdiphosphate tetrakisphosphate diphosphatase activity;GO:0052842,molecular_function inositol diphosphate pentakisphosphate diphosphatase activity;GO:0052843,molecular_function inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity;GO:0052844,molecular_function inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity;GO:0052845,molecular_function inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity;GO:0052846,molecular_function inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity;GO:0052847,molecular_function inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0052848,molecular_function inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0071543,biological_process diphosphoinositol polyphosphate metabolic process;GO:1901907,biological_process diadenosine pentaphosphate catabolic process;GO:1901909,biological_process diadenosine hexaphosphate catabolic process;GO:1901911,biological_process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	NA	nudix hydrolase 11 [Source:HGNC Symbol%3BAcc:HGNC:18011]
ENSG00000125868	316.85	333.73	315.39	288.81	313.15	301.60	0.107383710327822	7.31957006217043	0.0895907527279294	0.39986510160797	20:17569862-17609919:+	DSTN	13;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0008154,biological_process actin polymerization or depolymerization;GO:0015629,cellular_component actin cytoskeleton;GO:0030042,biological_process actin filament depolymerization;GO:0030043,biological_process actin filament fragmentation;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0051014,biological_process actin filament severing;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	NA	destrin%2C actin depolymerizing factor [Source:HGNC Symbol%3BAcc:HGNC:15750]
ENSG00000136878	7.88	8.54	8.43	7.48	7.41	7.72	0.14381467043199	4.44749490199932	0.0895919991066225	0.39986510160797	9:129834697-129881838:+	USP20	23;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006897,biological_process endocytosis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination	NA	ubiquitin specific peptidase 20 [Source:HGNC Symbol%3BAcc:HGNC:12619]
ENSG00000162613	47.80	49.17	41.46	47.74	56.90	49.39	-0.143468745688553	6.65928772568719	0.0896479633406823	0.39986510160797	1:77944054-77979110:-	FUBP1	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0010628,biological_process positive regulation of gene expression	NA	far upstream element binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4004]
ENSG00000111671	13.19	13.93	14.07	12.53	10.81	12.91	0.192192181412131	3.59608447390957	0.0896499297329397	0.39986510160797	12:6870934-6889358:-	SPSB2	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	splA/ryanodine receptor domain and SOCS box containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29522]
ENSG00000071205	5.66	4.54	5.24	6.45	5.15	6.53	-0.211542247854687	3.74704561785053	0.089755839963144	0.400039711242133	4:147732062-148072780:+	ARHGAP10	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	ARHGAP10; Rho GTPase-activating protein 10; K13736	Rho GTPase activating protein 10 [Source:HGNC Symbol%3BAcc:HGNC:26099]
ENSG00000136521	110.83	127.33	117.59	111.61	116.09	99.11	0.132357792439813	6.31907774958488	0.089772663760279	0.400039711242133	3:179604689-179627647:+	NDUFB5	11;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5; K03961	NADH:ubiquinone oxidoreductase subunit B5 [Source:HGNC Symbol%3BAcc:HGNC:7700]
ENSG00000242372	78.65	90.19	79.63	99.07	90.58	84.97	-0.135362848131013	6.22099157853002	0.089785759729363	0.400039711242133	20:35278906-35284985:-	EIF6	27;GO:0000054,biological_process ribosomal subunit export from nucleus;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0032868,biological_process response to insulin;GO:0035195,biological_process gene silencing by miRNA;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0042254,biological_process ribosome biogenesis;GO:0042256,biological_process mature ribosome assembly;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0043022,molecular_function ribosome binding;GO:0043023,molecular_function ribosomal large subunit binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045727,biological_process positive regulation of translation;GO:0070062,cellular_component extracellular exosome;GO:1902626,biological_process assembly of large subunit precursor of preribosome;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	EIF6; translation initiation factor 6; K03264	eukaryotic translation initiation factor 6 [Source:HGNC Symbol%3BAcc:HGNC:6159]
ENSG00000182534	40.72	38.77	35.95	34.97	35.56	36.29	0.1234079179897	5.38523845890586	0.0898697490041001	0.400270252740543	17:76672550-76711016:-	MXRA7	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	matrix remodeling associated 7 [Source:HGNC Symbol%3BAcc:HGNC:7541]
ENSG00000103023	3.28	3.87	3.79	4.68	3.97	4.81	-0.29609570472523	2.31525638296535	0.0899518713839949	0.400492316890075	16:58279996-58295047:-	PRSS54	3;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0006508,biological_process proteolysis	NA	protease%2C serine 54 [Source:HGNC Symbol%3BAcc:HGNC:26336]
ENSG00000164181	4.43	5.99	4.62	6.83	5.88	5.85	-0.310658888713033	2.33494475282344	0.0900472047750873	0.400573756858403	5:60751790-60844389:-	ELOVL7	20;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0009922,molecular_function fatty acid elongase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0019367,biological_process fatty acid elongation, saturated fatty acid;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034625,biological_process fatty acid elongation, monounsaturated fatty acid;GO:0034626,biological_process fatty acid elongation, polyunsaturated fatty acid;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0102336,molecular_function 3-oxo-arachidoyl-CoA synthase activity;GO:0102337,molecular_function 3-oxo-cerotoyl-CoA synthase activity;GO:0102338,molecular_function 3-oxo-lignoceronyl-CoA synthase activity	ELOVL7; elongation of very long chain fatty acids protein 7 [EC:2.3.1.199]; K10250	ELOVL fatty acid elongase 7 [Source:HGNC Symbol%3BAcc:HGNC:26292]
ENSG00000145781	50.81	53.14	50.65	55.10	55.44	59.53	-0.129244917423725	5.04310318444847	0.0900489847664266	0.400573756858403	5:116084990-116412762:+	COMMD10	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	COMM domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:30201]
ENSG00000141569	8.42	7.18	8.36	7.53	6.31	7.20	0.206368296520152	3.61644609908603	0.0900680585044767	0.400573756858403	17:75880334-75897003:-	TRIM65	7;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0010508,biological_process positive regulation of autophagy;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 65 [Source:HGNC Symbol%3BAcc:HGNC:27316]
ENSG00000159147	21.96	20.54	19.42	21.30	16.79	17.77	0.161066740743319	5.06548115206366	0.0901047481911792	0.400573756858403	21:33559541-33588708:-	DONSON	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process;GO:0033260,biological_process nuclear DNA replication	NA	downstream neighbor of SON [Source:HGNC Symbol%3BAcc:HGNC:2993]
ENSG00000136854	19.14	17.42	18.43	17.46	16.54	16.92	0.126288744220017	5.17845289977832	0.0901694027568404	0.400573756858403	9:127579369-127696027:+	STXBP1	58;GO:0000149,molecular_function SNARE binding;GO:0002576,biological_process platelet degranulation;GO:0003006,biological_process developmental process involved in reproduction;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0007269,biological_process neurotransmitter secretion;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0007412,biological_process axon target recognition;GO:0010807,biological_process regulation of synaptic vesicle priming;GO:0014047,biological_process glutamate secretion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016188,biological_process synaptic vesicle maturation;GO:0016192,biological_process vesicle-mediated transport;GO:0017075,molecular_function syntaxin-1 binding;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0019905,molecular_function syntaxin binding;GO:0030424,cellular_component axon;GO:0031091,cellular_component platelet alpha granule;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031338,biological_process regulation of vesicle fusion;GO:0031630,biological_process regulation of synaptic vesicle fusion to presynaptic membrane;GO:0032229,biological_process negative regulation of synaptic transmission, GABAergic;GO:0032355,biological_process response to estradiol;GO:0035542,biological_process regulation of SNARE complex assembly;GO:0042802,molecular_function identical protein binding;GO:0043195,cellular_component terminal bouton;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043274,molecular_function phospholipase binding;GO:0043306,biological_process positive regulation of mast cell degranulation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045921,biological_process positive regulation of exocytosis;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0047485,molecular_function protein N-terminus binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048787,cellular_component presynaptic active zone membrane;GO:0050821,biological_process protein stabilization;GO:0060292,biological_process long term synaptic depression;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0072659,biological_process protein localization to plasma membrane;GO:0098793,cellular_component presynapse;GO:0098794,cellular_component postsynapse;GO:0099525,biological_process presynaptic dense core vesicle exocytosis;GO:0106022,biological_process positive regulation of vesicle docking;GO:1903296,biological_process positive regulation of glutamate secretion, neurotransmission	STXBP1, MUNC18-1; syntaxin-binding protein 1; K15292	syntaxin binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11444]
ENSG00000203965	6.85	8.41	8.66	7.06	6.83	7.12	0.192402636591336	3.831907310597	0.0901727181474926	0.400573756858403	1:63523371-63572693:+	EFCAB7	9;GO:0005509,molecular_function calcium ion binding;GO:0005929,cellular_component cilium;GO:0019898,cellular_component extrinsic component of membrane;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060170,cellular_component ciliary membrane;GO:0098797,cellular_component plasma membrane protein complex;GO:1903569,biological_process positive regulation of protein localization to ciliary membrane	NA	EF-hand calcium binding domain 7 [Source:HGNC Symbol%3BAcc:HGNC:29379]
ENSG00000263961	7.12	7.96	6.56	5.37	6.32	5.45	0.338305186986915	1.79143667473771	0.0902168632547089	0.400573756858403	1:206037230-206102459:+	C1orf186	3;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 1 open reading frame 186 [Source:HGNC Symbol%3BAcc:HGNC:25341]
ENSG00000071051	34.76	32.69	36.28	41.38	34.00	40.22	-0.142433520575192	5.38948544494562	0.0902283270906384	0.400573756858403	2:105744896-105894274:+	NCK2	36;GO:0001771,biological_process immunological synapse formation;GO:0001784,molecular_function phosphotyrosine binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0007015,biological_process actin filament organization;GO:0007165,biological_process signal transduction;GO:0007172,biological_process signal complex assembly;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007176,biological_process regulation of epidermal growth factor-activated receptor activity;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0012506,cellular_component vesicle membrane;GO:0014069,cellular_component postsynaptic density;GO:0016477,biological_process cell migration;GO:0030032,biological_process lamellipodium assembly;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0032403,molecular_function protein complex binding;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0036493,biological_process positive regulation of translation in response to endoplasmic reticulum stress;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042110,biological_process T cell activation;GO:0045202,cellular_component synapse;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0060996,biological_process dendritic spine development;GO:0097110,molecular_function scaffold protein binding;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903898,biological_process negative regulation of PERK-mediated unfolded protein response;GO:1903912,biological_process negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:1990441,biological_process negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	NCK1; NCK adaptor protein 1; K07365	NCK adaptor protein 2 [Source:HGNC Symbol%3BAcc:HGNC:7665]
ENSG00000183617	37.26	31.92	28.21	39.92	33.53	39.10	-0.1955910037195	4.22096992293036	0.0903913817984452	0.401154173136968	19:3762663-3768575:+	MRPL54	8;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L54 [Source:HGNC Symbol%3BAcc:HGNC:16685]
ENSG00000161677	35.31	32.36	32.10	30.00	33.08	25.56	0.18688623573064	4.15817866233087	0.0904685327386771	0.401270577371513	19:50505997-50511353:-	JOSD2	8;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	Josephin domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28853]
ENSG00000169242	29.74	29.68	29.92	25.20	28.24	27.33	0.157272168328998	4.13599647951797	0.0904955332456056	0.401270577371513	1:155127459-155134857:+	EFNA1	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003180,biological_process aortic valve morphogenesis;GO:0003183,biological_process mitral valve morphogenesis;GO:0003199,biological_process endocardial cushion to mesenchymal transition involved in heart valve formation;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007267,biological_process cell-cell signaling;GO:0007411,biological_process axon guidance;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0014028,biological_process notochord formation;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0030182,biological_process neuron differentiation;GO:0031225,cellular_component anchored component of membrane;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0043535,biological_process regulation of blood vessel endothelial cell migration;GO:0045765,biological_process regulation of angiogenesis;GO:0046658,cellular_component anchored component of plasma membrane;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050770,biological_process regulation of axonogenesis;GO:0050821,biological_process protein stabilization;GO:0061002,biological_process negative regulation of dendritic spine morphogenesis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070244,biological_process negative regulation of thymocyte apoptotic process;GO:1902004,biological_process positive regulation of beta-amyloid formation;GO:1902961,biological_process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1903051,biological_process negative regulation of proteolysis involved in cellular protein catabolic process	EFNA; ephrin-A; K05462	ephrin A1 [Source:HGNC Symbol%3BAcc:HGNC:3221]
ENSG00000149591	4.68	4.75	5.37	4.84	2.77	3.62	0.412030658937371	1.4658834597346	0.0905228974902846	0.401270577371513	11:117199320-117204782:+	TAGLN	6;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007517,biological_process muscle organ development;GO:0030855,biological_process epithelial cell differentiation;GO:0051015,molecular_function actin filament binding	NA	transgelin [Source:HGNC Symbol%3BAcc:HGNC:11553]
ENSG00000163660	70.87	67.90	72.91	62.39	65.24	69.82	0.11292585007241	6.8626664517042	0.0905469175233713	0.401270577371513	3:157146507-157160760:-	CCNL1	14;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0016607,cellular_component nuclear speck;GO:0019901,molecular_function protein kinase binding;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1901409,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain	NA	cyclin L1 [Source:HGNC Symbol%3BAcc:HGNC:20569]
ENSG00000141252	8.31	8.89	7.32	7.19	7.90	6.92	0.162982006235699	4.5248042869168	0.0906756170649478	0.40140850083802	17:508667-721717:-	VPS53	17;GO:0000938,cellular_component GARP complex;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0007041,biological_process lysosomal transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0032456,biological_process endocytic recycling;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:1990745,cellular_component EARP complex	NA	VPS53%2C GARP complex subunit [Source:HGNC Symbol%3BAcc:HGNC:25608]
ENSG00000135596	19.16	19.01	19.27	18.80	17.53	17.31	0.111147391498437	5.91859416732284	0.0906952941227293	0.40140850083802	6:109444061-109465968:-	MICAL1	25;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003779,molecular_function actin binding;GO:0004497,molecular_function monooxygenase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0016491,molecular_function oxidoreductase activity;GO:0016709,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0017124,molecular_function SH3 domain binding;GO:0017137,molecular_function Rab GTPase binding;GO:0019417,biological_process sulfur oxidation;GO:0019901,molecular_function protein kinase binding;GO:0030042,biological_process actin filament depolymerization;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding;GO:1903305,biological_process regulation of regulated secretory pathway;GO:1990026,cellular_component hippocampal mossy fiber expansion	NA	microtubule associated monooxygenase%2C calponin and LIM domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20619]
ENSG00000116539	11.77	10.71	12.34	10.70	10.87	10.84	0.117182447546024	6.67834715835273	0.0907165182635218	0.40140850083802	1:155335267-155562807:-	ASH1L	40;GO:0001501,biological_process skeletal system development;GO:0002674,biological_process negative regulation of acute inflammatory response;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0005923,cellular_component bicellular tight junction;GO:0006323,biological_process DNA packaging;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007267,biological_process cell-cell signaling;GO:0007338,biological_process single fertilization;GO:0008168,molecular_function methyltransferase activity;GO:0009791,biological_process post-embryonic development;GO:0010468,biological_process regulation of gene expression;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030054,cellular_component cell junction;GO:0032259,biological_process methylation;GO:0032635,biological_process interleukin-6 production;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046697,biological_process decidualization;GO:0046872,molecular_function metal ion binding;GO:0046975,molecular_function histone methyltransferase activity (H3-K36 specific);GO:0048733,biological_process sebaceous gland development;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051568,biological_process histone H3-K4 methylation;GO:0061038,biological_process uterus morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097676,biological_process histone H3-K36 dimethylation;GO:0097722,biological_process sperm motility;GO:1903699,biological_process tarsal gland development;GO:1903709,biological_process uterine gland development	ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]; K06101	ASH1 like histone lysine methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:19088]
ENSG00000124098	17.44	24.48	17.04	15.71	17.09	17.04	0.239435740299575	3.55968105067352	0.0907390599253252	0.40140850083802	20:56358914-56368663:+	FAM210B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 210 member B [Source:HGNC Symbol%3BAcc:HGNC:16102]
ENSG00000104388	210.07	253.62	214.46	197.22	221.52	202.92	0.136007480761409	7.53918292486556	0.0907708069505897	0.40140850083802	8:60516856-60623627:+	RAB2A	22;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019003,molecular_function GDP binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042470,cellular_component melanosome;GO:0043687,biological_process post-translational protein modification;GO:0070062,cellular_component extracellular exosome	RAB2A; Ras-related protein Rab-2A; K07877	RAB2A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9763]
ENSG00000106263	139.20	138.53	132.34	152.63	143.08	147.81	-0.101507981047564	8.44199459795014	0.0907720665312432	0.40140850083802	7:2354085-2380745:+	EIF3B	19;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0031369,molecular_function translation initiation factor binding;GO:0032947,molecular_function protein complex scaffold;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0070062,cellular_component extracellular exosome;GO:0071541,cellular_component eukaryotic translation initiation factor 3 complex, eIF3m;GO:0075522,biological_process IRES-dependent viral translational initiation;GO:0075525,biological_process viral translational termination-reinitiation	EIF3B; translation initiation factor 3 subunit B; K03253	eukaryotic translation initiation factor 3 subunit B [Source:HGNC Symbol%3BAcc:HGNC:3280]
ENSG00000140718	17.52	18.72	17.74	16.59	16.77	16.74	0.116419537493517	5.32406424591793	0.0908282703858619	0.401514002955735	16:53701691-54158512:+	FTO	29;GO:0001659,biological_process temperature homeostasis;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008198,molecular_function ferrous iron binding;GO:0010883,biological_process regulation of lipid storage;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016607,cellular_component nuclear speck;GO:0035515,molecular_function oxidative RNA demethylase activity;GO:0035516,molecular_function oxidative DNA demethylase activity;GO:0035552,biological_process oxidative single-stranded DNA demethylation;GO:0035553,biological_process oxidative single-stranded RNA demethylation;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042245,biological_process RNA repair;GO:0043734,molecular_function DNA-N1-methyladenine dioxygenase activity;GO:0044065,biological_process regulation of respiratory system process;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060612,biological_process adipose tissue development;GO:0070350,biological_process regulation of white fat cell proliferation;GO:0070989,biological_process oxidative demethylation;GO:0080111,biological_process DNA demethylation;GO:0090335,biological_process regulation of brown fat cell differentiation;GO:1990931,molecular_function RNA N6-methyladenosine dioxygenase activity	NA	FTO%2C alpha-ketoglutarate dependent dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:24678]
ENSG00000130414	66.32	64.09	65.24	71.63	70.14	70.16	-0.102929942756191	6.95456827959893	0.090913697459903	0.40174856766457	2:239892449-240025402:-	NDUFA10	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005759,cellular_component mitochondrial matrix;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0043209,cellular_component myelin sheath;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10; K03954	NADH:ubiquinone oxidoreductase subunit A10 [Source:HGNC Symbol%3BAcc:HGNC:7684]
ENSG00000170348	175.01	178.52	178.84	171.83	165.89	160.78	0.106450072851513	6.92284068963983	0.0909626784588031	0.401821967156271	14:75131469-75176631:-	TMED10	42;GO:0000139,cellular_component Golgi membrane;GO:0001822,biological_process kidney development;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030133,cellular_component transport vesicle;GO:0030137,cellular_component COPI-coated vesicle;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030658,cellular_component transport vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032403,molecular_function protein complex binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035459,biological_process cargo loading into vesicle;GO:0035964,biological_process COPI-coated vesicle budding;GO:0042470,cellular_component melanosome;GO:0042589,cellular_component zymogen granule membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043279,biological_process response to alkaloid;GO:0045055,biological_process regulated exocytosis;GO:0048199,biological_process vesicle targeting, to, from or within Golgi;GO:0048205,biological_process COPI coating of Golgi vesicle;GO:0048208,biological_process COPII vesicle coating;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome;GO:0070765,cellular_component gamma-secretase complex;GO:1902003,biological_process regulation of beta-amyloid formation	NA	transmembrane p24 trafficking protein 10 [Source:HGNC Symbol%3BAcc:HGNC:16998]
ENSG00000100104	15.07	14.85	13.82	17.08	15.36	17.01	-0.167422764807098	3.99767208574782	0.0910726091254998	0.402164460005276	22:26483876-26494658:+	SRRD	1;GO:0048511,biological_process rhythmic process	NA	SRR1 domain containing [Source:HGNC Symbol%3BAcc:HGNC:33910]
ENSG00000100014	4.53	4.76	4.92	5.30	5.18	5.52	-0.160793735673325	4.09182686155362	0.091173650280605	0.402420663892444	22:24270816-24417740:+	SPECC1L	10;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005921,cellular_component gap junction;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0015629,cellular_component actin cytoskeleton;GO:0030054,cellular_component cell junction;GO:0051301,biological_process cell division	NA	sperm antigen with calponin homology and coiled-coil domains 1 like [Source:HGNC Symbol%3BAcc:HGNC:29022]
ENSG00000124532	32.02	35.85	32.22	35.17	38.76	36.03	-0.127985030450587	5.62436092141694	0.0911954666502413	0.402420663892444	6:24402907-24426194:+	MRS2	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006089,biological_process lactate metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:1990614,biological_process mitochondrial magnesium ion transmembrane transport	NA	MRS2%2C magnesium transporter [Source:HGNC Symbol%3BAcc:HGNC:13785]
ENSG00000164924	807.59	818.42	780.81	858.13	866.97	868.11	-0.0959376365194945	9.43157829606712	0.0912290205720909	0.40242566892728	8:100916524-100953388:-	YWHAZ	35;GO:0003723,molecular_function RNA binding;GO:0004497,molecular_function monooxygenase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006605,biological_process protein targeting;GO:0007165,biological_process signal transduction;GO:0008134,molecular_function transcription factor binding;GO:0010941,biological_process regulation of cell death;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030168,biological_process platelet activation;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031982,cellular_component vesicle;GO:0042470,cellular_component melanosome;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043488,biological_process regulation of mRNA stability;GO:0044325,molecular_function ion channel binding;GO:0045296,molecular_function cadherin binding;GO:0051683,biological_process establishment of Golgi localization;GO:0055114,biological_process oxidation-reduction process;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle;GO:0090168,biological_process Golgi reassembly;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta; K16197	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol%3BAcc:HGNC:12855]
ENSG00000185730	4.37	3.72	3.99	4.35	5.04	5.26	-0.258682259345769	2.5902146657811	0.091312781060893	0.402652060855725	8:143289675-143298061:+	ZNF696	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 696 [Source:HGNC Symbol%3BAcc:HGNC:25872]
ENSG00000115866	113.91	111.17	109.47	118.12	117.49	126.89	-0.104038971915682	7.55568327530065	0.0913755316676229	0.402742870816046	2:135906676-135986100:-	DARS	18;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004046,molecular_function aminoacylase activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004815,molecular_function aspartate-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006422,biological_process aspartyl-tRNA aminoacylation;GO:0006461,biological_process protein complex assembly;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0070062,cellular_component extracellular exosome	aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]; K01876	aspartyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:2678]
ENSG00000180878	0.64	1.15	1.03	0.37	0.30	0.92	0.775120079858648	-0.193689251192651	0.091403504137561	0.402742870816046	11:6205565-6211132:+	C11orf42	NA	NA	chromosome 11 open reading frame 42 [Source:HGNC Symbol%3BAcc:HGNC:28541]
ENSG00000153914	16.64	19.25	16.76	15.05	17.15	15.73	0.14171933656507	5.08840743475557	0.0914397755513538	0.402742870816046	5:66139970-66183615:+	SREK1	10;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck	NA	splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17882]
ENSG00000157916	156.02	146.22	145.09	136.01	141.25	141.14	0.10894068614199	6.65730976174466	0.0914659808915803	0.402742870816046	1:2391774-2405444:+	RER1	14;GO:0000139,cellular_component Golgi membrane;GO:0003674,molecular_function molecular_function;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007528,biological_process neuromuscular junction development;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030173,cellular_component integral component of Golgi membrane;GO:0033130,molecular_function acetylcholine receptor binding;GO:0071340,biological_process skeletal muscle acetylcholine-gated channel clustering;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane	NA	retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:30309]
ENSG00000179922	2.88	2.75	2.49	1.86	2.04	2.31	0.394944010285629	1.34865150221013	0.0915132629118579	0.402742870816046	19:55620741-55624601:-	ZNF784	7;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 784 [Source:HGNC Symbol%3BAcc:HGNC:33111]
ENSG00000125386	8.52	8.52	9.55	9.44	10.25	9.61	-0.126077870765064	5.48974054834942	0.0915280462879292	0.402742870816046	4:2536630-2732565:+	FAM193A	NA	NA	family with sequence similarity 193 member A [Source:HGNC Symbol%3BAcc:HGNC:16822]
ENSG00000125821	97.26	72.09	95.73	109.04	88.77	104.58	-0.174805242175588	6.14663354034552	0.0915783369963283	0.402821366809151	20:18567452-18763917:+	DTD1	15;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006399,biological_process tRNA metabolic process;GO:0006450,biological_process regulation of translational fidelity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0051499,molecular_function D-aminoacyl-tRNA deacylase activity;GO:0051500,molecular_function D-tyrosyl-tRNA(Tyr) deacylase activity	NA	D-tyrosyl-tRNA deacylase 1 [Source:HGNC Symbol%3BAcc:HGNC:16219]
ENSG00000124535	29.35	27.69	27.63	31.71	30.83	29.71	-0.110483690526376	5.88381892036443	0.0916484015561739	0.402986754699535	6:2765413-2786952:+	WRNIP1	17;GO:0000166,molecular_function nucleotide binding;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030174,biological_process regulation of DNA-dependent DNA replication initiation;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	Werner helicase interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20876]
ENSG00000272031	0.62	0.90	0.99	1.36	1.17	1.09	-0.525652211543098	0.741641715335672	0.0920090218176002	0.404429174157887	1:145959441-145964582:-	ANKRD34A	NA	NA	ankyrin repeat domain 34A [Source:HGNC Symbol%3BAcc:HGNC:27639]
ENSG00000162542	12.06	13.34	13.64	14.56	13.72	15.13	-0.144448644561519	4.77882952622592	0.0920437607803509	0.404438655775751	1:19682212-19799945:-	TMCO4	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane and coiled-coil domains 4 [Source:HGNC Symbol%3BAcc:HGNC:27393]
ENSG00000214753	6.81	6.35	7.32	7.72	8.19	7.34	-0.163989127228646	4.04748352837124	0.0921049419450551	0.404536375596037	11:62712629-62727349:-	HNRNPUL2	5;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane	NA	heterogeneous nuclear ribonucleoprotein U like 2 [Source:HGNC Symbol%3BAcc:HGNC:25451]
ENSG00000005483	22.89	24.95	24.90	20.72	24.65	21.73	0.127549297721987	7.0642083338135	0.0921311797156204	0.404536375596037	7:105014178-105114361:+	KMT2E	23;GO:0002446,biological_process neutrophil mediated immunity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006306,biological_process DNA methylation;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030218,biological_process erythrocyte differentiation;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0042119,biological_process neutrophil activation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding	MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]; K09189	lysine methyltransferase 2E [Source:HGNC Symbol%3BAcc:HGNC:18541]
ENSG00000147471	15.55	18.85	15.28	19.23	18.18	19.19	-0.188550833350935	3.96095513492606	0.0922804879914664	0.405048690748965	8:37762592-37779767:+	PLPBP	6;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0070062,cellular_component extracellular exosome	NA	pyridoxal phosphate binding protein [Source:HGNC Symbol%3BAcc:HGNC:9457]
ENSG00000178252	45.69	47.89	47.27	42.92	46.41	42.36	0.108463979107975	7.37991050974444	0.0924051601677688	0.405118476195584	3:49007061-49015953:+	WDR6	12;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008180,cellular_component COP9 signalosome;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010507,biological_process negative regulation of autophagy;GO:0043234,cellular_component protein complex;GO:0043560,molecular_function insulin receptor substrate binding	NA	WD repeat domain 6 [Source:HGNC Symbol%3BAcc:HGNC:12758]
ENSG00000179057	0.41	0.58	0.72	0.41	0.46	0.37	0.464242557620037	1.06455940606903	0.0924129116622093	0.405118476195584	11:18704304-18726230:-	IGSF22	11;GO:0005859,cellular_component muscle myosin complex;GO:0006941,biological_process striated muscle contraction;GO:0007015,biological_process actin filament organization;GO:0008307,molecular_function structural constituent of muscle;GO:0030018,cellular_component Z disc;GO:0031430,cellular_component M band;GO:0045214,biological_process sarcomere organization;GO:0051015,molecular_function actin filament binding;GO:0051371,molecular_function muscle alpha-actinin binding;GO:0071688,biological_process striated muscle myosin thick filament assembly;GO:0097493,molecular_function structural molecule activity conferring elasticity	NA	immunoglobulin superfamily member 22 [Source:HGNC Symbol%3BAcc:HGNC:26750]
ENSG00000150433	44.08	40.44	43.33	39.29	39.98	36.41	0.161800504555527	4.11535905942943	0.0924305270951138	0.405118476195584	11:125096544-125111763:-	TMEM218	5;GO:0005515,molecular_function protein binding;GO:0005929,cellular_component cilium;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042995,cellular_component cell projection	NA	transmembrane protein 218 [Source:HGNC Symbol%3BAcc:HGNC:27344]
ENSG00000273559	28.05	29.73	27.80	25.26	26.15	27.66	0.122067596134301	5.20244248031234	0.0924499928247223	0.405118476195584	17:38800433-38825481:-	CWC25	3;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005654,cellular_component nucleoplasm;GO:0016607,cellular_component nuclear speck	NA	CWC25 spliceosome associated protein homolog [Source:HGNC Symbol%3BAcc:HGNC:25989]
ENSG00000143190	3.27	3.89	3.05	2.68	3.09	2.89	0.237400014729541	2.98327621947987	0.0924595700525327	0.405118476195584	1:167220828-167427345:+	POU2F1	17;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0090575,cellular_component RNA polymerase II transcription factor complex	POU2F, OTF; POU domain transcription factor, class 2; K09364	POU class 2 homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:9212]
ENSG00000124172	787.96	695.19	689.83	775.15	806.01	794.18	-0.11542628432596	6.86127727090187	0.0925245143042836	0.405163800655251	20:59025466-59032382:-	ATP5E	19;GO:0000275,cellular_component mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005759,cellular_component mitochondrial matrix;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045261,cellular_component proton-transporting ATP synthase complex, catalytic core F(1);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF1E, ATP5E, ATP15; F-type H+-transporting ATPase subunit epsilon; K02135	ATP synthase%2C H+ transporting%2C mitochondrial F1 complex%2C epsilon subunit [Source:HGNC Symbol%3BAcc:HGNC:838]
ENSG00000084733	232.71	214.86	256.62	259.68	246.74	267.09	-0.122263994167832	7.21053972626835	0.0925417846384265	0.405163800655251	2:26034106-26137454:+	RAB10	54;GO:0000139,cellular_component Golgi membrane;GO:0000145,cellular_component exocyst;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0007409,biological_process axonogenesis;GO:0009306,biological_process protein secretion;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016197,biological_process endosomal transport;GO:0017157,biological_process regulation of exocytosis;GO:0019003,molecular_function GDP binding;GO:0019882,biological_process antigen processing and presentation;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030859,biological_process polarized epithelial cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0032593,cellular_component insulin-responsive compartment;GO:0032869,biological_process cellular response to insulin stimulus;GO:0042995,cellular_component cell projection;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043312,biological_process neutrophil degranulation;GO:0045200,biological_process establishment of neuroblast polarity;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0061467,biological_process basolateral protein localization;GO:0070062,cellular_component extracellular exosome;GO:0070382,cellular_component exocytic vesicle;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0071786,biological_process endoplasmic reticulum tubular network organization;GO:0072659,biological_process protein localization to plasma membrane;GO:0090150,biological_process establishment of protein localization to membrane;GO:0097051,biological_process establishment of protein localization to endoplasmic reticulum membrane;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	NA	RAB10%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9759]
ENSG00000072736	5.90	6.27	6.18	6.03	6.92	7.80	-0.168822892380008	4.62186777396927	0.0925837429053437	0.405163800655251	16:68084750-68229259:+	NFATC3	19;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter	NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3; K17333	nuclear factor of activated T-cells 3 [Source:HGNC Symbol%3BAcc:HGNC:7777]
ENSG00000171953	24.11	24.25	22.84	28.24	25.63	25.71	-0.150059927308366	4.45676805775668	0.0926004755062393	0.405163800655251	17:17977408-18039209:-	ATPAF2	5;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016607,cellular_component nuclear speck;GO:0043461,biological_process proton-transporting ATP synthase complex assembly	NA	ATP synthase mitochondrial F1 complex assembly factor 2 [Source:HGNC Symbol%3BAcc:HGNC:18802]
ENSG00000172748	1.89	2.31	2.38	2.28	2.83	3.19	-0.332014803870104	2.05422951308411	0.0926801517254559	0.405369529023285	8:232136-264703:+	ZNF596	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 596 [Source:HGNC Symbol%3BAcc:HGNC:27268]
ENSG00000149257	179.12	173.25	176.89	160.16	168.44	169.27	0.100257868749732	7.76857347187513	0.0927883301284243	0.405699732963766	11:75562055-75572783:+	SERPINH1	18;GO:0003433,biological_process chondrocyte development involved in endochondral bone morphogenesis;GO:0003723,molecular_function RNA binding;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005518,molecular_function collagen binding;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006986,biological_process response to unfolded protein;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030199,biological_process collagen fibril organization;GO:0032964,biological_process collagen biosynthetic process;GO:0045121,cellular_component membrane raft;GO:0051082,molecular_function unfolded protein binding;GO:0051604,biological_process protein maturation;GO:0070062,cellular_component extracellular exosome	NA	serpin family H member 1 [Source:HGNC Symbol%3BAcc:HGNC:1546]
ENSG00000143543	119.41	118.44	111.65	112.63	111.19	99.96	0.122045069230841	5.73086313832509	0.0929188666376504	0.405918347702753	1:153974268-153977688:-	JTB	19;GO:0000278,biological_process mitotic cell cycle;GO:0000910,biological_process cytokinesis;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0030496,cellular_component midbody;GO:0042127,biological_process regulation of cell proliferation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0051301,biological_process cell division	NA	jumping translocation breakpoint [Source:HGNC Symbol%3BAcc:HGNC:6201]
ENSG00000173210	45.00	38.25	48.86	53.34	42.61	53.57	-0.165009392952383	6.67294840487035	0.0929335579287318	0.405918347702753	5:149141482-149260542:+	ABLIM3	13;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0007010,biological_process cytoskeleton organization;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	ABLIM; actin-binding LIM protein; K07520	actin binding LIM protein family member 3 [Source:HGNC Symbol%3BAcc:HGNC:29132]
ENSG00000135338	6.18	5.96	5.51	6.69	6.42	7.00	-0.178247194531928	3.77680990742966	0.0929364331081304	0.405918347702753	6:79484990-79537458:-	LCA5	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0032403,molecular_function protein complex binding;GO:0042995,cellular_component cell projection	NA	LCA5%2C lebercilin [Source:HGNC Symbol%3BAcc:HGNC:31923]
ENSG00000179933	127.46	136.75	127.93	125.14	125.14	113.01	0.12017589800931	5.72782969894189	0.0930168380260986	0.406126630467099	14:23094764-23100462:+	C14orf119	2;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol	NA	chromosome 14 open reading frame 119 [Source:HGNC Symbol%3BAcc:HGNC:20270]
ENSG00000136925	9.73	10.23	11.32	11.66	10.84	13.12	-0.176610228812133	4.13705029111417	0.0931594916272694	0.406488471658324	9:97600079-97633575:-	TSTD2	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	thiosulfate sulfurtransferase like domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30087]
ENSG00000074964	12.23	12.16	12.80	12.11	11.44	11.04	0.117601113274221	5.59909727011918	0.0931652059830767	0.406488471658324	1:17539834-17697874:+	ARHGEF10L	9;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0032933,biological_process SREBP signaling pathway;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051496,biological_process positive regulation of stress fiber assembly	NA	Rho guanine nucleotide exchange factor 10 like [Source:HGNC Symbol%3BAcc:HGNC:25540]
ENSG00000181649	32.68	25.99	28.89	33.82	30.10	37.78	-0.197541958959825	3.87022729443562	0.0933144254806336	0.406996473468414	11:2928272-2929455:-	PHLDA2	11;GO:0001890,biological_process placenta development;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0009887,biological_process organ morphogenesis;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0030334,biological_process regulation of cell migration;GO:0045995,biological_process regulation of embryonic development;GO:0060721,biological_process regulation of spongiotrophoblast cell proliferation;GO:0070873,biological_process regulation of glycogen metabolic process;GO:1903547,biological_process regulation of growth hormone activity	NA	pleckstrin homology like domain family A member 2 [Source:HGNC Symbol%3BAcc:HGNC:12385]
ENSG00000111674	86.92	83.43	92.84	82.13	73.68	87.54	0.125549103858492	6.8154395647142	0.0933895588780704	0.407181100932029	12:6913744-6923698:+	ENO2	15;GO:0000015,cellular_component phosphopyruvate hydratase complex;GO:0000287,molecular_function magnesium ion binding;GO:0004634,molecular_function phosphopyruvate hydratase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0046872,molecular_function metal ion binding;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome	ENO, eno; enolase [EC:4.2.1.11]; K01689	enolase 2 [Source:HGNC Symbol%3BAcc:HGNC:3353]
ENSG00000166337	46.11	43.55	45.47	40.18	43.60	40.64	0.133864153824185	4.83079684301911	0.0934935410228435	0.407358455668861	11:6606295-6612667:-	TAF10	36;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000125,cellular_component PCAF complex;GO:0001889,biological_process liver development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0010468,biological_process regulation of gene expression;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019899,molecular_function enzyme binding;GO:0030331,molecular_function estrogen receptor binding;GO:0030914,cellular_component STAGA complex;GO:0033276,cellular_component transcription factor TFTC complex;GO:0035264,biological_process multicellular organism growth;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043623,biological_process cellular protein complex assembly;GO:0043966,biological_process histone H3 acetylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051101,biological_process regulation of DNA binding;GO:0051260,biological_process protein homooligomerization;GO:0070063,molecular_function RNA polymerase binding;GO:0070365,biological_process hepatocyte differentiation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF10; transcription initiation factor TFIID subunit 10; K03134	TATA-box binding protein associated factor 10 [Source:HGNC Symbol%3BAcc:HGNC:11543]
ENSG00000096080	35.31	36.93	34.71	39.01	42.88	36.90	-0.141025760445868	4.93702251521175	0.0934958704745496	0.407358455668861	6:43671302-43687791:-	MRPS18A	12;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18; K02963	mitochondrial ribosomal protein S18A [Source:HGNC Symbol%3BAcc:HGNC:14515]
ENSG00000172315	9.80	8.63	8.09	6.37	8.64	7.09	0.279587517760801	2.66357566785112	0.0935441454068268	0.407382835503588	20:46684364-46689779:-	TP53RK	20;GO:0000166,molecular_function nucleotide binding;GO:0000408,cellular_component EKC/KEOPS complex;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0008033,biological_process tRNA processing;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0016787,molecular_function hydrolase activity;GO:0070525,biological_process tRNA threonylcarbamoyladenosine metabolic process;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	TP53 regulating kinase [Source:HGNC Symbol%3BAcc:HGNC:16197]
ENSG00000117153	19.81	19.24	19.43	21.87	20.02	22.36	-0.123714070504343	5.22494727707344	0.0935671041666582	0.407382835503588	1:202891099-202928636:-	KLHL12	21;GO:0000139,cellular_component Golgi membrane;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006513,biological_process protein monoubiquitination;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0014029,biological_process neural crest formation;GO:0014032,biological_process neural crest cell development;GO:0016055,biological_process Wnt signaling pathway;GO:0016192,biological_process vesicle-mediated transport;GO:0016567,biological_process protein ubiquitination;GO:0030127,cellular_component COPII vesicle coat;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048208,biological_process COPII vesicle coating;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	kelch like family member 12 [Source:HGNC Symbol%3BAcc:HGNC:19360]
ENSG00000166971	29.43	23.51	27.64	33.00	26.65	32.05	-0.169141720490881	4.85181264479164	0.093800786710493	0.40817322248695	16:53491039-53504411:-	AKTIP	19;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0030897,cellular_component HOPS complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032092,biological_process positive regulation of protein binding;GO:0045022,biological_process early endosome to late endosome transport;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070695,cellular_component FHF complex	NA	AKT interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16710]
ENSG00000178078	7.41	7.03	6.99	8.07	7.80	8.83	-0.193186765623049	3.4537641984688	0.0938144045561321	0.40817322248695	19:4324042-4342786:-	STAP2	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein	NA	signal transducing adaptor family member 2 [Source:HGNC Symbol%3BAcc:HGNC:30430]
ENSG00000026652	16.08	14.51	14.93	17.67	15.91	17.28	-0.144533906394702	4.55410288398766	0.0938957634640152	0.408241438092856	6:161129978-161274061:-	AGPAT4	12;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups	AGPAT3_4; lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]; K13523	1-acylglycerol-3-phosphate O-acyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:20885]
ENSG00000089123	5.40	7.44	6.59	5.61	5.80	4.96	0.247316763530449	3.04998097777016	0.0939234061233905	0.408241438092856	20:13389391-13638940:-	TASP1	5;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	taspase 1 [Source:HGNC Symbol%3BAcc:HGNC:15859]
ENSG00000137312	184.06	184.37	175.67	164.02	172.78	174.64	0.100865555777773	7.97350383436588	0.0939287478605653	0.408241438092856	6:30727708-30742733:-	FLOT1	57;GO:0001765,biological_process membrane raft assembly;GO:0001819,biological_process positive regulation of cytokine production;GO:0001931,cellular_component uropod;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002020,molecular_function protease binding;GO:0002090,biological_process regulation of receptor internalization;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005815,cellular_component microtubule organizing center;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0007409,biological_process axonogenesis;GO:0008180,cellular_component COP9 signalosome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016600,cellular_component flotillin complex;GO:0022617,biological_process extracellular matrix disassembly;GO:0030027,cellular_component lamellipodium;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032092,biological_process positive regulation of protein binding;GO:0032226,biological_process positive regulation of synaptic transmission, dopaminergic;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0033227,biological_process dsRNA transport;GO:0034116,biological_process positive regulation of heterotypic cell-cell adhesion;GO:0034141,biological_process positive regulation of toll-like receptor 3 signaling pathway;GO:0034451,cellular_component centriolar satellite;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0042383,cellular_component sarcolemma;GO:0042470,cellular_component melanosome;GO:0044291,cellular_component cell-cell contact zone;GO:0044853,cellular_component plasma membrane raft;GO:0044854,biological_process plasma membrane raft assembly;GO:0045121,cellular_component membrane raft;GO:0045807,biological_process positive regulation of endocytosis;GO:0046982,molecular_function protein heterodimerization activity;GO:0048643,biological_process positive regulation of skeletal muscle tissue development;GO:0050821,biological_process protein stabilization;GO:0051260,biological_process protein homooligomerization;GO:0060355,biological_process positive regulation of cell adhesion molecule production;GO:0070062,cellular_component extracellular exosome;GO:0070528,biological_process protein kinase C signaling;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0072659,biological_process protein localization to plasma membrane;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:1901741,biological_process positive regulation of myoblast fusion;GO:1901890,biological_process positive regulation of cell junction assembly;GO:1903044,biological_process protein localization to membrane raft;GO:2000049,biological_process positive regulation of cell-cell adhesion mediated by cadherin	FLOT; flotillin; K07192	flotillin 1 [Source:HGNC Symbol%3BAcc:HGNC:3757]
ENSG00000115204	53.16	55.83	55.16	52.76	51.83	47.90	0.117282917063908	5.63339002833854	0.0940386788316194	0.408540787420733	2:27309491-27325680:-	MPV17	12;GO:0000002,biological_process mitochondrial genome maintenance;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005777,cellular_component peroxisome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032836,biological_process glomerular basement membrane development;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0042592,biological_process homeostatic process;GO:0048839,biological_process inner ear development;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	MPV17; protein Mpv17; K13348	MPV17%2C mitochondrial inner membrane protein [Source:HGNC Symbol%3BAcc:HGNC:7224]
ENSG00000004766	13.04	14.46	13.78	11.63	13.39	12.96	0.128552299123915	5.39339687139439	0.0940845100790543	0.408540787420733	7:93232339-93361121:+	VPS50	9;GO:0000149,molecular_function SNARE binding;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0032456,biological_process endocytic recycling;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:1990745,cellular_component EARP complex	NA	VPS50%2C EARP/GARPII complex subunit [Source:HGNC Symbol%3BAcc:HGNC:25956]
ENSG00000165516	55.16	56.07	52.30	52.31	48.92	51.43	0.109391884819002	6.04617662556141	0.0940963595614176	0.408540787420733	14:49767607-49786385:+	KLHDC2	3;GO:0005634,cellular_component nucleus;GO:0016604,cellular_component nuclear body;GO:0031965,cellular_component nuclear membrane	NA	kelch domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20231]
ENSG00000003756	73.14	68.00	72.87	63.61	68.07	68.82	0.106747483574647	7.45022066302301	0.0941334491684008	0.408558917666909	3:50088907-50119021:+	RBM5	19;GO:0000245,biological_process spliceosomal complex assembly;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008380,biological_process RNA splicing;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046872,molecular_function metal ion binding	NA	RNA binding motif protein 5 [Source:HGNC Symbol%3BAcc:HGNC:9902]
ENSG00000184304	11.37	11.10	10.77	12.18	11.61	12.72	-0.124803197215791	5.09317490808687	0.0942373288233331	0.408669027536649	14:29576478-30191898:-	PRKD1	72;GO:0000166,molecular_function nucleotide binding;GO:0000421,cellular_component autophagosome membrane;GO:0001525,biological_process angiogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007030,biological_process Golgi organization;GO:0007165,biological_process signal transduction;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007399,biological_process nervous system development;GO:0008283,biological_process cell proliferation;GO:0010508,biological_process positive regulation of autophagy;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010837,biological_process regulation of keratinocyte proliferation;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030154,biological_process cell differentiation;GO:0031647,biological_process regulation of protein stability;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034599,biological_process cellular response to oxidative stress;GO:0035556,biological_process intracellular signal transduction;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0038033,biological_process positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087,biological_process innate immune response;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045806,biological_process negative regulation of endocytosis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048193,biological_process Golgi vesicle transport;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0060548,biological_process negative regulation of cell death;GO:0071447,biological_process cellular response to hydroperoxide;GO:0089700,biological_process protein kinase D signaling;GO:1901727,biological_process positive regulation of histone deacetylase activity;GO:2001028,biological_process positive regulation of endothelial cell chemotaxis;GO:2001044,biological_process regulation of integrin-mediated signaling pathway	PKD; protein kinase D [EC:2.7.11.13]; K06070	protein kinase D1 [Source:HGNC Symbol%3BAcc:HGNC:9407]
ENSG00000118705	239.05	249.10	241.10	229.95	234.38	222.28	0.0985077246995494	8.94885129432348	0.0942413705572449	0.408669027536649	20:37178409-37241623:+	RPN2	16;GO:0000421,cellular_component autophagosome membrane;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0007568,biological_process aging;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0042493,biological_process response to drug;GO:0043022,molecular_function ribosome binding	SWP1, RPN2; oligosaccharyltransferase complex subunit delta (ribophorin II); K12667	ribophorin II [Source:HGNC Symbol%3BAcc:HGNC:10382]
ENSG00000122694	22.14	24.99	20.38	29.23	26.98	22.72	-0.219466635602298	3.68051968507475	0.0942575868716206	0.408669027536649	9:36136535-36163913:+	GLIPR2	9;GO:0000139,cellular_component Golgi membrane;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade	NA	GLI pathogenesis related 2 [Source:HGNC Symbol%3BAcc:HGNC:18007]
ENSG00000175073	11.54	11.55	11.14	9.78	11.13	10.76	0.122937018280229	5.33686317217649	0.0943520087246584	0.40893557412681	8:66628486-66667217:-	VCPIP1	19;GO:0000278,biological_process mitotic cell cycle;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006508,biological_process proteolysis;GO:0007030,biological_process Golgi organization;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016320,biological_process endoplasmic reticulum membrane fusion;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0090168,biological_process Golgi reassembly	NA	valosin containing protein interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30897]
ENSG00000115687	2.78	3.19	2.56	2.59	2.69	1.99	0.238245326775151	3.44640598551699	0.0944477773889447	0.409068484160028	2:241106098-241150264:-	PASK	20;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0008289,molecular_function lipid binding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043576,biological_process regulation of respiratory gaseous exchange;GO:0045719,biological_process negative regulation of glycogen biosynthetic process;GO:0045727,biological_process positive regulation of translation;GO:0046777,biological_process protein autophosphorylation;GO:0070092,biological_process regulation of glucagon secretion;GO:2000505,biological_process regulation of energy homeostasis	NA	PAS domain containing serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:17270]
ENSG00000166813	1.35	1.34	1.37	1.30	1.14	0.92	0.289372354641964	2.39195668783988	0.0944518269963298	0.409068484160028	15:89608788-89655451:-	KIF7	17;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0097542,cellular_component ciliary tip	NA	kinesin family member 7 [Source:HGNC Symbol%3BAcc:HGNC:30497]
ENSG00000172382	2.11	2.42	3.47	1.81	1.83	2.18	0.469663519543071	1.10682138108355	0.0945015813225251	0.409068484160028	16:2712417-2720551:-	PRSS27	9;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0046658,cellular_component anchored component of plasma membrane	NA	protease%2C serine 27 [Source:HGNC Symbol%3BAcc:HGNC:15475]
ENSG00000108106	149.97	151.41	135.86	156.01	158.84	160.99	-0.111351852955715	6.8430121903436	0.0945144938831032	0.409068484160028	19:55399744-55407777:-	UBE2S	24;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0007049,biological_process cell cycle;GO:0010458,biological_process exit from mitosis;GO:0010994,biological_process free ubiquitin chain polymerization;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035519,biological_process protein K29-linked ubiquitination;GO:0044314,biological_process protein K27-linked ubiquitination;GO:0051301,biological_process cell division;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0085020,biological_process protein K6-linked ubiquitination;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	UBE2S, E2EPF; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]; K10583	ubiquitin conjugating enzyme E2 S [Source:HGNC Symbol%3BAcc:HGNC:17895]
ENSG00000169891	0.32	0.39	0.45	0.79	0.42	0.60	-0.644494792728898	0.1887574373365	0.0946938956201458	0.409702100499432	X:16946690-17153280:+	REPS2	8;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006461,biological_process protein complex assembly;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0061024,biological_process membrane organization	NA	RALBP1 associated Eps domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:9963]
ENSG00000023839	1.40	1.69	1.55	1.32	1.24	1.36	0.240928459909536	2.75448010321694	0.0947476719348199	0.409791934399623	10:99782731-99852192:+	ABCC2	46;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0006979,biological_process response to oxidative stress;GO:0007565,biological_process female pregnancy;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0009408,biological_process response to heat;GO:0009986,cellular_component cell surface;GO:0015127,molecular_function bilirubin transmembrane transporter activity;GO:0015694,biological_process mercury ion transport;GO:0015711,biological_process organic anion transport;GO:0015722,biological_process canalicular bile acid transport;GO:0015723,biological_process bilirubin transport;GO:0015732,biological_process prostaglandin transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016887,molecular_function ATPase activity;GO:0016999,biological_process antibiotic metabolic process;GO:0019904,molecular_function protein domain specific binding;GO:0030644,biological_process cellular chloride ion homeostasis;GO:0031427,biological_process response to methotrexate;GO:0031526,cellular_component brush border membrane;GO:0032870,biological_process cellular response to hormone stimulus;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043225,molecular_function anion transmembrane-transporting ATPase activity;GO:0043627,biological_process response to estrogen;GO:0046581,cellular_component intercellular canaliculus;GO:0046685,biological_process response to arsenic-containing substance;GO:0048545,biological_process response to steroid hormone;GO:0055085,biological_process transmembrane transport;GO:0070327,biological_process thyroid hormone transport;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1;GO:0071354,biological_process cellular response to interleukin-6;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0097327,biological_process response to antineoplastic agent;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport;GO:1901086,biological_process benzylpenicillin metabolic process	ABCC2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; K05666	ATP binding cassette subfamily C member 2 [Source:HGNC Symbol%3BAcc:HGNC:53]
ENSG00000128159	11.40	10.34	11.29	9.95	10.79	10.02	0.117574592731938	5.87919199236176	0.0948223068545785	0.409971889580593	22:50217688-50244992:-	TUBGCP6	22;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000922,cellular_component spindle pole;GO:0000923,cellular_component equatorial microtubule organizing center;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007020,biological_process microtubule nucleation;GO:0008017,molecular_function microtubule binding;GO:0008274,cellular_component gamma-tubulin ring complex;GO:0016020,cellular_component membrane;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0043015,molecular_function gamma-tubulin binding;GO:0051011,molecular_function microtubule minus-end binding;GO:0051298,biological_process centrosome duplication;GO:0051321,biological_process meiotic cell cycle;GO:0051415,biological_process interphase microtubule nucleation by interphase microtubule organizing center;GO:0070062,cellular_component extracellular exosome;GO:0090307,biological_process mitotic spindle assembly	NA	tubulin gamma complex associated protein 6 [Source:HGNC Symbol%3BAcc:HGNC:18127]
ENSG00000198680	17.21	20.13	15.51	13.66	16.69	15.04	0.221429902344446	3.39258463832014	0.094875362012765	0.410043876779628	9:25676388-25678440:-	TUSC1	NA	NA	tumor suppressor candidate 1 [Source:HGNC Symbol%3BAcc:HGNC:31010]
ENSG00000066136	18.41	21.86	20.70	22.70	21.66	23.07	-0.139616141244492	5.10369137727148	0.0949050236033087	0.410043876779628	1:40691647-40771603:+	NFYC	23;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006457,biological_process protein folding;GO:0008134,molecular_function transcription factor binding;GO:0016602,cellular_component CCAAT-binding factor complex;GO:0032993,cellular_component protein-DNA complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0090575,cellular_component RNA polymerase II transcription factor complex	NFYC; nuclear transcription factor Y, gamma; K08066	nuclear transcription factor Y subunit gamma [Source:HGNC Symbol%3BAcc:HGNC:7806]
ENSG00000167258	13.16	13.37	14.65	14.62	14.95	15.36	-0.112943730725862	6.0169444929691	0.0949452797477894	0.410075072202265	17:39461510-39564907:+	CDK12	33;GO:0000166,molecular_function nucleotide binding;GO:0001650,cellular_component fibrillar center;GO:0002944,cellular_component cyclin K-CDK12 complex;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0008134,molecular_function transcription factor binding;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0008380,biological_process RNA splicing;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0019908,cellular_component nuclear cyclin-dependent protein kinase holoenzyme complex;GO:0030332,molecular_function cyclin binding;GO:0043405,biological_process regulation of MAP kinase activity;GO:0043484,biological_process regulation of RNA splicing;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0051726,biological_process regulation of cell cycle;GO:0070816,biological_process phosphorylation of RNA polymerase II C-terminal domain;GO:2000737,biological_process negative regulation of stem cell differentiation	NA	cyclin dependent kinase 12 [Source:HGNC Symbol%3BAcc:HGNC:24224]
ENSG00000173992	36.05	33.78	36.11	32.86	32.23	33.24	0.122182535105863	5.10728518160776	0.0950727820612727	0.410458287655554	11:66592820-66606019:+	CCS	18;GO:0004784,molecular_function superoxide dismutase activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006801,biological_process superoxide metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015680,biological_process intracellular copper ion transport;GO:0016532,molecular_function superoxide dismutase copper chaperone activity;GO:0019430,biological_process removal of superoxide radicals;GO:0030001,biological_process metal ion transport;GO:0034599,biological_process cellular response to oxidative stress;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0051353,biological_process positive regulation of oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	CCS; copper chaperone for superoxide dismutase; K04569	copper chaperone for superoxide dismutase [Source:HGNC Symbol%3BAcc:HGNC:1613]
ENSG00000138675	4.74	6.18	6.65	6.49	6.85	8.41	-0.305568604917908	2.46812089989578	0.0951001397967755	0.410458287655554	4:80266598-80336680:+	FGF5	25;GO:0000165,biological_process MAPK cascade;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005104,molecular_function fibroblast growth factor receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0008083,molecular_function growth factor activity;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010001,biological_process glial cell differentiation;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0023019,biological_process signal transduction involved in regulation of gene expression;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0051781,biological_process positive regulation of cell division	FGF; fibroblast growth factor; K04358	fibroblast growth factor 5 [Source:HGNC Symbol%3BAcc:HGNC:3683]
ENSG00000127884	63.89	63.38	59.64	71.86	65.73	66.44	-0.115337520601432	5.82987274125288	0.0951618454116702	0.410581851614551	10:133362479-133373689:-	ECHS1	11;GO:0003824,molecular_function catalytic activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016829,molecular_function lyase activity;GO:0070062,cellular_component extracellular exosome	ECHS1; enoyl-CoA hydratase [EC:4.2.1.17]; K07511	enoyl-CoA hydratase%2C short chain 1 [Source:HGNC Symbol%3BAcc:HGNC:3151]
ENSG00000157379	30.73	28.19	26.18	25.92	26.42	25.30	0.14555072387761	4.70512304556244	0.0953260002313533	0.410895692752779	14:24290597-24299833:-	DHRS1	6;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	dehydrogenase/reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:16445]
ENSG00000083642	7.21	7.70	7.36	6.38	7.79	5.73	0.173207136990319	4.93610502554664	0.0953374223589511	0.410895692752779	13:32586426-32778019:+	PDS5B	17;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0042127,biological_process regulation of cell proliferation;GO:0051301,biological_process cell division	NA	PDS5 cohesin associated factor B [Source:HGNC Symbol%3BAcc:HGNC:20418]
ENSG00000198796	14.33	14.40	13.99	15.17	16.90	14.67	-0.118161681033118	6.60401667451362	0.0954219934565672	0.410895692752779	18:58481246-58628957:-	ALPK2	7;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	alpha kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:20565]
ENSG00000141756	251.46	229.03	252.74	238.39	210.23	233.96	0.115330553411028	8.83203049517285	0.09542821991911	0.410895692752779	17:41812679-41823217:+	FKBP10	13;GO:0000412,biological_process histone peptidyl-prolyl isomerization;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005509,molecular_function calcium ion binding;GO:0005528,molecular_function FK506 binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0016853,molecular_function isomerase activity;GO:0018208,biological_process peptidyl-proline modification;GO:0046872,molecular_function metal ion binding;GO:0061077,biological_process chaperone-mediated protein folding	NA	FK506 binding protein 10 [Source:HGNC Symbol%3BAcc:HGNC:18169]
ENSG00000145495	81.49	76.66	87.47	75.25	73.56	80.20	0.113556944145244	7.79141799558351	0.0954406447980091	0.410895692752779	5:10353702-10440388:+	MARCH6	21;GO:0000835,cellular_component ER ubiquitin ligase complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008270,molecular_function zinc ion binding;GO:0010498,biological_process proteasomal protein catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0036503,biological_process ERAD pathway;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904380,biological_process endoplasmic reticulum mannose trimming;GO:1990381,molecular_function ubiquitin-specific protease binding	MARCH6, DOA10; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]; K10661	membrane associated ring-CH-type finger 6 [Source:HGNC Symbol%3BAcc:HGNC:30550]
ENSG00000112578	13.68	15.11	13.14	14.50	16.87	15.90	-0.167591878445825	4.30722357611047	0.0954420565495109	0.410895692752779	6:41921187-41933046:+	BYSL	19;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001701,biological_process in utero embryonic development;GO:0001825,biological_process blastocyst formation;GO:0001829,biological_process trophectodermal cell differentiation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0007155,biological_process cell adhesion;GO:0007565,biological_process female pregnancy;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0042254,biological_process ribosome biogenesis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045177,cellular_component apical part of cell	NA	bystin like [Source:HGNC Symbol%3BAcc:HGNC:1157]
ENSG00000116001	57.39	55.48	56.05	49.37	56.14	52.05	0.11304391455911	6.26416482185859	0.0954927481996183	0.410895692752779	2:70209443-70248660:-	TIA1	19;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008143,molecular_function poly(A) binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010494,cellular_component cytoplasmic stress granule;GO:0017091,molecular_function AU-rich element binding;GO:0017148,biological_process negative regulation of translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042036,biological_process negative regulation of cytokine biosynthetic process;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0097165,cellular_component nuclear stress granule;GO:1903608,biological_process protein localization to cytoplasmic stress granule;GO:1904037,biological_process positive regulation of epithelial cell apoptotic process	NA	TIA1 cytotoxic granule associated RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:11802]
ENSG00000153107	12.94	12.81	12.87	14.77	13.83	13.41	-0.109439640077134	6.30391607854546	0.0954994017233359	0.410895692752779	2:111766270-111884690:-	ANAPC1	14;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC1; anaphase-promoting complex subunit 1; K03348	anaphase promoting complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:19988]
ENSG00000166452	44.94	42.39	41.67	40.43	39.80	38.84	0.129100298899974	4.91535560587197	0.0956580295898929	0.411435592965814	11:8911138-8920084:+	AKIP1	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling	NA	A-kinase interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1170]
ENSG00000161647	7.07	7.02	7.37	6.64	6.28	6.24	0.177764023300755	3.65372485911647	0.0957161472104947	0.411497667733071	17:43800798-43833170:-	MPP3	6;GO:0004385,molecular_function guanylate kinase activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0030165,molecular_function PDZ domain binding;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process	NA	membrane palmitoylated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:7221]
ENSG00000160908	10.91	11.58	11.15	9.39	11.04	9.86	0.161155320288542	4.17431769362813	0.095770294168406	0.411497667733071	7:99486518-99500324:-	ZNF394	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 394 [Source:HGNC Symbol%3BAcc:HGNC:18832]
ENSG00000107290	8.00	8.37	8.76	7.23	8.04	8.07	0.117031491334918	6.03897019651561	0.0957719134843181	0.411497667733071	9:132261355-132354985:-	SETX	49;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000228,cellular_component nuclear chromosome;GO:0000781,cellular_component chromosome, telomeric region;GO:0001147,molecular_function transcription termination site sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006376,biological_process mRNA splice site selection;GO:0006396,biological_process RNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0007399,biological_process nervous system development;GO:0007623,biological_process circadian rhythm;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0032508,biological_process DNA duplex unwinding;GO:0033120,biological_process positive regulation of RNA splicing;GO:0034599,biological_process cellular response to oxidative stress;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043491,biological_process protein kinase B signaling;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045171,cellular_component intercellular bridge;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process;GO:0060566,biological_process positive regulation of DNA-templated transcription, termination;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071300,biological_process cellular response to retinoic acid;GO:2000144,biological_process positive regulation of DNA-templated transcription, initiation;GO:2000806,biological_process positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled	NA	senataxin [Source:HGNC Symbol%3BAcc:HGNC:445]
ENSG00000177576	29.43	33.95	27.44	38.09	35.93	33.62	-0.243650318586504	2.94128151985652	0.0958494748101065	0.411688418968115	18:49477249-49487252:-	C18orf32	3;GO:0004871,molecular_function signal transducer activity;GO:0007165,biological_process signal transduction;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling	NA	chromosome 18 open reading frame 32 [Source:HGNC Symbol%3BAcc:HGNC:31690]
ENSG00000075785	263.40	288.70	273.31	253.91	265.75	252.62	0.106740587604682	7.37118371829868	0.0958844134997919	0.411696030706647	3:128726121-128814796:+	RAB7A	61;GO:0000045,biological_process autophagosome assembly;GO:0000166,molecular_function nucleotide binding;GO:0000421,cellular_component autophagosome membrane;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006622,biological_process protein targeting to lysosome;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0007174,biological_process epidermal growth factor catabolic process;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008333,biological_process endosome to lysosome transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0019003,molecular_function GDP binding;GO:0019076,biological_process viral release from host cell;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0022615,biological_process protein to membrane docking;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030904,cellular_component retromer complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0032419,cellular_component extrinsic component of lysosome membrane;GO:0033162,cellular_component melanosome membrane;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043195,cellular_component terminal bouton;GO:0043312,biological_process neutrophil degranulation;GO:0045022,biological_process early endosome to late endosome transport;GO:0045335,cellular_component phagocytic vesicle;GO:0045453,biological_process bone resorption;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0048365,molecular_function Rac GTPase binding;GO:0048524,biological_process positive regulation of viral process;GO:0061024,biological_process membrane organization;GO:0061724,biological_process lipophagy;GO:0070062,cellular_component extracellular exosome;GO:0090382,biological_process phagosome maturation;GO:0090383,biological_process phagosome acidification;GO:0090385,biological_process phagosome-lysosome fusion;GO:0097208,cellular_component alveolar lamellar body;GO:1902583,biological_process multi-organism intracellular transport;GO:1903542,biological_process negative regulation of exosomal secretion;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1905366,biological_process negative regulation of intralumenal vesicle formation;GO:1905394,molecular_function retromer complex binding	RAB7A; Ras-related protein Rab-7A; K07897	RAB7A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9788]
ENSG00000099822	1.11	0.93	1.41	0.90	0.43	1.16	0.487104722759719	1.49064293702319	0.095957261267669	0.411866349970808	19:589892-617159:+	HCN2	32;GO:0000166,molecular_function nucleotide binding;GO:0005216,molecular_function ion channel activity;GO:0005222,molecular_function intracellular cAMP activated cation channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005248,molecular_function voltage-gated sodium channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0007267,biological_process cell-cell signaling;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030552,molecular_function cAMP binding;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0042802,molecular_function identical protein binding;GO:0055085,biological_process transmembrane transport;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0071320,biological_process cellular response to cAMP;GO:0071321,biological_process cellular response to cGMP;GO:0071805,biological_process potassium ion transmembrane transport;GO:0086012,biological_process membrane depolarization during cardiac muscle cell action potential;GO:0098719,biological_process sodium ion import across plasma membrane;GO:0098855,cellular_component HCN channel complex;GO:1990573,biological_process potassium ion import across plasma membrane	HCN2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; K04955	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 [Source:HGNC Symbol%3BAcc:HGNC:4846]
ENSG00000116191	10.72	11.57	9.32	12.20	11.47	11.97	-0.168233553064452	4.33835659968226	0.0960073753466374	0.411939008011687	1:178725146-178921841:+	RALGPS2	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0032485,biological_process regulation of Ral protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	Ral GEF with PH domain and SH3 binding motif 2 [Source:HGNC Symbol%3BAcc:HGNC:30279]
ENSG00000010704	18.08	18.90	17.14	16.26	17.31	15.21	0.15917751755649	4.22268772289002	0.096109550328199	0.412234916456094	6:26087280-26098343:+	HFE	55;GO:0002626,biological_process negative regulation of T cell antigen processing and presentation;GO:0002725,biological_process negative regulation of T cell cytokine production;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006953,biological_process acute-phase response;GO:0007565,biological_process female pregnancy;GO:0009897,cellular_component external side of plasma membrane;GO:0010039,biological_process response to iron ion;GO:0010106,biological_process cellular response to iron ion starvation;GO:0010628,biological_process positive regulation of gene expression;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030509,biological_process BMP signaling pathway;GO:0030881,molecular_function beta-2-microglobulin binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032092,biological_process positive regulation of protein binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033572,biological_process transferrin transport;GO:0039706,molecular_function co-receptor binding;GO:0042446,biological_process hormone biosynthetic process;GO:0045177,cellular_component apical part of cell;GO:0045178,cellular_component basal part of cell;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0055072,biological_process iron ion homeostasis;GO:0060586,biological_process multicellular organismal iron ion homeostasis;GO:0071281,biological_process cellular response to iron ion;GO:0090277,biological_process positive regulation of peptide hormone secretion;GO:0097421,biological_process liver regeneration;GO:0098711,biological_process iron ion import across plasma membrane;GO:1900121,biological_process negative regulation of receptor binding;GO:1900122,biological_process positive regulation of receptor binding;GO:1904283,biological_process negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:1904434,biological_process positive regulation of ferrous iron binding;GO:1904437,biological_process positive regulation of transferrin receptor binding;GO:1904440,biological_process positive regulation of ferrous iron import across plasma membrane;GO:1990357,cellular_component terminal web;GO:1990459,molecular_function transferrin receptor binding;GO:1990641,biological_process response to iron ion starvation;GO:1990712,cellular_component HFE-transferrin receptor complex;GO:2000008,biological_process regulation of protein localization to cell surface;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000272,biological_process negative regulation of receptor activity;GO:2000273,biological_process positive regulation of receptor activity;GO:2001186,biological_process negative regulation of CD8-positive, alpha-beta T cell activation	NA	hemochromatosis [Source:HGNC Symbol%3BAcc:HGNC:4886]
ENSG00000079482	6.69	7.67	7.34	5.66	6.62	7.01	0.174544383219199	4.04936413560066	0.0961806150734208	0.412312056461517	X:68042343-68433913:-	OPHN1	26;GO:0003779,molecular_function actin binding;GO:0005096,molecular_function GTPase activator activity;GO:0005543,molecular_function phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0006930,biological_process substrate-dependent cell migration, cell extension;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0015629,cellular_component actin cytoskeleton;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030100,biological_process regulation of endocytosis;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0042995,cellular_component cell projection;GO:0043195,cellular_component terminal bouton;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:1901799,biological_process negative regulation of proteasomal protein catabolic process	NA	oligophrenin 1 [Source:HGNC Symbol%3BAcc:HGNC:8148]
ENSG00000147416	50.18	53.99	49.53	47.84	48.64	47.11	0.107819305220147	6.35384653307006	0.0961939672530857	0.412312056461517	8:20197366-20226819:+	ATP6V1B2	30;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0012505,cellular_component endomembrane system;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0016820,molecular_function hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;GO:0033180,cellular_component proton-transporting V-type ATPase, V1 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0042470,cellular_component melanosome;GO:0043209,cellular_component myelin sheath;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046034,biological_process ATP metabolic process;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV1B, ATP6B; V-type H+-transporting ATPase subunit B; K02147	ATPase H+ transporting V1 subunit B2 [Source:HGNC Symbol%3BAcc:HGNC:854]
ENSG00000136883	70.19	62.11	76.66	60.66	63.98	67.83	0.131959309819195	7.13167630560978	0.096254332563094	0.412428384572208	9:114086125-114099291:-	KIF12	15;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008150,biological_process biological_process;GO:0016887,molecular_function ATPase activity;GO:0070062,cellular_component extracellular exosome	NA	kinesin family member 12 [Source:HGNC Symbol%3BAcc:HGNC:21495]
ENSG00000109674	8.05	8.53	8.03	10.64	9.28	8.29	-0.186426973442831	4.01193142333346	0.0963895650943161	0.412792402172138	4:177309835-177362943:+	NEIL3	22;GO:0000405,molecular_function bubble DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003824,molecular_function catalytic activity;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016799,molecular_function hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0016829,molecular_function lyase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0046872,molecular_function metal ion binding	NEIL3; endonuclease VIII-like 3; K10569	nei like DNA glycosylase 3 [Source:HGNC Symbol%3BAcc:HGNC:24573]
ENSG00000170525	56.83	55.54	59.37	60.25	63.00	62.95	-0.104145543800095	6.98578445289383	0.0964057982677054	0.412792402172138	10:6144933-6254644:+	PFKFB3	18;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003873,molecular_function 6-phosphofructo-2-kinase activity;GO:0004331,molecular_function fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006000,biological_process fructose metabolic process;GO:0006003,biological_process fructose 2,6-bisphosphate metabolic process;GO:0007420,biological_process brain development;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0045821,biological_process positive regulation of glycolytic process;GO:0046835,biological_process carbohydrate phosphorylation	PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]; K01103	6-phosphofructo-2-kinase/fructose-2%2C6-biphosphatase 3 [Source:HGNC Symbol%3BAcc:HGNC:8874]
ENSG00000165782	35.39	35.28	41.23	30.16	38.01	32.55	0.166324635732519	4.94419164167297	0.0964785787626247	0.412961585579469	14:20457718-20461612:-	TMEM55B	11;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006644,biological_process phospholipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031902,cellular_component late endosome membrane;GO:0034597,molecular_function phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity;GO:0046856,biological_process phosphatidylinositol dephosphorylation	TMEM55; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]; K13084	transmembrane protein 55B [Source:HGNC Symbol%3BAcc:HGNC:19299]
ENSG00000163950	60.91	63.27	64.13	67.86	67.22	69.13	-0.10603523609668	6.04043843073582	0.0965182100297072	0.412988811133663	4:1692799-1712555:-	SLBP	20;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006398,biological_process mRNA 3'-end processing by stem-loop binding and cleavage;GO:0006406,biological_process mRNA export from nucleus;GO:0008334,biological_process histone mRNA metabolic process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033260,biological_process nuclear DNA replication;GO:0044770,biological_process cell cycle phase transition;GO:0051028,biological_process mRNA transport;GO:0071204,cellular_component histone pre-mRNA 3'end processing complex;GO:0071207,molecular_function histone pre-mRNA stem-loop binding;GO:0071208,molecular_function histone pre-mRNA DCP binding	NA	stem-loop binding protein [Source:HGNC Symbol%3BAcc:HGNC:10904]
ENSG00000004700	39.03	42.90	40.75	36.72	36.19	40.99	0.116345509084554	6.26521307506571	0.0966490213335663	0.413406030948848	12:21468910-21501669:-	RECQL	23;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000733,biological_process DNA strand renaturation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0009378,molecular_function four-way junction helicase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0036310,molecular_function annealing helicase activity;GO:0043140,molecular_function ATP-dependent 3'-5' DNA helicase activity	NA	RecQ like helicase [Source:HGNC Symbol%3BAcc:HGNC:9948]
ENSG00000143545	260.35	278.85	264.19	244.78	265.26	240.05	0.110095569714146	7.30263087687991	0.0967930682383698	0.413879557713704	1:153981616-153986358:-	RAB13	41;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006810,biological_process transport;GO:0010737,biological_process protein kinase A signaling;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016328,cellular_component lateral plasma membrane;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031175,biological_process neuron projection development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032456,biological_process endocytic recycling;GO:0032593,cellular_component insulin-responsive compartment;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0035767,biological_process endothelial cell chemotaxis;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043687,biological_process post-translational protein modification;GO:0044795,biological_process trans-Golgi network to recycling endosome transport;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly;GO:0072659,biological_process protein localization to plasma membrane;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0097368,biological_process establishment of Sertoli cell barrier;GO:1902463,biological_process protein localization to cell leading edge	RAB13; Ras-related protein Rab-13; K06109	RAB13%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9762]
ENSG00000099849	32.35	28.69	29.47	30.10	25.92	26.96	0.140252444183297	5.09926832792381	0.0968973211554229	0.414182660985628	11:560403-564021:+	RASSF7	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0070507,biological_process regulation of microtubule cytoskeleton organization	NA	Ras association domain family member 7 [Source:HGNC Symbol%3BAcc:HGNC:1166]
ENSG00000116711	1.48	1.53	1.64	1.03	1.69	0.78	0.425261108340625	1.67020241899056	0.0970455806107721	0.414673594534084	1:186828952-186988981:+	PLA2G4A	36;GO:0004620,molecular_function phospholipase activity;GO:0004622,molecular_function lysophospholipase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006663,biological_process platelet activating factor biosynthetic process;GO:0006690,biological_process icosanoid metabolic process;GO:0008152,biological_process metabolic process;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0009395,biological_process phospholipid catabolic process;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035965,biological_process cardiolipin acyl-chain remodeling;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0036149,biological_process phosphatidylinositol acyl-chain remodeling;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0042127,biological_process regulation of cell proliferation;GO:0046456,biological_process icosanoid biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0047498,molecular_function calcium-dependent phospholipase A2 activity;GO:0050482,biological_process arachidonic acid secretion;GO:0071236,biological_process cellular response to antibiotic	PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]; K16342	phospholipase A2 group IVA [Source:HGNC Symbol%3BAcc:HGNC:9035]
ENSG00000164877	8.07	9.35	9.98	8.72	7.64	8.27	0.162436448439532	4.57252463144734	0.0971468589565542	0.414826487252678	7:1428464-1459502:-	MICALL2	27;GO:0001725,cellular_component stress fiber;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030041,biological_process actin filament polymerization;GO:0030054,cellular_component cell junction;GO:0031005,molecular_function filamin binding;GO:0031175,biological_process neuron projection development;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0032432,cellular_component actin filament bundle;GO:0032456,biological_process endocytic recycling;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042805,molecular_function actinin binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0055037,cellular_component recycling endosome;GO:0070830,biological_process bicellular tight junction assembly;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	MICAL like 2 [Source:HGNC Symbol%3BAcc:HGNC:29672]
ENSG00000198346	2.58	2.80	2.27	2.70	2.81	4.05	-0.319222796105524	2.52258716109063	0.0971481993429094	0.414826487252678	19:53467734-53496255:+	ZNF813	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 813 [Source:HGNC Symbol%3BAcc:HGNC:33257]
ENSG00000146856	1.92	1.42	1.48	0.95	1.34	1.54	0.349413320263151	2.08855007359872	0.0972663624712013	0.415188224675042	7:134986507-135147963:+	AGBL3	11;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0035610,biological_process protein side chain deglutamylation;GO:0046872,molecular_function metal ion binding	NA	ATP/GTP binding protein like 3 [Source:HGNC Symbol%3BAcc:HGNC:27981]
ENSG00000158006	6.46	6.26	7.79	9.05	8.34	7.08	-0.235554603951306	3.18804486204187	0.0974126460073204	0.41565864433907	1:25959766-25998157:-	PAFAH2	9;GO:0003847,molecular_function 1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0005543,molecular_function phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0007596,biological_process blood coagulation;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0043066,biological_process negative regulation of apoptotic process	PLA2G7, PAFAH; platelet-activating factor acetylhydrolase [EC:3.1.1.47]; K01062	platelet activating factor acetylhydrolase 2 [Source:HGNC Symbol%3BAcc:HGNC:8579]
ENSG00000213401	1.80	1.12	1.41	0.87	1.13	0.97	0.574766545611838	0.383396449809167	0.0974435394366144	0.41565864433907	X:152733778-152737669:+	MAGEA12	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	MAGE family member A12 [Source:HGNC Symbol%3BAcc:HGNC:6799]
ENSG00000130338	3.72	3.61	4.52	4.38	4.39	4.68	-0.16655309468157	4.30338388782311	0.0975139447189059	0.415816075505249	6:158232235-158511828:+	TULP4	9;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0016567,biological_process protein ubiquitination;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification;GO:0061512,biological_process protein localization to cilium	NA	tubby like protein 4 [Source:HGNC Symbol%3BAcc:HGNC:15530]
ENSG00000131473	151.60	154.13	147.27	144.17	142.06	141.36	0.0948489568819721	8.92259245231589	0.0977708647320876	0.416647227271831	17:41866907-41930542:-	ACLY	31;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003878,molecular_function ATP citrate synthase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006085,biological_process acetyl-CoA biosynthetic process;GO:0006101,biological_process citrate metabolic process;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0009346,cellular_component citrate lyase complex;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016829,molecular_function lyase activity;GO:0031325,biological_process positive regulation of cellular metabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0046912,molecular_function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0048037,molecular_function cofactor binding;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	ACLY; ATP citrate (pro-S)-lyase [EC:2.3.3.8]; K01648	ATP citrate lyase [Source:HGNC Symbol%3BAcc:HGNC:115]
ENSG00000169379	10.30	11.55	11.78	12.67	12.51	12.65	-0.162438220675959	4.07986739043349	0.0977800778593751	0.416647227271831	3:93980138-94055668:+	ARL13B	23;GO:0000166,molecular_function nucleotide binding;GO:0001947,biological_process heart looping;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007224,biological_process smoothened signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007368,biological_process determination of left/right symmetry;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010226,biological_process response to lithium ion;GO:0016020,cellular_component membrane;GO:0021532,biological_process neural tube patterning;GO:0021830,biological_process interneuron migration from the subpallium to the cortex;GO:0021943,biological_process formation of radial glial scaffolds;GO:0031514,cellular_component motile cilium;GO:0042995,cellular_component cell projection;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0070986,biological_process left/right axis specification;GO:1905515,biological_process non-motile cilium assembly	NA	ADP ribosylation factor like GTPase 13B [Source:HGNC Symbol%3BAcc:HGNC:25419]
ENSG00000083520	12.12	11.60	12.46	10.79	11.09	11.66	0.122945040013381	5.10303075411856	0.0978095561322899	0.416647227271831	13:72752168-72782096:-	DIS3	23;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0016075,biological_process rRNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0043488,biological_process regulation of mRNA stability;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0071034,biological_process CUT catabolic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	DIS3, RRP44; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]; K12585	DIS3 homolog%2C exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol%3BAcc:HGNC:20604]
ENSG00000173156	2.69	1.97	2.10	3.33	2.53	3.57	-0.452535543541815	0.905563243044051	0.097875299712021	0.416784252255683	11:67056817-67072013:+	RHOD	22;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006605,biological_process protein targeting;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030032,biological_process lamellipodium assembly;GO:0030335,biological_process positive regulation of cell migration;GO:0045785,biological_process positive regulation of cell adhesion;GO:0048041,biological_process focal adhesion assembly;GO:0051017,biological_process actin filament bundle assembly;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051893,biological_process regulation of focal adhesion assembly;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	RHOD; Ras homolog gene family, member D; K07530	ras homolog family member D [Source:HGNC Symbol%3BAcc:HGNC:670]
ENSG00000165650	18.50	15.71	18.26	15.94	16.52	16.23	0.124383952194273	5.87335463285997	0.0980072171747848	0.417202876128465	10:117277273-117375467:-	PDZD8	7;GO:0005622,cellular_component intracellular;GO:0007010,biological_process cytoskeleton organization;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0022604,biological_process regulation of cell morphogenesis;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	PDZ domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:26974]
ENSG00000113068	108.72	99.77	104.10	105.03	118.68	119.80	-0.122127796093538	5.56915371255991	0.0980772679682812	0.417357945591455	5:140245038-140303121:-	PFDN1	9;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006457,biological_process protein folding;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0016272,cellular_component prefoldin complex;GO:0044183,molecular_function protein binding involved in protein folding;GO:0051082,molecular_function unfolded protein binding	NA	prefoldin subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:8866]
ENSG00000158373	21.30	13.15	19.86	15.65	13.64	15.44	0.309360696168373	2.68893291695071	0.0981987224692263	0.417731577111209	6:26158145-26171349:+	HIST1H2BD	11;GO:0000786,cellular_component nucleosome;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006334,biological_process nucleosome assembly;GO:0016567,biological_process protein ubiquitination;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome	H2B; histone H2B; K11252	histone cluster 1 H2B family member d [Source:HGNC Symbol%3BAcc:HGNC:4747]
ENSG00000274874	35.22	26.53	32.73	38.30	36.46	34.89	-0.189183453492683	3.75151688204443	0.098235918315152	0.417746644071936	12:123973943-124088594:+	AC068790.8	NA	NA	NA
ENSG00000197965	71.14	73.54	71.36	65.38	71.96	63.63	0.115594173462991	5.83618749268337	0.0982811265545755	0.417795761617105	1:167721191-167791919:+	MPZL1	10;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	MPZ; myelin protein zero; K06770	myelin protein zero like 1 [Source:HGNC Symbol%3BAcc:HGNC:7226]
ENSG00000085721	18.88	16.76	18.68	20.64	19.03	20.16	-0.122826529999551	5.26840389273212	0.0983323873716916	0.417870566396716	16:15060021-15094317:-	RRN3	23;GO:0001042,molecular_function RNA polymerase I core binding;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0001180,biological_process transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript;GO:0001181,molecular_function transcription factor activity, core RNA polymerase I binding;GO:0001701,biological_process in utero embryonic development;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006356,biological_process regulation of transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0007000,biological_process nucleolus organization;GO:0007028,biological_process cytoplasm organization;GO:0008283,biological_process cell proliferation;GO:0010976,biological_process positive regulation of neuron projection development;GO:0042254,biological_process ribosome biogenesis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048872,biological_process homeostasis of number of cells;GO:0070063,molecular_function RNA polymerase binding;GO:1902254,biological_process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:2000142,biological_process regulation of DNA-templated transcription, initiation	NA	RRN3 homolog%2C RNA polymerase I transcription factor [Source:HGNC Symbol%3BAcc:HGNC:30346]
ENSG00000181404	3.54	4.04	3.64	3.11	3.32	2.87	0.275535499306291	2.2914498871602	0.0983994265588185	0.417932141818165	9:14520-29739:-	WASHC1	49;GO:0000145,cellular_component exocyst;GO:0001556,biological_process oocyte maturation;GO:0002468,biological_process dendritic cell antigen processing and presentation;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0007032,biological_process endosome organization;GO:0010507,biological_process negative regulation of autophagy;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0022617,biological_process extracellular matrix disassembly;GO:0030335,biological_process positive regulation of cell migration;GO:0030833,biological_process regulation of actin filament polymerization;GO:0031083,cellular_component BLOC-1 complex;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031901,cellular_component early endosome membrane;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0034394,biological_process protein localization to cell surface;GO:0040038,biological_process polar body extrusion after meiotic divisions;GO:0042098,biological_process T cell proliferation;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043014,molecular_function alpha-tubulin binding;GO:0043015,molecular_function gamma-tubulin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043553,biological_process negative regulation of phosphatidylinositol 3-kinase activity;GO:0050776,biological_process regulation of immune response;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0071203,cellular_component WASH complex;GO:0071437,cellular_component invadopodium;GO:0090306,biological_process spindle assembly involved in meiosis;GO:0099638,biological_process endosome to plasma membrane protein transport;GO:1904109,biological_process positive regulation of cholesterol import;GO:1990126,biological_process retrograde transport, endosome to plasma membrane;GO:2000010,biological_process positive regulation of protein localization to cell surface	NA	WASH complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:24361]
ENSG00000166562	14.69	16.89	15.43	12.85	14.33	13.53	0.211471103925315	3.09606321652797	0.0984193944038852	0.417932141818165	18:59139476-59158836:+	SEC11C	12;GO:0005783,cellular_component endoplasmic reticulum;GO:0005787,cellular_component signal peptidase complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	SEC11, sipW; signal peptidase I [EC:3.4.21.89]; K13280	SEC11 homolog C%2C signal peptidase complex subunit [Source:HGNC Symbol%3BAcc:HGNC:23400]
ENSG00000131876	70.89	66.06	63.48	60.08	64.66	61.70	0.117239353800122	5.69374228606734	0.0984478838859513	0.417932141818165	15:101281509-101295282:-	SNRPA1	16;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0030620,molecular_function U2 snRNA binding;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0071013,cellular_component catalytic step 2 spliceosome	SNRPA1; U2 small nuclear ribonucleoprotein A'; K11092	small nuclear ribonucleoprotein polypeptide A' [Source:HGNC Symbol%3BAcc:HGNC:11152]
ENSG00000149929	11.18	12.20	9.93	11.40	13.46	12.86	-0.17415967736958	4.31375618674391	0.0984963463857169	0.417994922285779	16:29992320-29996436:-	HIRIP3	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006333,biological_process chromatin assembly or disassembly	NA	HIRA interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:4917]
ENSG00000152253	23.65	30.72	22.12	28.75	29.91	29.09	-0.198650238670789	4.20844773768039	0.0985488461965373	0.418074787367607	2:168834131-168913371:-	SPC25	13;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0031262,cellular_component Ndc80 complex;GO:0051301,biological_process cell division	NA	SPC25%2C NDC80 kinetochore complex component [Source:HGNC Symbol%3BAcc:HGNC:24031]
ENSG00000165246	3.16	2.94	2.97	3.46	3.40	3.67	-0.201429448412757	3.17144921202549	0.0986911031388504	0.418535245392057	Y:14522637-14845650:+	NLGN4Y	26;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007158,biological_process neuron cell-cell adhesion;GO:0007612,biological_process learning;GO:0009986,cellular_component cell surface;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0035176,biological_process social behavior;GO:0042043,molecular_function neurexin family protein binding;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0050804,biological_process modulation of synaptic transmission;GO:0050808,biological_process synapse organization;GO:0050839,molecular_function cell adhesion molecule binding;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0071625,biological_process vocalization behavior;GO:0097104,biological_process postsynaptic membrane assembly;GO:0097105,biological_process presynaptic membrane assembly;GO:0097110,molecular_function scaffold protein binding	NLGN; neuroligin; K07378	neuroligin 4%2C Y-linked [Source:HGNC Symbol%3BAcc:HGNC:15529]
ENSG00000102007	266.08	258.17	274.32	306.34	276.56	285.01	-0.107801086915173	7.24736462461237	0.0987915268395737	0.418543693642504	X:49171925-49175239:+	PLP2	13;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006811,biological_process ion transport;GO:0006935,biological_process chemotaxis;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019956,molecular_function chemokine binding;GO:0034220,biological_process ion transmembrane transport;GO:0070062,cellular_component extracellular exosome	NA	proteolipid protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9087]
ENSG00000155657	0.04	0.04	0.06	0.06	0.05	0.07	-0.291794615398114	2.69494553075161	0.09879260961544	0.418543693642504	2:178525988-178830802:-	TTN	56;GO:0000166,molecular_function nucleotide binding;GO:0000794,cellular_component condensed nuclear chromosome;GO:0002020,molecular_function protease binding;GO:0002576,biological_process platelet degranulation;GO:0003300,biological_process cardiac muscle hypertrophy;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005859,cellular_component muscle myosin complex;GO:0006468,biological_process protein phosphorylation;GO:0006936,biological_process muscle contraction;GO:0006941,biological_process striated muscle contraction;GO:0007076,biological_process mitotic chromosome condensation;GO:0008307,molecular_function structural constituent of muscle;GO:0010628,biological_process positive regulation of gene expression;GO:0010737,biological_process protein kinase A signaling;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030018,cellular_component Z disc;GO:0030049,biological_process muscle filament sliding;GO:0030240,biological_process skeletal muscle thin filament assembly;GO:0030241,biological_process skeletal muscle myosin thick filament assembly;GO:0031430,cellular_component M band;GO:0031433,molecular_function telethonin binding;GO:0031674,cellular_component I band;GO:0035995,biological_process detection of muscle stretch;GO:0042802,molecular_function identical protein binding;GO:0042805,molecular_function actinin binding;GO:0043621,molecular_function protein self-association;GO:0045214,biological_process sarcomere organization;GO:0045859,biological_process regulation of protein kinase activity;GO:0046872,molecular_function metal ion binding;GO:0048739,biological_process cardiac muscle fiber development;GO:0048769,biological_process sarcomerogenesis;GO:0050714,biological_process positive regulation of protein secretion;GO:0050790,biological_process regulation of catalytic activity;GO:0051015,molecular_function actin filament binding;GO:0051371,molecular_function muscle alpha-actinin binding;GO:0051592,biological_process response to calcium ion;GO:0055003,biological_process cardiac myofibril assembly;GO:0055008,biological_process cardiac muscle tissue morphogenesis;GO:0060048,biological_process cardiac muscle contraction;GO:0070062,cellular_component extracellular exosome;GO:0097493,molecular_function structural molecule activity conferring elasticity	TTN; titin [EC:2.7.11.1]; K12567	titin [Source:HGNC Symbol%3BAcc:HGNC:12403]
ENSG00000172888	8.67	7.70	9.09	10.80	8.02	11.23	-0.223212433871427	3.67086384177774	0.0987942497681894	0.418543693642504	3:40524877-40574685:+	ZNF621	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 621 [Source:HGNC Symbol%3BAcc:HGNC:24787]
ENSG00000123349	242.89	232.33	215.51	214.30	215.11	216.15	0.109186583666548	6.80459003604704	0.0988817923372753	0.418771643903991	12:53295290-53299450:+	PFDN5	11;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006457,biological_process protein folding;GO:0016272,cellular_component prefoldin complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051082,molecular_function unfolded protein binding;GO:0060041,biological_process retina development in camera-type eye;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	prefoldin subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:8869]
ENSG00000070444	12.34	12.21	12.60	11.71	11.21	11.04	0.143074171544982	4.38124083236238	0.0989998940262759	0.419128814648077	17:2384059-2401118:-	MNT	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007569,biological_process cell aging;GO:0008285,biological_process negative regulation of cell proliferation;GO:0046983,molecular_function protein dimerization activity;GO:0051726,biological_process regulation of cell cycle;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	NA	MAX network transcriptional repressor [Source:HGNC Symbol%3BAcc:HGNC:7188]
ENSG00000167548	7.15	6.85	7.16	7.59	7.88	7.45	-0.102965491447588	6.93861746053211	0.0991124856162942	0.419462422078097	12:49018974-49059774:-	KMT2D	26;GO:0001555,biological_process oocyte growth;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006342,biological_process chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0043627,biological_process response to estrogen;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044666,cellular_component MLL3/4 complex;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048477,biological_process oogenesis;GO:0051568,biological_process histone H3-K4 methylation;GO:1904837,biological_process beta-catenin-TCF complex assembly	MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]; K09187	lysine methyltransferase 2D [Source:HGNC Symbol%3BAcc:HGNC:7133]
ENSG00000165471	1.99	2.31	1.78	1.01	1.94	1.23	0.543376297168467	0.492577663003986	0.0991579563588205	0.41951183104364	10:52765379-52771700:-	MBL2	26;GO:0001867,biological_process complement activation, lectin pathway;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005537,molecular_function mannose binding;GO:0005576,cellular_component extracellular region;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006953,biological_process acute-phase response;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0006979,biological_process response to oxidative stress;GO:0008228,biological_process opsonization;GO:0009986,cellular_component cell surface;GO:0030246,molecular_function carbohydrate binding;GO:0042742,biological_process defense response to bacterium;GO:0044130,biological_process negative regulation of growth of symbiont in host;GO:0045087,biological_process innate immune response;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048525,biological_process negative regulation of viral process;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051873,biological_process killing by host of symbiont cells	MBL; mannose-binding lectin; K03991	mannose binding lectin 2 [Source:HGNC Symbol%3BAcc:HGNC:6922]
ENSG00000104613	18.19	19.47	17.41	17.71	16.25	16.94	0.121418812857867	5.34013535026093	0.0992133906914615	0.419603345367329	8:19817139-19852083:+	INTS10	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016180,biological_process snRNA processing;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 10 [Source:HGNC Symbol%3BAcc:HGNC:25548]
ENSG00000112379	0.54	0.50	0.50	0.80	0.62	0.54	-0.332020805603478	1.98684697736984	0.0993983138652165	0.420033406383338	6:138161920-138344663:+	ARFGEF3	11;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0030658,cellular_component transport vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	ARFGEF family member 3 [Source:HGNC Symbol%3BAcc:HGNC:21213]
ENSG00000185499	3.36	3.28	4.48	2.92	3.75	2.82	0.247311899184121	3.74073414960254	0.0994219464198887	0.420033406383338	1:155185823-155192916:-	MUC1	32;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0002039,molecular_function p53 binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007565,biological_process female pregnancy;GO:0010944,biological_process negative regulation of transcription by competitive promoter binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016324,cellular_component apical plasma membrane;GO:0030855,biological_process epithelial cell differentiation;GO:0031982,cellular_component vesicle;GO:0033629,biological_process negative regulation of cell adhesion mediated by integrin;GO:0036003,biological_process positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0043618,biological_process regulation of transcription from RNA polymerase II promoter in response to stress;GO:0070062,cellular_component extracellular exosome;GO:0071300,biological_process cellular response to retinoic acid;GO:0090240,biological_process positive regulation of histone H4 acetylation;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	NA	mucin 1%2C cell surface associated [Source:HGNC Symbol%3BAcc:HGNC:7508]
ENSG00000167967	10.02	8.83	9.54	8.58	8.30	9.06	0.1468483920461	4.52562548351898	0.0994358454324543	0.420033406383338	16:2223565-2235742:+	E4F1	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0009794,biological_process regulation of mitotic cell cycle, embryonic;GO:0010564,biological_process regulation of cell cycle process;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0035497,molecular_function cAMP response element binding;GO:0040008,biological_process regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0071850,biological_process mitotic cell cycle arrest	NA	E4F transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:3121]
ENSG00000135862	168.76	171.49	170.59	158.68	162.53	162.18	0.0914703498101806	9.64494413873152	0.0994811303840607	0.420033406383338	1:183023459-183145592:+	LAMC1	24;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005606,cellular_component laminin-1 complex;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006461,biological_process protein complex assembly;GO:0007155,biological_process cell adhesion;GO:0007492,biological_process endoderm development;GO:0016477,biological_process cell migration;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0031581,biological_process hemidesmosome assembly;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0043259,cellular_component laminin-10 complex;GO:0043260,cellular_component laminin-11 complex;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048731,biological_process system development;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070831,biological_process basement membrane assembly	LAMC1; laminin, gamma 1; K05635	laminin subunit gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:6492]
ENSG00000146425	261.66	270.46	269.39	288.10	284.78	292.34	-0.0990609898432267	7.28109459044775	0.0995490539029447	0.420033406383338	6:158636473-158644739:-	DYNLT1	32;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016032,biological_process viral process;GO:0019060,biological_process intracellular transport of viral protein in host cell;GO:0030286,cellular_component dynein complex;GO:0034774,cellular_component secretory granule lumen;GO:0042802,molecular_function identical protein binding;GO:0043087,biological_process regulation of GTPase activity;GO:0043312,biological_process neutrophil degranulation;GO:0043657,cellular_component host cell;GO:0046718,biological_process viral entry into host cell;GO:0048812,biological_process neuron projection morphogenesis;GO:0050768,biological_process negative regulation of neurogenesis;GO:0051301,biological_process cell division;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0075521,biological_process microtubule-dependent intracellular transport of viral material towards nucleus;GO:0075606,biological_process transport of viral material towards nucleus;GO:0099503,cellular_component secretory vesicle;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	dynein light chain Tctex-type 1 [Source:HGNC Symbol%3BAcc:HGNC:11697]
ENSG00000135775	14.74	14.88	16.00	13.36	15.00	13.69	0.130946916011295	5.06864026420863	0.0995807524575412	0.420033406383338	1:230642488-230693982:+	COG2	15;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032403,molecular_function protein complex binding;GO:0032588,cellular_component trans-Golgi network membrane	NA	component of oligomeric golgi complex 2 [Source:HGNC Symbol%3BAcc:HGNC:6546]
ENSG00000132002	73.85	84.52	71.03	67.89	72.68	71.41	0.122239457168907	6.24516273355276	0.09960169851035	0.420033406383338	19:14514769-14529770:-	DNAJB1	22;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006986,biological_process response to unfolded protein;GO:0030544,molecular_function Hsp70 protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0045296,molecular_function cadherin binding;GO:0051082,molecular_function unfolded protein binding;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051087,molecular_function chaperone binding;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:0070389,biological_process chaperone cofactor-dependent protein refolding;GO:0090084,biological_process negative regulation of inclusion body assembly;GO:0097201,biological_process negative regulation of transcription from RNA polymerase II promoter in response to stress;GO:1900034,biological_process regulation of cellular response to heat	DNAJB1; DnaJ homolog subfamily B member 1; K09507	DnaJ heat shock protein family (Hsp40) member B1 [Source:HGNC Symbol%3BAcc:HGNC:5270]
ENSG00000074416	99.76	107.93	109.19	97.40	97.77	101.35	0.106692740373513	6.92043831868958	0.0996427161958482	0.420033406383338	3:127689061-127823250:-	MGLL	25;GO:0004622,molecular_function lysophospholipase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006954,biological_process inflammatory response;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0019433,biological_process triglyceride catabolic process;GO:0019898,cellular_component extrinsic component of membrane;GO:0036155,biological_process acylglycerol acyl-chain remodeling;GO:0042803,molecular_function protein homodimerization activity;GO:0046464,biological_process acylglycerol catabolic process;GO:0047372,molecular_function acylglycerol lipase activity;GO:0050727,biological_process regulation of inflammatory response;GO:0051930,biological_process regulation of sensory perception of pain;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:2000124,biological_process regulation of endocannabinoid signaling pathway	MGLL; acylglycerol lipase [EC:3.1.1.23]; K01054	monoglyceride lipase [Source:HGNC Symbol%3BAcc:HGNC:17038]
ENSG00000178971	6.02	6.99	5.56	5.68	5.53	5.45	0.160097241813144	4.42669988730797	0.0996462508442213	0.420033406383338	17:8224820-8248044:-	CTC1	26;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007568,biological_process aging;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010833,biological_process telomere maintenance via telomere lengthening;GO:0016233,biological_process telomere capping;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0035264,biological_process multicellular organism growth;GO:0042162,molecular_function telomeric DNA binding;GO:0045740,biological_process positive regulation of DNA replication;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0048539,biological_process bone marrow development;GO:0051276,biological_process chromosome organization;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:0090399,biological_process replicative senescence;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1990879,cellular_component CST complex	NA	CST telomere replication complex component 1 [Source:HGNC Symbol%3BAcc:HGNC:26169]
ENSG00000204590	50.58	48.24	52.32	57.82	53.03	53.78	-0.110327994532952	6.63845641738975	0.0996605836910303	0.420033406383338	6:30541376-30557174:-	GNL1	10;GO:0000166,molecular_function nucleotide binding;GO:0002456,biological_process T cell mediated immunity;GO:0003924,molecular_function GTPase activity;GO:0005198,molecular_function structural molecule activity;GO:0005525,molecular_function GTP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007165,biological_process signal transduction;GO:0042254,biological_process ribosome biogenesis	NA	G protein nucleolar 1 (putative) [Source:HGNC Symbol%3BAcc:HGNC:4413]
ENSG00000169992	23.43	24.45	22.77	20.71	22.50	22.65	0.110757077885932	5.83630023510266	0.0997060312039488	0.420033406383338	17:7404873-7419860:+	NLGN2	44;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0004872,molecular_function receptor activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007158,biological_process neuron cell-cell adhesion;GO:0007416,biological_process synapse assembly;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019233,biological_process sensory perception of pain;GO:0030054,cellular_component cell junction;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032230,biological_process positive regulation of synaptic transmission, GABAergic;GO:0035418,biological_process protein localization to synapse;GO:0035641,biological_process locomotory exploration behavior;GO:0042043,molecular_function neurexin family protein binding;GO:0042734,cellular_component presynaptic membrane;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045217,biological_process cell-cell junction maintenance;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0050804,biological_process modulation of synaptic transmission;GO:0050808,biological_process synapse organization;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051965,biological_process positive regulation of synapse assembly;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0060077,cellular_component inhibitory synapse;GO:0072553,biological_process terminal button organization;GO:0097104,biological_process postsynaptic membrane assembly;GO:0097105,biological_process presynaptic membrane assembly;GO:0097116,biological_process gephyrin clustering involved in postsynaptic density assembly;GO:0097119,biological_process postsynaptic density protein 95 clustering;GO:0097151,biological_process positive regulation of inhibitory postsynaptic potential;GO:0099055,cellular_component integral component of postsynaptic membrane;GO:1902474,biological_process positive regulation of protein localization to synapse;GO:1904862,biological_process inhibitory synapse assembly;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000809,biological_process positive regulation of synaptic vesicle clustering	NLGN; neuroligin; K07378	neuroligin 2 [Source:HGNC Symbol%3BAcc:HGNC:14290]
ENSG00000125447	18.58	15.42	16.81	15.60	15.13	16.14	0.1327651444963	5.40956747474736	0.0997211349884555	0.420033406383338	17:75236598-75262363:-	GGA3	18;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030131,cellular_component clathrin adaptor complex;GO:0030306,molecular_function ADP-ribosylation factor binding;GO:0031901,cellular_component early endosome membrane;GO:0044267,biological_process cellular protein metabolic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization	GGA; ADP-ribosylation factor-binding protein GGA; K12404	golgi associated%2C gamma adaptin ear containing%2C ARF binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:17079]
ENSG00000198142	4.53	5.89	5.09	6.18	5.73	6.21	-0.22709556842729	3.16383288787035	0.0997717185011279	0.420103915113467	2:109614333-109618990:+	SOWAHC	NA	NA	sosondowah ankyrin repeat domain family member C [Source:HGNC Symbol%3BAcc:HGNC:26149]
ENSG00000109689	3.57	3.77	4.19	4.57	4.53	4.26	-0.197716337405316	3.40398656242324	0.0999269494932775	0.420543948794733	4:26857677-27025381:+	STIM2	18;GO:0002115,biological_process store-operated calcium entry;GO:0005246,molecular_function calcium channel regulator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0015279,molecular_function store-operated calcium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032237,biological_process activation of store-operated calcium channel activity;GO:0046872,molecular_function metal ion binding;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0070588,biological_process calcium ion transmembrane transport	STIM1; stromal interaction molecule 1; K16059	stromal interaction molecule 2 [Source:HGNC Symbol%3BAcc:HGNC:19205]
ENSG00000125337	1.04	0.58	1.33	0.65	0.33	0.91	0.674435102637836	0.139338196711248	0.0999939529939718	0.420543948794733	6:167996240-168045089:+	KIF25	20;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000166,molecular_function nucleotide binding;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006996,biological_process organelle organization;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0010507,biological_process negative regulation of autophagy;GO:0016887,molecular_function ATPase activity;GO:0046603,biological_process negative regulation of mitotic centrosome separation;GO:0051289,biological_process protein homotetramerization;GO:0051294,biological_process establishment of spindle orientation;GO:0051647,biological_process nucleus localization	NA	kinesin family member 25 [Source:HGNC Symbol%3BAcc:HGNC:6390]
ENSG00000161681	0.46	0.35	0.67	0.50	0.21	0.35	0.504558174417174	1.56669019934636	0.10002849516225	0.420543948794733	19:50661826-50719450:-	SHANK1	47;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007399,biological_process nervous system development;GO:0007616,biological_process long-term memory;GO:0008022,molecular_function protein C-terminus binding;GO:0008306,biological_process associative learning;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0017146,cellular_component NMDA selective glutamate receptor complex;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030160,molecular_function GKAP/Homer scaffold activity;GO:0030425,cellular_component dendrite;GO:0030534,biological_process adult behavior;GO:0031877,molecular_function somatostatin receptor binding;GO:0032232,biological_process negative regulation of actin filament bundle assembly;GO:0032403,molecular_function protein complex binding;GO:0035176,biological_process social behavior;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035418,biological_process protein localization to synapse;GO:0042048,biological_process olfactory behavior;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043197,cellular_component dendritic spine;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046959,biological_process habituation;GO:0050885,biological_process neuromuscular process controlling balance;GO:0050894,biological_process determination of affect;GO:0060013,biological_process righting reflex;GO:0060074,biological_process synapse maturation;GO:0060076,cellular_component excitatory synapse;GO:0060997,biological_process dendritic spine morphogenesis;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0071532,molecular_function ankyrin repeat binding;GO:0071625,biological_process vocalization behavior;GO:0097110,molecular_function scaffold protein binding;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential	SHANK; SH3 and multiple ankyrin repeat domains protein; K15009	SH3 and multiple ankyrin repeat domains 1 [Source:HGNC Symbol%3BAcc:HGNC:15474]
ENSG00000197563	14.83	16.85	13.85	13.88	14.04	13.93	0.127951964460132	5.59155784187891	0.100063810280747	0.420543948794733	18:61905254-62187118:-	PIGN	14;GO:0003824,molecular_function catalytic activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016780,molecular_function phosphotransferase activity, for other substituted phosphate groups;GO:0051377,molecular_function mannose-ethanolamine phosphotransferase activity	PIGN; GPI ethanolamine phosphate transferase 1 [EC:2.7.-.-]; K05285	phosphatidylinositol glycan anchor biosynthesis class N [Source:HGNC Symbol%3BAcc:HGNC:8967]
ENSG00000139132	2.36	2.28	2.69	2.50	3.17	3.09	-0.240526825085891	2.96704205433886	0.100120087573152	0.420543948794733	12:32399528-32646050:+	FGD4	24;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030035,biological_process microspike assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030175,cellular_component filopodium;GO:0031267,molecular_function small GTPase binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046847,biological_process filopodium assembly;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	FYVE%2C RhoGEF and PH domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:19125]
ENSG00000138185	0.74	0.94	1.09	0.42	0.75	0.74	0.543517484771067	0.492133407909431	0.100129636429893	0.420543948794733	10:95711778-95869695:+	ENTPD1	15;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0102490,molecular_function 8-oxo-dGTP phosphohydrolase activity	ENTPD1_3_8, CD39; apyrase [EC:3.6.1.5]; K01510	ectonucleoside triphosphate diphosphohydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:3363]
ENSG00000100029	75.03	73.35	73.02	83.11	73.74	84.43	-0.112292117630896	7.0905813390393	0.100140121872564	0.420543948794733	22:30576624-30607083:-	PES1	21;GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466,biological_process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000793,cellular_component condensed chromosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0007000,biological_process nucleolus organization;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0033365,biological_process protein localization to organelle;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0051726,biological_process regulation of cell cycle;GO:0070545,cellular_component PeBoW complex	NA	pescadillo ribosomal biogenesis factor 1 [Source:HGNC Symbol%3BAcc:HGNC:8848]
ENSG00000163633	12.83	10.14	12.15	16.25	14.49	12.44	-0.27001774814245	2.5159347671069	0.100147257926144	0.420543948794733	4:86876204-86936202:-	C4orf36	NA	NA	chromosome 4 open reading frame 36 [Source:HGNC Symbol%3BAcc:HGNC:28386]
ENSG00000144401	22.17	22.61	19.69	20.83	19.30	17.48	0.17214397964093	4.1063219973932	0.100294941882333	0.421021681970036	2:207580630-207625928:-	METTL21A	14;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0030544,molecular_function Hsp70 protein binding;GO:0031072,molecular_function heat shock protein binding;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex;GO:0051117,molecular_function ATPase binding	NA	methyltransferase like 21A [Source:HGNC Symbol%3BAcc:HGNC:30476]
ENSG00000186376	4.66	5.75	4.81	6.46	7.04	4.92	-0.269938584555921	3.1212595684338	0.10044642166964	0.421452374010494	X:135248919-135344087:-	ZNF75D	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 75D [Source:HGNC Symbol%3BAcc:HGNC:13145]
ENSG00000119397	2.35	2.61	2.53	2.20	2.28	2.27	0.155505254708047	4.06154924434803	0.100465445476279	0.421452374010494	9:121074862-121177610:+	CNTRL	16;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030496,cellular_component midbody;GO:0051301,biological_process cell division;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centriolin [Source:HGNC Symbol%3BAcc:HGNC:1858]
ENSG00000143337	20.12	21.26	22.42	18.52	22.06	17.39	0.150591223162263	5.32819612198186	0.10056695782761	0.421732638024748	1:179882041-179925000:+	TOR1AIP1	14;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0032781,biological_process positive regulation of ATPase activity;GO:0034504,biological_process protein localization to nucleus;GO:0051117,molecular_function ATPase binding;GO:0071763,biological_process nuclear membrane organization	NA	torsin 1A interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29456]
ENSG00000115306	112.91	104.77	115.35	125.48	113.78	122.24	-0.106391198021718	9.72337864664429	0.10062146615795	0.421732638024748	2:54456284-54671445:+	SPTBN1	43;GO:0000165,biological_process MAPK cascade;GO:0000281,biological_process mitotic cytokinesis;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007009,biological_process plasma membrane organization;GO:0007010,biological_process cytoskeleton organization;GO:0007182,biological_process common-partner SMAD protein phosphorylation;GO:0007184,biological_process SMAD protein import into nucleus;GO:0007411,biological_process axon guidance;GO:0008091,cellular_component spectrin;GO:0014069,cellular_component postsynaptic density;GO:0014731,cellular_component spectrin-associated cytoskeleton;GO:0016020,cellular_component membrane;GO:0030506,molecular_function ankyrin binding;GO:0030673,cellular_component axolemma;GO:0030863,cellular_component cortical cytoskeleton;GO:0031430,cellular_component M band;GO:0032403,molecular_function protein complex binding;GO:0032437,cellular_component cuticular plate;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0051020,molecular_function GTPase binding;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome;GO:0071709,biological_process membrane assembly;GO:0072661,biological_process protein targeting to plasma membrane;GO:1900042,biological_process positive regulation of interleukin-2 secretion;GO:1903076,biological_process regulation of protein localization to plasma membrane;GO:1903078,biological_process positive regulation of protein localization to plasma membrane	NA	spectrin beta%2C non-erythrocytic 1 [Source:HGNC Symbol%3BAcc:HGNC:11275]
ENSG00000157150	1.16	1.00	0.88	1.00	1.81	2.09	-0.677819313898537	0.0716403201778523	0.10063958195815	0.421732638024748	3:12153050-12159351:-	TIMP4	22;GO:0002020,molecular_function protease binding;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0007219,biological_process Notch signaling pathway;GO:0007417,biological_process central nervous system development;GO:0008150,biological_process biological_process;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0009725,biological_process response to hormone;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030017,cellular_component sarcomere;GO:0030414,molecular_function peptidase inhibitor activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0034097,biological_process response to cytokine;GO:0042493,biological_process response to drug;GO:0042698,biological_process ovulation cycle;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043434,biological_process response to peptide hormone;GO:0046872,molecular_function metal ion binding;GO:0051045,biological_process negative regulation of membrane protein ectodomain proteolysis	NA	TIMP metallopeptidase inhibitor 4 [Source:HGNC Symbol%3BAcc:HGNC:11823]
ENSG00000080493	15.35	16.94	15.89	16.14	20.14	17.14	-0.138722639258001	6.03543307000929	0.100668154875319	0.421732638024748	4:71186756-71572087:+	SLC4A4	22;GO:0005215,molecular_function transporter activity;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006820,biological_process anion transport;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0008510,molecular_function sodium:bicarbonate symporter activity;GO:0015293,molecular_function symporter activity;GO:0015698,biological_process inorganic anion transport;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0098656,biological_process anion transmembrane transport	SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4; K13575	solute carrier family 4 member 4 [Source:HGNC Symbol%3BAcc:HGNC:11030]
ENSG00000221886	5.83	6.70	6.81	7.90	7.11	7.18	-0.190489209961887	3.64291785300414	0.100720302729087	0.421808744188988	5:160393147-160400097:-	ZBED8	7;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter	NA	zinc finger BED-type containing 8 [Source:HGNC Symbol%3BAcc:HGNC:30804]
ENSG00000181035	5.03	5.11	6.25	5.18	4.13	4.20	0.295083567468787	2.29392667809234	0.100879943915793	0.422066316679444	19:19063998-19112888:+	SLC25A42	17;GO:0005347,molecular_function ATP transmembrane transporter activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0015217,molecular_function ADP transmembrane transporter activity;GO:0015228,molecular_function coenzyme A transmembrane transporter activity;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035349,biological_process coenzyme A transmembrane transport;GO:0043262,molecular_function adenosine-diphosphatase activity;GO:0055085,biological_process transmembrane transport;GO:0080121,biological_process AMP transport;GO:0080122,molecular_function AMP transmembrane transporter activity	NA	solute carrier family 25 member 42 [Source:HGNC Symbol%3BAcc:HGNC:28380]
ENSG00000197498	61.48	50.58	59.46	69.24	56.53	65.84	-0.14449042712819	5.86524977111573	0.100895178798269	0.422066316679444	6:110982014-111028263:+	RPF2	11;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008097,molecular_function 5S rRNA binding;GO:0019843,molecular_function rRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902570,biological_process protein localization to nucleolus	NA	ribosome production factor 2 homolog [Source:HGNC Symbol%3BAcc:HGNC:20870]
ENSG00000134152	26.55	22.53	24.39	22.05	23.63	21.38	0.150635985345352	4.63955219826191	0.100909398576995	0.422066316679444	15:34140673-34210096:-	KATNBL1	2;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus	NA	katanin regulatory subunit B1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:26199]
ENSG00000115594	38.81	34.13	36.88	38.99	37.75	44.02	-0.123130088927405	6.10049570780678	0.100917814219334	0.422066316679444	2:102064543-102179874:+	IL1R1	24;GO:0002020,molecular_function protease binding;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004908,molecular_function interleukin-1 receptor activity;GO:0004909,molecular_function interleukin-1, Type I, activating receptor activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019966,molecular_function interleukin-1 binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050727,biological_process regulation of inflammatory response;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0070555,biological_process response to interleukin-1;GO:2000391,biological_process positive regulation of neutrophil extravasation;GO:2000661,biological_process positive regulation of interleukin-1-mediated signaling pathway	IL1R1, CD121a; interleukin 1 receptor type I; K04386	interleukin 1 receptor type 1 [Source:HGNC Symbol%3BAcc:HGNC:5993]
ENSG00000129473	21.23	21.10	20.03	17.81	18.91	19.23	0.166128890113591	3.80549161459356	0.100978215208247	0.422176687564828	14:23298789-23311759:+	BCL2L2	22;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007283,biological_process spermatogenesis;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0051400,molecular_function BH domain binding;GO:0060011,biological_process Sertoli cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0097136,cellular_component Bcl-2 family protein complex;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097718,molecular_function disordered domain specific binding;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	BCLW; apoptosis regulator BCL-W; K02163	BCL2 like 2 [Source:HGNC Symbol%3BAcc:HGNC:995]
ENSG00000018699	15.21	13.68	13.72	16.26	14.51	16.20	-0.126701071958766	5.32053282883665	0.101075634512964	0.422441700743915	2:32628031-32821051:+	TTC27	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	tetratricopeptide repeat domain 27 [Source:HGNC Symbol%3BAcc:HGNC:25986]
ENSG00000196781	50.46	52.71	53.29	55.62	57.93	55.80	-0.102903662655244	7.02129348440949	0.101166830255563	0.422680533141133	9:81583682-81689305:-	TLE1	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0009887,biological_process organ morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0016055,biological_process Wnt signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:2000811,biological_process negative regulation of anoikis	NA	transducin like enhancer of split 1 [Source:HGNC Symbol%3BAcc:HGNC:11837]
ENSG00000143774	82.21	79.25	79.57	73.73	75.59	76.92	0.103576243137198	6.52886314334113	0.101300879235528	0.423003163358143	1:228139961-228148984:+	GUK1	19;GO:0000166,molecular_function nucleotide binding;GO:0004385,molecular_function guanylate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006163,biological_process purine nucleotide metabolic process;GO:0006185,biological_process dGDP biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019673,biological_process GDP-mannose metabolic process;GO:0034436,biological_process glycoprotein transport;GO:0046034,biological_process ATP metabolic process;GO:0046037,biological_process GMP metabolic process;GO:0046054,biological_process dGMP metabolic process;GO:0046060,biological_process dATP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0046711,biological_process GDP biosynthetic process;GO:0046939,biological_process nucleotide phosphorylation	E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]; K00942	guanylate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:4693]
ENSG00000107614	7.44	6.29	7.23	8.48	6.73	9.97	-0.248987046628776	3.31184309633637	0.101312205322143	0.423003163358143	10:17142253-17202054:-	TRDMT1	13;GO:0001975,biological_process response to amphetamine;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008175,molecular_function tRNA methyltransferase activity;GO:0016428,molecular_function tRNA (cytosine-5-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	tRNA aspartic acid methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:2977]
ENSG00000005249	7.04	8.61	5.34	7.16	10.52	8.24	-0.302809715194442	3.31040075415684	0.101349684074466	0.423017359924799	7:107044648-107161811:+	PRKAR2B	42;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003091,biological_process renal water homeostasis;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005952,cellular_component cAMP-dependent protein kinase complex;GO:0006631,biological_process fatty acid metabolic process;GO:0007596,biological_process blood coagulation;GO:0007612,biological_process learning;GO:0008603,molecular_function cAMP-dependent protein kinase regulator activity;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030425,cellular_component dendrite;GO:0030552,molecular_function cAMP binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034199,biological_process activation of protein kinase A activity;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0035556,biological_process intracellular signal transduction;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0045121,cellular_component membrane raft;GO:0045859,biological_process regulation of protein kinase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0097332,biological_process response to antipsychotic drug;GO:0097338,biological_process response to clozapine;GO:0097546,cellular_component ciliary base;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0098794,cellular_component postsynapse;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity	PRKAR; cAMP-dependent protein kinase regulator; K04739	protein kinase cAMP-dependent type II regulatory subunit beta [Source:HGNC Symbol%3BAcc:HGNC:9392]
ENSG00000116473	128.20	116.34	119.47	129.81	126.82	140.25	-0.111404372952333	6.13467724486504	0.101458622925828	0.423103985272622	1:111542217-111716691:+	RAP1A	51;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007399,biological_process nervous system development;GO:0008565,molecular_function protein transporter activity;GO:0009743,biological_process response to carbohydrate;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017016,molecular_function Ras GTPase binding;GO:0017034,molecular_function Rap guanyl-nucleotide exchange factor activity;GO:0030054,cellular_component cell junction;GO:0032045,cellular_component guanyl-nucleotide exchange factor complex;GO:0032403,molecular_function protein complex binding;GO:0032486,biological_process Rap protein signal transduction;GO:0032966,biological_process negative regulation of collagen biosynthetic process;GO:0035579,cellular_component specific granule membrane;GO:0035690,biological_process cellular response to drug;GO:0038180,biological_process nerve growth factor signaling pathway;GO:0043005,cellular_component neuron projection;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045335,cellular_component phagocytic vesicle;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046326,biological_process positive regulation of glucose import;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050796,biological_process regulation of insulin secretion;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071320,biological_process cellular response to cAMP;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0097327,biological_process response to antineoplastic agent;GO:0097421,biological_process liver regeneration;GO:1901888,biological_process regulation of cell junction assembly;GO:1905451,biological_process positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000301,biological_process negative regulation of synaptic vesicle exocytosis;GO:2001214,biological_process positive regulation of vasculogenesis	NA	RAP1A%2C member of RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9855]
ENSG00000170325	2.32	2.38	2.27	2.04	2.08	1.93	0.213857713651278	2.97706236471992	0.101488365057636	0.423103985272622	11:129899705-130002835:-	PRDM10	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	PR/SET domain 10 [Source:HGNC Symbol%3BAcc:HGNC:13995]
ENSG00000137760	5.71	5.56	6.93	8.34	5.79	7.41	-0.229096870101184	3.77128541122117	0.101497398283207	0.423103985272622	11:107502725-107565746:-	ALKBH8	25;GO:0000049,molecular_function tRNA binding;GO:0002098,biological_process tRNA wobble uridine modification;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0008198,molecular_function ferrous iron binding;GO:0008270,molecular_function zinc ion binding;GO:0016300,molecular_function tRNA (uracil) methyltransferase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016604,cellular_component nuclear body;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	alkB homolog 8%2C tRNA methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:25189]
ENSG00000196544	4.55	4.37	3.92	3.08	3.40	4.01	0.299168711733406	2.10697569933939	0.101506780644636	0.423103985272622	17:8188332-8190907:-	BORCS6	6;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0016020,cellular_component membrane;GO:0032418,biological_process lysosome localization;GO:0099078,cellular_component BORC complex	NA	BLOC-1 related complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:25939]
ENSG00000082153	133.35	140.46	130.08	148.81	140.07	148.40	-0.103749907591096	7.5746240553252	0.101685711711391	0.423707532552366	2:200810593-200827338:+	BZW1	6;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0045296,molecular_function cadherin binding	NA	basic leucine zipper and W2 domains 1 [Source:HGNC Symbol%3BAcc:HGNC:18380]
ENSG00000086570	0.12	0.15	0.16	0.09	0.12	0.10	0.492234868143879	0.817017030375349	0.101827256175453	0.424114552559406	5:151504092-151568944:-	FAT2	11;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010631,biological_process epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0070062,cellular_component extracellular exosome	NA	FAT atypical cadherin 2 [Source:HGNC Symbol%3BAcc:HGNC:3596]
ENSG00000142621	0.36	0.28	0.30	0.22	0.11	0.30	0.575550925793414	0.478279852972177	0.101865485348787	0.424114552559406	1:15247271-15400283:+	FHAD1	NA	NA	forkhead associated phosphopeptide binding domain 1 [Source:HGNC Symbol%3BAcc:HGNC:29408]
ENSG00000116809	10.40	10.52	10.33	11.66	10.52	12.53	-0.142280720147791	4.76289971782688	0.101885893477173	0.424114552559406	1:15941868-15976132:-	ZBTB17	29;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001223,molecular_function transcription coactivator binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001702,biological_process gastrulation with mouth forming second;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007398,biological_process ectoderm development;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0032993,cellular_component protein-DNA complex;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043234,cellular_component protein complex;GO:0045786,biological_process negative regulation of cell cycle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	ZBTB17, MIZ1; zinc finger and BTB domain-containing protein 17; K10500	zinc finger and BTB domain containing 17 [Source:HGNC Symbol%3BAcc:HGNC:12936]
ENSG00000263528	7.29	7.99	6.58	5.36	7.08	6.69	0.197335187994003	3.95064191481574	0.102023170969543	0.424543620933604	1:206470475-206496889:+	IKBKE	34;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004704,molecular_function NF-kappaB-inducing kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007252,biological_process I-kappaB phosphorylation;GO:0008384,molecular_function IkappaB kinase activity;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010008,cellular_component endosome membrane;GO:0010884,biological_process positive regulation of lipid storage;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032480,biological_process negative regulation of type I interferon production;GO:0034340,biological_process response to type I interferon;GO:0035456,biological_process response to interferon-beta;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0036435,molecular_function K48-linked polyubiquitin binding;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0051260,biological_process protein homooligomerization;GO:0098586,biological_process cellular response to virus	IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]; K07211	inhibitor of nuclear factor kappa B kinase subunit epsilon [Source:HGNC Symbol%3BAcc:HGNC:14552]
ENSG00000057757	53.44	49.37	55.93	51.93	44.45	49.21	0.139918255725202	5.01364988672154	0.102099163418825	0.424664112065967	1:23778404-23788232:+	PITHD1	2;GO:0005634,cellular_component nucleus;GO:0006974,biological_process cellular response to DNA damage stimulus	NA	PITH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25022]
ENSG00000104129	6.76	6.39	6.35	7.28	7.20	8.15	-0.202174069788298	3.20345552710507	0.102120548982269	0.424664112065967	15:40765154-40807478:-	DNAJC17	8;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:1901998,biological_process toxin transport	NA	DnaJ heat shock protein family (Hsp40) member C17 [Source:HGNC Symbol%3BAcc:HGNC:25556]
ENSG00000144535	7.46	7.53	7.52	8.47	7.97	8.34	-0.127620796621194	4.78106101973488	0.102397289489498	0.425624384260515	2:231961244-232344350:+	DIS3L2	28;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000178,cellular_component exosome (RNase complex);GO:0000278,biological_process mitotic cell cycle;GO:0000287,molecular_function magnesium ion binding;GO:0000291,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0006364,biological_process rRNA processing;GO:0007049,biological_process cell cycle;GO:0008266,molecular_function poly(U) RNA binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010587,biological_process miRNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019827,biological_process stem cell population maintenance;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0051306,biological_process mitotic sister chromatid separation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:1990074,biological_process polyuridylation-dependent mRNA catabolic process	NA	DIS3 like 3'-5' exoribonuclease 2 [Source:HGNC Symbol%3BAcc:HGNC:28648]
ENSG00000151233	8.61	8.76	9.53	9.93	10.74	10.02	-0.175536464735985	3.68360832055928	0.102436520482273	0.425624384260515	12:42081844-42144879:-	GXYLT1	6;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0035252,molecular_function UDP-xylosyltransferase activity	GXYLT; UDP-xylose:glucoside alpha-1,3-xylosyltransferase [EC:2.4.2.-]; K13676	glucoside xylosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:27482]
ENSG00000135697	5.25	5.08	5.20	5.52	6.87	5.82	-0.214658201912681	3.24526569482272	0.10245433498513	0.425624384260515	16:81238447-81291142:+	BCO1	12;GO:0001523,biological_process retinoid metabolic process;GO:0003834,molecular_function beta-carotene 15,15'-monooxygenase activity;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0035238,biological_process vitamin A biosynthetic process;GO:0042572,biological_process retinol metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:1901810,biological_process beta-carotene metabolic process	BCMO1, BCDO1; beta-carotene 15,15'-dioxygenase [EC:1.13.11.63]; K00515	beta-carotene oxygenase 1 [Source:HGNC Symbol%3BAcc:HGNC:13815]
ENSG00000126878	3.41	7.86	6.58	6.83	11.80	6.54	-0.49762799209563	2.04383135697175	0.102533752648605	0.425811800477464	9:131096475-131123152:+	AIF1L	15;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	NA	allograft inflammatory factor 1 like [Source:HGNC Symbol%3BAcc:HGNC:28904]
ENSG00000148180	37.21	35.64	35.55	34.28	34.64	32.65	0.106336226606982	6.52468791669126	0.102858336729552	0.426600528462485	9:121207793-121332843:+	GSN	69;GO:0001726,cellular_component ruffle;GO:0002102,cellular_component podosome;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006911,biological_process phagocytosis, engulfment;GO:0006915,biological_process apoptotic process;GO:0007568,biological_process aging;GO:0008154,biological_process actin polymerization or depolymerization;GO:0010628,biological_process positive regulation of gene expression;GO:0014003,biological_process oligodendrocyte development;GO:0014891,biological_process striated muscle atrophy;GO:0015629,cellular_component actin cytoskeleton;GO:0016192,biological_process vesicle-mediated transport;GO:0016528,cellular_component sarcoplasm;GO:0019904,molecular_function protein domain specific binding;GO:0030027,cellular_component lamellipodium;GO:0030030,biological_process cell projection organization;GO:0030041,biological_process actin filament polymerization;GO:0030155,biological_process regulation of cell adhesion;GO:0030478,cellular_component actin cap;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031648,biological_process protein destabilization;GO:0034774,cellular_component secretory granule lumen;GO:0042060,biological_process wound healing;GO:0042246,biological_process tissue regeneration;GO:0042989,biological_process sequestering of actin monomers;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0044267,biological_process cellular protein metabolic process;GO:0045010,biological_process actin nucleation;GO:0045159,molecular_function myosin II binding;GO:0045471,biological_process response to ethanol;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051014,biological_process actin filament severing;GO:0051015,molecular_function actin filament binding;GO:0051016,biological_process barbed-end actin filament capping;GO:0051127,biological_process positive regulation of actin nucleation;GO:0051593,biological_process response to folic acid;GO:0051693,biological_process actin filament capping;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071276,biological_process cellular response to cadmium ion;GO:0071801,biological_process regulation of podosome assembly;GO:0072562,cellular_component blood microparticle;GO:0090527,biological_process actin filament reorganization;GO:0097017,biological_process renal protein absorption;GO:0097284,biological_process hepatocyte apoptotic process;GO:1902174,biological_process positive regulation of keratinocyte apoptotic process;GO:1903689,biological_process regulation of wound healing, spreading of epidermal cells;GO:1903903,biological_process regulation of establishment of T cell polarity;GO:1903906,biological_process regulation of plasma membrane raft polarization;GO:1903909,biological_process regulation of receptor clustering;GO:1903923,biological_process positive regulation of protein processing in phagocytic vesicle;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1990000,biological_process amyloid fibril formation;GO:2001269,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GSN; gelsolin; K05768	gelsolin [Source:HGNC Symbol%3BAcc:HGNC:4620]
ENSG00000010322	24.85	23.92	25.58	23.11	22.82	23.91	0.103022575555784	6.83781669431882	0.102876734609327	0.426600528462485	3:52455117-52493071:+	NISCH	19;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006006,biological_process glucose metabolic process;GO:0006915,biological_process apoptotic process;GO:0008217,biological_process regulation of blood pressure;GO:0016020,cellular_component membrane;GO:0016601,biological_process Rac protein signal transduction;GO:0030036,biological_process actin cytoskeleton organization;GO:0030336,biological_process negative regulation of cell migration;GO:0032228,biological_process regulation of synaptic transmission, GABAergic;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042802,molecular_function identical protein binding;GO:0048243,biological_process norepinephrine secretion;GO:0055037,cellular_component recycling endosome	NA	nischarin [Source:HGNC Symbol%3BAcc:HGNC:18006]
ENSG00000148660	11.54	12.11	10.32	10.08	10.34	10.30	0.151777748625399	4.26120402667512	0.102910792048681	0.426600528462485	10:73812500-73874591:-	CAMK2G	43;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0004723,molecular_function calcium-dependent protein serine/threonine phosphatase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006470,biological_process protein dephosphorylation;GO:0006816,biological_process calcium ion transport;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0014069,cellular_component postsynaptic density;GO:0014733,biological_process regulation of skeletal muscle adaptation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030073,biological_process insulin secretion;GO:0030154,biological_process cell differentiation;GO:0030666,cellular_component endocytic vesicle membrane;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0035556,biological_process intracellular signal transduction;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046777,biological_process protein autophosphorylation;GO:0051259,biological_process protein oligomerization;GO:0051924,biological_process regulation of calcium ion transport;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:1900034,biological_process regulation of cellular response to heat;GO:1901897,biological_process regulation of relaxation of cardiac muscle	CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]; K04515	calcium/calmodulin dependent protein kinase II gamma [Source:HGNC Symbol%3BAcc:HGNC:1463]
ENSG00000159593	40.34	43.21	42.50	45.10	43.92	47.86	-0.108817685508786	6.37619046573596	0.10292807650735	0.426600528462485	16:66802874-66873256:-	NAE1	18;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0008641,molecular_function small protein activating enzyme activity;GO:0016020,cellular_component membrane;GO:0019781,molecular_function NEDD8 activating enzyme activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033314,biological_process mitotic DNA replication checkpoint;GO:0042981,biological_process regulation of apoptotic process;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0051402,biological_process neuron apoptotic process	NAE1, APPBP1; amyloid beta precursor protein binding protein 1; K04532	NEDD8 activating enzyme E1 subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:621]
ENSG00000162736	107.71	112.70	112.41	103.80	105.60	104.54	0.0957577377722073	7.96423267269754	0.102930405071161	0.426600528462485	1:160343271-160358952:+	NCSTN	34;GO:0002262,biological_process myeloid cell homeostasis;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034205,biological_process beta-amyloid formation;GO:0035577,cellular_component azurophil granule membrane;GO:0042098,biological_process T cell proliferation;GO:0042470,cellular_component melanosome;GO:0042982,biological_process amyloid precursor protein metabolic process;GO:0042987,biological_process amyloid precursor protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043312,biological_process neutrophil degranulation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050435,biological_process beta-amyloid metabolic process;GO:0050673,biological_process epithelial cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070765,cellular_component gamma-secretase complex	NCSTN; nicastrin; K06171	nicastrin [Source:HGNC Symbol%3BAcc:HGNC:17091]
ENSG00000205809	2.67	1.44	1.39	0.85	1.05	1.77	0.604020004997265	0.464602371816308	0.102952677582783	0.426600528462485	12:10426853-10442300:-	KLRC2	14;GO:0002228,biological_process natural killer cell mediated immunity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006968,biological_process cellular defense response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0023024,molecular_function MHC class I protein complex binding;GO:0030246,molecular_function carbohydrate binding;GO:0043235,cellular_component receptor complex;GO:0045087,biological_process innate immune response;GO:1990405,molecular_function protein antigen binding	KLRC, CD159; killer cell lectin-like receptor subfamily C; K06541	killer cell lectin like receptor C2 [Source:HGNC Symbol%3BAcc:HGNC:6375]
ENSG00000144028	63.07	66.22	61.12	67.35	71.81	66.88	-0.102430137388645	8.73388004473629	0.102964245812745	0.426600528462485	2:96274335-96305515:-	SNRNP200	24;GO:0000166,molecular_function nucleotide binding;GO:0000354,biological_process cis assembly of pre-catalytic spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0006397,biological_process mRNA processing;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042802,molecular_function identical protein binding;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071013,cellular_component catalytic step 2 spliceosome	SNRNP200, BRR2; pre-mRNA-splicing helicase BRR2 [EC:3.6.4.13]; K12854	small nuclear ribonucleoprotein U5 subunit 200 [Source:HGNC Symbol%3BAcc:HGNC:30859]
ENSG00000175054	5.65	5.41	5.25	5.09	4.65	5.35	0.122023576411743	5.40607203083811	0.10304937442189	0.426625294702296	3:142449234-142578826:-	ATR	39;GO:0000077,biological_process DNA damage checkpoint;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0008156,biological_process negative regulation of DNA replication;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032405,molecular_function MutLalpha complex binding;GO:0032407,molecular_function MutSalpha complex binding;GO:0034644,biological_process cellular response to UV;GO:0036297,biological_process interstrand cross-link repair;GO:0042493,biological_process response to drug;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0046777,biological_process protein autophosphorylation;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0071480,biological_process cellular response to gamma radiation;GO:0090399,biological_process replicative senescence;GO:0097694,biological_process establishment of RNA localization to telomere;GO:0097695,biological_process establishment of macromolecular complex localization to telomere;GO:1900034,biological_process regulation of cellular response to heat;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904884,biological_process positive regulation of telomerase catalytic core complex assembly	ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]; K06640	ATR serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:882]
ENSG00000167562	6.49	7.77	5.79	6.08	6.39	4.57	0.239647593265986	3.61273991182918	0.103085558682681	0.426625294702296	19:52555456-52587174:+	ZNF701	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 701 [Source:HGNC Symbol%3BAcc:HGNC:25597]
ENSG00000050393	12.68	13.39	13.77	15.40	13.90	15.30	-0.153382593165346	4.25285622306113	0.10310577116254	0.426625294702296	6:13786556-13814568:-	MCUR1	13;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0070509,biological_process calcium ion import	NA	mitochondrial calcium uniporter regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:21097]
ENSG00000044090	17.87	18.91	18.57	16.76	18.02	17.02	0.10676737430259	6.5796543035299	0.103177399621534	0.426625294702296	6:43037616-43053945:-	CUL7	26;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000281,biological_process mitotic cytokinesis;GO:0001570,biological_process vasculogenesis;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001890,biological_process placenta development;GO:0005515,molecular_function protein binding;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007030,biological_process Golgi organization;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0031467,cellular_component Cul7-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043687,biological_process post-translational protein modification;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:1990393,cellular_component 3M complex	CUL7; cullin 7; K10613	cullin 7 [Source:HGNC Symbol%3BAcc:HGNC:21024]
ENSG00000172403	0.34	0.12	0.21	0.46	0.37	0.23	-0.585960266353661	0.382733104160982	0.103208745328543	0.426625294702296	4:118850687-119061247:+	SYNPO2	19;GO:0000045,biological_process autophagosome assembly;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0015629,cellular_component actin cytoskeleton;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0031005,molecular_function filamin binding;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051371,molecular_function muscle alpha-actinin binding;GO:0051393,molecular_function alpha-actinin binding;GO:0071889,molecular_function 14-3-3 protein binding;GO:0099023,cellular_component tethering complex	NA	synaptopodin 2 [Source:HGNC Symbol%3BAcc:HGNC:17732]
ENSG00000138613	5.18	4.12	2.66	2.79	2.47	3.68	0.424856567203397	1.65141186072556	0.103243073748942	0.426625294702296	15:63276017-63309126:+	APH1B	17;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0030133,cellular_component transport vesicle;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0070765,cellular_component gamma-secretase complex	APH1A; gamma-secretase subunit APH-1A; K06172	aph-1 homolog B%2C gamma-secretase subunit [Source:HGNC Symbol%3BAcc:HGNC:24080]
ENSG00000105726	13.66	15.59	13.88	12.77	14.19	12.86	0.123743416218143	5.71982557275538	0.103246217537584	0.426625294702296	19:19645197-19663693:-	ATP13A1	22;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006812,biological_process cation transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0008150,biological_process biological_process;GO:0015410,molecular_function manganese-transporting ATPase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0034220,biological_process ion transmembrane transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071421,biological_process manganese ion transmembrane transport;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	NA	ATPase 13A1 [Source:HGNC Symbol%3BAcc:HGNC:24215]
ENSG00000213462	6.55	7.12	7.15	5.91	6.57	5.98	0.182897862272946	3.58332383296346	0.103256096131887	0.426625294702296	7:64990808-65006743:-	ERV3-1	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0019012,cellular_component virion;GO:0019031,cellular_component viral envelope;GO:0070062,cellular_component extracellular exosome	NA	endogenous retrovirus group 3 member 1%2C envelope [Source:HGNC Symbol%3BAcc:HGNC:3454]
ENSG00000147852	54.34	51.74	51.18	48.63	49.35	49.94	0.100480799444583	7.0601207576784	0.103279546490002	0.426625294702296	9:2621833-2660053:+	VLDLR	37;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007613,biological_process memory;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021517,biological_process ventral spinal cord development;GO:0030229,molecular_function very-low-density lipoprotein particle receptor activity;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0034185,molecular_function apolipoprotein binding;GO:0034189,molecular_function very-low-density lipoprotein particle binding;GO:0034361,cellular_component very-low-density lipoprotein particle;GO:0034436,biological_process glycoprotein transport;GO:0034437,molecular_function glycoprotein transporter activity;GO:0034447,biological_process very-low-density lipoprotein particle clearance;GO:0038025,molecular_function reelin receptor activity;GO:0038026,biological_process reelin-mediated signaling pathway;GO:0043235,cellular_component receptor complex;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048813,biological_process dendrite morphogenesis;GO:1900006,biological_process positive regulation of dendrite development	NA	very low density lipoprotein receptor [Source:HGNC Symbol%3BAcc:HGNC:12698]
ENSG00000177239	64.39	65.86	65.98	62.49	62.45	59.90	0.0979111353515331	7.54870371072457	0.103332598938194	0.426702445315969	9:137086926-137109187:+	MAN1B1	25;GO:0000139,cellular_component Golgi membrane;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006491,biological_process N-glycan processing;GO:0008152,biological_process metabolic process;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0036508,biological_process protein alpha-1,2-demannosylation;GO:0036509,biological_process trimming of terminal mannose on B branch;GO:0036510,biological_process trimming of terminal mannose on C branch;GO:0036511,biological_process trimming of first mannose on A branch;GO:0036512,biological_process trimming of second mannose on A branch;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:1903561,cellular_component extracellular vesicle;GO:1904380,biological_process endoplasmic reticulum mannose trimming;GO:1904382,biological_process mannose trimming involved in glycoprotein ERAD pathway	MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]; K01230	mannosidase alpha class 1B member 1 [Source:HGNC Symbol%3BAcc:HGNC:6823]
ENSG00000176485	69.49	60.45	69.02	54.12	57.41	68.62	0.15779712708974	4.98601989283537	0.103368945763891	0.426710583228194	11:63573194-63616883:-	PLA2G16	29;GO:0004623,molecular_function phospholipase A2 activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0007031,biological_process peroxisome organization;GO:0008654,biological_process phospholipid biosynthetic process;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016787,molecular_function hydrolase activity;GO:0036149,biological_process phosphatidylinositol acyl-chain remodeling;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0045786,biological_process negative regulation of cell cycle;GO:0046485,biological_process ether lipid metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0052739,molecular_function phosphatidylserine 1-acylhydrolase activity;GO:0052740,molecular_function 1-acyl-2-lysophosphatidylserine acylhydrolase activity;GO:1904177,biological_process regulation of adipose tissue development	PLA2G16; HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]; K16817	phospholipase A2 group XVI [Source:HGNC Symbol%3BAcc:HGNC:17825]
ENSG00000111727	3.54	4.06	3.69	3.62	3.32	2.69	0.235456573604911	3.06872330693586	0.103478065234296	0.42701902385416	12:104064456-104106524:+	HCFC2	9;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016032,biological_process viral process	HCFC; host cell factor; K14966	host cell factor C2 [Source:HGNC Symbol%3BAcc:HGNC:24972]
ENSG00000167992	0.40	0.29	0.52	0.28	0.35	0.16	0.644398020743714	0.204998577296436	0.103569678910897	0.427217227744994	11:61258285-61295424:-	VWCE	4;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009966,biological_process regulation of signal transduction	NA	von Willebrand factor C and EGF domains [Source:HGNC Symbol%3BAcc:HGNC:26487]
ENSG00000171202	42.93	41.09	42.32	50.45	44.98	44.72	-0.135427232500937	4.76327258107256	0.103594929147864	0.427217227744994	11:85647966-85656547:+	TMEM126A	6;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021554,biological_process optic nerve development	NA	transmembrane protein 126A [Source:HGNC Symbol%3BAcc:HGNC:25382]
ENSG00000213413	1.52	1.17	1.51	2.07	2.17	1.65	-0.453428524443611	0.856465767418539	0.103680355965518	0.427356209915019	7:100218240-100221490:+	PVRIG	5;GO:0004872,molecular_function receptor activity;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway	NA	poliovirus receptor related immunoglobulin domain containing [Source:HGNC Symbol%3BAcc:HGNC:32190]
ENSG00000103966	29.68	29.38	29.61	28.88	25.94	27.82	0.113553568763249	5.5393562122886	0.103697486849596	0.427356209915019	15:41895938-41972578:-	EHD4	23;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006907,biological_process pinocytosis;GO:0016020,cellular_component membrane;GO:0030100,biological_process regulation of endocytosis;GO:0031901,cellular_component early endosome membrane;GO:0032456,biological_process endocytic recycling;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051260,biological_process protein homooligomerization;GO:0055038,cellular_component recycling endosome membrane;GO:0070062,cellular_component extracellular exosome;GO:0071363,biological_process cellular response to growth factor stimulus	EHD4; EH domain-containing protein 4; K12477	EH domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:3245]
ENSG00000070269	7.67	6.62	6.53	6.24	6.66	5.63	0.186031468855377	3.87254245073334	0.103741415990874	0.427395352371298	14:56488353-56650606:+	TMEM260	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 260 [Source:HGNC Symbol%3BAcc:HGNC:20185]
ENSG00000068137	12.59	10.80	11.59	10.69	10.20	11.22	0.13993303593632	4.82335905147918	0.10391289709968	0.427959784903228	17:42667913-42676994:-	PLEKHH3	3;GO:0005615,cellular_component extracellular space;GO:0005856,cellular_component cytoskeleton;GO:0007165,biological_process signal transduction	NA	pleckstrin homology%2C MyTH4 and FERM domain containing H3 [Source:HGNC Symbol%3BAcc:HGNC:26105]
ENSG00000115761	19.08	20.91	20.61	22.24	23.31	20.89	-0.122743075601102	5.4940801099918	0.104113195598012	0.428642486553275	2:10570765-10689987:-	NOL10	3;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus	NA	nucleolar protein 10 [Source:HGNC Symbol%3BAcc:HGNC:25862]
ENSG00000054277	62.67	63.26	65.58	61.18	58.98	59.67	0.102771162072571	6.37720374967239	0.10430466675361	0.429288404646076	1:241590101-241677376:-	OPN3	16;GO:0001750,cellular_component photoreceptor outer segment;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007602,biological_process phototransduction;GO:0008020,molecular_function G-protein coupled photoreceptor activity;GO:0009583,biological_process detection of light stimulus;GO:0009584,biological_process detection of visible light;GO:0009881,molecular_function photoreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018298,biological_process protein-chromophore linkage;GO:0042752,biological_process regulation of circadian rhythm;GO:0050896,biological_process response to stimulus	NA	opsin 3 [Source:HGNC Symbol%3BAcc:HGNC:14007]
ENSG00000156515	42.14	41.14	45.58	40.97	36.87	42.08	0.116177412102223	6.91931593818607	0.104357546554277	0.429299050400145	10:69269983-69401882:+	HK1	31;GO:0000166,molecular_function nucleotide binding;GO:0001678,biological_process cellular glucose homeostasis;GO:0003824,molecular_function catalytic activity;GO:0004340,molecular_function glucokinase activity;GO:0004396,molecular_function hexokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005536,molecular_function glucose binding;GO:0005623,cellular_component cell;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0005975,biological_process carbohydrate metabolic process;GO:0006096,biological_process glycolytic process;GO:0008152,biological_process metabolic process;GO:0008865,molecular_function fructokinase activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019158,molecular_function mannokinase activity;GO:0019318,biological_process hexose metabolic process;GO:0045121,cellular_component membrane raft;GO:0046835,biological_process carbohydrate phosphorylation;GO:0051156,biological_process glucose 6-phosphate metabolic process;GO:0061621,biological_process canonical glycolysis;GO:0072655,biological_process establishment of protein localization to mitochondrion;GO:0072656,biological_process maintenance of protein location in mitochondrion;GO:0097228,cellular_component sperm principal piece	HK; hexokinase [EC:2.7.1.1]; K00844	hexokinase 1 [Source:HGNC Symbol%3BAcc:HGNC:4922]
ENSG00000095739	22.18	20.09	20.66	28.51	20.22	24.07	-0.195866430933392	4.15831769469923	0.10447133575715	0.429299050400145	10:28677341-28682939:+	BAMBI	16;GO:0005109,molecular_function frizzled binding;GO:0005114,molecular_function type II transforming growth factor beta receptor binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032092,biological_process positive regulation of protein binding;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	BAMBI; BMP and activin membrane-bound inhibitor; K10162	BMP and activin membrane bound inhibitor [Source:HGNC Symbol%3BAcc:HGNC:30251]
ENSG00000075643	25.93	22.13	27.52	29.99	24.77	29.67	-0.145157766670719	6.15727857527055	0.104508242883215	0.429299050400145	18:36187518-36272157:+	MOCOS	12;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0006777,biological_process Mo-molybdopterin cofactor biosynthetic process;GO:0008265,molecular_function Mo-molybdopterin cofactor sulfurase activity;GO:0016740,molecular_function transferase activity;GO:0030151,molecular_function molybdenum ion binding;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0032324,biological_process molybdopterin cofactor biosynthetic process;GO:0043545,biological_process molybdopterin cofactor metabolic process;GO:0102867,molecular_function molybdenum cofactor sulfurtransferase activity	ABA3; molybdenum cofactor sulfurtransferase [EC:2.8.1.9]; K15631	molybdenum cofactor sulfurase [Source:HGNC Symbol%3BAcc:HGNC:18234]
ENSG00000134109	21.15	22.39	22.11	20.57	18.22	21.75	0.126059910481561	5.41904466752798	0.104521039897088	0.429299050400145	3:5187645-5219957:+	EDEM1	22;GO:0000139,cellular_component Golgi membrane;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006491,biological_process N-glycan processing;GO:0006986,biological_process response to unfolded protein;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0036510,biological_process trimming of terminal mannose on C branch;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0051787,molecular_function misfolded protein binding;GO:0097466,biological_process glycoprotein ERAD pathway;GO:1904154,biological_process positive regulation of retrograde protein transport, ER to cytosol;GO:1904382,biological_process mannose trimming involved in glycoprotein ERAD pathway	EDEM1; ER degradation enhancer, mannosidase alpha-like 1; K10084	ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18967]
ENSG00000172638	56.57	51.42	59.31	51.74	51.01	53.43	0.113370617717149	6.46002738851785	0.104527299247212	0.429299050400145	11:65866440-65873592:-	EFEMP2	7;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005604,cellular_component basement membrane;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	NA	EGF containing fibulin like extracellular matrix protein 2 [Source:HGNC Symbol%3BAcc:HGNC:3219]
ENSG00000141385	47.53	50.72	50.79	53.64	53.67	53.94	-0.102629263098358	6.95271514299045	0.104547251179079	0.429299050400145	18:12328943-12377314:-	AFG3L2	31;GO:0000166,molecular_function nucleotide binding;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005745,cellular_component m-AAA complex;GO:0006508,biological_process proteolysis;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0007005,biological_process mitochondrion organization;GO:0007409,biological_process axonogenesis;GO:0007528,biological_process neuromuscular junction development;GO:0008053,biological_process mitochondrial fusion;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0021675,biological_process nerve development;GO:0031966,cellular_component mitochondrial membrane;GO:0034982,biological_process mitochondrial protein processing;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042407,biological_process cristae formation;GO:0042552,biological_process myelination;GO:0046872,molecular_function metal ion binding;GO:0048747,biological_process muscle fiber development;GO:0051082,molecular_function unfolded protein binding;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0060013,biological_process righting reflex	NA	AFG3 like matrix AAA peptidase subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:315]
ENSG00000169826	13.46	8.70	13.17	10.68	9.33	10.55	0.231031317807611	4.18056572915231	0.104549345795508	0.429299050400145	10:43138485-43185308:+	CSGALNACT2	18;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030166,biological_process proteoglycan biosynthetic process;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0047237,molecular_function glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0047238,molecular_function glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0050650,biological_process chondroitin sulfate proteoglycan biosynthetic process;GO:0050651,biological_process dermatan sulfate proteoglycan biosynthetic process;GO:0050652,biological_process dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0050653,biological_process chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	CSGALNACT1_2; chondroitin sulfate N-acetylgalactosaminyltransferase 1/2 [EC:2.4.1.174 2.4.1.175]; K00746	chondroitin sulfate N-acetylgalactosaminyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:24292]
ENSG00000249471	1.54	1.34	1.49	1.05	1.36	0.95	0.404252252788011	1.2900192742063	0.10465358343551	0.429584964016197	19:58451603-58457833:+	ZNF324B	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 324B [Source:HGNC Symbol%3BAcc:HGNC:33107]
ENSG00000157538	43.36	45.15	46.92	41.60	40.26	43.88	0.117608095984349	5.2832879979443	0.104695509427502	0.42961499455325	21:37223419-37267919:-	DSCR3	6;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005768,cellular_component endosome;GO:0006886,biological_process intracellular protein transport;GO:0008150,biological_process biological_process;GO:0008565,molecular_function protein transporter activity	NA	DSCR3 arrestin fold containing [Source:HGNC Symbol%3BAcc:HGNC:3044]
ENSG00000133103	11.35	11.18	10.59	9.80	10.62	9.88	0.139635174224455	4.47114594607009	0.10485040112315	0.43010840354979	13:39655626-39791665:+	COG6	11;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032588,cellular_component trans-Golgi network membrane;GO:0070085,biological_process glycosylation	NA	component of oligomeric golgi complex 6 [Source:HGNC Symbol%3BAcc:HGNC:18621]
ENSG00000171067	12.48	14.97	14.59	13.56	11.26	12.63	0.172071519162234	4.16602490518702	0.104935208076945	0.430314085847081	11:68261334-68272001:-	C11orf24	4;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 11 open reading frame 24 [Source:HGNC Symbol%3BAcc:HGNC:1174]
ENSG00000231925	116.95	113.53	121.27	109.29	107.09	114.52	0.10035829365443	7.4877411254709	0.105001305661022	0.430351765187534	6:33299693-33314387:-	TAPBP	30;GO:0000139,cellular_component Golgi membrane;GO:0002397,biological_process MHC class I protein complex assembly;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006461,biological_process protein complex assembly;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006955,biological_process immune response;GO:0010468,biological_process regulation of gene expression;GO:0015433,molecular_function peptide antigen-transporting ATPase activity;GO:0015833,biological_process peptide transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019885,biological_process antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042288,molecular_function MHC class I protein binding;GO:0042605,molecular_function peptide antigen binding;GO:0042824,cellular_component MHC class I peptide loading complex;GO:0042825,cellular_component TAP complex;GO:0042886,biological_process amide transport;GO:0046978,molecular_function TAP1 binding;GO:0046979,molecular_function TAP2 binding;GO:0050823,biological_process peptide antigen stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0061635,biological_process regulation of protein complex stability;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:1990668,biological_process vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	TAPBP; TAP binding protein (tapasin); K08058	TAP binding protein [Source:HGNC Symbol%3BAcc:HGNC:11566]
ENSG00000136371	1.88	2.77	2.13	1.27	1.92	1.61	0.482044743290903	0.786084448952	0.10504369270169	0.430351765187534	15:79833584-79897379:-	MTHFS	16;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005542,molecular_function folic acid binding;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006536,biological_process glutamate metabolic process;GO:0009396,biological_process folic acid-containing compound biosynthetic process;GO:0015942,biological_process formate metabolic process;GO:0016874,molecular_function ligase activity;GO:0030272,molecular_function 5-formyltetrahydrofolate cyclo-ligase activity;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046655,biological_process folic acid metabolic process;GO:0046657,biological_process folic acid catabolic process;GO:0046872,molecular_function metal ion binding	MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]; K01934	methenyltetrahydrofolate synthetase [Source:HGNC Symbol%3BAcc:HGNC:7437]
ENSG00000176182	3.95	3.91	4.00	3.32	3.48	3.05	0.28167051249317	2.16153361448036	0.105048404778718	0.430351765187534	19:45890019-45902604:-	MYPOP	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity	NA	Myb related transcription factor%2C partner of profilin [Source:HGNC Symbol%3BAcc:HGNC:20178]
ENSG00000155792	3.63	3.27	3.06	4.33	4.45	3.50	-0.283830225335665	2.23601463421484	0.105321281060305	0.431327305114338	8:119873716-120050913:+	DEPTOR	8;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0032007,biological_process negative regulation of TOR signaling;GO:0035556,biological_process intracellular signal transduction;GO:0045792,biological_process negative regulation of cell size;GO:2001236,biological_process regulation of extrinsic apoptotic signaling pathway	NA	DEP domain containing MTOR interacting protein [Source:HGNC Symbol%3BAcc:HGNC:22953]
ENSG00000177666	108.04	102.96	113.08	100.67	98.51	105.06	0.103714030368453	7.30952830118092	0.105480937668324	0.4318386805003	11:818901-825573:+	PNPLA2	26;GO:0004465,molecular_function lipoprotein lipase activity;GO:0004806,molecular_function triglyceride lipase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0008152,biological_process metabolic process;GO:0010891,biological_process negative regulation of sequestering of triglyceride;GO:0010898,biological_process positive regulation of triglyceride catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016411,molecular_function acylglycerol O-acyltransferase activity;GO:0016787,molecular_function hydrolase activity;GO:0019433,biological_process triglyceride catabolic process;GO:0019915,biological_process lipid storage;GO:0034389,biological_process lipid particle organization;GO:0036155,biological_process acylglycerol acyl-chain remodeling;GO:0043687,biological_process post-translational protein modification;GO:0044242,biological_process cellular lipid catabolic process;GO:0044267,biological_process cellular protein metabolic process;GO:0055088,biological_process lipid homeostasis	PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]; K16816	patatin like phospholipase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30802]
ENSG00000197142	4.30	3.28	4.32	5.47	4.14	4.60	-0.232442848669952	3.30302381068283	0.105546635074718	0.431936168445621	10:112374017-112428380:+	ACSL5	20;GO:0000166,molecular_function nucleotide binding;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0102391,molecular_function decanoate--CoA ligase activity	ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]; K01897	acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol%3BAcc:HGNC:16526]
ENSG00000138685	22.72	20.02	19.68	25.22	21.59	23.60	-0.158644673169456	4.27319630026519	0.105591134299551	0.431936168445621	4:122826707-122898236:+	FGF2	68;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005104,molecular_function fibroblast growth factor receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006935,biological_process chemotaxis;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009887,biological_process organ morphogenesis;GO:0010764,biological_process negative regulation of fibroblast migration;GO:0010863,biological_process positive regulation of phospholipase C activity;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014843,biological_process growth factor dependent regulation of skeletal muscle satellite cell proliferation;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0030214,biological_process hyaluronan catabolic process;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0032958,biological_process inositol phosphate biosynthetic process;GO:0035019,biological_process somatic stem cell population maintenance;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042056,molecular_function chemoattractant activity;GO:0042060,biological_process wound healing;GO:0042660,biological_process positive regulation of cell fate specification;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0043537,biological_process negative regulation of blood vessel endothelial cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045765,biological_process regulation of angiogenesis;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048598,biological_process embryonic morphogenesis;GO:0050918,biological_process positive chemotaxis;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051781,biological_process positive regulation of cell division;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060548,biological_process negative regulation of cell death;GO:0060591,biological_process chondroblast differentiation;GO:0061045,biological_process negative regulation of wound healing;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0072089,biological_process stem cell proliferation;GO:0090722,molecular_function receptor-receptor interaction;GO:1903672,biological_process positive regulation of sprouting angiogenesis;GO:2000544,biological_process regulation of endothelial cell chemotaxis to fibroblast growth factor;GO:2000546,biological_process positive regulation of endothelial cell chemotaxis to fibroblast growth factor	FGF; fibroblast growth factor; K04358	fibroblast growth factor 2 [Source:HGNC Symbol%3BAcc:HGNC:3676]
ENSG00000205795	3.58	0.60	2.02	2.53	4.32	2.97	-0.580452597882795	0.540827583157085	0.105626636126195	0.431936168445621	2:10056779-10080944:-	CYS1	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0016020,cellular_component membrane;GO:0042995,cellular_component cell projection;GO:0060170,cellular_component ciliary membrane;GO:0070062,cellular_component extracellular exosome	NA	cystin 1 [Source:HGNC Symbol%3BAcc:HGNC:18525]
ENSG00000129460	30.94	29.95	33.08	36.43	32.53	34.80	-0.128568762419683	5.00829196427268	0.10564393840336	0.431936168445621	14:23469687-23509862:+	NGDN	15;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000775,cellular_component chromosome, centromeric region;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006417,biological_process regulation of translation;GO:0030175,cellular_component filopodium;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0032040,cellular_component small-subunit processome;GO:0042995,cellular_component cell projection	NA	neuroguidin [Source:HGNC Symbol%3BAcc:HGNC:20271]
ENSG00000137817	28.61	23.18	30.72	26.30	23.53	25.24	0.152762361737141	5.68659987881975	0.105697214710176	0.431996458736064	15:72241180-72272999:-	PARP6	3;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	poly(ADP-ribose) polymerase family member 6 [Source:HGNC Symbol%3BAcc:HGNC:26921]
ENSG00000164889	82.74	74.73	85.36	74.21	75.20	78.07	0.106703177700373	8.20376026615073	0.105728288217205	0.431996458736064	7:151057209-151076527:+	SLC4A2	25;GO:0005215,molecular_function transporter activity;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0007283,biological_process spermatogenesis;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0008510,molecular_function sodium:bicarbonate symporter activity;GO:0015297,molecular_function antiporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015698,biological_process inorganic anion transport;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019899,molecular_function enzyme binding;GO:0035725,biological_process sodium ion transmembrane transport;GO:0048565,biological_process digestive tract development;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2; K13855	solute carrier family 4 member 2 [Source:HGNC Symbol%3BAcc:HGNC:11028]
ENSG00000164953	16.10	14.49	17.00	17.94	16.66	17.60	-0.117377726802803	5.77542585313123	0.105851465402347	0.432357433379184	8:93754843-93819234:+	TMEM67	22;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0010826,biological_process negative regulation of centrosome duplication;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031005,molecular_function filamin binding;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0042995,cellular_component cell projection;GO:0051082,molecular_function unfolded protein binding;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	transmembrane protein 67 [Source:HGNC Symbol%3BAcc:HGNC:28396]
ENSG00000215126	10.25	8.49	9.34	7.96	7.94	8.92	0.196612519897063	3.49836769814294	0.105895564240946	0.432395275961469	9:41131305-41199261:-	CBWD6	2;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding	NA	COBW domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:31978]
ENSG00000204852	23.98	21.11	23.68	19.17	21.06	23.16	0.131861498549911	5.70593572846745	0.105970956722911	0.432560830582538	12:110614026-110649430:+	TCTN1	21;GO:0001701,biological_process in utero embryonic development;GO:0001841,biological_process neural tube formation;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007275,biological_process multicellular organism development;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0021523,biological_process somatic motor neuron differentiation;GO:0021537,biological_process telencephalon development;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021956,biological_process central nervous system interneuron axonogenesis;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1904491,biological_process protein localization to ciliary transition zone	NA	tectonic family member 1 [Source:HGNC Symbol%3BAcc:HGNC:26113]
ENSG00000163507	14.63	16.57	14.55	15.37	18.73	16.68	-0.142198082159595	5.47789621147241	0.106116905715093	0.433014184957742	3:108549868-108589644:-	KIAA1524	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045296,molecular_function cadherin binding;GO:2000179,biological_process positive regulation of neural precursor cell proliferation	NA	KIAA1524 [Source:HGNC Symbol%3BAcc:HGNC:29302]
ENSG00000130826	51.59	47.21	47.98	54.98	51.41	53.02	-0.105742178799281	6.33504218976278	0.106185162336264	0.433150318790681	X:154762741-154777689:+	DKC1	38;GO:0000495,biological_process box H/ACA snoRNA 3'-end processing;GO:0001522,biological_process pseudouridine synthesis;GO:0001650,cellular_component fibrillar center;GO:0003720,molecular_function telomerase activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0007004,biological_process telomere maintenance via telomerase;GO:0008283,biological_process cell proliferation;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016853,molecular_function isomerase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031118,biological_process rRNA pseudouridine synthesis;GO:0031120,biological_process snRNA pseudouridine synthesis;GO:0031429,cellular_component box H/ACA snoRNP complex;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0033979,biological_process box H/ACA snoRNA metabolic process;GO:0034513,molecular_function box H/ACA snoRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0051973,biological_process positive regulation of telomerase activity;GO:0070034,molecular_function telomerase RNA binding;GO:0072589,cellular_component box H/ACA scaRNP complex;GO:0090661,cellular_component box H/ACA telomerase RNP complex;GO:0090669,biological_process telomerase RNA stabilization;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904872,biological_process regulation of telomerase RNA localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body;GO:1990481,biological_process mRNA pseudouridine synthesis	DKC1, NOLA4, CBF5; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]; K11131	dyskerin pseudouridine synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:2890]
ENSG00000138785	21.66	20.52	21.59	24.69	22.30	23.19	-0.124022131255366	5.00119803416289	0.106280817825678	0.433266486476483	4:105682626-105895986:-	INTS12	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016180,biological_process snRNA processing;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	integrator complex subunit 12 [Source:HGNC Symbol%3BAcc:HGNC:25067]
ENSG00000135506	161.82	151.56	160.83	145.32	148.56	153.42	0.0965268637285261	8.32410421515746	0.106283448910085	0.433266486476483	12:57693954-57721557:+	OS9	17;GO:0000836,cellular_component Hrd1p ubiquitin ligase complex;GO:0002020,molecular_function protease binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006605,biological_process protein targeting;GO:0006621,biological_process protein retention in ER lumen;GO:0016567,biological_process protein ubiquitination;GO:0030246,molecular_function carbohydrate binding;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0055085,biological_process transmembrane transport;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol;GO:1904380,biological_process endoplasmic reticulum mannose trimming	OS9; protein OS-9; K10088	OS9%2C endoplasmic reticulum lectin [Source:HGNC Symbol%3BAcc:HGNC:16994]
ENSG00000117519	395.85	422.25	401.11	369.05	405.65	368.40	0.104491894009437	8.60360184586836	0.106428479625405	0.433557141380299	1:94896948-94927278:-	CNN3	16;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005829,cellular_component cytosol;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0008017,molecular_function microtubule binding;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0030425,cellular_component dendrite;GO:0030855,biological_process epithelial cell differentiation;GO:0031032,biological_process actomyosin structure organization;GO:0032780,biological_process negative regulation of ATPase activity;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	NA	calponin 3 [Source:HGNC Symbol%3BAcc:HGNC:2157]
ENSG00000185909	4.52	4.05	4.50	4.72	5.71	5.43	-0.259456471628023	2.406723746197	0.106429263316252	0.433557141380299	3:49171610-49176486:+	KLHDC8B	5;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch domain containing 8B [Source:HGNC Symbol%3BAcc:HGNC:28557]
ENSG00000170946	17.81	19.01	19.06	21.58	19.64	22.55	-0.182897637127347	3.56060399565246	0.106459531694768	0.433557141380299	11:31369839-31431849:+	DNAJC24	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	DnaJ heat shock protein family (Hsp40) member C24 [Source:HGNC Symbol%3BAcc:HGNC:26979]
ENSG00000040933	5.63	4.95	5.30	5.97	5.95	5.90	-0.147908136745721	4.14393012958118	0.10661583595243	0.434051286217616	2:98444853-98594390:+	INPP4A	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007165,biological_process signal transduction;GO:0016311,biological_process dephosphorylation;GO:0016316,molecular_function phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0017161,molecular_function inositol-1,3,4-trisphosphate 4-phosphatase activity;GO:0034597,molecular_function phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0043647,biological_process inositol phosphate metabolic process;GO:0052828,molecular_function inositol-3,4-bisphosphate 4-phosphatase activity	INPP4; inositol polyphosphate-4-phosphatase [EC:3.1.3.66]; K01109	inositol polyphosphate-4-phosphatase type I A [Source:HGNC Symbol%3BAcc:HGNC:6074]
ENSG00000137094	4.73	4.81	4.52	4.24	4.19	3.54	0.24455472612101	2.6817177345072	0.106777035804905	0.434456132693461	9:34989640-34998900:+	DNAJB5	8;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006986,biological_process response to unfolded protein;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding	NA	DnaJ heat shock protein family (Hsp40) member B5 [Source:HGNC Symbol%3BAcc:HGNC:14887]
ENSG00000138018	5.40	5.38	6.61	7.04	6.37	7.14	-0.225288656358882	2.94829232496166	0.106785278405522	0.434456132693461	2:26308546-26395891:+	SELENOI	11;GO:0004307,molecular_function ethanolaminephosphotransferase activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016780,molecular_function phosphotransferase activity, for other substituted phosphate groups;GO:0046872,molecular_function metal ion binding;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	EPT1; ethanolaminephosphotransferase [EC:2.7.8.1]; K00993	selenoprotein I [Source:HGNC Symbol%3BAcc:HGNC:29361]
ENSG00000143256	98.91	80.26	94.31	112.63	88.81	106.39	-0.15501949863784	5.49385250901787	0.106892640564417	0.434750441456785	1:161100555-161118111:-	PFDN2	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0016272,cellular_component prefoldin complex;GO:0044183,molecular_function protein binding involved in protein folding;GO:0051082,molecular_function unfolded protein binding;GO:0051495,biological_process positive regulation of cytoskeleton organization;GO:0070062,cellular_component extracellular exosome	NA	prefoldin subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:8867]
ENSG00000119335	309.68	308.61	324.45	352.68	327.99	336.62	-0.0978897389674019	8.39459265000897	0.107109671880459	0.435366434291808	9:128683423-128696400:+	SET	24;GO:0003677,molecular_function DNA binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006334,biological_process nucleosome assembly;GO:0006337,biological_process nucleosome disassembly;GO:0006913,biological_process nucleocytoplasmic transport;GO:0016032,biological_process viral process;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0035067,biological_process negative regulation of histone acetylation;GO:0042393,molecular_function histone binding;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0043488,biological_process regulation of mRNA stability;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050790,biological_process regulation of catalytic activity	NA	SET nuclear proto-oncogene [Source:HGNC Symbol%3BAcc:HGNC:10760]
ENSG00000161277	3.61	5.70	4.03	2.28	3.97	3.85	0.389646170692131	1.72771094705261	0.107142901366397	0.435366434291808	19:36034984-36054762:-	THAP8	4;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:23191]
ENSG00000141013	10.98	10.74	12.20	12.65	13.44	12.06	-0.153382176972761	4.23987510642377	0.107149315778738	0.435366434291808	16:90019628-90044975:+	GAS8	25;GO:0003351,biological_process epithelial cilium movement;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007368,biological_process determination of left/right symmetry;GO:0007420,biological_process brain development;GO:0008017,molecular_function microtubule binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0017137,molecular_function Rab GTPase binding;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0034613,biological_process cellular protein localization;GO:0035082,biological_process axoneme assembly;GO:0036064,cellular_component ciliary basal body;GO:0036126,cellular_component sperm flagellum;GO:0042995,cellular_component cell projection;GO:0048870,biological_process cell motility;GO:0060294,biological_process cilium movement involved in cell motility;GO:0097729,cellular_component 9+2 motile cilium;GO:1904526,biological_process regulation of microtubule binding	NA	growth arrest specific 8 [Source:HGNC Symbol%3BAcc:HGNC:4166]
ENSG00000198920	12.79	12.42	13.57	14.26	14.40	13.73	-0.113894228194972	5.32885736352567	0.107232162383303	0.435540645309516	17:6578147-6640927:-	KIAA0753	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007099,biological_process centriole replication;GO:0034451,cellular_component centriolar satellite;GO:0071539,biological_process protein localization to centrosome	NA	KIAA0753 [Source:HGNC Symbol%3BAcc:HGNC:29110]
ENSG00000175699	1.07	1.25	0.74	0.38	0.99	0.50	0.70358663683936	-0.0730799399546269	0.107262366286247	0.435540645309516	14:93987224-94008863:+	CCDC197	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	coiled-coil domain containing 197 [Source:HGNC Symbol%3BAcc:HGNC:19860]
ENSG00000213639	197.02	196.50	191.53	205.87	208.08	215.81	-0.0946219645644343	7.89479763814208	0.107302076866639	0.435559411427598	2:28751639-28802940:+	PPP1CB	33;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005979,biological_process regulation of glycogen biosynthetic process;GO:0005981,biological_process regulation of glycogen catabolic process;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017018,molecular_function myosin phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0030155,biological_process regulation of cell adhesion;GO:0032922,biological_process circadian regulation of gene expression;GO:0042587,cellular_component glycogen granule;GO:0042752,biological_process regulation of circadian rhythm;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0050115,molecular_function myosin-light-chain-phosphatase activity;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0072357,cellular_component PTW/PP1 phosphatase complex	PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]; K06269	protein phosphatase 1 catalytic subunit beta [Source:HGNC Symbol%3BAcc:HGNC:9282]
ENSG00000105173	2.30	2.33	3.05	2.68	3.70	3.49	-0.342937906647069	1.91530548443113	0.107354376282502	0.435629249033898	19:29811897-29824308:+	CCNE1	27;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0000723,biological_process telomere maintenance;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006270,biological_process DNA replication initiation;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007129,biological_process synapsis;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0045859,biological_process regulation of protein kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050681,molecular_function androgen receptor binding;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle;GO:0070192,biological_process chromosome organization involved in meiotic cell cycle;GO:0097134,cellular_component cyclin E1-CDK2 complex;GO:1903827,biological_process regulation of cellular protein localization	CCNE; G1/S-specific cyclin-E1; K06626	cyclin E1 [Source:HGNC Symbol%3BAcc:HGNC:1589]
ENSG00000114473	7.98	10.18	8.27	7.81	7.63	7.64	0.193882832903898	3.51030017982455	0.107500430760391	0.436079361774095	3:197889074-197960142:-	IQCG	14;GO:0002177,cellular_component manchette;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0007288,biological_process sperm axoneme assembly;GO:0030154,biological_process cell differentiation;GO:0030544,molecular_function Hsp70 protein binding;GO:0031514,cellular_component motile cilium;GO:0036126,cellular_component sperm flagellum;GO:0042995,cellular_component cell projection;GO:0070062,cellular_component extracellular exosome	NA	IQ motif containing G [Source:HGNC Symbol%3BAcc:HGNC:25251]
ENSG00000122735	0.64	0.68	0.52	0.50	0.29	0.47	0.547219863502459	0.297617512330516	0.107609720953828	0.436366540192376	9:34457413-34520989:+	DNAI1	21;GO:0003341,biological_process cilium movement;GO:0003351,biological_process epithelial cilium movement;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0030030,biological_process cell projection organization;GO:0030286,cellular_component dynein complex;GO:0030317,biological_process sperm motility;GO:0036157,cellular_component outer dynein arm;GO:0036158,biological_process outer dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045504,molecular_function dynein heavy chain binding	DNAI1; dynein intermediate chain 1, axonemal; K10409	dynein axonemal intermediate chain 1 [Source:HGNC Symbol%3BAcc:HGNC:2954]
ENSG00000118412	4.58	4.86	5.42	5.72	5.22	5.55	-0.137098046442688	4.95972739851595	0.107641532753489	0.436366540192376	6:89829893-89874436:+	CASP8AP2	5;GO:0002020,molecular_function protease binding;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0042802,molecular_function identical protein binding	NA	caspase 8 associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1510]
ENSG00000115425	21.29	23.76	20.89	24.38	25.11	23.90	-0.14937953830614	4.40932086658013	0.107873253079043	0.43714872518589	2:215996328-216082955:-	PECR	12;GO:0001561,biological_process fatty acid alpha-oxidation;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0019166,molecular_function trans-2-enoyl-CoA reductase (NADPH) activity;GO:0033306,biological_process phytol metabolic process;GO:0055114,biological_process oxidation-reduction process	PECR; peroxisomal trans-2-enoyl-CoA reductase [EC:1.3.1.38]; K07753	peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol%3BAcc:HGNC:18281]
ENSG00000186625	20.57	18.68	18.34	21.91	22.45	19.62	-0.13650257339354	4.90900632076972	0.107904913717036	0.43714872518589	6:149594872-149648972:-	KATNA1	18;GO:0000166,molecular_function nucleotide binding;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008568,molecular_function microtubule-severing ATPase activity;GO:0016787,molecular_function hydrolase activity;GO:0030496,cellular_component midbody;GO:0046982,molecular_function protein heterodimerization activity;GO:0051013,biological_process microtubule severing;GO:0051301,biological_process cell division	NA	katanin catalytic subunit A1 [Source:HGNC Symbol%3BAcc:HGNC:6216]
ENSG00000130640	11.99	13.20	13.42	13.99	14.59	13.73	-0.122049740392027	5.28276784093858	0.108035771548022	0.437319136634717	10:133278629-133312337:-	TUBGCP2	24;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000922,cellular_component spindle pole;GO:0000923,cellular_component equatorial microtubule organizing center;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006461,biological_process protein complex assembly;GO:0007020,biological_process microtubule nucleation;GO:0008275,cellular_component gamma-tubulin small complex;GO:0016020,cellular_component membrane;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0043015,molecular_function gamma-tubulin binding;GO:0051011,molecular_function microtubule minus-end binding;GO:0051298,biological_process centrosome duplication;GO:0051321,biological_process meiotic cell cycle;GO:0051415,biological_process interphase microtubule nucleation by interphase microtubule organizing center;GO:0090307,biological_process mitotic spindle assembly	NA	tubulin gamma complex associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18599]
ENSG00000116754	117.71	113.52	126.27	110.14	109.63	115.81	0.10371161377677	7.60016338572963	0.108046769416581	0.437319136634717	1:70205681-70253052:+	SRSF11	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing	NA	serine and arginine rich splicing factor 11 [Source:HGNC Symbol%3BAcc:HGNC:10782]
ENSG00000138674	69.40	75.44	70.14	66.92	70.29	64.30	0.104502101932201	8.10965062315949	0.108052669947529	0.437319136634717	4:82818660-82901166:-	SEC31A	26;GO:0000139,cellular_component Golgi membrane;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030120,cellular_component vesicle coat;GO:0030127,cellular_component COPII vesicle coat;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048208,biological_process COPII vesicle coating;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051592,biological_process response to calcium ion;GO:0070971,cellular_component endoplasmic reticulum exit site;GO:0090110,biological_process cargo loading into COPII-coated vesicle	SEC31; protein transport protein SEC31; K14005	SEC31 homolog A%2C COPII coat complex component [Source:HGNC Symbol%3BAcc:HGNC:17052]
ENSG00000137693	44.54	43.71	45.59	45.59	47.53	52.74	-0.112147031489149	6.15547461885666	0.108140617849649	0.437532428085949	11:102110460-102233423:+	YAP1	26;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008283,biological_process cell proliferation;GO:0033613,molecular_function activating transcription factor binding;GO:0035329,biological_process hippo signaling;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0050767,biological_process regulation of neurogenesis;GO:0060242,biological_process contact inhibition;GO:0071148,cellular_component TEAD-1-YAP complex;GO:0071149,cellular_component TEAD-2-YAP complex;GO:0071480,biological_process cellular response to gamma radiation;GO:0072091,biological_process regulation of stem cell proliferation;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	YAP1, Yki; transcriptional coactivator YAP1; K16687	Yes associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16262]
ENSG00000170832	20.28	19.72	21.01	19.54	18.88	18.88	0.102915099444198	6.685978588645	0.108319690155686	0.438008654878292	17:60179093-60422470:-	USP32	14;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	ubiquitin specific peptidase 32 [Source:HGNC Symbol%3BAcc:HGNC:19143]
ENSG00000164116	5.83	6.64	7.50	5.82	6.56	4.92	0.220362887668271	3.69859356053517	0.108328894745538	0.438008654878292	4:155666710-155732349:+	GUCY1A3	23;GO:0000166,molecular_function nucleotide binding;GO:0004383,molecular_function guanylate cyclase activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006182,biological_process cGMP biosynthetic process;GO:0007263,biological_process nitric oxide mediated signal transduction;GO:0008015,biological_process blood circulation;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0008217,biological_process regulation of blood pressure;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0020037,molecular_function heme binding;GO:0030828,biological_process positive regulation of cGMP biosynthetic process;GO:0035556,biological_process intracellular signal transduction;GO:0052565,biological_process response to defense-related host nitric oxide production;GO:0060087,biological_process relaxation of vascular smooth muscle	GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]; K12318	guanylate cyclase 1 soluble subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:4685]
ENSG00000163328	2.81	1.87	2.68	2.12	2.24	1.72	0.306062887002126	2.59368677983394	0.108365560144354	0.438014229264689	2:174431570-174487094:-	GPR155	9;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035556,biological_process intracellular signal transduction;GO:0050890,biological_process cognition;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	NA	G protein-coupled receptor 155 [Source:HGNC Symbol%3BAcc:HGNC:22951]
ENSG00000009830	9.41	10.38	9.38	9.15	9.05	8.54	0.133018838694842	4.7108278470011	0.108580930972652	0.438732525203384	14:77274955-77320884:-	POMT2	15;GO:0000030,molecular_function mannosyltransferase activity;GO:0004169,molecular_function dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0035269,biological_process protein O-linked mannosylation;GO:0046872,molecular_function metal ion binding;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:0097502,biological_process mannosylation;GO:1904100,biological_process positive regulation of protein O-linked glycosylation	POMT, pmt; dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]; K00728	protein O-mannosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:19743]
ENSG00000164144	12.94	13.41	13.48	13.85	15.11	15.84	-0.160323453364713	3.99654646573044	0.108613957137678	0.438732525203384	4:152779936-152918463:+	ARFIP1	9;GO:0000139,cellular_component Golgi membrane;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0019904,molecular_function protein domain specific binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034315,biological_process regulation of Arp2/3 complex-mediated actin nucleation;GO:0045296,molecular_function cadherin binding;GO:0050708,biological_process regulation of protein secretion;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	ADP ribosylation factor interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21496]
ENSG00000172009	18.16	20.53	17.26	19.28	21.52	20.76	-0.130902463407478	5.58180574014601	0.108754508800902	0.438950306702286	19:2785459-2815807:+	THOP1	12;GO:0000209,biological_process protein polyubiquitination;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006518,biological_process peptide metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0042277,molecular_function peptide binding;GO:0046872,molecular_function metal ion binding	THOP1; thimet oligopeptidase [EC:3.4.24.15]; K01392	thimet oligopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:11793]
ENSG00000140450	10.70	6.93	11.03	11.17	10.40	12.79	-0.236044397571027	3.75094927095235	0.108782906178156	0.438950306702286	15:97960697-97973838:+	ARRDC4	7;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity	NA	arrestin domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:28087]
ENSG00000187098	12.26	11.92	12.36	9.00	12.14	11.54	0.173693286683107	4.3710113167809	0.108804069244839	0.438950306702286	3:69739434-69968337:+	MITF	25;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0007275,biological_process multicellular organism development;GO:0010628,biological_process positive regulation of gene expression;GO:0016925,biological_process protein sumoylation;GO:0030318,biological_process melanocyte differentiation;GO:0043234,cellular_component protein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0070888,molecular_function E-box binding;GO:2000144,biological_process positive regulation of DNA-templated transcription, initiation;GO:2001141,biological_process regulation of RNA biosynthetic process	MITF; microphthalmia-associated transcription factor; K09455	melanogenesis associated transcription factor [Source:HGNC Symbol%3BAcc:HGNC:7105]
ENSG00000109534	61.30	51.53	48.50	59.46	57.44	62.87	-0.141965679111946	5.21914839912666	0.108831944713065	0.438950306702286	4:109815509-109824740:+	GAR1	21;GO:0000454,biological_process snoRNA guided rRNA pseudouridine synthesis;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001522,biological_process pseudouridine synthesis;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0007004,biological_process telomere maintenance via telomerase;GO:0015030,cellular_component Cajal body;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031118,biological_process rRNA pseudouridine synthesis;GO:0031429,cellular_component box H/ACA snoRNP complex;GO:0034513,molecular_function box H/ACA snoRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0070034,molecular_function telomerase RNA binding;GO:0072589,cellular_component box H/ACA scaRNP complex;GO:0090661,cellular_component box H/ACA telomerase RNP complex	GAR1, NOLA1; H/ACA ribonucleoprotein complex subunit 1; K11128	GAR1 ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:14264]
ENSG00000103855	24.82	24.55	19.67	20.49	22.72	19.16	0.157023596783435	5.25239781978626	0.108878251161784	0.438950306702286	15:73683965-73714518:+	CD276	12;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0006955,biological_process immune response;GO:0008283,biological_process cell proliferation;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042110,biological_process T cell activation;GO:0045078,biological_process positive regulation of interferon-gamma biosynthetic process;GO:0050776,biological_process regulation of immune response;GO:0070062,cellular_component extracellular exosome	B7H3, CD276; immune costimulatory protein B7-H3; K06746	CD276 molecule [Source:HGNC Symbol%3BAcc:HGNC:19137]
ENSG00000159131	45.03	44.34	45.11	51.71	44.24	50.69	-0.113100345632957	7.18975665314666	0.108880044657725	0.438950306702286	21:33503930-33543491:-	GART	27;GO:0000166,molecular_function nucleotide binding;GO:0003360,biological_process brainstem development;GO:0003824,molecular_function catalytic activity;GO:0004637,molecular_function phosphoribosylamine-glycine ligase activity;GO:0004641,molecular_function phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644,molecular_function phosphoribosylglycinamide formyltransferase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006189,biological_process 'de novo' IMP biosynthetic process;GO:0006544,biological_process glycine metabolic process;GO:0008152,biological_process metabolic process;GO:0009058,biological_process biosynthetic process;GO:0009113,biological_process purine nucleobase biosynthetic process;GO:0009156,biological_process ribonucleoside monophosphate biosynthetic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0010033,biological_process response to organic substance;GO:0010035,biological_process response to inorganic substance;GO:0016740,molecular_function transferase activity;GO:0016742,molecular_function hydroxymethyl-, formyl- and related transferase activity;GO:0016874,molecular_function ligase activity;GO:0021549,biological_process cerebellum development;GO:0021987,biological_process cerebral cortex development;GO:0046654,biological_process tetrahydrofolate biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]; K11787	phosphoribosylglycinamide formyltransferase%2C phosphoribosylglycinamide synthetase%2C phosphoribosylaminoimidazole synthetase [Source:HGNC Symbol%3BAcc:HGNC:4163]
ENSG00000160688	10.53	9.52	9.65	9.18	8.24	9.54	0.153885584410004	4.25116748247342	0.109028041402413	0.43940424608057	1:154983337-154993111:+	FLAD1	16;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003919,molecular_function FMN adenylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006747,biological_process FAD biosynthetic process;GO:0006771,biological_process riboflavin metabolic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0055114,biological_process oxidation-reduction process	FLAD1; FAD synthetase [EC:2.7.7.2]; K00953	flavin adenine dinucleotide synthetase 1 [Source:HGNC Symbol%3BAcc:HGNC:24671]
ENSG00000104824	113.42	125.13	112.01	127.23	136.19	119.35	-0.115824483828497	7.91444607756548	0.1091132292999	0.439604841057989	19:38836387-38852347:-	HNRNPL	19;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035770,cellular_component ribonucleoprotein granule;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045120,cellular_component pronucleus;GO:0070062,cellular_component extracellular exosome;GO:0097157,molecular_function pre-mRNA intronic binding	NA	heterogeneous nuclear ribonucleoprotein L [Source:HGNC Symbol%3BAcc:HGNC:5045]
ENSG00000166855	23.02	24.46	24.03	21.37	22.17	23.11	0.110863750104958	5.45505984067178	0.109162190089567	0.439659398306878	15:65148218-65185342:-	CLPX	20;GO:0000166,molecular_function nucleotide binding;GO:0004176,molecular_function ATP-dependent peptidase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0009368,cellular_component endopeptidase Clp complex;GO:0009841,cellular_component mitochondrial endopeptidase Clp complex;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016504,molecular_function peptidase activator activity;GO:0016887,molecular_function ATPase activity;GO:0042645,cellular_component mitochondrial nucleoid;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051082,molecular_function unfolded protein binding;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process	NA	caseinolytic mitochondrial matrix peptidase chaperone subunit [Source:HGNC Symbol%3BAcc:HGNC:2088]
ENSG00000050130	68.61	72.75	74.20	69.22	67.10	65.58	0.105486419205735	6.09472643451486	0.109240377535222	0.439817910532166	14:59484442-59505410:+	JKAMP	7;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding	NA	JNK1/MAPK8-associated membrane protein [Source:HGNC Symbol%3BAcc:HGNC:20184]
ENSG00000106258	4.10	3.18	4.41	3.26	3.71	2.76	0.291344156565989	2.60351729770409	0.109273599382281	0.439817910532166	7:99648193-99679998:-	CYP3A5	23;GO:0002933,biological_process lipid hydroxylation;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006805,biological_process xenobiotic metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0009822,biological_process alkaloid catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016712,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0019825,molecular_function oxygen binding;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0042737,biological_process drug catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070330,molecular_function aromatase activity;GO:0070989,biological_process oxidative demethylation;GO:0101020,molecular_function estrogen 16-alpha-hydroxylase activity	CYP3A; cytochrome P450 family 3 subfamily A [EC:1.14.14.1]; K07424	cytochrome P450 family 3 subfamily A member 5 [Source:HGNC Symbol%3BAcc:HGNC:2638]
ENSG00000103275	192.98	200.64	195.11	216.80	207.73	211.18	-0.0997836500661425	6.9695095100666	0.109342898967313	0.439817910532166	16:1308879-1327018:+	UBE2I	44;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000795,cellular_component synaptonemal complex;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0010469,biological_process regulation of receptor activity;GO:0016032,biological_process viral process;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0019899,molecular_function enzyme binding;GO:0030425,cellular_component dendrite;GO:0033145,biological_process positive regulation of intracellular steroid hormone receptor signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043398,molecular_function HLH domain binding;GO:0043425,molecular_function bHLH transcription factor binding;GO:0044388,molecular_function small protein activating enzyme binding;GO:0045202,cellular_component synapse;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051301,biological_process cell division;GO:0061656,molecular_function SUMO conjugating enzyme activity;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0071535,molecular_function RING-like zinc finger domain binding;GO:1903755,biological_process positive regulation of SUMO transferase activity;GO:1990234,cellular_component transferase complex;GO:1990356,cellular_component sumoylated E2 ligase complex	UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I; K10577	ubiquitin conjugating enzyme E2 I [Source:HGNC Symbol%3BAcc:HGNC:12485]
ENSG00000114796	16.67	16.06	16.84	14.57	16.23	15.00	0.12858925501551	4.85393675028329	0.109343274945804	0.439817910532166	3:183635567-183684477:+	KLHL24	14;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005912,cellular_component adherens junction;GO:0016567,biological_process protein ubiquitination;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0030424,cellular_component axon;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042995,cellular_component cell projection;GO:0043204,cellular_component perikaryon;GO:0045109,biological_process intermediate filament organization;GO:0051865,biological_process protein autoubiquitination;GO:2000312,biological_process regulation of kainate selective glutamate receptor activity	NA	kelch like family member 24 [Source:HGNC Symbol%3BAcc:HGNC:25947]
ENSG00000179242	1.54	1.20	1.76	2.06	1.90	1.66	-0.28802147541296	2.2953889984773	0.109432613292923	0.440034670814723	20:61252425-61940617:+	CDH4	12;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034332,biological_process adherens junction organization;GO:0045773,biological_process positive regulation of axon extension;GO:0046872,molecular_function metal ion binding	CDH4; cadherin 4, type 1, R-cadherin; K06797	cadherin 4 [Source:HGNC Symbol%3BAcc:HGNC:1763]
ENSG00000204130	7.12	6.78	8.06	6.29	7.19	6.24	0.173680815135241	4.01934193771489	0.109506426740509	0.440188884433271	10:68341106-68407294:-	RUFY2	2;GO:0005634,cellular_component nucleus;GO:0046872,molecular_function metal ion binding	NA	RUN and FYVE domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:19761]
ENSG00000134905	20.22	21.52	20.63	18.38	21.22	17.82	0.129684499023665	5.33226440657315	0.109554980541747	0.440241493513986	13:110641411-110713603:-	CARS2	12;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004817,molecular_function cysteine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006423,biological_process cysteinyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity;GO:0046872,molecular_function metal ion binding	CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]; K01883	cysteinyl-tRNA synthetase 2%2C mitochondrial (putative) [Source:HGNC Symbol%3BAcc:HGNC:25695]
ENSG00000278535	10.96	8.70	11.51	9.22	10.02	7.03	0.272820380371486	2.93292231061324	0.109626241918024	0.440270210429612	17:36591797-36600806:+	DHRS11	3;GO:0005576,cellular_component extracellular region;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	dehydrogenase/reductase 11 [Source:HGNC Symbol%3BAcc:HGNC:28639]
ENSG00000150347	5.72	7.47	5.69	4.53	6.42	5.42	0.211229365856281	4.39188713119055	0.109633063758796	0.440270210429612	10:61901299-62096944:+	ARID5B	34;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001822,biological_process kidney development;GO:0001889,biological_process liver development;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006807,biological_process nitrogen compound metabolic process;GO:0008584,biological_process male gonad development;GO:0008585,biological_process female gonad development;GO:0009791,biological_process post-embryonic development;GO:0010761,biological_process fibroblast migration;GO:0016577,biological_process histone demethylation;GO:0030325,biological_process adrenal gland development;GO:0032452,molecular_function histone demethylase activity;GO:0035264,biological_process multicellular organism growth;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045444,biological_process fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048468,biological_process cell development;GO:0048644,biological_process muscle organ morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis;GO:0060612,biological_process adipose tissue development;GO:0060613,biological_process fat pad development;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	AT-rich interaction domain 5B [Source:HGNC Symbol%3BAcc:HGNC:17362]
ENSG00000113790	17.00	18.95	16.25	18.36	20.64	18.54	-0.13312370256727	5.34747271659823	0.109751877401446	0.440356221438366	3:185190623-185281990:-	EHHADH	22;GO:0003824,molecular_function catalytic activity;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0004165,molecular_function dodecenoyl-CoA delta-isomerase activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0005829,cellular_component cytosol;GO:0006475,biological_process internal protein amino acid acetylation;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016508,molecular_function long-chain-enoyl-CoA hydratase activity;GO:0016829,molecular_function lyase activity;GO:0016853,molecular_function isomerase activity;GO:0019899,molecular_function enzyme binding;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0055114,biological_process oxidation-reduction process	EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]; K07514	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:3247]
ENSG00000198055	24.84	24.28	22.07	25.50	26.17	26.03	-0.1156148207537	5.47995800221364	0.109756837110239	0.440356221438366	5:177403203-177442901:+	GRK6	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004703,molecular_function G-protein coupled receptor kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0047696,molecular_function beta-adrenergic receptor kinase activity	GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]; K08291	G protein-coupled receptor kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:4545]
ENSG00000185721	52.67	52.06	52.27	62.48	53.49	55.44	-0.114708144311928	6.2722170915797	0.109760907849054	0.440356221438366	22:31399522-31530634:+	DRG1	12;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006351,biological_process transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0042802,molecular_function identical protein binding	NA	developmentally regulated GTP binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3029]
ENSG00000132825	3.15	3.94	2.95	2.09	2.62	2.98	0.375158897529546	1.47335595554779	0.109826747828415	0.440478003487598	20:59936667-59940297:-	PPP1R3D	10;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005979,biological_process regulation of glycogen biosynthetic process;GO:0005981,biological_process regulation of glycogen catabolic process;GO:0006470,biological_process protein dephosphorylation;GO:0019899,molecular_function enzyme binding;GO:0042587,cellular_component glycogen granule;GO:0043231,cellular_component intracellular membrane-bounded organelle	PPP1R3; protein phosphatase 1 regulatory subunit 3A/B/C/D/E; K07189	protein phosphatase 1 regulatory subunit 3D [Source:HGNC Symbol%3BAcc:HGNC:9294]
ENSG00000111224	7.08	7.09	6.81	7.93	8.18	8.26	-0.207149460360792	3.00263209263453	0.109969932686172	0.44090981086352	12:3791046-3873448:-	PARP11	13;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0006810,biological_process transport;GO:0006998,biological_process nuclear envelope organization;GO:0007283,biological_process spermatogenesis;GO:0015031,biological_process protein transport;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030154,biological_process cell differentiation;GO:0051028,biological_process mRNA transport	NA	poly(ADP-ribose) polymerase family member 11 [Source:HGNC Symbol%3BAcc:HGNC:1186]
ENSG00000168291	54.08	61.88	51.07	47.64	53.77	52.39	0.127196616969139	6.06542132497059	0.11006111158581	0.440926853974558	3:58427629-58433857:-	PDHB	22;GO:0003824,molecular_function catalytic activity;GO:0004738,molecular_function pyruvate dehydrogenase activity;GO:0004739,molecular_function pyruvate dehydrogenase (acetyl-transferring) activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006086,biological_process acetyl-CoA biosynthetic process from pyruvate;GO:0006090,biological_process pyruvate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0008152,biological_process metabolic process;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016491,molecular_function oxidoreductase activity;GO:0034604,molecular_function pyruvate dehydrogenase (NAD+) activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0045254,cellular_component pyruvate dehydrogenase complex;GO:0055114,biological_process oxidation-reduction process;GO:0061732,biological_process mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:0070062,cellular_component extracellular exosome	PDHB, pdhB; pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]; K00162	pyruvate dehydrogenase (lipoamide) beta [Source:HGNC Symbol%3BAcc:HGNC:8808]
ENSG00000051620	40.52	35.74	39.62	41.40	41.20	45.14	-0.124386347312558	5.06965257139242	0.110132794221708	0.440926853974558	6:138403530-138422197:+	HEBP2	10;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0010917,biological_process negative regulation of mitochondrial membrane potential;GO:0010940,biological_process positive regulation of necrotic cell death;GO:0035578,cellular_component azurophil granule lumen;GO:0035794,biological_process positive regulation of mitochondrial membrane permeability;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	heme binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15716]
ENSG00000153790	7.54	6.21	8.07	8.93	7.76	8.46	-0.182278825939899	3.8163144480145	0.110139063582263	0.440926853974558	7:25134696-25180356:-	C7orf31	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton	NA	chromosome 7 open reading frame 31 [Source:HGNC Symbol%3BAcc:HGNC:21722]
ENSG00000124795	138.61	149.85	133.79	146.05	157.84	154.34	-0.107301233277785	7.52886889280628	0.110146263508726	0.440926853974558	6:18223867-18264823:-	DEK	16;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0016569,biological_process covalent chromatin modification;GO:0019079,biological_process viral genome replication;GO:0042393,molecular_function histone binding;GO:0043292,cellular_component contractile fiber;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:2000779,biological_process regulation of double-strand break repair;GO:2001032,biological_process regulation of double-strand break repair via nonhomologous end joining	NA	DEK proto-oncogene [Source:HGNC Symbol%3BAcc:HGNC:2768]
ENSG00000143093	15.80	14.23	13.91	12.75	13.57	14.28	0.127443813516554	5.18338284187718	0.110183927445026	0.440926853974558	1:110031576-110074641:+	STRIP1	8;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0070062,cellular_component extracellular exosome	NA	striatin interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:25916]
ENSG00000147140	534.97	544.45	540.84	580.48	578.24	578.07	-0.0884796520187702	9.62789120469664	0.110187311772261	0.440926853974558	X:71283191-71301168:+	NONO	30;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007623,biological_process circadian rhythm;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0042382,cellular_component paraspeckles;GO:0042752,biological_process regulation of circadian rhythm;GO:0042802,molecular_function identical protein binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1903377,biological_process negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	NA	non-POU domain containing octamer binding [Source:HGNC Symbol%3BAcc:HGNC:7871]
ENSG00000165312	12.28	10.93	13.36	10.12	9.46	12.67	0.19648850674282	4.06666689306553	0.110252762571568	0.441046581308693	10:23439457-23442390:+	OTUD1	7;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0070536,biological_process protein K63-linked deubiquitination	NA	OTU deubiquitinase 1 [Source:HGNC Symbol%3BAcc:HGNC:27346]
ENSG00000105701	217.38	203.74	204.71	197.06	196.06	197.82	0.0948996131506255	7.99696315080225	0.110331129105446	0.441083967621451	19:18531750-18544077:-	FKBP8	34;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0001708,biological_process cell fate specification;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005528,molecular_function FK506 binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007224,biological_process smoothened signaling pathway;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016853,molecular_function isomerase activity;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021915,biological_process neural tube development;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030510,biological_process regulation of BMP signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0031966,cellular_component mitochondrial membrane;GO:0035264,biological_process multicellular organism growth;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0043010,biological_process camera-type eye development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0097718,molecular_function disordered domain specific binding	NA	FK506 binding protein 8 [Source:HGNC Symbol%3BAcc:HGNC:3724]
ENSG00000121236	4.74	5.86	4.56	5.66	6.86	5.45	-0.242999607648813	3.11684919765912	0.110352445379105	0.441083967621451	11:5596108-5612958:+	TRIM6	32;GO:0000209,biological_process protein polyubiquitination;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002741,biological_process positive regulation of cytokine secretion involved in immune response;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010994,biological_process free ubiquitin chain polymerization;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030674,molecular_function protein binding, bridging;GO:0032496,biological_process response to lipopolysaccharide;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035458,biological_process cellular response to interferon-beta;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070206,biological_process protein trimerization;GO:0098586,biological_process cellular response to virus;GO:1990782,molecular_function protein tyrosine kinase binding;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding;GO:2000737,biological_process negative regulation of stem cell differentiation	NA	tripartite motif containing 6 [Source:HGNC Symbol%3BAcc:HGNC:16277]
ENSG00000177192	15.99	14.05	13.22	16.90	14.51	17.34	-0.159275031114446	4.5721500752918	0.110368710499656	0.441083967621451	12:131929199-131945896:+	PUS1	13;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0004730,molecular_function pseudouridylate synthase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity;GO:0031119,biological_process tRNA pseudouridine synthesis;GO:0070902,biological_process mitochondrial tRNA pseudouridine synthesis;GO:1990481,biological_process mRNA pseudouridine synthesis	NA	pseudouridylate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:15508]
ENSG00000214102	0.71	0.45	0.61	0.26	0.27	0.58	0.679051110049089	-0.0364935446183836	0.110599795347649	0.441831193783692	7:141708352-141731271:+	WEE2	23;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007143,biological_process female meiotic division;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0035038,biological_process female pronucleus assembly;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0046872,molecular_function metal ion binding;GO:0051321,biological_process meiotic cell cycle;GO:0060631,biological_process regulation of meiosis I;GO:1900194,biological_process negative regulation of oocyte maturation	WEE1; wee1-like protein kinase [EC:2.7.11.1]; K06632	WEE1 homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:19684]
ENSG00000103269	2.09	1.70	2.45	2.88	2.02	3.33	-0.376630789292235	1.78780236446874	0.11063381754921	0.441831193783692	16:675665-678268:+	RHBDL1	10;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity	NA	rhomboid like 1 [Source:HGNC Symbol%3BAcc:HGNC:10007]
ENSG00000168487	32.19	27.89	32.69	30.06	27.11	28.98	0.120902618617307	6.65432790337984	0.110662465276202	0.441831193783692	8:22164735-22212326:+	BMP1	26;GO:0001501,biological_process skeletal system development;GO:0001502,biological_process cartilage condensation;GO:0001503,biological_process ossification;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005125,molecular_function cytokine activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0006508,biological_process proteolysis;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030154,biological_process cell differentiation;GO:0031982,cellular_component vesicle;GO:0034380,biological_process high-density lipoprotein particle assembly;GO:0046872,molecular_function metal ion binding;GO:0051216,biological_process cartilage development;GO:0061036,biological_process positive regulation of cartilage development	NA	bone morphogenetic protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1067]
ENSG00000119632	57.04	57.83	50.20	51.45	51.34	47.06	0.148923973963951	4.36354766907849	0.110712136262307	0.441887378592931	14:94127778-94130253:-	IFI27L2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	interferon alpha inducible protein 27 like 2 [Source:HGNC Symbol%3BAcc:HGNC:19753]
ENSG00000159958	1.15	1.56	2.53	2.58	2.75	2.42	-0.54015992138985	0.438371198161479	0.110871119240471	0.442338392857956	22:41922022-41926818:-	TNFRSF13C	15;GO:0001782,biological_process B cell homeostasis;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002636,biological_process positive regulation of germinal center formation;GO:0005886,cellular_component plasma membrane;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031295,biological_process T cell costimulation;GO:0031296,biological_process B cell costimulation;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0045078,biological_process positive regulation of interferon-gamma biosynthetic process;GO:0050776,biological_process regulation of immune response	TNFRSF13C, BAFFR, CD268; tumor necrosis factor receptor superfamily member 13C; K05151	TNF receptor superfamily member 13C [Source:HGNC Symbol%3BAcc:HGNC:17755]
ENSG00000076864	2.28	2.05	1.52	2.41	2.81	2.07	-0.30405537919065	2.50131124460519	0.110950294593299	0.442338392857956	1:21596214-21669363:-	RAP1GAP	25;GO:0000139,cellular_component Golgi membrane;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0017016,molecular_function Ras GTPase binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030695,molecular_function GTPase regulator activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0050790,biological_process regulation of catalytic activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:1903697,biological_process negative regulation of microvillus assembly;GO:1904425,biological_process negative regulation of GTP binding;GO:1904442,biological_process negative regulation of thyroid gland epithelial cell proliferation;GO:1990792,biological_process cellular response to glial cell derived neurotrophic factor	NA	RAP1 GTPase activating protein [Source:HGNC Symbol%3BAcc:HGNC:9858]
ENSG00000074201	92.87	85.45	91.06	106.39	90.69	97.65	-0.116155922649073	6.1374422604092	0.110987348841592	0.442338392857956	11:77514935-77637805:-	CLNS1A	14;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006821,biological_process chloride transport;GO:0006884,biological_process cell volume homeostasis;GO:0034709,cellular_component methylosome;GO:0034715,cellular_component pICln-Sm protein complex;GO:0046982,molecular_function protein heterodimerization activity	CLNS1A; chloride channel, nucleotide-sensitive, 1A; K05019	chloride nucleotide-sensitive channel 1A [Source:HGNC Symbol%3BAcc:HGNC:2080]
ENSG00000162616	29.83	28.07	27.08	23.55	27.16	27.20	0.137755281414464	4.78701844791209	0.111000658427646	0.442338392857956	1:77979174-78017964:+	DNAJB4	13;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006986,biological_process response to unfolded protein;GO:0009408,biological_process response to heat;GO:0016020,cellular_component membrane;GO:0032781,biological_process positive regulation of ATPase activity;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0070062,cellular_component extracellular exosome	NA	DnaJ heat shock protein family (Hsp40) member B4 [Source:HGNC Symbol%3BAcc:HGNC:14886]
ENSG00000053747	66.49	69.61	68.76	61.74	67.95	63.15	0.0989048789365613	9.44826102545719	0.111003310541572	0.442338392857956	18:23689442-23955066:+	LAMA3	16;GO:0005102,molecular_function receptor binding;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005610,cellular_component laminin-5 complex;GO:0007155,biological_process cell adhesion;GO:0008544,biological_process epidermis development;GO:0022617,biological_process extracellular matrix disassembly;GO:0030155,biological_process regulation of cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030334,biological_process regulation of cell migration;GO:0031581,biological_process hemidesmosome assembly;GO:0035987,biological_process endodermal cell differentiation;GO:0045995,biological_process regulation of embryonic development;GO:0070062,cellular_component extracellular exosome	LAMA3_5; laminin, alpha 3/5; K06240	laminin subunit alpha 3 [Source:HGNC Symbol%3BAcc:HGNC:6483]
ENSG00000139193	16.48	12.99	16.89	17.28	17.99	18.21	-0.181452269554529	3.72398926488406	0.111046464914753	0.442368346914902	12:6444866-6451718:+	CD27	31;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008588,biological_process release of cytoplasmic sequestered NF-kappaB;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016064,biological_process immunoglobulin mediated immune response;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045471,biological_process response to ethanol;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0046330,biological_process positive regulation of JNK cascade;GO:0070062,cellular_component extracellular exosome;GO:0070233,biological_process negative regulation of T cell apoptotic process;GO:0097191,biological_process extrinsic apoptotic signaling pathway	TNFRSF7, CD27; tumor necrosis factor receptor superfamily member 7; K05144	CD27 molecule [Source:HGNC Symbol%3BAcc:HGNC:11922]
ENSG00000196418	3.77	5.91	3.38	3.16	3.98	2.97	0.360841419332155	2.06780712263784	0.111273293557054	0.443129557374719	1:247121974-247172016:-	ZNF124	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 124 [Source:HGNC Symbol%3BAcc:HGNC:12907]
ENSG00000185745	23.94	28.46	22.99	18.48	25.28	23.29	0.176396862178151	5.09154407186772	0.111347016623918	0.443129557374719	10:89392545-89406486:+	IFIT1	20;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009615,biological_process response to virus;GO:0016032,biological_process viral process;GO:0019060,biological_process intracellular transport of viral protein in host cell;GO:0032091,biological_process negative regulation of protein binding;GO:0043657,cellular_component host cell;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0050688,biological_process regulation of defense response to virus;GO:0050689,biological_process negative regulation of defense response to virus by host;GO:0051097,biological_process negative regulation of helicase activity;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0071357,biological_process cellular response to type I interferon;GO:0071360,biological_process cellular response to exogenous dsRNA	IFIT1; interferon-induced protein with tetratricopeptide repeats 1; K14217	interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol%3BAcc:HGNC:5407]
ENSG00000119760	43.56	43.20	49.81	50.85	50.30	48.21	-0.115181528990902	5.90224895611118	0.111361931026333	0.443129557374719	2:27650811-27663840:-	SUPT7L	10;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030914,cellular_component STAGA complex;GO:0043966,biological_process histone H3 acetylation;GO:0051457,biological_process maintenance of protein location in nucleus	NA	SPT7 like%2C STAGA complex gamma subunit [Source:HGNC Symbol%3BAcc:HGNC:30632]
ENSG00000005961	0.91	0.80	1.09	0.77	0.68	0.74	0.369178458380345	1.45856359013298	0.111390137213849	0.443129557374719	17:44372179-44389505:-	ITGA2B	24;GO:0002576,biological_process platelet degranulation;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0031092,cellular_component platelet alpha granule membrane;GO:0042802,molecular_function identical protein binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0050840,molecular_function extracellular matrix binding;GO:0070051,molecular_function fibrinogen binding;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0072562,cellular_component blood microparticle	ITGA2B, CD41; integrin alpha 2B; K06476	integrin subunit alpha 2b [Source:HGNC Symbol%3BAcc:HGNC:6138]
ENSG00000181322	1.81	1.34	1.76	1.11	1.63	0.87	0.478768352532912	0.90673716203022	0.111416043548417	0.443129557374719	3:138261436-138329886:-	NME9	10;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005622,cellular_component intracellular;GO:0005623,cellular_component cell;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006183,biological_process GTP biosynthetic process;GO:0006228,biological_process UTP biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0045454,biological_process cell redox homeostasis	NA	NME/NM23 family member 9 [Source:HGNC Symbol%3BAcc:HGNC:21343]
ENSG00000147535	15.89	14.37	11.66	11.26	12.71	12.51	0.211188616176319	3.52628677016467	0.111453248757491	0.443135546709395	8:38263129-38269243:-	PLPP5	10;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006644,biological_process phospholipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046839,biological_process phospholipid dephosphorylation	NA	phospholipid phosphatase 5 [Source:HGNC Symbol%3BAcc:HGNC:25026]
ENSG00000214022	59.60	60.57	56.14	52.82	57.71	54.72	0.104600003571867	6.97331392958883	0.111668265251986	0.443436650389211	7:150368188-150374044:+	REPIN1	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0006260,biological_process DNA replication;GO:0046872,molecular_function metal ion binding	NA	replication initiator 1 [Source:HGNC Symbol%3BAcc:HGNC:17922]
ENSG00000140854	7.55	7.07	6.90	7.97	8.47	7.75	-0.153781413195223	3.9942873475198	0.111704648886451	0.443436650389211	16:57735729-57757250:+	KATNB1	28;GO:0000922,cellular_component spindle pole;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006605,biological_process protein targeting;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008352,cellular_component katanin complex;GO:0008568,molecular_function microtubule-severing ATPase activity;GO:0010942,biological_process positive regulation of cell death;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0031117,biological_process positive regulation of microtubule depolymerization;GO:0043025,cellular_component neuronal cell body;GO:0046982,molecular_function protein heterodimerization activity;GO:0051013,biological_process microtubule severing;GO:0051301,biological_process cell division;GO:0070840,molecular_function dynein complex binding	NA	katanin regulatory subunit B1 [Source:HGNC Symbol%3BAcc:HGNC:6217]
ENSG00000183780	2.79	3.46	3.38	2.95	2.50	2.50	0.277628984153489	2.21861683433219	0.111755742087991	0.443436650389211	1:233904932-234324516:+	SLC35F3	4;GO:0006810,biological_process transport;GO:0015888,biological_process thiamine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member F3 [Source:HGNC Symbol%3BAcc:HGNC:23616]
ENSG00000138036	26.64	29.82	28.06	30.75	30.54	30.77	-0.11586386004394	5.45960277596087	0.111765974752965	0.443436650389211	2:43774038-43810010:+	DYNC2LI1	28;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0030030,biological_process cell projection organization;GO:0030286,cellular_component dynein complex;GO:0030990,cellular_component intraciliary transport particle;GO:0031514,cellular_component motile cilium;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045177,cellular_component apical part of cell;GO:0045504,molecular_function dynein heavy chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip;GO:1902017,biological_process regulation of cilium assembly	DYNC2LI; dynein light intermediate chain 2, cytosolic; K10417	dynein cytoplasmic 2 light intermediate chain 1 [Source:HGNC Symbol%3BAcc:HGNC:24595]
ENSG00000145362	1.38	0.74	1.51	1.55	1.32	1.63	-0.284910094665334	4.14509538698127	0.111780082345042	0.443436650389211	4:112818108-113383740:+	ANK2	72;GO:0002027,biological_process regulation of heart rate;GO:0003283,biological_process atrial septum development;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0010628,biological_process positive regulation of gene expression;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010882,biological_process regulation of cardiac muscle contraction by calcium ion signaling;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030315,cellular_component T-tubule;GO:0030507,molecular_function spectrin binding;GO:0030674,molecular_function protein binding, bridging;GO:0030913,biological_process paranodal junction assembly;GO:0031430,cellular_component M band;GO:0031647,biological_process regulation of protein stability;GO:0031672,cellular_component A band;GO:0033292,biological_process T-tubule organization;GO:0033365,biological_process protein localization to organelle;GO:0034394,biological_process protein localization to cell surface;GO:0034613,biological_process cellular protein localization;GO:0036309,biological_process protein localization to M-band;GO:0036371,biological_process protein localization to T-tubule;GO:0042383,cellular_component sarcolemma;GO:0043005,cellular_component neuron projection;GO:0043034,cellular_component costamere;GO:0043268,biological_process positive regulation of potassium ion transport;GO:0044325,molecular_function ion channel binding;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0050821,biological_process protein stabilization;GO:0051117,molecular_function ATPase binding;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0051597,biological_process response to methylmercury;GO:0051924,biological_process regulation of calcium ion transport;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0060307,biological_process regulation of ventricular cardiac muscle cell membrane repolarization;GO:0070296,biological_process sarcoplasmic reticulum calcium ion transport;GO:0070972,biological_process protein localization to endoplasmic reticulum;GO:0072659,biological_process protein localization to plasma membrane;GO:0072661,biological_process protein targeting to plasma membrane;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:0086005,biological_process ventricular cardiac muscle cell action potential;GO:0086014,biological_process atrial cardiac muscle cell action potential;GO:0086015,biological_process SA node cell action potential;GO:0086046,biological_process membrane depolarization during SA node cell action potential;GO:0086066,biological_process atrial cardiac muscle cell to AV node cell communication;GO:0086070,biological_process SA node cell to atrial cardiac muscle cell communication;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0098907,biological_process regulation of SA node cell action potential;GO:0098910,biological_process regulation of atrial cardiac muscle cell action potential;GO:1901018,biological_process positive regulation of potassium ion transmembrane transporter activity;GO:1901019,biological_process regulation of calcium ion transmembrane transporter activity;GO:1901021,biological_process positive regulation of calcium ion transmembrane transporter activity;GO:2001259,biological_process positive regulation of cation channel activity	ANK; ankyrin; K10380	ankyrin 2 [Source:HGNC Symbol%3BAcc:HGNC:493]
ENSG00000184164	19.91	23.53	19.71	14.96	22.45	17.73	0.204105784525698	4.57504458685401	0.111808461175785	0.443436650389211	22:49918166-49927540:+	CRELD2	6;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus	NA	cysteine rich with EGF like domains 2 [Source:HGNC Symbol%3BAcc:HGNC:28150]
ENSG00000181045	0.47	0.39	0.68	0.69	0.82	0.76	-0.515355134335357	0.490887618203058	0.111818064728356	0.443436650389211	17:80219698-80253500:+	SLC26A11	28;GO:0005254,molecular_function chloride channel activity;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008271,molecular_function secondary active sulfate transmembrane transporter activity;GO:0008272,biological_process sulfate transport;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0015106,molecular_function bicarbonate transmembrane transporter activity;GO:0015116,molecular_function sulfate transmembrane transporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019531,molecular_function oxalate transmembrane transporter activity;GO:0019532,biological_process oxalate transport;GO:0042391,biological_process regulation of membrane potential;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1902358,biological_process sulfate transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 26 member 11 [Source:HGNC Symbol%3BAcc:HGNC:14471]
ENSG00000103091	18.93	18.43	19.07	20.07	20.06	20.89	-0.100168579891318	5.89530111388633	0.111836489395426	0.443436650389211	16:74871366-75000173:-	WDR59	10;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0032008,biological_process positive regulation of TOR signaling;GO:0034198,biological_process cellular response to amino acid starvation;GO:0061700,cellular_component GATOR2 complex	NA	WD repeat domain 59 [Source:HGNC Symbol%3BAcc:HGNC:25706]
ENSG00000204954	21.42	19.84	20.31	21.89	24.66	25.17	-0.205222912856343	3.05550940436188	0.111850491611103	0.443436650389211	12:103950201-103965708:-	C12orf73	1;GO:0005576,cellular_component extracellular region	NA	chromosome 12 open reading frame 73 [Source:HGNC Symbol%3BAcc:HGNC:34450]
ENSG00000106261	28.02	27.16	30.29	28.15	25.42	25.85	0.119859306942972	5.54243169104493	0.111986941503223	0.443576764812132	7:100015571-100041689:+	ZKSCAN1	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger with KRAB and SCAN domains 1 [Source:HGNC Symbol%3BAcc:HGNC:13101]
ENSG00000134900	15.50	17.64	16.82	14.71	16.27	15.49	0.113445401918976	5.92981144859878	0.112008285982224	0.443576764812132	13:102597002-102679958:+	TPP2	16;GO:0000209,biological_process protein polyubiquitination;GO:0004175,molecular_function endopeptidase activity;GO:0004177,molecular_function aminopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008240,molecular_function tripeptidyl-peptidase activity;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0042277,molecular_function peptide binding	NA	tripeptidyl peptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:12016]
ENSG00000115504	37.40	33.57	36.91	34.29	32.19	34.58	0.107379426023984	7.01318740575074	0.11203170518253	0.443576764812132	2:62673850-63046487:+	EHBP1	8;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane	NA	EH domain binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29144]
ENSG00000177125	4.34	3.54	3.70	3.07	2.96	3.72	0.265259073129111	2.47118375411406	0.112038117258972	0.443576764812132	9:126860664-126885878:+	ZBTB34	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 34 [Source:HGNC Symbol%3BAcc:HGNC:31446]
ENSG00000188807	4.53	4.89	4.30	3.90	4.32	3.77	0.20124352144757	3.16909524104633	0.112064507729868	0.443576764812132	1:9588921-9614873:+	TMEM201	12;GO:0000922,cellular_component spindle pole;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007097,biological_process nuclear migration;GO:0010761,biological_process fibroblast migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0051015,molecular_function actin filament binding	NA	transmembrane protein 201 [Source:HGNC Symbol%3BAcc:HGNC:33719]
ENSG00000181704	52.27	57.64	56.76	49.07	50.45	54.72	0.119704095217573	5.24793193444332	0.112135356320276	0.44371570863997	X:68498322-68537285:+	YIPF6	9;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0042802,molecular_function identical protein binding;GO:0060576,biological_process intestinal epithelial cell development	NA	Yip1 domain family member 6 [Source:HGNC Symbol%3BAcc:HGNC:28304]
ENSG00000136861	17.42	16.88	17.51	19.35	18.12	18.56	-0.100580494982896	6.71495002679451	0.112324144837837	0.444270356576984	9:120388868-120580170:-	CDK5RAP2	39;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000242,cellular_component pericentriolar material;GO:0000922,cellular_component spindle pole;GO:0001578,biological_process microtubule bundle formation;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007059,biological_process chromosome segregation;GO:0007098,biological_process centrosome cycle;GO:0007099,biological_process centriole replication;GO:0007420,biological_process brain development;GO:0008017,molecular_function microtubule binding;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0022008,biological_process neurogenesis;GO:0030054,cellular_component cell junction;GO:0031023,biological_process microtubule organizing center organization;GO:0035371,cellular_component microtubule plus-end;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045664,biological_process regulation of neuron differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046600,biological_process negative regulation of centriole replication;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0090231,biological_process regulation of spindle checkpoint;GO:0097431,cellular_component mitotic spindle pole;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	CDK5 regulatory subunit associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18672]
ENSG00000180233	3.89	3.16	2.74	3.82	4.18	4.75	-0.363840990812201	1.53531434184671	0.112356642332534	0.444270356576984	7:30284306-30367692:+	ZNRF2	21;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0042734,cellular_component presynaptic membrane;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	zinc and ring finger 2 [Source:HGNC Symbol%3BAcc:HGNC:22316]
ENSG00000116903	7.50	6.99	5.92	5.40	6.21	6.40	0.190073723373388	3.81441150094213	0.112393075008012	0.444270356576984	1:231332752-231337852:-	EXOC8	20;GO:0000145,cellular_component exocyst;GO:0001927,biological_process exocyst assembly;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0007032,biological_process endosome organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0017160,molecular_function Ral GTPase binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030426,cellular_component growth cone;GO:0034613,biological_process cellular protein localization;GO:0042995,cellular_component cell projection;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051601,biological_process exocyst localization	NA	exocyst complex component 8 [Source:HGNC Symbol%3BAcc:HGNC:24659]
ENSG00000120451	13.62	13.32	14.00	12.63	12.87	12.80	0.109234526020543	5.3478516321103	0.11241868927804	0.444270356576984	11:130875435-130916509:-	SNX19	16;GO:0002062,biological_process chondrocyte differentiation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030073,biological_process insulin secretion;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:1990502,biological_process dense core granule maturation	NA	sorting nexin 19 [Source:HGNC Symbol%3BAcc:HGNC:21532]
ENSG00000170017	180.40	180.76	168.95	154.54	171.71	171.17	0.103421008962962	8.22890795074988	0.112455174485804	0.444273100220331	3:105366908-105576900:+	ALCAM	27;GO:0001772,cellular_component immunological synapse;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0008045,biological_process motor neuron axon guidance;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0042101,cellular_component T cell receptor complex;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0048846,biological_process axon extension involved in axon guidance;GO:0070062,cellular_component extracellular exosome;GO:1990138,biological_process neuron projection extension	ALCAM, CD166; activated leukocyte cell adhesion molecule; K06547	activated leukocyte cell adhesion molecule [Source:HGNC Symbol%3BAcc:HGNC:400]
ENSG00000144354	24.69	19.25	20.83	25.07	22.58	24.95	-0.146753688634328	4.96258071495654	0.112512870687215	0.444359613057717	2:173354819-173368997:+	CDCA7	8;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0042127,biological_process regulation of cell proliferation	NA	cell division cycle associated 7 [Source:HGNC Symbol%3BAcc:HGNC:14628]
ENSG00000157184	13.50	13.99	12.79	13.92	16.53	14.27	-0.141022067023841	4.9188543858667	0.112649293698376	0.444756896526062	1:53196428-53214197:+	CPT2	14;GO:0004095,molecular_function carnitine O-palmitoyltransferase activity;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0006853,biological_process carnitine shuttle;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019216,biological_process regulation of lipid metabolic process	CPT2; carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]; K08766	carnitine palmitoyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:2330]
ENSG00000012660	100.99	120.37	103.03	95.75	107.81	95.38	0.12787876704659	6.96059914424968	0.11284601824117	0.445391931455529	6:53267397-53349179:-	ELOVL5	28;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0009922,molecular_function fatty acid elongase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0019367,biological_process fatty acid elongation, saturated fatty acid;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030425,cellular_component dendrite;GO:0034625,biological_process fatty acid elongation, monounsaturated fatty acid;GO:0034626,biological_process fatty acid elongation, polyunsaturated fatty acid;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043651,biological_process linoleic acid metabolic process;GO:0045723,biological_process positive regulation of fatty acid biosynthetic process;GO:0097447,cellular_component dendritic tree;GO:0102336,molecular_function 3-oxo-arachidoyl-CoA synthase activity;GO:0102337,molecular_function 3-oxo-cerotoyl-CoA synthase activity;GO:0102338,molecular_function 3-oxo-lignoceronyl-CoA synthase activity	ELOVL5; elongation of very long chain fatty acids protein 5 [EC:2.3.1.199]; K10244	ELOVL fatty acid elongase 5 [Source:HGNC Symbol%3BAcc:HGNC:21308]
ENSG00000163463	99.40	95.37	95.26	86.43	93.48	91.30	0.10953986914626	5.51200559408177	0.112896972200811	0.445451403664549	1:155169407-155173475:-	KRTCAP2	10;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0008150,biological_process biological_process;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042543,biological_process protein N-linked glycosylation via arginine	NA	keratinocyte associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:28942]
ENSG00000120156	0.25	0.20	0.24	0.46	0.18	0.43	-0.626361751386607	0.219941457767864	0.113001090672744	0.445610773023822	9:27109140-27230175:+	TEK	75;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0001725,cellular_component stress fiber;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001935,biological_process endothelial cell proliferation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001958,biological_process endochondral ossification;GO:0002040,biological_process sprouting angiogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0004872,molecular_function receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005902,cellular_component microvillus;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007507,biological_process heart development;GO:0009925,cellular_component basal plasma membrane;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019838,molecular_function growth factor binding;GO:0030054,cellular_component cell junction;GO:0032878,biological_process regulation of establishment or maintenance of cell polarity;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035556,biological_process intracellular signal transduction;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043114,biological_process regulation of vascular permeability;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0043627,biological_process response to estrogen;GO:0045121,cellular_component membrane raft;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046777,biological_process protein autophosphorylation;GO:0048014,biological_process Tie signaling pathway;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050900,biological_process leukocyte migration;GO:0051259,biological_process protein oligomerization;GO:0051591,biological_process response to cAMP;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060216,biological_process definitive hemopoiesis;GO:0060347,biological_process heart trabecula formation;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0072012,biological_process glomerulus vasculature development;GO:1902533,biological_process positive regulation of intracellular signal transduction;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization;GO:2000351,biological_process regulation of endothelial cell apoptotic process;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]; K05121	TEK receptor tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:11724]
ENSG00000115233	99.48	93.10	86.66	106.27	96.15	102.30	-0.114139323641268	6.50384693694231	0.11300916083775	0.445610773023822	2:161308037-161411717:+	PSMD14	55;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010950,biological_process positive regulation of endopeptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0022624,cellular_component proteasome accessory complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031597,cellular_component cytosolic proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061133,molecular_function endopeptidase activator activity;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070628,molecular_function proteasome binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD14, RPN11, POH1; 26S proteasome regulatory subunit N11; K03030	proteasome 26S subunit%2C non-ATPase 14 [Source:HGNC Symbol%3BAcc:HGNC:16889]
ENSG00000155066	2.76	2.35	2.10	3.33	2.25	3.26	-0.28366395121305	2.81667260722197	0.113270864017639	0.44622951611677	2:95274452-95291308:+	PROM2	23;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005902,cellular_component microvillus;GO:0005929,cellular_component cilium;GO:0009986,cellular_component cell surface;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0031346,biological_process positive regulation of cell projection organization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031528,cellular_component microvillus membrane;GO:0042995,cellular_component cell projection;GO:0043087,biological_process regulation of GTPase activity;GO:0044393,cellular_component microspike;GO:0045121,cellular_component membrane raft;GO:0048550,biological_process negative regulation of pinocytosis;GO:0060170,cellular_component ciliary membrane;GO:0070062,cellular_component extracellular exosome;GO:0071914,cellular_component prominosome;GO:2001287,biological_process negative regulation of caveolin-mediated endocytosis	NA	prominin 2 [Source:HGNC Symbol%3BAcc:HGNC:20685]
ENSG00000185245	0.72	0.54	1.24	0.65	0.39	0.68	0.567541977190282	0.627246786536365	0.113286108144148	0.44622951611677	17:4932296-4935030:+	GP1BA	26;GO:0000902,biological_process cell morphogenesis;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007155,biological_process cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007596,biological_process blood coagulation;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0007599,biological_process hemostasis;GO:0009986,cellular_component cell surface;GO:0015057,molecular_function thrombin receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030168,biological_process platelet activation;GO:0030193,biological_process regulation of blood coagulation;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0042730,biological_process fibrinolysis;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0070062,cellular_component extracellular exosome;GO:0070493,biological_process thrombin receptor signaling pathway;GO:0070527,biological_process platelet aggregation	GP1BA, CD42b; platelet glycoprotein Ib alpha chain; K06261	glycoprotein Ib platelet alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:4439]
ENSG00000197956	2600.08	2601.86	2494.53	2732.55	2731.17	2793.97	-0.0898250237178602	9.48882080801077	0.113313419945532	0.44622951611677	1:153534598-153536244:-	S100A6	23;GO:0001726,cellular_component ruffle;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005523,molecular_function tropomyosin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007409,biological_process axonogenesis;GO:0008270,molecular_function zinc ion binding;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0034220,biological_process ion transmembrane transport;GO:0042803,molecular_function protein homodimerization activity;GO:0044548,molecular_function S100 protein binding;GO:0046872,molecular_function metal ion binding;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	S100 calcium binding protein A6 [Source:HGNC Symbol%3BAcc:HGNC:10496]
ENSG00000148484	87.79	100.40	88.75	85.14	94.55	72.18	0.147121387057502	6.19597302935818	0.11331911515817	0.44622951611677	10:16590610-16817528:-	RSU1	7;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070062,cellular_component extracellular exosome	NA	Ras suppressor protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10464]
ENSG00000130024	53.44	52.84	56.13	60.12	55.33	60.78	-0.105624649119624	6.41924546728213	0.113345820052862	0.44622951611677	6:169703904-169725566:-	PHF10	6;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0046872,molecular_function metal ion binding;GO:0071564,cellular_component npBAF complex	NA	PHD finger protein 10 [Source:HGNC Symbol%3BAcc:HGNC:18250]
ENSG00000117525	9.50	5.72	11.06	7.78	5.31	7.79	0.355060299463617	2.84574869463222	0.113424719224111	0.446398554130911	1:94529224-94541800:-	F3	29;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002020,molecular_function protease binding;GO:0002541,biological_process activation of plasma proteins involved in acute inflammatory response;GO:0002543,biological_process activation of blood coagulation via clotting cascade;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0004896,molecular_function cytokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007596,biological_process blood coagulation;GO:0007598,biological_process blood coagulation, extrinsic pathway;GO:0007599,biological_process hemostasis;GO:0009986,cellular_component cell surface;GO:0010641,biological_process positive regulation of platelet-derived growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030335,biological_process positive regulation of cell migration;GO:0031012,cellular_component extracellular matrix;GO:0031233,cellular_component intrinsic component of external side of plasma membrane;GO:0045766,biological_process positive regulation of angiogenesis;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome;GO:1905286,cellular_component serine-type peptidase complex	F3, CD142; coagulation factor III (tissue factor); K03901	coagulation factor III%2C tissue factor [Source:HGNC Symbol%3BAcc:HGNC:3541]
ENSG00000182220	170.12	157.81	166.27	159.23	150.87	155.61	0.0981257023438467	7.60629573554978	0.113527375804059	0.446621427509689	X:40579371-40606848:+	ATP6AP2	22;GO:0002003,biological_process angiotensin maturation;GO:0003824,molecular_function catalytic activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0008152,biological_process metabolic process;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0021903,biological_process rostrocaudal neural tube patterning;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0032914,biological_process positive regulation of transforming growth factor beta1 production;GO:0043005,cellular_component neuron projection;GO:0043312,biological_process neutrophil degranulation;GO:0043408,biological_process regulation of MAPK cascade;GO:0044297,cellular_component cell body;GO:0048069,biological_process eye pigmentation;GO:0060323,biological_process head morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	ATPase H+ transporting accessory protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18305]
ENSG00000141560	30.60	27.38	27.81	26.61	28.65	22.85	0.150862577485414	4.93907508456099	0.113553309048625	0.446621427509689	17:82716682-82730328:+	FN3KRP	5;GO:0005829,cellular_component cytosol;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043687,biological_process post-translational protein modification	NA	fructosamine 3 kinase related protein [Source:HGNC Symbol%3BAcc:HGNC:25700]
ENSG00000179314	10.57	10.81	11.71	12.12	11.44	13.49	-0.151822501264686	4.41187580846009	0.113690522122966	0.446819310811559	17:5772233-6124427:+	WSCD1	3;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	WSC domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29060]
ENSG00000168159	129.73	88.79	136.45	149.85	111.67	156.00	-0.220401840229883	6.51161756752529	0.113729528922671	0.446819310811559	1:228487060-228495766:+	RNF187	14;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination	NA	ring finger protein 187 [Source:HGNC Symbol%3BAcc:HGNC:27146]
ENSG00000137038	145.04	177.19	153.34	140.38	150.33	147.12	0.12579272445466	5.67843431673059	0.113757320914458	0.446819310811559	9:7796489-7888380:-	DMAC1	5;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NA	distal membrane arm assembly complex 1 [Source:HGNC Symbol%3BAcc:HGNC:30536]
ENSG00000162413	9.33	7.11	7.72	6.40	7.91	6.97	0.203690967329511	3.87180630248082	0.113804238153065	0.446819310811559	1:6590723-6614607:-	KLHL21	13;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005827,cellular_component polar microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032465,biological_process regulation of cytokinesis;GO:0035853,biological_process chromosome passenger complex localization to spindle midzone;GO:0043687,biological_process post-translational protein modification;GO:0051301,biological_process cell division	NA	kelch like family member 21 [Source:HGNC Symbol%3BAcc:HGNC:29041]
ENSG00000124733	80.93	87.64	83.81	89.31	94.70	90.21	-0.110571862669696	5.61103259602297	0.113834450392632	0.446819310811559	6:43012093-43013968:-	MEA1	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008584,biological_process male gonad development;GO:0030154,biological_process cell differentiation	NA	male-enhanced antigen 1 [Source:HGNC Symbol%3BAcc:HGNC:6986]
ENSG00000154174	42.44	41.34	41.52	43.84	47.44	44.33	-0.101703948152598	6.31363170450149	0.113839017587508	0.446819310811559	3:100363430-100401398:-	TOMM70	11;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0006626,biological_process protein targeting to mitochondrion;GO:0008320,molecular_function protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0070062,cellular_component extracellular exosome;GO:0071806,biological_process protein transmembrane transport	NA	translocase of outer mitochondrial membrane 70 [Source:HGNC Symbol%3BAcc:HGNC:11985]
ENSG00000198520	3.48	2.97	4.96	2.72	2.82	3.57	0.346141064321385	2.23118247933434	0.113855593337385	0.446819310811559	1:44674691-44725591:+	C1orf228	NA	NA	chromosome 1 open reading frame 228 [Source:HGNC Symbol%3BAcc:HGNC:34345]
ENSG00000132964	8.68	6.04	6.24	5.43	5.56	6.77	0.257730821940012	3.1986724233577	0.113898486828433	0.446846370733674	13:26254103-26405238:+	CDK8	21;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016592,cellular_component mediator complex;GO:0016740,molecular_function transferase activity;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	cyclin dependent kinase 8 [Source:HGNC Symbol%3BAcc:HGNC:1779]
ENSG00000092445	6.09	5.24	6.05	7.26	5.63	7.00	-0.178222800681322	4.12595388247834	0.113960675405138	0.446949088089726	15:41557674-41583586:+	TYRO3	46;GO:0000166,molecular_function nucleotide binding;GO:0001618,molecular_function virus receptor activity;GO:0001779,biological_process natural killer cell differentiation;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0004716,molecular_function receptor signaling protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021885,biological_process forebrain cell migration;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030168,biological_process platelet activation;GO:0032940,biological_process secretion by cell;GO:0034122,biological_process negative regulation of toll-like receptor signaling pathway;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042698,biological_process ovulation cycle;GO:0043277,biological_process apoptotic cell clearance;GO:0043491,biological_process protein kinase B signaling;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0045824,biological_process negative regulation of innate immune response;GO:0046718,biological_process viral entry into host cell;GO:0046777,biological_process protein autophosphorylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051250,biological_process negative regulation of lymphocyte activation;GO:0060068,biological_process vagina development;GO:0070050,biological_process neuron cellular homeostasis;GO:0070527,biological_process platelet aggregation	NA	TYRO3 protein tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:12446]
ENSG00000112335	304.43	326.64	303.75	295.66	289.46	295.04	0.0976219006908007	7.42393754442537	0.114100446331032	0.447193771363856	6:108211221-108261260:-	SNX3	36;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0009617,biological_process response to bacterium;GO:0010008,cellular_component endosome membrane;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0010324,biological_process membrane invagination;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015031,biological_process protein transport;GO:0016055,biological_process Wnt signaling pathway;GO:0016579,biological_process protein deubiquitination;GO:0019898,cellular_component extrinsic component of membrane;GO:0019903,molecular_function protein phosphatase binding;GO:0022615,biological_process protein to membrane docking;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030904,cellular_component retromer complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0032009,cellular_component early phagosome;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0045335,cellular_component phagocytic vesicle;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0050765,biological_process negative regulation of phagocytosis;GO:0051224,biological_process negative regulation of protein transport;GO:0070062,cellular_component extracellular exosome;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0070676,biological_process intralumenal vesicle formation;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:2000642,biological_process negative regulation of early endosome to late endosome transport	NA	sorting nexin 3 [Source:HGNC Symbol%3BAcc:HGNC:11174]
ENSG00000149115	44.67	43.31	44.06	41.13	42.64	41.01	0.0935343481839436	7.79686421724236	0.114118490196671	0.447193771363856	11:57299637-57324952:-	TNKS1BP1	21;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005720,cellular_component nuclear heterochromatin;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005913,cellular_component cell-cell adherens junction;GO:0006302,biological_process double-strand break repair;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007004,biological_process telomere maintenance via telomerase;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030014,cellular_component CCR4-NOT complex;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0044877,molecular_function macromolecular complex binding;GO:0045296,molecular_function cadherin binding;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071532,molecular_function ankyrin repeat binding	NA	tankyrase 1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19081]
ENSG00000189050	17.76	17.20	19.27	18.17	21.20	21.05	-0.14165860506224	4.7072896400112	0.114144420574211	0.447193771363856	17:59952239-59964761:-	RNFT1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	ring finger protein%2C transmembrane 1 [Source:HGNC Symbol%3BAcc:HGNC:30206]
ENSG00000126870	16.92	16.38	16.69	16.22	14.42	16.03	0.110839943153719	5.69211744761468	0.114167168408286	0.447193771363856	7:158856577-158956747:+	WDR60	20;GO:0000242,cellular_component pericentriolar material;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005813,cellular_component centrosome;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0030030,biological_process cell projection organization;GO:0031021,cellular_component interphase microtubule organizing center;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045504,molecular_function dynein heavy chain binding;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base	NA	WD repeat domain 60 [Source:HGNC Symbol%3BAcc:HGNC:21862]
ENSG00000140688	56.54	49.62	55.67	50.93	49.16	51.39	0.110312949437477	6.20102355447623	0.11425400075084	0.447262978454129	16:31489470-31509309:-	C16orf58	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 16 open reading frame 58 [Source:HGNC Symbol%3BAcc:HGNC:25848]
ENSG00000125166	61.98	68.38	64.19	70.00	75.61	66.50	-0.114522707885573	6.45278401196816	0.114256900401035	0.447262978454129	16:58707130-58734357:-	GOT2	44;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004069,molecular_function L-aspartate:2-oxoglutarate aminotransferase activity;GO:0005543,molecular_function phospholipid binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0006094,biological_process gluconeogenesis;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006531,biological_process aspartate metabolic process;GO:0006532,biological_process aspartate biosynthetic process;GO:0006533,biological_process aspartate catabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0009986,cellular_component cell surface;GO:0015908,biological_process fatty acid transport;GO:0016020,cellular_component membrane;GO:0016212,molecular_function kynurenine-oxoglutarate transaminase activity;GO:0016597,molecular_function amino acid binding;GO:0016740,molecular_function transferase activity;GO:0019470,biological_process 4-hydroxyproline catabolic process;GO:0019550,biological_process glutamate catabolic process to aspartate;GO:0019551,biological_process glutamate catabolic process to 2-oxoglutarate;GO:0019899,molecular_function enzyme binding;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0031406,molecular_function carboxylic acid binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043204,cellular_component perikaryon;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043648,biological_process dicarboxylic acid metabolic process;GO:0045471,biological_process response to ethanol;GO:0046487,biological_process glyoxylate metabolic process;GO:0047578,molecular_function 4-hydroxyglutamate transaminase activity;GO:0070062,cellular_component extracellular exosome;GO:0080130,molecular_function L-phenylalanine:2-oxoglutarate aminotransferase activity;GO:0097052,biological_process L-kynurenine metabolic process	GOT2; aspartate aminotransferase, mitochondrial [EC:2.6.1.1]; K14455	glutamic-oxaloacetic transaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:4433]
ENSG00000167543	24.35	22.04	24.37	21.20	19.68	23.92	0.140837690252041	4.90167584473149	0.114347250367996	0.447475541871984	17:29566051-29573157:+	TP53I13	4;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	tumor protein p53 inducible protein 13 [Source:HGNC Symbol%3BAcc:HGNC:25102]
ENSG00000145723	5.77	3.97	5.97	6.79	6.54	5.57	-0.236529158870084	3.21138969109458	0.114390857656645	0.447505110649839	5:103085999-103120151:-	GIN1	2;GO:0003676,molecular_function nucleic acid binding;GO:0015074,biological_process DNA integration	NA	gypsy retrotransposon integrase 1 [Source:HGNC Symbol%3BAcc:HGNC:25959]
ENSG00000196233	1.92	1.66	2.39	2.07	2.39	2.55	-0.214549406820009	3.63717445551652	0.114461359118599	0.447542045844473	10:96832281-96995959:+	LCOR	6;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	ligand dependent nuclear receptor corepressor [Source:HGNC Symbol%3BAcc:HGNC:29503]
ENSG00000119787	27.99	27.74	25.40	29.00	29.89	29.05	-0.105466515531284	5.96172486705459	0.114472407601402	0.447542045844473	2:38294879-38377285:-	ATL2	13;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0051260,biological_process protein homooligomerization	NA	atlastin GTPase 2 [Source:HGNC Symbol%3BAcc:HGNC:24047]
ENSG00000122863	9.63	9.84	10.96	9.48	8.81	9.05	0.167617907347874	3.80645349306012	0.114698529899245	0.448131010613102	10:71964364-72013564:+	CHST3	11;GO:0000139,cellular_component Golgi membrane;GO:0001517,molecular_function N-acetylglucosamine 6-O-sulfotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006790,biological_process sulfur compound metabolic process;GO:0008146,molecular_function sulfotransferase activity;GO:0008459,molecular_function chondroitin 6-sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030206,biological_process chondroitin sulfate biosynthetic process	CHST3; chondroitin 6-sulfotransferase 3 [EC:2.8.2.17]; K01020	carbohydrate sulfotransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:1971]
ENSG00000198843	107.95	114.65	110.15	94.72	113.38	100.64	0.118755616208364	5.99673984819027	0.114703901703114	0.448131010613102	3:150602874-150630445:+	SELENOT	17;GO:0001514,biological_process selenocysteine incorporation;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008430,molecular_function selenium binding;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031016,biological_process pancreas development;GO:0035773,biological_process insulin secretion involved in cellular response to glucose stimulus;GO:0042593,biological_process glucose homeostasis;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0060124,biological_process positive regulation of growth hormone secretion;GO:0098869,biological_process cellular oxidant detoxification	NA	selenoprotein T [Source:HGNC Symbol%3BAcc:HGNC:18136]
ENSG00000197467	2.39	0.85	2.69	1.60	0.91	1.66	0.533001521431802	2.00599498984308	0.114750962146615	0.448131010613102	10:69801930-69964275:+	COL13A1	23;GO:0001503,biological_process ossification;GO:0001763,biological_process morphogenesis of a branching structure;GO:0001958,biological_process endochondral ossification;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005581,cellular_component collagen trimer;GO:0005600,cellular_component collagen type XIII trimer;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007275,biological_process multicellular organism development;GO:0008201,molecular_function heparin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	COL13A; collagen, type XIII, alpha; K16617	collagen type XIII alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2190]
ENSG00000128585	14.99	15.78	16.12	14.57	13.96	14.99	0.117369727971807	5.06063428888472	0.11476746014171	0.448131010613102	7:131110095-131496636:+	MKLN1	9;GO:0001726,cellular_component ruffle;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005938,cellular_component cell cortex;GO:0007160,biological_process cell-matrix adhesion;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0042995,cellular_component cell projection	NA	muskelin 1 [Source:HGNC Symbol%3BAcc:HGNC:7109]
ENSG00000156052	31.05	30.21	30.85	33.65	33.95	32.79	-0.110581815691794	5.1828215436744	0.114825558820382	0.448216874728742	9:77716086-78031458:-	GNAQ	47;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001508,biological_process action potential;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007202,biological_process activation of phospholipase C activity;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007215,biological_process glutamate receptor signaling pathway;GO:0007507,biological_process heart development;GO:0007596,biological_process blood coagulation;GO:0007603,biological_process phototransduction, visible light;GO:0009649,biological_process entrainment of circadian clock;GO:0009791,biological_process post-embryonic development;GO:0016020,cellular_component membrane;GO:0016322,biological_process neuron remodeling;GO:0019001,molecular_function guanyl nucleotide binding;GO:0021884,biological_process forebrain neuron development;GO:0030168,biological_process platelet activation;GO:0030425,cellular_component dendrite;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031826,molecular_function type 2A serotonin receptor binding;GO:0031965,cellular_component nuclear membrane;GO:0035412,biological_process regulation of catenin import into nucleus;GO:0042711,biological_process maternal behavior;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044297,cellular_component cell body;GO:0045634,biological_process regulation of melanocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0048066,biological_process developmental pigmentation;GO:0050821,biological_process protein stabilization;GO:0060158,biological_process phospholipase C-activating dopamine receptor signaling pathway;GO:0070062,cellular_component extracellular exosome	GNAQ; guanine nucleotide-binding protein G(q) subunit alpha; K04634	G protein subunit alpha q [Source:HGNC Symbol%3BAcc:HGNC:4390]
ENSG00000143258	18.96	22.78	20.97	19.30	19.37	18.96	0.127556713186902	5.09088485280021	0.114990731910917	0.448720514055395	1:161159449-161165723:+	USP21	24;GO:0003713,molecular_function transcription coactivator activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019784,molecular_function NEDD8-specific protease activity;GO:0031175,biological_process neuron projection development;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	ubiquitin specific peptidase 21 [Source:HGNC Symbol%3BAcc:HGNC:12620]
ENSG00000173273	6.34	6.18	6.85	6.08	6.03	5.76	0.132252050493911	4.7096156749515	0.115154480024886	0.448964319098052	8:9555913-9782346:+	TNKS	50;GO:0000139,cellular_component Golgi membrane;GO:0000209,biological_process protein polyubiquitination;GO:0000242,cellular_component pericentriolar material;GO:0000775,cellular_component chromosome, centromeric region;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000922,cellular_component spindle pole;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006471,biological_process protein ADP-ribosylation;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0031965,cellular_component nuclear membrane;GO:0032210,biological_process regulation of telomere maintenance via telomerase;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0042393,molecular_function histone binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051028,biological_process mRNA transport;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0051973,biological_process positive regulation of telomerase activity;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0070212,biological_process protein poly-ADP-ribosylation;GO:0070213,biological_process protein auto-ADP-ribosylation;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097431,cellular_component mitotic spindle pole;GO:1904355,biological_process positive regulation of telomere capping;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1904743,biological_process negative regulation of telomeric DNA binding;GO:1904908,biological_process negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	NA	tankyrase [Source:HGNC Symbol%3BAcc:HGNC:11941]
ENSG00000143498	7.90	7.36	6.81	9.04	7.58	8.85	-0.195273730176823	3.44398365015582	0.115154507599869	0.448964319098052	1:222557901-222589933:-	TAF1A	15;GO:0000120,cellular_component RNA polymerase I transcription factor complex;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006360,biological_process transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0015630,cellular_component microtubule cytoskeleton;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045815,biological_process positive regulation of gene expression, epigenetic	NA	TATA-box binding protein associated factor%2C RNA polymerase I subunit A [Source:HGNC Symbol%3BAcc:HGNC:11532]
ENSG00000248098	5.02	5.26	7.01	5.55	5.16	3.52	0.297490450791268	3.11036784369478	0.115178932425209	0.448964319098052	19:41397459-41425005:+	BCKDHA	14;GO:0003826,molecular_function alpha-ketoacid dehydrogenase activity;GO:0003863,molecular_function 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005947,cellular_component mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016624,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;GO:0016831,molecular_function carboxy-lyase activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	BCKDHA, bkdA1; 2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]; K00166	branched chain keto acid dehydrogenase E1%2C alpha polypeptide [Source:HGNC Symbol%3BAcc:HGNC:986]
ENSG00000160299	5.95	6.55	5.57	5.49	5.49	5.80	0.113945673090575	5.86427566514483	0.115197885791291	0.448964319098052	21:46324121-46445769:+	PCNT	18;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007052,biological_process mitotic spindle organization;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0034451,cellular_component centriolar satellite;GO:0060271,biological_process cilium morphogenesis;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	pericentrin [Source:HGNC Symbol%3BAcc:HGNC:16068]
ENSG00000151338	7.61	7.56	6.64	5.87	7.01	6.25	0.199384638124721	3.30425151129553	0.115278016660908	0.449135599752623	14:37197912-37552361:+	MIPOL1	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0042802,molecular_function identical protein binding	NA	mirror-image polydactyly 1 [Source:HGNC Symbol%3BAcc:HGNC:21460]
ENSG00000119977	31.02	33.62	29.83	28.55	30.51	29.13	0.107960838694439	5.93150339573834	0.115382666058732	0.449402269779428	10:95663395-95694143:-	TCTN3	11;GO:0005634,cellular_component nucleus;GO:0006915,biological_process apoptotic process;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0043065,biological_process positive regulation of apoptotic process;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	tectonic family member 3 [Source:HGNC Symbol%3BAcc:HGNC:24519]
ENSG00000052841	29.81	26.74	31.66	31.12	31.59	33.60	-0.112948802471993	6.84643103495518	0.115549733160777	0.44991180606171	11:43358931-43494933:+	TTC17	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0030041,biological_process actin filament polymerization;GO:0044782,biological_process cilium organization	NA	tetratricopeptide repeat domain 17 [Source:HGNC Symbol%3BAcc:HGNC:25596]
ENSG00000158773	30.76	27.95	31.26	33.09	33.44	32.51	-0.121190810199872	4.88364787022515	0.115586177606596	0.449912581571238	1:161039250-161045977:-	USF1	37;GO:0000430,biological_process regulation of transcription from RNA polymerase II promoter by glucose;GO:0000432,biological_process positive regulation of transcription from RNA polymerase II promoter by glucose;GO:0000790,cellular_component nuclear chromatin;GO:0001666,biological_process response to hypoxia;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006006,biological_process glucose metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0009411,biological_process response to UV;GO:0016589,cellular_component NURF complex;GO:0019086,biological_process late viral transcription;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045990,biological_process carbon catabolite regulation of transcription;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051918,biological_process negative regulation of fibrinolysis;GO:0055088,biological_process lipid homeostasis	NA	upstream transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:12593]
ENSG00000131748	28.18	27.62	27.77	25.61	25.85	26.80	0.106551839047469	5.40431107561405	0.115647879099508	0.450011637386268	17:39637064-39663484:+	STARD3	26;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0006701,biological_process progesterone biosynthetic process;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0006869,biological_process lipid transport;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008289,molecular_function lipid binding;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017127,molecular_function cholesterol transporter activity;GO:0030301,biological_process cholesterol transport;GO:0031902,cellular_component late endosome membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0044232,cellular_component organelle membrane contact site;GO:0099044,biological_process vesicle tethering to endoplasmic reticulum	NA	StAR related lipid transfer domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:17579]
ENSG00000141294	0.94	1.45	0.97	1.77	1.51	1.40	-0.494364482191835	0.640221246771864	0.115858496327657	0.450689913793546	17:47831626-47837713:+	LRRC46	2;GO:0031647,biological_process regulation of protein stability;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	leucine rich repeat containing 46 [Source:HGNC Symbol%3BAcc:HGNC:25047]
ENSG00000162929	9.15	8.85	8.71	9.73	9.32	10.64	-0.141611288196103	4.41379606682712	0.115901490450239	0.45070313869675	2:61065870-61138034:+	KIAA1841	1;GO:0003677,molecular_function DNA binding	NA	KIAA1841 [Source:HGNC Symbol%3BAcc:HGNC:29387]
ENSG00000185963	9.87	8.86	9.89	10.88	10.19	10.60	-0.128431825985546	4.70189065230941	0.115934513965901	0.45070313869675	9:92711362-92764812:-	BICD2	24;GO:0000042,biological_process protein targeting to Golgi;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005642,cellular_component annulate lamellae;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0015031,biological_process protein transport;GO:0017137,molecular_function Rab GTPase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034452,molecular_function dynactin binding;GO:0051028,biological_process mRNA transport;GO:0051642,biological_process centrosome localization;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0070840,molecular_function dynein complex binding;GO:0072385,biological_process minus-end-directed organelle transport along microtubule;GO:0072393,biological_process microtubule anchoring at microtubule organizing center	NA	BICD cargo adaptor 2 [Source:HGNC Symbol%3BAcc:HGNC:17208]
ENSG00000173486	89.36	93.77	102.80	87.35	90.44	87.48	0.120429544146538	5.29627277681925	0.116055872533445	0.451033671182733	11:64241002-64244132:+	FKBP2	10;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005528,molecular_function FK506 binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome	NA	FK506 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:3718]
ENSG00000162852	4.84	4.76	5.92	7.19	5.03	6.11	-0.223562292711166	3.64916547425806	0.116122805025231	0.451049092555855	1:246566443-246668584:+	CNST	14;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019902,molecular_function phosphatase binding;GO:0030133,cellular_component transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042998,biological_process positive regulation of Golgi to plasma membrane protein transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0071253,molecular_function connexin binding	NA	consortin%2C connexin sorting protein [Source:HGNC Symbol%3BAcc:HGNC:26486]
ENSG00000265808	102.33	97.32	87.09	87.81	93.02	85.87	0.116179210311727	6.14226143414751	0.116157395386811	0.451049092555855	1:120150897-120176515:-	SEC22B	28;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030133,cellular_component transport vesicle;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042470,cellular_component melanosome;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0048208,biological_process COPII vesicle coating;GO:0048280,biological_process vesicle fusion with Golgi apparatus;GO:1902902,biological_process negative regulation of autophagosome assembly;GO:1990668,biological_process vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	NA	SEC22 homolog B%2C vesicle trafficking protein (gene/pseudogene) [Source:HGNC Symbol%3BAcc:HGNC:10700]
ENSG00000130653	1.81	1.25	2.25	1.65	1.16	1.48	0.332038438495449	2.7687969017556	0.116168851115852	0.451049092555855	9:137459952-137550534:-	PNPLA7	17;GO:0004622,molecular_function lysophospholipase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0006629,biological_process lipid metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0031090,cellular_component organelle membrane;GO:0031965,cellular_component nuclear membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032502,biological_process developmental process;GO:0043231,cellular_component intracellular membrane-bounded organelle	NTE, NRE; lysophospholipid hydrolase [EC:3.1.1.5]; K14676	patatin like phospholipase domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:24768]
ENSG00000132424	106.10	102.19	107.26	96.91	100.09	101.51	0.0923084879190829	8.03085265521345	0.116414493007766	0.4517263452816	6:99398050-99425331:-	PNISR	4;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0016607,cellular_component nuclear speck	NA	PNN interacting serine and arginine rich protein [Source:HGNC Symbol%3BAcc:HGNC:21222]
ENSG00000260428	7.61	4.75	8.30	5.59	5.03	5.95	0.352327122711762	1.97611192981571	0.11641606207652	0.4517263452816	8:144266559-144268481:+	SCX	45;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001707,biological_process mesoderm formation;GO:0001894,biological_process tissue homeostasis;GO:0001958,biological_process endochondral ossification;GO:0002062,biological_process chondrocyte differentiation;GO:0003179,biological_process heart valve morphogenesis;GO:0003188,biological_process heart valve formation;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0030199,biological_process collagen fibril organization;GO:0030509,biological_process BMP signaling pathway;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0035989,biological_process tendon development;GO:0035990,biological_process tendon cell differentiation;GO:0035992,biological_process tendon formation;GO:0035993,biological_process deltoid tuberosity development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048706,biological_process embryonic skeletal system development;GO:0060008,biological_process Sertoli cell differentiation;GO:0060325,biological_process face morphogenesis;GO:0061035,biological_process regulation of cartilage development;GO:0061036,biological_process positive regulation of cartilage development;GO:0061056,biological_process sclerotome development;GO:0070888,molecular_function E-box binding;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071773,biological_process cellular response to BMP stimulus;GO:2000543,biological_process positive regulation of gastrulation	NA	scleraxis bHLH transcription factor [Source:HGNC Symbol%3BAcc:HGNC:32322]
ENSG00000103035	90.00	98.91	93.00	104.66	98.71	102.06	-0.105757032105473	6.65560840374208	0.1164892158912	0.45186894901796	16:74296774-74306288:+	PSMD7	37;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD7, RPN8; 26S proteasome regulatory subunit N8; K03038	proteasome 26S subunit%2C non-ATPase 7 [Source:HGNC Symbol%3BAcc:HGNC:9565]
ENSG00000278662	0.81	0.85	0.61	0.53	0.34	0.67	0.550598389834153	0.189423141653696	0.116531563594318	0.451892002154411	15:82339997-82349475:-	GOLGA6L10	1;GO:0005794,cellular_component Golgi apparatus	NA	golgin A6 family-like 10 [Source:HGNC Symbol%3BAcc:HGNC:37228]
ENSG00000106701	1.77	2.35	1.89	1.59	1.33	1.84	0.324823749698489	1.77021785489247	0.116687570879481	0.452355658128358	9:105447795-105552433:+	FSD1L	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	fibronectin type III and SPRY domain containing 1 like [Source:HGNC Symbol%3BAcc:HGNC:13753]
ENSG00000004799	2.81	3.33	3.58	2.00	2.89	2.91	0.321450832884871	1.90265020328079	0.116736169580201	0.452402770215122	7:95583498-95596491:-	PDK4	27;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004740,molecular_function pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006468,biological_process protein phosphorylation;GO:0006885,biological_process regulation of pH;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009267,biological_process cellular response to starvation;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010565,biological_process regulation of cellular ketone metabolic process;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0042593,biological_process glucose homeostasis;GO:0042594,biological_process response to starvation;GO:0045124,biological_process regulation of bone resorption;GO:0046320,biological_process regulation of fatty acid oxidation;GO:0071398,biological_process cellular response to fatty acid;GO:0072593,biological_process reactive oxygen species metabolic process;GO:2000811,biological_process negative regulation of anoikis	NA	pyruvate dehydrogenase kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:8812]
ENSG00000095303	3.88	3.40	4.78	3.33	2.19	4.16	0.332298704806617	2.82982077466484	0.116804029895677	0.452524476621423	9:122370529-122395703:+	PTGS1	29;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0001750,cellular_component photoreceptor outer segment;GO:0004601,molecular_function peroxidase activity;GO:0004666,molecular_function prostaglandin-endoperoxide synthase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0006954,biological_process inflammatory response;GO:0006979,biological_process response to oxidative stress;GO:0008217,biological_process regulation of blood pressure;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019371,biological_process cyclooxygenase pathway;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0042127,biological_process regulation of cell proliferation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	PTGS1, COX1; prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]; K00509	prostaglandin-endoperoxide synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:9604]
ENSG00000135624	171.01	187.29	155.24	189.23	190.21	181.11	-0.115467307470469	8.19887213575332	0.116878875555061	0.452544113707716	2:73233419-73253021:+	CCT7	24;GO:0000166,molecular_function nucleotide binding;GO:0002199,cellular_component zona pellucida receptor complex;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0042802,molecular_function identical protein binding;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044297,cellular_component cell body;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:1901998,biological_process toxin transport;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	chaperonin containing TCP1 subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:1622]
ENSG00000164978	36.03	37.49	34.21	35.65	31.99	28.70	0.1713582253727	3.91790033495151	0.116918303117336	0.452544113707716	9:34329505-34343713:+	NUDT2	12;GO:0000166,molecular_function nucleotide binding;GO:0004081,molecular_function bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006915,biological_process apoptotic process;GO:0008796,molecular_function bis(5'-nucleosyl)-tetraphosphatase activity;GO:0008803,molecular_function bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity;GO:0016787,molecular_function hydrolase activity;GO:0034599,biological_process cellular response to oxidative stress	NUDT2; bis(5'-nucleosidyl)-tetraphosphatase [EC:3.6.1.17]; K01518	nudix hydrolase 2 [Source:HGNC Symbol%3BAcc:HGNC:8049]
ENSG00000136193	74.67	70.45	72.22	78.18	75.40	81.42	-0.100279365205172	6.70564621364908	0.116940336533479	0.452544113707716	7:29920102-29990289:-	SCRN1	8;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0006887,biological_process exocytosis;GO:0016805,molecular_function dipeptidase activity;GO:0031965,cellular_component nuclear membrane	NA	secernin 1 [Source:HGNC Symbol%3BAcc:HGNC:22192]
ENSG00000136159	7.90	9.71	12.87	13.85	12.18	11.72	-0.295155695351227	2.5265094635845	0.116954927638311	0.452544113707716	13:48037566-48047222:+	NUDT15	18;GO:0000278,biological_process mitotic cell cycle;GO:0004551,molecular_function nucleotide diphosphatase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006195,biological_process purine nucleotide catabolic process;GO:0006203,biological_process dGTP catabolic process;GO:0008413,molecular_function 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0035529,molecular_function NADH pyrophosphatase activity;GO:0035539,molecular_function 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0042262,biological_process DNA protection;GO:0042738,biological_process exogenous drug catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047429,molecular_function nucleoside-triphosphate diphosphatase activity;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:1901292,biological_process nucleoside phosphate catabolic process	NA	nudix hydrolase 15 [Source:HGNC Symbol%3BAcc:HGNC:23063]
ENSG00000198814	3.04	3.05	2.91	2.62	2.61	2.42	0.245100068792587	2.48940712491101	0.117085559093633	0.452894705476139	X:30653358-30731456:+	GK	21;GO:0000166,molecular_function nucleotide binding;GO:0004370,molecular_function glycerol kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006071,biological_process glycerol metabolic process;GO:0006072,biological_process glycerol-3-phosphate metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019432,biological_process triglyceride biosynthetic process;GO:0019563,biological_process glycerol catabolic process;GO:0046167,biological_process glycerol-3-phosphate biosynthetic process;GO:0070062,cellular_component extracellular exosome	glpK, GK; glycerol kinase [EC:2.7.1.30]; K00864	glycerol kinase [Source:HGNC Symbol%3BAcc:HGNC:4289]
ENSG00000130811	100.25	102.01	102.93	111.26	103.47	115.58	-0.102746124399118	6.92127038732408	0.117118505162201	0.452894705476139	19:10115016-10119918:-	EIF3G	11;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0075525,biological_process viral translational termination-reinitiation	EIF3G; translation initiation factor 3 subunit G; K03248	eukaryotic translation initiation factor 3 subunit G [Source:HGNC Symbol%3BAcc:HGNC:3274]
ENSG00000088970	15.91	14.42	15.23	13.98	13.55	14.77	0.121707425072302	5.03980371443233	0.117257444783071	0.45329076988236	20:21125982-21246622:+	KIZ	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007051,biological_process spindle organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0042995,cellular_component cell projection	NA	kizuna centrosomal protein [Source:HGNC Symbol%3BAcc:HGNC:15865]
ENSG00000124615	6.85	6.20	6.43	6.80	7.72	7.53	-0.162392453894267	3.86888066178592	0.117329695922906	0.453365196810767	6:39899577-39934551:-	MOCS1	14;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006777,biological_process Mo-molybdopterin cofactor biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0019008,cellular_component molybdopterin synthase complex;GO:0032324,biological_process molybdopterin cofactor biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0061798,molecular_function GTP 3',8'-cyclase activity;GO:0061799,molecular_function cyclic pyranopterin monophosphate synthase activity	moaA, CNX2; GTP 3',8-cyclase [EC:4.1.99.22]; K03639	molybdenum cofactor synthesis 1 [Source:HGNC Symbol%3BAcc:HGNC:7190]
ENSG00000196312	20.30	18.57	17.73	16.98	16.43	16.51	0.195643372513596	3.15705902156113	0.117352269230941	0.453365196810767	9:96897916-97013708:-	MFSD14C	5;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	major facilitator superfamily domain containing 14C [Source:HGNC Symbol%3BAcc:HGNC:23672]
ENSG00000198034	2377.74	2392.29	2372.03	2335.36	2151.37	2272.19	0.0913100635610453	10.8372858233503	0.117386267828068	0.453365196810767	X:72255678-72277300:-	RPS4X	27;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005844,cellular_component polysome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0045727,biological_process positive regulation of translation;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein S4%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:10424]
ENSG00000119321	16.13	15.81	15.72	15.23	14.79	14.85	0.0993159182027737	5.86388911757829	0.117453555984049	0.45348397836081	9:113161005-113221361:-	FKBP15	16;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005884,cellular_component actin filament;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0042995,cellular_component cell projection	NA	FK506 binding protein 15 [Source:HGNC Symbol%3BAcc:HGNC:23397]
ENSG00000198892	21.03	20.70	24.78	20.14	20.15	18.92	0.184854311334048	3.64883995906225	0.117553950278844	0.453730467913958	1:201888679-201892306:+	SHISA4	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	shisa family member 4 [Source:HGNC Symbol%3BAcc:HGNC:27139]
ENSG00000165355	4.24	4.59	2.87	3.06	3.01	3.51	0.289709341130571	2.58814935223905	0.11764353551703	0.453935096789832	14:39397668-39432500:-	FBXO33	2;GO:0005515,molecular_function protein binding;GO:0016567,biological_process protein ubiquitination	NA	F-box protein 33 [Source:HGNC Symbol%3BAcc:HGNC:19833]
ENSG00000135378	0.94	1.55	0.98	1.44	2.24	1.66	-0.640984833649484	0.189399967311353	0.117800526804021	0.453992894854559	11:32829942-32858123:+	PRRG4	6;GO:0003674,molecular_function molecular_function;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	proline rich and Gla domain 4 [Source:HGNC Symbol%3BAcc:HGNC:30799]
ENSG00000261609	1.38	0.69	1.11	1.46	1.27	1.57	-0.387368896835296	1.28006209318603	0.117821803448863	0.453992894854559	16:81314951-81390884:+	GAN	10;GO:0003674,molecular_function molecular_function;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification	NA	gigaxonin [Source:HGNC Symbol%3BAcc:HGNC:4137]
ENSG00000136279	52.28	52.94	54.27	46.32	52.76	50.29	0.106483176033539	6.16456418545218	0.117846145160582	0.453992894854559	7:44044639-44069456:+	DBNL	45;GO:0000139,cellular_component Golgi membrane;GO:0001726,cellular_component ruffle;GO:0002102,cellular_component podosome;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007257,biological_process activation of JUN kinase activity;GO:0007416,biological_process synapse assembly;GO:0008022,molecular_function protein C-terminus binding;GO:0008047,molecular_function enzyme activator activity;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016601,biological_process Rac protein signal transduction;GO:0019904,molecular_function protein domain specific binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034774,cellular_component secretory granule lumen;GO:0042995,cellular_component cell projection;GO:0043312,biological_process neutrophil degranulation;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome;GO:0071800,biological_process podosome assembly;GO:0097178,biological_process ruffle assembly;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	drebrin like [Source:HGNC Symbol%3BAcc:HGNC:2696]
ENSG00000141127	20.74	20.04	21.78	24.05	21.37	23.53	-0.126485192399387	4.89205972028469	0.117900548465321	0.453992894854559	17:18840084-18931287:+	PRPSAP2	11;GO:0000287,molecular_function magnesium ion binding;GO:0002189,cellular_component ribose phosphate diphosphokinase complex;GO:0004749,molecular_function ribose phosphate diphosphokinase activity;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0009116,biological_process nucleoside metabolic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0060348,biological_process bone development	NA	phosphoribosyl pyrophosphate synthetase associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9467]
ENSG00000163481	14.87	11.59	12.61	14.74	14.87	14.55	-0.155231711829236	4.27357927665032	0.117905460363805	0.453992894854559	2:218663863-218672411:-	RNF25	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0051059,molecular_function NF-kappaB binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 25 [Source:HGNC Symbol%3BAcc:HGNC:14662]
ENSG00000223547	3.00	2.01	2.73	2.06	2.16	2.22	0.295835406992287	2.29553144356265	0.117910973978411	0.453992894854559	19:12064698-12081565:+	ZNF844	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 844 [Source:HGNC Symbol%3BAcc:HGNC:25932]
ENSG00000110047	33.64	37.49	33.49	31.70	34.65	30.75	0.116456974791864	5.79088944428846	0.117928847874596	0.453992894854559	11:64851641-64888296:-	EHD1	44;GO:0000166,molecular_function nucleotide binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005811,cellular_component lipid particle;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007596,biological_process blood coagulation;GO:0010008,cellular_component endosome membrane;GO:0010886,biological_process positive regulation of cholesterol storage;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0017137,molecular_function Rab GTPase binding;GO:0020018,cellular_component ciliary pocket membrane;GO:0030030,biological_process cell projection organization;GO:0030139,cellular_component endocytic vesicle;GO:0031095,cellular_component platelet dense tubular network membrane;GO:0031175,biological_process neuron projection development;GO:0031901,cellular_component early endosome membrane;GO:0032456,biological_process endocytic recycling;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0042632,biological_process cholesterol homeostasis;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051260,biological_process protein homooligomerization;GO:0055038,cellular_component recycling endosome membrane;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0061512,biological_process protein localization to cilium;GO:0070062,cellular_component extracellular exosome;GO:1901741,biological_process positive regulation of myoblast fusion;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2001137,biological_process positive regulation of endocytic recycling	EHD1; EH domain-containing protein 1; K12483	EH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:3242]
ENSG00000102780	1.13	1.58	0.99	1.69	1.56	1.33	-0.314772775379718	2.42380054942875	0.117951106574233	0.453992894854559	13:42040035-42256578:+	DGKH	19;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030168,biological_process platelet activation;GO:0035556,biological_process intracellular signal transduction;GO:0046473,biological_process phosphatidic acid metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051259,biological_process protein oligomerization	dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]; K00901	diacylglycerol kinase eta [Source:HGNC Symbol%3BAcc:HGNC:2854]
ENSG00000148175	23.30	20.15	24.62	20.03	19.52	22.08	0.161416637101386	4.26867093931058	0.118128757755488	0.454535731561956	9:121338987-121370304:-	STOM	31;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0042470,cellular_component melanosome;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0044829,biological_process positive regulation by host of viral genome replication;GO:0045121,cellular_component membrane raft;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048524,biological_process positive regulation of viral process;GO:0051260,biological_process protein homooligomerization;GO:0070062,cellular_component extracellular exosome;GO:0070063,molecular_function RNA polymerase binding;GO:0070821,cellular_component tertiary granule membrane;GO:0072562,cellular_component blood microparticle;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1901585,biological_process regulation of acid-sensing ion channel activity	NA	stomatin [Source:HGNC Symbol%3BAcc:HGNC:3383]
ENSG00000165119	518.04	544.73	530.53	558.10	592.12	562.40	-0.0925199076512717	9.61995602396304	0.118208088746641	0.454694425536307	9:83968082-83980616:-	HNRNPK	43;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002102,cellular_component podosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0007165,biological_process signal transduction;GO:0008380,biological_process RNA splicing;GO:0010988,biological_process regulation of low-density lipoprotein particle clearance;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016070,biological_process RNA metabolic process;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045296,molecular_function cadherin binding;GO:0045716,biological_process positive regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0072369,biological_process regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter;GO:1902165,biological_process regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	HNRNPK; heterogeneous nuclear ribonucleoprotein K; K12886	heterogeneous nuclear ribonucleoprotein K [Source:HGNC Symbol%3BAcc:HGNC:5044]
ENSG00000172159	2.46	1.78	2.13	3.08	2.94	2.03	-0.309564874985913	2.34699354753458	0.11824326155089	0.454694425536307	9:83242989-83538546:-	FRMD3	6;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005856,cellular_component cytoskeleton;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031032,biological_process actomyosin structure organization	NA	FERM domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:24125]
ENSG00000114374	6.82	6.52	6.94	6.90	7.67	7.49	-0.107019512900846	5.76311775162545	0.118350018990838	0.454964009208198	Y:12701230-12860839:+	USP9Y	14;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016477,biological_process cell migration;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030509,biological_process BMP signaling pathway;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0070410,molecular_function co-SMAD binding	NA	ubiquitin specific peptidase 9%2C Y-linked [Source:HGNC Symbol%3BAcc:HGNC:12633]
ENSG00000091106	0.46	0.59	0.58	0.80	0.72	0.66	-0.42233887217559	1.07235890322824	0.118457245510294	0.455235228643738	2:32224452-32265854:-	NLRC4	31;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002218,biological_process activation of innate immune response;GO:0002376,biological_process immune system process;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954,biological_process inflammatory response;GO:0009966,biological_process regulation of signal transduction;GO:0016045,biological_process detection of bacterium;GO:0016567,biological_process protein ubiquitination;GO:0042742,biological_process defense response to bacterium;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043281,biological_process regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045087,biological_process innate immune response;GO:0050702,biological_process interleukin-1 beta secretion;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051260,biological_process protein homooligomerization;GO:0070269,biological_process pyroptosis;GO:0072557,cellular_component IPAF inflammasome complex;GO:1990001,biological_process inhibition of cysteine-type endopeptidase activity involved in apoptotic process	NLRC4, CARD12; NLR family CARD domain-containing protein 4; K12805	NLR family CARD domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:16412]
ENSG00000070182	0.24	0.29	0.32	0.44	0.42	0.28	-0.409246928299692	1.33418992471094	0.118544056844789	0.455427848224811	14:64746282-64879883:-	SPTB	22;GO:0000165,biological_process MAPK cascade;GO:0003779,molecular_function actin binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007010,biological_process cytoskeleton organization;GO:0007411,biological_process axon guidance;GO:0008091,cellular_component spectrin;GO:0014731,cellular_component spectrin-associated cytoskeleton;GO:0015629,cellular_component actin cytoskeleton;GO:0030506,molecular_function ankyrin binding;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051015,molecular_function actin filament binding;GO:0051693,biological_process actin filament capping	NA	spectrin beta%2C erythrocytic [Source:HGNC Symbol%3BAcc:HGNC:11274]
ENSG00000106443	22.35	21.10	19.99	23.01	22.14	23.65	-0.105391717946568	5.97992517180226	0.118590233522082	0.45546428487302	7:10973871-11169630:+	PHF14	8;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005634,cellular_component nucleus;GO:0008285,biological_process negative regulation of cell proliferation;GO:0046872,molecular_function metal ion binding;GO:0048286,biological_process lung alveolus development;GO:0072201,biological_process negative regulation of mesenchymal cell proliferation;GO:2000584,biological_process negative regulation of platelet-derived growth factor receptor-alpha signaling pathway;GO:2000791,biological_process negative regulation of mesenchymal cell proliferation involved in lung development	NA	PHD finger protein 14 [Source:HGNC Symbol%3BAcc:HGNC:22203]
ENSG00000104442	42.33	42.13	40.19	47.79	43.21	45.13	-0.116301419496917	5.20778393229233	0.118707029173565	0.455594293679689	8:65602455-65634217:-	ARMC1	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0030001,biological_process metal ion transport;GO:0046872,molecular_function metal ion binding	NA	armadillo repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17684]
ENSG00000141738	2.55	2.49	2.14	1.82	2.11	1.96	0.294477175306938	1.93164676738885	0.118713084032156	0.455594293679689	17:39737926-39747291:+	GRB7	24;GO:0003723,molecular_function RNA binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0008289,molecular_function lipid binding;GO:0009967,biological_process positive regulation of signal transduction;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0034063,biological_process stress granule assembly;GO:0035091,molecular_function phosphatidylinositol binding;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0050900,biological_process leukocyte migration	NA	growth factor receptor bound protein 7 [Source:HGNC Symbol%3BAcc:HGNC:4567]
ENSG00000169398	65.25	63.16	63.41	68.17	70.59	67.37	-0.091856569062839	7.97859393176046	0.118806159742334	0.455594293679689	8:140657899-141002216:-	PTK2	90;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001525,biological_process angiogenesis;GO:0001568,biological_process blood vessel development;GO:0001570,biological_process vasculogenesis;GO:0001725,cellular_component stress fiber;GO:0001764,biological_process neuron migration;GO:0001890,biological_process placenta development;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003007,biological_process heart morphogenesis;GO:0003779,molecular_function actin binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007172,biological_process signal complex assembly;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0008432,molecular_function JUN kinase binding;GO:0009790,biological_process embryo development;GO:0010594,biological_process regulation of endothelial cell migration;GO:0010632,biological_process regulation of epithelial cell migration;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0021955,biological_process central nervous system neuron axonogenesis;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030010,biological_process establishment of cell polarity;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0038007,biological_process netrin-activated signaling pathway;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0040023,biological_process establishment of nucleus localization;GO:0042127,biological_process regulation of cell proliferation;GO:0042169,molecular_function SH2 domain binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043542,biological_process endothelial cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087,biological_process innate immune response;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046621,biological_process negative regulation of organ growth;GO:0046777,biological_process protein autophosphorylation;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048870,biological_process cell motility;GO:0050771,biological_process negative regulation of axonogenesis;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051964,biological_process negative regulation of synapse assembly;GO:0060396,biological_process growth hormone receptor signaling pathway;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0097194,biological_process execution phase of apoptosis;GO:1900024,biological_process regulation of substrate adhesion-dependent cell spreading;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000811,biological_process negative regulation of anoikis	PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]; K05725	protein tyrosine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:9611]
ENSG00000165806	19.05	16.16	17.33	20.68	17.58	20.50	-0.145259973038645	4.68321209855793	0.118811326679105	0.455594293679689	10:113679161-113730907:+	CASP7	23;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0007507,biological_process heart development;GO:0007568,biological_process aging;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0009411,biological_process response to UV;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051402,biological_process neuron apoptotic process;GO:0072734,biological_process cellular response to staurosporine;GO:0097153,molecular_function cysteine-type endopeptidase activity involved in apoptotic process;GO:0097194,biological_process execution phase of apoptosis;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis	CASP7; caspase 7 [EC:3.4.22.60]; K04397	caspase 7 [Source:HGNC Symbol%3BAcc:HGNC:1508]
ENSG00000197122	21.76	21.51	22.72	19.57	20.48	21.41	0.115232592671668	5.11734894797517	0.118866651917127	0.455594293679689	20:37344684-37406050:+	SRC	172;GO:0000166,molecular_function nucleotide binding;GO:0002102,cellular_component podosome;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005080,molecular_function protein kinase C binding;GO:0005102,molecular_function receptor binding;GO:0005158,molecular_function insulin receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005764,cellular_component lysosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007172,biological_process signal complex assembly;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0009612,biological_process response to mechanical stimulus;GO:0009615,biological_process response to virus;GO:0010447,biological_process response to acidic pH;GO:0010628,biological_process positive regulation of gene expression;GO:0010632,biological_process regulation of epithelial cell migration;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010641,biological_process positive regulation of platelet-derived growth factor receptor signaling pathway;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0010954,biological_process positive regulation of protein processing;GO:0014069,cellular_component postsynaptic density;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0020037,molecular_function heme binding;GO:0022407,biological_process regulation of cell-cell adhesion;GO:0030168,biological_process platelet activation;GO:0030331,molecular_function estrogen receptor binding;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0030900,biological_process forebrain development;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031295,biological_process T cell costimulation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031648,biological_process protein destabilization;GO:0031667,biological_process response to nutrient levels;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032148,biological_process activation of protein kinase B activity;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032403,molecular_function protein complex binding;GO:0032463,biological_process negative regulation of protein homooligomerization;GO:0032587,cellular_component ruffle membrane;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0033625,biological_process positive regulation of integrin activation;GO:0034332,biological_process adherens junction organization;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035556,biological_process intracellular signal transduction;GO:0035635,biological_process entry of bacterium into host cell;GO:0036035,biological_process osteoclast development;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042169,molecular_function SH2 domain binding;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043114,biological_process regulation of vascular permeability;GO:0043149,biological_process stress fiber assembly;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043393,biological_process regulation of protein binding;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0044325,molecular_function ion channel binding;GO:0045056,biological_process transcytosis;GO:0045087,biological_process innate immune response;GO:0045124,biological_process regulation of bone resorption;GO:0045296,molecular_function cadherin binding;GO:0045453,biological_process bone resorption;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0046777,biological_process protein autophosphorylation;GO:0046875,molecular_function ephrin receptor binding;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048477,biological_process oogenesis;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050847,biological_process progesterone receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0051057,biological_process positive regulation of small GTPase mediated signal transduction;GO:0051219,molecular_function phosphoprotein binding;GO:0051222,biological_process positive regulation of protein transport;GO:0051385,biological_process response to mineralocorticoid;GO:0051427,molecular_function hormone receptor binding;GO:0051602,biological_process response to electrical stimulus;GO:0051726,biological_process regulation of cell cycle;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051902,biological_process negative regulation of mitochondrial depolarization;GO:0051974,biological_process negative regulation of telomerase activity;GO:0060065,biological_process uterus development;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0060491,biological_process regulation of cell projection assembly;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070542,biological_process response to fatty acid;GO:0070555,biological_process response to interleukin-1;GO:0070851,molecular_function growth factor receptor binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071253,molecular_function connexin binding;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071393,biological_process cellular response to progesterone stimulus;GO:0071398,biological_process cellular response to fatty acid;GO:0071456,biological_process cellular response to hypoxia;GO:0071498,biological_process cellular response to fluid shear stress;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071801,biological_process regulation of podosome assembly;GO:0071803,biological_process positive regulation of podosome assembly;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0086098,biological_process angiotensin-activated signaling pathway involved in heart process;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097110,molecular_function scaffold protein binding;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1902533,biological_process positive regulation of intracellular signal transduction;GO:2000394,biological_process positive regulation of lamellipodium morphogenesis;GO:2000573,biological_process positive regulation of DNA biosynthetic process;GO:2000641,biological_process regulation of early endosome to late endosome transport;GO:2000811,biological_process negative regulation of anoikis;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway;GO:2001286,biological_process regulation of caveolin-mediated endocytosis	SRC; tyrosine-protein kinase Src [EC:2.7.10.2]; K05704	SRC proto-oncogene%2C non-receptor tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:11283]
ENSG00000163684	10.63	14.39	17.41	17.11	19.57	15.88	-0.298987795009937	2.59536699495237	0.118905996299076	0.455594293679689	3:58306246-58324695:+	RPP14	12;GO:0001682,biological_process tRNA 5'-leader removal;GO:0003723,molecular_function RNA binding;GO:0004526,molecular_function ribonuclease P activity;GO:0004540,molecular_function ribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006364,biological_process rRNA processing;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0030681,cellular_component multimeric ribonuclease P complex;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	ribonuclease P/MRP subunit p14 [Source:HGNC Symbol%3BAcc:HGNC:30327]
ENSG00000059573	52.77	54.57	53.85	49.04	52.44	50.36	0.0976590061127623	6.96147891983056	0.118907245316533	0.455594293679689	10:95605928-95656706:-	ALDH18A1	26;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004349,molecular_function glutamate 5-kinase activity;GO:0004350,molecular_function glutamate-5-semialdehyde dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006536,biological_process glutamate metabolic process;GO:0006561,biological_process proline biosynthetic process;GO:0006592,biological_process ornithine biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016491,molecular_function oxidoreductase activity;GO:0016740,molecular_function transferase activity;GO:0017084,molecular_function delta1-pyrroline-5-carboxylate synthetase activity;GO:0019240,biological_process citrulline biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0055114,biological_process oxidation-reduction process;GO:0055129,biological_process L-proline biosynthetic process	ALDH18A1, P5CS; delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41]; K12657	aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:9722]
ENSG00000182149	79.72	73.78	77.02	84.28	80.21	84.89	-0.100401046954725	6.64744551451066	0.118917708170643	0.455594293679689	16:71845995-71931199:+	IST1	35;GO:0000785,cellular_component chromatin;GO:0000910,biological_process cytokinesis;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0008104,biological_process protein localization;GO:0009838,biological_process abscission;GO:0015031,biological_process protein transport;GO:0019076,biological_process viral release from host cell;GO:0019904,molecular_function protein domain specific binding;GO:0030496,cellular_component midbody;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032403,molecular_function protein complex binding;GO:0035578,cellular_component azurophil granule lumen;GO:0036258,biological_process multivesicular body assembly;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045184,biological_process establishment of protein localization;GO:0045296,molecular_function cadherin binding;GO:0045862,biological_process positive regulation of proteolysis;GO:0046745,biological_process viral capsid secondary envelopment;GO:0048672,biological_process positive regulation of collateral sprouting;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0090541,molecular_function MIT domain binding;GO:0090543,cellular_component Flemming body;GO:1904903,biological_process ESCRT III complex disassembly	NA	IST1%2C ESCRT-III associated factor [Source:HGNC Symbol%3BAcc:HGNC:28977]
ENSG00000157349	9.93	9.97	12.68	13.43	11.69	12.11	-0.17709852780503	4.18385296822062	0.119187685252149	0.456487731266563	16:70289662-70335283:+	DDX19B	23;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0010468,biological_process regulation of gene expression;GO:0010501,biological_process RNA secondary structure unwinding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031965,cellular_component nuclear membrane;GO:0051028,biological_process mRNA transport;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	DEAD-box helicase 19B [Source:HGNC Symbol%3BAcc:HGNC:2742]
ENSG00000077312	72.68	71.15	74.28	78.96	80.86	76.04	-0.0997017611137548	6.03043312076913	0.119278942582584	0.456696333830235	19:40750636-40765389:+	SNRPA	16;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005685,cellular_component U1 snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030619,molecular_function U1 snRNA binding;GO:0035614,molecular_function snRNA stem-loop binding;GO:0042802,molecular_function identical protein binding;GO:1900363,biological_process regulation of mRNA polyadenylation;GO:1990446,molecular_function U1 snRNP binding	SNRPA; U1 small nuclear ribonucleoprotein A; K11091	small nuclear ribonucleoprotein polypeptide A [Source:HGNC Symbol%3BAcc:HGNC:11151]
ENSG00000134802	121.49	117.06	120.19	131.37	124.45	130.17	-0.093513018253282	7.5543941700879	0.119390584345434	0.456982831785345	11:57406953-57427580:-	SLC43A3	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 43 member 3 [Source:HGNC Symbol%3BAcc:HGNC:17466]
ENSG00000147862	12.45	11.67	12.29	11.95	10.96	10.49	0.139917103767769	4.48969978977174	0.119560339200111	0.457461742151872	9:14081842-14398983:-	NFIB	33;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0002062,biological_process chondrocyte differentiation;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010001,biological_process glial cell differentiation;GO:0021740,biological_process principal sensory nucleus of trigeminal nerve development;GO:0021960,biological_process anterior commissure morphogenesis;GO:0030324,biological_process lung development;GO:0030900,biological_process forebrain development;GO:0030902,biological_process hindbrain development;GO:0044300,cellular_component cerebellar mossy fiber;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060486,biological_process Clara cell differentiation;GO:0060509,biological_process Type I pneumocyte differentiation;GO:0060510,biological_process Type II pneumocyte differentiation;GO:0060662,biological_process salivary gland cavitation;GO:0060689,biological_process cell differentiation involved in salivary gland development;GO:0061141,biological_process lung ciliated cell differentiation;GO:0071679,biological_process commissural neuron axon guidance;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:2000791,biological_process negative regulation of mesenchymal cell proliferation involved in lung development;GO:2000795,biological_process negative regulation of epithelial cell proliferation involved in lung morphogenesis	NA	nuclear factor I B [Source:HGNC Symbol%3BAcc:HGNC:7785]
ENSG00000107789	12.14	15.92	13.24	12.92	11.47	12.42	0.167794358254831	4.28684967840964	0.119589410560124	0.457461742151872	10:87504874-87553460:+	MINPP1	18;GO:0001503,biological_process ossification;GO:0003993,molecular_function acid phosphatase activity;GO:0004446,molecular_function inositol-hexakisphosphate phosphatase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006797,biological_process polyphosphate metabolic process;GO:0008969,molecular_function phosphohistidine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030282,biological_process bone mineralization;GO:0030351,molecular_function inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity;GO:0034417,molecular_function bisphosphoglycerate 3-phosphatase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0051717,molecular_function inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity;GO:0052745,molecular_function inositol phosphate phosphatase activity;GO:0052826,molecular_function inositol hexakisphosphate 2-phosphatase activity;GO:0070062,cellular_component extracellular exosome	MINPP1; multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase [EC:3.1.3.62 3.1.3.80]; K03103	multiple inositol-polyphosphate phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:7102]
ENSG00000181788	26.01	26.94	27.26	25.03	23.10	25.75	0.128137663542571	4.65031392456475	0.119669169533718	0.457625816827493	3:150741126-150763477:-	SIAH2	32;GO:0000209,biological_process protein polyubiquitination;GO:0003714,molecular_function transcription corepressor activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044257,biological_process cellular protein catabolic process;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	siah E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:10858]
ENSG00000178741	89.71	78.80	81.99	78.68	79.04	76.12	0.114976410661953	5.53038091289996	0.119739117614691	0.457687759030462	15:74919790-74938168:-	COX5A	12;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0043209,cellular_component myelin sheath;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1902600,biological_process hydrogen ion transmembrane transport	COX5A; cytochrome c oxidase subunit 5a; K02264	cytochrome c oxidase subunit 5A [Source:HGNC Symbol%3BAcc:HGNC:2267]
ENSG00000092929	0.30	0.30	0.77	0.32	0.24	0.36	0.607666909305939	0.591571330394219	0.119759110717066	0.457687759030462	17:75827224-75844717:-	UNC13D	25;GO:0002432,biological_process granuloma formation;GO:0002467,biological_process germinal center formation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006887,biological_process exocytosis;GO:0006909,biological_process phagocytosis;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0033093,cellular_component Weibel-Palade body;GO:0035578,cellular_component azurophil granule lumen;GO:0043304,biological_process regulation of mast cell degranulation;GO:0043312,biological_process neutrophil degranulation;GO:0043320,biological_process natural killer cell degranulation;GO:0045921,biological_process positive regulation of exocytosis;GO:0051607,biological_process defense response to virus;GO:0055037,cellular_component recycling endosome;GO:0070382,cellular_component exocytic vesicle;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1903307,biological_process positive regulation of regulated secretory pathway	BAIAP3; BAI1-associated protein 3; K15621	unc-13 homolog D [Source:HGNC Symbol%3BAcc:HGNC:23147]
ENSG00000144043	9.49	12.68	9.76	12.35	14.06	11.60	-0.25491562769766	2.80234671846157	0.119855022481528	0.457913325350324	2:70985937-70994945:-	TEX261	7;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0097020,molecular_function COPII adaptor activity	NA	testis expressed 261 [Source:HGNC Symbol%3BAcc:HGNC:30712]
ENSG00000113838	11.01	8.28	10.88	11.06	11.91	11.41	-0.164887086191119	4.22940199555012	0.119970478388158	0.458158071095486	3:186546072-186570543:-	TBCCD1	11;GO:0000922,cellular_component spindle pole;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0030334,biological_process regulation of cell migration;GO:0031616,cellular_component spindle pole centrosome;GO:0051661,biological_process maintenance of centrosome location;GO:0051684,biological_process maintenance of Golgi location	NA	TBCC domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25546]
ENSG00000136231	43.22	42.47	46.27	46.16	48.12	48.50	-0.100658304850436	6.31804144346899	0.119992901726531	0.458158071095486	7:23310208-23470467:-	IGF2BP3	17;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0009653,biological_process anatomical structure morphogenesis;GO:0017148,biological_process negative regulation of translation;GO:0042035,biological_process regulation of cytokine biosynthetic process;GO:0043488,biological_process regulation of mRNA stability;GO:0045182,molecular_function translation regulator activity;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0051028,biological_process mRNA transport	NA	insulin like growth factor 2 mRNA binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:28868]
ENSG00000255112	104.46	94.12	110.34	114.75	109.00	113.07	-0.10938903377427	6.01193761737245	0.120130472009962	0.458306185746731	18:11851395-11854449:+	CHMP1B	27;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0010008,cellular_component endosome membrane;GO:0010824,biological_process regulation of centrosome duplication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030117,cellular_component membrane coat;GO:0030496,cellular_component midbody;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0045184,biological_process establishment of protein localization;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1904903,biological_process ESCRT III complex disassembly	NA	charged multivesicular body protein 1B [Source:HGNC Symbol%3BAcc:HGNC:24287]
ENSG00000105559	8.01	6.87	7.62	8.94	7.30	9.33	-0.168354856361551	4.24482017551063	0.120134015042171	0.458306185746731	19:48837096-48868632:-	PLEKHA4	8;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008150,biological_process biological_process;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding	NA	pleckstrin homology domain containing A4 [Source:HGNC Symbol%3BAcc:HGNC:14339]
ENSG00000147874	37.41	37.29	37.74	39.09	39.81	42.46	-0.0985467267459395	6.80992229650345	0.120142457779736	0.458306185746731	9:19053142-19103119:-	HAUS6	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016607,cellular_component nuclear speck;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:25948]
ENSG00000075218	15.16	18.54	14.61	17.80	20.35	16.24	-0.164324316735817	5.24910039560883	0.120374867107139	0.458989288241699	22:46296740-46330810:+	GTSE1	18;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007017,biological_process microtubule-based process;GO:0016020,cellular_component membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0050821,biological_process protein stabilization;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1902749,biological_process regulation of cell cycle G2/M phase transition;GO:1904527,biological_process negative regulation of microtubule binding	GTSE1, B99; G-2 and S-phase expressed protein 1; K10129	G2 and S-phase expressed 1 [Source:HGNC Symbol%3BAcc:HGNC:13698]
ENSG00000154080	17.32	17.47	16.56	17.92	23.34	17.25	-0.175813733290531	4.61442944942104	0.120395482358412	0.458989288241699	18:26906480-27185317:-	CHST9	16;GO:0000139,cellular_component Golgi membrane;GO:0001537,molecular_function N-acetylgalactosamine 4-O-sulfotransferase activity;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006790,biological_process sulfur compound metabolic process;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016051,biological_process carbohydrate biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0030166,biological_process proteoglycan biosynthetic process;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0042446,biological_process hormone biosynthetic process;GO:0047756,molecular_function chondroitin 4-sulfotransferase activity	CHST9; carbohydrate 4-sulfotransferase 9 [EC:2.8.2.-]; K09673	carbohydrate sulfotransferase 9 [Source:HGNC Symbol%3BAcc:HGNC:19898]
ENSG00000069696	1.80	2.05	1.35	1.07	1.39	1.40	0.420371097467423	1.02022344068951	0.120435606698131	0.459001285214582	11:637292-640706:+	DRD4	42;GO:0000187,biological_process activation of MAPK activity;GO:0001591,molecular_function dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0001662,biological_process behavioral fear response;GO:0001975,biological_process response to amphetamine;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004952,molecular_function dopamine neurotransmitter receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007194,biological_process negative regulation of adenylate cyclase activity;GO:0007195,biological_process adenylate cyclase-inhibiting dopamine receptor signaling pathway;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0008144,molecular_function drug binding;GO:0008344,biological_process adult locomotory behavior;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030818,biological_process negative regulation of cAMP biosynthetic process;GO:0032417,biological_process positive regulation of sodium:proton antiporter activity;GO:0033674,biological_process positive regulation of kinase activity;GO:0034776,biological_process response to histamine;GO:0035176,biological_process social behavior;GO:0035240,molecular_function dopamine binding;GO:0042053,biological_process regulation of dopamine metabolic process;GO:0042417,biological_process dopamine metabolic process;GO:0042596,biological_process fear response;GO:0042752,biological_process regulation of circadian rhythm;GO:0042802,molecular_function identical protein binding;GO:0048148,biological_process behavioral response to cocaine;GO:0048149,biological_process behavioral response to ethanol;GO:0048511,biological_process rhythmic process;GO:0050482,biological_process arachidonic acid secretion;GO:0050709,biological_process negative regulation of protein secretion;GO:0051586,biological_process positive regulation of dopamine uptake involved in synaptic transmission;GO:0060080,biological_process inhibitory postsynaptic potential;GO:0098794,cellular_component postsynapse;GO:1901386,biological_process negative regulation of voltage-gated calcium channel activity	DRD4; dopamine receptor D4; K04147	dopamine receptor D4 [Source:HGNC Symbol%3BAcc:HGNC:3025]
ENSG00000160685	21.45	19.85	22.52	20.25	19.24	19.88	0.120065592022308	5.14947898013996	0.120500449276622	0.459107451464306	1:155002629-155018522:+	ZBTB7B	20;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007398,biological_process ectoderm development;GO:0010628,biological_process positive regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0042803,molecular_function protein homodimerization activity;GO:0043370,biological_process regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043376,biological_process regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 7B [Source:HGNC Symbol%3BAcc:HGNC:18668]
ENSG00000157036	8.46	8.85	7.82	10.70	8.60	9.55	-0.192111772065265	3.5141176824119	0.120567452724322	0.459221782960114	3:38496126-38542161:+	EXOG	14;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008150,biological_process biological_process;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	exo/endonuclease G [Source:HGNC Symbol%3BAcc:HGNC:3347]
ENSG00000072121	5.39	5.87	5.69	5.30	5.49	4.98	0.113736639891116	5.40229546839141	0.120682663082115	0.459519600257144	14:67727373-67816590:-	ZFYVE26	16;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000910,biological_process cytokinesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008289,molecular_function lipid binding;GO:0030496,cellular_component midbody;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	NA	zinc finger FYVE-type containing 26 [Source:HGNC Symbol%3BAcc:HGNC:20761]
ENSG00000113575	98.52	99.14	92.11	108.22	98.29	107.75	-0.1063022364225	6.64216411588488	0.120868151655961	0.460037435340853	5:134194333-134226142:-	PPP2CA	40;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000188,biological_process inactivation of MAPK activity;GO:0000775,cellular_component chromosome, centromeric region;GO:0000922,cellular_component spindle pole;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006275,biological_process regulation of DNA replication;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006470,biological_process protein dephosphorylation;GO:0006672,biological_process ceramide metabolic process;GO:0006915,biological_process apoptotic process;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0007498,biological_process mesoderm development;GO:0008022,molecular_function protein C-terminus binding;GO:0008380,biological_process RNA splicing;GO:0010033,biological_process response to organic substance;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019932,biological_process second-messenger-mediated signaling;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030155,biological_process regulation of cell adhesion;GO:0030308,biological_process negative regulation of cell growth;GO:0040008,biological_process regulation of growth;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0045595,biological_process regulation of cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0050811,molecular_function GABA receptor binding;GO:0051321,biological_process meiotic cell cycle;GO:0070062,cellular_component extracellular exosome;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity	PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]; K04382	protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:9299]
ENSG00000156510	68.73	57.11	68.09	70.82	67.76	73.64	-0.116788208997122	7.54390407779677	0.120939355329063	0.460037435340853	10:69220302-69267559:+	HKDC1	19;GO:0000166,molecular_function nucleotide binding;GO:0001678,biological_process cellular glucose homeostasis;GO:0004340,molecular_function glucokinase activity;GO:0004396,molecular_function hexokinase activity;GO:0005524,molecular_function ATP binding;GO:0005536,molecular_function glucose binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006096,biological_process glycolytic process;GO:0008865,molecular_function fructokinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019158,molecular_function mannokinase activity;GO:0019318,biological_process hexose metabolic process;GO:0046835,biological_process carbohydrate phosphorylation;GO:0051156,biological_process glucose 6-phosphate metabolic process	HK; hexokinase [EC:2.7.1.1]; K00844	hexokinase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23302]
ENSG00000141232	22.52	22.44	22.04	23.80	24.99	24.87	-0.125384650409623	4.61145840572286	0.120962588437218	0.460037435340853	17:50862222-50867978:-	TOB1	19;GO:0003714,molecular_function transcription corepressor activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007184,biological_process SMAD protein import into nucleus;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009967,biological_process positive regulation of signal transduction;GO:0017148,biological_process negative regulation of translation;GO:0030014,cellular_component CCR4-NOT complex;GO:0030509,biological_process BMP signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0046332,molecular_function SMAD binding;GO:0060212,biological_process negative regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	TOB; protein Tob/BTG; K14443	transducer of ERBB2%2C 1 [Source:HGNC Symbol%3BAcc:HGNC:11979]
ENSG00000213190	29.30	35.39	29.99	24.96	32.02	23.96	0.230544807916879	2.99976948661296	0.120979145667814	0.460037435340853	1:151057757-151068497:+	MLLT11	15;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051901,biological_process positive regulation of mitochondrial depolarization;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097193,biological_process intrinsic apoptotic signaling pathway	NA	MLLT11%2C transcription factor 7 cofactor [Source:HGNC Symbol%3BAcc:HGNC:16997]
ENSG00000075914	46.68	43.35	41.99	48.80	45.44	50.02	-0.115429036751744	5.3367863767271	0.121003965712389	0.460037435340853	3:44975240-45036066:+	EXOSC7	25;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000467,biological_process exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006401,biological_process RNA catabolic process;GO:0017091,molecular_function AU-rich element binding;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034473,biological_process U1 snRNA 3'-end processing;GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0034476,biological_process U5 snRNA 3'-end processing;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071035,biological_process nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038,biological_process nuclear polyadenylation-dependent tRNA catabolic process;GO:0071042,biological_process nuclear polyadenylation-dependent mRNA catabolic process	RRP42, EXOSC7; exosome complex component RRP42; K12589	exosome component 7 [Source:HGNC Symbol%3BAcc:HGNC:28112]
ENSG00000007520	37.05	37.78	35.39	37.44	38.81	45.30	-0.132336816499527	5.18381373990995	0.121065606508266	0.460127304356982	16:1349239-1351911:-	TSR3	6;GO:0000154,biological_process rRNA modification;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0016740,molecular_function transferase activity;GO:0030490,biological_process maturation of SSU-rRNA;GO:0042254,biological_process ribosome biogenesis	NA	TSR3%2C acp transferase ribosome maturation factor [Source:HGNC Symbol%3BAcc:HGNC:14175]
ENSG00000005339	14.32	13.51	13.68	15.41	15.27	14.24	-0.10119230779753	6.74497953074339	0.12111030763201	0.460127304356982	16:3725053-3880726:-	CREBBP	57;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000790,cellular_component nuclear chromatin;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001191,molecular_function transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0001666,biological_process response to hypoxia;GO:0002039,molecular_function p53 binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006473,biological_process protein acetylation;GO:0007165,biological_process signal transduction;GO:0007219,biological_process Notch signaling pathway;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0016032,biological_process viral process;GO:0016407,molecular_function acetyltransferase activity;GO:0016573,biological_process histone acetylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018076,biological_process N-terminal peptidyl-lysine acetylation;GO:0019216,biological_process regulation of lipid metabolic process;GO:0031648,biological_process protein destabilization;GO:0032481,biological_process positive regulation of type I interferon production;GO:0034212,molecular_function peptide N-acetyltransferase activity;GO:0034644,biological_process cellular response to UV;GO:0042592,biological_process homeostatic process;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042981,biological_process regulation of apoptotic process;GO:0043426,molecular_function MRF binding;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:1900034,biological_process regulation of cellular response to heat;GO:1904837,biological_process beta-catenin-TCF complex assembly	EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]; K04498	CREB binding protein [Source:HGNC Symbol%3BAcc:HGNC:2348]
ENSG00000151090	9.58	9.10	9.12	7.26	8.42	9.25	0.168383563183275	3.92589118413393	0.121138808558657	0.460127304356982	3:24117159-24495282:-	THRB	33;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004887,molecular_function thyroid hormone receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007605,biological_process sensory perception of sound;GO:0007621,biological_process negative regulation of female receptivity;GO:0008016,biological_process regulation of heart contraction;GO:0008050,biological_process female courtship behavior;GO:0008270,molecular_function zinc ion binding;GO:0009887,biological_process organ morphogenesis;GO:0016604,cellular_component nuclear body;GO:0019899,molecular_function enzyme binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0031490,molecular_function chromatin DNA binding;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060509,biological_process Type I pneumocyte differentiation;GO:0070062,cellular_component extracellular exosome;GO:0070324,molecular_function thyroid hormone binding	THRB, NR1A2; thyroid hormone receptor beta; K08362	thyroid hormone receptor beta [Source:HGNC Symbol%3BAcc:HGNC:11799]
ENSG00000106025	16.37	20.33	15.81	14.02	17.50	14.58	0.190737419311648	3.9624709604471	0.121213894405062	0.460271664499856	7:120787319-120858402:-	TSPAN12	9;GO:0001525,biological_process angiogenesis;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0010842,biological_process retina layer formation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045765,biological_process regulation of angiogenesis	NA	tetraspanin 12 [Source:HGNC Symbol%3BAcc:HGNC:21641]
ENSG00000139266	12.59	11.91	14.03	15.81	13.39	14.33	-0.159741982380288	4.0689431205926	0.121362312159799	0.460663259578202	12:57755097-57760407:+	MARCH9	12;GO:0000139,cellular_component Golgi membrane;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005802,cellular_component trans-Golgi network;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	membrane associated ring-CH-type finger 9 [Source:HGNC Symbol%3BAcc:HGNC:25139]
ENSG00000099875	155.77	116.50	165.67	185.89	136.57	183.02	-0.194551296863293	7.94686857883333	0.121411566374755	0.460663259578202	19:2037464-2051244:-	MKNK2	27;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009931,molecular_function calcium-dependent protein serine/threonine kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030097,biological_process hemopoiesis;GO:0035556,biological_process intracellular signal transduction;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand	MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]; K04372	MAP kinase interacting serine/threonine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:7111]
ENSG00000052723	27.67	20.23	21.05	25.79	26.00	27.66	-0.184055195452885	3.99079427424563	0.121428356186246	0.460663259578202	1:114769478-114780685:-	SIKE1	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	SIKE; suppressor of IKK-epsilon; K12656	suppressor of IKBKE 1 [Source:HGNC Symbol%3BAcc:HGNC:26119]
ENSG00000100211	61.85	57.30	52.99	51.24	53.25	54.09	0.130448868984543	4.81278516096085	0.121481384512248	0.460683592926382	22:38656635-38673854:+	CBY1	25;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008013,molecular_function beta-catenin binding;GO:0008104,biological_process protein localization;GO:0016607,cellular_component nuclear speck;GO:0030030,biological_process cell projection organization;GO:0030154,biological_process cell differentiation;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0036064,cellular_component ciliary basal body;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0045444,biological_process fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051289,biological_process protein homotetramerization;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060271,biological_process cilium morphogenesis;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	chibby family member 1%2C beta catenin antagonist [Source:HGNC Symbol%3BAcc:HGNC:1307]
ENSG00000078902	41.17	44.33	40.28	37.31	41.25	38.01	0.117927800616962	5.18674978773473	0.121507941935147	0.460683592926382	11:1274370-1309654:-	TOLLIP	33;GO:0002376,biological_process immune system process;GO:0004871,molecular_function signal transducer activity;GO:0005150,molecular_function interleukin-1, Type I receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006914,biological_process autophagy;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0019900,molecular_function kinase binding;GO:0030855,biological_process epithelial cell differentiation;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032183,molecular_function SUMO binding;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0035325,molecular_function Toll-like receptor binding;GO:0035556,biological_process intracellular signal transduction;GO:0035578,cellular_component azurophil granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0036010,biological_process protein localization to endosome;GO:0043130,molecular_function ubiquitin binding;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0045092,cellular_component interleukin-18 receptor complex;GO:0045321,biological_process leukocyte activation;GO:0045323,cellular_component interleukin-1 receptor complex;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	TOLLIP; toll-interacting protein; K05402	toll interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16476]
ENSG00000063761	3.93	3.86	3.85	3.66	3.49	2.80	0.24199605188666	2.69285920127614	0.121635102019634	0.461024892021289	14:77800082-77935012:+	ADCK1	8;GO:0000166,molecular_function nucleotide binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	aarF domain containing kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:19038]
ENSG00000137269	9.38	11.61	9.59	8.72	9.89	8.55	0.174677449366526	3.94056000740911	0.121771583912289	0.461214597794664	6:53794496-53924121:+	LRRC1	5;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane	NA	leucine rich repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14307]
ENSG00000169554	13.09	12.59	14.41	12.77	12.47	12.24	0.111176774169274	5.81645026498907	0.121827429629265	0.461214597794664	2:144364363-144524583:-	ZEB2	37;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001755,biological_process neural crest cell migration;GO:0001756,biological_process somitogenesis;GO:0001843,biological_process neural tube closure;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0007417,biological_process central nervous system development;GO:0019208,molecular_function phosphatase regulator activity;GO:0021540,biological_process corpus callosum morphogenesis;GO:0021766,biological_process hippocampus development;GO:0021846,biological_process cell proliferation in forebrain;GO:0021957,biological_process corticospinal tract morphogenesis;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045636,biological_process positive regulation of melanocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048023,biological_process positive regulation of melanin biosynthetic process;GO:0048066,biological_process developmental pigmentation;GO:0048598,biological_process embryonic morphogenesis;GO:0048668,biological_process collateral sprouting;GO:0050772,biological_process positive regulation of axonogenesis;GO:0061373,biological_process mammillary axonal complex development;GO:0070412,molecular_function R-SMAD binding;GO:0097324,biological_process melanocyte migration;GO:1902748,biological_process positive regulation of lens fiber cell differentiation;GO:1903056,biological_process regulation of melanosome organization	ZEB1; zinc finger homeobox protein 1; K09299	zinc finger E-box binding homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:14881]
ENSG00000166165	20.31	10.52	19.34	14.76	11.71	15.18	0.287757778804712	4.19140220036889	0.121836523975046	0.461214597794664	14:103519658-103523111:-	CKB	24;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004111,molecular_function creatine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006600,biological_process creatine metabolic process;GO:0007420,biological_process brain development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0021549,biological_process cerebellum development;GO:0021762,biological_process substantia nigra development;GO:0030425,cellular_component dendrite;GO:0030644,biological_process cellular chloride ion homeostasis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043025,cellular_component neuronal cell body;GO:0043209,cellular_component myelin sheath;GO:0070062,cellular_component extracellular exosome	E2.7.3.2; creatine kinase [EC:2.7.3.2]; K00933	creatine kinase B [Source:HGNC Symbol%3BAcc:HGNC:1991]
ENSG00000135842	48.35	38.91	53.34	55.40	46.90	55.77	-0.155548119609261	7.13844816899434	0.121870616141129	0.461214597794664	1:184790723-184974550:-	FAM129A	12;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006417,biological_process regulation of translation;GO:0016020,cellular_component membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0045727,biological_process positive regulation of translation;GO:0070062,cellular_component extracellular exosome	NA	family with sequence similarity 129 member A [Source:HGNC Symbol%3BAcc:HGNC:16784]
ENSG00000177614	4.96	4.79	4.99	4.06	4.52	4.35	0.202408038703077	2.99458542487497	0.121870932149078	0.461214597794664	1:230314481-230426371:-	PGBD5	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	piggyBac transposable element derived 5 [Source:HGNC Symbol%3BAcc:HGNC:19405]
ENSG00000082805	14.76	14.18	12.95	15.30	16.16	14.37	-0.1175951667913	5.6617713961443	0.12203118435899	0.461624067610082	12:990508-1495933:+	ERC1	21;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0007252,biological_process I-kappaB phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0008385,cellular_component IkappaB kinase complex;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030165,molecular_function PDZ domain binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042734,cellular_component presynaptic membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043522,molecular_function leucine zipper domain binding;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0048786,cellular_component presynaptic active zone;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	ERC1, CAST2, ELKS; ELKS/RAB6-interacting/CAST family member 1; K16072	ELKS/RAB6-interacting/CAST family member 1 [Source:HGNC Symbol%3BAcc:HGNC:17072]
ENSG00000168118	48.06	45.30	42.65	45.34	40.47	39.03	0.136534589552965	4.83696205361682	0.122053507604631	0.461624067610082	1:229271061-229305894:+	RAB4A	32;GO:0000166,molecular_function nucleotide binding;GO:0001671,molecular_function ATPase activator activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0019882,biological_process antigen processing and presentation;GO:0019905,molecular_function syntaxin binding;GO:0030100,biological_process regulation of endocytosis;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031901,cellular_component early endosome membrane;GO:0031982,cellular_component vesicle;GO:0032482,biological_process Rab protein signal transduction;GO:0032593,cellular_component insulin-responsive compartment;GO:0032781,biological_process positive regulation of ATPase activity;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051117,molecular_function ATPase binding;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0098837,cellular_component postsynaptic recycling endosome	RAB4A, RAB4; Ras-related protein Rab-4A; K07879	RAB4A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9781]
ENSG00000100991	44.51	44.57	47.07	40.68	44.60	42.67	0.101864836469885	6.72051524013214	0.122429355228015	0.462904534403091	20:35002403-35092871:-	TRPC4AP	9;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0019902,molecular_function phosphatase binding;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0048820,biological_process hair follicle maturation;GO:0070588,biological_process calcium ion transmembrane transport	NA	transient receptor potential cation channel subfamily C member 4 associated protein [Source:HGNC Symbol%3BAcc:HGNC:16181]
ENSG00000111912	8.03	6.85	8.02	7.77	8.94	8.92	-0.143719971749514	4.56731951684721	0.122496175067856	0.462962684817879	6:125781160-125932030:+	NCOA7	11;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1900408,biological_process negative regulation of cellular response to oxidative stress;GO:1902083,biological_process negative regulation of peptidyl-cysteine S-nitrosylation;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death	NA	nuclear receptor coactivator 7 [Source:HGNC Symbol%3BAcc:HGNC:21081]
ENSG00000086102	16.74	16.25	18.19	16.85	15.54	15.41	0.112162517181617	5.82955827375501	0.122519328093671	0.462962684817879	9:33290510-33371157:+	NFX1	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0008270,molecular_function zinc ion binding;GO:0016032,biological_process viral process;GO:0016874,molecular_function ligase activity;GO:0045347,biological_process negative regulation of MHC class II biosynthetic process;GO:0046872,molecular_function metal ion binding	NFX1; transcriptional repressor NF-X1; K12236	nuclear transcription factor%2C X-box binding 1 [Source:HGNC Symbol%3BAcc:HGNC:7803]
ENSG00000179409	12.35	13.40	11.03	11.90	10.80	11.11	0.128578000313652	5.23615277011866	0.122563644440637	0.462989202203782	17:744413-753999:-	GEMIN4	18;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0070062,cellular_component extracellular exosome;GO:0097504,cellular_component Gemini of coiled bodies	GEMIN4; gem associated protein 4; K13132	gem nuclear organelle associated protein 4 [Source:HGNC Symbol%3BAcc:HGNC:15717]
ENSG00000088986	600.53	627.15	617.50	664.93	648.50	668.65	-0.0919422677211415	7.74553482281006	0.122672806927453	0.463241462219737	12:120469849-120498493:+	DYNLL1	52;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000776,cellular_component kinetochore;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006915,biological_process apoptotic process;GO:0007017,biological_process microtubule-based process;GO:0007062,biological_process sister chromatid cohesion;GO:0008022,molecular_function protein C-terminus binding;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008180,cellular_component COP9 signalosome;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010970,biological_process establishment of localization by movement along microtubule;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016236,biological_process macroautophagy;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019904,molecular_function protein domain specific binding;GO:0021762,biological_process substantia nigra development;GO:0030286,cellular_component dynein complex;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042326,biological_process negative regulation of phosphorylation;GO:0043312,biological_process neutrophil degranulation;GO:0044458,biological_process motile cilium assembly;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0072686,cellular_component mitotic spindle;GO:0097542,cellular_component ciliary tip;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1902857,biological_process positive regulation of nonmotile primary cilium assembly;GO:2000582,biological_process positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	NA	dynein light chain LC8-type 1 [Source:HGNC Symbol%3BAcc:HGNC:15476]
ENSG00000090530	64.67	60.61	62.10	58.48	60.06	58.27	0.0964525614262098	7.01315517820164	0.122710542883362	0.463241462219737	3:189956727-190122437:-	P3H2	15;GO:0005506,molecular_function iron ion binding;GO:0005604,cellular_component basement membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0019511,biological_process peptidyl-proline hydroxylation;GO:0019797,molecular_function procollagen-proline 3-dioxygenase activity;GO:0031418,molecular_function L-ascorbic acid binding;GO:0032963,biological_process collagen metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	prolyl 3-hydroxylase 2 [Source:HGNC Symbol%3BAcc:HGNC:19317]
ENSG00000154978	39.79	42.17	40.54	38.67	37.62	36.86	0.123571244208737	4.65674908311971	0.1227597971792	0.463241462219737	7:55436055-55572988:-	VOPP1	10;GO:0004871,molecular_function signal transducer activity;GO:0005768,cellular_component endosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031301,cellular_component integral component of organelle membrane;GO:0031410,cellular_component cytoplasmic vesicle	NA	vesicular%2C overexpressed in cancer%2C prosurvival protein 1 [Source:HGNC Symbol%3BAcc:HGNC:34518]
ENSG00000153066	12.67	13.71	12.98	10.44	13.32	12.28	0.136558577243683	5.21912011655918	0.122779699565209	0.463241462219737	16:11679079-11742878:-	TXNDC11	10;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0045454,biological_process cell redox homeostasis	NA	thioredoxin domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:28030]
ENSG00000177854	8.57	8.91	9.68	8.03	6.88	8.44	0.227448065106559	2.75288801291982	0.122953977531339	0.463641442382784	X:153972326-153983195:+	TMEM187	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle	NA	transmembrane protein 187 [Source:HGNC Symbol%3BAcc:HGNC:13705]
ENSG00000171720	48.95	47.78	43.05	54.05	47.61	50.88	-0.115198814926989	5.97168951576705	0.123020641826046	0.463641442382784	5:141620875-141636870:-	HDAC3	41;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005876,cellular_component spindle microtubule;GO:0005886,cellular_component plasma membrane;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006476,biological_process protein deacetylation;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0030332,molecular_function cyclin binding;GO:0031647,biological_process regulation of protein stability;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033558,molecular_function protein deacetylase activity;GO:0042826,molecular_function histone deacetylase binding;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046329,biological_process negative regulation of JNK cascade;GO:0051059,molecular_function NF-kappaB binding;GO:0051225,biological_process spindle assembly;GO:0070932,biological_process histone H3 deacetylation;GO:0071498,biological_process cellular response to fluid shear stress	HDAC3; histone deacetylase 3 [EC:3.5.1.98]; K11404	histone deacetylase 3 [Source:HGNC Symbol%3BAcc:HGNC:4854]
ENSG00000133488	5.72	4.69	8.38	4.96	3.61	6.30	0.354989667890193	2.88922030741221	0.123030614803239	0.463641442382784	22:30488912-30505711:-	SEC14L4	6;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0016021,cellular_component integral component of membrane	NA	SEC14 like lipid binding 4 [Source:HGNC Symbol%3BAcc:HGNC:20627]
ENSG00000182504	3.83	4.53	4.50	4.32	5.74	4.84	-0.204131497538192	3.61522746400158	0.123035117313211	0.463641442382784	3:101723924-101770562:+	CEP97	12;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0043234,cellular_component protein complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1902018,biological_process negative regulation of cilium assembly	NA	centrosomal protein 97 [Source:HGNC Symbol%3BAcc:HGNC:26244]
ENSG00000162385	75.46	72.44	82.51	82.22	83.29	86.85	-0.116462254728299	5.14857278927274	0.123075175126118	0.463651638494842	1:53226891-53238610:-	MAGOH	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0035145,cellular_component exon-exon junction complex;GO:0051028,biological_process mRNA transport;GO:0071013,cellular_component catalytic step 2 spliceosome	MAGOH; protein mago nashi; K12877	mago homolog%2C exon junction complex core component [Source:HGNC Symbol%3BAcc:HGNC:6815]
ENSG00000101160	469.36	458.48	456.34	495.60	493.60	492.69	-0.0865840055912021	8.76366426282635	0.123208280428739	0.464012252719036	20:58995184-59007247:-	CTSZ	36;GO:0000139,cellular_component Golgi membrane;GO:0002003,biological_process angiotensin maturation;GO:0004180,molecular_function carboxypeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0009986,cellular_component cell surface;GO:0010757,biological_process negative regulation of plasminogen activation;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016787,molecular_function hydrolase activity;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030426,cellular_component growth cone;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032091,biological_process negative regulation of protein binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035580,cellular_component specific granule lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0048208,biological_process COPII vesicle coating;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0099738,cellular_component cell cortex region;GO:1901214,biological_process regulation of neuron death;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2000179,biological_process positive regulation of neural precursor cell proliferation	CTSZ; cathepsin X [EC:3.4.18.1]; K08568	cathepsin Z [Source:HGNC Symbol%3BAcc:HGNC:2547]
ENSG00000125844	63.73	69.02	58.29	56.34	64.39	56.35	0.120619012260919	8.02103692879198	0.123247724347581	0.46402001890401	20:17613677-17682295:-	RRBP1	12;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0004872,molecular_function receptor activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane	RRBP1; ribosome-binding protein 1; K14000	ribosome binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10448]
ENSG00000005100	9.22	7.98	9.13	9.28	10.76	9.51	-0.147648780764481	4.32016710313014	0.123301670876729	0.464082365249495	17:5440911-5469060:-	DHX33	15;GO:0000166,molecular_function nucleotide binding;GO:0000182,molecular_function rDNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0016787,molecular_function hydrolase activity;GO:0033613,molecular_function activating transcription factor binding;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter	NA	DEAH-box helicase 33 [Source:HGNC Symbol%3BAcc:HGNC:16718]
ENSG00000215695	7.17	8.11	8.15	8.01	8.89	9.54	-0.167697801080012	3.95885755746024	0.123530024762943	0.464727900974293	1:15659868-15661722:+	RSC1A1	12;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0008200,molecular_function ion channel inhibitor activity;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0051051,biological_process negative regulation of transport;GO:0065009,biological_process regulation of molecular function	NA	regulator of solute carriers 1 [Source:HGNC Symbol%3BAcc:HGNC:10458]
ENSG00000076641	18.20	16.15	17.38	16.35	15.10	16.06	0.139543503973836	4.43437347347533	0.123558893965595	0.464727900974293	8:80967809-81112068:-	PAG1	20;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0009967,biological_process positive regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035556,biological_process intracellular signal transduction;GO:0042169,molecular_function SH2 domain binding;GO:0045121,cellular_component membrane raft;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050863,biological_process regulation of T cell activation;GO:0050868,biological_process negative regulation of T cell activation	NA	phosphoprotein membrane anchor with glycosphingolipid microdomains 1 [Source:HGNC Symbol%3BAcc:HGNC:30043]
ENSG00000163682	959.45	836.82	869.38	1011.87	894.62	994.79	-0.110246300447979	9.15063475460617	0.123627585895124	0.464727900974293	4:39454123-39458948:-	RPL9	20;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix	RP-L9e, RPL9; large subunit ribosomal protein L9e; K02940	ribosomal protein L9 [Source:HGNC Symbol%3BAcc:HGNC:10369]
ENSG00000131149	19.06	17.85	18.49	19.78	19.83	20.09	-0.0947822785768765	6.91587447694327	0.123646199468757	0.464727900974293	16:85169524-85676204:+	GSE1	1;GO:0005515,molecular_function protein binding	NA	Gse1 coiled-coil protein [Source:HGNC Symbol%3BAcc:HGNC:28979]
ENSG00000132207	3.34	2.66	3.66	2.63	2.57	2.30	0.393531394270573	1.33362469557286	0.123660376775807	0.464727900974293	16:30193886-30197561:+	SLX1A	23;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0010792,biological_process DNA double-strand break processing involved in repair via single-strand annealing;GO:0010833,biological_process telomere maintenance via telomere lengthening;GO:0016787,molecular_function hydrolase activity;GO:0017108,molecular_function 5'-flap endonuclease activity;GO:0033557,cellular_component Slx1-Slx4 complex;GO:0036297,biological_process interstrand cross-link repair;GO:0046872,molecular_function metal ion binding;GO:0061820,biological_process telomeric D-loop disassembly;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090656,biological_process t-circle formation;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1904431,biological_process positive regulation of t-circle formation	SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]; K15078	SLX1 homolog A%2C structure-specific endonuclease subunit [Source:HGNC Symbol%3BAcc:HGNC:20922]
ENSG00000089195	11.46	13.78	13.23	14.51	12.97	15.80	-0.165424746176586	4.35558465134356	0.123723053644545	0.464822719397622	20:5937234-5950558:-	TRMT6	7;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0030488,biological_process tRNA methylation;GO:0031515,cellular_component tRNA (m1A) methyltransferase complex	NA	tRNA methyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:20900]
ENSG00000165023	9.23	9.76	8.14	6.77	8.13	7.89	0.25441127768462	2.3495567259594	0.123866280497202	0.465042178330119	9:90609831-90643105:-	DIRAS2	6;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane	NA	DIRAS family GTPase 2 [Source:HGNC Symbol%3BAcc:HGNC:19323]
ENSG00000179528	8.62	7.89	9.26	10.18	9.25	10.81	-0.213378979343055	2.91444073801408	0.123921921901837	0.465042178330119	2:74497516-74503316:-	LBX2	4;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	ladybird homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:15525]
ENSG00000019505	14.75	17.42	15.37	15.20	14.44	13.39	0.149193067206117	4.36005969288153	0.123963383115432	0.465042178330119	11:45240300-45286319:-	SYT13	15;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006906,biological_process vesicle fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030133,cellular_component transport vesicle;GO:0030276,molecular_function clathrin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0098793,cellular_component presynapse	NA	synaptotagmin 13 [Source:HGNC Symbol%3BAcc:HGNC:14962]
ENSG00000163602	30.66	27.26	28.90	33.42	29.89	33.54	-0.141768430568166	4.33455835232104	0.124017294928688	0.465042178330119	3:72371824-72446621:-	RYBP	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0031519,cellular_component PcG protein complex;GO:0035518,biological_process histone H2A monoubiquitination;GO:0046872,molecular_function metal ion binding	NA	RING1 and YY1 binding protein [Source:HGNC Symbol%3BAcc:HGNC:10480]
ENSG00000180801	13.20	13.77	13.30	14.78	13.16	17.13	-0.154266227720498	4.68749230334397	0.124050391279891	0.465042178330119	4:113900283-113979727:-	ARSJ	12;GO:0003824,molecular_function catalytic activity;GO:0004065,molecular_function arylsulfatase activity;GO:0005576,cellular_component extracellular region;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	arylsulfatase family member J [Source:HGNC Symbol%3BAcc:HGNC:26286]
ENSG00000155368	635.87	736.77	595.61	538.93	693.35	550.48	0.154243276708921	8.56665043080704	0.124060331117638	0.465042178330119	2:119366920-119372560:+	DBI	12;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0006637,biological_process acyl-CoA metabolic process;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0030156,molecular_function benzodiazepine receptor binding;GO:0036042,molecular_function long-chain fatty acyl-CoA binding;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0046983,molecular_function protein dimerization activity;GO:0070062,cellular_component extracellular exosome	DBI, ACBP; diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein); K08762	diazepam binding inhibitor%2C acyl-CoA binding protein [Source:HGNC Symbol%3BAcc:HGNC:2690]
ENSG00000111639	227.33	239.41	214.67	244.11	238.00	256.00	-0.105671590342746	6.50837200357879	0.124146686108648	0.465042178330119	12:6491885-6493841:-	MRPL51	12;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L51 [Source:HGNC Symbol%3BAcc:HGNC:14044]
ENSG00000147124	4.93	5.07	4.12	5.51	5.49	5.12	-0.1843952039366	3.60009748884339	0.124181394463117	0.465042178330119	X:47445878-47482946:-	ZNF41	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 41 [Source:HGNC Symbol%3BAcc:HGNC:13107]
ENSG00000167900	54.36	60.47	46.39	57.90	64.63	56.77	-0.14558171987522	5.55246756934877	0.124184722034145	0.465042178330119	17:78174074-78187233:-	TK1	21;GO:0000166,molecular_function nucleotide binding;GO:0004797,molecular_function thymidine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006259,biological_process DNA metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009157,biological_process deoxyribonucleoside monophosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0042802,molecular_function identical protein binding;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0046104,biological_process thymidine metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0071897,biological_process DNA biosynthetic process	tdk, TK; thymidine kinase [EC:2.7.1.21]; K00857	thymidine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:11830]
ENSG00000101311	3.16	2.82	2.50	3.28	3.10	3.70	-0.23715808872343	2.69296260186759	0.124187882469715	0.465042178330119	20:6074844-6123544:-	FERMT1	25;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0031941,cellular_component filamentous actin;GO:0032587,cellular_component ruffle membrane;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0042308,biological_process negative regulation of protein import into nucleus;GO:0042995,cellular_component cell projection;GO:0043616,biological_process keratinocyte proliferation;GO:0051546,biological_process keratinocyte migration;GO:0051886,biological_process negative regulation of anagen;GO:0071711,biological_process basement membrane organization;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090162,biological_process establishment of epithelial cell polarity;GO:2000647,biological_process negative regulation of stem cell proliferation;GO:2001203,biological_process positive regulation of transforming growth factor-beta secretion	NA	fermitin family member 1 [Source:HGNC Symbol%3BAcc:HGNC:15889]
ENSG00000150628	1.00	0.52	0.80	1.47	0.91	1.23	-0.578095430666938	0.105727554359915	0.124193572960956	0.465042178330119	4:176184637-176195671:-	SPATA4	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm	NA	spermatogenesis associated 4 [Source:HGNC Symbol%3BAcc:HGNC:17333]
ENSG00000175309	21.66	20.26	22.39	21.72	18.88	18.80	0.130052716110877	5.07606533695526	0.124380294965085	0.465434705855943	5:178208496-178232791:-	PHYKPL	12;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006554,biological_process lysine catabolic process;GO:0008453,molecular_function alanine-glyoxylate transaminase activity;GO:0008483,molecular_function transaminase activity;GO:0016740,molecular_function transferase activity;GO:0016829,molecular_function lyase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030574,biological_process collagen catabolic process;GO:0042802,molecular_function identical protein binding	AGXT2L1, ETNPPL; ethanolamine-phosphate phospho-lyase [EC:4.2.3.2]; K14286	5-phosphohydroxy-L-lysine phospho-lyase [Source:HGNC Symbol%3BAcc:HGNC:28249]
ENSG00000112146	50.25	51.62	49.94	53.12	53.26	57.49	-0.0998451973240536	6.32328041699474	0.124406984894479	0.465434705855943	6:53051990-53100873:+	FBXO9	13;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0032006,biological_process regulation of TOR signaling;GO:0043687,biological_process post-translational protein modification;GO:0045087,biological_process innate immune response;GO:0045444,biological_process fat cell differentiation	NA	F-box protein 9 [Source:HGNC Symbol%3BAcc:HGNC:13588]
ENSG00000183751	12.32	11.51	11.06	12.60	12.98	12.67	-0.119554603623554	4.90518695714695	0.124410888103603	0.465434705855943	16:1972036-1982933:+	TBL3	10;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030515,molecular_function snoRNA binding;GO:0032040,cellular_component small-subunit processome;GO:0034388,cellular_component Pwp2p-containing subcomplex of 90S preribosome	UTP13, TBL3; U3 small nucleolar RNA-associated protein 13; K14555	transducin beta like 3 [Source:HGNC Symbol%3BAcc:HGNC:11587]
ENSG00000163357	1.05	1.14	1.38	1.60	1.58	1.35	-0.323726708129287	1.73582840171471	0.124600565431772	0.466003862218917	1:155033823-155050930:+	DCST1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	DC-STAMP domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26539]
ENSG00000116990	1.14	0.95	0.90	1.55	1.69	1.02	-0.480974381222887	0.795059973357492	0.125028899450046	0.46732545862233	1:39895425-39902256:-	MYCL	6;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045607,biological_process regulation of auditory receptor cell differentiation;GO:0046983,molecular_function protein dimerization activity	NA	MYCL proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol%3BAcc:HGNC:7555]
ENSG00000204922	12.40	12.67	14.51	14.22	14.68	20.67	-0.314449749985383	2.11346756459672	0.125067564956426	0.46732545862233	11:62670272-62673687:+	UQCC3	13;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0006754,biological_process ATP biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly;GO:0042407,biological_process cristae formation;GO:0070300,molecular_function phosphatidic acid binding;GO:0097033,biological_process mitochondrial respiratory chain complex III biogenesis;GO:1901612,molecular_function cardiolipin binding	NA	ubiquinol-cytochrome c reductase complex assembly factor 3 [Source:HGNC Symbol%3BAcc:HGNC:34399]
ENSG00000174165	6.76	6.66	7.25	5.15	6.13	6.54	0.226452947793985	2.81886598624659	0.125100245802449	0.46732545862233	11:66520636-66546238:-	ZDHHC24	6;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 24 [Source:HGNC Symbol%3BAcc:HGNC:27387]
ENSG00000198924	7.42	7.26	6.44	7.58	7.39	8.54	-0.145930098872431	4.54826961301795	0.12510452743108	0.46732545862233	10:113834724-113854383:-	DCLRE1A	14;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001650,cellular_component fibrillar center;GO:0003684,molecular_function damaged DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0031848,biological_process protection from non-homologous end joining at telomere;GO:0035312,molecular_function 5'-3' exodeoxyribonuclease activity;GO:0036297,biological_process interstrand cross-link repair;GO:0051301,biological_process cell division;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	DNA cross-link repair 1A [Source:HGNC Symbol%3BAcc:HGNC:17660]
ENSG00000105329	143.84	115.89	137.12	122.41	110.46	132.38	0.132840144697878	7.28750095900996	0.125148611982555	0.46734949474713	19:41301586-41353911:-	TGFB1	229;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0001570,biological_process vasculogenesis;GO:0001657,biological_process ureteric bud development;GO:0001666,biological_process response to hypoxia;GO:0001763,biological_process morphogenesis of a branching structure;GO:0001775,biological_process cell activation;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001843,biological_process neural tube closure;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002028,biological_process regulation of sodium ion transport;GO:0002062,biological_process chondrocyte differentiation;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002248,biological_process connective tissue replacement involved in inflammatory response wound healing;GO:0002460,biological_process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;GO:0002513,biological_process tolerance induction to self antigen;GO:0002576,biological_process platelet degranulation;GO:0003179,biological_process heart valve morphogenesis;GO:0003823,molecular_function antigen binding;GO:0005114,molecular_function type II transforming growth factor beta receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006468,biological_process protein phosphorylation;GO:0006611,biological_process protein export from nucleus;GO:0006754,biological_process ATP biosynthetic process;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006954,biological_process inflammatory response;GO:0007050,biological_process cell cycle arrest;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007182,biological_process common-partner SMAD protein phosphorylation;GO:0007183,biological_process SMAD protein complex assembly;GO:0007184,biological_process SMAD protein import into nucleus;GO:0007219,biological_process Notch signaling pathway;GO:0007406,biological_process negative regulation of neuroblast proliferation;GO:0007435,biological_process salivary gland morphogenesis;GO:0007492,biological_process endoderm development;GO:0007507,biological_process heart development;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0008083,molecular_function growth factor activity;GO:0008156,biological_process negative regulation of DNA replication;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008354,biological_process germ cell migration;GO:0009314,biological_process response to radiation;GO:0009611,biological_process response to wounding;GO:0009749,biological_process response to glucose;GO:0009817,biological_process defense response to fungus, incompatible interaction;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0010468,biological_process regulation of gene expression;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010716,biological_process negative regulation of extracellular matrix disassembly;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010742,biological_process macrophage derived foam cell differentiation;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0010936,biological_process negative regulation of macrophage cytokine production;GO:0014003,biological_process oligodendrocyte development;GO:0014070,biological_process response to organic cyclic compound;GO:0016049,biological_process cell growth;GO:0016202,biological_process regulation of striated muscle tissue development;GO:0016477,biological_process cell migration;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0019049,biological_process evasion or tolerance of host defenses by virus;GO:0019899,molecular_function enzyme binding;GO:0021915,biological_process neural tube development;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030141,cellular_component secretory granule;GO:0030214,biological_process hyaluronan catabolic process;GO:0030217,biological_process T cell differentiation;GO:0030279,biological_process negative regulation of ossification;GO:0030308,biological_process negative regulation of cell growth;GO:0030334,biological_process regulation of cell migration;GO:0030335,biological_process positive regulation of cell migration;GO:0030424,cellular_component axon;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030879,biological_process mammary gland development;GO:0031012,cellular_component extracellular matrix;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031100,biological_process organ regeneration;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031536,biological_process positive regulation of exit from mitosis;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032355,biological_process response to estradiol;GO:0032570,biological_process response to progesterone;GO:0032667,biological_process regulation of interleukin-23 production;GO:0032700,biological_process negative regulation of interleukin-17 production;GO:0032740,biological_process positive regulation of interleukin-17 production;GO:0032801,biological_process receptor catabolic process;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0032943,biological_process mononuclear cell proliferation;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033280,biological_process response to vitamin D;GO:0034616,biological_process response to laminar fluid shear stress;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0034714,molecular_function type III transforming growth factor beta receptor binding;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0035902,biological_process response to immobilization stress;GO:0042060,biological_process wound healing;GO:0042110,biological_process T cell activation;GO:0042127,biological_process regulation of cell proliferation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042306,biological_process regulation of protein import into nucleus;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042482,biological_process positive regulation of odontogenesis;GO:0042493,biological_process response to drug;GO:0042552,biological_process myelination;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0043025,cellular_component neuronal cell body;GO:0043029,biological_process T cell homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043117,biological_process positive regulation of vascular permeability;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043491,biological_process protein kinase B signaling;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0043537,biological_process negative regulation of blood vessel endothelial cell migration;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0043932,biological_process ossification involved in bone remodeling;GO:0045066,biological_process regulatory T cell differentiation;GO:0045216,biological_process cell-cell junction organization;GO:0045589,biological_process regulation of regulatory T cell differentiation;GO:0045591,biological_process positive regulation of regulatory T cell differentiation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046732,biological_process active induction of host immune response by virus;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048298,biological_process positive regulation of isotype switching to IgA isotypes;GO:0048468,biological_process cell development;GO:0048535,biological_process lymph node development;GO:0048565,biological_process digestive tract development;GO:0048642,biological_process negative regulation of skeletal muscle tissue development;GO:0048839,biological_process inner ear development;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050714,biological_process positive regulation of protein secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050765,biological_process negative regulation of phagocytosis;GO:0050777,biological_process negative regulation of immune response;GO:0050868,biological_process negative regulation of T cell activation;GO:0050900,biological_process leukocyte migration;GO:0050921,biological_process positive regulation of chemotaxis;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051098,biological_process regulation of binding;GO:0051101,biological_process regulation of DNA binding;GO:0051152,biological_process positive regulation of smooth muscle cell differentiation;GO:0051280,biological_process negative regulation of release of sequestered calcium ion into cytosol;GO:0051781,biological_process positive regulation of cell division;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0060312,biological_process regulation of blood vessel remodeling;GO:0060325,biological_process face morphogenesis;GO:0060364,biological_process frontal suture morphogenesis;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060390,biological_process regulation of SMAD protein import into nucleus;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060395,biological_process SMAD protein signal transduction;GO:0060744,biological_process mammary gland branching involved in thelarche;GO:0060751,biological_process branch elongation involved in mammary gland duct branching;GO:0060762,biological_process regulation of branching involved in mammary gland duct morphogenesis;GO:0060965,biological_process negative regulation of gene silencing by miRNA;GO:0061035,biological_process regulation of cartilage development;GO:0070306,biological_process lens fiber cell differentiation;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070723,biological_process response to cholesterol;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071677,biological_process positive regulation of mononuclear cell migration;GO:0072562,cellular_component blood microparticle;GO:0085029,biological_process extracellular matrix assembly;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097421,biological_process liver regeneration;GO:1900126,biological_process negative regulation of hyaluronan biosynthetic process;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901203,biological_process positive regulation of extracellular matrix assembly;GO:1901666,biological_process positive regulation of NAD+ ADP-ribosyltransferase activity;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903077,biological_process negative regulation of protein localization to plasma membrane;GO:1903799,biological_process negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:1903800,biological_process positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1903911,biological_process positive regulation of receptor clustering;GO:1905313,biological_process transforming growth factor beta receptor signaling pathway involved in heart development;GO:1990314,biological_process cellular response to insulin-like growth factor stimulus;GO:1990402,biological_process embryonic liver development;GO:2000249,biological_process regulation of actin cytoskeleton reorganization;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding;GO:2000727,biological_process positive regulation of cardiac muscle cell differentiation	TGFB1; transforming growth factor beta-1; K13375	transforming growth factor beta 1 [Source:HGNC Symbol%3BAcc:HGNC:11766]
ENSG00000128694	13.42	9.77	12.44	13.44	13.25	14.10	-0.17052901731872	4.00721539189238	0.125321187355333	0.46782410415176	2:189746659-189763227:-	OSGEPL1	10;GO:0000408,cellular_component EKC/KEOPS complex;GO:0002949,biological_process tRNA threonylcarbamoyladenosine modification;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0006508,biological_process proteolysis;GO:0008033,biological_process tRNA processing;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0046872,molecular_function metal ion binding;GO:0061711,molecular_function N(6)-L-threonylcarbamoyladenine synthase	NA	O-sialoglycoprotein endopeptidase like 1 [Source:HGNC Symbol%3BAcc:HGNC:23075]
ENSG00000167380	11.92	13.29	12.75	11.32	11.80	12.01	0.119214311841679	4.92716253968147	0.125351081157557	0.46782410415176	19:44165072-44178381:+	ZNF226	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 226 [Source:HGNC Symbol%3BAcc:HGNC:13019]
ENSG00000142623	2.73	1.25	1.92	3.43	1.79	2.79	-0.409362305387003	2.27791658858878	0.125419004113906	0.467936909547917	1:17205125-17246005:+	PADI1	11;GO:0004668,molecular_function protein-arginine deiminase activity;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0016787,molecular_function hydrolase activity;GO:0018101,biological_process protein citrullination;GO:0036414,biological_process histone citrullination;GO:0070062,cellular_component extracellular exosome	NA	peptidyl arginine deiminase 1 [Source:HGNC Symbol%3BAcc:HGNC:18367]
ENSG00000137845	85.11	83.56	83.79	88.54	91.31	90.94	-0.0891706491944381	7.80679657154831	0.125483134473764	0.468035501268879	15:58588806-58749978:-	ADAM10	53;GO:0000139,cellular_component Golgi membrane;GO:0001701,biological_process in utero embryonic development;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010820,biological_process positive regulation of T cell chemotaxis;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019901,molecular_function protein kinase binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0034612,biological_process response to tumor necrosis factor;GO:0035579,cellular_component specific granule membrane;GO:0042117,biological_process monocyte activation;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051088,biological_process PMA-inducible membrane protein ectodomain proteolysis;GO:0051089,biological_process constitutive protein ectodomain proteolysis;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0097038,cellular_component perinuclear endoplasmic reticulum;GO:0097197,cellular_component tetraspanin-enriched microdomain	ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]; K06704	ADAM metallopeptidase domain 10 [Source:HGNC Symbol%3BAcc:HGNC:188]
ENSG00000159720	35.34	46.37	36.20	32.69	40.69	32.18	0.168166993127205	5.82353467647931	0.125637197700863	0.468469370700154	16:67438013-67481237:-	ATP6V0D1	36;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005769,cellular_component early endosome;GO:0005813,cellular_component centrosome;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007034,biological_process vacuolar transport;GO:0007035,biological_process vacuolar acidification;GO:0007420,biological_process brain development;GO:0008021,cellular_component synaptic vesicle;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008553,molecular_function hydrogen-exporting ATPase activity, phosphorylative mechanism;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016324,cellular_component apical plasma membrane;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0030030,biological_process cell projection organization;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0032403,molecular_function protein complex binding;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0036295,biological_process cellular response to increased oxygen levels;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043005,cellular_component neuron projection;GO:0043234,cellular_component protein complex;GO:0043679,cellular_component axon terminus;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	NA	ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol%3BAcc:HGNC:13724]
ENSG00000137601	6.71	6.68	7.45	7.39	7.37	8.27	-0.130276425463633	4.83025797942198	0.125750331056167	0.468716909448539	4:169392856-169612629:-	NEK1	29;GO:0000166,molecular_function nucleotide binding;GO:0000242,cellular_component pericentriolar material;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030030,biological_process cell projection organization;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0060271,biological_process cilium morphogenesis;GO:0071889,molecular_function 14-3-3 protein binding	NA	NIMA related kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:7744]
ENSG00000275004	2.34	2.11	2.17	2.62	2.75	2.72	-0.270437843783597	2.05825513765427	0.125779104597848	0.468716909448539	22:22484420-22509154:-	ZNF280B	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 280B [Source:HGNC Symbol%3BAcc:HGNC:23022]
ENSG00000160588	2.77	3.23	1.89	2.53	3.39	4.76	-0.445140772931748	1.28925864408938	0.125856422797044	0.468864278565338	11:118226689-118252350:-	MPZL3	6;GO:0005515,molecular_function protein binding;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0042633,biological_process hair cycle	NA	myelin protein zero like 3 [Source:HGNC Symbol%3BAcc:HGNC:27279]
ENSG00000116586	80.83	88.56	84.23	80.20	81.57	73.60	0.116975859963717	5.20102217207485	0.125900694334512	0.468888484480736	1:156054751-156058510:+	LAMTOR2	25;GO:0000165,biological_process MAPK cascade;GO:0000186,biological_process activation of MAPKK activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0007050,biological_process cell cycle arrest;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016241,biological_process regulation of macroautophagy;GO:0031902,cellular_component late endosome membrane;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032947,molecular_function protein complex scaffold;GO:0034613,biological_process cellular protein localization;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071986,cellular_component Ragulator complex	NA	late endosomal/lysosomal adaptor%2C MAPK and MTOR activator 2 [Source:HGNC Symbol%3BAcc:HGNC:29796]
ENSG00000124243	7.47	7.55	7.37	9.40	9.20	8.03	-0.237033572817805	2.57359501892645	0.126144143226864	0.469634315469551	20:50794893-50882676:+	BCAS4	3;GO:0005737,cellular_component cytoplasm;GO:0031083,cellular_component BLOC-1 complex;GO:0046907,biological_process intracellular transport	NA	breast carcinoma amplified sequence 4 [Source:HGNC Symbol%3BAcc:HGNC:14367]
ENSG00000161920	23.39	23.21	21.45	18.51	22.77	18.63	0.195466308322182	3.2912766370908	0.12619045925566	0.469634315469551	17:4731427-4733610:+	MED11	10;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	mediator complex subunit 11 [Source:HGNC Symbol%3BAcc:HGNC:32687]
ENSG00000186026	2.94	2.52	3.23	2.53	2.30	2.49	0.270672087070636	2.29660699155306	0.126251035763348	0.469634315469551	19:44072143-44089613:+	ZNF284	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 284 [Source:HGNC Symbol%3BAcc:HGNC:13078]
ENSG00000162620	2.26	1.70	2.21	2.69	2.43	2.43	-0.259541205561712	2.27275473707556	0.12630404250981	0.469634315469551	1:74026014-74198187:-	LRRIQ3	1;GO:0005515,molecular_function protein binding	NA	leucine rich repeats and IQ motif containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28318]
ENSG00000149541	23.12	20.22	24.60	21.14	19.39	21.68	0.144564215258247	4.66289842315184	0.126312285811619	0.469634315469551	11:62615295-62622175:-	B3GAT3	22;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005975,biological_process carbohydrate metabolic process;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006486,biological_process protein glycosylation;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0015018,molecular_function galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030204,biological_process chondroitin sulfate metabolic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046872,molecular_function metal ion binding;GO:0050650,biological_process chondroitin sulfate proteoglycan biosynthetic process;GO:0050651,biological_process dermatan sulfate proteoglycan biosynthetic process;GO:0070062,cellular_component extracellular exosome;GO:0072542,molecular_function protein phosphatase activator activity;GO:0090316,biological_process positive regulation of intracellular protein transport	B3GAT3; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [EC:2.4.1.135]; K10158	beta-1%2C3-glucuronyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:923]
ENSG00000007255	65.45	72.73	74.74	61.17	71.17	63.81	0.1286727316646	5.15006953338427	0.126363333493777	0.469634315469551	19:45162927-45178237:-	TRAPPC6A	17;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043473,biological_process pigmentation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization;GO:1903232,biological_process melanosome assembly	NA	trafficking protein particle complex 6A [Source:HGNC Symbol%3BAcc:HGNC:23069]
ENSG00000070882	12.98	11.37	12.18	14.86	12.15	13.44	-0.132093339156282	5.19733870326355	0.126400676548789	0.469634315469551	7:24796538-24981634:-	OSBPL3	19;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006699,biological_process bile acid biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0015248,molecular_function sterol transporter activity;GO:0015485,molecular_function cholesterol binding;GO:0015918,biological_process sterol transport;GO:0016020,cellular_component membrane;GO:0031965,cellular_component nuclear membrane;GO:0032433,cellular_component filopodium tip;GO:0042995,cellular_component cell projection;GO:0097038,cellular_component perinuclear endoplasmic reticulum	NA	oxysterol binding protein like 3 [Source:HGNC Symbol%3BAcc:HGNC:16370]
ENSG00000172123	8.80	7.94	8.02	8.29	9.53	10.22	-0.165858157879137	3.95085988980242	0.126422261020143	0.469634315469551	17:35411059-35433283:-	SLFN12	1;GO:0005524,molecular_function ATP binding	NA	schlafen family member 12 [Source:HGNC Symbol%3BAcc:HGNC:25500]
ENSG00000140876	1.89	2.25	1.34	1.36	1.38	1.20	0.462070010590381	0.675688194427081	0.126441463167585	0.469634315469551	16:77722491-77742260:+	NUDT7	19;GO:0000287,molecular_function magnesium ion binding;GO:0003674,molecular_function molecular_function;GO:0003723,molecular_function RNA binding;GO:0003986,molecular_function acetyl-CoA hydrolase activity;GO:0005102,molecular_function receptor binding;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0008150,biological_process biological_process;GO:0009062,biological_process fatty acid catabolic process;GO:0009132,biological_process nucleoside diphosphate metabolic process;GO:0015938,biological_process coenzyme A catabolic process;GO:0016289,molecular_function CoA hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0030145,molecular_function manganese ion binding;GO:0030515,molecular_function snoRNA binding;GO:0046356,biological_process acetyl-CoA catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050873,biological_process brown fat cell differentiation	NA	nudix hydrolase 7 [Source:HGNC Symbol%3BAcc:HGNC:8054]
ENSG00000204568	87.51	80.50	82.92	90.45	86.52	94.76	-0.101601993087549	6.08054188242711	0.126532015261295	0.469799131194248	6:30617708-30626395:+	MRPS18B	13;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030054,cellular_component cell junction;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	MRPS18B, MRPS18-2; small subunit ribosomal protein S18b, mitochondrial; K16174	mitochondrial ribosomal protein S18B [Source:HGNC Symbol%3BAcc:HGNC:14516]
ENSG00000158163	6.57	6.36	7.11	5.16	6.63	6.17	0.172273895113419	3.99655808841639	0.126561531838683	0.469799131194248	3:138061989-138115818:-	DZIP1L	11;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0032880,biological_process regulation of protein localization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis	NA	DAZ interacting zinc finger protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:26551]
ENSG00000107186	8.56	7.75	8.57	7.27	8.20	7.75	0.114241559883322	5.66760209489054	0.126677322984658	0.469971441720247	9:13105703-13279590:-	MPDZ	19;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007155,biological_process cell adhesion;GO:0008022,molecular_function protein C-terminus binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016324,cellular_component apical plasma membrane;GO:0016327,cellular_component apicolateral plasma membrane;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043220,cellular_component Schmidt-Lanterman incisure;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	MPDZ, MUPP1, Patj; multiple PDZ domain protein; K06095	multiple PDZ domain crumbs cell polarity complex component [Source:HGNC Symbol%3BAcc:HGNC:7208]
ENSG00000061938	7.38	6.65	7.16	6.40	6.77	6.47	0.125763117242927	4.78009114507724	0.12668367388995	0.469971441720247	3:195863363-195911945:-	TNK2	44;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005912,cellular_component adherens junction;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030054,cellular_component cell junction;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030154,biological_process cell differentiation;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034260,biological_process negative regulation of GTPase activity;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050699,molecular_function WW domain binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0070436,cellular_component Grb2-EGFR complex;GO:2000369,biological_process regulation of clathrin-mediated endocytosis	NA	tyrosine kinase non receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:19297]
ENSG00000120800	5.65	6.17	5.98	6.49	6.26	6.51	-0.105338438561921	5.69388178009676	0.126763309782489	0.470126371177183	12:101280108-101386616:+	UTP20	16;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472,biological_process endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480,biological_process endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006364,biological_process rRNA processing;GO:0008285,biological_process negative regulation of cell proliferation;GO:0030686,cellular_component 90S preribosome;GO:0030688,cellular_component preribosome, small subunit precursor;GO:0032040,cellular_component small-subunit processome	NA	UTP20%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:17897]
ENSG00000137500	45.78	48.58	46.94	56.43	45.52	53.51	-0.128050082065979	5.57199307598265	0.126956344008869	0.47042831937988	11:83259096-83286407:-	CCDC90B	5;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane	NA	coiled-coil domain containing 90B [Source:HGNC Symbol%3BAcc:HGNC:28108]
ENSG00000068097	10.22	10.59	10.33	11.18	10.67	12.06	-0.113509766151046	5.32909431008675	0.126964360680764	0.47042831937988	17:60043193-60078931:-	HEATR6	1;GO:0003723,molecular_function RNA binding	NA	HEAT repeat containing 6 [Source:HGNC Symbol%3BAcc:HGNC:24076]
ENSG00000129474	89.08	89.60	85.27	93.82	96.01	93.89	-0.092845346289663	7.29267831485891	0.126985593283668	0.47042831937988	14:22971173-22982642:-	AJUBA	48;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001666,biological_process response to hypoxia;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030054,cellular_component cell junction;GO:0030334,biological_process regulation of cell migration;GO:0031047,biological_process gene silencing by RNA;GO:0031328,biological_process positive regulation of cellular biosynthetic process;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0033673,biological_process negative regulation of kinase activity;GO:0033674,biological_process positive regulation of kinase activity;GO:0034613,biological_process cellular protein localization;GO:0035195,biological_process gene silencing by miRNA;GO:0035313,biological_process wound healing, spreading of epidermal cells;GO:0035331,biological_process negative regulation of hippo signaling;GO:0043087,biological_process regulation of GTPase activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0045294,molecular_function alpha-catenin binding;GO:0046474,biological_process glycerophospholipid biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0048041,biological_process focal adhesion assembly;GO:0051015,molecular_function actin filament binding;GO:1900037,biological_process regulation of cellular response to hypoxia;GO:2000637,biological_process positive regulation of gene silencing by miRNA	AJUBA, LIMD1, WTIP; LIM domain-containing protein; K16682	ajuba LIM protein [Source:HGNC Symbol%3BAcc:HGNC:20250]
ENSG00000138399	11.37	12.94	11.47	12.96	13.04	13.14	-0.124937195858693	4.99408730980558	0.126996318234269	0.47042831937988	2:169529748-169573875:-	FASTKD1	5;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0005739,cellular_component mitochondrion;GO:0006468,biological_process protein phosphorylation;GO:0045333,biological_process cellular respiration	NA	FAST kinase domains 1 [Source:HGNC Symbol%3BAcc:HGNC:26150]
ENSG00000115963	57.70	53.79	60.13	51.45	50.87	57.35	0.118099795051027	5.3443671239229	0.127144586558968	0.470837038471502	2:150468194-150539011:-	RND3	13;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0070062,cellular_component extracellular exosome	NA	Rho family GTPase 3 [Source:HGNC Symbol%3BAcc:HGNC:671]
ENSG00000100815	13.28	14.25	15.01	13.35	13.47	13.09	0.103353580877804	6.35804896674975	0.127275566491568	0.471021996284518	14:91965990-92040896:-	TRIP11	25;GO:0000042,biological_process protein targeting to Golgi;GO:0000139,cellular_component Golgi membrane;GO:0002079,cellular_component inner acrosomal membrane;GO:0002080,cellular_component acrosomal membrane;GO:0002081,cellular_component outer acrosomal membrane;GO:0003281,biological_process ventricular septum development;GO:0003413,biological_process chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006486,biological_process protein glycosylation;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030133,cellular_component transport vesicle;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0060348,biological_process bone development;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	thyroid hormone receptor interactor 11 [Source:HGNC Symbol%3BAcc:HGNC:12305]
ENSG00000119801	144.75	150.85	167.48	172.02	168.19	163.88	-0.109858182236582	5.87599721112276	0.127291098495437	0.471021996284518	2:30146940-30160533:+	YPEL5	5;GO:0005576,cellular_component extracellular region;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	yippee like 5 [Source:HGNC Symbol%3BAcc:HGNC:18329]
ENSG00000110074	23.29	26.17	22.85	22.00	23.60	21.13	0.12322494595354	5.12377329926641	0.127308370058371	0.471021996284518	11:126269054-126278131:+	FOXRED1	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NA	FAD dependent oxidoreductase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26927]
ENSG00000007402	0.59	0.25	0.38	0.35	0.26	0.24	0.570175304464288	0.451267889165675	0.127390693636195	0.471186138291445	3:50362798-50504244:-	CACNA2D2	20;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007528,biological_process neuromuscular junction development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0040014,biological_process regulation of multicellular organism growth;GO:0046622,biological_process positive regulation of organ growth;GO:0046872,molecular_function metal ion binding;GO:0048747,biological_process muscle fiber development;GO:0050796,biological_process regulation of insulin secretion;GO:0060024,biological_process rhythmic synaptic transmission;GO:0061337,biological_process cardiac conduction;GO:0070588,biological_process calcium ion transmembrane transport	CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2; K04859	calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol%3BAcc:HGNC:1400]
ENSG00000126088	74.15	76.82	77.95	69.09	71.16	75.24	0.0981841435233721	6.3528212879765	0.127585890466038	0.471542857396296	1:45012146-45015575:+	UROD	11;GO:0004853,molecular_function uroporphyrinogen decarboxylase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0042168,biological_process heme metabolic process	hemE, UROD; uroporphyrinogen decarboxylase [EC:4.1.1.37]; K01599	uroporphyrinogen decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:12591]
ENSG00000155428	2.73	1.66	2.36	1.90	1.31	1.69	0.495953857529219	0.696590720281054	0.127615515686337	0.471542857396296	7:72959484-72969466:-	TRIM74	4;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 74 [Source:HGNC Symbol%3BAcc:HGNC:17453]
ENSG00000204351	23.00	22.53	22.39	21.01	21.74	21.37	0.0950413061546071	6.37808164811671	0.127658662118023	0.471542857396296	6:31959079-31969755:+	SKIV2L	15;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006401,biological_process RNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0055087,cellular_component Ski complex;GO:0070478,biological_process nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	SKI2, SKIV2L; antiviral helicase SKI2 [EC:3.6.4.-]; K12599	Ski2 like RNA helicase [Source:HGNC Symbol%3BAcc:HGNC:10898]
ENSG00000143499	43.71	43.09	45.94	48.80	46.01	48.64	-0.0991633627590827	5.91299988656541	0.127666608577719	0.471542857396296	1:214281101-214337131:+	SMYD2	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000993,molecular_function RNA polymerase II core binding;GO:0002039,molecular_function p53 binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007507,biological_process heart development;GO:0008168,molecular_function methyltransferase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010452,biological_process histone H3-K36 methylation;GO:0016278,molecular_function lysine N-methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0018027,biological_process peptidyl-lysine dimethylation;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0043516,biological_process regulation of DNA damage response, signal transduction by p53 class mediator;GO:0046872,molecular_function metal ion binding;GO:0046975,molecular_function histone methyltransferase activity (H3-K36 specific);GO:1901796,biological_process regulation of signal transduction by p53 class mediator	SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357]; K11426	SET and MYND domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20982]
ENSG00000139209	0.51	0.64	0.95	0.38	0.58	0.47	0.551976074926468	0.370014478256047	0.127677075945295	0.471542857396296	12:46764760-46832408:-	SLC38A4	11;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 38 member 4 [Source:HGNC Symbol%3BAcc:HGNC:14679]
ENSG00000196456	2.63	2.73	1.96	1.63	2.26	1.96	0.326323000568756	1.8734991710948	0.12771535513133	0.471543933148483	7:150379334-150398631:+	ZNF775	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 775 [Source:HGNC Symbol%3BAcc:HGNC:28501]
ENSG00000114779	54.92	46.58	48.45	43.55	47.26	48.14	0.125549391325414	5.26839963406685	0.127783861245675	0.471656577354314	3:51968509-51983409:-	ABHD14B	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016787,molecular_function hydrolase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0070062,cellular_component extracellular exosome	NA	abhydrolase domain containing 14B [Source:HGNC Symbol%3BAcc:HGNC:28235]
ENSG00000173402	28.89	33.33	31.83	29.06	31.13	27.24	0.115064145524936	6.34665928823376	0.127894460978007	0.47192447803805	3:49468702-49535618:+	DAG1	84;GO:0001618,molecular_function virus receptor activity;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0002162,molecular_function dystroglycan binding;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006493,biological_process protein O-linked glycosylation;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007568,biological_process aging;GO:0008307,molecular_function structural constituent of muscle;GO:0009897,cellular_component external side of plasma membrane;GO:0010470,biological_process regulation of gastrulation;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0014037,biological_process Schwann cell differentiation;GO:0014044,biological_process Schwann cell development;GO:0014894,biological_process response to denervation involved in regulation of muscle adaptation;GO:0015631,molecular_function tubulin binding;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016011,cellular_component dystroglycan complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0016340,biological_process calcium-dependent cell-matrix adhesion;GO:0016476,biological_process regulation of embryonic cell shape;GO:0017166,molecular_function vinculin binding;GO:0019048,biological_process modulation by virus of host morphology or physiology;GO:0021675,biological_process nerve development;GO:0021682,biological_process nerve maturation;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030198,biological_process extracellular matrix organization;GO:0030336,biological_process negative regulation of cell migration;GO:0031103,biological_process axon regeneration;GO:0031643,biological_process positive regulation of myelination;GO:0033268,cellular_component node of Ranvier;GO:0034399,cellular_component nuclear periphery;GO:0034453,biological_process microtubule anchoring;GO:0042169,molecular_function SH2 domain binding;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0043236,molecular_function laminin binding;GO:0043237,molecular_function laminin-1 binding;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0043434,biological_process response to peptide hormone;GO:0044853,cellular_component plasma membrane raft;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046718,biological_process viral entry into host cell;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0051393,molecular_function alpha-actinin binding;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060445,biological_process branching involved in salivary gland morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070938,cellular_component contractile ring;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071397,biological_process cellular response to cholesterol;GO:0071679,biological_process commissural neuron axon guidance;GO:0071711,biological_process basement membrane organization;GO:1904261,biological_process positive regulation of basement membrane assembly involved in embryonic body morphogenesis	DAG1; dystroglycan 1; K06265	dystroglycan 1 [Source:HGNC Symbol%3BAcc:HGNC:2666]
ENSG00000185262	25.84	25.25	32.01	34.39	29.44	31.30	-0.17804762717223	3.88975873894125	0.127981169801896	0.472104089376205	17:76265201-76271299:+	UBALD2	NA	NA	UBA like domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28438]
ENSG00000136710	23.21	21.67	25.22	21.56	21.45	21.05	0.147846808449482	4.14802230389765	0.128049609038829	0.472216220142301	2:130338240-130342349:-	CCDC115	14;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007042,biological_process lysosomal lumen acidification;GO:0016020,cellular_component membrane;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0030137,cellular_component COPI-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0036295,biological_process cellular response to increased oxygen levels;GO:0042406,cellular_component extrinsic component of endoplasmic reticulum membrane;GO:0051082,molecular_function unfolded protein binding;GO:1905146,biological_process lysosomal protein catabolic process	NA	coiled-coil domain containing 115 [Source:HGNC Symbol%3BAcc:HGNC:28178]
ENSG00000133704	16.77	17.97	17.45	18.49	19.36	18.48	-0.10010757810319	5.97444594995747	0.128172623443104	0.472529484644861	12:30628987-30695986:-	IPO8	15;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0060964,biological_process regulation of gene silencing by miRNA	NA	importin 8 [Source:HGNC Symbol%3BAcc:HGNC:9853]
ENSG00000137076	79.59	79.95	75.06	73.32	75.66	73.26	0.0896744224961652	9.18233880990745	0.128311561813342	0.47290125201574	9:35696947-35732395:-	TLN1	38;GO:0001726,cellular_component ruffle;GO:0001786,molecular_function phosphatidylserine binding;GO:0002576,biological_process platelet degranulation;GO:0003779,molecular_function actin binding;GO:0005178,molecular_function integrin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0006936,biological_process muscle contraction;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007043,biological_process cell-cell junction assembly;GO:0007044,biological_process cell-substrate junction assembly;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0017166,molecular_function vinculin binding;GO:0030054,cellular_component cell junction;GO:0030274,molecular_function LIM domain binding;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0032403,molecular_function protein complex binding;GO:0032587,cellular_component ruffle membrane;GO:0033622,biological_process integrin activation;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation	TLN; talin; K06271	talin 1 [Source:HGNC Symbol%3BAcc:HGNC:11845]
ENSG00000197136	7.69	7.63	7.94	6.97	7.66	7.16	0.106911438405749	5.52247702237103	0.128373574785254	0.472989368895625	11:65615772-65637439:+	PCNX3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	pecanex homolog 3 [Source:HGNC Symbol%3BAcc:HGNC:18760]
ENSG00000164073	11.60	10.80	12.52	13.36	12.00	13.60	-0.141862081688257	4.38680141801034	0.128440912809219	0.473097047685707	4:127917731-127966034:-	MFSD8	11;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0007040,biological_process lysosome organization;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048666,biological_process neuron development;GO:0055085,biological_process transmembrane transport	MSFD8, CLN7; MFS transporter, ceroid-lipofuscinosis neuronal protein 7; K12307	major facilitator superfamily domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:28486]
ENSG00000174136	5.71	4.66	5.03	4.65	4.92	3.63	0.247204000569652	2.8059529474489	0.128527881319846	0.47327694773754	5:98768649-98798643:+	RGMB	12;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0030509,biological_process BMP signaling pathway;GO:0031225,cellular_component anchored component of membrane;GO:0042802,molecular_function identical protein binding;GO:0045121,cellular_component membrane raft;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046658,cellular_component anchored component of plasma membrane	RGMB; RGM domain family member B; K06847	repulsive guidance molecule family member b [Source:HGNC Symbol%3BAcc:HGNC:26896]
ENSG00000250799	1.75	2.96	2.24	2.60	3.01	2.96	-0.317901768264979	2.10380566433406	0.128644325889829	0.473565248300843	19:35799987-35813299:-	PRODH2	11;GO:0004657,molecular_function proline dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006560,biological_process proline metabolic process;GO:0006562,biological_process proline catabolic process;GO:0010133,biological_process proline catabolic process to glutamate;GO:0016491,molecular_function oxidoreductase activity;GO:0016645,molecular_function oxidoreductase activity, acting on the CH-NH group of donors;GO:0046487,biological_process glyoxylate metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	PRODH2; hydroxyproline dehydrogenase [EC:1.5.5.3]; K11394	proline dehydrogenase 2 [Source:HGNC Symbol%3BAcc:HGNC:17325]
ENSG00000100478	8.23	7.51	6.68	8.42	9.04	9.15	-0.234518088532461	2.63291931323185	0.128860553328137	0.474122570766265	14:31025105-31096450:+	AP4S1	9;GO:0005215,molecular_function transporter activity;GO:0005794,cellular_component Golgi apparatus;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0031904,cellular_component endosome lumen;GO:0032588,cellular_component trans-Golgi network membrane	AP4S1; AP-4 complex subunit sigma-1; K12403	adaptor related protein complex 4 sigma 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:575]
ENSG00000172819	13.27	11.26	12.38	11.63	10.43	11.61	0.150399395608642	4.27491609281702	0.128872114216175	0.474122570766265	12:53210566-53232980:-	RARG	62;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001843,biological_process neural tube closure;GO:0002063,biological_process chondrocyte development;GO:0002068,biological_process glandular epithelial cell development;GO:0003406,biological_process retinal pigment epithelium development;GO:0003417,biological_process growth plate cartilage development;GO:0003430,biological_process growth plate cartilage chondrocyte growth;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003708,molecular_function retinoic acid receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008361,biological_process regulation of cell size;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0016021,cellular_component integral component of membrane;GO:0031076,biological_process embryonic camera-type eye development;GO:0031641,biological_process regulation of myelination;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0032526,biological_process response to retinoic acid;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035264,biological_process multicellular organism growth;GO:0043010,biological_process camera-type eye development;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043068,biological_process positive regulation of programmed cell death;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0048048,biological_process embryonic eye morphogenesis;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0048608,biological_process reproductive structure development;GO:0048732,biological_process gland development;GO:0060041,biological_process retina development in camera-type eye;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060173,biological_process limb development;GO:0060324,biological_process face development;GO:0060348,biological_process bone development;GO:0060349,biological_process bone morphogenesis;GO:0060429,biological_process epithelium development;GO:0060534,biological_process trachea cartilage development;GO:0060740,biological_process prostate gland epithelium morphogenesis;GO:0061037,biological_process negative regulation of cartilage development;GO:0070384,biological_process Harderian gland development;GO:0071300,biological_process cellular response to retinoic acid;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	retinoic acid receptor gamma [Source:HGNC Symbol%3BAcc:HGNC:9866]
ENSG00000086065	141.36	141.97	143.95	148.60	164.50	149.31	-0.101934782201645	6.60947626727815	0.128945578136751	0.474252284862663	9:33264878-33282069:+	CHMP5	26;GO:0000920,biological_process cell separation after cytokinesis;GO:0001919,biological_process regulation of receptor recycling;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007040,biological_process lysosome organization;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008333,biological_process endosome to lysosome transport;GO:0010008,cellular_component endosome membrane;GO:0010824,biological_process regulation of centrosome duplication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0019058,biological_process viral life cycle;GO:0036258,biological_process multivesicular body assembly;GO:0045296,molecular_function cadherin binding;GO:0046755,biological_process viral budding;GO:0070062,cellular_component extracellular exosome;GO:0071985,biological_process multivesicular body sorting pathway;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1904903,biological_process ESCRT III complex disassembly	CHMP5, VPS60; charged multivesicular body protein 5; K12198	charged multivesicular body protein 5 [Source:HGNC Symbol%3BAcc:HGNC:26942]
ENSG00000142303	1.03	0.76	0.70	0.62	0.65	0.69	0.363617374423645	1.41121092709544	0.129048499526062	0.474400061861581	19:8580241-8610735:-	ADAMTS10	14;GO:0001527,cellular_component microfibril;GO:0003674,molecular_function molecular_function;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0008150,biological_process biological_process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0031012,cellular_component extracellular matrix;GO:0046872,molecular_function metal ion binding	NA	ADAM metallopeptidase with thrombospondin type 1 motif 10 [Source:HGNC Symbol%3BAcc:HGNC:13201]
ENSG00000170540	125.83	133.54	121.82	140.15	148.57	126.78	-0.113835327049425	6.34039716529698	0.12906219357984	0.474400061861581	16:18791666-18801678:-	ARL6IP1	18;GO:0002038,biological_process positive regulation of L-glutamate transport;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005784,cellular_component Sec61 translocon complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0006915,biological_process apoptotic process;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0071787,biological_process endoplasmic reticulum tubular network assembly;GO:1990809,biological_process endoplasmic reticulum tubular network membrane organization	NA	ADP ribosylation factor like GTPase 6 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:697]
ENSG00000185085	6.86	7.60	7.97	6.56	7.15	6.81	0.138142258781976	4.46011025619938	0.129229854986993	0.474852534944903	11:62646847-62653302:-	INTS5	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016180,biological_process snRNA processing;GO:0031965,cellular_component nuclear membrane;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:29352]
ENSG00000149792	72.20	78.78	71.08	65.18	73.25	68.33	0.111591802673063	5.5890549020478	0.129261799369921	0.474852534944903	11:65122182-65127371:+	MRPL49	12;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L49 [Source:HGNC Symbol%3BAcc:HGNC:1176]
ENSG00000196323	18.04	16.50	15.92	13.61	17.60	14.71	0.149577549771698	4.99058386301386	0.129345355995499	0.475018906500629	11:130226676-130314686:-	ZBTB44	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 44 [Source:HGNC Symbol%3BAcc:HGNC:25001]
ENSG00000133961	55.73	54.41	55.74	55.97	61.12	62.04	-0.098766007782774	6.81448223724289	0.129404278636809	0.475026506757964	14:73275106-73463642:-	NUMB	29;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007405,biological_process neuroblast proliferation;GO:0007409,biological_process axonogenesis;GO:0008013,molecular_function beta-catenin binding;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0021670,biological_process lateral ventricle development;GO:0021849,biological_process neuroblast division in subventricular zone;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030335,biological_process positive regulation of cell migration;GO:0030862,biological_process positive regulation of polarized epithelial cell differentiation;GO:0030900,biological_process forebrain development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034332,biological_process adherens junction organization;GO:0045177,cellular_component apical part of cell;GO:0045294,molecular_function alpha-catenin binding;GO:0045296,molecular_function cadherin binding;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0050769,biological_process positive regulation of neurogenesis;GO:0060487,biological_process lung epithelial cell differentiation;GO:1903077,biological_process negative regulation of protein localization to plasma membrane	NUMBL; numb; K06057	NUMB%2C endocytic adaptor protein [Source:HGNC Symbol%3BAcc:HGNC:8060]
ENSG00000177283	5.36	3.40	5.20	4.53	3.02	4.05	0.288306518732574	3.18554785362187	0.129423962447066	0.475026506757964	10:35638248-35642278:-	FZD8	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001525,biological_process angiogenesis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0030165,molecular_function PDZ domain binding;GO:0030182,biological_process neuron differentiation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033077,biological_process T cell differentiation in thymus;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060070,biological_process canonical Wnt signaling pathway;GO:1990851,cellular_component Wnt-Frizzled-LRP5/6 complex	FZD5_8, fz2; frizzled 5/8; K02375	frizzled class receptor 8 [Source:HGNC Symbol%3BAcc:HGNC:4046]
ENSG00000112200	11.21	9.84	10.74	9.50	9.80	10.42	0.1123066954877	5.62710835365163	0.129597679690175	0.47549971983182	6:57086843-57170307:+	ZNF451	17;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016605,cellular_component PML body;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0060633,biological_process negative regulation of transcription initiation from RNA polymerase II promoter;GO:0061665,molecular_function SUMO ligase activity;GO:2000616,biological_process negative regulation of histone H3-K9 acetylation	NA	zinc finger protein 451 [Source:HGNC Symbol%3BAcc:HGNC:21091]
ENSG00000132589	89.98	94.11	87.37	80.14	85.89	89.10	0.100130750181287	6.99271903832752	0.129629505511229	0.47549971983182	17:28879334-28897679:-	FLOT2	33;GO:0001765,biological_process membrane raft assembly;GO:0001931,cellular_component uropod;GO:0002020,molecular_function protease binding;GO:0002080,cellular_component acrosomal membrane;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0008544,biological_process epidermis development;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016600,cellular_component flotillin complex;GO:0030027,cellular_component lamellipodium;GO:0030139,cellular_component endocytic vesicle;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0044291,cellular_component cell-cell contact zone;GO:0044860,biological_process protein localization to plasma membrane raft;GO:0045121,cellular_component membrane raft;GO:0045661,biological_process regulation of myoblast differentiation;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:1902992,biological_process negative regulation of amyloid precursor protein catabolic process;GO:1903905,biological_process positive regulation of establishment of T cell polarity	FLOT; flotillin; K07192	flotillin 2 [Source:HGNC Symbol%3BAcc:HGNC:3758]
ENSG00000169083	0.30	0.47	0.17	0.75	0.22	0.46	-0.644297240975325	0.439139997069978	0.129675569758983	0.475528167627253	X:67544031-67730619:+	AR	97;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001701,biological_process in utero embryonic development;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0003382,biological_process epithelial cell morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004882,molecular_function androgen receptor activity;GO:0005102,molecular_function receptor binding;GO:0005496,molecular_function steroid binding;GO:0005497,molecular_function androgen binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0007548,biological_process sex differentiation;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008584,biological_process male gonad development;GO:0009566,biological_process fertilization;GO:0009987,biological_process cellular process;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0016049,biological_process cell growth;GO:0016579,biological_process protein deubiquitination;GO:0016607,cellular_component nuclear speck;GO:0019102,biological_process male somatic sex determination;GO:0019899,molecular_function enzyme binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0030850,biological_process prostate gland development;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0033327,biological_process Leydig cell differentiation;GO:0035264,biological_process multicellular organism growth;GO:0042327,biological_process positive regulation of phosphorylation;GO:0043234,cellular_component protein complex;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043568,biological_process positive regulation of insulin-like growth factor receptor signaling pathway;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045720,biological_process negative regulation of integrin biosynthetic process;GO:0045726,biological_process positive regulation of integrin biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0048608,biological_process reproductive structure development;GO:0048638,biological_process regulation of developmental growth;GO:0048645,biological_process organ formation;GO:0048808,biological_process male genitalia morphogenesis;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050790,biological_process regulation of catalytic activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051117,molecular_function ATPase binding;GO:0051259,biological_process protein oligomerization;GO:0060520,biological_process activation of prostate induction by androgen receptor signaling pathway;GO:0060571,biological_process morphogenesis of an epithelial fold;GO:0060599,biological_process lateral sprouting involved in mammary gland duct morphogenesis;GO:0060685,biological_process regulation of prostatic bud formation;GO:0060736,biological_process prostate gland growth;GO:0060740,biological_process prostate gland epithelium morphogenesis;GO:0060742,biological_process epithelial cell differentiation involved in prostate gland development;GO:0060748,biological_process tertiary branching involved in mammary gland duct morphogenesis;GO:0060749,biological_process mammary gland alveolus development;GO:0060769,biological_process positive regulation of epithelial cell proliferation involved in prostate gland development;GO:0061458,biological_process reproductive system development;GO:0070974,molecular_function POU domain binding;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0071394,biological_process cellular response to testosterone stimulus;GO:0072520,biological_process seminiferous tubule development;GO:0090003,biological_process regulation of establishment of protein localization to plasma membrane;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	AR, NR3C4; androgen receptor; K08557	androgen receptor [Source:HGNC Symbol%3BAcc:HGNC:644]
ENSG00000101391	12.14	13.14	12.98	13.99	14.60	13.53	-0.129058518936755	4.60389819666501	0.129830173105986	0.47583681908985	20:33358838-33401561:-	CDK5RAP1	20;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0003824,molecular_function catalytic activity;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006400,biological_process tRNA modification;GO:0007420,biological_process brain development;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0032403,molecular_function protein complex binding;GO:0035597,molecular_function N6-isopentenyladenosine methylthiotransferase activity;GO:0035600,biological_process tRNA methylthiolation;GO:0045664,biological_process regulation of neuron differentiation;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045903,biological_process positive regulation of translational fidelity;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0070131,biological_process positive regulation of mitochondrial translation;GO:0070900,biological_process mitochondrial tRNA modification	NA	CDK5 regulatory subunit associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15880]
ENSG00000100401	49.49	45.48	43.38	50.08	52.59	47.76	-0.108012444050532	6.40920538431857	0.129868543811341	0.47583681908985	22:41245610-41286251:-	RANGAP1	35;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0003723,molecular_function RNA binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007062,biological_process sister chromatid cohesion;GO:0007165,biological_process signal transduction;GO:0008536,molecular_function Ran GTPase binding;GO:0016020,cellular_component membrane;GO:0016235,cellular_component aggresome;GO:0016925,biological_process protein sumoylation;GO:0030425,cellular_component dendrite;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031965,cellular_component nuclear membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044614,cellular_component nuclear pore cytoplasmic filaments;GO:0045296,molecular_function cadherin binding;GO:0046826,biological_process negative regulation of protein export from nucleus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048678,biological_process response to axon injury;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0072686,cellular_component mitotic spindle;GO:1904115,cellular_component axon cytoplasm;GO:1904117,biological_process cellular response to vasopressin;GO:1990723,cellular_component cytoplasmic periphery of the nuclear pore complex	RANGAP1; Ran GTPase-activating protein 1; K14319	Ran GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9854]
ENSG00000188486	78.20	90.66	68.28	81.15	89.10	94.41	-0.153210651838619	5.16972597253888	0.129874739633965	0.47583681908985	11:119093853-119095467:-	H2AFX	32;GO:0000077,biological_process DNA damage checkpoint;GO:0000781,cellular_component chromosome, telomeric region;GO:0000786,cellular_component nucleosome;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005813,cellular_component centrosome;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006334,biological_process nucleosome assembly;GO:0006342,biological_process chromatin silencing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0010212,biological_process response to ionizing radiation;GO:0016032,biological_process viral process;GO:0016607,cellular_component nuclear speck;GO:0019899,molecular_function enzyme binding;GO:0021987,biological_process cerebral cortex development;GO:0035861,cellular_component site of double-strand break;GO:0042393,molecular_function histone binding;GO:0045739,biological_process positive regulation of DNA repair;GO:0046982,molecular_function protein heterodimerization activity;GO:0051321,biological_process meiotic cell cycle;GO:0070062,cellular_component extracellular exosome;GO:0071480,biological_process cellular response to gamma radiation;GO:0090398,biological_process cellular senescence	NA	H2A histone family member X [Source:HGNC Symbol%3BAcc:HGNC:4739]
ENSG00000125870	99.29	96.84	96.17	103.05	107.19	104.59	-0.0948515855628331	6.09841276012584	0.130065849671121	0.476359412067	20:16729960-16742563:+	SNRPB2	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0030619,molecular_function U1 snRNA binding;GO:0035614,molecular_function snRNA stem-loop binding;GO:0070990,molecular_function snRNP binding;GO:0071013,cellular_component catalytic step 2 spliceosome	SNRPB2; U2 small nuclear ribonucleoprotein B''; K11094	small nuclear ribonucleoprotein polypeptide B2 [Source:HGNC Symbol%3BAcc:HGNC:11155]
ENSG00000180806	7.24	7.84	7.45	7.68	9.63	9.29	-0.231831995575609	2.71092303260572	0.130094127681232	0.476359412067	12:53994894-54003337:+	HOXC9	12;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016235,cellular_component aggresome;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development	NA	homeobox C9 [Source:HGNC Symbol%3BAcc:HGNC:5130]
ENSG00000124641	15.24	13.32	15.69	15.46	16.77	18.48	-0.177887882221797	3.58749139402253	0.130170681813777	0.476425366156473	6:41905353-41921139:-	MED20	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	mediator complex subunit 20 [Source:HGNC Symbol%3BAcc:HGNC:16840]
ENSG00000167978	100.81	98.20	107.49	97.08	97.40	95.68	0.0909267312961115	9.71600928346613	0.130259295716327	0.476425366156473	16:2752328-2772538:+	SRRM2	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0047485,molecular_function protein N-terminus binding;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	serine/arginine repetitive matrix 2 [Source:HGNC Symbol%3BAcc:HGNC:16639]
ENSG00000019144	24.20	26.35	25.54	27.01	29.85	25.89	-0.109890775079415	6.83966112925706	0.130261332219751	0.476425366156473	11:118606439-118658038:+	PHLDB1	5;GO:0010470,biological_process regulation of gastrulation;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0045180,cellular_component basal cortex;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:1904261,biological_process positive regulation of basement membrane assembly involved in embryonic body morphogenesis	NA	pleckstrin homology like domain family B member 1 [Source:HGNC Symbol%3BAcc:HGNC:23697]
ENSG00000180089	3.85	3.38	4.23	5.30	3.36	6.43	-0.378834504762794	1.67261230580724	0.130292148214574	0.476425366156473	19:55226638-55229264:-	TMEM86B	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016803,molecular_function ether hydrolase activity;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0046485,biological_process ether lipid metabolic process;GO:0047408,molecular_function alkenylglycerophosphocholine hydrolase activity;GO:0047409,molecular_function alkenylglycerophosphoethanolamine hydrolase activity	NA	transmembrane protein 86B [Source:HGNC Symbol%3BAcc:HGNC:28448]
ENSG00000125630	10.28	10.51	10.16	11.19	11.23	11.10	-0.105360725754047	5.26640567840217	0.130304045605512	0.476425366156473	2:112541914-112577150:+	POLR1B	21;GO:0001054,molecular_function RNA polymerase I activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0007566,biological_process embryo implantation;GO:0009303,biological_process rRNA transcription;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0017126,biological_process nucleologenesis;GO:0032549,molecular_function ribonucleoside binding;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding	RPA2, POLR1B; DNA-directed RNA polymerase I subunit RPA2 [EC:2.7.7.6]; K03002	RNA polymerase I subunit B [Source:HGNC Symbol%3BAcc:HGNC:20454]
ENSG00000128944	21.98	25.23	22.40	25.69	27.52	23.76	-0.1380077481076	4.83478751588284	0.130455719565705	0.476717232030543	15:40382720-40394246:+	KNSTRN	20;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007059,biological_process chromosome segregation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0035371,cellular_component microtubule plus-end;GO:0051301,biological_process cell division;GO:0051988,biological_process regulation of attachment of spindle microtubules to kinetochore;GO:0072686,cellular_component mitotic spindle	NA	kinetochore localized astrin/SPAG5 binding protein [Source:HGNC Symbol%3BAcc:HGNC:30767]
ENSG00000133706	73.69	64.12	71.47	77.08	69.57	81.66	-0.112987753162086	8.0095196754645	0.130498582731509	0.476717232030543	5:146113037-146182660:-	LARS	32;GO:0000166,molecular_function nucleotide binding;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004819,molecular_function glutamine-tRNA ligase activity;GO:0004823,molecular_function leucine-tRNA ligase activity;GO:0004832,molecular_function valine-tRNA ligase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006425,biological_process glutaminyl-tRNA aminoacylation;GO:0006429,biological_process leucyl-tRNA aminoacylation;GO:0006438,biological_process valyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0006622,biological_process protein targeting to lysosome;GO:0008361,biological_process regulation of cell size;GO:0010507,biological_process negative regulation of autophagy;GO:0012505,cellular_component endomembrane system;GO:0016604,cellular_component nuclear body;GO:0016874,molecular_function ligase activity;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0034198,biological_process cellular response to amino acid starvation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071233,biological_process cellular response to leucine;GO:1904263,biological_process positive regulation of TORC1 signaling;GO:1990253,biological_process cellular response to leucine starvation	LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]; K01869	leucyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:6512]
ENSG00000174130	1.21	1.20	1.02	1.41	1.62	1.30	-0.323231797698313	1.69716615372788	0.130499085993699	0.476717232030543	4:38823714-38856817:-	TLR6	55;GO:0001774,biological_process microglial cell activation;GO:0001775,biological_process cell activation;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032493,biological_process response to bacterial lipoprotein;GO:0034136,biological_process negative regulation of toll-like receptor 2 signaling pathway;GO:0034150,biological_process toll-like receptor 6 signaling pathway;GO:0035355,cellular_component Toll-like receptor 2-Toll-like receptor 6 protein complex;GO:0035663,molecular_function Toll-like receptor 2 binding;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038124,biological_process toll-like receptor TLR6:TLR2 signaling pathway;GO:0042088,biological_process T-helper 1 type immune response;GO:0042496,biological_process detection of diacyl bacterial lipopeptide;GO:0042742,biological_process defense response to bacterium;GO:0042802,molecular_function identical protein binding;GO:0043032,biological_process positive regulation of macrophage activation;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043235,cellular_component receptor complex;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045410,biological_process positive regulation of interleukin-6 biosynthetic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0046209,biological_process nitric oxide metabolic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0050702,biological_process interleukin-1 beta secretion;GO:0050707,biological_process regulation of cytokine secretion;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0071723,molecular_function lipopeptide binding;GO:0071726,biological_process cellular response to diacyl bacterial lipopeptide;GO:0140052,Biological_Process cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response;GO:1900227,biological_process positive regulation of NLRP3 inflammasome complex assembly;GO:1903223,biological_process positive regulation of oxidative stress-induced neuron death;GO:1903428,biological_process positive regulation of reactive oxygen species biosynthetic process;GO:1904646,biological_process cellular response to beta-amyloid;GO:2000483,biological_process negative regulation of interleukin-8 secretion	TLR6, CD286; toll-like receptor 6; K10169	toll like receptor 6 [Source:HGNC Symbol%3BAcc:HGNC:16711]
ENSG00000180891	39.83	36.89	39.09	42.61	40.02	43.05	-0.103822243509022	5.54974284876483	0.130556920697846	0.476766918409425	17:57861242-57955323:-	CUEDC1	NA	NA	CUE domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:31350]
ENSG00000130347	12.48	11.74	11.77	14.56	12.51	13.38	-0.154141925612677	3.93779475150767	0.130589504760497	0.476766918409425	6:106571970-106629487:-	RTN4IP1	8;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0007399,biological_process nervous system development;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0050773,biological_process regulation of dendrite development;GO:0055114,biological_process oxidation-reduction process	NA	reticulon 4 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18647]
ENSG00000167513	8.67	9.04	8.54	10.65	9.26	9.53	-0.156694853362036	3.94157103874745	0.130774909181022	0.477096615573652	16:88803212-88809258:+	CDT1	35;GO:0000076,biological_process DNA replication checkpoint;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0016604,cellular_component nuclear body;GO:0030174,biological_process regulation of DNA-dependent DNA replication initiation;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0033044,biological_process regulation of chromosome organization;GO:0033262,biological_process regulation of nuclear cell cycle DNA replication;GO:0035563,biological_process positive regulation of chromatin binding;GO:0051301,biological_process cell division;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0051383,biological_process kinetochore organization;GO:0071163,biological_process DNA replication preinitiation complex assembly;GO:0072708,biological_process response to sorbitol;GO:1902426,biological_process negative regulation of mitotic spindle assembly checkpoint;GO:1902595,biological_process regulation of DNA replication origin binding;GO:1905341,biological_process negative regulation of protein localization to kinetochore;GO:1905342,biological_process positive regulation of protein localization to kinetochore;GO:2000105,biological_process positive regulation of DNA-dependent DNA replication;GO:2001178,biological_process positive regulation of mediator complex assembly	NA	chromatin licensing and DNA replication factor 1 [Source:HGNC Symbol%3BAcc:HGNC:24576]
ENSG00000100583	1.29	1.47	1.24	1.74	1.88	1.43	-0.32951803388027	1.67490194777475	0.130793190396714	0.477096615573652	14:77376688-77391497:+	SAMD15	3;GO:0000027,biological_process ribosomal large subunit assembly;GO:0006364,biological_process rRNA processing;GO:0030687,cellular_component preribosome, large subunit precursor	NA	sterile alpha motif domain containing 15 [Source:HGNC Symbol%3BAcc:HGNC:18631]
ENSG00000137100	49.53	47.47	43.48	44.15	45.39	41.08	0.117060891757493	5.37310257175569	0.130814641222323	0.477096615573652	9:34613544-34620523:-	DCTN3	28;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000910,biological_process cytokinesis;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005869,cellular_component dynactin complex;GO:0005875,cellular_component microtubule associated complex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007017,biological_process microtubule-based process;GO:0007049,biological_process cell cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030496,cellular_component midbody;GO:0032154,cellular_component cleavage furrow;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	dynactin subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:2713]
ENSG00000161860	6.28	4.67	4.36	3.66	3.26	5.10	0.362629670291295	1.69642580476973	0.13083355187406	0.477096615573652	19:12898785-12919276:-	SYCE2	6;GO:0000801,cellular_component central element;GO:0005634,cellular_component nucleus;GO:0007049,biological_process cell cycle;GO:0007130,biological_process synaptonemal complex assembly;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle	NA	synaptonemal complex central element protein 2 [Source:HGNC Symbol%3BAcc:HGNC:27411]
ENSG00000182600	1.75	2.37	0.81	2.89	1.46	3.49	-0.701586904994443	-0.113054194093071	0.130930720474948	0.477310729296779	2:232857269-232878708:+	C2orf82	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0071944,cellular_component cell periphery	NA	chromosome 2 open reading frame 82 [Source:HGNC Symbol%3BAcc:HGNC:33763]
ENSG00000187634	18.96	17.67	19.15	18.09	16.32	17.83	0.108995974157857	5.59973473525782	0.131001573541472	0.47742881161782	1:923927-944581:+	SAMD11	2;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	sterile alpha motif domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:28706]
ENSG00000161036	11.23	10.41	11.17	9.69	10.48	10.09	0.133248913451027	4.44519879977867	0.131068714245895	0.477531077999644	7:102464928-102473168:+	LRWD1	24;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000781,cellular_component chromosome, telomeric region;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0005694,cellular_component chromosome;GO:0005721,cellular_component pericentric heterochromatin;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006325,biological_process chromatin organization;GO:0008327,molecular_function methyl-CpG binding;GO:0016569,biological_process covalent chromatin modification;GO:0031933,cellular_component telomeric heterochromatin;GO:0035064,molecular_function methylated histone binding;GO:0071169,biological_process establishment of protein localization to chromatin	NA	leucine rich repeats and WD repeat domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21769]
ENSG00000096654	7.43	7.72	7.71	7.64	9.06	8.80	-0.147745387934099	4.19636871028574	0.131160393392936	0.477531077999644	6:27450742-27473118:-	ZNF184	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 184 [Source:HGNC Symbol%3BAcc:HGNC:12975]
ENSG00000163257	23.87	24.33	23.28	25.07	26.69	27.78	-0.145149805739983	4.04297564783237	0.131217668629438	0.477531077999644	4:17800654-17810758:-	DCAF16	5;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 16 [Source:HGNC Symbol%3BAcc:HGNC:25987]
ENSG00000130787	15.43	16.37	15.90	15.12	15.65	13.76	0.110172886115188	5.62576826278405	0.13122589713798	0.477531077999644	12:122834452-122862960:+	HIP1R	57;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005905,cellular_component clathrin-coated pit;GO:0005938,cellular_component cell cortex;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0012505,cellular_component endomembrane system;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030100,biological_process regulation of endocytosis;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030276,molecular_function clathrin binding;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032051,molecular_function clathrin light chain binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032587,cellular_component ruffle membrane;GO:0032839,cellular_component dendrite cytoplasm;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0034316,biological_process negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035615,molecular_function clathrin adaptor activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0046982,molecular_function protein heterodimerization activity;GO:0048268,biological_process clathrin coat assembly;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0051015,molecular_function actin filament binding;GO:0055123,biological_process digestive system development;GO:0060453,biological_process regulation of gastric acid secretion;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:0097060,cellular_component synaptic membrane;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1905445,biological_process positive regulation of clathrin coat assembly;GO:2000369,biological_process regulation of clathrin-mediated endocytosis;GO:2000588,biological_process positive regulation of platelet-derived growth factor receptor-beta signaling pathway	NA	huntingtin interacting protein 1 related [Source:HGNC Symbol%3BAcc:HGNC:18415]
ENSG00000241468	317.59	375.22	366.35	318.69	362.20	292.77	0.132294974173888	6.72551449731458	0.131248456452753	0.477531077999644	7:99448474-99466331:-	ATP5J2	19;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046034,biological_process ATP metabolic process;GO:0070062,cellular_component extracellular exosome	ATPeF0F, ATP5J2; F-type H+-transporting ATPase subunit f; K02130	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit F2 [Source:HGNC Symbol%3BAcc:HGNC:848]
ENSG00000079112	4.05	4.29	4.22	3.21	3.98	3.89	0.18827804445672	3.31681233793544	0.131260455823313	0.477531077999644	8:94127170-94217303:-	CDH17	25;GO:0002314,biological_process germinal center B cell differentiation;GO:0002315,biological_process marginal zone B cell differentiation;GO:0005178,molecular_function integrin binding;GO:0005215,molecular_function transporter activity;GO:0005427,molecular_function proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006857,biological_process oligopeptide transport;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030054,cellular_component cell junction;GO:0030183,biological_process B cell differentiation;GO:0033626,biological_process positive regulation of integrin activation by cell surface receptor linked signal transduction;GO:0034332,biological_process adherens junction organization;GO:0035672,biological_process oligopeptide transmembrane transport;GO:0046872,molecular_function metal ion binding;GO:0048536,biological_process spleen development	CDH17; cadherin 17, LI cadherin; K06811	cadherin 17 [Source:HGNC Symbol%3BAcc:HGNC:1756]
ENSG00000123684	17.75	17.65	19.96	18.75	20.84	22.11	-0.143078919613249	4.45052338341954	0.131371686746387	0.47779570688043	1:211743456-211830772:-	LPGAT1	16;GO:0003674,molecular_function molecular_function;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0045723,biological_process positive regulation of fatty acid biosynthetic process;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity	LPGAT1; lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]; K13514	lysophosphatidylglycerol acyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:28985]
ENSG00000179604	23.74	22.28	24.12	27.55	24.22	25.61	-0.12652841309588	4.72632776745217	0.131534961980228	0.478249409215165	17:73283623-73312175:-	CDC42EP4	17;GO:0003723,molecular_function RNA binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007266,biological_process Rho protein signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0012505,cellular_component endomembrane system;GO:0015629,cellular_component actin cytoskeleton;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0017049,molecular_function GTP-Rho binding;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0043547,biological_process positive regulation of GTPase activity	NA	CDC42 effector protein 4 [Source:HGNC Symbol%3BAcc:HGNC:17147]
ENSG00000159588	1.05	0.93	0.91	1.04	1.21	1.56	-0.380881829362649	1.22756798947652	0.131702891483067	0.478461568398267	1:45620043-45624057:-	CCDC17	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 17 [Source:HGNC Symbol%3BAcc:HGNC:26574]
ENSG00000148229	58.13	67.39	55.74	61.63	69.82	69.36	-0.143399893688694	4.81808436090135	0.131729615281964	0.478461568398267	9:113407234-113410672:-	POLE3	16;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0008622,cellular_component epsilon DNA polymerase complex;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0043966,biological_process histone H3 acetylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0071897,biological_process DNA biosynthetic process	POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]; K02326	DNA polymerase epsilon 3%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:13546]
ENSG00000128617	2.98	4.03	1.97	1.94	2.91	1.89	0.407766975752654	1.50101007136217	0.131741282913319	0.478461568398267	7:128772490-128775790:-	OPN1SW	18;GO:0001523,biological_process retinoid metabolic process;GO:0001750,cellular_component photoreceptor outer segment;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007601,biological_process visual perception;GO:0007602,biological_process phototransduction;GO:0008020,molecular_function G-protein coupled photoreceptor activity;GO:0009584,biological_process detection of visible light;GO:0009881,molecular_function photoreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018298,biological_process protein-chromophore linkage;GO:0050896,biological_process response to stimulus;GO:0097381,cellular_component photoreceptor disc membrane	NA	opsin 1%2C short wave sensitive [Source:HGNC Symbol%3BAcc:HGNC:1012]
ENSG00000256053	13.75	12.95	10.18	13.65	13.17	15.57	-0.192611727916622	3.80961111724943	0.131816254337915	0.478461568398267	14:103562961-103607523:+	APOPT1	6;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0034393,biological_process positive regulation of smooth muscle cell apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097193,biological_process intrinsic apoptotic signaling pathway	NA	apoptogenic 1%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:20492]
ENSG00000215440	39.69	32.46	40.14	43.27	36.46	45.18	-0.138975011901856	6.06679512426376	0.131832094377197	0.478461568398267	20:58689130-58719238:+	NPEPL1	11;GO:0004177,molecular_function aminopeptidase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0019538,biological_process protein metabolic process;GO:0030145,molecular_function manganese ion binding;GO:0046872,molecular_function metal ion binding	NA	aminopeptidase like 1 [Source:HGNC Symbol%3BAcc:HGNC:16244]
ENSG00000188677	24.24	24.81	22.39	26.82	25.71	25.33	-0.114856741861367	5.13957265235485	0.131847091984025	0.478461568398267	22:43999210-44172949:+	PARVB	18;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030027,cellular_component lamellipodium;GO:0030031,biological_process cell projection assembly;GO:0030032,biological_process lamellipodium assembly;GO:0030054,cellular_component cell junction;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0042995,cellular_component cell projection;GO:0071963,biological_process establishment or maintenance of cell polarity regulating cell shape	PARV; parvin; K06275	parvin beta [Source:HGNC Symbol%3BAcc:HGNC:14653]
ENSG00000239672	27.22	26.58	19.40	25.46	30.75	28.51	-0.202756697928112	3.87094255481323	0.131891562153125	0.478461568398267	17:51153535-51162428:+	NME1	59;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0002762,biological_process negative regulation of myeloid leukocyte differentiation;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0004536,molecular_function deoxyribonuclease activity;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006183,biological_process GTP biosynthetic process;GO:0006228,biological_process UTP biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0006259,biological_process DNA metabolic process;GO:0006897,biological_process endocytosis;GO:0007399,biological_process nervous system development;GO:0007595,biological_process lactation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009117,biological_process nucleotide metabolic process;GO:0010629,biological_process negative regulation of gene expression;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014075,biological_process response to amine;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019215,molecular_function intermediate filament binding;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0021766,biological_process hippocampus development;GO:0030154,biological_process cell differentiation;GO:0030879,biological_process mammary gland development;GO:0032587,cellular_component ruffle membrane;GO:0033574,biological_process response to testosterone;GO:0035690,biological_process cellular response to drug;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043015,molecular_function gamma-tubulin binding;GO:0043024,molecular_function ribosomal small subunit binding;GO:0043209,cellular_component myelin sheath;GO:0043388,biological_process positive regulation of DNA binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051591,biological_process response to cAMP;GO:0070062,cellular_component extracellular exosome;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071398,biological_process cellular response to fatty acid	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]; K00940	NME/NM23 nucleoside diphosphate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:7849]
ENSG00000138095	49.81	49.91	46.53	50.26	53.04	54.14	-0.0950162587524602	7.74974938179473	0.131901674620065	0.478461568398267	2:43886507-43996005:-	LRPPRC	30;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000961,biological_process negative regulation of mitochondrial RNA catabolic process;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005640,cellular_component nuclear outer membrane;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0008017,molecular_function microtubule binding;GO:0009451,biological_process RNA modification;GO:0016020,cellular_component membrane;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042645,cellular_component mitochondrial nucleoid;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048487,molecular_function beta-tubulin binding;GO:0051028,biological_process mRNA transport;GO:0070129,biological_process regulation of mitochondrial translation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	leucine rich pentatricopeptide repeat containing [Source:HGNC Symbol%3BAcc:HGNC:15714]
ENSG00000105997	49.16	50.70	50.89	46.25	46.91	49.00	0.0953314761286071	6.02345068157032	0.132166821714232	0.479283306438436	7:27106183-27152581:-	HOXA3	24;GO:0001525,biological_process angiogenesis;GO:0001974,biological_process blood vessel remodeling;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010159,biological_process specification of organ position;GO:0021615,biological_process glossopharyngeal nerve morphogenesis;GO:0030878,biological_process thyroid gland development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048538,biological_process thymus development;GO:0048645,biological_process organ formation;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0051216,biological_process cartilage development;GO:0060017,biological_process parathyroid gland development;GO:0071837,molecular_function HMG box domain binding	NA	homeobox A3 [Source:HGNC Symbol%3BAcc:HGNC:5104]
ENSG00000128591	37.87	37.54	38.70	36.31	36.12	35.95	0.0861349563247414	8.24564157034627	0.132270354699842	0.47951866614753	7:128830376-128859274:+	FLNC	17;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016020,cellular_component membrane;GO:0016528,cellular_component sarcoplasm;GO:0030018,cellular_component Z disc;GO:0030506,molecular_function ankyrin binding;GO:0034329,biological_process cell junction assembly;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0048747,biological_process muscle fiber development;GO:0051015,molecular_function actin filament binding	FLNA; filamin; K04437	filamin C [Source:HGNC Symbol%3BAcc:HGNC:3756]
ENSG00000109929	39.54	50.28	38.89	36.13	45.19	32.86	0.180840406509772	5.21567036826771	0.132336683224932	0.479619050765281	11:121292452-121308694:+	SC5D	18;GO:0000248,molecular_function C-5 sterol desaturase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0033489,biological_process cholesterol biosynthetic process via desmosterol;GO:0033490,biological_process cholesterol biosynthetic process via lathosterol;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0050046,molecular_function lathosterol oxidase activity;GO:0055114,biological_process oxidation-reduction process	SC5DL, ERG3; Delta7-sterol 5-desaturase [EC:1.14.19.20]; K00227	sterol-C5-desaturase [Source:HGNC Symbol%3BAcc:HGNC:10547]
ENSG00000174738	14.67	16.90	16.22	17.66	17.26	17.43	-0.124804517937688	4.92787192768221	0.132447462915089	0.479765249822725	3:23945259-23980618:+	NR1D2	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001206,molecular_function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0042752,biological_process regulation of circadian rhythm;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0050727,biological_process regulation of inflammatory response;GO:0055088,biological_process lipid homeostasis;GO:2000505,biological_process regulation of energy homeostasis;GO:2001014,biological_process regulation of skeletal muscle cell differentiation	NA	nuclear receptor subfamily 1 group D member 2 [Source:HGNC Symbol%3BAcc:HGNC:7963]
ENSG00000188725	71.90	53.81	65.31	79.93	61.15	80.77	-0.196120475514109	3.95750599106451	0.132454322979334	0.479765249822725	5:61157708-61162474:-	SMIM15	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 15 [Source:HGNC Symbol%3BAcc:HGNC:33861]
ENSG00000169016	14.93	12.76	11.30	12.91	16.87	15.49	-0.201395686068781	3.67975148912526	0.132611146771524	0.48019316361579	2:11444374-11466177:-	E2F6	17;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0046983,molecular_function protein dimerization activity;GO:0071339,cellular_component MLL1 complex;GO:0090575,cellular_component RNA polymerase II transcription factor complex	NA	E2F transcription factor 6 [Source:HGNC Symbol%3BAcc:HGNC:3120]
ENSG00000134690	34.72	43.57	33.73	40.56	45.78	39.09	-0.157880914553786	5.05850332260936	0.132656308664763	0.480216611098192	1:37692417-37709719:+	CDCA8	23;GO:0000775,cellular_component chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007080,biological_process mitotic metaphase plate congression;GO:0010369,cellular_component chromocenter;GO:0016604,cellular_component nuclear body;GO:0016925,biological_process protein sumoylation;GO:0030496,cellular_component midbody;GO:0032133,cellular_component chromosome passenger complex;GO:0043234,cellular_component protein complex;GO:0045171,cellular_component intercellular bridge;GO:0051233,cellular_component spindle midzone;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division	NA	cell division cycle associated 8 [Source:HGNC Symbol%3BAcc:HGNC:14629]
ENSG00000119720	4.75	4.50	4.56	5.80	5.34	4.49	-0.163550750102061	4.12623974074925	0.132706184740023	0.480253075699872	14:90267855-90332137:-	NRDE2	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016246,biological_process RNA interference;GO:0031048,biological_process chromatin silencing by small RNA;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	NRDE-2%2C necessary for RNA interference%2C domain containing [Source:HGNC Symbol%3BAcc:HGNC:20186]
ENSG00000214954	3.45	2.69	3.52	2.46	2.85	2.58	0.322391590714044	1.7135527756614	0.132743760793222	0.480253075699872	8:91101831-91219236:+	LRRC69	NA	NA	leucine rich repeat containing 69 [Source:HGNC Symbol%3BAcc:HGNC:34303]
ENSG00000178999	40.18	41.20	37.45	45.02	42.94	41.24	-0.110868388620027	5.48708830655781	0.132828122928307	0.480366770138049	17:8204732-8210600:-	AURKB	61;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0002903,biological_process negative regulation of B cell apoptotic process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007568,biological_process aging;GO:0008283,biological_process cell proliferation;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0009838,biological_process abscission;GO:0010369,cellular_component chromocenter;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016570,biological_process histone modification;GO:0016740,molecular_function transferase activity;GO:0016925,biological_process protein sumoylation;GO:0030496,cellular_component midbody;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031577,biological_process spindle checkpoint;GO:0031616,cellular_component spindle pole centrosome;GO:0032091,biological_process negative regulation of protein binding;GO:0032133,cellular_component chromosome passenger complex;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032466,biological_process negative regulation of cytokinesis;GO:0032467,biological_process positive regulation of cytokinesis;GO:0034501,biological_process protein localization to kinetochore;GO:0034644,biological_process cellular response to UV;GO:0035174,molecular_function histone serine kinase activity;GO:0036089,biological_process cleavage furrow formation;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043988,biological_process histone H3-S28 phosphorylation;GO:0044878,biological_process mitotic cytokinesis checkpoint;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051233,cellular_component spindle midzone;GO:0051256,biological_process mitotic spindle midzone assembly;GO:0051301,biological_process cell division;GO:0051973,biological_process positive regulation of telomerase activity;GO:0051983,biological_process regulation of chromosome segregation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904355,biological_process positive regulation of telomere capping;GO:1990023,cellular_component mitotic spindle midzone	NA	aurora kinase B [Source:HGNC Symbol%3BAcc:HGNC:11390]
ENSG00000115946	15.67	14.92	14.77	17.81	16.63	16.64	-0.157700462149052	3.71721372860596	0.132852583733499	0.480366770138049	2:68157843-68176238:+	PNO1	7;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing	NA	partner of NOB1 homolog [Source:HGNC Symbol%3BAcc:HGNC:32790]
ENSG00000114503	91.89	100.10	98.85	89.90	93.00	89.95	0.101713268276718	5.68980677525683	0.13299622418438	0.480675221591835	3:196935401-196942597:-	NCBP2	40;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000339,molecular_function RNA cap binding;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005845,cellular_component mRNA cap binding complex;GO:0005846,cellular_component nuclear cap binding complex;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006408,biological_process snRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0006810,biological_process transport;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0017069,molecular_function snRNA binding;GO:0031047,biological_process gene silencing by RNA;GO:0031124,biological_process mRNA 3'-end processing;GO:0031442,biological_process positive regulation of mRNA 3'-end processing;GO:0034518,cellular_component RNA cap binding complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0046833,biological_process positive regulation of RNA export from nucleus;GO:0051028,biological_process mRNA transport;GO:0051168,biological_process nuclear export;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation	NCBP2, CBP20; nuclear cap-binding protein subunit 2; K12883	nuclear cap binding protein subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:7659]
ENSG00000211460	42.77	42.66	42.66	46.67	46.41	45.51	-0.101625766302755	5.4231125177974	0.133021857647283	0.480675221591835	2:121737102-121767853:+	TSN	18;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006310,biological_process DNA recombination;GO:0016070,biological_process RNA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0032403,molecular_function protein complex binding;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	translin [Source:HGNC Symbol%3BAcc:HGNC:12379]
ENSG00000124766	39.09	41.60	38.56	30.96	40.91	37.53	0.134698150273803	5.76318931238488	0.133054061176955	0.480675221591835	6:21592767-21598619:+	SOX4	60;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001071,molecular_function nucleic acid binding transcription factor activity;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001501,biological_process skeletal system development;GO:0001841,biological_process neural tube formation;GO:0002328,biological_process pro-B cell differentiation;GO:0003183,biological_process mitral valve morphogenesis;GO:0003211,biological_process cardiac ventricle formation;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0003289,biological_process atrial septum primum morphogenesis;GO:0003357,biological_process noradrenergic neuron differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007507,biological_process heart development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014009,biological_process glial cell proliferation;GO:0021510,biological_process spinal cord development;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021782,biological_process glial cell development;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030217,biological_process T cell differentiation;GO:0031018,biological_process endocrine pancreas development;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031647,biological_process regulation of protein stability;GO:0032024,biological_process positive regulation of insulin secretion;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035910,biological_process ascending aorta morphogenesis;GO:0042593,biological_process glucose homeostasis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043065,biological_process positive regulation of apoptotic process;GO:0044798,cellular_component nuclear transcription factor complex;GO:0045727,biological_process positive regulation of translation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046826,biological_process negative regulation of protein export from nucleus;GO:0046982,molecular_function protein heterodimerization activity;GO:0048485,biological_process sympathetic nervous system development;GO:0050821,biological_process protein stabilization;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060174,biological_process limb bud formation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060548,biological_process negative regulation of cell death;GO:0060563,biological_process neuroepithelial cell differentiation;GO:0060993,biological_process kidney morphogenesis;GO:0071333,biological_process cellular response to glucose stimulus;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:2000761,biological_process positive regulation of N-terminal peptidyl-lysine acetylation	NA	SRY-box 4 [Source:HGNC Symbol%3BAcc:HGNC:11200]
ENSG00000100288	29.32	26.61	30.37	25.97	28.86	24.98	0.129879423492637	5.04445077382598	0.133165049260323	0.4809362107851	22:50578948-50601455:-	CHKB	14;GO:0000166,molecular_function nucleotide binding;GO:0004103,molecular_function choline kinase activity;GO:0004305,molecular_function ethanolamine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006657,biological_process CDP-choline pathway;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046474,biological_process glycerophospholipid biosynthetic process	CHK; choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]; K14156	choline kinase beta [Source:HGNC Symbol%3BAcc:HGNC:1938]
ENSG00000166192	5.22	5.26	5.09	3.65	5.25	3.54	0.338545483956458	1.63483227230691	0.133307441141005	0.481310432484962	15:72114257-72143688:+	SENP8	12;GO:0004175,molecular_function endopeptidase activity;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016926,biological_process protein desumoylation;GO:0016929,molecular_function SUMO-specific protease activity;GO:0019784,molecular_function NEDD8-specific protease activity;GO:0043687,biological_process post-translational protein modification	NA	SUMO/sentrin peptidase family member%2C NEDD8 specific [Source:HGNC Symbol%3BAcc:HGNC:22992]
ENSG00000077458	16.81	15.87	18.13	16.58	19.03	21.86	-0.163841268696159	4.3064944921097	0.133516945717037	0.481917998843316	11:95768941-95790409:-	FAM76B	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck	NA	family with sequence similarity 76 member B [Source:HGNC Symbol%3BAcc:HGNC:28492]
ENSG00000167644	7.87	5.32	6.83	9.14	8.05	8.39	-0.317135259011019	1.60854675658977	0.133640687618736	0.481917998843316	19:38304160-38305009:+	C19orf33	4;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process	NA	chromosome 19 open reading frame 33 [Source:HGNC Symbol%3BAcc:HGNC:16668]
ENSG00000115762	26.23	24.43	24.53	22.11	22.95	24.75	0.120071664054792	4.90923706560564	0.133693287272713	0.481917998843316	2:131104846-131353709:+	PLEKHB2	7;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005768,cellular_component endosome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045595,biological_process regulation of cell differentiation;GO:0055038,cellular_component recycling endosome membrane	NA	pleckstrin homology domain containing B2 [Source:HGNC Symbol%3BAcc:HGNC:19236]
ENSG00000184661	10.69	10.38	10.28	10.85	11.92	11.40	-0.111546070981453	5.08243432999102	0.133694199501793	0.481917998843316	8:25458996-25507920:+	CDCA2	8;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0051301,biological_process cell division	NA	cell division cycle associated 2 [Source:HGNC Symbol%3BAcc:HGNC:14623]
ENSG00000142192	973.29	978.37	996.04	931.63	949.49	925.31	0.0826249702470528	11.1762873262491	0.133705444645856	0.481917998843316	21:25880549-26171128:-	APP	126;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001967,biological_process suckling behavior;GO:0002265,biological_process astrocyte activation involved in immune response;GO:0002576,biological_process platelet degranulation;GO:0003677,molecular_function DNA binding;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005641,cellular_component nuclear envelope lumen;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005911,cellular_component cell-cell junction;GO:0006378,biological_process mRNA polyadenylation;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0006878,biological_process cellular copper ion homeostasis;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0007155,biological_process cell adhesion;GO:0007176,biological_process regulation of epidermal growth factor-activated receptor activity;GO:0007219,biological_process Notch signaling pathway;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0007611,biological_process learning or memory;GO:0007617,biological_process mating behavior;GO:0007626,biological_process locomotory behavior;GO:0008088,biological_process axo-dendritic transport;GO:0008201,molecular_function heparin binding;GO:0008203,biological_process cholesterol metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008344,biological_process adult locomotory behavior;GO:0008542,biological_process visual learning;GO:0009986,cellular_component cell surface;GO:0009987,biological_process cellular process;GO:0010288,biological_process response to lead ion;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0010952,biological_process positive regulation of peptidase activity;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0014005,biological_process microglia development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016199,biological_process axon midline choice point recognition;GO:0016322,biological_process neuron remodeling;GO:0016358,biological_process dendrite development;GO:0016504,molecular_function peptidase activator activity;GO:0019899,molecular_function enzyme binding;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030198,biological_process extracellular matrix organization;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030900,biological_process forebrain development;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031175,biological_process neuron projection development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031594,cellular_component neuromuscular junction;GO:0031904,cellular_component endosome lumen;GO:0032588,cellular_component trans-Golgi network membrane;GO:0032640,biological_process tumor necrosis factor production;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0035253,cellular_component ciliary rootlet;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043195,cellular_component terminal bouton;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0043235,cellular_component receptor complex;GO:0043393,biological_process regulation of protein binding;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0044304,cellular_component main axon;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045177,cellular_component apical part of cell;GO:0045202,cellular_component synapse;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0046914,molecular_function transition metal ion binding;GO:0048143,biological_process astrocyte activation;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048669,biological_process collateral sprouting in absence of injury;GO:0050803,biological_process regulation of synapse structure or activity;GO:0050808,biological_process synapse organization;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051124,biological_process synaptic growth at neuromuscular junction;GO:0051233,cellular_component spindle midzone;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0051402,biological_process neuron apoptotic process;GO:0051425,molecular_function PTB domain binding;GO:0051563,biological_process smooth endoplasmic reticulum calcium ion homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0070851,molecular_function growth factor receptor binding;GO:0071320,biological_process cellular response to cAMP;GO:0071874,biological_process cellular response to norepinephrine stimulus;GO:0090647,biological_process modulation of age-related behavioral decline;GO:0097449,cellular_component astrocyte projection;GO:0098815,biological_process modulation of excitatory postsynaptic potential;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1904646,biological_process cellular response to beta-amyloid;GO:1990000,biological_process amyloid fibril formation;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990761,cellular_component growth cone lamellipodium;GO:1990812,cellular_component growth cone filopodium;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity	APP; amyloid beta A4 protein; K04520	amyloid beta precursor protein [Source:HGNC Symbol%3BAcc:HGNC:620]
ENSG00000088356	61.78	62.27	59.77	70.18	62.35	69.61	-0.127384500187959	4.69201742699112	0.133708659310109	0.481917998843316	20:31944341-31952092:-	PDRG1	4;GO:0005737,cellular_component cytoplasm;GO:0006457,biological_process protein folding;GO:0016272,cellular_component prefoldin complex;GO:0051082,molecular_function unfolded protein binding	NA	p53 and DNA damage regulated 1 [Source:HGNC Symbol%3BAcc:HGNC:16119]
ENSG00000161692	6.36	6.71	5.48	6.78	7.68	6.67	-0.18146578137207	3.64204263468449	0.133763589912384	0.481933830635986	17:44708607-44752264:+	DBF4B	16;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010571,biological_process positive regulation of nuclear cell cycle DNA replication;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016235,cellular_component aggresome;GO:0019901,molecular_function protein kinase binding;GO:0030295,molecular_function protein kinase activator activity;GO:0032147,biological_process activation of protein kinase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	NA	DBF4 zinc finger B [Source:HGNC Symbol%3BAcc:HGNC:17883]
ENSG00000126953	19.90	22.66	22.26	20.33	15.64	19.09	0.239633248475564	2.57190964623457	0.133790701713656	0.481933830635986	X:101345660-101349196:-	TIMM8A	10;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006810,biological_process transport;GO:0007399,biological_process nervous system development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0046872,molecular_function metal ion binding;GO:0072321,biological_process chaperone-mediated protein transport	NA	translocase of inner mitochondrial membrane 8A [Source:HGNC Symbol%3BAcc:HGNC:11817]
ENSG00000125835	177.60	185.03	156.41	189.62	183.26	190.66	-0.10826799461351	7.14440599768188	0.133895028078264	0.482142286326868	20:2461633-2470853:-	SNRPB	35;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005683,cellular_component U7 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006479,biological_process protein methylation;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0030620,molecular_function U2 snRNA binding;GO:0034709,cellular_component methylosome;GO:0034719,cellular_component SMN-Sm protein complex;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0051170,biological_process nuclear import;GO:0070034,molecular_function telomerase RNA binding;GO:0070062,cellular_component extracellular exosome;GO:0071004,cellular_component U2-type prespliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071204,cellular_component histone pre-mRNA 3'end processing complex;GO:0071208,molecular_function histone pre-mRNA DCP binding	SNRPB, SMB; small nuclear ribonucleoprotein B and B'; K11086	small nuclear ribonucleoprotein polypeptides B and B1 [Source:HGNC Symbol%3BAcc:HGNC:11153]
ENSG00000116957	30.55	30.09	29.41	35.49	31.36	31.10	-0.109392751559145	5.76910506379769	0.13392625499517	0.482142286326868	1:235367359-235448968:+	TBCE	15;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0007023,biological_process post-chaperonin tubulin folding pathway;GO:0007052,biological_process mitotic spindle organization;GO:0007409,biological_process axonogenesis;GO:0008344,biological_process adult locomotory behavior;GO:0009791,biological_process post-embryonic development;GO:0014889,biological_process muscle atrophy;GO:0048589,biological_process developmental growth;GO:0048936,biological_process peripheral nervous system neuron axonogenesis;GO:0051087,molecular_function chaperone binding	NA	tubulin folding cofactor E [Source:HGNC Symbol%3BAcc:HGNC:11582]
ENSG00000178860	70.17	49.79	66.69	56.94	47.49	62.01	0.181717690219272	5.19693933225375	0.134064953842627	0.48250167354263	8:71841548-71844468:-	MSC	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001206,molecular_function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0014707,biological_process branchiomeric skeletal muscle development;GO:0046983,molecular_function protein dimerization activity;GO:0060021,biological_process palate development;GO:0060539,biological_process diaphragm development;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	musculin [Source:HGNC Symbol%3BAcc:HGNC:7321]
ENSG00000134461	4.50	3.71	4.01	3.94	5.60	5.45	-0.275875107500637	2.35009778293753	0.134274657243014	0.483116324741314	10:5861616-5889906:-	ANKRD16	NA	NA	ankyrin repeat domain 16 [Source:HGNC Symbol%3BAcc:HGNC:23471]
ENSG00000088387	2.60	2.32	2.68	2.52	2.12	2.26	0.159613914792867	4.12893259628962	0.134365213603021	0.483129295734217	13:98793428-99086625:-	DOCK9	11;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007596,biological_process blood coagulation;GO:0008150,biological_process biological_process;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding	NA	dedicator of cytokinesis 9 [Source:HGNC Symbol%3BAcc:HGNC:14132]
ENSG00000125355	1.41	1.55	1.89	1.64	1.01	0.87	0.47837168512891	0.686494704687925	0.134395951288361	0.483129295734217	X:120258649-120311556:-	TMEM255A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 255A [Source:HGNC Symbol%3BAcc:HGNC:26086]
ENSG00000125841	42.77	40.23	42.62	37.71	33.38	43.52	0.14423429231125	4.77068237034113	0.134455673336696	0.483129295734217	20:346781-359660:+	NRSN2	8;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043025,cellular_component neuronal cell body	NA	neurensin 2 [Source:HGNC Symbol%3BAcc:HGNC:16229]
ENSG00000184445	8.38	8.93	7.72	9.12	9.03	8.97	-0.107491495398735	5.85140585176076	0.134466073976601	0.483129295734217	12:122527245-122626396:+	KNTC1	21;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005828,cellular_component kinetochore microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007096,biological_process regulation of exit from mitosis;GO:0015629,cellular_component actin cytoskeleton;GO:0051301,biological_process cell division;GO:1990423,cellular_component RZZ complex	NA	kinetochore associated 1 [Source:HGNC Symbol%3BAcc:HGNC:17255]
ENSG00000103313	1.06	0.45	0.90	1.32	0.57	1.66	-0.528511278151698	1.58201563902649	0.134472868505737	0.483129295734217	16:3242027-3256627:-	MEFV	29;GO:0001726,cellular_component ruffle;GO:0002376,biological_process immune system process;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0006954,biological_process inflammatory response;GO:0008270,molecular_function zinc ion binding;GO:0010508,biological_process positive regulation of autophagy;GO:0030027,cellular_component lamellipodium;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032691,biological_process negative regulation of interleukin-1 beta production;GO:0032695,biological_process negative regulation of interleukin-12 production;GO:0034341,biological_process response to interferon-gamma;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0071641,biological_process negative regulation of macrophage inflammatory protein 1 alpha production;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response;GO:1900226,biological_process negative regulation of NLRP3 inflammasome complex assembly;GO:2001056,biological_process positive regulation of cysteine-type endopeptidase activity	MEFV; pyrin; K12803	MEFV%2C pyrin innate immunity regulator [Source:HGNC Symbol%3BAcc:HGNC:6998]
ENSG00000100916	7.92	9.68	7.96	6.33	8.58	6.98	0.225601789261663	3.02465688841256	0.134558087199815	0.483164417071167	14:35826317-35932325:+	BRMS1L	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016575,biological_process histone deacetylation;GO:0040008,biological_process regulation of growth;GO:0042826,molecular_function histone deacetylase binding;GO:0070822,cellular_component Sin3-type complex	NA	breast cancer metastasis-suppressor 1 like [Source:HGNC Symbol%3BAcc:HGNC:20512]
ENSG00000107262	27.67	28.64	24.79	21.47	25.98	26.64	0.138916765398824	5.00630300812057	0.134560492210991	0.483164417071167	9:33247819-33264720:-	BAG1	13;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0050790,biological_process regulation of catalytic activity;GO:0051087,molecular_function chaperone binding;GO:0070389,biological_process chaperone cofactor-dependent protein refolding;GO:1900034,biological_process regulation of cellular response to heat	BAG1; BCL2-associated athanogene 1; K09555	BCL2 associated athanogene 1 [Source:HGNC Symbol%3BAcc:HGNC:937]
ENSG00000156136	22.23	23.70	21.26	24.98	25.38	23.60	-0.130807085726174	4.57092196459313	0.134614649097208	0.483181750726565	4:70992537-71030914:+	DCK	17;GO:0000166,molecular_function nucleotide binding;GO:0004137,molecular_function deoxycytidine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006220,biological_process pyrimidine nucleotide metabolic process;GO:0008144,molecular_function drug binding;GO:0009157,biological_process deoxyribonucleoside monophosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0043101,biological_process purine-containing compound salvage	DCK; deoxycitidine kinase [EC:2.7.1.74]; K00893	deoxycytidine kinase [Source:HGNC Symbol%3BAcc:HGNC:2704]
ENSG00000014216	81.00	83.07	78.33	73.38	82.64	70.94	0.106414269765446	7.40514612703736	0.134643170527929	0.483181750726565	11:65180565-65212006:+	CAPN1	29;GO:0004175,molecular_function endopeptidase activity;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0032801,biological_process receptor catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0050790,biological_process regulation of catalytic activity;GO:0060056,biological_process mammary gland involution;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0097264,biological_process self proteolysis;GO:1904813,cellular_component ficolin-1-rich granule lumen	CAPN1; calpain-1 [EC:3.4.22.52]; K01367	calpain 1 [Source:HGNC Symbol%3BAcc:HGNC:1476]
ENSG00000176396	14.46	14.44	11.64	16.50	15.53	14.60	-0.193397498837845	3.38400159769719	0.134784789673159	0.483550171737839	19:39538704-39540333:-	EID2	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007181,biological_process transforming growth factor beta receptor complex assembly;GO:0007183,biological_process SMAD protein complex assembly;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030154,biological_process cell differentiation;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046332,molecular_function SMAD binding	NA	EP300 interacting inhibitor of differentiation 2 [Source:HGNC Symbol%3BAcc:HGNC:28292]
ENSG00000244405	6.24	5.47	5.92	8.48	4.94	7.88	-0.259526658837581	3.44218129736896	0.134838362215064	0.483602597565903	3:186046307-186110318:-	ETV5	24;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0007626,biological_process locomotory behavior;GO:0030154,biological_process cell differentiation;GO:0034599,biological_process cellular response to oxidative stress;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048133,biological_process male germ-line stem cell asymmetric division;GO:0050807,biological_process regulation of synapse organization;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0060762,biological_process regulation of branching involved in mammary gland duct morphogenesis;GO:0071340,biological_process skeletal muscle acetylcholine-gated channel clustering	ETV5; ets translocation variant 5; K15593	ETS variant 5 [Source:HGNC Symbol%3BAcc:HGNC:3494]
ENSG00000269335	5.50	7.06	6.27	5.32	5.86	5.35	0.188342251435779	3.39783801357656	0.134902825640179	0.483694042366131	X:154541198-154565046:+	IKBKG	47;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000187,biological_process activation of MAPK activity;GO:0000922,cellular_component spindle pole;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0008385,cellular_component IkappaB kinase complex;GO:0009615,biological_process response to virus;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016032,biological_process viral process;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016579,biological_process protein deubiquitination;GO:0019904,molecular_function protein domain specific binding;GO:0031593,molecular_function polyubiquitin binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043276,biological_process anoikis;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051650,biological_process establishment of vesicle localization;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0072686,cellular_component mitotic spindle;GO:1901215,biological_process negative regulation of neuron death;GO:1990450,molecular_function linear polyubiquitin binding	IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma; K07210	inhibitor of nuclear factor kappa B kinase subunit gamma [Source:HGNC Symbol%3BAcc:HGNC:5961]
ENSG00000196586	28.96	31.76	31.01	27.04	29.95	29.14	0.10159428881905	6.84962286329044	0.135025565744259	0.483994325031327	6:75749191-75919537:+	MYO6	48;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005905,cellular_component clathrin-coated pit;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007605,biological_process sensory perception of sound;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016459,cellular_component myosin complex;GO:0016461,cellular_component unconventional myosin complex;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0030048,biological_process actin filament-based movement;GO:0030139,cellular_component endocytic vesicle;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031941,cellular_component filamentous actin;GO:0031965,cellular_component nuclear membrane;GO:0032587,cellular_component ruffle membrane;GO:0042493,biological_process response to drug;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043531,molecular_function ADP binding;GO:0045177,cellular_component apical part of cell;GO:0045296,molecular_function cadherin binding;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051015,molecular_function actin filament binding;GO:0051046,biological_process regulation of secretion;GO:0060001,molecular_function minus-end directed microfilament motor activity;GO:0070062,cellular_component extracellular exosome	MYO6; myosin VI; K10358	myosin VI [Source:HGNC Symbol%3BAcc:HGNC:7605]
ENSG00000121864	29.71	29.95	27.21	31.18	32.06	30.98	-0.107151369955684	5.46228822032277	0.135226607189551	0.484335076220159	3:179322990-179338583:+	ZNF639	20;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030307,biological_process positive regulation of cell growth;GO:0043621,molecular_function protein self-association;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 639 [Source:HGNC Symbol%3BAcc:HGNC:30950]
ENSG00000137806	17.36	15.88	17.43	14.15	15.47	16.51	0.150515616254288	4.0350762879831	0.135229458100646	0.484335076220159	15:41387348-41402519:-	NDUFAF1	9;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005829,cellular_component cytosol;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006461,biological_process protein complex assembly;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0051082,molecular_function unfolded protein binding	NA	NADH:ubiquinone oxidoreductase complex assembly factor 1 [Source:HGNC Symbol%3BAcc:HGNC:18828]
ENSG00000113569	19.91	19.42	19.98	21.58	21.66	20.63	-0.0941005760198224	6.42633670162772	0.13524966139211	0.484335076220159	5:37288136-37371181:-	NUP155	30;GO:0000972,biological_process transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0006110,biological_process regulation of glycolytic process;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006998,biological_process nuclear envelope organization;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0036228,biological_process protein targeting to nuclear inner membrane;GO:0043657,cellular_component host cell;GO:0044611,cellular_component nuclear pore inner ring;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:0086014,biological_process atrial cardiac muscle cell action potential;GO:1900034,biological_process regulation of cellular response to heat	NUP155, NUP170, NUP157; nuclear pore complex protein Nup155; K14312	nucleoporin 155 [Source:HGNC Symbol%3BAcc:HGNC:8063]
ENSG00000149084	39.88	36.19	38.01	41.99	39.46	42.18	-0.101478745971303	5.70116785539263	0.135276702590453	0.484335076220159	11:43680557-43856617:+	HSD17B12	24;GO:0001968,molecular_function fibronectin binding;GO:0004303,molecular_function estradiol 17-beta-dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006703,biological_process estrogen biosynthetic process;GO:0008201,molecular_function heparin binding;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016509,molecular_function long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0030198,biological_process extracellular matrix organization;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0055114,biological_process oxidation-reduction process;GO:0102339,molecular_function 3-oxo-arachidoyl-CoA reductase activity;GO:0102340,molecular_function 3-oxo-behenoyl-CoA reductase activity;GO:0102341,molecular_function 3-oxo-lignoceroyl-CoA reductase activity;GO:0102342,molecular_function 3-oxo-cerotoyl-CoA reductase activity	HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]; K10251	hydroxysteroid 17-beta dehydrogenase 12 [Source:HGNC Symbol%3BAcc:HGNC:18646]
ENSG00000155034	3.75	3.40	4.28	4.39	3.94	4.91	-0.194494467837163	3.42546611904148	0.135429054360968	0.484631684113951	7:5431334-5513798:-	FBXL18	6;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 18 [Source:HGNC Symbol%3BAcc:HGNC:21874]
ENSG00000148384	9.14	9.20	7.92	7.67	7.30	8.70	0.156148862374629	4.01919554545259	0.135501241851431	0.484631684113951	9:136428618-136439823:-	INPP5E	21;GO:0000139,cellular_component Golgi membrane;GO:0001726,cellular_component ruffle;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445,molecular_function inositol-polyphosphate 5-phosphatase activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0032580,cellular_component Golgi cisterna membrane;GO:0042995,cellular_component cell projection;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation	INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]; K01099	inositol polyphosphate-5-phosphatase E [Source:HGNC Symbol%3BAcc:HGNC:21474]
ENSG00000116285	591.51	410.91	629.94	736.40	483.10	711.12	-0.230370697087962	9.77178753299665	0.135523986464063	0.484631684113951	1:8004403-8026308:-	ERRFI1	34;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006950,biological_process response to stress;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031267,molecular_function small GTPase binding;GO:0031953,biological_process negative regulation of protein autophosphorylation;GO:0032691,biological_process negative regulation of interleukin-1 beta production;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032966,biological_process negative regulation of collagen biosynthetic process;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042536,biological_process negative regulation of tumor necrosis factor biosynthetic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043589,biological_process skin morphogenesis;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0048286,biological_process lung alveolus development;GO:0050732,biological_process negative regulation of peptidyl-tyrosine phosphorylation;GO:0060426,biological_process lung vasculature development;GO:0060428,biological_process lung epithelium development;GO:0061469,biological_process regulation of type B pancreatic cell proliferation;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071474,biological_process cellular hyperosmotic response;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:1903243,biological_process negative regulation of cardiac muscle hypertrophy in response to stress	NA	ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:18185]
ENSG00000105401	118.54	119.77	119.42	125.30	132.11	126.37	-0.0897298675315168	7.48656907577986	0.135545239469704	0.484631684113951	19:10391133-10420121:-	CDC37	25;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006605,biological_process protein targeting;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019887,molecular_function protein kinase regulator activity;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0031072,molecular_function heat shock protein binding;GO:0038128,biological_process ERBB2 signaling pathway;GO:0045859,biological_process regulation of protein kinase activity;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051301,biological_process cell division;GO:0051879,molecular_function Hsp90 protein binding;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0098779,biological_process mitophagy in response to mitochondrial depolarization;GO:1990565,cellular_component HSP90-CDC37 chaperone complex	CDC37; cell division cycle protein 37; K09554	cell division cycle 37 [Source:HGNC Symbol%3BAcc:HGNC:1735]
ENSG00000143195	2.35	2.55	2.11	1.55	2.60	1.38	0.354174047957939	2.09180366506401	0.135554757693035	0.484631684113951	1:166895710-166975482:-	ILDR2	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030073,biological_process insulin secretion;GO:0030154,biological_process cell differentiation;GO:0031016,biological_process pancreas development;GO:0048873,biological_process homeostasis of number of cells within a tissue	NA	immunoglobulin like domain containing receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:18131]
ENSG00000124222	11.53	11.63	13.21	10.71	9.61	11.98	0.182863481235541	3.51717766900426	0.13576526465093	0.485021943733827	20:58651252-58679526:+	STX16	24;GO:0000139,cellular_component Golgi membrane;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006906,biological_process vesicle fusion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0031201,cellular_component SNARE complex;GO:0031985,cellular_component Golgi cisterna;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048278,biological_process vesicle docking;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090161,biological_process Golgi ribbon formation	STX16; syntaxin 16; K08489	syntaxin 16 [Source:HGNC Symbol%3BAcc:HGNC:11431]
ENSG00000124067	10.34	11.12	10.84	10.34	10.22	9.56	0.110265943083887	5.20424197215585	0.135771990908336	0.485021943733827	16:67943473-67969601:-	SLC12A4	20;GO:0005215,molecular_function transporter activity;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006821,biological_process chloride transport;GO:0006884,biological_process cell volume homeostasis;GO:0007268,biological_process chemical synaptic transmission;GO:0015293,molecular_function symporter activity;GO:0015377,molecular_function cation:chloride symporter activity;GO:0015379,molecular_function potassium:chloride symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0022820,molecular_function potassium ion symporter activity;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 12 member 4 [Source:HGNC Symbol%3BAcc:HGNC:10913]
ENSG00000047648	3.70	4.24	3.65	2.87	3.79	3.53	0.189366028327255	3.55328179931103	0.135806768355851	0.485021943733827	X:11137542-11665701:-	ARHGAP6	18;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0007015,biological_process actin filament organization;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0015629,cellular_component actin cytoskeleton;GO:0017124,molecular_function SH3 domain binding;GO:0030041,biological_process actin filament polymerization;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048041,biological_process focal adhesion assembly;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0051895,biological_process negative regulation of focal adhesion assembly	NA	Rho GTPase activating protein 6 [Source:HGNC Symbol%3BAcc:HGNC:676]
ENSG00000168556	10.37	10.82	7.84	9.57	11.99	12.69	-0.234658986278217	3.25733291651123	0.135842069830874	0.485021943733827	4:183504993-183511096:+	ING2	35;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007141,biological_process male meiosis I;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016580,cellular_component Sin3 complex;GO:0016602,cellular_component CCAAT-binding factor complex;GO:0030317,biological_process sperm motility;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0032403,molecular_function protein complex binding;GO:0035064,molecular_function methylated histone binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0040008,biological_process regulation of growth;GO:0042981,biological_process regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048133,biological_process male germ-line stem cell asymmetric division;GO:0072520,biological_process seminiferous tubule development;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000772,biological_process regulation of cellular senescence;GO:2001020,biological_process regulation of response to DNA damage stimulus;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	NA	inhibitor of growth family member 2 [Source:HGNC Symbol%3BAcc:HGNC:6063]
ENSG00000166450	0.47	0.50	0.51	0.67	0.70	0.57	-0.379194848457232	1.08942365279677	0.135859284489045	0.485021943733827	15:55611545-55743090:-	PRTG	4;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protogenin [Source:HGNC Symbol%3BAcc:HGNC:26373]
ENSG00000184898	10.60	14.05	11.23	10.07	11.21	10.45	0.177513544535752	3.84719104543988	0.135938549381086	0.485102652058287	2:151247939-151261879:-	RBM43	2;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding	NA	RNA binding motif protein 43 [Source:HGNC Symbol%3BAcc:HGNC:24790]
ENSG00000100938	52.54	50.82	52.63	51.58	47.63	47.89	0.0974223437150248	6.27318518171426	0.135960052083363	0.485102652058287	14:24232421-24239242:+	GMPR2	14;GO:0003824,molecular_function catalytic activity;GO:0003920,molecular_function GMP reductase activity;GO:0003938,molecular_function IMP dehydrogenase activity;GO:0005829,cellular_component cytosol;GO:0006144,biological_process purine nucleobase metabolic process;GO:0006163,biological_process purine nucleotide metabolic process;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0009117,biological_process nucleotide metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0043101,biological_process purine-containing compound salvage;GO:0046037,biological_process GMP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:1902560,cellular_component GMP reductase complex	E1.7.1.7, guaC; GMP reductase [EC:1.7.1.7]; K00364	guanosine monophosphate reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:4377]
ENSG00000203780	7.71	5.80	6.42	7.74	7.70	7.94	-0.205064386232051	2.96610180543431	0.136345109143426	0.486234961319748	10:125896538-126009592:+	FANK1	8;GO:0000785,cellular_component chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0042981,biological_process regulation of apoptotic process;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity	NA	fibronectin type III and ankyrin repeat domains 1 [Source:HGNC Symbol%3BAcc:HGNC:23527]
ENSG00000132623	6.52	5.83	6.10	6.95	7.04	6.68	-0.144789604365045	3.94220883504775	0.136381174955373	0.486234961319748	20:9986125-10058303:+	ANKEF1	1;GO:0005509,molecular_function calcium ion binding	NA	ankyrin repeat and EF-hand domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:15803]
ENSG00000129353	40.14	39.44	41.70	38.43	38.26	37.92	0.0943735846864216	6.4818185538501	0.136430428516936	0.486234961319748	19:10602456-10644559:+	SLC44A2	15;GO:0004871,molecular_function signal transducer activity;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0015220,molecular_function choline transmembrane transporter activity;GO:0015871,biological_process choline transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043312,biological_process neutrophil degranulation;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	SLC44A2_4_5; solute carrier family 44 (choline transporter-like protein), member 2/4/5; K15377	solute carrier family 44 member 2 [Source:HGNC Symbol%3BAcc:HGNC:17292]
ENSG00000204356	67.37	69.59	70.97	76.60	71.38	76.24	-0.0976353269094337	6.50509874487459	0.136434090894762	0.486234961319748	6:31952086-31959110:-	NELFE	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008150,biological_process biological_process;GO:0016604,cellular_component nuclear body;GO:0032021,cellular_component NELF complex;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050434,biological_process positive regulation of viral transcription;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:1900364,biological_process negative regulation of mRNA polyadenylation	NA	negative elongation factor complex member E [Source:HGNC Symbol%3BAcc:HGNC:13974]
ENSG00000036448	0.16	0.30	0.20	0.37	0.22	0.35	-0.544525294363457	0.41177339330326	0.136568850437068	0.486432702413535	8:2045039-2165552:+	MYOM2	18;GO:0002074,biological_process extraocular skeletal muscle development;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005859,cellular_component muscle myosin complex;GO:0006936,biological_process muscle contraction;GO:0006941,biological_process striated muscle contraction;GO:0007015,biological_process actin filament organization;GO:0008307,molecular_function structural constituent of muscle;GO:0019900,molecular_function kinase binding;GO:0030018,cellular_component Z disc;GO:0031430,cellular_component M band;GO:0032982,cellular_component myosin filament;GO:0045214,biological_process sarcomere organization;GO:0051015,molecular_function actin filament binding;GO:0051371,molecular_function muscle alpha-actinin binding;GO:0071688,biological_process striated muscle myosin thick filament assembly;GO:0097493,molecular_function structural molecule activity conferring elasticity	NA	myomesin 2 [Source:HGNC Symbol%3BAcc:HGNC:7614]
ENSG00000117226	35.73	31.79	38.29	39.51	35.07	41.63	-0.120981140199203	6.23001957850988	0.13661441803617	0.486432702413535	1:89006665-89022894:-	GBP3	12;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051607,biological_process defense response to virus	NA	guanylate binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:4184]
ENSG00000164151	17.69	17.05	16.79	17.77	18.73	18.96	-0.0937784682048139	6.92454518751492	0.13661848408112	0.486432702413535	5:5420663-5490234:+	ICE1	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008023,cellular_component transcription elongation factor complex;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0035327,cellular_component transcriptionally active chromatin;GO:0035363,cellular_component histone locus body;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042796,biological_process snRNA transcription from RNA polymerase III promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0090316,biological_process positive regulation of intracellular protein transport	NA	interactor of little elongation complex ELL subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:29154]
ENSG00000175216	52.67	56.80	50.94	55.42	60.55	57.17	-0.0989206240877539	8.42014001106367	0.136676315213504	0.486432702413535	11:46743047-46846308:-	CKAP5	31;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0000930,cellular_component gamma-tubulin complex;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0030951,biological_process establishment or maintenance of microtubule cytoskeleton polarity;GO:0035371,cellular_component microtubule plus-end;GO:0043234,cellular_component protein complex;GO:0045296,molecular_function cadherin binding;GO:0046785,biological_process microtubule polymerization;GO:0050658,biological_process RNA transport;GO:0051010,molecular_function microtubule plus-end binding;GO:0051298,biological_process centrosome duplication;GO:0051301,biological_process cell division;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	cytoskeleton associated protein 5 [Source:HGNC Symbol%3BAcc:HGNC:28959]
ENSG00000158427	8.31	6.75	8.23	6.61	5.80	4.14	0.521391687050621	0.355586541603557	0.136712389733943	0.486432702413535	X:103918895-103966712:+	TMSB15B	8;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization;GO:0030335,biological_process positive regulation of cell migration	NA	NA
ENSG00000101974	7.69	8.22	7.63	6.93	7.52	7.33	0.119637095367805	4.73532306891105	0.136724699808332	0.486432702413535	X:139726345-139945276:-	ATP11C	21;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002329,biological_process pre-B cell differentiation;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0034220,biological_process ion transmembrane transport;GO:0045332,biological_process phospholipid translocation;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0055037,cellular_component recycling endosome	NA	ATPase phospholipid transporting 11C [Source:HGNC Symbol%3BAcc:HGNC:13554]
ENSG00000143575	101.60	93.42	100.70	113.31	102.63	104.39	-0.101828887091662	6.59221323193768	0.136824911097075	0.486649748265899	1:154272510-154275875:+	HAX1	33;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0019966,molecular_function interleukin-1 binding;GO:0030027,cellular_component lamellipodium;GO:0030833,biological_process regulation of actin filament polymerization;GO:0030854,biological_process positive regulation of granulocyte differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031965,cellular_component nuclear membrane;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047485,molecular_function protein N-terminus binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0071345,biological_process cellular response to cytokine stimulus;GO:1903146,biological_process regulation of mitophagy;GO:1903214,biological_process regulation of protein targeting to mitochondrion;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization	NA	HCLS1 associated protein X-1 [Source:HGNC Symbol%3BAcc:HGNC:16915]
ENSG00000155975	13.36	15.61	16.20	14.33	12.47	14.31	0.143448109690624	4.6561396598707	0.136907234651172	0.486738716345084	8:17246570-17302427:+	VPS37A	21;GO:0000813,cellular_component ESCRT I complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043657,cellular_component host cell;GO:0075733,biological_process intracellular transport of virus	VPS37; ESCRT-I complex subunit VPS37; K12185	VPS37A%2C ESCRT-I subunit [Source:HGNC Symbol%3BAcc:HGNC:24928]
ENSG00000179841	0.77	1.12	0.86	0.58	0.53	0.77	0.520039225623706	0.173691160766732	0.136928349107954	0.486738716345084	14:64465498-64474503:+	AKAP5	17;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006605,biological_process protein targeting;GO:0007165,biological_process signal transduction;GO:0007268,biological_process chemical synaptic transmission;GO:0008179,molecular_function adenylate cyclase binding;GO:0010739,biological_process positive regulation of protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030346,molecular_function protein phosphatase 2B binding;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0035254,molecular_function glutamate receptor binding;GO:0051018,molecular_function protein kinase A binding;GO:0097110,molecular_function scaffold protein binding	NA	A-kinase anchoring protein 5 [Source:HGNC Symbol%3BAcc:HGNC:375]
ENSG00000105856	58.55	55.37	58.28	52.47	56.35	53.53	0.0980678646391272	6.51661238087595	0.137035720471028	0.486980932781812	7:107168960-107202529:+	HBP1	10;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007050,biological_process cell cycle arrest;GO:0016055,biological_process Wnt signaling pathway;GO:0016607,cellular_component nuclear speck	NA	HMG-box transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:23200]
ENSG00000005812	14.74	13.17	15.30	13.94	12.05	13.36	0.152914255320508	4.15856189846059	0.137143477302457	0.487224380010131	13:76992597-77027195:-	FBXL3	17;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031648,biological_process protein destabilization;GO:0042752,biological_process regulation of circadian rhythm;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0048511,biological_process rhythmic process	FBXL3; F-box and leucine-rich repeat protein 3; K10269	F-box and leucine rich repeat protein 3 [Source:HGNC Symbol%3BAcc:HGNC:13599]
ENSG00000048052	2.97	3.16	2.89	3.52	2.73	4.41	-0.234639908862362	3.52174844987183	0.137205430058448	0.48730500810172	7:18086948-19002416:+	HDAC9	37;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001975,biological_process response to amphetamine;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006954,biological_process inflammatory response;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0030182,biological_process neuron differentiation;GO:0030183,biological_process B cell differentiation;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0032869,biological_process cellular response to insulin stimulus;GO:0033558,molecular_function protein deacetylase activity;GO:0034983,biological_process peptidyl-lysine deacetylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0042113,biological_process B cell activation;GO:0042826,molecular_function histone deacetylase binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048742,biological_process regulation of skeletal muscle fiber development;GO:0051153,biological_process regulation of striated muscle cell differentiation;GO:0070491,molecular_function repressing transcription factor binding;GO:0070932,biological_process histone H3 deacetylation;GO:0070933,biological_process histone H4 deacetylation;GO:0090050,biological_process positive regulation of cell migration involved in sprouting angiogenesis	HDAC9; histone deacetylase 9 [EC:3.5.1.98]; K11409	histone deacetylase 9 [Source:HGNC Symbol%3BAcc:HGNC:14065]
ENSG00000205726	12.96	14.16	12.15	14.10	13.91	14.51	-0.106459300705179	6.24545902864575	0.137307210409508	0.487478034407387	21:33642399-33899861:+	ITSN1	37;GO:0004363,molecular_function glutathione synthase activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006750,biological_process glutathione biosynthetic process;GO:0006897,biological_process endocytosis;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019209,molecular_function kinase activator activity;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0032947,molecular_function protein complex scaffold;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0061024,biological_process membrane organization;GO:0070064,molecular_function proline-rich region binding	NA	intersectin 1 [Source:HGNC Symbol%3BAcc:HGNC:6183]
ENSG00000115840	8.71	9.15	9.08	8.23	8.64	7.83	0.135450751797974	4.28243890255503	0.137345583272101	0.487478034407387	2:171784369-171999859:-	SLC25A12	19;GO:0005313,molecular_function L-glutamate transmembrane transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006094,biological_process gluconeogenesis;GO:0006810,biological_process transport;GO:0015172,molecular_function acidic amino acid transmembrane transporter activity;GO:0015183,molecular_function L-aspartate transmembrane transporter activity;GO:0015810,biological_process aspartate transport;GO:0015813,biological_process L-glutamate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043209,cellular_component myelin sheath;GO:0043490,biological_process malate-aspartate shuttle;GO:0046872,molecular_function metal ion binding;GO:0051592,biological_process response to calcium ion;GO:0055085,biological_process transmembrane transport;GO:0089711,biological_process L-glutamate transmembrane transport;GO:0089712,biological_process L-aspartate transmembrane transport	NA	solute carrier family 25 member 12 [Source:HGNC Symbol%3BAcc:HGNC:10982]
ENSG00000130844	9.20	8.74	10.17	10.67	11.19	9.92	-0.158636799862238	3.81347112982535	0.137371962004112	0.487478034407387	19:53520980-53580269:+	ZNF331	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 331 [Source:HGNC Symbol%3BAcc:HGNC:15489]
ENSG00000177000	28.08	26.42	27.49	28.74	29.58	30.02	-0.0939897788442106	6.00001392321802	0.137597732901997	0.488074379948658	1:11785722-11806920:-	MTHFR	27;GO:0001666,biological_process response to hypoxia;GO:0003824,molecular_function catalytic activity;GO:0004489,molecular_function methylenetetrahydrofolate reductase (NAD(P)H) activity;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006555,biological_process methionine metabolic process;GO:0008015,biological_process blood circulation;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0031060,biological_process regulation of histone methylation;GO:0032403,molecular_function protein complex binding;GO:0033274,biological_process response to vitamin B2;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0042493,biological_process response to drug;GO:0043200,biological_process response to amino acid;GO:0045202,cellular_component synapse;GO:0046500,biological_process S-adenosylmethionine metabolic process;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046655,biological_process folic acid metabolic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050661,molecular_function NADP binding;GO:0050667,biological_process homocysteine metabolic process;GO:0051593,biological_process response to folic acid;GO:0055114,biological_process oxidation-reduction process;GO:0070555,biological_process response to interleukin-1;GO:0070829,biological_process heterochromatin maintenance;GO:0072341,molecular_function modified amino acid binding	metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]; K00297	methylenetetrahydrofolate reductase [Source:HGNC Symbol%3BAcc:HGNC:7436]
ENSG00000054965	14.76	18.41	16.89	12.68	16.27	14.99	0.191750095505892	3.53177572611333	0.137631220670685	0.488074379948658	11:73400486-73598189:-	FAM168A	2;GO:0005515,molecular_function protein binding;GO:1905053,biological_process positive regulation of base-excision repair	NA	family with sequence similarity 168 member A [Source:HGNC Symbol%3BAcc:HGNC:28999]
ENSG00000267680	16.25	15.27	14.61	13.03	14.62	15.05	0.123379957248523	4.98047523131844	0.137690884876728	0.488074379948658	19:44094338-44109886:+	ZNF224	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0017053,cellular_component transcriptional repressor complex;GO:0031965,cellular_component nuclear membrane;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 224 [Source:HGNC Symbol%3BAcc:HGNC:13017]
ENSG00000277726	8.83	8.49	8.82	9.13	5.80	7.41	0.23932783958325	2.99459739923611	0.137697291434802	0.488074379948658	1:11012661-11030528:+	AL109811.4	3;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding	NA	NA
ENSG00000133193	18.18	22.21	26.06	23.95	26.50	25.89	-0.189891461300727	3.94721094476497	0.137771869765154	0.488199320409607	17:73207352-73236753:-	FAM104A	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 104 member A [Source:HGNC Symbol%3BAcc:HGNC:25918]
ENSG00000015171	33.49	33.90	32.42	31.71	29.57	32.69	0.097306701834726	5.96867206500902	0.137831362369495	0.488270748028692	10:134464-254637:+	ZMYND11	28;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0034243,biological_process regulation of transcription elongation from RNA polymerase II promoter;GO:0035064,molecular_function methylated histone binding;GO:0042393,molecular_function histone binding;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	zinc finger MYND-type containing 11 [Source:HGNC Symbol%3BAcc:HGNC:16966]
ENSG00000020426	36.39	37.91	37.38	41.09	39.15	40.80	-0.106529986647457	5.21503783811586	0.137888415086875	0.488307256586548	14:60734741-60969953:+	MNAT1	39;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005675,cellular_component holo TFIIH complex;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006461,biological_process protein complex assembly;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007512,biological_process adult heart development;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0021591,biological_process ventricular system development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051592,biological_process response to calcium ion;GO:0061575,molecular_function cyclin-dependent protein serine/threonine kinase activator activity	MNAT1; CDK-activating kinase assembly factor MAT1; K10842	MNAT1%2C CDK activating kinase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:7181]
ENSG00000058668	81.55	79.72	80.19	84.29	88.69	85.44	-0.0860021313720883	8.33776640623667	0.137975172612707	0.488307256586548	1:203626560-203744081:+	ATP2B4	61;GO:0000166,molecular_function nucleotide binding;GO:0003407,biological_process neural retina development;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007283,biological_process spermatogenesis;GO:0010751,biological_process negative regulation of nitric oxide mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0017080,molecular_function sodium channel regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0021766,biological_process hippocampus development;GO:0030018,cellular_component Z disc;GO:0030165,molecular_function PDZ domain binding;GO:0030315,cellular_component T-tubule;GO:0030317,biological_process sperm motility;GO:0030346,molecular_function protein phosphatase 2B binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034220,biological_process ion transmembrane transport;GO:0036126,cellular_component sperm flagellum;GO:0036487,molecular_function nitric-oxide synthase inhibitor activity;GO:0042383,cellular_component sarcolemma;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0051001,biological_process negative regulation of nitric-oxide synthase activity;GO:0051599,biological_process response to hydrostatic pressure;GO:0070588,biological_process calcium ion transmembrane transport;GO:0070885,biological_process negative regulation of calcineurin-NFAT signaling cascade;GO:0071872,biological_process cellular response to epinephrine stimulus;GO:0097110,molecular_function scaffold protein binding;GO:0097228,cellular_component sperm principal piece;GO:0097553,biological_process calcium ion transmembrane import into cytosol;GO:0098703,biological_process calcium ion import across plasma membrane;GO:0098736,biological_process negative regulation of the force of heart contraction;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport;GO:1900082,biological_process negative regulation of arginine catabolic process;GO:1901205,biological_process negative regulation of adrenergic receptor signaling pathway involved in heart process;GO:1901660,biological_process calcium ion export;GO:1902083,biological_process negative regulation of peptidyl-cysteine S-nitrosylation;GO:1902305,biological_process regulation of sodium ion transmembrane transport;GO:1902806,biological_process regulation of cell cycle G1/S phase transition;GO:1903243,biological_process negative regulation of cardiac muscle hypertrophy in response to stress;GO:1903249,biological_process negative regulation of citrulline biosynthetic process;GO:1903779,biological_process regulation of cardiac conduction;GO:2000481,biological_process positive regulation of cAMP-dependent protein kinase activity	ATP2B; P-type Ca2+ transporter type 2B [EC:7.2.2.10]; K05850	ATPase plasma membrane Ca2+ transporting 4 [Source:HGNC Symbol%3BAcc:HGNC:817]
ENSG00000010404	14.56	14.44	14.06	13.57	12.84	13.62	0.116265054857163	4.74531197949045	0.138003911580162	0.488307256586548	X:149476989-149521096:-	IDS	10;GO:0003824,molecular_function catalytic activity;GO:0004423,molecular_function iduronate-2-sulfatase activity;GO:0005764,cellular_component lysosome;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0046872,molecular_function metal ion binding	IDS; iduronate 2-sulfatase [EC:3.1.6.13]; K01136	iduronate 2-sulfatase [Source:HGNC Symbol%3BAcc:HGNC:5389]
ENSG00000114125	102.47	103.79	99.24	109.55	108.79	110.81	-0.0972157561183538	5.69503782360366	0.138007484019944	0.488307256586548	3:141738203-141747560:+	RNF7	25;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0019788,molecular_function NEDD8 transferase activity;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0031466,cellular_component Cul5-RING ubiquitin ligase complex;GO:0031467,cellular_component Cul7-RING ubiquitin ligase complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043224,cellular_component nuclear SCF ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0046872,molecular_function metal ion binding;GO:0051775,biological_process response to redox state;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex;GO:0097602,molecular_function cullin family protein binding	RBX2, ROC2, RNF7; RING-box protein 2 [EC:2.3.2.32]; K10611	ring finger protein 7 [Source:HGNC Symbol%3BAcc:HGNC:10070]
ENSG00000151135	42.97	50.32	47.06	39.92	43.46	44.65	0.137064163679796	4.34507952050074	0.138038360054958	0.488307256586548	12:106955718-106978778:+	TMEM263	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 263 [Source:HGNC Symbol%3BAcc:HGNC:28281]
ENSG00000059378	15.58	13.97	18.24	20.16	15.35	18.51	-0.161699178440748	5.19005582476758	0.138236276080665	0.488766871218654	7:140023743-140063721:-	PARP12	6;GO:0003723,molecular_function RNA binding;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005634,cellular_component nucleus;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0046872,molecular_function metal ion binding	NA	poly(ADP-ribose) polymerase family member 12 [Source:HGNC Symbol%3BAcc:HGNC:21919]
ENSG00000275895	4.38	4.60	3.26	3.03	3.46	3.20	0.336529859005009	1.59324506851092	0.138283764091826	0.488766871218654	21:6484622-6499261:-	U2AF1L5	7;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding;GO:0089701,cellular_component U2AF	U2AF1; splicing factor U2AF 35 kDa subunit; K12836	U2 small nuclear RNA auxiliary factor 1 like 5 [Source:HGNC Symbol%3BAcc:HGNC:51830]
ENSG00000165802	23.63	25.54	24.40	22.62	22.87	23.40	0.103112638894481	5.30958658512392	0.138286413576083	0.488766871218654	9:137447572-137459334:-	NSMF	31;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005719,cellular_component nuclear euchromatin;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0030863,cellular_component cortical cytoskeleton;GO:0031965,cellular_component nuclear membrane;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043204,cellular_component perikaryon;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048168,biological_process regulation of neuronal synaptic plasticity;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071257,biological_process cellular response to electrical stimulus;GO:0071371,biological_process cellular response to gonadotropin stimulus;GO:0097440,cellular_component apical dendrite;GO:2001222,biological_process regulation of neuron migration;GO:2001224,biological_process positive regulation of neuron migration	NA	NMDA receptor synaptonuclear signaling and neuronal migration factor [Source:HGNC Symbol%3BAcc:HGNC:29843]
ENSG00000138395	18.03	13.84	15.71	18.83	14.57	21.65	-0.194635456645333	4.50642383801201	0.138346614823032	0.488840458240334	2:201790460-201895550:+	CDK15	15;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030332,molecular_function cyclin binding;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle	NA	cyclin dependent kinase 15 [Source:HGNC Symbol%3BAcc:HGNC:14434]
ENSG00000116863	35.09	27.91	31.97	35.41	32.87	36.68	-0.12648828662861	5.19252983068323	0.138402421479289	0.488898479744569	1:36088874-36093932:+	ADPRHL2	10;GO:0004649,molecular_function poly(ADP-ribose) glycohydrolase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0071451,biological_process cellular response to superoxide	NA	ADP-ribosylhydrolase like 2 [Source:HGNC Symbol%3BAcc:HGNC:21304]
ENSG00000243716	10.03	9.58	10.10	10.05	8.76	8.82	0.118609425469555	5.16638400287146	0.138456936693289	0.488941314733927	16:22479120-22536521:+	NPIPB5	3;GO:0005654,cellular_component nucleoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear pore complex interacting protein family member B5 [Source:HGNC Symbol%3BAcc:HGNC:37233]
ENSG00000126524	121.50	120.38	131.72	121.63	113.11	116.76	0.100623711502756	6.50748235307058	0.138493326561225	0.488941314733927	7:66987676-66995601:-	SBDS	22;GO:0000922,cellular_component spindle pole;GO:0001833,biological_process inner cell mass cell proliferation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006364,biological_process rRNA processing;GO:0007052,biological_process mitotic spindle organization;GO:0008017,molecular_function microtubule binding;GO:0008283,biological_process cell proliferation;GO:0019843,molecular_function rRNA binding;GO:0030282,biological_process bone mineralization;GO:0030595,biological_process leukocyte chemotaxis;GO:0042254,biological_process ribosome biogenesis;GO:0042256,biological_process mature ribosome assembly;GO:0043022,molecular_function ribosome binding;GO:0048539,biological_process bone marrow development	SDO1, SBDS; ribosome maturation protein SDO1; K14574	SBDS%2C ribosome maturation factor [Source:HGNC Symbol%3BAcc:HGNC:19440]
ENSG00000146733	129.37	122.36	123.23	135.55	133.86	134.06	-0.0931277447702955	6.60619309779516	0.138821282872803	0.489959790816065	7:56011050-56051604:-	PSPH	15;GO:0000287,molecular_function magnesium ion binding;GO:0004647,molecular_function phosphoserine phosphatase activity;GO:0005509,molecular_function calcium ion binding;GO:0005829,cellular_component cytosol;GO:0006563,biological_process L-serine metabolic process;GO:0006564,biological_process L-serine biosynthetic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009612,biological_process response to mechanical stimulus;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0031667,biological_process response to nutrient levels;GO:0033574,biological_process response to testosterone;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0046872,molecular_function metal ion binding	serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3]; K01079	phosphoserine phosphatase [Source:HGNC Symbol%3BAcc:HGNC:9577]
ENSG00000157978	11.92	10.96	13.86	11.83	10.51	10.12	0.198906440759166	3.43672950160237	0.138868301931294	0.489986421794528	1:25543579-25568886:+	LDLRAP1	40;GO:0001540,molecular_function beta-amyloid binding;GO:0001784,molecular_function phosphotyrosine binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005883,cellular_component neurofilament;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0009925,cellular_component basal plasma membrane;GO:0009967,biological_process positive regulation of signal transduction;GO:0030121,cellular_component AP-1 adaptor complex;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030276,molecular_function clathrin binding;GO:0030424,cellular_component axon;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031623,biological_process receptor internalization;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035591,molecular_function signaling adaptor activity;GO:0035612,molecular_function AP-2 adaptor complex binding;GO:0035615,molecular_function clathrin adaptor activity;GO:0042632,biological_process cholesterol homeostasis;GO:0042982,biological_process amyloid precursor protein metabolic process;GO:0043393,biological_process regulation of protein binding;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:0090003,biological_process regulation of establishment of protein localization to plasma membrane;GO:0090118,biological_process receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport;GO:0090205,biological_process positive regulation of cholesterol metabolic process;GO:1905602,biological_process positive regulation of receptor-mediated endocytosis involved in cholesterol transport	LDLRAP1, ARH; low density lipoprotein receptor adapter protein 1; K12474	low density lipoprotein receptor adaptor protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18640]
ENSG00000095752	4.02	1.60	4.19	3.01	1.27	2.71	0.52804584483594	0.895139998466993	0.138985600092418	0.490260941729806	19:55364388-55370463:-	IL11	17;GO:0005125,molecular_function cytokine activity;GO:0005142,molecular_function interleukin-11 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0007267,biological_process cell-cell signaling;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0030183,biological_process B cell differentiation;GO:0030219,biological_process megakaryocyte differentiation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045444,biological_process fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046888,biological_process negative regulation of hormone secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation	IL11; interleukin 11; K05417	interleukin 11 [Source:HGNC Symbol%3BAcc:HGNC:5966]
ENSG00000134086	42.44	39.93	42.04	46.05	41.19	50.18	-0.130575854167147	4.81291861965663	0.139125180043911	0.490613880649166	3:10141007-10152220:+	VHL	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000902,biological_process cell morphogenesis;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0019899,molecular_function enzyme binding;GO:0030891,cellular_component VCB complex;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0050821,biological_process protein stabilization;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061428,biological_process negative regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061630,molecular_function ubiquitin protein ligase activity	VHL; von Hippel-Lindau disease tumor supressor; K03871	von Hippel-Lindau tumor suppressor [Source:HGNC Symbol%3BAcc:HGNC:12687]
ENSG00000172345	3.03	3.65	2.99	2.68	2.53	2.43	0.335293787306436	1.34952726664709	0.139241318883955	0.490686142955683	15:81309052-81324183:-	STARD5	10;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0015485,molecular_function cholesterol binding;GO:0015721,biological_process bile acid and bile salt transport;GO:0017127,molecular_function cholesterol transporter activity;GO:0032052,molecular_function bile acid binding;GO:0070508,biological_process cholesterol import	NA	StAR related lipid transfer domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:18065]
ENSG00000164074	11.73	11.52	12.28	13.01	12.38	14.04	-0.138502832154696	4.17201250519769	0.139245601715716	0.490686142955683	4:127965305-128039711:+	ABHD18	1;GO:0005576,cellular_component extracellular region	NA	abhydrolase domain containing 18 [Source:HGNC Symbol%3BAcc:HGNC:26111]
ENSG00000100221	68.88	68.84	72.03	77.58	71.48	78.41	-0.10507073824421	5.47629738973065	0.139264261792707	0.490686142955683	22:38685542-38701556:-	JOSD1	11;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	Josephin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28953]
ENSG00000165716	0.87	1.48	1.37	0.64	1.41	0.49	0.553866229903536	0.556848598984519	0.139502546298201	0.491256875236723	9:136712569-136724050:+	FAM69B	5;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 69 member B [Source:HGNC Symbol%3BAcc:HGNC:28290]
ENSG00000101846	1.29	2.40	2.02	2.48	2.21	2.49	-0.344575654867497	1.96051083758414	0.139505396375529	0.491256875236723	X:7219455-7354810:+	STS	23;GO:0003824,molecular_function catalytic activity;GO:0004773,molecular_function steryl-sulfatase activity;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006706,biological_process steroid catabolic process;GO:0007565,biological_process female pregnancy;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	STS; steryl-sulfatase [EC:3.1.6.2]; K01131	steroid sulfatase [Source:HGNC Symbol%3BAcc:HGNC:11425]
ENSG00000089041	1.98	1.09	1.95	2.29	1.54	2.81	-0.371865190229047	1.98806309134696	0.139570239211472	0.491345825108338	12:121132818-121188032:+	P2RX7	113;GO:0000187,biological_process activation of MAPK activity;GO:0000902,biological_process cell morphogenesis;GO:0001530,molecular_function lipopolysaccharide binding;GO:0001614,molecular_function purinergic nucleotide receptor activity;GO:0001845,biological_process phagolysosome assembly;GO:0001916,biological_process positive regulation of T cell mediated cytotoxicity;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002028,biological_process regulation of sodium ion transport;GO:0004872,molecular_function receptor activity;GO:0004931,molecular_function extracellular ATP-gated cation channel activity;GO:0005102,molecular_function receptor binding;GO:0005216,molecular_function ion channel activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006468,biological_process protein phosphorylation;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0006649,biological_process phospholipid transfer to membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0006884,biological_process cell volume homeostasis;GO:0006900,biological_process membrane budding;GO:0006954,biological_process inflammatory response;GO:0007005,biological_process mitochondrion organization;GO:0007009,biological_process plasma membrane organization;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007596,biological_process blood coagulation;GO:0009612,biological_process response to mechanical stimulus;GO:0009617,biological_process response to bacterium;GO:0009897,cellular_component external side of plasma membrane;GO:0010033,biological_process response to organic substance;GO:0010043,biological_process response to zinc ion;GO:0010467,biological_process gene expression;GO:0010524,biological_process positive regulation of calcium ion transport into cytosol;GO:0010628,biological_process positive regulation of gene expression;GO:0012501,biological_process programmed cell death;GO:0014049,biological_process positive regulation of glutamate secretion;GO:0014054,biological_process positive regulation of gamma-aminobutyric acid secretion;GO:0014070,biological_process response to organic cyclic compound;GO:0015267,molecular_function channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016485,biological_process protein processing;GO:0017121,biological_process phospholipid scrambling;GO:0019233,biological_process sensory perception of pain;GO:0019835,biological_process cytolysis;GO:0030501,biological_process positive regulation of bone mineralization;GO:0031594,cellular_component neuromuscular junction;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032059,cellular_component bleb;GO:0032060,biological_process bleb assembly;GO:0032308,biological_process positive regulation of prostaglandin secretion;GO:0032496,biological_process response to lipopolysaccharide;GO:0032731,biological_process positive regulation of interleukin-1 beta production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032963,biological_process collagen metabolic process;GO:0033198,biological_process response to ATP;GO:0034405,biological_process response to fluid shear stress;GO:0034767,biological_process positive regulation of ion transmembrane transport;GO:0035590,biological_process purinergic nucleotide receptor signaling pathway;GO:0042098,biological_process T cell proliferation;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0043029,biological_process T cell homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043132,biological_process NAD transport;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0044254,biological_process multicellular organismal protein catabolic process;GO:0045202,cellular_component synapse;GO:0045332,biological_process phospholipid translocation;GO:0045778,biological_process positive regulation of ossification;GO:0045779,biological_process negative regulation of bone resorption;GO:0045794,biological_process negative regulation of cell volume;GO:0045821,biological_process positive regulation of glycolytic process;GO:0045919,biological_process positive regulation of cytolysis;GO:0046513,biological_process ceramide biosynthetic process;GO:0046931,biological_process pore complex assembly;GO:0048705,biological_process skeletal system morphogenesis;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050714,biological_process positive regulation of protein secretion;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050717,biological_process positive regulation of interleukin-1 alpha secretion;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051259,biological_process protein oligomerization;GO:0051495,biological_process positive regulation of cytoskeleton organization;GO:0051592,biological_process response to calcium ion;GO:0051602,biological_process response to electrical stimulus;GO:0051709,biological_process regulation of killing of cells of other organism;GO:0051899,biological_process membrane depolarization;GO:0051901,biological_process positive regulation of mitochondrial depolarization;GO:0060079,biological_process excitatory postsynaptic potential;GO:0070230,biological_process positive regulation of lymphocyte apoptotic process;GO:0071359,biological_process cellular response to dsRNA;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0098655,biological_process cation transmembrane transport;GO:0098793,cellular_component presynapse;GO:0098794,cellular_component postsynapse;GO:1904172,biological_process positive regulation of bleb assembly	P2RX7; P2X purinoceptor 7; K05220	purinergic receptor P2X 7 [Source:HGNC Symbol%3BAcc:HGNC:8537]
ENSG00000009413	5.13	4.93	5.69	5.88	5.74	5.52	-0.106720888856467	5.73525583798141	0.139610836680854	0.49134939487367	6:111299027-111483715:-	REV3L	21;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0016035,cellular_component zeta DNA polymerase complex;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0042276,biological_process error-prone translesion synthesis;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	REV3L, POLZ; DNA polymerase zeta [EC:2.7.7.7]; K02350	REV3 like%2C DNA directed polymerase zeta catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9968]
ENSG00000008083	6.42	5.65	7.23	7.57	6.55	7.49	-0.145438720757509	4.68622734888623	0.139717848975748	0.491452124093687	6:15246295-15522040:+	JARID2	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001889,biological_process liver development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010614,biological_process negative regulation of cardiac muscle hypertrophy;GO:0016569,biological_process covalent chromatin modification;GO:0030154,biological_process cell differentiation;GO:0031061,biological_process negative regulation of histone methylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0035098,cellular_component ESC/E(Z) complex;GO:0042127,biological_process regulation of cell proliferation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0048863,biological_process stem cell differentiation;GO:0051574,biological_process positive regulation of histone H3-K9 methylation;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:1990830,biological_process cellular response to leukemia inhibitory factor	JARID2, JMJ; protein Jumonji; K11478	jumonji and AT-rich interaction domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:6196]
ENSG00000187186	10.51	7.30	7.87	5.43	5.79	8.32	0.41338984404713	1.09737202154898	0.139719209371354	0.491452124093687	9:34664162-34666112:-	AL162231.1	NA	CCL27; C-C motif chemokine 27; K16598	NA
ENSG00000143294	49.15	48.91	47.14	45.86	45.05	46.39	0.0919625607864327	6.21046850636772	0.139771853011875	0.491481472710596	1:156750609-156800817:+	PRCC	7;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0016607,cellular_component nuclear speck	PRCC; proline-rich protein PRCC; K13105	papillary renal cell carcinoma (translocation-associated) [Source:HGNC Symbol%3BAcc:HGNC:9343]
ENSG00000164465	6.15	6.23	6.41	6.63	4.77	5.17	0.193763159514693	3.67729202223489	0.139806741330953	0.491481472710596	6:117453816-117569858:+	DCBLD1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070492,molecular_function oligosaccharide binding	NA	discoidin%2C CUB and LCCL domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21479]
ENSG00000077684	25.83	25.59	26.20	27.71	27.71	27.98	-0.0914213970814093	6.10170616050173	0.14001513242801	0.492050865645571	4:128809622-128875224:+	JADE1	24;GO:0000123,cellular_component histone acetyltransferase complex;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0030308,biological_process negative regulation of cell growth;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043966,biological_process histone H3 acetylation;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043983,biological_process histone H4-K12 acetylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	jade family PHD finger 1 [Source:HGNC Symbol%3BAcc:HGNC:30027]
ENSG00000139546	14.60	16.21	14.10	14.91	12.93	12.76	0.151708568330501	4.08650601084542	0.140081699283619	0.492050865645571	12:53500920-53506431:+	TARBP2	36;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007286,biological_process spermatid development;GO:0007338,biological_process single fertilization;GO:0010586,biological_process miRNA metabolic process;GO:0016442,cellular_component RISC complex;GO:0016604,cellular_component nuclear body;GO:0019899,molecular_function enzyme binding;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0030423,biological_process targeting of mRNA for destruction involved in RNA interference;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035087,biological_process siRNA loading onto RISC involved in RNA interference;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0035197,molecular_function siRNA binding;GO:0035264,biological_process multicellular organism growth;GO:0035280,biological_process miRNA loading onto RISC involved in gene silencing by miRNA;GO:0036002,molecular_function pre-mRNA binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045727,biological_process positive regulation of translation;GO:0046782,biological_process regulation of viral transcription;GO:0047485,molecular_function protein N-terminus binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050689,biological_process negative regulation of defense response to virus by host;GO:0070578,cellular_component RISC-loading complex;GO:0070883,molecular_function pre-miRNA binding	NA	TARBP2%2C RISC loading complex RNA binding subunit [Source:HGNC Symbol%3BAcc:HGNC:11569]
ENSG00000174989	10.24	7.51	9.23	10.52	9.17	11.13	-0.171005426780529	4.13341358500021	0.140150300485322	0.492050865645571	12:116910955-117031148:+	FBXW8	17;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007030,biological_process Golgi organization;GO:0008283,biological_process cell proliferation;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031467,cellular_component Cul7-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0060712,biological_process spongiotrophoblast layer development;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:1990393,cellular_component 3M complex	FBXW8; F-box and WD-40 domain protein 8; K10264	F-box and WD repeat domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:13597]
ENSG00000060138	241.60	231.01	244.18	253.37	248.76	266.51	-0.0885640147143289	8.14637454745478	0.140192195776265	0.492050865645571	12:10699088-10723312:-	YBX3	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0005923,cellular_component bicellular tight junction;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007283,biological_process spermatogenesis;GO:0008584,biological_process male gonad development;GO:0009409,biological_process response to cold;GO:0009566,biological_process fertilization;GO:0017048,molecular_function Rho GTPase binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046622,biological_process positive regulation of organ growth;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048642,biological_process negative regulation of skeletal muscle tissue development;GO:0060546,biological_process negative regulation of necroptotic process;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071474,biological_process cellular hyperosmotic response;GO:1902219,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:2000767,biological_process positive regulation of cytoplasmic translation	CSDA, ZONAB; cold shock domain protein A; K06099	Y-box binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:2428]
ENSG00000111647	5.63	5.98	5.62	4.77	5.38	5.70	0.128824522527336	4.6575610384927	0.140203689382212	0.492050865645571	12:100028454-100142848:-	UHRF1BP1L	NA	NA	UHRF1 binding protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:29102]
ENSG00000175105	6.37	5.93	6.72	5.46	5.89	6.13	0.136484600787714	4.37667650957862	0.140206550534793	0.492050865645571	3:88059273-88144665:+	ZNF654	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 654 [Source:HGNC Symbol%3BAcc:HGNC:25612]
ENSG00000106948	4.73	3.38	5.78	5.85	4.75	5.75	-0.21468430839272	4.49379393931077	0.140328611639388	0.49225551528509	9:114334155-114394405:-	AKNA	14;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	AT-hook transcription factor [Source:HGNC Symbol%3BAcc:HGNC:24108]
ENSG00000099821	15.94	14.32	14.27	14.35	12.65	14.53	0.113358928260095	5.76276676483866	0.140345895796615	0.49225551528509	19:617223-633604:-	POLRMT	15;GO:0000997,molecular_function mitochondrial RNA polymerase core promoter sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006351,biological_process transcription, DNA-templated;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0006391,biological_process transcription initiation from mitochondrial promoter;GO:0007005,biological_process mitochondrion organization;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0034245,cellular_component mitochondrial DNA-directed RNA polymerase complex;GO:0042645,cellular_component mitochondrial nucleoid	NA	RNA polymerase mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:9200]
ENSG00000136197	18.23	16.83	15.62	16.15	19.84	20.85	-0.15374680832203	4.69812367305998	0.140383833409266	0.49225551528509	7:42908725-42912305:-	C7orf25	1;GO:0005515,molecular_function protein binding	NA	chromosome 7 open reading frame 25 [Source:HGNC Symbol%3BAcc:HGNC:21703]
ENSG00000125962	7.21	8.16	7.03	8.27	8.34	8.53	-0.163070934735353	3.74513934648453	0.140483205512273	0.492451700917435	X:102599167-102604159:+	ARMCX5	1;GO:0005515,molecular_function protein binding	NA	armadillo repeat containing%2C X-linked 5 [Source:HGNC Symbol%3BAcc:HGNC:25772]
ENSG00000121892	32.48	32.04	32.58	34.47	34.56	35.06	-0.0883031491707903	7.09556339806465	0.140519127096556	0.492451700917435	4:39822862-39977956:-	PDS5A	14;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0008156,biological_process negative regulation of DNA replication;GO:0051301,biological_process cell division	NA	PDS5 cohesin associated factor A [Source:HGNC Symbol%3BAcc:HGNC:29088]
ENSG00000156735	3.36	3.06	3.09	3.83	3.67	3.85	-0.238893193567257	2.3400696870045	0.140607815646651	0.492504893074419	8:38176532-38213301:+	BAG4	28;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0003723,molecular_function RNA binding;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045785,biological_process positive regulation of cell adhesion;GO:0051087,molecular_function chaperone binding;GO:0051291,biological_process protein heterooligomerization;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0072659,biological_process protein localization to plasma membrane;GO:0090367,biological_process negative regulation of mRNA modification;GO:0097178,biological_process ruffle assembly;GO:1900034,biological_process regulation of cellular response to heat;GO:1903215,biological_process negative regulation of protein targeting to mitochondrion;GO:2001145,biological_process negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	BAG4; BCL2-associated athanogene 4; K09558	BCL2 associated athanogene 4 [Source:HGNC Symbol%3BAcc:HGNC:940]
ENSG00000128524	192.34	214.32	198.27	194.90	198.81	169.50	0.113460191675035	6.42581128896025	0.140613658346551	0.492504893074419	7:128862825-128865844:+	ATP6V1F	19;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016469,cellular_component proton-transporting two-sector ATPase complex;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0033180,cellular_component proton-transporting V-type ATPase, V1 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0042624,molecular_function ATPase activity, uncoupled;GO:0042625,molecular_function ATPase coupled ion transmembrane transporter activity;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV1F, ATP6S14; V-type H+-transporting ATPase subunit F; K02151	ATPase H+ transporting V1 subunit F [Source:HGNC Symbol%3BAcc:HGNC:16832]
ENSG00000197993	0.38	0.34	0.36	0.44	0.65	0.54	-0.551225619458946	0.220406391591633	0.140671012868731	0.49256679343852	7:142941113-142962681:-	KEL	19;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008361,biological_process regulation of cell size;GO:0010961,biological_process cellular magnesium ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031133,biological_process regulation of axon diameter;GO:0042310,biological_process vasoconstriction;GO:0042552,biological_process myelination;GO:0046872,molecular_function metal ion binding;GO:0048741,biological_process skeletal muscle fiber development;GO:1901380,biological_process negative regulation of potassium ion transmembrane transport	NA	Kell blood group%2C metallo-endopeptidase [Source:HGNC Symbol%3BAcc:HGNC:6308]
ENSG00000121211	8.90	8.20	8.68	8.73	11.49	10.18	-0.220810297467212	2.84070610427926	0.140935043412843	0.493265530358099	4:153344648-153415118:+	MND1	7;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005634,cellular_component nucleus;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0007131,biological_process reciprocal meiotic recombination;GO:0051321,biological_process meiotic cell cycle	NA	meiotic nuclear divisions 1 [Source:HGNC Symbol%3BAcc:HGNC:24839]
ENSG00000185404	21.89	20.95	18.82	22.22	21.34	23.88	-0.119163165591224	5.24388618874425	0.140950039167017	0.493265530358099	2:230327183-230403732:+	SP140L	4;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0016604,cellular_component nuclear body;GO:0046872,molecular_function metal ion binding	NA	SP140 nuclear body protein like [Source:HGNC Symbol%3BAcc:HGNC:25105]
ENSG00000198862	8.38	9.24	8.62	7.68	8.33	8.52	0.105299368077805	5.5631875511182	0.140997362045395	0.49329206738148	21:28928143-28992956:-	LTN1	8;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	listerin E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:13082]
ENSG00000153048	119.67	141.31	134.78	143.98	154.12	134.33	-0.118547408804412	6.01649209934438	0.141230913883638	0.493748197185975	16:8852941-8869012:-	CARHSP1	15;GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0019902,molecular_function phosphatase binding;GO:0035556,biological_process intracellular signal transduction;GO:0043186,cellular_component P granule;GO:0043488,biological_process regulation of mRNA stability;GO:0070062,cellular_component extracellular exosome	NA	calcium regulated heat stable protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17150]
ENSG00000174939	35.68	38.96	35.42	36.35	40.51	43.45	-0.120760528937252	5.49462023219528	0.141302484601107	0.493748197185975	16:29900374-29919864:+	ASPHD1	6;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0018193,biological_process peptidyl-amino acid modification;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	aspartate beta-hydroxylase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:27380]
ENSG00000131061	1.60	1.79	1.44	1.34	1.45	1.21	0.272389488849076	1.96095838837773	0.141325410275067	0.493748197185975	20:33731656-33792269:+	ZNF341	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 341 [Source:HGNC Symbol%3BAcc:HGNC:15992]
ENSG00000158195	87.36	81.88	90.10	95.52	87.57	97.19	-0.0992139620780206	7.07330212659773	0.141341872198136	0.493748197185975	1:27404225-27490158:-	WASF2	32;GO:0001525,biological_process angiogenesis;GO:0001667,biological_process ameboidal-type cell migration;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0006897,biological_process endocytosis;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0015629,cellular_component actin cytoskeleton;GO:0016032,biological_process viral process;GO:0016601,biological_process Rac protein signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030048,biological_process actin filament-based movement;GO:0031209,cellular_component SCAR complex;GO:0032403,molecular_function protein complex binding;GO:0035855,biological_process megakaryocyte development;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0070062,cellular_component extracellular exosome;GO:0072673,biological_process lamellipodium morphogenesis	WASF2; WAS protein family, member 2; K05748	WAS protein family member 2 [Source:HGNC Symbol%3BAcc:HGNC:12733]
ENSG00000119950	30.89	22.84	26.89	31.50	26.52	33.32	-0.162166318307068	4.79465128111602	0.141378938644381	0.493748197185975	10:110207604-110287365:+	MXI1	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008285,biological_process negative regulation of cell proliferation;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0046983,molecular_function protein dimerization activity;GO:0090575,cellular_component RNA polymerase II transcription factor complex	NA	MAX interactor 1%2C dimerization protein [Source:HGNC Symbol%3BAcc:HGNC:7534]
ENSG00000136943	21.36	21.65	20.71	21.97	22.40	26.25	-0.139718801606156	4.49971464272243	0.141406657301011	0.493748197185975	9:97029678-97039643:-	CTSV	42;GO:0004177,molecular_function aminopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005773,cellular_component vacuole;GO:0005902,cellular_component microvillus;GO:0006508,biological_process proteolysis;GO:0007154,biological_process cell communication;GO:0007283,biological_process spermatogenesis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008584,biological_process male gonad development;GO:0009267,biological_process cellular response to starvation;GO:0009749,biological_process response to glucose;GO:0009897,cellular_component external side of plasma membrane;GO:0010259,biological_process multicellular organism aging;GO:0014070,biological_process response to organic cyclic compound;GO:0016787,molecular_function hydrolase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0021675,biological_process nerve development;GO:0022617,biological_process extracellular matrix disassembly;GO:0030141,cellular_component secretory granule;GO:0030984,molecular_function kininogen binding;GO:0032403,molecular_function protein complex binding;GO:0034698,biological_process response to gonadotropin;GO:0042277,molecular_function peptide binding;GO:0043005,cellular_component neuron projection;GO:0043202,cellular_component lysosomal lumen;GO:0043204,cellular_component perikaryon;GO:0045177,cellular_component apical part of cell;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0046697,biological_process decidualization;GO:0048102,biological_process autophagic cell death;GO:0051384,biological_process response to glucocorticoid;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0060008,biological_process Sertoli cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:1990834,biological_process response to odorant	CTSL2, CTSV; cathepsin V [EC:3.4.22.43]; K01375	cathepsin V [Source:HGNC Symbol%3BAcc:HGNC:2538]
ENSG00000205307	1.51	2.15	2.31	1.09	1.87	1.34	0.470249399304085	0.731626733748828	0.141458544722662	0.493748197185975	7:100572227-100573820:-	SAP25	4;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	Sin3A associated protein 25 [Source:HGNC Symbol%3BAcc:HGNC:41908]
ENSG00000106615	331.09	308.17	310.36	300.42	299.94	299.81	0.0894429663073944	7.62880579254897	0.141484302172165	0.493748197185975	7:151466011-151520120:-	RHEB	25;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0019003,molecular_function GDP binding;GO:0019901,molecular_function protein kinase binding;GO:0032006,biological_process regulation of TOR signaling;GO:0032008,biological_process positive regulation of TOR signaling;GO:0046872,molecular_function metal ion binding;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0070062,cellular_component extracellular exosome;GO:2000074,biological_process regulation of type B pancreatic cell development	RHEB; Ras homolog enriched in brain; K07208	Ras homolog enriched in brain [Source:HGNC Symbol%3BAcc:HGNC:10011]
ENSG00000196814	0.71	0.77	1.18	0.98	1.30	1.63	-0.530313767992964	0.325879405528119	0.141509568152244	0.493748197185975	9:126326848-126507041:+	MVB12B	24;GO:0000813,cellular_component ESCRT I complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0019058,biological_process viral life cycle;GO:0019075,biological_process virus maturation;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0042058,biological_process regulation of epidermal growth factor receptor signaling pathway;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043657,cellular_component host cell;GO:0048524,biological_process positive regulation of viral process;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus	FAM125; ESCRT-I complex subunit MVB12; K12186	multivesicular body subunit 12B [Source:HGNC Symbol%3BAcc:HGNC:23368]
ENSG00000135899	18.85	18.99	18.05	20.02	20.90	19.60	-0.103478773154999	5.43070439794648	0.141589826694952	0.493748197185975	2:230167292-230225729:-	SP110	8;GO:0003677,molecular_function DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0016032,biological_process viral process;GO:0046872,molecular_function metal ion binding	NA	SP110 nuclear body protein [Source:HGNC Symbol%3BAcc:HGNC:5401]
ENSG00000107185	15.90	16.70	16.75	19.21	18.30	17.08	-0.134645299167928	4.35653800949521	0.141629460843689	0.493748197185975	9:35749286-35758575:+	RGP1	16;GO:0000139,cellular_component Golgi membrane;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034066,cellular_component RIC1-RGP1 guanyl-nucleotide exchange factor complex;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization;GO:1903363,biological_process negative regulation of cellular protein catabolic process	NA	RGP1 homolog%2C RAB6A GEF complex partner 1 [Source:HGNC Symbol%3BAcc:HGNC:21965]
ENSG00000111581	23.37	23.90	21.58	22.94	24.70	27.36	-0.113354388185582	6.07658536968779	0.141638995805884	0.493748197185975	12:68686733-68745809:+	NUP107	37;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000973,biological_process posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008585,biological_process female gonad development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031080,cellular_component nuclear pore outer ring;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0051292,biological_process nuclear pore complex assembly;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP107, NUP84; nuclear pore complex protein Nup107; K14301	nucleoporin 107 [Source:HGNC Symbol%3BAcc:HGNC:29914]
ENSG00000003509	17.67	15.46	16.75	16.07	14.27	15.52	0.137790498305545	4.41285650238265	0.141644834462197	0.493748197185975	2:37231630-37253403:+	NDUFAF7	12;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0019918,biological_process peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0032259,biological_process methylation;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035243,molecular_function protein-arginine omega-N symmetric methyltransferase activity;GO:0046034,biological_process ATP metabolic process	NA	NADH:ubiquinone oxidoreductase complex assembly factor 7 [Source:HGNC Symbol%3BAcc:HGNC:28816]
ENSG00000213799	3.98	4.47	3.90	4.30	4.90	4.71	-0.168646750868378	3.68658729097749	0.141720749644032	0.493874134006561	19:53333748-53354869:+	ZNF845	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 845 [Source:HGNC Symbol%3BAcc:HGNC:25112]
ENSG00000204514	4.32	3.83	4.33	3.94	3.84	3.44	0.173910817242146	3.60702071974293	0.14193831717368	0.494493497355289	19:57848730-57889074:-	ZNF814	5;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 814 [Source:HGNC Symbol%3BAcc:HGNC:33258]
ENSG00000125449	11.75	16.19	16.40	16.35	18.03	17.03	-0.209948333815948	3.4432946736174	0.142032773975437	0.494683732692632	17:75109951-75130265:+	ARMC7	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016342,cellular_component catenin complex;GO:0019903,molecular_function protein phosphatase binding;GO:0045294,molecular_function alpha-catenin binding;GO:0045296,molecular_function cadherin binding	NA	armadillo repeat containing 7 [Source:HGNC Symbol%3BAcc:HGNC:26168]
ENSG00000147872	1044.26	986.08	1112.00	1158.35	1068.34	1160.52	-0.0963676715274172	10.5752188832532	0.142072626041185	0.494683732692632	9:19108374-19149290:-	PLIN2	13;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0014070,biological_process response to organic cyclic compound;GO:0015909,biological_process long-chain fatty acid transport;GO:0016020,cellular_component membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019915,biological_process lipid storage;GO:0042493,biological_process response to drug	PLIN2, ADRP; perilipin-2; K17284	perilipin 2 [Source:HGNC Symbol%3BAcc:HGNC:248]
ENSG00000078747	32.51	28.57	32.01	32.81	32.28	35.98	-0.104512017648056	6.45882587002459	0.142216098044329	0.495044426535126	20:34363234-34511393:+	ITCH	45;GO:0000209,biological_process protein polyubiquitination;GO:0001558,biological_process regulation of cell growth;GO:0002376,biological_process immune system process;GO:0002669,biological_process positive regulation of T cell anergy;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007219,biological_process Notch signaling pathway;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0035519,biological_process protein K29-linked ubiquitination;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045087,biological_process innate immune response;GO:0045236,molecular_function CXCR chemokine receptor binding;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046642,biological_process negative regulation of alpha-beta T cell proliferation;GO:0046718,biological_process viral entry into host cell;GO:0050687,biological_process negative regulation of defense response to virus;GO:0051607,biological_process defense response to virus;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0090085,biological_process regulation of protein deubiquitination;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	ITCH, AIP4; E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]; K05632	itchy E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:13890]
ENSG00000160226	15.09	15.33	13.70	12.48	14.99	12.28	0.161062288704653	3.98975436904549	0.14244372794353	0.495665689718266	21:44328943-44339402:-	C21orf2	14;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007224,biological_process smoothened signaling pathway;GO:0008360,biological_process regulation of cell shape;GO:0030030,biological_process cell projection organization;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	chromosome 21 open reading frame 2 [Source:HGNC Symbol%3BAcc:HGNC:1260]
ENSG00000175782	6.29	5.13	5.89	5.56	4.94	4.53	0.22809860985417	2.7439727410439	0.142474436551581	0.495665689718266	12:68746105-68793964:+	SLC35E3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member E3 [Source:HGNC Symbol%3BAcc:HGNC:20864]
ENSG00000164741	7.18	6.28	7.48	6.95	5.87	6.50	0.133153376277468	5.07113034164502	0.142731135249721	0.496419608252951	8:13083360-13604610:-	DLC1	34;GO:0001843,biological_process neural tube closure;GO:0003007,biological_process heart morphogenesis;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005901,cellular_component caveola;GO:0005925,cellular_component focal adhesion;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0021575,biological_process hindbrain morphogenesis;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030336,biological_process negative regulation of cell migration;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0030900,biological_process forebrain development;GO:0032587,cellular_component ruffle membrane;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0042169,molecular_function SH2 domain binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048041,biological_process focal adhesion assembly;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:1900119,biological_process positive regulation of execution phase of apoptosis	NA	DLC1 Rho GTPase activating protein [Source:HGNC Symbol%3BAcc:HGNC:2897]
ENSG00000151640	12.88	10.53	12.35	11.48	9.46	11.43	0.161861958621614	4.30009768937686	0.142857204647924	0.49655790735038	10:132186899-132205776:+	DPYSL4	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007399,biological_process nervous system development;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0031005,molecular_function filamin binding;GO:0070997,biological_process neuron death;GO:0097485,biological_process neuron projection guidance	NA	dihydropyrimidinase like 4 [Source:HGNC Symbol%3BAcc:HGNC:3016]
ENSG00000125944	125.24	128.03	122.89	133.01	137.65	132.06	-0.0869814402155802	7.96235991833368	0.142910710729163	0.49655790735038	1:23303770-23344336:-	HNRNPR	24;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006397,biological_process mRNA processing;GO:0007623,biological_process circadian rhythm;GO:0008380,biological_process RNA splicing;GO:0016070,biological_process RNA metabolic process;GO:0019013,cellular_component viral nucleocapsid;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043679,cellular_component axon terminus;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0061157,biological_process mRNA destabilization;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	heterogeneous nuclear ribonucleoprotein R [Source:HGNC Symbol%3BAcc:HGNC:5047]
ENSG00000129472	23.87	22.12	23.28	25.77	25.28	26.04	-0.138423536163743	4.00031573707717	0.142968656439763	0.49655790735038	14:21459019-21476973:-	RAB2B	15;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0045921,biological_process positive regulation of exocytosis;GO:0070062,cellular_component extracellular exosome	NA	RAB2B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:20246]
ENSG00000079950	62.22	65.49	62.93	53.90	62.50	61.69	0.108043964855093	5.63621209861366	0.142971092703009	0.49655790735038	6:132445866-132513198:-	STX7	33;GO:0000149,molecular_function SNARE binding;GO:0001772,cellular_component immunological synapse;GO:0001916,biological_process positive regulation of T cell mediated cytotoxicity;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0006906,biological_process vesicle fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019869,molecular_function chloride channel inhibitor activity;GO:0019905,molecular_function syntaxin binding;GO:0030139,cellular_component endocytic vesicle;GO:0031201,cellular_component SNARE complex;GO:0031901,cellular_component early endosome membrane;GO:0031982,cellular_component vesicle;GO:0042582,cellular_component azurophil granule;GO:0048278,biological_process vesicle docking;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051640,biological_process organelle localization;GO:0055037,cellular_component recycling endosome;GO:0065009,biological_process regulation of molecular function;GO:0070062,cellular_component extracellular exosome;GO:0070820,cellular_component tertiary granule;GO:0070925,biological_process organelle assembly;GO:1902685,biological_process positive regulation of receptor localization to synapse;GO:1903076,biological_process regulation of protein localization to plasma membrane	STX7; syntaxin 7; K08488	syntaxin 7 [Source:HGNC Symbol%3BAcc:HGNC:11442]
ENSG00000165092	443.91	585.66	431.91	361.21	537.66	380.88	0.203349006023781	9.42471730637164	0.143037691587491	0.49655790735038	9:72900661-73080442:-	ALDH1A1	19;GO:0000166,molecular_function nucleotide binding;GO:0001523,biological_process retinoid metabolic process;GO:0001758,molecular_function retinal dehydrogenase activity;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0005096,molecular_function GTPase activator activity;GO:0005497,molecular_function androgen binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006069,biological_process ethanol oxidation;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0018479,molecular_function benzaldehyde dehydrogenase (NAD+) activity;GO:0042572,biological_process retinol metabolic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0061624,biological_process fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0070062,cellular_component extracellular exosome	ALDH1A; retinal dehydrogenase [EC:1.2.1.36]; K07249	aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:402]
ENSG00000096872	12.40	12.44	12.37	11.52	12.02	10.93	0.122868870791668	4.57387659093038	0.143048303017554	0.49655790735038	9:26947038-27062930:+	IFT74	23;GO:0003334,biological_process keratinocyte development;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0007219,biological_process Notch signaling pathway;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008544,biological_process epidermis development;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031514,cellular_component motile cilium;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048487,molecular_function beta-tubulin binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip;GO:1905515,biological_process non-motile cilium assembly	NA	intraflagellar transport 74 [Source:HGNC Symbol%3BAcc:HGNC:21424]
ENSG00000140044	19.62	19.41	18.89	17.07	18.74	15.63	0.184805977574697	3.27036409866183	0.143105624549487	0.49655790735038	14:75427715-75474111:+	JDP2	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0031063,biological_process regulation of histone deacetylation;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0046982,molecular_function protein heterodimerization activity	NA	Jun dimerization protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17546]
ENSG00000101938	122.18	123.32	119.78	132.85	124.47	134.75	-0.0907838152658351	7.44043617055299	0.143163161398678	0.49655790735038	X:110673855-110795819:-	CHRDL1	12;GO:0001503,biological_process ossification;GO:0001654,biological_process eye development;GO:0005576,cellular_component extracellular region;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0030154,biological_process cell differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048749,biological_process compound eye development	NA	chordin like 1 [Source:HGNC Symbol%3BAcc:HGNC:29861]
ENSG00000141959	103.94	110.05	107.14	98.99	104.41	101.06	0.088235216105105	7.95735343964777	0.143177684153219	0.49655790735038	21:44300050-44327376:+	PFKL	34;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003872,molecular_function 6-phosphofructokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005945,cellular_component 6-phosphofructokinase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0006002,biological_process fructose 6-phosphate metabolic process;GO:0006096,biological_process glycolytic process;GO:0008152,biological_process metabolic process;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019900,molecular_function kinase binding;GO:0030388,biological_process fructose 1,6-bisphosphate metabolic process;GO:0034774,cellular_component secretory granule lumen;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046872,molecular_function metal ion binding;GO:0048029,molecular_function monosaccharide binding;GO:0051259,biological_process protein oligomerization;GO:0051289,biological_process protein homotetramerization;GO:0061615,biological_process glycolytic process through fructose-6-phosphate;GO:0061621,biological_process canonical glycolysis;GO:0070061,molecular_function fructose binding;GO:0070062,cellular_component extracellular exosome;GO:0070095,molecular_function fructose-6-phosphate binding;GO:1904813,cellular_component ficolin-1-rich granule lumen	pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]; K00850	phosphofructokinase%2C liver type [Source:HGNC Symbol%3BAcc:HGNC:8876]
ENSG00000163738	4.86	6.23	4.93	4.61	4.00	4.90	0.238940651140633	2.49063514356924	0.143185796138164	0.49655790735038	4:74114173-74303099:+	MTHFD2L	20;GO:0000105,biological_process histidine biosynthetic process;GO:0003824,molecular_function catalytic activity;GO:0004477,molecular_function methenyltetrahydrofolate cyclohydrolase activity;GO:0004487,molecular_function methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488,molecular_function methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006730,biological_process one-carbon metabolic process;GO:0008152,biological_process metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009086,biological_process methionine biosynthetic process;GO:0009256,biological_process 10-formyltetrahydrofolate metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016787,molecular_function hydrolase activity;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0046655,biological_process folic acid metabolic process;GO:0055114,biological_process oxidation-reduction process	MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]; K13403	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like [Source:HGNC Symbol%3BAcc:HGNC:31865]
ENSG00000103353	39.29	40.15	41.26	42.21	44.79	43.71	-0.103426908481373	5.29589809814621	0.143216528866772	0.49655790735038	16:23557361-23574389:+	UBFD1	2;GO:0003723,molecular_function RNA binding;GO:0045296,molecular_function cadherin binding	NA	ubiquitin family domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30565]
ENSG00000147155	83.01	94.73	72.32	72.81	81.12	75.72	0.130682253435501	5.78707690643097	0.143250935810981	0.49655790735038	X:48521157-48528716:+	EBP	29;GO:0000247,molecular_function C-8 sterol isomerase activity;GO:0001501,biological_process skeletal system development;GO:0004769,molecular_function steroid delta-isomerase activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006855,biological_process drug transmembrane transport;GO:0007165,biological_process signal transduction;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0015238,molecular_function drug transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016125,biological_process sterol metabolic process;GO:0016126,biological_process sterol biosynthetic process;GO:0016853,molecular_function isomerase activity;GO:0030097,biological_process hemopoiesis;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033489,biological_process cholesterol biosynthetic process via desmosterol;GO:0033490,biological_process cholesterol biosynthetic process via lathosterol;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0047750,molecular_function cholestenol delta-isomerase activity	EBP; cholestenol Delta-isomerase [EC:5.3.3.5]; K01824	emopamil binding protein (sterol isomerase) [Source:HGNC Symbol%3BAcc:HGNC:3133]
ENSG00000162772	7.29	5.39	6.65	8.82	6.48	8.51	-0.27409816866404	2.2185495473499	0.143347246711211	0.496654362772962	1:212565333-212620777:+	ATF3	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006094,biological_process gluconeogenesis;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0034198,biological_process cellular response to amino acid starvation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0061394,biological_process regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:1903984,biological_process positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:1990622,cellular_component CHOP-ATF3 complex	NA	activating transcription factor 3 [Source:HGNC Symbol%3BAcc:HGNC:785]
ENSG00000136715	12.52	13.61	13.09	13.82	14.54	14.06	-0.104471523815994	5.47205940828667	0.143358783679652	0.496654362772962	2:127941216-128028120:-	SAP130	6;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016607,cellular_component nuclear speck;GO:0070822,cellular_component Sin3-type complex	NA	Sin3A associated protein 130 [Source:HGNC Symbol%3BAcc:HGNC:29813]
ENSG00000087470	27.95	28.57	27.41	27.68	30.96	32.26	-0.104878094366546	6.08007586847804	0.143492273749993	0.496866908475962	12:32679199-32745650:+	DNM1L	80;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000266,biological_process mitochondrial fission;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0003374,biological_process dynamin polymerization involved in mitochondrial fission;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0005903,cellular_component brush border;GO:0005905,cellular_component clathrin-coated pit;GO:0006897,biological_process endocytosis;GO:0007005,biological_process mitochondrion organization;GO:0008017,molecular_function microtubule binding;GO:0008289,molecular_function lipid binding;GO:0010637,biological_process negative regulation of mitochondrial fusion;GO:0010821,biological_process regulation of mitochondrion organization;GO:0012501,biological_process programmed cell death;GO:0012505,cellular_component endomembrane system;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016559,biological_process peroxisome fission;GO:0016787,molecular_function hydrolase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030054,cellular_component cell junction;GO:0030276,molecular_function clathrin binding;GO:0030672,cellular_component synaptic vesicle membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032403,molecular_function protein complex binding;GO:0032459,biological_process regulation of protein oligomerization;GO:0036466,biological_process synaptic vesicle recycling via endosome;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0045202,cellular_component synapse;GO:0048312,biological_process intracellular distribution of mitochondria;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050714,biological_process positive regulation of protein secretion;GO:0051259,biological_process protein oligomerization;GO:0051260,biological_process protein homooligomerization;GO:0051289,biological_process protein homotetramerization;GO:0051433,molecular_function BH2 domain binding;GO:0060047,biological_process heart contraction;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0061025,biological_process membrane fusion;GO:0070266,biological_process necroptotic process;GO:0070584,biological_process mitochondrion morphogenesis;GO:0070585,biological_process protein localization to mitochondrion;GO:0071396,biological_process cellular response to lipid;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090149,biological_process mitochondrial membrane fission;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0090650,biological_process cellular response to oxygen-glucose deprivation;GO:0097194,biological_process execution phase of apoptosis;GO:0099073,cellular_component mitochondrion-derived vesicle;GO:0099503,cellular_component secretory vesicle;GO:1900063,biological_process regulation of peroxisome organization;GO:1900244,biological_process positive regulation of synaptic vesicle endocytosis;GO:1903146,biological_process regulation of mitophagy;GO:1903578,biological_process regulation of ATP metabolic process;GO:1904579,biological_process cellular response to thapsigargin;GO:1905395,biological_process response to flavonoid;GO:1990910,biological_process response to hypobaric hypoxia;GO:2000302,biological_process positive regulation of synaptic vesicle exocytosis;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	DNM1L; dynamin 1-like protein [EC:3.6.5.5]; K17065	dynamin 1 like [Source:HGNC Symbol%3BAcc:HGNC:2973]
ENSG00000196611	3.56	2.31	3.45	2.87	2.21	2.60	0.311558798190768	2.06194427364397	0.143500190678025	0.496866908475962	11:102789919-102798160:-	MMP1	18;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050900,biological_process leukocyte migration	MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]; K01388	matrix metallopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:7155]
ENSG00000138375	13.62	12.87	12.18	14.70	13.25	14.16	-0.111159322014745	5.30386190614243	0.143962921577902	0.498330101937115	2:216412413-216483053:+	SMARCAL1	17;GO:0000166,molecular_function nucleotide binding;GO:0000733,biological_process DNA strand renaturation;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0006259,biological_process DNA metabolic process;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0016787,molecular_function hydrolase activity;GO:0031297,biological_process replication fork processing;GO:0035861,cellular_component site of double-strand break;GO:0036310,molecular_function annealing helicase activity;GO:0090656,biological_process t-circle formation	NA	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a like 1 [Source:HGNC Symbol%3BAcc:HGNC:11102]
ENSG00000166503	48.93	42.43	45.00	42.18	37.87	45.65	0.132103438402604	4.91721344318009	0.144127309653409	0.498760048711394	15:83112737-83208018:-	HDGFL3	11;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0008017,molecular_function microtubule binding;GO:0008083,molecular_function growth factor activity;GO:0008283,biological_process cell proliferation;GO:0015631,molecular_function tubulin binding;GO:0031175,biological_process neuron projection development;GO:0046785,biological_process microtubule polymerization	NA	HDGF like 3 [Source:HGNC Symbol%3BAcc:HGNC:24937]
ENSG00000119509	5.80	6.16	6.62	7.38	6.70	6.52	-0.136772410716095	4.40864156944281	0.144336701504137	0.499345450326325	9:100099255-100301000:+	INVS	13;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0042995,cellular_component cell projection;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	inversin [Source:HGNC Symbol%3BAcc:HGNC:17870]
ENSG00000214021	16.08	14.45	16.96	14.76	13.12	16.07	0.125857079160309	5.57641335491528	0.144641907554348	0.500076563290527	3:9808085-9855138:+	TTLL3	18;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006464,biological_process cellular protein modification process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016874,molecular_function ligase activity;GO:0018094,biological_process protein polyglycylation;GO:0035082,biological_process axoneme assembly;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0070735,molecular_function protein-glycine ligase activity;GO:0070736,molecular_function protein-glycine ligase activity, initiating	NA	tubulin tyrosine ligase like 3 [Source:HGNC Symbol%3BAcc:HGNC:24483]
ENSG00000213859	14.41	11.12	13.54	14.95	16.35	13.94	-0.185301461475612	3.32040640465895	0.14470009099184	0.500076563290527	17:7351888-7354944:+	KCTD11	14;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007406,biological_process negative regulation of neuroblast proliferation;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0040008,biological_process regulation of growth;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:21302]
ENSG00000148153	17.15	21.54	20.42	22.50	22.80	23.17	-0.211505160819281	2.90726976800369	0.144714133111568	0.500076563290527	9:112683925-112718236:-	INIP	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010212,biological_process response to ionizing radiation;GO:0070876,cellular_component SOSS complex	NA	INTS3 and NABP interacting protein [Source:HGNC Symbol%3BAcc:HGNC:24994]
ENSG00000182923	19.03	15.86	16.26	18.95	19.02	18.11	-0.116323417291062	5.3092357633989	0.144760761202847	0.500076563290527	3:134485742-134575017:+	CEP63	19;GO:0000077,biological_process DNA damage checkpoint;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007099,biological_process centriole replication;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0098535,biological_process de novo centriole assembly	NA	centrosomal protein 63 [Source:HGNC Symbol%3BAcc:HGNC:25815]
ENSG00000256061	7.92	7.75	7.87	8.45	9.51	8.66	-0.163385872082171	3.52464338866984	0.144761261384705	0.500076563290527	15:55410524-55508234:-	DNAAF4	16;GO:0001764,biological_process neuron migration;GO:0003341,biological_process cilium movement;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007368,biological_process determination of left/right symmetry;GO:0007399,biological_process nervous system development;GO:0030331,molecular_function estrogen receptor binding;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0036158,biological_process outer dynein arm assembly;GO:0036159,biological_process inner dynein arm assembly;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0097730,cellular_component non-motile cilium	NA	dynein axonemal assembly factor 4 [Source:HGNC Symbol%3BAcc:HGNC:21493]
ENSG00000175110	35.06	35.89	37.36	42.23	37.95	37.51	-0.107811588579441	5.55275029488503	0.144789750138255	0.500076563290527	3:139005805-139357223:+	MRPS22	10;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0008150,biological_process biological_process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S22 [Source:HGNC Symbol%3BAcc:HGNC:14508]
ENSG00000144120	11.02	9.68	10.51	12.06	10.99	12.40	-0.165704553898481	3.48118936300659	0.144876027032354	0.500235361210738	2:119679166-119686507:+	TMEM177	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 177 [Source:HGNC Symbol%3BAcc:HGNC:28143]
ENSG00000134602	23.11	23.78	24.76	26.21	24.65	27.19	-0.112476752601784	5.04345677302026	0.144976652533927	0.500443600640611	X:132023264-132075943:+	STK26	39;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0009267,biological_process cellular response to starvation;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0030033,biological_process microvillus assembly;GO:0030336,biological_process negative regulation of cell migration;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048812,biological_process neuron projection morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071944,cellular_component cell periphery;GO:0097194,biological_process execution phase of apoptosis;GO:1903205,biological_process regulation of hydrogen peroxide-induced cell death	NA	serine/threonine kinase 26 [Source:HGNC Symbol%3BAcc:HGNC:18174]
ENSG00000204442	4.99	4.10	3.80	3.65	3.53	3.84	0.242593457146281	2.49461305355549	0.14502524428248	0.500472159376819	13:107163509-107866735:-	FAM155A	5;GO:0005886,cellular_component plasma membrane;GO:0015275,molecular_function stretch-activated, cation-selective, calcium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0098703,biological_process calcium ion import across plasma membrane	NA	family with sequence similarity 155 member A [Source:HGNC Symbol%3BAcc:HGNC:33877]
ENSG00000183977	13.33	13.38	13.21	15.30	15.18	13.39	-0.123265805647284	4.76008470873535	0.145192227575409	0.500836671437765	3:19979960-20012330:-	PP2D1	3;GO:0003824,molecular_function catalytic activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0006470,biological_process protein dephosphorylation	NA	protein phosphatase 2C like domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28406]
ENSG00000125967	16.77	15.59	16.81	14.60	15.59	15.26	0.129379478004506	4.38953555941112	0.145211566946308	0.500836671437765	20:33657086-33674463:-	NECAB3	12;GO:0000137,cellular_component Golgi cis cisterna;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0009306,biological_process protein secretion;GO:0019538,biological_process protein metabolic process;GO:0042984,biological_process regulation of amyloid precursor protein biosynthetic process;GO:0046872,molecular_function metal ion binding	NA	N-terminal EF-hand calcium binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:15851]
ENSG00000166734	46.06	42.01	44.17	41.90	42.15	40.75	0.098305741602072	5.81362766786459	0.145306798758334	0.501025914718668	15:44288728-44415758:+	CASC4	3;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	cancer susceptibility 4 [Source:HGNC Symbol%3BAcc:HGNC:24892]
ENSG00000173726	194.99	183.88	191.87	183.31	180.80	176.04	0.0928896087420079	6.33549227009491	0.145813691014298	0.502631583014559	1:235109335-235128936:-	TOMM20	24;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0006605,biological_process protein targeting;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0015450,molecular_function P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016031,biological_process tRNA import into mitochondrion;GO:0016236,biological_process macroautophagy;GO:0016579,biological_process protein deubiquitination;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0030943,molecular_function mitochondrion targeting sequence binding;GO:0031012,cellular_component extracellular matrix;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0051082,molecular_function unfolded protein binding;GO:0070096,biological_process mitochondrial outer membrane translocase complex assembly	NA	translocase of outer mitochondrial membrane 20 [Source:HGNC Symbol%3BAcc:HGNC:20947]
ENSG00000103067	0.19	0.31	0.37	0.48	0.24	0.64	-0.653313724011229	-0.0364784938892551	0.145888836539757	0.502631583014559	16:68229110-68238102:-	ESRP2	13;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0043484,biological_process regulation of RNA splicing;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060445,biological_process branching involved in salivary gland morphogenesis	NA	epithelial splicing regulatory protein 2 [Source:HGNC Symbol%3BAcc:HGNC:26152]
ENSG00000135272	22.03	22.15	19.75	18.68	20.62	19.55	0.128478678561483	4.52900918807689	0.145893949375772	0.502631583014559	7:114922153-115019202:+	MDFIC	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007257,biological_process activation of JUN kinase activity;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030332,molecular_function cyclin binding;GO:0030957,molecular_function Tat protein binding;GO:0042308,biological_process negative regulation of protein import into nucleus;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050434,biological_process positive regulation of viral transcription	NA	MyoD family inhibitor domain containing [Source:HGNC Symbol%3BAcc:HGNC:28870]
ENSG00000118454	21.24	20.02	21.22	24.45	20.93	22.92	-0.114681310759415	5.15367928261691	0.146157523524606	0.503262013795012	1:70260587-70354734:-	ANKRD13C	8;GO:0005102,molecular_function receptor binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006621,biological_process protein retention in ER lumen;GO:0010869,biological_process regulation of receptor biosynthetic process;GO:0016020,cellular_component membrane;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:2000209,biological_process regulation of anoikis	NA	ankyrin repeat domain 13C [Source:HGNC Symbol%3BAcc:HGNC:25374]
ENSG00000242802	18.17	18.75	18.45	15.22	17.45	18.76	0.116774314418475	5.4346966791362	0.146158024629906	0.503262013795012	7:4775621-4794312:+	AP5Z1	13;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006810,biological_process transport;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0015031,biological_process protein transport;GO:0016197,biological_process endosomal transport;GO:0016607,cellular_component nuclear speck;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0044599,cellular_component AP-5 adaptor complex	NA	adaptor related protein complex 5 zeta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:22197]
ENSG00000141905	32.51	28.20	30.70	28.00	28.13	29.63	0.107588516151222	5.58967949276537	0.146248051172933	0.503432351416978	19:3314402-3469217:+	NFIC	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001159,molecular_function core promoter proximal region DNA binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	nuclear factor I C [Source:HGNC Symbol%3BAcc:HGNC:7786]
ENSG00000118655	5.27	5.81	6.92	6.90	7.08	6.74	-0.190273138634165	3.38830779008296	0.1463645473974	0.503608006536215	1:113905140-113914086:+	DCLRE1B	31;GO:0000075,biological_process cell cycle checkpoint;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003684,molecular_function damaged DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0010833,biological_process telomere maintenance via telomere lengthening;GO:0016233,biological_process telomere capping;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0031627,biological_process telomeric loop formation;GO:0031848,biological_process protection from non-homologous end joining at telomere;GO:0031860,biological_process telomeric 3' overhang formation;GO:0035312,molecular_function 5'-3' exodeoxyribonuclease activity;GO:0036297,biological_process interstrand cross-link repair;GO:0042803,molecular_function protein homodimerization activity;GO:0044877,molecular_function macromolecular complex binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	DNA cross-link repair 1B [Source:HGNC Symbol%3BAcc:HGNC:17641]
ENSG00000183621	3.11	3.65	3.32	3.70	3.60	4.26	-0.196545912347733	3.24793845038173	0.14638022134719	0.503608006536215	10:30820206-31031937:-	ZNF438	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 438 [Source:HGNC Symbol%3BAcc:HGNC:21029]
ENSG00000114030	35.52	33.62	33.39	34.88	36.47	39.43	-0.0994725003523678	5.94643452554425	0.146421837913449	0.503611602665461	3:122421948-122514945:-	KPNA1	19;GO:0000018,biological_process regulation of DNA recombination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0019054,biological_process modulation by virus of host process;GO:0030425,cellular_component dendrite;GO:0043657,cellular_component host cell;GO:0075733,biological_process intracellular transport of virus	KPNA1_5_6; importin subunit alpha-5/6/7; K15042	karyopherin subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:6394]
ENSG00000173905	24.73	26.77	24.15	21.41	26.59	21.76	0.127209770153639	5.66382807958874	0.14649677035051	0.503710308870042	3:168008676-168095975:-	GOLIM4	12;GO:0000139,cellular_component Golgi membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0005801,cellular_component cis-Golgi network;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0030139,cellular_component endocytic vesicle;GO:0032580,cellular_component Golgi cisterna membrane	NA	golgi integral membrane protein 4 [Source:HGNC Symbol%3BAcc:HGNC:15448]
ENSG00000107854	14.98	15.30	15.32	14.66	13.57	14.71	0.0969935194390304	5.69458365810711	0.146576459861388	0.503710308870042	10:91798311-91865276:+	TNKS2	30;GO:0000139,cellular_component Golgi membrane;GO:0000209,biological_process protein polyubiquitination;GO:0000242,cellular_component pericentriolar material;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006471,biological_process protein ADP-ribosylation;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019899,molecular_function enzyme binding;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0035264,biological_process multicellular organism growth;GO:0040014,biological_process regulation of multicellular organism growth;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0070213,biological_process protein auto-ADP-ribosylation;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1904355,biological_process positive regulation of telomere capping;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening	NA	tankyrase 2 [Source:HGNC Symbol%3BAcc:HGNC:15677]
ENSG00000170899	11.45	7.61	8.73	8.21	6.83	8.34	0.27387611569911	2.55335440247411	0.146592687530193	0.503710308870042	6:52977947-52995378:-	GSTA4	11;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase alpha 4 [Source:HGNC Symbol%3BAcc:HGNC:4629]
ENSG00000164938	1.72	1.55	1.99	1.01	1.85	0.76	0.568418258175832	0.312319055466615	0.146612853133607	0.503710308870042	8:94925971-94949411:-	TP53INP1	36;GO:0000045,biological_process autophagosome assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0007050,biological_process cell cycle arrest;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009408,biological_process response to heat;GO:0010506,biological_process regulation of autophagy;GO:0010508,biological_process positive regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016209,molecular_function antioxidant activity;GO:0016605,cellular_component PML body;GO:0030336,biological_process negative regulation of cell migration;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034644,biological_process cellular response to UV;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048102,biological_process autophagic cell death;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0071361,biological_process cellular response to ethanol;GO:0071447,biological_process cellular response to hydroperoxide;GO:0072703,biological_process cellular response to methyl methanesulfonate;GO:0098869,biological_process cellular oxidant detoxification;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904761,biological_process negative regulation of myofibroblast differentiation;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	tumor protein p53 inducible nuclear protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18022]
ENSG00000106399	141.84	135.85	128.14	148.09	158.37	135.79	-0.111453927941797	5.68647435657416	0.1466891546163	0.503780040889163	7:7636517-7718607:-	RPA3	34;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0019985,biological_process translesion synthesis;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0036297,biological_process interstrand cross-link repair;GO:0042127,biological_process regulation of cell proliferation;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0070987,biological_process error-free translesion synthesis;GO:1900034,biological_process regulation of cellular response to heat;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RPA3; replication factor A3; K10740	replication protein A3 [Source:HGNC Symbol%3BAcc:HGNC:10291]
ENSG00000187838	22.29	25.43	26.66	23.07	22.73	22.65	0.128916230091077	4.67927064979633	0.146770354224557	0.503780040889163	17:7389726-7394843:-	PLSCR3	15;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017121,biological_process phospholipid scrambling;GO:0017124,molecular_function SH3 domain binding;GO:0017128,molecular_function phospholipid scramblase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0042593,biological_process glucose homeostasis;GO:0042632,biological_process cholesterol homeostasis;GO:0048306,molecular_function calcium-dependent protein binding;GO:0071222,biological_process cellular response to lipopolysaccharide	NA	phospholipid scramblase 3 [Source:HGNC Symbol%3BAcc:HGNC:16495]
ENSG00000205808	4.47	4.75	2.58	2.54	3.69	2.86	0.376852614648484	1.6763765796244	0.146812952472193	0.503780040889163	9:4662314-4665258:+	PLPP6	5;GO:0005886,cellular_component plasma membrane;GO:0006695,biological_process cholesterol biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity	NA	phospholipid phosphatase 6 [Source:HGNC Symbol%3BAcc:HGNC:23682]
ENSG00000232388	75.93	63.88	58.35	77.98	67.20	76.69	-0.149256356998815	4.76799667733649	0.146813975608054	0.503780040889163	20:18567346-18569563:+	SMIM26	3;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 26 [Source:HGNC Symbol%3BAcc:HGNC:43430]
ENSG00000102024	125.60	128.39	117.21	112.78	121.69	116.38	0.0926634612258994	7.96639640869316	0.146852943079777	0.503780040889163	X:115561173-115650861:+	PLS3	13;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0032432,cellular_component actin filament bundle;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051639,biological_process actin filament network formation;GO:0051764,biological_process actin crosslink formation;GO:0060348,biological_process bone development	NA	plastin 3 [Source:HGNC Symbol%3BAcc:HGNC:9091]
ENSG00000103647	3.63	4.71	4.04	5.46	3.74	5.81	-0.279114970257972	2.74971431869847	0.146889355457656	0.503780040889163	15:68578968-68727806:+	CORO2B	8;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0051015,molecular_function actin filament binding	NA	coronin 2B [Source:HGNC Symbol%3BAcc:HGNC:2256]
ENSG00000176046	1173.68	868.53	1244.49	1325.49	1095.05	1288.57	-0.162260456844121	8.53204247825332	0.146955179871173	0.503780040889163	16:28532707-28539174:-	NUPR1	22;GO:0002526,biological_process acute inflammatory response;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006473,biological_process protein acetylation;GO:0008584,biological_process male gonad development;GO:0009636,biological_process response to toxic substance;GO:0016049,biological_process cell growth;GO:0031401,biological_process positive regulation of protein modification process;GO:0032993,cellular_component protein-DNA complex;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045786,biological_process negative regulation of cell cycle;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:2000194,biological_process regulation of female gonad development	NUPR1, COM1; nuclear protein, 1; K15626	nuclear protein 1%2C transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:29990]
ENSG00000248487	5.49	5.69	5.72	4.95	5.02	4.77	0.208167290704617	2.70384800604296	0.146977212459916	0.503780040889163	3:51971425-51981199:+	ABHD14A	5;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	abhydrolase domain containing 14A [Source:HGNC Symbol%3BAcc:HGNC:24538]
ENSG00000120832	11.31	10.76	11.02	11.28	9.59	8.71	0.17781810351123	3.60971978975356	0.14704391561679	0.503780040889163	12:106977290-106987166:-	MTERF2	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006393,biological_process termination of mitochondrial transcription;GO:0042645,cellular_component mitochondrial nucleoid	NA	mitochondrial transcription termination factor 2 [Source:HGNC Symbol%3BAcc:HGNC:30779]
ENSG00000144381	301.54	347.59	288.89	329.68	352.68	337.26	-0.108883321642592	9.24233492106703	0.147050306727951	0.503780040889163	2:197486580-197516737:-	HSPD1	68;GO:0000166,molecular_function nucleotide binding;GO:0001530,molecular_function lipopolysaccharide binding;GO:0002039,molecular_function p53 binding;GO:0002368,biological_process B cell cytokine production;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002842,biological_process positive regulation of T cell mediated immune response to tumor cell;GO:0003688,molecular_function DNA replication origin binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006986,biological_process response to unfolded protein;GO:0008035,molecular_function high-density lipoprotein particle binding;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009409,biological_process response to cold;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0019899,molecular_function enzyme binding;GO:0019907,cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0030135,cellular_component coated vesicle;GO:0030141,cellular_component secretory granule;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0034185,molecular_function apolipoprotein binding;GO:0034186,molecular_function apolipoprotein A-I binding;GO:0042026,biological_process protein refolding;GO:0042100,biological_process B cell proliferation;GO:0042110,biological_process T cell activation;GO:0042113,biological_process B cell activation;GO:0043032,biological_process positive regulation of macrophage activation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0044183,molecular_function protein binding involved in protein folding;GO:0045041,biological_process protein import into mitochondrial intermembrane space;GO:0046696,cellular_component lipopolysaccharide receptor complex;GO:0048291,biological_process isotype switching to IgG isotypes;GO:0050821,biological_process protein stabilization;GO:0050870,biological_process positive regulation of T cell activation;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051604,biological_process protein maturation;GO:0051702,biological_process interaction with symbiont;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome	groEL, HSPD1; chaperonin GroEL; K04077	heat shock protein family D (Hsp60) member 1 [Source:HGNC Symbol%3BAcc:HGNC:5261]
ENSG00000123353	55.55	57.46	57.89	52.52	58.49	44.89	0.145319123015471	4.65087840845057	0.147079583354735	0.503780040889163	12:55817918-55821879:+	ORMDL2	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006672,biological_process ceramide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035339,cellular_component SPOTS complex;GO:0090155,biological_process negative regulation of sphingolipid biosynthetic process;GO:0090156,biological_process cellular sphingolipid homeostasis;GO:1900060,biological_process negative regulation of ceramide biosynthetic process	NA	ORMDL sphingolipid biosynthesis regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:16037]
ENSG00000187713	41.89	39.82	40.23	32.85	40.52	37.40	0.152234479741885	3.99804898120768	0.147243900505388	0.504203734337485	9:137204081-137205638:-	TMEM203	7;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 203 [Source:HGNC Symbol%3BAcc:HGNC:28217]
ENSG00000129173	10.18	12.42	8.69	10.19	12.60	12.79	-0.180252777397573	4.86204740494282	0.147316518682935	0.504313278105701	11:19224062-19241620:-	E2F8	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001890,biological_process placenta development;GO:0002040,biological_process sprouting angiogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0032466,biological_process negative regulation of cytokinesis;GO:0032877,biological_process positive regulation of DNA endoreduplication;GO:0033301,biological_process cell cycle comprising mitosis without cytokinesis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060707,biological_process trophoblast giant cell differentiation;GO:0060718,biological_process chorionic trophoblast cell differentiation;GO:0070365,biological_process hepatocyte differentiation	NA	E2F transcription factor 8 [Source:HGNC Symbol%3BAcc:HGNC:24727]
ENSG00000157259	42.80	45.59	47.06	36.37	39.94	47.75	0.136377296348977	5.13186322294876	0.147688334605173	0.505384848542322	7:92447452-92458836:+	GATAD1	8;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0031497,biological_process chromatin assembly;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	GATA zinc finger domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29941]
ENSG00000100031	87.09	90.07	87.63	77.60	89.29	82.52	0.0978138453368567	7.27924175324186	0.147744711919699	0.505384848542322	22:24583749-24629005:+	GGT1	27;GO:0002682,biological_process regulation of immune system process;GO:0002951,molecular_function leukotriene-C(4) hydrolase;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006691,biological_process leukotriene metabolic process;GO:0006749,biological_process glutathione metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0006751,biological_process glutathione catabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0007283,biological_process spermatogenesis;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016787,molecular_function hydrolase activity;GO:0019344,biological_process cysteine biosynthetic process;GO:0031638,biological_process zymogen activation;GO:0036374,molecular_function glutathione hydrolase activity;GO:0050727,biological_process regulation of inflammatory response;GO:0070062,cellular_component extracellular exosome;GO:0102953,molecular_function hypoglycin A gamma-glutamyl transpeptidase activity;GO:1901750,biological_process leukotriene D4 biosynthetic process	ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]; K00681	gamma-glutamyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:4250]
ENSG00000167491	23.65	23.31	25.81	25.15	27.31	26.43	-0.102820240519221	5.59409309103943	0.147751680928066	0.505384848542322	19:19385825-19508931:+	GATAD2A	14;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006306,biological_process DNA methylation;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016581,cellular_component NuRD complex;GO:0016607,cellular_component nuclear speck;GO:0030674,molecular_function protein binding, bridging;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	GATA zinc finger domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:29989]
ENSG00000174238	54.24	52.80	54.15	63.73	55.95	55.39	-0.106349541406577	5.75676788473519	0.147792872968504	0.505386482688167	17:1517717-1562816:-	PITPNA	17;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0007409,biological_process axonogenesis;GO:0007601,biological_process visual perception;GO:0008289,molecular_function lipid binding;GO:0008525,molecular_function phosphatidylcholine transporter activity;GO:0008526,molecular_function phosphatidylinositol transporter activity;GO:0015914,biological_process phospholipid transport;GO:0031210,molecular_function phosphatidylcholine binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043209,cellular_component myelin sheath;GO:0070062,cellular_component extracellular exosome;GO:1901611,molecular_function phosphatidylglycerol binding	NA	phosphatidylinositol transfer protein alpha [Source:HGNC Symbol%3BAcc:HGNC:9001]
ENSG00000116120	40.01	36.07	39.28	43.35	39.70	41.63	-0.0975545006500118	6.14889868665463	0.147852018089476	0.505449490648489	2:222570535-222656337:-	FARSB	16;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004826,molecular_function phenylalanine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006432,biological_process phenylalanyl-tRNA aminoacylation;GO:0009328,cellular_component phenylalanine-tRNA ligase complex;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0051290,biological_process protein heterotetramerization	FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]; K01890	phenylalanyl-tRNA synthetase beta subunit [Source:HGNC Symbol%3BAcc:HGNC:17800]
ENSG00000137513	23.82	20.75	22.92	21.44	19.01	22.10	0.125592450534352	4.96589748287634	0.147984804773528	0.505538483085137	11:78435960-78574874:-	NARS2	14;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004816,molecular_function asparagine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006421,biological_process asparaginyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity	NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]; K01893	asparaginyl-tRNA synthetase 2%2C mitochondrial (putative) [Source:HGNC Symbol%3BAcc:HGNC:26274]
ENSG00000137216	30.47	29.33	31.58	33.72	30.63	34.37	-0.0985906011144062	6.30993909480895	0.148046189497177	0.505538483085137	6:44126913-44155519:+	TMEM63B	6;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 63B [Source:HGNC Symbol%3BAcc:HGNC:17735]
ENSG00000049130	15.18	17.27	15.19	13.80	14.08	14.94	0.155880785966987	3.63919194760184	0.148083428958316	0.505538483085137	12:88492792-88580851:-	KITLG	43;GO:0000165,biological_process MAPK cascade;GO:0001541,biological_process ovarian follicle development;GO:0001755,biological_process neural crest cell migration;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0002763,biological_process positive regulation of myeloid leukocyte differentiation;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005125,molecular_function cytokine activity;GO:0005173,molecular_function stem cell factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0008083,molecular_function growth factor activity;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0033026,biological_process negative regulation of mast cell apoptotic process;GO:0035162,biological_process embryonic hemopoiesis;GO:0035234,biological_process ectopic germ cell programmed cell death;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045636,biological_process positive regulation of melanocyte differentiation;GO:0045740,biological_process positive regulation of DNA replication;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0070668,biological_process positive regulation of mast cell proliferation;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1902035,biological_process positive regulation of hematopoietic stem cell proliferation	KITLG; KIT ligand; K05461	KIT ligand [Source:HGNC Symbol%3BAcc:HGNC:6343]
ENSG00000161888	29.95	37.48	24.51	27.18	29.54	24.76	0.180412050127596	4.98864591802217	0.148133974318205	0.505538483085137	19:11131519-11155808:-	SPC24	12;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0031262,cellular_component Ndc80 complex;GO:0051301,biological_process cell division	NA	SPC24%2C NDC80 kinetochore complex component [Source:HGNC Symbol%3BAcc:HGNC:26913]
ENSG00000156875	4.56	4.88	4.26	3.26	4.44	4.07	0.224814073951963	2.67018452979468	0.14815765019335	0.505538483085137	1:100038096-100083377:+	MFSD14A	5;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	major facilitator superfamily domain containing 14A [Source:HGNC Symbol%3BAcc:HGNC:23363]
ENSG00000179958	37.67	42.72	31.32	40.08	43.57	41.64	-0.162237447853777	4.34061647134686	0.148199676767316	0.505538483085137	16:30423618-30430075:-	DCTPP1	18;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006253,biological_process dCTP catabolic process;GO:0009143,biological_process nucleoside triphosphate catabolic process;GO:0016462,molecular_function pyrophosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0032556,molecular_function pyrimidine deoxyribonucleotide binding;GO:0042262,biological_process DNA protection;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0047429,molecular_function nucleoside-triphosphate diphosphatase activity;GO:0047840,molecular_function dCTP diphosphatase activity;GO:0051289,biological_process protein homotetramerization	DCTPP1; dCTP diphosphatase [EC:3.6.1.12]; K16904	dCTP pyrophosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:28777]
ENSG00000124299	43.01	49.41	42.60	38.57	46.48	39.84	0.121816820806767	6.07545070965655	0.148210205696748	0.505538483085137	19:33386949-33521794:-	PEPD	14;GO:0004177,molecular_function aminopeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0005515,molecular_function protein binding;GO:0006508,biological_process proteolysis;GO:0006520,biological_process cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016805,molecular_function dipeptidase activity;GO:0030145,molecular_function manganese ion binding;GO:0030574,biological_process collagen catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0102009,molecular_function proline dipeptidase activity	NA	peptidase D [Source:HGNC Symbol%3BAcc:HGNC:8840]
ENSG00000143641	67.08	64.27	59.59	59.01	62.12	58.70	0.0982968321284912	6.72860881507453	0.148223320715379	0.505538483085137	1:230057989-230282124:+	GALNT2	24;GO:0000139,cellular_component Golgi membrane;GO:0002378,biological_process immunoglobulin biosynthetic process;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018242,biological_process protein O-linked glycosylation via serine;GO:0018243,biological_process protein O-linked glycosylation via threonine;GO:0030145,molecular_function manganese ion binding;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030246,molecular_function carbohydrate binding;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	polypeptide N-acetylgalactosaminyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:4124]
ENSG00000277149	0.67	0.90	0.63	0.60	0.39	0.56	0.47311387407545	0.543723991641816	0.148313217542414	0.505538483085137	7:72558743-72828198:-	TYW1B	8;GO:0003824,molecular_function catalytic activity;GO:0008033,biological_process tRNA processing;GO:0010181,molecular_function FMN binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process	NA	tRNA-yW synthesizing protein 1 homolog B [Source:HGNC Symbol%3BAcc:HGNC:33908]
ENSG00000228623	0.87	0.17	0.58	0.92	0.60	1.11	-0.613401454166035	-0.0188830088990774	0.148377060406509	0.505538483085137	9:112957721-113050043:-	ZNF883	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 883 [Source:HGNC Symbol%3BAcc:HGNC:27271]
ENSG00000121671	4.41	4.59	4.32	4.12	4.05	3.56	0.193957702930331	2.99117701576619	0.148432876835156	0.505538483085137	11:45847117-45883248:+	CRY2	43;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006606,biological_process protein import into nucleus;GO:0007623,biological_process circadian rhythm;GO:0009416,biological_process response to light stimulus;GO:0009785,biological_process blue light signaling pathway;GO:0009881,molecular_function photoreceptor activity;GO:0009882,molecular_function blue light photoreceptor activity;GO:0016607,cellular_component nuclear speck;GO:0016829,molecular_function lyase activity;GO:0018298,biological_process protein-chromophore linkage;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0019915,biological_process lipid storage;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0032868,biological_process response to insulin;GO:0032922,biological_process circadian regulation of gene expression;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0042593,biological_process glucose homeostasis;GO:0042752,biological_process regulation of circadian rhythm;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0050896,biological_process response to stimulus;GO:0071949,molecular_function FAD binding;GO:2000118,biological_process regulation of sodium-dependent phosphate transport;GO:2000323,biological_process negative regulation of glucocorticoid receptor signaling pathway;GO:2000850,biological_process negative regulation of glucocorticoid secretion	CRY; cryptochrome; K02295	cryptochrome circadian clock 2 [Source:HGNC Symbol%3BAcc:HGNC:2385]
ENSG00000123094	13.91	12.25	14.10	15.15	14.99	14.61	-0.132849508359184	4.21423619649623	0.148454747354556	0.505538483085137	12:25959028-26079892:+	RASSF8	2;GO:0007165,biological_process signal transduction;GO:0034334,biological_process adherens junction maintenance	NA	Ras association domain family member 8 [Source:HGNC Symbol%3BAcc:HGNC:13232]
ENSG00000081760	12.02	11.68	10.83	11.34	10.00	10.56	0.125337392856955	4.67292501489641	0.148474430473962	0.505538483085137	12:125065378-125143333:+	AACS	28;GO:0000166,molecular_function nucleotide binding;GO:0001889,biological_process liver development;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0010243,biological_process response to organonitrogen compound;GO:0014070,biological_process response to organic cyclic compound;GO:0014074,biological_process response to purine-containing compound;GO:0016874,molecular_function ligase activity;GO:0030729,molecular_function acetoacetate-CoA ligase activity;GO:0032024,biological_process positive regulation of insulin secretion;GO:0034201,biological_process response to oleic acid;GO:0042493,biological_process response to drug;GO:0042594,biological_process response to starvation;GO:0045471,biological_process response to ethanol;GO:0046951,biological_process ketone body biosynthetic process;GO:0047760,molecular_function butyrate-CoA ligase activity;GO:0050872,biological_process white fat cell differentiation;GO:0060612,biological_process adipose tissue development;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071394,biological_process cellular response to testosterone stimulus;GO:0071397,biological_process cellular response to cholesterol	AACS, acsA; acetoacetyl-CoA synthetase [EC:6.2.1.16]; K01907	acetoacetyl-CoA synthetase [Source:HGNC Symbol%3BAcc:HGNC:21298]
ENSG00000213741	396.59	287.80	321.58	384.15	330.79	413.25	-0.151682218865414	6.53704153471627	0.148482713856221	0.505538483085137	14:49570983-49599164:-	RPS29	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008270,molecular_function zinc ion binding;GO:0015935,cellular_component small ribosomal subunit;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	RP-S29e, RPS29; small subunit ribosomal protein S29e; K02980	ribosomal protein S29 [Source:HGNC Symbol%3BAcc:HGNC:10419]
ENSG00000198870	0.62	0.75	0.36	0.40	0.30	0.48	0.522476616376061	0.173722082687303	0.148540341061745	0.505538483085137	9:133376366-133406096:+	STKLD1	5;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation	NA	serine/threonine kinase like domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28669]
ENSG00000144730	1.66	1.68	1.53	2.23	2.46	1.43	-0.316023241180889	2.07281576767722	0.148548333782476	0.505538483085137	3:57089981-57170306:-	IL17RD	12;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030368,molecular_function interleukin-17 receptor activity	NA	interleukin 17 receptor D [Source:HGNC Symbol%3BAcc:HGNC:17616]
ENSG00000087263	20.64	22.04	19.38	21.16	23.27	23.18	-0.116175340833197	5.16763828542799	0.148628788006171	0.505538483085137	16:56451489-56479100:+	OGFOD1	19;GO:0005506,molecular_function iron ion binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006449,biological_process regulation of translational termination;GO:0008283,biological_process cell proliferation;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0018126,biological_process protein hydroxylation;GO:0019511,biological_process peptidyl-proline hydroxylation;GO:0031418,molecular_function L-ascorbic acid binding;GO:0031543,molecular_function peptidyl-proline dioxygenase activity;GO:0031544,molecular_function peptidyl-proline 3-dioxygenase activity;GO:0034063,biological_process stress granule assembly;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25585]
ENSG00000117020	23.99	20.11	25.40	22.49	19.86	21.65	0.136677389312586	5.04989141052314	0.148676628048281	0.505538483085137	1:243488232-243851079:-	AKT3	21;GO:0000002,biological_process mitochondrial genome maintenance;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032008,biological_process positive regulation of TOR signaling;GO:0035556,biological_process intracellular signal transduction;GO:0045793,biological_process positive regulation of cell size;GO:0048854,biological_process brain morphogenesis;GO:0048873,biological_process homeostasis of number of cells within a tissue	AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]; K04456	AKT serine/threonine kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:393]
ENSG00000176148	11.21	8.30	10.83	9.89	7.84	9.42	0.17995472813752	4.32073602615556	0.148679537072835	0.505538483085137	11:33039416-33105943:+	TCP11L1	1;GO:0005874,cellular_component microtubule	NA	t-complex 11 like 1 [Source:HGNC Symbol%3BAcc:HGNC:25655]
ENSG00000100335	19.36	15.71	17.89	19.15	18.66	20.57	-0.12225642532383	5.02492652921451	0.148710338194521	0.505538483085137	22:39499431-39518132:+	MIEF1	13;GO:0000166,molecular_function nucleotide binding;GO:0000266,biological_process mitochondrial fission;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019003,molecular_function GDP binding;GO:0042802,molecular_function identical protein binding;GO:0043531,molecular_function ADP binding;GO:0071456,biological_process cellular response to hypoxia;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090314,biological_process positive regulation of protein targeting to membrane	NA	mitochondrial elongation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:25979]
ENSG00000128309	57.09	55.59	52.98	52.15	48.91	54.72	0.0995713345090274	5.7879134927789	0.148733307035118	0.505538483085137	22:37019634-37029822:+	MPST	18;GO:0001822,biological_process kidney development;GO:0001889,biological_process liver development;GO:0004792,molecular_function thiosulfate sulfurtransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0009440,biological_process cyanate catabolic process;GO:0009636,biological_process response to toxic substance;GO:0016740,molecular_function transferase activity;GO:0016784,molecular_function 3-mercaptopyruvate sulfurtransferase activity;GO:0019346,biological_process transsulfuration;GO:0021510,biological_process spinal cord development;GO:0030054,cellular_component cell junction;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0070062,cellular_component extracellular exosome;GO:0070814,biological_process hydrogen sulfide biosynthetic process	TST, MPST, sseA; thiosulfate/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]; K01011	mercaptopyruvate sulfurtransferase [Source:HGNC Symbol%3BAcc:HGNC:7223]
ENSG00000143450	2.10	2.13	2.64	2.22	1.59	1.30	0.442228203003233	0.816638000983204	0.148912364013327	0.505893986589942	1:151762898-151771334:+	OAZ3	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0007283,biological_process spermatogenesis;GO:0008073,molecular_function ornithine decarboxylase inhibitor activity;GO:0015489,molecular_function putrescine transmembrane transporter activity;GO:0015847,biological_process putrescine transport;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0072562,cellular_component blood microparticle;GO:1902268,biological_process negative regulation of polyamine transmembrane transport	NA	ornithine decarboxylase antizyme 3 [Source:HGNC Symbol%3BAcc:HGNC:8097]
ENSG00000156970	16.39	16.76	16.10	16.42	19.39	17.64	-0.107091182038299	5.82491722857839	0.14891940924834	0.505893986589942	15:40161022-40221136:+	BUB1B	40;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000778,cellular_component condensed nuclear chromosome kinetochore;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005680,cellular_component anaphase-promoting complex;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007091,biological_process metaphase/anaphase transition of mitotic cell cycle;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0008283,biological_process cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0034501,biological_process protein localization to kinetochore;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051754,biological_process meiotic sister chromatid cohesion, centromeric;GO:0071459,biological_process protein localization to chromosome, centromeric region	BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]; K06637	BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol%3BAcc:HGNC:1149]
ENSG00000143514	25.39	34.83	27.28	25.77	29.09	24.47	0.150756595380611	6.56353265119972	0.148986250406984	0.50595873433487	1:223779898-223845972:-	TP53BP2	21;GO:0002039,molecular_function p53 binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0045786,biological_process negative regulation of cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051059,molecular_function NF-kappaB binding;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:1900119,biological_process positive regulation of execution phase of apoptosis;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1901216,biological_process positive regulation of neuron death;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TP53BP2, ASPP2; apoptosis-stimulating of p53 protein 2; K16823	tumor protein p53 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:12000]
ENSG00000163644	5.73	5.88	5.38	7.01	7.44	5.58	-0.224948140736568	2.82181635170922	0.149019989746901	0.50595873433487	4:88257619-88284769:-	PPM1K	11;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006470,biological_process protein dephosphorylation;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1K [Source:HGNC Symbol%3BAcc:HGNC:25415]
ENSG00000167920	18.89	18.15	19.30	22.35	19.40	21.08	-0.142860461204909	3.9601167445608	0.149160984718762	0.506180803653103	17:40819105-40836274:+	TMEM99	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 99 [Source:HGNC Symbol%3BAcc:HGNC:28305]
ENSG00000155367	2.22	1.89	2.36	3.00	2.11	2.91	-0.287545259147049	2.03537409861302	0.149166952369536	0.506180803653103	1:112709993-112715477:-	PPM1J	5;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0006470,biological_process protein dephosphorylation;GO:0016787,molecular_function hydrolase activity	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1J [Source:HGNC Symbol%3BAcc:HGNC:20785]
ENSG00000100106	19.48	19.16	19.36	20.91	19.11	22.71	-0.101452009437524	7.24701112787349	0.149325902727291	0.506457290108894	22:37697003-37776556:+	TRIOBP	18;GO:0003779,molecular_function actin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0007049,biological_process cell cycle;GO:0015629,cellular_component actin cytoskeleton;GO:0017049,molecular_function GTP-Rho binding;GO:0030047,biological_process actin modification;GO:0030496,cellular_component midbody;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0045159,molecular_function myosin II binding;GO:0051015,molecular_function actin filament binding;GO:0051016,biological_process barbed-end actin filament capping;GO:0051301,biological_process cell division;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	NA	TRIO and F-actin binding protein [Source:HGNC Symbol%3BAcc:HGNC:17009]
ENSG00000121578	37.06	40.26	36.31	34.81	36.41	35.03	0.104551222726909	5.27552071608714	0.149330031563567	0.506457290108894	3:119211731-119241103:-	B4GALT4	15;GO:0000139,cellular_component Golgi membrane;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945,molecular_function N-acetyllactosamine synthase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006643,biological_process membrane lipid metabolic process;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding	B4GALT4; beta-1,4-galactosyltransferase 4 [EC:2.4.1.90 2.4.1.275 2.4.1.-]; K07969	beta-1%2C4-galactosyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:927]
ENSG00000115415	109.31	139.63	102.61	116.64	158.63	124.49	-0.174046799455727	8.15361285241818	0.149590722247377	0.507138419221644	2:190964357-191020960:-	STAT1	62;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0001047,molecular_function core promoter binding;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0003340,biological_process negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007259,biological_process JAK-STAT cascade;GO:0008015,biological_process blood circulation;GO:0010742,biological_process macrophage derived foam cell differentiation;GO:0016032,biological_process viral process;GO:0016525,biological_process negative regulation of angiogenesis;GO:0019899,molecular_function enzyme binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034097,biological_process response to cytokine;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035456,biological_process response to interferon-beta;GO:0035458,biological_process cellular response to interferon-beta;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043434,biological_process response to peptide hormone;GO:0045296,molecular_function cadherin binding;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046725,biological_process negative regulation by virus of viral protein levels in host cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051591,biological_process response to cAMP;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0061326,biological_process renal tubule development;GO:0070491,molecular_function repressing transcription factor binding;GO:0071346,biological_process cellular response to interferon-gamma;GO:0072136,biological_process metanephric mesenchymal cell proliferation involved in metanephros development;GO:0072162,biological_process metanephric mesenchymal cell differentiation;GO:0072308,biological_process negative regulation of metanephric nephron tubule epithelial cell differentiation	STAT1; signal transducer and activator of transcription 1; K11220	signal transducer and activator of transcription 1 [Source:HGNC Symbol%3BAcc:HGNC:11362]
ENSG00000152495	0.55	1.14	0.62	0.79	1.12	1.39	-0.553362784915492	0.555654838910707	0.149612574815891	0.507138419221644	5:111223652-111494886:+	CAMK4	29;GO:0000166,molecular_function nucleotide binding;GO:0001650,cellular_component fibrillar center;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007616,biological_process long-term memory;GO:0009931,molecular_function calcium-dependent protein serine/threonine kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0033081,biological_process regulation of T cell differentiation in thymus;GO:0035556,biological_process intracellular signal transduction;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046777,biological_process protein autophosphorylation;GO:0070062,cellular_component extracellular exosome	CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]; K05869	calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol%3BAcc:HGNC:1464]
ENSG00000140259	40.17	46.08	40.07	36.90	40.08	40.79	0.108180267356669	5.74598504944226	0.149749711906638	0.507303341634878	15:43804491-43824802:-	MFAP1	6;GO:0001527,cellular_component microfibril;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process	NA	microfibril associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7032]
ENSG00000168000	16.68	16.90	14.32	14.41	15.58	13.87	0.135897092396632	4.49295980902802	0.149756014263695	0.507303341634878	11:62690274-62709845:-	BSCL2	13;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0019915,biological_process lipid storage;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034389,biological_process lipid particle organization;GO:0045444,biological_process fat cell differentiation;GO:0050995,biological_process negative regulation of lipid catabolic process	NA	BSCL2%2C seipin lipid droplet biogenesis associated [Source:HGNC Symbol%3BAcc:HGNC:15832]
ENSG00000125686	15.25	15.37	16.88	17.17	17.17	16.84	-0.0951434264544868	6.32962483101481	0.149783835260761	0.507303341634878	17:39404284-39451286:-	MED1	100;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000785,cellular_component chromatin;GO:0000902,biological_process cell morphogenesis;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001525,biological_process angiogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001889,biological_process liver development;GO:0001892,biological_process embryonic placenta development;GO:0002088,biological_process lens development in camera-type eye;GO:0002154,biological_process thyroid hormone mediated signaling pathway;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003406,biological_process retinal pigment epithelium development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006356,biological_process regulation of transcription from RNA polymerase I promoter;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006590,biological_process thyroid hormone generation;GO:0006702,biological_process androgen biosynthetic process;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007595,biological_process lactation;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030216,biological_process keratinocyte differentiation;GO:0030224,biological_process monocyte differentiation;GO:0030331,molecular_function estrogen receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030375,molecular_function thyroid hormone receptor coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031100,biological_process organ regeneration;GO:0031490,molecular_function chromatin DNA binding;GO:0032403,molecular_function protein complex binding;GO:0032993,cellular_component protein-DNA complex;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0035050,biological_process embryonic heart tube development;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035162,biological_process embryonic hemopoiesis;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035357,biological_process peroxisome proliferator activated receptor signaling pathway;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0035855,biological_process megakaryocyte development;GO:0036033,molecular_function mediator complex binding;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0042809,molecular_function vitamin D receptor binding;GO:0042974,molecular_function retinoic acid receptor binding;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0043010,biological_process camera-type eye development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045444,biological_process fat cell differentiation;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0048821,biological_process erythrocyte development;GO:0048822,biological_process enucleate erythrocyte development;GO:0050693,molecular_function LBD domain binding;GO:0051726,biological_process regulation of cell cycle;GO:0060335,biological_process positive regulation of interferon-gamma-mediated signaling pathway;GO:0060744,biological_process mammary gland branching involved in thelarche;GO:0060745,biological_process mammary gland branching involved in pregnancy;GO:0060750,biological_process epithelial cell proliferation involved in mammary gland duct elongation;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070318,biological_process positive regulation of G0 to G1 transition;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070562,biological_process regulation of vitamin D receptor signaling pathway;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:2000273,biological_process positive regulation of receptor activity;GO:2000347,biological_process positive regulation of hepatocyte proliferation;GO:2001141,biological_process regulation of RNA biosynthetic process	MED1; mediator of RNA polymerase II transcription subunit 1; K15144	mediator complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:9234]
ENSG00000074935	24.06	20.24	24.52	21.14	20.95	21.78	0.125874192165502	5.02238479621973	0.149870856650348	0.507459613639052	6:112070776-112087529:-	TUBE1	11;GO:0000166,molecular_function nucleotide binding;GO:0000242,cellular_component pericentriolar material;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007017,biological_process microtubule-based process;GO:0007098,biological_process centrosome cycle	NA	tubulin epsilon 1 [Source:HGNC Symbol%3BAcc:HGNC:20775]
ENSG00000111530	35.67	38.48	33.79	32.35	35.74	33.23	0.101614041827242	7.01453864948809	0.149971706748712	0.507626917534279	12:67269280-67319951:+	CAND1	23;GO:0000151,cellular_component ubiquitin ligase complex;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006879,biological_process cellular iron ion homeostasis;GO:0010265,biological_process SCF complex assembly;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0017025,molecular_function TBP-class protein binding;GO:0030154,biological_process cell differentiation;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0034774,cellular_component secretory granule lumen;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	cullin associated and neddylation dissociated 1 [Source:HGNC Symbol%3BAcc:HGNC:30688]
ENSG00000183153	2.24	1.30	2.34	2.80	2.06	3.03	-0.382418339023626	1.14653672106007	0.150020857406158	0.507626917534279	17:40362930-40363815:-	GJD3	16;GO:0005216,molecular_function ion channel activity;GO:0005243,molecular_function gap junction channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005921,cellular_component gap junction;GO:0005922,cellular_component connexon complex;GO:0007154,biological_process cell communication;GO:0009749,biological_process response to glucose;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016264,biological_process gap junction assembly;GO:0030054,cellular_component cell junction;GO:0034220,biological_process ion transmembrane transport;GO:0055085,biological_process transmembrane transport	NA	gap junction protein delta 3 [Source:HGNC Symbol%3BAcc:HGNC:19147]
ENSG00000278129	5.08	5.10	4.99	5.95	5.45	5.83	-0.173498531901455	3.2453569519581	0.150068029457857	0.507626917534279	19:58278950-58302805:+	ZNF8	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0030509,biological_process BMP signaling pathway;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 8 [Source:HGNC Symbol%3BAcc:HGNC:13154]
ENSG00000156689	6.97	4.44	6.09	5.86	3.53	4.86	0.322513965021217	2.28036261553337	0.150105167114756	0.507626917534279	11:58834064-58904215:-	GLYATL2	5;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0047961,molecular_function glycine N-acyltransferase activity	NA	glycine-N-acyltransferase like 2 [Source:HGNC Symbol%3BAcc:HGNC:24178]
ENSG00000198315	13.05	12.96	12.97	14.91	12.93	15.09	-0.128340282350362	4.58813909707927	0.150124741341202	0.507626917534279	6:28141909-28159472:+	ZKSCAN8	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger with KRAB and SCAN domains 8 [Source:HGNC Symbol%3BAcc:HGNC:12983]
ENSG00000141971	38.78	36.76	39.08	42.56	39.87	41.85	-0.10232302696245	5.22823242597977	0.150190612678936	0.50771134945088	19:17405721-17433724:+	MVB12A	33;GO:0000813,cellular_component ESCRT I complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0017124,molecular_function SH3 domain binding;GO:0019058,biological_process viral life cycle;GO:0019075,biological_process virus maturation;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042058,biological_process regulation of epidermal growth factor receptor signaling pathway;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043657,cellular_component host cell;GO:0048524,biological_process positive regulation of viral process;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus;GO:1903772,biological_process regulation of viral budding via host ESCRT complex	FAM125; ESCRT-I complex subunit MVB12; K12186	multivesicular body subunit 12A [Source:HGNC Symbol%3BAcc:HGNC:25153]
ENSG00000146350	1.82	2.61	2.39	1.69	2.27	1.85	0.235170785267778	3.06970230150153	0.150385702747741	0.508091940233983	6:121079493-121334745:-	TBC1D32	16;GO:0002088,biological_process lens development in camera-type eye;GO:0003406,biological_process retinal pigment epithelium development;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0021915,biological_process neural tube development;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0060041,biological_process retina development in camera-type eye;GO:0060831,biological_process smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0061512,biological_process protein localization to cilium;GO:1905515,biological_process non-motile cilium assembly	NA	TBC1 domain family member 32 [Source:HGNC Symbol%3BAcc:HGNC:21485]
ENSG00000136908	35.15	36.43	38.12	33.07	35.03	32.16	0.14208905622691	3.97706341237078	0.150457577827107	0.508091940233983	9:127935098-127938484:-	DPM2	18;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0004582,molecular_function dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0019348,biological_process dolichol metabolic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030234,molecular_function enzyme regulator activity;GO:0031647,biological_process regulation of protein stability;GO:0033185,cellular_component dolichol-phosphate-mannose synthase complex;GO:0035269,biological_process protein O-linked mannosylation;GO:0050790,biological_process regulation of catalytic activity	DPM2; dolichol phosphate-mannose biosynthesis regulatory protein; K09658	dolichyl-phosphate mannosyltransferase subunit 2%2C regulatory [Source:HGNC Symbol%3BAcc:HGNC:3006]
ENSG00000170365	7.09	7.67	8.18	9.18	7.45	9.68	-0.188920257795383	3.53981446555375	0.150465494085611	0.508091940233983	4:145481193-145558079:+	SMAD1	62;GO:0000165,biological_process MAPK cascade;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001657,biological_process ureteric bud development;GO:0001710,biological_process mesodermal cell fate commitment;GO:0002051,biological_process osteoblast fate commitment;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007183,biological_process SMAD protein complex assembly;GO:0007276,biological_process gamete generation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009880,biological_process embryonic pattern specification;GO:0010628,biological_process positive regulation of gene expression;GO:0016021,cellular_component integral component of membrane;GO:0016579,biological_process protein deubiquitination;GO:0017151,molecular_function DEAD/H-box RNA helicase binding;GO:0019901,molecular_function protein kinase binding;GO:0030509,biological_process BMP signaling pathway;GO:0030618,molecular_function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity;GO:0030901,biological_process midbrain development;GO:0030902,biological_process hindbrain development;GO:0031053,biological_process primary miRNA processing;GO:0042592,biological_process homeostatic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051216,biological_process cartilage development;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060348,biological_process bone development;GO:0060395,biological_process SMAD protein signal transduction;GO:0061036,biological_process positive regulation of cartilage development;GO:0070410,molecular_function co-SMAD binding;GO:0070411,molecular_function I-SMAD binding;GO:0070878,molecular_function primary miRNA binding;GO:0071141,cellular_component SMAD protein complex;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071773,biological_process cellular response to BMP stimulus;GO:1901522,biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter	SMAD1; mothers against decapentaplegic homolog 1; K04676	SMAD family member 1 [Source:HGNC Symbol%3BAcc:HGNC:6767]
ENSG00000147475	17.56	17.14	19.01	14.94	17.27	17.14	0.136141445647869	4.42758694722138	0.150469045265335	0.508091940233983	8:37736598-37759101:+	ERLIN2	22;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032933,biological_process SREBP signaling pathway;GO:0043234,cellular_component protein complex;GO:0045121,cellular_component membrane raft;GO:0045541,biological_process negative regulation of cholesterol biosynthetic process;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	NA	ER lipid raft associated 2 [Source:HGNC Symbol%3BAcc:HGNC:1356]
ENSG00000113083	17.50	10.66	19.12	15.33	10.64	14.06	0.258669854698055	4.21480333432189	0.150524232065894	0.508091940233983	5:122063194-122078360:-	LOX	25;GO:0001568,biological_process blood vessel development;GO:0004720,molecular_function protein-lysine 6-oxidase activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0006464,biological_process cellular protein modification process;GO:0007507,biological_process heart development;GO:0009725,biological_process response to hormone;GO:0016491,molecular_function oxidoreductase activity;GO:0016641,molecular_function oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0030324,biological_process lung development;GO:0035904,biological_process aorta development;GO:0042060,biological_process wound healing;GO:0042493,biological_process response to drug;GO:0046872,molecular_function metal ion binding;GO:0048251,biological_process elastic fiber assembly;GO:0048514,biological_process blood vessel morphogenesis;GO:0048545,biological_process response to steroid hormone;GO:0055114,biological_process oxidation-reduction process	NA	lysyl oxidase [Source:HGNC Symbol%3BAcc:HGNC:6664]
ENSG00000107897	37.91	35.70	39.78	40.10	39.77	42.53	-0.0963439021144578	5.99554707688728	0.15055414224601	0.508091940233983	10:27195213-27242130:-	ACBD5	13;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0008289,molecular_function lipid binding;GO:0009062,biological_process fatty acid catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030242,biological_process pexophagy	NA	acyl-CoA binding domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:23338]
ENSG00000100266	70.49	67.80	69.32	74.16	72.67	75.79	-0.0884284648579207	6.82724936262692	0.15058972433101	0.508091940233983	22:42835411-43015145:-	PACSIN2	36;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006897,biological_process endocytosis;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0019898,cellular_component extrinsic component of membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030100,biological_process regulation of endocytosis;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032587,cellular_component ruffle membrane;GO:0036010,biological_process protein localization to endosome;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding;GO:0045806,biological_process negative regulation of endocytosis;GO:0048858,biological_process cell projection morphogenesis;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070300,molecular_function phosphatidic acid binding;GO:0070836,biological_process caveola assembly;GO:0072584,biological_process caveolin-mediated endocytosis;GO:0097320,biological_process membrane tubulation	NA	protein kinase C and casein kinase substrate in neurons 2 [Source:HGNC Symbol%3BAcc:HGNC:8571]
ENSG00000047056	5.71	6.46	6.13	4.96	6.51	4.31	0.223907450287086	3.18612530677889	0.150648864413044	0.508153357054108	10:1049537-1132297:+	WDR37	4;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000470,biological_process maturation of LSU-rRNA;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0070545,cellular_component PeBoW complex	NA	WD repeat domain 37 [Source:HGNC Symbol%3BAcc:HGNC:31406]
ENSG00000136960	4.82	4.68	5.76	4.27	4.40	5.02	0.171812764540231	3.80483691071967	0.150799590735249	0.508472184263896	8:119557085-119673453:-	ENPP2	37;GO:0003676,molecular_function nucleic acid binding;GO:0003824,molecular_function catalytic activity;GO:0004528,molecular_function phosphodiesterase I activity;GO:0004551,molecular_function nucleotide diphosphatase activity;GO:0004622,molecular_function lysophospholipase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006935,biological_process chemotaxis;GO:0006955,biological_process immune response;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008134,molecular_function transcription factor binding;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009395,biological_process phospholipid catabolic process;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030247,molecular_function polysaccharide binding;GO:0030334,biological_process regulation of cell migration;GO:0034638,biological_process phosphatidylcholine catabolic process;GO:0045765,biological_process regulation of angiogenesis;GO:0046872,molecular_function metal ion binding;GO:0047391,molecular_function alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0048870,biological_process cell motility;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:2000394,biological_process positive regulation of lamellipodium morphogenesis	ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2 [EC:3.1.4.39]; K01122	ectonucleotide pyrophosphatase/phosphodiesterase 2 [Source:HGNC Symbol%3BAcc:HGNC:3357]
ENSG00000106049	126.18	128.65	128.20	138.09	137.17	134.78	-0.0867764760755568	7.17575187713958	0.150833226710001	0.508472184263896	7:27525441-27662995:-	HIBADH	9;GO:0004616,molecular_function phosphogluconate dehydrogenase (decarboxylating) activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006574,biological_process valine catabolic process;GO:0008442,molecular_function 3-hydroxyisobutyrate dehydrogenase activity;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process	mmsB, HIBADH; 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]; K00020	3-hydroxyisobutyrate dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:4907]
ENSG00000127952	65.41	61.95	62.35	61.97	57.41	59.86	0.094754966427395	5.91045996337676	0.150866273636021	0.508472184263896	7:75996337-76048004:-	STYXL1	7;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005622,cellular_component intracellular;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0035556,biological_process intracellular signal transduction	NA	serine/threonine/tyrosine interacting like 1 [Source:HGNC Symbol%3BAcc:HGNC:18165]
ENSG00000172936	9.51	10.55	10.60	12.05	11.48	11.17	-0.170051765839716	3.39438548577714	0.150922746229605	0.508486487261214	3:38138477-38143022:+	MYD88	65;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002238,biological_process response to molecule of fungal origin;GO:0002376,biological_process immune system process;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0005102,molecular_function receptor binding;GO:0005121,molecular_function Toll binding;GO:0005123,molecular_function death receptor binding;GO:0005149,molecular_function interleukin-1 receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007254,biological_process JNK cascade;GO:0008063,biological_process Toll signaling pathway;GO:0009615,biological_process response to virus;GO:0009682,biological_process induced systemic resistance;GO:0010008,cellular_component endosome membrane;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0014069,cellular_component postsynaptic density;GO:0016064,biological_process immunoglobulin mediated immune response;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032494,biological_process response to peptidoglycan;GO:0032496,biological_process response to lipopolysaccharide;GO:0032675,biological_process regulation of interleukin-6 production;GO:0032680,biological_process regulation of tumor necrosis factor production;GO:0032740,biological_process positive regulation of interleukin-17 production;GO:0032747,biological_process positive regulation of interleukin-23 production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043621,molecular_function protein self-association;GO:0044130,biological_process negative regulation of growth of symbiont in host;GO:0045080,biological_process positive regulation of chemokine biosynthetic process;GO:0045087,biological_process innate immune response;GO:0045351,biological_process type I interferon biosynthetic process;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050671,biological_process positive regulation of lymphocyte proliferation;GO:0050727,biological_process regulation of inflammatory response;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060337,biological_process type I interferon signaling pathway;GO:0070555,biological_process response to interleukin-1;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:0070976,molecular_function TIR domain binding;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:0140052,Biological_Process cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response;GO:1902622,biological_process regulation of neutrophil migration;GO:2000338,biological_process regulation of chemokine (C-X-C motif) ligand 1 production;GO:2000341,biological_process regulation of chemokine (C-X-C motif) ligand 2 production	MYD88; myeloid differentiation primary response protein MyD88; K04729	myeloid differentiation primary response 88 [Source:HGNC Symbol%3BAcc:HGNC:7562]
ENSG00000133104	35.81	36.69	36.36	33.28	36.06	33.50	0.0933597343072167	6.14279742720086	0.150976919723764	0.508486487261214	13:36301637-36370180:-	SPART	18;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0009838,biological_process abscission;GO:0030496,cellular_component midbody;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034389,biological_process lipid particle organization;GO:0045202,cellular_component synapse;GO:0048698,biological_process negative regulation of collateral sprouting in absence of injury;GO:0050905,biological_process neuromuscular process;GO:0051301,biological_process cell division;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0060612,biological_process adipose tissue development	NA	spartin [Source:HGNC Symbol%3BAcc:HGNC:18514]
ENSG00000103479	32.44	31.30	33.96	34.77	35.00	35.17	-0.090046548120722	6.86148260399516	0.151032304004643	0.508486487261214	16:53433976-53491649:+	RBL2	18;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0010629,biological_process negative regulation of gene expression;GO:0016569,biological_process covalent chromatin modification;GO:0043550,biological_process regulation of lipid kinase activity;GO:0051726,biological_process regulation of cell cycle;GO:0070062,cellular_component extracellular exosome;GO:1990841,molecular_function promoter-specific chromatin binding	RBL2; retinoblastoma-like protein 2; K16332	RB transcriptional corepressor like 2 [Source:HGNC Symbol%3BAcc:HGNC:9894]
ENSG00000099331	15.14	16.10	14.55	13.57	15.03	14.46	0.0987316343063858	6.64522263166152	0.151034373522283	0.508486487261214	19:17075780-17214537:+	MYO9B	31;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005938,cellular_component cell cortex;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016459,cellular_component myosin complex;GO:0016887,molecular_function ATPase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0030048,biological_process actin filament-based movement;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035385,biological_process Roundabout signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0043531,molecular_function ADP binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048495,molecular_function Roundabout binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	myosin IXB [Source:HGNC Symbol%3BAcc:HGNC:7609]
ENSG00000184009	1674.00	1969.42	1617.08	1461.16	1866.73	1475.78	0.142817914707716	10.9349474179079	0.151184406671836	0.508853590026436	17:81509970-81523847:-	ACTG1	31;GO:0000166,molecular_function nucleotide binding;GO:0001895,biological_process retina homeostasis;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030016,cellular_component myofibril;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031941,cellular_component filamentous actin;GO:0034329,biological_process cell junction assembly;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042802,molecular_function identical protein binding;GO:0043209,cellular_component myelin sheath;GO:0045214,biological_process sarcomere organization;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0072562,cellular_component blood microparticle;GO:0097433,cellular_component dense body	ACTB_G1; actin beta/gamma 1; K05692	actin gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:144]
ENSG00000116406	7.60	8.37	9.24	6.92	8.61	7.32	0.153087663193557	4.51808332932398	0.151247484375907	0.508869999721619	1:184690230-184754913:-	EDEM3	17;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006486,biological_process protein glycosylation;GO:0006491,biological_process N-glycan processing;GO:0006516,biological_process glycoprotein catabolic process;GO:0006986,biological_process response to unfolded protein;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:1904382,biological_process mannose trimming involved in glycoprotein ERAD pathway	EDEM3; ER degradation enhancer, mannosidase alpha-like 3; K10086	ER degradation enhancing alpha-mannosidase like protein 3 [Source:HGNC Symbol%3BAcc:HGNC:16787]
ENSG00000178381	18.36	16.79	22.09	23.20	20.35	21.49	-0.164788697682059	3.90257788044562	0.151271271970738	0.508869999721619	7:1152070-1160759:-	ZFAND2A	7;GO:0000502,cellular_component proteasome complex;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0071243,biological_process cellular response to arsenic-containing substance	NA	zinc finger AN1-type containing 2A [Source:HGNC Symbol%3BAcc:HGNC:28073]
ENSG00000124145	113.07	115.35	106.06	121.76	123.08	115.42	-0.0965523052379412	6.1076985044687	0.151392215364407	0.509138870040203	20:45325287-45348424:-	SDC4	34;GO:0001523,biological_process retinoid metabolic process;GO:0001657,biological_process ureteric bud development;GO:0001843,biological_process neural tube closure;GO:0001968,molecular_function fibronectin binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0010762,biological_process regulation of fibroblast migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0042060,biological_process wound healing;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0043034,cellular_component costamere;GO:0043202,cellular_component lysosomal lumen;GO:0045121,cellular_component membrane raft;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0050900,biological_process leukocyte migration;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0070053,molecular_function thrombospondin receptor activity;GO:0070062,cellular_component extracellular exosome;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903553,biological_process positive regulation of extracellular exosome assembly	SDC4; syndecan 4; K16338	syndecan 4 [Source:HGNC Symbol%3BAcc:HGNC:10661]
ENSG00000151665	83.82	74.11	81.02	75.17	72.17	77.69	0.101510455475022	5.85227831856866	0.151555321808963	0.509549352550016	2:46580936-46617119:-	PIGF	7;GO:0004307,molecular_function ethanolaminephosphotransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane	PIGF; GPI ethanolamine phosphate transferase 2/3 subunit F; K05287	phosphatidylinositol glycan anchor biosynthesis class F [Source:HGNC Symbol%3BAcc:HGNC:8962]
ENSG00000124593	1.76	1.39	2.31	1.45	1.04	1.70	0.407823184063757	1.11427796603309	0.151682836207991	0.50981214072733	6:41780348-41790141:+	AL365205.1	NA	NA	NA
ENSG00000179562	15.40	15.00	16.14	14.78	13.83	15.00	0.107126199136775	5.13422577108325	0.151807733864226	0.50981214072733	7:127580617-127593611:-	GCC1	8;GO:0000042,biological_process protein targeting to Golgi;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	GRIP and coiled-coil domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19095]
ENSG00000127837	67.34	68.11	66.48	72.86	72.97	70.88	-0.0905176860815844	6.58727166821028	0.151810256501592	0.50981214072733	2:218264122-218270257:-	AAMP	17;GO:0001525,biological_process angiogenesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008201,molecular_function heparin binding;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0014909,biological_process smooth muscle cell migration;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0045171,cellular_component intercellular bridge;GO:0051082,molecular_function unfolded protein binding	NA	angio associated migratory cell protein [Source:HGNC Symbol%3BAcc:HGNC:18]
ENSG00000105402	71.05	73.90	70.50	67.59	71.89	63.19	0.0993195183412903	6.12144824070915	0.151833466671974	0.50981214072733	19:47487636-47515240:-	NAPA	33;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0005483,molecular_function soluble NSF attachment protein activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005774,cellular_component vacuolar membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0007420,biological_process brain development;GO:0010807,biological_process regulation of synaptic vesicle priming;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030182,biological_process neuron differentiation;GO:0031201,cellular_component SNARE complex;GO:0032403,molecular_function protein complex binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035494,biological_process SNARE complex disassembly;GO:0043195,cellular_component terminal bouton;GO:0043209,cellular_component myelin sheath;GO:0043241,biological_process protein complex disassembly;GO:0045176,biological_process apical protein localization;GO:0048208,biological_process COPII vesicle coating;GO:0061025,biological_process membrane fusion;GO:0070044,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0070062,cellular_component extracellular exosome	NAPA, SNAPA, SEC17; alpha-soluble NSF attachment protein; K15296	NSF attachment protein alpha [Source:HGNC Symbol%3BAcc:HGNC:7641]
ENSG00000071564	27.95	25.99	25.83	29.03	28.18	28.58	-0.0919112232728641	6.12566160853659	0.151838837047365	0.50981214072733	19:1609289-1652605:-	TCF3	37;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002326,biological_process B cell lineage commitment;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0016607,cellular_component nuclear speck;GO:0030154,biological_process cell differentiation;GO:0030183,biological_process B cell differentiation;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0033152,biological_process immunoglobulin V(D)J recombination;GO:0035326,molecular_function enhancer binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043425,molecular_function bHLH transcription factor binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0070491,molecular_function repressing transcription factor binding;GO:0070644,molecular_function vitamin D response element binding;GO:0070888,molecular_function E-box binding;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	TCF3, E2A; transcription factor E2-alpha; K09063	transcription factor 3 [Source:HGNC Symbol%3BAcc:HGNC:11633]
ENSG00000138814	35.27	30.44	33.71	37.48	36.59	34.01	-0.104286875267406	5.79516439884712	0.152079837559664	0.510314585156892	4:101023408-101348278:-	PPP3CA	57;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0001975,biological_process response to amphetamine;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004723,molecular_function calcium-dependent protein serine/threonine phosphatase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005955,cellular_component calcineurin complex;GO:0006470,biological_process protein dephosphorylation;GO:0006606,biological_process protein import into nucleus;GO:0006816,biological_process calcium ion transport;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0008144,molecular_function drug binding;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0014883,biological_process transition between fast and slow fiber;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0016018,molecular_function cyclosporin A binding;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0019722,biological_process calcium-mediated signaling;GO:0019899,molecular_function enzyme binding;GO:0030018,cellular_component Z disc;GO:0033173,biological_process calcineurin-NFAT signaling cascade;GO:0033192,molecular_function calmodulin-dependent protein phosphatase activity;GO:0033555,biological_process multicellular organismal response to stress;GO:0035562,biological_process negative regulation of chromatin binding;GO:0035690,biological_process cellular response to drug;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042110,biological_process T cell activation;GO:0042383,cellular_component sarcolemma;GO:0045807,biological_process positive regulation of endocytosis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048741,biological_process skeletal muscle fiber development;GO:0050774,biological_process negative regulation of dendrite morphogenesis;GO:0050804,biological_process modulation of synaptic transmission;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051533,biological_process positive regulation of NFAT protein import into nucleus;GO:0051592,biological_process response to calcium ion;GO:0060079,biological_process excitatory postsynaptic potential;GO:0071333,biological_process cellular response to glucose stimulus;GO:0098794,cellular_component postsynapse;GO:1903244,biological_process positive regulation of cardiac muscle hypertrophy in response to stress;GO:1903799,biological_process negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:1905205,biological_process positive regulation of connective tissue replacement	PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]; K04348	protein phosphatase 3 catalytic subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:9314]
ENSG00000106400	197.05	199.82	187.67	184.91	182.22	186.15	0.0899630314833609	6.45588644705405	0.152103622240513	0.510314585156892	7:101217667-101224190:+	ZNHIT1	9;GO:0000812,cellular_component Swr1 complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0031063,biological_process regulation of histone deacetylation;GO:0031491,molecular_function nucleosome binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043486,biological_process histone exchange;GO:0046872,molecular_function metal ion binding	NA	zinc finger HIT-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21688]
ENSG00000093072	4.25	4.04	4.33	3.26	3.98	3.73	0.216792983571277	2.65454629035229	0.152122628211906	0.510314585156892	22:17178789-17221989:-	ADA2	19;GO:0004000,molecular_function adenosine deaminase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006154,biological_process adenosine catabolic process;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0019239,molecular_function deaminase activity;GO:0031685,molecular_function adenosine receptor binding;GO:0035578,cellular_component azurophil granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043103,biological_process hypoxanthine salvage;GO:0043312,biological_process neutrophil degranulation;GO:0043394,molecular_function proteoglycan binding;GO:0044267,biological_process cellular protein metabolic process;GO:0046103,biological_process inosine biosynthetic process;GO:0046872,molecular_function metal ion binding	NA	adenosine deaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:1839]
ENSG00000151789	13.16	11.53	12.45	11.25	9.53	12.59	0.169213182103296	3.85804956447414	0.152152926743386	0.510314585156892	3:21412221-22373321:-	ZNF385D	7;GO:0002039,molecular_function p53 binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	NA	zinc finger protein 385D [Source:HGNC Symbol%3BAcc:HGNC:26191]
ENSG00000120798	28.68	25.50	27.73	24.57	25.86	26.60	0.1036345455577	5.6399908926905	0.152307181820525	0.510693962165905	12:95020228-95073703:-	NR2C1	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0016605,cellular_component PML body;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048386,biological_process positive regulation of retinoic acid receptor signaling pathway	NA	nuclear receptor subfamily 2 group C member 1 [Source:HGNC Symbol%3BAcc:HGNC:7971]
ENSG00000179010	432.28	431.42	424.22	458.47	457.05	461.04	-0.0843889063780687	7.40479782089534	0.152384404336337	0.51081490981014	4:6640090-6642745:+	MRFAP1	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	Morf4 family associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24549]
ENSG00000103496	55.88	51.87	57.39	63.53	53.66	62.70	-0.109963928881478	6.03414596611282	0.152472887135587	0.510973528081545	16:31032888-31042975:+	STX4	54;GO:0000149,molecular_function SNARE binding;GO:0000322,cellular_component storage vacuole;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005773,cellular_component vacuole;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0006886,biological_process intracellular protein transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0008021,cellular_component synaptic vesicle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016230,molecular_function sphingomyelin phosphodiesterase activator activity;GO:0016323,cellular_component basolateral plasma membrane;GO:0017157,biological_process regulation of exocytosis;GO:0030027,cellular_component lamellipodium;GO:0030335,biological_process positive regulation of cell migration;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0033194,biological_process response to hydroperoxide;GO:0035493,biological_process SNARE complex assembly;GO:0035749,cellular_component myelin sheath adaxonal region;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0036477,cellular_component somatodendritic compartment;GO:0042581,cellular_component specific granule;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043197,cellular_component dendritic spine;GO:0043219,cellular_component lateral loop;GO:0043311,biological_process positive regulation of eosinophil degranulation;GO:0045202,cellular_component synapse;GO:0045785,biological_process positive regulation of cell adhesion;GO:0048278,biological_process vesicle docking;GO:0048284,biological_process organelle fusion;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050921,biological_process positive regulation of chemotaxis;GO:0051024,biological_process positive regulation of immunoglobulin secretion;GO:0060291,biological_process long-term synaptic potentiation;GO:0070062,cellular_component extracellular exosome;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:1990668,biological_process vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:2000010,biological_process positive regulation of protein localization to cell surface	STX4; syntaxin 4; K13502	syntaxin 4 [Source:HGNC Symbol%3BAcc:HGNC:11439]
ENSG00000242574	0.81	1.21	0.65	1.80	0.87	1.34	-0.607612300647252	0.0372526014606707	0.152588146261685	0.511135832196109	6:32934628-32941070:-	HLA-DMB	17;GO:0002376,biological_process immune system process;GO:0002399,biological_process MHC class II protein complex assembly;GO:0002503,biological_process peptide antigen assembly with MHC class II protein complex;GO:0002504,biological_process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006955,biological_process immune response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019882,biological_process antigen processing and presentation;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0023026,molecular_function MHC class II protein complex binding;GO:0031902,cellular_component late endosome membrane;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042613,cellular_component MHC class II protein complex;GO:2001190,biological_process positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	MHC2; MHC class II antigen; K06752	major histocompatibility complex%2C class II%2C DM beta [Source:HGNC Symbol%3BAcc:HGNC:4935]
ENSG00000158186	42.33	36.60	42.11	49.07	42.90	42.15	-0.129764227917945	4.74257493303983	0.152638432687203	0.511135832196109	3:138347647-138405534:+	MRAS	15;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030742,molecular_function GTP-dependent protein binding;GO:0070062,cellular_component extracellular exosome;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	muscle RAS oncogene homolog [Source:HGNC Symbol%3BAcc:HGNC:7227]
ENSG00000275993	3.37	2.44	3.23	3.86	2.71	4.43	-0.263112019119761	3.0146476995808	0.152644850555947	0.511135832196109	21:6111133-6123739:+	CU639417.2	11;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0032870,biological_process cellular response to hormone stimulus;GO:0035556,biological_process intracellular signal transduction	NA	NA
ENSG00000119688	29.11	26.55	25.81	29.08	28.74	30.17	-0.0980707380137331	5.83720072967806	0.152878911475946	0.511610551025275	14:74285422-74303056:-	ABCD4	15;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005765,cellular_component lysosomal membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0009235,biological_process cobalamin metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043190,cellular_component ATP-binding cassette (ABC) transporter complex;GO:0055085,biological_process transmembrane transport;GO:1990830,biological_process cellular response to leukemia inhibitory factor	ABCD4, PXMP1L; ATP-binding cassette, subfamily D (ALD), member 4; K05678	ATP binding cassette subfamily D member 4 [Source:HGNC Symbol%3BAcc:HGNC:68]
ENSG00000176658	17.09	17.11	16.81	19.91	17.42	17.88	-0.102807869503533	5.7754928769032	0.152901869694983	0.511610551025275	17:32492521-32877177:-	MYO1D	29;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005768,cellular_component endosome;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005903,cellular_component brush border;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016323,cellular_component basolateral plasma membrane;GO:0016459,cellular_component myosin complex;GO:0019904,molecular_function protein domain specific binding;GO:0030424,cellular_component axon;GO:0030673,cellular_component axolemma;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0030900,biological_process forebrain development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043209,cellular_component myelin sheath;GO:0044853,cellular_component plasma membrane raft;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051015,molecular_function actin filament binding;GO:0051641,biological_process cellular localization;GO:0061502,biological_process early endosome to recycling endosome transport;GO:0070062,cellular_component extracellular exosome;GO:0097440,cellular_component apical dendrite	MYO1; myosin I; K10356	myosin ID [Source:HGNC Symbol%3BAcc:HGNC:7598]
ENSG00000147400	106.08	116.68	99.85	102.44	107.74	87.76	0.124330027309526	5.73999000459254	0.152977275865632	0.511610551025275	X:152826972-152830777:-	CETN2	34;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007099,biological_process centriole replication;GO:0007283,biological_process spermatogenesis;GO:0008017,molecular_function microtubule binding;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0032465,biological_process regulation of cytokinesis;GO:0032795,molecular_function heterotrimeric G-protein binding;GO:0036064,cellular_component ciliary basal body;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0071942,cellular_component XPC complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	CETN2; centrin-2; K10840	centrin 2 [Source:HGNC Symbol%3BAcc:HGNC:1867]
ENSG00000138381	24.04	23.16	25.31	26.62	24.49	27.30	-0.0995000530697591	5.81979949757854	0.15299152101857	0.511610551025275	2:189661384-189670831:+	ASNSD1	8;GO:0003674,molecular_function molecular_function;GO:0004066,molecular_function asparagine synthase (glutamine-hydrolyzing) activity;GO:0005575,cellular_component cellular_component;GO:0006529,biological_process asparagine biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0008150,biological_process biological_process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0042803,molecular_function protein homodimerization activity	NA	asparagine synthetase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24910]
ENSG00000155313	33.52	30.69	32.84	29.84	28.54	32.90	0.10142156973436	6.73069308887468	0.153021211336439	0.511610551025275	21:15730024-15880069:+	USP25	21;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043130,molecular_function ubiquitin binding;GO:0051117,molecular_function ATPase binding;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:1904293,biological_process negative regulation of ERAD pathway;GO:1904455,molecular_function ubiquitin-specific protease activity involved in negative regulation of ERAD pathway	USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]; K11849	ubiquitin specific peptidase 25 [Source:HGNC Symbol%3BAcc:HGNC:12624]
ENSG00000213047	2.02	2.02	1.80	2.23	2.39	2.27	-0.230761554403179	2.40085617647614	0.153061733890484	0.511610551025275	1:197504747-197775696:-	DENND1B	16;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016607,cellular_component nuclear speck;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032456,biological_process endocytic recycling;GO:0035745,biological_process T-helper 2 cell cytokine production;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050776,biological_process regulation of immune response;GO:0050852,biological_process T cell receptor signaling pathway;GO:0061024,biological_process membrane organization	NA	DENN domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:28404]
ENSG00000151164	0.29	0.86	0.76	0.88	0.84	1.02	-0.547833843566946	0.341461112224664	0.153075129824206	0.511610551025275	12:110501654-110532086:+	RAD9B	13;GO:0000075,biological_process cell cycle checkpoint;GO:0000076,biological_process DNA replication checkpoint;GO:0000077,biological_process DNA damage checkpoint;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0030896,cellular_component checkpoint clamp complex;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0071479,biological_process cellular response to ionizing radiation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RAD9B; cell cycle checkpoint control protein RAD9B; K10995	RAD9 checkpoint clamp component B [Source:HGNC Symbol%3BAcc:HGNC:21700]
ENSG00000075391	4.74	5.09	4.84	5.27	5.65	5.22	-0.129530537922332	4.33715458267698	0.153135793747918	0.511675533726221	1:178094140-178484147:+	RASAL2	10;GO:0000165,biological_process MAPK cascade;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction	NA	RAS protein activator like 2 [Source:HGNC Symbol%3BAcc:HGNC:9874]
ENSG00000181027	4.04	2.96	3.62	3.78	4.34	4.55	-0.227022873901615	2.57726712762431	0.153184512032053	0.511700578001582	19:46746045-46776988:+	FKRP	18;GO:0000139,cellular_component Golgi membrane;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0009101,biological_process glycoprotein biosynthetic process;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016740,molecular_function transferase activity;GO:0035269,biological_process protein O-linked mannosylation;GO:0042383,cellular_component sarcolemma	NA	fukutin related protein [Source:HGNC Symbol%3BAcc:HGNC:17997]
ENSG00000134627	5.02	4.80	5.18	4.87	3.75	4.79	0.174649788901935	3.65691959872498	0.153339645777242	0.511819651517748	11:94543839-94621421:+	PIWIL4	16;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006417,biological_process regulation of translation;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0010529,biological_process negative regulation of transposition;GO:0030154,biological_process cell differentiation;GO:0031047,biological_process gene silencing by RNA;GO:0034584,molecular_function piRNA binding;GO:0034587,biological_process piRNA metabolic process;GO:0043046,biological_process DNA methylation involved in gamete generation;GO:0043186,cellular_component P granule;GO:0051321,biological_process meiotic cell cycle;GO:0071547,cellular_component piP-body	AUB, PIWI; aubergine; K02156	piwi like RNA-mediated gene silencing 4 [Source:HGNC Symbol%3BAcc:HGNC:18444]
ENSG00000196196	19.86	15.51	15.79	23.00	20.00	17.94	-0.22914921581269	2.72923192059199	0.153349583608277	0.511819651517748	9:35906191-35907141:+	HRCT1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	histidine rich carboxyl terminus 1 [Source:HGNC Symbol%3BAcc:HGNC:33872]
ENSG00000164466	36.64	38.34	38.11	39.45	40.11	42.75	-0.103630964988865	5.28192559542074	0.153373963479097	0.511819651517748	5:175477061-175529742:+	SFXN1	13;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006826,biological_process iron ion transport;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030218,biological_process erythrocyte differentiation;GO:0031966,cellular_component mitochondrial membrane;GO:0034220,biological_process ion transmembrane transport;GO:0055072,biological_process iron ion homeostasis;GO:0055085,biological_process transmembrane transport	NA	sideroflexin 1 [Source:HGNC Symbol%3BAcc:HGNC:16085]
ENSG00000126698	193.06	206.82	188.65	216.49	214.41	202.16	-0.0945445653831379	7.33505444318723	0.153385088507695	0.511819651517748	1:28199455-28233025:-	DNAJC8	4;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0045171,cellular_component intercellular bridge	NA	DnaJ heat shock protein family (Hsp40) member C8 [Source:HGNC Symbol%3BAcc:HGNC:15470]
ENSG00000134575	17.28	16.38	16.98	16.84	16.17	13.19	0.148265645021207	4.47114521657518	0.153465379538867	0.511949947921515	11:47239301-47248906:-	ACP2	11;GO:0001501,biological_process skeletal system development;GO:0003993,molecular_function acid phosphatase activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0007040,biological_process lysosome organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0043202,cellular_component lysosomal lumen;GO:0070062,cellular_component extracellular exosome	ACP2; lysosomal acid phosphatase [EC:3.1.3.2]; K14410	acid phosphatase 2%2C lysosomal [Source:HGNC Symbol%3BAcc:HGNC:123]
ENSG00000120690	18.09	18.00	19.01	20.09	20.35	19.23	-0.10148147221358	5.24701635184425	0.153590130181929	0.512228448669607	13:40932027-41061440:-	ELF1	18;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001817,biological_process regulation of cytokine production;GO:0001959,biological_process regulation of cytokine-mediated signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050855,biological_process regulation of B cell receptor signaling pathway;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway	ELF1_2_4; E74-like factor 1/2/4; K09428	E74 like ETS transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:3316]
ENSG00000182263	6.73	9.07	6.36	6.11	6.52	6.91	0.180303709437736	4.02651891910362	0.153652932943772	0.512238936687631	2:163593395-163736012:-	FIGN	13;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0016363,cellular_component nuclear matrix;GO:0016887,molecular_function ATPase activity;GO:0051301,biological_process cell division	NA	fidgetin%2C microtubule severing factor [Source:HGNC Symbol%3BAcc:HGNC:13285]
ENSG00000168411	10.58	10.91	11.51	12.54	12.05	11.51	-0.117222633249098	4.75073942934539	0.153675807639148	0.512238936687631	16:74621393-74666881:-	RFWD3	21;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0002039,molecular_function p53 binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010212,biological_process response to ionizing radiation;GO:0016567,biological_process protein ubiquitination;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0031297,biological_process replication fork processing;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0035861,cellular_component site of double-strand break;GO:0036297,biological_process interstrand cross-link repair;GO:0046872,molecular_function metal ion binding;GO:0090734,cellular_component site of DNA damage;GO:0097371,molecular_function MDM2/MDM4 family protein binding;GO:2000001,biological_process regulation of DNA damage checkpoint	NA	ring finger and WD repeat domain 3 [Source:HGNC Symbol%3BAcc:HGNC:25539]
ENSG00000275052	41.65	39.40	41.24	44.06	43.44	43.65	-0.0881624956306502	6.75288183488789	0.154121345214359	0.513466460883234	2:55547291-55618880:-	PPP4R3B	11;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006470,biological_process protein dephosphorylation;GO:0016607,cellular_component nuclear speck;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030289,cellular_component protein phosphatase 4 complex;GO:0045722,biological_process positive regulation of gluconeogenesis	NA	protein phosphatase 4 regulatory subunit 3B [Source:HGNC Symbol%3BAcc:HGNC:29267]
ENSG00000146376	36.40	31.52	39.00	39.49	35.54	42.35	-0.120182936739605	6.2226500798981	0.154154520563967	0.513466460883234	6:129576131-129710225:-	ARHGAP18	14;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016607,cellular_component nuclear speck;GO:0030833,biological_process regulation of actin filament polymerization;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:2000145,biological_process regulation of cell motility	NA	Rho GTPase activating protein 18 [Source:HGNC Symbol%3BAcc:HGNC:21035]
ENSG00000154079	34.22	43.65	37.48	45.76	41.90	42.54	-0.174468335272916	3.74222028577822	0.154191113139379	0.513466460883234	6:70566916-70589569:+	SDHAF4	11;GO:0003407,biological_process neural retina development;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005749,cellular_component mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0005759,cellular_component mitochondrial matrix;GO:0008177,molecular_function succinate dehydrogenase (ubiquinone) activity;GO:0034553,biological_process mitochondrial respiratory chain complex II assembly;GO:0045087,biological_process innate immune response;GO:0045333,biological_process cellular respiration;GO:0097032,biological_process mitochondrial respiratory chain complex II biogenesis	NA	succinate dehydrogenase complex assembly factor 4 [Source:HGNC Symbol%3BAcc:HGNC:20957]
ENSG00000011422	29.61	23.23	28.14	33.06	25.49	32.40	-0.151460939453216	5.23106038738441	0.154375444161662	0.513466460883234	19:43646094-43670547:-	PLAUR	38;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0006935,biological_process chemotaxis;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016255,biological_process attachment of GPI anchor to protein;GO:0019898,cellular_component extrinsic component of membrane;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030162,biological_process regulation of proteolysis;GO:0030377,molecular_function urokinase plasminogen activator receptor activity;GO:0031225,cellular_component anchored component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0038195,biological_process urokinase plasminogen activator signaling pathway;GO:0042730,biological_process fibrinolysis;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0043388,biological_process positive regulation of DNA binding;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071438,cellular_component invadopodium membrane;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway;GO:2001268,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PLAUR, CD87; plasminogen activator, urokinase receptor; K03985	plasminogen activator%2C urokinase receptor [Source:HGNC Symbol%3BAcc:HGNC:9053]
ENSG00000113273	4.52	4.29	4.21	3.69	4.15	3.55	0.208908067194359	2.75599346293808	0.154381066932829	0.513466460883234	5:78777208-78986087:-	ARSB	33;GO:0003824,molecular_function catalytic activity;GO:0003943,molecular_function N-acetylgalactosamine-4-sulfatase activity;GO:0004065,molecular_function arylsulfatase activity;GO:0005576,cellular_component extracellular region;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006914,biological_process autophagy;GO:0007040,biological_process lysosome organization;GO:0007041,biological_process lysosomal transport;GO:0007417,biological_process central nervous system development;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0009268,biological_process response to pH;GO:0009986,cellular_component cell surface;GO:0010632,biological_process regulation of epithelial cell migration;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016787,molecular_function hydrolase activity;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043627,biological_process response to estrogen;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0051597,biological_process response to methylmercury;GO:0061580,biological_process colon epithelial cell migration;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	ARSB; arylsulfatase B [EC:3.1.6.12]; K01135	arylsulfatase B [Source:HGNC Symbol%3BAcc:HGNC:714]
ENSG00000128242	139.92	146.65	141.18	132.79	142.32	129.58	0.0912718985011962	7.46520670984307	0.154381385097544	0.513466460883234	22:30554634-30574587:-	GAL3ST1	15;GO:0000139,cellular_component Golgi membrane;GO:0001733,molecular_function galactosylceramide sulfotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0006487,biological_process protein N-linked glycosylation;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006682,biological_process galactosylceramide biosynthetic process;GO:0007283,biological_process spermatogenesis;GO:0008146,molecular_function sulfotransferase activity;GO:0009247,biological_process glycolipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0042552,biological_process myelination	GAL3ST1; galactosylceramide sulfotransferase [EC:2.8.2.11]; K01019	galactose-3-O-sulfotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:24240]
ENSG00000134183	2.26	2.70	2.22	2.47	3.07	3.44	-0.327414144102995	1.59188660555946	0.154395086934559	0.513466460883234	1:109603266-109619929:-	GNAT2	27;GO:0000166,molecular_function nucleotide binding;GO:0001580,biological_process detection of chemical stimulus involved in sensory perception of bitter taste;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005525,molecular_function GTP binding;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007601,biological_process visual perception;GO:0007602,biological_process phototransduction;GO:0008020,molecular_function G-protein coupled photoreceptor activity;GO:0009642,biological_process response to light intensity;GO:0019001,molecular_function guanyl nucleotide binding;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0042622,cellular_component photoreceptor outer segment membrane;GO:0046549,biological_process retinal cone cell development;GO:0046872,molecular_function metal ion binding;GO:0050896,biological_process response to stimulus;GO:0050908,biological_process detection of light stimulus involved in visual perception	GNAT1_2; guanine nucleotide-binding protein G(t) subunit alpha 1/2; K04631	G protein subunit alpha transducin 2 [Source:HGNC Symbol%3BAcc:HGNC:4394]
ENSG00000105607	9.35	11.32	9.62	10.05	11.50	12.39	-0.162006424469303	4.20812764714945	0.15439663757485	0.513466460883234	19:12891025-12914207:+	GCDH	16;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0004361,molecular_function glutaryl-CoA dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006554,biological_process lysine catabolic process;GO:0006568,biological_process tryptophan metabolic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0019395,biological_process fatty acid oxidation;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	GCDH, gcdH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]; K00252	glutaryl-CoA dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:4189]
ENSG00000197043	185.69	212.85	185.06	206.27	225.64	201.23	-0.106307058251003	8.72847514185092	0.154445365766947	0.513466460883234	5:151100711-151157882:-	ANXA6	24;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005925,cellular_component focal adhesion;GO:0006816,biological_process calcium ion transport;GO:0006937,biological_process regulation of muscle contraction;GO:0008289,molecular_function lipid binding;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0031902,cellular_component late endosome membrane;GO:0034220,biological_process ion transmembrane transport;GO:0042470,cellular_component melanosome;GO:0042803,molecular_function protein homodimerization activity;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051260,biological_process protein homooligomerization;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0097190,biological_process apoptotic signaling pathway	NA	annexin A6 [Source:HGNC Symbol%3BAcc:HGNC:544]
ENSG00000101246	47.47	34.65	46.91	48.84	45.33	50.99	-0.149419131651798	4.80284168710919	0.154457726974784	0.513466460883234	20:63698641-63708025:-	ARFRP1	16;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007369,biological_process gastrulation;GO:0016020,cellular_component membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043001,biological_process Golgi to plasma membrane protein transport	NA	ADP ribosylation factor related protein 1 [Source:HGNC Symbol%3BAcc:HGNC:662]
ENSG00000177051	9.06	11.15	9.11	9.48	8.51	8.40	0.154248538523291	4.07606198012949	0.154530477544839	0.513570767808323	19:45710628-45730904:-	FBXO46	1;GO:0005515,molecular_function protein binding	NA	F-box protein 46 [Source:HGNC Symbol%3BAcc:HGNC:25069]
ENSG00000111237	94.82	95.27	95.17	96.81	104.77	105.10	-0.0930380837441152	5.99640284981538	0.15469064714988	0.513837120333856	12:110491096-110502117:-	VPS29	21;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008270,molecular_function zinc ion binding;GO:0008565,molecular_function protein transporter activity;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030904,cellular_component retromer complex;GO:0030906,cellular_component retromer, cargo-selective complex;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	VPS29%2C retromer complex component [Source:HGNC Symbol%3BAcc:HGNC:14340]
ENSG00000196415	6.16	4.48	6.80	5.65	3.95	4.76	0.30853732917589	2.08831680484801	0.154693411640024	0.513837120333856	19:840959-848175:+	PRTN3	20;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007596,biological_process blood coagulation;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016787,molecular_function hydrolase activity;GO:0019730,biological_process antimicrobial humoral response;GO:0019899,molecular_function enzyme binding;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0050765,biological_process negative regulation of phagocytosis;GO:0070062,cellular_component extracellular exosome;GO:0097029,biological_process mature conventional dendritic cell differentiation	NA	proteinase 3 [Source:HGNC Symbol%3BAcc:HGNC:9495]
ENSG00000156171	82.13	80.60	83.75	77.31	73.47	81.95	0.0947222359130109	5.99849618521979	0.154776387654775	0.513843660405391	1:111117332-111140216:-	DRAM2	15;GO:0001917,cellular_component photoreceptor inner segment;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0007601,biological_process visual perception;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045494,biological_process photoreceptor cell maintenance	NA	DNA damage regulated autophagy modulator 2 [Source:HGNC Symbol%3BAcc:HGNC:28769]
ENSG00000197386	11.40	12.65	10.49	12.48	13.90	11.49	-0.122747466331762	6.83182997234643	0.154778171776022	0.513843660405391	4:3074680-3243959:+	HTT	42;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0002039,molecular_function p53 binding;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006915,biological_process apoptotic process;GO:0007030,biological_process Golgi organization;GO:0008134,molecular_function transcription factor binding;GO:0016234,cellular_component inclusion body;GO:0019900,molecular_function kinase binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031072,molecular_function heat shock protein binding;GO:0031587,biological_process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0031648,biological_process protein destabilization;GO:0034452,molecular_function dynactin binding;GO:0042297,biological_process vocal learning;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043666,biological_process regulation of phosphoprotein phosphatase activity;GO:0044325,molecular_function ion channel binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0045724,biological_process positive regulation of cilium assembly;GO:0047496,biological_process vesicle transport along microtubule;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048487,molecular_function beta-tubulin binding;GO:0048513,biological_process animal organ development;GO:1903599,biological_process positive regulation of mitophagy;GO:1904504,biological_process positive regulation of lipophagy;GO:1905337,biological_process positive regulation of aggrephagy;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	HD; huntingtin; K04533	huntingtin [Source:HGNC Symbol%3BAcc:HGNC:4851]
ENSG00000181396	19.95	18.33	19.40	17.65	18.88	17.16	0.11959294685149	4.74369377163102	0.155186302332579	0.514923291766478	17:82389222-82418637:-	OGFOD3	10;GO:0005506,molecular_function iron ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0031418,molecular_function L-ascorbic acid binding;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	2-oxoglutarate and iron dependent oxygenase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:26174]
ENSG00000197461	17.00	16.34	16.41	21.41	15.77	19.62	-0.179012213470127	3.71934610560764	0.155186339684073	0.514923291766478	7:497257-520296:-	PDGFA	61;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0001525,biological_process angiogenesis;GO:0001775,biological_process cell activation;GO:0001942,biological_process hair follicle development;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002576,biological_process platelet degranulation;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005902,cellular_component microvillus;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009611,biological_process response to wounding;GO:0009887,biological_process organ morphogenesis;GO:0009986,cellular_component cell surface;GO:0010512,biological_process negative regulation of phosphatidylinositol biosynthetic process;GO:0010544,biological_process negative regulation of platelet activation;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014910,biological_process regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0030031,biological_process cell projection assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035793,biological_process positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042060,biological_process wound healing;GO:0042803,molecular_function protein homodimerization activity;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043588,biological_process skin development;GO:0045740,biological_process positive regulation of DNA replication;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048286,biological_process lung alveolus development;GO:0048407,molecular_function platelet-derived growth factor binding;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050919,biological_process negative chemotaxis;GO:0051781,biological_process positive regulation of cell division;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060683,biological_process regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:1990401,biological_process embryonic lung development;GO:2000587,biological_process negative regulation of platelet-derived growth factor receptor-beta signaling pathway	PDGFA; platelet-derived growth factor subunit A; K04359	platelet derived growth factor subunit A [Source:HGNC Symbol%3BAcc:HGNC:8799]
ENSG00000112378	60.62	64.21	58.98	52.63	62.87	54.89	0.118924429451383	5.09993495450049	0.155275349067708	0.514984321692598	6:138088504-138107511:-	PERP	19;GO:0002934,biological_process desmosome organization;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007155,biological_process cell adhesion;GO:0007219,biological_process Notch signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0042981,biological_process regulation of apoptotic process;GO:0045862,biological_process positive regulation of proteolysis;GO:0070268,biological_process cornification;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0097186,biological_process amelogenesis;GO:0097202,biological_process activation of cysteine-type endopeptidase activity	PERP; TP53 apoptosis effector; K10136	PERP%2C TP53 apoptosis effector [Source:HGNC Symbol%3BAcc:HGNC:17637]
ENSG00000090470	11.46	11.36	11.53	12.25	12.56	13.10	-0.130479814777494	4.14619393751735	0.155287707733456	0.514984321692598	15:65117378-65133836:-	PDCD7	7;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006915,biological_process apoptotic process;GO:0008380,biological_process RNA splicing;GO:0051384,biological_process response to glucocorticoid	NA	programmed cell death 7 [Source:HGNC Symbol%3BAcc:HGNC:8767]
ENSG00000189376	3.53	4.11	2.78	3.09	2.46	2.96	0.285199141493361	1.89365307446943	0.155436220615506	0.515246955832809	8:123219956-123241398:-	C8orf76	NA	NA	chromosome 8 open reading frame 76 [Source:HGNC Symbol%3BAcc:HGNC:25924]
ENSG00000203867	0.21	0.21	0.08	0.28	0.29	0.19	-0.611145123876095	-0.112816545790551	0.155449919406579	0.515246955832809	10:110644396-110839469:+	RBM20	9;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0007507,biological_process heart development;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0033120,biological_process positive regulation of RNA splicing;GO:0043484,biological_process regulation of RNA splicing	NA	RNA binding motif protein 20 [Source:HGNC Symbol%3BAcc:HGNC:27424]
ENSG00000100445	64.78	60.04	61.33	58.54	59.83	57.82	0.0933342895514337	5.90655812031023	0.155568439933323	0.515502147595393	14:24439765-24442905:-	SDR39U1	3;GO:0005634,cellular_component nucleus;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	short chain dehydrogenase/reductase family 39U member 1 [Source:HGNC Symbol%3BAcc:HGNC:20275]
ENSG00000103121	64.88	62.74	63.58	74.57	64.28	69.75	-0.113020893211745	5.0437663200796	0.155615914623519	0.515521843667398	16:80966447-81020270:-	CMC2	1;GO:0005739,cellular_component mitochondrion	NA	C-X9-C motif containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24447]
ENSG00000132334	4.08	4.68	4.80	5.24	4.95	5.09	-0.164490443821913	3.62220681988169	0.155870045156309	0.516225952648148	10:127907060-128085855:+	PTPRE	15;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway	NA	protein tyrosine phosphatase%2C receptor type E [Source:HGNC Symbol%3BAcc:HGNC:9669]
ENSG00000118418	257.15	276.40	247.60	234.98	258.06	241.79	0.0983088133208663	6.62464058840896	0.155914203436346	0.51623446445862	6:79201244-79234738:-	HMGN3	14;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008150,biological_process biological_process;GO:0016569,biological_process covalent chromatin modification;GO:0031492,molecular_function nucleosomal DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus	NA	high mobility group nucleosomal binding domain 3 [Source:HGNC Symbol%3BAcc:HGNC:12312]
ENSG00000180855	4.56	4.08	3.62	3.68	3.39	3.67	0.203614553245915	2.97596820964861	0.156067691655879	0.516428897873984	19:12429706-12441112:-	ZNF443	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 443 [Source:HGNC Symbol%3BAcc:HGNC:20878]
ENSG00000137713	13.43	16.24	12.51	11.76	14.59	11.60	0.15900953146903	4.86718879273687	0.156087318297242	0.516428897873984	11:111726907-111766427:-	PPP2R1B	5;GO:0005515,molecular_function protein binding;GO:0045121,cellular_component membrane raft;GO:0060561,biological_process apoptotic process involved in morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A; K03456	protein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol%3BAcc:HGNC:9303]
ENSG00000253276	16.33	17.86	16.87	14.15	14.56	17.53	0.148280342943228	4.02382231522697	0.156153691954577	0.516428897873984	7:106656764-106660996:-	CCDC71L	NA	NA	coiled-coil domain containing 71 like [Source:HGNC Symbol%3BAcc:HGNC:26685]
ENSG00000182199	201.14	162.08	204.43	220.79	190.10	213.32	-0.124570687322946	8.26482798253852	0.156186341998132	0.516428897873984	12:57229326-57234935:+	SHMT2	36;GO:0003682,molecular_function chromatin binding;GO:0003824,molecular_function catalytic activity;GO:0004372,molecular_function glycine hydroxymethyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0006544,biological_process glycine metabolic process;GO:0006545,biological_process glycine biosynthetic process;GO:0006563,biological_process L-serine metabolic process;GO:0006564,biological_process L-serine biosynthetic process;GO:0006730,biological_process one-carbon metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008732,molecular_function L-allo-threonine aldolase activity;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016597,molecular_function amino acid binding;GO:0016740,molecular_function transferase activity;GO:0019264,biological_process glycine biosynthetic process from serine;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0032259,biological_process methylation;GO:0034340,biological_process response to type I interferon;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0042645,cellular_component mitochondrial nucleoid;GO:0042802,molecular_function identical protein binding;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046655,biological_process folic acid metabolic process;GO:0051262,biological_process protein tetramerization;GO:0051289,biological_process protein homotetramerization;GO:0070062,cellular_component extracellular exosome;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070552,cellular_component BRISC complex	glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]; K00600	serine hydroxymethyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:10852]
ENSG00000100348	87.48	79.72	74.41	76.37	77.22	71.98	0.112313715109566	5.42345668401279	0.156197897999717	0.516428897873984	22:36467035-36482030:-	TXN2	24;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006662,biological_process glycerol ether metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0007584,biological_process response to nutrient;GO:0008113,molecular_function peptide-methionine (S)-S-oxide reductase activity;GO:0009725,biological_process response to hormone;GO:0009749,biological_process response to glucose;GO:0014070,biological_process response to organic cyclic compound;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0030425,cellular_component dendrite;GO:0031669,biological_process cellular response to nutrient levels;GO:0032403,molecular_function protein complex binding;GO:0033743,molecular_function peptide-methionine (R)-S-oxide reductase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0042493,biological_process response to drug;GO:0043025,cellular_component neuronal cell body;GO:0045454,biological_process cell redox homeostasis;GO:0048678,biological_process response to axon injury;GO:0055114,biological_process oxidation-reduction process	NA	thioredoxin 2 [Source:HGNC Symbol%3BAcc:HGNC:17772]
ENSG00000188641	12.46	9.58	11.21	10.16	9.12	11.14	0.145691457891896	5.05657304590479	0.156260916793953	0.516428897873984	1:97077742-97921049:-	DPYD	22;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006145,biological_process purine nucleobase catabolic process;GO:0006208,biological_process pyrimidine nucleobase catabolic process;GO:0006210,biological_process thymine catabolic process;GO:0006212,biological_process uracil catabolic process;GO:0006214,biological_process thymidine catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0017113,molecular_function dihydropyrimidine dehydrogenase (NADP+) activity;GO:0019483,biological_process beta-alanine biosynthetic process;GO:0042803,molecular_function protein homodimerization activity;GO:0046135,biological_process pyrimidine nucleoside catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050661,molecular_function NADP binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process	DPYD; dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]; K00207	dihydropyrimidine dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:3012]
ENSG00000225932	0.24	0.61	0.38	0.67	0.55	0.51	-0.532778862263293	0.370508610153655	0.156264472023149	0.516428897873984	7:144183465-144186053:+	CTAGE4	4;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CTAGE family member 4 [Source:HGNC Symbol%3BAcc:HGNC:24772]
ENSG00000100911	132.93	112.93	131.52	148.52	126.40	137.02	-0.112561650194677	6.71855662561276	0.156367046596581	0.516428897873984	14:24143361-24147570:-	PSME2	38;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008537,cellular_component proteasome activator complex;GO:0010950,biological_process positive regulation of endopeptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061133,molecular_function endopeptidase activator activity;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	PSME2; proteasome activator subunit 2 (PA28 beta); K06697	proteasome activator subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:9569]
ENSG00000136938	371.70	358.66	358.23	383.21	381.33	397.54	-0.0823118155627147	8.14364287164048	0.156384108477659	0.516428897873984	9:97983360-98015943:+	ANP32B	16;GO:0001944,biological_process vasculature development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0021591,biological_process ventricular system development;GO:0042393,molecular_function histone binding;GO:0043486,biological_process histone exchange;GO:0045596,biological_process negative regulation of cell differentiation;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0048839,biological_process inner ear development;GO:0060021,biological_process palate development;GO:0070062,cellular_component extracellular exosome;GO:0070063,molecular_function RNA polymerase binding	NA	acidic nuclear phosphoprotein 32 family member B [Source:HGNC Symbol%3BAcc:HGNC:16677]
ENSG00000135631	16.04	17.06	16.08	16.66	18.46	17.85	-0.0973799329246354	6.08323815638704	0.156388965367623	0.516428897873984	2:73073381-73156721:-	RAB11FIP5	27;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030141,cellular_component secretory granule;GO:0030658,cellular_component transport vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0035773,biological_process insulin secretion involved in cellular response to glucose stimulus;GO:0043015,molecular_function gamma-tubulin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045055,biological_process regulated exocytosis;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0070164,biological_process negative regulation of adiponectin secretion;GO:0071468,biological_process cellular response to acidic pH;GO:2000008,biological_process regulation of protein localization to cell surface	RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5; K12484	RAB11 family interacting protein 5 [Source:HGNC Symbol%3BAcc:HGNC:24845]
ENSG00000075188	30.89	32.15	27.53	34.65	30.92	33.55	-0.122754876155179	4.9621324995999	0.156470931149321	0.516540615182805	12:102073102-102120124:-	NUP37	29;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031080,cellular_component nuclear pore outer ring;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0051301,biological_process cell division;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP37; nuclear pore complex protein Nup37; K14302	nucleoporin 37 [Source:HGNC Symbol%3BAcc:HGNC:29929]
ENSG00000164713	236.18	218.60	227.21	221.13	209.87	214.94	0.0913092857652704	6.77586641732187	0.156600797787924	0.516540615182805	7:98252378-98310441:+	BRI3	6;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation	NA	brain protein I3 [Source:HGNC Symbol%3BAcc:HGNC:1109]
ENSG00000187796	1.66	1.44	2.43	2.25	2.01	2.79	-0.325660811502787	1.87993256652119	0.156606775040901	0.516540615182805	9:136361902-136373681:-	CARD9	29;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0009620,biological_process response to fungus;GO:0019904,molecular_function protein domain specific binding;GO:0032494,biological_process response to peptidoglycan;GO:0032495,biological_process response to muramyl dipeptide;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0042493,biological_process response to drug;GO:0042534,biological_process regulation of tumor necrosis factor biosynthetic process;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043330,biological_process response to exogenous dsRNA;GO:0045076,biological_process regulation of interleukin-2 biosynthetic process;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0045408,biological_process regulation of interleukin-6 biosynthetic process;GO:0046330,biological_process positive regulation of JNK cascade;GO:0050700,molecular_function CARD domain binding;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051607,biological_process defense response to virus	CARD9; caspase recruitment domain-containing protein 9; K12794	caspase recruitment domain family member 9 [Source:HGNC Symbol%3BAcc:HGNC:16391]
ENSG00000075945	12.97	13.79	15.10	10.89	13.84	13.60	0.13862474265669	5.04644703561827	0.156610840977579	0.516540615182805	1:169921325-170085208:-	KIFAP3	31;GO:0000794,cellular_component condensed nuclear chromosome;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005871,cellular_component kinesin complex;GO:0005876,cellular_component spindle microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006461,biological_process protein complex assembly;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007017,biological_process microtubule-based process;GO:0007018,biological_process microtubule-based movement;GO:0007165,biological_process signal transduction;GO:0008104,biological_process protein localization;GO:0008285,biological_process negative regulation of cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016939,cellular_component kinesin II complex;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019894,molecular_function kinesin binding;GO:0030990,cellular_component intraciliary transport particle;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046587,biological_process positive regulation of calcium-dependent cell-cell adhesion;GO:0070062,cellular_component extracellular exosome;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule;GO:0097542,cellular_component ciliary tip;GO:1990075,cellular_component periciliary membrane compartment	NA	kinesin associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:17060]
ENSG00000198900	43.76	41.68	42.97	47.01	42.70	48.84	-0.0972967991202444	6.67778442999746	0.15663086083526	0.516540615182805	20:41028817-41124487:+	TOP1	40;GO:0000228,cellular_component nuclear chromosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003916,molecular_function DNA topoisomerase activity;GO:0003917,molecular_function DNA topoisomerase type I activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006265,biological_process DNA topological change;GO:0006338,biological_process chromatin remodeling;GO:0007059,biological_process chromosome segregation;GO:0007623,biological_process circadian rhythm;GO:0009330,cellular_component DNA topoisomerase complex (ATP-hydrolyzing);GO:0012501,biological_process programmed cell death;GO:0016032,biological_process viral process;GO:0016310,biological_process phosphorylation;GO:0016853,molecular_function isomerase activity;GO:0016925,biological_process protein sumoylation;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019904,molecular_function protein domain specific binding;GO:0031298,cellular_component replication fork protection complex;GO:0032922,biological_process circadian regulation of gene expression;GO:0032993,cellular_component protein-DNA complex;GO:0040016,biological_process embryonic cleavage;GO:0042493,biological_process response to drug;GO:0043204,cellular_component perikaryon;GO:0048511,biological_process rhythmic process;GO:0097100,molecular_function supercoiled DNA binding	NA	topoisomerase (DNA) I [Source:HGNC Symbol%3BAcc:HGNC:11986]
ENSG00000178163	3.99	3.56	3.40	4.11	3.70	4.65	-0.173271099732719	3.67487108494817	0.156701015919577	0.51659053797903	4:10439873-10457410:-	ZNF518B	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 518B [Source:HGNC Symbol%3BAcc:HGNC:29365]
ENSG00000083807	1.36	1.20	1.53	1.05	0.99	1.26	0.331278106015271	1.43830973067097	0.156751453896683	0.51659053797903	19:58479511-58512413:-	SLC27A5	29;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0000166,molecular_function nucleotide binding;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006642,biological_process triglyceride mobilization;GO:0006699,biological_process bile acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008206,biological_process bile acid metabolic process;GO:0009925,cellular_component basal plasma membrane;GO:0015245,molecular_function fatty acid transporter activity;GO:0015721,biological_process bile acid and bile salt transport;GO:0015908,biological_process fatty acid transport;GO:0015911,biological_process plasma membrane long-chain fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0031957,molecular_function very long-chain fatty acid-CoA ligase activity;GO:0032403,molecular_function protein complex binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0046951,biological_process ketone body biosynthetic process;GO:0047747,molecular_function cholate-CoA ligase activity	SLC27A5, FATP5; solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7]; K08748	solute carrier family 27 member 5 [Source:HGNC Symbol%3BAcc:HGNC:10999]
ENSG00000100292	149.92	131.62	156.15	164.82	147.91	162.77	-0.106049893521898	7.04269519069828	0.156770849638847	0.51659053797903	22:35380360-35394214:+	HMOX1	76;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0001935,biological_process endothelial cell proliferation;GO:0002246,biological_process wound healing involved in inflammatory response;GO:0002686,biological_process negative regulation of leukocyte migration;GO:0004392,molecular_function heme oxygenase (decyclizing) activity;GO:0004630,molecular_function phospholipase D activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005901,cellular_component caveola;GO:0006788,biological_process heme oxidation;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007588,biological_process excretion;GO:0008217,biological_process regulation of blood pressure;GO:0008219,biological_process cell death;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010656,biological_process negative regulation of muscle cell apoptotic process;GO:0014806,biological_process smooth muscle hyperplasia;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016491,molecular_function oxidoreductase activity;GO:0019899,molecular_function enzyme binding;GO:0020037,molecular_function heme binding;GO:0031670,biological_process cellular response to nutrient;GO:0032764,biological_process negative regulation of mast cell cytokine production;GO:0034101,biological_process erythrocyte homeostasis;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0034395,biological_process regulation of transcription from RNA polymerase II promoter in response to iron;GO:0034605,biological_process cellular response to heat;GO:0035094,biological_process response to nicotine;GO:0035556,biological_process intracellular signal transduction;GO:0042167,biological_process heme catabolic process;GO:0042168,biological_process heme metabolic process;GO:0042542,biological_process response to hydrogen peroxide;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043305,biological_process negative regulation of mast cell degranulation;GO:0043392,biological_process negative regulation of DNA binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043619,biological_process regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043627,biological_process response to estrogen;GO:0045080,biological_process positive regulation of chemokine biosynthetic process;GO:0045765,biological_process regulation of angiogenesis;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051260,biological_process protein homooligomerization;GO:0055072,biological_process iron ion homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0071276,biological_process cellular response to cadmium ion;GO:0071456,biological_process cellular response to hypoxia;GO:0072719,biological_process cellular response to cisplatin;GO:0097421,biological_process liver regeneration;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1904036,biological_process negative regulation of epithelial cell apoptotic process;GO:1904706,biological_process negative regulation of vascular smooth muscle cell proliferation	HMOX1; heme oxygenase 1 [EC:1.14.14.18]; K00510	heme oxygenase 1 [Source:HGNC Symbol%3BAcc:HGNC:5013]
ENSG00000196693	7.20	6.85	6.53	5.31	7.48	5.51	0.183474533891505	3.97868169239808	0.156959827887195	0.516666075448707	10:42574184-42638568:-	ZNF33B	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 33B [Source:HGNC Symbol%3BAcc:HGNC:13097]
ENSG00000101442	6.86	5.72	6.26	7.40	6.96	6.95	-0.155463295289652	3.63148997480007	0.156995442682951	0.516666075448707	20:38748441-38772520:+	ACTR5	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016579,biological_process protein deubiquitination;GO:0031011,cellular_component Ino80 complex;GO:0070914,biological_process UV-damage excision repair	NA	ARP5 actin related protein 5 homolog [Source:HGNC Symbol%3BAcc:HGNC:14671]
ENSG00000174371	6.93	8.02	7.22	8.44	7.59	8.45	-0.139240873922043	4.31287539837461	0.157034645915758	0.516666075448707	1:241847966-241895148:+	EXO1	35;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0002376,biological_process immune system process;GO:0002455,biological_process humoral immune response mediated by circulating immunoglobulin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0035312,molecular_function 5'-3' exodeoxyribonuclease activity;GO:0045145,molecular_function single-stranded DNA 5'-3' exodeoxyribonuclease activity;GO:0045190,biological_process isotype switching;GO:0046872,molecular_function metal ion binding;GO:0048256,molecular_function flap endonuclease activity;GO:0051321,biological_process meiotic cell cycle;GO:0051908,molecular_function double-stranded DNA 5'-3' exodeoxyribonuclease activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0090656,biological_process t-circle formation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	EXO1; exonuclease 1 [EC:3.1.-.-]; K10746	exonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:3511]
ENSG00000116786	31.70	29.23	32.02	27.92	29.72	30.13	0.0961199896842891	6.52869787736829	0.157043302326557	0.516666075448707	1:15684331-15734769:+	PLEKHM2	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007030,biological_process Golgi organization;GO:0010008,cellular_component endosome membrane;GO:0019894,molecular_function kinesin binding;GO:0032418,biological_process lysosome localization;GO:0032880,biological_process regulation of protein localization;GO:1903527,biological_process positive regulation of membrane tubulation	PLEKHM2, SKIP; pleckstrin homology domain-containing family M member 2; K15348	pleckstrin homology and RUN domain containing M2 [Source:HGNC Symbol%3BAcc:HGNC:29131]
ENSG00000113407	271.57	254.24	266.88	277.94	276.25	292.82	-0.0835855836540443	9.3170515103287	0.157046464634832	0.516666075448707	5:33440695-33469539:+	TARS	16;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004829,molecular_function threonine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006435,biological_process threonyl-tRNA aminoacylation;GO:0015629,cellular_component actin cytoskeleton;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0042803,molecular_function protein homodimerization activity;GO:0043039,biological_process tRNA aminoacylation;GO:0070062,cellular_component extracellular exosome	TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]; K01868	threonyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:11572]
ENSG00000118965	10.01	11.38	10.58	9.42	10.29	10.11	0.10788439978179	5.2068689775626	0.157083624254787	0.516666075448707	2:19910259-19990131:-	WDR35	30;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0009636,biological_process response to toxic substance;GO:0010629,biological_process negative regulation of gene expression;GO:0030030,biological_process cell projection organization;GO:0030991,cellular_component intraciliary transport particle A;GO:0032496,biological_process response to lipopolysaccharide;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0060271,biological_process cilium morphogenesis;GO:0061512,biological_process protein localization to cilium;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097421,biological_process liver regeneration;GO:0097542,cellular_component ciliary tip;GO:0097756,biological_process negative regulation of blood vessel diameter;GO:1901555,biological_process response to paclitaxel;GO:1905705,biological_process cellular response to paclitaxel;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	WD repeat domain 35 [Source:HGNC Symbol%3BAcc:HGNC:29250]
ENSG00000070404	25.89	24.20	27.68	24.43	21.53	25.62	0.133883616430827	4.56624550513796	0.157085134032339	0.516666075448707	19:676364-683399:+	FSTL3	30;GO:0001503,biological_process ossification;GO:0001822,biological_process kidney development;GO:0001968,molecular_function fibronectin binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0008584,biological_process male gonad development;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030141,cellular_component secretory granule;GO:0030324,biological_process lung development;GO:0030325,biological_process adrenal gland development;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0032926,biological_process negative regulation of activin receptor signaling pathway;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0044306,cellular_component neuron projection terminus;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048185,molecular_function activin binding;GO:0071248,biological_process cellular response to metal ion;GO:0090101,biological_process negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	NA	follistatin like 3 [Source:HGNC Symbol%3BAcc:HGNC:3973]
ENSG00000115053	370.74	375.36	350.46	385.72	392.78	391.95	-0.0824169993489836	9.70148983195195	0.157144252794237	0.516683117626733	2:231453530-231483641:-	NCL	24;GO:0001525,biological_process angiogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005938,cellular_component cell cortex;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0042162,molecular_function telomeric DNA binding;GO:0042802,molecular_function identical protein binding;GO:0044547,molecular_function DNA topoisomerase binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070062,cellular_component extracellular exosome;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NCL, NSR1; nucleolin; K11294	nucleolin [Source:HGNC Symbol%3BAcc:HGNC:7667]
ENSG00000140443	4.39	4.36	4.59	3.72	4.42	4.08	0.139618196497328	4.13985253911558	0.157173564179372	0.516683117626733	15:98648970-98964530:+	IGF1R	42;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005010,molecular_function insulin-like growth factor-activated receptor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030335,biological_process positive regulation of cell migration;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0035867,cellular_component alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043235,cellular_component receptor complex;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043559,molecular_function insulin binding;GO:0043560,molecular_function insulin receptor substrate binding;GO:0045740,biological_process positive regulation of DNA replication;GO:0046328,biological_process regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0051262,biological_process protein tetramerization;GO:0051389,biological_process inactivation of MAPKK activity	IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]; K05087	insulin like growth factor 1 receptor [Source:HGNC Symbol%3BAcc:HGNC:5465]
ENSG00000128683	5.88	4.00	5.60	6.12	5.62	6.25	-0.188730252302231	3.48191581411624	0.157250744257375	0.516791985107751	2:170813212-170861151:+	GAD1	33;GO:0003824,molecular_function catalytic activity;GO:0004351,molecular_function glutamate decarboxylase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006538,biological_process glutamate catabolic process;GO:0006540,biological_process glutamate decarboxylation to succinate;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0009449,biological_process gamma-aminobutyric acid biosynthetic process;GO:0012506,cellular_component vesicle membrane;GO:0016595,molecular_function glutamate binding;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0018352,biological_process protein-pyridoxal-5-phosphate linkage;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030424,cellular_component axon;GO:0035176,biological_process social behavior;GO:0035641,biological_process locomotory exploration behavior;GO:0042136,biological_process neurotransmitter biosynthetic process;GO:0042493,biological_process response to drug;GO:0043679,cellular_component axon terminus;GO:0044306,cellular_component neuron projection terminus;GO:0045202,cellular_component synapse;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048786,cellular_component presynaptic active zone;GO:0060077,cellular_component inhibitory synapse;GO:0061202,cellular_component clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	E4.1.1.15, gadB, gadA, GAD; glutamate decarboxylase [EC:4.1.1.15]; K01580	glutamate decarboxylase 1 [Source:HGNC Symbol%3BAcc:HGNC:4092]
ENSG00000174099	12.74	10.27	10.47	10.04	9.29	10.41	0.18931628639081	3.21580129596871	0.157289947614363	0.516791985107751	12:65278642-65488244:+	MSRB3	12;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006979,biological_process response to oxidative stress;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0030091,biological_process protein repair;GO:0033743,molecular_function peptide-methionine (R)-S-oxide reductase activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	methionine sulfoxide reductase B3 [Source:HGNC Symbol%3BAcc:HGNC:27375]
ENSG00000028310	29.20	26.43	27.25	26.05	26.83	25.35	0.098018431893611	5.79548672409171	0.15739728520781	0.516896775765267	5:850290-892824:-	BRD9	8;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0016569,biological_process covalent chromatin modification;GO:0070577,molecular_function lysine-acetylated histone binding	BRD7; bromodomain-containing protein 7; K11723	bromodomain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:25818]
ENSG00000126860	6.54	7.13	8.05	5.97	6.34	6.33	0.230906593532361	2.42583276367057	0.157410822751689	0.516896775765267	17:31317559-31321884:-	EVI2A	4;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ecotropic viral integration site 2A [Source:HGNC Symbol%3BAcc:HGNC:3499]
ENSG00000012983	23.78	24.01	24.35	23.03	22.07	23.24	0.0894978241721918	5.89789643756047	0.157446766226414	0.516896775765267	14:50418500-50561126:-	MAP4K5	12;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0006468,biological_process protein phosphorylation;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	mitogen-activated protein kinase kinase kinase kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:6867]
ENSG00000100147	11.31	12.10	10.50	12.64	12.81	13.20	-0.184727757250538	3.08099562099912	0.157613172507311	0.517306269257868	22:41800678-41826299:+	CCDC134	2;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane	NA	coiled-coil domain containing 134 [Source:HGNC Symbol%3BAcc:HGNC:26185]
ENSG00000062282	2.49	2.46	2.66	2.19	1.82	2.11	0.323844243606063	1.49192209402812	0.157757602495126	0.517643436365848	11:75759511-75801535:+	DGAT2	36;GO:0003846,molecular_function 2-acylglycerol O-acyltransferase activity;GO:0004144,molecular_function diacylglycerol O-acyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0006071,biological_process glycerol metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0019432,biological_process triglyceride biosynthetic process;GO:0019915,biological_process lipid storage;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035336,biological_process long-chain fatty-acyl-CoA metabolic process;GO:0035356,biological_process cellular triglyceride homeostasis;GO:0036155,biological_process acylglycerol acyl-chain remodeling;GO:0042572,biological_process retinol metabolic process;GO:0042632,biological_process cholesterol homeostasis;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045722,biological_process positive regulation of gluconeogenesis;GO:0046322,biological_process negative regulation of fatty acid oxidation;GO:0046339,biological_process diacylglycerol metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050252,molecular_function retinol O-fatty-acyltransferase activity;GO:0050746,biological_process regulation of lipoprotein metabolic process;GO:0055089,biological_process fatty acid homeostasis;GO:0060613,biological_process fat pad development;GO:0071400,biological_process cellular response to oleic acid;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:0097006,biological_process regulation of plasma lipoprotein particle levels	DGAT2; diacylglycerol O-acyltransferase 2 [EC:2.3.1.20 2.3.1.75]; K11160	diacylglycerol O-acyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:16940]
ENSG00000088538	3.97	3.17	4.12	3.73	2.99	3.46	0.164249849431129	4.45883056125367	0.157904568901058	0.517859480444524	3:50675240-51384198:+	DOCK3	7;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0043547,biological_process positive regulation of GTPase activity	NA	dedicator of cytokinesis 3 [Source:HGNC Symbol%3BAcc:HGNC:2989]
ENSG00000013016	1.58	1.91	1.83	2.01	1.89	2.72	-0.3141151010879	1.74646092296859	0.157906882581368	0.517859480444524	2:31234336-31269447:+	EHD3	39;GO:0000166,molecular_function nucleotide binding;GO:0001881,biological_process receptor recycling;GO:0003676,molecular_function nucleic acid binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007596,biological_process blood coagulation;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0020018,cellular_component ciliary pocket membrane;GO:0030030,biological_process cell projection organization;GO:0030139,cellular_component endocytic vesicle;GO:0032456,biological_process endocytic recycling;GO:0034498,biological_process early endosome to Golgi transport;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051260,biological_process protein homooligomerization;GO:0055038,cellular_component recycling endosome membrane;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0072661,biological_process protein targeting to plasma membrane;GO:0086036,biological_process regulation of cardiac muscle cell membrane potential;GO:0090160,biological_process Golgi to lysosome transport;GO:1901387,biological_process positive regulation of voltage-gated calcium channel activity;GO:1903358,biological_process regulation of Golgi organization;GO:1903779,biological_process regulation of cardiac conduction	EHD3; EH domain-containing protein 3; K12476	EH domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:3244]
ENSG00000122696	15.77	15.34	14.13	15.55	11.92	12.94	0.173920061783479	3.68433198095713	0.158125931077089	0.518029339741599	9:37879399-37904353:-	SLC25A51	8;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 51 [Source:HGNC Symbol%3BAcc:HGNC:23323]
ENSG00000119917	29.06	20.47	29.09	29.14	25.45	35.66	-0.182773547116903	5.38888561355516	0.158146047183913	0.518029339741599	10:89327893-89340971:+	IFIT3	14;GO:0002376,biological_process immune system process;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009615,biological_process response to virus;GO:0035457,biological_process cellular response to interferon-alpha;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045087,biological_process innate immune response;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway	NA	interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol%3BAcc:HGNC:5411]
ENSG00000176903	168.06	140.42	165.34	175.20	159.13	181.67	-0.109860457247824	7.45194291504351	0.158150674446105	0.518029339741599	14:73711782-73714372:-	PNMA1	6;GO:0002437,biological_process inflammatory response to antigenic stimulus;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0043065,biological_process positive regulation of apoptotic process	NA	paraneoplastic Ma antigen 1 [Source:HGNC Symbol%3BAcc:HGNC:9158]
ENSG00000171631	9.12	10.97	9.13	8.14	7.55	9.79	0.195282170198078	3.18317473628942	0.158157400025081	0.518029339741599	11:73264504-73298617:+	P2RY6	19;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030321,biological_process transepithelial chloride transport;GO:0035589,biological_process G-protein coupled purinergic nucleotide receptor signaling pathway;GO:0045028,molecular_function G-protein coupled purinergic nucleotide receptor activity;GO:0045029,molecular_function UDP-activated nucleotide receptor activity;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071407,biological_process cellular response to organic cyclic compound	P2RY6; P2Y purinoceptor 6; K04272	pyrimidinergic receptor P2Y6 [Source:HGNC Symbol%3BAcc:HGNC:8543]
ENSG00000138623	11.21	8.71	10.68	10.19	6.04	10.07	0.233019088276539	4.26139805760402	0.158194035539672	0.518029339741599	15:74409288-74434467:-	SEMA7A	23;GO:0001649,biological_process osteoblast differentiation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0021988,biological_process olfactory lobe development;GO:0030154,biological_process cell differentiation;GO:0031175,biological_process neuron projection development;GO:0031225,cellular_component anchored component of membrane;GO:0038191,molecular_function neuropilin binding;GO:0045773,biological_process positive regulation of axon extension;GO:0048675,biological_process axon extension;GO:0050727,biological_process regulation of inflammatory response;GO:0050919,biological_process negative chemotaxis;GO:0060907,biological_process positive regulation of macrophage cytokine production;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade	SEMA7, CD108; semaphorin 7; K06529	semaphorin 7A (John Milton Hagen blood group) [Source:HGNC Symbol%3BAcc:HGNC:10741]
ENSG00000178605	32.07	26.05	28.43	30.81	32.97	30.84	-0.111421219132821	5.55508086045853	0.158209073307049	0.518029339741599	X:304528-318819:-	GTPBP6	1;GO:0005525,molecular_function GTP binding	NA	GTP binding protein 6 (putative) [Source:HGNC Symbol%3BAcc:HGNC:30189]
ENSG00000168564	7.10	8.67	6.76	8.47	8.32	8.52	-0.168818110440121	3.80773845376184	0.158276048632265	0.518111970377716	4:183444590-183448198:+	CDKN2AIP	12;GO:0001652,cellular_component granular component;GO:0002039,molecular_function p53 binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009967,biological_process positive regulation of signal transduction;GO:0030307,biological_process positive regulation of cell growth;GO:0030308,biological_process negative regulation of cell growth;GO:0031647,biological_process regulation of protein stability	NA	CDKN2A interacting protein [Source:HGNC Symbol%3BAcc:HGNC:24325]
ENSG00000176720	20.32	24.19	23.96	24.49	24.45	27.64	-0.157131377540907	3.95705280222483	0.158395924357229	0.518286380635705	2:241551423-241574138:+	BOK	53;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006921,biological_process cellular component disassembly involved in execution phase of apoptosis;GO:0007420,biological_process brain development;GO:0008283,biological_process cell proliferation;GO:0008584,biological_process male gonad development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031901,cellular_component early endosome membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0033106,cellular_component cis-Golgi network membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048709,biological_process oligodendrocyte differentiation;GO:0051259,biological_process protein oligomerization;GO:0051400,molecular_function BH domain binding;GO:0051402,biological_process neuron apoptotic process;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0051902,biological_process negative regulation of mitochondrial depolarization;GO:0055038,cellular_component recycling endosome membrane;GO:0060546,biological_process negative regulation of necroptotic process;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1900119,biological_process positive regulation of execution phase of apoptosis;GO:1901029,biological_process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1901382,biological_process regulation of chorionic trophoblast cell proliferation;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903899,biological_process positive regulation of PERK-mediated unfolded protein response;GO:1904708,biological_process regulation of granulosa cell apoptotic process;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BOK; Bcl-2-related ovarian killer protein; K02561	BOK%2C BCL2 family apoptosis regulator [Source:HGNC Symbol%3BAcc:HGNC:1087]
ENSG00000131183	0.49	0.48	0.59	0.60	0.83	0.74	-0.453178658247516	0.491195067666692	0.158437337276201	0.518286380635705	5:177379234-177398848:+	SLC34A1	60;GO:0001503,biological_process ossification;GO:0001822,biological_process kidney development;GO:0005436,molecular_function sodium:phosphate symporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006817,biological_process phosphate ion transport;GO:0007584,biological_process response to nutrient;GO:0009100,biological_process glycoprotein metabolic process;GO:0009986,cellular_component cell surface;GO:0010288,biological_process response to lead ion;GO:0015293,molecular_function symporter activity;GO:0015321,molecular_function sodium-dependent phosphate transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030165,molecular_function PDZ domain binding;GO:0030643,biological_process cellular phosphate ion homeostasis;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031526,cellular_component brush border membrane;GO:0031982,cellular_component vesicle;GO:0032026,biological_process response to magnesium ion;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0033189,biological_process response to vitamin A;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0035864,biological_process response to potassium ion;GO:0042431,biological_process indole metabolic process;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043434,biological_process response to peptide hormone;GO:0044267,biological_process cellular protein metabolic process;GO:0044341,biological_process sodium-dependent phosphate transport;GO:0045121,cellular_component membrane raft;GO:0045838,biological_process positive regulation of membrane potential;GO:0046686,biological_process response to cadmium ion;GO:0046689,biological_process response to mercury ion;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051260,biological_process protein homooligomerization;GO:0055062,biological_process phosphate ion homeostasis;GO:0060416,biological_process response to growth hormone;GO:0071107,biological_process response to parathyroid hormone;GO:0071248,biological_process cellular response to metal ion;GO:0071374,biological_process cellular response to parathyroid hormone stimulus;GO:0072350,biological_process tricarboxylic acid metabolic process;GO:0072734,biological_process cellular response to staurosporine;GO:0097066,biological_process response to thyroid hormone;GO:0097187,biological_process dentinogenesis;GO:1901128,biological_process gentamycin metabolic process;GO:1901652,biological_process response to peptide;GO:1901684,biological_process arsenate ion transmembrane transport;GO:2000120,biological_process positive regulation of sodium-dependent phosphate transport;GO:2000187,biological_process positive regulation of phosphate transmembrane transport	SLC34A, NPT, nptA; solute carrier family 34 (sodium-dependent phosphate cotransporter); K14683	solute carrier family 34 member 1 [Source:HGNC Symbol%3BAcc:HGNC:11019]
ENSG00000265681	20.11	18.19	16.11	22.12	18.49	21.52	-0.179472401182139	3.4722169512462	0.158454589101144	0.518286380635705	18:49488452-49492523:-	RPL17	16;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015934,cellular_component large ribosomal subunit;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	ribosomal protein L17 [Source:HGNC Symbol%3BAcc:HGNC:10307]
ENSG00000112029	32.86	34.49	30.74	35.57	36.37	34.14	-0.103808994575682	5.51676123667559	0.158576594786143	0.518380971094069	6:152970518-152983579:-	FBXO5	26;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0001556,biological_process oocyte maturation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007057,biological_process spindle assembly involved in female meiosis I;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016050,biological_process vesicle organization;GO:0019901,molecular_function protein kinase binding;GO:0040020,biological_process regulation of meiotic nuclear division;GO:0045835,biological_process negative regulation of meiotic nuclear division;GO:0046785,biological_process microtubule polymerization;GO:0046872,molecular_function metal ion binding;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity;GO:1990948,molecular_function ubiquitin ligase inhibitor activity	FBXO5, EMI1; F-box protein 5; K10292	F-box protein 5 [Source:HGNC Symbol%3BAcc:HGNC:13584]
ENSG00000167377	12.54	11.15	12.16	11.68	10.60	11.00	0.124736152392521	4.56586981145146	0.15858736209433	0.518380971094069	16:71447596-71463095:-	ZNF23	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 23 [Source:HGNC Symbol%3BAcc:HGNC:13023]
ENSG00000006451	133.63	107.70	119.63	140.36	118.22	137.73	-0.120507852002222	6.31902732791502	0.158652460358061	0.518380971094069	7:39623482-39708124:+	RALA	35;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0001843,biological_process neural tube closure;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006887,biological_process exocytosis;GO:0006935,biological_process chemotaxis;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0017022,molecular_function myosin binding;GO:0017157,biological_process regulation of exocytosis;GO:0019003,molecular_function GDP binding;GO:0030139,cellular_component endocytic vesicle;GO:0030496,cellular_component midbody;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031755,molecular_function Edg-2 lysophosphatidic acid receptor binding;GO:0032154,cellular_component cleavage furrow;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043209,cellular_component myelin sheath;GO:0051117,molecular_function ATPase binding;GO:0051301,biological_process cell division;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051665,biological_process membrane raft localization;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	RALA; Ras-related protein Ral-A; K07834	RAS like proto-oncogene A [Source:HGNC Symbol%3BAcc:HGNC:9839]
ENSG00000023902	18.13	14.10	15.66	14.77	14.65	14.27	0.153254257542772	4.24293903130643	0.158721300017769	0.518380971094069	1:150149182-150164720:+	PLEKHO1	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007520,biological_process myoblast fusion;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0032587,cellular_component ruffle membrane;GO:0036195,cellular_component muscle cell projection membrane;GO:0051451,biological_process myoblast migration;GO:0072673,biological_process lamellipodium morphogenesis	NA	pleckstrin homology domain containing O1 [Source:HGNC Symbol%3BAcc:HGNC:24310]
ENSG00000156587	140.83	120.63	158.67	180.90	131.64	159.78	-0.155212297384136	6.24331050667759	0.158733138600346	0.518380971094069	11:57551655-57568284:-	UBE2L6	17;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0019941,biological_process modification-dependent protein catabolic process;GO:0019985,biological_process translesion synthesis;GO:0032020,biological_process ISG15-protein conjugation;GO:0032480,biological_process negative regulation of type I interferon production;GO:0042296,molecular_function ISG15 transferase activity;GO:0043130,molecular_function ubiquitin binding;GO:0044267,biological_process cellular protein metabolic process	UBE2L6, UBCH8; ubiquitin-conjugating enzyme E2 L6 [EC:2.3.2.23]; K04553	ubiquitin conjugating enzyme E2 L6 [Source:HGNC Symbol%3BAcc:HGNC:12490]
ENSG00000274211	3.85	3.62	5.19	3.78	3.31	3.79	0.238165785854328	2.81017870691582	0.158734074851249	0.518380971094069	17:38352227-38405593:+	SOCS7	21;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008150,biological_process biological_process;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0017124,molecular_function SH3 domain binding;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0021819,biological_process layer formation in cerebral cortex;GO:0021942,biological_process radial glia guided migration of Purkinje cell;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0045444,biological_process fat cell differentiation;GO:0046426,biological_process negative regulation of JAK-STAT cascade	SOCS6_7; suppressor of cytokine signaling 6/7; K04699	suppressor of cytokine signaling 7 [Source:HGNC Symbol%3BAcc:HGNC:29846]
ENSG00000158714	1.24	0.89	0.95	0.53	0.18	1.23	0.661599672550703	-0.194699752959548	0.158902800076268	0.518734505513408	1:159826749-159837249:+	SLAMF8	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	SLAM family member 8 [Source:HGNC Symbol%3BAcc:HGNC:21391]
ENSG00000134253	2.89	4.29	3.14	2.86	2.73	3.08	0.241303507840506	2.53667985778101	0.158928656681606	0.518734505513408	1:117111059-117122587:-	TRIM45	9;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding;GO:0060348,biological_process bone development	NA	tripartite motif containing 45 [Source:HGNC Symbol%3BAcc:HGNC:19018]
ENSG00000128805	7.23	6.42	7.19	6.91	5.80	6.39	0.142541294710397	4.22660608893316	0.158967699909208	0.518734505513408	10:48446033-48656265:-	ARHGAP22	14;GO:0001525,biological_process angiogenesis;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 22 [Source:HGNC Symbol%3BAcc:HGNC:30320]
ENSG00000182253	4.48	5.50	4.67	3.97	4.81	4.49	0.145953887849347	4.45454821252651	0.159220005891215	0.519014673249132	15:99098216-99135593:+	SYNM	18;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0005912,cellular_component adherens junction;GO:0008307,molecular_function structural constituent of muscle;GO:0016020,cellular_component membrane;GO:0017166,molecular_function vinculin binding;GO:0019215,molecular_function intermediate filament binding;GO:0030054,cellular_component cell junction;GO:0031443,biological_process fast-twitch skeletal muscle fiber contraction;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0060053,cellular_component neurofilament cytoskeleton	NA	synemin [Source:HGNC Symbol%3BAcc:HGNC:24466]
ENSG00000185088	105.27	99.17	100.38	94.45	92.61	99.51	0.102082563890833	5.1996833115109	0.159223899061331	0.519014673249132	15:63125871-63158021:-	RPS27L	19;GO:0000028,biological_process ribosomal small subunit assembly;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005840,cellular_component ribosome;GO:0006281,biological_process DNA repair;GO:0006412,biological_process translation;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0008494,molecular_function translation activator activity;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045727,biological_process positive regulation of translation;GO:0046872,molecular_function metal ion binding	RP-S27e, RPS27; small subunit ribosomal protein S27e; K02978	ribosomal protein S27 like [Source:HGNC Symbol%3BAcc:HGNC:18476]
ENSG00000196345	0.82	0.58	1.14	0.90	1.37	1.09	-0.365159284605676	1.30311318400813	0.159321265906076	0.519014673249132	3:44555192-44594173:+	ZKSCAN7	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger with KRAB and SCAN domains 7 [Source:HGNC Symbol%3BAcc:HGNC:12955]
ENSG00000088247	90.05	88.85	88.06	96.19	97.24	91.96	-0.0845050246204973	7.77620106280805	0.159328747816143	0.519014673249132	19:6413347-6424794:-	KHSRP	28;GO:0000178,cellular_component exosome (RNase complex);GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006402,biological_process mRNA catabolic process;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010586,biological_process miRNA metabolic process;GO:0016020,cellular_component membrane;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0043488,biological_process regulation of mRNA stability;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0051028,biological_process mRNA transport;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0071345,biological_process cellular response to cytokine stimulus;GO:2000628,biological_process regulation of miRNA metabolic process	NA	KH-type splicing regulatory protein [Source:HGNC Symbol%3BAcc:HGNC:6316]
ENSG00000107874	58.73	52.94	56.50	52.52	49.77	55.78	0.103638171746394	5.55566794704065	0.159377102227813	0.519014673249132	10:102423244-102432661:-	CUEDC2	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010936,biological_process negative regulation of macrophage cytokine production;GO:0031965,cellular_component nuclear membrane;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response	NA	CUE domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28352]
ENSG00000159167	25.35	24.12	22.45	22.33	20.16	23.25	0.139855994213829	4.10056641011942	0.159418575563812	0.519014673249132	8:23841914-23854807:-	STC1	26;GO:0001503,biological_process ossification;GO:0001886,biological_process endothelial cell morphogenesis;GO:0003421,biological_process growth plate cartilage axis specification;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007566,biological_process embryo implantation;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0014070,biological_process response to organic cyclic compound;GO:0016324,cellular_component apical plasma membrane;GO:0030336,biological_process negative regulation of cell migration;GO:0033280,biological_process response to vitamin D;GO:0035988,biological_process chondrocyte proliferation;GO:0044070,biological_process regulation of anion transport;GO:0046697,biological_process decidualization;GO:0051926,biological_process negative regulation of calcium ion transport;GO:0060348,biological_process bone development;GO:0071320,biological_process cellular response to cAMP;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:0090280,biological_process positive regulation of calcium ion import;GO:1903403,biological_process negative regulation of renal phosphate excretion	NA	stanniocalcin 1 [Source:HGNC Symbol%3BAcc:HGNC:11373]
ENSG00000103126	14.72	14.78	16.09	17.64	15.32	16.65	-0.109164710029464	5.39797942515009	0.159441112611578	0.519014673249132	16:287439-352673:-	AXIN1	64;GO:0001743,biological_process optic placode formation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004871,molecular_function signal transducer activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007257,biological_process activation of JUN kinase activity;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0008013,molecular_function beta-catenin binding;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016328,cellular_component lateral plasma membrane;GO:0016579,biological_process protein deubiquitination;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0021797,biological_process forebrain anterior/posterior pattern specification;GO:0021881,biological_process Wnt-activated signaling pathway involved in forebrain neuron fate commitment;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030877,cellular_component beta-catenin destruction complex;GO:0030910,biological_process olfactory placode formation;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032147,biological_process activation of protein kinase activity;GO:0032947,molecular_function protein complex scaffold;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043623,biological_process cellular protein complex assembly;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046332,molecular_function SMAD binding;GO:0048048,biological_process embryonic eye morphogenesis;GO:0048320,biological_process axial mesoderm formation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0055001,biological_process muscle cell development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060272,biological_process embryonic skeletal joint morphogenesis;GO:0060823,biological_process canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0070016,molecular_function armadillo repeat domain binding;GO:0070411,molecular_function I-SMAD binding;GO:0071944,cellular_component cell periphery;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1904885,biological_process beta-catenin destruction complex assembly;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	AXIN1; axin 1; K02157	axin 1 [Source:HGNC Symbol%3BAcc:HGNC:903]
ENSG00000085449	35.89	35.35	33.75	38.47	36.56	38.13	-0.0972365294664818	5.48911474482543	0.159442438352697	0.519014673249132	2:223855715-223945387:-	WDFY1	11;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005634,cellular_component nucleus;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0034141,biological_process positive regulation of toll-like receptor 3 signaling pathway;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0046872,molecular_function metal ion binding	NA	WD repeat and FYVE domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20451]
ENSG00000180881	1.98	1.63	1.48	1.73	1.14	1.20	0.341181376578123	1.67476923946138	0.159478635930891	0.519014673249132	12:75275978-75390928:-	CAPS2	5;GO:0005432,molecular_function calcium:sodium antiporter activity;GO:0005509,molecular_function calcium ion binding;GO:0035725,biological_process sodium ion transmembrane transport;GO:0046872,molecular_function metal ion binding;GO:0055074,biological_process calcium ion homeostasis	NA	calcyphosine 2 [Source:HGNC Symbol%3BAcc:HGNC:16471]
ENSG00000067715	2.57	2.11	1.45	2.25	0.78	1.44	0.464812672321503	1.2522078535262	0.159530196640995	0.519014673249132	12:78863992-79452008:+	SYT1	73;GO:0000149,molecular_function SNARE binding;GO:0001786,molecular_function phosphatidylserine binding;GO:0005509,molecular_function calcium ion binding;GO:0005513,biological_process detection of calcium ion;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005543,molecular_function phospholipid binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006906,biological_process vesicle fusion;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0007420,biological_process brain development;GO:0008021,cellular_component synaptic vesicle;GO:0008022,molecular_function protein C-terminus binding;GO:0014047,biological_process glutamate secretion;GO:0014059,biological_process regulation of dopamine secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0017075,molecular_function syntaxin-1 binding;GO:0017157,biological_process regulation of exocytosis;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030141,cellular_component secretory granule;GO:0030154,biological_process cell differentiation;GO:0030276,molecular_function clathrin binding;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0030348,molecular_function syntaxin-3 binding;GO:0030424,cellular_component axon;GO:0030658,cellular_component transport vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031045,cellular_component dense core granule;GO:0031201,cellular_component SNARE complex;GO:0031340,biological_process positive regulation of vesicle fusion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042584,cellular_component chromaffin granule membrane;GO:0042734,cellular_component presynaptic membrane;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043195,cellular_component terminal bouton;GO:0043229,cellular_component intracellular organelle;GO:0044306,cellular_component neuron projection terminus;GO:0045202,cellular_component synapse;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048278,biological_process vesicle docking;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0050806,biological_process positive regulation of synaptic transmission;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization;GO:0051592,biological_process response to calcium ion;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060076,cellular_component excitatory synapse;GO:0060201,cellular_component clathrin-sculpted acetylcholine transport vesicle membrane;GO:0060203,cellular_component clathrin-sculpted glutamate transport vesicle membrane;GO:0061024,biological_process membrane organization;GO:0061202,cellular_component clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0070083,cellular_component clathrin-sculpted monoamine transport vesicle membrane;GO:0071277,biological_process cellular response to calcium ion;GO:0098746,biological_process fast, calcium ion-dependent exocytosis of neurotransmitter;GO:1903305,biological_process regulation of regulated secretory pathway;GO:1903861,biological_process positive regulation of dendrite extension	SYT1; synaptotagmin-1; K15290	synaptotagmin 1 [Source:HGNC Symbol%3BAcc:HGNC:11509]
ENSG00000204539	1.07	1.02	1.30	1.09	2.10	1.37	-0.403935124327044	1.1805862872666	0.159594318469866	0.519014673249132	6:31115089-31120446:-	CDSN	2;GO:0005615,cellular_component extracellular space;GO:0043589,biological_process skin morphogenesis	NA	corneodesmosin [Source:HGNC Symbol%3BAcc:HGNC:1802]
ENSG00000101972	32.39	32.00	34.52	35.02	34.96	36.08	-0.0882142878955439	7.04405645874704	0.159624588268779	0.519014673249132	X:123960211-124422664:+	STAG2	17;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0008278,cellular_component cohesin complex;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0032876,biological_process negative regulation of DNA endoreduplication;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0097431,cellular_component mitotic spindle pole	STAG1_2, SCC3, IRR1; cohesin complex subunit SA-1/2; K06671	stromal antigen 2 [Source:HGNC Symbol%3BAcc:HGNC:11355]
ENSG00000163913	11.91	13.13	12.59	11.28	12.33	11.76	0.0989560110695179	5.64295579432224	0.159625171316706	0.519014673249132	3:129440035-129520507:+	IFT122	37;GO:0001843,biological_process neural tube closure;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007227,biological_process signal transduction downstream of smoothened;GO:0007275,biological_process multicellular organism development;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010172,biological_process embryonic body morphogenesis;GO:0016020,cellular_component membrane;GO:0021914,biological_process negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning;GO:0030030,biological_process cell projection organization;GO:0030991,cellular_component intraciliary transport particle A;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035050,biological_process embryonic heart tube development;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035720,biological_process intraciliary anterograde transport;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060173,biological_process limb development;GO:0060271,biological_process cilium morphogenesis;GO:0060830,biological_process ciliary receptor clustering involved in smoothened signaling pathway;GO:0060831,biological_process smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0060971,biological_process embryonic heart tube left/right pattern formation;GO:0061512,biological_process protein localization to cilium;GO:0072594,biological_process establishment of protein localization to organelle;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:1905515,biological_process non-motile cilium assembly	NA	intraflagellar transport 122 [Source:HGNC Symbol%3BAcc:HGNC:13556]
ENSG00000157823	1.91	1.69	1.47	1.50	0.98	1.24	0.456017050371063	0.478795897816368	0.159638928741254	0.519014673249132	15:89830598-89894638:-	AP3S2	15;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008089,biological_process anterograde axonal transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:1904115,cellular_component axon cytoplasm	AP3S; AP-3 complex subunit sigma; K12399	adaptor related protein complex 3 sigma 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:571]
ENSG00000101017	33.51	25.38	33.58	41.13	31.51	32.49	-0.166759856087511	4.8730787439929	0.159983266083155	0.519997979023359	20:46118271-46129863:+	CD40	63;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0002768,biological_process immune response-regulating cell surface receptor signaling pathway;GO:0003823,molecular_function antigen binding;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007275,biological_process multicellular organism development;GO:0009617,biological_process response to bacterium;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030168,biological_process platelet activation;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031667,biological_process response to nutrient levels;GO:0032496,biological_process response to lipopolysaccharide;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033590,biological_process response to cobalamin;GO:0034341,biological_process response to interferon-gamma;GO:0035631,cellular_component CD40 receptor complex;GO:0036018,biological_process cellular response to erythropoietin;GO:0042100,biological_process B cell proliferation;GO:0042113,biological_process B cell activation;GO:0042127,biological_process regulation of cell proliferation;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042832,biological_process defense response to protozoan;GO:0043025,cellular_component neuronal cell body;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043196,cellular_component varicosity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043491,biological_process protein kinase B signaling;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048304,biological_process positive regulation of isotype switching to IgG isotypes;GO:0050776,biological_process regulation of immune response;GO:0051023,biological_process regulation of immunoglobulin secretion;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0070062,cellular_component extracellular exosome;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0090037,biological_process positive regulation of protein kinase C signaling;GO:0097190,biological_process apoptotic signaling pathway;GO:1901652,biological_process response to peptide;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process	TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5; K03160	CD40 molecule [Source:HGNC Symbol%3BAcc:HGNC:11919]
ENSG00000132591	35.60	32.98	32.73	34.72	38.12	36.68	-0.0988959504989364	5.59031659217976	0.160114325693285	0.520287729013285	17:28854937-28861067:+	ERAL1	16;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0019843,molecular_function rRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0043024,molecular_function ribosomal small subunit binding;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	Era like 12S mitochondrial rRNA chaperone 1 [Source:HGNC Symbol%3BAcc:HGNC:3424]
ENSG00000167371	2.50	2.26	2.78	2.18	1.97	2.05	0.303221469035569	1.61601806447117	0.160169098111404	0.520329498784837	16:29811381-29815892:+	PRRT2	9;GO:0005886,cellular_component plasma membrane;GO:0009607,biological_process response to biotic stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030054,cellular_component cell junction;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0050884,biological_process neuromuscular process controlling posture	NA	proline rich transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:30500]
ENSG00000105671	19.96	19.74	20.56	22.58	21.93	20.93	-0.105669950889449	5.00642533506901	0.160240668652696	0.52042580324069	19:18919674-18928633:+	DDX49	12;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016787,molecular_function hydrolase activity	NA	DEAD-box helicase 49 [Source:HGNC Symbol%3BAcc:HGNC:18684]
ENSG00000035499	6.96	6.43	6.23	7.42	7.65	7.01	-0.155307070515505	3.55435865118936	0.160288031723721	0.520443457438281	5:60596911-60700190:-	DEPDC1B	8;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0016477,biological_process cell migration;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	DEP domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:24902]
ENSG00000104904	501.70	526.70	492.97	487.61	479.78	481.03	0.0823432463434571	8.82759059477227	0.160365158586349	0.52055771797394	19:2269508-2273490:+	OAZ1	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0006810,biological_process transport;GO:0008073,molecular_function ornithine decarboxylase inhibitor activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:1902268,biological_process negative regulation of polyamine transmembrane transport	NA	ornithine decarboxylase antizyme 1 [Source:HGNC Symbol%3BAcc:HGNC:8095]
ENSG00000116005	48.39	52.61	51.11	46.65	50.66	46.04	0.0958551819695543	6.22387493138116	0.160481699821483	0.520629366295083	2:70257385-70281191:+	PCYOX1	16;GO:0001735,molecular_function prenylcysteine oxidase activity;GO:0005764,cellular_component lysosome;GO:0005774,cellular_component vacuolar membrane;GO:0005886,cellular_component plasma membrane;GO:0006821,biological_process chloride transport;GO:0008555,molecular_function chloride-transporting ATPase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016670,molecular_function oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor;GO:0030327,biological_process prenylated protein catabolic process;GO:0030328,biological_process prenylcysteine catabolic process;GO:0030329,biological_process prenylcysteine metabolic process;GO:0034361,cellular_component very-low-density lipoprotein particle;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	PCYOX1, FCLY; prenylcysteine oxidase / farnesylcysteine lyase [EC:1.8.3.5 1.8.3.6]; K05906	prenylcysteine oxidase 1 [Source:HGNC Symbol%3BAcc:HGNC:20588]
ENSG00000213339	26.58	27.02	29.02	31.29	29.64	28.60	-0.102989748615025	5.37855321786307	0.160497102561908	0.520629366295083	19:10701429-10713437:+	QTRT1	16;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008479,molecular_function queuine tRNA-ribosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016763,molecular_function transferase activity, transferring pentosyl groups;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0101030,biological_process tRNA-guanine transglycosylation	NA	queuine tRNA-ribosyltransferase catalytic subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:23797]
ENSG00000111605	36.36	38.24	34.17	33.29	34.72	34.58	0.0936408389903464	6.00702628480893	0.16051305766626	0.520629366295083	12:69239536-69274358:+	CPSF6	14;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005849,cellular_component mRNA cleavage factor complex;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042382,cellular_component paraspeckles;GO:0051262,biological_process protein tetramerization	CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7; K14398	cleavage and polyadenylation specific factor 6 [Source:HGNC Symbol%3BAcc:HGNC:13871]
ENSG00000139644	777.04	783.47	774.50	852.35	799.28	838.62	-0.0811317869858559	9.48931646493664	0.160802968635939	0.521061393027052	12:49707724-49764934:+	TMBIM6	29;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006986,biological_process response to unfolded protein;GO:0010523,biological_process negative regulation of calcium ion transport into cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032091,biological_process negative regulation of protein binding;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043066,biological_process negative regulation of apoptotic process;GO:0051025,biological_process negative regulation of immunoglobulin secretion;GO:0060698,molecular_function endoribonuclease inhibitor activity;GO:0060702,biological_process negative regulation of endoribonuclease activity;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1902065,biological_process response to L-glutamate;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903298,biological_process negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:1904721,biological_process negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response;GO:1990441,biological_process negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	NA	transmembrane BAX inhibitor motif containing 6 [Source:HGNC Symbol%3BAcc:HGNC:11723]
ENSG00000138834	27.82	24.21	29.34	25.85	23.09	26.91	0.114907411597212	6.71994040982041	0.160835725934493	0.521061393027052	16:1706182-1770317:+	MAPK8IP3	30;GO:0000139,cellular_component Golgi membrane;GO:0001701,biological_process in utero embryonic development;GO:0005078,molecular_function MAP-kinase scaffold activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0007254,biological_process JNK cascade;GO:0007257,biological_process activation of JUN kinase activity;GO:0007411,biological_process axon guidance;GO:0007585,biological_process respiratory gaseous exchange;GO:0008104,biological_process protein localization;GO:0008432,molecular_function JUN kinase binding;GO:0009791,biological_process post-embryonic development;GO:0010468,biological_process regulation of gene expression;GO:0016192,biological_process vesicle-mediated transport;GO:0019894,molecular_function kinesin binding;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030425,cellular_component dendrite;GO:0030673,cellular_component axolemma;GO:0030900,biological_process forebrain development;GO:0031175,biological_process neuron projection development;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0043005,cellular_component neuron projection;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0046328,biological_process regulation of JNK cascade;GO:0048286,biological_process lung alveolus development;GO:0060425,biological_process lung morphogenesis	MAPK8IP3, JIP3; mitogen-activated protein kinase 8 interacting protein 3; K04436	mitogen-activated protein kinase 8 interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:6884]
ENSG00000132475	496.22	464.01	498.80	539.29	478.66	556.61	-0.0976914645807148	7.97814996889154	0.160882614814886	0.521061393027052	17:75776433-75785893:-	H3F3B	45;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000228,cellular_component nuclear chromosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000786,cellular_component nucleosome;GO:0000788,cellular_component nuclear nucleosome;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001649,biological_process osteoblast differentiation;GO:0001740,cellular_component Barr body;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006334,biological_process nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006997,biological_process nucleus organization;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0007338,biological_process single fertilization;GO:0007566,biological_process embryo implantation;GO:0007596,biological_process blood coagulation;GO:0008283,biological_process cell proliferation;GO:0008584,biological_process male gonad development;GO:0030307,biological_process positive regulation of cell growth;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031508,biological_process pericentric heterochromatin assembly;GO:0031509,biological_process telomeric heterochromatin assembly;GO:0032200,biological_process telomere organization;GO:0035264,biological_process multicellular organism growth;GO:0042393,molecular_function histone binding;GO:0042692,biological_process muscle cell differentiation;GO:0043234,cellular_component protein complex;GO:0044267,biological_process cellular protein metabolic process;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046982,molecular_function protein heterodimerization activity;GO:0048477,biological_process oogenesis;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070062,cellular_component extracellular exosome;GO:0090230,biological_process regulation of centromere complex assembly;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1902340,biological_process negative regulation of chromosome condensation	H3; histone H3; K11253	H3 histone family member 3B [Source:HGNC Symbol%3BAcc:HGNC:4765]
ENSG00000186973	5.58	4.16	3.78	4.14	2.85	3.47	0.389291477184103	1.12333574628807	0.160891626820378	0.521061393027052	1:43145152-43156396:+	FAM183A	NA	NA	family with sequence similarity 183 member A [Source:HGNC Symbol%3BAcc:HGNC:34347]
ENSG00000269113	16.76	14.66	17.04	14.77	15.65	14.51	0.128227923193936	4.60513412239342	0.160897999827501	0.521061393027052	1:47760527-47996895:-	TRABD2B	18;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016787,molecular_function hydrolase activity;GO:0017147,molecular_function Wnt-protein binding;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0031301,cellular_component integral component of organelle membrane;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1904808,biological_process positive regulation of protein oxidation	NA	TraB domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:44200]
ENSG00000100603	74.13	68.23	65.65	77.45	71.59	75.12	-0.0956738944744648	6.95015198916465	0.160961990223509	0.521061393027052	14:77717598-77761207:-	SNW1	49;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000350,biological_process generation of catalytic spliceosome for second transesterification step;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000785,cellular_component chromatin;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005112,molecular_function Notch binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0007219,biological_process Notch signaling pathway;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0008380,biological_process RNA splicing;GO:0014010,biological_process Schwann cell proliferation;GO:0016032,biological_process viral process;GO:0016363,cellular_component nuclear matrix;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0019899,molecular_function enzyme binding;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042809,molecular_function vitamin D receptor binding;GO:0042974,molecular_function retinoic acid receptor binding;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0048385,biological_process regulation of retinoic acid receptor signaling pathway;GO:0050681,molecular_function androgen receptor binding;GO:0050769,biological_process positive regulation of neurogenesis;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0070562,biological_process regulation of vitamin D receptor signaling pathway;GO:0070564,biological_process positive regulation of vitamin D receptor signaling pathway;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071014,cellular_component post-mRNA release spliceosomal complex;GO:0071141,cellular_component SMAD protein complex;GO:0071146,cellular_component SMAD3-SMAD4 protein complex;GO:0071300,biological_process cellular response to retinoic acid	SNW1, SKIIP, SKIP; SNW domain-containing protein 1; K06063	SNW domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16696]
ENSG00000130309	85.65	92.03	82.28	79.13	87.51	77.85	0.0993737922505258	7.29516823915248	0.16096807859886	0.521061393027052	19:17555593-17583162:+	COLGALT1	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0050211,molecular_function procollagen galactosyltransferase activity	GLT25D; collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]; K11703	collagen beta(1-O)galactosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:26182]
ENSG00000204681	13.26	11.69	14.66	12.80	11.64	12.36	0.123280739271676	5.33339968867029	0.16098207059202	0.521061393027052	6:29555628-29633976:-	GABBR1	24;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004965,molecular_function G-protein coupled GABA receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007194,biological_process negative regulation of adenylate cyclase activity;GO:0007214,biological_process gamma-aminobutyric acid signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0038037,cellular_component G-protein coupled receptor dimeric complex;GO:0038039,cellular_component G-protein coupled receptor heterodimeric complex;GO:0042734,cellular_component presynaptic membrane;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0098793,cellular_component presynapse	GABBR; gamma-aminobutyric acid type B receptor; K04615	gamma-aminobutyric acid type B receptor subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4070]
ENSG00000179454	4.23	3.87	3.82	4.44	4.15	5.21	-0.200079602602665	2.9457214373429	0.161245469055507	0.521648400626613	14:44924318-45042322:-	KLHL28	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch like family member 28 [Source:HGNC Symbol%3BAcc:HGNC:19741]
ENSG00000168264	78.97	74.24	84.38	76.96	66.84	78.70	0.10726812695654	7.08035699410039	0.161247475485726	0.521648400626613	1:234604268-234609525:-	IRF2BP2	6;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	interferon regulatory factor 2 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:21729]
ENSG00000157870	3.73	4.54	3.79	2.77	3.90	2.97	0.32266454214005	1.51889361595545	0.161364322970176	0.521890396307658	1:2586490-2591469:+	FAM213B	16;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0043209,cellular_component myelin sheath;GO:0047017,molecular_function prostaglandin-F synthase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	PRXL2B, FAM213B; prostamide/prostaglandin F2alpha synthase [EC:1.11.1.20]; K15717	family with sequence similarity 213 member B [Source:HGNC Symbol%3BAcc:HGNC:28390]
ENSG00000109436	9.84	10.37	9.69	8.58	10.00	9.31	0.10930432199656	5.19786281113802	0.161489736956393	0.522159964792839	4:140620764-140756120:-	TBC1D9	9;GO:0005096,molecular_function GTPase activator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 9 [Source:HGNC Symbol%3BAcc:HGNC:21710]
ENSG00000197275	1.58	2.31	1.56	2.13	2.13	2.20	-0.259788913566177	2.49340415579262	0.16164134866683	0.522514078385772	8:94371959-94475109:-	RAD54B	16;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003724,molecular_function RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006312,biological_process mitotic recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007131,biological_process reciprocal meiotic recombination;GO:0015616,molecular_function DNA translocase activity;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding	RAD54B; DNA repair and recombination protein RAD54B [EC:3.6.4.-]; K10877	RAD54 homolog B (S. cerevisiae) [Source:HGNC Symbol%3BAcc:HGNC:17228]
ENSG00000266953	15.34	17.84	14.04	11.68	15.74	13.91	0.195645979992308	3.41821515932921	0.161797831847997	0.522883750775627	19:34396314-34409364:+	AC092073.1	3;GO:0004347,molecular_function glucose-6-phosphate isomerase activity;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process	NA	NA
ENSG00000106009	18.61	17.27	19.24	18.45	16.20	16.99	0.109049483662193	5.46040232677328	0.161875727510263	0.522999324722774	7:2537876-2555727:-	BRAT1	14;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006006,biological_process glucose metabolic process;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008283,biological_process cell proliferation;GO:0010212,biological_process response to ionizing radiation;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016477,biological_process cell migration;GO:0051646,biological_process mitochondrion localization	NA	BRCA1 associated ATM activator 1 [Source:HGNC Symbol%3BAcc:HGNC:21701]
ENSG00000163083	5.44	7.98	5.67	6.75	7.33	8.35	-0.240370304709429	3.09789676510695	0.161933252745455	0.523049041459623	2:120346142-120351808:+	INHBB	33;GO:0001541,biological_process ovarian follicle development;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005179,molecular_function hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006952,biological_process defense response;GO:0008083,molecular_function growth factor activity;GO:0009267,biological_process cellular response to starvation;GO:0009612,biological_process response to mechanical stimulus;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030154,biological_process cell differentiation;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032924,biological_process activin receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0044320,biological_process cellular response to leptin stimulus;GO:0044764,biological_process multi-organism cellular process;GO:0045444,biological_process fat cell differentiation;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046789,molecular_function host cell surface receptor binding;GO:0046881,biological_process positive regulation of follicle-stimulating hormone secretion;GO:0046882,biological_process negative regulation of follicle-stimulating hormone secretion;GO:0048178,biological_process negative regulation of hepatocyte growth factor biosynthetic process;GO:0048468,biological_process cell development;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048599,biological_process oocyte development;GO:0060279,biological_process positive regulation of ovulation;GO:0060395,biological_process SMAD protein signal transduction;GO:0071944,cellular_component cell periphery;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	INHBA; inhibin beta A chain; K04667	inhibin beta B subunit [Source:HGNC Symbol%3BAcc:HGNC:6067]
ENSG00000139192	16.15	14.97	15.94	14.99	14.04	14.62	0.123810121874739	4.41967889274607	0.162048173301404	0.523248651790672	12:6451689-6466517:+	TAPBPL	13;GO:0000139,cellular_component Golgi membrane;GO:0002376,biological_process immune system process;GO:0002590,biological_process negative regulation of antigen processing and presentation of peptide antigen via MHC class I;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031090,cellular_component organelle membrane;GO:0032403,molecular_function protein complex binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	TAP binding protein like [Source:HGNC Symbol%3BAcc:HGNC:30683]
ENSG00000149256	8.76	8.61	9.36	8.61	8.51	8.17	0.0929718677396485	6.18863031769	0.162079357619845	0.523248651790672	11:78652830-79440948:-	TENM4	26;GO:0000902,biological_process cell morphogenesis;GO:0001702,biological_process gastrulation with mouth forming second;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0031641,biological_process regulation of myelination;GO:0031643,biological_process positive regulation of myelination;GO:0032289,biological_process central nervous system myelin formation;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0046982,molecular_function protein heterodimerization activity;GO:0048666,biological_process neuron development;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0050839,molecular_function cell adhesion molecule binding;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060912,biological_process cardiac cell fate specification;GO:0097264,biological_process self proteolysis;GO:2000543,biological_process positive regulation of gastrulation	NA	teneurin transmembrane protein 4 [Source:HGNC Symbol%3BAcc:HGNC:29945]
ENSG00000240344	55.28	58.31	62.15	68.30	63.34	59.81	-0.111365223223554	5.31835757676303	0.162193638272019	0.523481443544091	2:200870906-200889303:-	PPIL3	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0006457,biological_process protein folding;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016853,molecular_function isomerase activity;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	peptidylprolyl isomerase like 3 [Source:HGNC Symbol%3BAcc:HGNC:9262]
ENSG00000120725	35.19	33.69	35.33	34.00	32.95	31.44	0.0969263572958544	5.59597378788522	0.162309971372805	0.523720736847056	5:138946719-139293557:-	SIL1	9;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006457,biological_process protein folding;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0051082,molecular_function unfolded protein binding	SIL1, SLS1; nucleotide exchange factor SIL1; K14001	SIL1 nucleotide exchange factor [Source:HGNC Symbol%3BAcc:HGNC:24624]
ENSG00000186432	51.96	45.55	52.93	52.98	54.49	55.07	-0.0965302366249028	6.3545634819652	0.162430948112885	0.523974885375583	3:160494994-160565588:-	KPNA4	17;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0019054,biological_process modulation by virus of host process;GO:0042542,biological_process response to hydrogen peroxide;GO:0043657,cellular_component host cell;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus	NA	karyopherin subunit alpha 4 [Source:HGNC Symbol%3BAcc:HGNC:6397]
ENSG00000011523	8.30	7.58	9.74	9.08	9.88	9.60	-0.137684444834798	4.4727082515312	0.162821960260726	0.525064738563773	2:65056365-65087004:+	CEP68	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007098,biological_process centrosome cycle;GO:0010457,biological_process centriole-centriole cohesion;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0033365,biological_process protein localization to organelle	NA	centrosomal protein 68 [Source:HGNC Symbol%3BAcc:HGNC:29076]
ENSG00000117724	35.85	39.69	34.56	37.14	45.41	37.88	-0.117947245719326	8.49388010514132	0.162876074274977	0.525064738563773	1:214603194-214664588:+	CENPF	49;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000785,cellular_component chromatin;GO:0000922,cellular_component spindle pole;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0001822,biological_process kidney development;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005930,cellular_component axoneme;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015031,biological_process protein transport;GO:0016202,biological_process regulation of striated muscle tissue development;GO:0016363,cellular_component nuclear matrix;GO:0021591,biological_process ventricular system development;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0036064,cellular_component ciliary basal body;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0045120,cellular_component pronucleus;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0051310,biological_process metaphase plate congression;GO:0051382,biological_process kinetochore assembly;GO:0051726,biological_process regulation of cell cycle;GO:0070840,molecular_function dynein complex binding;GO:0071897,biological_process DNA biosynthetic process;GO:0097539,cellular_component ciliary transition fiber	NA	centromere protein F [Source:HGNC Symbol%3BAcc:HGNC:1857]
ENSG00000099246	60.82	66.05	60.15	56.28	59.16	60.90	0.0931668625090808	5.95606087441241	0.162895698719817	0.525064738563773	10:27504173-27542237:+	RAB18	25;GO:0000166,molecular_function nucleotide binding;GO:0001654,biological_process eye development;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030667,cellular_component secretory granule membrane;GO:0034389,biological_process lipid particle organization;GO:0043312,biological_process neutrophil degranulation;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0071786,biological_process endoplasmic reticulum tubular network organization;GO:1902593,biological_process single-organism nuclear import	NA	RAB18%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:14244]
ENSG00000186007	2.60	2.11	3.12	5.24	2.23	3.37	-0.439704635015094	0.896016214652609	0.16306010092555	0.525458212042797	1:205381377-205457091:-	LEMD1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	LEM domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18725]
ENSG00000140057	4.23	4.04	4.67	5.05	5.18	4.49	-0.166596731108549	3.41221044905165	0.163190542602663	0.52574207249594	14:96392110-96489427:+	AK7	19;GO:0000166,molecular_function nucleotide binding;GO:0004017,molecular_function adenylate kinase activity;GO:0004127,molecular_function cytidylate kinase activity;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0009142,biological_process nucleoside triphosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0030030,biological_process cell projection organization;GO:0046939,biological_process nucleotide phosphorylation	adk, AK; adenylate kinase [EC:2.7.4.3]; K00939	adenylate kinase 7 [Source:HGNC Symbol%3BAcc:HGNC:20091]
ENSG00000173548	26.29	21.81	25.73	26.22	19.29	21.72	0.150098508781392	5.34787049230597	0.16324657751422	0.525786135621177	15:75647905-75662301:+	SNX33	28;GO:0000278,biological_process mitotic cell cycle;GO:0000281,biological_process mitotic cytokinesis;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007032,biological_process endosome organization;GO:0007049,biological_process cell cycle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0017038,biological_process protein import;GO:0019898,cellular_component extrinsic component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036089,biological_process cleavage furrow formation;GO:0042802,molecular_function identical protein binding;GO:0044351,biological_process macropinocytosis;GO:0045806,biological_process negative regulation of endocytosis;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0051301,biological_process cell division;GO:0097320,biological_process membrane tubulation;GO:2000009,biological_process negative regulation of protein localization to cell surface;GO:2000010,biological_process positive regulation of protein localization to cell surface	NA	sorting nexin 33 [Source:HGNC Symbol%3BAcc:HGNC:28468]
ENSG00000116857	102.49	94.97	99.16	104.70	103.59	110.44	-0.0902206864238438	6.05309372322003	0.163395282265478	0.526007745431164	1:201134771-201171574:-	TMEM9	10;GO:0003674,molecular_function molecular_function;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane	NA	transmembrane protein 9 [Source:HGNC Symbol%3BAcc:HGNC:18823]
ENSG00000184828	1.90	2.42	2.14	2.82	2.41	2.46	-0.253287785011157	2.17761164114342	0.16340013424495	0.526007745431164	18:48026672-48410752:-	ZBTB7C	9;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0008285,biological_process negative regulation of cell proliferation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1903025,biological_process regulation of RNA polymerase II regulatory region sequence-specific DNA binding	NA	zinc finger and BTB domain containing 7C [Source:HGNC Symbol%3BAcc:HGNC:31700]
ENSG00000140104	14.63	13.80	14.91	15.64	15.36	16.99	-0.132870045207421	4.0840916621738	0.163468715185844	0.526092082344279	14:104985774-105010482:+	C14orf79	NA	NA	chromosome 14 open reading frame 79 [Source:HGNC Symbol%3BAcc:HGNC:20126]
ENSG00000133392	1.46	1.46	1.47	1.68	1.78	1.52	-0.171063625307308	3.24396866874475	0.163590021645428	0.526346018321592	16:15703171-15857033:-	MYH11	19;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005859,cellular_component muscle myosin complex;GO:0006936,biological_process muscle contraction;GO:0006939,biological_process smooth muscle contraction;GO:0008307,molecular_function structural constituent of muscle;GO:0016459,cellular_component myosin complex;GO:0030241,biological_process skeletal muscle myosin thick filament assembly;GO:0032982,cellular_component myosin filament;GO:0042470,cellular_component melanosome;GO:0048251,biological_process elastic fiber assembly;GO:0048739,biological_process cardiac muscle fiber development;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	MYH; myosin heavy chain; K10352	myosin heavy chain 11 [Source:HGNC Symbol%3BAcc:HGNC:7569]
ENSG00000145375	2.32	3.03	2.91	2.96	3.03	3.60	-0.214775640105092	3.02159376699621	0.163721988054761	0.526634111874514	4:122923073-123319450:+	SPATA5	8;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007420,biological_process brain development;GO:0030154,biological_process cell differentiation	AFG2, DRG1, SPATA5; AAA family ATPase; K14575	spermatogenesis associated 5 [Source:HGNC Symbol%3BAcc:HGNC:18119]
ENSG00000107581	96.06	94.44	91.18	85.04	92.78	89.92	0.0849140685935031	8.57005149452756	0.163832932923167	0.526789623034631	10:119033669-119080823:-	EIF3A	23;GO:0001732,biological_process formation of cytoplasmic translation initiation complex;GO:0002188,biological_process translation reinitiation;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0005874,cellular_component microtubule;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0016020,cellular_component membrane;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0043614,cellular_component multi-eIF complex;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071540,cellular_component eukaryotic translation initiation factor 3 complex, eIF3e;GO:0071541,cellular_component eukaryotic translation initiation factor 3 complex, eIF3m;GO:0075522,biological_process IRES-dependent viral translational initiation;GO:0075525,biological_process viral translational termination-reinitiation	EIF3A; translation initiation factor 3 subunit A; K03254	eukaryotic translation initiation factor 3 subunit A [Source:HGNC Symbol%3BAcc:HGNC:3271]
ENSG00000110195	101.59	100.15	119.71	114.49	117.85	116.47	-0.104356711531363	6.43294622436043	0.163869931567186	0.526789623034631	11:72189557-72196323:+	FOLR1	45;GO:0000139,cellular_component Golgi membrane;GO:0001947,biological_process heart looping;GO:0003147,biological_process neural crest cell migration involved in heart formation;GO:0003253,biological_process cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:0004872,molecular_function receptor activity;GO:0005542,molecular_function folic acid binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005768,cellular_component endosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008144,molecular_function drug binding;GO:0008517,molecular_function folic acid transporter activity;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015884,biological_process folic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030133,cellular_component transport vesicle;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031103,biological_process axon regeneration;GO:0031225,cellular_component anchored component of membrane;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031526,cellular_component brush border membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0046655,biological_process folic acid metabolic process;GO:0046658,cellular_component anchored component of plasma membrane;GO:0048208,biological_process COPII vesicle coating;GO:0048678,biological_process response to axon injury;GO:0051870,molecular_function methotrexate binding;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0061626,biological_process pharyngeal arch artery morphogenesis;GO:0061713,biological_process anterior neural tube closure;GO:0061714,molecular_function folic acid receptor activity;GO:0070062,cellular_component extracellular exosome;GO:0071231,biological_process cellular response to folic acid	FOLR; folate receptor; K13649	folate receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:3791]
ENSG00000131100	171.26	182.22	169.70	164.78	172.02	157.94	0.0914373005964373	7.0350461371304	0.163928034543066	0.526789623034631	22:17592135-17628818:-	ATP6V1E1	24;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005902,cellular_component microvillus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008553,molecular_function hydrogen-exporting ATPase activity, phosphorylative mechanism;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016241,biological_process regulation of macroautophagy;GO:0016324,cellular_component apical plasma membrane;GO:0016469,cellular_component proton-transporting two-sector ATPase complex;GO:0016787,molecular_function hydrolase activity;GO:0033178,cellular_component proton-transporting two-sector ATPase complex, catalytic domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E; K02150	ATPase H+ transporting V1 subunit E1 [Source:HGNC Symbol%3BAcc:HGNC:857]
ENSG00000184575	128.28	100.43	126.21	134.10	117.18	140.03	-0.128382422221384	8.48960700773189	0.163950836377204	0.526789623034631	12:64404349-64451127:+	XPOT	13;GO:0000049,molecular_function tRNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008536,molecular_function Ran GTPase binding;GO:0016363,cellular_component nuclear matrix;GO:0071528,biological_process tRNA re-export from nucleus	XPOT; exportin-T; K14288	exportin for tRNA [Source:HGNC Symbol%3BAcc:HGNC:12826]
ENSG00000057704	6.42	4.74	5.30	6.49	5.83	6.78	-0.191450613818048	3.12029551963008	0.163995449164304	0.526789623034631	12:94567123-94650562:-	TMCC3	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane and coiled-coil domain family 3 [Source:HGNC Symbol%3BAcc:HGNC:29199]
ENSG00000166188	4.05	2.85	3.50	3.86	4.21	4.15	-0.204611927069458	2.76321723570283	0.164024965200101	0.526789623034631	16:57994667-58000453:-	ZNF319	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 319 [Source:HGNC Symbol%3BAcc:HGNC:13644]
ENSG00000124523	31.99	29.02	33.19	33.61	33.19	35.95	-0.109106315887715	5.01539687730062	0.16413029857165	0.526991566520923	6:13574528-13615158:+	SIRT5	29;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006342,biological_process chromatin silencing;GO:0006471,biological_process protein ADP-ribosylation;GO:0006476,biological_process protein deacetylation;GO:0007005,biological_process mitochondrion organization;GO:0008270,molecular_function zinc ion binding;GO:0010566,biological_process regulation of ketone biosynthetic process;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0016787,molecular_function hydrolase activity;GO:0031667,biological_process response to nutrient levels;GO:0034979,molecular_function NAD-dependent protein deacetylase activity;GO:0036046,biological_process protein demalonylation;GO:0036047,biological_process peptidyl-lysine demalonylation;GO:0036048,biological_process protein desuccinylation;GO:0036049,biological_process peptidyl-lysine desuccinylation;GO:0036054,molecular_function protein-malonyllysine demalonylase activity;GO:0036055,molecular_function protein-succinyllysine desuccinylase activity;GO:0046872,molecular_function metal ion binding;GO:0061697,molecular_function protein-glutaryllysine deglutarylase activity;GO:0061698,biological_process protein deglutarylation;GO:0061699,biological_process peptidyl-lysine deglutarylation;GO:0070403,molecular_function NAD+ binding;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	SIRT5, SIR2L5; NAD+-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]; K11415	sirtuin 5 [Source:HGNC Symbol%3BAcc:HGNC:14933]
ENSG00000172732	21.90	21.93	22.70	21.81	20.52	20.34	0.0986709185223441	5.34043711985913	0.164197719055679	0.527071705880048	11:65857125-65867653:+	MUS81	25;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000727,biological_process double-strand break repair via break-induced replication;GO:0000737,biological_process DNA catabolic process, endonucleolytic;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0031297,biological_process replication fork processing;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0036297,biological_process interstrand cross-link repair;GO:0046872,molecular_function metal ion binding;GO:0048257,molecular_function 3'-flap endonuclease activity;GO:0048476,cellular_component Holliday junction resolvase complex;GO:0072429,biological_process response to intra-S DNA damage checkpoint signaling;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]; K08991	MUS81 structure-specific endonuclease subunit [Source:HGNC Symbol%3BAcc:HGNC:29814]
ENSG00000166478	7.61	7.28	7.97	6.76	7.58	6.55	0.146262331352769	3.92419489810578	0.164321728006947	0.52733340479582	11:9460318-9528524:+	ZNF143	16;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 143 [Source:HGNC Symbol%3BAcc:HGNC:12928]
ENSG00000101290	26.08	25.13	25.75	30.23	27.04	26.44	-0.107775722885412	5.16781026937064	0.164486851757903	0.527726877971271	20:5126785-5197887:+	CDS2	14;GO:0004605,molecular_function phosphatidate cytidylyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006655,biological_process phosphatidylglycerol biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0016779,molecular_function nucleotidyltransferase activity	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]; K00981	CDP-diacylglycerol synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:1801]
ENSG00000164318	5.66	5.26	4.88	6.05	5.11	6.61	-0.157988040247936	4.13568264141334	0.164841088921854	0.528726727851931	5:38258408-38465021:+	EGFLAM	12;GO:0005509,molecular_function calcium ion binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005614,cellular_component interstitial matrix;GO:0009986,cellular_component cell surface;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0019800,biological_process peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0045202,cellular_component synapse	NA	EGF like%2C fibronectin type III and laminin G domains [Source:HGNC Symbol%3BAcc:HGNC:26810]
ENSG00000196123	6.10	6.22	6.41	4.24	5.96	6.12	0.208349773987181	3.07049757022815	0.165199484859323	0.529739396941041	16:67175601-67184040:-	KIAA0895L	NA	NA	KIAA0895 like [Source:HGNC Symbol%3BAcc:HGNC:34408]
ENSG00000111300	7.75	7.24	7.34	9.13	7.33	8.27	-0.133279523048695	4.55400079532416	0.165317363205278	0.529980482816922	12:112026688-112109022:-	NAA25	6;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0017196,biological_process N-terminal peptidyl-methionine acetylation;GO:0031416,cellular_component NatB complex	NA	N(alpha)-acetyltransferase 25%2C NatB auxiliary subunit [Source:HGNC Symbol%3BAcc:HGNC:25783]
ENSG00000143633	13.64	14.77	14.47	16.42	14.74	16.70	-0.151619203150645	3.75212070856584	0.165394581952409	0.530091129815454	1:231223762-231241187:-	C1orf131	2;GO:0003723,molecular_function RNA binding;GO:0005694,cellular_component chromosome	NA	chromosome 1 open reading frame 131 [Source:HGNC Symbol%3BAcc:HGNC:25332]
ENSG00000166716	11.39	11.89	12.01	11.13	11.11	11.06	0.0940147001866246	5.44643814947641	0.165946447835991	0.531677396476953	15:84748634-84806432:+	ZNF592	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 592 [Source:HGNC Symbol%3BAcc:HGNC:28986]
ENSG00000198841	9.44	10.44	7.21	7.68	8.07	7.81	0.202302801264082	3.18003689586223	0.165975180161781	0.531677396476953	1:52032102-52033816:-	KTI12	3;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding	NA	KTI12 chromatin associated homolog [Source:HGNC Symbol%3BAcc:HGNC:25160]
ENSG00000198060	41.92	37.47	37.33	44.62	39.10	43.76	-0.113238118156072	5.09458853415972	0.166031611381297	0.53172094738804	10:92291162-92353964:+	MARCH5	19;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0051020,molecular_function GTPase binding;GO:0051865,biological_process protein autoubiquitination;GO:0070585,biological_process protein localization to mitochondrion;GO:0090140,biological_process regulation of mitochondrial fission;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090344,biological_process negative regulation of cell aging	NA	membrane associated ring-CH-type finger 5 [Source:HGNC Symbol%3BAcc:HGNC:26025]
ENSG00000005884	743.61	684.70	768.37	835.41	723.40	812.72	-0.0987047410853718	11.3640688089711	0.166086821140674	0.531760565081037	17:50055967-50090481:+	ITGA3	59;GO:0001764,biological_process neuron migration;GO:0001968,molecular_function fibronectin binding;GO:0002020,molecular_function protease binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007507,biological_process heart development;GO:0007613,biological_process memory;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030198,biological_process extracellular matrix organization;GO:0030324,biological_process lung development;GO:0030426,cellular_component growth cone;GO:0030510,biological_process regulation of BMP signaling pathway;GO:0031345,biological_process negative regulation of cell projection organization;GO:0031527,cellular_component filopodium membrane;GO:0034667,cellular_component integrin alpha3-beta1 complex;GO:0034698,biological_process response to gonadotropin;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0035640,biological_process exploration behavior;GO:0042493,biological_process response to drug;GO:0042995,cellular_component cell projection;GO:0043235,cellular_component receptor complex;GO:0043236,molecular_function laminin binding;GO:0043588,biological_process skin development;GO:0044708,biological_process single-organism behavior;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048333,biological_process mesodermal cell differentiation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050900,biological_process leukocyte migration;GO:0060076,cellular_component excitatory synapse;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0070062,cellular_component extracellular exosome;GO:0071438,cellular_component invadopodium membrane;GO:0071944,cellular_component cell periphery;GO:0072006,biological_process nephron development;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0097060,cellular_component synaptic membrane;GO:0097062,biological_process dendritic spine maintenance;GO:0097205,biological_process renal filtration	ITGA3, CD49c; integrin alpha 3; K06482	integrin subunit alpha 3 [Source:HGNC Symbol%3BAcc:HGNC:6139]
ENSG00000155760	10.34	9.32	8.93	10.00	10.75	10.94	-0.134420216997361	4.12893106403244	0.166227034094368	0.531833718003032	2:202034586-202038445:+	FZD7	41;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0010008,cellular_component endosome membrane;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0014834,biological_process skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0019827,biological_process stem cell population maintenance;GO:0030165,molecular_function PDZ domain binding;GO:0030182,biological_process neuron differentiation;GO:0033077,biological_process T cell differentiation in thymus;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035412,biological_process regulation of catenin import into nucleus;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0038031,biological_process non-canonical Wnt signaling pathway via JNK cascade;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042666,biological_process negative regulation of ectodermal cell fate specification;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048103,biological_process somatic stem cell division;GO:0055038,cellular_component recycling endosome membrane;GO:0060054,biological_process positive regulation of epithelial cell proliferation involved in wound healing;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060231,biological_process mesenchymal to epithelial transition;GO:0071300,biological_process cellular response to retinoic acid;GO:2000726,biological_process negative regulation of cardiac muscle cell differentiation	FZD1_7, fz; frizzled 1/7; K02432	frizzled class receptor 7 [Source:HGNC Symbol%3BAcc:HGNC:4045]
ENSG00000162836	20.97	20.67	23.30	22.85	23.43	24.53	-0.11124215708496	4.91827953851531	0.166252115006161	0.531833718003032	1:147629651-147670496:-	ACP6	12;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003993,molecular_function acid phosphatase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0052642,molecular_function lysophosphatidic acid phosphatase activity;GO:2001311,biological_process lysobisphosphatidic acid metabolic process	NA	acid phosphatase 6%2C lysophosphatidic [Source:HGNC Symbol%3BAcc:HGNC:29609]
ENSG00000170835	0.84	0.38	0.39	0.40	0.50	0.19	0.617808529113531	0.236075178790184	0.166258578074998	0.531833718003032	9:133061977-133071861:+	CEL	4;GO:0006629,biological_process lipid metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0046514,biological_process ceramide catabolic process	CEL; bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13]; K12298	carboxyl ester lipase [Source:HGNC Symbol%3BAcc:HGNC:1848]
ENSG00000196954	69.48	62.40	67.59	64.70	60.32	63.66	0.0942678759050433	6.32561327285426	0.166281048865687	0.531833718003032	11:104942865-104969436:-	CASP4	31;GO:0002376,biological_process immune system process;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045087,biological_process innate immune response;GO:0050700,molecular_function CARD domain binding;GO:0050727,biological_process regulation of inflammatory response;GO:0061702,cellular_component inflammasome complex;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0072557,cellular_component IPAF inflammasome complex;GO:0072559,cellular_component NLRP3 inflammasome complex;GO:0097153,molecular_function cysteine-type endopeptidase activity involved in apoptotic process;GO:0097169,cellular_component AIM2 inflammasome complex;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1903265,biological_process positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1904646,biological_process cellular response to beta-amyloid	CASP4, CASP11; caspase 4 [EC:3.4.22.57 3.4.22.64]; K04394	caspase 4 [Source:HGNC Symbol%3BAcc:HGNC:1505]
ENSG00000175895	23.54	21.75	24.53	25.06	29.44	23.63	-0.14423490682114	4.21844240020451	0.166354325572785	0.531931026103808	8:95133803-95156684:+	PLEKHF2	9;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030133,cellular_component transport vesicle;GO:0031901,cellular_component early endosome membrane;GO:0046872,molecular_function metal ion binding	NA	pleckstrin homology and FYVE domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20757]
ENSG00000176783	23.68	23.12	23.94	25.35	25.62	24.86	-0.0870948942034566	5.88475435940005	0.166479024319977	0.532060856045604	5:179550557-179610026:+	RUFY1	16;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030100,biological_process regulation of endocytosis;GO:0031901,cellular_component early endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	RUFY1, RABIP4; RUN and FYVE domain-containing protein 1; K12482	RUN and FYVE domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19760]
ENSG00000171522	2.46	1.57	2.31	1.74	2.07	1.30	0.350415037133947	1.56695599438365	0.166480654546131	0.532060856045604	5:40679497-40693735:+	PTGER4	29;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004955,molecular_function prostaglandin receptor activity;GO:0004957,molecular_function prostaglandin E receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007254,biological_process JNK cascade;GO:0009612,biological_process response to mechanical stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030278,biological_process regulation of ossification;GO:0032496,biological_process response to lipopolysaccharide;GO:0033624,biological_process negative regulation of integrin activation;GO:0042093,biological_process T-helper cell differentiation;GO:0050710,biological_process negative regulation of cytokine secretion;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051492,biological_process regulation of stress fiber assembly;GO:0060348,biological_process bone development;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:2000420,biological_process negative regulation of eosinophil extravasation	PTGER4; prostaglandin E receptor 4; K04261	prostaglandin E receptor 4 [Source:HGNC Symbol%3BAcc:HGNC:9596]
ENSG00000111707	25.19	22.43	24.53	22.75	22.20	22.15	0.1224853424685	4.52525441849855	0.166546940642821	0.532135694774605	12:118376379-118418031:+	SUDS3	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016579,biological_process protein deubiquitination;GO:0016580,cellular_component Sin3 complex;GO:0016604,cellular_component nuclear body;GO:0019899,molecular_function enzyme binding;GO:0021762,biological_process substantia nigra development;GO:0042826,molecular_function histone deacetylase binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070822,cellular_component Sin3-type complex	NA	SDS3 homolog%2C SIN3A corepressor complex component [Source:HGNC Symbol%3BAcc:HGNC:29545]
ENSG00000168172	3.70	3.96	3.22	3.75	4.15	4.56	-0.194470317412958	3.10645569433178	0.166688217086135	0.532330273298234	8:42896931-43030539:+	HOOK3	29;GO:0000242,cellular_component pericentriolar material;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0008017,molecular_function microtubule binding;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0022027,biological_process interkinetic nuclear migration;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0030897,cellular_component HOPS complex;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0034451,cellular_component centriolar satellite;GO:0034454,biological_process microtubule anchoring at centrosome;GO:0042802,molecular_function identical protein binding;GO:0045022,biological_process early endosome to late endosome transport;GO:0050768,biological_process negative regulation of neurogenesis;GO:0051645,biological_process Golgi localization;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0070695,cellular_component FHF complex;GO:0071539,biological_process protein localization to centrosome;GO:0097150,biological_process neuronal stem cell population maintenance	NA	hook microtubule tethering protein 3 [Source:HGNC Symbol%3BAcc:HGNC:23576]
ENSG00000110108	54.35	52.70	55.33	48.99	51.60	52.47	0.0982994998683817	5.26702941457288	0.166735218627043	0.532330273298234	11:60913873-60923443:+	TMEM109	17;GO:0003674,molecular_function molecular_function;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:0071480,biological_process cellular response to gamma radiation	NA	transmembrane protein 109 [Source:HGNC Symbol%3BAcc:HGNC:28771]
ENSG00000136152	6.74	6.11	6.21	5.59	5.69	6.20	0.138413299910021	3.99924180400451	0.166740359968223	0.532330273298234	13:45464897-45536630:+	COG3	19;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006486,biological_process protein glycosylation;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032580,cellular_component Golgi cisterna membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0033365,biological_process protein localization to organelle;GO:0050821,biological_process protein stabilization	NA	component of oligomeric golgi complex 3 [Source:HGNC Symbol%3BAcc:HGNC:18619]
ENSG00000147118	7.38	7.02	7.28	6.08	7.14	6.51	0.150114755306253	3.75429078310103	0.166826898713201	0.532330273298234	X:47974850-48003978:-	ZNF182	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 182 [Source:HGNC Symbol%3BAcc:HGNC:13001]
ENSG00000214517	51.14	52.40	48.64	48.11	48.41	47.58	0.0888089660618057	5.89246748015518	0.166899964658169	0.532330273298234	11:74171098-74254703:+	PPME1	15;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005654,cellular_component nucleoplasm;GO:0006482,biological_process protein demethylation;GO:0016787,molecular_function hydrolase activity;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045296,molecular_function cadherin binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0051722,molecular_function protein C-terminal methylesterase activity;GO:0051723,molecular_function protein methylesterase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity	NA	protein phosphatase methylesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:30178]
ENSG00000073060	27.16	31.81	33.34	28.63	27.86	29.61	0.109996908834526	5.83405660373075	0.16690671981638	0.532330273298234	12:124776855-124882668:-	SCARB1	60;GO:0001530,molecular_function lipopolysaccharide binding;GO:0001540,molecular_function beta-amyloid binding;GO:0001618,molecular_function virus receptor activity;GO:0001786,molecular_function phosphatidylserine binding;GO:0001875,molecular_function lipopolysaccharide receptor activity;GO:0001935,biological_process endothelial cell proliferation;GO:0005044,molecular_function scavenger receptor activity;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0006702,biological_process androgen biosynthetic process;GO:0006707,biological_process cholesterol catabolic process;GO:0006869,biological_process lipid transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006910,biological_process phagocytosis, recognition;GO:0008035,molecular_function high-density lipoprotein particle binding;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0010886,biological_process positive regulation of cholesterol storage;GO:0010899,biological_process regulation of phosphatidylcholine catabolic process;GO:0015914,biological_process phospholipid transport;GO:0015920,biological_process lipopolysaccharide transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030301,biological_process cholesterol transport;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031528,cellular_component microvillus membrane;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032497,biological_process detection of lipopolysaccharide;GO:0033344,biological_process cholesterol efflux;GO:0034185,molecular_function apolipoprotein binding;GO:0034186,molecular_function apolipoprotein A-I binding;GO:0034375,biological_process high-density lipoprotein particle remodeling;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0034384,biological_process high-density lipoprotein particle clearance;GO:0035461,biological_process vitamin transmembrane transport;GO:0042060,biological_process wound healing;GO:0042632,biological_process cholesterol homeostasis;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043534,biological_process blood vessel endothelial cell migration;GO:0043654,biological_process recognition of apoptotic cell;GO:0043691,biological_process reverse cholesterol transport;GO:0044406,biological_process adhesion of symbiont to host;GO:0046718,biological_process viral entry into host cell;GO:0050764,biological_process regulation of phagocytosis;GO:0050892,biological_process intestinal absorption;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0070062,cellular_component extracellular exosome;GO:0070328,biological_process triglyceride homeostasis;GO:0070506,molecular_function high-density lipoprotein particle receptor activity;GO:0070508,biological_process cholesterol import	SCARB1; scavenger receptor class B, member 1; K13885	scavenger receptor class B member 1 [Source:HGNC Symbol%3BAcc:HGNC:1664]
ENSG00000132388	76.58	74.39	76.78	77.37	81.79	87.00	-0.0998693577173295	5.33970047788166	0.166908033809452	0.532330273298234	17:4269258-4366628:-	UBE2G1	15;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0044257,biological_process cellular protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070062,cellular_component extracellular exosome;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination	UBE2G1, UBC7; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]; K10575	ubiquitin conjugating enzyme E2 G1 [Source:HGNC Symbol%3BAcc:HGNC:12482]
ENSG00000120913	1.49	1.03	1.44	1.27	0.70	1.16	0.36558425229335	1.30365039639166	0.167023136068225	0.532560541488537	8:22578278-22598025:+	PDLIM2	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	PDZ and LIM domain 2 [Source:HGNC Symbol%3BAcc:HGNC:13992]
ENSG00000108423	6.78	4.94	7.01	4.99	5.89	5.60	0.211575613539286	3.14200585283097	0.167100316703687	0.53266980771517	17:59859481-59892945:-	TUBD1	18;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation	NA	tubulin delta 1 [Source:HGNC Symbol%3BAcc:HGNC:16811]
ENSG00000204385	1.36	1.48	1.42	1.02	1.32	1.12	0.306139476895772	1.52462389379741	0.167276902474586	0.533095812687301	6:31863191-31879046:-	SLC44A4	16;GO:0005886,cellular_component plasma membrane;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0008292,biological_process acetylcholine biosynthetic process;GO:0015220,molecular_function choline transmembrane transporter activity;GO:0015871,biological_process choline transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030307,biological_process positive regulation of cell growth;GO:0030974,biological_process thiamine pyrophosphate transport;GO:0032475,biological_process otolith formation;GO:0035675,biological_process neuromast hair cell development;GO:0055085,biological_process transmembrane transport;GO:0061526,biological_process acetylcholine secretion;GO:0070062,cellular_component extracellular exosome;GO:0090422,molecular_function thiamine pyrophosphate transporter activity	SLC44A2_4_5; solute carrier family 44 (choline transporter-like protein), member 2/4/5; K15377	solute carrier family 44 member 4 [Source:HGNC Symbol%3BAcc:HGNC:13941]
ENSG00000164164	7.37	8.06	6.45	7.77	8.12	8.16	-0.131490312618346	4.6853123178407	0.167408288688875	0.533377589192764	4:145110837-145180161:-	OTUD4	10;GO:0003723,molecular_function RNA binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0071108,biological_process protein K48-linked deubiquitination	NA	OTU deubiquitinase 4 [Source:HGNC Symbol%3BAcc:HGNC:24949]
ENSG00000170364	3.07	3.78	3.36	2.58	3.10	3.21	0.19975306692353	2.90881652459124	0.167562959355251	0.533567971933425	3:4303303-4317567:+	SETMAR	45;GO:0000014,molecular_function single-stranded DNA endodeoxyribonuclease activity;GO:0000729,biological_process DNA double-strand break processing;GO:0000737,biological_process DNA catabolic process, endonucleolytic;GO:0000793,cellular_component condensed chromosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0010452,biological_process histone H3-K36 methylation;GO:0015074,biological_process DNA integration;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0031297,biological_process replication fork processing;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0035861,cellular_component site of double-strand break;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0042803,molecular_function protein homodimerization activity;GO:0044547,molecular_function DNA topoisomerase binding;GO:0044774,biological_process mitotic DNA integrity checkpoint;GO:0046872,molecular_function metal ion binding;GO:0046975,molecular_function histone methyltransferase activity (H3-K36 specific);GO:0051568,biological_process histone H3-K4 methylation;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0097676,biological_process histone H3-K36 dimethylation;GO:2000373,biological_process positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:2001034,biological_process positive regulation of double-strand break repair via nonhomologous end joining;GO:2001251,biological_process negative regulation of chromosome organization	SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357]; K11433	SET domain and mariner transposase fusion gene [Source:HGNC Symbol%3BAcc:HGNC:10762]
ENSG00000082641	129.52	102.65	131.35	146.76	112.43	147.29	-0.148893125157533	8.34794655302648	0.16756377825472	0.533567971933425	17:48048328-48061487:+	NFE2L1	29;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006783,biological_process heme biosynthetic process;GO:0006954,biological_process inflammatory response;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030218,biological_process erythrocyte differentiation;GO:0032403,molecular_function protein complex binding;GO:0034599,biological_process cellular response to oxidative stress;GO:0043234,cellular_component protein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	nuclear factor%2C erythroid 2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:7781]
ENSG00000185803	29.26	32.16	27.63	25.93	30.58	25.93	0.120192606848721	5.25931931088522	0.167596996903925	0.533567971933425	8:144354134-144361272:+	SLC52A2	11;GO:0001618,molecular_function virus receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006771,biological_process riboflavin metabolic process;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032217,molecular_function riboflavin transporter activity;GO:0032218,biological_process riboflavin transport;GO:0046718,biological_process viral entry into host cell	NA	solute carrier family 52 member 2 [Source:HGNC Symbol%3BAcc:HGNC:30224]
ENSG00000135127	0.58	0.63	0.15	0.04	0.43	0.36	0.698479081331332	-0.235940600870565	0.167815936097159	0.534086772456848	12:119989868-120094494:+	BICDL1	10;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0007399,biological_process nervous system development;GO:0017137,molecular_function Rab GTPase binding;GO:0031175,biological_process neuron projection development;GO:0034452,molecular_function dynactin binding;GO:0055107,biological_process Golgi to secretory granule transport	NA	BICD family like cargo adaptor 1 [Source:HGNC Symbol%3BAcc:HGNC:28095]
ENSG00000107829	34.00	30.31	35.01	32.17	28.59	32.09	0.112917701079572	5.31514893552916	0.167851806778484	0.534086772456848	10:101610663-101695295:-	FBXW4	17;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0003674,molecular_function molecular_function;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007275,biological_process multicellular organism development;GO:0016055,biological_process Wnt signaling pathway;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030326,biological_process embryonic limb morphogenesis;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043687,biological_process post-translational protein modification;GO:0051216,biological_process cartilage development;GO:0060173,biological_process limb development	NA	F-box and WD repeat domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:10847]
ENSG00000020577	6.62	8.41	7.45	9.50	7.41	8.39	-0.167264638031611	4.18097997428932	0.16794841063753	0.534086772456848	14:54567096-54793315:+	SAMD4A	19;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0017148,biological_process negative regulation of translation;GO:0030054,cellular_component cell junction;GO:0030371,molecular_function translation repressor activity;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043488,biological_process regulation of mRNA stability;GO:0045202,cellular_component synapse;GO:0045727,biological_process positive regulation of translation	NA	sterile alpha motif domain containing 4A [Source:HGNC Symbol%3BAcc:HGNC:23023]
ENSG00000173258	0.67	0.40	0.70	0.47	0.35	0.50	0.475932300308629	0.490881611280087	0.167966616143885	0.534086772456848	9:111525158-111577844:+	ZNF483	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 483 [Source:HGNC Symbol%3BAcc:HGNC:23384]
ENSG00000149571	1.36	1.14	0.97	1.20	0.81	0.75	0.347143403701959	1.4187768348856	0.168100015358504	0.534086772456848	11:126423358-127003460:-	KIRREL3	17;GO:0001764,biological_process neuron migration;GO:0002121,biological_process inter-male aggressive behavior;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416,biological_process synapse assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021740,biological_process principal sensory nucleus of trigeminal nerve development;GO:0021766,biological_process hippocampus development;GO:0030097,biological_process hemopoiesis;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0043198,cellular_component dendritic shaft;GO:0048812,biological_process neuron projection morphogenesis;GO:0072102,biological_process glomerulus morphogenesis	NA	kirre like nephrin family adhesion molecule 3 [Source:HGNC Symbol%3BAcc:HGNC:23204]
ENSG00000214253	75.61	82.07	73.60	73.66	73.83	70.11	0.0964672657172169	5.67201075253122	0.168116460098398	0.534086772456848	7:101239457-101252316:-	FIS1	41;GO:0000266,biological_process mitochondrial fission;GO:0000422,biological_process mitophagy;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006915,biological_process apoptotic process;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008053,biological_process mitochondrial fusion;GO:0010821,biological_process regulation of mitochondrion organization;GO:0014850,biological_process response to muscle activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016559,biological_process peroxisome fission;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0032403,molecular_function protein complex binding;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0051260,biological_process protein homooligomerization;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0070584,biological_process mitochondrion morphogenesis;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071396,biological_process cellular response to lipid;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0097237,biological_process cellular response to toxic substance;GO:1901653,biological_process cellular response to peptide;GO:1904579,biological_process cellular response to thapsigargin;GO:1905395,biological_process response to flavonoid;GO:1990910,biological_process response to hypobaric hypoxia;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	NA	fission%2C mitochondrial 1 [Source:HGNC Symbol%3BAcc:HGNC:21689]
ENSG00000130669	26.54	29.07	26.41	29.04	29.70	29.40	-0.0961807606973437	5.74595850673482	0.168149167744245	0.534086772456848	19:39125769-39182816:+	PAK4	34;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006928,biological_process movement of cell or subcellular component;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008283,biological_process cell proliferation;GO:0016049,biological_process cell growth;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030036,biological_process actin cytoskeleton organization;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0048365,molecular_function Rac GTPase binding;GO:0060996,biological_process dendritic spine development;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	PAK4; p21-activated kinase 4 [EC:2.7.11.1]; K05734	p21 (RAC1) activated kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:16059]
ENSG00000123700	0.99	1.04	1.09	0.88	0.71	0.71	0.451580674163834	0.384108836005629	0.168157327860335	0.534086772456848	17:70168672-70180048:+	KCNJ2	44;GO:0005242,molecular_function inward rectifier potassium channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0010107,biological_process potassium ion import;GO:0014704,cellular_component intercalated disc;GO:0014861,biological_process regulation of skeletal muscle contraction via regulation of action potential;GO:0015467,molecular_function G-protein activated inward rectifier potassium channel activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030007,biological_process cellular potassium ion homeostasis;GO:0030315,cellular_component T-tubule;GO:0030425,cellular_component dendrite;GO:0031224,cellular_component intrinsic component of membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042802,molecular_function identical protein binding;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0051289,biological_process protein homotetramerization;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060075,biological_process regulation of resting membrane potential;GO:0060306,biological_process regulation of membrane repolarization;GO:0061337,biological_process cardiac conduction;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071805,biological_process potassium ion transmembrane transport;GO:0086001,biological_process cardiac muscle cell action potential;GO:0086002,biological_process cardiac muscle cell action potential involved in contraction;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:0086008,molecular_function voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0086011,biological_process membrane repolarization during action potential;GO:0086012,biological_process membrane depolarization during cardiac muscle cell action potential;GO:0086013,biological_process membrane repolarization during cardiac muscle cell action potential;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0090076,biological_process relaxation of skeletal muscle;GO:1901381,biological_process positive regulation of potassium ion transmembrane transport	NA	potassium voltage-gated channel subfamily J member 2 [Source:HGNC Symbol%3BAcc:HGNC:6263]
ENSG00000132254	32.56	39.08	35.72	32.06	37.00	29.76	0.128244643239322	5.35720553609367	0.168188361021457	0.534086772456848	11:6474682-6481479:-	ARFIP2	20;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006928,biological_process movement of cell or subcellular component;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0019904,molecular_function protein domain specific binding;GO:0030032,biological_process lamellipodium assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031529,biological_process ruffle organization;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034315,biological_process regulation of Arp2/3 complex-mediated actin nucleation;GO:0042802,molecular_function identical protein binding;GO:0045296,molecular_function cadherin binding;GO:0048365,molecular_function Rac GTPase binding;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	ADP ribosylation factor interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17160]
ENSG00000137764	16.87	13.18	16.90	18.25	16.55	17.49	-0.134441117150839	4.55693764422938	0.168190219409798	0.534086772456848	15:67542708-67807123:+	MAP2K5	43;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007507,biological_process heart development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030307,biological_process positive regulation of cell growth;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032147,biological_process activation of protein kinase activity;GO:0034115,biological_process negative regulation of heterotypic cell-cell adhesion;GO:0042981,biological_process regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045415,biological_process negative regulation of interleukin-8 biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0060761,biological_process negative regulation of response to cytokine stimulus;GO:0070375,biological_process ERK5 cascade;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071499,biological_process cellular response to laminar fluid shear stress;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:2000342,biological_process negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	MAP2K5, MEK5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]; K04463	mitogen-activated protein kinase kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:6845]
ENSG00000023041	33.96	34.86	33.86	37.80	36.47	36.17	-0.0945319164587193	5.47821433246546	0.168265248198739	0.534141179982299	10:112424427-112446917:-	ZDHHC6	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:19160]
ENSG00000143473	1.63	1.15	1.93	2.08	2.16	1.56	-0.267310783264493	2.52162824405532	0.168293414558187	0.534141179982299	1:210676822-211134180:-	KCNH1	44;GO:0000155,molecular_function phosphorelay sensor kinase activity;GO:0000160,biological_process phosphorelay signal transduction system;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005251,molecular_function delayed rectifier potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0007520,biological_process myoblast fusion;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0008289,molecular_function lipid binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031901,cellular_component early endosome membrane;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042127,biological_process regulation of cell proliferation;GO:0042391,biological_process regulation of membrane potential;GO:0042734,cellular_component presynaptic membrane;GO:0042995,cellular_component cell projection;GO:0043204,cellular_component perikaryon;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0055085,biological_process transmembrane transport;GO:0071277,biological_process cellular response to calcium ion;GO:0071805,biological_process potassium ion transmembrane transport;GO:1902936,molecular_function phosphatidylinositol bisphosphate binding	NA	potassium voltage-gated channel subfamily H member 1 [Source:HGNC Symbol%3BAcc:HGNC:6250]
ENSG00000129083	102.67	111.80	99.33	94.60	102.72	99.44	0.0916103001337169	8.1869262052758	0.168404830557572	0.53435817017156	11:14443439-14500027:-	COPB1	30;GO:0000139,cellular_component Golgi membrane;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030137,cellular_component COPI-coated vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	coatomer protein complex subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:2231]
ENSG00000105246	1.54	0.42	1.29	1.53	1.77	1.64	-0.517147433504146	0.155369736923558	0.168617585718504	0.534896522239662	19:4229497-4237531:+	EBI3	15;GO:0004896,molecular_function cytokine receptor activity;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006959,biological_process humoral immune response;GO:0016020,cellular_component membrane;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042088,biological_process T-helper 1 type immune response;GO:0042098,biological_process T cell proliferation;GO:0045078,biological_process positive regulation of interferon-gamma biosynthetic process;GO:0045523,molecular_function interleukin-27 receptor binding;GO:0046641,biological_process positive regulation of alpha-beta T cell proliferation	NA	Epstein-Barr virus induced 3 [Source:HGNC Symbol%3BAcc:HGNC:3129]
ENSG00000135740	3.62	4.09	3.93	3.62	3.33	3.50	0.161768765585342	3.33747370350134	0.168850864605924	0.535499688899675	16:67237682-67272190:+	SLC9A5	18;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0006885,biological_process regulation of pH;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015386,molecular_function potassium:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:0098719,biological_process sodium ion import across plasma membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	solute carrier family 9 member A5 [Source:HGNC Symbol%3BAcc:HGNC:11078]
ENSG00000104381	5.59	4.45	4.66	5.86	6.00	5.50	-0.215528642931791	2.56613434970164	0.169244018117545	0.536609431907798	8:74321129-74488872:+	GDAP1	15;GO:0000266,biological_process mitochondrial fission;GO:0004364,molecular_function glutathione transferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006749,biological_process glutathione metabolic process;GO:0008053,biological_process mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0032526,biological_process response to retinoic acid;GO:0071305,biological_process cellular response to vitamin D	NA	ganglioside induced differentiation associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15968]
ENSG00000148985	10.24	10.37	11.18	10.96	11.74	12.61	-0.139235388943639	4.01419944968067	0.169287242032622	0.536609431907798	11:3797723-3826371:+	PGAP2	16;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008565,molecular_function protein transporter activity;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	NA	post-GPI attachment to proteins 2 [Source:HGNC Symbol%3BAcc:HGNC:17893]
ENSG00000014824	49.32	44.21	47.14	48.25	52.17	50.98	-0.0920285973126637	6.39811198042739	0.169414759425624	0.536663645038592	4:41990471-42090457:+	SLC30A9	19;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005856,cellular_component cytoskeleton;GO:0006289,biological_process nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006829,biological_process zinc II ion transport;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0055085,biological_process transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	solute carrier family 30 member 9 [Source:HGNC Symbol%3BAcc:HGNC:1329]
ENSG00000111642	88.39	87.13	85.13	90.79	93.88	92.75	-0.0781757745016198	9.02898193577225	0.169446767320509	0.536663645038592	12:6570082-6607476:-	CHD4	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008017,molecular_function microtubule binding;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016581,cellular_component NuRD complex;GO:0016787,molecular_function hydrolase activity;GO:0031492,molecular_function nucleosomal DNA binding;GO:0032508,biological_process DNA duplex unwinding;GO:0032993,cellular_component protein-DNA complex;GO:0042826,molecular_function histone deacetylase binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0051225,biological_process spindle assembly;GO:0072553,biological_process terminal button organization;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	CHD4, MI2B; chromodomain-helicase-DNA-binding protein 4 [EC:3.6.4.12]; K11643	chromodomain helicase DNA binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:1919]
ENSG00000009335	35.60	37.18	37.19	34.51	35.48	34.47	0.0854407821498504	6.88997646144447	0.169494237178509	0.536663645038592	7:157138912-157269372:+	UBE3C	10;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0061630,molecular_function ubiquitin protein ligase activity	UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]; K10589	ubiquitin protein ligase E3C [Source:HGNC Symbol%3BAcc:HGNC:16803]
ENSG00000204344	15.29	16.71	18.40	15.19	14.08	16.62	0.144305545765638	4.15939765913609	0.169525980818587	0.536663645038592	6:31971090-31982821:+	STK19	9;GO:0000166,molecular_function nucleotide binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity	NA	serine/threonine kinase 19 [Source:HGNC Symbol%3BAcc:HGNC:11398]
ENSG00000135047	311.01	292.60	326.00	290.03	280.54	310.05	0.0903821476992323	8.31340732628476	0.16957010750168	0.536663645038592	9:87725518-87731393:+	CTSL	29;GO:0001968,molecular_function fibronectin binding;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0019882,biological_process antigen processing and presentation;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0022617,biological_process extracellular matrix disassembly;GO:0030574,biological_process collagen catabolic process;GO:0036021,cellular_component endolysosome lumen;GO:0042393,molecular_function histone binding;GO:0043202,cellular_component lysosomal lumen;GO:0043394,molecular_function proteoglycan binding;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0071888,biological_process macrophage apoptotic process;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:0097655,molecular_function serpin family protein binding	CTSL; cathepsin L [EC:3.4.22.15]; K01365	cathepsin L [Source:HGNC Symbol%3BAcc:HGNC:2537]
ENSG00000126858	25.20	27.44	25.32	28.07	27.20	28.35	-0.0926716485916168	5.93589202226595	0.169678006017279	0.536663645038592	17:32142453-32253374:+	RHOT1	26;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003924,molecular_function GTPase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007005,biological_process mitochondrion organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019725,biological_process cellular homeostasis;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0034640,biological_process establishment of mitochondrion localization by microtubule attachment;GO:0046872,molecular_function metal ion binding;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0097345,biological_process mitochondrial outer membrane permeabilization;GO:1902513,biological_process regulation of organelle transport along microtubule	RHOT1, ARHT1; mitochondrial Rho GTPase 1 [EC:3.6.5.-]; K07870	ras homolog family member T1 [Source:HGNC Symbol%3BAcc:HGNC:21168]
ENSG00000184220	42.62	43.41	40.97	47.06	42.47	47.80	-0.103339270246311	5.34436328982993	0.169724255259902	0.536663645038592	3:99817833-100181732:+	CMSS1	3;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0030686,cellular_component 90S preribosome	NA	cms1 ribosomal small subunit homolog (yeast) [Source:HGNC Symbol%3BAcc:HGNC:28666]
ENSG00000116752	56.50	60.88	54.41	58.79	60.45	67.09	-0.110111889304682	5.33808874173896	0.169757172803848	0.536663645038592	1:114567556-114581639:-	BCAS2	15;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005813,cellular_component centrosome;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	BCAS2; pre-mRNA-splicing factor SPF27; K12861	BCAS2%2C pre-mRNA processing factor [Source:HGNC Symbol%3BAcc:HGNC:975]
ENSG00000011332	0.60	1.10	0.79	1.09	0.99	1.29	-0.469438980318067	0.504882895290703	0.169772152603957	0.536663645038592	19:38211005-38229714:-	DPF1	9;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007399,biological_process nervous system development;GO:0046872,molecular_function metal ion binding;GO:0071565,cellular_component nBAF complex	NA	double PHD fingers 1 [Source:HGNC Symbol%3BAcc:HGNC:20225]
ENSG00000179041	25.28	23.48	27.42	26.74	28.61	27.93	-0.111531906206512	4.87422199237975	0.169852425840255	0.536663645038592	8:66429027-66430733:+	RRS1	18;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000794,cellular_component condensed nuclear chromosome;GO:0001650,cellular_component fibrillar center;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005783,cellular_component endoplasmic reticulum;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008097,molecular_function 5S rRNA binding;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902570,biological_process protein localization to nucleolus	NA	ribosome biogenesis regulator homolog [Source:HGNC Symbol%3BAcc:HGNC:17083]
ENSG00000160305	10.32	9.02	10.67	9.12	9.56	9.50	0.107558818059104	5.53150596229693	0.169854093773052	0.536663645038592	21:46458898-46569852:+	DIP2A	8;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007275,biological_process multicellular organism development;GO:0008152,biological_process metabolic process;GO:0009986,cellular_component cell surface;GO:0010629,biological_process negative regulation of gene expression;GO:0042981,biological_process regulation of apoptotic process	NA	disco interacting protein 2 homolog A [Source:HGNC Symbol%3BAcc:HGNC:17217]
ENSG00000138029	69.03	76.32	74.25	76.71	80.45	78.53	-0.0915795830754514	6.79910642699269	0.16985715087581	0.536663645038592	2:26243169-26290468:+	HADHB	23;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0003988,molecular_function acetyl-CoA C-acyltransferase activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016509,molecular_function long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0035965,biological_process cardiolipin acyl-chain remodeling;GO:0042645,cellular_component mitochondrial nucleoid;GO:0070062,cellular_component extracellular exosome	HADHB; acetyl-CoA acyltransferase [EC:2.3.1.16]; K07509	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein)%2C beta subunit [Source:HGNC Symbol%3BAcc:HGNC:4803]
ENSG00000020256	6.87	5.51	6.17	5.79	5.50	5.82	0.136945802803555	4.40044951711009	0.169866386961784	0.536663645038592	20:52051662-52204308:-	ZFP64	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	ZFP64 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:15940]
ENSG00000163393	7.23	5.01	7.89	8.35	6.42	9.04	-0.219980320087882	3.62021691466128	0.169959779772833	0.536822072855006	1:115976497-116070054:+	SLC22A15	8;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0015711,biological_process organic anion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 22 member 15 [Source:HGNC Symbol%3BAcc:HGNC:20301]
ENSG00000153237	1.39	1.57	1.53	1.52	2.16	1.89	-0.300988370291989	1.68577544964086	0.17000968510283	0.536843098748774	2:158171080-158456753:-	CCDC148	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 148 [Source:HGNC Symbol%3BAcc:HGNC:25191]
ENSG00000027075	1.31	1.31	1.89	1.82	2.38	1.49	-0.312463901611728	2.00511771904693	0.170100052033842	0.53686625680681	14:61187558-61550976:+	PRKCH	34;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0004699,molecular_function calcium-independent protein kinase C activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0010744,biological_process positive regulation of macrophage derived foam cell differentiation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017160,molecular_function Ral GTPase binding;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0034351,biological_process negative regulation of glial cell apoptotic process;GO:0035556,biological_process intracellular signal transduction;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0050861,biological_process positive regulation of B cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070528,biological_process protein kinase C signaling;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:2000810,biological_process regulation of bicellular tight junction assembly	NA	protein kinase C eta [Source:HGNC Symbol%3BAcc:HGNC:9403]
ENSG00000140497	30.29	31.02	31.69	26.76	31.41	28.83	0.107936157601156	5.19618474068361	0.17011575596272	0.53686625680681	15:74843729-74873365:-	SCAMP2	13;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055038,cellular_component recycling endosome membrane;GO:0070062,cellular_component extracellular exosome	NA	secretory carrier membrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:10564]
ENSG00000169609	15.88	12.87	15.94	13.97	13.44	13.26	0.159273508419154	3.80002940343478	0.170146769860468	0.53686625680681	15:82988440-83011641:-	C15orf40	NA	NA	chromosome 15 open reading frame 40 [Source:HGNC Symbol%3BAcc:HGNC:28443]
ENSG00000213402	1.60	2.47	2.50	3.63	2.58	2.62	-0.426766786401219	0.795513343977724	0.170362028232871	0.537373695426209	11:67435509-67438067:-	PTPRCAP	4;GO:0005886,cellular_component plasma membrane;GO:0006952,biological_process defense response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protein tyrosine phosphatase%2C receptor type C associated protein [Source:HGNC Symbol%3BAcc:HGNC:9667]
ENSG00000180694	23.30	20.08	20.89	19.43	20.21	20.08	0.122708670196534	4.58479865313138	0.170394172657501	0.537373695426209	8:90621994-90791632:-	TMEM64	11;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043462,biological_process regulation of ATPase activity;GO:0044339,biological_process canonical Wnt signaling pathway involved in osteoblast differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045780,biological_process positive regulation of bone resorption;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	transmembrane protein 64 [Source:HGNC Symbol%3BAcc:HGNC:25441]
ENSG00000135744	13.74	11.10	14.37	11.37	12.41	12.03	0.152197052178987	4.20240789001729	0.17052593050596	0.537647751608562	1:230702522-230714297:-	AGT	102;GO:0001558,biological_process regulation of cell growth;GO:0001819,biological_process positive regulation of cytokine production;GO:0001822,biological_process kidney development;GO:0001974,biological_process blood vessel remodeling;GO:0002003,biological_process angiotensin maturation;GO:0002016,biological_process regulation of blood volume by renin-angiotensin;GO:0002018,biological_process renin-angiotensin regulation of aldosterone production;GO:0002019,biological_process regulation of renal output by angiotensin;GO:0002027,biological_process regulation of heart rate;GO:0002034,biological_process regulation of blood vessel size by renin-angiotensin;GO:0003014,biological_process renal system process;GO:0003051,biological_process angiotensin-mediated drinking behavior;GO:0003081,biological_process regulation of systemic arterial blood pressure by renin-angiotensin;GO:0003331,biological_process positive regulation of extracellular matrix constituent secretion;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005179,molecular_function hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007199,biological_process G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007202,biological_process activation of phospholipase C activity;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007263,biological_process nitric oxide mediated signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0008083,molecular_function growth factor activity;GO:0008217,biological_process regulation of blood pressure;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010536,biological_process positive regulation of activation of Janus kinase activity;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0010744,biological_process positive regulation of macrophage derived foam cell differentiation;GO:0010873,biological_process positive regulation of cholesterol esterification;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0014061,biological_process regulation of norepinephrine secretion;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014824,biological_process artery smooth muscle contraction;GO:0014873,biological_process response to muscle activity involved in regulation of muscle adaptation;GO:0016525,biological_process negative regulation of angiogenesis;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019229,biological_process regulation of vasoconstriction;GO:0030308,biological_process negative regulation of cell growth;GO:0031701,molecular_function angiotensin receptor binding;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0031703,molecular_function type 2 angiotensin receptor binding;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0033864,biological_process positive regulation of NAD(P)H oxidase activity;GO:0034104,biological_process negative regulation of tissue remodeling;GO:0034374,biological_process low-density lipoprotein particle remodeling;GO:0035411,biological_process catenin import into nucleus;GO:0035813,biological_process regulation of renal sodium excretion;GO:0035815,biological_process positive regulation of renal sodium excretion;GO:0042127,biological_process regulation of cell proliferation;GO:0042310,biological_process vasoconstriction;GO:0042311,biological_process vasodilation;GO:0042981,biological_process regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045777,biological_process positive regulation of blood pressure;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048144,biological_process fibroblast proliferation;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048659,biological_process smooth muscle cell proliferation;GO:0050663,biological_process cytokine secretion;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050880,biological_process regulation of blood vessel size;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051387,biological_process negative regulation of neurotrophin TRK receptor signaling pathway;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051924,biological_process regulation of calcium ion transport;GO:0051969,biological_process regulation of transmission of nerve impulse;GO:0061049,biological_process cell growth involved in cardiac muscle cell development;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070471,biological_process uterine smooth muscle contraction;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0072562,cellular_component blood microparticle;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1901201,biological_process regulation of extracellular matrix assembly;GO:1903598,biological_process positive regulation of gap junction assembly;GO:1903779,biological_process regulation of cardiac conduction;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:1905010,biological_process positive regulation of L-lysine import into cell;GO:1905589,biological_process positive regulation of L-arginine import across plasma membrane;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	AGT, SERPINA8; angiotensinogen; K09821	angiotensinogen [Source:HGNC Symbol%3BAcc:HGNC:333]
ENSG00000105928	66.67	58.67	68.20	77.56	60.10	75.44	-0.126083694190478	6.87756102458085	0.170567698850763	0.537647751608562	7:24698352-24758113:-	DFNA5	9;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007605,biological_process sensory perception of sound;GO:0008285,biological_process negative regulation of cell proliferation;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0060113,biological_process inner ear receptor cell differentiation;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	NA	DFNA5%2C deafness associated tumor suppressor [Source:HGNC Symbol%3BAcc:HGNC:2810]
ENSG00000172613	13.31	16.62	15.87	15.77	19.53	16.13	-0.160175566869596	4.25785559251483	0.1707054653313	0.53767518415496	11:67317870-67398410:+	RAD9A	25;GO:0000075,biological_process cell cycle checkpoint;GO:0000076,biological_process DNA replication checkpoint;GO:0000077,biological_process DNA damage checkpoint;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0008853,molecular_function exodeoxyribonuclease III activity;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030896,cellular_component checkpoint clamp complex;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0042826,molecular_function histone deacetylase binding;GO:0071479,biological_process cellular response to ionizing radiation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902231,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]; K10994	RAD9 checkpoint clamp component A [Source:HGNC Symbol%3BAcc:HGNC:9827]
ENSG00000162191	74.54	69.38	72.36	70.28	66.32	68.65	0.0890778248846476	6.15472584013527	0.170736522007853	0.53767518415496	11:62676497-62679117:-	UBXN1	22;GO:0000502,cellular_component proteasome complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0030425,cellular_component dendrite;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031593,molecular_function polyubiquitin binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0036435,molecular_function K48-linked polyubiquitin binding;GO:0043025,cellular_component neuronal cell body;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051117,molecular_function ATPase binding;GO:0071796,molecular_function K6-linked polyubiquitin binding;GO:1903094,biological_process negative regulation of protein K48-linked deubiquitination;GO:1904293,biological_process negative regulation of ERAD pathway;GO:2000157,biological_process negative regulation of ubiquitin-specific protease activity	NA	UBX domain protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18402]
ENSG00000138795	6.41	4.20	5.01	4.60	3.55	5.10	0.258765284424763	2.76070459244096	0.170741394263866	0.53767518415496	4:108047544-108168956:-	LEF1	105;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001569,biological_process patterning of blood vessels;GO:0001649,biological_process osteoblast differentiation;GO:0001755,biological_process neural crest cell migration;GO:0001756,biological_process somitogenesis;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001944,biological_process vasculature development;GO:0002040,biological_process sprouting angiogenesis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008301,molecular_function DNA binding, bending;GO:0010628,biological_process positive regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016055,biological_process Wnt signaling pathway;GO:0016202,biological_process regulation of striated muscle tissue development;GO:0021542,biological_process dentate gyrus development;GO:0021766,biological_process hippocampus development;GO:0021854,biological_process hypothalamus development;GO:0021861,biological_process forebrain radial glial cell differentiation;GO:0021873,biological_process forebrain neuroblast division;GO:0021879,biological_process forebrain neuron differentiation;GO:0021943,biological_process formation of radial glial scaffolds;GO:0022407,biological_process regulation of cell-cell adhesion;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030223,biological_process neutrophil differentiation;GO:0030284,molecular_function estrogen receptor activity;GO:0030307,biological_process positive regulation of cell growth;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030331,molecular_function estrogen receptor binding;GO:0030335,biological_process positive regulation of cell migration;GO:0030509,biological_process BMP signaling pathway;GO:0030854,biological_process positive regulation of granulocyte differentiation;GO:0030879,biological_process mammary gland development;GO:0032696,biological_process negative regulation of interleukin-13 production;GO:0032713,biological_process negative regulation of interleukin-4 production;GO:0032714,biological_process negative regulation of interleukin-5 production;GO:0032993,cellular_component protein-DNA complex;GO:0033153,biological_process T cell receptor V(D)J recombination;GO:0035326,molecular_function enhancer binding;GO:0042100,biological_process B cell proliferation;GO:0042393,molecular_function histone binding;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042826,molecular_function histone deacetylase binding;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043392,biological_process negative regulation of DNA binding;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043586,biological_process tongue development;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0043966,biological_process histone H3 acetylation;GO:0043967,biological_process histone H4 acetylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045063,biological_process T-helper 1 cell differentiation;GO:0045295,molecular_function gamma-catenin binding;GO:0045843,biological_process negative regulation of striated muscle tissue development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046632,biological_process alpha-beta T cell differentiation;GO:0048069,biological_process eye pigmentation;GO:0048341,biological_process paraxial mesoderm formation;GO:0048468,biological_process cell development;GO:0048747,biological_process muscle fiber development;GO:0050909,biological_process sensory perception of taste;GO:0060021,biological_process palate development;GO:0060033,biological_process anatomical structure regression;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060325,biological_process face morphogenesis;GO:0060326,biological_process cell chemotaxis;GO:0060561,biological_process apoptotic process involved in morphogenesis;GO:0060710,biological_process chorio-allantoic fusion;GO:0061153,biological_process trachea gland development;GO:0070016,molecular_function armadillo repeat domain binding;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071353,biological_process cellular response to interleukin-4;GO:0071864,biological_process positive regulation of cell proliferation in bone marrow;GO:0071866,biological_process negative regulation of apoptotic process in bone marrow;GO:0071895,biological_process odontoblast differentiation;GO:0071899,biological_process negative regulation of estrogen receptor binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1902262,biological_process apoptotic process involved in patterning of blood vessels;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:1990907,cellular_component beta-catenin-TCF complex	LEF1; lymphoid enhancer-binding factor 1; K04492	lymphoid enhancer binding factor 1 [Source:HGNC Symbol%3BAcc:HGNC:6551]
ENSG00000183520	47.92	47.59	52.85	50.01	43.67	44.84	0.112695045146798	5.18854840687679	0.170749663734702	0.53767518415496	1:38009257-38024824:+	UTP11	12;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0007399,biological_process nervous system development;GO:0032040,cellular_component small-subunit processome;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0043065,biological_process positive regulation of apoptotic process	NA	UTP11%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:24329]
ENSG00000095951	7.41	6.65	7.48	7.19	6.44	6.65	0.101918194759886	5.86391355187706	0.170805912486658	0.537715899491981	6:12008761-12164999:+	HIVEP1	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001206,molecular_function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0016604,cellular_component nuclear body;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0046872,molecular_function metal ion binding	NA	human immunodeficiency virus type I enhancer binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4920]
ENSG00000138085	171.84	166.23	179.08	166.09	152.31	171.01	0.0918306890790625	7.16193869034295	0.170941075581174	0.538004962269046	2:27212026-27217178:+	ATRAID	15;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030501,biological_process positive regulation of bone mineralization;GO:0033689,biological_process negative regulation of osteoblast proliferation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:1903363,biological_process negative regulation of cellular protein catabolic process	NA	all-trans retinoic acid induced differentiation factor [Source:HGNC Symbol%3BAcc:HGNC:24090]
ENSG00000116678	8.91	10.61	9.99	10.15	10.68	11.29	-0.115627105149912	5.27518537623763	0.170988025334305	0.538016313935291	1:65420651-65641559:+	LEPR	29;GO:0001525,biological_process angiogenesis;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004896,molecular_function cytokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006112,biological_process energy reserve metabolic process;GO:0006909,biological_process phagocytosis;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008203,biological_process cholesterol metabolic process;GO:0010507,biological_process negative regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0019953,biological_process sexual reproduction;GO:0030217,biological_process T cell differentiation;GO:0033210,biological_process leptin-mediated signaling pathway;GO:0038021,molecular_function leptin receptor activity;GO:0042593,biological_process glucose homeostasis;GO:0043235,cellular_component receptor complex;GO:0044321,biological_process response to leptin;GO:0045721,biological_process negative regulation of gluconeogenesis;GO:0046850,biological_process regulation of bone remodeling;GO:0051346,biological_process negative regulation of hydrolase activity;GO:0060259,biological_process regulation of feeding behavior;GO:0097009,biological_process energy homeostasis;GO:0098868,biological_process bone growth;GO:2000505,biological_process regulation of energy homeostasis	LEPR, CD295; leptin receptor; K05062	leptin receptor [Source:HGNC Symbol%3BAcc:HGNC:6554]
ENSG00000116251	1148.94	1152.71	1143.47	1255.36	1179.60	1234.67	-0.0793688923425973	8.90182707038368	0.171097546337111	0.538224491303232	1:6181268-6209389:-	RPL22	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008201,molecular_function heparin binding;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	RP-L22e, RPL22; large subunit ribosomal protein L22e; K02891	ribosomal protein L22 [Source:HGNC Symbol%3BAcc:HGNC:10315]
ENSG00000025770	19.29	20.06	17.39	21.59	20.06	19.92	-0.109337326137931	5.29036373707968	0.17123919842868	0.538520095654701	22:50508215-50523472:+	NCAPH2	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030261,biological_process chromosome condensation;GO:0045171,cellular_component intercellular bridge	NA	non-SMC condensin II complex subunit H2 [Source:HGNC Symbol%3BAcc:HGNC:25071]
ENSG00000180953	8.34	11.29	9.63	6.32	8.00	8.31	0.360692319230442	1.12461943870747	0.171408543993588	0.538520095654701	15:79898839-79923702:-	ST20	NA	NA	suppressor of tumorigenicity 20 [Source:HGNC Symbol%3BAcc:HGNC:33520]
ENSG00000185774	1.73	2.44	1.58	1.38	1.39	1.58	0.380540230362824	0.827810267617617	0.171419497437143	0.538520095654701	4:20728615-21948799:-	KCNIP4	20;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0046872,molecular_function metal ion binding;GO:0061337,biological_process cardiac conduction;GO:0065009,biological_process regulation of molecular function;GO:0071805,biological_process potassium ion transmembrane transport;GO:0072659,biological_process protein localization to plasma membrane;GO:1901379,biological_process regulation of potassium ion transmembrane transport	NA	potassium voltage-gated channel interacting protein 4 [Source:HGNC Symbol%3BAcc:HGNC:30083]
ENSG00000072071	2.67	2.45	2.78	1.88	2.67	2.46	0.189556294448493	3.50253984329283	0.171425682966828	0.538520095654701	19:14147742-14206187:-	ADGRL1	25;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016524,molecular_function latrotoxin receptor activity;GO:0030054,cellular_component cell junction;GO:0030246,molecular_function carbohydrate binding;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0042734,cellular_component presynaptic membrane;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051965,biological_process positive regulation of synapse assembly;GO:0090129,biological_process positive regulation of synapse maturation	NA	adhesion G protein-coupled receptor L1 [Source:HGNC Symbol%3BAcc:HGNC:20973]
ENSG00000172456	4.44	3.63	3.92	4.20	3.01	3.15	0.231686131641544	2.75221276761233	0.171446137543393	0.538520095654701	1:59296637-59810647:+	FGGY	12;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005623,cellular_component cell;GO:0005975,biological_process carbohydrate metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019150,molecular_function D-ribulokinase activity;GO:0019321,biological_process pentose metabolic process;GO:0046835,biological_process carbohydrate phosphorylation;GO:0070050,biological_process neuron cellular homeostasis	NA	FGGY carbohydrate kinase domain containing [Source:HGNC Symbol%3BAcc:HGNC:25610]
ENSG00000142065	1.49	1.67	1.88	1.72	2.41	2.14	-0.305257725380579	1.67411799513339	0.171451818096139	0.538520095654701	19:36334452-36379199:-	ZFP14	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP14 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:29312]
ENSG00000075336	25.82	28.88	25.72	22.37	25.63	25.95	0.126361520183787	4.48642752546366	0.17154180947772	0.538544709166223	18:74148510-74160530:+	TIMM21	12;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	translocase of inner mitochondrial membrane 21 [Source:HGNC Symbol%3BAcc:HGNC:25010]
ENSG00000169762	7.86	7.33	7.89	8.33	8.53	8.80	-0.136786672685441	3.83622602662526	0.171547677719563	0.538544709166223	4:16160504-16227410:-	TAPT1	23;GO:0001503,biological_process ossification;GO:0001701,biological_process in utero embryonic development;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0009791,biological_process post-embryonic development;GO:0014032,biological_process neural crest cell development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016520,molecular_function growth hormone-releasing hormone receptor activity;GO:0030030,biological_process cell projection organization;GO:0030154,biological_process cell differentiation;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045724,biological_process positive regulation of cilium assembly;GO:0048706,biological_process embryonic skeletal system development;GO:0051216,biological_process cartilage development;GO:0061036,biological_process positive regulation of cartilage development;GO:1903012,biological_process positive regulation of bone development	NA	transmembrane anterior posterior transformation 1 [Source:HGNC Symbol%3BAcc:HGNC:26887]
ENSG00000110944	2.37	1.69	2.08	1.85	1.07	1.36	0.543445516378064	0.188922764790996	0.171589811065207	0.538544709166223	12:56334173-56340410:+	IL23A	44;GO:0001916,biological_process positive regulation of T cell mediated cytotoxicity;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0002827,biological_process positive regulation of T-helper 1 type immune response;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0010536,biological_process positive regulation of activation of Janus kinase activity;GO:0032693,biological_process negative regulation of interleukin-10 production;GO:0032725,biological_process positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0032740,biological_process positive regulation of interleukin-17 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032816,biological_process positive regulation of natural killer cell activation;GO:0032819,biological_process positive regulation of natural killer cell proliferation;GO:0034105,biological_process positive regulation of tissue remodeling;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042098,biological_process T cell proliferation;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0042509,biological_process regulation of tyrosine phosphorylation of STAT protein;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0043382,biological_process positive regulation of memory T cell differentiation;GO:0045087,biological_process innate immune response;GO:0045519,molecular_function interleukin-23 receptor binding;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048771,biological_process tissue remodeling;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0051135,biological_process positive regulation of NK T cell activation;GO:0051142,biological_process positive regulation of NK T cell proliferation;GO:0051607,biological_process defense response to virus;GO:0070743,cellular_component interleukin-23 complex;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:2000318,biological_process positive regulation of T-helper 17 type immune response;GO:2000330,biological_process positive regulation of T-helper 17 cell lineage commitment	IL23A; interleukin 23 subunit alpha; K05426	interleukin 23 subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:15488]
ENSG00000169375	22.71	21.30	23.69	20.03	22.53	21.34	0.0969235792271156	6.43036321755815	0.171693995206158	0.53863930900104	15:75369378-75455842:-	SIN3A	53;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000776,cellular_component kinetochore;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001701,biological_process in utero embryonic development;GO:0002218,biological_process activation of innate immune response;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006476,biological_process protein deacetylation;GO:0007568,biological_process aging;GO:0008134,molecular_function transcription factor binding;GO:0010243,biological_process response to organonitrogen compound;GO:0010817,biological_process regulation of hormone levels;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016575,biological_process histone deacetylation;GO:0016580,cellular_component Sin3 complex;GO:0017053,cellular_component transcriptional repressor complex;GO:0019216,biological_process regulation of lipid metabolic process;GO:0031937,biological_process positive regulation of chromatin silencing;GO:0032403,molecular_function protein complex binding;GO:0033558,molecular_function protein deacetylase activity;GO:0034613,biological_process cellular protein localization;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043619,biological_process regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process;GO:0051595,biological_process response to methylglyoxal;GO:0071333,biological_process cellular response to glucose stimulus;GO:1900181,biological_process negative regulation of protein localization to nucleus;GO:1901675,biological_process negative regulation of histone H3-K27 acetylation;GO:1903351,biological_process cellular response to dopamine;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding	SIN3A; paired amphipathic helix protein Sin3a; K11644	SIN3 transcription regulator family member A [Source:HGNC Symbol%3BAcc:HGNC:19353]
ENSG00000132823	47.33	48.98	50.66	55.56	47.19	57.39	-0.113108289334402	5.49335318064182	0.171736090389429	0.53863930900104	20:44196495-44210791:-	OSER1	NA	NA	oxidative stress responsive serine rich 1 [Source:HGNC Symbol%3BAcc:HGNC:16105]
ENSG00000124786	32.11	33.44	34.08	26.82	34.74	30.69	0.122652994305939	5.27109905720815	0.171750131718853	0.53863930900104	6:8413067-8435483:-	SLC35B3	11;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0046964,molecular_function 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity;GO:0050428,biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0055085,biological_process transmembrane transport;GO:1902559,biological_process 3'-phospho-5'-adenylyl sulfate transmembrane transport	NA	solute carrier family 35 member B3 [Source:HGNC Symbol%3BAcc:HGNC:21601]
ENSG00000188316	0.65	1.03	0.56	0.61	0.47	0.54	0.439401158136667	0.466830505154092	0.171836207730076	0.538773136285283	10:116849511-116911788:+	ENO4	8;GO:0000015,cellular_component phosphopyruvate hydratase complex;GO:0000287,molecular_function magnesium ion binding;GO:0003674,molecular_function molecular_function;GO:0004634,molecular_function phosphopyruvate hydratase activity;GO:0005575,cellular_component cellular_component;GO:0006096,biological_process glycolytic process;GO:0008150,biological_process biological_process;GO:0016829,molecular_function lyase activity	NA	enolase family member 4 [Source:HGNC Symbol%3BAcc:HGNC:31670]
ENSG00000146067	15.36	13.45	15.47	14.42	13.86	13.32	0.107250277655305	5.50765073576774	0.171958297364416	0.5390197841375	5:177519787-177554541:-	FAM193B	4;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm	NA	family with sequence similarity 193 member B [Source:HGNC Symbol%3BAcc:HGNC:25524]
ENSG00000126777	124.09	123.61	126.06	116.40	120.42	120.42	0.0771272606423726	9.0322264273719	0.172123181873497	0.539400418226639	14:55559071-55701526:+	KTN1	15;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007018,biological_process microtubule-based movement;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019894,molecular_function kinesin binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045296,molecular_function cadherin binding	NA	kinectin 1 [Source:HGNC Symbol%3BAcc:HGNC:6467]
ENSG00000103769	159.78	169.75	156.97	153.56	155.90	151.60	0.0877771384538844	6.6793806811139	0.172239930322125	0.539630049239914	15:65726053-65891991:+	RAB11A	62;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0000922,cellular_component spindle pole;GO:0003091,biological_process renal water homeostasis;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005771,cellular_component multivesicular body;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005813,cellular_component centrosome;GO:0005828,cellular_component kinetochore microtubule;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008017,molecular_function microtubule binding;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010796,biological_process regulation of multivesicular body size;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030133,cellular_component transport vesicle;GO:0030424,cellular_component axon;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030953,biological_process astral microtubule organization;GO:0031175,biological_process neuron projection development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0031982,cellular_component vesicle;GO:0032154,cellular_component cleavage furrow;GO:0032402,biological_process melanosome transport;GO:0036258,biological_process multivesicular body assembly;GO:0043234,cellular_component protein complex;GO:0043687,biological_process post-translational protein modification;GO:0045335,cellular_component phagocytic vesicle;GO:0045773,biological_process positive regulation of axon extension;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048227,biological_process plasma membrane to endosome transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051223,biological_process regulation of protein transport;GO:0051650,biological_process establishment of vesicle localization;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0060627,biological_process regulation of vesicle-mediated transport;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072594,biological_process establishment of protein localization to organelle;GO:0072659,biological_process protein localization to plasma membrane;GO:0090150,biological_process establishment of protein localization to membrane;GO:0090307,biological_process mitotic spindle assembly;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0098837,cellular_component postsynaptic recycling endosome;GO:0098887,biological_process neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:1990182,biological_process exosomal secretion	RAB11A; Ras-related protein Rab-11A; K07904	RAB11A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9760]
ENSG00000178177	3.48	3.66	3.13	3.45	3.79	4.07	-0.130796864895073	4.62421243468152	0.172370076498434	0.539801249223505	4:17841198-18021876:-	LCORL	7;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter	NA	ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol%3BAcc:HGNC:30776]
ENSG00000156675	5.84	6.04	6.13	6.54	6.80	6.29	-0.11318219773084	4.61528303420809	0.17238154772593	0.539801249223505	8:37858617-37899467:-	RAB11FIP1	13;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045055,biological_process regulated exocytosis;GO:0055037,cellular_component recycling endosome;GO:0070164,biological_process negative regulation of adiponectin secretion	RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5; K12484	RAB11 family interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30265]
ENSG00000090054	59.34	59.52	57.91	65.81	61.65	61.91	-0.0878701147002873	6.44168443747325	0.172521365450052	0.539928346839034	9:92031998-92115384:-	SPTLC1	21;GO:0003824,molecular_function catalytic activity;GO:0004758,molecular_function serine C-palmitoyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006686,biological_process sphingomyelin biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017059,cellular_component serine C-palmitoyltransferase complex;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0035339,cellular_component SPOTS complex;GO:0046511,biological_process sphinganine biosynthetic process;GO:0046512,biological_process sphingosine biosynthetic process;GO:0046513,biological_process ceramide biosynthetic process;GO:1904504,biological_process positive regulation of lipophagy	SPT; serine palmitoyltransferase [EC:2.3.1.50]; K00654	serine palmitoyltransferase long chain base subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:11277]
ENSG00000128191	13.28	13.35	13.33	12.30	11.81	13.28	0.106100648854216	4.90959668538859	0.172526425545816	0.539928346839034	22:20080231-20111877:+	DGCR8	18;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004525,molecular_function ribonuclease III activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0010586,biological_process miRNA metabolic process;GO:0020037,molecular_function heme binding;GO:0031053,biological_process primary miRNA processing;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0070877,cellular_component microprocessor complex;GO:0070878,molecular_function primary miRNA binding;GO:0072091,biological_process regulation of stem cell proliferation;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	DGCR8%2C microprocessor complex subunit [Source:HGNC Symbol%3BAcc:HGNC:2847]
ENSG00000072958	34.18	36.14	30.25	29.94	33.99	29.55	0.114723635767312	5.53223850999353	0.172601168505767	0.539928346839034	19:16197577-16245907:+	AP1M1	25;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030131,cellular_component clathrin adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032438,biological_process melanosome organization;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035579,cellular_component specific granule membrane;GO:0035646,biological_process endosome to melanosome transport;GO:0043312,biological_process neutrophil degranulation;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0070062,cellular_component extracellular exosome	AP1M; AP-1 complex subunit mu; K12393	adaptor related protein complex 1 mu 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:13667]
ENSG00000041802	15.53	15.25	14.08	16.43	15.65	16.56	-0.106708492736048	4.96088086512794	0.172642727179084	0.539928346839034	3:194640787-194672477:-	LSG1	15;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015030,cellular_component Cajal body;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0042254,biological_process ribosome biogenesis;GO:0051168,biological_process nuclear export	LSG1; large subunit GTPase 1 [EC:3.6.1.-]; K14539	large 60S subunit nuclear export GTPase 1 [Source:HGNC Symbol%3BAcc:HGNC:25652]
ENSG00000049167	9.16	7.88	10.10	10.15	10.41	10.24	-0.159513886803415	3.54629942739945	0.172702621808569	0.539928346839034	5:60873830-60945073:-	ERCC8	21;GO:0000109,cellular_component nucleotide-excision repair complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0009411,biological_process response to UV;GO:0010165,biological_process response to X-ray;GO:0016363,cellular_component nuclear matrix;GO:0016567,biological_process protein ubiquitination;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0032403,molecular_function protein complex binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0043687,biological_process post-translational protein modification;GO:0051865,biological_process protein autoubiquitination	ERCC8, CKN1, CSA; DNA excision repair protein ERCC-8; K10570	ERCC excision repair 8%2C CSA ubiquitin ligase complex subunit [Source:HGNC Symbol%3BAcc:HGNC:3439]
ENSG00000164620	9.94	10.76	9.64	8.67	8.95	9.44	0.168767310039746	3.16428841366574	0.172764817635036	0.539928346839034	5:141636949-141641077:+	RELL2	8;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005886,cellular_component plasma membrane;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	RELT like 2 [Source:HGNC Symbol%3BAcc:HGNC:26902]
ENSG00000162511	13.39	9.12	12.55	17.43	10.13	14.94	-0.257343405171338	3.38045372857624	0.172775002440186	0.539928346839034	1:30732468-30757820:-	LAPTM5	8;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1990830,biological_process cellular response to leukemia inhibitory factor	LAPTM; lysosomal-associated transmembrane protein; K12387	lysosomal protein transmembrane 5 [Source:HGNC Symbol%3BAcc:HGNC:29612]
ENSG00000140451	5.71	5.84	5.64	6.05	7.66	5.78	-0.168976887094868	3.75159717878524	0.172825059876123	0.539928346839034	15:64815631-64825668:-	PIF1	27;GO:0000002,biological_process mitochondrial genome maintenance;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000723,biological_process telomere maintenance;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005657,cellular_component replication fork;GO:0005739,cellular_component mitochondrion;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010521,molecular_function telomerase inhibitor activity;GO:0016787,molecular_function hydrolase activity;GO:0017116,molecular_function single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0032204,biological_process regulation of telomere maintenance;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032508,biological_process DNA duplex unwinding;GO:0033682,molecular_function ATP-dependent 5'-3' DNA/RNA helicase activity;GO:0042162,molecular_function telomeric DNA binding;GO:0043141,molecular_function ATP-dependent 5'-3' DNA helicase activity;GO:0044806,biological_process G-quadruplex DNA unwinding;GO:0051974,biological_process negative regulation of telomerase activity	NA	PIF1 5'-to-3' DNA helicase [Source:HGNC Symbol%3BAcc:HGNC:26220]
ENSG00000196214	17.54	18.11	18.19	16.37	16.97	17.06	0.105571588158737	4.75518343105908	0.172849547619442	0.539928346839034	19:52269570-52296046:+	ZNF766	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 766 [Source:HGNC Symbol%3BAcc:HGNC:28063]
ENSG00000115232	1.67	1.59	1.70	1.56	1.16	1.53	0.233739063590144	2.30820983987024	0.172862871609313	0.539928346839034	2:181457201-181536187:+	ITGA4	39;GO:0001968,molecular_function fibronectin binding;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0003366,biological_process cell-matrix adhesion involved in ameboidal cell migration;GO:0003823,molecular_function antigen binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009986,cellular_component cell surface;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019960,molecular_function C-X3-C chemokine binding;GO:0030183,biological_process B cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0034669,cellular_component integrin alpha4-beta7 complex;GO:0035987,biological_process endodermal cell differentiation;GO:0043113,biological_process receptor clustering;GO:0046872,molecular_function metal ion binding;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0050901,biological_process leukocyte tethering or rolling;GO:0050904,biological_process diapedesis;GO:0070062,cellular_component extracellular exosome;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0090074,biological_process negative regulation of protein homodimerization activity;GO:0098657,biological_process import into cell;GO:1903039,biological_process positive regulation of leukocyte cell-cell adhesion;GO:1903238,biological_process positive regulation of leukocyte tethering or rolling;GO:1990405,molecular_function protein antigen binding;GO:1990771,biological_process clathrin-mediated extracellular exosome endocytosis;GO:2000406,biological_process positive regulation of T cell migration	ITGA4, CD49d; integrin alpha 4; K06483	integrin subunit alpha 4 [Source:HGNC Symbol%3BAcc:HGNC:6140]
ENSG00000188785	7.10	5.75	6.14	6.55	7.70	7.21	-0.156512803199093	3.76052382174867	0.17290060248813	0.539928346839034	19:57389849-57402992:+	ZNF548	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 548 [Source:HGNC Symbol%3BAcc:HGNC:26561]
ENSG00000146701	177.39	193.08	183.29	169.84	184.39	170.28	0.0893166198587844	7.5366351004354	0.173032269460748	0.540191388019807	7:76048050-76067508:+	MDH2	25;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006108,biological_process malate metabolic process;GO:0006475,biological_process internal protein amino acid acetylation;GO:0006734,biological_process NADH metabolic process;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016615,molecular_function malate dehydrogenase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030060,molecular_function L-malate dehydrogenase activity;GO:0043209,cellular_component myelin sheath;GO:0043621,molecular_function protein self-association;GO:0046554,molecular_function malate dehydrogenase (NADP+) activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	MDH2; malate dehydrogenase [EC:1.1.1.37]; K00026	malate dehydrogenase 2 [Source:HGNC Symbol%3BAcc:HGNC:6971]
ENSG00000127666	7.90	7.87	7.58	7.64	6.75	7.04	0.134851850330804	4.00785275830446	0.173078435380905	0.540191388019807	19:4815931-4831704:-	TICAM1	43;GO:0002281,biological_process macrophage activation involved in immune response;GO:0002376,biological_process immune system process;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0010008,cellular_component endosome membrane;GO:0010508,biological_process positive regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0019901,molecular_function protein kinase binding;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032092,biological_process positive regulation of protein binding;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032496,biological_process response to lipopolysaccharide;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032816,biological_process positive regulation of natural killer cell activation;GO:0034128,biological_process negative regulation of MyD88-independent toll-like receptor signaling pathway;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043330,biological_process response to exogenous dsRNA;GO:0043496,biological_process regulation of protein homodimerization activity;GO:0045080,biological_process positive regulation of chemokine biosynthetic process;GO:0045087,biological_process innate immune response;GO:0045359,biological_process positive regulation of interferon-beta biosynthetic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0050871,biological_process positive regulation of B cell activation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0070266,biological_process necroptotic process;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0097190,biological_process apoptotic signaling pathway;GO:0097342,cellular_component ripoptosome;GO:0140052,Biological_Process cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response	TRIF; toll-like receptor adapter molecule 1; K05842	toll like receptor adaptor molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:18348]
ENSG00000148671	35.31	29.34	42.61	46.30	36.26	43.18	-0.206312000269228	3.18187084868474	0.173115390440892	0.540191388019807	10:86968191-86983934:+	ADIRF	13;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070062,cellular_component extracellular exosome;GO:0071478,biological_process cellular response to radiation;GO:0072719,biological_process cellular response to cisplatin;GO:2001023,biological_process regulation of response to drug	NA	adipogenesis regulatory factor [Source:HGNC Symbol%3BAcc:HGNC:24043]
ENSG00000198517	18.07	15.89	17.58	15.96	15.36	14.54	0.188808756542358	2.9591654888731	0.17331109309616	0.540579786391065	7:1530713-1543043:+	MAFK	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001221,molecular_function transcription cofactor binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0007596,biological_process blood coagulation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0071535,molecular_function RING-like zinc finger domain binding	NA	MAF bZIP transcription factor K [Source:HGNC Symbol%3BAcc:HGNC:6782]
ENSG00000197905	18.04	15.39	17.48	18.84	19.71	17.54	-0.120205115023121	4.58696623635793	0.173326959625911	0.540579786391065	12:2959329-3040673:+	TEAD4	18;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007517,biological_process muscle organ development;GO:0035329,biological_process hippo signaling;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048568,biological_process embryonic organ development	TEAD; transcriptional enhancer factor; K09448	TEA domain transcription factor 4 [Source:HGNC Symbol%3BAcc:HGNC:11717]
ENSG00000114346	44.25	47.25	41.46	46.02	52.00	45.76	-0.102228624419117	7.09543622080094	0.173467598179623	0.540623409756044	3:172750681-172821474:+	ECT2	45;GO:0000902,biological_process cell morphogenesis;GO:0000910,biological_process cytokinesis;GO:0004871,molecular_function signal transducer activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0015031,biological_process protein transport;GO:0017048,molecular_function Rho GTPase binding;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0032147,biological_process activation of protein kinase activity;GO:0032154,cellular_component cleavage furrow;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045859,biological_process regulation of protein kinase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051260,biological_process protein homooligomerization;GO:0051301,biological_process cell division;GO:0051988,biological_process regulation of attachment of spindle microtubules to kinetochore;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070830,biological_process bicellular tight junction assembly;GO:0071277,biological_process cellular response to calcium ion;GO:0071479,biological_process cellular response to ionizing radiation;GO:0072686,cellular_component mitotic spindle;GO:0090630,biological_process activation of GTPase activity;GO:0097149,cellular_component centralspindlin complex	NA	epithelial cell transforming 2 [Source:HGNC Symbol%3BAcc:HGNC:3155]
ENSG00000134198	39.31	41.80	37.97	43.82	51.13	37.76	-0.145715734457724	4.80523762624028	0.173503276342418	0.540623409756044	1:115048010-115089500:-	TSPAN2	14;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007420,biological_process brain development;GO:0014002,biological_process astrocyte development;GO:0014005,biological_process microglia development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042552,biological_process myelination;GO:0043209,cellular_component myelin sheath;GO:0048709,biological_process oligodendrocyte differentiation;GO:0061564,biological_process axon development	NA	tetraspanin 2 [Source:HGNC Symbol%3BAcc:HGNC:20659]
ENSG00000124702	56.59	58.87	53.32	60.50	61.22	59.28	-0.0911368461438127	6.09787373955136	0.173509091749315	0.540623409756044	6:43014102-43021298:+	KLHDC3	8;GO:0000790,cellular_component nuclear chromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007131,biological_process reciprocal meiotic recombination;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0051321,biological_process meiotic cell cycle	NA	kelch domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:20704]
ENSG00000134108	63.83	64.93	63.80	60.10	60.04	62.34	0.0880791389035888	5.66831911014502	0.173515158661732	0.540623409756044	3:5122219-5180912:+	ARL8B	24;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030496,cellular_component midbody;GO:0031902,cellular_component late endosome membrane;GO:0032418,biological_process lysosome localization;GO:0043014,molecular_function alpha-tubulin binding;GO:0048487,molecular_function beta-tubulin binding;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome	NA	ADP ribosylation factor like GTPase 8B [Source:HGNC Symbol%3BAcc:HGNC:25564]
ENSG00000042493	481.32	480.30	463.53	513.49	501.77	501.18	-0.0779166052615023	9.00083603167846	0.173741473924477	0.541192701587085	2:85394747-85418432:-	CAPG	20;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0006461,biological_process protein complex assembly;GO:0008290,cellular_component F-actin capping protein complex;GO:0019904,molecular_function protein domain specific binding;GO:0032403,molecular_function protein complex binding;GO:0042470,cellular_component melanosome;GO:0045296,molecular_function cadherin binding;GO:0051015,molecular_function actin filament binding;GO:0051016,biological_process barbed-end actin filament capping;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome;GO:0072686,cellular_component mitotic spindle;GO:0090543,cellular_component Flemming body	NA	capping actin protein%2C gelsolin like [Source:HGNC Symbol%3BAcc:HGNC:1474]
ENSG00000138074	8.56	8.83	8.11	9.31	9.55	9.23	-0.130907747503368	4.1025143725309	0.173896116687211	0.541451983249752	2:27199586-27212958:-	SLC5A6	17;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006768,biological_process biotin metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0008523,molecular_function sodium-dependent multivitamin transmembrane transporter activity;GO:0012506,cellular_component vesicle membrane;GO:0015293,molecular_function symporter activity;GO:0015878,biological_process biotin transport;GO:0015887,biological_process pantothenate transmembrane transport;GO:0015939,biological_process pantothenate metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031526,cellular_component brush border membrane;GO:0055085,biological_process transmembrane transport	SLC5A6, SMVT; solute carrier family 5 (sodium-dependent multivitamin transporter), member 6; K14386	solute carrier family 5 member 6 [Source:HGNC Symbol%3BAcc:HGNC:11041]
ENSG00000139083	23.25	21.86	24.64	28.25	21.63	27.31	-0.132934935409401	5.14405388301117	0.173924165004863	0.541451983249752	12:11649853-11895402:+	ETV6	25;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007296,biological_process vitellogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019904,molecular_function protein domain specific binding;GO:0022008,biological_process neurogenesis;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:0097152,biological_process mesenchymal cell apoptotic process	NA	ETS variant 6 [Source:HGNC Symbol%3BAcc:HGNC:3495]
ENSG00000170242	20.82	21.66	21.71	22.60	23.17	22.95	-0.0868975478735367	6.51699731314075	0.173984001806465	0.541451983249752	11:11841422-11959323:+	USP47	25;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030307,biological_process positive regulation of cell growth;GO:0034644,biological_process cellular response to UV;GO:0035520,biological_process monoubiquitinated protein deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0071987,molecular_function WD40-repeat domain binding;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	NA	ubiquitin specific peptidase 47 [Source:HGNC Symbol%3BAcc:HGNC:20076]
ENSG00000173928	3.80	3.62	3.43	4.58	3.86	5.02	-0.300818449686493	1.5606282650963	0.173999191265871	0.541451983249752	19:11374684-11376951:+	SWSAP1	12;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000725,biological_process recombinational repair;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016887,molecular_function ATPase activity;GO:0050821,biological_process protein stabilization;GO:0097196,cellular_component Shu complex	NA	SWIM-type zinc finger 7 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26638]
ENSG00000167925	10.56	12.28	9.99	9.50	9.83	10.63	0.133901960613387	4.2525710397516	0.174074372285192	0.541511444516025	17:42188798-42194532:-	GHDC	10;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0034774,cellular_component secretory granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation	NA	GH3 domain containing [Source:HGNC Symbol%3BAcc:HGNC:24438]
ENSG00000206561	2.39	2.18	1.32	1.04	1.73	1.80	0.371694585722076	1.4120263044002	0.174105548623496	0.541511444516025	3:15450132-15521751:-	COLQ	15;GO:0001507,biological_process acetylcholine catabolic process in synaptic cleft;GO:0005515,molecular_function protein binding;GO:0005581,cellular_component collagen trimer;GO:0005605,cellular_component basal lamina;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0008105,biological_process asymmetric protein localization;GO:0008582,biological_process regulation of synaptic growth at neuromuscular junction;GO:0030054,cellular_component cell junction;GO:0031594,cellular_component neuromuscular junction;GO:0042135,biological_process neurotransmitter catabolic process;GO:0043083,cellular_component synaptic cleft;GO:0045202,cellular_component synapse;GO:0071340,biological_process skeletal muscle acetylcholine-gated channel clustering;GO:0090150,biological_process establishment of protein localization to membrane	NA	collagen like tail subunit of asymmetric acetylcholinesterase [Source:HGNC Symbol%3BAcc:HGNC:2226]
ENSG00000104131	68.53	67.60	67.69	71.45	71.25	75.61	-0.0875173397318442	5.83800604794042	0.174275970883253	0.541905718079613	15:44537056-44563029:+	EIF3J	11;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0033290,cellular_component eukaryotic 48S preinitiation complex	EIF3J; translation initiation factor 3 subunit J; K03245	eukaryotic translation initiation factor 3 subunit J [Source:HGNC Symbol%3BAcc:HGNC:3270]
ENSG00000053254	6.84	7.14	6.60	5.39	5.96	7.08	0.164875431664671	3.5714088666996	0.17432308604698	0.541916470598839	14:89124870-89619149:-	FOXN3	14;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0008022,molecular_function protein C-terminus binding;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0097094,biological_process craniofacial suture morphogenesis	NA	forkhead box N3 [Source:HGNC Symbol%3BAcc:HGNC:1928]
ENSG00000143164	76.39	80.72	74.42	69.20	79.02	70.22	0.0952615419389394	7.76187272543514	0.1743952089032	0.541981410809084	1:167935782-168075843:+	DCAF6	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0016567,biological_process protein ubiquitination;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0043687,biological_process post-translational protein modification;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 6 [Source:HGNC Symbol%3BAcc:HGNC:30002]
ENSG00000257704	19.56	17.50	17.97	14.06	14.06	19.64	0.215223108105267	2.90084114116531	0.174453074030507	0.541981410809084	19:47274452-47275707:+	INAFM1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	InaF motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:27406]
ENSG00000186660	5.04	5.31	4.61	4.33	4.57	4.40	0.174317458361378	3.03197943101324	0.174474963150979	0.541981410809084	11:58579110-58621042:+	ZFP91	9;GO:0003676,molecular_function nucleic acid binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0070534,biological_process protein K63-linked ubiquitination	NA	ZFP91 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:14983]
ENSG00000114853	14.72	13.69	12.15	12.90	11.88	12.83	0.12010193025416	4.87533980167393	0.174544263000442	0.542061029928567	3:42653683-42665854:+	ZBTB47	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 47 [Source:HGNC Symbol%3BAcc:HGNC:26955]
ENSG00000131373	14.17	15.07	13.25	16.36	14.39	15.72	-0.122411493962752	4.70126668700449	0.174612357613349	0.54211909907982	3:15560703-15601852:-	HACL1	17;GO:0000287,molecular_function magnesium ion binding;GO:0001561,biological_process fatty acid alpha-oxidation;GO:0003824,molecular_function catalytic activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0016829,molecular_function lyase activity;GO:0016830,molecular_function carbon-carbon lyase activity;GO:0030976,molecular_function thiamine pyrophosphate binding;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0048037,molecular_function cofactor binding;GO:0051259,biological_process protein oligomerization	HACL1; 2-hydroxyacyl-CoA lyase 1 [EC:4.1.-.-]; K12261	2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol%3BAcc:HGNC:17856]
ENSG00000150593	57.47	54.97	58.28	52.63	54.17	55.43	0.0865959917461411	6.30099597221056	0.174650308323548	0.54211909907982	10:110871794-110900006:+	PDCD4	23;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007569,biological_process cell aging;GO:0030509,biological_process BMP signaling pathway;GO:0034393,biological_process positive regulation of smooth muscle cell apoptotic process;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043508,biological_process negative regulation of JUN kinase activity;GO:0045786,biological_process negative regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051246,biological_process regulation of protein metabolic process;GO:0060940,biological_process epithelial to mesenchymal transition involved in cardiac fibroblast development;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1904761,biological_process negative regulation of myofibroblast differentiation;GO:1905064,biological_process negative regulation of vascular smooth muscle cell differentiation;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process	PDCD4; programmed cell death protein 4; K16865	programmed cell death 4 [Source:HGNC Symbol%3BAcc:HGNC:8763]
ENSG00000106617	11.67	11.08	12.83	12.71	9.87	9.72	0.154503092235419	4.48715729732533	0.174850230415566	0.542223502320515	7:151556110-151877125:-	PRKAG2	40;GO:0000166,molecular_function nucleotide binding;GO:0004679,molecular_function AMP-activated protein kinase activity;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005977,biological_process glycogen metabolic process;GO:0006110,biological_process regulation of glycolytic process;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006754,biological_process ATP biosynthetic process;GO:0006853,biological_process carnitine shuttle;GO:0007050,biological_process cell cycle arrest;GO:0008603,molecular_function cAMP-dependent protein kinase regulator activity;GO:0008607,molecular_function phosphorylase kinase regulator activity;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0016126,biological_process sterol biosynthetic process;GO:0016208,molecular_function AMP binding;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019217,biological_process regulation of fatty acid metabolic process;GO:0019901,molecular_function protein kinase binding;GO:0030295,molecular_function protein kinase activator activity;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0032147,biological_process activation of protein kinase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0043531,molecular_function ADP binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046320,biological_process regulation of fatty acid oxidation;GO:0046324,biological_process regulation of glucose import;GO:0050790,biological_process regulation of catalytic activity;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit; K07200	protein kinase AMP-activated non-catalytic subunit gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:9386]
ENSG00000135070	50.88	48.92	52.85	52.52	59.13	55.65	-0.117310687005266	4.5045885469856	0.17486212561539	0.542223502320515	9:86264545-86283102:-	ISCA1	10;GO:0005198,molecular_function structural molecule activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008198,molecular_function ferrous iron binding;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0044281,biological_process small molecule metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0097428,biological_process protein maturation by iron-sulfur cluster transfer	NA	iron-sulfur cluster assembly 1 [Source:HGNC Symbol%3BAcc:HGNC:28660]
ENSG00000204576	20.29	19.99	18.53	20.58	21.78	23.44	-0.153025128946662	3.57126404421659	0.174863664474834	0.542223502320515	6:30556885-30563723:+	PRR3	3;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	proline rich 3 [Source:HGNC Symbol%3BAcc:HGNC:21149]
ENSG00000079332	93.26	105.48	93.43	84.14	96.04	93.72	0.101344572618004	5.93185280787126	0.174895948534716	0.542223502320515	10:70147288-70170523:-	SAR1A	14;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0030127,cellular_component COPII vesicle coat;GO:0070062,cellular_component extracellular exosome;GO:0090110,biological_process cargo loading into COPII-coated vesicle	SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]; K07953	secretion associated Ras related GTPase 1A [Source:HGNC Symbol%3BAcc:HGNC:10534]
ENSG00000008277	2.76	2.90	2.33	3.20	3.48	2.59	-0.204003692289938	3.17618432612075	0.174902352637665	0.542223502320515	7:87934142-88202889:+	ADAM22	17;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007417,biological_process central nervous system development;GO:0008237,molecular_function metallopeptidase activity;GO:0008344,biological_process adult locomotory behavior;GO:0014037,biological_process Schwann cell differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030424,cellular_component axon;GO:0042063,biological_process gliogenesis;GO:0042995,cellular_component cell projection	NA	ADAM metallopeptidase domain 22 [Source:HGNC Symbol%3BAcc:HGNC:201]
ENSG00000181873	1.79	1.16	1.79	1.19	1.07	1.32	0.441163280714229	0.71892776794302	0.174953844395731	0.54224770798607	1:228165814-228182257:+	IBA57	6;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006783,biological_process heme biosynthetic process;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0016740,molecular_function transferase activity	NA	IBA57 homolog%2C iron-sulfur cluster assembly [Source:HGNC Symbol%3BAcc:HGNC:27302]
ENSG00000186575	27.15	32.43	26.07	25.49	28.03	25.95	0.11482874415341	5.64637678674741	0.175231740736087	0.542492327876721	22:29603555-29698598:+	NF2	54;GO:0001707,biological_process mesoderm formation;GO:0001726,cellular_component ruffle;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007398,biological_process ectoderm development;GO:0007420,biological_process brain development;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008156,biological_process negative regulation of DNA replication;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014010,biological_process Schwann cell proliferation;GO:0014013,biological_process regulation of gliogenesis;GO:0016020,cellular_component membrane;GO:0021766,biological_process hippocampus development;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030175,cellular_component filopodium;GO:0030336,biological_process negative regulation of cell migration;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031527,cellular_component filopodium membrane;GO:0031647,biological_process regulation of protein stability;GO:0032154,cellular_component cleavage furrow;GO:0032587,cellular_component ruffle membrane;GO:0035330,biological_process regulation of hippo signaling;GO:0042127,biological_process regulation of cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0044297,cellular_component cell body;GO:0045177,cellular_component apical part of cell;GO:0045216,biological_process cell-cell junction organization;GO:0045597,biological_process positive regulation of cell differentiation;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050767,biological_process regulation of neurogenesis;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051726,biological_process regulation of cell cycle;GO:0070306,biological_process lens fiber cell differentiation;GO:0072091,biological_process regulation of stem cell proliferation;GO:1900180,biological_process regulation of protein localization to nucleus;GO:2000177,biological_process regulation of neural precursor cell proliferation	NF2; merlin; K16684	neurofibromin 2 [Source:HGNC Symbol%3BAcc:HGNC:7773]
ENSG00000171132	2.78	3.17	3.03	3.97	3.25	3.17	-0.205155379015151	2.89740976184986	0.175239332975545	0.542492327876721	2:45651344-46187990:+	PRKCE	71;GO:0000166,molecular_function nucleotide binding;GO:0002281,biological_process macrophage activation involved in immune response;GO:0002376,biological_process immune system process;GO:0003785,molecular_function actin monomer binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0004699,molecular_function calcium-independent protein kinase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007202,biological_process activation of phospholipase C activity;GO:0008047,molecular_function enzyme activator activity;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0030168,biological_process platelet activation;GO:0030546,molecular_function receptor activator activity;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032230,biological_process positive regulation of synaptic transmission, GABAergic;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035276,molecular_function ethanol binding;GO:0035556,biological_process intracellular signal transduction;GO:0035641,biological_process locomotory exploration behavior;GO:0035669,biological_process TRAM-dependent toll-like receptor 4 signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043278,biological_process response to morphine;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050996,biological_process positive regulation of lipid catabolic process;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0051301,biological_process cell division;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070257,biological_process positive regulation of mucus secretion;GO:0071361,biological_process cellular response to ethanol;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0071889,molecular_function 14-3-3 protein binding;GO:0071944,cellular_component cell periphery;GO:0090303,biological_process positive regulation of wound healing;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:2000273,biological_process positive regulation of receptor activity;GO:2000650,biological_process negative regulation of sodium ion transmembrane transporter activity;GO:2001031,biological_process positive regulation of cellular glucuronidation	PRKCD; novel protein kinase C delta type [EC:2.7.11.13]; K06068	protein kinase C epsilon [Source:HGNC Symbol%3BAcc:HGNC:9401]
ENSG00000165195	4.60	6.00	4.54	3.80	5.07	4.17	0.214780291444597	3.04106835603677	0.17524529019841	0.542492327876721	X:15319450-15335580:-	PIGA	14;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0008194,molecular_function UDP-glycosyltransferase activity;GO:0009893,biological_process positive regulation of metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0017176,molecular_function phosphatidylinositol N-acetylglucosaminyltransferase activity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	PIGA, GPI3; phosphatidylinositol N-acetylglucosaminyltransferase subunit A [EC:2.4.1.198]; K03857	phosphatidylinositol glycan anchor biosynthesis class A [Source:HGNC Symbol%3BAcc:HGNC:8957]
ENSG00000198521	1.98	2.26	2.00	1.68	1.94	1.72	0.228233632493197	2.30614934140131	0.175268283079556	0.542492327876721	19:21804948-21852125:-	ZNF43	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 43 [Source:HGNC Symbol%3BAcc:HGNC:13109]
ENSG00000117143	36.62	36.00	36.14	33.56	35.06	34.67	0.0866530068805871	5.79507274142213	0.175307027269238	0.542492327876721	1:162561505-162599842:+	UAP1	13;GO:0003977,molecular_function UDP-N-acetylglucosamine diphosphorylase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006047,biological_process UDP-N-acetylglucosamine metabolic process;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0030246,molecular_function carbohydrate binding;GO:0042802,molecular_function identical protein binding;GO:0070569,molecular_function uridylyltransferase activity	UAP1; UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase [EC:2.7.7.23 2.7.7.83]; K00972	UDP-N-acetylglucosamine pyrophosphorylase 1 [Source:HGNC Symbol%3BAcc:HGNC:12457]
ENSG00000163872	21.11	19.73	19.73	22.44	20.77	21.78	-0.0890104409664019	6.48485194701051	0.175320363384093	0.542492327876721	3:183697817-183812625:+	YEATS2	9;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0017025,molecular_function TBP-class protein binding;GO:0043966,biological_process histone H3 acetylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0072686,cellular_component mitotic spindle	NA	YEATS domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25489]
ENSG00000176834	7.15	8.02	7.22	9.57	7.44	8.25	-0.167812828708243	3.70206073984684	0.175338694871619	0.542492327876721	12:118063592-118136026:-	VSIG10	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	V-set and immunoglobulin domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:26078]
ENSG00000168778	13.38	15.08	14.08	12.41	13.79	13.39	0.110187899578674	4.86230601478795	0.175480985003517	0.542797275566572	12:123671112-123708403:+	TCTN2	11;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0036038,cellular_component MKS complex;GO:0042995,cellular_component cell projection;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	tectonic family member 2 [Source:HGNC Symbol%3BAcc:HGNC:25774]
ENSG00000177989	2.09	2.04	2.27	3.38	3.06	1.92	-0.359027944922231	1.15667662885733	0.1757805178323	0.543452912391686	22:50529709-50532580:-	ODF3B	NA	NA	outer dense fiber of sperm tails 3B [Source:HGNC Symbol%3BAcc:HGNC:34388]
ENSG00000109775	9.15	9.33	10.35	11.07	10.76	10.16	-0.135564291012062	3.97729555095534	0.175813028275232	0.543452912391686	4:185399539-185425985:-	UFSP2	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016790,molecular_function thiolester hydrolase activity;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0071567,molecular_function UFM1 hydrolase activity	NA	UFM1 specific peptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:25640]
ENSG00000152818	12.20	12.49	12.91	11.64	12.35	11.73	0.0858163671014733	7.02765640692155	0.175843825605604	0.543452912391686	6:144285700-144853034:+	UTRN	32;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0003779,molecular_function actin binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006936,biological_process muscle contraction;GO:0007517,biological_process muscle organ development;GO:0007528,biological_process neuromuscular junction development;GO:0008270,molecular_function zinc ion binding;GO:0014894,biological_process response to denervation involved in regulation of muscle adaptation;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016020,cellular_component membrane;GO:0017166,molecular_function vinculin binding;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030426,cellular_component growth cone;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031527,cellular_component filopodium membrane;GO:0031594,cellular_component neuromuscular junction;GO:0042383,cellular_component sarcolemma;GO:0043234,cellular_component protein complex;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome;GO:0070938,cellular_component contractile ring;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	NA	utrophin [Source:HGNC Symbol%3BAcc:HGNC:12635]
ENSG00000100139	10.10	9.39	9.71	11.13	9.83	10.91	-0.112859756001342	4.74609305099512	0.175868069691243	0.543452912391686	22:37905656-37942822:+	MICALL1	26;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0019898,cellular_component extrinsic component of membrane;GO:0031175,biological_process neuron projection development;GO:0031902,cellular_component late endosome membrane;GO:0032456,biological_process endocytic recycling;GO:0032458,biological_process slow endocytic recycling;GO:0036010,biological_process protein localization to endosome;GO:0042802,molecular_function identical protein binding;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0055038,cellular_component recycling endosome membrane;GO:0070300,molecular_function phosphatidic acid binding;GO:0097320,biological_process membrane tubulation;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	MICAL like 1 [Source:HGNC Symbol%3BAcc:HGNC:29804]
ENSG00000104213	1.51	1.02	1.50	0.87	1.21	0.94	0.455307544584162	0.567249883929385	0.176027059186771	0.543697995687605	8:17576432-17644071:+	PDGFRL	7;GO:0004992,molecular_function platelet activating factor receptor activity;GO:0005019,molecular_function platelet-derived growth factor beta-receptor activity;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008150,biological_process biological_process;GO:0035791,biological_process platelet-derived growth factor receptor-beta signaling pathway	NA	platelet derived growth factor receptor like [Source:HGNC Symbol%3BAcc:HGNC:8805]
ENSG00000183688	9.48	10.40	11.93	15.43	12.11	10.74	-0.252679949628288	2.3801989605348	0.176034983055545	0.543697995687605	17:439977-445939:-	RFLNB	12;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0015629,cellular_component actin cytoskeleton;GO:0030036,biological_process actin cytoskeleton organization;GO:0031005,molecular_function filamin binding;GO:0032432,cellular_component actin filament bundle;GO:0048705,biological_process skeletal system morphogenesis;GO:0061181,biological_process regulation of chondrocyte development;GO:0061182,biological_process negative regulation of chondrocyte development;GO:0061572,biological_process actin filament bundle organization;GO:1900158,biological_process negative regulation of bone mineralization involved in bone maturation	NA	refilin B [Source:HGNC Symbol%3BAcc:HGNC:28705]
ENSG00000131089	10.74	9.23	10.25	9.28	9.04	9.76	0.123592406930899	4.52026705727588	0.176205184802011	0.543889232853172	X:63634966-63809274:-	ARHGEF9	9;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0034220,biological_process ion transmembrane transport;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Cdc42 guanine nucleotide exchange factor 9 [Source:HGNC Symbol%3BAcc:HGNC:14561]
ENSG00000131437	6.95	6.52	7.24	7.44	7.12	8.46	-0.138160561405421	4.01190598058838	0.176217019532527	0.543889232853172	5:132692627-132737638:-	KIF3A	65;GO:0000166,molecular_function nucleotide binding;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0001947,biological_process heart looping;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006996,biological_process organelle organization;GO:0007018,biological_process microtubule-based movement;GO:0007224,biological_process smoothened signaling pathway;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008017,molecular_function microtubule binding;GO:0008544,biological_process epidermis development;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010457,biological_process centriole-centriole cohesion;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016939,cellular_component kinesin II complex;GO:0017137,molecular_function Rab GTPase binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019894,molecular_function kinesin binding;GO:0021542,biological_process dentate gyrus development;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021915,biological_process neural tube development;GO:0022008,biological_process neurogenesis;GO:0030030,biological_process cell projection organization;GO:0030507,molecular_function spectrin binding;GO:0030990,cellular_component intraciliary transport particle;GO:0031514,cellular_component motile cilium;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0032403,molecular_function protein complex binding;GO:0034454,biological_process microtubule anchoring at centrosome;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036334,biological_process epidermal stem cell homeostasis;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0044458,biological_process motile cilium assembly;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0060271,biological_process cilium morphogenesis;GO:0061351,biological_process neural precursor cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0097470,cellular_component ribbon synapse;GO:0097542,cellular_component ciliary tip;GO:1904115,cellular_component axon cytoplasm;GO:1905128,biological_process positive regulation of axo-dendritic protein transport;GO:1905515,biological_process non-motile cilium assembly;GO:2000771,biological_process positive regulation of establishment or maintenance of cell polarity regulating cell shape	KIF3A; kinesin family member 3A; K10394	kinesin family member 3A [Source:HGNC Symbol%3BAcc:HGNC:6319]
ENSG00000176371	5.16	4.31	4.99	4.37	4.43	4.24	0.1728346614373	3.2981008018676	0.17626561083147	0.543889232853172	15:84600985-84627796:+	ZSCAN2	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20994]
ENSG00000120727	196.86	204.93	193.18	212.04	218.97	205.97	-0.0879388036179518	6.29299053047721	0.176272164969654	0.543889232853172	5:139341586-139369720:+	PAIP2	10;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006417,biological_process regulation of translation;GO:0007283,biological_process spermatogenesis;GO:0007613,biological_process memory;GO:0017148,biological_process negative regulation of translation;GO:0030371,molecular_function translation repressor activity;GO:0045947,biological_process negative regulation of translational initiation;GO:1900271,biological_process regulation of long-term synaptic potentiation	NA	poly(A) binding protein interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17970]
ENSG00000071894	31.38	32.20	30.88	29.02	30.49	30.34	0.0831185871963609	7.06750680282026	0.176465255553854	0.544281760603139	8:144393228-144409349:-	CPSF1	17;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006379,biological_process mRNA cleavage;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0019899,molecular_function enzyme binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation	CPSF1, CFT1; cleavage and polyadenylation specificity factor subunit 1; K14401	cleavage and polyadenylation specific factor 1 [Source:HGNC Symbol%3BAcc:HGNC:2324]
ENSG00000135316	106.01	110.99	102.30	112.11	117.34	111.85	-0.0850602338315034	7.71647588046976	0.17654337691124	0.544281760603139	6:85607784-85643792:-	SYNCRIP	27;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006417,biological_process regulation of translation;GO:0008143,molecular_function poly(A) binding;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0017148,biological_process negative regulation of translation;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070934,biological_process CRD-mediated mRNA stabilization;GO:0070937,cellular_component CRD-mediated mRNA stability complex;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071204,cellular_component histone pre-mRNA 3'end processing complex;GO:0071346,biological_process cellular response to interferon-gamma;GO:0097452,cellular_component GAIT complex	NA	synaptotagmin binding cytoplasmic RNA interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16918]
ENSG00000174173	30.32	33.91	27.64	26.75	30.24	28.15	0.116266177655902	5.15970622843678	0.176550272922511	0.544281760603139	3:101561861-101566446:+	TRMT10C	17;GO:0000964,biological_process mitochondrial RNA 5'-end processing;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0009019,molecular_function tRNA (guanine-N1-)-methyltransferase activity;GO:0016429,molecular_function tRNA (adenine-N1-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030678,cellular_component mitochondrial ribonuclease P complex;GO:0032259,biological_process methylation;GO:0042645,cellular_component mitochondrial nucleoid;GO:0070131,biological_process positive regulation of mitochondrial translation;GO:0070901,biological_process mitochondrial tRNA methylation;GO:0090646,biological_process mitochondrial tRNA processing	NA	tRNA methyltransferase 10C%2C mitochondrial RNase P subunit [Source:HGNC Symbol%3BAcc:HGNC:26022]
ENSG00000170469	5.20	5.59	5.00	6.00	6.37	5.90	-0.205034686152271	2.6251880991531	0.176597549971682	0.544281760603139	5:139396562-139404088:-	SPATA24	13;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0042803,molecular_function protein homodimerization activity	NA	spermatogenesis associated 24 [Source:HGNC Symbol%3BAcc:HGNC:27322]
ENSG00000091732	34.80	38.03	33.01	37.37	39.67	37.05	-0.0998341615171493	5.86204897968722	0.176618620132881	0.544281760603139	7:130018285-130051451:-	ZC3HC1	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0019901,molecular_function protein kinase binding;GO:0031965,cellular_component nuclear membrane;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	zinc finger C3HC-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29913]
ENSG00000123352	29.95	27.16	31.39	32.01	31.04	32.32	-0.0924666323713156	5.9199632914665	0.176757942350642	0.544575909257514	12:49366583-49527424:+	SPATS2	3;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	spermatogenesis associated serine rich 2 [Source:HGNC Symbol%3BAcc:HGNC:18650]
ENSG00000105618	48.54	48.24	46.82	48.86	53.04	51.88	-0.0873807824657952	6.29769712544982	0.176970151001773	0.545031519932006	19:54115409-54131719:+	PRPF31	23;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005684,cellular_component U2-type spliceosomal complex;GO:0005687,cellular_component U4 snRNP;GO:0005690,cellular_component U4atac snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030621,molecular_function U4 snRNA binding;GO:0030622,molecular_function U4atac snRNA binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0070990,molecular_function snRNP binding;GO:0071011,cellular_component precatalytic spliceosome;GO:0071166,biological_process ribonucleoprotein complex localization;GO:0071339,cellular_component MLL1 complex	PRPF31; U4/U6 small nuclear ribonucleoprotein PRP31; K12844	pre-mRNA processing factor 31 [Source:HGNC Symbol%3BAcc:HGNC:15446]
ENSG00000266714	0.62	0.44	0.69	0.56	0.33	0.55	0.301022194858409	2.42980399853787	0.17699364028405	0.545031519932006	17:75588057-75626501:+	MYO15B	7;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005524,molecular_function ATP binding;GO:0005856,cellular_component cytoskeleton;GO:0005903,cellular_component brush border;GO:0007605,biological_process sensory perception of sound;GO:0016459,cellular_component myosin complex	NA	myosin XVB [Source:HGNC Symbol%3BAcc:HGNC:14083]
ENSG00000100218	1.31	1.31	1.19	0.97	0.79	1.08	0.424846087666718	0.604387795910489	0.177047405496898	0.545061866178819	22:23059414-23145021:-	RSPH14	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	radial spoke head 14 homolog [Source:HGNC Symbol%3BAcc:HGNC:13437]
ENSG00000101773	20.73	19.64	21.66	23.37	20.29	23.45	-0.10004253759309	5.92291605700487	0.177261497634331	0.545448850025063	18:22798260-23026488:+	RBBP8	35;GO:0000014,molecular_function single-stranded DNA endodeoxyribonuclease activity;GO:0000075,biological_process cell cycle checkpoint;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001835,biological_process blastocyst hatching;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0010792,biological_process DNA double-strand break processing involved in repair via single-strand annealing;GO:0016787,molecular_function hydrolase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0032355,biological_process response to estradiol;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	RB binding protein 8%2C endonuclease [Source:HGNC Symbol%3BAcc:HGNC:9891]
ENSG00000100994	140.71	121.32	149.99	164.19	129.70	159.97	-0.127337286299117	8.56009648063627	0.177299922664424	0.545448850025063	20:25248068-25298014:+	PYGB	18;GO:0003824,molecular_function catalytic activity;GO:0004645,molecular_function phosphorylase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005980,biological_process glycogen catabolic process;GO:0008152,biological_process metabolic process;GO:0008184,molecular_function glycogen phosphorylase activity;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0102499,molecular_function SHG alpha-glucan phosphorylase activity	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]; K00688	glycogen phosphorylase B [Source:HGNC Symbol%3BAcc:HGNC:9723]
ENSG00000135913	3.82	3.85	4.37	3.94	2.98	3.82	0.175760775795832	3.52053245903802	0.177340231482237	0.545448850025063	2:218450250-218568361:-	USP37	19;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006275,biological_process regulation of DNA replication;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0051301,biological_process cell division;GO:0071108,biological_process protein K48-linked deubiquitination	NA	ubiquitin specific peptidase 37 [Source:HGNC Symbol%3BAcc:HGNC:20063]
ENSG00000165934	27.85	27.29	27.73	31.44	29.13	28.41	-0.0899756424698172	6.0748758204664	0.177348872851136	0.545448850025063	14:92121936-92172145:+	CPSF2	14;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006379,biological_process mRNA cleavage;GO:0006397,biological_process mRNA processing;GO:0006398,biological_process mRNA 3'-end processing by stem-loop binding and cleavage;GO:0006406,biological_process mRNA export from nucleus;GO:0016020,cellular_component membrane;GO:0031124,biological_process mRNA 3'-end processing	CPSF2, CFT2; cleavage and polyadenylation specificity factor subunit 2; K14402	cleavage and polyadenylation specific factor 2 [Source:HGNC Symbol%3BAcc:HGNC:2325]
ENSG00000128510	1.12	1.89	1.17	1.19	1.32	0.50	0.462656975917502	0.699466862042898	0.17760469738059	0.54603009321822	7:130293133-130324180:+	CPA4	12;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016573,biological_process histone acetylation;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	carboxypeptidase A4 [Source:HGNC Symbol%3BAcc:HGNC:15740]
ENSG00000198064	0.15	0.28	0.35	0.46	0.20	0.49	-0.554061423860947	0.451712674799301	0.177631837537534	0.54603009321822	16:30222936-30254510:-	NPIPB13	3;GO:0005654,cellular_component nucleoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear pore complex interacting protein family%2C member B13 [Source:HGNC Symbol%3BAcc:HGNC:41989]
ENSG00000171421	89.14	89.38	89.56	101.04	89.59	100.81	-0.109775002703875	4.85831215801363	0.177669825707596	0.54603009321822	5:1798385-1801366:-	MRPL36	11;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0016604,cellular_component nuclear body;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36; K02919	mitochondrial ribosomal protein L36 [Source:HGNC Symbol%3BAcc:HGNC:14490]
ENSG00000091164	70.11	71.21	76.04	78.59	77.17	77.05	-0.0867806377562212	6.35372103814189	0.177857834521114	0.546375318699322	18:56597207-56651600:-	TXNL1	16;GO:0000502,cellular_component proteasome complex;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006662,biological_process glycerol ether metabolic process;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015036,molecular_function disulfide oxidoreductase activity;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0034599,biological_process cellular response to oxidative stress;GO:0045454,biological_process cell redox homeostasis;GO:0047134,molecular_function protein-disulfide reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	NA	thioredoxin like 1 [Source:HGNC Symbol%3BAcc:HGNC:12436]
ENSG00000187840	191.13	158.47	180.68	206.22	176.75	194.47	-0.107687238891283	6.03688179360909	0.177980562698695	0.546375318699322	8:38030340-38060365:+	EIF4EBP1	24;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0002192,biological_process IRES-dependent translational initiation;GO:0002931,biological_process response to ischemia;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0008190,molecular_function eukaryotic initiation factor 4E binding;GO:0008286,biological_process insulin receptor signaling pathway;GO:0017148,biological_process negative regulation of translation;GO:0030324,biological_process lung development;GO:0030371,molecular_function translation repressor activity;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031369,molecular_function translation initiation factor binding;GO:0031929,biological_process TOR signaling;GO:0043234,cellular_component protein complex;GO:0045471,biological_process response to ethanol;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045947,biological_process negative regulation of translational initiation;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0071456,biological_process cellular response to hypoxia;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:1990928,biological_process response to amino acid starvation	EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; K07205	eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3288]
ENSG00000143106	131.68	143.55	129.59	143.53	145.81	144.62	-0.0906933467950823	6.66171916082773	0.178017078712661	0.546375318699322	1:109399030-109426427:-	PSMA5	44;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019773,cellular_component proteasome core complex, alpha-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMA5; 20S proteasome subunit alpha 5 [EC:3.4.25.1]; K02729	proteasome subunit alpha 5 [Source:HGNC Symbol%3BAcc:HGNC:9534]
ENSG00000164707	3.12	1.98	2.43	2.31	1.90	2.13	0.277727370512501	2.17947387195341	0.178033218958071	0.546375318699322	7:135681236-135729258:-	SLC13A4	14;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0008272,biological_process sulfate transport;GO:0015293,molecular_function symporter activity;GO:0015382,molecular_function sodium:sulfate symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	solute carrier family 13 member 4 [Source:HGNC Symbol%3BAcc:HGNC:15827]
ENSG00000146143	13.54	14.09	11.65	14.30	15.22	13.79	-0.133455955216822	4.43397584285694	0.178090200833902	0.546375318699322	6:57314804-57646849:+	PRIM2	18;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0003896,molecular_function DNA primase activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005654,cellular_component nucleoplasm;GO:0005658,cellular_component alpha DNA polymerase:primase complex;GO:0006260,biological_process DNA replication;GO:0006269,biological_process DNA replication, synthesis of RNA primer;GO:0006270,biological_process DNA replication initiation;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0071897,biological_process DNA biosynthetic process	PRI2; DNA primase large subunit; K02685	primase (DNA) subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:9370]
ENSG00000101457	34.86	33.27	37.62	40.69	34.06	40.82	-0.114700928233527	5.32478559333347	0.178107627462455	0.546375318699322	20:45791936-45811427:+	DNTTIP1	10;GO:0000118,cellular_component histone deacetylase complex;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031491,molecular_function nucleosome binding;GO:0042803,molecular_function protein homodimerization activity	NA	deoxynucleotidyltransferase terminal interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16160]
ENSG00000061794	64.18	64.59	64.69	67.35	73.04	67.07	-0.0887853778565378	6.03010877345151	0.178110384442935	0.546375318699322	12:27710772-27756295:+	MRPS35	10;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S35 [Source:HGNC Symbol%3BAcc:HGNC:16635]
ENSG00000115648	52.95	54.47	56.08	53.99	47.77	52.79	0.0925556990598669	6.64648268790248	0.178184561085875	0.546375318699322	2:237485427-237555318:+	MLPH	13;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006886,biological_process intracellular protein transport;GO:0017022,molecular_function myosin binding;GO:0017137,molecular_function Rab GTPase binding;GO:0030050,biological_process vesicle transport along actin filament;GO:0030425,cellular_component dendrite;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	melanophilin [Source:HGNC Symbol%3BAcc:HGNC:29643]
ENSG00000139793	25.68	22.08	24.15	21.43	22.91	22.90	0.114005948433779	4.88828765942675	0.178197667763949	0.546375318699322	13:97221433-97394120:+	MBNL2	9;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0043484,biological_process regulation of RNA splicing;GO:0046872,molecular_function metal ion binding	NA	muscleblind like splicing regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:16746]
ENSG00000124251	1.22	0.77	1.78	1.20	2.18	1.94	-0.451014241890917	0.578692885806164	0.178222320584351	0.546375318699322	20:45372562-45407889:-	TP53TG5	5;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0030308,biological_process negative regulation of cell growth;GO:0035556,biological_process intracellular signal transduction	NA	TP53 target 5 [Source:HGNC Symbol%3BAcc:HGNC:15856]
ENSG00000197208	3.85	3.01	4.14	4.98	3.40	4.76	-0.235042771982907	2.77895779324411	0.178647143382213	0.547542466865041	5:132294442-132344206:+	SLC22A4	32;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006641,biological_process triglyceride metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0007589,biological_process body fluid secretion;GO:0008513,molecular_function secondary active organic cation transmembrane transporter activity;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0009437,biological_process carnitine metabolic process;GO:0015226,molecular_function carnitine transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015491,molecular_function cation:cation antiporter activity;GO:0015651,molecular_function quaternary ammonium group transmembrane transporter activity;GO:0015695,biological_process organic cation transport;GO:0015697,biological_process quaternary ammonium group transport;GO:0015711,biological_process organic anion transport;GO:0015879,biological_process carnitine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0030165,molecular_function PDZ domain binding;GO:0034220,biological_process ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0098655,biological_process cation transmembrane transport;GO:1902603,biological_process carnitine transmembrane transport	SLC22A4_5, OCTN; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5; K08202	solute carrier family 22 member 4 [Source:HGNC Symbol%3BAcc:HGNC:10968]
ENSG00000153443	9.04	9.38	10.51	8.64	8.93	8.61	0.157384727079795	3.566797683712	0.17875131266842	0.547550358540239	16:4608882-4615027:-	UBALD1	NA	NA	UBA like domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29576]
ENSG00000135473	18.08	16.99	17.96	17.05	15.94	17.32	0.0893263120671537	5.96156164537917	0.178773721994285	0.547550358540239	12:56316222-56334053:-	PAN2	16;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0031251,cellular_component PAN complex;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]; K12571	PAN2 poly(A) specific ribonuclease subunit [Source:HGNC Symbol%3BAcc:HGNC:20074]
ENSG00000152219	26.71	21.69	26.23	28.89	26.35	27.50	-0.127529390147336	4.37172821636039	0.178785381684298	0.547550358540239	11:30323050-30338227:+	ARL14EP	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	ADP ribosylation factor like GTPase 14 effector protein [Source:HGNC Symbol%3BAcc:HGNC:26798]
ENSG00000169714	275.85	263.61	284.21	314.12	263.09	314.50	-0.102271844929821	7.33336012894465	0.178826162371879	0.547550358540239	3:129169483-129183922:-	CNBP	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	CCHC-type zinc finger nucleic acid binding protein [Source:HGNC Symbol%3BAcc:HGNC:13164]
ENSG00000137955	72.54	69.22	71.18	67.05	59.41	73.45	0.102992076672859	6.15718302860792	0.178917864310842	0.547696041847223	1:75786196-75795079:+	RABGGTB	16;GO:0003824,molecular_function catalytic activity;GO:0004659,molecular_function prenyltransferase activity;GO:0004663,molecular_function Rab geranylgeranyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005968,cellular_component Rab-protein geranylgeranyltransferase complex;GO:0006464,biological_process cellular protein modification process;GO:0007601,biological_process visual perception;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0018344,biological_process protein geranylgeranylation;GO:0042981,biological_process regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	Rab geranylgeranyltransferase beta subunit [Source:HGNC Symbol%3BAcc:HGNC:9796]
ENSG00000163040	13.13	10.32	13.87	11.27	11.07	11.69	0.154945581811023	4.20171570761504	0.179054539662184	0.547979290144646	2:131527674-131533666:+	CCDC74A	NA	NA	coiled-coil domain containing 74A [Source:HGNC Symbol%3BAcc:HGNC:25197]
ENSG00000158480	6.02	6.92	6.13	5.14	6.08	5.81	0.166766042017666	3.24826040767972	0.179136318157912	0.548094433644112	20:49903390-49915508:-	SPATA2	8;GO:0001650,cellular_component fibrillar center;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation	NA	spermatogenesis associated 2 [Source:HGNC Symbol%3BAcc:HGNC:14681]
ENSG00000198908	1.89	1.05	2.20	1.60	1.29	1.20	0.371080043316548	1.43731493533948	0.179186878836136	0.548114028337347	X:102720687-102753540:+	BHLHB9	10;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007611,biological_process learning or memory;GO:0042803,molecular_function protein homodimerization activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0050769,biological_process positive regulation of neurogenesis;GO:0051965,biological_process positive regulation of synapse assembly;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0070062,cellular_component extracellular exosome	NA	basic helix-loop-helix family member b9 [Source:HGNC Symbol%3BAcc:HGNC:29353]
ENSG00000113141	63.45	69.38	61.89	67.51	73.08	68.65	-0.0936501505290297	6.93112834836169	0.179360540700267	0.548406274451196	5:140647057-140662479:+	IK	7;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0006955,biological_process immune response;GO:0007267,biological_process cell-cell signaling;GO:0016607,cellular_component nuclear speck;GO:0042802,molecular_function identical protein binding	NA	IK cytokine%2C down-regulator of HLA II [Source:HGNC Symbol%3BAcc:HGNC:5958]
ENSG00000164338	5.65	5.82	5.12	6.82	5.50	6.53	-0.176598758996898	3.37101587823698	0.17937077856053	0.548406274451196	5:73565442-73583377:+	UTP15	14;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0042254,biological_process ribosome biogenesis;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:2000234,biological_process positive regulation of rRNA processing	UTP15; U3 small nucleolar RNA-associated protein 15; K14549	UTP15%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:25758]
ENSG00000263956	7.24	7.13	7.10	6.91	7.78	9.24	-0.145942665396186	4.33587617217549	0.179589558552334	0.548832376222832	1:148102045-148152322:-	NBPF11	3;GO:0005737,cellular_component cytoplasm;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	NBPF member 11 [Source:HGNC Symbol%3BAcc:HGNC:31993]
ENSG00000107331	44.01	40.14	47.87	42.34	37.82	43.73	0.104128307994369	8.34500427161858	0.179598575059788	0.548832376222832	9:137007226-137028922:-	ABCA2	22;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005815,cellular_component microtubule organizing center;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032383,biological_process regulation of intracellular cholesterol transport;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042632,biological_process cholesterol homeostasis;GO:0043190,cellular_component ATP-binding cassette (ABC) transporter complex;GO:0048545,biological_process response to steroid hormone;GO:0055085,biological_process transmembrane transport	ABCA2; ATP-binding cassette, subfamily A (ABC1), member 2; K05642	ATP binding cassette subfamily A member 2 [Source:HGNC Symbol%3BAcc:HGNC:32]
ENSG00000174332	5.60	5.37	6.82	5.74	4.58	5.60	0.174943172736901	3.76370957995973	0.17977278026898	0.548962936712155	1:53506236-53738106:-	GLIS1	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	GLIS family zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:29525]
ENSG00000103653	28.77	26.19	26.50	31.06	28.76	28.39	-0.0999782043847839	5.26270057951256	0.179773280513677	0.548962936712155	15:74782056-74803198:+	CSK	53;GO:0000166,molecular_function nucleotide binding;GO:0001817,biological_process regulation of cytokine production;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0008022,molecular_function protein C-terminus binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010989,biological_process negative regulation of low-density lipoprotein particle clearance;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019903,molecular_function protein phosphatase binding;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031295,biological_process T cell costimulation;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0033673,biological_process negative regulation of kinase activity;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0034332,biological_process adherens junction organization;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0042997,biological_process negative regulation of Golgi to plasma membrane protein transport;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045779,biological_process negative regulation of bone resorption;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048709,biological_process oligodendrocyte differentiation;GO:0050765,biological_process negative regulation of phagocytosis;GO:0050852,biological_process T cell receptor signaling pathway;GO:0060368,biological_process regulation of Fc receptor mediated stimulatory signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070064,molecular_function proline-rich region binding;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071375,biological_process cellular response to peptide hormone stimulus	CSK; c-src tyrosine kinase [EC:2.7.10.2]; K05728	C-terminal Src kinase [Source:HGNC Symbol%3BAcc:HGNC:2444]
ENSG00000031823	22.89	24.76	22.34	21.01	22.24	22.65	0.0945234431257831	5.53773006814757	0.179773973876976	0.548962936712155	19:5916138-5978142:-	RANBP3	18;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006405,biological_process RNA export from nucleus;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007051,biological_process spindle organization;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046604,biological_process positive regulation of mitotic centrosome separation;GO:0046907,biological_process intracellular transport;GO:0070412,molecular_function R-SMAD binding	RANBP3; Ran-binding protein 3; K15304	RAN binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:9850]
ENSG00000106344	18.17	18.84	17.39	16.74	17.15	17.44	0.0924176033123509	5.39431343663537	0.179948781186969	0.549253006302729	7:128297684-128343908:-	RBM28	7;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing	NOP4, RBM28; nucleolar protein 4; K14573	RNA binding motif protein 28 [Source:HGNC Symbol%3BAcc:HGNC:21863]
ENSG00000184277	20.68	20.96	21.72	19.26	19.51	20.05	0.118978696708067	4.20471262141935	0.180014939482903	0.549253006302729	15:101621443-101652391:-	TM2D3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	TM2 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:24128]
ENSG00000080819	29.29	29.80	28.49	25.42	27.58	29.32	0.099045442370608	5.32269925271248	0.180066222673515	0.549253006302729	3:98521131-98593723:-	CPOX	21;GO:0004109,molecular_function coproporphyrinogen oxidase activity;GO:0005212,molecular_function structural constituent of eye lens;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0010035,biological_process response to inorganic substance;GO:0010039,biological_process response to iron ion;GO:0010288,biological_process response to lead ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0017085,biological_process response to insecticide;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046685,biological_process response to arsenic-containing substance;GO:0051597,biological_process response to methylmercury;GO:0055114,biological_process oxidation-reduction process	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]; K00228	coproporphyrinogen oxidase [Source:HGNC Symbol%3BAcc:HGNC:2321]
ENSG00000149548	1.15	1.52	1.73	1.56	2.00	1.75	-0.261302180469936	2.27102546942333	0.180100680924964	0.549253006302729	11:124954120-125041489:+	CCDC15	1;GO:0005813,cellular_component centrosome	NA	coiled-coil domain containing 15 [Source:HGNC Symbol%3BAcc:HGNC:25798]
ENSG00000196821	85.95	84.77	83.48	78.89	78.90	83.85	0.084490827752538	6.21081567227816	0.180133626540618	0.549253006302729	6:34587287-34696859:-	C6orf106	7;GO:0000407,cellular_component pre-autophagosomal structure;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005776,cellular_component autophagosome;GO:0008150,biological_process biological_process;GO:0016236,biological_process macroautophagy;GO:0043130,molecular_function ubiquitin binding	NA	chromosome 6 open reading frame 106 [Source:HGNC Symbol%3BAcc:HGNC:21215]
ENSG00000119673	18.67	19.79	20.47	17.31	18.58	19.12	0.109010436475547	4.789896680931	0.180208988436295	0.549253006302729	14:73567619-73575658:+	ACOT2	13;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006637,biological_process acyl-CoA metabolic process;GO:0016290,molecular_function palmitoyl-CoA hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0016790,molecular_function thiolester hydrolase activity;GO:0047617,molecular_function acyl-CoA hydrolase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0102991,molecular_function myristoyl-CoA hydrolase activity	ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]; K01068	acyl-CoA thioesterase 2 [Source:HGNC Symbol%3BAcc:HGNC:18431]
ENSG00000149311	10.62	10.73	11.20	10.32	9.98	10.61	0.0861533946175757	6.60457157763561	0.180211774455527	0.549253006302729	11:108222483-108369102:+	ATM	98;GO:0000077,biological_process DNA damage checkpoint;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001541,biological_process ovarian follicle development;GO:0001666,biological_process response to hypoxia;GO:0001756,biological_process somitogenesis;GO:0002331,biological_process pre-B cell allelic exclusion;GO:0002376,biological_process immune system process;GO:0002377,biological_process immunoglobulin production;GO:0003677,molecular_function DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004677,molecular_function DNA-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007140,biological_process male meiosis;GO:0007143,biological_process female meiotic division;GO:0007165,biological_process signal transduction;GO:0007292,biological_process female gamete generation;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0008340,biological_process determination of adult lifespan;GO:0008585,biological_process female gonad development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009791,biological_process post-embryonic development;GO:0010212,biological_process response to ionizing radiation;GO:0010506,biological_process regulation of autophagy;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030889,biological_process negative regulation of B cell proliferation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032210,biological_process regulation of telomere maintenance via telomerase;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032403,molecular_function protein complex binding;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0033151,biological_process V(D)J recombination;GO:0035264,biological_process multicellular organism growth;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0036289,biological_process peptidyl-serine autophosphorylation;GO:0042159,biological_process lipoprotein catabolic process;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045141,biological_process meiotic telomere clustering;GO:0046777,biological_process protein autophosphorylation;GO:0046983,molecular_function protein dimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048538,biological_process thymus development;GO:0048599,biological_process oocyte development;GO:0051402,biological_process neuron apoptotic process;GO:0051726,biological_process regulation of cell cycle;GO:0070192,biological_process chromosome organization involved in meiotic cell cycle;GO:0071044,biological_process histone mRNA catabolic process;GO:0071480,biological_process cellular response to gamma radiation;GO:0071481,biological_process cellular response to X-ray;GO:0071500,biological_process cellular response to nitrosative stress;GO:0072434,biological_process signal transduction involved in mitotic G2 DNA damage checkpoint;GO:0090399,biological_process replicative senescence;GO:0097694,biological_process establishment of RNA localization to telomere;GO:0097695,biological_process establishment of macromolecular complex localization to telomere;GO:1900034,biological_process regulation of cellular response to heat;GO:1901216,biological_process positive regulation of neuron death;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1903626,biological_process positive regulation of DNA catabolic process;GO:1903978,biological_process regulation of microglial cell activation;GO:1904262,biological_process negative regulation of TORC1 signaling;GO:1904354,biological_process negative regulation of telomere capping;GO:1904358,biological_process positive regulation of telomere maintenance via telomere lengthening;GO:1904884,biological_process positive regulation of telomerase catalytic core complex assembly;GO:1905843,biological_process regulation of cellular response to gamma radiation;GO:1990391,cellular_component DNA repair complex;GO:2001022,biological_process positive regulation of response to DNA damage stimulus	ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]; K04728	ATM serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:795]
ENSG00000155016	3.51	3.81	3.34	4.77	4.55	3.27	-0.232754274640245	2.69258893161919	0.180222951314832	0.549253006302729	4:107931368-107953457:+	CYP2U1	18;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008395,molecular_function steroid hydroxylase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016712,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0019825,molecular_function oxygen binding;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070330,molecular_function aromatase activity;GO:0097267,biological_process omega-hydroxylase P450 pathway	CYP2U1; cytochrome P450 family 2 subfamily U polypeptide 1; K07422	cytochrome P450 family 2 subfamily U member 1 [Source:HGNC Symbol%3BAcc:HGNC:20582]
ENSG00000110063	25.22	25.14	23.59	27.40	26.78	26.15	-0.108730876456206	4.70970125655938	0.180402807158536	0.549666186857856	11:126303751-126345749:+	DCPS	21;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003824,molecular_function catalytic activity;GO:0004532,molecular_function exoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016787,molecular_function hydrolase activity;GO:0036245,biological_process cellular response to menadione;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0050072,molecular_function m7G(5')pppN diphosphatase activity;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	DCPS, DCS; m7GpppX diphosphatase [EC:3.6.1.59]; K12584	decapping enzyme%2C scavenger [Source:HGNC Symbol%3BAcc:HGNC:29812]
ENSG00000060237	23.04	21.99	24.59	25.67	23.79	25.17	-0.087825498839065	7.7380207826691	0.180538860749663	0.549868411732034	12:752592-911452:+	WNK1	36;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002028,biological_process regulation of sodium ion transport;GO:0003084,biological_process positive regulation of systemic arterial blood pressure;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006811,biological_process ion transport;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019869,molecular_function chloride channel inhibitor activity;GO:0019870,molecular_function potassium channel inhibitor activity;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0023016,biological_process signal transduction by trans-phosphorylation;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0030295,molecular_function protein kinase activator activity;GO:0032147,biological_process activation of protein kinase activity;GO:0033673,biological_process negative regulation of kinase activity;GO:0035556,biological_process intracellular signal transduction;GO:0046777,biological_process protein autophosphorylation;GO:0048666,biological_process neuron development;GO:0050794,biological_process regulation of cellular process;GO:0071277,biological_process cellular response to calcium ion;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0090188,biological_process negative regulation of pancreatic juice secretion	NA	WNK lysine deficient protein kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:14540]
ENSG00000069998	28.36	29.95	27.75	26.97	25.86	28.07	0.0969228638146134	5.18773579479009	0.180557773803252	0.549868411732034	22:17137510-17165287:-	HDHD5	2;GO:0005739,cellular_component mitochondrion;GO:0046474,biological_process glycerophospholipid biosynthetic process	NA	haloacid dehalogenase like hydrolase domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:1843]
ENSG00000132341	355.99	375.38	335.53	390.92	392.06	361.46	-0.0900779352261934	8.18893188007051	0.180643944344993	0.54999589922845	12:130871878-130877678:+	RAN	59;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0000056,biological_process ribosomal small subunit export from nucleus;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000287,molecular_function magnesium ion binding;GO:0000785,cellular_component chromatin;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0006259,biological_process DNA metabolic process;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007165,biological_process signal transduction;GO:0010586,biological_process miRNA metabolic process;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019003,molecular_function GDP binding;GO:0030496,cellular_component midbody;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031012,cellular_component extracellular matrix;GO:0032092,biological_process positive regulation of protein binding;GO:0035281,biological_process pre-miRNA export from nucleus;GO:0042470,cellular_component melanosome;GO:0042565,cellular_component RNA nuclear export complex;GO:0043234,cellular_component protein complex;GO:0043657,cellular_component host cell;GO:0045296,molecular_function cadherin binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0050681,molecular_function androgen receptor binding;GO:0051301,biological_process cell division;GO:0055037,cellular_component recycling endosome;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070062,cellular_component extracellular exosome;GO:0070883,molecular_function pre-miRNA binding;GO:0075733,biological_process intracellular transport of virus;GO:0090631,molecular_function pre-miRNA transporter activity;GO:1902570,biological_process protein localization to nucleolus	RAN; GTP-binding nuclear protein Ran; K07936	RAN%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9846]
ENSG00000270011	0.34	0.45	0.63	0.61	0.94	0.47	-0.479240984981225	0.438812186996703	0.180728245937828	0.550117635317866	19:9324173-9382617:+	ZNF559-ZNF177	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZNF559-ZNF177 readthrough [Source:HGNC Symbol%3BAcc:HGNC:42964]
ENSG00000088367	17.96	19.89	19.17	18.21	18.18	17.59	0.0889622058037169	6.49640421097841	0.180878704750163	0.55044063791708	20:36091503-36232799:+	EPB41L1	13;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0008092,molecular_function cytoskeletal protein binding;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031032,biological_process actomyosin structure organization;GO:0045296,molecular_function cadherin binding	NA	erythrocyte membrane protein band 4.1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:3378]
ENSG00000187609	3.88	2.85	4.19	3.08	2.95	3.58	0.206938911792117	3.38391571791314	0.180956084933569	0.550541147617744	9:137306895-137423262:-	EXD3	10;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	exonuclease 3'-5' domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:26023]
ENSG00000134440	122.29	106.81	120.43	127.61	119.57	128.54	-0.0912476093661481	7.67787109009899	0.181147925147346	0.550989756151436	18:57600655-57622213:-	NARS	13;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004816,molecular_function asparagine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006421,biological_process asparaginyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity;GO:0070062,cellular_component extracellular exosome	NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]; K01893	asparaginyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:7643]
ENSG00000146109	22.07	22.60	21.20	16.61	22.12	21.03	0.150004662415203	4.10591961246812	0.181213830372791	0.55105518775538	6:26596951-26600744:+	ABT1	17;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472,biological_process endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480,biological_process endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0034462,biological_process small-subunit processome assembly	NA	activator of basal transcription 1 [Source:HGNC Symbol%3BAcc:HGNC:17369]
ENSG00000116016	99.99	85.90	110.77	98.31	80.67	95.24	0.125890116932658	7.95874583956148	0.181339011036603	0.55120558880065	2:46293666-46386703:+	EPAS1	45;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0001892,biological_process embryonic placenta development;GO:0001974,biological_process blood vessel remodeling;GO:0002027,biological_process regulation of heart rate;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006979,biological_process response to oxidative stress;GO:0007005,biological_process mitochondrion organization;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007601,biological_process visual perception;GO:0008134,molecular_function transcription factor binding;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030324,biological_process lung development;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035035,molecular_function histone acetyltransferase binding;GO:0042415,biological_process norepinephrine metabolic process;GO:0043129,biological_process surfactant homeostasis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043619,biological_process regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043687,biological_process post-translational protein modification;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048469,biological_process cell maturation;GO:0048625,biological_process myoblast fate commitment;GO:0055072,biological_process iron ion homeostasis;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0071456,biological_process cellular response to hypoxia	HIF2A, EPAS1; hypoxia-inducible factor 2 alpha; K09095	endothelial PAS domain protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3374]
ENSG00000136813	42.56	39.49	41.19	44.35	41.30	46.28	-0.0860414992562496	8.02422359079407	0.181372430396225	0.55120558880065	9:111360691-111484745:-	KIAA0368	21;GO:0000502,cellular_component proteasome complex;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0016020,cellular_component membrane;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030139,cellular_component endocytic vesicle;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032947,molecular_function protein complex scaffold;GO:0043248,biological_process proteasome assembly	NA	KIAA0368 [Source:HGNC Symbol%3BAcc:HGNC:29020]
ENSG00000187741	8.10	8.39	8.49	9.14	8.72	8.96	-0.0913487955726967	5.52374380973807	0.181422443198489	0.55120558880065	16:89737548-89816657:-	FANCA	17;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006461,biological_process protein complex assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007140,biological_process male meiosis;GO:0008584,biological_process male gonad development;GO:0008585,biological_process female gonad development;GO:0036297,biological_process interstrand cross-link repair;GO:0042127,biological_process regulation of cell proliferation;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0045589,biological_process regulation of regulatory T cell differentiation;GO:0050727,biological_process regulation of inflammatory response;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:2000348,biological_process regulation of CD40 signaling pathway	FANCA; fanconi anemia group A protein; K10888	Fanconi anemia complementation group A [Source:HGNC Symbol%3BAcc:HGNC:3582]
ENSG00000166840	1.31	1.24	1.50	2.15	1.12	2.15	-0.406674357003668	0.905760253155526	0.181440911611976	0.55120558880065	11:58905397-59043527:+	GLYATL1	5;GO:0005739,cellular_component mitochondrion;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0047946,molecular_function glutamine N-acyltransferase activity;GO:0047961,molecular_function glycine N-acyltransferase activity	NA	glycine-N-acyltransferase like 1 [Source:HGNC Symbol%3BAcc:HGNC:30519]
ENSG00000179168	0.36	0.93	0.83	0.38	0.58	0.54	0.466225140475858	0.385147472480908	0.181503454070937	0.551260674182173	19:38384264-38388082:-	GGN	6;GO:0005515,molecular_function protein binding;GO:0006302,biological_process double-strand break repair;GO:0007275,biological_process multicellular organism development;GO:0007276,biological_process gamete generation;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation	NA	gametogenetin [Source:HGNC Symbol%3BAcc:HGNC:18869]
ENSG00000107371	28.34	24.67	25.96	23.23	23.35	26.51	0.12694855116159	4.3994208345685	0.181910040990477	0.552272714660964	9:37766977-37801437:-	EXOSC3	26;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000467,biological_process exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0035327,cellular_component transcriptionally active chromatin;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045006,biological_process DNA deamination;GO:0045190,biological_process isotype switching;GO:0045830,biological_process positive regulation of isotype switching;GO:0071034,biological_process CUT catabolic process;GO:0071035,biological_process nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038,biological_process nuclear polyadenylation-dependent tRNA catabolic process;GO:0071049,biological_process nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription;GO:0071051,biological_process polyadenylation-dependent snoRNA 3'-end processing	RRP40, EXOSC3; exosome complex component RRP40; K03681	exosome component 3 [Source:HGNC Symbol%3BAcc:HGNC:17944]
ENSG00000120075	7.70	6.99	8.30	6.87	7.14	6.10	0.215232382037476	2.57383507186074	0.181925652964528	0.552272714660964	17:48591256-48593961:-	HOXB5	19;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045446,biological_process endothelial cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development	NA	homeobox B5 [Source:HGNC Symbol%3BAcc:HGNC:5116]
ENSG00000102893	28.33	28.33	29.30	25.15	29.42	26.57	0.0953634101159345	6.65843811627143	0.1819836682755	0.552313758998479	16:47461122-47701523:+	PHKB	13;GO:0003824,molecular_function catalytic activity;GO:0004689,molecular_function phosphorylase kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005964,cellular_component phosphorylase kinase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005980,biological_process glycogen catabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane	PHKA_B; phosphorylase kinase alpha/beta subunit; K07190	phosphorylase kinase regulatory subunit beta [Source:HGNC Symbol%3BAcc:HGNC:8927]
ENSG00000086475	53.09	57.29	55.89	58.13	61.20	58.72	-0.0887852920467006	6.08027450951298	0.182075750074792	0.552458148540307	10:13317423-13348298:-	SEPHS1	16;GO:0000166,molecular_function nucleotide binding;GO:0004756,molecular_function selenide, water dikinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0016020,cellular_component membrane;GO:0016260,biological_process selenocysteine biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031965,cellular_component nuclear membrane;GO:0042802,molecular_function identical protein binding	selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]; K01008	selenophosphate synthetase 1 [Source:HGNC Symbol%3BAcc:HGNC:19685]
ENSG00000131848	1.28	1.54	0.69	1.01	0.87	0.71	0.432070552891265	0.709938756641165	0.182140320476283	0.552519012236583	19:56219669-56368383:-	ZSCAN5A	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 5A [Source:HGNC Symbol%3BAcc:HGNC:23710]
ENSG00000184939	12.66	10.89	12.17	13.56	12.29	13.22	-0.111806637288942	4.76300007815618	0.182234652376397	0.552670105044763	16:68530089-68576072:+	ZFP90	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043392,biological_process negative regulation of DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP90 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:23329]
ENSG00000181031	11.77	9.56	10.04	12.63	10.96	12.00	-0.162462874457246	3.49233270389087	0.182283686401224	0.552683780971761	17:212388-386254:-	RPH3AL	23;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0017157,biological_process regulation of exocytosis;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0030141,cellular_component secretory granule;GO:0030274,molecular_function LIM domain binding;GO:0030658,cellular_component transport vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042493,biological_process response to drug;GO:0042593,biological_process glucose homeostasis;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0050714,biological_process positive regulation of protein secretion	NA	rabphilin 3A like (without C2 domains) [Source:HGNC Symbol%3BAcc:HGNC:10296]
ENSG00000127863	2.60	4.27	2.42	3.46	5.06	3.20	-0.341449292000266	2.19186035369649	0.182351196270111	0.552717351275517	13:23570369-23676104:+	TNFRSF19	13;GO:0001942,biological_process hair follicle development;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007254,biological_process JNK cascade;GO:0009888,biological_process tissue development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330,biological_process positive regulation of JNK cascade	TNFRSF19, TROY; tumor necrosis factor receptor superfamily member 19; K05155	TNF receptor superfamily member 19 [Source:HGNC Symbol%3BAcc:HGNC:11915]
ENSG00000118407	0.10	0.13	0.20	0.29	0.08	0.31	-0.647360723063209	-0.25891545662307	0.182383813004472	0.552717351275517	6:75291858-75493738:-	FILIP1	5;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0015629,cellular_component actin cytoskeleton	NA	filamin A interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21015]
ENSG00000149657	35.10	35.19	32.17	34.45	31.49	30.35	0.100274775301731	5.60881848539136	0.182490584004014	0.552769806050337	20:62122460-62135378:+	LSM14B	4;GO:0003723,molecular_function RNA binding;GO:0006417,biological_process regulation of translation;GO:0007275,biological_process multicellular organism development;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	LSM family member 14B [Source:HGNC Symbol%3BAcc:HGNC:15887]
ENSG00000104047	17.75	19.46	18.37	16.93	17.15	17.42	0.116270544971913	4.31698069977698	0.182538674417533	0.552769806050337	15:49620979-49656232:+	DTWD1	NA	NA	DTW domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30926]
ENSG00000183814	4.12	4.78	4.26	4.41	5.49	5.06	-0.181420596560733	3.1917320263281	0.182562998816914	0.552769806050337	1:226231148-226309869:-	LIN9	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0017053,cellular_component transcriptional repressor complex;GO:0051726,biological_process regulation of cell cycle;GO:0071897,biological_process DNA biosynthetic process	NA	lin-9 DREAM MuvB core complex component [Source:HGNC Symbol%3BAcc:HGNC:30830]
ENSG00000178719	193.78	197.10	212.24	193.20	196.72	182.83	0.0865338572286617	7.97262602579685	0.182579247950244	0.552769806050337	8:143990057-143993415:+	GRINA	7;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0044325,molecular_function ion channel binding;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	NA	glutamate ionotropic receptor NMDA type subunit associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4589]
ENSG00000163312	5.02	4.92	5.82	5.53	5.79	6.13	-0.131739155448563	4.20858793236581	0.182778713557393	0.553098137388646	4:83407342-83455856:-	HELQ	13;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016787,molecular_function hydrolase activity	NA	helicase%2C POLQ like [Source:HGNC Symbol%3BAcc:HGNC:18536]
ENSG00000140993	6.13	5.11	6.03	4.68	5.39	5.38	0.182101543675936	3.19587362547357	0.182787657700993	0.553098137388646	16:3298831-3305729:-	TIGD7	4;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	tigger transposable element derived 7 [Source:HGNC Symbol%3BAcc:HGNC:18331]
ENSG00000165271	9.98	11.61	11.02	10.95	10.46	8.62	0.128504490099255	5.18078685104341	0.182874798321991	0.553098137388646	9:33461440-33473930:-	NOL6	12;GO:0000794,cellular_component condensed nuclear chromosome;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006364,biological_process rRNA processing;GO:0006409,biological_process tRNA export from nucleus;GO:0032040,cellular_component small-subunit processome;GO:0032545,cellular_component CURI complex;GO:0034456,cellular_component UTP-C complex	UTP22, NOL6; U3 small nucleolar RNA-associated protein 22; K14544	nucleolar protein 6 [Source:HGNC Symbol%3BAcc:HGNC:19910]
ENSG00000167232	8.07	7.78	8.63	8.23	6.69	7.78	0.121991028021274	4.8660001870274	0.18288286991915	0.553098137388646	19:23304990-23395560:-	ZNF91	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070895,biological_process negative regulation of transposon integration	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 91 [Source:HGNC Symbol%3BAcc:HGNC:13166]
ENSG00000185669	1.29	2.84	1.01	1.45	1.30	0.72	0.528575998961355	0.441384307988247	0.182910485296092	0.553098137388646	16:88677681-88686493:-	SNAI3	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005507,molecular_function copper ion binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	snail family transcriptional repressor 3 [Source:HGNC Symbol%3BAcc:HGNC:18411]
ENSG00000083290	3.98	3.16	3.35	3.60	3.94	4.35	-0.161472179237387	3.63337099944505	0.183148841365938	0.553370384160555	17:19770828-19867936:-	ULK2	22;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0006914,biological_process autophagy;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0042594,biological_process response to starvation;GO:0046777,biological_process protein autophosphorylation;GO:0048671,biological_process negative regulation of collateral sprouting;GO:0048675,biological_process axon extension;GO:0075044,biological_process autophagy of host cells involved in interaction with symbiont	ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]; K08269	unc-51 like autophagy activating kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:13480]
ENSG00000188859	1.17	0.37	1.88	0.48	0.29	1.35	0.721333968646402	-0.154293249154573	0.183154133579224	0.553370384160555	1:166057425-166166969:-	FAM78B	NA	NA	family with sequence similarity 78 member B [Source:HGNC Symbol%3BAcc:HGNC:13495]
ENSG00000140675	19.71	17.96	19.16	17.41	17.45	18.72	0.0996674763144217	5.22181125444132	0.183190644943792	0.553370384160555	16:31483001-31490860:+	SLC5A2	17;GO:0005215,molecular_function transporter activity;GO:0005362,molecular_function low-affinity glucose:sodium symporter activity;GO:0005412,molecular_function glucose:sodium symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0008643,biological_process carbohydrate transport;GO:0008645,biological_process hexose transport;GO:0015293,molecular_function symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 5 member 2 [Source:HGNC Symbol%3BAcc:HGNC:11037]
ENSG00000182372	2.76	3.36	2.73	2.92	2.07	2.13	0.310621450946541	1.51247425561667	0.183255685390611	0.553370384160555	8:1755777-1801711:+	CLN8	15;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006644,biological_process phospholipid metabolic process;GO:0006672,biological_process ceramide metabolic process;GO:0006869,biological_process lipid transport;GO:0007399,biological_process nervous system development;GO:0008203,biological_process cholesterol metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030163,biological_process protein catabolic process;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0045861,biological_process negative regulation of proteolysis;GO:0046513,biological_process ceramide biosynthetic process	NA	CLN8%2C transmembrane ER and ERGIC protein [Source:HGNC Symbol%3BAcc:HGNC:2079]
ENSG00000153187	262.98	254.06	254.15	268.17	272.85	277.97	-0.0749023520399954	9.45389904097448	0.18325627677866	0.553370384160555	1:244840637-244864560:-	HNRNPU	37;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001047,molecular_function core promoter binding;GO:0001649,biological_process osteoblast differentiation;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016070,biological_process RNA metabolic process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032922,biological_process circadian regulation of gene expression;GO:0034046,molecular_function poly(G) binding;GO:0035326,molecular_function enhancer binding;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0048511,biological_process rhythmic process;GO:0055013,biological_process cardiac muscle cell development;GO:0070034,molecular_function telomerase RNA binding;GO:0070934,biological_process CRD-mediated mRNA stabilization;GO:0070937,cellular_component CRD-mediated mRNA stability complex;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:2000373,biological_process positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	HNRNPU; heterogeneous nuclear ribonucleoprotein U; K12888	heterogeneous nuclear ribonucleoprotein U [Source:HGNC Symbol%3BAcc:HGNC:5048]
ENSG00000130810	2.38	2.02	2.23	2.47	2.40	3.21	-0.27061350476954	1.87553424126055	0.183303499883807	0.553370384160555	19:10106288-10111634:+	PPAN	6;GO:0000027,biological_process ribosomal large subunit assembly;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0019843,molecular_function rRNA binding;GO:0030687,cellular_component preribosome, large subunit precursor	NA	peter pan homolog (Drosophila) [Source:HGNC Symbol%3BAcc:HGNC:9227]
ENSG00000124508	18.37	17.98	18.14	19.25	21.31	18.63	-0.105927965405844	5.00053678890039	0.183315193020546	0.553370384160555	6:26383095-26394874:+	BTN2A2	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031324,biological_process negative regulation of cellular metabolic process;GO:0046007,biological_process negative regulation of activated T cell proliferation;GO:0050710,biological_process negative regulation of cytokine secretion;GO:0070062,cellular_component extracellular exosome	NA	butyrophilin subfamily 2 member A2 [Source:HGNC Symbol%3BAcc:HGNC:1137]
ENSG00000198276	18.51	17.95	19.21	20.76	19.71	19.66	-0.0967560198561753	5.10930313235247	0.183357157017028	0.553370384160555	20:63939828-63956415:-	UCKL1	18;GO:0000166,molecular_function nucleotide binding;GO:0004849,molecular_function uridine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006206,biological_process pyrimidine nucleobase metabolic process;GO:0006222,biological_process UMP biosynthetic process;GO:0008152,biological_process metabolic process;GO:0009116,biological_process nucleoside metabolic process;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0044206,biological_process UMP salvage;GO:0044211,biological_process CTP salvage	udk, UCK; uridine kinase [EC:2.7.1.48]; K00876	uridine-cytidine kinase 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:15938]
ENSG00000164379	7.48	8.14	7.18	7.68	9.54	8.67	-0.176788305714398	3.31598665873204	0.183664694029457	0.5541637936285	6:1312439-1314748:+	FOXQ1	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030154,biological_process cell differentiation;GO:0031069,biological_process hair follicle morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding	NA	forkhead box Q1 [Source:HGNC Symbol%3BAcc:HGNC:20951]
ENSG00000197622	129.63	108.87	121.74	106.78	113.60	115.71	0.118107592604369	4.79291306114156	0.183885024596517	0.554276132477854	1:151050970-151070325:-	CDC42SE1	10;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005198,molecular_function structural molecule activity;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006909,biological_process phagocytosis;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0034260,biological_process negative regulation of GTPase activity	NA	CDC42 small effector 1 [Source:HGNC Symbol%3BAcc:HGNC:17719]
ENSG00000244274	6.03	5.31	8.04	5.87	5.65	5.17	0.240321680862718	2.63906474101412	0.183896935523286	0.554276132477854	20:45406056-45410610:+	DBNDD2	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031175,biological_process neuron projection development	NA	dysbindin domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:15881]
ENSG00000177675	3.97	3.68	3.65	4.18	4.56	3.80	-0.134220723688226	4.15598394226742	0.183899666763343	0.554276132477854	12:7346684-7479897:-	CD163L1	6;GO:0005044,molecular_function scavenger receptor activity;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006898,biological_process receptor-mediated endocytosis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CD163 molecule like 1 [Source:HGNC Symbol%3BAcc:HGNC:30375]
ENSG00000172354	229.81	229.73	232.20	218.38	227.75	213.78	0.0798428197635486	7.84602030635943	0.183945136250645	0.554276132477854	7:100673530-100679174:+	GNB2	24;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005246,molecular_function calcium channel regulator activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0031982,cellular_component vesicle;GO:0032403,molecular_function protein complex binding;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0044297,cellular_component cell body;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051020,molecular_function GTPase binding;GO:0065009,biological_process regulation of molecular function;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus	NA	G protein subunit beta 2 [Source:HGNC Symbol%3BAcc:HGNC:4398]
ENSG00000125618	117.74	128.53	116.32	127.54	125.95	134.68	-0.0879054856898556	7.46062867037576	0.183986433360392	0.554276132477854	2:113215996-113278950:-	PAX8	54;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001655,biological_process urogenital system development;GO:0001656,biological_process metanephros development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001822,biological_process kidney development;GO:0001823,biological_process mesonephros development;GO:0003337,biological_process mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004996,molecular_function thyroid-stimulating hormone receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006790,biological_process sulfur compound metabolic process;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0030154,biological_process cell differentiation;GO:0030878,biological_process thyroid gland development;GO:0038194,biological_process thyroid-stimulating hormone signaling pathway;GO:0039003,biological_process pronephric field specification;GO:0042472,biological_process inner ear morphogenesis;GO:0042981,biological_process regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048793,biological_process pronephros development;GO:0071371,biological_process cellular response to gonadotropin stimulus;GO:0071599,biological_process otic vesicle development;GO:0072050,biological_process S-shaped body morphogenesis;GO:0072073,biological_process kidney epithelium development;GO:0072108,biological_process positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072164,biological_process mesonephric tubule development;GO:0072207,biological_process metanephric epithelium development;GO:0072221,biological_process metanephric distal convoluted tubule development;GO:0072278,biological_process metanephric comma-shaped body morphogenesis;GO:0072284,biological_process metanephric S-shaped body morphogenesis;GO:0072289,biological_process metanephric nephron tubule formation;GO:0072305,biological_process negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis;GO:0072307,biological_process regulation of metanephric nephron tubule epithelial cell differentiation;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:1900212,biological_process negative regulation of mesenchymal cell apoptotic process involved in metanephros development;GO:1900215,biological_process negative regulation of apoptotic process involved in metanephric collecting duct development;GO:1900218,biological_process negative regulation of apoptotic process involved in metanephric nephron tubule development;GO:2000594,biological_process positive regulation of metanephric DCT cell differentiation;GO:2000611,biological_process positive regulation of thyroid hormone generation;GO:2000612,biological_process regulation of thyroid-stimulating hormone secretion	PAX8; paired box protein 8; K09293	paired box 8 [Source:HGNC Symbol%3BAcc:HGNC:8622]
ENSG00000109390	132.89	142.09	139.78	150.73	136.38	164.38	-0.114081931932133	5.04880863018167	0.183998814633975	0.554276132477854	4:139266879-139302551:-	NDUFC1	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NA	NADH:ubiquinone oxidoreductase subunit C1 [Source:HGNC Symbol%3BAcc:HGNC:7705]
ENSG00000183323	3.64	3.43	3.07	3.52	2.52	2.57	0.248901133422721	2.30170738384875	0.184014496249193	0.554276132477854	5:69280174-69332809:-	CCDC125	2;GO:0005737,cellular_component cytoplasm;GO:2000145,biological_process regulation of cell motility	NA	coiled-coil domain containing 125 [Source:HGNC Symbol%3BAcc:HGNC:28924]
ENSG00000196510	16.73	16.37	18.05	18.99	18.05	18.38	-0.101249848401945	5.00659819196477	0.18414096326279	0.554522507758614	12:110372899-110403730:-	ANAPC7	15;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0019903,molecular_function protein phosphatase binding;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC7; anaphase-promoting complex subunit 7; K03354	anaphase promoting complex subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:17380]
ENSG00000114315	4.04	2.50	4.12	5.08	2.71	6.28	-0.374877101960347	1.87866832602018	0.184353858750559	0.55502897130019	3:194136144-194138732:+	HES1	103;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0001889,biological_process liver development;GO:0003143,biological_process embryonic heart tube morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003266,biological_process regulation of secondary heart field cardioblast proliferation;GO:0003281,biological_process ventricular septum development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0007155,biological_process cell adhesion;GO:0007219,biological_process Notch signaling pathway;GO:0007224,biological_process smoothened signaling pathway;GO:0007262,biological_process STAT protein import into nucleus;GO:0007389,biological_process pattern specification process;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016477,biological_process cell migration;GO:0021537,biological_process telencephalon development;GO:0021555,biological_process midbrain-hindbrain boundary morphogenesis;GO:0021557,biological_process oculomotor nerve development;GO:0021558,biological_process trochlear nerve development;GO:0021575,biological_process hindbrain morphogenesis;GO:0021861,biological_process forebrain radial glial cell differentiation;GO:0021915,biological_process neural tube development;GO:0021983,biological_process pituitary gland development;GO:0021984,biological_process adenohypophysis development;GO:0030324,biological_process lung development;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030901,biological_process midbrain development;GO:0031016,biological_process pancreas development;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035909,biological_process aorta morphogenesis;GO:0035910,biological_process ascending aorta morphogenesis;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042491,biological_process auditory receptor cell differentiation;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042668,biological_process auditory receptor cell fate determination;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043388,biological_process positive regulation of DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045165,biological_process cell fate commitment;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045607,biological_process regulation of auditory receptor cell differentiation;GO:0045608,biological_process negative regulation of auditory receptor cell differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045977,biological_process positive regulation of mitotic cell cycle, embryonic;GO:0046331,biological_process lateral inhibition;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0046983,molecular_function protein dimerization activity;GO:0048469,biological_process cell maturation;GO:0048505,biological_process regulation of timing of cell differentiation;GO:0048538,biological_process thymus development;GO:0048667,biological_process cell morphogenesis involved in neuron differentiation;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0048715,biological_process negative regulation of oligodendrocyte differentiation;GO:0048844,biological_process artery morphogenesis;GO:0050678,biological_process regulation of epithelial cell proliferation;GO:0050767,biological_process regulation of neurogenesis;GO:0051087,molecular_function chaperone binding;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0060164,biological_process regulation of timing of neuron differentiation;GO:0060253,biological_process negative regulation of glial cell proliferation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060675,biological_process ureteric bud morphogenesis;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0061009,biological_process common bile duct development;GO:0061106,biological_process negative regulation of stomach neuroendocrine cell differentiation;GO:0061309,biological_process cardiac neural crest cell development involved in outflow tract morphogenesis;GO:0061626,biological_process pharyngeal arch artery morphogenesis;GO:0071820,molecular_function N-box binding;GO:0072012,biological_process glomerulus vasculature development;GO:0072049,biological_process comma-shaped body morphogenesis;GO:0072050,biological_process S-shaped body morphogenesis;GO:0072141,biological_process renal interstitial fibroblast development;GO:0072282,biological_process metanephric nephron tubule morphogenesis;GO:0090102,biological_process cochlea development;GO:0090162,biological_process establishment of epithelial cell polarity;GO:0097084,biological_process vascular smooth muscle cell development;GO:0097150,biological_process neuronal stem cell population maintenance;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2000227,biological_process negative regulation of pancreatic A cell differentiation;GO:2000737,biological_process negative regulation of stem cell differentiation;GO:2000974,biological_process negative regulation of pro-B cell differentiation;GO:2000978,biological_process negative regulation of forebrain neuron differentiation;GO:2000981,biological_process negative regulation of inner ear receptor cell differentiation	HES1; hairy and enhancer of split 1; K06054	hes family bHLH transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:5192]
ENSG00000120217	3.25	3.41	4.57	3.01	2.18	3.80	0.329423141942771	1.62763155452778	0.184467325423894	0.555235914279049	9:5450502-5470566:+	CD274	23;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0031295,biological_process T cell costimulation;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032693,biological_process negative regulation of interleukin-10 production;GO:0034097,biological_process response to cytokine;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0046007,biological_process negative regulation of activated T cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:1901998,biological_process toxin transport;GO:1903556,biological_process negative regulation of tumor necrosis factor superfamily cytokine production;GO:1905404,biological_process positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process;GO:2001181,biological_process positive regulation of interleukin-10 secretion	PDL1, CD274; programmed cell death 1 ligand 1; K06745	CD274 molecule [Source:HGNC Symbol%3BAcc:HGNC:17635]
ENSG00000005469	7.95	8.21	6.62	6.58	7.60	6.33	0.159369083678544	3.8217145652429	0.184550589137989	0.555351869810875	7:87345680-87399795:+	CROT	18;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0008458,molecular_function carnitine O-octanoyltransferase activity;GO:0009437,biological_process carnitine metabolic process;GO:0015908,biological_process fatty acid transport;GO:0015936,biological_process coenzyme A metabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051791,biological_process medium-chain fatty acid metabolic process	CROT; carnitine O-octanoyltransferase [EC:2.3.1.137]; K05940	carnitine O-octanoyltransferase [Source:HGNC Symbol%3BAcc:HGNC:2366]
ENSG00000067221	4.38	5.93	4.45	6.32	5.27	5.59	-0.22525798577991	2.71287290079523	0.184704818161654	0.555681267048135	15:73978922-73994622:-	STOML1	6;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	stomatin like 1 [Source:HGNC Symbol%3BAcc:HGNC:14560]
ENSG00000005206	16.40	16.27	17.81	14.97	15.81	16.52	0.106729900778313	4.92706654971298	0.18478503492444	0.555787893994929	19:2328614-2354806:+	SPPL2B	27;GO:0000139,cellular_component Golgi membrane;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0008233,molecular_function peptidase activity;GO:0010008,cellular_component endosome membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0033619,biological_process membrane protein proteolysis;GO:0042500,molecular_function aspartic endopeptidase activity, intramembrane cleaving;GO:0042803,molecular_function protein homodimerization activity;GO:0050776,biological_process regulation of immune response;GO:0071458,cellular_component integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane	NA	signal peptide peptidase like 2B [Source:HGNC Symbol%3BAcc:HGNC:30627]
ENSG00000171877	14.08	14.99	13.58	16.37	14.60	15.34	-0.111025354360063	4.91286804611206	0.184973088433976	0.556218737095674	15:43870760-44195252:-	FRMD5	14;GO:0005178,molecular_function integrin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005856,cellular_component cytoskeleton;GO:0005912,cellular_component adherens junction;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030334,biological_process regulation of cell migration;GO:0031032,biological_process actomyosin structure organization;GO:0045785,biological_process positive regulation of cell adhesion;GO:2000146,biological_process negative regulation of cell motility	NA	FERM domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:28214]
ENSG00000001084	36.98	33.90	37.70	33.50	32.35	36.75	0.0953873405290122	6.1474677644624	0.185355958048329	0.557165066028404	6:53497340-53616970:-	GCLC	48;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004357,molecular_function glutamate-cysteine ligase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006534,biological_process cysteine metabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006749,biological_process glutathione metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0006979,biological_process response to oxidative stress;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009408,biological_process response to heat;GO:0009410,biological_process response to xenobiotic stimulus;GO:0009725,biological_process response to hormone;GO:0014823,biological_process response to activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016595,molecular_function glutamate binding;GO:0016874,molecular_function ligase activity;GO:0017109,cellular_component glutamate-cysteine ligase complex;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043531,molecular_function ADP binding;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0044752,biological_process response to human chorionic gonadotropin;GO:0045454,biological_process cell redox homeostasis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046685,biological_process response to arsenic-containing substance;GO:0046686,biological_process response to cadmium ion;GO:0046982,molecular_function protein heterodimerization activity;GO:0050662,molecular_function coenzyme binding;GO:0050880,biological_process regulation of blood vessel size;GO:0051409,biological_process response to nitrosative stress;GO:0051900,biological_process regulation of mitochondrial depolarization;GO:0070555,biological_process response to interleukin-1;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0097069,biological_process cellular response to thyroxine stimulus;GO:2000490,biological_process negative regulation of hepatic stellate cell activation;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]; K11204	glutamate-cysteine ligase catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:4311]
ENSG00000111335	0.44	0.55	0.33	0.17	0.20	0.50	0.564239466702419	-0.0544729769269106	0.185377565672868	0.557165066028404	12:112978394-113011723:+	OAS2	29;GO:0000166,molecular_function nucleotide binding;GO:0001730,molecular_function 2'-5'-oligoadenylate synthetase activity;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006401,biological_process RNA catabolic process;GO:0006486,biological_process protein glycosylation;GO:0006955,biological_process immune response;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0018377,biological_process protein myristoylation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway	OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]; K14216	2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol%3BAcc:HGNC:8087]
ENSG00000270629	3.34	3.01	3.26	3.00	3.05	2.99	0.105315765132307	4.92452927609175	0.185436548749712	0.557207426683653	1:148531384-148679751:-	NBPF14	3;GO:0005509,molecular_function calcium ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	NBPF member 14 [Source:HGNC Symbol%3BAcc:HGNC:25232]
ENSG00000143207	20.55	19.74	19.28	19.26	16.75	19.89	0.10330208795362	5.47968271811255	0.185571996420467	0.557275973133049	1:175944830-176207493:-	RFWD2	19;GO:0000139,cellular_component Golgi membrane;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010212,biological_process response to ionizing radiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	RFWD2, COP1; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]; K10143	ring finger and WD repeat domain 2 [Source:HGNC Symbol%3BAcc:HGNC:17440]
ENSG00000128245	94.37	102.55	89.10	103.74	107.37	97.13	-0.0982210655842323	6.52922746454131	0.185575600342076	0.557275973133049	22:31944460-31957603:+	YWHAH	31;GO:0002028,biological_process regulation of sodium ion transport;GO:0003779,molecular_function actin binding;GO:0004497,molecular_function monooxygenase activity;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006713,biological_process glucocorticoid catabolic process;GO:0006886,biological_process intracellular protein transport;GO:0014704,cellular_component intercalated disc;GO:0017080,molecular_function sodium channel regulator activity;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0021762,biological_process substantia nigra development;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0044325,molecular_function ion channel binding;GO:0045664,biological_process regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0048167,biological_process regulation of synaptic plasticity;GO:0050774,biological_process negative regulation of dendrite morphogenesis;GO:0055114,biological_process oxidation-reduction process;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0086010,biological_process membrane depolarization during action potential;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	YWHAG_H; 14-3-3 protein gamma/eta; K16198	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [Source:HGNC Symbol%3BAcc:HGNC:12853]
ENSG00000197712	53.02	59.41	51.86	48.81	54.29	51.58	0.0963272576891749	6.49025885388143	0.185594044383471	0.557275973133049	4:38867676-38945739:+	FAM114A1	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol	NA	family with sequence similarity 114 member A1 [Source:HGNC Symbol%3BAcc:HGNC:25087]
ENSG00000170248	62.22	66.16	59.85	57.99	61.44	59.32	0.0853382986932714	7.35043685809595	0.185665789086409	0.557356575557338	3:33798351-33869707:+	PDCD6IP	45;GO:0000281,biological_process mitotic cytokinesis;GO:0000915,biological_process actomyosin contractile ring assembly;GO:0000920,biological_process cell separation after cytokinesis;GO:0001772,cellular_component immunological synapse;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005923,cellular_component bicellular tight junction;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0010824,biological_process regulation of centrosome duplication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019058,biological_process viral life cycle;GO:0030054,cellular_component cell junction;GO:0030496,cellular_component midbody;GO:0031871,molecular_function proteinase activated receptor binding;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042470,cellular_component melanosome;GO:0042641,cellular_component actomyosin;GO:0042803,molecular_function protein homodimerization activity;GO:0043209,cellular_component myelin sheath;GO:0045199,biological_process maintenance of epithelial cell apical/basal polarity;GO:0046755,biological_process viral budding;GO:0046983,molecular_function protein dimerization activity;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051260,biological_process protein homooligomerization;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly;GO:0070971,cellular_component endoplasmic reticulum exit site;GO:0090543,cellular_component Flemming body;GO:0090559,biological_process regulation of membrane permeability;GO:0090611,biological_process ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903551,biological_process regulation of extracellular exosome assembly;GO:1903553,biological_process positive regulation of extracellular exosome assembly;GO:1903561,cellular_component extracellular vesicle	PDCD6IP, ALIX, RIM20; programmed cell death 6-interacting protein; K12200	programmed cell death 6 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:8766]
ENSG00000186866	33.03	33.59	33.22	29.35	33.54	31.48	0.0925070797205897	5.74580148041207	0.185784960730874	0.557579477164491	21:45263927-45287898:-	POFUT2	16;GO:0001707,biological_process mesoderm formation;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006004,biological_process fucose metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008417,molecular_function fucosyltransferase activity;GO:0010468,biological_process regulation of gene expression;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0036065,biological_process fucosylation;GO:0036066,biological_process protein O-linked fucosylation;GO:0046922,molecular_function peptide-O-fucosyltransferase activity;GO:0051046,biological_process regulation of secretion	POFUT; peptide-O-fucosyltransferase [EC:2.4.1.221]; K03691	protein O-fucosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:14683]
ENSG00000197930	137.57	126.94	130.76	126.60	116.49	131.82	0.0885485932817228	7.55146617782907	0.185936895698544	0.557900576820409	14:52639915-52695900:-	ERO1A	31;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0006464,biological_process cellular protein modification process;GO:0006915,biological_process apoptotic process;GO:0009266,biological_process response to temperature stimulus;GO:0010260,biological_process organ senescence;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015036,molecular_function disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0019471,biological_process 4-hydroxyproline metabolic process;GO:0022417,biological_process protein maturation by protein folding;GO:0030198,biological_process extracellular matrix organization;GO:0030425,cellular_component dendrite;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0034599,biological_process cellular response to oxidative stress;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045454,biological_process cell redox homeostasis;GO:0050873,biological_process brown fat cell differentiation;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0055114,biological_process oxidation-reduction process;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071456,biological_process cellular response to hypoxia	ERO1L; ERO1-like protein alpha [EC:1.8.4.-]; K10950	endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol%3BAcc:HGNC:13280]
ENSG00000188559	3.69	3.66	3.76	4.42	3.89	3.86	-0.117259746778861	4.50232069693547	0.186007310343462	0.557976980012903	20:20389551-20712488:-	RALGAPA2	10;GO:0005096,molecular_function GTPase activator activity;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0090630,biological_process activation of GTPase activity	NA	Ral GTPase activating protein catalytic alpha subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:16207]
ENSG00000143578	9.38	10.79	9.41	7.95	9.69	8.93	0.157817903302382	3.50886280723445	0.186121066304711	0.558183328349933	1:153967533-153974363:+	CREB3L4	22;GO:0000139,cellular_component Golgi membrane;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006986,biological_process response to unfolded protein;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031965,cellular_component nuclear membrane;GO:0035497,molecular_function cAMP response element binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	CREB3; cyclic AMP-responsive element-binding protein 3; K09048	cAMP responsive element binding protein 3 like 4 [Source:HGNC Symbol%3BAcc:HGNC:18854]
ENSG00000127774	72.34	75.29	67.80	82.59	84.12	70.11	-0.126209690305948	4.6448749023854	0.18616727287843	0.558187043053128	17:3668814-3669668:+	EMC6	9;GO:0000045,biological_process autophagosome assembly;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0072546,cellular_component ER membrane protein complex;GO:0097631,cellular_component integral component of omegasome membrane	NA	ER membrane protein complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:28430]
ENSG00000196924	357.16	361.85	349.10	339.01	349.68	333.75	0.0747574192756213	11.4383227727947	0.186219590890911	0.558209075520135	X:154348523-154374638:-	FLNA	80;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0002576,biological_process platelet degranulation;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007195,biological_process adenylate cyclase-inhibiting dopamine receptor signaling pathway;GO:0008134,molecular_function transcription factor binding;GO:0015459,molecular_function potassium channel regulator activity;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016479,biological_process negative regulation of transcription from RNA polymerase I promoter;GO:0017048,molecular_function Rho GTPase binding;GO:0017160,molecular_function Ral GTPase binding;GO:0019900,molecular_function kinase binding;GO:0021943,biological_process formation of radial glial scaffolds;GO:0021987,biological_process cerebral cortex development;GO:0030018,cellular_component Z disc;GO:0030030,biological_process cell projection organization;GO:0030168,biological_process platelet activation;GO:0030334,biological_process regulation of cell migration;GO:0030863,cellular_component cortical cytoskeleton;GO:0031012,cellular_component extracellular matrix;GO:0031267,molecular_function small GTPase binding;GO:0031523,cellular_component Myb complex;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031852,molecular_function mu-type opioid receptor binding;GO:0031941,cellular_component filamentous actin;GO:0032403,molecular_function protein complex binding;GO:0034329,biological_process cell junction assembly;GO:0034394,biological_process protein localization to cell surface;GO:0034988,molecular_function Fc-gamma receptor I complex binding;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043113,biological_process receptor clustering;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043198,cellular_component dendritic shaft;GO:0043234,cellular_component protein complex;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0044319,biological_process wound healing, spreading of cells;GO:0044325,molecular_function ion channel binding;GO:0045184,biological_process establishment of protein localization;GO:0045296,molecular_function cadherin binding;GO:0046332,molecular_function SMAD binding;GO:0048365,molecular_function Rac GTPase binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0051015,molecular_function actin filament binding;GO:0051020,molecular_function GTPase binding;GO:0051220,biological_process cytoplasmic sequestering of protein;GO:0051764,biological_process actin crosslink formation;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0072659,biological_process protein localization to plasma membrane;GO:0090307,biological_process mitotic spindle assembly;GO:0097440,cellular_component apical dendrite;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1901381,biological_process positive regulation of potassium ion transmembrane transport;GO:1905000,biological_process regulation of membrane repolarization during atrial cardiac muscle cell action potential;GO:1905031,biological_process regulation of membrane repolarization during cardiac muscle cell action potential;GO:2000179,biological_process positive regulation of neural precursor cell proliferation;GO:2001046,biological_process positive regulation of integrin-mediated signaling pathway;GO:2001224,biological_process positive regulation of neuron migration	FLNA; filamin; K04437	filamin A [Source:HGNC Symbol%3BAcc:HGNC:3754]
ENSG00000204271	9.29	10.12	9.68	11.08	10.18	11.17	-0.150961357381436	3.50931270670906	0.18653458779359	0.558825737885477	X:56818297-56995827:-	SPIN3	3;GO:0007276,biological_process gamete generation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	spindlin family member 3 [Source:HGNC Symbol%3BAcc:HGNC:27272]
ENSG00000104964	131.42	126.85	113.68	111.06	114.35	125.05	0.0969880815977558	6.7591482912654	0.186536910795314	0.558825737885477	19:3052909-3063107:-	AES	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001501,biological_process skeletal system development;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009887,biological_process organ morphogenesis;GO:0010629,biological_process negative regulation of gene expression;GO:0016055,biological_process Wnt signaling pathway;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032091,biological_process negative regulation of protein binding;GO:0040008,biological_process regulation of growth;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0060761,biological_process negative regulation of response to cytokine stimulus;GO:0070555,biological_process response to interleukin-1;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000210,biological_process positive regulation of anoikis	NA	amino-terminal enhancer of split [Source:HGNC Symbol%3BAcc:HGNC:307]
ENSG00000136026	48.49	48.37	43.52	44.27	44.97	43.74	0.089030585641402	6.4054167701191	0.186560368790576	0.558825737885477	12:106237876-106304279:-	CKAP4	23;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0031012,cellular_component extracellular matrix;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0042599,cellular_component lamellar body;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	CKAP4, CLIMP63; cytoskeleton-associated protein 4; K13999	cytoskeleton associated protein 4 [Source:HGNC Symbol%3BAcc:HGNC:16991]
ENSG00000175756	73.58	71.71	64.11	77.88	75.46	72.91	-0.100719787625114	5.44376576039864	0.186674497660945	0.559032699509122	1:1373729-1375495:-	AURKAIP1	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0006397,biological_process mRNA processing;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045839,biological_process negative regulation of mitotic nuclear division;GO:0045862,biological_process positive regulation of proteolysis;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	aurora kinase A interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24114]
ENSG00000152705	0.71	1.36	1.17	1.69	1.40	1.30	-0.451810018421416	0.731250294284043	0.186747735937322	0.559117136080554	5:134967905-135011707:+	CATSPER3	30;GO:0001669,cellular_component acrosomal vesicle;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006816,biological_process calcium ion transport;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0032570,biological_process response to progesterone;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035036,biological_process sperm-egg recognition;GO:0036128,cellular_component CatSper complex;GO:0042995,cellular_component cell projection;GO:0048240,biological_process sperm capacitation;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086010,biological_process membrane depolarization during action potential	NA	cation channel sperm associated 3 [Source:HGNC Symbol%3BAcc:HGNC:20819]
ENSG00000168806	5.70	5.85	4.79	4.95	5.12	4.58	0.165106432157132	3.4256893042253	0.186945952448101	0.559517732027431	15:43323648-43330605:-	LCMT2	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008175,molecular_function tRNA methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0031591,biological_process wybutosine biosynthetic process;GO:0032259,biological_process methylation	NA	leucine carboxyl methyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:17558]
ENSG00000179111	3.49	1.89	2.70	2.96	1.18	1.99	0.433608310246646	0.886123691356794	0.186995430124868	0.559517732027431	17:8120589-8124092:-	HES7	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001501,biological_process skeletal system development;GO:0001756,biological_process somitogenesis;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007498,biological_process mesoderm development;GO:0008134,molecular_function transcription factor binding;GO:0014807,biological_process regulation of somitogenesis;GO:0036342,biological_process post-anal tail morphogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process	HES2_6_7; hairy and enhancer of split 2/6/7; K09087	hes family bHLH transcription factor 7 [Source:HGNC Symbol%3BAcc:HGNC:15977]
ENSG00000120697	18.67	17.21	19.84	17.79	17.32	16.35	0.133012971792454	4.13255931189868	0.187016762280014	0.559517732027431	13:36949774-37000261:-	ALG5	12;GO:0004576,molecular_function oligosaccharyl transferase activity;GO:0004581,molecular_function dolichyl-phosphate beta-glucosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0007368,biological_process determination of left/right symmetry;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine	ALG5; dolichyl-phosphate beta-glucosyltransferase [EC:2.4.1.117]; K00729	ALG5%2C dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:20266]
ENSG00000020181	0.36	0.41	0.35	0.22	0.22	0.39	0.434897786831336	0.58017549526239	0.187104355364968	0.559644906782012	8:37784190-37844896:+	ADGRA2	22;GO:0001525,biological_process angiogenesis;GO:0002040,biological_process sprouting angiogenesis;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007417,biological_process central nervous system development;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030175,cellular_component filopodium;GO:0042995,cellular_component cell projection;GO:0043542,biological_process endothelial cell migration;GO:0045765,biological_process regulation of angiogenesis;GO:0050920,biological_process regulation of chemotaxis;GO:0090210,biological_process regulation of establishment of blood-brain barrier;GO:1900747,biological_process negative regulation of vascular endothelial growth factor signaling pathway	NA	adhesion G protein-coupled receptor A2 [Source:HGNC Symbol%3BAcc:HGNC:17849]
ENSG00000185787	227.47	224.16	218.09	212.44	215.19	212.83	0.0761379187824851	8.12055778520655	0.187258411536941	0.559894338884512	15:78810486-78898133:+	MORF4L1	23;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006342,biological_process chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008283,biological_process cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016580,cellular_component Sin3 complex;GO:0016607,cellular_component nuclear speck;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0047485,molecular_function protein N-terminus binding	NA	mortality factor 4 like 1 [Source:HGNC Symbol%3BAcc:HGNC:16989]
ENSG00000186907	22.35	26.49	24.17	22.96	22.57	22.65	0.104459797875764	5.07140547116078	0.18730692900357	0.559894338884512	11:57460548-57477534:+	RTN4RL2	25;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004872,molecular_function receptor activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006501,biological_process C-terminal protein lipidation;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0022038,biological_process corpus callosum development;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031103,biological_process axon regeneration;GO:0031225,cellular_component anchored component of membrane;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043204,cellular_component perikaryon;GO:0045121,cellular_component membrane raft;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046658,cellular_component anchored component of plasma membrane;GO:0070062,cellular_component extracellular exosome	NA	reticulon 4 receptor like 2 [Source:HGNC Symbol%3BAcc:HGNC:23053]
ENSG00000152527	2.23	2.07	1.90	2.12	2.61	2.33	-0.171476222687672	3.35823640654373	0.187386388423701	0.559894338884512	2:43637272-43767987:+	PLEKHH2	11;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030835,biological_process negative regulation of actin filament depolymerization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection	NA	pleckstrin homology%2C MyTH4 and FERM domain containing H2 [Source:HGNC Symbol%3BAcc:HGNC:30506]
ENSG00000119599	19.44	19.78	20.95	21.31	21.79	21.90	-0.0992799619919748	4.96995505067977	0.18740520852861	0.559894338884512	14:72926331-72959703:+	DCAF4	9;GO:0003723,molecular_function RNA binding;GO:0005654,cellular_component nucleoplasm;GO:0005682,cellular_component U5 snRNP;GO:0008380,biological_process RNA splicing;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 4 [Source:HGNC Symbol%3BAcc:HGNC:20229]
ENSG00000177508	29.13	26.46	25.18	25.52	26.48	23.78	0.105801210124222	5.35665929536342	0.187413274636683	0.559894338884512	16:54283303-54286763:-	IRX3	14;GO:0001656,biological_process metanephros development;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007498,biological_process mesoderm development;GO:0030424,cellular_component axon;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0072047,biological_process proximal/distal pattern formation involved in nephron development;GO:0072086,biological_process specification of loop of Henle identity	NA	iroquois homeobox 3 [Source:HGNC Symbol%3BAcc:HGNC:14360]
ENSG00000110429	19.88	21.29	20.28	18.73	20.04	18.86	0.101675663274455	4.90081316502515	0.187654756012503	0.56039707341391	11:33740938-33774543:-	FBXO3	7;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0016567,biological_process protein ubiquitination	NA	F-box protein 3 [Source:HGNC Symbol%3BAcc:HGNC:13582]
ENSG00000100577	59.77	54.24	51.82	59.17	60.70	59.31	-0.0979782936539134	5.33013557960184	0.187681020390738	0.56039707341391	14:77320883-77331597:+	GSTZ1	19;GO:0003824,molecular_function catalytic activity;GO:0004364,molecular_function glutathione transferase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0006572,biological_process tyrosine catabolic process;GO:0006749,biological_process glutathione metabolic process;GO:0008152,biological_process metabolic process;GO:0009072,biological_process aromatic amino acid family metabolic process;GO:0016034,molecular_function maleylacetoacetate isomerase activity;GO:0016740,molecular_function transferase activity;GO:0016853,molecular_function isomerase activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	maiA, GSTZ1; maleylacetoacetate isomerase [EC:5.2.1.2]; K01800	glutathione S-transferase zeta 1 [Source:HGNC Symbol%3BAcc:HGNC:4643]
ENSG00000083067	0.16	0.13	0.19	0.28	0.13	0.28	-0.476787402596334	0.368763308273405	0.187755507011891	0.56039707341391	9:70529062-71446904:-	TRPM3	20;GO:0005216,molecular_function ion channel activity;GO:0005227,molecular_function calcium activated cation channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0007216,biological_process G-protein coupled glutamate receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016048,biological_process detection of temperature stimulus;GO:0034220,biological_process ion transmembrane transport;GO:0050951,biological_process sensory perception of temperature stimulus;GO:0051262,biological_process protein tetramerization;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071482,biological_process cellular response to light stimulus;GO:0098655,biological_process cation transmembrane transport	NA	transient receptor potential cation channel subfamily M member 3 [Source:HGNC Symbol%3BAcc:HGNC:17992]
ENSG00000002549	46.36	46.28	44.86	46.12	51.24	49.90	-0.0876610471879896	6.21142107554196	0.18776213875199	0.56039707341391	4:17577191-17607972:+	LAP3	18;GO:0004177,molecular_function aminopeptidase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0019538,biological_process protein metabolic process;GO:0030145,molecular_function manganese ion binding;GO:0030496,cellular_component midbody;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	LAP3; cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5]; K11142	leucine aminopeptidase 3 [Source:HGNC Symbol%3BAcc:HGNC:18449]
ENSG00000105991	3.79	6.75	5.20	4.25	4.60	4.13	0.269681736192804	2.28994147041016	0.187830756425049	0.560467110457725	7:27092992-27095996:-	HOXA1	26;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007605,biological_process sensory perception of sound;GO:0007634,biological_process optokinetic behavior;GO:0009653,biological_process anatomical structure morphogenesis;GO:0021599,biological_process abducens nerve formation;GO:0042473,biological_process outer ear morphogenesis;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048702,biological_process embryonic neurocranium morphogenesis;GO:0048839,biological_process inner ear development;GO:0048844,biological_process artery morphogenesis;GO:0050795,biological_process regulation of behavior;GO:0050890,biological_process cognition;GO:0050905,biological_process neuromuscular process;GO:0060840,biological_process artery development;GO:0060876,biological_process semicircular canal formation;GO:0090102,biological_process cochlea development;GO:0090103,biological_process cochlea morphogenesis	NA	homeobox A1 [Source:HGNC Symbol%3BAcc:HGNC:5099]
ENSG00000145740	14.42	16.09	15.24	12.70	16.06	13.61	0.120114511893992	5.12915739834694	0.188256356262756	0.561465726867287	5:69093645-69131069:+	SLC30A5	24;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006824,biological_process cobalt ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0008270,molecular_function zinc ion binding;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0010043,biological_process response to zinc ion;GO:0010155,biological_process regulation of proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030141,cellular_component secretory granule;GO:0030667,cellular_component secretory granule membrane;GO:0055085,biological_process transmembrane transport;GO:0061088,biological_process regulation of sequestering of zinc ion;GO:0071577,biological_process zinc II ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	solute carrier family 30 member 5 [Source:HGNC Symbol%3BAcc:HGNC:19089]
ENSG00000175874	3.57	2.75	3.05	2.24	2.62	2.75	0.323563200341637	1.39027509306068	0.18827808538588	0.561465726867287	2:101345550-101387595:-	CREG2	4;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0048037,molecular_function cofactor binding	NA	cellular repressor of E1A stimulated genes 2 [Source:HGNC Symbol%3BAcc:HGNC:14272]
ENSG00000139626	1.84	3.08	2.28	2.22	1.85	1.91	0.255405200144425	2.43264347159516	0.188301121481392	0.561465726867287	12:53191317-53207307:-	ITGB7	26;GO:0001618,molecular_function virus receptor activity;GO:0003366,biological_process cell-matrix adhesion involved in ameboidal cell migration;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0034669,cellular_component integrin alpha4-beta7 complex;GO:0043113,biological_process receptor clustering;GO:0043235,cellular_component receptor complex;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0050901,biological_process leukocyte tethering or rolling;GO:0070062,cellular_component extracellular exosome;GO:0072678,biological_process T cell migration	ITGB7; integrin beta 7; K06590	integrin subunit beta 7 [Source:HGNC Symbol%3BAcc:HGNC:6162]
ENSG00000152443	4.53	5.95	5.52	5.66	6.36	6.17	-0.184770272546936	3.18624707449528	0.188484735252632	0.561570386277995	19:57746795-57758159:+	ZNF776	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 776 [Source:HGNC Symbol%3BAcc:HGNC:26765]
ENSG00000173141	36.47	49.34	41.61	41.11	34.45	37.69	0.169864119618338	3.62645801862622	0.188517779769909	0.561570386277995	13:21176644-21179084:+	MRPL57	10;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L57 [Source:HGNC Symbol%3BAcc:HGNC:14514]
ENSG00000179195	71.80	69.57	70.41	77.93	76.52	72.38	-0.0860387794996936	5.84415195676952	0.188520085824151	0.561570386277995	12:123971844-124015439:+	ZNF664	9;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 664 [Source:HGNC Symbol%3BAcc:HGNC:25406]
ENSG00000136068	109.15	102.95	105.65	113.11	110.51	113.76	-0.074595719391982	9.79043914340458	0.188588543962094	0.561570386277995	3:58008399-58172251:+	FLNB	30;GO:0001725,cellular_component stress fiber;GO:0003334,biological_process keratinocyte development;GO:0003382,biological_process epithelial cell morphogenesis;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0007519,biological_process skeletal muscle tissue development;GO:0015629,cellular_component actin cytoskeleton;GO:0016021,cellular_component integral component of membrane;GO:0030018,cellular_component Z disc;GO:0030036,biological_process actin cytoskeleton organization;GO:0030154,biological_process cell differentiation;GO:0031012,cellular_component extracellular matrix;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	FLNA; filamin; K04437	filamin B [Source:HGNC Symbol%3BAcc:HGNC:3755]
ENSG00000164163	29.40	25.26	28.26	25.12	24.69	28.10	0.105039429036371	5.59735162600165	0.188692761056451	0.561570386277995	4:145097931-145129179:+	ABCE1	19;GO:0000054,biological_process ribosomal subunit export from nucleus;GO:0000166,molecular_function nucleotide binding;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006413,biological_process translational initiation;GO:0006415,biological_process translational termination;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016887,molecular_function ATPase activity;GO:0043024,molecular_function ribosomal small subunit binding;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0060698,molecular_function endoribonuclease inhibitor activity;GO:0060702,biological_process negative regulation of endoribonuclease activity	NA	ATP binding cassette subfamily E member 1 [Source:HGNC Symbol%3BAcc:HGNC:69]
ENSG00000187391	1.03	0.58	0.87	0.71	0.73	0.64	0.294735195744979	2.01741523492422	0.188696803088092	0.561570386277995	7:78017056-79453574:-	MAGI2	44;GO:0002092,biological_process positive regulation of receptor internalization;GO:0003402,biological_process planar cell polarity pathway involved in axis elongation;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019902,molecular_function phosphatase binding;GO:0030054,cellular_component cell junction;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030336,biological_process negative regulation of cell migration;GO:0030425,cellular_component dendrite;GO:0031697,molecular_function beta-1 adrenergic receptor binding;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0032926,biological_process negative regulation of activin receptor signaling pathway;GO:0032947,molecular_function protein complex scaffold;GO:0036057,cellular_component slit diaphragm;GO:0038180,biological_process nerve growth factor signaling pathway;GO:0043005,cellular_component neuron projection;GO:0043113,biological_process receptor clustering;GO:0043234,cellular_component protein complex;GO:0045202,cellular_component synapse;GO:0046332,molecular_function SMAD binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051291,biological_process protein heterooligomerization;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060395,biological_process SMAD protein signal transduction;GO:0070699,molecular_function type II activin receptor binding;GO:0071850,biological_process mitotic cell cycle arrest;GO:0072015,biological_process glomerular visceral epithelial cell development;GO:0097118,biological_process neuroligin clustering involved in postsynaptic membrane assembly;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000809,biological_process positive regulation of synaptic vesicle clustering	AIP1; atrophin-1 interacting protein 1; K05629	membrane associated guanylate kinase%2C WW and PDZ domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18957]
ENSG00000162642	56.67	46.78	55.72	50.39	49.85	48.31	0.119085129167493	4.88574981180798	0.188702181828615	0.561570386277995	1:85249952-85259672:-	C1orf52	2;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus	NA	chromosome 1 open reading frame 52 [Source:HGNC Symbol%3BAcc:HGNC:24871]
ENSG00000244067	1.38	2.30	1.66	2.02	2.85	2.22	-0.427797429022766	0.60467542561828	0.188725914467709	0.561570386277995	6:52750088-52763569:-	GSTA2	11;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0030855,biological_process epithelial cell differentiation;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:4627]
ENSG00000139842	24.42	23.53	23.15	25.50	26.78	24.07	-0.0897357200150869	5.83269764877924	0.188785058455971	0.561570386277995	13:113208192-113267108:+	CUL4A	38;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0001701,biological_process in utero embryonic development;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0030097,biological_process hemopoiesis;GO:0030853,biological_process negative regulation of granulocyte differentiation;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0051246,biological_process regulation of protein metabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:2000001,biological_process regulation of DNA damage checkpoint;GO:2000819,biological_process regulation of nucleotide-excision repair	CUL4; cullin 4; K10609	cullin 4A [Source:HGNC Symbol%3BAcc:HGNC:2554]
ENSG00000011347	0.92	0.51	0.78	0.50	0.47	0.68	0.447480206812719	0.591116477468083	0.188790530585804	0.561570386277995	11:61515312-61581148:-	SYT7	51;GO:0000149,molecular_function SNARE binding;GO:0001778,biological_process plasma membrane repair;GO:0001786,molecular_function phosphatidylserine binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0006909,biological_process phagocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0014059,biological_process regulation of dopamine secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030276,molecular_function clathrin binding;GO:0030425,cellular_component dendrite;GO:0030658,cellular_component transport vesicle membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031045,cellular_component dense core granule;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032009,cellular_component early phagosome;GO:0036465,biological_process synaptic vesicle recycling;GO:0042734,cellular_component presynaptic membrane;GO:0043025,cellular_component neuronal cell body;GO:0043195,cellular_component terminal bouton;GO:0043679,cellular_component axon terminus;GO:0045202,cellular_component synapse;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0046850,biological_process regulation of bone remodeling;GO:0046872,molecular_function metal ion binding;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0050764,biological_process regulation of phagocytosis;GO:0050796,biological_process regulation of insulin secretion;GO:0070062,cellular_component extracellular exosome;GO:0070092,biological_process regulation of glucagon secretion;GO:0090119,biological_process vesicle-mediated cholesterol transport;GO:0090385,biological_process phagosome-lysosome fusion;GO:1990926,biological_process short-term synaptic potentiation;GO:1990927,biological_process calcium ion regulated lysosome exocytosis	NA	synaptotagmin 7 [Source:HGNC Symbol%3BAcc:HGNC:11514]
ENSG00000105854	280.80	303.88	275.96	267.51	279.18	272.67	0.0821346370831134	8.39490799965936	0.188846345640591	0.561570386277995	7:95404862-95435329:-	PON2	17;GO:0004064,molecular_function arylesterase activity;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005886,cellular_component plasma membrane;GO:0006979,biological_process response to oxidative stress;GO:0009636,biological_process response to toxic substance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019372,biological_process lipoxygenase pathway;GO:0019439,biological_process aromatic compound catabolic process;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0102007,molecular_function acyl-L-homoserine-lactone lactonohydrolase activity	NA	paraoxonase 2 [Source:HGNC Symbol%3BAcc:HGNC:9205]
ENSG00000168917	16.06	13.14	17.45	14.30	12.15	15.76	0.162292459828066	4.21229397583835	0.188879107605787	0.561570386277995	3:136818646-136855892:+	SLC35G2	5;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member G2 [Source:HGNC Symbol%3BAcc:HGNC:28480]
ENSG00000066739	9.63	10.70	10.80	9.60	10.34	9.44	0.094089961499861	5.97743611895604	0.188937781458649	0.561592947575193	14:96279201-96363870:-	ATG2B	9;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0005811,cellular_component lipid particle;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0019898,cellular_component extrinsic component of membrane;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0044804,biological_process nucleophagy	NA	autophagy related 2B [Source:HGNC Symbol%3BAcc:HGNC:20187]
ENSG00000152404	6.13	6.36	6.07	5.04	5.66	6.29	0.134936115982772	4.01544427094841	0.189029619780794	0.561592947575193	11:107326344-107457844:-	CWF19L2	2;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding	NA	CWF19 like 2%2C cell cycle control (S. pombe) [Source:HGNC Symbol%3BAcc:HGNC:26508]
ENSG00000111877	2.66	3.04	2.85	3.25	3.49	2.91	-0.166764383753039	3.40916911678651	0.18907680685308	0.561592947575193	6:118813441-118935162:-	MCM9	13;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006270,biological_process DNA replication initiation;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007276,biological_process gamete generation;GO:0007292,biological_process female gamete generation;GO:0016787,molecular_function hydrolase activity;GO:0097362,cellular_component MCM8-MCM9 complex	NA	minichromosome maintenance 9 homologous recombination repair factor [Source:HGNC Symbol%3BAcc:HGNC:21484]
ENSG00000180096	3.92	2.46	3.20	2.35	2.69	3.00	0.284046633104554	1.93873820772404	0.189111137484719	0.561592947575193	16:30378132-30395991:-	SEPT1	6;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0007056,biological_process spindle assembly involved in female meiosis;GO:0030496,cellular_component midbody;GO:0051311,biological_process meiotic metaphase plate congression;GO:0072687,cellular_component meiotic spindle	SEPT1; septin 1; K13737	septin 1 [Source:HGNC Symbol%3BAcc:HGNC:2879]
ENSG00000004975	32.99	34.50	33.41	32.87	31.32	31.76	0.0828693967465599	6.1871456750471	0.189142358921916	0.561592947575193	17:7225340-7234545:-	DVL2	53;GO:0001843,biological_process neural tube closure;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003007,biological_process heart morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007379,biological_process segment specification;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016235,cellular_component aggresome;GO:0016328,cellular_component lateral plasma membrane;GO:0016604,cellular_component nuclear body;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0022007,biological_process convergent extension involved in neural plate elongation;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030674,molecular_function protein binding, bridging;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034613,biological_process cellular protein localization;GO:0035282,biological_process segmentation;GO:0035329,biological_process hippo signaling;GO:0035556,biological_process intracellular signal transduction;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043621,molecular_function protein self-association;GO:0044340,biological_process canonical Wnt signaling pathway involved in regulation of cell proliferation;GO:0045177,cellular_component apical part of cell;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048365,molecular_function Rac GTPase binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051259,biological_process protein oligomerization;GO:0060029,biological_process convergent extension involved in organogenesis;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061024,biological_process membrane organization;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090103,biological_process cochlea morphogenesis;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1904886,biological_process beta-catenin destruction complex disassembly	DVL; segment polarity protein dishevelled; K02353	dishevelled segment polarity protein 2 [Source:HGNC Symbol%3BAcc:HGNC:3086]
ENSG00000108786	17.46	15.88	16.55	14.64	15.68	15.82	0.128829478247217	3.99710119664893	0.189194275846965	0.561592947575193	17:42549213-42555213:+	HSD17B1	17;GO:0003824,molecular_function catalytic activity;GO:0004303,molecular_function estradiol 17-beta-dehydrogenase activity;GO:0005496,molecular_function steroid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006703,biological_process estrogen biosynthetic process;GO:0008210,biological_process estrogen metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0047035,molecular_function testosterone dehydrogenase (NAD+) activity;GO:0055114,biological_process oxidation-reduction process;GO:0060348,biological_process bone development;GO:0061370,biological_process testosterone biosynthetic process;GO:0070401,molecular_function NADP+ binding;GO:0071248,biological_process cellular response to metal ion;GO:1903924,molecular_function estradiol binding	HSD17B1; 17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]; K00044	hydroxysteroid 17-beta dehydrogenase 1 [Source:HGNC Symbol%3BAcc:HGNC:5210]
ENSG00000001036	173.00	172.73	158.85	157.66	164.01	158.76	0.0821964257789118	7.8747310751238	0.189271143132381	0.561592947575193	6:143494810-143511690:-	FUCA2	18;GO:0004560,molecular_function alpha-L-fucosidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005975,biological_process carbohydrate metabolic process;GO:0006004,biological_process fucose metabolic process;GO:0008152,biological_process metabolic process;GO:0009617,biological_process response to bacterium;GO:0016139,biological_process glycoside catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome;GO:2000535,biological_process regulation of entry of bacterium into host cell	FUCA; alpha-L-fucosidase [EC:3.2.1.51]; K01206	fucosidase%2C alpha-L- 2%2C plasma [Source:HGNC Symbol%3BAcc:HGNC:4008]
ENSG00000187017	0.46	0.33	0.65	0.53	0.55	0.80	-0.346063801773276	1.3954509510604	0.18932961678224	0.561592947575193	1:6424787-6461370:+	ESPN	19;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005902,cellular_component microvillus;GO:0005903,cellular_component brush border;GO:0007605,biological_process sensory perception of sound;GO:0007626,biological_process locomotory behavior;GO:0015629,cellular_component actin cytoskeleton;GO:0017124,molecular_function SH3 domain binding;GO:0030046,biological_process parallel actin filament bundle assembly;GO:0031941,cellular_component filamentous actin;GO:0032420,cellular_component stereocilium;GO:0032421,cellular_component stereocilium bundle;GO:0032426,cellular_component stereocilium tip;GO:0042995,cellular_component cell projection;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051494,biological_process negative regulation of cytoskeleton organization	NA	espin [Source:HGNC Symbol%3BAcc:HGNC:13281]
ENSG00000144029	61.54	62.15	63.84	68.02	63.03	69.77	-0.0872503276988357	6.38762037882646	0.189394084036893	0.561592947575193	2:95087206-95149434:-	MRPS5	10;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5; K02988	mitochondrial ribosomal protein S5 [Source:HGNC Symbol%3BAcc:HGNC:14498]
ENSG00000088205	41.22	42.93	41.96	44.51	45.35	44.67	-0.0825812247196018	6.45152913917578	0.189415526003407	0.561592947575193	2:117814649-117832379:+	DDX18	15;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0071392,biological_process cellular response to estradiol stimulus	NA	DEAD-box helicase 18 [Source:HGNC Symbol%3BAcc:HGNC:2741]
ENSG00000128203	3.45	2.07	3.39	5.14	2.53	3.87	-0.344779440224539	1.99368858464826	0.189456968944667	0.561592947575193	22:26429272-26445015:+	ASPHD2	7;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0018193,biological_process peptidyl-amino acid modification;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	aspartate beta-hydroxylase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30437]
ENSG00000096433	92.34	84.00	97.52	88.18	82.86	88.52	0.0894479967528174	9.47799351265463	0.189490409306495	0.561592947575193	6:33620364-33696574:+	ITPR3	48;GO:0000822,molecular_function inositol hexakisphosphate binding;GO:0005216,molecular_function ion channel activity;GO:0005220,molecular_function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007613,biological_process memory;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030168,biological_process platelet activation;GO:0031095,cellular_component platelet dense tubular network membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043025,cellular_component neuronal cell body;GO:0043209,cellular_component myelin sheath;GO:0043235,cellular_component receptor complex;GO:0043533,molecular_function inositol 1,3,4,5 tetrakisphosphate binding;GO:0045177,cellular_component apical part of cell;GO:0048016,biological_process inositol phosphate-mediated signaling;GO:0050796,biological_process regulation of insulin secretion;GO:0050913,biological_process sensory perception of bitter taste;GO:0050916,biological_process sensory perception of sweet taste;GO:0050917,biological_process sensory perception of umami taste;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization;GO:0051592,biological_process response to calcium ion;GO:0055085,biological_process transmembrane transport;GO:0060291,biological_process long-term synaptic potentiation;GO:0060402,biological_process calcium ion transport into cytosol;GO:0070588,biological_process calcium ion transmembrane transport;GO:0070679,molecular_function inositol 1,4,5 trisphosphate binding;GO:1903779,biological_process regulation of cardiac conduction	ITPR3; inositol 1,4,5-triphosphate receptor type 3; K04960	inositol 1%2C4%2C5-trisphosphate receptor type 3 [Source:HGNC Symbol%3BAcc:HGNC:6182]
ENSG00000113810	72.11	72.34	69.30	75.47	78.53	73.63	-0.0792461551066515	8.15263324362886	0.189494957418442	0.561592947575193	3:160399273-160434962:+	SMC4	20;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000166,molecular_function nucleotide binding;GO:0000796,cellular_component condensin complex;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0010032,biological_process meiotic chromosome condensation;GO:0016607,cellular_component nuclear speck;GO:0030261,biological_process chromosome condensation;GO:0045132,biological_process meiotic chromosome segregation;GO:0046982,molecular_function protein heterodimerization activity;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0051383,biological_process kinetochore organization	NA	structural maintenance of chromosomes 4 [Source:HGNC Symbol%3BAcc:HGNC:14013]
ENSG00000064763	4.01	3.80	2.65	3.31	4.12	5.28	-0.274959680364157	2.65297792267333	0.189520088406709	0.561592947575193	12:29149102-29340980:+	FAR2	12;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0006629,biological_process lipid metabolic process;GO:0010025,biological_process wax biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0035336,biological_process long-chain fatty-acyl-CoA metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0080019,molecular_function fatty-acyl-CoA reductase (alcohol-forming) activity	FAR; alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84]; K13356	fatty acyl-CoA reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:25531]
ENSG00000108506	6.75	6.42	7.14	6.95	7.97	7.29	-0.112799760795169	4.69183536416842	0.189645082877869	0.561813381943838	17:61865366-61928016:-	INTS2	12;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016180,biological_process snRNA processing;GO:0031965,cellular_component nuclear membrane;GO:0032039,cellular_component integrator complex;GO:0034472,biological_process snRNA 3'-end processing;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:29241]
ENSG00000006453	57.36	48.25	57.13	62.03	52.10	63.62	-0.113261121177833	6.44839397983881	0.189684998286202	0.561813381943838	7:98291650-98401068:-	BAIAP2L1	22;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007009,biological_process plasma membrane organization;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009617,biological_process response to bacterium;GO:0015629,cellular_component actin cytoskeleton;GO:0030833,biological_process regulation of actin filament polymerization;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0051017,biological_process actin filament bundle assembly;GO:0051764,biological_process actin crosslink formation;GO:0070062,cellular_component extracellular exosome;GO:0070064,molecular_function proline-rich region binding;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization	NA	BAI1 associated protein 2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:21649]
ENSG00000171016	1.35	0.73	0.96	1.26	1.34	1.51	-0.387096166515887	0.793893213339628	0.189909873479909	0.562345243202793	15:55538889-55588947:-	PYGO1	13;GO:0001822,biological_process kidney development;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007286,biological_process spermatid development;GO:0007289,biological_process spermatid nucleus differentiation;GO:0009791,biological_process post-embryonic development;GO:0016055,biological_process Wnt signaling pathway;GO:0034504,biological_process protein localization to nucleus;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1904837,biological_process beta-catenin-TCF complex assembly	NA	pygopus family PHD finger 1 [Source:HGNC Symbol%3BAcc:HGNC:30256]
ENSG00000111667	35.94	40.06	35.37	39.82	43.05	37.37	-0.100546616024749	6.63681415333412	0.189956038161727	0.562347794348084	12:6852127-6866632:+	USP5	18;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043130,molecular_function ubiquitin binding;GO:0046872,molecular_function metal ion binding;GO:0071108,biological_process protein K48-linked deubiquitination	NA	ubiquitin specific peptidase 5 [Source:HGNC Symbol%3BAcc:HGNC:12628]
ENSG00000143222	93.60	100.53	91.82	94.60	87.95	87.02	0.0938438724639184	5.53932186850837	0.190071891712718	0.562556602725315	1:161152775-161158856:+	UFC1	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0070062,cellular_component extracellular exosome;GO:0071568,molecular_function UFM1 transferase activity;GO:0071569,biological_process protein ufmylation;GO:1990592,biological_process protein K69-linked ufmylation	NA	ubiquitin-fold modifier conjugating enzyme 1 [Source:HGNC Symbol%3BAcc:HGNC:26941]
ENSG00000177025	2.19	2.37	2.05	2.21	1.41	1.31	0.430624371967864	0.466068766770354	0.190266681848733	0.562955680613966	19:57958436-57974534:-	C19orf18	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	chromosome 19 open reading frame 18 [Source:HGNC Symbol%3BAcc:HGNC:28642]
ENSG00000185418	7.11	8.11	7.35	7.24	6.99	6.57	0.124257135797831	4.16211157047044	0.190315559442062	0.562955680613966	15:101653597-101724604:-	TARSL2	15;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004829,molecular_function threonine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006435,biological_process threonyl-tRNA aminoacylation;GO:0008150,biological_process biological_process;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0043039,biological_process tRNA aminoacylation	TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]; K01868	threonyl-tRNA synthetase like 2 [Source:HGNC Symbol%3BAcc:HGNC:24728]
ENSG00000197183	6.09	5.55	6.23	6.31	7.42	6.18	-0.136771099147646	4.00292150019338	0.190376896484938	0.562955680613966	20:32443058-32585074:-	NOL4L	3;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol	NA	nucleolar protein 4 like [Source:HGNC Symbol%3BAcc:HGNC:16106]
ENSG00000177169	17.31	13.83	16.87	15.33	14.83	14.80	0.112222427277733	5.61717205636895	0.190388137212393	0.562955680613966	12:131894650-131923167:+	ULK1	42;GO:0000166,molecular_function nucleotide binding;GO:0000407,cellular_component pre-autophagosomal structure;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005776,cellular_component autophagosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006914,biological_process autophagy;GO:0007165,biological_process signal transduction;GO:0007409,biological_process axonogenesis;GO:0008104,biological_process protein localization;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0031102,biological_process neuron projection regeneration;GO:0031175,biological_process neuron projection development;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031669,biological_process cellular response to nutrient levels;GO:0032045,cellular_component guanyl-nucleotide exchange factor complex;GO:0032403,molecular_function protein complex binding;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0042594,biological_process response to starvation;GO:0046777,biological_process protein autophosphorylation;GO:0048675,biological_process axon extension;GO:0051020,molecular_function GTPase binding;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:0075044,biological_process autophagy of host cells involved in interaction with symbiont;GO:0097629,cellular_component extrinsic component of omegasome membrane;GO:0097632,cellular_component extrinsic component of pre-autophagosomal structure membrane;GO:0097635,cellular_component extrinsic component of autophagosome membrane;GO:1990316,cellular_component ATG1/ULK1 kinase complex	ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]; K08269	unc-51 like autophagy activating kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:12558]
ENSG00000080371	34.11	34.69	40.56	39.93	41.01	38.86	-0.116847826494054	4.69933768434155	0.19049823827396	0.563147090186871	12:71754873-71800285:+	RAB21	34;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0008089,biological_process anterograde axonal transport;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0012506,cellular_component vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017157,biological_process regulation of exocytosis;GO:0019003,molecular_function GDP binding;GO:0030516,biological_process regulation of axon extension;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0032154,cellular_component cleavage furrow;GO:0032580,cellular_component Golgi cisterna membrane;GO:0043005,cellular_component neuron projection;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0098559,cellular_component cytoplasmic side of early endosome membrane;GO:1904115,cellular_component axon cytoplasm;GO:2000643,biological_process positive regulation of early endosome to late endosome transport	NA	RAB21%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:18263]
ENSG00000114978	122.94	106.33	115.29	119.01	122.78	128.70	-0.0900789654346796	6.27632881290768	0.190617392269939	0.563365164344464	2:74152527-74178898:-	MOB1A	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0035329,biological_process hippo signaling;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	MOB kinase activator 1A [Source:HGNC Symbol%3BAcc:HGNC:16015]
ENSG00000167608	0.77	1.26	1.07	1.05	0.52	0.80	0.374207702447888	1.09107650924002	0.19066843433366	0.563381879405789	19:54160107-54173250:-	TMC4	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane channel like 4 [Source:HGNC Symbol%3BAcc:HGNC:22998]
ENSG00000143669	5.52	4.69	5.33	4.84	5.04	4.81	0.0982911665770638	5.87107508748194	0.190715648764945	0.563387279419148	1:235661040-235883640:-	LYST	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0007040,biological_process lysosome organization;GO:0015031,biological_process protein transport;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030595,biological_process leukocyte chemotaxis;GO:0032438,biological_process melanosome organization;GO:0032510,biological_process endosome to lysosome transport via multivesicular body sorting pathway;GO:0033364,biological_process mast cell secretory granule organization;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0042742,biological_process defense response to bacterium;GO:0042832,biological_process defense response to protozoan;GO:0043473,biological_process pigmentation;GO:0051607,biological_process defense response to virus	NA	lysosomal trafficking regulator [Source:HGNC Symbol%3BAcc:HGNC:1968]
ENSG00000154719	35.92	35.52	33.16	42.02	35.62	36.02	-0.108461273761867	5.33286161500741	0.191123240304573	0.564457002593544	21:25585655-25607517:-	MRPL39	10;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L39 [Source:HGNC Symbol%3BAcc:HGNC:14027]
ENSG00000069329	104.76	103.86	100.91	106.13	111.08	111.94	-0.0769163460426266	8.09630950440398	0.191271210765242	0.564588092869206	16:46656131-46689518:-	VPS35	55;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0007040,biological_process lysosome organization;GO:0008565,molecular_function protein transporter activity;GO:0010008,cellular_component endosome membrane;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010821,biological_process regulation of mitochondrion organization;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016241,biological_process regulation of macroautophagy;GO:0030904,cellular_component retromer complex;GO:0030906,cellular_component retromer, cargo-selective complex;GO:0031647,biological_process regulation of protein stability;GO:0031648,biological_process protein destabilization;GO:0031748,molecular_function D1 dopamine receptor binding;GO:0032268,biological_process regulation of cellular protein metabolic process;GO:0032463,biological_process negative regulation of protein homooligomerization;GO:0033365,biological_process protein localization to organelle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0045056,biological_process transcytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050882,biological_process voluntary musculoskeletal movement;GO:0060161,biological_process positive regulation of dopamine receptor signaling pathway;GO:0061357,biological_process positive regulation of Wnt protein secretion;GO:0070062,cellular_component extracellular exosome;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0090326,biological_process positive regulation of locomotion involved in locomotory behavior;GO:0097422,cellular_component tubular endosome;GO:0099073,cellular_component mitochondrion-derived vesicle;GO:0099074,biological_process mitochondrion to lysosome transport;GO:0099639,biological_process neurotransmitter receptor transport, endosome to plasma membrane;GO:1901215,biological_process negative regulation of neuron death;GO:1902823,biological_process negative regulation of late endosome to lysosome transport;GO:1902950,biological_process regulation of dendritic spine maintenance;GO:1903181,biological_process positive regulation of dopamine biosynthetic process;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:1903828,biological_process negative regulation of cellular protein localization;GO:1905166,biological_process negative regulation of lysosomal protein catabolic process;GO:1990126,biological_process retrograde transport, endosome to plasma membrane;GO:2000331,biological_process regulation of terminal button organization	NA	VPS35%2C retromer complex component [Source:HGNC Symbol%3BAcc:HGNC:13487]
ENSG00000141956	2.56	1.96	2.22	1.91	2.10	2.03	0.180590722671358	3.31404904586506	0.191306701187469	0.564588092869206	21:41798224-41879482:-	PRDM15	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	PR/SET domain 15 [Source:HGNC Symbol%3BAcc:HGNC:13999]
ENSG00000111012	3.03	2.75	3.16	3.81	2.84	3.92	-0.225103291560031	2.45705493916951	0.191337549750681	0.564588092869206	12:57762333-57768986:-	CYP27B1	33;GO:0004497,molecular_function monooxygenase activity;GO:0004498,molecular_function calcidiol 1-monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006766,biological_process vitamin metabolic process;GO:0006816,biological_process calcium ion transport;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010956,biological_process negative regulation of calcidiol 1-monooxygenase activity;GO:0010980,biological_process positive regulation of vitamin D 24-hydroxylase activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037,molecular_function heme binding;GO:0030282,biological_process bone mineralization;GO:0030308,biological_process negative regulation of cell growth;GO:0030500,biological_process regulation of bone mineralization;GO:0031966,cellular_component mitochondrial membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0033280,biological_process response to vitamin D;GO:0034341,biological_process response to interferon-gamma;GO:0036378,biological_process calcitriol biosynthetic process from calciol;GO:0042359,biological_process vitamin D metabolic process;GO:0042369,biological_process vitamin D catabolic process;GO:0043627,biological_process response to estrogen;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0046697,biological_process decidualization;GO:0046872,molecular_function metal ion binding;GO:0055074,biological_process calcium ion homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0070314,biological_process G1 to G0 transition;GO:0070564,biological_process positive regulation of vitamin D receptor signaling pathway	CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]; K07438	cytochrome P450 family 27 subfamily B member 1 [Source:HGNC Symbol%3BAcc:HGNC:2606]
ENSG00000230797	2.72	2.14	3.03	4.09	2.58	3.21	-0.29656157517016	1.80423070944269	0.191349561483989	0.564588092869206	X:21855986-21858727:+	YY2	12;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	YY2 transcription factor [Source:HGNC Symbol%3BAcc:HGNC:31684]
ENSG00000164182	36.02	32.14	31.01	32.76	27.43	30.77	0.138434575939426	4.14506703887845	0.191534005057372	0.564998004937537	5:60945128-61153037:+	NDUFAF2	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0022904,biological_process respiratory electron transport chain;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0045333,biological_process cellular respiration;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0072593,biological_process reactive oxygen species metabolic process	NA	NADH:ubiquinone oxidoreductase complex assembly factor 2 [Source:HGNC Symbol%3BAcc:HGNC:28086]
ENSG00000123200	12.36	12.87	11.36	11.14	11.92	11.54	0.0902622352971844	5.90524226898951	0.191666123123366	0.565253406113172	13:45954464-46052759:-	ZC3H13	6;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 13 [Source:HGNC Symbol%3BAcc:HGNC:20368]
ENSG00000168175	42.86	44.47	39.25	39.93	38.70	39.89	0.102648066409356	4.91402331957174	0.191721708392179	0.565283032368675	14:55051630-55070192:+	MAPK1IP1L	1;GO:0005515,molecular_function protein binding	NA	mitogen-activated protein kinase 1 interacting protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:19840]
ENSG00000117394	502.52	398.91	519.45	591.56	433.20	562.81	-0.148211611769363	9.6455149743367	0.191770785884596	0.565293461217168	1:42925374-42959173:-	SLC2A1	54;GO:0000139,cellular_component Golgi membrane;GO:0001939,cellular_component female pronucleus;GO:0005215,molecular_function transporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0005911,cellular_component cell-cell junction;GO:0005989,biological_process lactose biosynthetic process;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0006970,biological_process response to osmotic stress;GO:0007565,biological_process female pregnancy;GO:0008643,biological_process carbohydrate transport;GO:0010827,biological_process regulation of glucose transport;GO:0014704,cellular_component intercalated disc;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0019900,molecular_function kinase binding;GO:0021987,biological_process cerebral cortex development;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0030018,cellular_component Z disc;GO:0030496,cellular_component midbody;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031982,cellular_component vesicle;GO:0032868,biological_process response to insulin;GO:0033300,molecular_function dehydroascorbic acid transporter activity;GO:0042149,biological_process cellular response to glucose starvation;GO:0042383,cellular_component sarcolemma;GO:0042470,cellular_component melanosome;GO:0042802,molecular_function identical protein binding;GO:0042908,biological_process xenobiotic transport;GO:0042910,molecular_function xenobiotic transporter activity;GO:0043621,molecular_function protein self-association;GO:0045121,cellular_component membrane raft;GO:0050796,biological_process regulation of insulin secretion;GO:0055056,molecular_function D-glucose transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0070837,biological_process dehydroascorbic acid transport;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071474,biological_process cellular hyperosmotic response;GO:0072562,cellular_component blood microparticle;GO:1904016,biological_process response to Thyroglobulin triiodothyronine;GO:1904659,biological_process glucose transmembrane transport	SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1; K07299	solute carrier family 2 member 1 [Source:HGNC Symbol%3BAcc:HGNC:11005]
ENSG00000061918	22.09	23.14	20.92	16.72	24.41	19.13	0.145262995541316	5.44938940495326	0.191862664179752	0.565430021477508	4:155758991-155807591:+	GUCY1B3	30;GO:0000166,molecular_function nucleotide binding;GO:0004016,molecular_function adenylate cyclase activity;GO:0004383,molecular_function guanylate cyclase activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006171,biological_process cAMP biosynthetic process;GO:0006182,biological_process cGMP biosynthetic process;GO:0007263,biological_process nitric oxide mediated signal transduction;GO:0008015,biological_process blood circulation;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0019934,biological_process cGMP-mediated signaling;GO:0020037,molecular_function heme binding;GO:0035556,biological_process intracellular signal transduction;GO:0038060,biological_process nitric oxide-cGMP-mediated signaling pathway;GO:0043167,molecular_function ion binding;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0047805,molecular_function cytidylate cyclase activity;GO:0048786,cellular_component presynaptic active zone;GO:0051879,molecular_function Hsp90 protein binding;GO:0071732,biological_process cellular response to nitric oxide;GO:0099555,biological_process trans-synaptic signaling by nitric oxide, modulating synaptic transmission	GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2]; K12319	guanylate cyclase 1 soluble subunit beta [Source:HGNC Symbol%3BAcc:HGNC:4687]
ENSG00000114904	13.61	13.02	13.17	14.12	13.10	16.06	-0.109023324476158	5.22937677269806	0.191981059920059	0.565644646757107	3:52708448-52770949:-	NEK4	26;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030145,molecular_function manganese ion binding;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:1900062,biological_process regulation of replicative cell aging;GO:2000772,biological_process regulation of cellular senescence;GO:2001020,biological_process regulation of response to DNA damage stimulus	NA	NIMA related kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:11399]
ENSG00000079246	164.16	178.87	155.71	175.21	185.87	173.67	-0.0893594928998114	8.57621177397577	0.192084707509665	0.56581572717548	2:216107463-216206303:+	XRCC5	66;GO:0000166,molecular_function nucleotide binding;GO:0000723,biological_process telomere maintenance;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003723,molecular_function RNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007420,biological_process brain development;GO:0008022,molecular_function protein C-terminus binding;GO:0008047,molecular_function enzyme activator activity;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032204,biological_process regulation of telomere maintenance;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032508,biological_process DNA duplex unwinding;GO:0032993,cellular_component protein-DNA complex;GO:0034774,cellular_component secretory granule lumen;GO:0042162,molecular_function telomeric DNA binding;GO:0042493,biological_process response to drug;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043564,cellular_component Ku70:Ku80 complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044877,molecular_function macromolecular complex binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048660,biological_process regulation of smooth muscle cell proliferation;GO:0050769,biological_process positive regulation of neurogenesis;GO:0051575,molecular_function 5'-deoxyribose-5-phosphate lyase activity;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060218,biological_process hematopoietic stem cell differentiation;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0070419,cellular_component nonhomologous end joining complex;GO:0071398,biological_process cellular response to fatty acid;GO:0071475,biological_process cellular hyperosmotic salinity response;GO:0071480,biological_process cellular response to gamma radiation;GO:0071481,biological_process cellular response to X-ray;GO:0075713,biological_process establishment of integrated proviral latency;GO:1904430,biological_process negative regulation of t-circle formation;GO:1990830,biological_process cellular response to leukemia inhibitory factor	XRCC5, KU80, G22P2; ATP-dependent DNA helicase 2 subunit 2; K10885	X-ray repair cross complementing 5 [Source:HGNC Symbol%3BAcc:HGNC:12833]
ENSG00000177731	58.71	60.22	56.19	62.46	60.22	63.88	-0.0799489905236768	7.94101676324107	0.192458361016637	0.566781882633337	17:18244835-18258916:-	FLII	17;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005903,cellular_component brush border;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0051014,biological_process actin filament severing;GO:0051015,molecular_function actin filament binding	NA	FLII%2C actin remodeling protein [Source:HGNC Symbol%3BAcc:HGNC:3750]
ENSG00000032444	24.09	25.32	22.00	21.15	23.55	22.66	0.0945437368436174	6.57803559524103	0.192579172389477	0.566812956997969	19:7534003-7561764:+	PNPLA6	12;GO:0004622,molecular_function lysophospholipase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0032502,biological_process developmental process;GO:0046470,biological_process phosphatidylcholine metabolic process;GO:0046475,biological_process glycerophospholipid catabolic process	NTE, NRE; lysophospholipid hydrolase [EC:3.1.1.5]; K14676	patatin like phospholipase domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:16268]
ENSG00000119965	7.67	9.66	7.83	8.41	6.19	7.58	0.181893541219992	3.40975975122805	0.192602930998426	0.566812956997969	10:122930902-122954403:-	C10orf88	1;GO:0042802,molecular_function identical protein binding	NA	chromosome 10 open reading frame 88 [Source:HGNC Symbol%3BAcc:HGNC:25822]
ENSG00000154479	0.66	0.28	0.35	0.88	0.31	0.74	-0.532647926804808	0.122349826465319	0.192639489315674	0.566812956997969	2:169645424-169694433:-	CCDC173	NA	NA	coiled-coil domain containing 173 [Source:HGNC Symbol%3BAcc:HGNC:25064]
ENSG00000189180	11.73	10.97	11.01	9.06	11.85	10.22	0.128444283352045	4.79454876503095	0.192651564132316	0.566812956997969	10:38010649-38065088:+	ZNF33A	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 33A [Source:HGNC Symbol%3BAcc:HGNC:13096]
ENSG00000123219	10.79	10.63	13.24	13.62	12.85	12.65	-0.15687022552224	3.58747972781289	0.193072837840286	0.567917804765751	5:65517765-65563171:-	CENPK	10;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0034080,biological_process CENP-A containing nucleosome assembly	NA	centromere protein K [Source:HGNC Symbol%3BAcc:HGNC:29479]
ENSG00000251322	0.61	0.40	0.30	0.26	0.44	0.31	0.403505420831192	1.11495661860325	0.193222575960874	0.567980391123899	22:50674414-50733298:+	SHANK3	46;GO:0000165,biological_process MAPK cascade;GO:0001838,biological_process embryonic epithelial tube formation;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007416,biological_process synapse assembly;GO:0007611,biological_process learning or memory;GO:0007612,biological_process learning;GO:0007613,biological_process memory;GO:0007626,biological_process locomotory behavior;GO:0008022,molecular_function protein C-terminus binding;GO:0021773,biological_process striatal medium spiny neuron differentiation;GO:0032232,biological_process negative regulation of actin filament bundle assembly;GO:0035176,biological_process social behavior;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035640,biological_process exploration behavior;GO:0035641,biological_process locomotory exploration behavior;GO:0040011,biological_process locomotion;GO:0043005,cellular_component neuron projection;GO:0044309,cellular_component neuron spine;GO:0045794,biological_process negative regulation of cell volume;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048170,biological_process positive regulation of long-term neuronal synaptic plasticity;GO:0048854,biological_process brain morphogenesis;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051835,biological_process positive regulation of synapse structural plasticity;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060291,biological_process long-term synaptic potentiation;GO:0060292,biological_process long term synaptic depression;GO:0060997,biological_process dendritic spine morphogenesis;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0071625,biological_process vocalization behavior;GO:0097107,biological_process postsynaptic density assembly;GO:0097110,molecular_function scaffold protein binding;GO:0097113,biological_process AMPA glutamate receptor clustering;GO:0097114,biological_process NMDA glutamate receptor clustering;GO:0097117,biological_process guanylate kinase-associated protein clustering;GO:1900271,biological_process regulation of long-term synaptic potentiation;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1900451,biological_process positive regulation of glutamate receptor signaling pathway;GO:1900452,biological_process regulation of long term synaptic depression;GO:1904717,biological_process regulation of AMPA glutamate receptor clustering;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000821,biological_process regulation of grooming behavior;GO:2000822,biological_process regulation of behavioral fear response;GO:2000969,biological_process positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	SHANK; SH3 and multiple ankyrin repeat domains protein; K15009	SH3 and multiple ankyrin repeat domains 3 [Source:HGNC Symbol%3BAcc:HGNC:14294]
ENSG00000173320	1.44	1.35	1.30	1.30	1.89	1.68	-0.234350573245567	2.29639223351453	0.19324742484249	0.567980391123899	4:183797691-184023526:+	STOX2	4;GO:0001893,biological_process maternal placenta development;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0009790,biological_process embryo development	NA	storkhead box 2 [Source:HGNC Symbol%3BAcc:HGNC:25450]
ENSG00000173875	12.21	12.20	12.60	10.89	11.68	11.97	0.111584484243912	4.4790176900551	0.193320874276633	0.567980391123899	19:12610917-12633840:+	ZNF791	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 791 [Source:HGNC Symbol%3BAcc:HGNC:26895]
ENSG00000204435	18.71	17.83	16.78	19.84	19.45	19.83	-0.136873180815019	3.7366490494318	0.193328631895774	0.567980391123899	6:31665235-31670343:+	CSNK2B	46;GO:0000785,cellular_component chromatin;GO:0003682,molecular_function chromatin binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005956,cellular_component protein kinase CK2 complex;GO:0006457,biological_process protein folding;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0007165,biological_process signal transduction;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016055,biological_process Wnt signaling pathway;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016363,cellular_component nuclear matrix;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019887,molecular_function protein kinase regulator activity;GO:0019904,molecular_function protein domain specific binding;GO:0031519,cellular_component PcG protein complex;GO:0032927,biological_process positive regulation of activin receptor signaling pathway;GO:0033211,biological_process adiponectin-activated signaling pathway;GO:0033574,biological_process response to testosterone;GO:0034774,cellular_component secretory granule lumen;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043312,biological_process neutrophil degranulation;GO:0043537,biological_process negative regulation of blood vessel endothelial cell migration;GO:0043623,biological_process cellular protein complex assembly;GO:0045859,biological_process regulation of protein kinase activity;GO:0046872,molecular_function metal ion binding;GO:0051101,biological_process regulation of DNA binding;GO:0061154,biological_process endothelial tube morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097421,biological_process liver regeneration;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904813,cellular_component ficolin-1-rich granule lumen	CSNK2B; casein kinase II subunit beta; K03115	casein kinase 2 beta [Source:HGNC Symbol%3BAcc:HGNC:2460]
ENSG00000170417	4.10	3.06	3.40	4.35	4.31	4.25	-0.261174441579911	1.79920307319237	0.193333720199878	0.567980391123899	2:102736904-103019900:+	TMEM182	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 182 [Source:HGNC Symbol%3BAcc:HGNC:26391]
ENSG00000240303	25.30	21.20	26.03	23.34	20.37	23.98	0.114565461685116	5.85056995644499	0.193368656480271	0.567980391123899	3:132558137-132660723:-	ACAD11	16;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0004466,molecular_function long-chain-acyl-CoA dehydrogenase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005777,cellular_component peroxisome;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0017099,molecular_function very-long-chain-acyl-CoA dehydrogenase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0070991,molecular_function medium-chain-acyl-CoA dehydrogenase activity	NA	acyl-CoA dehydrogenase family member 11 [Source:HGNC Symbol%3BAcc:HGNC:30211]
ENSG00000135423	2.78	2.13	2.06	1.86	2.01	2.08	0.250379544413343	2.1102912996805	0.193545077243674	0.568364098373724	12:56470943-56488414:-	GLS2	14;GO:0004359,molecular_function glutaminase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006537,biological_process glutamate biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0006543,biological_process glutamine catabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0014047,biological_process glutamate secretion;GO:0016787,molecular_function hydrolase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0072593,biological_process reactive oxygen species metabolic process;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	glsA, GLS; glutaminase [EC:3.5.1.2]; K01425	glutaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:29570]
ENSG00000144560	28.70	26.22	27.31	27.46	26.04	23.42	0.112175679253002	4.95029041160537	0.193669124977323	0.568476724829849	3:11556069-11771350:-	VGLL4	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	vestigial like family member 4 [Source:HGNC Symbol%3BAcc:HGNC:28966]
ENSG00000175482	30.15	22.45	31.42	26.39	24.12	24.18	0.19658517064406	3.23811979216465	0.193689070645707	0.568476724829849	11:67350776-67356972:-	POLD4	23;GO:0000723,biological_process telomere maintenance;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0019985,biological_process translesion synthesis;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043625,cellular_component delta DNA polymerase complex	POLD4; DNA polymerase delta subunit 4; K03505	DNA polymerase delta 4%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:14106]
ENSG00000184497	6.98	5.99	3.84	4.69	4.90	4.41	0.274165174378505	2.46977945492634	0.193720820593753	0.568476724829849	13:113759239-113816995:+	TMEM255B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 255B [Source:HGNC Symbol%3BAcc:HGNC:28297]
ENSG00000102763	2.90	2.83	3.21	3.35	3.37	3.12	-0.123759896614981	4.17677180626974	0.193782726611302	0.568523986156014	13:41566836-41961120:-	VWA8	5;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005739,cellular_component mitochondrion;GO:0016887,molecular_function ATPase activity	NA	von Willebrand factor A domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:29071]
ENSG00000051596	22.70	23.02	19.42	23.15	23.72	23.86	-0.11070904557563	4.98423727503765	0.19389649498467	0.568723344103192	5:175917872-176034680:-	THOC3	18;GO:0000346,cellular_component transcription export complex;GO:0000445,cellular_component THO complex part of transcription export complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0046784,biological_process viral mRNA export from host cell nucleus;GO:0051028,biological_process mRNA transport	THOC3; THO complex subunit 3; K12880	THO complex 3 [Source:HGNC Symbol%3BAcc:HGNC:19072]
ENSG00000121057	12.64	14.24	13.88	13.50	12.38	12.33	0.101302079735492	5.21405756962777	0.193950285195343	0.568746725757098	17:57085091-57121349:+	AKAP1	11;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0007596,biological_process blood coagulation;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034237,molecular_function protein kinase A regulatory subunit binding	NA	A-kinase anchoring protein 1 [Source:HGNC Symbol%3BAcc:HGNC:367]
ENSG00000117305	60.96	54.12	55.78	61.65	59.11	62.45	-0.0866065703128423	6.15845858704456	0.194138906921751	0.569165387723122	1:23801884-23838620:-	HMGCL	24;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0000287,molecular_function magnesium ion binding;GO:0001889,biological_process liver development;GO:0003824,molecular_function catalytic activity;GO:0004419,molecular_function hydroxymethylglutaryl-CoA lyase activity;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005777,cellular_component peroxisome;GO:0006552,biological_process leucine catabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0007005,biological_process mitochondrion organization;GO:0007584,biological_process response to nutrient;GO:0016829,molecular_function lyase activity;GO:0030145,molecular_function manganese ion binding;GO:0031406,molecular_function carboxylic acid binding;GO:0042594,biological_process response to starvation;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0046951,biological_process ketone body biosynthetic process;GO:0051262,biological_process protein tetramerization;GO:0070542,biological_process response to fatty acid	E4.1.3.4, HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]; K01640	3-hydroxymethyl-3-methylglutaryl-CoA lyase [Source:HGNC Symbol%3BAcc:HGNC:5005]
ENSG00000168994	40.31	34.63	36.61	32.71	36.20	35.43	0.113272969886982	4.84287391031312	0.194255981677285	0.569302554729939	6:3722613-3752026:-	PXDC1	1;GO:0035091,molecular_function phosphatidylinositol binding	NA	PX domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21361]
ENSG00000146678	5.18	3.20	5.87	5.30	2.05	3.62	0.401828249255349	1.788366775278	0.194277420594217	0.569302554729939	7:45888356-45893668:+	IGFBP1	21;GO:0001558,biological_process regulation of cell growth;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0007165,biological_process signal transduction;GO:0007568,biological_process aging;GO:0008286,biological_process insulin receptor signaling pathway;GO:0019838,molecular_function growth factor binding;GO:0030307,biological_process positive regulation of cell growth;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0031995,molecular_function insulin-like growth factor II binding;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0042246,biological_process tissue regeneration;GO:0043567,biological_process regulation of insulin-like growth factor receptor signaling pathway;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	insulin like growth factor binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:5469]
ENSG00000135362	18.68	18.35	18.13	20.48	19.30	20.25	-0.110509136921032	4.41819853100388	0.194344782069336	0.569365536895601	11:36296287-36465204:+	PRR5L	13;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0009968,biological_process negative regulation of signal transduction;GO:0010762,biological_process regulation of fibroblast migration;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031932,cellular_component TORC2 complex;GO:0034599,biological_process cellular response to oxidative stress;GO:0038203,biological_process TORC2 signaling;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0090316,biological_process positive regulation of intracellular protein transport	NA	proline rich 5 like [Source:HGNC Symbol%3BAcc:HGNC:25878]
ENSG00000170100	2.36	2.27	2.46	2.87	2.64	2.72	-0.197549803431649	2.57900170634538	0.194402480514515	0.569384606012873	16:89217702-89237071:+	ZNF778	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 778 [Source:HGNC Symbol%3BAcc:HGNC:26479]
ENSG00000139372	13.72	15.32	15.00	13.09	13.51	14.05	0.121931382774009	4.14110367553968	0.194443031087454	0.569384606012873	12:103965803-103988874:+	TDG	42;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000287,molecular_function magnesium ion binding;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0004844,molecular_function uracil DNA N-glycosylase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006285,biological_process base-excision repair, AP site formation;GO:0006298,biological_process mismatch repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008134,molecular_function transcription factor binding;GO:0008263,molecular_function pyrimidine-specific mismatch base pair DNA N-glycosylase activity;GO:0009790,biological_process embryo development;GO:0016569,biological_process covalent chromatin modification;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0019904,molecular_function protein domain specific binding;GO:0030983,molecular_function mismatched DNA binding;GO:0031402,molecular_function sodium ion binding;GO:0031404,molecular_function chloride ion binding;GO:0032091,biological_process negative regulation of protein binding;GO:0032183,molecular_function SUMO binding;GO:0035511,biological_process oxidative DNA demethylation;GO:0035562,biological_process negative regulation of chromatin binding;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042803,molecular_function protein homodimerization activity;GO:0043621,molecular_function protein self-association;GO:0043739,molecular_function G/U mismatch-specific uracil-DNA glycosylase activity;GO:0045008,biological_process depyrimidination;GO:0080111,biological_process DNA demethylation;GO:1902544,biological_process regulation of DNA N-glycosylase activity	mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]; K03649	thymine DNA glycosylase [Source:HGNC Symbol%3BAcc:HGNC:11700]
ENSG00000105497	11.87	11.47	12.60	11.63	10.01	11.82	0.116526796813053	4.72233697323978	0.194545054703918	0.569549000952767	19:51571297-51592508:+	ZNF175	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 175 [Source:HGNC Symbol%3BAcc:HGNC:12964]
ENSG00000099942	29.29	28.39	29.39	33.85	29.54	31.25	-0.107041319670199	4.79317514788466	0.194648239808472	0.569716717930338	22:20917425-20953749:+	CRKL	23;GO:0000186,biological_process activation of MAPKK activity;GO:0001568,biological_process blood vessel development;GO:0001784,molecular_function phosphotyrosine binding;GO:0003723,molecular_function RNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0007254,biological_process JNK cascade;GO:0007265,biological_process Ras protein signal transduction;GO:0007389,biological_process pattern specification process;GO:0007507,biological_process heart development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0035556,biological_process intracellular signal transduction;GO:0045296,molecular_function cadherin binding;GO:0048538,biological_process thymus development;GO:0060017,biological_process parathyroid gland development;GO:0070062,cellular_component extracellular exosome;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	CRK, CRKII; proto-oncogene C-crk; K04438	CRK like proto-oncogene%2C adaptor protein [Source:HGNC Symbol%3BAcc:HGNC:2363]
ENSG00000204628	782.35	756.85	793.48	857.65	795.59	826.38	-0.0763454186794485	10.4191972768228	0.194712830249374	0.569771419586394	5:181236908-181248096:-	RACK1	81;GO:0001891,cellular_component phagocytic cup;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003723,molecular_function RNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007369,biological_process gastrulation;GO:0008200,molecular_function ion channel inhibitor activity;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0010629,biological_process negative regulation of gene expression;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0017148,biological_process negative regulation of translation;GO:0019899,molecular_function enzyme binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030292,molecular_function protein tyrosine kinase inhibitor activity;GO:0030308,biological_process negative regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0030425,cellular_component dendrite;GO:0030496,cellular_component midbody;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030822,biological_process positive regulation of cAMP catabolic process;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0032880,biological_process regulation of protein localization;GO:0032947,molecular_function protein complex scaffold;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0035591,molecular_function signaling adaptor activity;GO:0040008,biological_process regulation of growth;GO:0042169,molecular_function SH2 domain binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0042998,biological_process positive regulation of Golgi to plasma membrane protein transport;GO:0043005,cellular_component neuron projection;GO:0043022,molecular_function ribosome binding;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043204,cellular_component perikaryon;GO:0043473,biological_process pigmentation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044297,cellular_component cell body;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048511,biological_process rhythmic process;GO:0050765,biological_process negative regulation of phagocytosis;GO:0051302,biological_process regulation of cell division;GO:0051343,biological_process positive regulation of cyclic-nucleotide phosphodiesterase activity;GO:0051726,biological_process regulation of cell cycle;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0051901,biological_process positive regulation of mitochondrial depolarization;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity;GO:0065009,biological_process regulation of molecular function;GO:0070062,cellular_component extracellular exosome;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0072344,biological_process rescue of stalled ribosome;GO:1900102,biological_process negative regulation of endoplasmic reticulum unfolded protein response;GO:1903208,biological_process negative regulation of hydrogen peroxide-induced neuron death;GO:1990630,cellular_component IRE1-RACK1-PP2A complex;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000304,biological_process positive regulation of ceramide biosynthetic process;GO:2000543,biological_process positive regulation of gastrulation;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein; K14753	receptor for activated C kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:4399]
ENSG00000150776	32.76	28.91	30.57	31.61	33.64	35.08	-0.10530017199501	4.84113104809442	0.194812474617113	0.569928646576061	11:112074085-112085150:+	C11orf57	1;GO:0005515,molecular_function protein binding	NA	chromosome 11 open reading frame 57 [Source:HGNC Symbol%3BAcc:HGNC:25569]
ENSG00000146386	105.11	110.04	89.74	85.43	102.38	94.74	0.11835621403994	5.2325638496744	0.194861960082722	0.569939092956369	6:139028681-139043302:+	ABRACL	NA	NA	ABRA C-terminal like [Source:HGNC Symbol%3BAcc:HGNC:21230]
ENSG00000122873	50.79	49.55	52.93	49.68	47.28	44.71	0.128682832088095	4.00736912833399	0.194957746297863	0.570031429989282	10:58269057-58289586:+	CISD1	10;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043457,biological_process regulation of cellular respiration;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0070062,cellular_component extracellular exosome	NA	CDGSH iron sulfur domain 1 [Source:HGNC Symbol%3BAcc:HGNC:30880]
ENSG00000122550	29.74	27.61	29.56	31.25	30.58	31.16	-0.0830389573235979	5.84350716641602	0.195148765778004	0.570031429989282	7:23105757-23177914:+	KLHL7	13;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	kelch like family member 7 [Source:HGNC Symbol%3BAcc:HGNC:15646]
ENSG00000121775	13.21	11.20	14.96	14.66	15.00	14.10	-0.131457421186361	4.37113208960556	0.195151215257458	0.570031429989282	1:32072030-32102866:+	TMEM39B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 39B [Source:HGNC Symbol%3BAcc:HGNC:25510]
ENSG00000141552	84.50	89.13	79.26	81.76	77.51	80.17	0.0876669681147275	5.90368258808154	0.195184409641499	0.570031429989282	17:81890789-81900991:+	ANAPC11	23;GO:0000278,biological_process mitotic cell cycle;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045842,biological_process positive regulation of mitotic metaphase/anaphase transition;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0097602,molecular_function cullin family protein binding	APC11; anaphase-promoting complex subunit 11; K03358	anaphase promoting complex subunit 11 [Source:HGNC Symbol%3BAcc:HGNC:14452]
ENSG00000115137	4.16	3.49	3.47	5.11	4.02	4.39	-0.262711085660122	1.87122879100404	0.195193860412698	0.570031429989282	2:24943635-24972094:-	DNAJC27	9;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071701,biological_process regulation of MAPK export from nucleus	NA	DnaJ heat shock protein family (Hsp40) member C27 [Source:HGNC Symbol%3BAcc:HGNC:30290]
ENSG00000159202	59.11	60.27	62.13	65.50	67.85	61.13	-0.0873268398776295	6.12430006613739	0.195237863733785	0.570031429989282	17:48908368-48929056:+	UBE2Z	15;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity	UBE2Z; ubiquitin-conjugating enzyme E2 Z [EC:2.3.2.23]; K10585	ubiquitin conjugating enzyme E2 Z [Source:HGNC Symbol%3BAcc:HGNC:25847]
ENSG00000168301	12.81	11.16	13.56	11.27	11.20	11.37	0.170873933774418	3.1099966971814	0.195260950992402	0.570031429989282	3:58492113-58502360:+	KCTD6	7;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0030506,molecular_function ankyrin binding;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043687,biological_process post-translational protein modification;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:22235]
ENSG00000055147	16.60	16.34	15.40	17.59	16.67	18.19	-0.108084492473335	4.67990736100128	0.195282406142588	0.570031429989282	5:153990127-154038936:-	FAM114A2	3;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0017076,molecular_function purine nucleotide binding	NA	family with sequence similarity 114 member A2 [Source:HGNC Symbol%3BAcc:HGNC:1333]
ENSG00000155111	17.96	17.70	18.67	18.59	19.19	21.20	-0.106371563528266	4.84033603066774	0.195327366985533	0.570031429989282	6:110609977-110815958:-	CDK19	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0050729,biological_process positive regulation of inflammatory response;GO:0071222,biological_process cellular response to lipopolysaccharide	NA	cyclin dependent kinase 19 [Source:HGNC Symbol%3BAcc:HGNC:19338]
ENSG00000138279	93.73	93.02	96.17	94.77	84.34	89.77	0.0854167696690476	7.07558399808032	0.195367730977892	0.570031429989282	10:73375100-73414076:-	ANXA7	28;GO:0003723,molecular_function RNA binding;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006914,biological_process autophagy;GO:0007599,biological_process hemostasis;GO:0008283,biological_process cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009651,biological_process response to salt stress;GO:0009992,biological_process cellular water homeostasis;GO:0010629,biological_process negative regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0030855,biological_process epithelial cell differentiation;GO:0031982,cellular_component vesicle;GO:0035176,biological_process social behavior;GO:0042584,cellular_component chromaffin granule membrane;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051592,biological_process response to calcium ion;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome	NA	annexin A7 [Source:HGNC Symbol%3BAcc:HGNC:545]
ENSG00000250067	8.49	7.57	10.14	9.22	6.30	7.29	0.219003566796443	3.09310181225676	0.19545642063424	0.570031429989282	19:19528860-19537581:+	YJEFN3	NA	NA	YjeF N-terminal domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:24785]
ENSG00000151348	65.18	69.49	61.52	61.60	61.78	63.00	0.0844354571383042	7.22656953320984	0.195456766310504	0.570031429989282	11:44095548-44245429:+	EXT2	27;GO:0000139,cellular_component Golgi membrane;GO:0001503,biological_process ossification;GO:0001707,biological_process mesoderm formation;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006486,biological_process protein glycosylation;GO:0007165,biological_process signal transduction;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0015014,biological_process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030154,biological_process cell differentiation;GO:0033692,biological_process cellular polysaccharide biosynthetic process;GO:0042328,molecular_function heparan sulfate N-acetylglucosaminyltransferase activity;GO:0043541,cellular_component UDP-N-acetylglucosamine transferase complex;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050508,molecular_function glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509,molecular_function N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity;GO:0070062,cellular_component extracellular exosome	EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2 [EC:2.4.1.224 2.4.1.225]; K02367	exostosin glycosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:3513]
ENSG00000100564	7.63	8.46	9.22	6.71	7.93	7.68	0.190460370199196	2.81707322817738	0.195490517801045	0.570031429989282	14:67581954-67600287:-	PIGH	13;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0003824,molecular_function catalytic activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006464,biological_process cellular protein modification process;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0017176,molecular_function phosphatidylinositol N-acetylglucosaminyltransferase activity	PIGH, GPI15; phosphatidylinositol N-acetylglucosaminyltransferase subunit H; K03858	phosphatidylinositol glycan anchor biosynthesis class H [Source:HGNC Symbol%3BAcc:HGNC:8964]
ENSG00000183891	20.60	18.41	15.13	16.76	14.47	16.77	0.183932546343112	3.23672670823633	0.19575222077337	0.570538687846384	2:19896642-19901986:-	TTC32	1;GO:0005515,molecular_function protein binding	NA	tetratricopeptide repeat domain 32 [Source:HGNC Symbol%3BAcc:HGNC:32954]
ENSG00000169499	34.08	36.78	35.74	32.16	34.99	33.61	0.0905884759216197	5.51583031489549	0.195756406310944	0.570538687846384	8:38901234-38973909:+	PLEKHA2	2;GO:0030165,molecular_function PDZ domain binding;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding	NA	pleckstrin homology domain containing A2 [Source:HGNC Symbol%3BAcc:HGNC:14336]
ENSG00000105810	8.09	8.21	8.13	7.96	6.75	7.12	0.172818538541251	2.94124675852385	0.195818070093818	0.570545774614072	7:92604920-92836594:-	CDK6	61;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0001726,cellular_component ruffle;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003323,biological_process type B pancreatic cell development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007219,biological_process Notch signaling pathway;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009615,biological_process response to virus;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0014002,biological_process astrocyte development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0021542,biological_process dentate gyrus development;GO:0021670,biological_process lateral ventricle development;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030332,molecular_function cyclin binding;GO:0033077,biological_process T cell differentiation in thymus;GO:0042063,biological_process gliogenesis;GO:0042127,biological_process regulation of cell proliferation;GO:0042995,cellular_component cell projection;GO:0043697,biological_process cell dedifferentiation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045646,biological_process regulation of erythrocyte differentiation;GO:0045656,biological_process negative regulation of monocyte differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048699,biological_process generation of neurons;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051301,biological_process cell division;GO:0060218,biological_process hematopoietic stem cell differentiation;GO:0097132,cellular_component cyclin D2-CDK6 complex;GO:0098770,molecular_function FBXO family protein binding;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904628,biological_process cellular response to phorbol 13-acetate 12-myristate;GO:2000145,biological_process regulation of cell motility;GO:2000773,biological_process negative regulation of cellular senescence	CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]; K02091	cyclin dependent kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:1777]
ENSG00000135605	5.78	4.80	6.42	4.59	5.13	5.50	0.180860054400381	3.37294467312427	0.195850764974669	0.570545774614072	4:48135782-48269864:-	TEC	34;GO:0000166,molecular_function nucleotide binding;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005543,molecular_function phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008289,molecular_function lipid binding;GO:0010543,biological_process regulation of platelet activation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0035556,biological_process intracellular signal transduction;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042246,biological_process tissue regeneration;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050853,biological_process B cell receptor signaling pathway	TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]; K07364	tec protein tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:11719]
ENSG00000198171	34.90	32.63	32.71	37.40	34.87	35.64	-0.0925934947393934	5.27100117044335	0.195937804027982	0.570659798656998	20:3190349-3204685:-	DDRGK1	24;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0030335,biological_process positive regulation of cell migration;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902808,biological_process positive regulation of cell cycle G1/S phase transition;GO:1903721,biological_process positive regulation of I-kappaB phosphorylation;GO:1905050,biological_process positive regulation of metallopeptidase activity;GO:1905552,biological_process positive regulation of protein localization to endoplasmic reticulum;GO:1905636,biological_process positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:1990592,biological_process protein K69-linked ufmylation	NA	DDRGK domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16110]
ENSG00000046889	12.15	12.18	13.73	12.01	12.47	11.50	0.0948193639554111	5.89849448901545	0.196058680729091	0.570659798656998	8:67952117-68237030:+	PREX2	16;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008344,biological_process adult locomotory behavior;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0032007,biological_process negative regulation of TOR signaling;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048813,biological_process dendrite morphogenesis	NA	phosphatidylinositol-3%2C4%2C5-trisphosphate dependent Rac exchange factor 2 [Source:HGNC Symbol%3BAcc:HGNC:22950]
ENSG00000147649	74.67	70.39	74.19	78.30	76.75	78.61	-0.07912534601252	7.04530163071668	0.196070880995697	0.570659798656998	8:97644178-97728770:+	MTDH	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001650,cellular_component fibrillar center;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005923,cellular_component bicellular tight junction;GO:0010508,biological_process positive regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016604,cellular_component nuclear body;GO:0030054,cellular_component cell junction;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0031965,cellular_component nuclear membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046581,cellular_component intercellular canaliculus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051059,molecular_function NF-kappaB binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070830,biological_process bicellular tight junction assembly	NA	metadherin [Source:HGNC Symbol%3BAcc:HGNC:29608]
ENSG00000188186	89.12	98.19	98.13	88.45	91.12	90.54	0.0890890710641069	5.66371396560578	0.196073796928389	0.570659798656998	7:100148906-100155944:+	LAMTOR4	14;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0007050,biological_process cell cycle arrest;GO:0008361,biological_process regulation of cell size;GO:0016241,biological_process regulation of macroautophagy;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032947,molecular_function protein complex scaffold;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061462,biological_process protein localization to lysosome;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071986,cellular_component Ragulator complex	NA	late endosomal/lysosomal adaptor%2C MAPK and MTOR activator 4 [Source:HGNC Symbol%3BAcc:HGNC:33772]
ENSG00000110330	52.76	49.00	52.92	50.62	46.65	49.66	0.0874037921715081	6.57067444553403	0.196204504749405	0.570883446909279	11:102347210-102378670:+	BIRC2	64;GO:0000209,biological_process protein polyubiquitination;GO:0001666,biological_process response to hypoxia;GO:0001741,cellular_component XY body;GO:0001890,biological_process placenta development;GO:0003713,molecular_function transcription coactivator activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0008270,molecular_function zinc ion binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010243,biological_process response to organonitrogen compound;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0014070,biological_process response to organic cyclic compound;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034121,biological_process regulation of toll-like receptor signaling pathway;GO:0035631,cellular_component CD40 receptor complex;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0039535,biological_process regulation of RIG-I signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0045088,biological_process regulation of innate immune response;GO:0045121,cellular_component membrane raft;GO:0045471,biological_process response to ethanol;GO:0045595,biological_process regulation of cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0050727,biological_process regulation of inflammatory response;GO:0051087,molecular_function chaperone binding;GO:0051291,biological_process protein heterooligomerization;GO:0051591,biological_process response to cAMP;GO:0051726,biological_process regulation of cell cycle;GO:0060544,biological_process regulation of necroptotic process;GO:0060546,biological_process negative regulation of necroptotic process;GO:0070266,biological_process necroptotic process;GO:0070424,biological_process regulation of nucleotide-binding oligomerization domain containing signaling pathway;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0097194,biological_process execution phase of apoptosis;GO:0098770,molecular_function FBXO family protein binding;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling;GO:1902443,biological_process negative regulation of ripoptosome assembly involved in necroptotic process;GO:1902523,biological_process positive regulation of protein K63-linked ubiquitination;GO:1902524,biological_process positive regulation of protein K48-linked ubiquitination;GO:1902527,biological_process positive regulation of protein monoubiquitination;GO:1902916,biological_process positive regulation of protein polyubiquitination;GO:1903506,biological_process regulation of nucleic acid-templated transcription;GO:1990001,biological_process inhibition of cysteine-type endopeptidase activity involved in apoptotic process;GO:2000116,biological_process regulation of cysteine-type endopeptidase activity;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	BIRC2_3; baculoviral IAP repeat-containing protein 2/3; K16060	baculoviral IAP repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:590]
ENSG00000108561	111.95	119.85	105.01	117.97	119.32	123.60	-0.0900924600181809	6.62277326354842	0.196242622086675	0.570883446909279	17:5432776-5448830:-	C1QBP	52;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001849,molecular_function complement component C1q binding;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0003714,molecular_function transcription corepressor activity;GO:0003729,molecular_function mRNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0006958,biological_process complement activation, classical pathway;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0008134,molecular_function transcription factor binding;GO:0008380,biological_process RNA splicing;GO:0009986,cellular_component cell surface;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0030449,biological_process regulation of complement activation;GO:0030984,molecular_function kininogen binding;GO:0031690,molecular_function adrenergic receptor binding;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032695,biological_process negative regulation of interleukin-12 production;GO:0039534,biological_process negative regulation of MDA-5 signaling pathway;GO:0039536,biological_process negative regulation of RIG-I signaling pathway;GO:0042254,biological_process ribosome biogenesis;GO:0042256,biological_process mature ribosome assembly;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045087,biological_process innate immune response;GO:0045785,biological_process positive regulation of cell adhesion;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0050687,biological_process negative regulation of defense response to virus;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070131,biological_process positive regulation of mitochondrial translation;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:0097177,molecular_function mitochondrial ribosome binding;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1901165,biological_process positive regulation of trophoblast cell migration;GO:2000510,biological_process positive regulation of dendritic cell chemotaxis	NA	complement C1q binding protein [Source:HGNC Symbol%3BAcc:HGNC:1243]
ENSG00000120437	68.73	85.38	59.76	58.97	74.51	60.64	0.14941766138381	6.33926862145141	0.19631899261794	0.57097180303807	6:159760327-159779055:+	ACAT2	16;GO:0003824,molecular_function catalytic activity;GO:0003985,molecular_function acetyl-CoA C-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0070062,cellular_component extracellular exosome	E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]; K00626	acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:94]
ENSG00000142166	32.46	35.52	32.51	28.59	32.09	33.79	0.0975119502962372	5.76604375053309	0.196430254872868	0.571093744833901	21:33324476-33359862:+	IFNAR1	28;GO:0004904,molecular_function interferon receptor activity;GO:0004905,molecular_function type I interferon receptor activity;GO:0004920,molecular_function interleukin-10 receptor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007259,biological_process JAK-STAT cascade;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019962,molecular_function type I interferon binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0035457,biological_process cellular response to interferon-alpha;GO:0042110,biological_process T cell activation;GO:0045351,biological_process type I interferon biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0060759,biological_process regulation of response to cytokine stimulus	IFNAR1; interferon receptor 1; K05130	interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:5432]
ENSG00000160714	35.65	38.12	39.07	36.61	35.47	34.66	0.0909526930541895	5.53840930421792	0.196474834997397	0.571093744833901	1:154548576-154559028:-	UBE2Q1	17;GO:0000166,molecular_function nucleotide binding;GO:0001967,biological_process suckling behavior;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007566,biological_process embryo implantation;GO:0007617,biological_process mating behavior;GO:0009566,biological_process fertilization;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030175,cellular_component filopodium;GO:0042995,cellular_component cell projection;GO:0061458,biological_process reproductive system development;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070459,biological_process prolactin secretion	UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]; K10582	ubiquitin conjugating enzyme E2 Q1 [Source:HGNC Symbol%3BAcc:HGNC:15698]
ENSG00000170703	3.67	3.76	3.75	3.74	4.09	4.70	-0.155873990214775	3.59978322116463	0.196538793797819	0.571093744833901	17:48762234-48817214:-	TTLL6	19;GO:0000166,molecular_function nucleotide binding;GO:0001578,biological_process microtubule bundle formation;GO:0003353,biological_process positive regulation of cilium movement;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0006464,biological_process cellular protein modification process;GO:0015631,molecular_function tubulin binding;GO:0016874,molecular_function ligase activity;GO:0018095,biological_process protein polyglutamylation;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0051013,biological_process microtubule severing;GO:0070739,molecular_function protein-glutamic acid ligase activity;GO:0070740,molecular_function tubulin-glutamic acid ligase activity	NA	tubulin tyrosine ligase like 6 [Source:HGNC Symbol%3BAcc:HGNC:26664]
ENSG00000164171	3.70	3.20	3.33	3.13	2.96	3.24	0.149562356975033	3.56827657052219	0.196544951094048	0.571093744833901	5:52989325-53094779:+	ITGA2	73;GO:0001618,molecular_function virus receptor activity;GO:0001666,biological_process response to hypoxia;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006929,biological_process substrate-dependent cell migration;GO:0006971,biological_process hypotonic response;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007565,biological_process female pregnancy;GO:0007596,biological_process blood coagulation;GO:0008283,biological_process cell proliferation;GO:0008305,cellular_component integrin complex;GO:0009887,biological_process organ morphogenesis;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010694,biological_process positive regulation of alkaline phosphatase activity;GO:0014070,biological_process response to organic cyclic compound;GO:0014075,biological_process response to amine;GO:0014850,biological_process response to muscle activity;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030198,biological_process extracellular matrix organization;GO:0030424,cellular_component axon;GO:0030879,biological_process mammary gland development;GO:0031346,biological_process positive regulation of cell projection organization;GO:0031589,biological_process cell-substrate adhesion;GO:0032403,molecular_function protein complex binding;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0033343,biological_process positive regulation of collagen binding;GO:0033591,biological_process response to L-ascorbic acid;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0034666,cellular_component integrin alpha2-beta1 complex;GO:0038064,molecular_function collagen receptor activity;GO:0038065,biological_process collagen-activated signaling pathway;GO:0042060,biological_process wound healing;GO:0042493,biological_process response to drug;GO:0042995,cellular_component cell projection;GO:0043236,molecular_function laminin binding;GO:0043388,biological_process positive regulation of DNA binding;GO:0043589,biological_process skin morphogenesis;GO:0043679,cellular_component axon terminus;GO:0045178,cellular_component basal part of cell;GO:0045184,biological_process establishment of protein localization;GO:0045727,biological_process positive regulation of translation;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048041,biological_process focal adhesion assembly;GO:0048333,biological_process mesodermal cell differentiation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0050966,biological_process detection of mechanical stimulus involved in sensory perception of pain;GO:0051971,biological_process positive regulation of transmission of nerve impulse;GO:0060100,biological_process positive regulation of phagocytosis, engulfment;GO:0070365,biological_process hepatocyte differentiation;GO:0071107,biological_process response to parathyroid hormone;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0098639,molecular_function collagen binding involved in cell-matrix adhesion	ITGA2, CD49b; integrin alpha 2; K06481	integrin subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:6137]
ENSG00000163818	29.63	28.70	30.99	28.88	34.87	33.29	-0.105974187419317	5.27762699983085	0.196605257363555	0.571135281922257	3:45823315-45916042:-	LZTFL1	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0032403,molecular_function protein complex binding;GO:0042802,molecular_function identical protein binding;GO:1903565,biological_process negative regulation of protein localization to cilium;GO:1903568,biological_process negative regulation of protein localization to ciliary membrane	NA	leucine zipper transcription factor like 1 [Source:HGNC Symbol%3BAcc:HGNC:6741]
ENSG00000100030	59.05	62.12	58.81	62.67	62.50	67.13	-0.086085608566033	6.07030482560795	0.196894273319537	0.571606716727619	22:21754499-21867680:-	MAPK1	125;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0000189,biological_process MAPK import into nucleus;GO:0001784,molecular_function phosphotyrosine binding;GO:0003677,molecular_function DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006935,biological_process chemotaxis;GO:0006950,biological_process response to stress;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007268,biological_process chemical synaptic transmission;GO:0007411,biological_process axon guidance;GO:0007507,biological_process heart development;GO:0007611,biological_process learning or memory;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009636,biological_process response to toxic substance;GO:0009887,biological_process organ morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0014032,biological_process neural crest cell development;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0015966,biological_process diadenosine tetraphosphate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019233,biological_process sensory perception of pain;GO:0019858,biological_process cytosine metabolic process;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0030168,biological_process platelet activation;GO:0030278,biological_process regulation of ossification;GO:0030335,biological_process positive regulation of cell migration;GO:0030424,cellular_component axon;GO:0030641,biological_process regulation of cellular pH;GO:0030878,biological_process thyroid gland development;GO:0031143,cellular_component pseudopodium;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0031647,biological_process regulation of protein stability;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032496,biological_process response to lipopolysaccharide;GO:0032839,cellular_component dendrite cytoplasm;GO:0032872,biological_process regulation of stress-activated MAPK cascade;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035094,biological_process response to nicotine;GO:0035556,biological_process intracellular signal transduction;GO:0035578,cellular_component azurophil granule lumen;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038127,biological_process ERBB signaling pathway;GO:0042473,biological_process outer ear morphogenesis;GO:0042802,molecular_function identical protein binding;GO:0043204,cellular_component perikaryon;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043330,biological_process response to exogenous dsRNA;GO:0043627,biological_process response to estrogen;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045727,biological_process positive regulation of translation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048538,biological_process thymus development;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060291,biological_process long-term synaptic potentiation;GO:0060324,biological_process face development;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway;GO:0060425,biological_process lung morphogenesis;GO:0060440,biological_process trachea formation;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0061308,biological_process cardiac neural crest cell development involved in heart development;GO:0070062,cellular_component extracellular exosome;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070849,biological_process response to epidermal growth factor;GO:0071276,biological_process cellular response to cadmium ion;GO:0071310,biological_process cellular response to organic substance;GO:0072584,biological_process caveolin-mediated endocytosis;GO:0072686,cellular_component mitotic spindle;GO:0090170,biological_process regulation of Golgi inheritance;GO:0097011,biological_process cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1900034,biological_process regulation of cellular response to heat;GO:1903351,biological_process cellular response to dopamine;GO:1904355,biological_process positive regulation of telomere capping;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2000641,biological_process regulation of early endosome to late endosome transport	ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]; K04371	mitogen-activated protein kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:6871]
ENSG00000109061	0.19	0.21	0.18	0.18	0.13	0.10	0.526182295435038	0.14083551650118	0.19695642350979	0.571606716727619	17:10492306-10518543:-	MYH1	15;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005859,cellular_component muscle myosin complex;GO:0006936,biological_process muscle contraction;GO:0014704,cellular_component intercalated disc;GO:0016459,cellular_component myosin complex;GO:0030016,cellular_component myofibril;GO:0031672,cellular_component A band;GO:0032982,cellular_component myosin filament;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule	MYH; myosin heavy chain; K10352	myosin heavy chain 1 [Source:HGNC Symbol%3BAcc:HGNC:7567]
ENSG00000179085	42.84	48.30	37.60	41.73	35.02	39.58	0.149090318764176	3.91123085872826	0.197011056192589	0.571606716727619	1:155139890-155140595:-	DPM3	17;GO:0004582,molecular_function dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0018406,biological_process protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0031501,cellular_component mannosyltransferase complex;GO:0031647,biological_process regulation of protein stability;GO:0033185,cellular_component dolichol-phosphate-mannose synthase complex;GO:0035268,biological_process protein mannosylation;GO:0035269,biological_process protein O-linked mannosylation	DPM3; dolichol-phosphate mannosyltransferase subunit 3; K09659	dolichyl-phosphate mannosyltransferase subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:3007]
ENSG00000171621	34.06	34.77	32.17	32.00	32.60	29.96	0.105442832709875	4.74538283321836	0.19701119215472	0.571606716727619	1:9292879-9369532:+	SPSB1	9;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	splA/ryanodine receptor domain and SOCS box containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30628]
ENSG00000106780	8.33	7.67	6.11	7.84	8.73	8.29	-0.158488280846606	3.83875536687102	0.197036820997768	0.571606716727619	9:120600812-120714470:-	MEGF9	5;GO:0005575,cellular_component cellular_component;GO:0005604,cellular_component basement membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	multiple EGF like domains 9 [Source:HGNC Symbol%3BAcc:HGNC:3234]
ENSG00000137822	15.59	14.08	13.62	13.11	14.60	12.68	0.114721569676994	4.89687699501626	0.197060609143013	0.571606716727619	15:43369220-43409771:+	TUBGCP4	25;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000922,cellular_component spindle pole;GO:0000923,cellular_component equatorial microtubule organizing center;GO:0000930,cellular_component gamma-tubulin complex;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006461,biological_process protein complex assembly;GO:0007020,biological_process microtubule nucleation;GO:0008274,cellular_component gamma-tubulin ring complex;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0043015,molecular_function gamma-tubulin binding;GO:0051011,molecular_function microtubule minus-end binding;GO:0051298,biological_process centrosome duplication;GO:0051321,biological_process meiotic cell cycle;GO:0051415,biological_process interphase microtubule nucleation by interphase microtubule organizing center;GO:0055037,cellular_component recycling endosome;GO:0090307,biological_process mitotic spindle assembly	NA	tubulin gamma complex associated protein 4 [Source:HGNC Symbol%3BAcc:HGNC:16691]
ENSG00000132549	6.63	6.72	7.10	6.26	6.79	6.37	0.0857984992895691	6.35002571484592	0.19708988540999	0.571606716727619	8:99013265-99877580:+	VPS13B	2;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport	NA	vacuolar protein sorting 13 homolog B [Source:HGNC Symbol%3BAcc:HGNC:2183]
ENSG00000178950	20.79	21.50	21.40	19.91	20.84	19.90	0.0816030007599082	6.42982980924947	0.197335730374272	0.572186036238225	4:849275-932373:-	GAK	35;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007030,biological_process Golgi organization;GO:0007049,biological_process cell cycle;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016191,biological_process synaptic vesicle uncoating;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0030332,molecular_function cyclin binding;GO:0031982,cellular_component vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045202,cellular_component synapse;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051087,molecular_function chaperone binding;GO:0061024,biological_process membrane organization;GO:0072318,biological_process clathrin coat disassembly;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0072600,biological_process establishment of protein localization to Golgi;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0090160,biological_process Golgi to lysosome transport;GO:1905224,biological_process clathrin-coated pit assembly	NA	cyclin G associated kinase [Source:HGNC Symbol%3BAcc:HGNC:4113]
ENSG00000196652	11.73	10.37	9.77	11.84	11.18	11.73	-0.111308492734483	4.81518183547249	0.197547830584977	0.572667263206755	7:99504650-99534700:+	ZKSCAN5	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger with KRAB and SCAN domains 5 [Source:HGNC Symbol%3BAcc:HGNC:12867]
ENSG00000165792	36.99	37.29	37.46	38.89	40.56	39.68	-0.0808663423157607	5.9709671651147	0.197630733359598	0.572740712328221	14:20989769-20997035:+	METTL17	8;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032259,biological_process methylation	NA	methyltransferase like 17 [Source:HGNC Symbol%3BAcc:HGNC:19280]
ENSG00000179627	1.00	0.83	1.40	1.30	1.74	1.28	-0.379182034426853	0.815487825583275	0.197665448450342	0.572740712328221	14:104800595-104804712:+	ZBTB42	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007517,biological_process muscle organ development;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 42 [Source:HGNC Symbol%3BAcc:HGNC:32550]
ENSG00000219481	9.38	9.68	10.38	9.86	10.59	11.46	-0.104854646792932	5.13519660522265	0.197878211882901	0.573223394189604	1:16562318-16613562:-	NBPF1	2;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	NBPF member 1 [Source:HGNC Symbol%3BAcc:HGNC:26088]
ENSG00000013441	49.25	44.43	47.82	40.63	45.38	47.67	0.0955996169691452	6.19850103075758	0.198149265293997	0.573706109720174	2:200853008-200864744:-	CLK1	20;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0008283,biological_process cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0043484,biological_process regulation of RNA splicing;GO:0046777,biological_process protein autophosphorylation	NA	CDC like kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:2068]
ENSG00000172809	757.17	646.29	670.28	773.44	675.53	795.41	-0.101411581722702	7.27677894233221	0.198150572065944	0.573706109720174	17:74203581-74210655:+	RPL38	23;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007605,biological_process sensory perception of sound;GO:0019083,biological_process viral transcription;GO:0022618,biological_process ribonucleoprotein complex assembly;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033291,cellular_component eukaryotic 80S initiation complex;GO:0034463,biological_process 90S preribosome assembly;GO:0042474,biological_process middle ear morphogenesis;GO:0048318,biological_process axial mesoderm development	RP-L38e, RPL38; large subunit ribosomal protein L38e; K02923	ribosomal protein L38 [Source:HGNC Symbol%3BAcc:HGNC:10349]
ENSG00000174996	15.06	12.75	14.22	12.49	13.24	13.68	0.110129920570019	4.97954271779013	0.19825076887511	0.573706109720174	11:66257293-66267860:+	KLC2	15;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0016020,cellular_component membrane;GO:0016938,cellular_component kinesin I complex;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019894,molecular_function kinesin binding;GO:0043234,cellular_component protein complex;GO:0045296,molecular_function cadherin binding	KLC; kinesin light chain; K10407	kinesin light chain 2 [Source:HGNC Symbol%3BAcc:HGNC:20716]
ENSG00000161021	9.71	8.81	8.43	9.68	10.25	9.39	-0.107250740746003	4.84690684666927	0.198258738389541	0.573706109720174	5:179732849-179777286:+	MAML1	21;GO:0002193,cellular_component MAML1-RBP-Jkappa- ICN1 complex;GO:0003162,biological_process atrioventricular node development;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007219,biological_process Notch signaling pathway;GO:0007221,biological_process positive regulation of transcription of Notch receptor target;GO:0010831,biological_process positive regulation of myotube differentiation;GO:0016607,cellular_component nuclear speck;GO:0019901,molecular_function protein kinase binding;GO:0042605,molecular_function peptide antigen binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045445,biological_process myoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0060928,biological_process atrioventricular node cell development	MAML; mastermind; K06061	mastermind like transcriptional coactivator 1 [Source:HGNC Symbol%3BAcc:HGNC:13632]
ENSG00000032742	8.44	6.59	7.95	8.56	8.52	8.32	-0.122289656620241	4.35653106085906	0.198291816555814	0.573706109720174	13:20567068-20691437:+	IFT88	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0031514,cellular_component motile cilium;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip;GO:1902017,biological_process regulation of cilium assembly;GO:2000785,biological_process regulation of autophagosome assembly	NA	intraflagellar transport 88 [Source:HGNC Symbol%3BAcc:HGNC:20606]
ENSG00000075618	196.55	214.33	179.40	178.24	194.81	184.04	0.0945404877401855	8.14506193083565	0.198322155547351	0.573706109720174	7:5592822-5606655:+	FSCN1	43;GO:0001725,cellular_component stress fiber;GO:0001726,cellular_component ruffle;GO:0002102,cellular_component podosome;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005902,cellular_component microvillus;GO:0005911,cellular_component cell-cell junction;GO:0007015,biological_process actin filament organization;GO:0007043,biological_process cell-cell junction assembly;GO:0008144,molecular_function drug binding;GO:0008283,biological_process cell proliferation;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0015629,cellular_component actin cytoskeleton;GO:0016477,biological_process cell migration;GO:0030027,cellular_component lamellipodium;GO:0030035,biological_process microspike assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030426,cellular_component growth cone;GO:0030674,molecular_function protein binding, bridging;GO:0031253,cellular_component cell projection membrane;GO:0031941,cellular_component filamentous actin;GO:0032534,biological_process regulation of microvillus assembly;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035089,biological_process establishment of apical/basal cell polarity;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0044393,cellular_component microspike;GO:0045296,molecular_function cadherin binding;GO:0048870,biological_process cell motility;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0070062,cellular_component extracellular exosome;GO:0071437,cellular_component invadopodium;GO:0071803,biological_process positive regulation of podosome assembly;GO:0090091,biological_process positive regulation of extracellular matrix disassembly	NA	fascin actin-bundling protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11148]
ENSG00000132773	7.34	6.50	6.11	7.54	7.39	7.45	-0.150060338239008	3.45578430482927	0.198528846102706	0.574157800861827	1:45339669-45343975:+	TOE1	15;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0003676,molecular_function nucleic acid binding;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0017069,molecular_function snRNA binding;GO:0034472,biological_process snRNA 3'-end processing;GO:0046872,molecular_function metal ion binding;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	target of EGR1%2C member 1 (nuclear) [Source:HGNC Symbol%3BAcc:HGNC:15954]
ENSG00000113108	17.61	15.15	17.55	15.61	14.94	16.46	0.115318069343213	4.74527537290248	0.198597982673702	0.574157800861827	5:140558267-140564781:-	APBB3	8;GO:0001540,molecular_function beta-amyloid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0015629,cellular_component actin cytoskeleton	NA	amyloid beta precursor protein binding family B member 3 [Source:HGNC Symbol%3BAcc:HGNC:20708]
ENSG00000118496	14.50	12.44	12.84	14.27	13.88	15.10	-0.104436780556686	4.96205382747832	0.198693659737285	0.574157800861827	6:145793501-145814753:-	FBXO30	8;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	F-box protein 30 [Source:HGNC Symbol%3BAcc:HGNC:15600]
ENSG00000025772	33.37	36.60	31.52	31.26	31.66	32.01	0.102235965566065	4.92839358461124	0.198750663723208	0.574157800861827	20:44942129-44960486:-	TOMM34	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006626,biological_process protein targeting to mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031072,molecular_function heat shock protein binding	NA	translocase of outer mitochondrial membrane 34 [Source:HGNC Symbol%3BAcc:HGNC:15746]
ENSG00000121152	17.59	18.48	15.95	17.57	20.42	18.42	-0.108156807557367	5.33711897583457	0.198798916393118	0.574157800861827	2:96335786-96373845:+	NCAPH	18;GO:0000796,cellular_component condensin complex;GO:0000799,cellular_component nuclear condensin complex;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0010032,biological_process meiotic chromosome condensation;GO:0016020,cellular_component membrane;GO:0030261,biological_process chromosome condensation;GO:0044547,molecular_function DNA topoisomerase binding;GO:0045132,biological_process meiotic chromosome segregation;GO:0051301,biological_process cell division;GO:0072587,molecular_function DNA topoisomerase (ATP-hydrolyzing) activator activity;GO:2000373,biological_process positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	NA	non-SMC condensin I complex subunit H [Source:HGNC Symbol%3BAcc:HGNC:1112]
ENSG00000125503	21.32	19.07	19.27	18.10	19.01	19.36	0.0934537697517804	5.57065441742073	0.198861205193969	0.574157800861827	19:55090912-55117559:-	PPP1R12C	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0019901,molecular_function protein kinase binding	PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C; K17457	protein phosphatase 1 regulatory subunit 12C [Source:HGNC Symbol%3BAcc:HGNC:14947]
ENSG00000164323	14.34	13.85	14.90	15.57	16.00	15.22	-0.10383526636128	4.62589053953566	0.1989079033388	0.574157800861827	4:185159664-185209504:-	CFAP97	NA	NA	cilia and flagella associated protein 97 [Source:HGNC Symbol%3BAcc:HGNC:29276]
ENSG00000164056	1.92	2.20	2.38	2.03	1.74	1.40	0.340560393569219	1.0017656646575	0.198961674574126	0.574157800861827	4:123396794-123403760:+	SPRY1	23;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0001656,biological_process metanephros development;GO:0001657,biological_process ureteric bud development;GO:0001759,biological_process organ induction;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0034260,biological_process negative regulation of GTPase activity;GO:0040037,biological_process negative regulation of fibroblast growth factor receptor signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0051387,biological_process negative regulation of neurotrophin TRK receptor signaling pathway;GO:0060449,biological_process bud elongation involved in lung branching;GO:0060940,biological_process epithelial to mesenchymal transition involved in cardiac fibroblast development;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	NA	sprouty RTK signaling antagonist 1 [Source:HGNC Symbol%3BAcc:HGNC:11269]
ENSG00000104881	16.92	16.96	17.85	16.16	16.51	16.45	0.0873548594854077	5.50319486418675	0.19902343478228	0.574157800861827	19:45379633-45406349:-	PPP1R13L	25;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0003229,biological_process ventricular cardiac muscle tissue development;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0008134,molecular_function transcription factor binding;GO:0009791,biological_process post-embryonic development;GO:0030054,cellular_component cell junction;GO:0031076,biological_process embryonic camera-type eye development;GO:0035264,biological_process multicellular organism growth;GO:0042633,biological_process hair cycle;GO:0042802,molecular_function identical protein binding;GO:0045171,cellular_component intercellular bridge;GO:0045296,molecular_function cadherin binding;GO:0045597,biological_process positive regulation of cell differentiation;GO:0048871,biological_process multicellular organismal homeostasis;GO:0060048,biological_process cardiac muscle contraction;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	protein phosphatase 1 regulatory subunit 13 like [Source:HGNC Symbol%3BAcc:HGNC:18838]
ENSG00000085231	46.91	49.03	46.28	49.31	51.65	52.87	-0.104979394095031	4.7340178040657	0.199068957819112	0.574157800861827	5:69350983-69370013:-	AK6	17;GO:0000166,molecular_function nucleotide binding;GO:0004017,molecular_function adenylate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0015030,cellular_component Cajal body;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046939,biological_process nucleotide phosphorylation;GO:0046940,biological_process nucleoside monophosphate phosphorylation;GO:0050145,molecular_function nucleoside phosphate kinase activity	TAF9; transcription initiation factor TFIID subunit 9; K14535	adenylate kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:49151]
ENSG00000066379	39.80	27.30	34.66	39.22	37.12	39.07	-0.155988193789976	3.80079557198569	0.199078963119265	0.574157800861827	6:30058898-30064909:+	ZNRD1	16;GO:0001054,molecular_function RNA polymerase I activity;GO:0003676,molecular_function nucleic acid binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006379,biological_process mRNA cleavage;GO:0008270,molecular_function zinc ion binding;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding	RPA12, ZNRD1; DNA-directed RNA polymerase I subunit RPA12; K03000	zinc ribbon domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:13182]
ENSG00000143156	49.42	38.18	44.32	47.20	47.17	49.20	-0.105056010412477	5.75457876700154	0.199110707502028	0.574157800861827	1:169132530-169367967:-	NME7	16;GO:0000166,molecular_function nucleotide binding;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006183,biological_process GTP biosynthetic process;GO:0006228,biological_process UTP biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0009117,biological_process nucleotide metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]; K00940	NME/NM23 family member 7 [Source:HGNC Symbol%3BAcc:HGNC:20461]
ENSG00000149136	113.84	117.89	115.71	121.91	122.82	124.08	-0.0746649553498222	7.9959623735227	0.199124774916488	0.574157800861827	11:57325984-57335877:-	SSRP1	16;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	structure specific recognition protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11327]
ENSG00000166681	321.95	332.33	310.76	321.30	295.63	299.86	0.0847618717315737	6.70897220345521	0.199150788860807	0.574157800861827	X:103376339-103378077:+	BEX3	15;GO:0005123,molecular_function death receptor binding;GO:0005163,molecular_function nerve growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0042802,molecular_function identical protein binding;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043281,biological_process regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046872,molecular_function metal ion binding	NA	brain expressed X-linked 3 [Source:HGNC Symbol%3BAcc:HGNC:13388]
ENSG00000125304	86.64	87.30	84.55	80.86	83.77	82.44	0.0766645889155161	7.39091678560647	0.199253393940736	0.574157800861827	13:99501416-99564006:+	TM9SF2	7;GO:0005768,cellular_component endosome;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	transmembrane 9 superfamily member 2 [Source:HGNC Symbol%3BAcc:HGNC:11865]
ENSG00000038532	3.92	3.96	4.02	4.43	4.81	3.98	-0.138848417749525	3.8884070142088	0.199273938786574	0.574157800861827	16:10944487-11182189:+	CLEC16A	18;GO:0003674,molecular_function molecular_function;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0009267,biological_process cellular response to starvation;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0031982,cellular_component vesicle;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0036020,cellular_component endolysosome membrane;GO:1901097,biological_process negative regulation of autophagosome maturation;GO:1901098,biological_process positive regulation of autophagosome maturation;GO:1901525,biological_process negative regulation of macromitophagy;GO:1904263,biological_process positive regulation of TORC1 signaling;GO:1904766,biological_process negative regulation of macroautophagy by TORC1 signaling	NA	C-type lectin domain containing 16A [Source:HGNC Symbol%3BAcc:HGNC:29013]
ENSG00000080503	20.38	21.67	18.78	18.25	20.39	18.75	0.0940305344327133	6.67566146405976	0.199297611202933	0.574157800861827	9:1980289-2193624:+	SMARCA2	34;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000790,cellular_component nuclear chromatin;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007286,biological_process spermatid development;GO:0007399,biological_process nervous system development;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016514,cellular_component SWI/SNF complex;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0016887,molecular_function ATPase activity;GO:0030308,biological_process negative regulation of cell growth;GO:0042393,molecular_function histone binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex	SMARCA2_4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 [EC:3.6.4.-]; K11647	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 2 [Source:HGNC Symbol%3BAcc:HGNC:11098]
ENSG00000115841	1.47	2.03	2.34	2.19	2.61	2.18	-0.249750337544158	2.37365704938414	0.199310880843762	0.574157800861827	2:37923186-38067142:+	RMDN2	9;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	regulator of microtubule dynamics 2 [Source:HGNC Symbol%3BAcc:HGNC:26567]
ENSG00000166263	2.73	3.36	3.20	3.25	3.57	3.98	-0.217358420066316	2.5301224566202	0.199515887061842	0.574615013015926	17:54968726-55173632:+	STXBP4	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006605,biological_process protein targeting;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010838,biological_process positive regulation of keratinocyte proliferation;GO:0015758,biological_process glucose transport;GO:0019905,molecular_function syntaxin binding;GO:0050821,biological_process protein stabilization;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070062,cellular_component extracellular exosome;GO:1902808,biological_process positive regulation of cell cycle G1/S phase transition	NA	syntaxin binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:19694]
ENSG00000135414	3.59	4.77	3.86	2.94	3.91	3.51	0.231746072761066	2.23479691281783	0.199564928624382	0.57462293180572	12:55743279-55757278:+	GDF11	29;GO:0001501,biological_process skeletal system development;GO:0001656,biological_process metanephros development;GO:0001657,biological_process ureteric bud development;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0007399,biological_process nervous system development;GO:0007498,biological_process mesoderm development;GO:0008083,molecular_function growth factor activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0021512,biological_process spinal cord anterior/posterior patterning;GO:0031016,biological_process pancreas development;GO:0042981,biological_process regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043408,biological_process regulation of MAPK cascade;GO:0045596,biological_process negative regulation of cell differentiation;GO:0048468,biological_process cell development;GO:0048469,biological_process cell maturation;GO:0048593,biological_process camera-type eye morphogenesis;GO:0060021,biological_process palate development;GO:0060395,biological_process SMAD protein signal transduction	MSTN, GDF8; growth differentiation factor 8; K05497	growth differentiation factor 11 [Source:HGNC Symbol%3BAcc:HGNC:4216]
ENSG00000142541	2419.68	2270.91	2410.19	2295.60	2198.99	2303.72	0.0746422415590604	10.6289209171921	0.199647386305711	0.574725169921026	19:49487553-49492308:+	RPL13A	24;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015934,cellular_component large ribosomal subunit;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0071346,biological_process cellular response to interferon-gamma;GO:0097452,cellular_component GAIT complex;GO:1901194,biological_process negative regulation of formation of translation preinitiation complex	RP-L13Ae, RPL13A; large subunit ribosomal protein L13Ae; K02872	ribosomal protein L13a [Source:HGNC Symbol%3BAcc:HGNC:10304]
ENSG00000188428	16.72	20.84	21.57	21.05	21.84	23.60	-0.164435003594346	3.63709072224357	0.199693036161233	0.574725169921026	6:8013566-8064414:-	BLOC1S5	12;GO:0005515,molecular_function protein binding;GO:0008089,biological_process anterograde axonal transport;GO:0030133,cellular_component transport vesicle;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0032402,biological_process melanosome transport;GO:0032438,biological_process melanosome organization;GO:0035646,biological_process endosome to melanosome transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0050942,biological_process positive regulation of pigment cell differentiation;GO:1904115,cellular_component axon cytoplasm	NA	biogenesis of lysosomal organelles complex 1 subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:18561]
ENSG00000125871	23.37	23.53	23.76	27.55	23.73	25.49	-0.108174421021804	4.77787273455038	0.199786202261305	0.574860020553913	20:17968912-17991122:+	MGME1	12;GO:0000002,biological_process mitochondrial genome maintenance;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005739,cellular_component mitochondrion;GO:0006264,biological_process mitochondrial DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008297,molecular_function single-stranded DNA exodeoxyribonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0043504,biological_process mitochondrial DNA repair;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	mitochondrial genome maintenance exonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:16205]
ENSG00000182158	21.85	23.60	22.19	21.90	21.70	20.29	0.0914285560416494	5.47029357148724	0.200157451514102	0.575790669472732	7:137874978-138002067:-	CREB3L2	24;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002062,biological_process chondrocyte differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006986,biological_process response to unfolded protein;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035497,molecular_function cAMP response element binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051216,biological_process cartilage development	CREB3; cyclic AMP-responsive element-binding protein 3; K09048	cAMP responsive element binding protein 3 like 2 [Source:HGNC Symbol%3BAcc:HGNC:23720]
ENSG00000165102	12.33	12.49	13.38	11.00	12.37	12.42	0.106154952616837	4.86440003195632	0.200242161189992	0.575790669472732	8:43140454-43202855:+	HGSNAT	14;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0007041,biological_process lysosomal transport;GO:0015019,molecular_function heparan-alpha-glucosaminide N-acetyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0051259,biological_process protein oligomerization;GO:0070821,cellular_component tertiary granule membrane	HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [EC:2.3.1.78]; K10532	heparan-alpha-glucosaminide N-acetyltransferase [Source:HGNC Symbol%3BAcc:HGNC:26527]
ENSG00000118217	29.23	29.34	28.85	29.69	30.98	32.71	-0.0841927569958353	5.92536619407727	0.200248797237878	0.575790669472732	1:161766293-161964070:+	ATF6	41;GO:0000139,cellular_component Golgi membrane;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001654,biological_process eye development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006457,biological_process protein folding;GO:0006950,biological_process response to stress;GO:0006986,biological_process response to unfolded protein;GO:0006990,biological_process positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response;GO:0007165,biological_process signal transduction;GO:0007601,biological_process visual perception;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035497,molecular_function cAMP response element binding;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha; K09054	activating transcription factor 6 [Source:HGNC Symbol%3BAcc:HGNC:791]
ENSG00000164002	4.17	5.47	6.71	5.75	7.39	6.28	-0.239226099328081	2.77145736918608	0.200446591709751	0.5761033105236	1:40508740-40516556:+	EXO5	19;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006259,biological_process DNA metabolic process;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008310,molecular_function single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0036297,biological_process interstrand cross-link repair;GO:0042803,molecular_function protein homodimerization activity;GO:0045145,molecular_function single-stranded DNA 5'-3' exodeoxyribonuclease activity;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	exonuclease 5 [Source:HGNC Symbol%3BAcc:HGNC:26115]
ENSG00000166741	562.33	567.24	520.50	580.64	591.13	583.50	-0.0776362779915661	8.81347396510646	0.200464948264095	0.5761033105236	11:114257786-114313285:+	NNMT	11;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008112,molecular_function nicotinamide N-methyltransferase activity;GO:0008168,molecular_function methyltransferase activity;GO:0010243,biological_process response to organonitrogen compound;GO:0016740,molecular_function transferase activity;GO:0030760,molecular_function pyridine N-methyltransferase activity;GO:0031100,biological_process organ regeneration;GO:0032259,biological_process methylation;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0042493,biological_process response to drug	NNMT; nicotinamide N-methyltransferase [EC:2.1.1.1]; K00541	nicotinamide N-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:7861]
ENSG00000127220	9.15	8.48	9.43	10.12	10.09	9.80	-0.131677712170102	3.77645325819862	0.200496761577536	0.5761033105236	19:17292130-17310236:-	ABHD8	3;GO:0003824,molecular_function catalytic activity;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	abhydrolase domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:23759]
ENSG00000177076	0.94	0.81	1.16	1.63	1.29	1.28	-0.492774489694563	0.188632256642833	0.200564154074932	0.576163583552913	9:19409058-19452020:+	ACER2	21;GO:0000139,cellular_component Golgi membrane;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006672,biological_process ceramide metabolic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016811,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0017040,molecular_function ceramidase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030173,cellular_component integral component of Golgi membrane;GO:0032526,biological_process response to retinoic acid;GO:0033629,biological_process negative regulation of cell adhesion mediated by integrin;GO:0035690,biological_process cellular response to drug;GO:0046512,biological_process sphingosine biosynthetic process;GO:0071633,molecular_function dihydroceramidase activity;GO:0090285,biological_process negative regulation of protein glycosylation in Golgi	ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23]; K01441	alkaline ceramidase 2 [Source:HGNC Symbol%3BAcc:HGNC:23675]
ENSG00000135597	16.77	15.34	16.76	18.24	16.62	17.80	-0.0922804986369569	5.37705777261371	0.200723648005465	0.576271920105937	6:138903492-138988261:-	REPS1	10;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006898,biological_process receptor-mediated endocytosis;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0046872,molecular_function metal ion binding;GO:0061024,biological_process membrane organization	NA	RALBP1 associated Eps domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:15578]
ENSG00000174695	94.17	88.49	75.65	75.91	82.86	78.46	0.133679536328371	4.16812230646655	0.200756151090634	0.576271920105937	5:83052845-83077863:-	TMEM167A	7;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0009306,biological_process protein secretion;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046907,biological_process intracellular transport	NA	transmembrane protein 167A [Source:HGNC Symbol%3BAcc:HGNC:28330]
ENSG00000186020	6.75	6.31	7.62	5.89	5.57	7.17	0.16509449450462	3.65429082448802	0.200776682012064	0.576271920105937	19:36534773-36605276:-	ZNF529	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 529 [Source:HGNC Symbol%3BAcc:HGNC:29328]
ENSG00000104290	1.94	2.15	2.06	2.10	2.73	2.46	-0.237351169530474	2.21286004743097	0.20085476751922	0.576271920105937	8:28494204-28574268:+	FZD3	51;GO:0001736,biological_process establishment of planar polarity;GO:0001764,biological_process neuron migration;GO:0001843,biological_process neural tube closure;GO:0001942,biological_process hair follicle development;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0017147,molecular_function Wnt-protein binding;GO:0030165,molecular_function PDZ domain binding;GO:0030182,biological_process neuron differentiation;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030901,biological_process midbrain development;GO:0032433,cellular_component filopodium tip;GO:0033278,biological_process cell proliferation in midbrain;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0036342,biological_process post-anal tail morphogenesis;GO:0036514,biological_process dopaminergic neuron axon guidance;GO:0036515,biological_process serotonergic neuron axon guidance;GO:0042472,biological_process inner ear morphogenesis;GO:0042493,biological_process response to drug;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043025,cellular_component neuronal cell body;GO:0045177,cellular_component apical part of cell;GO:0045976,biological_process negative regulation of mitotic cell cycle, embryonic;GO:0048786,cellular_component presynaptic active zone;GO:0051602,biological_process response to electrical stimulus;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061549,biological_process sympathetic ganglion development;GO:0071679,biological_process commissural neuron axon guidance;GO:1900118,biological_process negative regulation of execution phase of apoptosis;GO:1904693,biological_process midbrain morphogenesis;GO:1904938,biological_process planar cell polarity pathway involved in axon guidance	FZD3; frizzled 3; K02329	frizzled class receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:4041]
ENSG00000198730	22.68	22.92	20.46	19.79	22.95	19.30	0.101484078240108	6.23393634155794	0.200876926632002	0.576271920105937	11:10750986-10779743:+	CTR9	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000993,molecular_function RNA polymerase II core binding;GO:0001711,biological_process endodermal cell fate commitment;GO:0001826,biological_process inner cell mass cell differentiation;GO:0001829,biological_process trophectodermal cell differentiation;GO:0001832,biological_process blastocyst growth;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0007259,biological_process JAK-STAT cascade;GO:0010390,biological_process histone monoubiquitination;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016570,biological_process histone modification;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0016607,cellular_component nuclear speck;GO:0019827,biological_process stem cell population maintenance;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0033523,biological_process histone H2B ubiquitination;GO:0035327,cellular_component transcriptionally active chromatin;GO:0042169,molecular_function SH2 domain binding;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0070102,biological_process interleukin-6-mediated signaling pathway;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0080182,biological_process histone H3-K4 trimethylation;GO:1900364,biological_process negative regulation of mRNA polyadenylation;GO:2000653,biological_process regulation of genetic imprinting;GO:2001162,biological_process positive regulation of histone H3-K79 methylation;GO:2001168,biological_process positive regulation of histone H2B ubiquitination	NA	CTR9 homolog%2C Paf1/RNA polymerase II complex component [Source:HGNC Symbol%3BAcc:HGNC:16850]
ENSG00000143569	61.19	68.89	64.60	61.55	65.18	57.40	0.0913727546168344	7.76216922049173	0.200880415556142	0.576271920105937	1:154220178-154271510:+	UBAP2L	8;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0005737,cellular_component cytoplasm;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0010628,biological_process positive regulation of gene expression;GO:0031519,cellular_component PcG protein complex;GO:0061484,biological_process hematopoietic stem cell homeostasis	NA	ubiquitin associated protein 2 like [Source:HGNC Symbol%3BAcc:HGNC:29877]
ENSG00000153774	60.32	64.84	57.92	64.68	66.64	64.49	-0.0882566282007786	6.00424967630675	0.2009521657519	0.576342914337934	16:75293697-75433485:-	CFDP1	13;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process;GO:0008360,biological_process regulation of cell shape;GO:0042127,biological_process regulation of cell proliferation;GO:2000270,biological_process negative regulation of fibroblast apoptotic process	NA	craniofacial development protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1873]
ENSG00000115289	20.45	19.31	20.65	18.40	17.86	19.64	0.125924873613114	3.92918275310221	0.20099802434294	0.576342914337934	2:74505042-74508580:-	PCGF1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008022,molecular_function protein C-terminus binding;GO:0031519,cellular_component PcG protein complex;GO:0035518,biological_process histone H2A monoubiquitination;GO:0046872,molecular_function metal ion binding	PCGF1, NSPC1; polycomb group RING finger protein 1; K11487	polycomb group ring finger 1 [Source:HGNC Symbol%3BAcc:HGNC:17615]
ENSG00000145623	119.80	108.78	121.82	109.07	106.00	117.83	0.0862082250697658	8.4936714185968	0.201059343569736	0.576385596242757	5:38845857-38945596:+	OSMR	12;GO:0002675,biological_process positive regulation of acute inflammatory response;GO:0004896,molecular_function cytokine receptor activity;GO:0004924,molecular_function oncostatin-M receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005900,cellular_component oncostatin-M receptor complex;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019838,molecular_function growth factor binding;GO:0034097,biological_process response to cytokine;GO:0038165,biological_process oncostatin-M-mediated signaling pathway	OSMR; oncostatin M receptor; K05057	oncostatin M receptor [Source:HGNC Symbol%3BAcc:HGNC:8507]
ENSG00000114026	19.86	18.44	18.99	20.30	20.60	20.73	-0.0905245663198699	5.13907261650512	0.201173080968806	0.576578493203831	3:9749943-9788219:+	OGG1	42;GO:0002526,biological_process acute inflammatory response;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003824,molecular_function catalytic activity;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007568,biological_process aging;GO:0008017,molecular_function microtubule binding;GO:0008152,biological_process metabolic process;GO:0008534,molecular_function oxidized purine nucleobase lesion DNA N-glycosylase activity;GO:0009314,biological_process response to radiation;GO:0009416,biological_process response to light stimulus;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016829,molecular_function lyase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0032355,biological_process response to estradiol;GO:0032357,molecular_function oxidized purine DNA binding;GO:0033158,biological_process regulation of protein import into nucleus, translocation;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034039,molecular_function 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045007,biological_process depurination;GO:0045008,biological_process depyrimidination;GO:0045471,biological_process response to ethanol;GO:0051593,biological_process response to folic acid;GO:0071276,biological_process cellular response to cadmium ion;GO:1901291,biological_process negative regulation of double-strand break repair via single-strand annealing	OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]; K03660	8-oxoguanine DNA glycosylase [Source:HGNC Symbol%3BAcc:HGNC:8125]
ENSG00000105974	426.91	449.23	434.65	411.99	434.55	405.39	0.077755174457263	8.34790755325804	0.201224389398914	0.576592415883823	7:116524784-116561184:+	CAV1	141;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000188,biological_process inactivation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0001570,biological_process vasculogenesis;GO:0001666,biological_process response to hypoxia;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0001960,biological_process negative regulation of cytokine-mediated signaling pathway;GO:0002026,biological_process regulation of the force of heart contraction;GO:0002080,cellular_component acrosomal membrane;GO:0002931,biological_process response to ischemia;GO:0003057,biological_process regulation of the force of heart contraction by chemical signal;GO:0005102,molecular_function receptor binding;GO:0005113,molecular_function patched binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0005925,cellular_component focal adhesion;GO:0005929,cellular_component cilium;GO:0005938,cellular_component cell cortex;GO:0006641,biological_process triglyceride metabolic process;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006940,biological_process regulation of smooth muscle contraction;GO:0007519,biological_process skeletal muscle tissue development;GO:0007595,biological_process lactation;GO:0008104,biological_process protein localization;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009617,biological_process response to bacterium;GO:0009968,biological_process negative regulation of signal transduction;GO:0010524,biological_process positive regulation of calcium ion transport into cytosol;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010952,biological_process positive regulation of peptidase activity;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016050,biological_process vesicle organization;GO:0016504,molecular_function peptidase activator activity;GO:0019065,biological_process receptor-mediated endocytosis of virus by host cell;GO:0019217,biological_process regulation of fatty acid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019915,biological_process lipid storage;GO:0030193,biological_process regulation of blood coagulation;GO:0030301,biological_process cholesterol transport;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030674,molecular_function protein binding, bridging;GO:0030857,biological_process negative regulation of epithelial cell differentiation;GO:0030879,biological_process mammary gland development;GO:0031295,biological_process T cell costimulation;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031623,biological_process receptor internalization;GO:0031901,cellular_component early endosome membrane;GO:0032091,biological_process negative regulation of protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032507,biological_process maintenance of protein location in cell;GO:0032570,biological_process response to progesterone;GO:0032947,molecular_function protein complex scaffold;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033484,biological_process nitric oxide homeostasis;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0034141,biological_process positive regulation of toll-like receptor 3 signaling pathway;GO:0042310,biological_process vasoconstriction;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0042632,biological_process cholesterol homeostasis;GO:0042802,molecular_function identical protein binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0043627,biological_process response to estrogen;GO:0044325,molecular_function ion channel binding;GO:0044860,biological_process protein localization to plasma membrane raft;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0045121,cellular_component membrane raft;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046982,molecular_function protein heterodimerization activity;GO:0048365,molecular_function Rac GTPase binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048550,biological_process negative regulation of pinocytosis;GO:0050900,biological_process leukocyte migration;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051001,biological_process negative regulation of nitric-oxide synthase activity;GO:0051117,molecular_function ATPase binding;GO:0051259,biological_process protein oligomerization;GO:0051260,biological_process protein homooligomerization;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0051592,biological_process response to calcium ion;GO:0051899,biological_process membrane depolarization;GO:0052547,biological_process regulation of peptidase activity;GO:0055074,biological_process calcium ion homeostasis;GO:0060056,biological_process mammary gland involution;GO:0060355,biological_process positive regulation of cell adhesion molecule production;GO:0060546,biological_process negative regulation of necroptotic process;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity;GO:0070320,molecular_function inward rectifier potassium channel inhibitor activity;GO:0070836,biological_process caveola assembly;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071455,biological_process cellular response to hyperoxia;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0072584,biological_process caveolin-mediated endocytosis;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0086098,biological_process angiotensin-activated signaling pathway involved in heart process;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097190,biological_process apoptotic signaling pathway;GO:0098903,biological_process regulation of membrane repolarization during action potential;GO:0098909,biological_process regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential;GO:1900027,biological_process regulation of ruffle assembly;GO:1900085,biological_process negative regulation of peptidyl-tyrosine autophosphorylation;GO:1901380,biological_process negative regulation of potassium ion transmembrane transport;GO:1901844,biological_process regulation of cell communication by electrical coupling involved in cardiac conduction;GO:1903071,biological_process positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1903361,biological_process protein localization to basolateral plasma membrane;GO:1903598,biological_process positive regulation of gap junction assembly;GO:1903609,biological_process negative regulation of inward rectifier potassium channel activity;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:2000286,biological_process receptor internalization involved in canonical Wnt signaling pathway;GO:2000535,biological_process regulation of entry of bacterium into host cell;GO:2000811,biological_process negative regulation of anoikis;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	CAV1; caveolin 1; K06278	caveolin 1 [Source:HGNC Symbol%3BAcc:HGNC:1527]
ENSG00000111450	20.24	20.49	20.24	18.43	19.25	19.27	0.108832941417566	4.3635985856112	0.201518105821593	0.577300772574066	12:130789599-130839266:-	STX2	28;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0007340,biological_process acrosome reaction;GO:0007398,biological_process ectoderm development;GO:0008021,cellular_component synaptic vesicle;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016323,cellular_component basolateral plasma membrane;GO:0030027,cellular_component lamellipodium;GO:0030154,biological_process cell differentiation;GO:0030193,biological_process regulation of blood coagulation;GO:0031201,cellular_component SNARE complex;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0033194,biological_process response to hydroperoxide;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046983,molecular_function protein dimerization activity;GO:0048278,biological_process vesicle docking;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome;GO:1903575,biological_process cornified envelope assembly	STX1B_2_3; syntaxin 1B/2/3; K08486	syntaxin 2 [Source:HGNC Symbol%3BAcc:HGNC:3403]
ENSG00000215788	4.63	4.39	5.85	4.20	4.04	4.77	0.210814688263248	2.7104818171581	0.201785610427963	0.577933729174506	1:6461150-6466195:-	TNFRSF25	19;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0097190,biological_process apoptotic signaling pathway	TNFRSF25; tumor necrosis factor receptor superfamily member 25; K05160	TNF receptor superfamily member 25 [Source:HGNC Symbol%3BAcc:HGNC:11910]
ENSG00000174606	14.80	16.75	16.87	15.28	14.03	15.73	0.111629563943798	4.67518778067392	0.201939338781938	0.578240602606734	1:212992181-213015826:-	ANGEL2	5;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005737,cellular_component cytoplasm;GO:0015030,cellular_component Cajal body;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization	NA	angel homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:30534]
ENSG00000048828	48.11	51.58	51.61	53.50	54.08	53.49	-0.0789887974814872	7.53114976091202	0.202072203478496	0.578487606498748	9:93451721-93566107:+	FAM120A	6;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	family with sequence similarity 120A [Source:HGNC Symbol%3BAcc:HGNC:13247]
ENSG00000213186	8.35	8.06	7.81	8.01	9.48	9.64	-0.151756089312675	3.5289352816294	0.202149207104199	0.578574615583221	3:160432444-160485773:-	TRIM59	17;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0030992,cellular_component intraciliary transport particle B;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	tripartite motif containing 59 [Source:HGNC Symbol%3BAcc:HGNC:30834]
ENSG00000099203	20.92	25.07	18.53	17.71	19.27	21.33	0.147503493884049	4.13401140350285	0.202428700081632	0.579221959171714	19:10832437-10836318:-	TMED1	15;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	transmembrane p24 trafficking protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17291]
ENSG00000182022	21.26	21.86	22.71	21.44	17.79	22.23	0.109326034627119	5.30388330205033	0.202468708680099	0.579221959171714	10:124007665-124093607:-	CHST15	9;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0019319,biological_process hexose biosynthetic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0050656,molecular_function 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0050659,molecular_function N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	CHST15; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase [EC:2.8.2.33]; K08106	carbohydrate sulfotransferase 15 [Source:HGNC Symbol%3BAcc:HGNC:18137]
ENSG00000001167	21.78	20.20	19.94	20.07	26.96	21.82	-0.138909116646496	4.51555661529575	0.202720032395854	0.579662853508926	6:41072944-41099976:+	NFYA	17;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016602,cellular_component CCAAT-binding factor complex;GO:0032993,cellular_component protein-DNA complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0090575,cellular_component RNA polymerase II transcription factor complex	NFYA; nuclear transcription factor Y, alpha; K08064	nuclear transcription factor Y subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:7804]
ENSG00000163960	17.14	15.18	16.46	17.81	16.23	19.32	-0.114483920331231	4.65565231400633	0.20275914624433	0.579662853508926	3:196347661-196432474:-	UBXN7	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0008134,molecular_function transcription factor binding;GO:0016604,cellular_component nuclear body;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0043130,molecular_function ubiquitin binding;GO:0043687,biological_process post-translational protein modification	NA	UBX domain protein 7 [Source:HGNC Symbol%3BAcc:HGNC:29119]
ENSG00000274349	1.96	2.01	2.23	1.53	2.11	1.80	0.202860058806767	2.6836706716714	0.202762918709076	0.579662853508926	9:66856425-66932141:+	ZNF658	12;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042254,biological_process ribosome biogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0071294,biological_process cellular response to zinc ion	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 658 [Source:HGNC Symbol%3BAcc:HGNC:25226]
ENSG00000116641	15.94	14.86	15.76	14.36	14.59	15.41	0.0828247465858553	6.71136235399288	0.203096090035626	0.580481640712003	1:62454297-62688368:-	DOCK7	24;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0005925,cellular_component focal adhesion;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0008180,cellular_component COP9 signalosome;GO:0022027,biological_process interkinetic nuclear migration;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031175,biological_process neuron projection development;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045178,cellular_component basal part of cell;GO:0045200,biological_process establishment of neuroblast polarity;GO:0048365,molecular_function Rac GTPase binding;GO:0050767,biological_process regulation of neurogenesis;GO:0090630,biological_process activation of GTPase activity;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration	NA	dedicator of cytokinesis 7 [Source:HGNC Symbol%3BAcc:HGNC:19190]
ENSG00000164970	18.09	19.01	19.95	18.67	17.05	16.57	0.137548743647984	3.75656523073593	0.203236355526479	0.580748821627575	9:34398183-34458570:-	FAM219A	NA	NA	family with sequence similarity 219 member A [Source:HGNC Symbol%3BAcc:HGNC:19920]
ENSG00000196792	24.81	25.38	25.83	24.58	24.20	23.65	0.081428039451503	5.89057412291463	0.203357571310542	0.580905336921649	14:30893798-31026401:-	STRN3	17;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030425,cellular_component dendrite;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070016,molecular_function armadillo repeat domain binding	NA	striatin 3 [Source:HGNC Symbol%3BAcc:HGNC:15720]
ENSG00000113595	4.77	5.13	5.39	5.10	5.17	7.42	-0.20335006992636	3.32626605482997	0.203384725228509	0.580905336921649	5:65589679-65625975:-	TRIM23	26;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003924,molecular_function GTPase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008047,molecular_function enzyme activator activity;GO:0008270,molecular_function zinc ion binding;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019003,molecular_function GDP binding;GO:0042802,molecular_function identical protein binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	tripartite motif containing 23 [Source:HGNC Symbol%3BAcc:HGNC:660]
ENSG00000100934	86.58	94.92	81.25	81.71	86.44	80.58	0.0898731835381078	7.6640905624392	0.203577758540575	0.581077003803375	14:39031918-39109646:-	SEC23A	24;GO:0000139,cellular_component Golgi membrane;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008270,molecular_function zinc ion binding;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019898,cellular_component extrinsic component of membrane;GO:0030127,cellular_component COPII vesicle coat;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030868,cellular_component smooth endoplasmic reticulum membrane;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070971,cellular_component endoplasmic reticulum exit site;GO:0090110,biological_process cargo loading into COPII-coated vesicle	SEC23; protein transport protein SEC23; K14006	Sec23 homolog A%2C coat complex II component [Source:HGNC Symbol%3BAcc:HGNC:10701]
ENSG00000241360	5.41	3.87	5.30	3.88	4.01	4.59	0.252834126783956	2.06649245181785	0.203609396650667	0.581077003803375	22:37658726-37666934:+	PDXP	33;GO:0000287,molecular_function magnesium ion binding;GO:0004647,molecular_function phosphoserine phosphatase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008152,biological_process metabolic process;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030027,cellular_component lamellipodium;GO:0030496,cellular_component midbody;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0031072,molecular_function heat shock protein binding;GO:0031247,biological_process actin rod assembly;GO:0031258,cellular_component lamellipodium membrane;GO:0032154,cellular_component cleavage furrow;GO:0032361,biological_process pyridoxal phosphate catabolic process;GO:0032465,biological_process regulation of cytokinesis;GO:0032587,cellular_component ruffle membrane;GO:0033883,molecular_function pyridoxal phosphatase activity;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070938,cellular_component contractile ring;GO:0071318,biological_process cellular response to ATP;GO:0098519,molecular_function nucleotide phosphatase activity, acting on free nucleotides	PDXP; pyridoxal phosphatase [EC:3.1.3.74]; K07758	pyridoxal phosphatase [Source:HGNC Symbol%3BAcc:HGNC:30259]
ENSG00000157106	14.59	13.65	15.09	15.88	14.36	16.20	-0.0872961009240694	7.38774312126908	0.203610518998334	0.581077003803375	16:18804852-18926454:-	SMG1	25;GO:0000166,molecular_function nucleotide binding;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006406,biological_process mRNA export from nucleus;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032204,biological_process regulation of telomere maintenance;GO:0042162,molecular_function telomeric DNA binding;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046872,molecular_function metal ion binding	SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1]; K08873	SMG1%2C nonsense mediated mRNA decay associated PI3K related kinase [Source:HGNC Symbol%3BAcc:HGNC:30045]
ENSG00000205903	12.22	13.14	11.17	11.04	11.68	11.53	0.0993156015946703	5.15515544341473	0.203632076576547	0.581077003803375	7:6637321-6656432:+	ZNF316	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 316 [Source:HGNC Symbol%3BAcc:HGNC:13843]
ENSG00000108465	84.85	82.03	86.85	82.85	76.08	82.90	0.0815460138372501	7.30105177382289	0.203955932679991	0.581826828977465	17:47967809-47981774:+	CDK5RAP3	38;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0007420,biological_process brain development;GO:0008283,biological_process cell proliferation;GO:0010921,biological_process regulation of phosphatase activity;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030262,biological_process apoptotic nuclear changes;GO:0030332,molecular_function cyclin binding;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0043234,cellular_component protein complex;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0044387,biological_process negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0044818,biological_process mitotic G2/M transition checkpoint;GO:0045664,biological_process regulation of neuron differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051059,molecular_function NF-kappaB binding;GO:0071569,biological_process protein ufmylation;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0097371,molecular_function MDM2/MDM4 family protein binding;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901798,biological_process positive regulation of signal transduction by p53 class mediator;GO:1903363,biological_process negative regulation of cellular protein catabolic process	NA	CDK5 regulatory subunit associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:18673]
ENSG00000156869	5.23	5.39	5.76	5.06	4.60	5.17	0.153792375949823	3.31053547915651	0.204069290070732	0.581826828977465	1:99708702-99766631:-	FRRS1	6;GO:0000293,molecular_function ferric-chelate reductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	ferric chelate reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:27622]
ENSG00000133111	6.92	6.56	6.40	5.69	3.90	7.15	0.255020116319618	2.36210631466984	0.204073021745939	0.581826828977465	13:36819223-36829104:+	RFXAP	6;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0016607,cellular_component nuclear speck;GO:0045893,biological_process positive regulation of transcription, DNA-templated	RFXAP; regulatory factor X-associated protein; K08063	regulatory factor X associated protein [Source:HGNC Symbol%3BAcc:HGNC:9988]
ENSG00000174276	5.37	4.98	4.14	4.21	4.27	4.19	0.205013601533112	2.48905560399544	0.20419120142218	0.581826828977465	11:65116402-65117708:-	ZNHIT2	2;GO:0022008,biological_process neurogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger HIT-type containing 2 [Source:HGNC Symbol%3BAcc:HGNC:1177]
ENSG00000102996	3.74	2.93	3.37	3.36	5.19	3.39	-0.228129356541463	2.99036665262699	0.204249251121244	0.581826828977465	16:58025565-58046901:+	MMP15	21;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0008047,molecular_function enzyme activator activity;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0032355,biological_process response to estradiol;GO:0035987,biological_process endodermal cell differentiation;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity	MMP15; matrix metalloproteinase-15 (membrane-inserted) [EC:3.4.24.-]; K07995	matrix metallopeptidase 15 [Source:HGNC Symbol%3BAcc:HGNC:7161]
ENSG00000125772	9.15	6.44	7.53	8.79	8.42	8.73	-0.143109265708898	4.09735556265188	0.204265901944081	0.581826828977465	20:5544403-5611026:-	GPCPD1	12;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0007519,biological_process skeletal muscle tissue development;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008889,molecular_function glycerophosphodiester phosphodiesterase activity;GO:0016787,molecular_function hydrolase activity;GO:0030246,molecular_function carbohydrate binding;GO:0030643,biological_process cellular phosphate ion homeostasis;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0047389,molecular_function glycerophosphocholine phosphodiesterase activity;GO:2001070,molecular_function starch binding	NA	glycerophosphocholine phosphodiesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:26957]
ENSG00000022840	59.11	62.37	59.43	63.13	67.38	62.39	-0.081530323006503	7.33173407000099	0.204301844704534	0.581826828977465	12:120533479-120577594:+	RNF10	14;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010626,biological_process negative regulation of Schwann cell proliferation;GO:0031643,biological_process positive regulation of myelination;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination	NA	ring finger protein 10 [Source:HGNC Symbol%3BAcc:HGNC:10055]
ENSG00000167522	24.60	24.75	26.94	27.65	26.05	27.72	-0.081918158768333	7.75844899060214	0.204305917590606	0.581826828977465	16:89267626-89490561:-	ANKRD11	12;GO:0001701,biological_process in utero embryonic development;GO:0001894,biological_process tissue homeostasis;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0035264,biological_process multicellular organism growth;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0048705,biological_process skeletal system morphogenesis;GO:0060323,biological_process head morphogenesis;GO:0060325,biological_process face morphogenesis;GO:0060348,biological_process bone development	NA	ankyrin repeat domain 11 [Source:HGNC Symbol%3BAcc:HGNC:21316]
ENSG00000171234	0.62	1.39	0.97	1.04	0.67	0.44	0.451835975835699	0.557309523935979	0.204316696005218	0.581826828977465	4:69051362-69112987:+	UGT2B7	16;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008209,biological_process androgen metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0052695,biological_process cellular glucuronidation;GO:0070062,cellular_component extracellular exosome	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 2 member B7 [Source:HGNC Symbol%3BAcc:HGNC:12554]
ENSG00000124813	20.16	19.62	20.41	21.78	19.59	23.64	-0.0994024753876646	5.53225454089662	0.20441891505714	0.581984401973458	6:45328156-45664349:+	RUNX2	55;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001649,biological_process osteoblast differentiation;GO:0001958,biological_process endochondral ossification;GO:0002051,biological_process osteoblast fate commitment;GO:0002062,biological_process chondrocyte differentiation;GO:0002063,biological_process chondrocyte development;GO:0002076,biological_process osteoblast development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0019904,molecular_function protein domain specific binding;GO:0030097,biological_process hemopoiesis;GO:0030182,biological_process neuron differentiation;GO:0030217,biological_process T cell differentiation;GO:0030278,biological_process regulation of ossification;GO:0030509,biological_process BMP signaling pathway;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0040036,biological_process regulation of fibroblast growth factor receptor signaling pathway;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042487,biological_process regulation of odontogenesis of dentin-containing tooth;GO:0043425,molecular_function bHLH transcription factor binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045595,biological_process regulation of cell differentiation;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048469,biological_process cell maturation;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0048863,biological_process stem cell differentiation;GO:0070491,molecular_function repressing transcription factor binding;GO:0071773,biological_process cellular response to BMP stimulus;GO:1901522,biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	RUNX2, AML3; runt-related transcription factor 2; K09278	runt related transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:10472]
ENSG00000126705	11.37	10.63	12.12	10.51	10.46	11.35	0.0928163032938396	5.7407112593069	0.204626951998376	0.582443099095584	1:27534034-27604431:-	AHDC1	1;GO:0003677,molecular_function DNA binding	NA	AT-hook DNA binding motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25230]
ENSG00000196482	0.51	0.87	0.62	0.58	1.43	0.78	-0.493427768609096	0.452744927033806	0.204790844644448	0.582775963909108	1:216503245-217137755:-	ESRRG	21;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003708,molecular_function retinoic acid receptor activity;GO:0005496,molecular_function steroid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0050682,molecular_function AF-2 domain binding	NA	estrogen related receptor gamma [Source:HGNC Symbol%3BAcc:HGNC:3474]
ENSG00000021826	14.24	17.73	14.58	15.36	18.60	16.87	-0.118651543283316	6.19808090504098	0.205000076558777	0.58323766910935	2:210477681-210679107:+	CPS1	59;GO:0000050,biological_process urea cycle;GO:0000166,molecular_function nucleotide binding;GO:0001889,biological_process liver development;GO:0003824,molecular_function catalytic activity;GO:0004087,molecular_function carbamoyl-phosphate synthase (ammonia) activity;GO:0004088,molecular_function carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004175,molecular_function endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006207,biological_process 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006508,biological_process proteolysis;GO:0006526,biological_process arginine biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0006807,biological_process nitrogen compound metabolic process;GO:0007494,biological_process midgut development;GO:0008152,biological_process metabolic process;GO:0009636,biological_process response to toxic substance;GO:0010043,biological_process response to zinc ion;GO:0014075,biological_process response to amine;GO:0016595,molecular_function glutamate binding;GO:0016874,molecular_function ligase activity;GO:0019240,biological_process citrulline biosynthetic process;GO:0019433,biological_process triglyceride catabolic process;GO:0032094,biological_process response to food;GO:0032403,molecular_function protein complex binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0033762,biological_process response to glucagon;GO:0034201,biological_process response to oleic acid;GO:0042311,biological_process vasodilation;GO:0042493,biological_process response to drug;GO:0042594,biological_process response to starvation;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043200,biological_process response to amino acid;GO:0043234,cellular_component protein complex;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0046209,biological_process nitric oxide metabolic process;GO:0046872,molecular_function metal ion binding;GO:0048545,biological_process response to steroid hormone;GO:0050667,biological_process homocysteine metabolic process;GO:0051384,biological_process response to glucocorticoid;GO:0051591,biological_process response to cAMP;GO:0055081,biological_process anion homeostasis;GO:0060416,biological_process response to growth hormone;GO:0070365,biological_process hepatocyte differentiation;GO:0070409,biological_process carbamoyl phosphate biosynthetic process;GO:0071320,biological_process cellular response to cAMP;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0071400,biological_process cellular response to oleic acid;GO:0071548,biological_process response to dexamethasone;GO:0072341,molecular_function modified amino acid binding;GO:1903718,biological_process cellular response to ammonia	CPS1; carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16]; K01948	carbamoyl-phosphate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:2323]
ENSG00000198677	17.10	17.94	19.17	15.56	17.81	17.83	0.0939749916599247	6.36856380734106	0.205130943643009	0.583345373127066	5:95463894-95555007:-	TTC37	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0035327,cellular_component transcriptionally active chromatin;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0055087,cellular_component Ski complex	SKI3, TTC37; superkiller protein 3; K12600	tetratricopeptide repeat domain 37 [Source:HGNC Symbol%3BAcc:HGNC:23639]
ENSG00000139154	17.28	19.18	17.67	16.18	16.61	17.93	0.100062669651019	4.93947099985102	0.205131922476407	0.583345373127066	12:19404044-19720801:+	AEBP2	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0035098,cellular_component ESC/E(Z) complex;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding	NA	AE binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:24051]
ENSG00000121406	5.00	4.98	5.39	4.24	5.15	4.50	0.16263185920182	3.33090141942571	0.205456968589912	0.584118904488961	19:57527324-57557542:+	ZNF549	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 549 [Source:HGNC Symbol%3BAcc:HGNC:26632]
ENSG00000177030	21.81	19.63	20.80	21.68	22.57	22.66	-0.0888191456297116	5.33535690482333	0.205498046878538	0.584118904488961	11:644232-706715:-	DEAF1	27;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0001662,biological_process behavioral fear response;GO:0001843,biological_process neural tube closure;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007281,biological_process germ cell development;GO:0007399,biological_process nervous system development;GO:0008542,biological_process visual learning;GO:0009653,biological_process anatomical structure morphogenesis;GO:0033599,biological_process regulation of mammary gland epithelial cell proliferation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048706,biological_process embryonic skeletal system development	NA	DEAF1%2C transcription factor [Source:HGNC Symbol%3BAcc:HGNC:14677]
ENSG00000166313	3.94	3.79	4.04	4.11	4.84	4.31	-0.155208055136411	3.32936330760529	0.205634987054667	0.584303507892063	11:6395123-6419414:-	APBB1	47;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001540,molecular_function beta-amyloid binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006302,biological_process double-strand break repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007409,biological_process axonogenesis;GO:0008134,molecular_function transcription factor binding;GO:0010039,biological_process response to iron ion;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0030027,cellular_component lamellipodium;GO:0030308,biological_process negative regulation of cell growth;GO:0030426,cellular_component growth cone;GO:0032403,molecular_function protein complex binding;GO:0042393,molecular_function histone binding;GO:0042734,cellular_component presynaptic membrane;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0043234,cellular_component protein complex;GO:0043967,biological_process histone H4 acetylation;GO:0044304,cellular_component main axon;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045739,biological_process positive regulation of DNA repair;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048156,molecular_function tau protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050714,biological_process positive regulation of protein secretion;GO:0050760,biological_process negative regulation of thymidylate synthase biosynthetic process;GO:0070064,molecular_function proline-rich region binding;GO:1990761,cellular_component growth cone lamellipodium;GO:1990812,cellular_component growth cone filopodium	APBB1, FE65; amyloid beta A4 precursor protein-binding family B member 1; K04529	amyloid beta precursor protein binding family B member 1 [Source:HGNC Symbol%3BAcc:HGNC:581]
ENSG00000155755	19.15	21.90	18.91	20.84	21.53	22.75	-0.115088730034731	4.72381425909665	0.205674582445068	0.584303507892063	2:201620183-201643570:-	TMEM237	8;GO:0005929,cellular_component cilium;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0035869,cellular_component ciliary transition zone;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	transmembrane protein 237 [Source:HGNC Symbol%3BAcc:HGNC:14432]
ENSG00000172366	24.78	19.19	18.81	25.51	22.31	23.53	-0.164981554951971	3.48907440731931	0.205704207644269	0.584303507892063	16:636816-648474:+	MCRIP2	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0010494,cellular_component cytoplasmic stress granule	NA	MAPK regulated corepressor interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:14142]
ENSG00000167525	5.48	5.20	5.18	6.35	5.34	6.47	-0.18316984411826	2.86091183690409	0.205858979173615	0.584609359067052	17:28703196-28711854:-	PROCA1	3;GO:0004623,molecular_function phospholipase A2 activity;GO:0006644,biological_process phospholipid metabolic process;GO:0050482,biological_process arachidonic acid secretion	NA	protein interacting with cyclin A1 [Source:HGNC Symbol%3BAcc:HGNC:28600]
ENSG00000160999	5.48	4.15	3.93	5.18	5.77	4.69	-0.185149875075189	3.32838116979095	0.206034375749187	0.584973629042694	7:102285090-102321711:+	SH2B2	22;GO:0001725,cellular_component stress fiber;GO:0001726,cellular_component ruffle;GO:0001922,biological_process B-1 B cell homeostasis;GO:0004871,molecular_function signal transducer activity;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009967,biological_process positive regulation of signal transduction;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019222,biological_process regulation of metabolic process;GO:0030036,biological_process actin cytoskeleton organization;GO:0035556,biological_process intracellular signal transduction;GO:0035591,molecular_function signaling adaptor activity;GO:0042802,molecular_function identical protein binding;GO:0046578,biological_process regulation of Ras protein signal transduction;GO:0050776,biological_process regulation of immune response;GO:0050851,biological_process antigen receptor-mediated signaling pathway;GO:0050873,biological_process brown fat cell differentiation	APS, SH2B2; SH2B adapter protein 2; K07193	SH2B adaptor protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17381]
ENSG00000225921	83.98	78.71	81.63	95.30	76.80	92.45	-0.10229360975042	6.06790290941105	0.206147651073357	0.585161397844404	6:13615326-13632739:+	NOL7	4;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion	NA	nucleolar protein 7 [Source:HGNC Symbol%3BAcc:HGNC:21040]
ENSG00000146463	22.52	21.46	22.96	24.09	22.85	24.51	-0.0810254337051836	6.74674712538539	0.206243445644176	0.585299472057877	1:35268966-35422058:+	ZMYM4	11;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0022604,biological_process regulation of cell morphogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger MYM-type containing 4 [Source:HGNC Symbol%3BAcc:HGNC:13055]
ENSG00000171858	362.93	294.93	324.69	356.09	321.70	390.45	-0.107539824676684	7.1622474031244	0.206291432638181	0.585301840762911	20:62387115-62388520:+	RPS21	19;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000461,biological_process endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0047485,molecular_function protein N-terminus binding	RP-S21e, RPS21; small subunit ribosomal protein S21e; K02971	ribosomal protein S21 [Source:HGNC Symbol%3BAcc:HGNC:10409]
ENSG00000134970	20.18	22.04	18.51	19.28	17.49	18.63	0.136407925655798	3.71364192621983	0.206348620765796	0.585330308401698	5:115613507-115632992:-	TMED7	19;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030126,cellular_component COPI vesicle coat;GO:0030127,cellular_component COPII vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,cellular_component extracellular exosome	NA	transmembrane p24 trafficking protein 7 [Source:HGNC Symbol%3BAcc:HGNC:24253]
ENSG00000073711	21.93	21.41	21.52	22.49	23.45	23.13	-0.0783318514014207	6.3491455831363	0.206465352234524	0.585527625608214	3:135965672-136147891:+	PPP2R3A	8;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0006470,biological_process protein dephosphorylation;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0046872,molecular_function metal ion binding;GO:0050790,biological_process regulation of catalytic activity;GO:0061053,biological_process somite development	PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''; K11583	protein phosphatase 2 regulatory subunit B''alpha [Source:HGNC Symbol%3BAcc:HGNC:9307]
ENSG00000126067	147.69	152.30	132.31	148.50	167.53	149.62	-0.0967027119139852	6.49849643196828	0.206552538946744	0.585587036277765	1:35599543-35641844:-	PSMB2	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010243,biological_process response to organonitrogen compound;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMB2; 20S proteasome subunit beta 4 [EC:3.4.25.1]; K02734	proteasome subunit beta 2 [Source:HGNC Symbol%3BAcc:HGNC:9539]
ENSG00000141994	9.53	9.41	11.33	12.20	10.75	10.44	-0.126124169132351	4.56745533507372	0.206580651885953	0.585587036277765	19:5784831-5791238:-	DUS3L	9;GO:0002943,biological_process tRNA dihydrouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0008033,biological_process tRNA processing;GO:0016491,molecular_function oxidoreductase activity;GO:0017150,molecular_function tRNA dihydrouridine synthase activity;GO:0046872,molecular_function metal ion binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	dihydrouridine synthase 3 like [Source:HGNC Symbol%3BAcc:HGNC:26920]
ENSG00000165669	34.52	32.37	29.59	33.63	31.99	40.66	-0.129133803640133	4.77850395905776	0.206729368023041	0.585874804856166	10:118297929-118342328:-	FAM204A	NA	NA	family with sequence similarity 204 member A [Source:HGNC Symbol%3BAcc:HGNC:25794]
ENSG00000179295	31.59	32.36	29.72	31.45	34.75	34.05	-0.0881085874954339	5.89836043557378	0.206994849575122	0.586255226121228	12:112418350-112509913:+	PTPN11	85;GO:0000077,biological_process DNA damage checkpoint;GO:0000187,biological_process activation of MAPK activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0009967,biological_process positive regulation of signal transduction;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019904,molecular_function protein domain specific binding;GO:0021697,biological_process cerebellar cortex formation;GO:0030168,biological_process platelet activation;GO:0030220,biological_process platelet formation;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031295,biological_process T cell costimulation;GO:0031748,molecular_function D1 dopamine receptor binding;GO:0032528,biological_process microvillus organization;GO:0033277,biological_process abortive mitotic cell cycle;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0033629,biological_process negative regulation of cell adhesion mediated by integrin;GO:0035264,biological_process multicellular organism growth;GO:0035265,biological_process organ growth;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035855,biological_process megakaryocyte development;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0036302,biological_process atrioventricular canal development;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038127,biological_process ERBB signaling pathway;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042445,biological_process hormone metabolic process;GO:0042593,biological_process glucose homeostasis;GO:0043234,cellular_component protein complex;GO:0043254,biological_process regulation of protein complex assembly;GO:0043274,molecular_function phospholipase binding;GO:0043560,molecular_function insulin receptor substrate binding;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046825,biological_process regulation of protein export from nucleus;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046887,biological_process positive regulation of hormone secretion;GO:0046888,biological_process negative regulation of hormone secretion;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048609,biological_process multicellular organismal reproductive process;GO:0048806,biological_process genitalia development;GO:0048839,biological_process inner ear development;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0051428,molecular_function peptide hormone receptor binding;GO:0051463,biological_process negative regulation of cortisol secretion;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060125,biological_process negative regulation of growth hormone secretion;GO:0060325,biological_process face morphogenesis;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0061582,biological_process intestinal epithelial cell migration;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:1990782,molecular_function protein tyrosine kinase binding;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]; K07293	protein tyrosine phosphatase%2C non-receptor type 11 [Source:HGNC Symbol%3BAcc:HGNC:9644]
ENSG00000173960	25.18	25.46	25.39	29.87	24.30	29.32	-0.12518808132543	4.38156110883212	0.207038961574893	0.586255226121228	2:23927284-24004909:+	UBXN2A	18;GO:0000045,biological_process autophagosome assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005801,cellular_component cis-Golgi network;GO:0005829,cellular_component cytosol;GO:0007030,biological_process Golgi organization;GO:0010468,biological_process regulation of gene expression;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031468,biological_process nuclear envelope reassembly;GO:0033130,molecular_function acetylcholine receptor binding;GO:0042176,biological_process regulation of protein catabolic process;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050790,biological_process regulation of catalytic activity;GO:0061025,biological_process membrane fusion;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	UBX domain protein 2A [Source:HGNC Symbol%3BAcc:HGNC:27265]
ENSG00000142794	5.32	4.80	4.82	5.71	5.04	6.02	-0.153611968423939	3.45015486392395	0.207161744318793	0.586255226121228	1:21440127-21485005:+	NBPF3	2;GO:0005737,cellular_component cytoplasm;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	NBPF member 3 [Source:HGNC Symbol%3BAcc:HGNC:25076]
ENSG00000226742	40.48	38.39	35.11	36.65	29.83	35.60	0.168958715806736	3.13013651344875	0.207220466846417	0.586255226121228	18:79964560-79970822:+	HSBP1L1	2;GO:0003714,molecular_function transcription corepressor activity;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	heat shock factor binding protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:37243]
ENSG00000099290	18.36	20.59	18.38	18.33	19.12	16.59	0.0950634718549998	6.2395267527144	0.20728491220187	0.586255226121228	10:50067887-50133506:+	WASHC2A	13;GO:0005730,cellular_component nucleolus;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0031901,cellular_component early endosome membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0071203,cellular_component WASH complex	NA	WASH complex subunit 2A [Source:HGNC Symbol%3BAcc:HGNC:23416]
ENSG00000126749	6.95	6.27	3.82	4.30	5.18	4.51	0.291009133840949	1.9697495202654	0.20732476902522	0.586255226121228	12:6970892-6979941:+	EMG1	17;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0019843,molecular_function rRNA binding;GO:0032040,cellular_component small-subunit processome;GO:0032259,biological_process methylation;GO:0042254,biological_process ribosome biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0070037,molecular_function rRNA (pseudouridine) methyltransferase activity;GO:0070475,biological_process rRNA base methylation	EMG1, NEP1; rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260]; K14568	NA
ENSG00000167674	36.71	35.32	31.85	36.21	38.78	36.49	-0.0902718301072519	6.39755727768012	0.207358375794736	0.586255226121228	19:4472286-4502211:+	HDGFL2	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0030307,biological_process positive regulation of cell growth	NA	HDGF like 2 [Source:HGNC Symbol%3BAcc:HGNC:14680]
ENSG00000151364	10.25	13.37	12.60	12.53	13.28	15.26	-0.181211068065036	3.32165184428274	0.207437831000609	0.586255226121228	11:78015714-78046191:-	KCTD14	2;GO:0005515,molecular_function protein binding;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 14 [Source:HGNC Symbol%3BAcc:HGNC:23295]
ENSG00000089682	10.37	8.84	9.95	9.78	10.15	12.69	-0.146250902217404	4.01383937502706	0.207488993894795	0.586255226121228	X:107064419-107118823:-	RBM41	8;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0030626,molecular_function U12 snRNA binding;GO:0032502,biological_process developmental process;GO:0097157,molecular_function pre-mRNA intronic binding	NA	RNA binding motif protein 41 [Source:HGNC Symbol%3BAcc:HGNC:25617]
ENSG00000011132	7.66	7.87	8.15	7.07	7.52	7.17	0.132784489803876	3.72335227252317	0.207528452312155	0.586255226121228	19:3750818-3761699:-	APBA3	13;GO:0001540,molecular_function beta-amyloid binding;GO:0001701,biological_process in utero embryonic development;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0007268,biological_process chemical synaptic transmission;GO:0010468,biological_process regulation of gene expression;GO:0015031,biological_process protein transport;GO:0019899,molecular_function enzyme binding;GO:0043086,biological_process negative regulation of catalytic activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050790,biological_process regulation of catalytic activity	NA	amyloid beta precursor protein binding family A member 3 [Source:HGNC Symbol%3BAcc:HGNC:580]
ENSG00000174529	2.12	4.12	2.79	1.57	2.48	2.85	0.364595625492612	1.1001054397248	0.207533601435874	0.586255226121228	1:205083128-205084460:-	TMEM81	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 81 [Source:HGNC Symbol%3BAcc:HGNC:32349]
ENSG00000248905	2.39	2.05	2.36	2.27	1.97	1.99	0.145083220646535	3.72424981328949	0.207571065109807	0.586255226121228	15:32765544-33194733:-	FMN1	23;GO:0001822,biological_process kidney development;GO:0003779,molecular_function actin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0008017,molecular_function microtubule binding;GO:0010467,biological_process gene expression;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030054,cellular_component cell junction;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0035136,biological_process forelimb morphogenesis;GO:0035137,biological_process hindlimb morphogenesis;GO:0045010,biological_process actin nucleation;GO:0048705,biological_process skeletal system morphogenesis;GO:0048813,biological_process dendrite morphogenesis;GO:0051127,biological_process positive regulation of actin nucleation;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0060173,biological_process limb development;GO:0072092,biological_process ureteric bud invasion	NA	formin 1 [Source:HGNC Symbol%3BAcc:HGNC:3768]
ENSG00000175183	37.07	35.91	33.47	29.57	38.26	30.19	0.131652208860282	4.74864327200366	0.207603250289428	0.586255226121228	12:76858714-76879060:-	CSRP2	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005925,cellular_component focal adhesion;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0046872,molecular_function metal ion binding	NA	cysteine and glycine rich protein 2 [Source:HGNC Symbol%3BAcc:HGNC:2470]
ENSG00000051108	120.61	121.21	117.98	106.28	120.11	116.13	0.0826101026898684	7.24835158049524	0.207603531477521	0.586255226121228	16:56932047-56944863:+	HERPUD1	25;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0031396,biological_process regulation of protein ubiquitination;GO:0032092,biological_process positive regulation of protein binding;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0034704,cellular_component calcium channel complex;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044325,molecular_function ion channel binding;GO:1902235,biological_process regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903069,biological_process regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1903071,biological_process positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1990037,cellular_component Lewy body core;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	HERPUD1, HERP; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; K14027	homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol%3BAcc:HGNC:13744]
ENSG00000102225	75.69	72.79	73.74	78.66	77.52	79.90	-0.0750830352428427	7.31225115995673	0.207610128548395	0.586255226121228	X:47217859-47229997:+	CDK16	27;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006887,biological_process exocytosis;GO:0007283,biological_process spermatogenesis;GO:0008021,cellular_component synaptic vesicle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0030133,cellular_component transport vesicle;GO:0030154,biological_process cell differentiation;GO:0030252,biological_process growth hormone secretion;GO:0031175,biological_process neuron projection development;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus	NA	cyclin dependent kinase 16 [Source:HGNC Symbol%3BAcc:HGNC:8749]
ENSG00000132031	1.60	1.90	1.92	2.67	2.18	1.83	-0.294473009175832	1.62829658381974	0.207706543232819	0.586255226121228	2:19992110-20012694:-	MATN3	10;GO:0001501,biological_process skeletal system development;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0030198,biological_process extracellular matrix organization;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process	NA	matrilin 3 [Source:HGNC Symbol%3BAcc:HGNC:6909]
ENSG00000120071	15.93	14.43	16.16	16.02	17.45	16.52	-0.0877259791558403	5.75322682570163	0.207834441081036	0.586255226121228	17:46029915-46225389:-	KANSL1	16;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0016569,biological_process covalent chromatin modification;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific);GO:0071339,cellular_component MLL1 complex	NA	KAT8 regulatory NSL complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:24565]
ENSG00000130830	29.94	31.53	29.37	31.56	33.62	31.94	-0.0870496611881206	5.69540518126624	0.207844021034768	0.586255226121228	X:154778683-154821007:-	MPP1	12;GO:0004385,molecular_function guanylate kinase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0030863,cellular_component cortical cytoskeleton;GO:0032420,cellular_component stereocilium;GO:0042995,cellular_component cell projection;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0090022,biological_process regulation of neutrophil chemotaxis	NA	membrane palmitoylated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7219]
ENSG00000114745	11.74	12.34	12.71	12.11	10.67	11.37	0.117441830541373	4.22005906266049	0.207854226269102	0.586255226121228	3:39096658-39108363:-	GORASP1	13;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006487,biological_process protein N-linked glycosylation;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0048208,biological_process COPII vesicle coating;GO:0050774,biological_process negative regulation of dendrite morphogenesis;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	NA	golgi reassembly stacking protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16769]
ENSG00000198093	3.26	4.03	3.15	4.00	4.55	3.57	-0.214311572968019	2.5441801167947	0.20787802352559	0.586255226121228	19:51889223-51905040:-	ZNF649	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 649 [Source:HGNC Symbol%3BAcc:HGNC:25741]
ENSG00000187325	16.88	18.53	16.52	16.80	19.54	21.67	-0.155092568376989	3.80284416844719	0.207892820966401	0.586255226121228	X:78129747-78139706:-	TAF9B	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000124,cellular_component SAGA complex;GO:0001075,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly;GO:0003714,molecular_function transcription corepressor activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0016579,biological_process protein deubiquitination;GO:0030307,biological_process positive regulation of cell growth;GO:0033276,cellular_component transcription factor TFTC complex;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043966,biological_process histone H3 acetylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0050821,biological_process protein stabilization;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	TAF9B, TAF9; transcription initiation factor TFIID subunit 9B; K03133	TATA-box binding protein associated factor 9b [Source:HGNC Symbol%3BAcc:HGNC:17306]
ENSG00000187244	41.31	40.57	45.49	38.60	39.38	42.80	0.0895257229474245	6.30105637986428	0.207941364342906	0.586255226121228	19:44809058-44821420:+	BCAM	15;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005055,molecular_function laminin receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043236,molecular_function laminin binding;GO:0070062,cellular_component extracellular exosome	NA	basal cell adhesion molecule (Lutheran blood group) [Source:HGNC Symbol%3BAcc:HGNC:6722]
ENSG00000144589	5.52	7.01	6.42	6.97	7.31	6.53	-0.130295893616142	4.58227021101935	0.207976389850478	0.586255226121228	2:219597859-219616451:+	STK11IP	2;GO:0005765,cellular_component lysosomal membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	serine/threonine kinase 11 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:19184]
ENSG00000134996	34.65	32.30	30.04	30.79	28.00	31.22	0.119417364587639	4.33400476603529	0.208018312413418	0.586255226121228	9:75088542-75147265:+	OSTF1	11;GO:0001503,biological_process ossification;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	osteoclast stimulating factor 1 [Source:HGNC Symbol%3BAcc:HGNC:8510]
ENSG00000178996	2.45	1.92	2.83	2.21	1.95	2.07	0.234747340643756	2.31078203200303	0.20807334300393	0.586255226121228	5:54517758-54546585:+	SNX18	24;GO:0000278,biological_process mitotic cell cycle;GO:0000281,biological_process mitotic cytokinesis;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0007049,biological_process cell cycle;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036089,biological_process cleavage furrow formation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome	NA	sorting nexin 18 [Source:HGNC Symbol%3BAcc:HGNC:19245]
ENSG00000090447	10.38	9.76	10.39	11.22	10.06	13.08	-0.158099330055732	3.52773183080665	0.208113020224737	0.586255226121228	16:4257185-4273075:-	TFAP4	33;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0017053,cellular_component transcriptional repressor complex;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043392,biological_process negative regulation of DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0070888,molecular_function E-box binding;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:1901990,biological_process regulation of mitotic cell cycle phase transition;GO:2001269,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TFAP4; transcription factor AP-4; K09108	transcription factor AP-4 [Source:HGNC Symbol%3BAcc:HGNC:11745]
ENSG00000163516	44.20	39.18	46.13	40.56	39.11	42.84	0.0941466640170554	6.51994603500918	0.208138788489185	0.586255226121228	2:219229756-219236669:+	ANKZF1	9;GO:0003676,molecular_function nucleic acid binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0036266,cellular_component Cdc48p-Npl4p-Vms1p AAA ATPase complex;GO:0046872,molecular_function metal ion binding;GO:0071630,biological_process nucleus-associated proteasomal ubiquitin-dependent protein catabolic process;GO:0072671,biological_process mitochondria-associated ubiquitin-dependent protein catabolic process	NA	ankyrin repeat and zinc finger domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25527]
ENSG00000111276	72.74	76.04	72.90	69.57	65.72	74.72	0.0872080984358653	5.72698436606337	0.208365670014717	0.586610603351099	12:12715057-12722371:+	CDKN1B	68;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0001666,biological_process response to hypoxia;GO:0001890,biological_process placenta development;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005072,molecular_function transforming growth factor beta receptor, cytoplasmic mediator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006813,biological_process potassium ion transport;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007096,biological_process regulation of exit from mitosis;GO:0007219,biological_process Notch signaling pathway;GO:0007605,biological_process sensory perception of sound;GO:0008219,biological_process cell death;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009749,biological_process response to glucose;GO:0010942,biological_process positive regulation of cell death;GO:0014070,biological_process response to organic cyclic compound;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030308,biological_process negative regulation of cell growth;GO:0030332,molecular_function cyclin binding;GO:0030544,molecular_function Hsp70 protein binding;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0033673,biological_process negative regulation of kinase activity;GO:0042127,biological_process regulation of cell proliferation;GO:0042326,biological_process negative regulation of phosphorylation;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043200,biological_process response to amino acid;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045787,biological_process positive regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0046686,biological_process response to cadmium ion;GO:0048102,biological_process autophagic cell death;GO:0048839,biological_process inner ear development;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051087,molecular_function chaperone binding;GO:0051271,biological_process negative regulation of cellular component movement;GO:0060770,biological_process negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0071236,biological_process cellular response to antibiotic;GO:0071285,biological_process cellular response to lithium ion;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071850,biological_process mitotic cell cycle arrest;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:1902746,biological_process regulation of lens fiber cell differentiation;GO:1904030,biological_process negative regulation of cyclin-dependent protein kinase activity;GO:1904706,biological_process negative regulation of vascular smooth muscle cell proliferation	CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B; K06624	cyclin dependent kinase inhibitor 1B [Source:HGNC Symbol%3BAcc:HGNC:1785]
ENSG00000254206	0.94	0.41	1.13	0.68	0.60	0.67	0.382800729585996	1.5774157003204	0.2083930952112	0.586610603351099	16:29381353-29404029:-	NPIPB11	3;GO:0005654,cellular_component nucleoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear pore complex interacting protein family member B11 [Source:HGNC Symbol%3BAcc:HGNC:37453]
ENSG00000250565	1.46	3.52	2.17	2.76	3.13	3.32	-0.402535419129629	0.983834481651454	0.208421090720473	0.586610603351099	2:46490749-46542557:-	ATP6V1E2	15;GO:0001669,cellular_component acrosomal vesicle;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008553,molecular_function hydrogen-exporting ATPase activity, phosphorylative mechanism;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016241,biological_process regulation of macroautophagy;GO:0033178,cellular_component proton-transporting two-sector ATPase complex, catalytic domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0090383,biological_process phagosome acidification	ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E; K02150	ATPase H+ transporting V1 subunit E2 [Source:HGNC Symbol%3BAcc:HGNC:18125]
ENSG00000203872	1.22	0.77	1.49	0.76	0.38	1.35	0.499603087270609	0.204133712492411	0.208497340666804	0.586610603351099	6:87344848-87365463:+	C6orf163	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	chromosome 6 open reading frame 163 [Source:HGNC Symbol%3BAcc:HGNC:21403]
ENSG00000151470	14.76	15.66	16.62	17.53	18.26	16.93	-0.152686082972944	3.33728329484997	0.20853072183304	0.586610603351099	4:129093316-129116640:+	C4orf33	1;GO:0005515,molecular_function protein binding	NA	chromosome 4 open reading frame 33 [Source:HGNC Symbol%3BAcc:HGNC:27025]
ENSG00000137547	85.33	89.11	76.21	91.90	87.15	89.71	-0.0912787408268905	6.33713697258632	0.208585364888253	0.586610603351099	8:54135209-54147901:+	MRPL15	13;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015934,cellular_component large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination;GO:1990830,biological_process cellular response to leukemia inhibitory factor	RP-L15, MRPL15, rplO; large subunit ribosomal protein L15; K02876	mitochondrial ribosomal protein L15 [Source:HGNC Symbol%3BAcc:HGNC:14054]
ENSG00000161654	32.42	29.65	34.54	35.13	34.81	35.07	-0.102846100857193	4.72434022084525	0.20866493021174	0.586610603351099	17:44034634-44067619:-	LSM12	NA	NA	LSM12 homolog [Source:HGNC Symbol%3BAcc:HGNC:26407]
ENSG00000021645	2.69	4.13	3.14	2.63	3.55	2.51	0.201249933417626	4.10837706009199	0.208690187956439	0.586610603351099	14:78170372-79868290:+	NRXN3	27;GO:0001525,biological_process angiogenesis;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005246,molecular_function calcium channel regulator activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007158,biological_process neuron cell-cell adhesion;GO:0007165,biological_process signal transduction;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0007411,biological_process axon guidance;GO:0007416,biological_process synapse assembly;GO:0007612,biological_process learning;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030534,biological_process adult behavior;GO:0035176,biological_process social behavior;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051965,biological_process positive regulation of synapse assembly;GO:0065009,biological_process regulation of molecular function;GO:0071625,biological_process vocalization behavior;GO:0090129,biological_process positive regulation of synapse maturation;GO:0097109,molecular_function neuroligin family protein binding;GO:0098793,cellular_component presynapse	NRXN; neurexin; K07377	neurexin 3 [Source:HGNC Symbol%3BAcc:HGNC:8010]
ENSG00000103319	12.80	11.66	11.72	11.61	12.39	9.26	0.136844759749846	4.66532651062686	0.208690278288766	0.586610603351099	16:22206281-22288732:+	EEF2K	29;GO:0000166,molecular_function nucleotide binding;GO:0002931,biological_process response to ischemia;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004686,molecular_function elongation factor-2 kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006414,biological_process translational elongation;GO:0006468,biological_process protein phosphorylation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0014069,cellular_component postsynaptic density;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031952,biological_process regulation of protein autophosphorylation;GO:0032869,biological_process cellular response to insulin stimulus;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045807,biological_process positive regulation of endocytosis;GO:0046777,biological_process protein autophosphorylation;GO:0051965,biological_process positive regulation of synapse assembly;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0071277,biological_process cellular response to calcium ion;GO:0071320,biological_process cellular response to cAMP;GO:0071454,biological_process cellular response to anoxia;GO:1990416,biological_process cellular response to brain-derived neurotrophic factor stimulus;GO:1990637,biological_process response to prolactin	EEF2K; elongation factor 2 kinase [EC:2.7.11.20]; K08292	eukaryotic elongation factor 2 kinase [Source:HGNC Symbol%3BAcc:HGNC:24615]
ENSG00000183742	0.14	0.45	0.37	0.35	0.30	0.74	-0.56931694038931	0.204967239185905	0.208754066398397	0.586657058230316	7:20134654-20217404:-	MACC1	11;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008083,molecular_function growth factor activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051781,biological_process positive regulation of cell division	NA	MACC1%2C MET transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:30215]
ENSG00000073169	12.28	11.90	11.74	10.89	10.39	12.23	0.110590852227366	4.5479795152186	0.208930084900058	0.586842604526144	22:50200978-50217616:+	SELENOO	1;GO:0005739,cellular_component mitochondrion	NA	selenoprotein O [Source:HGNC Symbol%3BAcc:HGNC:30395]
ENSG00000173457	116.37	122.99	118.63	125.89	123.04	133.07	-0.0844319765601526	5.87389403413926	0.208969043390678	0.586842604526144	11:64244479-64246941:-	PPP1R14B	6;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005737,cellular_component cytoplasm;GO:0042325,biological_process regulation of phosphorylation;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045087,biological_process innate immune response;GO:0050790,biological_process regulation of catalytic activity	NA	protein phosphatase 1 regulatory inhibitor subunit 14B [Source:HGNC Symbol%3BAcc:HGNC:9057]
ENSG00000163596	1.85	1.57	2.37	2.51	2.14	2.45	-0.264625307532212	1.78850580622224	0.209112142075083	0.586842604526144	2:202773149-202871985:-	ICA1L	4;GO:0001669,cellular_component acrosomal vesicle;GO:0005515,molecular_function protein binding;GO:0007286,biological_process spermatid development;GO:0019904,molecular_function protein domain specific binding	NA	islet cell autoantigen 1 like [Source:HGNC Symbol%3BAcc:HGNC:14442]
ENSG00000142544	3.52	2.75	3.17	2.80	2.98	2.09	0.292552388361791	1.66301273296948	0.209155673016714	0.586842604526144	19:51097605-51108370:-	CTU1	11;GO:0000049,molecular_function tRNA binding;GO:0002098,biological_process tRNA wobble uridine modification;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0016740,molecular_function transferase activity;GO:0034227,biological_process tRNA thio-modification	CTU1, NCS6; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]; K14168	cytosolic thiouridylase subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:29590]
ENSG00000073792	42.53	38.17	41.83	45.93	40.87	44.72	-0.0880482333927829	6.30825154573467	0.209178073426079	0.586842604526144	3:185643738-185825056:-	IGF2BP2	18;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0009653,biological_process anatomical structure morphogenesis;GO:0017148,biological_process negative regulation of translation;GO:0042035,biological_process regulation of cytokine biosynthetic process;GO:0043488,biological_process regulation of mRNA stability;GO:0045182,molecular_function translation regulator activity;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0051028,biological_process mRNA transport	NA	insulin like growth factor 2 mRNA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:28867]
ENSG00000130590	4.20	3.97	5.09	5.49	5.04	5.45	-0.247828977843807	1.88602931484543	0.209186333921452	0.586842604526144	20:63974112-63980008:-	SAMD10	NA	NA	sterile alpha motif domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:16129]
ENSG00000119725	28.71	29.06	29.40	33.58	28.64	31.42	-0.0919856560504651	5.79455044007268	0.209188221813705	0.586842604526144	14:73886616-73932511:+	ZNF410	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 410 [Source:HGNC Symbol%3BAcc:HGNC:20144]
ENSG00000144747	16.50	16.73	16.88	15.39	16.24	16.11	0.0814265455463871	5.74518973539826	0.209213931579047	0.586842604526144	3:69019826-69052303:-	TMF1	27;GO:0000139,cellular_component Golgi membrane;GO:0001675,biological_process acrosome assembly;GO:0001819,biological_process positive regulation of cytokine production;GO:0003677,molecular_function DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007286,biological_process spermatid development;GO:0007289,biological_process spermatid nucleus differentiation;GO:0008584,biological_process male gonad development;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0030317,biological_process sperm motility;GO:0032275,biological_process luteinizing hormone secretion;GO:0033327,biological_process Leydig cell differentiation;GO:0042742,biological_process defense response to bacterium;GO:0043066,biological_process negative regulation of apoptotic process;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0071407,biological_process cellular response to organic cyclic compound;GO:2000845,biological_process positive regulation of testosterone secretion	NA	TATA element modulatory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11870]
ENSG00000135722	12.05	10.01	12.34	11.55	9.98	10.00	0.146596304046679	3.97522973569357	0.209245578637937	0.586842604526144	16:67159930-67164570:+	FBXL8	5;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 8 [Source:HGNC Symbol%3BAcc:HGNC:17875]
ENSG00000108828	183.59	193.01	175.71	168.69	184.17	172.94	0.0821043149612154	7.77899500535026	0.209445337669655	0.587270155069671	17:43014604-43025123:-	VAT1	13;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0008270,molecular_function zinc ion binding;GO:0010637,biological_process negative regulation of mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	vesicle amine transport 1 [Source:HGNC Symbol%3BAcc:HGNC:16919]
ENSG00000126070	4.85	5.64	6.26	6.28	5.67	6.74	-0.149891603191833	3.96208881130085	0.209554294946654	0.587318063883326	1:35930717-36072500:+	AGO3	34;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006402,biological_process mRNA catabolic process;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016442,cellular_component RISC complex;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035194,biological_process posttranscriptional gene silencing by RNA;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0035198,molecular_function miRNA binding;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0035280,biological_process miRNA loading onto RISC involved in gene silencing by miRNA;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0070578,cellular_component RISC-loading complex;GO:0072091,biological_process regulation of stem cell proliferation;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling	ELF2C, AGO; eukaryotic translation initiation factor 2C; K11593	argonaute 3%2C RISC catalytic component [Source:HGNC Symbol%3BAcc:HGNC:18421]
ENSG00000178921	12.22	13.21	12.26	13.74	14.39	12.43	-0.0958240885089462	5.75550247995834	0.209592261809339	0.587318063883326	17:8247617-8270491:+	PFAS	14;GO:0000166,molecular_function nucleotide binding;GO:0004642,molecular_function phosphoribosylformylglycinamidine synthase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006189,biological_process 'de novo' IMP biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0009156,biological_process ribonucleoside monophosphate biosynthetic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016874,molecular_function ligase activity;GO:0042493,biological_process response to drug;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	PFAS, purL; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]; K01952	phosphoribosylformylglycinamidine synthase [Source:HGNC Symbol%3BAcc:HGNC:8863]
ENSG00000006715	47.25	47.15	43.88	45.24	53.12	50.09	-0.0910757586069842	7.01616106736554	0.209604368243223	0.587318063883326	7:38722962-38932394:-	VPS41	37;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0006623,biological_process protein targeting to vacuole;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006914,biological_process autophagy;GO:0008017,molecular_function microtubule binding;GO:0008333,biological_process endosome to lysosome transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030897,cellular_component HOPS complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0033263,cellular_component CORVET complex;GO:0034058,biological_process endosomal vesicle fusion;GO:0035542,biological_process regulation of SNARE complex assembly;GO:0042144,biological_process vacuole fusion, non-autophagic;GO:0042802,molecular_function identical protein binding;GO:0043621,molecular_function protein self-association;GO:0045055,biological_process regulated exocytosis;GO:0046872,molecular_function metal ion binding;GO:0046907,biological_process intracellular transport;GO:0051020,molecular_function GTPase binding;GO:0071439,cellular_component clathrin complex;GO:1902774,biological_process late endosome to lysosome transport	NA	VPS41%2C HOPS complex subunit [Source:HGNC Symbol%3BAcc:HGNC:12713]
ENSG00000160256	27.08	26.13	26.65	23.39	23.52	27.38	0.11556715969641	4.45159516201465	0.209719724460268	0.587508675180615	21:44940009-44976989:+	FAM207A	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 207 member A [Source:HGNC Symbol%3BAcc:HGNC:15811]
ENSG00000198551	12.00	13.06	10.32	12.94	13.27	12.76	-0.135087700001581	4.11023043780594	0.209835861387714	0.587701387050022	19:11559373-11619135:+	ZNF627	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 627 [Source:HGNC Symbol%3BAcc:HGNC:30570]
ENSG00000277258	37.69	36.60	42.74	42.28	41.82	42.02	-0.0931467319983924	5.52188159600119	0.209929666965	0.587831481172241	17:38733896-38749817:-	PCGF2	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001701,biological_process in utero embryonic development;GO:0001739,cellular_component sex chromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016573,biological_process histone acetylation;GO:0016604,cellular_component nuclear body;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex;GO:0046872,molecular_function metal ion binding;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	PCGF2, RNF110; polycomb group RING finger protein 2; K11460	polycomb group ring finger 2 [Source:HGNC Symbol%3BAcc:HGNC:12929]
ENSG00000180071	2.48	2.07	2.39	2.48	2.37	3.16	-0.18864619067085	2.96343106139572	0.210111724118954	0.588208577241448	9:38571357-38620660:-	ANKRD18A	NA	NA	ankyrin repeat domain 18A [Source:HGNC Symbol%3BAcc:HGNC:23643]
ENSG00000089157	1755.73	1762.65	1791.68	1770.95	1633.13	1683.45	0.0735003493205156	10.7972854218095	0.210271174094354	0.588498146828823	12:120196685-120201235:-	RPLP0	24;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0042254,biological_process ribosome biogenesis;GO:0070062,cellular_component extracellular exosome	RP-LP0, RPLP0; large subunit ribosomal protein LP0; K02941	ribosomal protein lateral stalk subunit P0 [Source:HGNC Symbol%3BAcc:HGNC:10371]
ENSG00000138459	15.60	17.43	17.01	16.54	19.32	18.80	-0.119603195656754	4.48228840990811	0.210309979806063	0.588498146828823	3:112561708-112585577:+	SLC35A5	7;GO:0000139,cellular_component Golgi membrane;GO:0005351,molecular_function sugar:proton symporter activity;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member A5 [Source:HGNC Symbol%3BAcc:HGNC:20792]
ENSG00000104808	1.55	1.91	0.95	1.27	0.83	1.12	0.431137215371277	0.492681031717562	0.21036980382431	0.588532876914842	19:48933681-48944969:+	DHDH	8;GO:0005975,biological_process carbohydrate metabolic process;GO:0008746,molecular_function NAD(P)+ transhydrogenase activity;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0042843,biological_process D-xylose catabolic process;GO:0047115,molecular_function trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0047837,molecular_function D-xylose 1-dehydrogenase (NADP+) activity;GO:0055114,biological_process oxidation-reduction process	DHDH; dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179]; K00078	dihydrodiol dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:17887]
ENSG00000256087	7.89	7.80	7.43	6.49	7.70	7.06	0.132644065859717	3.87200340013307	0.210483152105611	0.588539106277762	19:52031378-52095738:-	ZNF432	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 432 [Source:HGNC Symbol%3BAcc:HGNC:20810]
ENSG00000164808	27.25	24.54	26.18	28.10	26.82	28.40	-0.0817672733662765	6.31121209195132	0.21049282685332	0.588539106277762	8:47260574-47736306:+	SPIDR	15;GO:0000228,cellular_component nuclear chromosome;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0070202,biological_process regulation of establishment of protein localization to chromosome;GO:0071479,biological_process cellular response to ionizing radiation;GO:0072711,biological_process cellular response to hydroxyurea;GO:0072757,biological_process cellular response to camptothecin;GO:2000781,biological_process positive regulation of double-strand break repair	NA	scaffolding protein involved in DNA repair [Source:HGNC Symbol%3BAcc:HGNC:28971]
ENSG00000100413	24.66	28.10	24.40	23.01	26.65	21.37	0.127033125419999	4.49231921366364	0.2105312064627	0.588539106277762	22:41525803-41544606:-	POLR3H	17;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0006384,biological_process transcription initiation from RNA polymerase III promoter;GO:0032481,biological_process positive regulation of type I interferon production;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045087,biological_process innate immune response;GO:0051607,biological_process defense response to virus	RPC8, POLR3H; DNA-directed RNA polymerase III subunit RPC8; K03022	RNA polymerase III subunit H [Source:HGNC Symbol%3BAcc:HGNC:30349]
ENSG00000186230	4.84	5.28	4.92	6.06	5.49	5.15	-0.143338372360753	3.64348836695592	0.210580670357136	0.588539106277762	19:57435328-57445485:+	ZNF749	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 749 [Source:HGNC Symbol%3BAcc:HGNC:32783]
ENSG00000173473	40.14	43.01	39.19	42.82	44.34	43.21	-0.0813462563421388	7.12743102423449	0.210626101387015	0.588539106277762	3:47585271-47782106:-	SMARCC1	32;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001741,cellular_component XY body;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009887,biological_process organ morphogenesis;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0030850,biological_process prostate gland development;GO:0031492,molecular_function nucleosomal DNA binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047485,molecular_function protein N-terminus binding;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:0090544,cellular_component BAF-type complex	SMARCC; SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C; K11649	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin subfamily c member 1 [Source:HGNC Symbol%3BAcc:HGNC:11104]
ENSG00000156509	2.50	3.03	2.91	3.59	2.79	3.34	-0.201582498835524	2.7336012523457	0.210658409993124	0.588539106277762	8:100133359-100145800:-	FBXO43	7;GO:0005634,cellular_component nucleus;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0016567,biological_process protein ubiquitination;GO:0045835,biological_process negative regulation of meiotic nuclear division;GO:0046872,molecular_function metal ion binding;GO:0051321,biological_process meiotic cell cycle;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	FBXO43, EMI2; F-box protein 43; K10318	F-box protein 43 [Source:HGNC Symbol%3BAcc:HGNC:28521]
ENSG00000135766	22.05	20.86	22.98	22.67	22.67	26.30	-0.107212235006154	4.88370655647074	0.210770398999199	0.588539106277762	1:231363750-231425044:-	EGLN1	31;GO:0001666,biological_process response to hypoxia;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006879,biological_process cellular iron ion homeostasis;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0018401,biological_process peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0019899,molecular_function enzyme binding;GO:0030821,biological_process negative regulation of cAMP catabolic process;GO:0031418,molecular_function L-ascorbic acid binding;GO:0031543,molecular_function peptidyl-proline dioxygenase activity;GO:0031545,molecular_function peptidyl-proline 4-dioxygenase activity;GO:0032364,biological_process oxygen homeostasis;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045765,biological_process regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051344,biological_process negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0055008,biological_process cardiac muscle tissue morphogenesis;GO:0055114,biological_process oxidation-reduction process;GO:0060347,biological_process heart trabecula formation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060711,biological_process labyrinthine layer development;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0071731,biological_process response to nitric oxide;GO:1901214,biological_process regulation of neuron death	EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]; K09592	egl-9 family hypoxia inducible factor 1 [Source:HGNC Symbol%3BAcc:HGNC:1232]
ENSG00000104231	86.47	71.37	94.87	97.46	78.56	103.89	-0.133488194474573	6.26965759572106	0.210778061251396	0.588539106277762	8:81701333-81732903:-	ZFAND1	2;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger AN1-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25858]
ENSG00000106803	184.66	232.28	175.82	176.00	195.66	177.02	0.118610913232193	5.77618678264866	0.210837113236714	0.588539106277762	9:99222063-99230615:+	SEC61B	22;GO:0000060,biological_process protein import into nucleus, translocation;GO:0003723,molecular_function RNA binding;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005784,cellular_component Sec61 translocon complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006616,biological_process SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0015450,molecular_function P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0031204,biological_process posttranslational protein targeting to membrane, translocation;GO:0031205,cellular_component endoplasmic reticulum Sec complex;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048408,molecular_function epidermal growth factor binding	SEC61B, SBH2; protein transport protein SEC61 subunit beta; K09481	Sec61 translocon beta subunit [Source:HGNC Symbol%3BAcc:HGNC:16993]
ENSG00000170293	1.09	1.66	1.42	2.02	2.19	1.63	-0.490526216948594	0.0193963565992098	0.210846161735053	0.588539106277762	3:32238678-32370325:+	CMTM8	13;GO:0001766,biological_process membrane raft polarization;GO:0005125,molecular_function cytokine activity;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006935,biological_process chemotaxis;GO:0008104,biological_process protein localization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019911,molecular_function structural constituent of myelin sheath;GO:0042552,biological_process myelination;GO:0045121,cellular_component membrane raft	NA	CKLF like MARVEL transmembrane domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:19179]
ENSG00000133872	88.49	92.27	93.51	79.97	89.92	90.46	0.0863958340662285	6.6577789541749	0.210947717208203	0.58859493281923	8:30063011-30083208:-	SARAF	10;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:2001256,biological_process regulation of store-operated calcium entry	NA	store-operated calcium entry associated regulatory factor [Source:HGNC Symbol%3BAcc:HGNC:28789]
ENSG00000247596	47.22	47.92	47.03	45.34	45.13	44.93	0.0813180959057756	5.60269284429558	0.210960997028338	0.58859493281923	3:52228609-52239260:-	TWF2	30;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0010976,biological_process positive regulation of neuron projection development;GO:0030016,cellular_component myofibril;GO:0030027,cellular_component lamellipodium;GO:0030030,biological_process cell projection organization;GO:0030175,cellular_component filopodium;GO:0030426,cellular_component growth cone;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0032420,cellular_component stereocilium;GO:0032532,biological_process regulation of microvillus length;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0042989,biological_process sequestering of actin monomers;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0045773,biological_process positive regulation of axon extension;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051016,biological_process barbed-end actin filament capping;GO:0070062,cellular_component extracellular exosome;GO:0071300,biological_process cellular response to retinoic acid;GO:0071363,biological_process cellular response to growth factor stimulus	NA	twinfilin actin binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9621]
ENSG00000146223	80.60	78.34	76.74	82.71	82.31	86.08	-0.0797174338886951	6.06228642161673	0.211110003705013	0.588597678785613	6:42879617-42889925:+	RPL7L1	9;GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001825,biological_process blastocyst formation;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005730,cellular_component nucleolus;GO:0005840,cellular_component ribosome;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	ribosomal protein L7 like 1 [Source:HGNC Symbol%3BAcc:HGNC:21370]
ENSG00000275700	61.38	57.53	58.15	62.45	59.87	66.97	-0.0840204947227678	6.68512995905092	0.211139997179476	0.588597678785613	17:36948874-37056871:+	AATF	21;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007155,biological_process cell adhesion;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0019904,molecular_function protein domain specific binding;GO:0032929,biological_process negative regulation of superoxide anion generation;GO:0040016,biological_process embryonic cleavage;GO:0042254,biological_process ribosome biogenesis;GO:0042985,biological_process negative regulation of amyloid precursor protein biosynthetic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043522,molecular_function leucine zipper domain binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048156,molecular_function tau protein binding;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	NA	apoptosis antagonizing transcription factor [Source:HGNC Symbol%3BAcc:HGNC:19235]
ENSG00000182208	17.22	17.65	15.95	16.60	13.64	16.11	0.140471154291893	3.73184903203063	0.211143504195807	0.588597678785613	11:1469456-1501247:-	MOB2	11;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010976,biological_process positive regulation of neuron projection development;GO:0030036,biological_process actin cytoskeleton organization;GO:0044306,cellular_component neuron projection terminus;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	MOB kinase activator 2 [Source:HGNC Symbol%3BAcc:HGNC:24904]
ENSG00000120685	8.40	7.19	7.67	6.69	7.44	7.50	0.12177549383081	4.41846077534087	0.211202323460474	0.588597678785613	13:39009865-39038076:-	PROSER1	NA	NA	proline and serine rich 1 [Source:HGNC Symbol%3BAcc:HGNC:20291]
ENSG00000118193	6.86	8.27	6.31	7.48	8.79	7.34	-0.132556154786634	5.21736741451801	0.211238617518955	0.588597678785613	1:200551496-200620734:-	KIF14	51;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0007018,biological_process microtubule-based movement;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008017,molecular_function microtubule binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0019901,molecular_function protein kinase binding;GO:0021685,biological_process cerebellar granular layer structural organization;GO:0021693,biological_process cerebellar Purkinje cell layer structural organization;GO:0021695,biological_process cerebellar cortex development;GO:0021766,biological_process hippocampus development;GO:0021772,biological_process olfactory bulb development;GO:0021846,biological_process cell proliferation in forebrain;GO:0021987,biological_process cerebral cortex development;GO:0030155,biological_process regulation of cell adhesion;GO:0030165,molecular_function PDZ domain binding;GO:0030334,biological_process regulation of cell migration;GO:0030496,cellular_component midbody;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031641,biological_process regulation of myelination;GO:0032147,biological_process activation of protein kinase activity;GO:0032467,biological_process positive regulation of cytokinesis;GO:0032487,biological_process regulation of Rap protein signal transduction;GO:0033624,biological_process negative regulation of integrin activation;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045184,biological_process establishment of protein localization;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:1903047,biological_process mitotic cell cycle process;GO:1903429,biological_process regulation of cell maturation;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	NA	kinesin family member 14 [Source:HGNC Symbol%3BAcc:HGNC:19181]
ENSG00000090013	122.22	113.63	125.60	108.59	114.27	120.75	0.0863626440870564	6.45799682276853	0.211246488277605	0.588597678785613	19:40447788-40465840:-	BLVRB	11;GO:0004074,molecular_function biliverdin reductase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0042167,biological_process heme catabolic process;GO:0042602,molecular_function riboflavin reductase (NADPH) activity;GO:0043195,cellular_component terminal bouton;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	BLVRB; biliverdin reductase / flavin reductase [EC:1.3.1.24 1.5.1.30]; K05901	biliverdin reductase B [Source:HGNC Symbol%3BAcc:HGNC:1063]
ENSG00000130766	31.09	30.06	30.21	30.94	33.34	33.55	-0.0861234945000202	5.51134987345889	0.21134320361036	0.58873500592805	1:28259526-28282491:+	SESN2	44;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006635,biological_process fatty acid beta-oxidation;GO:0007005,biological_process mitochondrion organization;GO:0009749,biological_process response to glucose;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016491,molecular_function oxidoreductase activity;GO:0016684,molecular_function oxidoreductase activity, acting on peroxide as acceptor;GO:0030308,biological_process negative regulation of cell growth;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0031932,cellular_component TORC2 complex;GO:0032042,biological_process mitochondrial DNA metabolic process;GO:0032542,molecular_function sulfiredoxin activity;GO:0032868,biological_process response to insulin;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034599,biological_process cellular response to oxidative stress;GO:0036091,biological_process positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0042149,biological_process cellular response to glucose starvation;GO:0042593,biological_process glucose homeostasis;GO:0043491,biological_process protein kinase B signaling;GO:0046323,biological_process glucose import;GO:0055114,biological_process oxidation-reduction process;GO:0061700,cellular_component GATOR2 complex;GO:0070328,biological_process triglyceride homeostasis;GO:0070728,molecular_function leucine binding;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071233,biological_process cellular response to leucine;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090526,biological_process regulation of gluconeogenesis involved in cellular glucose homeostasis;GO:0098869,biological_process cellular oxidant detoxification;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901031,biological_process regulation of response to reactive oxygen species;GO:1902010,biological_process negative regulation of translation in response to endoplasmic reticulum stress;GO:1904262,biological_process negative regulation of TORC1 signaling;GO:1904504,biological_process positive regulation of lipophagy;GO:1990253,biological_process cellular response to leucine starvation;GO:1990316,cellular_component ATG1/ULK1 kinase complex;GO:2000479,biological_process regulation of cAMP-dependent protein kinase activity	SESN1_3; sestrin 1/3; K10141	sestrin 2 [Source:HGNC Symbol%3BAcc:HGNC:20746]
ENSG00000099385	18.25	19.27	15.09	17.35	19.59	21.21	-0.138804880670275	4.47891666909972	0.21148103714115	0.588986787981398	16:30833625-30894960:-	BCL7C	1;GO:0006915,biological_process apoptotic process	NA	BCL tumor suppressor 7C [Source:HGNC Symbol%3BAcc:HGNC:1006]
ENSG00000119640	29.43	25.56	24.96	25.39	21.46	26.03	0.147562663527033	3.73527202508237	0.211742593606107	0.589525371276856	14:75053220-75069483:-	ACYP1	4;GO:0003998,molecular_function acylphosphatase activity;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	acyP; acylphosphatase [EC:3.6.1.7]; K01512	acylphosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:179]
ENSG00000276234	13.40	11.89	13.76	14.21	14.07	14.48	-0.112058662532646	4.29425839106325	0.211769405504189	0.589525371276856	17:37406873-37479730:+	TADA2A	15;GO:0000278,biological_process mitotic cell cycle;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0031063,biological_process regulation of histone deacetylation;GO:0031647,biological_process regulation of protein stability;GO:0035065,biological_process regulation of histone acetylation;GO:0072686,cellular_component mitotic spindle;GO:0090043,biological_process regulation of tubulin deacetylation	NA	transcriptional adaptor 2A [Source:HGNC Symbol%3BAcc:HGNC:11531]
ENSG00000049245	160.09	173.61	160.45	150.49	163.06	154.47	0.0870295867944733	5.59182064539792	0.212116143607076	0.590287729123436	1:7771268-7781432:+	VAMP3	44;GO:0000149,molecular_function SNARE binding;GO:0001921,biological_process positive regulation of receptor recycling;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006906,biological_process vesicle fusion;GO:0009986,cellular_component cell surface;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016324,cellular_component apical plasma membrane;GO:0017075,molecular_function syntaxin-1 binding;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0030054,cellular_component cell junction;GO:0030133,cellular_component transport vesicle;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030141,cellular_component secretory granule;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035493,biological_process SNARE complex assembly;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043005,cellular_component neuron projection;GO:0043229,cellular_component intracellular organelle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045202,cellular_component synapse;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0061025,biological_process membrane fusion;GO:1903531,biological_process negative regulation of secretion by cell	VAMP3; vesicle-associated membrane protein 3; K13505	vesicle associated membrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:12644]
ENSG00000134287	4.03	7.04	4.61	7.17	5.87	6.09	-0.306492501470385	1.71007852936648	0.212223547034574	0.590287729123436	12:48935722-48957551:-	ARF3	15;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	ARF3; ADP-ribosylation factor 3; K07938	ADP ribosylation factor 3 [Source:HGNC Symbol%3BAcc:HGNC:654]
ENSG00000130751	0.76	0.59	0.75	1.27	0.68	0.87	-0.398652991599219	0.696548581747599	0.212225798868936	0.590287729123436	19:47019819-47045775:+	NPAS1	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001964,biological_process startle response;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007417,biological_process central nervous system development;GO:0042711,biological_process maternal behavior;GO:0046983,molecular_function protein dimerization activity	NA	neuronal PAS domain protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7894]
ENSG00000160113	37.53	29.88	33.58	29.47	29.91	34.75	0.117393727049371	5.31013513434333	0.212233475797784	0.590287729123436	19:17231882-17245940:-	NR2F6	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004887,molecular_function thyroid hormone receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:0048666,biological_process neuron development;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain	NA	nuclear receptor subfamily 2 group F member 6 [Source:HGNC Symbol%3BAcc:HGNC:7977]
ENSG00000146063	32.23	29.59	30.61	32.45	32.18	34.07	-0.0810084196220447	5.99608425132196	0.212462264995601	0.590791688035482	5:181222498-181235809:+	TRIM41	11;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 41 [Source:HGNC Symbol%3BAcc:HGNC:19013]
ENSG00000100220	56.59	59.93	52.76	59.45	61.17	60.20	-0.0856129667322984	6.46875808188481	0.212624166330867	0.591109468458017	22:32387581-32412255:-	RTCB	20;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003972,molecular_function RNA ligase (ATP) activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006396,biological_process RNA processing;GO:0008033,biological_process tRNA processing;GO:0008452,molecular_function RNA ligase activity;GO:0016874,molecular_function ligase activity;GO:0017166,molecular_function vinculin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0072669,cellular_component tRNA-splicing ligase complex	NA	RNA 2'%2C3'-cyclic phosphate and 5'-OH ligase [Source:HGNC Symbol%3BAcc:HGNC:26935]
ENSG00000119048	66.24	65.57	71.11	75.43	69.71	73.09	-0.0916791594086829	5.23080673058556	0.212720767633342	0.591245608739963	5:134371178-134391992:+	UBE2B	49;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0001701,biological_process in utero embryonic development;GO:0001741,cellular_component XY body;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006301,biological_process postreplication repair;GO:0006344,biological_process maintenance of chromatin silencing;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0007288,biological_process sperm axoneme assembly;GO:0009411,biological_process response to UV;GO:0010845,biological_process positive regulation of reciprocal meiotic recombination;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031056,biological_process regulation of histone modification;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033128,biological_process negative regulation of histone phosphorylation;GO:0033503,cellular_component HULC complex;GO:0033522,biological_process histone H2A ubiquitination;GO:0042493,biological_process response to drug;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043951,biological_process negative regulation of cAMP-mediated signaling;GO:0045141,biological_process meiotic telomere clustering;GO:0050821,biological_process protein stabilization;GO:0051026,biological_process chiasma assembly;GO:0051865,biological_process protein autoubiquitination;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070076,biological_process histone lysine demethylation;GO:0070193,biological_process synaptonemal complex organization;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination	NA	ubiquitin conjugating enzyme E2 B [Source:HGNC Symbol%3BAcc:HGNC:12473]
ENSG00000114023	50.27	57.12	48.69	46.92	53.25	44.20	0.119628727365675	4.69869153753469	0.212836722170461	0.591435467271531	3:122384175-122412334:+	FAM162A	12;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043065,biological_process positive regulation of apoptotic process;GO:0051402,biological_process neuron apoptotic process;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria	NA	family with sequence similarity 162 member A [Source:HGNC Symbol%3BAcc:HGNC:17865]
ENSG00000198131	8.35	7.52	8.55	8.89	8.54	9.26	-0.110153012332215	4.39986154827121	0.212970020069134	0.591582765417477	19:58228593-58277495:+	ZNF544	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 544 [Source:HGNC Symbol%3BAcc:HGNC:16759]
ENSG00000124356	36.09	35.84	33.68	36.32	38.22	38.42	-0.0865622178909007	5.53980564224308	0.213041398324193	0.591582765417477	2:73828915-73873659:+	STAMBP	25;GO:0000281,biological_process mitotic cytokinesis;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007259,biological_process JAK-STAT cascade;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019904,molecular_function protein domain specific binding;GO:0032154,cellular_component cleavage furrow;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	STAMBP, AMSH; STAM-binding protein [EC:3.4.19.12]; K11866	STAM binding protein [Source:HGNC Symbol%3BAcc:HGNC:16950]
ENSG00000107263	8.93	10.63	9.99	11.10	10.22	10.59	-0.103590548791625	5.31236366925035	0.213065109181991	0.591582765417477	9:131576769-131740074:-	RAPGEF1	37;GO:0000186,biological_process activation of MAPKK activity;GO:0001568,biological_process blood vessel development;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007399,biological_process nervous system development;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0017034,molecular_function Rap guanyl-nucleotide exchange factor activity;GO:0017124,molecular_function SH3 domain binding;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0032486,biological_process Rap protein signal transduction;GO:0038180,biological_process nerve growth factor signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046328,biological_process regulation of JNK cascade;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0061028,biological_process establishment of endothelial barrier;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071320,biological_process cellular response to cAMP;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1901888,biological_process regulation of cell junction assembly;GO:1905451,biological_process positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000178,biological_process negative regulation of neural precursor cell proliferation	RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1; K06277	Rap guanine nucleotide exchange factor 1 [Source:HGNC Symbol%3BAcc:HGNC:4568]
ENSG00000221978	113.66	107.64	125.81	108.73	106.47	114.32	0.087632200870278	7.68368220798471	0.213103599657717	0.591582765417477	1:1385710-1399328:-	CCNL2	14;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0016607,cellular_component nuclear speck;GO:0019901,molecular_function protein kinase binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1901409,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain	NA	cyclin L2 [Source:HGNC Symbol%3BAcc:HGNC:20570]
ENSG00000086666	69.83	72.64	75.09	65.05	74.48	66.61	0.0895896342855237	5.98080377705138	0.21327519148031	0.591582765417477	15:80059567-80138393:+	ZFAND6	15;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0006625,biological_process protein targeting to peroxisome;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0031593,molecular_function polyubiquitin binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding;GO:0071356,biological_process cellular response to tumor necrosis factor	NA	zinc finger AN1-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:30164]
ENSG00000119729	51.00	50.13	55.62	47.70	49.87	50.95	0.0913826571176962	5.41533477949902	0.213281484108882	0.591582765417477	2:46541805-46583121:+	RHOQ	27;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0032427,molecular_function GBD domain binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0045121,cellular_component membrane raft;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046039,biological_process GTP metabolic process;GO:0046326,biological_process positive regulation of glucose import;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0070062,cellular_component extracellular exosome;GO:0090005,biological_process negative regulation of establishment of protein localization to plasma membrane	RHOQ, TC10; Ras homolog gene family, member Q; K07194	ras homolog family member Q [Source:HGNC Symbol%3BAcc:HGNC:17736]
ENSG00000187531	24.12	22.08	21.86	20.39	22.40	21.12	0.105501315215061	4.74572499191776	0.213311547348535	0.591582765417477	17:81911938-81921323:-	SIRT7	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005731,cellular_component nucleolus organizer region;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007072,biological_process positive regulation of transcription involved in exit from mitosis;GO:0009303,biological_process rRNA transcription;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070403,molecular_function NAD+ binding;GO:0070932,biological_process histone H3 deacetylation;GO:0070933,biological_process histone H4 deacetylation;GO:0097372,molecular_function NAD-dependent histone deacetylase activity (H3-K18 specific)	SIRT7, SIR2L7; NAD+-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]; K11417	sirtuin 7 [Source:HGNC Symbol%3BAcc:HGNC:14935]
ENSG00000153094	12.57	11.33	11.06	10.87	10.31	10.78	0.143844331761306	3.46863478724568	0.21335293321778	0.591582765417477	2:111119377-111168447:+	BCL2L11	60;GO:0001701,biological_process in utero embryonic development;GO:0001776,biological_process leukocyte homeostasis;GO:0001782,biological_process B cell homeostasis;GO:0001783,biological_process B cell apoptotic process;GO:0001822,biological_process kidney development;GO:0001844,biological_process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0002260,biological_process lymphocyte homeostasis;GO:0002262,biological_process myeloid cell homeostasis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0006915,biological_process apoptotic process;GO:0007160,biological_process cell-matrix adhesion;GO:0007283,biological_process spermatogenesis;GO:0007420,biological_process brain development;GO:0008017,molecular_function microtubule binding;GO:0008584,biological_process male gonad development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009791,biological_process post-embryonic development;GO:0010942,biological_process positive regulation of cell death;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0019898,cellular_component extrinsic component of membrane;GO:0030879,biological_process mammary gland development;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035148,biological_process tube formation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042981,biological_process regulation of apoptotic process;GO:0043029,biological_process T cell homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043583,biological_process ear development;GO:0045787,biological_process positive regulation of cell cycle;GO:0046620,biological_process regulation of organ growth;GO:0046982,molecular_function protein heterodimerization activity;GO:0048066,biological_process developmental pigmentation;GO:0048070,biological_process regulation of developmental pigmentation;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0048563,biological_process post-embryonic organ morphogenesis;GO:0060139,biological_process positive regulation of apoptotic process by virus;GO:0060154,biological_process cellular process regulating host cell cycle in response to virus;GO:0070242,biological_process thymocyte apoptotic process;GO:0070840,molecular_function dynein complex binding;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097136,cellular_component Bcl-2 family protein complex;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1902110,biological_process positive regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902263,biological_process apoptotic process involved in embryonic digit morphogenesis;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response;GO:2000271,biological_process positive regulation of fibroblast apoptotic process;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BCL2L11, BIM; Bcl-2-like protein 11; K16341	BCL2 like 11 [Source:HGNC Symbol%3BAcc:HGNC:994]
ENSG00000100567	168.39	157.40	165.77	175.68	167.45	180.71	-0.0790430986585915	7.01961389964611	0.21335819038716	0.591582765417477	14:58244830-58272012:+	PSMA3	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019773,cellular_component proteasome core complex, alpha-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045202,cellular_component synapse;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0052548,biological_process regulation of endopeptidase activity;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMA3; 20S proteasome subunit alpha 7 [EC:3.4.25.1]; K02727	proteasome subunit alpha 3 [Source:HGNC Symbol%3BAcc:HGNC:9532]
ENSG00000102606	7.97	8.98	9.37	8.43	8.15	7.98	0.109672751178168	4.661153683695	0.213366312799005	0.591582765417477	13:111114558-111305737:+	ARHGEF7	37;GO:0000322,cellular_component storage vacuole;GO:0001726,cellular_component ruffle;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007030,biological_process Golgi organization;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030054,cellular_component cell junction;GO:0032092,biological_process positive regulation of protein binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048041,biological_process focal adhesion assembly;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0060124,biological_process positive regulation of growth hormone secretion;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1904424,biological_process regulation of GTP binding;GO:2000394,biological_process positive regulation of lamellipodium morphogenesis	ARHGEF7, PIXB; Rho guanine nucleotide exchange factor 7; K13710	Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol%3BAcc:HGNC:15607]
ENSG00000104626	9.21	7.60	8.78	9.77	8.28	11.12	-0.170398765289814	3.33411591591436	0.21347746306336	0.591758764851606	8:9002146-9116746:+	ERI1	22;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006259,biological_process DNA metabolic process;GO:0006364,biological_process rRNA processing;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0019843,molecular_function rRNA binding;GO:0031047,biological_process gene silencing by RNA;GO:0031125,biological_process rRNA 3'-end processing;GO:0043022,molecular_function ribosome binding;GO:0046872,molecular_function metal ion binding;GO:0071204,cellular_component histone pre-mRNA 3'end processing complex;GO:0071207,molecular_function histone pre-mRNA stem-loop binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	exoribonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:23994]
ENSG00000157216	22.28	23.74	25.67	23.02	23.26	20.77	0.10916404465626	4.84396738703309	0.213598169945148	0.591961170691923	1:54225431-54413479:-	SSBP3	20;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0008284,biological_process positive regulation of cell proliferation;GO:0021501,biological_process prechordal plate formation;GO:0021547,biological_process midbrain-hindbrain boundary initiation;GO:0043234,cellular_component protein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060322,biological_process head development;GO:0060323,biological_process head morphogenesis;GO:2000744,biological_process positive regulation of anterior head development	NA	single stranded DNA binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:15674]
ENSG00000187726	1.53	0.90	1.73	1.13	0.86	1.19	0.428983706603434	0.554365885789941	0.213885901700626	0.592593889296022	11:73950318-73970366:+	DNAJB13	13;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006457,biological_process protein folding;GO:0030030,biological_process cell projection organization;GO:0031514,cellular_component motile cilium;GO:0036126,cellular_component sperm flagellum;GO:0042995,cellular_component cell projection;GO:0051082,molecular_function unfolded protein binding;GO:1904158,biological_process axonemal central apparatus assembly	NA	DnaJ heat shock protein family (Hsp40) member B13 [Source:HGNC Symbol%3BAcc:HGNC:30718]
ENSG00000103550	29.45	27.68	28.02	29.37	29.70	32.34	-0.0895916329954628	5.34524203428763	0.213921954236323	0.592593889296022	16:19701933-19718235:-	KNOP1	3;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus	NA	lysine rich nucleolar protein 1 [Source:HGNC Symbol%3BAcc:HGNC:34404]
ENSG00000198948	1.14	1.24	0.95	0.67	1.04	0.80	0.411100098264571	0.4257708114802	0.214123044095161	0.59301859579501	4:169986596-170033031:-	MFAP3L	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	microfibril associated protein 3 like [Source:HGNC Symbol%3BAcc:HGNC:29083]
ENSG00000170099	5.95	5.96	4.96	4.01	5.89	4.85	0.203290040607526	2.87111690815973	0.214292042047112	0.593269689194757	14:94304247-94323394:-	SERPINA6	9;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005496,molecular_function steroid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006810,biological_process transport;GO:0008211,biological_process glucocorticoid metabolic process;GO:0008289,molecular_function lipid binding;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0070062,cellular_component extracellular exosome	NA	serpin family A member 6 [Source:HGNC Symbol%3BAcc:HGNC:1540]
ENSG00000129158	12.12	10.23	9.37	9.81	10.14	9.18	0.138419003612549	4.26328183071731	0.21432775376693	0.593269689194757	11:17788047-18013162:-	SERGEF	12;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005087,molecular_function Ran guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0016235,cellular_component aggresome;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050709,biological_process negative regulation of protein secretion	NA	secretion regulating guanine nucleotide exchange factor [Source:HGNC Symbol%3BAcc:HGNC:17499]
ENSG00000149634	2.18	3.79	1.51	1.98	1.78	1.76	0.403978115511692	0.665133525404954	0.214357089828283	0.593269689194757	20:45886488-45887635:-	SPATA25	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation	NA	spermatogenesis associated 25 [Source:HGNC Symbol%3BAcc:HGNC:16158]
ENSG00000213066	29.73	32.76	30.00	32.11	36.30	31.44	-0.101618920188143	5.34779171052723	0.214469297277328	0.593318635232986	6:166999181-167052713:+	FGFR1OP	22;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030292,molecular_function protein tyrosine kinase inhibitor activity;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0034453,biological_process microtubule anchoring;GO:0042803,molecular_function protein homodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	FGFR1 oncogene partner [Source:HGNC Symbol%3BAcc:HGNC:17012]
ENSG00000167874	1.09	1.04	1.26	1.63	1.53	1.74	-0.508860940685442	0.0718447288426486	0.214470371085991	0.593318635232986	17:7855064-7856099:+	TMEM88	11;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030165,molecular_function PDZ domain binding;GO:0050821,biological_process protein stabilization;GO:0072659,biological_process protein localization to plasma membrane;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	transmembrane protein 88 [Source:HGNC Symbol%3BAcc:HGNC:32371]
ENSG00000126214	8.65	9.44	9.08	9.07	7.04	8.80	0.132339866758652	4.26302755823034	0.214578231006044	0.593463209420949	14:103561895-103714249:+	KLC1	17;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030426,cellular_component growth cone;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035617,biological_process stress granule disassembly;GO:0042995,cellular_component cell projection	KLC; kinesin light chain; K10407	kinesin light chain 1 [Source:HGNC Symbol%3BAcc:HGNC:6387]
ENSG00000135926	85.61	85.63	96.79	83.62	87.47	83.43	0.0877685306134952	6.34827895028512	0.214618250792769	0.593463209420949	2:218274191-218292586:-	TMBIM1	18;GO:0005123,molecular_function death receptor binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0090005,biological_process negative regulation of establishment of protein localization to plasma membrane;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902045,biological_process negative regulation of Fas signaling pathway;GO:2000504,biological_process positive regulation of blood vessel remodeling	NA	transmembrane BAX inhibitor motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23410]
ENSG00000170745	39.46	36.20	37.87	32.73	37.74	37.04	0.092353301252321	5.7676129102211	0.214938691918515	0.594097772276083	2:17877846-18361616:+	KCNS3	21;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005251,molecular_function delayed rectifier potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0050796,biological_process regulation of insulin secretion;GO:0051260,biological_process protein homooligomerization;GO:0055085,biological_process transmembrane transport;GO:0065009,biological_process regulation of molecular function;GO:0071805,biological_process potassium ion transmembrane transport	NA	potassium voltage-gated channel modifier subfamily S member 3 [Source:HGNC Symbol%3BAcc:HGNC:6302]
ENSG00000198089	11.09	10.33	9.54	11.34	11.15	10.84	-0.0937564496792939	5.35532709612709	0.214943454063634	0.594097772276083	22:31488687-31618586:+	SFI1	11;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019902,molecular_function phosphatase binding;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	SFI1 centrin binding protein [Source:HGNC Symbol%3BAcc:HGNC:29064]
ENSG00000075539	10.33	10.28	9.50	9.94	11.73	10.69	-0.0927035392498305	6.61372836421152	0.215006237118117	0.594139007423683	4:48497360-48780322:-	FRYL	7;GO:0000902,biological_process cell morphogenesis;GO:0005938,cellular_component cell cortex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030427,cellular_component site of polarized growth;GO:0031175,biological_process neuron projection development;GO:0090527,biological_process actin filament reorganization	NA	FRY like transcription coactivator [Source:HGNC Symbol%3BAcc:HGNC:29127]
ENSG00000130939	18.01	20.99	17.58	16.75	19.00	17.43	0.0982534281764255	6.20014079461259	0.215122581275069	0.594275060969963	1:10032831-10181239:+	UBE4B	25;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0008626,biological_process granzyme-mediated apoptotic signaling pathway;GO:0009411,biological_process response to UV;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031175,biological_process neuron projection development;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044257,biological_process cellular protein catabolic process;GO:0051117,molecular_function ATPase binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity	UBE4B, UFD2; ubiquitin conjugation factor E4 B [EC:2.3.2.27]; K10597	ubiquitination factor E4B [Source:HGNC Symbol%3BAcc:HGNC:12500]
ENSG00000142188	33.02	37.78	30.69	28.38	31.08	33.64	0.127041749568471	4.17508333038348	0.215263956553015	0.594275060969963	21:33432484-33480011:-	TMEM50B	6;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 50B [Source:HGNC Symbol%3BAcc:HGNC:1280]
ENSG00000110218	24.65	25.05	24.19	23.14	23.20	23.49	0.0913322587358872	4.9429932810441	0.215290018732655	0.594275060969963	11:94128927-94181972:+	PANX1	34;GO:0002020,molecular_function protease binding;GO:0002931,biological_process response to ischemia;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005243,molecular_function gap junction channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005921,cellular_component gap junction;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0007267,biological_process cell-cell signaling;GO:0015267,molecular_function channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022840,molecular_function leak channel activity;GO:0030054,cellular_component cell junction;GO:0032059,cellular_component bleb;GO:0033198,biological_process response to ATP;GO:0034214,biological_process protein hexamerization;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050717,biological_process positive regulation of interleukin-1 alpha secretion;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0051015,molecular_function actin filament binding;GO:0055077,molecular_function gap junction hemi-channel activity;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0097110,molecular_function scaffold protein binding	PANX1; pannexin 1; K03443	pannexin 1 [Source:HGNC Symbol%3BAcc:HGNC:8599]
ENSG00000173744	34.91	33.05	36.50	37.78	38.15	35.79	-0.0825346067588127	6.05062211811645	0.21532230689603	0.594275060969963	2:227472151-227561214:+	AGFG1	23;GO:0001675,biological_process acrosome assembly;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005829,cellular_component cytosol;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007289,biological_process spermatid nucleus differentiation;GO:0030154,biological_process cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045109,biological_process intermediate filament organization;GO:0046872,molecular_function metal ion binding;GO:0051028,biological_process mRNA transport;GO:0061024,biological_process membrane organization	NA	ArfGAP with FG repeats 1 [Source:HGNC Symbol%3BAcc:HGNC:5175]
ENSG00000085662	1783.32	1860.12	1716.99	1699.05	1769.27	1661.27	0.0751818789162725	10.8447748614298	0.215365604051424	0.594275060969963	7:134442349-134459284:-	AKR1B1	43;GO:0001894,biological_process tissue homeostasis;GO:0003091,biological_process renal water homeostasis;GO:0004032,molecular_function alditol:NADP+ 1-oxidoreductase activity;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005996,biological_process monosaccharide metabolic process;GO:0006061,biological_process sorbitol biosynthetic process;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0006950,biological_process response to stress;GO:0009055,molecular_function electron carrier activity;GO:0009414,biological_process response to water deprivation;GO:0010033,biological_process response to organic substance;GO:0016491,molecular_function oxidoreductase activity;GO:0018931,biological_process naphthalene metabolic process;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032838,cellular_component cell projection cytoplasm;GO:0033010,cellular_component paranodal junction;GO:0035809,biological_process regulation of urine volume;GO:0042415,biological_process norepinephrine metabolic process;GO:0042629,cellular_component mast cell granule;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043220,cellular_component Schmidt-Lanterman incisure;GO:0043795,molecular_function glyceraldehyde oxidoreductase activity;GO:0044597,biological_process daunorubicin metabolic process;GO:0044598,biological_process doxorubicin metabolic process;GO:0046370,biological_process fructose biosynthetic process;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0055114,biological_process oxidation-reduction process;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0072001,biological_process renal system development;GO:0072061,biological_process inner medullary collecting duct development;GO:0097066,biological_process response to thyroid hormone;GO:0097238,biological_process cellular response to methylglyoxal;GO:0097454,cellular_component Schwann cell microvillus;GO:1901653,biological_process cellular response to peptide	AKR1B; aldehyde reductase [EC:1.1.1.21]; K00011	aldo-keto reductase family 1 member B [Source:HGNC Symbol%3BAcc:HGNC:381]
ENSG00000111962	12.23	9.73	11.96	13.09	10.27	15.36	-0.173629349743887	3.90736649744245	0.215417660780132	0.594275060969963	6:148747327-149076990:+	UST	10;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006477,biological_process protein sulfation;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030010,biological_process establishment of cell polarity;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0050770,biological_process regulation of axonogenesis	UST; dermatan/chondrotin sulfate uronyl 2-O-sulfotransferase UST [EC:2.8.2.-]; K03193	uronyl 2-sulfotransferase [Source:HGNC Symbol%3BAcc:HGNC:17223]
ENSG00000125743	437.88	424.26	403.45	453.17	445.28	447.08	-0.0766731296952673	7.37185923674761	0.215434905138643	0.594275060969963	19:45687453-45692569:-	SNRPD2	27;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0034709,cellular_component methylosome;GO:0034715,cellular_component pICln-Sm protein complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0051170,biological_process nuclear import;GO:0070062,cellular_component extracellular exosome;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	SNRPD2, SMD2; small nuclear ribonucleoprotein D2; K11096	small nuclear ribonucleoprotein D2 polypeptide [Source:HGNC Symbol%3BAcc:HGNC:11159]
ENSG00000163611	5.92	6.89	7.09	6.68	5.91	5.62	0.136252503871178	4.03657866620385	0.215442290407544	0.594275060969963	3:113442717-113515187:-	SPICE1	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0046599,biological_process regulation of centriole replication;GO:0051301,biological_process cell division;GO:0051310,biological_process metaphase plate congression;GO:0090307,biological_process mitotic spindle assembly	NA	spindle and centriole associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:25083]
ENSG00000160932	275.31	304.66	293.44	274.95	286.04	271.91	0.0795880531649157	7.76873308113744	0.21550448782939	0.594275060969963	8:143017981-143023832:+	LY6E	7;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0031225,cellular_component anchored component of membrane	NA	lymphocyte antigen 6 family member E [Source:HGNC Symbol%3BAcc:HGNC:6727]
ENSG00000101126	35.46	34.57	36.20	36.71	37.83	38.43	-0.0763690844927054	6.91941569775431	0.215580374414132	0.594275060969963	20:50888918-50931240:-	ADNP	33;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007614,biological_process short-term memory;GO:0009743,biological_process response to carbohydrate;GO:0010035,biological_process response to inorganic substance;GO:0010629,biological_process negative regulation of gene expression;GO:0010835,biological_process regulation of protein ADP-ribosylation;GO:0010976,biological_process positive regulation of neuron projection development;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030828,biological_process positive regulation of cGMP biosynthetic process;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032091,biological_process negative regulation of protein binding;GO:0032147,biological_process activation of protein kinase activity;GO:0033484,biological_process nitric oxide homeostasis;GO:0042277,molecular_function peptide binding;GO:0043025,cellular_component neuronal cell body;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044849,biological_process estrous cycle;GO:0045773,biological_process positive regulation of axon extension;GO:0046872,molecular_function metal ion binding;GO:0048487,molecular_function beta-tubulin binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050805,biological_process negative regulation of synaptic transmission;GO:0051965,biological_process positive regulation of synapse assembly	NA	activity dependent neuroprotector homeobox [Source:HGNC Symbol%3BAcc:HGNC:15766]
ENSG00000104907	22.02	19.76	23.58	22.85	22.64	25.13	-0.0961312351777411	5.58356000401651	0.215601023734069	0.594275060969963	19:13104901-13117567:-	TRMT1	15;GO:0000049,molecular_function tRNA binding;GO:0002940,biological_process tRNA N2-guanine methylation;GO:0003723,molecular_function RNA binding;GO:0004809,molecular_function tRNA (guanine-N2-)-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	tRNA methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:25980]
ENSG00000135643	14.59	11.61	10.56	12.40	14.83	15.08	-0.185921385773463	3.09595859535935	0.215642625623014	0.594275060969963	12:70366275-70434292:+	KCNMB4	19;GO:0001508,biological_process action potential;GO:0005513,biological_process detection of calcium ion;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015269,molecular_function calcium-activated potassium channel activity;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019228,biological_process neuronal action potential;GO:0019229,biological_process regulation of vasoconstriction;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0065009,biological_process regulation of molecular function;GO:0071805,biological_process potassium ion transmembrane transport	KCNMB4; potassium large conductance calcium-activated channel subfamily M beta member 4; K04941	potassium calcium-activated channel subfamily M regulatory beta subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:6289]
ENSG00000102781	7.30	5.66	6.26	6.57	5.73	4.74	0.196801050761809	3.17854823190333	0.21567784980824	0.594275060969963	13:30202629-30307484:-	KATNAL1	20;GO:0000166,molecular_function nucleotide binding;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0008568,molecular_function microtubule-severing ATPase activity;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030496,cellular_component midbody;GO:0042802,molecular_function identical protein binding;GO:0051013,biological_process microtubule severing;GO:0051301,biological_process cell division	NA	katanin catalytic subunit A1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:28361]
ENSG00000197343	29.21	28.66	31.20	29.05	25.69	29.60	0.0910911254849115	5.8803925326086	0.215816251944571	0.594524441941402	7:99558405-99576453:+	ZNF655	13;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	zinc finger protein 655 [Source:HGNC Symbol%3BAcc:HGNC:30899]
ENSG00000022976	9.94	9.32	10.15	10.62	10.56	10.55	-0.0940084026515228	4.84487563545555	0.215930393960379	0.594706895990721	14:102317376-102342702:+	ZNF839	2;GO:0003676,molecular_function nucleic acid binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 839 [Source:HGNC Symbol%3BAcc:HGNC:20345]
ENSG00000121690	4.43	3.75	4.10	4.55	5.28	4.28	-0.177248497228418	2.83309607965011	0.216201912126218	0.59527927016463	11:33015863-33033582:+	DEPDC7	9;GO:0003674,molecular_function molecular_function;GO:0005096,molecular_function GTPase activator activity;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0008150,biological_process biological_process;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	DEP domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:29899]
ENSG00000132603	31.08	26.44	25.39	28.95	31.85	30.71	-0.126029990547187	4.14107924108678	0.216246200308913	0.59527927016463	16:69339429-69343111:+	NIP7	9;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042254,biological_process ribosome biogenesis;GO:0042255,biological_process ribosome assembly;GO:0042273,biological_process ribosomal large subunit biogenesis	NA	NIP7%2C nucleolar pre-rRNA processing protein [Source:HGNC Symbol%3BAcc:HGNC:24328]
ENSG00000134419	245.36	239.74	230.61	262.83	238.16	262.54	-0.0817703140808662	7.15741076953333	0.216282083979898	0.59527927016463	16:18781294-18790383:-	RPS15A	22;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0045787,biological_process positive regulation of cell cycle;GO:0070062,cellular_component extracellular exosome	RP-S15Ae, RPS15A; small subunit ribosomal protein S15Ae; K02957	ribosomal protein S15a [Source:HGNC Symbol%3BAcc:HGNC:10389]
ENSG00000108100	47.98	47.36	51.14	48.46	41.79	48.11	0.0946529207005499	5.61605635341587	0.216440809476785	0.595584076265867	10:35247024-35572669:+	CCNY	15;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000308,cellular_component cytoplasmic cyclin-dependent protein kinase holoenzyme complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0051301,biological_process cell division;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0070062,cellular_component extracellular exosome	NA	cyclin Y [Source:HGNC Symbol%3BAcc:HGNC:23354]
ENSG00000068796	14.50	14.23	13.30	14.06	14.62	16.92	-0.107972505958675	5.03794850788888	0.216592432510912	0.595629129725615	5:62306161-62537249:+	KIF2A	33;GO:0000166,molecular_function nucleotide binding;GO:0000922,cellular_component spindle pole;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0016887,molecular_function ATPase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030154,biological_process cell differentiation;GO:0051301,biological_process cell division;GO:0090307,biological_process mitotic spindle assembly;GO:0097228,cellular_component sperm principal piece	KIF2_24, MCAK; kinesin family member 2/24; K10393	kinesin family member 2A [Source:HGNC Symbol%3BAcc:HGNC:6318]
ENSG00000182742	11.35	9.77	11.05	13.52	13.50	9.99	-0.18045713794331	3.14759609889289	0.216663839436466	0.595629129725615	17:48575512-48580111:-	HOXB4	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0030097,biological_process hemopoiesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048103,biological_process somatic stem cell division;GO:0048536,biological_process spleen development;GO:0048539,biological_process bone marrow development;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0060216,biological_process definitive hemopoiesis;GO:0060218,biological_process hematopoietic stem cell differentiation;GO:2000738,biological_process positive regulation of stem cell differentiation	NA	homeobox B4 [Source:HGNC Symbol%3BAcc:HGNC:5115]
ENSG00000162825	0.32	0.28	0.28	0.31	0.38	0.32	-0.20381352449342	2.46782064838371	0.216831791398997	0.595629129725615	1:145289899-145405778:-	NBPF20	NA	NA	NBPF member 20 [Source:HGNC Symbol%3BAcc:HGNC:32000]
ENSG00000241322	0.51	0.30	0.55	0.44	0.24	0.35	0.434048279895673	0.529379936262235	0.216856333198967	0.595629129725615	17:15565482-15619512:-	CDRT1	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	CMT1A duplicated region transcript 1 [Source:HGNC Symbol%3BAcc:HGNC:14379]
ENSG00000138134	10.27	9.91	9.17	9.90	7.23	9.40	0.155638487051747	3.75833725826052	0.216859621223858	0.595629129725615	10:88879733-88975153:+	STAMBPL1	11;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070536,biological_process protein K63-linked deubiquitination	NA	STAM binding protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:24105]
ENSG00000166348	11.92	9.57	10.85	12.11	11.17	11.71	-0.0963976380546539	5.83269869535752	0.216859907909767	0.595629129725615	10:73497537-73625953:-	USP54	3;GO:0005515,molecular_function protein binding;GO:0016579,biological_process protein deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 54 [Source:HGNC Symbol%3BAcc:HGNC:23513]
ENSG00000197077	13.33	12.66	13.84	13.30	11.44	12.99	0.0909241018839223	6.22124460711724	0.216873943735259	0.595629129725615	22:24952729-25197448:+	KIAA1671	NA	NA	KIAA1671 [Source:HGNC Symbol%3BAcc:HGNC:29345]
ENSG00000121481	18.08	18.30	17.01	19.39	19.71	18.97	-0.111532242036687	4.23935744358677	0.216879486073792	0.595629129725615	1:185045363-185102608:+	RNF2	31;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000278,biological_process mitotic cell cycle;GO:0000791,cellular_component euchromatin;GO:0000792,cellular_component heterochromatin;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001739,cellular_component sex chromatin;GO:0003682,molecular_function chromatin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007281,biological_process germ cell development;GO:0008270,molecular_function zinc ion binding;GO:0009948,biological_process anterior/posterior axis specification;GO:0016567,biological_process protein ubiquitination;GO:0016574,biological_process histone ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex;GO:0035518,biological_process histone H2A monoubiquitination;GO:0036353,biological_process histone H2A-K119 monoubiquitination;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071339,cellular_component MLL1 complex;GO:0071535,molecular_function RING-like zinc finger domain binding	NA	ring finger protein 2 [Source:HGNC Symbol%3BAcc:HGNC:10061]
ENSG00000164754	145.77	148.93	146.42	148.95	166.23	154.23	-0.0780309014861461	8.16787783581424	0.216889041034382	0.595629129725615	8:116845934-116874866:-	RAD21	33;GO:0000228,cellular_component nuclear chromosome;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000798,cellular_component nuclear cohesin complex;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007131,biological_process reciprocal meiotic recombination;GO:0008278,cellular_component cohesin complex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0032403,molecular_function protein complex binding;GO:0045841,biological_process negative regulation of mitotic metaphase/anaphase transition;GO:0045876,biological_process positive regulation of sister chromatid cohesion;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051301,biological_process cell division;GO:0071168,biological_process protein localization to chromatin	SCC1, MCD1, RAD21; cohesin complex subunit SCC1; K06670	RAD21 cohesin complex component [Source:HGNC Symbol%3BAcc:HGNC:9811]
ENSG00000146085	22.60	21.87	20.51	20.27	21.47	19.91	0.0880455304067797	5.57420497398403	0.216989459099316	0.595635278760629	6:49430359-49463191:-	MUT	14;GO:0003824,molecular_function catalytic activity;GO:0004494,molecular_function methylmalonyl-CoA mutase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008152,biological_process metabolic process;GO:0009235,biological_process cobalamin metabolic process;GO:0009791,biological_process post-embryonic development;GO:0016853,molecular_function isomerase activity;GO:0016866,molecular_function intramolecular transferase activity;GO:0019626,biological_process short-chain fatty acid catabolic process;GO:0031419,molecular_function cobalamin binding;GO:0046872,molecular_function metal ion binding;GO:0050667,biological_process homocysteine metabolic process;GO:0072341,molecular_function modified amino acid binding	MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]; K01847	methylmalonyl-CoA mutase [Source:HGNC Symbol%3BAcc:HGNC:7526]
ENSG00000176410	15.00	19.31	18.13	13.69	18.68	14.00	0.183733904206884	3.49237593516786	0.217071757273085	0.595635278760629	7:73680968-73683453:-	DNAJC30	2;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol	NA	DnaJ heat shock protein family (Hsp40) member C30 [Source:HGNC Symbol%3BAcc:HGNC:16410]
ENSG00000116668	3.58	2.69	2.62	2.61	3.06	2.01	0.233325665752873	2.92854929675932	0.217074375190917	0.595635278760629	1:185157079-185291765:+	SWT1	2;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated	NA	SWT1%2C RNA endoribonuclease homolog [Source:HGNC Symbol%3BAcc:HGNC:16785]
ENSG00000281991	11.77	11.50	16.36	17.33	14.04	15.84	-0.231846509745288	2.28460952443089	0.217083219295342	0.595635278760629	16:30740380-30744281:+	TMEM265	3;GO:0009607,biological_process response to biotic stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 265 [Source:HGNC Symbol%3BAcc:HGNC:51241]
ENSG00000137752	4.00	4.28	4.11	4.24	5.19	4.86	-0.198368954863154	2.53941976724759	0.217208886618612	0.595775116252956	11:105025442-105035250:-	CASP1	50;GO:0001666,biological_process response to hypoxia;GO:0004175,molecular_function endopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0009617,biological_process response to bacterium;GO:0010506,biological_process regulation of autophagy;GO:0016485,biological_process protein processing;GO:0016540,biological_process protein autoprocessing;GO:0016787,molecular_function hydrolase activity;GO:0019900,molecular_function kinase binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0032611,biological_process interleukin-1 beta production;GO:0033198,biological_process response to ATP;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0050700,molecular_function CARD domain binding;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050717,biological_process positive regulation of interleukin-1 alpha secretion;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050727,biological_process regulation of inflammatory response;GO:0051882,biological_process mitochondrial depolarization;GO:0060081,biological_process membrane hyperpolarization;GO:0070269,biological_process pyroptosis;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071310,biological_process cellular response to organic substance;GO:0071346,biological_process cellular response to interferon-gamma;GO:0072557,cellular_component IPAF inflammasome complex;GO:0072558,cellular_component NLRP1 inflammasome complex;GO:0072559,cellular_component NLRP3 inflammasome complex;GO:0097153,molecular_function cysteine-type endopeptidase activity involved in apoptotic process;GO:0097169,cellular_component AIM2 inflammasome complex;GO:0097179,cellular_component protease inhibitor complex;GO:0097300,biological_process programmed necrotic cell death;GO:1901998,biological_process toxin transport;GO:1903265,biological_process positive regulation of tumor necrosis factor-mediated signaling pathway	CASP1; caspase 1 [EC:3.4.22.36]; K01370	caspase 1 [Source:HGNC Symbol%3BAcc:HGNC:1499]
ENSG00000184216	54.30	57.66	54.53	56.65	64.22	57.25	-0.0863213300328435	7.19018018027656	0.217230176118656	0.595775116252956	X:154010499-154019980:-	IRAK1	55;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001959,biological_process regulation of cytokine-mediated signaling pathway;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004704,molecular_function NF-kappaB-inducing kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0007254,biological_process JNK cascade;GO:0007568,biological_process aging;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0031072,molecular_function heat shock protein binding;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032496,biological_process response to lipopolysaccharide;GO:0034134,biological_process toll-like receptor 2 signaling pathway;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0034605,biological_process cellular response to heat;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0045087,biological_process innate immune response;GO:0045323,cellular_component interleukin-1 receptor complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046777,biological_process protein autophosphorylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051259,biological_process protein oligomerization;GO:0060337,biological_process type I interferon signaling pathway;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0070555,biological_process response to interleukin-1;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071456,biological_process cellular response to hypoxia	IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]; K04730	interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:6112]
ENSG00000269858	23.99	24.49	23.71	22.74	24.02	21.20	0.0986745628613501	4.93855897147382	0.217401026403439	0.595959245377844	19:40798995-40808433:+	EGLN2	22;GO:0001558,biological_process regulation of cell growth;GO:0001666,biological_process response to hypoxia;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008198,molecular_function ferrous iron binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0018401,biological_process peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0019826,molecular_function oxygen sensor activity;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0031418,molecular_function L-ascorbic acid binding;GO:0031545,molecular_function peptidyl-proline 4-dioxygenase activity;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0045454,biological_process cell redox homeostasis;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia	EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]; K09592	egl-9 family hypoxia inducible factor 2 [Source:HGNC Symbol%3BAcc:HGNC:14660]
ENSG00000169989	0.83	0.75	0.77	0.68	0.35	0.69	0.45451942977347	0.251789680169884	0.217465789347462	0.595959245377844	4:152769353-152779764:-	TIGD4	3;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	tigger transposable element derived 4 [Source:HGNC Symbol%3BAcc:HGNC:18335]
ENSG00000141873	6.77	7.20	7.67	6.69	6.00	6.67	0.170056484420243	2.90487914724075	0.217475947795481	0.595959245377844	19:2732203-2740152:-	SLC39A3	16;GO:0000902,biological_process cell morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0043029,biological_process T cell homeostasis;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0055085,biological_process transmembrane transport;GO:0060173,biological_process limb development;GO:0071577,biological_process zinc II ion transmembrane transport	NA	solute carrier family 39 member 3 [Source:HGNC Symbol%3BAcc:HGNC:17128]
ENSG00000026297	39.85	37.00	42.14	40.57	35.09	36.68	0.0975321261650513	5.69501483085985	0.217489356445793	0.595959245377844	6:166929503-166957191:-	RNASET2	19;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006401,biological_process RNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0033897,molecular_function ribonuclease T2 activity;GO:0035578,cellular_component azurophil granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	ribonuclease T2 [Source:HGNC Symbol%3BAcc:HGNC:21686]
ENSG00000127184	492.54	507.69	466.14	534.63	529.71	500.65	-0.0832245653029138	6.60278382398956	0.217566818336766	0.596039928495758	5:86617903-86620962:+	COX7C	9;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	COX7C; cytochrome c oxidase subunit 7c; K02272	cytochrome c oxidase subunit 7C [Source:HGNC Symbol%3BAcc:HGNC:2292]
ENSG00000137040	10.61	11.04	11.55	9.87	10.66	10.84	0.0925204771985363	5.16321925085798	0.217831671037268	0.596537237862316	9:6011042-6015625:-	RANBP6	12;GO:0000060,biological_process protein import into nucleus, translocation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery	NA	RAN binding protein 6 [Source:HGNC Symbol%3BAcc:HGNC:9851]
ENSG00000138286	14.26	13.47	13.02	11.66	13.63	12.76	0.111819101071751	4.53458670752948	0.217844461389662	0.596537237862316	10:73168165-73244504:+	FAM149B1	NA	NA	family with sequence similarity 149 member B1 [Source:HGNC Symbol%3BAcc:HGNC:29162]
ENSG00000150627	0.84	0.67	0.72	0.62	0.52	0.73	0.277172822861651	1.52320895283468	0.218079361626251	0.597048768386998	4:176065833-176182818:+	WDR17	3;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	WD repeat domain 17 [Source:HGNC Symbol%3BAcc:HGNC:16661]
ENSG00000107643	16.14	13.01	15.87	16.20	16.14	17.08	-0.113360026636859	4.47395109784339	0.218171850685735	0.597170271788759	10:48306638-48439360:+	MAPK8	51;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004705,molecular_function JUN kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007254,biological_process JNK cascade;GO:0007258,biological_process JUN phosphorylation;GO:0009411,biological_process response to UV;GO:0010628,biological_process positive regulation of gene expression;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0031063,biological_process regulation of histone deacetylation;GO:0031281,biological_process positive regulation of cyclase activity;GO:0032091,biological_process negative regulation of protein binding;GO:0032880,biological_process regulation of protein localization;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035033,molecular_function histone deacetylase regulator activity;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042752,biological_process regulation of circadian rhythm;GO:0042826,molecular_function histone deacetylase binding;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0048511,biological_process rhythmic process;GO:0048666,biological_process neuron development;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0051403,biological_process stress-activated MAPK cascade;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071276,biological_process cellular response to cadmium ion;GO:0090045,biological_process positive regulation of deacetylase activity;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1902595,biological_process regulation of DNA replication origin binding	JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]; K04440	mitogen-activated protein kinase 8 [Source:HGNC Symbol%3BAcc:HGNC:6881]
ENSG00000176920	1.78	1.02	1.00	0.95	1.11	0.82	0.44401599571673	0.38340882278934	0.218384759937793	0.59760020922064	19:48695970-48705950:+	FUT2	13;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008107,molecular_function galactoside 2-alpha-L-fucosyltransferase activity;GO:0008417,molecular_function fucosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0032580,cellular_component Golgi cisterna membrane;GO:0036065,biological_process fucosylation;GO:0042355,biological_process L-fucose catabolic process;GO:0070062,cellular_component extracellular exosome	FUT1_2; galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]; K00718	fucosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:4013]
ENSG00000164162	13.42	13.10	12.38	16.21	13.35	14.35	-0.163274649458063	3.17444606102476	0.218425211410138	0.59760020922064	4:144831907-145098541:-	ANAPC10	16;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070979,biological_process protein K11-linked ubiquitination;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	NA	anaphase promoting complex subunit 10 [Source:HGNC Symbol%3BAcc:HGNC:24077]
ENSG00000005810	3.39	3.05	3.26	2.71	3.05	3.35	0.103948068293126	5.46556536068881	0.218553170029094	0.597818532298621	13:77044654-77327050:-	MYCBP2	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	MYCBP2, PAM; E3 ubiquitin-protein ligase MYCBP2 [EC:2.3.2.27]; K10693	MYC binding protein 2%2C E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:23386]
ENSG00000188015	8.39	3.78	5.34	7.41	9.01	6.50	-0.334910148148527	1.1550843678848	0.218684844475059	0.597858974075246	1:153547328-153549372:-	S100A3	7;GO:0005509,molecular_function calcium ion binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0046914,molecular_function transition metal ion binding	NA	S100 calcium binding protein A3 [Source:HGNC Symbol%3BAcc:HGNC:10493]
ENSG00000160271	11.45	10.24	11.70	11.38	11.86	12.87	-0.0966450643630561	5.1883388976553	0.218712467058584	0.597858974075246	9:133097719-133149334:-	RALGDS	13;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005903,cellular_component brush border;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0030695,molecular_function GTPase regulator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050790,biological_process regulation of catalytic activity	RALGDS; ral guanine nucleotide dissociation stimulator; K08732	ral guanine nucleotide dissociation stimulator [Source:HGNC Symbol%3BAcc:HGNC:9842]
ENSG00000197063	16.86	18.48	17.42	15.56	16.07	15.92	0.155497729313446	3.04519274608964	0.218775964791275	0.597858974075246	17:81918269-81927714:-	MAFG	19;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007596,biological_process blood coagulation;GO:0010628,biological_process positive regulation of gene expression;GO:0030534,biological_process adult behavior;GO:0030641,biological_process regulation of cellular pH;GO:0042127,biological_process regulation of cell proliferation;GO:0045604,biological_process regulation of epidermal cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity	NA	MAF bZIP transcription factor G [Source:HGNC Symbol%3BAcc:HGNC:6781]
ENSG00000157350	16.21	16.75	17.03	17.40	19.29	17.88	-0.114891897117428	4.20678593679107	0.218817657556683	0.597858974075246	16:70375977-70439237:-	ST3GAL2	18;GO:0000139,cellular_component Golgi membrane;GO:0003836,molecular_function beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0006040,biological_process amino sugar metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0032580,cellular_component Golgi cisterna membrane;GO:0097503,biological_process sialylation	SIAT4B; beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B) [EC:2.4.99.4]; K03368	ST3 beta-galactoside alpha-2%2C3-sialyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:10863]
ENSG00000142528	6.52	5.43	6.63	6.35	5.12	5.53	0.147235085028404	4.02413225200618	0.218857063875165	0.597858974075246	19:50025713-50053414:+	ZNF473	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006398,biological_process mRNA 3'-end processing by stem-loop binding and cleavage;GO:0008334,biological_process histone mRNA metabolic process;GO:0015030,cellular_component Cajal body;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 473 [Source:HGNC Symbol%3BAcc:HGNC:23239]
ENSG00000108641	13.02	13.14	15.02	10.85	13.80	13.08	0.140222734914555	4.01251010110901	0.21890761500652	0.597858974075246	17:19337553-19378182:-	B9D1	20;GO:0001701,biological_process in utero embryonic development;GO:0001944,biological_process vasculature development;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007224,biological_process smoothened signaling pathway;GO:0008158,molecular_function hedgehog receptor activity;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0032880,biological_process regulation of protein localization;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0036064,cellular_component ciliary basal body;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0060271,biological_process cilium morphogenesis;GO:0060563,biological_process neuroepithelial cell differentiation;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	B9 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24123]
ENSG00000110031	49.66	48.59	51.69	56.50	48.60	55.85	-0.089816970465368	5.94696365802335	0.218948846666905	0.597858974075246	11:58526870-58578220:-	LPXN	23;GO:0002102,cellular_component podosome;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006461,biological_process protein complex assembly;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030054,cellular_component cell junction;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050859,biological_process negative regulation of B cell receptor signaling pathway;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	leupaxin [Source:HGNC Symbol%3BAcc:HGNC:14061]
ENSG00000129636	60.07	59.17	58.94	56.50	59.47	53.97	0.0803788996764606	6.76198526466722	0.218953266426011	0.597858974075246	16:47154386-47464149:-	ITFG1	4;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	integrin alpha FG-GAP repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30697]
ENSG00000175938	38.24	31.67	33.89	29.50	34.12	33.60	0.110839936733537	5.12930275292396	0.219067309542309	0.598038819738	16:30949065-30956461:+	ORAI3	6;GO:0002115,biological_process store-operated calcium entry;GO:0005515,molecular_function protein binding;GO:0015279,molecular_function store-operated calcium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070588,biological_process calcium ion transmembrane transport	ORAI3; calcium release-activated calcium channel protein 3; K16058	ORAI calcium release-activated calcium modulator 3 [Source:HGNC Symbol%3BAcc:HGNC:28185]
ENSG00000137210	89.20	93.73	80.02	96.33	99.93	87.04	-0.0978373010766562	5.94899924828092	0.219153815735887	0.598143428920308	6:10747758-10852753:+	TMEM14B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 14B [Source:HGNC Symbol%3BAcc:HGNC:21384]
ENSG00000153574	12.19	16.90	15.54	14.04	13.01	13.11	0.153786509489818	3.72952736148728	0.219253523496314	0.598150716294927	2:88691643-88750935:+	RPIA	12;GO:0004751,molecular_function ribose-5-phosphate isomerase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006014,biological_process D-ribose metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0009052,biological_process pentose-phosphate shunt, non-oxidative branch;GO:0016853,molecular_function isomerase activity;GO:0019693,biological_process ribose phosphate metabolic process;GO:0030246,molecular_function carbohydrate binding;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048029,molecular_function monosaccharide binding	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]; K01807	ribose 5-phosphate isomerase A [Source:HGNC Symbol%3BAcc:HGNC:10297]
ENSG00000167987	9.22	10.59	11.40	9.28	9.26	9.71	0.151900467321082	3.4179433459326	0.21926056969336	0.598150716294927	11:61130255-61161617:-	VPS37C	18;GO:0000813,cellular_component ESCRT I complex;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0043657,cellular_component host cell;GO:0046983,molecular_function protein dimerization activity;GO:0048306,molecular_function calcium-dependent protein binding;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus	VPS37; ESCRT-I complex subunit VPS37; K12185	VPS37C%2C ESCRT-I subunit [Source:HGNC Symbol%3BAcc:HGNC:26097]
ENSG00000132749	6.04	4.21	6.07	4.19	5.01	5.22	0.203888717306173	3.06288487446065	0.219301048083317	0.598150716294927	11:68707439-68751564:-	TESMIN	8;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006875,biological_process cellular metal ion homeostasis;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0010038,biological_process response to metal ion;GO:0030154,biological_process cell differentiation;GO:0046872,molecular_function metal ion binding	NA	testis expressed metallothionein like protein [Source:HGNC Symbol%3BAcc:HGNC:7446]
ENSG00000000419	70.79	69.97	72.35	73.18	73.01	81.44	-0.0834024068667186	6.02765278434513	0.219565660526427	0.598740892819539	20:50934866-50958555:-	DPM1	21;GO:0004169,molecular_function dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0004582,molecular_function dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005537,molecular_function mannose binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0019348,biological_process dolichol metabolic process;GO:0019673,biological_process GDP-mannose metabolic process;GO:0033185,cellular_component dolichol-phosphate-mannose synthase complex;GO:0035268,biological_process protein mannosylation;GO:0035269,biological_process protein O-linked mannosylation;GO:0043178,molecular_function alcohol binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0097502,biological_process mannosylation	DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]; K00721	dolichyl-phosphate mannosyltransferase subunit 1%2C catalytic [Source:HGNC Symbol%3BAcc:HGNC:3005]
ENSG00000011304	120.99	124.48	113.55	127.05	137.52	119.71	-0.0867983599226351	7.78479574968436	0.219757536950552	0.598931246052295	19:797074-812327:+	PTBP1	20;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006397,biological_process mRNA processing;GO:0008187,molecular_function poly-pyrimidine tract binding;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0033119,biological_process negative regulation of RNA splicing;GO:0036002,molecular_function pre-mRNA binding;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0051148,biological_process negative regulation of muscle cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0075522,biological_process IRES-dependent viral translational initiation	NA	polypyrimidine tract binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9583]
ENSG00000102897	60.23	69.20	67.68	71.60	66.43	75.49	-0.108743874735214	4.90346661127984	0.219762243549513	0.598931246052295	16:20899867-20925006:+	LYRM1	4;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0030496,cellular_component midbody	NA	LYR motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25074]
ENSG00000063244	97.78	119.71	106.27	114.31	127.23	108.92	-0.103820084891523	7.42885264381809	0.219786791748966	0.598931246052295	19:55654145-55674715:+	U2AF2	27;GO:0000243,cellular_component commitment complex;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008187,molecular_function poly-pyrimidine tract binding;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0019899,molecular_function enzyme binding;GO:0030628,molecular_function pre-mRNA 3'-splice site binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0033120,biological_process positive regulation of RNA splicing;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0071004,cellular_component U2-type prespliceosome;GO:0089701,cellular_component U2AF;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	U2AF2; splicing factor U2AF 65 kDa subunit; K12837	U2 small nuclear RNA auxiliary factor 2 [Source:HGNC Symbol%3BAcc:HGNC:23156]
ENSG00000135537	3.14	4.64	5.11	5.91	3.89	5.64	-0.254828367311437	2.83937920675418	0.219828466689298	0.598931246052295	6:108294893-108526796:+	AFG1L	10;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0007005,biological_process mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0035694,biological_process mitochondrial protein catabolic process	NA	AFG1 like ATPase [Source:HGNC Symbol%3BAcc:HGNC:16411]
ENSG00000181894	8.57	10.36	10.57	9.92	11.82	10.96	-0.14152697608553	4.08508482761828	0.219912900970648	0.599029809029768	19:58126251-58155110:-	ZNF329	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 329 [Source:HGNC Symbol%3BAcc:HGNC:14209]
ENSG00000076650	5.51	5.27	4.90	4.58	5.00	4.91	0.125611632993671	3.82715292680085	0.219965949971052	0.599042855855785	19:33080879-33130542:+	GPATCH1	4;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0006397,biological_process mRNA processing;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	G-patch domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24658]
ENSG00000064270	0.94	1.08	0.88	1.28	1.11	1.08	-0.259820510056407	1.7031973872518	0.220146784170826	0.599312781337342	16:84368526-84464187:+	ATP2C2	21;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034220,biological_process ion transmembrane transport;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061180,biological_process mammary gland epithelium development;GO:0070588,biological_process calcium ion transmembrane transport;GO:0072661,biological_process protein targeting to plasma membrane;GO:0090280,biological_process positive regulation of calcium ion import;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	NA	ATPase secretory pathway Ca2+ transporting 2 [Source:HGNC Symbol%3BAcc:HGNC:29103]
ENSG00000004897	38.08	36.31	36.86	38.89	38.95	40.52	-0.077052245984019	6.63015807318117	0.220175825604631	0.599312781337342	17:47117702-47189422:-	CDC27	23;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005876,cellular_component spindle microtubule;GO:0007091,biological_process metaphase/anaphase transition of mitotic cell cycle;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0019903,molecular_function protein phosphatase binding;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC3, CDC27; anaphase-promoting complex subunit 3; K03350	cell division cycle 27 [Source:HGNC Symbol%3BAcc:HGNC:1728]
ENSG00000185019	7.48	6.42	8.07	8.03	8.18	8.32	-0.136194164241662	3.67735922429152	0.22023545651958	0.599312781337342	20:3107572-3160196:-	UBOX5	13;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005925,cellular_component focal adhesion;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	UBOX5, UIP5; U-box domain-containing protein 5; K10600	U-box domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:17777]
ENSG00000171100	6.40	6.44	6.75	5.88	6.04	6.06	0.136937803955428	3.52113661586248	0.220258189677028	0.599312781337342	X:150568618-150673322:+	MTM1	39;GO:0001726,cellular_component ruffle;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019215,molecular_function intermediate filament binding;GO:0030175,cellular_component filopodium;GO:0031674,cellular_component I band;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042995,cellular_component cell projection;GO:0044088,biological_process regulation of vacuole organization;GO:0045109,biological_process intermediate filament organization;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048311,biological_process mitochondrion distribution;GO:0048633,biological_process positive regulation of skeletal muscle tissue growth;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0070062,cellular_component extracellular exosome;GO:0070584,biological_process mitochondrion morphogenesis;GO:1902902,biological_process negative regulation of autophagosome assembly	MTM1; myotubularin [EC:3.1.3.64 3.1.3.95]; K01108	myotubularin 1 [Source:HGNC Symbol%3BAcc:HGNC:7448]
ENSG00000182670	52.18	55.15	52.53	48.02	54.64	49.60	0.0818071262399744	8.3370822265256	0.220355980197269	0.599447464867127	21:37073225-37203112:+	TTC3	10;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0070936,biological_process protein K48-linked ubiquitination	NA	tetratricopeptide repeat domain 3 [Source:HGNC Symbol%3BAcc:HGNC:12393]
ENSG00000164744	0.86	0.95	0.96	0.97	0.46	0.59	0.454747964275104	0.252247974909047	0.220764857184074	0.600428170952215	7:47987147-48029119:-	SUN3	9;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0006998,biological_process nuclear envelope organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034993,cellular_component LINC complex;GO:0043495,molecular_function protein anchor;GO:0090286,biological_process cytoskeletal anchoring at nuclear membrane	NA	Sad1 and UNC84 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:22429]
ENSG00000185164	18.17	17.18	17.69	17.21	17.74	15.42	0.087635341304252	6.46962416797108	0.221017883992542	0.600827926504259	16:18417324-18562211:-	NOMO2	7;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0031648,biological_process protein destabilization	NA	NODAL modulator 2 [Source:HGNC Symbol%3BAcc:HGNC:22652]
ENSG00000177706	97.84	81.87	93.72	100.98	89.82	104.07	-0.0958404261163812	7.37782964329454	0.22105587434877	0.600827926504259	7:192968-260745:+	FAM20C	30;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030145,molecular_function manganese ion binding;GO:0030501,biological_process positive regulation of bone mineralization;GO:0031214,biological_process biomineral tissue development;GO:0036179,biological_process osteoclast maturation;GO:0040036,biological_process regulation of fibroblast growth factor receptor signaling pathway;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051174,biological_process regulation of phosphorus metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0070166,biological_process enamel mineralization;GO:0071895,biological_process odontoblast differentiation;GO:0097187,biological_process dentinogenesis	NA	FAM20C%2C golgi associated secretory pathway kinase [Source:HGNC Symbol%3BAcc:HGNC:22140]
ENSG00000184557	18.31	17.84	15.81	17.86	13.93	15.11	0.158013287839396	3.49285727935553	0.221058775946243	0.600827926504259	17:78356777-78360077:-	SOCS3	29;GO:0001784,molecular_function phosphotyrosine binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007259,biological_process JAK-STAT cascade;GO:0009968,biological_process negative regulation of signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0045595,biological_process regulation of cell differentiation;GO:0045597,biological_process positive regulation of cell differentiation;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0050728,biological_process negative regulation of inflammatory response;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0060670,biological_process branching involved in labyrinthine layer morphogenesis;GO:0060674,biological_process placenta blood vessel development;GO:0060707,biological_process trophoblast giant cell differentiation;GO:0060708,biological_process spongiotrophoblast differentiation;GO:1990830,biological_process cellular response to leukemia inhibitory factor	SOCS3, CIS3; suppressor of cytokine signaling 3; K04696	suppressor of cytokine signaling 3 [Source:HGNC Symbol%3BAcc:HGNC:19391]
ENSG00000017260	69.06	66.70	67.19	61.47	68.34	64.07	0.0779537761889461	7.62145649144229	0.221140549104886	0.600827926504259	3:130850594-131016712:+	ATP2C1	25;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0004871,molecular_function signal transducer activity;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005524,molecular_function ATP binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007165,biological_process signal transduction;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016787,molecular_function hydrolase activity;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0032468,biological_process Golgi calcium ion homeostasis;GO:0032472,biological_process Golgi calcium ion transport;GO:0034220,biological_process ion transmembrane transport;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding;GO:0070588,biological_process calcium ion transmembrane transport;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	NA	ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol%3BAcc:HGNC:13211]
ENSG00000114867	102.62	113.27	102.50	100.53	106.13	96.44	0.0823440595555735	8.97986941759313	0.221153854523319	0.600827926504259	3:184314494-184335358:+	EIF4G1	47;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0001662,biological_process behavioral fear response;GO:0002191,biological_process cap-dependent translational initiation;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0007005,biological_process mitochondrion organization;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0008190,molecular_function eukaryotic initiation factor 4E binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010507,biological_process negative regulation of autophagy;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030307,biological_process positive regulation of cell growth;GO:0031369,molecular_function translation initiation factor binding;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032502,biological_process developmental process;GO:0032947,molecular_function protein complex scaffold;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034645,biological_process cellular macromolecule biosynthetic process;GO:0043488,biological_process regulation of mRNA stability;GO:0045296,molecular_function cadherin binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0080135,biological_process regulation of cellular response to stress;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1901215,biological_process negative regulation of neuron death;GO:1905537,biological_process positive regulation of eukaryotic translation initiation factor 4F complex assembly;GO:1905606,biological_process regulation of presynapse assembly;GO:1905612,biological_process positive regulation of mRNA cap binding;GO:1905618,biological_process positive regulation of miRNA mediated inhibition of translation;GO:1905696,biological_process regulation of polysome binding;GO:2000507,biological_process positive regulation of energy homeostasis	EIF4G; translation initiation factor 4G; K03260	eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:3296]
ENSG00000151065	8.19	8.24	9.75	9.04	9.90	9.83	-0.121631732832694	4.24810668229389	0.221253310802173	0.600966596714962	12:1946053-2004535:-	DCP1B	16;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008047,molecular_function enzyme activator activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030234,molecular_function enzyme regulator activity;GO:0031087,biological_process deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]; K12611	decapping mRNA 1B [Source:HGNC Symbol%3BAcc:HGNC:24451]
ENSG00000179583	0.34	0.25	0.47	0.24	0.22	0.34	0.440072469847108	0.410881136640503	0.221489396291986	0.601476236309872	16:10866221-10932281:+	CIITA	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007568,biological_process aging;GO:0008022,molecular_function protein C-terminus binding;GO:0009986,cellular_component cell surface;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0032403,molecular_function protein complex binding;GO:0032966,biological_process negative regulation of collagen biosynthetic process;GO:0033613,molecular_function activating transcription factor binding;GO:0034341,biological_process response to interferon-gamma;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045345,biological_process positive regulation of MHC class I biosynthetic process;GO:0045348,biological_process positive regulation of MHC class II biosynthetic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046677,biological_process response to antibiotic;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0071257,biological_process cellular response to electrical stimulus;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071360,biological_process cellular response to exogenous dsRNA	CIITA; MHC class II transactivator [EC:2.7.11.1]; K08060	class II major histocompatibility complex transactivator [Source:HGNC Symbol%3BAcc:HGNC:7067]
ENSG00000123179	38.49	41.80	42.61	37.30	38.85	39.89	0.0920711834068372	5.0956362040226	0.221560032185257	0.601528958934665	13:49660722-49691475:-	EBPL	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016125,biological_process sterol metabolic process;GO:0047750,molecular_function cholestenol delta-isomerase activity	NA	emopamil binding protein like [Source:HGNC Symbol%3BAcc:HGNC:18061]
ENSG00000167779	98.40	95.44	85.99	84.88	87.05	93.46	0.0871998485431758	6.14714833209799	0.221605730218982	0.601528958934665	12:53097435-53102345:+	IGFBP6	17;GO:0001558,biological_process regulation of cell growth;GO:0005102,molecular_function receptor binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0007165,biological_process signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0019838,molecular_function growth factor binding;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0031995,molecular_function insulin-like growth factor II binding;GO:0042568,cellular_component insulin-like growth factor binary complex;GO:0043567,biological_process regulation of insulin-like growth factor receptor signaling pathway;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	insulin like growth factor binding protein 6 [Source:HGNC Symbol%3BAcc:HGNC:5475]
ENSG00000100056	10.51	10.36	10.80	12.00	11.49	11.13	-0.114110503637599	4.0518788971879	0.221678394062304	0.601594644839391	22:19130278-19144684:-	ESS2	9;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0007399,biological_process nervous system development;GO:0008380,biological_process RNA splicing;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	ess-2 splicing factor homolog [Source:HGNC Symbol%3BAcc:HGNC:16817]
ENSG00000168078	40.30	42.28	33.45	41.67	45.70	39.14	-0.116005686514492	5.34013696613735	0.221744217967753	0.601641743745076	8:27809619-27838095:-	PBK	17;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032873,biological_process negative regulation of stress-activated MAPK cascade;GO:0034644,biological_process cellular response to UV;GO:0050728,biological_process negative regulation of inflammatory response	NA	PDZ binding kinase [Source:HGNC Symbol%3BAcc:HGNC:18282]
ENSG00000164096	94.17	99.09	86.05	79.01	100.23	80.92	0.112876399189744	5.74898707390684	0.221803034539748	0.601669813754783	4:119296418-119304445:-	C4orf3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 4 open reading frame 3 [Source:HGNC Symbol%3BAcc:HGNC:19225]
ENSG00000171298	21.42	20.83	23.82	20.41	20.86	21.55	0.0866759122851214	5.94526623710138	0.22202240042827	0.601905879846166	17:80101555-80119879:+	GAA	38;GO:0000023,biological_process maltose metabolic process;GO:0002026,biological_process regulation of the force of heart contraction;GO:0002086,biological_process diaphragm contraction;GO:0003007,biological_process heart morphogenesis;GO:0003824,molecular_function catalytic activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004558,molecular_function alpha-1,4-glucosidase activity;GO:0004574,molecular_function oligo-1,6-glucosidase activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005980,biological_process glycogen catabolic process;GO:0005985,biological_process sucrose metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006941,biological_process striated muscle contraction;GO:0007040,biological_process lysosome organization;GO:0007626,biological_process locomotory behavior;GO:0008152,biological_process metabolic process;GO:0009888,biological_process tissue development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030246,molecular_function carbohydrate binding;GO:0032450,molecular_function maltose alpha-glucosidase activity;GO:0035577,cellular_component azurophil granule membrane;GO:0043181,biological_process vacuolar sequestering;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0050884,biological_process neuromuscular process controlling posture;GO:0050885,biological_process neuromuscular process controlling balance;GO:0060048,biological_process cardiac muscle contraction;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane	GAA; lysosomal alpha-glucosidase [EC:3.2.1.20]; K12316	glucosidase alpha%2C acid [Source:HGNC Symbol%3BAcc:HGNC:4065]
ENSG00000077235	19.62	21.26	19.80	18.38	20.44	18.89	0.0830151635568294	6.98491947921935	0.222054518133546	0.601905879846166	16:27459554-27549913:-	GTF3C1	20;GO:0000127,cellular_component transcription factor TFIIIC complex;GO:0000995,molecular_function transcription factor activity, core RNA polymerase III binding;GO:0001002,molecular_function RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003,molecular_function RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0001007,molecular_function transcription factor activity, RNA polymerase III transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0006384,biological_process transcription initiation from RNA polymerase III promoter;GO:0009303,biological_process rRNA transcription;GO:0009304,biological_process tRNA transcription;GO:0016020,cellular_component membrane;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042791,biological_process 5S class rRNA transcription from RNA polymerase III type 1 promoter;GO:0042797,biological_process tRNA transcription from RNA polymerase III promoter	NA	general transcription factor IIIC subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4664]
ENSG00000145604	22.04	21.20	21.57	20.42	22.07	18.37	0.105214965374254	4.95548999272163	0.222070701955397	0.601905879846166	5:36151988-36184319:+	SKP2	27;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008283,biological_process cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051726,biological_process regulation of cell cycle;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071460,biological_process cellular response to cell-matrix adhesion;GO:1902916,biological_process positive regulation of protein polyubiquitination	SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2); K03875	S-phase kinase associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:10901]
ENSG00000186153	7.18	7.68	6.43	7.83	8.15	7.55	-0.13843156586069	3.7164102472674	0.222116061124558	0.601905879846166	16:78099412-79212667:+	WWOX	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001649,biological_process osteoblast differentiation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006915,biological_process apoptotic process;GO:0008202,biological_process steroid metabolic process;GO:0016055,biological_process Wnt signaling pathway;GO:0016491,molecular_function oxidoreductase activity;GO:0019899,molecular_function enzyme binding;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0048037,molecular_function cofactor binding;GO:0048705,biological_process skeletal system morphogenesis;GO:0050662,molecular_function coenzyme binding;GO:0055114,biological_process oxidation-reduction process;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	WW domain containing oxidoreductase [Source:HGNC Symbol%3BAcc:HGNC:12799]
ENSG00000130299	8.38	7.29	7.78	6.85	7.11	7.67	0.132931197364755	3.75269692594507	0.222162179491681	0.601905879846166	19:17334919-17342735:+	GTPBP3	8;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing	NA	GTP binding protein 3 (mitochondrial) [Source:HGNC Symbol%3BAcc:HGNC:14880]
ENSG00000002834	116.81	121.11	113.11	123.99	122.04	127.16	-0.0778384493939571	6.82714273152181	0.222180999069937	0.601905879846166	17:38869858-38921770:+	LASP1	17;GO:0003779,molecular_function actin binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0009967,biological_process positive regulation of signal transduction;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0034220,biological_process ion transmembrane transport;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	NA	LIM and SH3 protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6513]
ENSG00000144655	3.92	5.52	4.50	4.24	3.30	4.58	0.196968169221903	2.95759857022135	0.222231442945351	0.601911172001013	3:39141854-39154562:-	CSRNP1	17;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0009791,biological_process post-embryonic development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048705,biological_process skeletal system morphogenesis;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis	NA	cysteine and serine rich nuclear protein 1 [Source:HGNC Symbol%3BAcc:HGNC:14300]
ENSG00000277586	49.86	56.38	45.90	43.80	50.75	48.30	0.0999092736790783	6.32508972962283	0.222404134195377	0.602133976096788	8:24950954-24957110:-	NEFL	49;GO:0000165,biological_process MAPK cascade;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0005883,cellular_component neurofilament;GO:0008022,molecular_function protein C-terminus binding;GO:0008089,biological_process anterograde axonal transport;GO:0008090,biological_process retrograde axonal transport;GO:0009636,biological_process response to toxic substance;GO:0010033,biological_process response to organic substance;GO:0014012,biological_process peripheral nervous system axon regeneration;GO:0019896,biological_process axonal transport of mitochondrion;GO:0019904,molecular_function protein domain specific binding;GO:0021510,biological_process spinal cord development;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030674,molecular_function protein binding, bridging;GO:0031133,biological_process regulation of axon diameter;GO:0033596,cellular_component TSC1-TSC2 complex;GO:0033693,biological_process neurofilament bundle assembly;GO:0040011,biological_process locomotion;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043209,cellular_component myelin sheath;GO:0043274,molecular_function phospholipase binding;GO:0043434,biological_process response to peptide hormone;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045105,biological_process intermediate filament polymerization or depolymerization;GO:0045109,biological_process intermediate filament organization;GO:0045110,biological_process intermediate filament bundle assembly;GO:0046982,molecular_function protein heterodimerization activity;GO:0048812,biological_process neuron projection morphogenesis;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051258,biological_process protein polymerization;GO:0051412,biological_process response to corticosterone;GO:0060052,biological_process neurofilament cytoskeleton organization;GO:0061564,biological_process axon development;GO:1903935,biological_process response to sodium arsenite;GO:1903937,biological_process response to acrylamide;GO:1904115,cellular_component axon cytoplasm	NEFL, NF-L; neurofilament light polypeptide; K04572	neurofilament light [Source:HGNC Symbol%3BAcc:HGNC:7739]
ENSG00000108773	29.86	29.10	34.10	28.61	29.29	30.37	0.0897726814826702	6.2509191651078	0.222410721050816	0.602133976096788	17:42113107-42121358:-	KAT2A	59;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000790,cellular_component nuclear chromatin;GO:0001701,biological_process in utero embryonic development;GO:0001756,biological_process somitogenesis;GO:0001843,biological_process neural tube closure;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0008080,molecular_function N-acetyltransferase activity;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0010484,molecular_function H3 histone acetyltransferase activity;GO:0014070,biological_process response to organic cyclic compound;GO:0016032,biological_process viral process;GO:0016407,molecular_function acetyltransferase activity;GO:0016573,biological_process histone acetylation;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019903,molecular_function protein phosphatase binding;GO:0021537,biological_process telencephalon development;GO:0022037,biological_process metencephalon development;GO:0030901,biological_process midbrain development;GO:0030914,cellular_component STAGA complex;GO:0031346,biological_process positive regulation of cell projection organization;GO:0031647,biological_process regulation of protein stability;GO:0031667,biological_process response to nutrient levels;GO:0033276,cellular_component transcription factor TFTC complex;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035264,biological_process multicellular organism growth;GO:0035948,biological_process positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043966,biological_process histone H3 acetylation;GO:0043983,biological_process histone H4-K12 acetylation;GO:0043997,molecular_function histone acetyltransferase activity (H4-K12 specific);GO:0044154,biological_process histone H3-K14 acetylation;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0048312,biological_process intracellular distribution of mitochondria;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071929,biological_process alpha-tubulin acetylation;GO:0072686,cellular_component mitotic spindle;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding	PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]; K06062	lysine acetyltransferase 2A [Source:HGNC Symbol%3BAcc:HGNC:4201]
ENSG00000087077	82.97	76.58	75.03	72.16	79.18	71.68	0.0854114472209261	6.88342977487721	0.22249001364017	0.602217300330447	7:100867137-100873454:+	TRIP6	20;GO:0003723,molecular_function RNA binding;GO:0005149,molecular_function interleukin-1 receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007155,biological_process cell adhesion;GO:0008588,biological_process release of cytoplasmic sequestered NF-kappaB;GO:0019900,molecular_function kinase binding;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0045323,cellular_component interleukin-1 receptor complex;GO:0046872,molecular_function metal ion binding;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0048041,biological_process focal adhesion assembly	NA	thyroid hormone receptor interactor 6 [Source:HGNC Symbol%3BAcc:HGNC:12311]
ENSG00000146802	13.11	13.35	11.83	11.46	12.37	12.04	0.102512508997487	4.69861308656889	0.222624950704348	0.602451169194041	7:112762381-112790592:-	TMEM168	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle	NA	transmembrane protein 168 [Source:HGNC Symbol%3BAcc:HGNC:25826]
ENSG00000103429	50.86	52.07	46.97	51.25	55.53	53.24	-0.0841129384413205	6.18383137986971	0.222749463545511	0.602553508388757	16:14632814-14669236:+	BFAR	20;GO:0000209,biological_process protein polyubiquitination;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030674,molecular_function protein binding, bridging;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0089720,molecular_function caspase binding;GO:1903895,biological_process negative regulation of IRE1-mediated unfolded protein response	NA	bifunctional apoptosis regulator [Source:HGNC Symbol%3BAcc:HGNC:17613]
ENSG00000146707	6.66	6.81	7.34	8.37	7.65	7.63	-0.171111234917121	2.79214872143298	0.222759852573593	0.602553508388757	7:76609985-76627261:-	POMZP3	10;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0008150,biological_process biological_process;GO:0031012,cellular_component extracellular matrix;GO:0031965,cellular_component nuclear membrane;GO:0032190,molecular_function acrosin binding;GO:0035803,biological_process egg coat formation;GO:2000344,biological_process positive regulation of acrosome reaction	NA	POM121 and ZP3 fusion [Source:HGNC Symbol%3BAcc:HGNC:9203]
ENSG00000134056	28.57	26.60	30.25	32.95	30.68	32.09	-0.146403229873788	3.25032532621455	0.222985765574181	0.603033182586561	5:69217759-69230129:+	MRPS36	10;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0009353,cellular_component mitochondrial oxoglutarate dehydrogenase complex;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S36 [Source:HGNC Symbol%3BAcc:HGNC:16631]
ENSG00000183527	56.91	51.70	54.03	49.08	50.33	54.87	0.0899833189190118	5.52047154305841	0.223424032558068	0.604086803777672	21:39174768-39183851:-	PSMG1	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0021930,biological_process cerebellar granule cell precursor proliferation;GO:0043248,biological_process proteasome assembly;GO:0070628,molecular_function proteasome binding;GO:0080129,biological_process proteasome core complex assembly	NA	proteasome assembly chaperone 1 [Source:HGNC Symbol%3BAcc:HGNC:3043]
ENSG00000057608	213.15	224.98	220.01	230.80	228.62	237.78	-0.0717682780293567	8.29812634843965	0.223622873819515	0.604492755383631	10:5765222-5842132:-	GDI2	26;GO:0003723,molecular_function RNA binding;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005093,molecular_function Rab GDP-dissociation inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016491,molecular_function oxidoreductase activity;GO:0031267,molecular_function small GTPase binding;GO:0031982,cellular_component vesicle;GO:0034774,cellular_component secretory granule lumen;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050790,biological_process regulation of catalytic activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0055114,biological_process oxidation-reduction process;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	NA	GDP dissociation inhibitor 2 [Source:HGNC Symbol%3BAcc:HGNC:4227]
ENSG00000158019	63.64	60.46	57.28	63.27	65.28	64.78	-0.0801503260345567	6.63429596703096	0.22384652764186	0.604791982414275	2:27889940-28338901:+	BABAM2	26;GO:0000152,cellular_component nuclear ubiquitin ligase complex;GO:0000268,molecular_function peroxisome targeting sequence binding;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0010212,biological_process response to ionizing radiation;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031593,molecular_function polyubiquitin binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045739,biological_process positive regulation of DNA repair;GO:0051301,biological_process cell division;GO:0070531,cellular_component BRCA1-A complex;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070552,cellular_component BRISC complex	BRE, BRCC45; BRCA1-A complex subunit BRE; K12173	BRISC and BRCA1 A complex member 2 [Source:HGNC Symbol%3BAcc:HGNC:1106]
ENSG00000165752	19.33	18.46	18.61	21.37	19.17	20.00	-0.0892246236736706	5.26465023279337	0.223929306630311	0.604791982414275	10:132207491-132331847:-	STK32C	12;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	serine/threonine kinase 32C [Source:HGNC Symbol%3BAcc:HGNC:21332]
ENSG00000123146	48.84	44.81	50.93	55.63	47.65	52.03	-0.090324968738026	7.0380985941488	0.223981988288257	0.604791982414275	19:14380500-14408725:+	ADGRE5	23;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	adhesion G protein-coupled receptor E5 [Source:HGNC Symbol%3BAcc:HGNC:1711]
ENSG00000204160	11.27	12.47	11.38	12.14	14.25	12.33	-0.133395800101031	3.90168744800939	0.224123689587331	0.604791982414275	1:26826709-26857602:+	ZDHHC18	9;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0034613,biological_process cellular protein localization	NA	zinc finger DHHC-type containing 18 [Source:HGNC Symbol%3BAcc:HGNC:20712]
ENSG00000023191	63.30	65.11	63.52	60.71	62.16	60.64	0.0758644324324221	6.64007134630022	0.224129175353233	0.604791982414275	11:494511-507300:-	RNH1	10;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006402,biological_process mRNA catabolic process;GO:0008428,molecular_function ribonuclease inhibitor activity;GO:0032311,cellular_component angiogenin-PRI complex;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045765,biological_process regulation of angiogenesis;GO:0070062,cellular_component extracellular exosome	NA	ribonuclease/angiogenin inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:10074]
ENSG00000105552	39.65	42.72	39.93	39.73	40.09	36.24	0.0853763416546437	5.83517553008768	0.224133432840645	0.604791982414275	19:48795061-48811029:-	BCAT2	23;GO:0003824,molecular_function catalytic activity;GO:0004084,molecular_function branched-chain-amino-acid transaminase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006549,biological_process isoleucine metabolic process;GO:0006550,biological_process isoleucine catabolic process;GO:0006551,biological_process leucine metabolic process;GO:0006573,biological_process valine metabolic process;GO:0008152,biological_process metabolic process;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009081,biological_process branched-chain amino acid metabolic process;GO:0009082,biological_process branched-chain amino acid biosynthetic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0009098,biological_process leucine biosynthetic process;GO:0009099,biological_process valine biosynthetic process;GO:0010817,biological_process regulation of hormone levels;GO:0016740,molecular_function transferase activity;GO:0052654,molecular_function L-leucine transaminase activity;GO:0052655,molecular_function L-valine transaminase activity;GO:0052656,molecular_function L-isoleucine transaminase activity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]; K00826	branched chain amino acid transaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:977]
ENSG00000100644	254.20	238.01	273.56	242.78	229.23	256.30	0.0844698965120972	9.33173145956689	0.224164394288632	0.604791982414275	14:61695512-61748259:+	HIF1A	125;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0001568,biological_process blood vessel development;GO:0001666,biological_process response to hypoxia;GO:0001755,biological_process neural crest cell migration;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001892,biological_process embryonic placenta development;GO:0001922,biological_process B-1 B cell homeostasis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001944,biological_process vasculature development;GO:0001947,biological_process heart looping;GO:0002039,molecular_function p53 binding;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002248,biological_process connective tissue replacement involved in inflammatory response wound healing;GO:0003151,biological_process outflow tract morphogenesis;GO:0003208,biological_process cardiac ventricle morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006089,biological_process lactate metabolic process;GO:0006110,biological_process regulation of glycolytic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007165,biological_process signal transduction;GO:0007595,biological_process lactation;GO:0008134,molecular_function transcription factor binding;GO:0008542,biological_process visual learning;GO:0010039,biological_process response to iron ion;GO:0010468,biological_process regulation of gene expression;GO:0010508,biological_process positive regulation of autophagy;GO:0010573,biological_process vascular endothelial growth factor production;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010628,biological_process positive regulation of gene expression;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010870,biological_process positive regulation of receptor biosynthetic process;GO:0014850,biological_process response to muscle activity;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0019896,biological_process axonal transport of mitochondrion;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0021502,biological_process neural fold elevation formation;GO:0021987,biological_process cerebral cortex development;GO:0030154,biological_process cell differentiation;GO:0030279,biological_process negative regulation of ossification;GO:0030502,biological_process negative regulation of bone mineralization;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031514,cellular_component motile cilium;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032364,biological_process oxygen homeostasis;GO:0032722,biological_process positive regulation of chemokine production;GO:0032909,biological_process regulation of transforming growth factor beta2 production;GO:0032963,biological_process collagen metabolic process;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035162,biological_process embryonic hemopoiesis;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042127,biological_process regulation of cell proliferation;GO:0042541,biological_process hemoglobin biosynthetic process;GO:0042593,biological_process glucose homeostasis;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0042826,molecular_function histone deacetylase binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043619,biological_process regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043687,biological_process post-translational protein modification;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045821,biological_process positive regulation of glycolytic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045926,biological_process negative regulation of growth;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046886,biological_process positive regulation of hormone biosynthetic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048514,biological_process blood vessel morphogenesis;GO:0048546,biological_process digestive tract morphogenesis;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050790,biological_process regulation of catalytic activity;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051216,biological_process cartilage development;GO:0051541,biological_process elastin metabolic process;GO:0051879,molecular_function Hsp90 protein binding;GO:0060574,biological_process intestinal epithelial cell maturation;GO:0061030,biological_process epithelial cell differentiation involved in mammary gland alveolus development;GO:0061072,biological_process iris morphogenesis;GO:0061298,biological_process retina vasculature development in camera-type eye;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061419,biological_process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070101,biological_process positive regulation of chemokine-mediated signaling pathway;GO:0070243,biological_process regulation of thymocyte apoptotic process;GO:0070244,biological_process negative regulation of thymocyte apoptotic process;GO:0070888,molecular_function E-box binding;GO:0071347,biological_process cellular response to interleukin-1;GO:0071456,biological_process cellular response to hypoxia;GO:0071542,biological_process dopaminergic neuron differentiation;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:0097411,biological_process hypoxia-inducible factor-1alpha signaling pathway;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903377,biological_process negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903599,biological_process positive regulation of mitophagy;GO:1903715,biological_process regulation of aerobic respiration;GO:1904115,cellular_component axon cytoplasm;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2001054,biological_process negative regulation of mesenchymal cell apoptotic process	HIF1A; hypoxia-inducible factor 1 alpha; K08268	hypoxia inducible factor 1 alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:4910]
ENSG00000017797	57.87	60.23	54.02	62.37	59.59	61.44	-0.0812324993382617	6.88255940366076	0.224201248158864	0.604791982414275	18:9475008-9538116:+	RALBP1	18;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006935,biological_process chemotaxis;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0017160,molecular_function Ral GTPase binding;GO:0022857,molecular_function transmembrane transporter activity;GO:0043087,biological_process regulation of GTPase activity;GO:0043492,molecular_function ATPase activity, coupled to movement of substances;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048365,molecular_function Rac GTPase binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0055085,biological_process transmembrane transport	RALBP1; RalA-binding protein 1; K08773	ralA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9841]
ENSG00000156853	3.91	3.82	3.88	4.09	4.25	4.92	-0.181955979945947	2.67624090134917	0.22421794090752	0.604791982414275	16:30602557-30624012:-	ZNF689	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 689 [Source:HGNC Symbol%3BAcc:HGNC:25173]
ENSG00000136682	29.05	26.00	22.77	27.16	30.21	27.50	-0.112462872133342	5.07377905065372	0.224234324735408	0.604791982414275	2:113437690-113496189:+	CBWD2	2;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding	NA	COBW domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:17907]
ENSG00000112365	5.57	6.40	6.72	5.84	5.04	6.09	0.146701453675222	3.65120616916354	0.224371263062969	0.604791982414275	6:109462593-109483237:-	ZBTB24	8;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 24 [Source:HGNC Symbol%3BAcc:HGNC:21143]
ENSG00000064225	8.45	7.48	6.12	7.43	5.41	6.64	0.189743709401083	3.32881212514877	0.224414265522197	0.604791982414275	3:98732235-98821201:+	ST3GAL6	18;GO:0000139,cellular_component Golgi membrane;GO:0003836,molecular_function beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0006664,biological_process glycolipid metabolic process;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0052798,molecular_function beta-galactoside alpha-2,3-sialyltransferase activity;GO:0070062,cellular_component extracellular exosome;GO:0071354,biological_process cellular response to interleukin-6;GO:0097503,biological_process sialylation	SIAT10, ST3GAL6; neolactotetraosylceramide alpha-2,3-sialyltransferase (sialyltransferase 10) [EC:2.4.99.6]; K03792	ST3 beta-galactoside alpha-2%2C3-sialyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:18080]
ENSG00000006432	6.08	6.39	7.34	6.45	5.67	6.26	0.120910842490285	4.50014946057446	0.224417099485585	0.604791982414275	14:70722525-70809534:-	MAP3K9	28;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004706,molecular_function JUN kinase kinase kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007256,biological_process activation of JNKK activity;GO:0007257,biological_process activation of JUN kinase activity;GO:0008219,biological_process cell death;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046777,biological_process protein autophosphorylation	MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]; K04417	mitogen-activated protein kinase kinase kinase 9 [Source:HGNC Symbol%3BAcc:HGNC:6861]
ENSG00000113119	5.80	6.77	6.00	6.50	6.43	7.96	-0.169083508796919	3.33379116480709	0.224475521416474	0.604791982414275	5:140639426-140645408:+	TMCO6	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane and coiled-coil domains 6 [Source:HGNC Symbol%3BAcc:HGNC:28814]
ENSG00000104872	42.33	37.95	40.90	47.34	39.31	44.27	-0.0971080212368223	5.56776913717385	0.224519260741867	0.604791982414275	19:49446297-49453497:-	PIH1D1	31;GO:0000492,biological_process box C/D snoRNP assembly;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0019901,molecular_function protein kinase binding;GO:0030855,biological_process epithelial cell differentiation;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0042393,molecular_function histone binding;GO:0048254,biological_process snoRNA localization;GO:0051117,molecular_function ATPase binding;GO:0051219,molecular_function phosphoprotein binding;GO:0051569,biological_process regulation of histone H3-K4 methylation;GO:0070761,cellular_component pre-snoRNP complex;GO:0071169,biological_process establishment of protein localization to chromatin;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090240,biological_process positive regulation of histone H4 acetylation;GO:0097255,cellular_component R2TP complex;GO:1900110,biological_process negative regulation of histone H3-K9 dimethylation;GO:1900113,biological_process negative regulation of histone H3-K9 trimethylation;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1902661,biological_process positive regulation of glucose mediated signaling pathway;GO:1904263,biological_process positive regulation of TORC1 signaling;GO:2000617,biological_process positive regulation of histone H3-K9 acetylation;GO:2000619,biological_process negative regulation of histone H4-K16 acetylation;GO:2001268,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	NA	PIH1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26075]
ENSG00000173930	4.45	6.60	4.20	5.03	7.23	5.54	-0.222016530224229	3.58907022854559	0.224581454960765	0.604791982414275	5:102233985-102296549:-	SLCO4C1	17;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0015347,molecular_function sodium-independent organic anion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0030154,biological_process cell differentiation;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0043252,biological_process sodium-independent organic anion transport;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	solute carrier organic anion transporter family member 4C1 [Source:HGNC Symbol%3BAcc:HGNC:23612]
ENSG00000065243	25.09	21.42	23.55	23.16	25.84	26.34	-0.0902710576396197	6.23522872697956	0.224606838434196	0.604791982414275	1:88684221-88836255:+	PKN2	43;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0010631,biological_process epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030496,cellular_component midbody;GO:0032154,cellular_component cleavage furrow;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035556,biological_process intracellular signal transduction;GO:0042826,molecular_function histone deacetylase binding;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0043296,cellular_component apical junction complex;GO:0043297,biological_process apical junction assembly;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045296,molecular_function cadherin binding;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0070063,molecular_function RNA polymerase binding;GO:2000145,biological_process regulation of cell motility	PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]; K06071	protein kinase N2 [Source:HGNC Symbol%3BAcc:HGNC:9406]
ENSG00000125755	30.54	30.47	28.92	31.96	31.64	31.90	-0.0752639962387651	7.00195045791312	0.224715712004585	0.604791982414275	19:45815409-45863290:-	SYMPK	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0031124,biological_process mRNA 3'-end processing;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0097165,cellular_component nuclear stress granule	SYMPK; symplekin; K06100	symplekin [Source:HGNC Symbol%3BAcc:HGNC:22935]
ENSG00000068438	56.74	48.90	59.58	66.15	52.64	61.41	-0.110322059971147	5.8359369169285	0.224722084284107	0.604791982414275	X:48476020-48486364:+	FTSJ1	14;GO:0001510,biological_process RNA methylation;GO:0002128,biological_process tRNA nucleoside ribose methylation;GO:0002181,biological_process cytoplasmic translation;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008175,molecular_function tRNA methyltransferase activity;GO:0009020,molecular_function tRNA (guanosine-2'-O-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0052666,molecular_function tRNA (cytosine-2'-O-)-methyltransferase activity	NA	FtsJ RNA methyltransferase homolog 1 (E. coli) [Source:HGNC Symbol%3BAcc:HGNC:13254]
ENSG00000127663	11.93	12.42	11.68	10.08	11.72	12.13	0.0961422266637994	5.43576846632392	0.224765809868196	0.604791982414275	19:4969112-5153595:+	KDM4B	17;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation;GO:1900113,biological_process negative regulation of histone H3-K9 trimethylation	NA	lysine demethylase 4B [Source:HGNC Symbol%3BAcc:HGNC:29136]
ENSG00000170236	1.28	1.41	1.59	1.04	0.98	1.28	0.380169338506445	0.686103118936617	0.224809619686877	0.604791982414275	15:50500561-50546708:-	USP50	3;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016579,biological_process protein deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 50 [Source:HGNC Symbol%3BAcc:HGNC:20079]
ENSG00000186522	73.88	76.72	76.33	72.37	70.99	73.81	0.074524296175516	6.95459472550154	0.224855126588105	0.604791982414275	2:109542981-109614206:-	SEPT10	7;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0051301,biological_process cell division	NA	septin 10 [Source:HGNC Symbol%3BAcc:HGNC:14349]
ENSG00000103995	6.68	6.94	5.60	5.86	5.67	6.38	0.109319973801282	5.01055135183589	0.224886087323203	0.604791982414275	15:48712927-48811146:-	CEP152	18;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000242,cellular_component pericentriolar material;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007099,biological_process centriole replication;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0019901,molecular_function protein kinase binding;GO:0030030,biological_process cell projection organization;GO:0051298,biological_process centrosome duplication;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0098535,biological_process de novo centriole assembly;GO:0098536,cellular_component deuterosome	NA	centrosomal protein 152 [Source:HGNC Symbol%3BAcc:HGNC:29298]
ENSG00000116560	117.15	128.18	111.64	119.93	139.29	124.22	-0.0920809500271036	8.04750770663877	0.224902907502158	0.604791982414275	1:35176377-35193148:-	SFPQ	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008380,biological_process RNA splicing;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0031012,cellular_component extracellular matrix;GO:0042382,cellular_component paraspeckles;GO:0042752,biological_process regulation of circadian rhythm;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045876,biological_process positive regulation of sister chromatid cohesion;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process;GO:0051276,biological_process chromosome organization;GO:0051726,biological_process regulation of cell cycle;GO:0070932,biological_process histone H3 deacetylation;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1902177,biological_process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	NA	splicing factor proline and glutamine rich [Source:HGNC Symbol%3BAcc:HGNC:10774]
ENSG00000107625	19.90	19.24	21.60	19.40	18.14	20.03	0.0909884194095213	5.50951392125352	0.225192304979919	0.60522204676112	10:68901277-68946847:+	DDX50	13;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity	NA	DExD-box helicase 50 [Source:HGNC Symbol%3BAcc:HGNC:17906]
ENSG00000011451	12.32	12.89	12.16	11.54	11.86	12.11	0.0825863355035595	5.38668789644011	0.22519793408068	0.60522204676112	19:15419979-15449951:-	WIZ	11;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0010571,biological_process positive regulation of nuclear cell cycle DNA replication;GO:0030496,cellular_component midbody;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome;GO:0070208,biological_process protein heterotrimerization;GO:0070984,molecular_function SET domain binding	NA	widely interspaced zinc finger motifs [Source:HGNC Symbol%3BAcc:HGNC:30917]
ENSG00000163444	38.88	43.29	40.26	38.90	40.75	35.91	0.0925607430529843	5.48688079168686	0.225209106097608	0.60522204676112	1:203007385-203024848:+	TMEM183A	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 183A [Source:HGNC Symbol%3BAcc:HGNC:20173]
ENSG00000107485	2.07	1.51	1.93	1.41	1.25	1.85	0.312745961811803	1.25857015560733	0.225384703463296	0.605464664825578	10:8053603-8075198:+	GATA3	152;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000902,biological_process cell morphogenesis;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001071,molecular_function nucleic acid binding transcription factor activity;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0001709,biological_process cell fate determination;GO:0001764,biological_process neuron migration;GO:0001775,biological_process cell activation;GO:0001806,biological_process type IV hypersensitivity;GO:0001819,biological_process positive regulation of cytokine production;GO:0001822,biological_process kidney development;GO:0001823,biological_process mesonephros development;GO:0002088,biological_process lens development in camera-type eye;GO:0002376,biological_process immune system process;GO:0002572,biological_process pro-T cell differentiation;GO:0003180,biological_process aortic valve morphogenesis;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0003281,biological_process ventricular septum development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005134,molecular_function interleukin-2 receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006952,biological_process defense response;GO:0006959,biological_process humoral immune response;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0009615,biological_process response to virus;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009791,biological_process post-embryonic development;GO:0009967,biological_process positive regulation of signal transduction;GO:0010332,biological_process response to gamma radiation;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010975,biological_process regulation of neuron projection development;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016579,biological_process protein deubiquitination;GO:0030182,biological_process neuron differentiation;GO:0030217,biological_process T cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0031929,biological_process TOR signaling;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0032736,biological_process positive regulation of interleukin-13 production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0032754,biological_process positive regulation of interleukin-5 production;GO:0033077,biological_process T cell differentiation in thymus;GO:0033600,biological_process negative regulation of mammary gland epithelial cell proliferation;GO:0035162,biological_process embryonic hemopoiesis;GO:0035457,biological_process cellular response to interferon-alpha;GO:0035799,biological_process ureter maturation;GO:0035898,biological_process parathyroid hormone secretion;GO:0042035,biological_process regulation of cytokine biosynthetic process;GO:0042421,biological_process norepinephrine biosynthetic process;GO:0042472,biological_process inner ear morphogenesis;GO:0042493,biological_process response to drug;GO:0043370,biological_process regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043583,biological_process ear development;GO:0043627,biological_process response to estrogen;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045061,biological_process thymic T cell selection;GO:0045064,biological_process T-helper 2 cell differentiation;GO:0045087,biological_process innate immune response;GO:0045471,biological_process response to ethanol;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0048469,biological_process cell maturation;GO:0048485,biological_process sympathetic nervous system development;GO:0048538,biological_process thymus development;GO:0048568,biological_process embryonic organ development;GO:0048589,biological_process developmental growth;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048872,biological_process homeostasis of number of cells;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051569,biological_process regulation of histone H3-K4 methylation;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060017,biological_process parathyroid gland development;GO:0060037,biological_process pharyngeal system development;GO:0060065,biological_process uterus development;GO:0060231,biological_process mesenchymal to epithelial transition;GO:0060374,biological_process mast cell differentiation;GO:0060676,biological_process ureteric bud formation;GO:0061085,biological_process regulation of histone H3-K27 methylation;GO:0061290,biological_process canonical Wnt signaling pathway involved in metanephric kidney development;GO:0070888,molecular_function E-box binding;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071353,biological_process cellular response to interleukin-4;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071442,biological_process positive regulation of histone H3-K14 acetylation;GO:0071599,biological_process otic vesicle development;GO:0071773,biological_process cellular response to BMP stimulus;GO:0071837,molecular_function HMG box domain binding;GO:0072001,biological_process renal system development;GO:0072107,biological_process positive regulation of ureteric bud formation;GO:0072178,biological_process nephric duct morphogenesis;GO:0072179,biological_process nephric duct formation;GO:0072182,biological_process regulation of nephron tubule epithelial cell differentiation;GO:0072602,biological_process interleukin-4 secretion;GO:0072643,biological_process interferon-gamma secretion;GO:0072676,biological_process lymphocyte migration;GO:0090102,biological_process cochlea development;GO:1901536,biological_process negative regulation of DNA demethylation;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000146,biological_process negative regulation of cell motility;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2000553,biological_process positive regulation of T-helper 2 cell cytokine production;GO:2000607,biological_process negative regulation of cell proliferation involved in mesonephros development;GO:2000611,biological_process positive regulation of thyroid hormone generation;GO:2000617,biological_process positive regulation of histone H3-K9 acetylation;GO:2000664,biological_process positive regulation of interleukin-5 secretion;GO:2000667,biological_process positive regulation of interleukin-13 secretion;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding;GO:2000683,biological_process regulation of cellular response to X-ray;GO:2000703,biological_process negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation;GO:2000734,biological_process negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	NA	GATA binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:4172]
ENSG00000119912	9.45	10.37	9.80	8.50	10.27	8.93	0.106454148056306	4.93845654473315	0.225396939995085	0.605464664825578	10:92451683-92574076:-	IDE	52;GO:0000166,molecular_function nucleotide binding;GO:0001540,molecular_function beta-amyloid binding;GO:0001618,molecular_function virus receptor activity;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008152,biological_process metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008340,biological_process determination of adult lifespan;GO:0009986,cellular_component cell surface;GO:0010815,biological_process bradykinin catabolic process;GO:0010992,biological_process ubiquitin homeostasis;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017046,molecular_function peptide hormone binding;GO:0031597,cellular_component cytosolic proteasome complex;GO:0031626,molecular_function beta-endorphin binding;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0042277,molecular_function peptide binding;GO:0042447,biological_process hormone catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043559,molecular_function insulin binding;GO:0044257,biological_process cellular protein catabolic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045861,biological_process negative regulation of proteolysis;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0050435,biological_process beta-amyloid metabolic process;GO:0051260,biological_process protein homooligomerization;GO:0051289,biological_process protein homotetramerization;GO:0051291,biological_process protein heterooligomerization;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0140036,Molecular_Function ubiquitin-dependent protein binding;GO:1901142,biological_process insulin metabolic process;GO:1901143,biological_process insulin catabolic process	IDE, ide; insulysin [EC:3.4.24.56]; K01408	insulin degrading enzyme [Source:HGNC Symbol%3BAcc:HGNC:5381]
ENSG00000187607	0.38	0.51	0.47	1.04	0.33	0.57	-0.500929092849446	0.236416665213555	0.225446142788707	0.605465809267896	17:15699576-15720787:+	ZNF286A	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 286A [Source:HGNC Symbol%3BAcc:HGNC:13501]
ENSG00000119938	11.73	12.56	12.54	12.36	11.48	9.46	0.156985317062225	3.49063245369787	0.225553941378573	0.605624286033362	10:91628441-91633054:-	PPP1R3C	10;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0006470,biological_process protein dephosphorylation;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0019903,molecular_function protein phosphatase binding;GO:0050790,biological_process regulation of catalytic activity	PPP1R3; protein phosphatase 1 regulatory subunit 3A/B/C/D/E; K07189	protein phosphatase 1 regulatory subunit 3C [Source:HGNC Symbol%3BAcc:HGNC:9293]
ENSG00000160712	2.17	2.82	2.73	2.21	2.23	2.16	0.225625284750553	1.946605897899	0.225631654895202	0.605701931707212	1:154405192-154469450:+	IL6R	36;GO:0002384,biological_process hepatic immune response;GO:0002548,biological_process monocyte chemotaxis;GO:0002690,biological_process positive regulation of leukocyte chemotaxis;GO:0004896,molecular_function cytokine receptor activity;GO:0004897,molecular_function ciliary neurotrophic factor receptor activity;GO:0004915,molecular_function interleukin-6 receptor activity;GO:0005138,molecular_function interleukin-6 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005896,cellular_component interleukin-6 receptor complex;GO:0006953,biological_process acute-phase response;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019899,molecular_function enzyme binding;GO:0019981,molecular_function interleukin-6 binding;GO:0031018,biological_process endocrine pancreas development;GO:0032722,biological_process positive regulation of chemokine production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0034097,biological_process response to cytokine;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042803,molecular_function protein homodimerization activity;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0070102,biological_process interleukin-6-mediated signaling pathway;GO:0070110,cellular_component ciliary neurotrophic factor receptor complex;GO:0070119,molecular_function ciliary neurotrophic factor binding;GO:0070120,biological_process ciliary neurotrophic factor-mediated signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway	IL6R, CD126; interleukin 6 receptor; K05055	interleukin 6 receptor [Source:HGNC Symbol%3BAcc:HGNC:6019]
ENSG00000160753	9.55	9.45	7.92	7.69	8.62	8.69	0.11532146285681	4.62307232886527	0.225700590767876	0.605738356581753	1:155320895-155331114:+	RUSC1	21;GO:0000209,biological_process protein polyubiquitination;GO:0003779,molecular_function actin binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0009967,biological_process positive regulation of signal transduction;GO:0014069,cellular_component postsynaptic density;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	RUN and SH3 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17153]
ENSG00000165714	5.64	5.19	5.25	5.47	5.79	8.24	-0.268152974263358	1.87569051823447	0.225742821038201	0.605738356581753	12:12357078-12469694:+	BORCS5	10;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005873,cellular_component plus-end kinesin complex;GO:0016020,cellular_component membrane;GO:0031224,cellular_component intrinsic component of membrane;GO:0032418,biological_process lysosome localization;GO:0072384,biological_process organelle transport along microtubule;GO:0098574,cellular_component cytoplasmic side of lysosomal membrane;GO:0099078,cellular_component BORC complex	NA	BLOC-1 related complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:17950]
ENSG00000056972	15.18	13.65	15.60	16.52	15.28	16.37	-0.0998316749889994	4.74457841267822	0.225898172833599	0.606024209938073	6:111556453-111606278:-	TRAF3IP2	11;GO:0001783,biological_process B cell apoptotic process;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0006959,biological_process humoral immune response;GO:0007165,biological_process signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048305,biological_process immunoglobulin secretion	NA	TRAF3 interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1343]
ENSG00000114841	1.02	0.81	1.02	0.91	0.84	0.86	0.151394722185392	3.56725575841435	0.226012908984321	0.606129498846869	3:52316318-52400491:+	DNAH1	25;GO:0000166,molecular_function nucleotide binding;GO:0003341,biological_process cilium movement;GO:0003351,biological_process epithelial cilium movement;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005858,cellular_component axonemal dynein complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0016887,molecular_function ATPase activity;GO:0030286,cellular_component dynein complex;GO:0030317,biological_process sperm motility;GO:0036126,cellular_component sperm flagellum;GO:0036156,cellular_component inner dynein arm;GO:0036159,biological_process inner dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060285,biological_process cilium-dependent cell motility;GO:0060294,biological_process cilium movement involved in cell motility	DNAH; dynein heavy chain, axonemal; K10408	dynein axonemal heavy chain 1 [Source:HGNC Symbol%3BAcc:HGNC:2940]
ENSG00000115539	24.05	28.95	23.58	27.30	32.63	25.17	-0.146472460468009	4.33647374735492	0.226076350751369	0.606129498846869	2:100562689-100576735:+	PDCL3	16;GO:0001525,biological_process angiogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006915,biological_process apoptotic process;GO:0008479,molecular_function queuine tRNA-ribosyltransferase activity;GO:0008616,biological_process queuosine biosynthetic process;GO:0016032,biological_process viral process;GO:0043184,molecular_function vascular endothelial growth factor receptor 2 binding;GO:0044183,molecular_function protein binding involved in protein folding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	phosducin like 3 [Source:HGNC Symbol%3BAcc:HGNC:28860]
ENSG00000134545	1.72	0.82	1.05	1.39	1.63	2.11	-0.465818825440471	0.250654285555382	0.226083910389189	0.606129498846869	12:10442263-10454685:-	KLRC1	11;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0023024,molecular_function MHC class I protein complex binding;GO:0030246,molecular_function carbohydrate binding;GO:0043235,cellular_component receptor complex;GO:0050776,biological_process regulation of immune response	KLRC, CD159; killer cell lectin-like receptor subfamily C; K06541	killer cell lectin like receptor C1 [Source:HGNC Symbol%3BAcc:HGNC:6374]
ENSG00000163320	72.04	67.14	71.10	73.38	61.16	63.02	0.104485025657622	5.09751998429289	0.226184303671989	0.606267709237831	3:88051943-88149885:-	CGGBP1	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0042802,molecular_function identical protein binding	NA	CGG triplet repeat binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1888]
ENSG00000164086	5.31	3.81	4.76	4.33	3.70	4.17	0.210819527175581	2.57824985657966	0.226335277948463	0.606385499433722	3:52048918-52056550:-	DUSP7	17;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0000188,biological_process inactivation of MAPK activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043407,biological_process negative regulation of MAP kinase activity	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 7 [Source:HGNC Symbol%3BAcc:HGNC:3073]
ENSG00000110717	66.51	62.50	57.59	56.53	60.06	60.28	0.0888928837930698	5.67580308141835	0.226355907891138	0.606385499433722	11:68030616-68036644:+	NDUFS8	16;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005759,cellular_component mitochondrial matrix;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006979,biological_process response to oxidative stress;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2 1.6.99.3]; K03941	NADH:ubiquinone oxidoreductase core subunit S8 [Source:HGNC Symbol%3BAcc:HGNC:7715]
ENSG00000187626	6.18	6.08	6.12	6.00	7.28	7.23	-0.146412275322714	3.42921397416034	0.226417133539586	0.606385499433722	6:28244622-28252224:-	ZKSCAN4	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger with KRAB and SCAN domains 4 [Source:HGNC Symbol%3BAcc:HGNC:13854]
ENSG00000185973	7.29	8.76	9.38	9.49	8.64	10.33	-0.155905894351539	3.66701111217846	0.226423651806598	0.606385499433722	X:155490114-155669944:-	TMLHE	10;GO:0005506,molecular_function iron ion binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0045329,biological_process carnitine biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0050353,molecular_function trimethyllysine dioxygenase activity;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	TMLHE; trimethyllysine dioxygenase [EC:1.14.11.8]; K00474	trimethyllysine hydroxylase%2C epsilon [Source:HGNC Symbol%3BAcc:HGNC:18308]
ENSG00000109787	20.93	23.15	24.30	23.42	24.89	25.93	-0.109529467629174	4.63205790895501	0.226532199590048	0.606439145477353	4:38664195-38701042:+	KLF3	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding;GO:1901653,biological_process cellular response to peptide	KLF3; krueppel-like factor 3; K15605	Kruppel like factor 3 [Source:HGNC Symbol%3BAcc:HGNC:16516]
ENSG00000071655	51.06	53.66	49.53	47.26	49.14	50.25	0.0814555078927346	5.59334718448623	0.226607658783577	0.606439145477353	19:1573595-1592801:-	MBD3	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000792,cellular_component heterochromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006346,biological_process methylation-dependent chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007568,biological_process aging;GO:0008327,molecular_function methyl-CpG binding;GO:0009888,biological_process tissue development;GO:0014070,biological_process response to organic cyclic compound;GO:0016573,biological_process histone acetylation;GO:0016575,biological_process histone deacetylation;GO:0016581,cellular_component NuRD complex;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031667,biological_process response to nutrient levels;GO:0032355,biological_process response to estradiol;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0044030,biological_process regulation of DNA methylation;GO:0048568,biological_process embryonic organ development;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	methyl-CpG binding domain protein 3 [Source:HGNC Symbol%3BAcc:HGNC:6918]
ENSG00000115756	129.05	115.33	126.56	122.59	108.61	121.01	0.0883309847274696	6.4153598086088	0.226629249476839	0.606439145477353	2:10302888-10427617:+	HPCAL1	5;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	hippocalcin like 1 [Source:HGNC Symbol%3BAcc:HGNC:5145]
ENSG00000138442	31.83	34.27	32.07	33.45	35.62	35.91	-0.0885456992519558	5.43053974048623	0.226639103832227	0.606439145477353	2:202874781-203014798:-	WDR12	14;GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466,biological_process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0007219,biological_process Notch signaling pathway;GO:0008283,biological_process cell proliferation;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0070545,cellular_component PeBoW complex	NA	WD repeat domain 12 [Source:HGNC Symbol%3BAcc:HGNC:14098]
ENSG00000176383	8.22	9.61	7.01	6.14	6.35	9.05	0.205060028439438	3.15033654318445	0.22681591744585	0.606781461908477	12:122203542-122208952:+	B3GNT4	13;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0008499,molecular_function UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0008532,molecular_function N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0030311,biological_process poly-N-acetyllactosamine biosynthetic process	B3GNT4; beta-1,3-N-acetylglucosaminyltransferase 4 [EC:2.4.1.149]; K07971	UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:15683]
ENSG00000197756	1637.02	1374.89	1424.07	1653.28	1439.63	1692.41	-0.0974356581840629	9.40911227811118	0.226932967998965	0.606963786203654	2:216498188-216579180:+	RPL37A	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein L37a [Source:HGNC Symbol%3BAcc:HGNC:10348]
ENSG00000149658	26.41	24.62	25.67	23.39	23.88	25.62	0.0869202011966287	5.39266209593486	0.227098251585693	0.607151465070719	20:63195428-63216234:-	YTHDF1	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0043022,molecular_function ribosome binding;GO:0045727,biological_process positive regulation of translation;GO:0045948,biological_process positive regulation of translational initiation;GO:1990247,molecular_function N6-methyladenosine-containing RNA binding	NA	YTH N6-methyladenosine RNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15867]
ENSG00000182718	1282.59	1325.22	1249.25	1242.69	1248.30	1215.25	0.0692376952880565	10.6481738871273	0.227100962887565	0.607151465070719	15:60347133-60402883:-	ANXA2	77;GO:0001525,biological_process angiogenesis;GO:0001726,cellular_component ruffle;GO:0001765,biological_process membrane raft assembly;GO:0001921,biological_process positive regulation of receptor recycling;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002020,molecular_function protease binding;GO:0003723,molecular_function RNA binding;GO:0004859,molecular_function phospholipase inhibitor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005938,cellular_component cell cortex;GO:0006900,biological_process membrane budding;GO:0007589,biological_process body fluid secretion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0019834,molecular_function phospholipase A2 inhibitor activity;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0030199,biological_process collagen fibril organization;GO:0030496,cellular_component midbody;GO:0030546,molecular_function receptor activator activity;GO:0031012,cellular_component extracellular matrix;GO:0031340,biological_process positive regulation of vesicle fusion;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0032804,biological_process negative regulation of low-density lipoprotein particle receptor catabolic process;GO:0035578,cellular_component azurophil granule lumen;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0035749,cellular_component myelin sheath adaxonal region;GO:0036035,biological_process osteoclast development;GO:0042383,cellular_component sarcolemma;GO:0042470,cellular_component melanosome;GO:0042730,biological_process fibrinolysis;GO:0042802,molecular_function identical protein binding;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043220,cellular_component Schmidt-Lanterman incisure;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0044090,biological_process positive regulation of vacuole organization;GO:0044147,biological_process negative regulation of development of symbiont involved in interaction with host;GO:0044354,cellular_component macropinosome;GO:0044548,molecular_function S100 protein binding;GO:0045121,cellular_component membrane raft;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051099,biological_process positive regulation of binding;GO:0051290,biological_process protein heterotetramerization;GO:0052362,biological_process catabolism by host of symbiont protein;GO:0052405,biological_process negative regulation by host of symbiont molecular function;GO:0070062,cellular_component extracellular exosome;GO:0072661,biological_process protein targeting to plasma membrane;GO:0097066,biological_process response to thyroid hormone;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:1905581,biological_process positive regulation of low-density lipoprotein particle clearance;GO:1905597,biological_process positive regulation of low-density lipoprotein particle receptor binding;GO:1905599,biological_process positive regulation of low-density lipoprotein receptor activity;GO:1905602,biological_process positive regulation of receptor-mediated endocytosis involved in cholesterol transport;GO:1990667,cellular_component PCSK9-AnxA2 complex	NA	annexin A2 [Source:HGNC Symbol%3BAcc:HGNC:537]
ENSG00000180257	6.94	7.52	6.33	6.27	6.66	6.21	0.125119423036572	3.88113914407517	0.227261634692279	0.607450187647559	19:52949378-52962911:-	ZNF816	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 816 [Source:HGNC Symbol%3BAcc:HGNC:26995]
ENSG00000130958	20.38	19.08	21.67	18.87	17.76	20.36	0.116079834940085	4.3298869228385	0.227524045189955	0.608020661559292	9:96320705-96383710:-	SLC35D2	15;GO:0000139,cellular_component Golgi membrane;GO:0005338,molecular_function nucleotide-sugar transmembrane transporter activity;GO:0005575,cellular_component cellular_component;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0008643,biological_process carbohydrate transport;GO:0015165,molecular_function pyrimidine nucleotide-sugar transmembrane transporter activity;GO:0015931,biological_process nucleobase-containing compound transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0090481,biological_process pyrimidine nucleotide-sugar transmembrane transport;GO:1901264,biological_process carbohydrate derivative transport	NA	solute carrier family 35 member D2 [Source:HGNC Symbol%3BAcc:HGNC:20799]
ENSG00000164068	14.48	14.32	14.87	13.11	14.58	13.95	0.081671983929306	5.84979506620093	0.227753677254981	0.608194208972717	3:49689498-49721529:+	RNF123	6;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 123 [Source:HGNC Symbol%3BAcc:HGNC:21148]
ENSG00000198830	1045.26	1131.92	1013.51	1120.03	1226.12	1068.84	-0.0868167080898222	8.21692982717687	0.227765347189809	0.608194208972717	1:26472449-26475972:+	HMGN2	10;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031640,biological_process killing of cells of other organism;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide	NA	high mobility group nucleosomal binding domain 2 [Source:HGNC Symbol%3BAcc:HGNC:4986]
ENSG00000263002	3.07	3.07	3.02	2.58	2.58	2.99	0.177163436678608	2.64583803961177	0.227805300682987	0.608194208972717	19:44141556-44160309:+	ZNF234	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 234 [Source:HGNC Symbol%3BAcc:HGNC:13027]
ENSG00000093144	72.45	82.48	72.69	71.54	71.46	73.13	0.0832213585191882	6.3805106568229	0.227809860276751	0.608194208972717	6:127288709-127343609:-	ECHDC1	13;GO:0003824,molecular_function catalytic activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0004492,molecular_function methylmalonyl-CoA decarboxylase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0070062,cellular_component extracellular exosome	NA	ethylmalonyl-CoA decarboxylase 1 [Source:HGNC Symbol%3BAcc:HGNC:21489]
ENSG00000169567	422.64	402.62	391.72	447.52	414.46	431.07	-0.0756322648890525	7.8944320927784	0.227896144409802	0.608194208972717	5:131159026-131171735:-	HINT1	18;GO:0000118,cellular_component histone deacetylase complex;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005080,molecular_function protein kinase C binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0009154,biological_process purine ribonucleotide catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0050850,biological_process positive regulation of calcium-mediated signaling;GO:0070062,cellular_component extracellular exosome;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	NA	histidine triad nucleotide binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4912]
ENSG00000130312	27.25	24.93	23.33	21.97	20.20	26.50	0.147448611188785	3.74770249649679	0.227898262406742	0.608194208972717	19:17292608-17306843:+	MRPL34	11;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34; K02914	mitochondrial ribosomal protein L34 [Source:HGNC Symbol%3BAcc:HGNC:14488]
ENSG00000143977	187.99	171.91	166.73	182.49	191.49	188.40	-0.0815738984760948	5.96534159975456	0.227931963275685	0.608194208972717	2:70281361-70293771:-	SNRPG	30;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005683,cellular_component U7 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0034709,cellular_component methylosome;GO:0034719,cellular_component SMN-Sm protein complex;GO:0043186,cellular_component P granule;GO:0051170,biological_process nuclear import;GO:0071004,cellular_component U2-type prespliceosome;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097526,cellular_component spliceosomal tri-snRNP complex	NA	small nuclear ribonucleoprotein polypeptide G [Source:HGNC Symbol%3BAcc:HGNC:11163]
ENSG00000131873	14.62	14.66	15.51	13.60	14.69	14.17	0.0895870715509787	5.13560721762432	0.227999128191889	0.608242677465273	15:101175722-101251932:-	CHSY1	21;GO:0000139,cellular_component Golgi membrane;GO:0002063,biological_process chondrocyte development;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0009954,biological_process proximal/distal pattern formation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030279,biological_process negative regulation of ossification;GO:0031667,biological_process response to nutrient levels;GO:0032580,cellular_component Golgi cisterna membrane;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0047238,molecular_function glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0050510,molecular_function N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity;GO:0051216,biological_process cartilage development;GO:0051923,biological_process sulfation;GO:0060349,biological_process bone morphogenesis	CHSY; chondroitin sulfate synthase [EC:2.4.1.175 2.4.1.226]; K13499	chondroitin sulfate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:17198]
ENSG00000183431	57.89	56.97	63.17	64.66	60.20	65.41	-0.0831791647699653	6.53168857596072	0.228150385374268	0.608493372498551	1:37956974-37990921:-	SF3A3	15;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000389,biological_process mRNA 3'-splice site recognition;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding;GO:0071013,cellular_component catalytic step 2 spliceosome	SF3A3, SAP61, PRP9; splicing factor 3A subunit 3; K12827	splicing factor 3a subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:10767]
ENSG00000081665	5.46	4.33	5.82	6.48	5.56	5.72	-0.160924550079452	3.31087039834255	0.228228571005858	0.608493372498551	19:19785838-19821751:-	ZNF506	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 506 [Source:HGNC Symbol%3BAcc:HGNC:23780]
ENSG00000197961	10.30	8.96	9.60	10.47	10.02	11.57	-0.13499141132994	3.59857715126693	0.228240162922199	0.608493372498551	19:9560352-9584533:-	ZNF121	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 121 [Source:HGNC Symbol%3BAcc:HGNC:12904]
ENSG00000198108	0.32	0.47	0.17	0.57	0.40	0.37	-0.513316736123072	0.205621133204191	0.228537717969086	0.609047640797343	5:129904471-130186634:+	CHSY3	11;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0047238,molecular_function glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0050510,molecular_function N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHSY; chondroitin sulfate synthase [EC:2.4.1.175 2.4.1.226]; K13499	chondroitin sulfate synthase 3 [Source:HGNC Symbol%3BAcc:HGNC:24293]
ENSG00000253251	1.22	0.76	1.86	0.90	2.33	2.16	-0.434827482482668	0.410318398003251	0.22854978059081	0.609047640797343	5:65624764-65630891:+	AC008560.1	NA	NA	Uncharacterized protein FLJ26957  [Source:UniProtKB/Swiss-Prot%3BAcc:Q6ZNX1]
ENSG00000074527	8.70	8.72	9.06	8.58	7.37	8.58	0.121250505656524	4.01600295346872	0.228595259685396	0.609047640797343	12:95657806-95791152:-	NTN4	9;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005886,cellular_component plasma membrane;GO:0007411,biological_process axon guidance;GO:0016322,biological_process neuron remodeling;GO:0043237,molecular_function laminin-1 binding;GO:0060668,biological_process regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling	NTN4; netrin 4; K06845	netrin 4 [Source:HGNC Symbol%3BAcc:HGNC:13658]
ENSG00000177732	17.19	15.67	15.11	15.69	17.42	20.09	-0.137025932501189	4.01213472036736	0.228661309241533	0.609092882320848	20:325594-330224:+	SOX12	16;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0021510,biological_process spinal cord development;GO:0032993,cellular_component protein-DNA complex;GO:0045165,biological_process cell fate commitment;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0065004,biological_process protein-DNA complex assembly	NA	SRY-box 12 [Source:HGNC Symbol%3BAcc:HGNC:11198]
ENSG00000188707	17.16	23.35	16.22	18.82	25.28	20.46	-0.185530241611277	3.84725526993363	0.228763169582314	0.609233474367144	7:150329788-150332721:+	ZBED6CL	NA	NA	ZBED6 C-terminal like [Source:HGNC Symbol%3BAcc:HGNC:21720]
ENSG00000109790	27.10	23.60	27.91	24.15	22.75	27.19	0.100019052475082	5.95912887611717	0.228912463156083	0.609494113896784	4:39045038-39126857:+	KLHL5	10;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification	NA	kelch like family member 5 [Source:HGNC Symbol%3BAcc:HGNC:6356]
ENSG00000111229	360.93	408.39	360.42	350.80	377.37	344.61	0.0853254315819386	7.61626282057017	0.229005767974392	0.609494113896784	12:110434824-110450422:-	ARPC3	24;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0030833,biological_process regulation of actin filament polymerization;GO:0031252,cellular_component cell leading edge;GO:0031941,cellular_component filamentous actin;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0061024,biological_process membrane organization;GO:0061850,cellular_component growth cone leading edge;GO:0070062,cellular_component extracellular exosome;GO:1990090,biological_process cellular response to nerve growth factor stimulus	ARPC3; actin related protein 2/3 complex, subunit 3; K05756	actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:706]
ENSG00000205302	54.00	49.90	53.96	54.51	54.29	59.76	-0.0813548101448924	6.41088068718088	0.229010877304384	0.609494113896784	5:122774995-122830108:+	SNX2	34;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0019898,cellular_component extrinsic component of membrane;GO:0030027,cellular_component lamellipodium;GO:0030904,cellular_component retromer complex;GO:0030905,cellular_component retromer, tubulation complex;GO:0031901,cellular_component early endosome membrane;GO:0034498,biological_process early endosome to Golgi transport;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0045296,molecular_function cadherin binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome;GO:0072673,biological_process lamellipodium morphogenesis;GO:1990459,molecular_function transferrin receptor binding;GO:1990460,molecular_function leptin receptor binding	NA	sorting nexin 2 [Source:HGNC Symbol%3BAcc:HGNC:11173]
ENSG00000198838	0.30	0.27	0.37	0.35	0.37	0.39	-0.205100370073118	2.399442537516	0.229057443110328	0.609494113896784	15:33310944-33866121:+	RYR3	32;GO:0005216,molecular_function ion channel activity;GO:0005219,molecular_function ryanodine-sensitive calcium-release channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005516,molecular_function calmodulin binding;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0031090,cellular_component organelle membrane;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034220,biological_process ion transmembrane transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048763,molecular_function calcium-induced calcium release activity;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051289,biological_process protein homotetramerization;GO:0051481,biological_process negative regulation of cytosolic calcium ion concentration;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071277,biological_process cellular response to calcium ion;GO:0071286,biological_process cellular response to magnesium ion;GO:0071313,biological_process cellular response to caffeine;GO:0071318,biological_process cellular response to ATP;GO:1903779,biological_process regulation of cardiac conduction	RYR3; ryanodine receptor 3; K04963	ryanodine receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:10485]
ENSG00000204138	25.23	27.87	27.36	27.70	29.78	28.35	-0.083548164105388	5.98976270453185	0.22921350320321	0.609663314958282	1:28369581-28500369:+	PHACTR4	22;GO:0001755,biological_process neural crest cell migration;GO:0001843,biological_process neural tube closure;GO:0003779,molecular_function actin binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0007266,biological_process Rho protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0042995,cellular_component cell projection;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0048484,biological_process enteric nervous system development;GO:0050790,biological_process regulation of catalytic activity;GO:0051726,biological_process regulation of cell cycle;GO:0061386,biological_process closure of optic fissure;GO:0072542,molecular_function protein phosphatase activator activity;GO:2001045,biological_process negative regulation of integrin-mediated signaling pathway	NA	phosphatase and actin regulator 4 [Source:HGNC Symbol%3BAcc:HGNC:25793]
ENSG00000111859	16.89	17.22	18.87	20.37	17.38	19.29	-0.094570932301223	5.65219396332546	0.229295537485141	0.609663314958282	6:11183297-11382348:-	NEDD9	23;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0040008,biological_process regulation of growth;GO:0042995,cellular_component cell projection;GO:0051017,biological_process actin filament bundle assembly;GO:0051301,biological_process cell division	NA	neural precursor cell expressed%2C developmentally down-regulated 9 [Source:HGNC Symbol%3BAcc:HGNC:7733]
ENSG00000010810	8.95	7.63	12.04	8.86	6.61	9.71	0.201151434199615	4.00735100453491	0.229317220141318	0.609663314958282	6:111660331-111873452:-	FYN	109;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001764,biological_process neuron migration;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006816,biological_process calcium ion transport;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0007596,biological_process blood coagulation;GO:0007612,biological_process learning;GO:0007631,biological_process feeding behavior;GO:0008360,biological_process regulation of cell shape;GO:0010629,biological_process negative regulation of gene expression;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014069,cellular_component postsynaptic density;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0030425,cellular_component dendrite;GO:0030900,biological_process forebrain development;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031295,biological_process T cell costimulation;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031802,molecular_function type 5 metabotropic glutamate receptor binding;GO:0032403,molecular_function protein complex binding;GO:0035556,biological_process intracellular signal transduction;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042110,biological_process T cell activation;GO:0042127,biological_process regulation of cell proliferation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042493,biological_process response to drug;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042608,molecular_function T cell receptor binding;GO:0042609,molecular_function CD4 receptor binding;GO:0042610,molecular_function CD8 receptor binding;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0044325,molecular_function ion channel binding;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045471,biological_process response to ethanol;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0046875,molecular_function ephrin receptor binding;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048813,biological_process dendrite morphogenesis;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050798,biological_process activated T cell proliferation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0050966,biological_process detection of mechanical stimulus involved in sensory perception of pain;GO:0051428,molecular_function peptide hormone receptor binding;GO:0070851,molecular_function growth factor receptor binding;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071944,cellular_component cell periphery;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0097718,molecular_function disordered domain specific binding;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901216,biological_process positive regulation of neuron death;GO:1902951,biological_process negative regulation of dendritic spine maintenance;GO:1904645,biological_process response to beta-amyloid;GO:1905664,biological_process regulation of calcium ion import across plasma membrane;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]; K05703	FYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:4037]
ENSG00000131779	25.71	23.56	22.24	28.30	23.68	26.40	-0.11956220338075	4.31859309058127	0.229317491141563	0.609663314958282	1:145911349-145918837:-	PEX11B	14;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0007031,biological_process peroxisome organization;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016559,biological_process peroxisome fission;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0044375,biological_process regulation of peroxisome size;GO:0051260,biological_process protein homooligomerization;GO:0070062,cellular_component extracellular exosome	PEX11B; peroxin-11B; K13352	peroxisomal biogenesis factor 11 beta [Source:HGNC Symbol%3BAcc:HGNC:8853]
ENSG00000100592	4.96	5.09	5.84	4.42	5.14	5.11	0.128558665332778	4.06258553134183	0.229391755627448	0.609730163298397	14:59188645-59371405:+	DAAM1	16;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0031514,cellular_component motile cilium;GO:0036064,cellular_component ciliary basal body;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway	DAAM; dishevelled associated activator of morphogenesis; K04512	dishevelled associated activator of morphogenesis 1 [Source:HGNC Symbol%3BAcc:HGNC:18142]
ENSG00000158856	38.23	36.57	38.03	36.92	34.91	35.71	0.0829275611358455	5.49524214606417	0.229453559150109	0.609763868492892	8:22048994-22082527:+	DMTN	51;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0012505,cellular_component endomembrane system;GO:0014069,cellular_component postsynaptic density;GO:0014731,cellular_component spectrin-associated cytoskeleton;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030194,biological_process positive regulation of blood coagulation;GO:0030507,molecular_function spectrin binding;GO:0030863,cellular_component cortical cytoskeleton;GO:0031095,cellular_component platelet dense tubular network membrane;GO:0031253,cellular_component cell projection membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0035585,biological_process calcium-mediated signaling using extracellular calcium source;GO:0042995,cellular_component cell projection;GO:0043621,molecular_function protein self-association;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048821,biological_process erythrocyte development;GO:0050732,biological_process negative regulation of peptidyl-tyrosine phosphorylation;GO:0051017,biological_process actin filament bundle assembly;GO:0051489,biological_process regulation of filopodium assembly;GO:0051693,biological_process actin filament capping;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0055085,biological_process transmembrane transport;GO:0070560,biological_process protein secretion by platelet;GO:0071277,biological_process cellular response to calcium ion;GO:0071320,biological_process cellular response to cAMP;GO:0090303,biological_process positive regulation of wound healing;GO:0090315,biological_process negative regulation of protein targeting to membrane;GO:0090527,biological_process actin filament reorganization;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1901731,biological_process positive regulation of platelet aggregation;GO:2001046,biological_process positive regulation of integrin-mediated signaling pathway	NA	dematin actin binding protein [Source:HGNC Symbol%3BAcc:HGNC:3382]
ENSG00000189042	5.87	6.59	6.53	6.11	5.30	5.92	0.137797785578026	3.59363728436979	0.22952684636096	0.609799730028137	19:36687611-36727701:+	ZNF567	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 567 [Source:HGNC Symbol%3BAcc:HGNC:28696]
ENSG00000124783	76.23	85.11	70.28	70.44	77.52	70.46	0.0935795777996574	6.22480398522497	0.2295653056007	0.609799730028137	6:7268305-7347446:-	SSR1	8;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response	SSR1; translocon-associated protein subunit alpha; K13249	signal sequence receptor subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:11323]
ENSG00000196436	2.60	3.67	3.05	2.82	2.28	2.75	0.237674623173595	1.97062002017818	0.2297537511426	0.61016972891166	16:74377877-74392080:+	NPIPB15	2;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex interacting protein family member B15 [Source:HGNC Symbol%3BAcc:HGNC:34409]
ENSG00000229809	5.08	3.05	4.63	3.00	3.94	3.91	0.265845239255916	2.17483190241028	0.229869257177416	0.610345901463799	16:30569345-30572734:-	ZNF688	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 688 [Source:HGNC Symbol%3BAcc:HGNC:30489]
ENSG00000143320	7.85	5.54	8.18	10.13	7.14	9.00	-0.252377559088251	1.80387538156523	0.229970074257657	0.610403698638013	1:156699605-156705816:-	CRABP2	22;GO:0001972,molecular_function retinoic acid binding;GO:0002138,biological_process retinoic acid biosynthetic process;GO:0005215,molecular_function transporter activity;GO:0005501,molecular_function retinoid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0008544,biological_process epidermis development;GO:0016918,molecular_function retinal binding;GO:0019841,molecular_function retinol binding;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0042573,biological_process retinoic acid metabolic process;GO:0048385,biological_process regulation of retinoic acid receptor signaling pathway;GO:0048672,biological_process positive regulation of collateral sprouting;GO:0070062,cellular_component extracellular exosome	NA	cellular retinoic acid binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:2339]
ENSG00000104863	3.12	2.58	3.41	3.55	4.17	3.34	-0.248966764225075	1.71867220127041	0.229989373924917	0.610403698638013	19:49114323-49118460:+	LIN7B	21;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0007269,biological_process neurotransmitter secretion;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0043005,cellular_component neuron projection;GO:0045199,biological_process maintenance of epithelial cell apical/basal polarity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0097016,molecular_function L27 domain binding;GO:0097025,cellular_component MPP7-DLG1-LIN7 complex;GO:0098793,cellular_component presynapse;GO:1903361,biological_process protein localization to basolateral plasma membrane	NA	lin-7 homolog B%2C crumbs cell polarity complex component [Source:HGNC Symbol%3BAcc:HGNC:17788]
ENSG00000101464	21.32	24.61	18.95	22.78	25.63	22.52	-0.123143512060093	4.88939505317023	0.23018835921033	0.610673526970147	20:34560541-34698790:-	PIGU	12;GO:0003923,molecular_function GPI-anchor transamidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016255,biological_process attachment of GPI anchor to protein;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034235,molecular_function GPI anchor binding;GO:0042765,cellular_component GPI-anchor transamidase complex;GO:0046425,biological_process regulation of JAK-STAT cascade	PIGU; GPI-anchor transamidase subunit U; K05293	phosphatidylinositol glycan anchor biosynthesis class U [Source:HGNC Symbol%3BAcc:HGNC:15791]
ENSG00000243943	17.27	14.83	15.23	13.20	14.94	16.00	0.115698555213874	4.70790249302694	0.23018943306963	0.610673526970147	2:27582968-27623215:+	ZNF512	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 512 [Source:HGNC Symbol%3BAcc:HGNC:29380]
ENSG00000185305	1.57	3.03	2.34	2.85	2.29	3.79	-0.391640661822991	0.857390220350045	0.23026958759063	0.610700306171659	5:53883944-54310582:-	ARL15	7;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome	NA	ADP ribosylation factor like GTPase 15 [Source:HGNC Symbol%3BAcc:HGNC:25945]
ENSG00000156345	9.97	8.70	9.70	7.99	8.03	9.66	0.159350003310944	3.30507842386889	0.230329701782082	0.610700306171659	9:87966440-87974753:-	CDK20	20;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019912,molecular_function cyclin-dependent protein kinase activating kinase activity;GO:0042995,cellular_component cell projection;GO:0051301,biological_process cell division;GO:1904031,biological_process positive regulation of cyclin-dependent protein kinase activity	NA	cyclin dependent kinase 20 [Source:HGNC Symbol%3BAcc:HGNC:21420]
ENSG00000131828	66.30	76.64	68.52	72.55	83.59	71.66	-0.0974025172796307	6.70078314711637	0.230347122653324	0.610700306171659	X:19343892-19361705:+	PDHA1	22;GO:0004738,molecular_function pyruvate dehydrogenase activity;GO:0004739,molecular_function pyruvate dehydrogenase (acetyl-transferring) activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006086,biological_process acetyl-CoA biosynthetic process from pyruvate;GO:0006090,biological_process pyruvate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0008152,biological_process metabolic process;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016491,molecular_function oxidoreductase activity;GO:0016624,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;GO:0034604,molecular_function pyruvate dehydrogenase (NAD+) activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0043209,cellular_component myelin sheath;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045254,cellular_component pyruvate dehydrogenase complex;GO:0055114,biological_process oxidation-reduction process;GO:0061732,biological_process mitochondrial acetyl-CoA biosynthetic process from pyruvate	PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]; K00161	pyruvate dehydrogenase alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:8806]
ENSG00000002587	2.53	3.63	1.36	1.14	2.96	1.30	0.471631081571785	1.05762056146212	0.230494331543169	0.610960097682118	4:11393149-11429765:-	HS3ST1	7;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0008146,molecular_function sulfotransferase activity;GO:0008467,molecular_function [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity	HS3ST1; [heparan sulfate]-glucosamine 3-sulfotransferase 1 [EC:2.8.2.23]; K01024	heparan sulfate-glucosamine 3-sulfotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:5194]
ENSG00000134574	13.50	12.54	14.74	17.66	14.13	13.54	-0.136116221273483	4.37672093555192	0.230579802531239	0.610982666318486	11:47214464-47239240:+	DDB2	31;GO:0000209,biological_process protein polyubiquitination;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006290,biological_process pyrimidine dimer repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0030054,cellular_component cell junction;GO:0031465,cellular_component Cul4B-RING E3 ubiquitin ligase complex;GO:0032403,molecular_function protein complex binding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0035518,biological_process histone H2A monoubiquitination;GO:0043234,cellular_component protein complex;GO:0043687,biological_process post-translational protein modification;GO:0051865,biological_process protein autoubiquitination;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070914,biological_process UV-damage excision repair;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	DDB2; DNA damage-binding protein 2; K10140	damage specific DNA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:2718]
ENSG00000169180	39.50	36.62	37.91	41.25	37.85	42.48	-0.0799869686130151	7.12492016989431	0.230667532469555	0.610982666318486	16:28097978-28211920:-	XPO6	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport	NA	exportin 6 [Source:HGNC Symbol%3BAcc:HGNC:19733]
ENSG00000089902	17.52	15.89	16.34	17.44	17.10	19.43	-0.103305094631736	4.66510534651589	0.230678061495142	0.610982666318486	14:102592660-102730576:+	RCOR1	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0017053,cellular_component transcriptional repressor complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070933,biological_process histone H4 deacetylation;GO:1990391,cellular_component DNA repair complex	RCOR1, COREST; REST corepressor 1; K11829	REST corepressor 1 [Source:HGNC Symbol%3BAcc:HGNC:17441]
ENSG00000266733	1.41	2.34	2.45	3.99	1.69	2.97	-0.483796806617684	0.341067598066828	0.230735217719361	0.610982666318486	17:30557111-30563493:+	TBC1D29	NA	NA	TBC1 domain family member 29 [Source:HGNC Symbol%3BAcc:HGNC:24509]
ENSG00000038210	0.83	2.32	1.22	1.19	1.05	1.02	0.386506409066031	0.948319616317515	0.230787089060323	0.610982666318486	4:25233974-25279092:+	PI4K2B	16;GO:0000166,molecular_function nucleotide binding;GO:0004430,molecular_function 1-phosphatidylinositol 4-kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007030,biological_process Golgi organization;GO:0007032,biological_process endosome organization;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046854,biological_process phosphatidylinositol phosphorylation	PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]; K13711	phosphatidylinositol 4-kinase type 2 beta [Source:HGNC Symbol%3BAcc:HGNC:18215]
ENSG00000089818	10.41	15.15	12.19	11.34	11.25	11.15	0.159846149162671	3.55884814198868	0.230798173073985	0.610982666318486	12:8076938-8097859:+	NECAP1	11;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030125,cellular_component clathrin vesicle coat;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0061024,biological_process membrane organization	NA	NECAP endocytosis associated 1 [Source:HGNC Symbol%3BAcc:HGNC:24539]
ENSG00000174233	19.79	21.56	21.37	22.61	20.95	23.38	-0.0840427226909548	6.25973934582902	0.230868247638981	0.61103785883639	12:48766193-48789037:-	ADCY6	34;GO:0000166,molecular_function nucleotide binding;GO:0003091,biological_process renal water homeostasis;GO:0004016,molecular_function adenylate cyclase activity;GO:0004383,molecular_function guanylate cyclase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006171,biological_process cAMP biosynthetic process;GO:0006182,biological_process cGMP biosynthetic process;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0019901,molecular_function protein kinase binding;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0034199,biological_process activation of protein kinase A activity;GO:0035556,biological_process intracellular signal transduction;GO:0035811,biological_process negative regulation of urine volume;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071870,biological_process cellular response to catecholamine stimulus;GO:0097746,biological_process regulation of blood vessel diameter;GO:1904117,biological_process cellular response to vasopressin;GO:1904322,biological_process cellular response to forskolin	ADCY6; adenylate cyclase 6 [EC:4.6.1.1]; K08046	adenylate cyclase 6 [Source:HGNC Symbol%3BAcc:HGNC:237]
ENSG00000177485	9.74	11.05	9.86	8.91	10.38	9.10	0.115964003658771	4.31737284137484	0.231068496370119	0.611437485705029	X:120250751-120258398:+	ZBTB33	17;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008327,molecular_function methyl-CpG binding;GO:0016055,biological_process Wnt signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 33 [Source:HGNC Symbol%3BAcc:HGNC:16682]
ENSG00000188157	177.33	168.10	179.67	168.07	161.02	174.59	0.0720105212867032	10.0902341450201	0.231244913191257	0.611737689741752	1:1020122-1056118:+	AGRN	38;GO:0001523,biological_process retinoid metabolic process;GO:0002162,molecular_function dystroglycan binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005605,cellular_component basal lamina;GO:0005796,cellular_component Golgi lumen;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0031012,cellular_component extracellular matrix;GO:0033691,molecular_function sialic acid binding;GO:0035374,molecular_function chondroitin sulfate binding;GO:0043113,biological_process receptor clustering;GO:0043202,cellular_component lysosomal lumen;GO:0043236,molecular_function laminin binding;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045162,biological_process clustering of voltage-gated sodium channels;GO:0045202,cellular_component synapse;GO:0045887,biological_process positive regulation of synaptic growth at neuromuscular junction;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050808,biological_process synapse organization;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0070062,cellular_component extracellular exosome	AGRN; agrin; K06254	agrin [Source:HGNC Symbol%3BAcc:HGNC:329]
ENSG00000237190	50.64	48.31	51.16	56.36	52.30	54.67	-0.107183070266984	4.26365348191453	0.231280510590352	0.611737689741752	5:134402086-134411898:-	CDKN2AIPNL	3;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0007165,biological_process signal transduction	NA	CDKN2A interacting protein N-terminal like [Source:HGNC Symbol%3BAcc:HGNC:30545]
ENSG00000198692	60.16	52.21	65.42	67.94	59.52	67.06	-0.111684902528413	4.75815635877316	0.23154060006753	0.612133915159943	Y:20575724-20593154:+	EIF1AY	6;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0043023,molecular_function ribosomal large subunit binding	EIF1A; translation initiation factor 1A; K03236	eukaryotic translation initiation factor 1A%2C Y-linked [Source:HGNC Symbol%3BAcc:HGNC:3252]
ENSG00000168818	30.83	33.17	33.07	35.19	36.09	32.98	-0.0927598772484952	5.09960086768839	0.231548860877551	0.612133915159943	4:4415741-4542346:-	STX18	21;GO:0000139,cellular_component Golgi membrane;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019904,molecular_function protein domain specific binding;GO:0031201,cellular_component SNARE complex;GO:0061025,biological_process membrane fusion;GO:0090158,biological_process endoplasmic reticulum membrane organization;GO:1902117,biological_process positive regulation of organelle assembly;GO:1902953,biological_process positive regulation of ER to Golgi vesicle-mediated transport;GO:1903358,biological_process regulation of Golgi organization	STX18; syntaxin 18; K08492	syntaxin 18 [Source:HGNC Symbol%3BAcc:HGNC:15942]
ENSG00000076053	21.41	20.71	21.82	23.36	23.22	22.55	-0.0978861835629386	4.52422011703835	0.231578253894392	0.612133915159943	11:114400029-114414203:+	RBM7	7;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0051321,biological_process meiotic cell cycle	NA	RNA binding motif protein 7 [Source:HGNC Symbol%3BAcc:HGNC:9904]
ENSG00000214367	13.98	12.83	13.89	14.01	14.44	15.59	-0.0984427829135694	4.72290665642623	0.231628539199752	0.612136482241115	4:2227463-2242164:-	HAUS3	20;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:28719]
ENSG00000255529	3.08	2.99	3.26	4.39	3.36	3.21	-0.214326369670178	2.42131712515909	0.231914575503605	0.612761946727597	15:57706628-57782762:+	POLR2M	7;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0032774,biological_process RNA biosynthetic process;GO:0043025,cellular_component neuronal cell body;GO:0051685,biological_process maintenance of ER location	NA	RNA polymerase II subunit M [Source:HGNC Symbol%3BAcc:HGNC:14862]
ENSG00000113593	12.75	10.22	12.92	10.50	11.54	11.33	0.125326155622467	4.55119457316529	0.231995339630389	0.61277043329332	5:65563235-65587549:+	PPWD1	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0006457,biological_process protein folding;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0016853,molecular_function isomerase activity;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	peptidylprolyl isomerase domain and WD repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28954]
ENSG00000163888	6.26	4.03	4.04	2.53	2.24	5.64	0.470976831036349	0.188431954662478	0.2320353944293	0.61277043329332	3:184259212-184261463:-	CAMK2N2	8;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008427,molecular_function calcium-dependent protein kinase inhibitor activity;GO:0019901,molecular_function protein kinase binding	NA	calcium/calmodulin dependent protein kinase II inhibitor 2 [Source:HGNC Symbol%3BAcc:HGNC:24197]
ENSG00000166200	51.60	46.01	49.66	52.04	51.94	53.01	-0.0773816514452651	6.13111601469435	0.232065883099323	0.61277043329332	15:49106067-49155661:-	COPS2	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0003714,molecular_function transcription corepressor activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0008180,cellular_component COP9 signalosome;GO:0008283,biological_process cell proliferation;GO:0022008,biological_process neurogenesis;GO:0030182,biological_process neuron differentiation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043687,biological_process post-translational protein modification;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	COP9 signalosome subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:30747]
ENSG00000130997	0.81	0.85	1.01	0.67	0.96	0.55	0.320207768505831	1.21362768434759	0.232129450224788	0.612807925487089	4:2071917-2242121:-	POLN	17;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019985,biological_process translesion synthesis;GO:0030332,molecular_function cyclin binding;GO:0036297,biological_process interstrand cross-link repair;GO:0071897,biological_process DNA biosynthetic process	POLN; DNA polymerase nu [EC:2.7.7.7]; K16618	DNA polymerase nu [Source:HGNC Symbol%3BAcc:HGNC:18870]
ENSG00000214026	24.93	24.85	25.47	26.50	28.44	26.23	-0.0963859070993625	4.71422718695539	0.232247497682158	0.612989195987376	11:1947277-1984522:+	MRPL23	14;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L23, MRPL23, rplW; large subunit ribosomal protein L23; K02892	mitochondrial ribosomal protein L23 [Source:HGNC Symbol%3BAcc:HGNC:10322]
ENSG00000125611	32.61	32.37	26.12	32.00	31.65	37.43	-0.143627328896536	4.00479710680637	0.232513832819433	0.613561693619817	2:112584239-112589275:+	CHCHD5	3;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0009060,biological_process aerobic respiration	NA	coiled-coil-helix-coiled-coil-helix domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:17840]
ENSG00000198589	6.31	6.63	6.18	6.47	6.87	7.01	-0.0817129456368592	5.84672909923357	0.232612537588111	0.613691695872736	4:150264530-151015727:-	LRBA	8;GO:0003674,molecular_function molecular_function;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	LPS responsive beige-like anchor protein [Source:HGNC Symbol%3BAcc:HGNC:1742]
ENSG00000179023	3.76	4.76	3.69	2.99	4.26	3.50	0.185067454627494	3.17059842969702	0.232713092097783	0.613692046526933	1:18480981-18486126:+	KLHDC7A	5;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch domain containing 7A [Source:HGNC Symbol%3BAcc:HGNC:26791]
ENSG00000169692	80.36	90.29	89.93	95.88	89.21	93.17	-0.0849302073139728	6.2302831626208	0.232735269479345	0.613692046526933	9:136673142-136687423:-	AGPAT2	20;GO:0001819,biological_process positive regulation of cytokine production;GO:0001961,biological_process positive regulation of cytokine-mediated signaling pathway;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008544,biological_process epidermis development;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0035579,cellular_component specific granule membrane;GO:0042493,biological_process response to drug;GO:0043312,biological_process neutrophil degranulation	AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51]; K13509	1-acylglycerol-3-phosphate O-acyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:325]
ENSG00000178467	30.40	26.32	28.83	27.28	26.64	27.46	0.0881774282652018	5.61555736797107	0.232760988886554	0.613692046526933	3:48989885-49007154:+	P4HTM	14;GO:0005506,molecular_function iron ion binding;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0031418,molecular_function L-ascorbic acid binding;GO:0045646,biological_process regulation of erythrocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	prolyl 4-hydroxylase%2C transmembrane [Source:HGNC Symbol%3BAcc:HGNC:28858]
ENSG00000213463	2.76	3.52	4.06	4.82	4.18	4.20	-0.344943809547825	0.896831470522948	0.232882230860494	0.613881319106247	14:70366495-70417061:-	SYNJ2BP	11;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:1903671,biological_process negative regulation of sprouting angiogenesis	NA	synaptojanin 2 binding protein [Source:HGNC Symbol%3BAcc:HGNC:18955]
ENSG00000134265	18.93	17.64	22.27	21.39	21.94	21.09	-0.112752828339218	4.54694853592458	0.233027337491729	0.614022293586028	18:10525904-10552761:+	NAPG	18;GO:0005483,molecular_function soluble NSF attachment protein activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0031201,cellular_component SNARE complex;GO:0043209,cellular_component myelin sheath;GO:0050821,biological_process protein stabilization;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome	NA	NSF attachment protein gamma [Source:HGNC Symbol%3BAcc:HGNC:7642]
ENSG00000139973	0.67	0.65	0.46	0.81	0.79	0.73	-0.377786206805649	0.741525110474485	0.233043977454424	0.614022293586028	14:61811973-62112550:+	SYT16	9;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019905,molecular_function syntaxin binding;GO:0030276,molecular_function clathrin binding	NA	synaptotagmin 16 [Source:HGNC Symbol%3BAcc:HGNC:23142]
ENSG00000166902	46.33	45.31	46.92	50.21	47.24	50.89	-0.0859920711106387	5.17834071186361	0.233084109190152	0.614022293586028	11:59806134-59810872:-	MRPL16	11;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0019843,molecular_function rRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L16, MRPL16, rplP; large subunit ribosomal protein L16; K02878	mitochondrial ribosomal protein L16 [Source:HGNC Symbol%3BAcc:HGNC:14476]
ENSG00000105829	193.51	183.27	194.40	208.16	186.60	215.26	-0.0825434936080555	7.0443524051592	0.233383317000939	0.61468005812278	7:93962761-94004382:-	BET1	19;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030133,cellular_component transport vesicle;GO:0031201,cellular_component SNARE complex;GO:0031985,cellular_component Golgi cisterna;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0048208,biological_process COPII vesicle coating;GO:0048280,biological_process vesicle fusion with Golgi apparatus	BET1; blocked early in transport 1; K08504	Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:14562]
ENSG00000184163	1.25	1.16	1.30	0.91	0.84	0.93	0.481295842690816	0.156762066708025	0.233653854550178	0.615262048479287	1:1242445-1246722:-	C1QTNF12	11;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0010906,biological_process regulation of glucose metabolic process;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045721,biological_process negative regulation of gluconeogenesis;GO:0046324,biological_process regulation of glucose import;GO:0046326,biological_process positive regulation of glucose import;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051897,biological_process positive regulation of protein kinase B signaling	NA	C1q and TNF related 12 [Source:HGNC Symbol%3BAcc:HGNC:32308]
ENSG00000198791	44.75	37.71	39.70	42.57	44.08	44.83	-0.0898145620345728	5.4512296490914	0.233733294689174	0.615340697131859	8:17224963-17246878:-	CNOT7	51;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001191,molecular_function transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004532,molecular_function exoribonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0030014,cellular_component CCR4-NOT complex;GO:0030015,cellular_component CCR4-NOT core complex;GO:0031047,biological_process gene silencing by RNA;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0035195,biological_process gene silencing by miRNA;GO:0042509,biological_process regulation of tyrosine phosphorylation of STAT protein;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060339,biological_process negative regulation of type I interferon-mediated signaling pathway;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0075341,cellular_component host cell PML body;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	CNOT7_8, CAF1, POP2; CCR4-NOT transcription complex subunit 7/8; K12581	CCR4-NOT transcription complex subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:14101]
ENSG00000070423	30.70	31.56	37.22	29.89	29.96	33.21	0.10914114513113	4.9493147335678	0.233812924719276	0.615419812243505	19:647525-663277:-	RNF126	21;GO:0000209,biological_process protein polyubiquitination;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006513,biological_process protein monoubiquitination;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0071629,biological_process cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	NA	ring finger protein 126 [Source:HGNC Symbol%3BAcc:HGNC:21151]
ENSG00000104529	160.19	148.01	148.71	161.16	162.47	160.44	-0.0712049693942559	8.40039267168929	0.233957116834465	0.615489933082604	8:143579696-143599541:-	EEF1D	19;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005853,cellular_component eukaryotic translation elongation factor 1 complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0007165,biological_process signal transduction;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045296,molecular_function cadherin binding;GO:0071479,biological_process cellular response to ionizing radiation	NA	eukaryotic translation elongation factor 1 delta [Source:HGNC Symbol%3BAcc:HGNC:3211]
ENSG00000033011	16.72	19.03	15.02	18.61	17.01	19.83	-0.123515498195843	4.67534336919397	0.23396073465248	0.615489933082604	16:5033959-5087379:+	ALG1	11;GO:0000030,molecular_function mannosyltransferase activity;GO:0004578,molecular_function chitobiosyldiphosphodolichol beta-mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0097502,biological_process mannosylation	ALG1; beta-1,4-mannosyltransferase [EC:2.4.1.142]; K03842	ALG1%2C chitobiosyldiphosphodolichol beta-mannosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:18294]
ENSG00000092140	16.12	16.58	16.27	16.68	17.72	17.93	-0.0860618209715754	5.22722730095264	0.233988318232241	0.615489933082604	14:30559122-30620063:+	G2E3	10;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	G2/M-phase specific E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:20338]
ENSG00000177683	24.56	21.45	23.35	19.90	20.67	24.21	0.113159761115825	4.73910579331692	0.234090811828861	0.615629077803315	7:108554542-108569750:-	THAP5	9;GO:0002020,molecular_function protease binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0045786,biological_process negative regulation of cell cycle;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:23188]
ENSG00000145388	17.51	18.00	18.00	15.82	18.06	16.46	0.0995417397215177	4.73365793953605	0.234231389893524	0.615868299671323	4:118685367-118715433:+	METTL14	16;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016070,biological_process RNA metabolic process;GO:0016422,molecular_function mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0019827,biological_process stem cell population maintenance;GO:0032259,biological_process methylation;GO:0036396,cellular_component MIS complex;GO:0061157,biological_process mRNA destabilization;GO:0080009,biological_process mRNA methylation	NA	methyltransferase like 14 [Source:HGNC Symbol%3BAcc:HGNC:29330]
ENSG00000150753	322.52	337.70	308.89	345.61	345.01	336.43	-0.0722911481829394	9.19727027706948	0.23435118761741	0.615964170620632	5:10249920-10266412:+	CCT5	32;GO:0000166,molecular_function nucleotide binding;GO:0002199,cellular_component zona pellucida receptor complex;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0009615,biological_process response to virus;GO:0031681,molecular_function G-protein beta-subunit binding;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0043209,cellular_component myelin sheath;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044297,cellular_component cell body;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0048487,molecular_function beta-tubulin binding;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:1901998,biological_process toxin transport;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	chaperonin containing TCP1 subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:1618]
ENSG00000083750	19.83	20.53	21.19	19.02	17.78	20.74	0.106535696429153	4.48713399163605	0.234418797070399	0.615964170620632	X:55717738-55758774:+	RRAGB	24;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0007050,biological_process cell cycle arrest;GO:0010506,biological_process regulation of autophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0032006,biological_process regulation of TOR signaling;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032561,molecular_function guanyl ribonucleotide binding;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034448,cellular_component EGO complex;GO:0034613,biological_process cellular protein localization;GO:0046982,molecular_function protein heterodimerization activity;GO:0051020,molecular_function GTPase binding;GO:0071230,biological_process cellular response to amino acid stimulus;GO:1904263,biological_process positive regulation of TORC1 signaling;GO:1990131,cellular_component Gtr1-Gtr2 GTPase complex;GO:1990253,biological_process cellular response to leucine starvation	RRAGA_B; Ras-related GTP-binding protein A/B; K16185	Ras related GTP binding B [Source:HGNC Symbol%3BAcc:HGNC:19901]
ENSG00000215712	32.81	30.26	25.76	33.38	31.13	33.69	-0.133949778859003	3.9201999374703	0.234440454435585	0.615964170620632	6:157289385-157323601:-	TMEM242	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 242 [Source:HGNC Symbol%3BAcc:HGNC:17206]
ENSG00000089050	22.66	21.07	22.69	24.42	24.06	24.57	-0.1211302788972	3.71804361095352	0.234466342236565	0.615964170620632	20:18486539-18497243:-	RBBP9	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0016787,molecular_function hydrolase activity;GO:0042127,biological_process regulation of cell proliferation;GO:0070062,cellular_component extracellular exosome	NA	RB binding protein 9%2C serine hydrolase [Source:HGNC Symbol%3BAcc:HGNC:9892]
ENSG00000113163	16.65	13.85	17.03	16.36	17.25	17.92	-0.0981609563527847	5.22987407903384	0.234609929632341	0.616097845933144	5:75368485-75512138:-	COL4A3BP	32;GO:0000902,biological_process cell morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0003007,biological_process heart morphogenesis;GO:0005515,molecular_function protein binding;GO:0005581,cellular_component collagen trimer;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006672,biological_process ceramide metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006936,biological_process muscle contraction;GO:0006955,biological_process immune response;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0008289,molecular_function lipid binding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035621,biological_process ER to Golgi ceramide transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055088,biological_process lipid homeostasis;GO:0070584,biological_process mitochondrion morphogenesis;GO:0097001,molecular_function ceramide binding;GO:0120012,biological_process intermembrane sphingolipid transfer;GO:0120017,molecular_function intermembrane ceramide transfer activity	NA	collagen type IV alpha 3 binding protein [Source:HGNC Symbol%3BAcc:HGNC:2205]
ENSG00000249590	1.04	1.41	0.91	1.97	0.87	1.62	-0.41951524784404	0.795406293187141	0.234616492203816	0.616097845933144	22:30409254-30428990:+	AC004832.3	2;GO:0006810,biological_process transport;GO:0016021,cellular_component integral component of membrane	NA	NA
ENSG00000162931	0.49	0.67	0.51	1.09	0.62	0.62	-0.48763153105529	0.267328545614009	0.234698641686143	0.616183214731408	1:228407939-228416861:-	TRIM17	12;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0006914,biological_process autophagy;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030674,molecular_function protein binding, bridging;GO:0032880,biological_process regulation of protein localization;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination	NA	tripartite motif containing 17 [Source:HGNC Symbol%3BAcc:HGNC:13430]
ENSG00000155660	287.94	322.18	274.54	268.44	303.11	265.07	0.0920213178208066	9.22147352679227	0.234782669950362	0.616273478979456	7:149003061-149028641:-	PDIA4	17;GO:0003723,molecular_function RNA binding;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006457,biological_process protein folding;GO:0009306,biological_process protein secretion;GO:0009986,cellular_component cell surface;GO:0015037,molecular_function peptide disulfide oxidoreductase activity;GO:0016853,molecular_function isomerase activity;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042470,cellular_component melanosome;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0061077,biological_process chaperone-mediated protein folding	PDIA4, ERP72; protein disulfide-isomerase A4 [EC:5.3.4.1]; K09582	protein disulfide isomerase family A member 4 [Source:HGNC Symbol%3BAcc:HGNC:30167]
ENSG00000091622	1.08	0.85	1.35	1.00	0.85	0.91	0.281972677966071	1.6447890881849	0.234947380496964	0.616554769785926	17:6451263-6556494:-	PITPNM3	15;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0008526,molecular_function phosphatidylinositol transporter activity;GO:0012505,cellular_component endomembrane system;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046872,molecular_function metal ion binding	NA	PITPNM family member 3 [Source:HGNC Symbol%3BAcc:HGNC:21043]
ENSG00000171867	112.59	104.88	115.98	111.37	99.32	106.91	0.0837098831823572	6.36813563774781	0.234994963852887	0.616554769785926	20:4686235-4701590:+	PRNP	86;GO:0001540,molecular_function beta-amyloid binding;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002020,molecular_function protease binding;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006878,biological_process cellular copper ion homeostasis;GO:0006979,biological_process response to oxidative stress;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007611,biological_process learning or memory;GO:0007616,biological_process long-term memory;GO:0008017,molecular_function microtubule binding;GO:0008152,biological_process metabolic process;GO:0009986,cellular_component cell surface;GO:0010942,biological_process positive regulation of cell death;GO:0010955,biological_process negative regulation of protein processing;GO:0014069,cellular_component postsynaptic density;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016234,cellular_component inclusion body;GO:0019898,cellular_component extrinsic component of membrane;GO:0030425,cellular_component dendrite;GO:0031225,cellular_component anchored component of membrane;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0031648,biological_process protein destabilization;GO:0031802,molecular_function type 5 metabotropic glutamate receptor binding;GO:0031965,cellular_component nuclear membrane;GO:0032147,biological_process activation of protein kinase activity;GO:0032403,molecular_function protein complex binding;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032700,biological_process negative regulation of interleukin-17 production;GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0032880,biological_process regulation of protein localization;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0035690,biological_process cellular response to drug;GO:0042802,molecular_function identical protein binding;GO:0043008,molecular_function ATP-dependent protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0044325,molecular_function ion channel binding;GO:0045121,cellular_component membrane raft;GO:0046007,biological_process negative regulation of activated T cell proliferation;GO:0046686,biological_process response to cadmium ion;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0051087,molecular_function chaperone binding;GO:0051260,biological_process protein homooligomerization;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070885,biological_process negative regulation of calcineurin-NFAT signaling cascade;GO:0071280,biological_process cellular response to copper ion;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0090647,biological_process modulation of age-related behavioral decline;GO:0098794,cellular_component postsynapse;GO:0106003,cellular_component amyloid-beta complex;GO:1900272,biological_process negative regulation of long-term synaptic potentiation;GO:1901216,biological_process positive regulation of neuron death;GO:1901379,biological_process regulation of potassium ion transmembrane transport;GO:1902430,biological_process negative regulation of beta-amyloid formation;GO:1902938,biological_process regulation of intracellular calcium activated chloride channel activity;GO:1902951,biological_process negative regulation of dendritic spine maintenance;GO:1902992,biological_process negative regulation of amyloid precursor protein catabolic process;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:1903135,molecular_function cupric ion binding;GO:1903136,molecular_function cuprous ion binding;GO:1904645,biological_process response to beta-amyloid;GO:1904646,biological_process cellular response to beta-amyloid;GO:1905664,biological_process regulation of calcium ion import across plasma membrane;GO:1990535,biological_process neuron projection maintenance	PRNP, PrP, CD230; prion protein; K05634	prion protein [Source:HGNC Symbol%3BAcc:HGNC:9449]
ENSG00000273706	7.60	7.18	7.40	8.86	6.37	10.07	-0.17930295631487	3.6600562243166	0.235039456647025	0.616554769785926	17:36936784-36944612:+	LHX1	82;GO:0001655,biological_process urogenital system development;GO:0001656,biological_process metanephros development;GO:0001657,biological_process ureteric bud development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001705,biological_process ectoderm formation;GO:0001706,biological_process endoderm formation;GO:0001822,biological_process kidney development;GO:0001823,biological_process mesonephros development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0007399,biological_process nervous system development;GO:0008045,biological_process motor neuron axon guidance;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009791,biological_process post-embryonic development;GO:0009880,biological_process embryonic pattern specification;GO:0009887,biological_process organ morphogenesis;GO:0009948,biological_process anterior/posterior axis specification;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0010842,biological_process retina layer formation;GO:0021510,biological_process spinal cord development;GO:0021517,biological_process ventral spinal cord development;GO:0021527,biological_process spinal cord association neuron differentiation;GO:0021537,biological_process telencephalon development;GO:0021549,biological_process cerebellum development;GO:0021702,biological_process cerebellar Purkinje cell differentiation;GO:0021871,biological_process forebrain regionalization;GO:0021937,biological_process cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation;GO:0030154,biological_process cell differentiation;GO:0032525,biological_process somite rostral/caudal axis specification;GO:0035502,biological_process metanephric part of ureteric bud development;GO:0035846,biological_process oviduct epithelium development;GO:0035847,biological_process uterine epithelium development;GO:0035849,biological_process nephric duct elongation;GO:0035852,biological_process horizontal cell localization;GO:0040019,biological_process positive regulation of embryonic development;GO:0043234,cellular_component protein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0048793,biological_process pronephros development;GO:0060041,biological_process retina development in camera-type eye;GO:0060059,biological_process embryonic retina morphogenesis in camera-type eye;GO:0060065,biological_process uterus development;GO:0060066,biological_process oviduct development;GO:0060067,biological_process cervix development;GO:0060068,biological_process vagina development;GO:0060322,biological_process head development;GO:0060429,biological_process epithelium development;GO:0061205,biological_process paramesonephric duct development;GO:0072001,biological_process renal system development;GO:0072049,biological_process comma-shaped body morphogenesis;GO:0072050,biological_process S-shaped body morphogenesis;GO:0072077,biological_process renal vesicle morphogenesis;GO:0072164,biological_process mesonephric tubule development;GO:0072177,biological_process mesonephric duct development;GO:0072178,biological_process nephric duct morphogenesis;GO:0072224,biological_process metanephric glomerulus development;GO:0072278,biological_process metanephric comma-shaped body morphogenesis;GO:0072283,biological_process metanephric renal vesicle morphogenesis;GO:0072284,biological_process metanephric S-shaped body morphogenesis;GO:0090009,biological_process primitive streak formation;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0097477,biological_process lateral motor column neuron migration;GO:2000543,biological_process positive regulation of gastrulation;GO:2000744,biological_process positive regulation of anterior head development;GO:2000768,biological_process positive regulation of nephron tubule epithelial cell differentiation	NA	LIM homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:6593]
ENSG00000139668	5.09	4.82	6.25	4.86	4.74	4.79	0.188016676489022	2.70529871154057	0.235138034705937	0.616554769785926	13:51584454-51767707:+	WDFY2	8;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0031982,cellular_component vesicle;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0046872,molecular_function metal ion binding	NA	WD repeat and FYVE domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20482]
ENSG00000110696	204.62	194.54	202.53	207.31	211.84	219.08	-0.0725606201190696	7.18138954008572	0.235173539813036	0.616554769785926	11:16613131-16756881:+	C11orf58	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	chromosome 11 open reading frame 58 [Source:HGNC Symbol%3BAcc:HGNC:16990]
ENSG00000163399	186.22	189.93	179.54	180.03	176.42	177.79	0.0683823669360578	9.13870381769377	0.235226305177895	0.616554769785926	1:116372667-116410261:+	ATP1A1	68;GO:0000166,molecular_function nucleotide binding;GO:0002026,biological_process regulation of the force of heart contraction;GO:0002028,biological_process regulation of sodium ion transport;GO:0005391,molecular_function sodium:potassium-exchanging ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005890,cellular_component sodium:potassium-exchanging ATPase complex;GO:0005901,cellular_component caveola;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0008217,biological_process regulation of blood pressure;GO:0010107,biological_process potassium ion import;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0014069,cellular_component postsynaptic density;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030007,biological_process cellular potassium ion homeostasis;GO:0030315,cellular_component T-tubule;GO:0030506,molecular_function ankyrin binding;GO:0030955,molecular_function potassium ion binding;GO:0031402,molecular_function sodium ion binding;GO:0031947,biological_process negative regulation of glucocorticoid biosynthetic process;GO:0034220,biological_process ion transmembrane transport;GO:0036376,biological_process sodium ion export from cell;GO:0042383,cellular_component sarcolemma;GO:0042470,cellular_component melanosome;GO:0042493,biological_process response to drug;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043531,molecular_function ADP binding;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0045121,cellular_component membrane raft;GO:0045822,biological_process negative regulation of heart contraction;GO:0045823,biological_process positive regulation of heart contraction;GO:0045989,biological_process positive regulation of striated muscle contraction;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060081,biological_process membrane hyperpolarization;GO:0070062,cellular_component extracellular exosome;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0086002,biological_process cardiac muscle cell action potential involved in contraction;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:0086009,biological_process membrane repolarization;GO:0086013,biological_process membrane repolarization during cardiac muscle cell action potential;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0090662,biological_process ATP hydrolysis coupled transmembrane transport;GO:1903416,biological_process response to glycoside;GO:1903561,cellular_component extracellular vesicle;GO:1903779,biological_process regulation of cardiac conduction;GO:1990239,molecular_function steroid hormone binding;GO:1990573,biological_process potassium ion import across plasma membrane	ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]; K01539	ATPase Na+/K+ transporting subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:799]
ENSG00000100744	57.08	54.09	48.18	46.86	53.29	48.23	0.11464296918201	4.4281596843243	0.235334214972404	0.616554769785926	14:96363451-96387288:+	GSKIP	1;GO:0005737,cellular_component cytoplasm	NA	GSK3B interacting protein [Source:HGNC Symbol%3BAcc:HGNC:20343]
ENSG00000103168	16.86	16.39	18.13	16.85	15.95	16.07	0.0866821459493933	5.4664668751042	0.23536960942596	0.616554769785926	16:84177846-84187070:-	TAF1C	17;GO:0000120,cellular_component RNA polymerase I transcription factor complex;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006356,biological_process regulation of transcription from RNA polymerase I promoter;GO:0006360,biological_process transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045815,biological_process positive regulation of gene expression, epigenetic	NA	TATA-box binding protein associated factor%2C RNA polymerase I subunit C [Source:HGNC Symbol%3BAcc:HGNC:11534]
ENSG00000138756	11.96	12.07	11.45	11.25	11.54	10.98	0.082237339876943	5.36632699427911	0.235379018788337	0.616554769785926	4:78776341-78916372:+	BMP2K	17;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019208,molecular_function phosphatase regulator activity;GO:0030500,biological_process regulation of bone mineralization;GO:0035612,molecular_function AP-2 adaptor complex binding;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0050790,biological_process regulation of catalytic activity;GO:2000369,biological_process regulation of clathrin-mediated endocytosis	BMP2K, BIKE; BMP2 inducible kinase [EC:2.7.11.1]; K08854	BMP2 inducible kinase [Source:HGNC Symbol%3BAcc:HGNC:18041]
ENSG00000120533	245.17	248.75	227.74	252.86	255.19	259.29	-0.0779185101109859	6.6469238294419	0.235469945537428	0.616554769785926	8:109334323-109345953:+	ENY2	23;GO:0000124,cellular_component SAGA complex;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016569,biological_process covalent chromatin modification;GO:0016578,biological_process histone deubiquitination;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051028,biological_process mRNA transport;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070390,cellular_component transcription export complex 2;GO:0071819,cellular_component DUBm complex	NA	ENY2%2C transcription and export complex 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:24449]
ENSG00000006062	18.94	18.36	18.93	17.09	16.80	19.49	0.0867599513227409	5.71137102955845	0.235475202058823	0.616554769785926	17:45263120-45317040:-	MAP3K14	31;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001650,cellular_component fibrillar center;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004704,molecular_function NF-kappaB-inducing kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031295,biological_process T cell costimulation;GO:0032147,biological_process activation of protein kinase activity;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051607,biological_process defense response to virus;GO:0071260,biological_process cellular response to mechanical stimulus	MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]; K04466	mitogen-activated protein kinase kinase kinase 14 [Source:HGNC Symbol%3BAcc:HGNC:6853]
ENSG00000171222	55.11	59.26	51.53	52.42	51.69	51.99	0.0943730709947448	4.85453722672985	0.235485874772825	0.616554769785926	20:35953616-35959472:-	SCAND1	6;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042802,molecular_function identical protein binding	NA	SCAN domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:10566]
ENSG00000169660	9.29	8.97	9.32	9.98	9.35	10.51	-0.100968681179893	4.53921893836001	0.235687937027004	0.616953682479166	17:82418317-82442645:+	HEXDC	10;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004563,molecular_function beta-N-acetylhexosaminidase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005975,biological_process carbohydrate metabolic process;GO:0008152,biological_process metabolic process;GO:0015929,molecular_function hexosaminidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0102148,molecular_function N-acetyl-beta-D-galactosaminidase activity	HEX; hexosaminidase [EC:3.2.1.52]; K14459	hexosaminidase D [Source:HGNC Symbol%3BAcc:HGNC:26307]
ENSG00000166153	1.70	0.64	1.65	1.74	1.64	1.81	-0.318255878478261	1.02599779428717	0.235755014828117	0.616999156454021	12:100203668-100267079:-	DEPDC4	3;GO:0005622,cellular_component intracellular;GO:0007165,biological_process signal transduction;GO:0035556,biological_process intracellular signal transduction	NA	DEP domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:22952]
ENSG00000164292	13.82	12.68	13.88	12.96	13.30	11.86	0.100487180196673	4.89059440329987	0.235901960799803	0.617204392150049	5:95713521-95824383:+	RHOBTB3	17;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008584,biological_process male gonad development;GO:0016192,biological_process vesicle-mediated transport;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0070062,cellular_component extracellular exosome	NA	Rho related BTB domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:18757]
ENSG00000136783	32.88	36.88	36.06	37.99	38.28	37.67	-0.0991531774195685	4.77038332786487	0.235932880105694	0.617204392150049	9:104747687-104760122:+	NIPSNAP3A	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol	NA	nipsnap homolog 3A [Source:HGNC Symbol%3BAcc:HGNC:23619]
ENSG00000187736	6.69	5.71	6.84	7.88	6.54	7.53	-0.168928280930533	2.89487734066209	0.23609371896256	0.617323073413535	2:219075316-219160865:-	NHEJ1	17;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007417,biological_process central nervous system development;GO:0010212,biological_process response to ionizing radiation;GO:0030183,biological_process B cell differentiation;GO:0030217,biological_process T cell differentiation;GO:0032807,cellular_component DNA ligase IV complex;GO:0045027,molecular_function DNA end binding;GO:0051351,biological_process positive regulation of ligase activity;GO:0070419,cellular_component nonhomologous end joining complex	NHEJ1, XLF; non-homologous end-joining factor 1; K10980	non-homologous end joining factor 1 [Source:HGNC Symbol%3BAcc:HGNC:25737]
ENSG00000170955	47.65	46.10	40.86	49.66	45.30	49.84	-0.0951111819953603	5.36170408861646	0.236133109131139	0.617323073413535	11:6318945-6320647:-	CAVIN3	13;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005901,cellular_component caveola;GO:0016020,cellular_component membrane;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0032922,biological_process circadian regulation of gene expression;GO:0043234,cellular_component protein complex;GO:0048511,biological_process rhythmic process;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:1901003,biological_process negative regulation of fermentation	NA	caveolae associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:9400]
ENSG00000109846	8.13	12.95	9.13	7.28	10.47	8.09	0.222646112758775	2.87995098733749	0.236159729355412	0.617323073413535	11:111908564-111923722:-	CRYAB	58;GO:0001666,biological_process response to hypoxia;GO:0002088,biological_process lens development in camera-type eye;GO:0005212,molecular_function structural constituent of eye lens;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006936,biological_process muscle contraction;GO:0007021,biological_process tubulin complex assembly;GO:0007517,biological_process muscle organ development;GO:0007568,biological_process aging;GO:0008017,molecular_function microtubule binding;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009986,cellular_component cell surface;GO:0010629,biological_process negative regulation of gene expression;GO:0010941,biological_process regulation of cell death;GO:0014069,cellular_component postsynaptic density;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030018,cellular_component Z disc;GO:0030308,biological_process negative regulation of cell growth;GO:0030424,cellular_component axon;GO:0031109,biological_process microtubule polymerization or depolymerization;GO:0031430,cellular_component M band;GO:0031674,cellular_component I band;GO:0032355,biological_process response to estradiol;GO:0032387,biological_process negative regulation of intracellular transport;GO:0032403,molecular_function protein complex binding;GO:0032432,cellular_component actin filament bundle;GO:0032463,biological_process negative regulation of protein homooligomerization;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043010,biological_process camera-type eye development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0043204,cellular_component perikaryon;GO:0043209,cellular_component myelin sheath;GO:0043292,cellular_component contractile fiber;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051260,biological_process protein homooligomerization;GO:0051403,biological_process stress-activated MAPK cascade;GO:0060561,biological_process apoptotic process involved in morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071480,biological_process cellular response to gamma radiation;GO:0097060,cellular_component synaptic membrane;GO:0097512,cellular_component cardiac myofibril;GO:1900034,biological_process regulation of cellular response to heat;GO:1905907,biological_process negative regulation of amyloid fibril formation;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	CRYAB; crystallin, alpha B; K09542	crystallin alpha B [Source:HGNC Symbol%3BAcc:HGNC:2389]
ENSG00000146072	15.74	14.69	15.51	17.72	14.98	16.96	-0.0983976382511325	4.97837796070367	0.236199674425913	0.617323073413535	6:47231531-47309905:-	TNFRSF21	34;GO:0001783,biological_process B cell apoptotic process;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0006959,biological_process humoral immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030424,cellular_component axon;GO:0030889,biological_process negative regulation of B cell proliferation;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031642,biological_process negative regulation of myelination;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042552,biological_process myelination;GO:0042981,biological_process regulation of apoptotic process;GO:0048713,biological_process regulation of oligodendrocyte differentiation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051402,biological_process neuron apoptotic process;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0097190,biological_process apoptotic signaling pathway;GO:0097252,biological_process oligodendrocyte apoptotic process;GO:2000663,biological_process negative regulation of interleukin-5 secretion;GO:2000666,biological_process negative regulation of interleukin-13 secretion;GO:2001180,biological_process negative regulation of interleukin-10 secretion	TNFRSF21, DR6, CD358; tumor necrosis factor receptor superfamily member 21; K05157	TNF receptor superfamily member 21 [Source:HGNC Symbol%3BAcc:HGNC:13469]
ENSG00000049759	14.78	16.17	13.70	15.18	17.67	15.27	-0.0985145332823901	5.98727592335905	0.236226907171054	0.617323073413535	18:58044366-58401540:+	NEDD4L	51;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000209,biological_process protein polyubiquitination;GO:0003254,biological_process regulation of membrane depolarization;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005771,cellular_component multivesicular body;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0006814,biological_process sodium ion transport;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0007588,biological_process excretion;GO:0010038,biological_process response to metal ion;GO:0015459,molecular_function potassium channel regulator activity;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0017080,molecular_function sodium channel regulator activity;GO:0019058,biological_process viral life cycle;GO:0019870,molecular_function potassium channel inhibitor activity;GO:0019871,molecular_function sodium channel inhibitor activity;GO:0030104,biological_process water homeostasis;GO:0030154,biological_process cell differentiation;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042176,biological_process regulation of protein catabolic process;GO:0042391,biological_process regulation of membrane potential;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044325,molecular_function ion channel binding;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045807,biological_process positive regulation of endocytosis;GO:0060306,biological_process regulation of membrane repolarization;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0086005,biological_process ventricular cardiac muscle cell action potential;GO:1901016,biological_process regulation of potassium ion transmembrane transporter activity;GO:1901017,biological_process negative regulation of potassium ion transmembrane transporter activity;GO:1901380,biological_process negative regulation of potassium ion transmembrane transport;GO:1902306,biological_process negative regulation of sodium ion transmembrane transport;GO:1903861,biological_process positive regulation of dendrite extension;GO:2000009,biological_process negative regulation of protein localization to cell surface;GO:2000650,biological_process negative regulation of sodium ion transmembrane transporter activity;GO:2001288,biological_process positive regulation of caveolin-mediated endocytosis	NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]; K13305	neural precursor cell expressed%2C developmentally down-regulated 4-like%2C E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:7728]
ENSG00000150551	22.72	23.00	20.45	21.95	17.76	20.16	0.152038262193139	3.28332189319458	0.23630350392045	0.617393263347621	2:132644852-132671579:-	LYPD1	14;GO:0001662,biological_process behavioral fear response;GO:0001775,biological_process cell activation;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0016020,cellular_component membrane;GO:0030550,molecular_function acetylcholine receptor inhibitor activity;GO:0031225,cellular_component anchored component of membrane;GO:0033130,molecular_function acetylcholine receptor binding;GO:0035094,biological_process response to nicotine;GO:0095500,biological_process acetylcholine receptor signaling pathway;GO:1903077,biological_process negative regulation of protein localization to plasma membrane;GO:2000272,biological_process negative regulation of receptor activity	NA	LY6/PLAUR domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28431]
ENSG00000163159	37.42	38.99	39.91	41.33	44.16	39.13	-0.0875653037058702	5.50306533643815	0.236426834008466	0.617489270615316	1:151169986-151195321:-	VPS72	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042393,molecular_function histone binding;GO:0043234,cellular_component protein complex;GO:0043486,biological_process histone exchange	NA	vacuolar protein sorting 72 homolog [Source:HGNC Symbol%3BAcc:HGNC:11644]
ENSG00000116690	0.75	0.88	0.75	0.52	0.77	0.72	0.25091661078535	1.6869909317515	0.236439740855119	0.617489270615316	1:186296278-186314562:+	PRG4	6;GO:0005044,molecular_function scavenger receptor activity;GO:0005576,cellular_component extracellular region;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006955,biological_process immune response;GO:0008283,biological_process cell proliferation;GO:0030247,molecular_function polysaccharide binding	NA	proteoglycan 4 [Source:HGNC Symbol%3BAcc:HGNC:9364]
ENSG00000082458	0.63	0.34	0.29	0.51	0.63	0.58	-0.397485418526732	0.638738602755305	0.236540204223126	0.617494288740781	X:70444860-70505490:+	DLG3	37;GO:0001736,biological_process establishment of planar polarity;GO:0004385,molecular_function guanylate kinase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0014069,cellular_component postsynaptic density;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0016323,cellular_component basolateral plasma membrane;GO:0019900,molecular_function kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030165,molecular_function PDZ domain binding;GO:0030426,cellular_component growth cone;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0034220,biological_process ion transmembrane transport;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0043025,cellular_component neuronal cell body;GO:0043113,biological_process receptor clustering;GO:0043198,cellular_component dendritic shaft;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0097120,biological_process receptor localization to synapse	DLG2; discs large protein 2; K12075	discs large MAGUK scaffold protein 3 [Source:HGNC Symbol%3BAcc:HGNC:2902]
ENSG00000171960	22.96	27.45	27.29	27.95	30.89	26.35	-0.124972235498683	4.38739858172739	0.236541153867914	0.617494288740781	1:42658424-42676758:+	PPIH	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006457,biological_process protein folding;GO:0006461,biological_process protein complex assembly;GO:0008380,biological_process RNA splicing;GO:0016018,molecular_function cyclosporin A binding;GO:0016607,cellular_component nuclear speck;GO:0016853,molecular_function isomerase activity;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0045070,biological_process positive regulation of viral genome replication;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071001,cellular_component U4/U6 snRNP	PPIH, CYPH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]; K09567	peptidylprolyl isomerase H [Source:HGNC Symbol%3BAcc:HGNC:14651]
ENSG00000087088	59.82	56.04	59.67	58.43	55.55	53.23	0.0847476868217723	5.61748928241941	0.236691872156331	0.617757823607347	19:48954814-48961798:+	BAX	135;GO:0001541,biological_process ovarian follicle development;GO:0001764,biological_process neuron migration;GO:0001776,biological_process leukocyte homeostasis;GO:0001777,biological_process T cell homeostatic proliferation;GO:0001782,biological_process B cell homeostasis;GO:0001783,biological_process B cell apoptotic process;GO:0001822,biological_process kidney development;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001844,biological_process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0001974,biological_process blood vessel remodeling;GO:0002262,biological_process myeloid cell homeostasis;GO:0002352,biological_process B cell negative selection;GO:0002358,biological_process B cell homeostatic proliferation;GO:0002904,biological_process positive regulation of B cell apoptotic process;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005757,cellular_component mitochondrial permeability transition pore complex;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006808,biological_process regulation of nitrogen utilization;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0007281,biological_process germ cell development;GO:0007283,biological_process spermatogenesis;GO:0007399,biological_process nervous system development;GO:0007548,biological_process sex differentiation;GO:0008053,biological_process mitochondrial fusion;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008584,biological_process male gonad development;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009566,biological_process fertilization;GO:0009611,biological_process response to wounding;GO:0009636,biological_process response to toxic substance;GO:0009651,biological_process response to salt stress;GO:0009791,biological_process post-embryonic development;GO:0010212,biological_process response to ionizing radiation;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0010332,biological_process response to gamma radiation;GO:0010524,biological_process positive regulation of calcium ion transport into cytosol;GO:0015267,molecular_function channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0021854,biological_process hypothalamus development;GO:0021987,biological_process cerebral cortex development;GO:0030544,molecular_function Hsp70 protein binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032091,biological_process negative regulation of protein binding;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0032976,biological_process release of matrix enzymes from mitochondria;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0033599,biological_process regulation of mammary gland epithelial cell proliferation;GO:0034644,biological_process cellular response to UV;GO:0035108,biological_process limb morphogenesis;GO:0035234,biological_process ectopic germ cell programmed cell death;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043281,biological_process regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043496,biological_process regulation of protein homodimerization activity;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0045136,biological_process development of secondary sexual characteristics;GO:0046666,biological_process retinal cell programmed cell death;GO:0046930,cellular_component pore complex;GO:0046982,molecular_function protein heterodimerization activity;GO:0048087,biological_process positive regulation of developmental pigmentation;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0048515,biological_process spermatid differentiation;GO:0048597,biological_process post-embryonic camera-type eye morphogenesis;GO:0048678,biological_process response to axon injury;GO:0048872,biological_process homeostasis of number of cells;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0051087,molecular_function chaperone binding;GO:0051259,biological_process protein oligomerization;GO:0051260,biological_process protein homooligomerization;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0051402,biological_process neuron apoptotic process;GO:0051434,molecular_function BH3 domain binding;GO:0051726,biological_process regulation of cell cycle;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0060011,biological_process Sertoli cell proliferation;GO:0060041,biological_process retina development in camera-type eye;GO:0060058,biological_process positive regulation of apoptotic process involved in mammary gland involution;GO:0060068,biological_process vagina development;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070062,cellular_component extracellular exosome;GO:0070242,biological_process thymocyte apoptotic process;GO:0070584,biological_process mitochondrion morphogenesis;GO:0071310,biological_process cellular response to organic substance;GO:0071944,cellular_component cell periphery;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097136,cellular_component Bcl-2 family protein complex;GO:0097144,cellular_component BAX complex;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1900103,biological_process positive regulation of endoplasmic reticulum unfolded protein response;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1902108,biological_process regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1902110,biological_process positive regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1902262,biological_process apoptotic process involved in patterning of blood vessels;GO:1902263,biological_process apoptotic process involved in embryonic digit morphogenesis;GO:1902445,biological_process regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:1902512,biological_process positive regulation of apoptotic DNA fragmentation;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response;GO:1990117,biological_process B cell receptor apoptotic signaling pathway;GO:2001234,biological_process negative regulation of apoptotic signaling pathway;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BAX; apoptosis regulator BAX; K02159	BCL2 associated X%2C apoptosis regulator [Source:HGNC Symbol%3BAcc:HGNC:959]
ENSG00000167969	76.16	65.61	74.49	76.03	70.99	86.46	-0.0963501589981259	6.091994025965	0.236833787040236	0.617998275915589	16:2239394-2252300:-	ECI1	13;GO:0003824,molecular_function catalytic activity;GO:0004165,molecular_function dodecenoyl-CoA delta-isomerase activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016853,molecular_function isomerase activity;GO:0016860,molecular_function intramolecular oxidoreductase activity;GO:0070062,cellular_component extracellular exosome	ECI1, DCI; Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]; K13238	enoyl-CoA delta isomerase 1 [Source:HGNC Symbol%3BAcc:HGNC:2703]
ENSG00000184014	39.05	36.31	39.53	39.80	41.35	40.85	-0.0735778395811642	7.29289240123378	0.236927121135416	0.61810186079234	11:9138824-9265390:-	DENND5A	16;GO:0000139,cellular_component Golgi membrane;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005262,molecular_function calcium channel activity;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030904,cellular_component retromer complex;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050982,biological_process detection of mechanical stimulus;GO:0061024,biological_process membrane organization;GO:0070588,biological_process calcium ion transmembrane transport	NA	DENN domain containing 5A [Source:HGNC Symbol%3BAcc:HGNC:19344]
ENSG00000204227	41.29	40.25	45.26	38.67	38.61	43.01	0.0891474917142353	5.65444084189445	0.236973073029143	0.61810186079234	6:33208494-33212722:+	RING1	24;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001739,cellular_component sex chromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016574,biological_process histone ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex;GO:0035518,biological_process histone H2A monoubiquitination;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050790,biological_process regulation of catalytic activity;GO:0097027,molecular_function ubiquitin-protein transferase activator activity	NA	ring finger protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10018]
ENSG00000104783	13.91	8.61	11.18	15.07	9.76	14.36	-0.198869115344988	4.08927562971557	0.237136874050159	0.618399163358114	19:43766532-43781257:-	KCNN4	25;GO:0002376,biological_process immune system process;GO:0005267,molecular_function potassium channel activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006816,biological_process calcium ion transport;GO:0006884,biological_process cell volume homeostasis;GO:0006952,biological_process defense response;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015269,molecular_function calcium-activated potassium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016286,molecular_function small conductance calcium-activated potassium channel activity;GO:0019903,molecular_function protein phosphatase binding;GO:0030322,biological_process stabilization of membrane potential;GO:0031982,cellular_component vesicle;GO:0043025,cellular_component neuronal cell body;GO:0045332,biological_process phospholipid translocation;GO:0046541,biological_process saliva secretion;GO:0050714,biological_process positive regulation of protein secretion;GO:0050862,biological_process positive regulation of T cell receptor signaling pathway;GO:0071805,biological_process potassium ion transmembrane transport	KCNN4, KCA3.1; potassium intermediate/small conductance calcium-activated channel subfamily N member 4; K04945	potassium calcium-activated channel subfamily N member 4 [Source:HGNC Symbol%3BAcc:HGNC:6293]
ENSG00000076248	18.54	16.11	19.32	19.65	19.25	20.07	-0.108319836139131	4.31320426886001	0.237323644100689	0.618417753538588	12:109097573-109110992:+	UNG	19;GO:0003684,molecular_function damaged DNA binding;GO:0004844,molecular_function uracil DNA N-glycosylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016032,biological_process viral process;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016447,biological_process somatic recombination of immunoglobulin gene segments;GO:0016787,molecular_function hydrolase activity;GO:0016799,molecular_function hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0019899,molecular_function enzyme binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045008,biological_process depyrimidination;GO:0045830,biological_process positive regulation of isotype switching;GO:0097510,biological_process base-excision repair, AP site formation via deaminated base removal	UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]; K03648	uracil DNA glycosylase [Source:HGNC Symbol%3BAcc:HGNC:12572]
ENSG00000122026	812.93	786.03	781.40	767.44	718.13	796.21	0.072866467374759	8.54452781945544	0.237324800700509	0.618417753538588	13:27251308-27256691:+	RPL21	15;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L21e, RPL21; large subunit ribosomal protein L21e; K02889	ribosomal protein L21 [Source:HGNC Symbol%3BAcc:HGNC:10313]
ENSG00000174799	2.67	2.98	2.50	2.50	3.81	3.02	-0.188469513593819	3.35639255747616	0.237327325084241	0.618417753538588	4:55948870-56033363:+	CEP135	13;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007099,biological_process centriole replication;GO:0008022,molecular_function protein C-terminus binding;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010457,biological_process centriole-centriole cohesion;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1902857,biological_process positive regulation of nonmotile primary cilium assembly	NA	centrosomal protein 135 [Source:HGNC Symbol%3BAcc:HGNC:29086]
ENSG00000184481	9.32	9.65	8.11	9.49	11.21	9.33	-0.140299598511888	3.86439714573452	0.237343283481659	0.618417753538588	X:71096196-71103535:+	FOXO4	39;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0007568,biological_process aging;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016579,biological_process protein deubiquitination;GO:0016607,cellular_component nuclear speck;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0031667,biological_process response to nutrient levels;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048863,biological_process stem cell differentiation;GO:0051151,biological_process negative regulation of smooth muscle cell differentiation;GO:0070317,biological_process negative regulation of G0 to G1 transition;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:1990785,biological_process response to water-immersion restraint stress;GO:1990841,molecular_function promoter-specific chromatin binding	FOXO4; forkhead box protein O4; K12358	forkhead box O4 [Source:HGNC Symbol%3BAcc:HGNC:7139]
ENSG00000111799	2.76	3.33	2.35	2.03	3.04	2.48	0.166675216933322	4.64761390744571	0.237629898034054	0.619034611604767	6:75084325-75206051:-	COL12A1	15;GO:0001501,biological_process skeletal system development;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005595,cellular_component collagen type XII trimer;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0030020,molecular_function extracellular matrix structural constituent conferring tensile strength;GO:0030199,biological_process collagen fibril organization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035987,biological_process endodermal cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	COL12A; collagen, type XII, alpha; K08132	collagen type XII alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2188]
ENSG00000141504	133.42	137.59	151.42	138.86	132.40	130.96	0.0831952203519288	6.17147336793211	0.237792123091203	0.619327239599476	17:7626233-7627876:-	SAT2	13;GO:0004145,molecular_function diamine N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0008080,molecular_function N-acetyltransferase activity;GO:0009447,biological_process putrescine catabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0032918,biological_process spermidine acetylation;GO:0032919,biological_process spermine acetylation;GO:0032920,biological_process putrescine acetylation;GO:0042802,molecular_function identical protein binding;GO:0046204,biological_process nor-spermidine metabolic process;GO:0070062,cellular_component extracellular exosome	speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]; K00657	spermidine/spermine N1-acetyltransferase family member 2 [Source:HGNC Symbol%3BAcc:HGNC:23160]
ENSG00000177674	22.61	22.31	25.15	25.50	25.65	25.05	-0.105575407098815	4.35407548346912	0.237912991892639	0.619512055456959	1:11736083-11754802:+	AGTRAP	18;GO:0000139,cellular_component Golgi membrane;GO:0001666,biological_process response to hypoxia;GO:0004945,molecular_function angiotensin type II receptor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0008217,biological_process regulation of blood pressure;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0038166,biological_process angiotensin-activated signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	angiotensin II receptor associated protein [Source:HGNC Symbol%3BAcc:HGNC:13539]
ENSG00000105677	80.28	80.23	79.51	78.88	74.72	75.75	0.0771691388284204	5.72289604379491	0.237978419819138	0.619552459147434	19:35545594-35547526:+	TMEM147	6;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031648,biological_process protein destabilization	NA	transmembrane protein 147 [Source:HGNC Symbol%3BAcc:HGNC:30414]
ENSG00000188342	30.63	31.73	37.74	38.29	32.08	39.72	-0.124774808090928	4.72173814773893	0.238321311011318	0.620306279096891	13:45120514-45284909:+	GTF2F2	26;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000991,molecular_function transcription factor activity, core RNA polymerase II binding;GO:0003677,molecular_function DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005674,cellular_component transcription factor TFIIF complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016070,biological_process RNA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0050434,biological_process positive regulation of viral transcription;GO:0060261,biological_process positive regulation of transcription initiation from RNA polymerase II promoter;GO:0097550,cellular_component transcriptional preinitiation complex	TFIIF2, GTF2F2, TFG2; transcription initiation factor TFIIF subunit beta [EC:3.6.4.12]; K03139	general transcription factor IIF subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:4653]
ENSG00000077097	59.58	63.81	58.00	54.89	60.09	58.38	0.0765136718855992	8.17341479157306	0.238385112301602	0.620306279096891	3:25597904-25664907:-	TOP2B	27;GO:0000166,molecular_function nucleotide binding;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000792,cellular_component heterochromatin;GO:0000819,biological_process sister chromatid segregation;GO:0001764,biological_process neuron migration;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003916,molecular_function DNA topoisomerase activity;GO:0003918,molecular_function DNA topoisomerase type II (ATP-hydrolyzing) activity;GO:0005080,molecular_function protein kinase C binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006259,biological_process DNA metabolic process;GO:0006265,biological_process DNA topological change;GO:0007409,biological_process axonogenesis;GO:0008022,molecular_function protein C-terminus binding;GO:0016853,molecular_function isomerase activity;GO:0016925,biological_process protein sumoylation;GO:0019899,molecular_function enzyme binding;GO:0030900,biological_process forebrain development;GO:0042826,molecular_function histone deacetylase binding;GO:0044774,biological_process mitotic DNA integrity checkpoint;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	TOP2; DNA topoisomerase II [EC:5.6.2.2]; K03164	topoisomerase (DNA) II beta [Source:HGNC Symbol%3BAcc:HGNC:11990]
ENSG00000095319	13.51	13.68	13.80	14.61	14.34	14.53	-0.0733170746563167	6.21103555189407	0.238417889113934	0.620306279096891	9:128947698-129007096:+	NUP188	23;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0006110,biological_process regulation of glycolytic process;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0043657,cellular_component host cell;GO:0044611,cellular_component nuclear pore inner ring;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:0090521,biological_process glomerular visceral epithelial cell migration;GO:1900034,biological_process regulation of cellular response to heat	NUP188; nuclear pore complex protein Nup188; K14311	nucleoporin 188 [Source:HGNC Symbol%3BAcc:HGNC:17859]
ENSG00000144395	1.50	1.61	1.76	1.28	1.45	1.57	0.190254364164612	2.52733328827766	0.238551803484566	0.620524630480702	2:196639553-196763490:+	CCDC150	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 150 [Source:HGNC Symbol%3BAcc:HGNC:26834]
ENSG00000136986	134.50	132.75	139.19	150.34	133.86	149.04	-0.0800799796631606	6.72293774196978	0.238685996838814	0.62074361591456	8:123013163-123042423:-	DERL1	40;GO:0002020,molecular_function protease binding;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005785,cellular_component signal recognition particle receptor complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0006986,biological_process response to unfolded protein;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031648,biological_process protein destabilization;GO:0032092,biological_process positive regulation of protein binding;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0034620,biological_process cellular response to unfolded protein;GO:0036502,cellular_component Derlin-1-VIMP complex;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042288,molecular_function MHC class I protein binding;GO:0043657,cellular_component host cell;GO:0045184,biological_process establishment of protein localization;GO:0048500,cellular_component signal recognition particle;GO:0051117,molecular_function ATPase binding;GO:0051260,biological_process protein homooligomerization;GO:0055085,biological_process transmembrane transport;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:1990381,molecular_function ubiquitin-specific protease binding	DERL1; Derlin-1; K11519	derlin 1 [Source:HGNC Symbol%3BAcc:HGNC:28454]
ENSG00000162889	91.12	100.68	93.13	87.56	90.57	93.76	0.0775397146759438	6.86117724891439	0.23900649853319	0.621446934707267	1:206684943-206734283:+	MAPKAPK2	45;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006691,biological_process leukotriene metabolic process;GO:0006950,biological_process response to stress;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007265,biological_process Ras protein signal transduction;GO:0009931,molecular_function calcium-dependent protein serine/threonine kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0032496,biological_process response to lipopolysaccharide;GO:0032675,biological_process regulation of interleukin-6 production;GO:0032680,biological_process regulation of tumor necrosis factor production;GO:0034097,biological_process response to cytokine;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0038066,biological_process p38MAPK cascade;GO:0042535,biological_process positive regulation of tumor necrosis factor biosynthetic process;GO:0043488,biological_process regulation of mRNA stability;GO:0044351,biological_process macropinocytosis;GO:0046777,biological_process protein autophosphorylation;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048255,biological_process mRNA stabilization;GO:0048839,biological_process inner ear development;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0070062,cellular_component extracellular exosome;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:1900034,biological_process regulation of cellular response to heat	MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]; K04443	mitogen-activated protein kinase-activated protein kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6887]
ENSG00000089060	7.87	7.40	6.83	7.19	6.36	6.86	0.12653373995035	3.75567799987167	0.239164395198268	0.621604859487138	12:113298758-113359493:-	SLC8B1	31;GO:0005432,molecular_function calcium:sodium antiporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006816,biological_process calcium ion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0015297,molecular_function antiporter activity;GO:0015368,molecular_function calcium:cation antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030061,cellular_component mitochondrial crista;GO:0032592,cellular_component integral component of mitochondrial membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042383,cellular_component sarcolemma;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0050796,biological_process regulation of insulin secretion;GO:0050896,biological_process response to stimulus;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086036,biological_process regulation of cardiac muscle cell membrane potential;GO:0086038,molecular_function calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential;GO:0099093,biological_process mitochondrial calcium release;GO:1901623,biological_process regulation of lymphocyte chemotaxis;GO:2001256,biological_process regulation of store-operated calcium entry	NA	solute carrier family 8 member B1 [Source:HGNC Symbol%3BAcc:HGNC:26175]
ENSG00000116396	1.33	1.71	1.21	1.27	0.97	1.29	0.254627988745836	1.56283722173393	0.239167389745474	0.621604859487138	1:110211342-110283100:+	KCNC4	19;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031594,cellular_component neuromuscular junction;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0043679,cellular_component axon terminus;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0051260,biological_process protein homooligomerization;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport	NA	potassium voltage-gated channel subfamily C member 4 [Source:HGNC Symbol%3BAcc:HGNC:6236]
ENSG00000168071	1.70	1.37	1.40	1.51	0.98	1.41	0.212457777335773	2.80730979681911	0.239360910043683	0.621782569625382	11:64340222-64357534:+	CCDC88B	14;GO:0001819,biological_process positive regulation of cytokine production;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042832,biological_process defense response to protozoan;GO:0050870,biological_process positive regulation of T cell activation;GO:0051959,molecular_function dynein light intermediate chain binding	NA	coiled-coil domain containing 88B [Source:HGNC Symbol%3BAcc:HGNC:26757]
ENSG00000134001	87.02	85.52	89.74	96.04	87.28	96.06	-0.0789701187817935	6.51167083568196	0.23938358455202	0.621782569625382	14:67359996-67386516:+	EIF2S1	36;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005844,cellular_component polysome;GO:0005850,cellular_component eukaryotic translation initiation factor 2 complex;GO:0005851,cellular_component eukaryotic translation initiation factor 2B complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0007568,biological_process aging;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0032057,biological_process negative regulation of translational initiation in response to stress;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034605,biological_process cellular response to heat;GO:0034644,biological_process cellular response to UV;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0043022,molecular_function ribosome binding;GO:0043558,biological_process regulation of translational initiation in response to stress;GO:0043614,cellular_component multi-eIF complex;GO:0044207,cellular_component translation initiation ternary complex;GO:0046777,biological_process protein autophosphorylation;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0097451,cellular_component glial limiting end-foot;GO:1901216,biological_process positive regulation of neuron death;GO:1905098,biological_process negative regulation of guanyl-nucleotide exchange factor activity;GO:1990737,biological_process response to manganese-induced endoplasmic reticulum stress;GO:2000676,biological_process positive regulation of type B pancreatic cell apoptotic process	EIF2S1; translation initiation factor 2 subunit 1; K03237	eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:3265]
ENSG00000091482	13.64	7.60	15.05	7.37	13.79	7.99	0.351892689817376	1.6148092452667	0.239435138226518	0.621782569625382	X:21705971-21758163:-	SMPX	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005927,cellular_component muscle tendon junction;GO:0006941,biological_process striated muscle contraction;GO:0031430,cellular_component M band;GO:0043034,cellular_component costamere;GO:0043292,cellular_component contractile fiber	NA	small muscle protein%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:11122]
ENSG00000151532	5.85	5.73	4.84	7.38	6.72	5.32	-0.229419700363109	2.11535916755676	0.239461064172068	0.621782569625382	10:112446997-112818744:+	VTI1A	35;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005776,cellular_component autophagosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006623,biological_process protein targeting to vacuole;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0006896,biological_process Golgi to vacuole transport;GO:0006914,biological_process autophagy;GO:0008021,cellular_component synaptic vesicle;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044306,cellular_component neuron projection terminus;GO:0048280,biological_process vesicle fusion with Golgi apparatus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050882,biological_process voluntary musculoskeletal movement;GO:0090161,biological_process Golgi ribbon formation	VTI1; vesicle transport through interaction with t-SNAREs 1; K08493	vesicle transport through interaction with t-SNAREs 1A [Source:HGNC Symbol%3BAcc:HGNC:17792]
ENSG00000171303	4.48	3.96	5.92	7.03	3.72	6.78	-0.270768669809565	2.69975213144598	0.23953741244086	0.621782569625382	2:26692689-26733420:+	KCNK3	28;GO:0005216,molecular_function ion channel activity;GO:0005252,molecular_function open rectifier potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007420,biological_process brain development;GO:0008022,molecular_function protein C-terminus binding;GO:0008083,molecular_function growth factor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022841,molecular_function potassium ion leak channel activity;GO:0030322,biological_process stabilization of membrane potential;GO:0034220,biological_process ion transmembrane transport;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0044548,molecular_function S100 protein binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051481,biological_process negative regulation of cytosolic calcium ion concentration;GO:0061337,biological_process cardiac conduction;GO:0071294,biological_process cellular response to zinc ion;GO:0071456,biological_process cellular response to hypoxia;GO:0071805,biological_process potassium ion transmembrane transport;GO:0090102,biological_process cochlea development	KCNK3, K2P3.1; potassium channel subfamily K member 3; K04914	potassium two pore domain channel subfamily K member 3 [Source:HGNC Symbol%3BAcc:HGNC:6278]
ENSG00000168491	1.30	1.42	1.49	1.60	1.59	1.70	-0.208141298043334	2.12311259572648	0.239639898265087	0.621782569625382	4:185445181-185471759:-	CCDC110	2;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	coiled-coil domain containing 110 [Source:HGNC Symbol%3BAcc:HGNC:28504]
ENSG00000178409	0.85	1.04	0.80	0.75	0.76	0.65	0.308312066109314	1.09929788942611	0.239640312973711	0.621782569625382	6:107065181-107115269:-	BEND3	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000182,molecular_function rDNA binding;GO:0000183,biological_process chromatin silencing at rDNA;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005720,cellular_component nuclear heterochromatin;GO:0005730,cellular_component nucleolus;GO:0006306,biological_process DNA methylation;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0034773,biological_process histone H4-K20 trimethylation;GO:0036124,biological_process histone H3-K9 trimethylation;GO:0043967,biological_process histone H4 acetylation;GO:0080182,biological_process histone H3-K4 trimethylation;GO:0098532,biological_process histone H3-K27 trimethylation	NA	BEN domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:23040]
ENSG00000134717	102.63	93.77	112.09	116.96	109.31	105.30	-0.0887448406196337	5.97469688264142	0.239683051097234	0.621782569625382	1:52056124-52090716:+	BTF3L4	1;GO:0005515,molecular_function protein binding	EGD1, BTF3; nascent polypeptide-associated complex subunit beta; K01527	basic transcription factor 3 like 4 [Source:HGNC Symbol%3BAcc:HGNC:30547]
ENSG00000196458	3.40	3.08	3.25	3.53	3.76	3.73	-0.162638559512132	2.83814490146227	0.239692534560349	0.621782569625382	12:132918307-132956306:-	ZNF605	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 605 [Source:HGNC Symbol%3BAcc:HGNC:28068]
ENSG00000152082	129.35	119.55	120.31	131.05	124.91	137.26	-0.0783906942544207	6.69453672727355	0.239736677533802	0.621782569625382	2:130181736-130190729:+	MZT2B	9;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008274,cellular_component gamma-tubulin ring complex	NA	mitotic spindle organizing protein 2B [Source:HGNC Symbol%3BAcc:HGNC:25886]
ENSG00000196247	3.04	4.56	3.31	3.93	4.63	3.91	-0.195175495024864	3.32840140798637	0.239841557752735	0.621924640982807	7:64666082-64711582:+	ZNF107	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 107 [Source:HGNC Symbol%3BAcc:HGNC:12887]
ENSG00000196422	13.59	12.28	13.56	14.31	13.34	14.54	-0.0825941174106822	5.63187765525284	0.240011212992821	0.622234583725957	9:135479078-135488893:+	PPP1R26	6;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019902,molecular_function phosphatase binding	NA	protein phosphatase 1 regulatory subunit 26 [Source:HGNC Symbol%3BAcc:HGNC:29089]
ENSG00000101365	51.35	52.60	50.55	54.85	55.79	53.37	-0.0752724314971449	6.10152728869608	0.240070579989946	0.622258531930508	20:2658394-2664219:-	IDH3B	15;GO:0000287,molecular_function magnesium ion binding;GO:0004449,molecular_function isocitrate dehydrogenase (NAD+) activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006102,biological_process isocitrate metabolic process;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006734,biological_process NADH metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0046872,molecular_function metal ion binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process	IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]; K00030	isocitrate dehydrogenase 3 (NAD(+)) beta [Source:HGNC Symbol%3BAcc:HGNC:5385]
ENSG00000169446	21.03	23.10	26.22	18.86	22.77	21.65	0.163833322475204	3.15335227442616	0.240252498656084	0.622506030946616	X:135962069-135974063:-	MMGT1	17;GO:0000139,cellular_component Golgi membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022890,molecular_function inorganic cation transmembrane transporter activity;GO:0031901,cellular_component early endosome membrane;GO:0072546,cellular_component ER membrane protein complex;GO:0098655,biological_process cation transmembrane transport;GO:1903830,biological_process magnesium ion transmembrane transport	NA	membrane magnesium transporter 1 [Source:HGNC Symbol%3BAcc:HGNC:28100]
ENSG00000143252	185.75	188.72	164.26	164.87	180.87	165.82	0.0855013158469574	6.88230839046997	0.240266365444714	0.622506030946616	1:161314256-161375340:+	SDHC	16;GO:0000104,molecular_function succinate dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005749,cellular_component mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0006099,biological_process tricarboxylic acid cycle;GO:0006121,biological_process mitochondrial electron transport, succinate to ubiquinone;GO:0009055,molecular_function electron carrier activity;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0020037,molecular_function heme binding;GO:0045273,cellular_component respiratory chain complex II;GO:0045281,cellular_component succinate dehydrogenase complex;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	SDHC, SDH3; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit; K00236	succinate dehydrogenase complex subunit C [Source:HGNC Symbol%3BAcc:HGNC:10682]
ENSG00000104055	0.49	0.48	0.61	0.55	0.70	0.84	-0.386701596151605	0.579219110565248	0.240387564494854	0.62269007472342	15:43232594-43266857:-	TGM5	10;GO:0003810,molecular_function protein-glutamine gamma-glutamyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0008544,biological_process epidermis development;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018149,biological_process peptide cross-linking;GO:0046872,molecular_function metal ion binding;GO:0070268,biological_process cornification	NA	transglutaminase 5 [Source:HGNC Symbol%3BAcc:HGNC:11781]
ENSG00000108819	33.37	31.82	30.03	34.49	32.92	33.88	-0.0775358029305388	6.3307880182758	0.240594839349623	0.623096962413284	17:50133734-50150630:-	PPP1R9B	66;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001975,biological_process response to amphetamine;GO:0003006,biological_process developmental process involved in reproduction;GO:0003779,molecular_function actin binding;GO:0004672,molecular_function protein kinase activity;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007015,biological_process actin filament organization;GO:0007568,biological_process aging;GO:0007612,biological_process learning;GO:0008022,molecular_function protein C-terminus binding;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0010243,biological_process response to organonitrogen compound;GO:0014069,cellular_component postsynaptic density;GO:0014070,biological_process response to organic cyclic compound;GO:0015629,cellular_component actin cytoskeleton;GO:0016358,biological_process dendrite development;GO:0019722,biological_process calcium-mediated signaling;GO:0019900,molecular_function kinase binding;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0030042,biological_process actin filament depolymerization;GO:0030175,cellular_component filopodium;GO:0030426,cellular_component growth cone;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031749,molecular_function D2 dopamine receptor binding;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0032591,cellular_component dendritic spine membrane;GO:0034695,biological_process response to prostaglandin E;GO:0035094,biological_process response to nicotine;GO:0035690,biological_process cellular response to drug;GO:0035902,biological_process response to immobilization stress;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043200,biological_process response to amino acid;GO:0044325,molecular_function ion channel binding;GO:0044326,cellular_component dendritic spine neck;GO:0044327,cellular_component dendritic spine head;GO:0048545,biological_process response to steroid hormone;GO:0050804,biological_process modulation of synaptic transmission;GO:0051015,molecular_function actin filament binding;GO:0060179,biological_process male mating behavior;GO:0061458,biological_process reproductive system development;GO:0071315,biological_process cellular response to morphine;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071482,biological_process cellular response to light stimulus;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0097338,biological_process response to clozapine;GO:1901653,biological_process cellular response to peptide;GO:1903119,biological_process protein localization to actin cytoskeleton;GO:1903829,biological_process positive regulation of cellular protein localization;GO:1904372,biological_process positive regulation of protein localization to actin cortical patch;GO:1904373,biological_process response to kainic acid;GO:1904386,biological_process response to L-phenylalanine derivative;GO:1990778,biological_process protein localization to cell periphery;GO:1990780,cellular_component cytoplasmic side of dendritic spine plasma membrane;GO:2000474,biological_process regulation of opioid receptor signaling pathway	NA	protein phosphatase 1 regulatory subunit 9B [Source:HGNC Symbol%3BAcc:HGNC:9298]
ENSG00000182993	2.40	3.77	3.20	2.75	2.79	2.01	0.306157584725701	1.13362067936647	0.240667814377592	0.623155940731967	12:14803571-14906586:+	C12orf60	NA	NA	chromosome 12 open reading frame 60 [Source:HGNC Symbol%3BAcc:HGNC:28726]
ENSG00000165322	13.47	14.27	13.72	13.33	12.64	13.35	0.0844877662241689	5.10059066844164	0.240758893750586	0.623261761861527	10:31805403-31928876:-	ARHGAP12	7;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 12 [Source:HGNC Symbol%3BAcc:HGNC:16348]
ENSG00000174292	2.31	1.80	2.00	2.11	1.69	1.46	0.241055627469062	1.99626016258759	0.240822447174673	0.623279255432928	17:7380533-7389774:+	TNK1	25;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0045087,biological_process innate immune response;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046777,biological_process protein autophosphorylation	NA	tyrosine kinase non receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:11940]
ENSG00000109771	1.52	1.43	1.38	0.98	1.21	1.18	0.370094893928752	0.604311016043197	0.240871766895709	0.623279255432928	4:185363878-185395899:-	LRP2BP	2;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm	NA	LRP2 binding protein [Source:HGNC Symbol%3BAcc:HGNC:25434]
ENSG00000197279	2.28	1.90	2.63	2.88	3.18	2.17	-0.242164240239846	1.93487358883987	0.240956020923486	0.623279255432928	6:28080974-28089563:+	ZNF165	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 165 [Source:HGNC Symbol%3BAcc:HGNC:12953]
ENSG00000173227	32.10	25.65	33.74	35.04	29.18	36.36	-0.120083937717918	5.3486450990546	0.241132898967828	0.623279255432928	11:67006777-67050863:+	SYT12	17;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0006906,biological_process vesicle fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030276,molecular_function clathrin binding;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045202,cellular_component synapse;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0048792,biological_process spontaneous exocytosis of neurotransmitter;GO:0060291,biological_process long-term synaptic potentiation	NA	synaptotagmin 12 [Source:HGNC Symbol%3BAcc:HGNC:18381]
ENSG00000198270	10.36	7.70	8.33	9.16	10.10	10.57	-0.153957982368081	3.40124665117119	0.241204481581458	0.623279255432928	12:111931281-112013185:-	TMEM116	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 116 [Source:HGNC Symbol%3BAcc:HGNC:25084]
ENSG00000164305	16.66	22.66	19.13	20.27	23.55	20.99	-0.147567888592378	4.10154652997949	0.241221323270314	0.623279255432928	4:184627695-184649509:-	CASP3	78;GO:0001666,biological_process response to hypoxia;GO:0001782,biological_process B cell homeostasis;GO:0002020,molecular_function protease binding;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007507,biological_process heart development;GO:0007605,biological_process sensory perception of sound;GO:0007611,biological_process learning or memory;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008627,biological_process intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0009411,biological_process response to UV;GO:0009611,biological_process response to wounding;GO:0009749,biological_process response to glucose;GO:0010033,biological_process response to organic substance;GO:0010038,biological_process response to metal ion;GO:0010165,biological_process response to X-ray;GO:0014070,biological_process response to organic cyclic compound;GO:0016005,molecular_function phospholipase A2 activator activity;GO:0016241,biological_process regulation of macroautophagy;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0021766,biological_process hippocampus development;GO:0030182,biological_process neuron differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030220,biological_process platelet formation;GO:0030889,biological_process negative regulation of B cell proliferation;GO:0031264,cellular_component death-inducing signaling complex;GO:0032025,biological_process response to cobalt ion;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0034349,biological_process glial cell apoptotic process;GO:0034612,biological_process response to tumor necrosis factor;GO:0035094,biological_process response to nicotine;GO:0035329,biological_process hippo signaling;GO:0035556,biological_process intracellular signal transduction;GO:0042060,biological_process wound healing;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0043029,biological_process T cell homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043200,biological_process response to amino acid;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045121,cellular_component membrane raft;GO:0045165,biological_process cell fate commitment;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786,biological_process negative regulation of cell cycle;GO:0046007,biological_process negative regulation of activated T cell proliferation;GO:0046677,biological_process response to antibiotic;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0051384,biological_process response to glucocorticoid;GO:0051402,biological_process neuron apoptotic process;GO:0071310,biological_process cellular response to organic substance;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0072734,biological_process cellular response to staurosporine;GO:0097153,molecular_function cysteine-type endopeptidase activity involved in apoptotic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097194,biological_process execution phase of apoptosis;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis	CASP3; caspase 3 [EC:3.4.22.56]; K02187	caspase 3 [Source:HGNC Symbol%3BAcc:HGNC:1504]
ENSG00000100297	26.45	27.36	25.35	32.13	23.75	30.30	-0.112365272754337	5.99179569448456	0.241239449120993	0.623279255432928	22:35400062-35425430:+	MCM5	20;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003682,molecular_function chromatin binding;GO:0003688,molecular_function DNA replication origin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0042555,cellular_component MCM complex;GO:0051301,biological_process cell division	MCM5, CDC46; DNA replication licensing factor MCM5 [EC:3.6.4.12]; K02209	minichromosome maintenance complex component 5 [Source:HGNC Symbol%3BAcc:HGNC:6948]
ENSG00000138592	24.45	22.77	22.87	22.08	22.39	22.66	0.0750477992947669	6.26516631596549	0.241276791556542	0.623279255432928	15:50424379-50514419:+	USP8	31;GO:0000281,biological_process mitotic cytokinesis;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007032,biological_process endosome organization;GO:0007049,biological_process cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008283,biological_process cell proliferation;GO:0010008,cellular_component endosome membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0030496,cellular_component midbody;GO:0031313,cellular_component extrinsic component of endosome membrane;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043197,cellular_component dendritic spine;GO:0045296,molecular_function cadherin binding;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination	USP8, UBP5; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]; K11839	ubiquitin specific peptidase 8 [Source:HGNC Symbol%3BAcc:HGNC:12631]
ENSG00000080200	7.86	7.51	8.44	7.32	7.62	7.79	0.0806262565523308	6.11798458774267	0.241291195635217	0.623279255432928	3:97822039-97944963:+	CRYBG3	1;GO:0030246,molecular_function carbohydrate binding	NA	crystallin beta-gamma domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:34427]
ENSG00000156642	59.51	70.59	67.25	59.01	65.87	61.90	0.0888106982603601	6.25833309236044	0.24134129077919	0.623279255432928	15:73560013-73634134:-	NPTN	30;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005104,molecular_function fibroblast growth factor receptor binding;GO:0005105,molecular_function type 1 fibroblast growth factor receptor binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007399,biological_process nervous system development;GO:0008542,biological_process visual learning;GO:0009986,cellular_component cell surface;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0042734,cellular_component presynaptic membrane;GO:0044325,molecular_function ion channel binding;GO:0045743,biological_process positive regulation of fibroblast growth factor receptor signaling pathway;GO:0048170,biological_process positive regulation of long-term neuronal synaptic plasticity;GO:0050804,biological_process modulation of synaptic transmission;GO:0050808,biological_process synapse organization;GO:0050839,molecular_function cell adhesion molecule binding;GO:0060077,cellular_component inhibitory synapse;GO:0060291,biological_process long-term synaptic potentiation;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0097060,cellular_component synaptic membrane;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1902683,biological_process regulation of receptor localization to synapse;GO:1903829,biological_process positive regulation of cellular protein localization;GO:1904861,biological_process excitatory synapse assembly	NA	neuroplastin [Source:HGNC Symbol%3BAcc:HGNC:17867]
ENSG00000113734	8.32	9.26	9.36	8.82	10.18	11.41	-0.168763726866891	3.062918555036	0.241386557538422	0.623279255432928	5:173144441-173164387:+	BNIP1	21;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0007029,biological_process endoplasmic reticulum organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016320,biological_process endoplasmic reticulum membrane fusion;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0031201,cellular_component SNARE complex;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0097194,biological_process execution phase of apoptosis	SEC20; protein transport protein SEC20; K08497	BCL2 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1082]
ENSG00000173334	16.14	14.47	14.05	15.83	16.92	16.00	-0.111211868078016	4.13459334605218	0.241413164296588	0.623279255432928	8:125430320-125438405:+	TRIB1	23;GO:0004672,molecular_function protein kinase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007254,biological_process JNK cascade;GO:0008134,molecular_function transcription factor binding;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031665,biological_process negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032496,biological_process response to lipopolysaccharide;GO:0043405,biological_process regulation of MAP kinase activity;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045645,biological_process positive regulation of eosinophil differentiation;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045659,biological_process negative regulation of neutrophil differentiation;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0055106,molecular_function ubiquitin-protein transferase regulator activity	NA	tribbles pseudokinase 1 [Source:HGNC Symbol%3BAcc:HGNC:16891]
ENSG00000152778	16.26	14.34	13.74	13.88	12.38	14.93	0.119710076305934	4.37821035440535	0.24141840490788	0.623279255432928	10:89414585-89421001:+	IFIT5	20;GO:0000049,molecular_function tRNA binding;GO:0000339,molecular_function RNA cap binding;GO:0002376,biological_process immune system process;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0008266,molecular_function poly(U) RNA binding;GO:0008385,cellular_component IkappaB kinase complex;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045177,cellular_component apical part of cell;GO:0051607,biological_process defense response to virus	NA	interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol%3BAcc:HGNC:13328]
ENSG00000162994	6.95	6.36	6.49	5.62	6.26	6.32	0.13657218545169	3.49784770990429	0.241477279630902	0.623301616148551	2:55174790-55232563:-	CLHC1	1;GO:0005515,molecular_function protein binding	NA	clathrin heavy chain linker domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26453]
ENSG00000054793	5.53	4.84	5.25	5.46	5.94	5.69	-0.110765711445846	4.11489769975815	0.241671197292764	0.62345612536926	20:51596513-51768634:-	ATP9A	20;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005524,molecular_function ATP binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006897,biological_process endocytosis;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031901,cellular_component early endosome membrane;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome	NA	ATPase phospholipid transporting 9A (putative) [Source:HGNC Symbol%3BAcc:HGNC:13540]
ENSG00000205269	3.92	2.41	3.35	2.08	3.06	2.31	0.417366577968282	0.36926262601458	0.241848493297164	0.62345612536926	6:11538277-11583524:+	TMEM170B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 170B [Source:HGNC Symbol%3BAcc:HGNC:34244]
ENSG00000167646	2.38	3.67	2.32	3.23	2.95	3.58	-0.236495178518143	2.5509544606557	0.241887483464753	0.62345612536926	19:55158660-55166722:-	DNAAF3	4;GO:0005737,cellular_component cytoplasm;GO:0030030,biological_process cell projection organization;GO:0044458,biological_process motile cilium assembly;GO:0070286,biological_process axonemal dynein complex assembly	NA	dynein axonemal assembly factor 3 [Source:HGNC Symbol%3BAcc:HGNC:30492]
ENSG00000253910	0.63	0.61	0.68	0.77	0.70	0.93	-0.308222430939642	1.13111156910307	0.241891307797237	0.62345612536926	5:141360041-141512979:+	PCDHGB2	9;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protocadherin gamma subfamily B%2C 2 [Source:HGNC Symbol%3BAcc:HGNC:8709]
ENSG00000180104	34.68	36.66	37.18	35.11	35.69	32.76	0.0789159085179616	6.37661766766433	0.241922223100307	0.62345612536926	5:443157-471937:+	EXOC3	16;GO:0000145,cellular_component exocyst;GO:0000149,molecular_function SNARE binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0015031,biological_process protein transport;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0030667,cellular_component secretory granule membrane;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051601,biological_process exocyst localization	NA	exocyst complex component 3 [Source:HGNC Symbol%3BAcc:HGNC:30378]
ENSG00000156304	17.04	17.55	18.76	17.62	17.02	16.21	0.081685237156442	5.90520415983351	0.241929347149543	0.62345612536926	21:31671032-31732075:-	SCAF4	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm	NA	SR-related CTD associated factor 4 [Source:HGNC Symbol%3BAcc:HGNC:19304]
ENSG00000104946	28.63	29.70	30.47	29.52	28.16	27.09	0.0786794478631941	5.91634213152737	0.242039380011671	0.62345612536926	19:49877424-49888749:+	TBC1D17	16;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006914,biological_process autophagy;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 17 [Source:HGNC Symbol%3BAcc:HGNC:25699]
ENSG00000100226	27.97	24.89	28.53	29.59	28.94	28.39	-0.0794321374307952	6.13302557856443	0.242066600955497	0.62345612536926	22:38705722-38738299:+	GTPBP1	12;GO:0000166,molecular_function nucleotide binding;GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0046039,biological_process GTP metabolic process;GO:0061014,biological_process positive regulation of mRNA catabolic process	NA	GTP binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4669]
ENSG00000110060	8.08	6.95	6.78	6.23	7.36	6.19	0.159477576664809	3.3447930802092	0.242097361948223	0.62345612536926	11:125893484-125903221:-	PUS3	12;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity;GO:0031119,biological_process tRNA pseudouridine synthesis;GO:1990481,biological_process mRNA pseudouridine synthesis	NA	pseudouridylate synthase 3 [Source:HGNC Symbol%3BAcc:HGNC:25461]
ENSG00000110888	13.66	12.39	13.36	12.77	11.98	12.79	0.0852569676229911	5.48275040210443	0.24209862774179	0.62345612536926	12:30709551-30754951:-	CAPRIN2	22;GO:0003723,molecular_function RNA binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0032092,biological_process positive regulation of protein binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0040008,biological_process regulation of growth;GO:0043235,cellular_component receptor complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	caprin family member 2 [Source:HGNC Symbol%3BAcc:HGNC:21259]
ENSG00000159479	37.34	33.93	30.45	38.60	35.40	36.17	-0.102491787254123	5.00538337670355	0.242122558622235	0.62345612536926	1:43383916-43389808:-	MED8	10;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex	NA	mediator complex subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:19971]
ENSG00000005175	31.22	32.77	30.99	33.44	32.28	35.25	-0.0787580937766514	6.0297918337997	0.242139851800951	0.62345612536926	12:47661248-47706061:-	RPAP3	2;GO:0005515,molecular_function protein binding;GO:0097255,cellular_component R2TP complex	NA	RNA polymerase II associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:26151]
ENSG00000042317	6.64	6.89	6.22	7.04	6.77	7.89	-0.12993485249233	3.87158199016676	0.242592178200379	0.624491229365678	14:88384923-88470350:+	SPATA7	16;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005930,cellular_component axoneme;GO:0007601,biological_process visual perception;GO:0015630,cellular_component microtubule cytoskeleton;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045494,biological_process photoreceptor cell maintenance;GO:0050896,biological_process response to stimulus;GO:1903546,biological_process protein localization to photoreceptor outer segment;GO:1903621,biological_process protein localization to photoreceptor connecting cilium	NA	spermatogenesis associated 7 [Source:HGNC Symbol%3BAcc:HGNC:20423]
ENSG00000078401	16.43	13.07	18.98	14.24	13.95	15.48	0.173972042350357	3.31865481870217	0.242717005947037	0.624576802191429	6:12290362-12297194:+	EDN1	116;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001501,biological_process skeletal system development;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0001569,biological_process patterning of blood vessels;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001821,biological_process histamine secretion;GO:0003100,biological_process regulation of systemic arterial blood pressure by endothelin;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005179,molecular_function hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006885,biological_process regulation of pH;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007507,biological_process heart development;GO:0007585,biological_process respiratory gaseous exchange;GO:0007589,biological_process body fluid secretion;GO:0008217,biological_process regulation of blood pressure;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010193,biological_process response to ozone;GO:0010259,biological_process multicellular organism aging;GO:0010460,biological_process positive regulation of heart rate;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0010870,biological_process positive regulation of receptor biosynthetic process;GO:0014032,biological_process neural crest cell development;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014823,biological_process response to activity;GO:0014824,biological_process artery smooth muscle contraction;GO:0014826,biological_process vein smooth muscle contraction;GO:0015758,biological_process glucose transport;GO:0016049,biological_process cell growth;GO:0019229,biological_process regulation of vasoconstriction;GO:0019233,biological_process sensory perception of pain;GO:0019722,biological_process calcium-mediated signaling;GO:0030072,biological_process peptide hormone secretion;GO:0030133,cellular_component transport vesicle;GO:0030185,biological_process nitric oxide transport;GO:0030195,biological_process negative regulation of blood coagulation;GO:0030335,biological_process positive regulation of cell migration;GO:0030818,biological_process negative regulation of cAMP biosynthetic process;GO:0031583,biological_process phospholipase D-activating G-protein coupled receptor signaling pathway;GO:0031707,molecular_function endothelin A receptor binding;GO:0031708,molecular_function endothelin B receptor binding;GO:0032269,biological_process negative regulation of cellular protein metabolic process;GO:0032308,biological_process positive regulation of prostaglandin secretion;GO:0032496,biological_process response to lipopolysaccharide;GO:0033093,cellular_component Weibel-Palade body;GO:0033574,biological_process response to testosterone;GO:0034392,biological_process negative regulation of smooth muscle cell apoptotic process;GO:0034696,biological_process response to prostaglandin F;GO:0035094,biological_process response to nicotine;GO:0035556,biological_process intracellular signal transduction;GO:0035690,biological_process cellular response to drug;GO:0035810,biological_process positive regulation of urine volume;GO:0035815,biological_process positive regulation of renal sodium excretion;GO:0035994,biological_process response to muscle stretch;GO:0042045,biological_process epithelial fluid transport;GO:0042310,biological_process vasoconstriction;GO:0042313,biological_process protein kinase C deactivation;GO:0042474,biological_process middle ear morphogenesis;GO:0042482,biological_process positive regulation of odontogenesis;GO:0042493,biological_process response to drug;GO:0042554,biological_process superoxide anion generation;GO:0043179,biological_process rhythmic excitation;GO:0043200,biological_process response to amino acid;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0044321,biological_process response to leptin;GO:0045178,cellular_component basal part of cell;GO:0045321,biological_process leukocyte activation;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045793,biological_process positive regulation of cell size;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046887,biological_process positive regulation of hormone secretion;GO:0046888,biological_process negative regulation of hormone secretion;GO:0048016,biological_process inositol phosphate-mediated signaling;GO:0048237,cellular_component rough endoplasmic reticulum lumen;GO:0048514,biological_process blood vessel morphogenesis;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050880,biological_process regulation of blood vessel size;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051216,biological_process cartilage development;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051771,biological_process negative regulation of nitric-oxide synthase biosynthetic process;GO:0051899,biological_process membrane depolarization;GO:0051930,biological_process regulation of sensory perception of pain;GO:0060137,biological_process maternal process involved in parturition;GO:0060298,biological_process positive regulation of sarcomere organization;GO:0060585,biological_process positive regulation of prostaglandin-endoperoxide synthase activity;GO:0061051,biological_process positive regulation of cell growth involved in cardiac muscle cell development;GO:0070101,biological_process positive regulation of chemokine-mediated signaling pathway;GO:0071277,biological_process cellular response to calcium ion;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0071389,biological_process cellular response to mineralocorticoid stimulus;GO:0071398,biological_process cellular response to fatty acid;GO:0071456,biological_process cellular response to hypoxia;GO:0071548,biological_process response to dexamethasone;GO:0071559,biological_process response to transforming growth factor beta;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:1902074,biological_process response to salt	EDN1; endothelin-1; K16366	endothelin 1 [Source:HGNC Symbol%3BAcc:HGNC:3176]
ENSG00000173575	24.09	22.18	25.37	23.31	21.49	23.48	0.0822938602248619	7.1239323633432	0.242735654508021	0.624576802191429	15:92900188-93028005:+	CHD2	23;GO:0000166,molecular_function nucleotide binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007517,biological_process muscle organ development;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0042393,molecular_function histone binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0060218,biological_process hematopoietic stem cell differentiation;GO:0070062,cellular_component extracellular exosome	NA	chromodomain helicase DNA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1917]
ENSG00000170385	6.04	6.85	7.55	7.38	7.93	7.49	-0.147989474109102	3.47528636710705	0.242776369175352	0.624576802191429	1:211571567-211578742:-	SLC30A1	30;GO:0001701,biological_process in utero embryonic development;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006829,biological_process zinc II ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0010043,biological_process response to zinc ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0030315,cellular_component T-tubule;GO:0031965,cellular_component nuclear membrane;GO:0046929,biological_process negative regulation of neurotransmitter secretion;GO:0055085,biological_process transmembrane transport;GO:0061088,biological_process regulation of sequestering of zinc ion;GO:0065009,biological_process regulation of molecular function;GO:0070509,biological_process calcium ion import;GO:0070574,biological_process cadmium ion transmembrane transport;GO:0071577,biological_process zinc II ion transmembrane transport;GO:0071584,biological_process negative regulation of zinc ion transmembrane import;GO:0071585,biological_process detoxification of cadmium ion;GO:0090281,biological_process negative regulation of calcium ion import	SLC30A1, ZNT1; solute carrier family 30 (zinc transporter), member 1; K14688	solute carrier family 30 member 1 [Source:HGNC Symbol%3BAcc:HGNC:11012]
ENSG00000213694	1.25	1.60	1.69	1.25	0.87	1.43	0.347160511123029	0.742024902415664	0.242881903426289	0.624595483859755	9:88991446-89005010:+	S1PR3	22;GO:0001816,biological_process cytokine production;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007219,biological_process Notch signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032651,biological_process regulation of interleukin-1 beta production;GO:0038036,molecular_function sphingosine-1-phosphate receptor activity;GO:1903141,biological_process negative regulation of establishment of endothelial barrier	S1PR3, EDG3; sphingosine 1-phosphate receptor 3; K04290	sphingosine-1-phosphate receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:3167]
ENSG00000083799	7.63	7.16	8.03	7.44	6.68	7.32	0.1061549199942	4.47443187417251	0.242884266542418	0.624595483859755	16:50742049-50801935:+	CYLD	59;GO:0002376,biological_process immune system process;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0030496,cellular_component midbody;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0036064,cellular_component ciliary basal body;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0042995,cellular_component cell projection;GO:0043369,biological_process CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0043393,biological_process regulation of protein binding;GO:0045087,biological_process innate immune response;GO:0045577,biological_process regulation of B cell differentiation;GO:0045581,biological_process negative regulation of T cell differentiation;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048872,biological_process homeostasis of number of cells;GO:0050862,biological_process positive regulation of T cell receptor signaling pathway;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070064,molecular_function proline-rich region binding;GO:0070266,biological_process necroptotic process;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097542,cellular_component ciliary tip;GO:1901026,biological_process ripoptosome assembly involved in necroptotic process;GO:1902017,biological_process regulation of cilium assembly;GO:1903829,biological_process positive regulation of cellular protein localization;GO:1990108,biological_process protein linear deubiquitination;GO:1990380,molecular_function Lys48-specific deubiquitinase activity;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001242,biological_process regulation of intrinsic apoptotic signaling pathway	CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]; K08601	CYLD lysine 63 deubiquitinase [Source:HGNC Symbol%3BAcc:HGNC:2584]
ENSG00000198157	16.70	20.22	14.88	21.06	21.16	16.04	-0.165090986628554	3.96437598197967	0.243130123598299	0.625098223741856	X:81113700-81201942:-	HMGN5	18;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006749,biological_process glutathione metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016569,biological_process covalent chromatin modification;GO:0031492,molecular_function nucleosomal DNA binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0071157,biological_process negative regulation of cell cycle arrest	NA	high mobility group nucleosome binding domain 5 [Source:HGNC Symbol%3BAcc:HGNC:8013]
ENSG00000050748	20.37	20.16	22.25	21.46	22.15	23.81	-0.0896746279844559	5.1741526756522	0.243223287688429	0.625159065154449	5:180233142-180292099:-	MAPK9	40;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004705,molecular_function JUN kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007254,biological_process JNK cascade;GO:0007258,biological_process JUN phosphorylation;GO:0008134,molecular_function transcription factor binding;GO:0009612,biological_process response to mechanical stimulus;GO:0010628,biological_process positive regulation of gene expression;GO:0010744,biological_process positive regulation of macrophage derived foam cell differentiation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042752,biological_process regulation of circadian rhythm;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046686,biological_process response to cadmium ion;GO:0048511,biological_process rhythmic process;GO:0048666,biological_process neuron development;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0061833,biological_process protein localization to tricellular tight junction;GO:0071276,biological_process cellular response to cadmium ion;GO:0071310,biological_process cellular response to organic substance;GO:0071803,biological_process positive regulation of podosome assembly;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]; K04440	mitogen-activated protein kinase 9 [Source:HGNC Symbol%3BAcc:HGNC:6886]
ENSG00000142507	106.18	111.13	105.56	115.51	117.42	110.01	-0.0764167839672497	6.3569229776242	0.243254514194473	0.625159065154449	17:4796143-4798503:+	PSMB6	40;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045296,molecular_function cadherin binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMB6; 20S proteasome subunit beta 1 [EC:3.4.25.1]; K02738	proteasome subunit beta 6 [Source:HGNC Symbol%3BAcc:HGNC:9543]
ENSG00000102144	638.51	717.31	616.28	598.02	679.49	589.36	0.0906883614105352	9.64590358275954	0.243359041237832	0.625298236159225	X:78065187-78129296:+	PGK1	21;GO:0000166,molecular_function nucleotide binding;GO:0004618,molecular_function phosphoglycerate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016740,molecular_function transferase activity;GO:0030855,biological_process epithelial cell differentiation;GO:0031639,biological_process plasminogen activation;GO:0045121,cellular_component membrane raft;GO:0047134,molecular_function protein-disulfide reductase activity;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia	PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]; K00927	phosphoglycerate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:8896]
ENSG00000196154	6.29	5.68	5.83	8.65	6.51	6.96	-0.294096102412565	1.12304442405393	0.243414327952755	0.625310855314061	1:153543612-153550136:-	S100A4	16;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding;GO:0046914,molecular_function transition metal ion binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050786,molecular_function RAGE receptor binding;GO:0070062,cellular_component extracellular exosome	NA	S100 calcium binding protein A4 [Source:HGNC Symbol%3BAcc:HGNC:10494]
ENSG00000144452	4.06	3.68	4.22	3.93	4.38	4.62	-0.0977657811108244	5.04976529515585	0.243475005159784	0.62533731410064	2:214931541-215138428:-	ABCA12	35;GO:0000166,molecular_function nucleotide binding;GO:0005102,molecular_function receptor binding;GO:0005215,molecular_function transporter activity;GO:0005319,molecular_function lipid transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0019725,biological_process cellular homeostasis;GO:0030216,biological_process keratinocyte differentiation;GO:0031424,biological_process keratinization;GO:0032940,biological_process secretion by cell;GO:0033700,biological_process phospholipid efflux;GO:0034040,molecular_function lipid-transporting ATPase activity;GO:0034191,molecular_function apolipoprotein A-I receptor binding;GO:0035627,biological_process ceramide transport;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043129,biological_process surfactant homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045055,biological_process regulated exocytosis;GO:0048286,biological_process lung alveolus development;GO:0055085,biological_process transmembrane transport;GO:0055088,biological_process lipid homeostasis;GO:0061436,biological_process establishment of skin barrier;GO:0072659,biological_process protein localization to plasma membrane;GO:0097209,cellular_component epidermal lamellar body;GO:2000010,biological_process positive regulation of protein localization to cell surface	ABCA12; ATP-binding cassette, subfamily A (ABC1), member 12; K05646	ATP binding cassette subfamily A member 12 [Source:HGNC Symbol%3BAcc:HGNC:14637]
ENSG00000120860	27.28	31.11	33.40	27.68	26.99	30.55	0.115433198446403	4.42819578853899	0.243603503823042	0.625429950275226	12:102012926-102062149:-	WASHC3	7;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0015031,biological_process protein transport;GO:0071203,cellular_component WASH complex	NA	WASH complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:24256]
ENSG00000122786	68.56	67.97	69.88	63.48	64.89	69.55	0.0724665107501062	7.43850684418888	0.243611843195095	0.625429950275226	7:134744251-134970728:+	CALD1	17;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005523,molecular_function tropomyosin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0006936,biological_process muscle contraction;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0017022,molecular_function myosin binding;GO:0030016,cellular_component myofibril;GO:0030478,cellular_component actin cap;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding	CALD1; caldesmon; K12327	caldesmon 1 [Source:HGNC Symbol%3BAcc:HGNC:1441]
ENSG00000096384	769.44	800.74	730.08	821.32	792.23	821.09	-0.0701677970778021	10.7441258779147	0.243714966915363	0.625487580552551	6:44246165-44253888:+	HSP90AB1	93;GO:0000166,molecular_function nucleotide binding;GO:0001890,biological_process placenta development;GO:0002134,molecular_function UTP binding;GO:0002135,molecular_function CTP binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006805,biological_process xenobiotic metabolic process;GO:0006950,biological_process response to stress;GO:0006986,biological_process response to unfolded protein;GO:0007004,biological_process telomere maintenance via telomerase;GO:0008144,molecular_function drug binding;GO:0008180,cellular_component COP9 signalosome;GO:0009651,biological_process response to salt stress;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017098,molecular_function sulfonylurea receptor binding;GO:0019062,biological_process virion attachment to host cell;GO:0019887,molecular_function protein kinase regulator activity;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030235,molecular_function nitric-oxide synthase regulator activity;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030911,molecular_function TPR domain binding;GO:0031072,molecular_function heat shock protein binding;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031526,cellular_component brush border membrane;GO:0032092,biological_process positive regulation of protein binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0032564,molecular_function dATP binding;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0034751,cellular_component aryl hydrocarbon receptor complex;GO:0034774,cellular_component secretory granule lumen;GO:0035690,biological_process cellular response to drug;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042220,biological_process response to cocaine;GO:0042277,molecular_function peptide binding;GO:0042470,cellular_component melanosome;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043008,molecular_function ATP-dependent protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044325,molecular_function ion channel binding;GO:0045296,molecular_function cadherin binding;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045793,biological_process positive regulation of cell size;GO:0046983,molecular_function protein dimerization activity;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070182,molecular_function DNA polymerase binding;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071353,biological_process cellular response to interleukin-4;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0097435,biological_process fibril organization;GO:0097718,molecular_function disordered domain specific binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1901389,biological_process negative regulation of transforming growth factor beta activation;GO:1903660,biological_process negative regulation of complement-dependent cytotoxicity;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1905323,biological_process telomerase holoenzyme complex assembly;GO:1990226,molecular_function histone methyltransferase binding;GO:1990913,cellular_component sperm head plasma membrane;GO:1990917,cellular_component ooplasm;GO:2000010,biological_process positive regulation of protein localization to cell surface	HSP90A, htpG; molecular chaperone HtpG; K04079	heat shock protein 90 alpha family class B member 1 [Source:HGNC Symbol%3BAcc:HGNC:5258]
ENSG00000113391	4.33	4.32	4.46	3.56	3.95	4.15	0.179458033970378	2.46895513370751	0.24374860562685	0.625487580552551	5:93618068-94111699:-	FAM172A	2;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum	NA	family with sequence similarity 172 member A [Source:HGNC Symbol%3BAcc:HGNC:25365]
ENSG00000073737	1.12	0.92	1.42	0.86	1.00	0.80	0.412691784833102	0.397555002046088	0.24378545997851	0.625487580552551	2:169064788-169096167:+	DHRS9	18;GO:0002138,biological_process retinoic acid biosynthetic process;GO:0004022,molecular_function alcohol dehydrogenase (NAD) activity;GO:0004745,molecular_function retinol dehydrogenase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008209,biological_process androgen metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016854,molecular_function racemase and epimerase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030855,biological_process epithelial cell differentiation;GO:0031090,cellular_component organelle membrane;GO:0042448,biological_process progesterone metabolic process;GO:0042572,biological_process retinol metabolic process;GO:0042904,biological_process 9-cis-retinoic acid biosynthetic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0047035,molecular_function testosterone dehydrogenase (NAD+) activity;GO:0055114,biological_process oxidation-reduction process	DHRS9; dehydrogenase/reductase SDR family member 9 [EC:1.1.-.-]; K11149	dehydrogenase/reductase 9 [Source:HGNC Symbol%3BAcc:HGNC:16888]
ENSG00000112592	18.76	18.78	20.51	21.62	20.01	21.21	-0.101225491805175	4.46157607293303	0.243909826959338	0.625677346982076	6:170554301-170572870:+	TBP	45;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001034,molecular_function RNA polymerase III transcription factor activity, sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001093,molecular_function TFIIB-class transcription factor binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001129,molecular_function RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly;GO:0001939,cellular_component female pronucleus;GO:0001940,cellular_component male pronucleus;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005672,cellular_component transcription factor TFIIA complex;GO:0005719,cellular_component nuclear euchromatin;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0007283,biological_process spermatogenesis;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0019899,molecular_function enzyme binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043234,cellular_component protein complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045120,cellular_component pronucleus;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:0070491,molecular_function repressing transcription factor binding;GO:0097550,cellular_component transcriptional preinitiation complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein; K03120	TATA-box binding protein [Source:HGNC Symbol%3BAcc:HGNC:11588]
ENSG00000204580	20.46	18.53	20.55	18.26	19.24	19.38	0.0814499579441386	5.85199443237352	0.244143949445686	0.626148521584567	6:30876420-30900156:+	DDR1	43;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007565,biological_process female pregnancy;GO:0007566,biological_process embryo implantation;GO:0007595,biological_process lactation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010715,biological_process regulation of extracellular matrix disassembly;GO:0014909,biological_process smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030198,biological_process extracellular matrix organization;GO:0038062,molecular_function protein tyrosine kinase collagen receptor activity;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0043235,cellular_component receptor complex;GO:0043583,biological_process ear development;GO:0044319,biological_process wound healing, spreading of cells;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0060749,biological_process mammary gland alveolus development;GO:0061302,biological_process smooth muscle cell-matrix adhesion;GO:0061564,biological_process axon development;GO:0070062,cellular_component extracellular exosome;GO:1990138,biological_process neuron projection extension	NA	discoidin domain receptor tyrosine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:2730]
ENSG00000214300	2.14	2.38	1.88	2.18	2.90	2.48	-0.237881839844355	1.99220340486469	0.244195826172162	0.626152197949813	7:100307701-100322196:+	SPDYE3	2;GO:0019901,molecular_function protein kinase binding;GO:0045859,biological_process regulation of protein kinase activity	NA	speedy/RINGO cell cycle regulator family member E3 [Source:HGNC Symbol%3BAcc:HGNC:35462]
ENSG00000065675	4.71	6.38	6.71	6.33	6.70	6.87	-0.156453054832985	3.75630435045377	0.244658082238335	0.627045985004399	10:6427142-6580301:-	PRKCQ	47;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0001772,cellular_component immunological synapse;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0006954,biological_process inflammatory response;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016235,cellular_component aggresome;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030168,biological_process platelet activation;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032740,biological_process positive regulation of interleukin-17 production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0035556,biological_process intracellular signal transduction;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0045086,biological_process positive regulation of interleukin-2 biosynthetic process;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050870,biological_process positive regulation of T cell activation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060326,biological_process cell chemotaxis;GO:0070233,biological_process negative regulation of T cell apoptotic process;GO:0090330,biological_process regulation of platelet aggregation;GO:0097194,biological_process execution phase of apoptosis;GO:1904355,biological_process positive regulation of telomere capping;GO:2000318,biological_process positive regulation of T-helper 17 type immune response;GO:2000570,biological_process positive regulation of T-helper 2 cell activation	PRKCD; novel protein kinase C delta type [EC:2.7.11.13]; K06068	protein kinase C theta [Source:HGNC Symbol%3BAcc:HGNC:9410]
ENSG00000145687	7.74	6.09	8.82	6.68	6.51	7.17	0.178341838324463	3.11075794971534	0.24471417110402	0.627045985004399	5:81413020-81751797:-	SSBP2	9;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	single stranded DNA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15831]
ENSG00000162194	10.81	9.75	9.36	8.97	8.78	9.74	0.135062033964668	3.58256379545783	0.244731462717979	0.627045985004399	11:62662816-62672255:-	LBHD1	NA	NA	LBH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28351]
ENSG00000170959	0.16	0.33	0.37	0.22	0.22	0.21	0.383393385098502	0.581047784956016	0.244776071392042	0.627045985004399	11:30830368-31369810:-	DCDC1	2;GO:0005622,cellular_component intracellular;GO:0035556,biological_process intracellular signal transduction	NA	doublecortin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20625]
ENSG00000104219	28.87	26.73	27.94	28.15	24.80	25.99	0.0963268450851555	4.90689060770433	0.244840138358307	0.627045985004399	8:17156028-17224799:+	ZDHHC2	13;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0044267,biological_process cellular protein metabolic process;GO:0055038,cellular_component recycling endosome membrane	NA	zinc finger DHHC-type containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18469]
ENSG00000083635	6.18	7.40	5.45	6.15	4.75	6.01	0.169127736873548	3.16964936498202	0.244847489673433	0.627045985004399	13:44939248-44989483:-	NUFIP1	23;GO:0000492,biological_process box C/D snoRNP assembly;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005726,cellular_component perichromatin fibrils;GO:0005730,cellular_component nucleolus;GO:0006396,biological_process RNA processing;GO:0008023,cellular_component transcription elongation factor complex;GO:0016363,cellular_component nuclear matrix;GO:0022626,cellular_component cytosolic ribosome;GO:0030515,molecular_function snoRNA binding;GO:0030674,molecular_function protein binding, bridging;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048786,cellular_component presynaptic active zone;GO:0051117,molecular_function ATPase binding;GO:0051259,biological_process protein oligomerization;GO:0070761,cellular_component pre-snoRNP complex	NA	NUFIP1%2C FMR1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8057]
ENSG00000205309	4.22	5.59	5.15	6.00	4.73	6.89	-0.239572978133936	2.14427423827481	0.245055164905066	0.627338627134939	17:17303334-17347663:+	NT5M	14;GO:0000166,molecular_function nucleotide binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006260,biological_process DNA replication;GO:0008252,molecular_function nucleotidase activity;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0009117,biological_process nucleotide metabolic process;GO:0009223,biological_process pyrimidine deoxyribonucleotide catabolic process;GO:0009264,biological_process deoxyribonucleotide catabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0046079,biological_process dUMP catabolic process;GO:0046135,biological_process pyrimidine nucleoside catabolic process;GO:0046872,molecular_function metal ion binding	E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]; K01081	5'%2C3'-nucleotidase%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:15769]
ENSG00000111786	175.04	181.73	163.66	182.44	179.04	191.88	-0.0781866809777993	6.91034525263865	0.245083582300521	0.627338627134939	12:120461667-120469793:-	SRSF9	18;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0009636,biological_process response to toxic substance;GO:0019904,molecular_function protein domain specific binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0043279,biological_process response to alkaloid;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome	SFRS1, ASF, SF2; splicing factor, arginine/serine-rich 1; K12890	serine and arginine rich splicing factor 9 [Source:HGNC Symbol%3BAcc:HGNC:10791]
ENSG00000174628	18.60	22.57	19.16	20.25	22.65	22.85	-0.121899188345118	4.38844818915203	0.245113376428297	0.627338627134939	16:19716455-19858467:+	IQCK	NA	NA	IQ motif containing K [Source:HGNC Symbol%3BAcc:HGNC:28556]
ENSG00000242252	3.77	2.87	4.42	3.49	1.77	2.81	0.478392317577216	0.156393356478287	0.24519441569711	0.627339001144403	1:156241961-156243321:+	BGLAP	50;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001649,biological_process osteoblast differentiation;GO:0002076,biological_process osteoblast development;GO:0005198,molecular_function structural molecule activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0006465,biological_process signal peptide processing;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007155,biological_process cell adhesion;GO:0007568,biological_process aging;GO:0007569,biological_process cell aging;GO:0008147,molecular_function structural constituent of bone;GO:0009612,biological_process response to mechanical stimulus;GO:0009629,biological_process response to gravity;GO:0010035,biological_process response to inorganic substance;GO:0010043,biological_process response to zinc ion;GO:0014070,biological_process response to organic cyclic compound;GO:0014823,biological_process response to activity;GO:0017187,biological_process peptidyl-glutamic acid carboxylation;GO:0030282,biological_process bone mineralization;GO:0030425,cellular_component dendrite;GO:0030500,biological_process regulation of bone mineralization;GO:0031214,biological_process biomineral tissue development;GO:0031667,biological_process response to nutrient levels;GO:0031982,cellular_component vesicle;GO:0032571,biological_process response to vitamin K;GO:0033280,biological_process response to vitamin D;GO:0033574,biological_process response to testosterone;GO:0033594,biological_process response to hydroxyisoflavone;GO:0042476,biological_process odontogenesis;GO:0042493,biological_process response to drug;GO:0042995,cellular_component cell projection;GO:0043204,cellular_component perikaryon;GO:0043627,biological_process response to estrogen;GO:0045124,biological_process regulation of bone resorption;GO:0045471,biological_process response to ethanol;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0046848,molecular_function hydroxyapatite binding;GO:0046872,molecular_function metal ion binding;GO:0051384,biological_process response to glucocorticoid;GO:0060348,biological_process bone development;GO:0071305,biological_process cellular response to vitamin D;GO:0071363,biological_process cellular response to growth factor stimulus	NA	bone gamma-carboxyglutamate protein [Source:HGNC Symbol%3BAcc:HGNC:1043]
ENSG00000137944	22.66	23.72	22.80	21.77	21.33	22.46	0.0863089970747155	4.94141519364375	0.245214600302316	0.627339001144403	1:88935772-88992953:-	KYAT3	17;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006520,biological_process cellular amino acid metabolic process;GO:0008483,molecular_function transaminase activity;GO:0009058,biological_process biosynthetic process;GO:0016212,molecular_function kynurenine-oxoglutarate transaminase activity;GO:0016740,molecular_function transferase activity;GO:0016829,molecular_function lyase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0036137,molecular_function kynurenine aminotransferase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0047315,molecular_function kynurenine-glyoxylate transaminase activity;GO:0047804,molecular_function cysteine-S-conjugate beta-lyase activity;GO:0070189,biological_process kynurenine metabolic process;GO:0097052,biological_process L-kynurenine metabolic process	CCBL; kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]; K00816	kynurenine aminotransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:33238]
ENSG00000108654	247.60	244.57	241.94	227.07	240.22	239.24	0.0670512904511882	8.83044208259343	0.245415507239339	0.627723612479273	17:64499615-64508199:-	DDX5	63;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0003676,molecular_function nucleic acid binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0009299,biological_process mRNA transcription;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0030331,molecular_function estrogen receptor binding;GO:0030509,biological_process BMP signaling pathway;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0035500,molecular_function MH2 domain binding;GO:0036002,molecular_function pre-mRNA binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045069,biological_process regulation of viral genome replication;GO:0045445,biological_process myoblast differentiation;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048511,biological_process rhythmic process;GO:0050681,molecular_function androgen receptor binding;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0061614,biological_process pri-miRNA transcription from RNA polymerase II promoter;GO:0070062,cellular_component extracellular exosome;GO:0070412,molecular_function R-SMAD binding;GO:0070878,molecular_function primary miRNA binding;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071141,cellular_component SMAD protein complex;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:1903800,biological_process positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1990841,molecular_function promoter-specific chromatin binding;GO:2001014,biological_process regulation of skeletal muscle cell differentiation	NA	DEAD-box helicase 5 [Source:HGNC Symbol%3BAcc:HGNC:2746]
ENSG00000242515	1.31	0.95	0.91	0.83	0.70	0.96	0.363489839894379	0.752136439274856	0.245572277302192	0.627812770725472	2:233636453-233773305:+	UGT1A10	17;GO:0005080,molecular_function protein kinase C binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008152,biological_process metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046982,molecular_function protein heterodimerization activity;GO:0051552,biological_process flavone metabolic process;GO:0052695,biological_process cellular glucuronidation;GO:0052696,biological_process flavonoid glucuronidation;GO:0052697,biological_process xenobiotic glucuronidation	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 1 member A10 [Source:HGNC Symbol%3BAcc:HGNC:12531]
ENSG00000254470	3.94	3.92	4.30	3.50	4.09	3.52	0.146241896949792	3.37383457499703	0.24559506186515	0.627812770725472	11:65775892-65780802:-	AP5B1	6;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016197,biological_process endosomal transport;GO:0030119,cellular_component AP-type membrane coat adaptor complex	NA	adaptor related protein complex 5 beta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:25104]
ENSG00000135269	52.73	51.57	54.48	55.63	52.35	61.64	-0.0832436994971583	6.26543508707515	0.245602095757906	0.627812770725472	7:116210492-116258783:+	TES	14;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0030054,cellular_component cell junction;GO:0042127,biological_process regulation of cell proliferation;GO:0043234,cellular_component protein complex;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding	NA	testin LIM domain protein [Source:HGNC Symbol%3BAcc:HGNC:14620]
ENSG00000217930	3.91	3.53	4.89	4.14	3.64	2.51	0.287140319062475	1.68617598554161	0.245705203626419	0.627947023391958	16:4331548-4355607:-	PAM16	14;GO:0001405,cellular_component presequence translocase-associated import motor;GO:0001503,biological_process ossification;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0005759,cellular_component mitochondrial matrix;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031314,cellular_component extrinsic component of mitochondrial inner membrane;GO:0032780,biological_process negative regulation of ATPase activity;GO:0043234,cellular_component protein complex	NA	presequence translocase associated motor 16 homolog [Source:HGNC Symbol%3BAcc:HGNC:29679]
ENSG00000130956	54.84	51.22	47.64	49.01	51.23	45.74	0.0867938534151395	5.955525096221	0.245812545600454	0.628092039633273	9:96450200-96491336:+	HABP4	12;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030017,cellular_component sarcomere;GO:0043392,biological_process negative regulation of DNA binding;GO:0071260,biological_process cellular response to mechanical stimulus	NA	hyaluronan binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:17062]
ENSG00000146409	12.65	10.55	13.13	13.52	13.97	12.54	-0.117638540519823	4.14030547784238	0.245901276742517	0.628189452192811	6:132769369-132798553:-	SLC18B1	6;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 18 member B1 [Source:HGNC Symbol%3BAcc:HGNC:21573]
ENSG00000152409	1.43	1.74	2.04	2.05	1.59	2.54	-0.238326159902991	2.53517661804957	0.246079370756326	0.628448320346872	5:79236188-79327215:+	JMY	20;GO:0003713,molecular_function transcription coactivator activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0031252,cellular_component cell leading edge;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0070060,biological_process 'de novo' actin filament nucleation;GO:0070358,biological_process actin polymerization-dependent cell motility;GO:0071933,molecular_function Arp2/3 complex binding;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	junction mediating and regulatory protein%2C p53 cofactor [Source:HGNC Symbol%3BAcc:HGNC:28916]
ENSG00000173715	17.49	16.66	15.53	18.12	16.64	18.57	-0.0913070739607992	5.1990123200355	0.246103865721916	0.628448320346872	11:66744450-66843328:+	C11orf80	4;GO:0005694,cellular_component chromosome;GO:0007131,biological_process reciprocal meiotic recombination;GO:0042138,biological_process meiotic DNA double-strand break formation;GO:0051321,biological_process meiotic cell cycle	NA	chromosome 11 open reading frame 80 [Source:HGNC Symbol%3BAcc:HGNC:26197]
ENSG00000121957	30.98	32.85	30.93	33.19	33.87	33.43	-0.075350308187385	6.11057830703448	0.246280982174422	0.628771252927006	1:108875349-108934545:+	GPSM2	32;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000166,molecular_function nucleotide binding;GO:0000922,cellular_component spindle pole;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008022,molecular_function protein C-terminus binding;GO:0019904,molecular_function protein domain specific binding;GO:0030695,molecular_function GTPase regulator activity;GO:0031291,biological_process Ran protein signal transduction;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0043621,molecular_function protein self-association;GO:0045177,cellular_component apical part of cell;GO:0050790,biological_process regulation of catalytic activity;GO:0051301,biological_process cell division;GO:0051661,biological_process maintenance of centrosome location;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0060487,biological_process lung epithelial cell differentiation;GO:0070840,molecular_function dynein complex binding;GO:0097431,cellular_component mitotic spindle pole;GO:0099738,cellular_component cell cortex region;GO:1904778,biological_process positive regulation of protein localization to cell cortex;GO:1905832,biological_process positive regulation of spindle assembly	NA	G protein signaling modulator 2 [Source:HGNC Symbol%3BAcc:HGNC:29501]
ENSG00000132694	8.70	8.73	8.80	8.95	9.91	9.15	-0.0829008950230247	5.41067186917763	0.246705162589297	0.629724693238937	1:156934839-157045370:-	ARHGEF11	22;GO:0000910,biological_process cytokinesis;GO:0001558,biological_process regulation of cell growth;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006928,biological_process movement of cell or subcellular component;GO:0006941,biological_process striated muscle contraction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007266,biological_process Rho protein signal transduction;GO:0016020,cellular_component membrane;GO:0030010,biological_process establishment of cell polarity;GO:0030036,biological_process actin cytoskeleton organization;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	ARHGEF11; Rho guanine nucleotide exchange factor 11; K12331	Rho guanine nucleotide exchange factor 11 [Source:HGNC Symbol%3BAcc:HGNC:14580]
ENSG00000187961	6.14	5.20	6.43	4.75	5.30	6.11	0.155180654635406	3.52642507421822	0.246858073074829	0.629985456636072	1:960586-965715:+	KLHL17	19;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007420,biological_process brain development;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0031208,molecular_function POZ domain binding;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032839,cellular_component dendrite cytoplasm;GO:0032947,molecular_function protein complex scaffold;GO:0043025,cellular_component neuronal cell body;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0051015,molecular_function actin filament binding	NA	kelch like family member 17 [Source:HGNC Symbol%3BAcc:HGNC:24023]
ENSG00000176209	27.62	22.55	30.76	29.78	26.42	35.24	-0.156617942294347	3.70375019738475	0.246991868470143	0.630197340867396	8:42541154-42555193:+	SMIM19	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 19 [Source:HGNC Symbol%3BAcc:HGNC:25166]
ENSG00000157873	1.53	3.16	2.85	2.65	1.21	1.92	0.370834617882328	1.04774009064275	0.247210629254865	0.63039624267974	1:2555638-2565382:+	TNFRSF14	27;GO:0001618,molecular_function virus receptor activity;GO:0002741,biological_process positive regulation of cytokine secretion involved in immune response;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0031295,biological_process T cell costimulation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0046642,biological_process negative regulation of alpha-beta T cell proliferation;GO:0046718,biological_process viral entry into host cell;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0097190,biological_process apoptotic signaling pathway;GO:2000406,biological_process positive regulation of T cell migration	TNFRSF14, HVEM, CD270; tumor necrosis factor receptor superfamily member 14; K05152	TNF receptor superfamily member 14 [Source:HGNC Symbol%3BAcc:HGNC:11912]
ENSG00000012232	8.37	7.95	6.64	6.78	7.41	7.12	0.11807215845817	4.3912882744306	0.247214234532383	0.63039624267974	8:28600468-28755599:+	EXTL3	12;GO:0001888,molecular_function glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0004872,molecular_function receptor activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030307,biological_process positive regulation of cell growth;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0046872,molecular_function metal ion binding	EXTL3; alpha-1,4-N-acetylglucosaminyltransferase EXTL3 [EC:2.4.1.223 2.4.1.224]; K02370	exostosin like glycosyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:3518]
ENSG00000144741	22.37	21.83	25.36	26.44	24.02	24.97	-0.101750103265312	4.66605990957658	0.247232006818269	0.63039624267974	3:66133609-66388116:+	SLC25A26	10;GO:0000095,molecular_function S-adenosyl-L-methionine transmembrane transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006839,biological_process mitochondrial transport;GO:0015805,biological_process S-adenosyl-L-methionine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1901962,biological_process S-adenosyl-L-methionine transmembrane transport	NA	solute carrier family 25 member 26 [Source:HGNC Symbol%3BAcc:HGNC:20661]
ENSG00000138640	18.36	13.77	17.72	16.42	13.30	16.47	0.125180958362499	5.69990494223486	0.247272964280001	0.63039624267974	4:88725954-89111398:-	FAM13A	5;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	family with sequence similarity 13 member A [Source:HGNC Symbol%3BAcc:HGNC:19367]
ENSG00000140471	6.08	5.80	5.31	5.53	5.28	5.04	0.129538178163466	3.7220300928724	0.247435431559929	0.63064070487784	15:100559368-100603230:-	LINS1	1;GO:0050890,biological_process cognition	NA	lines homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:30922]
ENSG00000135090	9.52	9.36	10.05	8.75	7.74	10.36	0.11849435093396	4.6574749646558	0.247470464308383	0.63064070487784	12:118149800-118372945:-	TAOK3	27;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0042981,biological_process regulation of apoptotic process;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation	TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]; K04429	TAO kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:18133]
ENSG00000197172	1.05	1.01	0.47	1.51	1.13	0.90	-0.474673413760982	0.140319725000032	0.24763257147146	0.630898271877078	X:152766135-152769747:-	MAGEA6	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	MAGE family member A6 [Source:HGNC Symbol%3BAcc:HGNC:6804]
ENSG00000108599	13.96	12.37	14.22	14.10	15.18	14.52	-0.0927455007178468	4.85275201109646	0.247673187694917	0.630898271877078	17:19904301-19978343:-	AKAP10	10;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0008104,biological_process protein localization;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation	NA	A-kinase anchoring protein 10 [Source:HGNC Symbol%3BAcc:HGNC:368]
ENSG00000160539	2.69	2.58	2.71	2.76	4.09	3.02	-0.288761961941488	1.36938005492444	0.247724511241984	0.630899540017797	9:131289693-131309262:+	PLPP7	7;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	phospholipid phosphatase 7 (inactive) [Source:HGNC Symbol%3BAcc:HGNC:28174]
ENSG00000146833	28.96	25.56	30.68	28.97	24.46	26.85	0.101563167852689	5.47143958031643	0.2480768870713	0.631624499925	7:99876957-99919600:-	TRIM4	13;GO:0002376,biological_process immune system process;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006914,biological_process autophagy;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0070206,biological_process protein trimerization	NA	tripartite motif containing 4 [Source:HGNC Symbol%3BAcc:HGNC:16275]
ENSG00000160072	7.56	8.01	7.34	7.36	6.52	7.31	0.119780766160908	3.84974555961757	0.24811093705263	0.631624499925	1:1471768-1497848:+	ATAD3B	9;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	ATPase family%2C AAA domain containing 3B [Source:HGNC Symbol%3BAcc:HGNC:24007]
ENSG00000048471	12.01	11.24	10.91	10.98	10.95	10.40	0.0931065751058624	4.86271490398281	0.248216475561674	0.631763606960643	16:11976736-12574289:+	SNX29	2;GO:0035091,molecular_function phosphatidylinositol binding;GO:0070062,cellular_component extracellular exosome	NA	sorting nexin 29 [Source:HGNC Symbol%3BAcc:HGNC:30542]
ENSG00000168067	5.20	4.31	4.64	4.44	4.81	3.54	0.165337591030522	3.48685742700599	0.2482745539469	0.631781885638146	11:64784913-64803241:-	MAP4K2	32;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005623,cellular_component cell;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006903,biological_process vesicle targeting;GO:0006955,biological_process immune response;GO:0007254,biological_process JNK cascade;GO:0007257,biological_process activation of JUN kinase activity;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016740,molecular_function transferase activity;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0045087,biological_process innate immune response;GO:0046330,biological_process positive regulation of JNK cascade	MAP4K2, GCK; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]; K04414	mitogen-activated protein kinase kinase kinase kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6864]
ENSG00000172775	76.49	85.28	77.23	82.35	86.27	85.55	-0.0807673803678957	5.98910442884644	0.248425439096354	0.631922812335219	16:57152465-57186116:-	FAM192A	2;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	family with sequence similarity 192 member A [Source:HGNC Symbol%3BAcc:HGNC:29856]
ENSG00000109046	94.11	91.13	98.08	84.07	90.56	95.92	0.0789894294524121	6.94826767727589	0.248431750922087	0.631922812335219	17:27294075-27315926:+	WSB1	9;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	WD repeat and SOCS box containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19221]
ENSG00000131791	10.56	9.95	11.09	13.58	10.22	11.89	-0.159790774497566	3.2232818701267	0.248545862815812	0.632028070850716	1:147155105-147172550:-	PRKAB2	18;GO:0004679,molecular_function AMP-activated protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006853,biological_process carnitine shuttle;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0045859,biological_process regulation of protein kinase activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit; K07199	protein kinase AMP-activated non-catalytic subunit beta 2 [Source:HGNC Symbol%3BAcc:HGNC:9379]
ENSG00000105793	21.50	20.88	18.68	18.82	18.09	20.33	0.10222593357584	4.6264117342605	0.248574965108611	0.632028070850716	7:90335222-90391455:+	GTPBP10	9;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0042254,biological_process ribosome biogenesis	NA	GTP binding protein 10 [Source:HGNC Symbol%3BAcc:HGNC:25106]
ENSG00000267534	1.60	1.90	1.60	1.20	1.15	1.66	0.33596786321438	0.806231711115607	0.248670589924379	0.632141722861216	19:10221434-10231272:-	S1PR2	20;GO:0000187,biological_process activation of MAPK activity;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0038036,molecular_function sphingosine-1-phosphate receptor activity;GO:0046847,biological_process filopodium assembly;GO:0090394,biological_process negative regulation of excitatory postsynaptic potential;GO:1903142,biological_process positive regulation of establishment of endothelial barrier	S1PR2, EDG5; sphingosine 1-phosphate receptor 2; K04292	sphingosine-1-phosphate receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:3169]
ENSG00000272647	1.49	1.01	4.09	2.77	0.60	0.93	0.654418481846872	-0.237030859593499	0.248996156972199	0.632839741297277	7:99558694-99607810:+	AC005020.2	NA	NA	NA
ENSG00000175220	35.98	39.40	39.68	37.01	37.83	34.49	0.0841310481730778	5.62612196882319	0.249111616276438	0.633003580929258	11:46677079-46700615:-	ARHGAP1	24;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017124,molecular_function SH3 domain binding;GO:0017137,molecular_function Rab GTPase binding;GO:0032439,biological_process endosome localization;GO:0033572,biological_process transferrin transport;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome;GO:0097443,cellular_component sorting endosome;GO:0098706,biological_process ferric iron import across plasma membrane;GO:2001136,biological_process negative regulation of endocytic recycling	NA	Rho GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:673]
ENSG00000203879	79.19	77.37	86.17	79.75	74.11	78.07	0.0783382857915746	6.92620819355932	0.2491698236124	0.633021903499944	X:154436912-154443467:+	GDI1	26;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005093,molecular_function Rab GDP-dissociation inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016491,molecular_function oxidoreductase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030496,cellular_component midbody;GO:0032482,biological_process Rab protein signal transduction;GO:0043005,cellular_component neuron projection;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050790,biological_process regulation of catalytic activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051592,biological_process response to calcium ion;GO:0055114,biological_process oxidation-reduction process;GO:0061024,biological_process membrane organization;GO:0090315,biological_process negative regulation of protein targeting to membrane	NA	GDP dissociation inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:4226]
ENSG00000122870	62.33	69.09	61.01	56.41	66.38	59.71	0.0874576640670702	7.56575901107422	0.24932644327801	0.633219754001095	10:58513139-58831437:+	BICC1	7;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	BicC family RNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19351]
ENSG00000122417	20.74	20.01	22.64	20.39	19.07	20.78	0.0871127638040644	5.48196445140946	0.249349726702437	0.633219754001095	1:86346823-86396342:-	ODF2L	1;GO:0005813,cellular_component centrosome	NA	outer dense fiber of sperm tails 2 like [Source:HGNC Symbol%3BAcc:HGNC:29225]
ENSG00000087008	10.86	11.01	12.23	13.58	11.05	12.52	-0.110867527619684	4.6520321961666	0.24949187566945	0.633425969094034	4:8366281-8440723:-	ACOX3	19;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0003997,molecular_function acyl-CoA oxidase activity;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016402,molecular_function pristanoyl-CoA oxidase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase [EC:1.3.3.6]; K00232	acyl-CoA oxidase 3%2C pristanoyl [Source:HGNC Symbol%3BAcc:HGNC:121]
ENSG00000158234	23.99	24.21	24.89	28.72	23.54	27.69	-0.118644319242329	4.13795169353981	0.249532988711015	0.633425969094034	3:138608605-138633376:+	FAIM	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process	NA	Fas apoptotic inhibitory molecule [Source:HGNC Symbol%3BAcc:HGNC:18703]
ENSG00000180398	63.08	54.91	59.13	62.56	60.29	67.70	-0.0897626154931558	5.18592170629563	0.24991184485963	0.634143934725684	2:46901869-46941855:-	MCFD2	15;GO:0000139,cellular_component Golgi membrane;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0046872,molecular_function metal ion binding;GO:0048208,biological_process COPII vesicle coating	NA	multiple coagulation factor deficiency 2 [Source:HGNC Symbol%3BAcc:HGNC:18451]
ENSG00000066629	9.16	9.15	8.42	9.18	9.47	10.17	-0.0993576054828166	4.64487485099875	0.249971303523441	0.634143934725684	14:99737692-99942060:+	EML1	18;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0007052,biological_process mitotic spindle organization;GO:0007405,biological_process neuroblast proliferation;GO:0007420,biological_process brain development;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0015631,molecular_function tubulin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0097431,cellular_component mitotic spindle pole;GO:1990023,cellular_component mitotic spindle midzone	NA	echinoderm microtubule associated protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:3330]
ENSG00000023287	50.10	43.26	50.77	52.04	49.32	52.48	-0.0812324359990416	7.94739277280846	0.250037808126438	0.634143934725684	8:52622455-52745843:-	RB1CC1	29;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0001889,biological_process liver development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006914,biological_process autophagy;GO:0007049,biological_process cell cycle;GO:0007507,biological_process heart development;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0019901,molecular_function protein kinase binding;GO:0030242,biological_process pexophagy;GO:0031965,cellular_component nuclear membrane;GO:0032947,molecular_function protein complex scaffold;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045793,biological_process positive regulation of cell size;GO:0046330,biological_process positive regulation of JNK cascade;GO:0061709,biological_process reticulophagy;GO:0061723,biological_process glycophagy;GO:1990316,cellular_component ATG1/ULK1 kinase complex;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	RB1 inducible coiled-coil 1 [Source:HGNC Symbol%3BAcc:HGNC:15574]
ENSG00000130254	19.70	19.35	17.67	18.26	18.07	17.76	0.0794190991049573	5.73662644924997	0.250044437822445	0.634143934725684	19:5586998-5624046:-	SAFB2	19;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016604,cellular_component nuclear body;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0050684,biological_process regulation of mRNA processing;GO:0060008,biological_process Sertoli cell differentiation;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0070062,cellular_component extracellular exosome	NA	scaffold attachment factor B2 [Source:HGNC Symbol%3BAcc:HGNC:21605]
ENSG00000080608	23.58	25.61	26.09	23.88	22.74	24.96	0.0820217653477767	5.57698603278909	0.250071260813842	0.634143934725684	9:2720468-2844241:-	PUM3	11;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005783,cellular_component endoplasmic reticulum;GO:0006417,biological_process regulation of translation;GO:0010835,biological_process regulation of protein ADP-ribosylation	NA	pumilio RNA binding family member 3 [Source:HGNC Symbol%3BAcc:HGNC:29676]
ENSG00000254122	0.73	0.89	1.00	0.83	0.57	0.73	0.304578297137324	1.23695343477654	0.250213154542159	0.634276517533405	5:141417644-141512979:+	PCDHGB7	9;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protocadherin gamma subfamily B%2C 7 [Source:HGNC Symbol%3BAcc:HGNC:8714]
ENSG00000168061	6.38	7.22	4.78	7.32	7.54	6.18	-0.192887768756915	3.02107168793517	0.250225739656899	0.634276517533405	11:65040900-65044828:+	SAC3D1	NA	NA	SAC3 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30179]
ENSG00000115694	69.52	78.44	70.14	76.66	79.61	75.92	-0.0807198882097351	6.78569634789911	0.250306357706906	0.634294829593558	2:241492673-241509730:-	STK25	32;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0006979,biological_process response to oxidative stress;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0036481,biological_process intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0042542,biological_process response to hydrogen peroxide;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0050772,biological_process positive regulation of axonogenesis;GO:0051645,biological_process Golgi localization;GO:0051683,biological_process establishment of Golgi localization;GO:0070062,cellular_component extracellular exosome;GO:0090168,biological_process Golgi reassembly	NA	serine/threonine kinase 25 [Source:HGNC Symbol%3BAcc:HGNC:11404]
ENSG00000237649	29.81	33.73	30.96	32.35	39.64	30.55	-0.107274256737162	6.16899129656191	0.250388500820067	0.634294829593558	6:33391535-33409924:+	KIFC1	23;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007283,biological_process spermatogenesis;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0051301,biological_process cell division;GO:0090307,biological_process mitotic spindle assembly	NA	kinesin family member C1 [Source:HGNC Symbol%3BAcc:HGNC:6389]
ENSG00000159674	1.92	2.31	1.78	1.21	1.68	1.91	0.314115428248585	0.945865781876489	0.250479890619983	0.634294829593558	4:1166931-1208962:-	SPON2	23;GO:0001530,molecular_function lipopolysaccharide binding;GO:0002376,biological_process immune system process;GO:0002448,biological_process mast cell mediated immunity;GO:0003823,molecular_function antigen binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0007155,biological_process cell adhesion;GO:0007411,biological_process axon guidance;GO:0008228,biological_process opsonization;GO:0032496,biological_process response to lipopolysaccharide;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0042742,biological_process defense response to bacterium;GO:0043152,biological_process induction of bacterial agglutination;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050832,biological_process defense response to fungus;GO:0051607,biological_process defense response to virus;GO:0060907,biological_process positive regulation of macrophage cytokine production;GO:0070062,cellular_component extracellular exosome;GO:0071222,biological_process cellular response to lipopolysaccharide	NA	spondin 2 [Source:HGNC Symbol%3BAcc:HGNC:11253]
ENSG00000110321	366.03	371.94	374.47	388.34	397.41	386.76	-0.0641232960847629	10.0182161071829	0.250512624021518	0.634294829593558	11:10797049-10809110:-	EIF4G2	23;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005913,cellular_component cell-cell adherens junction;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0007050,biological_process cell cycle arrest;GO:0007507,biological_process heart development;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0008219,biological_process cell death;GO:0010507,biological_process negative regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex;GO:0030307,biological_process positive regulation of cell growth;GO:0030424,cellular_component axon;GO:0034645,biological_process cellular macromolecule biosynthetic process;GO:0045296,molecular_function cadherin binding;GO:0045727,biological_process positive regulation of translation;GO:0045773,biological_process positive regulation of axon extension;GO:0060999,biological_process positive regulation of dendritic spine development	EIF4G; translation initiation factor 4G; K03260	eukaryotic translation initiation factor 4 gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:3297]
ENSG00000145780	13.55	12.75	17.30	17.64	14.46	16.11	-0.129155932813001	4.83658311670274	0.250527314776683	0.634294829593558	5:115520907-115544894:-	FEM1C	6;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification	NA	fem-1 homolog C [Source:HGNC Symbol%3BAcc:HGNC:16933]
ENSG00000065457	7.21	9.34	8.10	9.72	8.82	8.65	-0.139481706552441	3.82389458785444	0.250555269308694	0.634294829593558	16:75596980-75623300:-	ADAT1	7;GO:0003723,molecular_function RNA binding;GO:0004000,molecular_function adenosine deaminase activity;GO:0006396,biological_process RNA processing;GO:0008033,biological_process tRNA processing;GO:0008251,molecular_function tRNA-specific adenosine deaminase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	adenosine deaminase%2C tRNA specific 1 [Source:HGNC Symbol%3BAcc:HGNC:228]
ENSG00000135372	20.33	19.92	19.65	20.38	22.57	20.76	-0.0767514089659028	5.9898609792352	0.250638660391658	0.634294829593558	11:34105601-34147670:+	NAT10	30;GO:0000049,molecular_function tRNA binding;GO:0000154,biological_process rRNA modification;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0002101,biological_process tRNA wobble cytosine modification;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008033,biological_process tRNA processing;GO:0008080,molecular_function N-acetyltransferase activity;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016072,biological_process rRNA metabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030496,cellular_component midbody;GO:0030686,cellular_component 90S preribosome;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0034470,biological_process ncRNA processing;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0051391,biological_process tRNA acetylation;GO:0051392,molecular_function tRNA N-acetyltransferase activity;GO:0070182,molecular_function DNA polymerase binding;GO:1904812,biological_process rRNA acetylation involved in maturation of SSU-rRNA;GO:1990883,molecular_function rRNA cytidine N-acetyltransferase activity	NAT10, KRE33; N-acetyltransferase 10 [EC:2.3.1.-]; K14521	N-acetyltransferase 10 [Source:HGNC Symbol%3BAcc:HGNC:29830]
ENSG00000133619	3.55	4.35	3.85	3.49	3.86	3.40	0.13189184809383	3.73156308878722	0.250641757766568	0.634294829593558	7:149714780-149734575:+	KRBA1	6;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process	NA	KRAB-A domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:22228]
ENSG00000221914	22.11	23.56	26.64	25.42	27.45	25.12	-0.0963055147269619	5.25518386571394	0.250746835693572	0.634431404701245	8:26291490-26372680:+	PPP2R2A	18;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000278,biological_process mitotic cell cycle;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0032403,molecular_function protein complex binding;GO:0032502,biological_process developmental process;GO:0043278,biological_process response to morphine;GO:0048156,molecular_function tau protein binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070262,biological_process peptidyl-serine dephosphorylation	PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B; K04354	protein phosphatase 2 regulatory subunit Balpha [Source:HGNC Symbol%3BAcc:HGNC:9304]
ENSG00000131899	18.46	19.24	17.41	17.94	21.46	19.65	-0.0894044553664932	5.93789021726664	0.250925094087494	0.634753045222756	17:18225586-18244875:+	LLGL1	26;GO:0000137,cellular_component Golgi cis cisterna;GO:0000139,cellular_component Golgi membrane;GO:0005096,molecular_function GTPase activator activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006887,biological_process exocytosis;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0007409,biological_process axonogenesis;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0017157,biological_process regulation of exocytosis;GO:0019901,molecular_function protein kinase binding;GO:0030424,cellular_component axon;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031901,cellular_component early endosome membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050708,biological_process regulation of protein secretion	LLGL; lethal(2) giant larvae protein; K06094	LLGL1%2C scribble cell polarity complex component [Source:HGNC Symbol%3BAcc:HGNC:6628]
ENSG00000164040	134.37	146.76	151.50	135.24	140.85	137.29	0.0769229241257105	7.0277758690551	0.251015623209121	0.634852675406443	4:128269236-128288829:-	PGRMC2	9;GO:0003707,molecular_function steroid hormone receptor activity;GO:0005496,molecular_function steroid binding;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0020037,molecular_function heme binding;GO:0043401,biological_process steroid hormone mediated signaling pathway	NA	progesterone receptor membrane component 2 [Source:HGNC Symbol%3BAcc:HGNC:16089]
ENSG00000100629	3.82	3.48	3.34	3.57	4.23	3.97	-0.130900761443637	3.71141876757307	0.251161281598438	0.635091666017806	14:80476982-80959517:-	CEP128	4;GO:0000922,cellular_component spindle pole;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton	NA	centrosomal protein 128 [Source:HGNC Symbol%3BAcc:HGNC:20359]
ENSG00000166816	1.36	1.11	1.47	1.06	0.98	1.18	0.317390274972336	1.00969152668711	0.251226995964885	0.63512845232426	16:75111859-75116771:-	LDHD	9;GO:0003824,molecular_function catalytic activity;GO:0004458,molecular_function D-lactate dehydrogenase (cytochrome) activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016614,molecular_function oxidoreductase activity, acting on CH-OH group of donors;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	LDHD, dld; D-lactate dehydrogenase (cytochrome) [EC:1.1.2.4]; K00102	lactate dehydrogenase D [Source:HGNC Symbol%3BAcc:HGNC:19708]
ENSG00000136826	16.91	10.71	17.47	19.38	13.35	19.28	-0.18835673625407	4.561348530077	0.251382871234877	0.6351797269864	9:107484851-107490482:-	KLF4	87;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000975,molecular_function regulatory region DNA binding;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001010,molecular_function transcription factor activity, sequence-specific DNA binding transcription factor recruiting;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001221,molecular_function transcription cofactor binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005719,cellular_component nuclear euchromatin;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007500,biological_process mesodermal cell fate determination;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009913,biological_process epidermal cell differentiation;GO:0010033,biological_process response to organic substance;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0014740,biological_process negative regulation of muscle hyperplasia;GO:0019827,biological_process stem cell population maintenance;GO:0030154,biological_process cell differentiation;GO:0030336,biological_process negative regulation of cell migration;GO:0031077,biological_process post-embryonic camera-type eye development;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032526,biological_process response to retinoic acid;GO:0034115,biological_process negative regulation of heterotypic cell-cell adhesion;GO:0035014,molecular_function phosphatidylinositol 3-kinase regulator activity;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035166,biological_process post-embryonic hemopoiesis;GO:0042127,biological_process regulation of cell proliferation;GO:0042826,molecular_function histone deacetylase binding;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043551,biological_process regulation of phosphatidylinositol 3-kinase activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044798,cellular_component nuclear transcription factor complex;GO:0045415,biological_process negative regulation of interleukin-8 biosynthetic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045444,biological_process fat cell differentiation;GO:0045595,biological_process regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046985,biological_process positive regulation of hemoglobin biosynthetic process;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0048679,biological_process regulation of axon regeneration;GO:0048730,biological_process epidermis morphogenesis;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060761,biological_process negative regulation of response to cytokine stimulus;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071300,biological_process cellular response to retinoic acid;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071409,biological_process cellular response to cycloheximide;GO:0071499,biological_process cellular response to laminar fluid shear stress;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:1901653,biological_process cellular response to peptide;GO:1904798,biological_process positive regulation of core promoter binding;GO:1904998,biological_process negative regulation of leukocyte adhesion to arterial endothelial cell;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:1990841,molecular_function promoter-specific chromatin binding;GO:2000342,biological_process negative regulation of chemokine (C-X-C motif) ligand 2 production	NA	Kruppel like factor 4 [Source:HGNC Symbol%3BAcc:HGNC:6348]
ENSG00000100599	7.08	6.94	7.70	6.99	6.92	6.55	0.101253775759136	4.51213478946158	0.251391896566811	0.6351797269864	14:92513773-92688994:+	RIN3	13;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	Ras and Rab interactor 3 [Source:HGNC Symbol%3BAcc:HGNC:18751]
ENSG00000241127	17.17	16.74	15.99	16.62	14.88	15.07	0.111086845341346	4.08297357868572	0.251400789388881	0.6351797269864	7:39566375-39610320:+	YAE1D1	2;GO:0006413,biological_process translational initiation;GO:0042273,biological_process ribosomal large subunit biogenesis	NA	Yae1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24857]
ENSG00000125652	54.31	51.69	46.27	44.33	46.57	52.22	0.0995446129568951	5.08058298181023	0.251504877696835	0.635313399847541	19:6372432-6375251:+	ALKBH7	11;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006631,biological_process fatty acid metabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010883,biological_process regulation of lipid storage;GO:0012501,biological_process programmed cell death;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:1902445,biological_process regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	NA	alkB homolog 7 [Source:HGNC Symbol%3BAcc:HGNC:21306]
ENSG00000104237	0.22	0.21	0.21	0.27	0.22	0.29	-0.281471294201224	1.33319956898221	0.251713712361949	0.635711558809536	8:54554360-54871720:+	RP1	29;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007601,biological_process visual perception;GO:0007603,biological_process phototransduction, visible light;GO:0008017,molecular_function microtubule binding;GO:0030030,biological_process cell projection organization;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035082,biological_process axoneme assembly;GO:0035556,biological_process intracellular signal transduction;GO:0035845,biological_process photoreceptor cell outer segment organization;GO:0042461,biological_process photoreceptor cell development;GO:0042995,cellular_component cell projection;GO:0045494,biological_process photoreceptor cell maintenance;GO:0046548,biological_process retinal rod cell development;GO:0046549,biological_process retinal cone cell development;GO:0050896,biological_process response to stimulus;GO:0060041,biological_process retina development in camera-type eye;GO:0060042,biological_process retina morphogenesis in camera-type eye;GO:0071482,biological_process cellular response to light stimulus;GO:0097542,cellular_component ciliary tip;GO:1902857,biological_process positive regulation of nonmotile primary cilium assembly	NA	RP1%2C axonemal microtubule associated [Source:HGNC Symbol%3BAcc:HGNC:10263]
ENSG00000182185	4.65	4.34	5.22	5.21	4.70	6.25	-0.171080323996384	3.02130049718743	0.251922601788771	0.636109694061029	14:67819778-68730218:+	RAD51B	29;GO:0000150,molecular_function recombinase activity;GO:0000166,molecular_function nucleotide binding;GO:0000400,molecular_function four-way junction DNA binding;GO:0000707,biological_process meiotic DNA recombinase assembly;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006312,biological_process mitotic recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007596,biological_process blood coagulation;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0010212,biological_process response to ionizing radiation;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033063,cellular_component Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0042148,biological_process strand invasion	RAD51L1, RAD51B; RAD51-like protein 1; K10869	RAD51 paralog B [Source:HGNC Symbol%3BAcc:HGNC:9822]
ENSG00000137075	14.23	13.15	13.08	12.58	13.39	12.07	0.104344431109498	4.43658263938048	0.252009533720473	0.636186368771914	9:36336395-36487548:-	RNF38	10;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008584,biological_process male gonad development;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0036126,cellular_component sperm flagellum;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 38 [Source:HGNC Symbol%3BAcc:HGNC:18052]
ENSG00000137656	10.69	11.73	9.51	11.25	11.56	11.85	-0.114322266500274	4.37456973042446	0.252055471007836	0.636186368771914	11:116748169-116772988:-	BUD13	6;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0070274,cellular_component RES complex	NA	BUD13 homolog [Source:HGNC Symbol%3BAcc:HGNC:28199]
ENSG00000108439	22.15	22.09	19.49	19.48	20.26	19.68	0.109954532666463	4.15414335710934	0.252329054746347	0.636572029521168	17:47941505-47949308:+	PNPO	15;GO:0004733,molecular_function pyridoxamine-phosphate oxidase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0008615,biological_process pyridoxine biosynthetic process;GO:0010181,molecular_function FMN binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016638,molecular_function oxidoreductase activity, acting on the CH-NH2 group of donors;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042816,biological_process vitamin B6 metabolic process;GO:0042823,biological_process pyridoxal phosphate biosynthetic process;GO:0048037,molecular_function cofactor binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	pdxH, PNPO; pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]; K00275	pyridoxamine 5'-phosphate oxidase [Source:HGNC Symbol%3BAcc:HGNC:30260]
ENSG00000135205	3.89	3.73	4.44	3.76	3.86	3.43	0.14463556086457	3.48689439315151	0.252395819681106	0.636572029521168	7:77122433-77329533:+	CCDC146	3;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton	NA	coiled-coil domain containing 146 [Source:HGNC Symbol%3BAcc:HGNC:29296]
ENSG00000170860	174.95	182.70	145.52	177.15	193.32	172.58	-0.100950149967558	5.74117260284346	0.25263803268084	0.636572029521168	3:14178357-14201119:+	LSM3	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005688,cellular_component U6 snRNP;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1990726,cellular_component Lsm1-7-Pat1 complex	NA	LSM3 homolog%2C U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol%3BAcc:HGNC:17874]
ENSG00000164603	9.50	9.46	9.51	10.31	10.73	10.17	-0.119908974634738	3.70382103287608	0.252675924283283	0.636572029521168	7:112819146-112939916:-	BMT2	6;GO:0005730,cellular_component nucleolus;GO:0008168,molecular_function methyltransferase activity;GO:0016433,molecular_function rRNA (adenine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation	NA	base methyltransferase of 25S rRNA 2 homolog [Source:HGNC Symbol%3BAcc:HGNC:26475]
ENSG00000196199	14.13	14.44	14.29	13.99	13.15	13.70	0.0798773701005657	5.26219188704456	0.252687860540416	0.636572029521168	13:19633680-19673459:+	MPHOSPH8	19;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000788,cellular_component nuclear nucleosome;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005720,cellular_component nuclear heterochromatin;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016567,biological_process protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035064,molecular_function methylated histone binding;GO:0044030,biological_process regulation of DNA methylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070062,cellular_component extracellular exosome	NA	M-phase phosphoprotein 8 [Source:HGNC Symbol%3BAcc:HGNC:29810]
ENSG00000179965	4.47	3.69	4.37	3.11	4.28	3.48	0.22991847482777	2.03675933364909	0.252774566241664	0.636572029521168	16:30407296-30431108:+	ZNF771	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 771 [Source:HGNC Symbol%3BAcc:HGNC:29653]
ENSG00000139725	14.86	16.71	14.61	15.42	12.47	13.96	0.145500658451646	3.32500516484911	0.252839321534283	0.636572029521168	12:121777753-121803403:-	RHOF	15;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007015,biological_process actin filament organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome	NA	ras homolog family member F%2C filopodia associated [Source:HGNC Symbol%3BAcc:HGNC:15703]
ENSG00000170638	33.58	29.39	36.02	33.95	29.39	29.72	0.106076109742859	5.19591766268854	0.25289324540967	0.636572029521168	22:50185914-50199598:+	TRABD	NA	NA	TraB domain containing [Source:HGNC Symbol%3BAcc:HGNC:28805]
ENSG00000119718	31.83	35.49	38.14	32.79	29.62	36.38	0.104069263338041	5.22758654917672	0.252905162334411	0.636572029521168	14:75002910-75012366:+	EIF2B2	21;GO:0001541,biological_process ovarian follicle development;GO:0003743,molecular_function translation initiation factor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005851,cellular_component eukaryotic translation initiation factor 2B complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0007417,biological_process central nervous system development;GO:0009408,biological_process response to heat;GO:0009749,biological_process response to glucose;GO:0014003,biological_process oligodendrocyte development;GO:0042552,biological_process myelination;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044237,biological_process cellular metabolic process;GO:0051716,biological_process cellular response to stimulus	EIF2B2; translation initiation factor eIF-2B subunit beta; K03754	eukaryotic translation initiation factor 2B subunit beta [Source:HGNC Symbol%3BAcc:HGNC:3258]
ENSG00000142453	36.80	36.00	36.34	40.32	39.96	35.94	-0.0778696178334764	6.1597571336479	0.252919099952846	0.636572029521168	19:10871512-10923070:+	CARM1	51;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0003420,biological_process regulation of growth plate cartilage chondrocyte proliferation;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006479,biological_process protein methylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007568,biological_process aging;GO:0008013,molecular_function beta-catenin binding;GO:0008168,molecular_function methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008469,molecular_function histone-arginine N-methyltransferase activity;GO:0016032,biological_process viral process;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019919,biological_process peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0032091,biological_process negative regulation of protein binding;GO:0032259,biological_process methylation;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0034969,biological_process histone arginine methylation;GO:0034970,biological_process histone H3-R2 methylation;GO:0034971,biological_process histone H3-R17 methylation;GO:0035242,molecular_function protein-arginine omega-N asymmetric methyltransferase activity;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0035642,molecular_function histone methyltransferase activity (H3-R17 specific);GO:0042054,molecular_function histone methyltransferase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051591,biological_process response to cAMP;GO:0060350,biological_process endochondral bone morphogenesis;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0071168,biological_process protein localization to chromatin;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1902415,biological_process regulation of mRNA binding;GO:2000171,biological_process negative regulation of dendrite development	CARM1, PRMT4; type I protein arginine methyltransferase [EC:2.1.1.319]; K05931	coactivator associated arginine methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:23393]
ENSG00000149212	1.31	0.95	0.78	0.89	1.91	1.21	-0.374908290378958	0.954094564516464	0.252963346109084	0.636572029521168	11:95165512-95232541:-	SESN3	16;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016491,molecular_function oxidoreductase activity;GO:0031932,cellular_component TORC2 complex;GO:0032868,biological_process response to insulin;GO:0034198,biological_process cellular response to amino acid starvation;GO:0038203,biological_process TORC2 signaling;GO:0042149,biological_process cellular response to glucose starvation;GO:0042593,biological_process glucose homeostasis;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0051896,biological_process regulation of protein kinase B signaling;GO:0055114,biological_process oxidation-reduction process;GO:0061700,cellular_component GATOR2 complex;GO:0071230,biological_process cellular response to amino acid stimulus;GO:1901031,biological_process regulation of response to reactive oxygen species;GO:1904262,biological_process negative regulation of TORC1 signaling	SESN1_3; sestrin 1/3; K10141	sestrin 3 [Source:HGNC Symbol%3BAcc:HGNC:23060]
ENSG00000131558	45.29	47.10	43.87	44.12	43.47	43.07	0.0712718365651377	7.02536507905437	0.252993731879939	0.636572029521168	7:133253072-134066589:+	EXOC4	24;GO:0000145,cellular_component exocyst;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0006903,biological_process vesicle targeting;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0007268,biological_process chemical synaptic transmission;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0017160,molecular_function Ral GTPase binding;GO:0030165,molecular_function PDZ domain binding;GO:0030496,cellular_component midbody;GO:0032584,cellular_component growth cone membrane;GO:0035748,cellular_component myelin sheath abaxonal region;GO:0045202,cellular_component synapse;GO:0047485,molecular_function protein N-terminus binding;GO:0048341,biological_process paraxial mesoderm formation	NA	exocyst complex component 4 [Source:HGNC Symbol%3BAcc:HGNC:30389]
ENSG00000144724	24.31	25.18	24.33	25.77	26.10	26.26	-0.071217185303267	6.78127235744794	0.253027458540757	0.636572029521168	3:61561568-62297613:+	PTPRG	19;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007420,biological_process brain development;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042802,molecular_function identical protein binding;GO:0070062,cellular_component extracellular exosome	NA	protein tyrosine phosphatase%2C receptor type G [Source:HGNC Symbol%3BAcc:HGNC:9671]
ENSG00000198954	20.83	22.13	18.59	19.66	19.38	19.23	0.0866340581254554	5.51777939274868	0.253039638630666	0.636572029521168	10:68988720-69043544:+	KIF1BP	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005856,cellular_component cytoskeleton;GO:0006839,biological_process mitochondrial transport;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0019894,molecular_function kinesin binding;GO:0030154,biological_process cell differentiation	NA	KIF1 binding protein [Source:HGNC Symbol%3BAcc:HGNC:23419]
ENSG00000095002	29.16	31.43	28.02	31.06	31.28	31.79	-0.0779090612071932	6.48283288146884	0.253044750260792	0.636572029521168	2:47402968-47562311:+	MSH2	65;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000400,molecular_function four-way junction DNA binding;GO:0000403,molecular_function Y-form DNA binding;GO:0000404,molecular_function heteroduplex DNA loop binding;GO:0000406,molecular_function double-strand/single-strand DNA junction binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001701,biological_process in utero embryonic development;GO:0002204,biological_process somatic recombination of immunoglobulin genes involved in immune response;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006119,biological_process oxidative phosphorylation;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006301,biological_process postreplication repair;GO:0006302,biological_process double-strand break repair;GO:0006311,biological_process meiotic gene conversion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0007281,biological_process germ cell development;GO:0008022,molecular_function protein C-terminus binding;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008340,biological_process determination of adult lifespan;GO:0008584,biological_process male gonad development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010165,biological_process response to X-ray;GO:0010224,biological_process response to UV-B;GO:0016020,cellular_component membrane;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016447,biological_process somatic recombination of immunoglobulin gene segments;GO:0016887,molecular_function ATPase activity;GO:0019237,molecular_function centromeric DNA binding;GO:0019724,biological_process B cell mediated immunity;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030183,biological_process B cell differentiation;GO:0030983,molecular_function mismatched DNA binding;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0032137,molecular_function guanine/thymine mispair binding;GO:0032139,molecular_function dinucleotide insertion or deletion binding;GO:0032142,molecular_function single guanine insertion binding;GO:0032143,molecular_function single thymine insertion binding;GO:0032181,molecular_function dinucleotide repeat insertion binding;GO:0032300,cellular_component mismatch repair complex;GO:0032301,cellular_component MutSalpha complex;GO:0032302,cellular_component MutSbeta complex;GO:0032357,molecular_function oxidized purine DNA binding;GO:0032405,molecular_function MutLalpha complex binding;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042803,molecular_function protein homodimerization activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043531,molecular_function ADP binding;GO:0043570,biological_process maintenance of DNA repeat elements;GO:0045128,biological_process negative regulation of reciprocal meiotic recombination;GO:0045190,biological_process isotype switching;GO:0045910,biological_process negative regulation of DNA recombination;GO:0048298,biological_process positive regulation of isotype switching to IgA isotypes;GO:0048304,biological_process positive regulation of isotype switching to IgG isotypes;GO:0051096,biological_process positive regulation of helicase activity	MSH2; DNA mismatch repair protein MSH2; K08735	mutS homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:7325]
ENSG00000161981	30.34	38.84	29.92	38.21	39.23	32.48	-0.147740426559783	3.92378595293184	0.253046869421919	0.636572029521168	16:53009-57669:+	SNRNP25	10;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0045171,cellular_component intercellular bridge	NA	small nuclear ribonucleoprotein U11/U12 subunit 25 [Source:HGNC Symbol%3BAcc:HGNC:14161]
ENSG00000167306	11.10	10.96	10.00	11.22	12.33	10.73	-0.0853421879793122	5.94180667653409	0.253209796805702	0.636572029521168	18:49822812-50195093:-	MYO5B	20;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0003091,biological_process renal water homeostasis;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0016459,cellular_component myosin complex;GO:0017137,molecular_function Rab GTPase binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0032439,biological_process endosome localization;GO:0043234,cellular_component protein complex;GO:0045179,cellular_component apical cortex;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome	MYO5; myosin V; K10357	myosin VB [Source:HGNC Symbol%3BAcc:HGNC:7603]
ENSG00000172493	33.59	36.99	38.28	36.05	41.73	38.67	-0.0857757371885255	7.15231272803478	0.253296494668743	0.636572029521168	4:86935001-87141054:+	AFF1	5;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008023,cellular_component transcription elongation factor complex	AFF1; AF4/FMR2 family member 1; K15184	AF4/FMR2 family member 1 [Source:HGNC Symbol%3BAcc:HGNC:7135]
ENSG00000160613	10.04	10.30	8.50	6.90	10.37	8.92	0.148944989580532	4.44070560358897	0.253316620606096	0.636572029521168	11:117204336-117232525:-	PCSK7	11;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016486,biological_process peptide hormone processing;GO:0016787,molecular_function hydrolase activity;GO:0030173,cellular_component integral component of Golgi membrane	NA	proprotein convertase subtilisin/kexin type 7 [Source:HGNC Symbol%3BAcc:HGNC:8748]
ENSG00000143436	50.18	46.99	46.60	54.02	49.28	50.27	-0.0818268266120606	5.49373166674505	0.253322453679571	0.636572029521168	1:151759642-151763564:-	MRPL9	13;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L9, MRPL9, rplI; large subunit ribosomal protein L9; K02939	mitochondrial ribosomal protein L9 [Source:HGNC Symbol%3BAcc:HGNC:14277]
ENSG00000175106	1.42	1.64	2.32	2.72	1.96	2.08	-0.310094484186428	1.18872241523995	0.253341788305949	0.636572029521168	17:15502263-15563595:-	TVP23C	5;GO:0009306,biological_process protein secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030173,cellular_component integral component of Golgi membrane	NA	trans-golgi network vesicle protein 23 homolog C [Source:HGNC Symbol%3BAcc:HGNC:30453]
ENSG00000278619	6.34	6.86	7.09	5.44	5.66	6.97	0.172020422040827	2.79030725224766	0.253382187475196	0.636572029521168	17:36601571-36608971:+	MRM1	14;GO:0000451,biological_process rRNA 2'-O-methylation;GO:0000453,biological_process enzyme-directed rRNA 2'-O-methylation;GO:0001510,biological_process RNA methylation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0070039,molecular_function rRNA (guanosine-2'-O-)-methyltransferase activity	NA	mitochondrial rRNA methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:26202]
ENSG00000184903	21.69	21.29	20.40	22.48	22.05	24.46	-0.11250046232171	4.03708911945434	0.253440512656098	0.636572029521168	7:110663050-111562517:-	IMMP2L	21;GO:0001541,biological_process ovarian follicle development;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0006627,biological_process protein processing involved in protein targeting to mitochondrion;GO:0006801,biological_process superoxide metabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0007420,biological_process brain development;GO:0008015,biological_process blood circulation;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0022904,biological_process respiratory electron transport chain;GO:0030728,biological_process ovulation;GO:0033108,biological_process mitochondrial respiratory chain complex assembly;GO:0042720,cellular_component mitochondrial inner membrane peptidase complex;GO:0061300,biological_process cerebellum vasculature development	IMP2; mitochondrial inner membrane protease subunit 2 [EC:3.4.21.-]; K09648	inner mitochondrial membrane peptidase subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:14598]
ENSG00000134825	178.26	165.74	171.92	163.56	161.20	168.40	0.0789775463903857	5.51653348641655	0.253440637312958	0.636572029521168	11:61768500-61792802:-	TMEM258	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034998,cellular_component oligosaccharyltransferase I complex	NA	transmembrane protein 258 [Source:HGNC Symbol%3BAcc:HGNC:1164]
ENSG00000104133	12.94	13.55	14.23	11.72	13.83	13.15	0.0851095039532356	6.64377299705896	0.253490336093059	0.636572029521168	15:44562695-44663678:-	SPG11	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007040,biological_process lysosome organization;GO:0007268,biological_process chemical synaptic transmission;GO:0008088,biological_process axo-dendritic transport;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0048489,biological_process synaptic vesicle transport;GO:0048675,biological_process axon extension;GO:0070062,cellular_component extracellular exosome;GO:0090389,biological_process phagosome-lysosome fusion involved in apoptotic cell clearance;GO:0090659,biological_process walking behavior	NA	SPG11%2C spatacsin vesicle trafficking associated [Source:HGNC Symbol%3BAcc:HGNC:11226]
ENSG00000214078	93.27	90.89	89.12	94.88	100.07	94.38	-0.0703851946668586	7.36814051468302	0.253595999257183	0.636708563668976	20:35626030-35664956:-	CPNE1	34;GO:0001786,molecular_function phosphatidylserine binding;GO:0004175,molecular_function endopeptidase activity;GO:0005215,molecular_function transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030154,biological_process cell differentiation;GO:0031965,cellular_component nuclear membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043312,biological_process neutrophil degranulation;GO:0043392,biological_process negative regulation of DNA binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0046474,biological_process glycerophospholipid biosynthetic process;GO:0051059,molecular_function NF-kappaB binding;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome;GO:0071277,biological_process cellular response to calcium ion;GO:1901223,biological_process negative regulation of NIK/NF-kappaB signaling;GO:1903265,biological_process positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1990138,biological_process neuron projection extension	NA	copine 1 [Source:HGNC Symbol%3BAcc:HGNC:2314]
ENSG00000168802	43.34	46.42	45.26	45.07	48.67	49.79	-0.0774978365970916	6.68564777756223	0.253808156192308	0.636807389312576	16:69118009-69132584:-	CHTF8	11;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0007049,biological_process cell cycle;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0070062,cellular_component extracellular exosome;GO:1900264,biological_process positive regulation of DNA-directed DNA polymerase activity	NA	chromosome transmission fidelity factor 8 [Source:HGNC Symbol%3BAcc:HGNC:24353]
ENSG00000140263	15.72	16.24	15.43	18.67	17.80	15.29	-0.115595647375284	4.27087724394181	0.253813124264595	0.636807389312576	15:45023103-45077185:+	SORD	32;GO:0003939,molecular_function L-iditol 2-dehydrogenase activity;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0006006,biological_process glucose metabolic process;GO:0006060,biological_process sorbitol metabolic process;GO:0006062,biological_process sorbitol catabolic process;GO:0006970,biological_process response to osmotic stress;GO:0008270,molecular_function zinc ion binding;GO:0009725,biological_process response to hormone;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019640,biological_process glucuronate catabolic process to xylulose 5-phosphate;GO:0030246,molecular_function carbohydrate binding;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0031667,biological_process response to nutrient levels;GO:0031966,cellular_component mitochondrial membrane;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0046370,biological_process fructose biosynthetic process;GO:0046526,molecular_function D-xylulose reductase activity;GO:0046686,biological_process response to cadmium ion;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0051160,biological_process L-xylitol catabolic process;GO:0051164,biological_process L-xylitol metabolic process;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]; K00008	sorbitol dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:11184]
ENSG00000065548	73.19	69.60	73.13	75.25	74.44	79.35	-0.0723647297444584	6.70366956306637	0.253835131007065	0.636807389312576	2:186486155-186509363:+	ZC3H15	9;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 15 [Source:HGNC Symbol%3BAcc:HGNC:29528]
ENSG00000170262	5.04	5.58	5.50	5.96	6.03	7.08	-0.237540925148813	1.91596868580496	0.253840567334136	0.636807389312576	21:32291812-32314784:+	MRAP	14;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031780,molecular_function corticotropin hormone receptor binding;GO:0031781,molecular_function type 3 melanocortin receptor binding;GO:0031782,molecular_function type 4 melanocortin receptor binding;GO:0031783,molecular_function type 5 melanocortin receptor binding;GO:0034394,biological_process protein localization to cell surface;GO:0050873,biological_process brown fat cell differentiation;GO:0070996,molecular_function type 1 melanocortin receptor binding	NA	melanocortin 2 receptor accessory protein [Source:HGNC Symbol%3BAcc:HGNC:1304]
ENSG00000164989	0.99	0.84	0.58	0.94	0.95	0.98	-0.241343996362675	1.90613486615436	0.254035887153544	0.636910772503468	9:15553085-16061663:+	CCDC171	NA	NA	coiled-coil domain containing 171 [Source:HGNC Symbol%3BAcc:HGNC:29828]
ENSG00000205643	14.88	11.92	15.05	12.40	11.63	13.52	0.17942647047602	2.73465891724109	0.254047159579664	0.636910772503468	22:46244010-46250679:-	CDPF1	1;GO:0005515,molecular_function protein binding	NA	cysteine rich DPF motif domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:33710]
ENSG00000198538	4.60	5.13	4.89	4.94	6.41	4.98	-0.150389406273904	3.56865210550409	0.254099400872929	0.636910772503468	19:52797408-52857600:-	ZNF28	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 28 [Source:HGNC Symbol%3BAcc:HGNC:13073]
ENSG00000108298	1461.73	1463.34	1443.62	1609.35	1484.91	1520.40	-0.0673342261777441	9.93434727604387	0.254119880732803	0.636910772503468	17:39200282-39204727:+	RPL19	16;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L19e, RPL19; large subunit ribosomal protein L19e; K02885	ribosomal protein L19 [Source:HGNC Symbol%3BAcc:HGNC:10312]
ENSG00000157625	6.55	6.60	7.34	7.71	7.39	7.31	-0.113932021119705	3.96311819217057	0.254138327254465	0.636910772503468	X:30827441-30975084:-	TAB3	15;GO:0000187,biological_process activation of MAPK activity;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0010008,cellular_component endosome membrane;GO:0010507,biological_process negative regulation of autophagy;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway	MAP3K7IP3, TAB3; TAK1-binding protein 3; K12793	TGF-beta activated kinase 1 and MAP3K7 binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:30681]
ENSG00000272617	1.57	1.21	0.89	1.36	1.38	1.78	-0.285840537593541	1.52260931948504	0.254263852656026	0.636911014678155	16:69326912-69339667:-	COG8	10;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032588,cellular_component trans-Golgi network membrane	NA	component of oligomeric golgi complex 8 [Source:HGNC Symbol%3BAcc:HGNC:18623]
ENSG00000141665	0.53	0.93	0.51	0.77	0.70	1.09	-0.418082120928126	0.543097386111718	0.254266111653862	0.636911014678155	18:74073352-74147865:-	FBXO15	6;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	F-box protein 15 [Source:HGNC Symbol%3BAcc:HGNC:13617]
ENSG00000164975	25.47	21.06	24.10	24.21	25.87	26.33	-0.0948852825619696	4.93052380087766	0.254323819756308	0.636911014678155	9:15422703-15465953:+	SNAPC3	12;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0009301,biological_process snRNA transcription;GO:0016604,cellular_component nuclear body;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	small nuclear RNA activating complex polypeptide 3 [Source:HGNC Symbol%3BAcc:HGNC:11136]
ENSG00000089775	11.69	8.59	11.97	12.34	9.99	14.16	-0.15850357661716	4.01826436905292	0.254343663881383	0.636911014678155	14:64449105-64505213:-	ZBTB25	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010467,biological_process gene expression;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 25 [Source:HGNC Symbol%3BAcc:HGNC:13112]
ENSG00000122970	19.27	21.56	19.65	20.16	23.53	21.19	-0.0925434629914903	5.55711323480088	0.25439788621097	0.636918306078412	12:110124334-110218797:+	IFT81	15;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0007283,biological_process spermatogenesis;GO:0015631,molecular_function tubulin binding;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0031514,cellular_component motile cilium;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097225,cellular_component sperm midpiece;GO:0097228,cellular_component sperm principal piece;GO:0097542,cellular_component ciliary tip	NA	intraflagellar transport 81 [Source:HGNC Symbol%3BAcc:HGNC:14313]
ENSG00000166289	6.58	5.48	4.57	8.14	5.98	5.54	-0.224858271179782	2.38673640315511	0.25459501624707	0.63728331048092	19:29665055-29675457:+	PLEKHF1	18;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006915,biological_process apoptotic process;GO:0007032,biological_process endosome organization;GO:0010008,cellular_component endosome membrane;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0010508,biological_process positive regulation of autophagy;GO:0016050,biological_process vesicle organization;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0072659,biological_process protein localization to plasma membrane;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	NA	pleckstrin homology and FYVE domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20764]
ENSG00000166848	22.03	19.81	22.63	22.92	23.32	22.93	-0.0840584865558155	5.12666138453812	0.25472510146297	0.637480379931421	16:75647785-75761872:+	TERF2IP	36;GO:0000228,cellular_component nuclear chromosome;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007004,biological_process telomere maintenance via telomerase;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0010833,biological_process telomere maintenance via telomere lengthening;GO:0016233,biological_process telomere capping;GO:0016604,cellular_component nuclear body;GO:0019902,molecular_function phosphatase binding;GO:0030870,cellular_component Mre11 complex;GO:0031848,biological_process protection from non-homologous end joining at telomere;GO:0032204,biological_process regulation of telomere maintenance;GO:0032205,biological_process negative regulation of telomere maintenance;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0042162,molecular_function telomeric DNA binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048239,biological_process negative regulation of DNA recombination at telomere;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070187,cellular_component telosome;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1901985,biological_process positive regulation of protein acetylation	NA	TERF2 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:19246]
ENSG00000148481	21.89	21.02	20.80	21.05	20.04	19.25	0.0918259164786266	4.81635736170462	0.25486072146104	0.637600001081128	10:15778169-15860520:-	MINDY3	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016807,molecular_function cysteine-type carboxypeptidase activity;GO:0031965,cellular_component nuclear membrane;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0071108,biological_process protein K48-linked deubiquitination;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	NA	MINDY lysine 48 deubiquitinase 3 [Source:HGNC Symbol%3BAcc:HGNC:23578]
ENSG00000141452	38.81	34.28	36.28	37.26	32.33	34.49	0.0852869717762302	6.22918434441694	0.254924835227271	0.637600001081128	18:23503469-23531807:+	C18orf8	1;GO:0005765,cellular_component lysosomal membrane	NA	chromosome 18 open reading frame 8 [Source:HGNC Symbol%3BAcc:HGNC:24326]
ENSG00000164976	1.71	2.05	1.55	1.57	1.49	1.48	0.223130428809862	1.86373363091132	0.254926996323664	0.637600001081128	9:34366669-34376853:-	KIAA1161	11;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005975,biological_process carbohydrate metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0031965,cellular_component nuclear membrane;GO:0043568,biological_process positive regulation of insulin-like growth factor receptor signaling pathway;GO:0048741,biological_process skeletal muscle fiber development;GO:0051897,biological_process positive regulation of protein kinase B signaling	NA	KIAA1161 [Source:HGNC Symbol%3BAcc:HGNC:19918]
ENSG00000176771	0.53	0.46	0.47	0.46	0.37	0.40	0.266131539561346	1.50463084410446	0.255069079222378	0.637826849393107	2:132671798-133568463:-	NCKAP5	2;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	NCK associated protein 5 [Source:HGNC Symbol%3BAcc:HGNC:29847]
ENSG00000198081	16.04	15.32	17.32	18.23	17.00	17.44	-0.0975221827517305	4.5210802701928	0.255136309181114	0.637866466438101	18:5289018-5297053:-	ZBTB14	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003170,biological_process heart valve development;GO:0003279,biological_process cardiac septum development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016235,cellular_component aggresome;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0060976,biological_process coronary vasculature development	NA	zinc finger and BTB domain containing 14 [Source:HGNC Symbol%3BAcc:HGNC:12860]
ENSG00000197768	5.25	4.70	6.29	4.91	4.45	5.10	0.187414624170766	2.60921602963132	0.255379189331463	0.638306762778829	9:137251260-137253483:+	STPG3	NA	NA	sperm-tail PG-rich repeat containing 3 [Source:HGNC Symbol%3BAcc:HGNC:37285]
ENSG00000205208	8.96	7.33	8.03	7.73	10.96	10.58	-0.245322571707744	1.67909325190542	0.255415265505715	0.638306762778829	4:158666678-158672255:-	C4orf46	2;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm	NA	chromosome 4 open reading frame 46 [Source:HGNC Symbol%3BAcc:HGNC:27320]
ENSG00000139278	19.51	24.41	24.05	19.64	21.99	21.20	0.11884190923115	4.25145643276513	0.255657156244324	0.638782665149113	12:75480679-75503853:+	GLIPR1	7;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation	NA	GLI pathogenesis related 1 [Source:HGNC Symbol%3BAcc:HGNC:17001]
ENSG00000099999	7.95	8.51	7.40	6.31	7.85	7.70	0.131720861593543	3.67629678751318	0.255904768687196	0.639038498184032	22:30368810-30421771:-	RNF215	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 215 [Source:HGNC Symbol%3BAcc:HGNC:33434]
ENSG00000174010	3.47	3.74	3.98	4.34	4.27	4.00	-0.159784271623394	2.87709201999714	0.25594299356747	0.639038498184032	X:23983719-24027186:-	KLHL15	8;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0071630,biological_process nucleus-associated proteasomal ubiquitin-dependent protein catabolic process;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination	NA	kelch like family member 15 [Source:HGNC Symbol%3BAcc:HGNC:29347]
ENSG00000164897	57.04	57.11	55.35	56.51	52.93	52.12	0.0806183766117565	5.35305030969788	0.255960745085698	0.639038498184032	7:151081079-151083546:-	TMUB1	17;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0055037,cellular_component recycling endosome	NA	transmembrane and ubiquitin like domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21709]
ENSG00000147854	28.23	26.73	27.91	29.34	27.36	31.59	-0.078978135948346	6.12740860350633	0.255965472727867	0.639038498184032	9:6413150-6507054:+	UHRF2	19;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005720,cellular_component nuclear heterochromatin;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0010216,biological_process maintenance of DNA methylation;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0090308,biological_process regulation of methylation-dependent chromatin silencing	NA	ubiquitin like with PHD and ring finger domains 2 [Source:HGNC Symbol%3BAcc:HGNC:12557]
ENSG00000140575	66.31	65.22	65.32	62.93	62.77	64.12	0.064274376543941	8.341957248529	0.256047983869824	0.639074520129418	15:90388217-90502243:+	IQGAP1	66;GO:0001726,cellular_component ruffle;GO:0001817,biological_process regulation of cytokine production;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0015629,cellular_component actin cytoskeleton;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0017048,molecular_function Rho GTPase binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030667,cellular_component secretory granule membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031252,cellular_component cell leading edge;GO:0032403,molecular_function protein complex binding;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035305,biological_process negative regulation of dephosphorylation;GO:0036057,cellular_component slit diaphragm;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0043005,cellular_component neuron projection;GO:0043087,biological_process regulation of GTPase activity;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0044548,molecular_function S100 protein binding;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0070062,cellular_component extracellular exosome;GO:0071277,biological_process cellular response to calcium ion;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0072015,biological_process glomerular visceral epithelial cell development;GO:1900006,biological_process positive regulation of dendrite development;GO:1900086,biological_process positive regulation of peptidyl-tyrosine autophosphorylation;GO:1903829,biological_process positive regulation of cellular protein localization;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:1990138,biological_process neuron projection extension;GO:1990776,biological_process response to angiotensin	IQGAP1; Ras GTPase-activating-like protein IQGAP1; K16848	IQ motif containing GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6110]
ENSG00000123374	24.54	24.83	22.88	22.48	23.36	22.33	0.0935883034924162	4.61191921859214	0.256098776715604	0.639074520129418	12:55966768-55972784:+	CDK2	63;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0000781,cellular_component chromosome, telomeric region;GO:0000793,cellular_component condensed chromosome;GO:0000805,cellular_component X chromosome;GO:0000806,cellular_component Y chromosome;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006468,biological_process protein phosphorylation;GO:0006813,biological_process potassium ion transport;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007099,biological_process centriole replication;GO:0007265,biological_process Ras protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010033,biological_process response to organic substance;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015030,cellular_component Cajal body;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016572,biological_process histone phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019904,molecular_function protein domain specific binding;GO:0030332,molecular_function cyclin binding;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0032298,biological_process positive regulation of DNA-dependent DNA replication initiation;GO:0035173,molecular_function histone kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051298,biological_process centrosome duplication;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051726,biological_process regulation of cell cycle;GO:0060968,biological_process regulation of gene silencing;GO:0071732,biological_process cellular response to nitric oxide;GO:0097123,cellular_component cyclin A1-CDK2 complex;GO:0097124,cellular_component cyclin A2-CDK2 complex;GO:0097134,cellular_component cyclin E1-CDK2 complex;GO:0097135,cellular_component cyclin E2-CDK2 complex;GO:0097472,molecular_function cyclin-dependent protein kinase activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]; K02206	cyclin dependent kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:1771]
ENSG00000142892	55.44	60.54	53.83	52.69	52.99	56.20	0.07718489447906	6.04847878924077	0.256134354116157	0.639074520129418	1:77088989-77219430:-	PIGK	17;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0003923,molecular_function GPI-anchor transamidase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016255,biological_process attachment of GPI anchor to protein;GO:0016787,molecular_function hydrolase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034235,molecular_function GPI anchor binding;GO:0034394,biological_process protein localization to cell surface;GO:0042765,cellular_component GPI-anchor transamidase complex	PIGK; GPI-anchor transamidase subunit K; K05290	phosphatidylinositol glycan anchor biosynthesis class K [Source:HGNC Symbol%3BAcc:HGNC:8965]
ENSG00000154743	10.67	9.49	8.93	8.53	8.74	9.68	0.123134617267749	3.95398153294442	0.256308345919341	0.639380124175399	3:12484431-12539623:+	TSEN2	17;GO:0000213,molecular_function tRNA-intron endonuclease activity;GO:0000214,cellular_component tRNA-intron endonuclease complex;GO:0000379,biological_process tRNA-type intron splice site recognition and cleavage;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0008033,biological_process tRNA processing;GO:0016829,molecular_function lyase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	tRNA splicing endonuclease subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:28422]
ENSG00000131323	11.71	9.99	11.54	12.93	10.42	13.22	-0.121297567467186	4.37338277319699	0.256361763146582	0.639384883652507	14:102777475-102911500:+	TRAF3	34;GO:0001817,biological_process regulation of cytokine production;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008063,biological_process Toll signaling pathway;GO:0008270,molecular_function zinc ion binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031996,molecular_function thioesterase binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032648,biological_process regulation of interferon-beta production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0035631,cellular_component CD40 receptor complex;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050688,biological_process regulation of defense response to virus	TRAF3; TNF receptor-associated factor 3; K03174	TNF receptor associated factor 3 [Source:HGNC Symbol%3BAcc:HGNC:12033]
ENSG00000178567	10.73	10.31	10.36	9.39	10.16	9.98	0.102378205146293	4.26829182110672	0.256522310641145	0.639622864252976	3:36985042-36993168:-	EPM2AIP1	12;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0032868,biological_process response to insulin;GO:0042802,molecular_function identical protein binding;GO:0045725,biological_process positive regulation of glycogen biosynthetic process;GO:2000467,biological_process positive regulation of glycogen (starch) synthase activity	NA	EPM2A interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19735]
ENSG00000186523	2.01	1.02	1.36	1.28	1.13	1.15	0.343809467797797	1.02704071171022	0.25656023854955	0.639622864252976	8:12182095-12194133:-	FAM86B1	3;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	family with sequence similarity 86 member B1 [Source:HGNC Symbol%3BAcc:HGNC:28268]
ENSG00000106571	4.49	4.09	4.01	5.05	4.02	4.69	-0.114972116230264	4.44252174252935	0.256716972267159	0.639760094671768	7:41960949-42237870:-	GLI3	121;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001656,biological_process metanephros development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007224,biological_process smoothened signaling pathway;GO:0007389,biological_process pattern specification process;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0007442,biological_process hindgut morphogenesis;GO:0007507,biological_process heart development;GO:0008013,molecular_function beta-catenin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009954,biological_process proximal/distal pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0016485,biological_process protein processing;GO:0016592,cellular_component mediator complex;GO:0016607,cellular_component nuclear speck;GO:0017053,cellular_component transcriptional repressor complex;GO:0021513,biological_process spinal cord dorsal/ventral patterning;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021537,biological_process telencephalon development;GO:0021543,biological_process pallium development;GO:0021544,biological_process subpallium development;GO:0021631,biological_process optic nerve morphogenesis;GO:0021766,biological_process hippocampus development;GO:0021775,biological_process smoothened signaling pathway involved in ventral spinal cord interneuron specification;GO:0021776,biological_process smoothened signaling pathway involved in spinal cord motor neuron cell fate specification;GO:0021798,biological_process forebrain dorsal/ventral pattern formation;GO:0021801,biological_process cerebral cortex radial glia guided migration;GO:0021819,biological_process layer formation in cerebral cortex;GO:0021861,biological_process forebrain radial glial cell differentiation;GO:0021915,biological_process neural tube development;GO:0022018,biological_process lateral ganglionic eminence cell proliferation;GO:0030318,biological_process melanocyte differentiation;GO:0030324,biological_process lung development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030850,biological_process prostate gland development;GO:0030879,biological_process mammary gland development;GO:0030900,biological_process forebrain development;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0033077,biological_process T cell differentiation in thymus;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035108,biological_process limb morphogenesis;GO:0035295,biological_process tube development;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042826,molecular_function histone deacetylase binding;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043585,biological_process nose morphogenesis;GO:0043586,biological_process tongue development;GO:0043627,biological_process response to estrogen;GO:0045060,biological_process negative thymic T cell selection;GO:0045595,biological_process regulation of cell differentiation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046638,biological_process positive regulation of alpha-beta T cell differentiation;GO:0046639,biological_process negative regulation of alpha-beta T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048566,biological_process embryonic digestive tract development;GO:0048568,biological_process embryonic organ development;GO:0048589,biological_process developmental growth;GO:0048593,biological_process camera-type eye morphogenesis;GO:0048598,biological_process embryonic morphogenesis;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048663,biological_process neuron fate commitment;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048709,biological_process oligodendrocyte differentiation;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048839,biological_process inner ear development;GO:0048856,biological_process anatomical structure development;GO:0060021,biological_process palate development;GO:0060173,biological_process limb development;GO:0060364,biological_process frontal suture morphogenesis;GO:0060366,biological_process lambdoid suture morphogenesis;GO:0060367,biological_process sagittal suture morphogenesis;GO:0060594,biological_process mammary gland specification;GO:0060831,biological_process smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0060840,biological_process artery development;GO:0060873,biological_process anterior semicircular canal development;GO:0060875,biological_process lateral semicircular canal development;GO:0061005,biological_process cell differentiation involved in kidney development;GO:0070242,biological_process thymocyte apoptotic process;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:1903010,biological_process regulation of bone development	GLI3; zinc finger protein GLI3; K06230	GLI family zinc finger 3 [Source:HGNC Symbol%3BAcc:HGNC:4319]
ENSG00000135720	67.12	72.09	72.29	73.19	76.09	74.97	-0.0736787966581628	6.77965314722869	0.256805809606984	0.639760094671768	16:66720892-66751798:-	DYNC1LI2	20;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007018,biological_process microtubule-based movement;GO:0007062,biological_process sister chromatid cohesion;GO:0016020,cellular_component membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030286,cellular_component dynein complex;GO:0045504,molecular_function dynein heavy chain binding;GO:0051642,biological_process centrosome localization	DYNC1LI, DNCLI; dynein light intermediate chain 1, cytosolic; K10416	dynein cytoplasmic 1 light intermediate chain 2 [Source:HGNC Symbol%3BAcc:HGNC:2966]
ENSG00000182890	0.89	0.23	1.01	0.27	0.72	0.50	0.563017143051738	0.250532152709888	0.256835152902501	0.639760094671768	X:121047587-121050080:+	GLUD2	12;GO:0004352,molecular_function glutamate dehydrogenase (NAD+) activity;GO:0004353,molecular_function glutamate dehydrogenase [NAD(P)+] activity;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006537,biological_process glutamate biosynthetic process;GO:0006538,biological_process glutamate catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0043531,molecular_function ADP binding;GO:0055114,biological_process oxidation-reduction process;GO:0070728,molecular_function leucine binding	GLUD1_2, gdhA; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]; K00261	glutamate dehydrogenase 2 [Source:HGNC Symbol%3BAcc:HGNC:4336]
ENSG00000198522	35.40	36.41	33.68	38.25	37.46	36.55	-0.0800660761650517	5.49604480427889	0.256856378407706	0.639760094671768	2:27628246-27651508:+	GPN1	12;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016787,molecular_function hydrolase activity;GO:0044376,biological_process RNA polymerase II complex import to nucleus;GO:1990022,biological_process RNA polymerase III complex localization to nucleus	NA	GPN-loop GTPase 1 [Source:HGNC Symbol%3BAcc:HGNC:17030]
ENSG00000104320	45.40	45.23	44.84	45.88	50.06	47.72	-0.0728375971004696	6.72243506779957	0.256872980894553	0.639760094671768	8:89933335-90003228:-	NBN	50;GO:0000077,biological_process DNA damage checkpoint;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001701,biological_process in utero embryonic development;GO:0001832,biological_process blastocyst growth;GO:0003684,molecular_function damaged DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0016605,cellular_component PML body;GO:0030174,biological_process regulation of DNA-dependent DNA replication initiation;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0030870,cellular_component Mre11 complex;GO:0031860,biological_process telomeric 3' overhang formation;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0032508,biological_process DNA duplex unwinding;GO:0033674,biological_process positive regulation of kinase activity;GO:0035861,cellular_component site of double-strand break;GO:0042405,cellular_component nuclear inclusion body;GO:0045190,biological_process isotype switching;GO:0047485,molecular_function protein N-terminus binding;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051321,biological_process meiotic cell cycle;GO:0090656,biological_process t-circle formation;GO:0090737,biological_process telomere maintenance via telomere trimming;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904354,biological_process negative regulation of telomere capping	NBN, NBS1; nibrin; K10867	nibrin [Source:HGNC Symbol%3BAcc:HGNC:7652]
ENSG00000171848	11.27	14.77	9.87	13.48	14.26	12.30	-0.156108194007219	4.12410030413976	0.257012587422169	0.63997938769737	2:10120697-10131419:+	RRM2	12;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0004748,molecular_function ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005971,cellular_component ribonucleoside-diphosphate reductase complex;GO:0006260,biological_process DNA replication;GO:0009263,biological_process deoxyribonucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]; K10808	ribonucleotide reductase regulatory subunit M2 [Source:HGNC Symbol%3BAcc:HGNC:10452]
ENSG00000087338	24.64	23.94	24.77	22.15	25.04	22.53	0.0870993756608412	5.20970398736346	0.257222189383786	0.640372851347961	2:69829641-69881396:+	GMCL1	10;GO:0000151,cellular_component ubiquitin ligase complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016363,cellular_component nuclear matrix;GO:0030154,biological_process cell differentiation;GO:0042802,molecular_function identical protein binding	NA	germ cell-less%2C spermatogenesis associated 1 [Source:HGNC Symbol%3BAcc:HGNC:23843]
ENSG00000105679	7.96	6.95	6.86	7.65	5.45	6.43	0.171289832215626	3.10215985969176	0.257300701163292	0.640439864355312	19:35533411-35545316:+	GAPDHS	16;GO:0004365,molecular_function glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006006,biological_process glucose metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016620,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0030317,biological_process sperm motility;GO:0045821,biological_process positive regulation of glycolytic process;GO:0050661,molecular_function NADP binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0061621,biological_process canonical glycolysis	GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [EC:1.2.1.12]; K10705	glyceraldehyde-3-phosphate dehydrogenase%2C spermatogenic [Source:HGNC Symbol%3BAcc:HGNC:24864]
ENSG00000121879	10.57	10.55	9.69	9.18	9.89	10.11	0.0882888323041682	5.00908750408499	0.257401904588388	0.640563320299852	3:179148113-179240093:+	PIK3CA	67;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001889,biological_process liver development;GO:0001944,biological_process vasculature development;GO:0002250,biological_process adaptive immune response;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005942,cellular_component phosphatidylinositol 3-kinase complex;GO:0005943,cellular_component phosphatidylinositol 3-kinase complex, class IA;GO:0006006,biological_process glucose metabolic process;GO:0006468,biological_process protein phosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006909,biological_process phagocytosis;GO:0006954,biological_process inflammatory response;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0010468,biological_process regulation of gene expression;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030027,cellular_component lamellipodium;GO:0030168,biological_process platelet activation;GO:0030295,molecular_function protein kinase activator activity;GO:0031295,biological_process T cell costimulation;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032147,biological_process activation of protein kinase activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035004,molecular_function phosphatidylinositol 3-kinase activity;GO:0035005,molecular_function 1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038028,biological_process insulin receptor signaling pathway via phosphatidylinositol 3-kinase;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0040014,biological_process regulation of multicellular organism growth;GO:0043276,biological_process anoikis;GO:0043457,biological_process regulation of cellular respiration;GO:0043491,biological_process protein kinase B signaling;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043542,biological_process endothelial cell migration;GO:0043560,molecular_function insulin receptor substrate binding;GO:0044029,biological_process hypomethylation of CpG island;GO:0045087,biological_process innate immune response;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0060048,biological_process cardiac muscle contraction;GO:0060326,biological_process cell chemotaxis;GO:0060612,biological_process adipose tissue development;GO:0071333,biological_process cellular response to glucose stimulus;GO:0097009,biological_process energy homeostasis;GO:2000270,biological_process negative regulation of fibroblast apoptotic process;GO:2000653,biological_process regulation of genetic imprinting;GO:2000811,biological_process negative regulation of anoikis	PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]; K00922	phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:8975]
ENSG00000065978	943.86	1046.48	956.27	1028.59	1074.20	1020.21	-0.0721914276749287	10.4174690323938	0.257481362100394	0.640632621317337	1:42682426-42702349:+	YBX1	37;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010494,cellular_component cytoplasmic stress granule;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031965,cellular_component nuclear membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051020,molecular_function GTPase binding;GO:0051154,biological_process negative regulation of striated muscle cell differentiation;GO:0051781,biological_process positive regulation of cell division;GO:0070062,cellular_component extracellular exosome;GO:0070934,biological_process CRD-mediated mRNA stabilization;GO:0070937,cellular_component CRD-mediated mRNA stability complex;GO:0071204,cellular_component histone pre-mRNA 3'end processing complex;GO:1903608,biological_process protein localization to cytoplasmic stress granule	NA	Y-box binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8014]
ENSG00000074356	27.58	25.23	28.04	28.23	26.42	32.26	-0.0906491362201334	5.80659277032657	0.257654837757857	0.640935771761178	17:3802164-3846251:-	NCBP3	14;GO:0000339,molecular_function RNA cap binding;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006397,biological_process mRNA processing;GO:0006810,biological_process transport;GO:0016607,cellular_component nuclear speck;GO:0034518,cellular_component RNA cap binding complex;GO:0051028,biological_process mRNA transport;GO:0051607,biological_process defense response to virus	NA	nuclear cap binding subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:24612]
ENSG00000167107	19.85	19.84	20.18	20.60	23.78	19.94	-0.0906592470966956	5.39775977481264	0.257805936499025	0.641183147618193	17:50426157-50474845:+	ACSF2	12;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003996,molecular_function acyl-CoA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008152,biological_process metabolic process;GO:0016874,molecular_function ligase activity	NA	acyl-CoA synthetase family member 2 [Source:HGNC Symbol%3BAcc:HGNC:26101]
ENSG00000122034	37.48	37.96	31.06	31.41	33.83	34.98	0.0961297660389049	5.38113196857919	0.257922620182205	0.641344848622137	13:27424543-27435823:+	GTF3A	13;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008097,molecular_function 5S rRNA binding;GO:0009303,biological_process rRNA transcription;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0046872,molecular_function metal ion binding	NA	general transcription factor IIIA [Source:HGNC Symbol%3BAcc:HGNC:4662]
ENSG00000065809	49.45	48.38	49.53	42.77	51.60	45.33	0.09006022515651	5.51765979482219	0.257985415475419	0.641372513978846	10:14518556-14774897:-	FAM107B	NA	NA	family with sequence similarity 107 member B [Source:HGNC Symbol%3BAcc:HGNC:23726]
ENSG00000265241	136.52	142.98	143.82	150.89	147.18	150.20	-0.0718485248063455	6.24844438928432	0.258141185949279	0.64154516498761	1:145917713-145927678:-	RBM8A	27;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0030425,cellular_component dendrite;GO:0031124,biological_process mRNA 3'-end processing;GO:0035145,cellular_component exon-exon junction complex;GO:0043025,cellular_component neuronal cell body;GO:0051028,biological_process mRNA transport;GO:0071013,cellular_component catalytic step 2 spliceosome	RBM8A, Y14; RNA-binding protein 8A; K12876	RNA binding motif protein 8A [Source:HGNC Symbol%3BAcc:HGNC:9905]
ENSG00000072778	198.93	192.50	210.71	195.31	184.36	198.45	0.0707711507751309	8.83067528642161	0.258158229204311	0.64154516498761	17:7217124-7225273:+	ACADVL	28;GO:0001659,biological_process temperature homeostasis;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0004466,molecular_function long-chain-acyl-CoA dehydrogenase activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0009062,biological_process fatty acid catabolic process;GO:0009409,biological_process response to cold;GO:0015980,biological_process energy derivation by oxidation of organic compounds;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0030855,biological_process epithelial cell differentiation;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042645,cellular_component mitochondrial nucleoid;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0046322,biological_process negative regulation of fatty acid oxidation;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0090181,biological_process regulation of cholesterol metabolic process	ACADVL; very long chain acyl-CoA dehydrogenase [EC:1.3.8.9]; K09479	acyl-CoA dehydrogenase%2C very long chain [Source:HGNC Symbol%3BAcc:HGNC:92]
ENSG00000076201	13.08	14.19	13.65	12.54	13.20	13.40	0.0738033115548192	6.03626499921656	0.258410350907043	0.64191986184938	3:47381010-47413441:+	PTPN23	35;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006470,biological_process protein dephosphorylation;GO:0006810,biological_process transport;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0015031,biological_process protein transport;GO:0016311,biological_process dephosphorylation;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0030030,biological_process cell projection organization;GO:0030334,biological_process regulation of cell migration;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032456,biological_process endocytic recycling;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0045022,biological_process early endosome to late endosome transport;GO:0060271,biological_process cilium morphogenesis;GO:0061357,biological_process positive regulation of Wnt protein secretion;GO:0070062,cellular_component extracellular exosome;GO:1903387,biological_process positive regulation of homophilic cell adhesion;GO:1903393,biological_process positive regulation of adherens junction organization;GO:2000643,biological_process positive regulation of early endosome to late endosome transport	NA	protein tyrosine phosphatase%2C non-receptor type 23 [Source:HGNC Symbol%3BAcc:HGNC:14406]
ENSG00000168566	14.33	17.16	14.58	14.32	11.76	15.92	0.135425327638178	3.92135151206699	0.258412434517148	0.64191986184938	6:7590198-7611967:+	SNRNP48	10;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0046872,molecular_function metal ion binding	NA	small nuclear ribonucleoprotein U11/U12 subunit 48 [Source:HGNC Symbol%3BAcc:HGNC:21368]
ENSG00000156467	399.66	396.95	385.25	379.95	390.98	365.70	0.0679929829950776	8.04571712715448	0.258528801009359	0.642037708051703	8:96225919-96235634:-	UQCRB	14;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006119,biological_process oxidative phosphorylation;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7; K00417	ubiquinol-cytochrome c reductase binding protein [Source:HGNC Symbol%3BAcc:HGNC:12582]
ENSG00000105063	35.33	38.47	36.76	35.33	34.18	36.26	0.0738492249627527	6.57670103952913	0.258563320917624	0.642037708051703	19:55229779-55258995:-	PPP6R1	7;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0019903,molecular_function protein phosphatase binding;GO:0043666,biological_process regulation of phosphoprotein phosphatase activity;GO:0048208,biological_process COPII vesicle coating	NA	protein phosphatase 6 regulatory subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:29195]
ENSG00000173530	8.84	8.17	12.65	11.44	10.94	11.29	-0.162959138549224	3.63804241734738	0.258639163877525	0.642097588242344	8:23135587-23164030:-	TNFRSF10D	20;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045569,molecular_function TRAIL binding;GO:0050900,biological_process leukocyte migration;GO:0097190,biological_process apoptotic signaling pathway	TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B; K04722	TNF receptor superfamily member 10d [Source:HGNC Symbol%3BAcc:HGNC:11907]
ENSG00000158805	8.85	7.73	9.19	9.87	8.44	10.00	-0.117644431317264	4.0732396636465	0.258751991322508	0.642249243808496	16:89720399-89740903:+	ZNF276	12;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 276 [Source:HGNC Symbol%3BAcc:HGNC:23330]
ENSG00000198853	12.55	11.62	11.93	11.66	10.79	12.03	0.079377908024737	5.74686359035726	0.258911545876947	0.642516797075278	9:35490126-35561898:+	RUSC2	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0017137,molecular_function Rab GTPase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0070062,cellular_component extracellular exosome	NA	RUN and SH3 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:23625]
ENSG00000167106	24.34	23.39	23.83	23.59	20.41	23.50	0.0964390434230826	4.74817449740496	0.258970928228658	0.642535704997468	9:127940578-127980513:-	FAM102A	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 102 member A [Source:HGNC Symbol%3BAcc:HGNC:31419]
ENSG00000197619	6.27	4.51	5.64	5.19	4.93	4.93	0.151167143703454	3.62374656794509	0.259083838170671	0.642594940102217	19:51991331-52008230:-	ZNF615	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 615 [Source:HGNC Symbol%3BAcc:HGNC:24740]
ENSG00000138092	15.60	14.83	10.47	15.97	15.77	14.25	-0.160509869604983	3.76395764577789	0.259121170637433	0.642594940102217	2:24793135-24822376:+	CENPO	11;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0034508,biological_process centromere complex assembly	NA	centromere protein O [Source:HGNC Symbol%3BAcc:HGNC:28152]
ENSG00000213928	32.78	32.40	33.95	35.55	33.18	36.83	-0.0786862820597631	5.57597987157044	0.259268923066418	0.642594940102217	14:24161052-24166565:+	IRF9	16;GO:0000975,molecular_function regulatory region DNA binding;GO:0001047,molecular_function core promoter binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway	IRF9, ISGF3G, P48; interferon regulatory factor 9; K04693	interferon regulatory factor 9 [Source:HGNC Symbol%3BAcc:HGNC:6131]
ENSG00000060339	30.45	28.27	32.56	30.46	32.47	34.52	-0.0812531044958603	6.87004167737829	0.259269150449168	0.642594940102217	10:68721011-68792377:+	CCAR1	17;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001047,molecular_function core promoter binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0030335,biological_process positive regulation of cell migration;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	cell division cycle and apoptosis regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:24236]
ENSG00000123933	18.67	19.47	18.10	13.30	19.23	18.74	0.142395321296273	4.05937688927085	0.259386549253023	0.642594940102217	4:2247431-2262294:-	MXD4	9;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008285,biological_process negative regulation of cell proliferation;GO:0046983,molecular_function protein dimerization activity	NA	MAX dimerization protein 4 [Source:HGNC Symbol%3BAcc:HGNC:13906]
ENSG00000162076	33.98	33.36	38.19	35.74	28.76	33.43	0.12156500584095	4.18166809340506	0.259518863436489	0.642594940102217	16:2883185-2899382:+	FLYWCH2	3;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	FLYWCH family member 2 [Source:HGNC Symbol%3BAcc:HGNC:25178]
ENSG00000109475	822.56	786.85	766.42	864.97	806.39	841.61	-0.0691554206857963	8.1615950282887	0.259526570219648	0.642594940102217	4:108620565-108630412:+	RPL34	17;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042254,biological_process ribosome biogenesis;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein L34 [Source:HGNC Symbol%3BAcc:HGNC:10340]
ENSG00000168569	16.78	16.04	16.33	19.81	16.29	18.20	-0.130568684460617	3.62089459140527	0.259614353835835	0.642594940102217	11:62771628-62792021:-	TMEM223	4;GO:0005739,cellular_component mitochondrion;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 223 [Source:HGNC Symbol%3BAcc:HGNC:28464]
ENSG00000108469	13.79	14.23	14.74	14.90	15.42	15.12	-0.076119948598406	5.58439872060628	0.259648267708348	0.642594940102217	17:75626844-75667189:-	RECQL5	33;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006259,biological_process DNA metabolic process;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0009378,molecular_function four-way junction helicase activity;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0035690,biological_process cellular response to drug;GO:0043140,molecular_function ATP-dependent 3'-5' DNA helicase activity;GO:0051301,biological_process cell division;GO:0051304,biological_process chromosome separation;GO:0072757,biological_process cellular response to camptothecin;GO:1990414,biological_process replication-born double-strand break repair via sister chromatid exchange;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination	NA	RecQ like helicase 5 [Source:HGNC Symbol%3BAcc:HGNC:9950]
ENSG00000168763	5.76	6.80	6.66	6.11	5.94	5.67	0.124303290778554	3.71941943503878	0.259658560018408	0.642594940102217	2:96816244-96833911:+	CNNM3	6;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	cyclin and CBS domain divalent metal cation transport mediator 3 [Source:HGNC Symbol%3BAcc:HGNC:104]
ENSG00000107821	6.51	5.97	5.57	6.32	7.32	6.94	-0.175450747776315	2.59435482697189	0.259700678418106	0.642594940102217	10:101061840-101068131:+	KAZALD1	9;GO:0001503,biological_process ossification;GO:0001558,biological_process regulation of cell growth;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005614,cellular_component interstitial matrix;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0030198,biological_process extracellular matrix organization	NA	Kazal type serine peptidase inhibitor domain 1 [Source:HGNC Symbol%3BAcc:HGNC:25460]
ENSG00000162980	36.62	39.47	35.98	43.12	38.34	39.72	-0.105711374975717	4.4019721813263	0.259788952093557	0.642594940102217	2:151788983-151828492:-	ARL5A	4;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction	NA	ADP ribosylation factor like GTPase 5A [Source:HGNC Symbol%3BAcc:HGNC:696]
ENSG00000071189	22.54	23.94	24.09	19.37	23.98	23.43	0.0906497989799053	6.13273112695883	0.259829424660887	0.642594940102217	7:17790760-17940501:-	SNX13	13;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008289,molecular_function lipid binding;GO:0009968,biological_process negative regulation of signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031901,cellular_component early endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043547,biological_process positive regulation of GTPase activity	NA	sorting nexin 13 [Source:HGNC Symbol%3BAcc:HGNC:21335]
ENSG00000247595	3.25	2.20	3.15	3.45	3.49	4.86	-0.420355622201578	0.26617132978832	0.259923325787233	0.642594940102217	11:18588780-18610255:+	SPTY2D1-AS1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	SPTY2D1 antisense RNA 1 [Source:HGNC Symbol%3BAcc:HGNC:44122]
ENSG00000196118	4.54	4.25	5.85	4.34	4.10	4.52	0.195639647715092	2.57611092655329	0.259947380244863	0.642594940102217	16:30757422-30762710:-	CCDC189	NA	NA	coiled-coil domain containing 189 [Source:HGNC Symbol%3BAcc:HGNC:28078]
ENSG00000170439	2.13	3.35	4.98	4.88	4.40	3.74	-0.302790426228904	1.76345796805706	0.259952402145082	0.642594940102217	12:55681545-55684611:+	METTL7B	4;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	methyltransferase like 7B [Source:HGNC Symbol%3BAcc:HGNC:28276]
ENSG00000165572	2.72	2.41	2.73	1.78	2.85	2.19	0.225379762513219	2.35188342559613	0.259968519099518	0.642594940102217	13:41127568-41132746:-	KBTBD6	9;GO:0003674,molecular_function molecular_function;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification	NA	kelch repeat and BTB domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:25340]
ENSG00000127337	20.56	21.04	18.31	21.42	21.98	21.69	-0.112277173757958	4.07912002296341	0.260028061861189	0.642594940102217	12:69359702-69390796:+	YEATS4	20;GO:0000278,biological_process mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007010,biological_process cytoskeleton organization;GO:0008022,molecular_function protein C-terminus binding;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0031965,cellular_component nuclear membrane;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	YEATS domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:24859]
ENSG00000175324	41.42	39.28	34.15	40.14	31.90	33.47	0.133449716671151	3.94644121858075	0.260029906416607	0.642594940102217	8:38163320-38176730:-	LSM1	25;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000339,molecular_function RNA cap binding;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005845,cellular_component mRNA cap binding complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0019827,biological_process stem cell population maintenance;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0036002,molecular_function pre-mRNA binding;GO:0043025,cellular_component neuronal cell body;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0071044,biological_process histone mRNA catabolic process;GO:1990124,cellular_component messenger ribonucleoprotein complex;GO:1990726,cellular_component Lsm1-7-Pat1 complex	LSM1; U6 snRNA-associated Sm-like protein LSm1; K12620	LSM1 homolog%2C mRNA degradation associated [Source:HGNC Symbol%3BAcc:HGNC:20472]
ENSG00000126775	10.81	13.92	13.46	13.44	13.82	14.48	-0.12439912551151	4.30719013890201	0.26003016064879	0.642594940102217	14:55366391-55411858:-	ATG14	34;GO:0000045,biological_process autophagosome assembly;GO:0000421,cellular_component autophagosome membrane;GO:0000423,biological_process macromitophagy;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006914,biological_process autophagy;GO:0008333,biological_process endosome to lysosome transport;GO:0009267,biological_process cellular response to starvation;GO:0010508,biological_process positive regulation of autophagy;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0016240,biological_process autophagosome docking;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0035032,cellular_component phosphatidylinositol 3-kinase complex, class III;GO:0042149,biological_process cellular response to glucose starvation;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0045335,cellular_component phagocytic vesicle;GO:0051020,molecular_function GTPase binding;GO:0061635,biological_process regulation of protein complex stability;GO:0090207,biological_process regulation of triglyceride metabolic process;GO:0097629,cellular_component extrinsic component of omegasome membrane;GO:0097632,cellular_component extrinsic component of pre-autophagosomal structure membrane;GO:0098780,biological_process response to mitochondrial depolarisation	NA	autophagy related 14 [Source:HGNC Symbol%3BAcc:HGNC:19962]
ENSG00000137492	26.39	21.31	24.25	22.92	22.46	22.95	0.0909892787212951	5.76203524021477	0.260158178114305	0.642783332988229	11:76349955-76380971:-	THAP12	13;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006950,biological_process response to stress;GO:0007165,biological_process signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity	NA	THAP domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:9440]
ENSG00000173218	12.36	12.04	11.38	12.34	14.23	12.35	-0.109052087966017	4.30261195144444	0.260421354195168	0.643305526293457	1:115641952-115698224:+	VANGL1	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0043473,biological_process pigmentation;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway	VANGL; vang-like; K04510	VANGL planar cell polarity protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15512]
ENSG00000143457	17.41	19.30	15.74	19.67	19.10	18.40	-0.12045387700179	4.08373850036895	0.260547888891526	0.643490040750202	1:150646224-150697144:-	GOLPH3L	16;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0031985,cellular_component Golgi cisterna;GO:0032580,cellular_component Golgi cisterna membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0048194,biological_process Golgi vesicle budding;GO:0050714,biological_process positive regulation of protein secretion;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	golgi phosphoprotein 3 like [Source:HGNC Symbol%3BAcc:HGNC:24882]
ENSG00000168792	7.50	9.05	8.02	7.47	8.26	6.56	0.145582880292412	3.46733324949872	0.260670127099958	0.643529895155185	17:29560546-29567137:-	ABHD15	5;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0044255,biological_process cellular lipid metabolic process	NA	abhydrolase domain containing 15 [Source:HGNC Symbol%3BAcc:HGNC:26971]
ENSG00000099968	42.09	42.08	40.30	44.90	41.11	46.25	-0.0769075547946377	6.14677631434407	0.260673492819611	0.643529895155185	22:17628854-17730855:+	BCL2L13	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0042981,biological_process regulation of apoptotic process	BCL2L13, BCL-RAMBO; Bcl-2-like protein 13; K15485	BCL2 like 13 [Source:HGNC Symbol%3BAcc:HGNC:17164]
ENSG00000255072	142.91	163.31	152.73	180.33	148.48	166.39	-0.102371081407194	5.088231061698	0.26071955552529	0.643529895155185	4:88521572-88521789:-	PIGY	7;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	PIGY; phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; K11001	phosphatidylinositol glycan anchor biosynthesis class Y [Source:HGNC Symbol%3BAcc:HGNC:28213]
ENSG00000159423	7.97	9.77	8.52	7.52	8.29	8.35	0.121425016875638	3.84773130585156	0.260892104327957	0.643827771575135	1:18871429-18902781:-	ALDH4A1	14;GO:0003842,molecular_function 1-pyrroline-5-carboxylate dehydrogenase activity;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006560,biological_process proline metabolic process;GO:0006562,biological_process proline catabolic process;GO:0008152,biological_process metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0010133,biological_process proline catabolic process to glutamate;GO:0016491,molecular_function oxidoreductase activity;GO:0019470,biological_process 4-hydroxyproline catabolic process;GO:0042802,molecular_function identical protein binding;GO:0046487,biological_process glyoxylate metabolic process;GO:0055114,biological_process oxidation-reduction process	E1.2.1.88; 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]; K00294	aldehyde dehydrogenase 4 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:406]
ENSG00000187522	14.83	13.78	12.89	12.52	13.67	12.87	0.100590265530986	4.58499604540225	0.261221608278474	0.644508897351359	10:14838163-14871741:+	HSPA14	8;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0016020,cellular_component membrane;GO:0051083,biological_process 'de novo' cotranslational protein folding	NA	heat shock protein family A (Hsp70) member 14 [Source:HGNC Symbol%3BAcc:HGNC:29526]
ENSG00000185513	3.80	3.22	3.75	4.02	3.89	4.03	-0.127556133655407	3.45645784272606	0.261271954521231	0.644508897351359	20:43507679-43550950:+	L3MBTL1	26;GO:0000785,cellular_component chromatin;GO:0000793,cellular_component condensed chromosome;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0030097,biological_process hemopoiesis;GO:0031491,molecular_function nucleosome binding;GO:0031493,molecular_function nucleosomal histone binding;GO:0032093,molecular_function SAM domain binding;GO:0035064,molecular_function methylated histone binding;GO:0042393,molecular_function histone binding;GO:0042802,molecular_function identical protein binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	L3MBTL1%2C histone methyl-lysine binding protein [Source:HGNC Symbol%3BAcc:HGNC:15905]
ENSG00000115286	31.58	30.70	32.68	27.97	31.81	30.17	0.0920897529684783	4.86035595135598	0.262021370026926	0.646229140898913	19:1383526-1395589:+	NDUFS7	21;GO:0002020,molecular_function protease binding;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005759,cellular_component mitochondrial matrix;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016655,molecular_function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0046872,molecular_function metal ion binding;GO:0048038,molecular_function quinone binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:0097060,cellular_component synaptic membrane	NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2 1.6.99.3]; K03940	NADH:ubiquinone oxidoreductase core subunit S7 [Source:HGNC Symbol%3BAcc:HGNC:7714]
ENSG00000069509	32.50	34.73	29.76	32.20	29.36	28.13	0.119679690996678	3.86600948195659	0.262417648753093	0.646696589002686	X:44523638-44543001:-	FUNDC1	11;GO:0000422,biological_process mitophagy;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006914,biological_process autophagy;GO:0010243,biological_process response to organonitrogen compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0031307,cellular_component integral component of mitochondrial outer membrane	NA	FUN14 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28746]
ENSG00000216937	0.54	0.51	0.44	0.36	0.44	0.42	0.291238806396381	1.07257226746768	0.262432346830523	0.646696589002686	10:32446139-32882874:+	CCDC7	NA	NA	coiled-coil domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:26533]
ENSG00000181915	13.51	12.39	12.27	11.18	10.77	12.94	0.141712506133065	3.32602857054337	0.262439131207608	0.646696589002686	10:62804856-62808483:+	ADO	9;GO:0000098,biological_process sulfur amino acid catabolic process;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0046872,molecular_function metal ion binding;GO:0047800,molecular_function cysteamine dioxygenase activity;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	ADO; cysteamine dioxygenase [EC:1.13.11.19]; K10712	2-aminoethanethiol dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:23506]
ENSG00000136754	44.80	45.57	48.93	49.91	46.56	51.66	-0.0769315458969482	6.24187246887963	0.262452567875209	0.646696589002686	10:26746592-26861087:-	ABI1	39;GO:0001756,biological_process somitogenesis;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008154,biological_process actin polymerization or depolymerization;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0017124,molecular_function SH3 domain binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030296,molecular_function protein tyrosine kinase activator activity;GO:0030426,cellular_component growth cone;GO:0031209,cellular_component SCAR complex;GO:0031252,cellular_component cell leading edge;GO:0032403,molecular_function protein complex binding;GO:0035855,biological_process megakaryocyte development;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045296,molecular_function cadherin binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048813,biological_process dendrite morphogenesis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0072673,biological_process lamellipodium morphogenesis	NA	abl interactor 1 [Source:HGNC Symbol%3BAcc:HGNC:11320]
ENSG00000198873	3.91	3.13	3.99	2.92	2.96	3.89	0.195277728867208	2.6611870068125	0.262513103976867	0.646696589002686	10:119207588-119459742:+	GRK5	32;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004703,molecular_function G-protein coupled receptor kinase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007217,biological_process tachykinin receptor signaling pathway;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031965,cellular_component nuclear membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045444,biological_process fat cell differentiation;GO:0046777,biological_process protein autophosphorylation;GO:0047696,molecular_function beta-adrenergic receptor kinase activity;GO:0051726,biological_process regulation of cell cycle	GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]; K08291	G protein-coupled receptor kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:4544]
ENSG00000182810	6.10	6.61	6.09	7.12	7.02	6.60	-0.134426560887751	3.43594161833802	0.262573538408293	0.646696589002686	16:68021273-68023442:-	DDX28	18;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016787,molecular_function hydrolase activity;GO:0019843,molecular_function rRNA binding;GO:0035770,cellular_component ribonucleoprotein granule;GO:0042254,biological_process ribosome biogenesis;GO:0042645,cellular_component mitochondrial nucleoid;GO:1902775,biological_process mitochondrial large ribosomal subunit assembly	NA	DEAD-box helicase 28 [Source:HGNC Symbol%3BAcc:HGNC:17330]
ENSG00000168101	12.58	14.14	12.27	9.90	14.06	11.28	0.152455596709127	3.58278513825529	0.262575590797836	0.646696589002686	16:4693693-4695859:+	NUDT16L1	6;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016787,molecular_function hydrolase activity;GO:0030515,molecular_function snoRNA binding;GO:2001033,biological_process negative regulation of double-strand break repair via nonhomologous end joining	NUDT16L1, SDOS; NUDT16-like protein 1; K16867	nudix hydrolase 16 like 1 [Source:HGNC Symbol%3BAcc:HGNC:28154]
ENSG00000249992	3.53	3.50	2.86	2.91	2.44	2.97	0.253088598022132	1.52425744056547	0.262823046873578	0.647177639524246	3:45224465-45226278:-	TMEM158	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042277,molecular_function peptide binding	NA	transmembrane protein 158 (gene/pseudogene) [Source:HGNC Symbol%3BAcc:HGNC:30293]
ENSG00000198001	12.17	13.49	13.86	12.36	11.31	13.14	0.109833883176194	4.14650980622732	0.262911901113396	0.647268034216696	12:43758943-43789543:+	IRAK4	33;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001816,biological_process cytokine production;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002446,biological_process neutrophil mediated immunity;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005149,molecular_function interleukin-1 receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007254,biological_process JNK cascade;GO:0010008,cellular_component endosome membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:1990266,biological_process neutrophil migration	IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]; K04733	interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:17967]
ENSG00000128989	73.50	75.63	71.54	70.68	68.70	69.96	0.0852311155077976	4.82301613720499	0.26303939653217	0.647453505681902	15:52547044-52569883:-	ARPP19	20;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0015459,molecular_function potassium channel regulator activity;GO:0019212,molecular_function phosphatase inhibitor activity;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0035308,biological_process negative regulation of protein dephosphorylation;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045722,biological_process positive regulation of gluconeogenesis;GO:0046326,biological_process positive regulation of glucose import;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0050790,biological_process regulation of catalytic activity;GO:0051301,biological_process cell division;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0065009,biological_process regulation of molecular function	NA	cAMP regulated phosphoprotein 19 [Source:HGNC Symbol%3BAcc:HGNC:16967]
ENSG00000012963	18.39	19.11	18.07	17.85	15.58	18.64	0.101455142549982	4.52480470426898	0.26319209344532	0.647512328945921	14:93207055-93229215:+	UBR7	6;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	ubiquitin protein ligase E3 component n-recognin 7 (putative) [Source:HGNC Symbol%3BAcc:HGNC:20344]
ENSG00000135486	781.56	844.14	720.45	798.59	880.65	821.28	-0.080297870587601	9.91219206574695	0.263216529636868	0.647512328945921	12:54280192-54287088:+	HNRNPA1	34;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016070,biological_process RNA metabolic process;GO:0019013,cellular_component viral nucleocapsid;GO:0019904,molecular_function protein domain specific binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0036002,molecular_function pre-mRNA binding;GO:0042149,biological_process cellular response to glucose starvation;GO:0051028,biological_process mRNA transport;GO:0051168,biological_process nuclear export;GO:0051170,biological_process nuclear import;GO:0061752,molecular_function telomeric repeat-containing RNA binding;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1903936,biological_process cellular response to sodium arsenite	HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3; K12741	heterogeneous nuclear ribonucleoprotein A1 [Source:HGNC Symbol%3BAcc:HGNC:5031]
ENSG00000035928	30.62	28.25	31.28	31.39	31.50	32.78	-0.0723437126438097	6.7713172669518	0.263290905200714	0.647512328945921	4:39287455-39366375:-	RFC1	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0003690,molecular_function double-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005663,cellular_component DNA replication factor C complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007004,biological_process telomere maintenance via telomerase;GO:0008047,molecular_function enzyme activator activity;GO:0019904,molecular_function protein domain specific binding;GO:0019985,biological_process translesion synthesis;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0070062,cellular_component extracellular exosome;GO:0070987,biological_process error-free translesion synthesis	RFC1; replication factor C subunit 1; K10754	replication factor C subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:9969]
ENSG00000100347	34.08	38.99	33.16	38.21	38.22	36.98	-0.0874440064251209	5.69000246272863	0.263349917185039	0.647512328945921	22:43955420-44010531:+	SAMM50	13;GO:0001401,cellular_component mitochondrial sorting and assembly machinery complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019867,cellular_component outer membrane;GO:0033108,biological_process mitochondrial respiratory chain complex assembly;GO:0042407,biological_process cristae formation;GO:0045040,biological_process protein import into mitochondrial outer membrane;GO:0070062,cellular_component extracellular exosome	NA	SAMM50 sorting and assembly machinery component [Source:HGNC Symbol%3BAcc:HGNC:24276]
ENSG00000117505	76.91	64.98	65.38	76.72	70.96	75.38	-0.0903691616349657	5.25202734092642	0.263353067758138	0.647512328945921	1:93345887-93369498:+	DR1	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0017025,molecular_function TBP-class protein binding;GO:0043966,biological_process histone H3 acetylation;GO:0046982,molecular_function protein heterodimerization activity	NA	down-regulator of transcription 1 [Source:HGNC Symbol%3BAcc:HGNC:3017]
ENSG00000112561	7.94	8.79	7.72	7.81	7.82	6.96	0.120618573787959	3.75401295011504	0.263376278808342	0.647512328945921	6:41683977-41736259:-	TFEB	18;GO:0001892,biological_process embryonic placenta development;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006914,biological_process autophagy;GO:0006959,biological_process humoral immune response;GO:0007040,biological_process lysosome organization;GO:0010508,biological_process positive regulation of autophagy;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity	TFEB; transcription factor EB; K15590	transcription factor EB [Source:HGNC Symbol%3BAcc:HGNC:11753]
ENSG00000101189	39.35	42.32	43.05	41.84	42.88	50.21	-0.104930035449293	4.73702216084035	0.263463984799134	0.647592890625828	20:62796452-62801738:+	MRGBP	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043189,cellular_component H4/H2A histone acetyltransferase complex	NA	MRG domain binding protein [Source:HGNC Symbol%3BAcc:HGNC:15866]
ENSG00000143951	2.72	2.75	3.39	3.48	3.40	3.12	-0.157403399256495	2.92770766093401	0.26351338842754	0.647592890625828	2:63121382-63827843:-	WDPCP	33;GO:0001822,biological_process kidney development;GO:0002093,biological_process auditory receptor cell morphogenesis;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0005938,cellular_component cell cortex;GO:0007224,biological_process smoothened signaling pathway;GO:0007399,biological_process nervous system development;GO:0010762,biological_process regulation of fibroblast migration;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016476,biological_process regulation of embryonic cell shape;GO:0030030,biological_process cell projection organization;GO:0032185,biological_process septin cytoskeleton organization;GO:0032880,biological_process regulation of protein localization;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0044782,biological_process cilium organization;GO:0045184,biological_process establishment of protein localization;GO:0048568,biological_process embryonic organ development;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0055123,biological_process digestive system development;GO:0060021,biological_process palate development;GO:0060271,biological_process cilium morphogenesis;GO:0060541,biological_process respiratory system development;GO:0072358,biological_process cardiovascular system development;GO:0090521,biological_process glomerular visceral epithelial cell migration;GO:0097541,cellular_component axonemal basal plate;GO:1900027,biological_process regulation of ruffle assembly;GO:2000114,biological_process regulation of establishment of cell polarity	NA	WD repeat containing planar cell polarity effector [Source:HGNC Symbol%3BAcc:HGNC:28027]
ENSG00000128791	65.23	69.10	65.57	69.36	71.39	71.28	-0.0758861096448315	5.65794829514856	0.263869965215014	0.648340831000389	18:9334766-9402420:+	TWSG1	23;GO:0001503,biological_process ossification;GO:0001707,biological_process mesoderm formation;GO:0001818,biological_process negative regulation of cytokine production;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007435,biological_process salivary gland morphogenesis;GO:0009888,biological_process tissue development;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030900,biological_process forebrain development;GO:0043010,biological_process camera-type eye development;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0050431,molecular_function transforming growth factor beta binding;GO:0070062,cellular_component extracellular exosome;GO:2000515,biological_process negative regulation of CD4-positive, alpha-beta T cell activation;GO:2000562,biological_process negative regulation of CD4-positive, alpha-beta T cell proliferation	NA	twisted gastrulation BMP signaling modulator 1 [Source:HGNC Symbol%3BAcc:HGNC:12429]
ENSG00000131236	205.63	232.31	205.98	200.24	218.48	195.02	0.0803882763453946	8.22383510964654	0.263973074759844	0.648465817730841	1:40040232-40072649:+	CAP1	21;GO:0000902,biological_process cell morphogenesis;GO:0001667,biological_process ameboidal-type cell migration;GO:0003779,molecular_function actin binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007010,biological_process cytoskeleton organization;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007165,biological_process signal transduction;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0008154,biological_process actin polymerization or depolymerization;GO:0008179,molecular_function adenylate cyclase binding;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	cyclase associated actin cytoskeleton regulatory protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20040]
ENSG00000111801	18.83	17.02	17.35	16.67	17.14	16.74	0.0890698307816665	4.92966133349433	0.264296699497178	0.648976054927637	6:26440471-26453415:+	BTN3A3	6;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002456,biological_process T cell mediated immunity;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	butyrophilin subfamily 3 member A3 [Source:HGNC Symbol%3BAcc:HGNC:1140]
ENSG00000149089	67.49	74.34	67.76	68.73	65.84	65.21	0.0773614125221206	5.66699236302528	0.264297868401383	0.648976054927637	11:34853093-34916499:-	APIP	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0008270,molecular_function zinc ion binding;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009086,biological_process methionine biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0019509,biological_process L-methionine biosynthetic process from methylthioadenosine;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046570,molecular_function methylthioribulose 1-phosphate dehydratase activity;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0070269,biological_process pyroptosis;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade	mtnB; methylthioribulose-1-phosphate dehydratase [EC:4.2.1.109]; K08964	APAF1 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:17581]
ENSG00000204104	10.29	9.32	10.12	11.33	10.58	10.27	-0.0966926668826298	4.45193438330619	0.264401316784912	0.648976054927637	2:238320440-238400900:+	TRAF3IP1	31;GO:0001738,biological_process morphogenesis of a polarized epithelium;GO:0001822,biological_process kidney development;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0008017,molecular_function microtubule binding;GO:0021532,biological_process neural tube patterning;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0031076,biological_process embryonic camera-type eye development;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0035050,biological_process embryonic heart tube development;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0036342,biological_process post-anal tail morphogenesis;GO:0042073,biological_process intraciliary transport;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0050687,biological_process negative regulation of defense response to virus;GO:0060271,biological_process cilium morphogenesis;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:1901621,biological_process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	NA	TRAF3 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17861]
ENSG00000111726	56.69	50.79	49.18	50.66	48.81	50.12	0.0797089527203187	6.05894349384921	0.264422437714351	0.648976054927637	12:22046173-22065674:+	CMAS	7;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006054,biological_process N-acetylneuraminate metabolic process;GO:0008781,molecular_function N-acylneuraminate cytidylyltransferase activity;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity	neuA; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43]; K00983	cytidine monophosphate N-acetylneuraminic acid synthetase [Source:HGNC Symbol%3BAcc:HGNC:18290]
ENSG00000121297	6.89	6.11	6.37	6.03	5.72	6.45	0.104728797425322	4.38319335047373	0.26448447869536	0.648976054927637	19:31274944-31349547:-	TSHZ3	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0010468,biological_process regulation of gene expression;GO:0030426,cellular_component growth cone;GO:0042995,cellular_component cell projection;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060291,biological_process long-term synaptic potentiation	TSHZ; teashirt; K09236	teashirt zinc finger homeobox 3 [Source:HGNC Symbol%3BAcc:HGNC:30700]
ENSG00000103264	6.76	6.79	7.56	5.84	6.45	7.10	0.13357793337547	3.54403240260245	0.26454108514832	0.648976054927637	16:87326986-87392142:-	FBXO31	18;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030332,molecular_function cyclin binding;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0043025,cellular_component neuronal cell body;GO:0043687,biological_process post-translational protein modification;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:2001224,biological_process positive regulation of neuron migration	NA	F-box protein 31 [Source:HGNC Symbol%3BAcc:HGNC:16510]
ENSG00000154727	13.64	14.88	15.94	17.15	15.31	15.75	-0.106413559278661	4.40627391184453	0.264546752431632	0.648976054927637	21:25734569-25772460:+	GABPA	27;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007005,biological_process mitochondrion organization;GO:0010628,biological_process positive regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0033613,molecular_function activating transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045653,biological_process negative regulation of megakaryocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:1903351,biological_process cellular response to dopamine	NA	GA binding protein transcription factor alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:4071]
ENSG00000140382	20.79	18.42	21.38	17.16	20.29	19.28	0.112883034047374	4.36377382560819	0.264638411944754	0.649072635342865	15:77420411-77485607:+	HMG20A	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0042802,molecular_function identical protein binding;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0046982,molecular_function protein heterodimerization activity	NA	high mobility group 20A [Source:HGNC Symbol%3BAcc:HGNC:5001]
ENSG00000168288	104.73	106.18	104.45	118.81	105.11	110.95	-0.0752362518549587	6.74837437095591	0.264746135954658	0.649141570598639	2:149569633-149587816:-	MMADHC	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0009108,biological_process coenzyme biosynthetic process;GO:0009235,biological_process cobalamin metabolic process	NA	methylmalonic aciduria and homocystinuria%2C cblD type [Source:HGNC Symbol%3BAcc:HGNC:25221]
ENSG00000280789	15.48	16.18	14.97	14.54	15.92	12.09	0.143251528584628	3.51662941245473	0.264831768747978	0.649141570598639	16:29815951-29820117:+	PAGR1	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0030331,molecular_function estrogen receptor binding;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0035097,cellular_component histone methyltransferase complex;GO:0044666,cellular_component MLL3/4 complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1902808,biological_process positive regulation of cell cycle G1/S phase transition	NA	PAXIP1 associated glutamate rich protein 1 [Source:HGNC Symbol%3BAcc:HGNC:28707]
ENSG00000142347	0.90	0.74	0.65	0.64	0.54	0.73	0.273068705281978	1.33359424181282	0.264945404720594	0.649141570598639	19:8520789-8577577:-	MYO1F	8;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0008150,biological_process biological_process;GO:0016459,cellular_component myosin complex;GO:0016461,cellular_component unconventional myosin complex	MYO1; myosin I; K10356	myosin IF [Source:HGNC Symbol%3BAcc:HGNC:7600]
ENSG00000184432	95.83	114.07	89.21	88.46	103.26	89.17	0.101735472041685	8.08392192260546	0.264948212895548	0.649141570598639	3:139355599-139389732:-	COPB2	21;GO:0000139,cellular_component Golgi membrane;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:1901998,biological_process toxin transport	NA	coatomer protein complex subunit beta 2 [Source:HGNC Symbol%3BAcc:HGNC:2232]
ENSG00000135956	20.38	22.22	21.85	18.14	20.82	20.88	0.114339546795159	3.89956068503699	0.265095644840528	0.649141570598639	2:96248515-96265994:-	TMEM127	11;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0007032,biological_process endosome organization;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0032006,biological_process regulation of TOR signaling;GO:0032007,biological_process negative regulation of TOR signaling	NA	transmembrane protein 127 [Source:HGNC Symbol%3BAcc:HGNC:26038]
ENSG00000164362	0.87	0.70	0.63	1.08	0.83	0.79	-0.266675505031016	1.55465987583733	0.265095646264692	0.649141570598639	5:1253146-1295069:-	TERT	72;GO:0000049,molecular_function tRNA binding;GO:0000333,cellular_component telomerase catalytic core complex;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001172,biological_process transcription, RNA-templated;GO:0001223,molecular_function transcription coactivator binding;GO:0003677,molecular_function DNA binding;GO:0003720,molecular_function telomerase activity;GO:0003721,molecular_function telomerase RNA reverse transcriptase activity;GO:0003723,molecular_function RNA binding;GO:0003964,molecular_function RNA-directed DNA polymerase activity;GO:0003968,molecular_function RNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006278,biological_process RNA-dependent DNA biosynthetic process;GO:0007004,biological_process telomere maintenance via telomerase;GO:0007005,biological_process mitochondrion organization;GO:0008022,molecular_function protein C-terminus binding;GO:0010629,biological_process negative regulation of gene expression;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0022616,biological_process DNA strand elongation;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031379,cellular_component RNA-directed RNA polymerase complex;GO:0031647,biological_process regulation of protein stability;GO:0032092,biological_process positive regulation of protein binding;GO:0032774,biological_process RNA biosynthetic process;GO:0042162,molecular_function telomeric DNA binding;GO:0042635,biological_process positive regulation of hair cycle;GO:0042645,cellular_component mitochondrial nucleoid;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046326,biological_process positive regulation of glucose import;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051087,molecular_function chaperone binding;GO:0060253,biological_process negative regulation of glial cell proliferation;GO:0070034,molecular_function telomerase RNA binding;GO:0070200,biological_process establishment of protein localization to telomere;GO:0071456,biological_process cellular response to hypoxia;GO:0071897,biological_process DNA biosynthetic process;GO:0090399,biological_process replicative senescence;GO:0098680,molecular_function template-free RNA nucleotidyltransferase;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903620,biological_process positive regulation of transdifferentiation;GO:1903704,biological_process negative regulation of production of siRNA involved in RNA interference;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1904751,biological_process positive regulation of protein localization to nucleolus;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:1990572,cellular_component TERT-RMRP complex;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2000648,biological_process positive regulation of stem cell proliferation;GO:2000773,biological_process negative regulation of cellular senescence;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]; K11126	telomerase reverse transcriptase [Source:HGNC Symbol%3BAcc:HGNC:11730]
ENSG00000173221	51.53	64.91	71.98	58.39	55.33	59.48	0.129729773574834	4.26959416444564	0.265099705755415	0.649141570598639	5:95751318-95823005:-	GLRX	17;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0009055,molecular_function electron carrier activity;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015038,molecular_function glutathione disulfide oxidoreductase activity;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016740,molecular_function transferase activity;GO:0045454,biological_process cell redox homeostasis;GO:0045838,biological_process positive regulation of membrane potential;GO:0047485,molecular_function protein N-terminus binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0080058,biological_process protein deglutathionylation;GO:0097573,molecular_function glutathione oxidoreductase activity;GO:2000651,biological_process positive regulation of sodium ion transmembrane transporter activity	NA	glutaredoxin [Source:HGNC Symbol%3BAcc:HGNC:4330]
ENSG00000003249	2.21	2.28	2.64	2.68	2.86	2.97	-0.242267669329959	1.58542260669268	0.265109755653892	0.649141570598639	16:90004864-90020128:-	DBNDD1	3;GO:0005737,cellular_component cytoplasm;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031175,biological_process neuron projection development	NA	dysbindin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28455]
ENSG00000118898	1.01	1.36	1.19	1.11	1.40	1.56	-0.197345708063761	2.77198988119031	0.265137175778224	0.649141570598639	16:4882506-4960741:-	PPL	17;GO:0001533,cellular_component cornified envelope;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0031424,biological_process keratinization;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification	NA	periplakin [Source:HGNC Symbol%3BAcc:HGNC:9273]
ENSG00000039650	17.46	18.37	18.28	17.64	16.16	17.51	0.0860478293743378	4.93043784832039	0.265218144726069	0.649194734053938	19:49859881-49878351:-	PNKP	37;GO:0000166,molecular_function nucleotide binding;GO:0000718,biological_process nucleotide-excision repair, DNA damage removal;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0008152,biological_process metabolic process;GO:0009314,biological_process response to radiation;GO:0010836,biological_process negative regulation of protein ADP-ribosylation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0017076,molecular_function purine nucleotide binding;GO:0019201,molecular_function nucleotide kinase activity;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0046403,molecular_function polynucleotide 3'-phosphatase activity;GO:0046404,molecular_function ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0046939,biological_process nucleotide phosphorylation;GO:0051973,biological_process positive regulation of telomerase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0098504,biological_process DNA 3' dephosphorylation involved in DNA repair;GO:0098506,biological_process polynucleotide 3' dephosphorylation;GO:1904355,biological_process positive regulation of telomere capping	NA	polynucleotide kinase 3'-phosphatase [Source:HGNC Symbol%3BAcc:HGNC:9154]
ENSG00000091490	75.29	65.22	75.25	81.00	70.75	78.84	-0.0833534649990802	8.06972718890813	0.265284973768226	0.649194734053938	4:25747426-25863760:-	SEL1L3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	SEL1L family member 3 [Source:HGNC Symbol%3BAcc:HGNC:29108]
ENSG00000206535	5.30	6.67	5.78	6.53	7.68	6.50	-0.223157360907247	1.93155115255177	0.265350750928188	0.649194734053938	3:100401192-100456319:+	LNP1	NA	NA	leukemia NUP98 fusion partner 1 [Source:HGNC Symbol%3BAcc:HGNC:28014]
ENSG00000076258	2.70	3.54	2.42	3.53	3.53	2.90	-0.208044364083245	2.40996706539041	0.265397540173381	0.649194734053938	1:171314207-171342084:+	FMO4	13;GO:0004497,molecular_function monooxygenase activity;GO:0004499,molecular_function N,N-dimethylaniline monooxygenase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031090,cellular_component organelle membrane;GO:0042737,biological_process drug catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process	FMO; dimethylaniline monooxygenase (N-oxide forming) [EC:1.14.13.8]; K00485	flavin containing monooxygenase 4 [Source:HGNC Symbol%3BAcc:HGNC:3772]
ENSG00000180998	0.60	0.75	0.53	0.69	1.14	0.75	-0.459332596291737	0.252045102622171	0.265420387925863	0.649194734053938	14:52553147-52637713:+	GPR137C	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 137C [Source:HGNC Symbol%3BAcc:HGNC:25445]
ENSG00000140299	34.04	33.35	32.42	29.13	33.46	32.53	0.0810666966557306	5.60789937084619	0.265629727948458	0.649562623762368	15:59659145-59689534:-	BNIP2	23;GO:0001824,biological_process blastocyst development;GO:0005096,molecular_function GTPase activator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007098,biological_process centrosome cycle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031616,cellular_component spindle pole centrosome;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051057,biological_process positive regulation of small GTPase mediated signal transduction;GO:0051146,biological_process striated muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation	NA	BCL2 interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1083]
ENSG00000266086	239.98	208.09	282.53	283.39	244.65	268.04	-0.10784090350564	5.57376461547628	0.265675456444175	0.649562623762368	17:57989037-58005253:-	AC015813.2	NA	NA	NA
ENSG00000160404	3.50	2.71	3.52	3.85	4.10	3.49	-0.200433731724692	2.05788183121854	0.266045368658226	0.650338944693689	9:127731523-127735317:-	TOR2A	8;GO:0000166,molecular_function nucleotide binding;GO:0005179,molecular_function hormone activity;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051260,biological_process protein homooligomerization	NA	torsin family 2 member A [Source:HGNC Symbol%3BAcc:HGNC:11996]
ENSG00000144214	2.18	1.81	2.91	2.44	1.69	1.21	0.402965532200558	0.425160593235148	0.266140672646349	0.650343886463449	2:99284237-99304742:-	LYG1	7;GO:0003796,molecular_function lysozyme activity;GO:0005576,cellular_component extracellular region;GO:0008152,biological_process metabolic process;GO:0009253,biological_process peptidoglycan catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016998,biological_process cell wall macromolecule catabolic process	NA	lysozyme g1 [Source:HGNC Symbol%3BAcc:HGNC:27014]
ENSG00000204219	2.29	2.22	1.84	1.74	2.18	1.30	0.297112789471849	1.14928399067267	0.266152174593919	0.650343886463449	1:23381060-23424740:-	TCEA3	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	transcription elongation factor A3 [Source:HGNC Symbol%3BAcc:HGNC:11615]
ENSG00000105723	24.19	24.31	25.80	22.77	23.89	24.18	0.0812558773527626	5.1747619964488	0.266236601618544	0.650422148374529	19:42230185-42242625:-	GSK3A	62;GO:0000166,molecular_function nucleotide binding;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0003214,biological_process cardiac left ventricle morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006468,biological_process protein phosphorylation;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0007568,biological_process aging;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010905,biological_process negative regulation of UDP-glucose catabolic process;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0030877,cellular_component beta-catenin destruction complex;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0036016,biological_process cellular response to interleukin-3;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0044027,biological_process hypermethylation of CpG island;GO:0045719,biological_process negative regulation of glycogen biosynthetic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045823,biological_process positive regulation of heart contraction;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046325,biological_process negative regulation of glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0050321,molecular_function tau-protein kinase activity;GO:0061052,biological_process negative regulation of cell growth involved in cardiac muscle cell development;GO:0071285,biological_process cellular response to lithium ion;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071879,biological_process positive regulation of adrenergic receptor signaling pathway;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0098794,cellular_component postsynapse;GO:0099565,biological_process chemical synaptic transmission, postsynaptic;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1904227,biological_process negative regulation of glycogen synthase activity, transferring glucose-1-phosphate;GO:2000077,biological_process negative regulation of type B pancreatic cell development;GO:2000171,biological_process negative regulation of dendrite development;GO:2000466,biological_process negative regulation of glycogen (starch) synthase activity;GO:2000467,biological_process positive regulation of glycogen (starch) synthase activity	GSK3A; glycogen synthase kinase 3 alpha [EC:2.7.11.26]; K08822	glycogen synthase kinase 3 alpha [Source:HGNC Symbol%3BAcc:HGNC:4616]
ENSG00000265491	59.32	57.21	56.41	55.17	56.97	53.51	0.0750359891314312	5.69040564556973	0.266363409381877	0.650603896233222	1:145738867-145824077:-	RNF115	16;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination	NA	ring finger protein 115 [Source:HGNC Symbol%3BAcc:HGNC:18154]
ENSG00000179950	57.10	60.30	57.20	62.35	63.62	59.06	-0.0729030225984661	6.86618188049619	0.266489107380725	0.650782862466444	8:143816343-143829859:-	PUF60	17;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008380,biological_process RNA splicing;GO:0019907,cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0030054,cellular_component cell junction;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042802,molecular_function identical protein binding;GO:0045296,molecular_function cadherin binding	PUF60; poly(U)-binding-splicing factor PUF60; K12838	poly(U) binding splicing factor 60 [Source:HGNC Symbol%3BAcc:HGNC:17042]
ENSG00000107968	4.88	3.86	4.28	3.48	4.46	3.66	0.190184417541001	2.62442143986373	0.266717228728499	0.65121183324289	10:30433936-30461833:+	MAP3K8	25;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000287,molecular_function magnesium ion binding;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031295,biological_process T cell costimulation;GO:0032147,biological_process activation of protein kinase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0051403,biological_process stress-activated MAPK cascade	MAP3K8, COT; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]; K04415	mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol%3BAcc:HGNC:6860]
ENSG00000240230	29.40	28.32	33.80	38.11	30.03	33.25	-0.131600272950313	3.84899166994626	0.266886399748634	0.651257692996638	7:898777-975599:-	COX19	5;GO:0005737,cellular_component cytoplasm;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0009060,biological_process aerobic respiration;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	COX19%2C cytochrome c oxidase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:28074]
ENSG00000068323	31.20	32.46	34.94	34.29	34.38	36.16	-0.0766570340340534	5.87524724932212	0.266892879662214	0.651257692996638	X:49028725-49043486:-	TFE3	19;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006959,biological_process humoral immune response;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity	TFE3; transcription factor E3; K09105	transcription factor binding to IGHM enhancer 3 [Source:HGNC Symbol%3BAcc:HGNC:11752]
ENSG00000197766	6.97	7.11	7.64	6.82	5.83	6.76	0.173142111342363	2.45901178684304	0.26696851695737	0.651257692996638	19:859642-863630:+	CFD	17;GO:0002376,biological_process immune system process;GO:0002576,biological_process platelet degranulation;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006956,biological_process complement activation;GO:0006957,biological_process complement activation, alternative pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0031093,cellular_component platelet alpha granule lumen;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	CFD; complement factor D [EC:3.4.21.46]; K01334	complement factor D [Source:HGNC Symbol%3BAcc:HGNC:2771]
ENSG00000197375	10.03	9.87	10.29	11.06	10.30	11.31	-0.10183555851424	4.21353330647769	0.267000322257129	0.651257692996638	5:132369751-132395614:+	SLC22A5	33;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006855,biological_process drug transmembrane transport;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0009437,biological_process carnitine metabolic process;GO:0015226,molecular_function carnitine transmembrane transporter activity;GO:0015238,molecular_function drug transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015491,molecular_function cation:cation antiporter activity;GO:0015651,molecular_function quaternary ammonium group transmembrane transporter activity;GO:0015697,biological_process quaternary ammonium group transport;GO:0015711,biological_process organic anion transport;GO:0015879,biological_process carnitine transport;GO:0015893,biological_process drug transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0030165,molecular_function PDZ domain binding;GO:0031526,cellular_component brush border membrane;GO:0052106,biological_process quorum sensing involved in interaction with host;GO:0055085,biological_process transmembrane transport;GO:0060731,biological_process positive regulation of intestinal epithelial structure maintenance;GO:0070062,cellular_component extracellular exosome;GO:0070715,biological_process sodium-dependent organic cation transport;GO:1902603,biological_process carnitine transmembrane transport	SLC22A4_5, OCTN; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5; K08202	solute carrier family 22 member 5 [Source:HGNC Symbol%3BAcc:HGNC:10969]
ENSG00000126005	76.93	109.92	93.64	83.66	87.95	85.17	0.129175841845224	4.25707949913756	0.267004003954363	0.651257692996638	20:35201744-35278131:-	MMP24-AS1	NA	NA	MMP24 antisense RNA 1 [Source:HGNC Symbol%3BAcc:HGNC:44421]
ENSG00000143226	1.13	1.62	1.53	1.48	1.86	1.99	-0.32352259510371	0.887133779187546	0.267050806199379	0.651257692996638	1:161505429-161524013:+	FCGR2A	10;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019864,molecular_function IgG binding;GO:0030667,cellular_component secretory granule membrane;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a; K06472	Fc fragment of IgG receptor IIa [Source:HGNC Symbol%3BAcc:HGNC:3616]
ENSG00000134684	212.95	183.83	208.35	229.11	199.80	217.08	-0.0819536422221818	8.36957862582629	0.267153339151165	0.651262829544116	1:32775236-32818153:-	YARS	21;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004831,molecular_function tyrosine-tRNA ligase activity;GO:0004871,molecular_function signal transducer activity;GO:0005153,molecular_function interleukin-8 receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006437,biological_process tyrosyl-tRNA aminoacylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0016604,cellular_component nuclear body;GO:0016874,molecular_function ligase activity;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0017102,cellular_component methionyl glutamyl tRNA synthetase complex	YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]; K01866	tyrosyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:12840]
ENSG00000115310	158.98	154.11	155.37	160.02	162.81	170.98	-0.064127942732682	9.21175031144867	0.267226756994574	0.651262829544116	2:54972186-55112621:-	RTN4	37;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007399,biological_process nervous system development;GO:0007413,biological_process axonal fasciculation;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021801,biological_process cerebral cortex radial glia guided migration;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0030517,biological_process negative regulation of axon extension;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0045296,molecular_function cadherin binding;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050821,biological_process protein stabilization;GO:0051292,biological_process nuclear pore complex assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051960,biological_process regulation of nervous system development;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0070062,cellular_component extracellular exosome;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0071786,biological_process endoplasmic reticulum tubular network organization;GO:0071787,biological_process endoplasmic reticulum tubular network assembly;GO:1905552,biological_process positive regulation of protein localization to endoplasmic reticulum;GO:1905580,biological_process positive regulation of ERBB3 signaling pathway;GO:2000172,biological_process regulation of branching morphogenesis of a nerve	NA	reticulon 4 [Source:HGNC Symbol%3BAcc:HGNC:14085]
ENSG00000015568	0.76	0.51	0.74	0.54	0.65	0.55	0.246932707090318	1.82543800754746	0.267256515760796	0.651262829544116	2:109792757-109857695:+	RGPD5	4;GO:0000042,biological_process protein targeting to Golgi;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0046907,biological_process intracellular transport	NA	RANBP2-like and GRIP domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:32418]
ENSG00000132326	1.89	1.50	2.05	1.99	1.91	2.30	-0.162857509898843	2.91091053725009	0.267274369272262	0.651262829544116	2:238244037-238290102:-	PER2	33;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0002931,biological_process response to ischemia;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005978,biological_process glycogen biosynthetic process;GO:0006094,biological_process gluconeogenesis;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006631,biological_process fatty acid metabolic process;GO:0007623,biological_process circadian rhythm;GO:0019229,biological_process regulation of vasoconstriction;GO:0019249,biological_process lactate biosynthetic process;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032922,biological_process circadian regulation of gene expression;GO:0042752,biological_process regulation of circadian rhythm;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048511,biological_process rhythmic process;GO:0050767,biological_process regulation of neurogenesis;GO:0050796,biological_process regulation of insulin secretion;GO:0050872,biological_process white fat cell differentiation;GO:0051726,biological_process regulation of cell cycle;GO:0051946,biological_process regulation of glutamate uptake involved in transmission of nerve impulse;GO:0070345,biological_process negative regulation of fat cell proliferation;GO:0070932,biological_process histone H3 deacetylation;GO:0097167,biological_process circadian regulation of translation;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding	PER2; period circadian protein 2; K02633	period circadian clock 2 [Source:HGNC Symbol%3BAcc:HGNC:8846]
ENSG00000244693	1.24	1.11	0.92	1.38	1.24	1.30	-0.248841287468911	1.56096976394589	0.267315243416359	0.651262829544116	7:144266700-144269288:-	CTAGE8	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CTAGE family member 8 [Source:HGNC Symbol%3BAcc:HGNC:37294]
ENSG00000214193	2.40	1.85	2.63	1.95	1.84	2.26	0.210545857021757	2.34308611544789	0.267382981073942	0.651300028271359	1:36306386-36324886:+	SH3D21	4;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0070062,cellular_component extracellular exosome	NA	SH3 domain containing 21 [Source:HGNC Symbol%3BAcc:HGNC:26236]
ENSG00000130560	31.21	28.94	32.17	27.92	29.59	30.44	0.0852668109510272	5.19811127175709	0.267474783665288	0.651395819038104	9:135932968-135961380:-	UBAC1	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016567,biological_process protein ubiquitination;GO:0070062,cellular_component extracellular exosome	NA	UBA domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30221]
ENSG00000080298	1.98	1.92	2.15	2.05	2.10	2.83	-0.192437844268655	2.56274301580671	0.26769866016786	0.651570660868648	9:3218296-3526004:-	RFX3	27;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003309,biological_process type B pancreatic cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0030154,biological_process cell differentiation;GO:0031018,biological_process endocrine pancreas development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048469,biological_process cell maturation;GO:0050796,biological_process regulation of insulin secretion;GO:0060271,biological_process cilium morphogenesis;GO:0060285,biological_process cilium-dependent cell motility;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry;GO:0072560,biological_process type B pancreatic cell maturation;GO:2000078,biological_process positive regulation of type B pancreatic cell development	NA	regulatory factor X3 [Source:HGNC Symbol%3BAcc:HGNC:9984]
ENSG00000186350	26.04	31.10	27.61	24.53	29.66	25.27	0.10083611199279	5.24802879990522	0.267711645904565	0.651570660868648	9:134317097-134440585:+	RXRA	63;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0001890,biological_process placenta development;GO:0001893,biological_process maternal placenta development;GO:0001972,molecular_function retinoic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003708,molecular_function retinoic acid receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004886,molecular_function 9-cis retinoic acid receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006766,biological_process vitamin metabolic process;GO:0007507,biological_process heart development;GO:0007566,biological_process embryo implantation;GO:0008134,molecular_function transcription factor binding;GO:0008203,biological_process cholesterol metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015721,biological_process bile acid and bile salt transport;GO:0016032,biological_process viral process;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019048,biological_process modulation by virus of host morphology or physiology;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0031490,molecular_function chromatin DNA binding;GO:0032526,biological_process response to retinoic acid;GO:0035357,biological_process peroxisome proliferator activated receptor signaling pathway;GO:0042277,molecular_function peptide binding;GO:0042809,molecular_function vitamin D receptor binding;GO:0043010,biological_process camera-type eye development;GO:0043234,cellular_component protein complex;GO:0043235,cellular_component receptor complex;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044323,molecular_function retinoic acid-responsive element binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045994,biological_process positive regulation of translational initiation by iron;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0050692,molecular_function DBD domain binding;GO:0050693,molecular_function LBD domain binding;GO:0051289,biological_process protein homotetramerization;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0055012,biological_process ventricular cardiac muscle cell differentiation;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060528,biological_process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060687,biological_process regulation of branching involved in prostate gland morphogenesis;GO:0070644,molecular_function vitamin D response element binding;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1901522,biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	RXRA, NR2B1; retinoid X receptor alpha; K08524	retinoid X receptor alpha [Source:HGNC Symbol%3BAcc:HGNC:10477]
ENSG00000232112	622.02	613.71	526.32	657.08	599.63	625.54	-0.0843583214491963	6.86819770873194	0.267754606067051	0.651570660868648	3:48440256-48444208:+	TMA7	NA	NA	translation machinery associated 7 homolog [Source:HGNC Symbol%3BAcc:HGNC:26932]
ENSG00000117298	67.79	65.65	70.59	78.03	62.96	78.10	-0.0906969444966114	7.44473348061664	0.267776930520171	0.651570660868648	1:21217246-21345504:-	ECE1	36;GO:0001921,biological_process positive regulation of receptor recycling;GO:0003100,biological_process regulation of systemic arterial blood pressure by endothelin;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007507,biological_process heart development;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009897,cellular_component external side of plasma membrane;GO:0010814,biological_process substance P catabolic process;GO:0010815,biological_process bradykinin catabolic process;GO:0010816,biological_process calcitonin catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016486,biological_process peptide hormone processing;GO:0016787,molecular_function hydrolase activity;GO:0017046,molecular_function peptide hormone binding;GO:0019229,biological_process regulation of vasoconstriction;GO:0031302,cellular_component intrinsic component of endosome membrane;GO:0031982,cellular_component vesicle;GO:0033093,cellular_component Weibel-Palade body;GO:0034959,biological_process endothelin maturation;GO:0042447,biological_process hormone catabolic process;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0043583,biological_process ear development;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060037,biological_process pharyngeal system development;GO:0070062,cellular_component extracellular exosome	NA	endothelin converting enzyme 1 [Source:HGNC Symbol%3BAcc:HGNC:3146]
ENSG00000065989	0.57	0.74	0.75	0.40	0.61	0.65	0.302729739467584	1.14911412104787	0.267809833975832	0.651570660868648	19:10416772-10469631:+	PDE4A	21;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006198,biological_process cAMP catabolic process;GO:0007165,biological_process signal transduction;GO:0007608,biological_process sensory perception of smell;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030552,molecular_function cAMP binding;GO:0032587,cellular_component ruffle membrane;GO:0035690,biological_process cellular response to drug;GO:0042995,cellular_component cell projection;GO:0043949,biological_process regulation of cAMP-mediated signaling;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	cpdP; 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]; K01120	phosphodiesterase 4A [Source:HGNC Symbol%3BAcc:HGNC:8780]
ENSG00000115241	61.53	70.89	61.29	70.12	70.33	66.03	-0.0827312258525114	6.77332473808135	0.267861522791647	0.651570660868648	2:27381193-27409687:-	PPM1G	14;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0007050,biological_process cell cycle arrest;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1G [Source:HGNC Symbol%3BAcc:HGNC:9278]
ENSG00000145907	64.33	65.04	65.89	68.69	70.07	67.80	-0.0693469868456475	6.68869375386699	0.26796499901075	0.651694657664662	5:151771044-151812785:+	G3BP1	27;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0007265,biological_process Ras protein signal transduction;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032508,biological_process DNA duplex unwinding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	G3BP stress granule assembly factor 1 [Source:HGNC Symbol%3BAcc:HGNC:30292]
ENSG00000084764	17.84	15.64	18.16	15.63	16.73	15.77	0.122109677250731	3.82809326337347	0.268192753754229	0.652120793800439	2:26970611-27027196:+	MAPRE3	14;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030496,cellular_component midbody;GO:0035371,cellular_component microtubule plus-end;GO:0042802,molecular_function identical protein binding;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051301,biological_process cell division;GO:1903033,biological_process positive regulation of microtubule plus-end binding	DPYSL5, CRAM; dihydropyrimidinase-like 5; K07529	microtubule associated protein RP/EB family member 3 [Source:HGNC Symbol%3BAcc:HGNC:6892]
ENSG00000038382	45.91	43.61	45.38	44.47	41.94	43.59	0.0652941418055421	8.72525607140351	0.268896971365401	0.653584004130184	5:14143701-14532128:+	TRIO	19;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007185,biological_process transmembrane receptor protein tyrosine phosphatase signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	trio Rho guanine nucleotide exchange factor [Source:HGNC Symbol%3BAcc:HGNC:12303]
ENSG00000168255	2.80	4.17	3.15	3.02	3.06	2.56	0.218092821263788	1.99002764705822	0.268899823498981	0.653584004130184	7:102537917-102572656:-	POLR2J3	8;GO:0001055,molecular_function RNA polymerase II activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity	RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11; K03008	RNA polymerase II subunit J3 [Source:HGNC Symbol%3BAcc:HGNC:33853]
ENSG00000110906	12.58	13.22	12.53	11.28	12.77	11.53	0.116146734464939	3.81010065591112	0.269018263272327	0.653630372052723	12:109448655-109477544:-	KCTD10	11;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005112,molecular_function Notch binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:23236]
ENSG00000075856	17.98	16.70	17.06	17.73	18.16	19.07	-0.0734846244071673	5.75691197589605	0.269099692174491	0.653630372052723	12:108522579-108561400:-	SART3	27;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000902,biological_process cell morphogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005691,cellular_component U6atac snRNP;GO:0005737,cellular_component cytoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010468,biological_process regulation of gene expression;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0017070,molecular_function U6 snRNA binding;GO:0030621,molecular_function U4 snRNA binding;GO:0030624,molecular_function U6atac snRNA binding;GO:0042393,molecular_function histone binding;GO:0048872,biological_process homeostasis of number of cells;GO:0071001,cellular_component U4/U6 snRNP;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:1903586,biological_process positive regulation of histone deubiquitination;GO:1990381,molecular_function ubiquitin-specific protease binding	NA	squamous cell carcinoma antigen recognized by T-cells 3 [Source:HGNC Symbol%3BAcc:HGNC:16860]
ENSG00000137731	65.09	70.46	52.91	55.55	62.56	53.79	0.137953989591655	3.71464368945787	0.269107803825475	0.653630372052723	11:117800843-117828698:-	FXYD2	25;GO:0001558,biological_process regulation of cell growth;GO:0005215,molecular_function transporter activity;GO:0005216,molecular_function ion channel activity;GO:0005391,molecular_function sodium:potassium-exchanging ATPase activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005890,cellular_component sodium:potassium-exchanging ATPase complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0017080,molecular_function sodium channel regulator activity;GO:0034220,biological_process ion transmembrane transport;GO:0036376,biological_process sodium ion export from cell;GO:0042127,biological_process regulation of cell proliferation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome;GO:0090662,biological_process ATP hydrolysis coupled transmembrane transport;GO:1903779,biological_process regulation of cardiac conduction;GO:1990573,biological_process potassium ion import across plasma membrane;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2); K01538	FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:4026]
ENSG00000105372	1081.45	969.50	945.51	1076.43	994.42	1117.73	-0.0777468669551187	9.20745123492584	0.269129528040076	0.653630372052723	19:41859917-41872926:+	RPS19	41;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002548,biological_process monocyte chemotaxis;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007000,biological_process nucleolus organization;GO:0007219,biological_process Notch signaling pathway;GO:0009991,biological_process response to extracellular stimulus;GO:0016020,cellular_component membrane;GO:0017134,molecular_function fibroblast growth factor binding;GO:0019083,biological_process viral transcription;GO:0019901,molecular_function protein kinase binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030218,biological_process erythrocyte differentiation;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0031640,biological_process killing of cells of other organism;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0051262,biological_process protein tetramerization;GO:0051272,biological_process positive regulation of cellular component movement;GO:0060265,biological_process positive regulation of respiratory burst involved in inflammatory response;GO:0060266,biological_process negative regulation of respiratory burst involved in inflammatory response;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein S19 [Source:HGNC Symbol%3BAcc:HGNC:10402]
ENSG00000136143	18.25	18.62	15.85	15.93	17.60	16.00	0.0987785852379657	4.73894810179795	0.269284975909444	0.653879969867748	13:47936490-48001354:-	SUCLA2	17;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004775,molecular_function succinate-CoA ligase (ADP-forming) activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006104,biological_process succinyl-CoA metabolic process;GO:0006105,biological_process succinate metabolic process;GO:0006781,biological_process succinyl-CoA pathway;GO:0008152,biological_process metabolic process;GO:0016874,molecular_function ligase activity;GO:0043209,cellular_component myelin sheath;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	LSC2; succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]; K01900	succinate-CoA ligase ADP-forming beta subunit [Source:HGNC Symbol%3BAcc:HGNC:11448]
ENSG00000082146	63.89	65.06	64.71	60.42	63.82	61.83	0.0691088253777482	6.36556095407068	0.269353451644974	0.653918324910828	2:201387857-201480846:+	STRADB	21;GO:0000166,molecular_function nucleotide binding;GO:0000902,biological_process cell morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006611,biological_process protein export from nucleus;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007254,biological_process JNK cascade;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016235,cellular_component aggresome;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0042981,biological_process regulation of apoptotic process;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	STE20-related kinase adaptor beta [Source:HGNC Symbol%3BAcc:HGNC:13205]
ENSG00000099204	15.95	15.95	14.79	15.85	17.70	16.30	-0.0833912201465147	5.35214013799776	0.269463700069487	0.654042401327602	10:114431112-114685003:-	ABLIM1	13;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0007601,biological_process visual perception;GO:0009887,biological_process organ morphogenesis;GO:0015629,cellular_component actin cytoskeleton;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis	ABLIM; actin-binding LIM protein; K07520	actin binding LIM protein 1 [Source:HGNC Symbol%3BAcc:HGNC:78]
ENSG00000110328	4.89	3.52	4.93	4.44	3.58	3.94	0.183468812529825	2.9781123655962	0.269509939804292	0.654042401327602	11:11270875-11622005:-	GALNT18	10;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 18 [Source:HGNC Symbol%3BAcc:HGNC:30488]
ENSG00000010072	5.67	6.40	6.78	6.80	6.99	7.09	-0.139289808869847	3.34282463600455	0.269742624117792	0.654407518322669	1:231337103-231355023:+	SPRTN	15;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0016607,cellular_component nuclear speck;GO:0019985,biological_process translesion synthesis;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0043130,molecular_function ubiquitin binding;GO:0046872,molecular_function metal ion binding;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0070987,biological_process error-free translesion synthesis	NA	SprT-like N-terminal domain [Source:HGNC Symbol%3BAcc:HGNC:25356]
ENSG00000198420	11.93	13.86	11.40	12.19	13.01	8.80	0.139139481365152	5.03722809266963	0.269765831890526	0.654407518322669	7:143851374-143902198:-	TCAF1	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0030336,biological_process negative regulation of cell migration;GO:0044325,molecular_function ion channel binding;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1901529,biological_process positive regulation of anion channel activity	NA	TRPM8 channel associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:22201]
ENSG00000160888	76.64	66.85	69.97	72.07	56.34	71.89	0.105022336176174	5.53498706681743	0.269937359130881	0.65465390103077	19:13150414-13154908:+	IER2	11;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030182,biological_process neuron differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048870,biological_process cell motility;GO:0071774,biological_process response to fibroblast growth factor	NA	immediate early response 2 [Source:HGNC Symbol%3BAcc:HGNC:28871]
ENSG00000091073	10.30	9.14	9.68	8.98	9.54	8.84	0.108069047536712	4.1693896383478	0.270015184750659	0.65465390103077	7:76461675-76505995:+	DTX2	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007219,biological_process Notch signaling pathway;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031965,cellular_component nuclear membrane;GO:0046872,molecular_function metal ion binding	DTX; deltex [EC:2.3.2.27]; K06058	deltex E3 ubiquitin ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:15973]
ENSG00000115211	20.76	21.75	22.26	22.82	23.54	22.59	-0.0790360336923667	5.30188482756456	0.270025616150612	0.65465390103077	2:27364351-27370486:-	EIF2B4	20;GO:0001541,biological_process ovarian follicle development;GO:0003743,molecular_function translation initiation factor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005851,cellular_component eukaryotic translation initiation factor 2B complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0009408,biological_process response to heat;GO:0009749,biological_process response to glucose;GO:0014003,biological_process oligodendrocyte development;GO:0031369,molecular_function translation initiation factor binding;GO:0032057,biological_process negative regulation of translational initiation in response to stress;GO:0042552,biological_process myelination;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044237,biological_process cellular metabolic process;GO:0051716,biological_process cellular response to stimulus	EIF2B4; translation initiation factor eIF-2B subunit delta; K03680	eukaryotic translation initiation factor 2B subunit delta [Source:HGNC Symbol%3BAcc:HGNC:3260]
ENSG00000189227	4.03	4.18	6.16	5.27	5.62	6.55	-0.261000089012601	1.56654541031388	0.270154797826556	0.654764962336154	15:67521067-67530143:+	C15orf61	1;GO:0005576,cellular_component extracellular region	NA	chromosome 15 open reading frame 61 [Source:HGNC Symbol%3BAcc:HGNC:34453]
ENSG00000274897	2.19	2.22	3.77	2.21	2.00	2.40	0.32969300076296	0.8055123856434	0.270176922346393	0.654764962336154	11:797510-799190:+	PANO1	6;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006915,biological_process apoptotic process;GO:0031647,biological_process regulation of protein stability;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process	NA	proapoptotic nucleolar protein 1 [Source:HGNC Symbol%3BAcc:HGNC:51237]
ENSG00000188295	2.84	3.71	3.60	3.12	4.09	4.55	-0.212411732578611	2.38724910842822	0.270259554451617	0.654837370565669	1:247099961-247104372:-	ZNF669	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 669 [Source:HGNC Symbol%3BAcc:HGNC:25736]
ENSG00000171388	3.97	9.10	6.69	5.19	3.94	5.78	0.370901830540285	0.544214885602286	0.270413449849956	0.655073705020195	X:129645258-129654937:-	APLN	26;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0002026,biological_process regulation of the force of heart contraction;GO:0005102,molecular_function receptor binding;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007595,biological_process lactation;GO:0007631,biological_process feeding behavior;GO:0008284,biological_process positive regulation of cell proliferation;GO:0023052,biological_process signaling;GO:0031652,biological_process positive regulation of heat generation;GO:0031704,molecular_function apelin receptor binding;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042756,biological_process drinking behavior;GO:0043576,biological_process regulation of respiratory gaseous exchange;GO:0045776,biological_process negative regulation of blood pressure;GO:0045906,biological_process negative regulation of vasoconstriction;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050878,biological_process regulation of body fluid levels;GO:0051461,biological_process positive regulation of corticotropin secretion;GO:0051466,biological_process positive regulation of corticotropin-releasing hormone secretion;GO:0060183,biological_process apelin receptor signaling pathway;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1904022,biological_process positive regulation of G-protein coupled receptor internalization	APLN; apelin; K05225	apelin [Source:HGNC Symbol%3BAcc:HGNC:16665]
ENSG00000239857	25.81	23.70	25.61	22.34	25.00	24.11	0.0877361198358526	5.07401041096439	0.2704626390259	0.655073705020195	7:876551-896436:+	GET4	11;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0051087,molecular_function chaperone binding;GO:0051220,biological_process cytoplasmic sequestering of protein;GO:0071816,biological_process tail-anchored membrane protein insertion into ER membrane;GO:0071818,cellular_component BAT3 complex;GO:1904378,biological_process maintenance of unfolded protein involved in ERAD pathway	NA	golgi to ER traffic protein 4 [Source:HGNC Symbol%3BAcc:HGNC:21690]
ENSG00000099804	49.48	50.62	52.08	55.31	50.24	57.01	-0.0845308827712667	5.22243651017621	0.270556243534386	0.6551725811534	19:531711-542092:+	CDC34	27;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006270,biological_process DNA replication initiation;GO:0006464,biological_process cellular protein modification process;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035458,biological_process cellular response to interferon-beta;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043951,biological_process negative regulation of cAMP-mediated signaling;GO:0051301,biological_process cell division;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070848,biological_process response to growth factor;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0090261,biological_process positive regulation of inclusion body assembly	UBE2R, UBC3, CDC34; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]; K02207	cell division cycle 34 [Source:HGNC Symbol%3BAcc:HGNC:1734]
ENSG00000178952	130.33	136.59	122.78	140.80	137.91	133.99	-0.0718876730691264	7.51392450190387	0.270821848179497	0.65557374516608	16:28842410-28846408:-	TUFM	16;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0016020,cellular_component membrane;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043209,cellular_component myelin sheath;GO:0045471,biological_process response to ethanol;GO:0070062,cellular_component extracellular exosome	NA	Tu translation elongation factor%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:12420]
ENSG00000087245	500.65	406.68	506.42	470.18	388.50	469.12	0.102369961034142	9.82567951927699	0.270827532845538	0.65557374516608	16:55389699-55506691:+	MMP2	35;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0001955,biological_process blood vessel maturation;GO:0001957,biological_process intramembranous ossification;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007566,biological_process embryo implantation;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030017,cellular_component sarcomere;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035987,biological_process endodermal cell differentiation;GO:0044267,biological_process cellular protein metabolic process;GO:0045089,biological_process positive regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048705,biological_process skeletal system morphogenesis;GO:0060325,biological_process face morphogenesis;GO:0060346,biological_process bone trabecula formation;GO:0071230,biological_process cellular response to amino acid stimulus;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation	MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]; K01398	matrix metallopeptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:7166]
ENSG00000164172	27.44	27.12	24.50	29.79	29.17	26.67	-0.103959819015502	4.38239155477533	0.270920927188651	0.655600787354826	5:53095678-53110063:-	MOCS2	11;GO:0000166,molecular_function nucleotide binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006777,biological_process Mo-molybdopterin cofactor biosynthetic process;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019008,cellular_component molybdopterin synthase complex;GO:0030366,molecular_function molybdopterin synthase activity;GO:0032324,biological_process molybdopterin cofactor biosynthetic process;GO:0070062,cellular_component extracellular exosome	MOCS2B, moaE; molybdopterin synthase catalytic subunit [EC:2.8.1.12]; K03635	molybdenum cofactor synthesis 2 [Source:HGNC Symbol%3BAcc:HGNC:7193]
ENSG00000179152	19.30	20.23	17.80	16.66	20.14	16.96	0.102032273851197	4.85671784933477	0.270949426830576	0.655600787354826	3:44338118-44409451:+	TCAIM	1;GO:0005739,cellular_component mitochondrion	NA	T-cell activation inhibitor%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:25241]
ENSG00000118058	10.97	11.19	10.98	11.36	11.93	11.72	-0.067493400261982	7.1022505693429	0.270997151366923	0.655600787354826	11:118436489-118526832:+	KMT2A	63;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003680,molecular_function AT DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006306,biological_process DNA methylation;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006915,biological_process apoptotic process;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008542,biological_process visual learning;GO:0009416,biological_process response to light stimulus;GO:0009791,biological_process post-embryonic development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010468,biological_process regulation of gene expression;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0032259,biological_process methylation;GO:0032411,biological_process positive regulation of transporter activity;GO:0032922,biological_process circadian regulation of gene expression;GO:0035097,cellular_component histone methyltransferase complex;GO:0035162,biological_process embryonic hemopoiesis;GO:0035640,biological_process exploration behavior;GO:0035864,biological_process response to potassium ion;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043984,biological_process histone H4-K16 acetylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044648,biological_process histone H3-K4 dimethylation;GO:0045322,molecular_function unmethylated CpG binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:0048511,biological_process rhythmic process;GO:0048536,biological_process spleen development;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050890,biological_process cognition;GO:0051568,biological_process histone H3-K4 methylation;GO:0051569,biological_process regulation of histone H3-K4 methylation;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0051899,biological_process membrane depolarization;GO:0060216,biological_process definitive hemopoiesis;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0071339,cellular_component MLL1 complex;GO:0071440,biological_process regulation of histone H3-K14 acetylation;GO:0080182,biological_process histone H3-K4 trimethylation;GO:1901674,biological_process regulation of histone H3-K27 acetylation;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:2000615,biological_process regulation of histone H3-K9 acetylation;GO:2001040,biological_process positive regulation of cellular response to drug	MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]; K09186	lysine methyltransferase 2A [Source:HGNC Symbol%3BAcc:HGNC:7132]
ENSG00000183474	4.67	4.98	4.38	5.14	4.89	5.87	-0.177739991420107	2.63056443743482	0.271125169577243	0.655782683157116	5:69560207-69594723:+	GTF2H2C	14;GO:0000439,cellular_component core TFIIH complex;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005675,cellular_component holo TFIIH complex;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008270,molecular_function zinc ion binding;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding	TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2; K03142	GTF2H2 family member C [Source:HGNC Symbol%3BAcc:HGNC:31394]
ENSG00000163947	5.95	5.07	5.29	6.18	5.48	6.29	-0.121032667404123	3.76076425094072	0.271321870971134	0.656130602837461	3:56727417-57079329:-	ARHGEF3	12;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007266,biological_process Rho protein signal transduction;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho guanine nucleotide exchange factor 3 [Source:HGNC Symbol%3BAcc:HGNC:683]
ENSG00000163389	8.19	9.18	6.82	7.69	7.28	7.03	0.139228692828287	3.55073024193568	0.27143107886258	0.656142485638365	3:119468937-119494708:+	POGLUT1	23;GO:0001756,biological_process somitogenesis;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0006664,biological_process glycolipid metabolic process;GO:0007275,biological_process multicellular organism development;GO:0007369,biological_process gastrulation;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0010470,biological_process regulation of gastrulation;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018242,biological_process protein O-linked glycosylation via serine;GO:0030158,molecular_function protein xylosyltransferase activity;GO:0035251,molecular_function UDP-glucosyltransferase activity;GO:0035252,molecular_function UDP-xylosyltransferase activity;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0046527,molecular_function glucosyltransferase activity;GO:0048318,biological_process axial mesoderm development;GO:0048339,biological_process paraxial mesoderm development;GO:0060537,biological_process muscle tissue development;GO:0070062,cellular_component extracellular exosome;GO:0072358,biological_process cardiovascular system development	RUMI, KTELC1; protein glucosyltransferase [EC:2.4.1.-]; K13667	protein O-glucosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:22954]
ENSG00000175600	2.60	1.76	1.90	2.16	3.35	2.11	-0.256285137060636	1.98146245193534	0.271432503323371	0.656142485638365	7:40134976-40860763:+	SUGCT	4;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0016740,molecular_function transferase activity;GO:0047369,molecular_function succinate-hydroxymethylglutarate CoA-transferase activity	NA	succinyl-CoA:glutarate-CoA transferase [Source:HGNC Symbol%3BAcc:HGNC:16001]
ENSG00000137872	4.98	5.36	4.78	4.98	5.81	5.65	-0.114200784596268	4.11351858197556	0.271549039147275	0.65622579203703	15:47184100-47774223:+	SEMA6D	13;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021591,biological_process ventricular system development;GO:0030154,biological_process cell differentiation;GO:0030215,molecular_function semaphorin receptor binding	SEMA6; semaphorin 6; K06842	semaphorin 6D [Source:HGNC Symbol%3BAcc:HGNC:16770]
ENSG00000126903	17.48	17.54	18.54	16.33	17.44	17.09	0.0873405628985281	4.80428095592223	0.271617033080462	0.65622579203703	X:154487305-154490690:-	SLC10A3	9;GO:0006810,biological_process transport;GO:0008508,molecular_function bile acid:sodium symporter activity;GO:0010033,biological_process response to organic substance;GO:0015293,molecular_function symporter activity;GO:0015721,biological_process bile acid and bile salt transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032526,biological_process response to retinoic acid;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 10 member 3 [Source:HGNC Symbol%3BAcc:HGNC:22979]
ENSG00000158483	3.52	2.68	5.62	6.30	3.90	4.71	-0.301812639057701	1.6084047709674	0.271625563480727	0.65622579203703	11:71787509-71801236:+	FAM86C1	5;GO:0005515,molecular_function protein binding;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex	NA	family with sequence similarity 86 member C1 [Source:HGNC Symbol%3BAcc:HGNC:25561]
ENSG00000185627	66.75	73.12	61.92	74.01	69.08	71.87	-0.0823169998508004	6.40985562546517	0.271717792241352	0.656320870809866	11:236545-252984:+	PSMD13	41;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0007127,biological_process meiosis I;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043248,biological_process proteasome assembly;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD13, RPN9; 26S proteasome regulatory subunit N9; K03039	proteasome 26S subunit%2C non-ATPase 13 [Source:HGNC Symbol%3BAcc:HGNC:9558]
ENSG00000141429	59.36	67.21	51.76	53.10	60.24	54.48	0.097226667714361	6.61014976813548	0.271946002887963	0.656744306196165	18:35581116-35711834:+	GALNT1	19;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005576,cellular_component extracellular region;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018242,biological_process protein O-linked glycosylation via serine;GO:0018243,biological_process protein O-linked glycosylation via threonine;GO:0030145,molecular_function manganese ion binding;GO:0030246,molecular_function carbohydrate binding;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:4123]
ENSG00000115750	11.46	12.71	12.57	13.31	12.71	13.47	-0.0965028732998961	4.58714523784087	0.272070097159728	0.656891468081222	2:9843353-9934416:+	TAF1B	22;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0001187,molecular_function transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting;GO:0001188,biological_process RNA polymerase I transcriptional preinitiation complex assembly;GO:0001189,biological_process RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005668,cellular_component RNA polymerase transcription factor SL1 complex;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006360,biological_process transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0017025,molecular_function TBP-class protein binding;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070860,cellular_component RNA polymerase I core factor complex	NA	TATA-box binding protein associated factor%2C RNA polymerase I subunit B [Source:HGNC Symbol%3BAcc:HGNC:11533]
ENSG00000167216	4.78	4.33	4.10	5.14	4.34	5.27	-0.147698170002681	3.19159856528349	0.272161805840465	0.656891468081222	18:46917491-47102243:+	KATNAL2	10;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008568,molecular_function microtubule-severing ATPase activity;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity	NA	katanin catalytic subunit A1 like 2 [Source:HGNC Symbol%3BAcc:HGNC:25387]
ENSG00000151882	66.73	64.71	69.93	73.69	69.47	72.90	-0.0874958744282226	4.73924707731521	0.272227895712625	0.656891468081222	5:43376644-43412391:-	CCL28	14;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0006935,biological_process chemotaxis;GO:0006955,biological_process immune response;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007584,biological_process response to nutrient;GO:0008009,molecular_function chemokine activity;GO:0060326,biological_process cell chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:1903237,biological_process negative regulation of leukocyte tethering or rolling	CCL28; C-C motif chemokine 28; K05513	C-C motif chemokine ligand 28 [Source:HGNC Symbol%3BAcc:HGNC:17700]
ENSG00000100632	399.39	404.86	390.81	425.31	430.58	407.53	-0.0688484868963838	7.005354231643	0.272276062093681	0.656891468081222	14:69380122-69398627:-	ERH	10;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006213,biological_process pyrimidine nucleoside metabolic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0007049,biological_process cell cycle;GO:0008327,molecular_function methyl-CpG binding;GO:0030496,cellular_component midbody;GO:0034709,cellular_component methylosome;GO:0045747,biological_process positive regulation of Notch signaling pathway	NA	ERH%2C mRNA splicing and mitosis factor [Source:HGNC Symbol%3BAcc:HGNC:3447]
ENSG00000066933	7.99	7.37	8.10	7.32	7.71	7.48	0.0743976013662161	5.94087896209487	0.27228994416207	0.656891468081222	15:71822288-72118577:-	MYO9A	18;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007601,biological_process visual perception;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016459,cellular_component myosin complex;GO:0016461,cellular_component unconventional myosin complex;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	myosin IXA [Source:HGNC Symbol%3BAcc:HGNC:7608]
ENSG00000170035	84.73	89.70	93.97	84.65	89.51	82.53	0.0761100852470039	6.07045408717162	0.272324457806007	0.656891468081222	2:180967247-181076585:+	UBE2E3	15;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0040008,biological_process regulation of growth;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination	UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]; K06689	ubiquitin conjugating enzyme E2 E3 [Source:HGNC Symbol%3BAcc:HGNC:12479]
ENSG00000013375	31.20	33.41	28.75	27.78	32.65	27.90	0.0894918240174306	5.88712840730286	0.272484605877026	0.657049170529318	6:83161149-83193936:-	PGM3	17;GO:0000287,molecular_function magnesium ion binding;GO:0004610,molecular_function phosphoacetylglucosamine mutase activity;GO:0004614,molecular_function phosphoglucomutase activity;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006041,biological_process glucosamine metabolic process;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0006487,biological_process protein N-linked glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0007283,biological_process spermatogenesis;GO:0016853,molecular_function isomerase activity;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0019255,biological_process glucose 1-phosphate metabolic process;GO:0030097,biological_process hemopoiesis;GO:0046872,molecular_function metal ion binding;GO:0071704,biological_process organic substance metabolic process	PGM3; phosphoacetylglucosamine mutase [EC:5.4.2.3]; K01836	phosphoglucomutase 3 [Source:HGNC Symbol%3BAcc:HGNC:8907]
ENSG00000166796	3.55	2.97	4.51	3.68	4.26	5.08	-0.216410875044182	2.06584965785265	0.272495700466038	0.657049170529318	11:18412306-18452058:+	LDHC	20;GO:0003824,molecular_function catalytic activity;GO:0004459,molecular_function L-lactate dehydrogenase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0005975,biological_process carbohydrate metabolic process;GO:0006090,biological_process pyruvate metabolic process;GO:0006754,biological_process ATP biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019244,biological_process lactate biosynthetic process from pyruvate;GO:0019516,biological_process lactate oxidation;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]; K00016	lactate dehydrogenase C [Source:HGNC Symbol%3BAcc:HGNC:6544]
ENSG00000157181	18.10	15.79	16.75	18.14	18.99	17.55	-0.0927758555114418	4.59208814755016	0.272613863012967	0.657206424855304	1:186375837-186421378:+	C1orf27	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 1 open reading frame 27 [Source:HGNC Symbol%3BAcc:HGNC:24299]
ENSG00000196943	12.97	14.80	13.60	14.85	13.61	16.12	-0.102569327920148	4.78265477516392	0.272738484988153	0.657379187215134	14:24299861-24309124:+	NOP9	3;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	NOP9 nucleolar protein [Source:HGNC Symbol%3BAcc:HGNC:19826]
ENSG00000130311	84.24	85.57	77.93	87.11	91.21	87.32	-0.0911848037813021	4.71929280263162	0.272842717643604	0.657422447937765	19:17309517-17323301:+	DDA1	4;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	DET1 and DDB1 associated 1 [Source:HGNC Symbol%3BAcc:HGNC:28360]
ENSG00000059122	21.45	20.32	21.00	21.17	18.67	20.19	0.0774096491099972	5.80038823187219	0.272862358154787	0.657422447937765	16:2911936-2951208:+	FLYWCH1	3;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0046872,molecular_function metal ion binding	NA	FLYWCH-type zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:25404]
ENSG00000055483	13.22	12.11	12.31	13.83	12.70	13.55	-0.0769409073586375	5.55268194711712	0.272922686617345	0.657440191923367	17:78787380-78841441:-	USP36	14;GO:0003723,molecular_function RNA binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	ubiquitin specific peptidase 36 [Source:HGNC Symbol%3BAcc:HGNC:20062]
ENSG00000111144	54.85	58.93	54.55	60.99	56.80	60.58	-0.0735518550067373	6.79616172014427	0.273092855242519	0.657722470338646	12:96000827-96043520:-	LTA4H	27;GO:0003723,molecular_function RNA binding;GO:0004177,molecular_function aminopeptidase activity;GO:0004301,molecular_function epoxide hydrolase activity;GO:0004463,molecular_function leukotriene-A4 hydrolase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006691,biological_process leukotriene metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0019370,biological_process leukotriene biosynthetic process;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0044255,biological_process cellular lipid metabolic process;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	LTA4H; leukotriene-A4 hydrolase [EC:3.3.2.6]; K01254	leukotriene A4 hydrolase [Source:HGNC Symbol%3BAcc:HGNC:6710]
ENSG00000148090	32.15	27.44	29.31	27.68	28.04	28.63	0.0930905038792506	4.88631696760605	0.273172438965722	0.657786515010961	9:91213814-91361913:-	AUH	12;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0003824,molecular_function catalytic activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0004490,molecular_function methylglutaconyl-CoA hydratase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006552,biological_process leucine catabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016829,molecular_function lyase activity	AUH; methylglutaconyl-CoA hydratase [EC:4.2.1.18]; K05607	AU RNA binding methylglutaconyl-CoA hydratase [Source:HGNC Symbol%3BAcc:HGNC:890]
ENSG00000133048	1.97	2.33	1.60	1.37	2.11	1.29	0.306756677841549	1.11651293972925	0.273237868992894	0.657816460009463	1:203178930-203186749:-	CHI3L1	29;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005975,biological_process carbohydrate metabolic process;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0008061,molecular_function chitin binding;GO:0009612,biological_process response to mechanical stimulus;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0030246,molecular_function carbohydrate binding;GO:0030324,biological_process lung development;GO:0034612,biological_process response to tumor necrosis factor;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051216,biological_process cartilage development;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070555,biological_process response to interleukin-1;GO:0070741,biological_process response to interleukin-6;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0072606,biological_process interleukin-8 secretion	E3.2.1.14; chitinase [EC:3.2.1.14]; K01183	chitinase 3 like 1 [Source:HGNC Symbol%3BAcc:HGNC:1932]
ENSG00000112699	14.65	16.27	11.55	14.67	18.15	14.46	-0.149288632459409	4.08587331575969	0.273385690547001	0.657956029281033	6:1623805-2245692:-	GMDS	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007219,biological_process Notch signaling pathway;GO:0008446,molecular_function GDP-mannose 4,6-dehydratase activity;GO:0016829,molecular_function lyase activity;GO:0019673,biological_process GDP-mannose metabolic process;GO:0042351,biological_process 'de novo' GDP-L-fucose biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0070062,cellular_component extracellular exosome;GO:0070401,molecular_function NADP+ binding	gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47]; K01711	GDP-mannose 4%2C6-dehydratase [Source:HGNC Symbol%3BAcc:HGNC:4369]
ENSG00000167720	50.75	43.00	50.58	50.65	54.50	49.64	-0.0836466301833757	5.67588007048405	0.27340185281814	0.657956029281033	17:2303382-2325260:+	SRR	34;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0003941,molecular_function L-serine ammonia-lyase activity;GO:0005509,molecular_function calcium ion binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006563,biological_process L-serine metabolic process;GO:0007420,biological_process brain development;GO:0007568,biological_process aging;GO:0008152,biological_process metabolic process;GO:0008721,molecular_function D-serine ammonia-lyase activity;GO:0009069,biological_process serine family amino acid metabolic process;GO:0014070,biological_process response to organic cyclic compound;GO:0016594,molecular_function glycine binding;GO:0016829,molecular_function lyase activity;GO:0016853,molecular_function isomerase activity;GO:0018114,molecular_function threonine racemase activity;GO:0030165,molecular_function PDZ domain binding;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030378,molecular_function serine racemase activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0042866,biological_process pyruvate biosynthetic process;GO:0043025,cellular_component neuronal cell body;GO:0043278,biological_process response to morphine;GO:0045177,cellular_component apical part of cell;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0070178,biological_process D-serine metabolic process;GO:0070179,biological_process D-serine biosynthetic process	SRR; serine racemase [EC:5.1.1.18]; K12235	serine racemase [Source:HGNC Symbol%3BAcc:HGNC:14398]
ENSG00000111907	115.50	110.67	113.34	111.90	104.45	109.82	0.0704799078883094	6.15182473555997	0.27351471182648	0.658100042237274	6:125119048-125264407:+	TPD52L1	10;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	tumor protein D52 like 1 [Source:HGNC Symbol%3BAcc:HGNC:12006]
ENSG00000073598	5.89	3.83	3.94	3.24	3.90	4.56	0.246203557413176	2.1007616030603	0.273627803861368	0.658125367703454	17:35121578-35130732:+	FNDC8	1;GO:0005634,cellular_component nucleus	NA	fibronectin type III domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:25286]
ENSG00000119689	66.42	67.48	72.96	74.00	71.55	73.79	-0.0723007214599814	6.61657598542627	0.273729416216151	0.658125367703454	14:74881890-74903745:+	DLST	16;GO:0004149,molecular_function dihydrolipoyllysine-residue succinyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006554,biological_process lysine catabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0033512,biological_process L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0043209,cellular_component myelin sheath;GO:0045252,cellular_component oxoglutarate dehydrogenase complex;GO:0070062,cellular_component extracellular exosome	DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]; K00658	dihydrolipoamide S-succinyltransferase [Source:HGNC Symbol%3BAcc:HGNC:2911]
ENSG00000102103	44.87	49.28	44.80	45.57	43.05	43.48	0.08017534879352	5.22960286244864	0.273740425496768	0.658125367703454	X:48897911-48903143:+	PQBP1	21;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016607,cellular_component nuclear speck;GO:0031175,biological_process neuron projection development;GO:0034063,biological_process stress granule assembly;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043484,biological_process regulation of RNA splicing;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0071598,cellular_component neuronal ribonucleoprotein granule	PQBP1, NPW38; polyglutamine-binding protein 1; K12865	polyglutamine binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9330]
ENSG00000105953	42.53	45.38	43.38	41.40	42.42	42.44	0.0673244573845961	7.13988526037109	0.273766234930865	0.658125367703454	7:44606571-44709066:+	OGDH	29;GO:0004591,molecular_function oxoglutarate dehydrogenase (succinyl-transferring) activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006096,biological_process glycolytic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006104,biological_process succinyl-CoA metabolic process;GO:0006554,biological_process lysine catabolic process;GO:0006734,biological_process NADH metabolic process;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016624,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;GO:0021695,biological_process cerebellar cortex development;GO:0021756,biological_process striatum development;GO:0021766,biological_process hippocampus development;GO:0021794,biological_process thalamus development;GO:0021860,biological_process pyramidal neuron development;GO:0022028,biological_process tangential migration from the subventricular zone to the olfactory bulb;GO:0030976,molecular_function thiamine pyrophosphate binding;GO:0031072,molecular_function heat shock protein binding;GO:0031966,cellular_component mitochondrial membrane;GO:0034602,molecular_function oxoglutarate dehydrogenase (NAD+) activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0045252,cellular_component oxoglutarate dehydrogenase complex;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0055114,biological_process oxidation-reduction process;GO:0061034,biological_process olfactory bulb mitral cell layer development	OGDH, sucA; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]; K00164	oxoglutarate dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:8124]
ENSG00000023228	44.33	50.37	46.96	49.58	50.26	50.40	-0.0751572437350562	6.7669002630039	0.273802523239664	0.658125367703454	2:206114816-206159603:-	NDUFS1	27;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0042773,biological_process ATP synthesis coupled electron transport;GO:0043209,cellular_component myelin sheath;GO:0045333,biological_process cellular respiration;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:0072593,biological_process reactive oxygen species metabolic process	NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2 1.6.99.3]; K03934	NADH:ubiquinone oxidoreductase core subunit S1 [Source:HGNC Symbol%3BAcc:HGNC:7707]
ENSG00000136108	31.65	30.55	30.51	32.57	35.73	30.52	-0.0789654228295257	6.04016405135024	0.273843351662639	0.658125367703454	13:52455428-52476628:+	CKAP2	14;GO:0000281,biological_process mitotic cytokinesis;GO:0000922,cellular_component spindle pole;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006915,biological_process apoptotic process;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007049,biological_process cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	cytoskeleton associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1990]
ENSG00000145012	7.19	7.25	6.68	7.98	7.64	7.39	-0.113867129375246	3.80981171961916	0.273918624107493	0.658178838762353	3:188153283-188890671:+	LPP	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0046872,molecular_function metal ion binding	LPP; lipoma-prefererred partner; K16676	LIM domain containing preferred translocation partner in lipoma [Source:HGNC Symbol%3BAcc:HGNC:6679]
ENSG00000258677	2.34	1.58	2.90	3.41	2.51	3.06	-0.353130404479206	0.529176740391346	0.274213607526366	0.658599786672569	8:73688690-73878854:-	AC022826.2	6;GO:0000209,biological_process protein polyubiquitination;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	NA
ENSG00000185838	8.44	6.00	6.49	8.72	7.84	7.34	-0.164940740136039	2.92141280649893	0.274223269779923	0.658599786672569	22:19783223-19854939:-	GNB1L	6;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0035176,biological_process social behavior;GO:0035556,biological_process intracellular signal transduction	NA	G protein subunit beta 1 like [Source:HGNC Symbol%3BAcc:HGNC:4397]
ENSG00000197536	4.27	3.52	5.12	6.36	3.18	6.19	-0.2664214933917	2.28329102871665	0.274262247630251	0.658599786672569	5:132410635-132488702:+	C5orf56	NA	NA	chromosome 5 open reading frame 56 [Source:HGNC Symbol%3BAcc:HGNC:33838]
ENSG00000071537	37.88	39.16	38.95	37.31	36.75	37.42	0.0682810962488722	6.50697281956007	0.274320263766162	0.658599786672569	14:81471548-81533861:-	SEL1L	19;GO:0000836,cellular_component Hrd1p ubiquitin ligase complex;GO:0000839,cellular_component Hrd1p ubiquitin ligase ERAD-L complex;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006641,biological_process triglyceride metabolic process;GO:0007219,biological_process Notch signaling pathway;GO:0009306,biological_process protein secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0050821,biological_process protein stabilization;GO:0055085,biological_process transmembrane transport;GO:1904380,biological_process endoplasmic reticulum mannose trimming	SEL1, SEL1L; SEL1 protein; K14026	SEL1L ERAD E3 ligase adaptor subunit [Source:HGNC Symbol%3BAcc:HGNC:10717]
ENSG00000188312	2.38	3.32	3.20	2.52	2.64	2.29	0.254310799744654	1.39901108437338	0.274376152670211	0.658599786672569	9:92325483-92620533:+	CENPP	9;GO:0000775,cellular_component chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0034080,biological_process CENP-A containing nucleosome assembly	NA	centromere protein P [Source:HGNC Symbol%3BAcc:HGNC:32933]
ENSG00000105732	6.11	6.17	5.85	5.80	5.74	5.49	0.100821584420043	4.1270221435668	0.274412156341781	0.658599786672569	19:42068476-42081549:+	ZNF574	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 574 [Source:HGNC Symbol%3BAcc:HGNC:26166]
ENSG00000174953	26.41	27.02	25.87	25.08	25.58	25.58	0.0675231138778147	6.29586188229334	0.274480627006807	0.658636772286003	3:154272545-154324497:-	DHX36	38;GO:0000166,molecular_function nucleotide binding;GO:0000781,cellular_component chromosome, telomeric region;GO:0001047,molecular_function core promoter binding;GO:0001503,biological_process ossification;GO:0002151,molecular_function G-quadruplex RNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0009615,biological_process response to virus;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0032481,biological_process positive regulation of type I interferon production;GO:0042826,molecular_function histone deacetylase binding;GO:0043330,biological_process response to exogenous dsRNA;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051880,molecular_function G-quadruplex DNA binding;GO:0070034,molecular_function telomerase RNA binding;GO:0070062,cellular_component extracellular exosome;GO:0090669,biological_process telomerase RNA stabilization;GO:1902741,biological_process positive regulation of interferon-alpha secretion	DHX36, RHAU; ATP-dependent RNA helicase DHX36 [EC:3.6.4.13]; K14442	DEAH-box helicase 36 [Source:HGNC Symbol%3BAcc:HGNC:14410]
ENSG00000143942	7.29	4.33	5.47	5.43	3.43	5.48	0.280942239622992	1.62043070009229	0.275039417567602	0.659757581536273	2:53767791-53775196:+	CHAC2	10;GO:0003674,molecular_function molecular_function;GO:0003839,molecular_function gamma-glutamylcyclotransferase activity;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006750,biological_process glutathione biosynthetic process;GO:0006751,biological_process glutathione catabolic process;GO:0008150,biological_process biological_process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups	NA	ChaC cation transport regulator homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:32363]
ENSG00000170502	46.34	48.42	46.12	49.56	53.02	47.28	-0.0784394499611655	5.67365125122867	0.275082623827403	0.659757581536273	4:87422581-87459454:+	NUDT9	13;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0016787,molecular_function hydrolase activity;GO:0019144,molecular_function ADP-sugar diphosphatase activity;GO:0030054,cellular_component cell junction;GO:0031965,cellular_component nuclear membrane;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0043262,molecular_function adenosine-diphosphatase activity;GO:0046032,biological_process ADP catabolic process;GO:0046709,biological_process IDP catabolic process;GO:0047631,molecular_function ADP-ribose diphosphatase activity;GO:0070062,cellular_component extracellular exosome	NUDT9; ADP-ribose pyrophosphatase [EC:3.6.1.13]; K13988	nudix hydrolase 9 [Source:HGNC Symbol%3BAcc:HGNC:8056]
ENSG00000102302	10.85	10.38	11.08	11.43	11.68	11.39	-0.0798529864300694	5.01361595674846	0.275107165232559	0.659757581536273	X:54445453-54496166:-	FGD1	23;GO:0001726,cellular_component ruffle;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008360,biological_process regulation of cell shape;GO:0009887,biological_process organ morphogenesis;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0031267,molecular_function small GTPase binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046847,biological_process filopodium assembly;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	FGD1; FYVE, RhoGEF and PH domain containing 1; K05720	FYVE%2C RhoGEF and PH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:3663]
ENSG00000134779	61.62	65.32	54.22	61.15	68.36	64.15	-0.0862646790654857	6.60988771121685	0.275225331266652	0.659913470545287	18:36777646-36829216:-	TPGS2	3;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule	NA	tubulin polyglutamylase complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:24561]
ENSG00000056736	2.67	3.93	3.42	3.03	2.87	2.80	0.198230228069757	2.26582035816601	0.275286381448823	0.659932377930522	3:53846579-53865800:+	IL17RB	16;GO:0001558,biological_process regulation of cell growth;GO:0004896,molecular_function cytokine receptor activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006952,biological_process defense response;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030368,molecular_function interleukin-17 receptor activity;GO:0050729,biological_process positive regulation of inflammatory response;GO:0097398,biological_process cellular response to interleukin-17;GO:2000664,biological_process positive regulation of interleukin-5 secretion;GO:2000667,biological_process positive regulation of interleukin-13 secretion	IL17RB, IL17RH1; interleukin 17 receptor B; K05165	interleukin 17 receptor B [Source:HGNC Symbol%3BAcc:HGNC:18015]
ENSG00000268750	1.74	1.52	1.38	1.51	0.99	0.91	0.456194261995792	0.106869941491615	0.275647866831203	0.660671359524179	19:57819718-57858941:+	AC010522.1	3;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated	KRAB; KRAB domain-containing zinc finger protein; K09228	NA
ENSG00000130758	6.12	4.98	5.91	6.25	6.62	5.77	-0.11021937419798	4.10698441023875	0.275743909767332	0.66077396755635	19:40191743-40215575:+	MAP3K10	34;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004706,molecular_function JUN kinase kinase kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007224,biological_process smoothened signaling pathway;GO:0007254,biological_process JNK cascade;GO:0007256,biological_process activation of JNKK activity;GO:0007257,biological_process activation of JUN kinase activity;GO:0008219,biological_process cell death;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation	NA	mitogen-activated protein kinase kinase kinase 10 [Source:HGNC Symbol%3BAcc:HGNC:6849]
ENSG00000135801	8.34	8.90	7.13	7.61	9.76	9.50	-0.135581217102121	4.01751667760561	0.275935734361467	0.661106016334469	1:229593110-229626047:-	TAF5L	13;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016607,cellular_component nuclear speck;GO:0030914,cellular_component STAGA complex;GO:0033276,cellular_component transcription factor TFTC complex;GO:0043966,biological_process histone H3 acetylation	TAF5; transcription initiation factor TFIID subunit 5; K03130	TATA-box binding protein associated factor 5 like [Source:HGNC Symbol%3BAcc:HGNC:17304]
ENSG00000175224	26.02	24.74	27.12	28.39	28.58	26.12	-0.0780995775311589	5.50103726883736	0.276185000906057	0.661416626986957	11:46617526-46674818:+	ATG13	15;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000423,biological_process macromitophagy;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0019901,molecular_function protein kinase binding;GO:0098780,biological_process response to mitochondrial depolarisation;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1990316,cellular_component ATG1/ULK1 kinase complex	NA	autophagy related 13 [Source:HGNC Symbol%3BAcc:HGNC:29091]
ENSG00000112144	4.92	5.29	6.02	4.54	5.24	5.04	0.142198290287415	3.31625429277206	0.276188528615816	0.661416626986957	6:53001278-53061802:-	ICK	29;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030030,biological_process cell projection organization;GO:0035556,biological_process intracellular signal transduction;GO:0035720,biological_process intraciliary anterograde transport;GO:0035721,biological_process intraciliary retrograde transport;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base	NA	intestinal cell kinase [Source:HGNC Symbol%3BAcc:HGNC:21219]
ENSG00000056586	10.98	11.75	11.93	11.33	12.41	13.27	-0.0847898889971859	5.55177403845315	0.276225231152855	0.661416626986957	9:122844555-122905341:-	RC3H2	25;GO:0000209,biological_process protein polyubiquitination;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001782,biological_process B cell homeostasis;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0009791,biological_process post-embryonic development;GO:0009986,cellular_component cell surface;GO:0010468,biological_process regulation of gene expression;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0035264,biological_process multicellular organism growth;GO:0042098,biological_process T cell proliferation;GO:0043029,biological_process T cell homeostasis;GO:0046872,molecular_function metal ion binding;GO:0048286,biological_process lung alveolus development;GO:0048535,biological_process lymph node development;GO:0048536,biological_process spleen development;GO:0060173,biological_process limb development;GO:0061470,biological_process T follicular helper cell differentiation;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling	NA	ring finger and CCCH-type domains 2 [Source:HGNC Symbol%3BAcc:HGNC:21461]
ENSG00000215883	2.21	1.99	2.37	3.55	2.66	1.93	-0.282930063656198	1.45858482807102	0.276279801669693	0.661419706485226	1:54169650-54200036:-	CYB5RL	5;GO:0004128,molecular_function cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0015701,biological_process bicarbonate transport;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome b5 reductase like [Source:HGNC Symbol%3BAcc:HGNC:32220]
ENSG00000185482	1.94	1.75	2.43	1.71	1.67	1.67	0.298623951846049	1.13168552282156	0.276388216661294	0.661551664754463	12:57243452-57251193:-	STAC3	9;GO:0003009,biological_process skeletal muscle contraction;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0048741,biological_process skeletal muscle fiber development	NA	SH3 and cysteine rich domain 3 [Source:HGNC Symbol%3BAcc:HGNC:28423]
ENSG00000127311	0.86	0.99	1.12	1.40	1.23	0.92	-0.23665221467844	1.89233450009976	0.276549285831705	0.661770631321826	12:66302544-66347645:+	HELB	24;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005658,cellular_component alpha DNA polymerase:primase complex;GO:0005662,cellular_component DNA replication factor A complex;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006269,biological_process DNA replication, synthesis of RNA primer;GO:0006281,biological_process DNA repair;GO:0006396,biological_process RNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016787,molecular_function hydrolase activity;GO:0017116,molecular_function single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0035861,cellular_component site of double-strand break;GO:0043141,molecular_function ATP-dependent 5'-3' DNA helicase activity;GO:1903775,biological_process regulation of DNA double-strand break processing;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination	NA	DNA helicase B [Source:HGNC Symbol%3BAcc:HGNC:17196]
ENSG00000214510	5.01	6.78	4.18	3.98	4.03	4.24	0.360414125088431	0.543773652992899	0.276651654161816	0.661770631321826	5:148268179-148286254:+	SPINK13	9;GO:0001669,cellular_component acrosomal vesicle;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0010466,biological_process negative regulation of peptidase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0060046,biological_process regulation of acrosome reaction;GO:1900004,biological_process negative regulation of serine-type endopeptidase activity;GO:1902225,biological_process negative regulation of acrosome reaction	NA	serine peptidase inhibitor%2C Kazal type 13 (putative) [Source:HGNC Symbol%3BAcc:HGNC:27200]
ENSG00000132781	4.95	5.18	4.90	5.42	5.32	5.88	-0.138920737917832	3.18869662079595	0.276656212101365	0.661770631321826	1:45329162-45340470:-	MUTYH	20;GO:0000701,molecular_function purine-specific mismatch base pair DNA N-glycosylase activity;GO:0003677,molecular_function DNA binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0032407,molecular_function MutSalpha complex binding;GO:0045007,biological_process depurination;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding	mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]; K03575	mutY DNA glycosylase [Source:HGNC Symbol%3BAcc:HGNC:7527]
ENSG00000154370	9.31	9.15	10.15	8.77	8.84	9.27	0.104136345345699	4.09357493488611	0.276741188268976	0.661770631321826	1:228393672-228406840:-	TRIM11	21;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019904,molecular_function protein domain specific binding;GO:0032897,biological_process negative regulation of viral transcription;GO:0045087,biological_process innate immune response;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046598,biological_process positive regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0050768,biological_process negative regulation of neurogenesis;GO:0051607,biological_process defense response to virus;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1902187,biological_process negative regulation of viral release from host cell	NA	tripartite motif containing 11 [Source:HGNC Symbol%3BAcc:HGNC:16281]
ENSG00000008441	15.94	12.72	14.74	13.46	13.49	13.91	0.10747377364777	4.51125127057868	0.276783759621869	0.661770631321826	19:12995607-13098796:+	NFIX	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	nuclear factor I X [Source:HGNC Symbol%3BAcc:HGNC:7788]
ENSG00000143412	2.39	1.94	2.49	3.04	2.64	2.51	-0.234951180200552	1.46456648450023	0.276838844511809	0.661770631321826	1:150982016-150995634:+	ANXA9	12;GO:0001786,molecular_function phosphatidylserine binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0015464,molecular_function acetylcholine receptor activity;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0042803,molecular_function protein homodimerization activity;GO:0070062,cellular_component extracellular exosome	NA	annexin A9 [Source:HGNC Symbol%3BAcc:HGNC:547]
ENSG00000197013	4.61	4.27	4.08	3.76	4.17	3.99	0.134347631100212	3.29367447323036	0.276909186090493	0.661770631321826	19:21496681-21556270:+	ZNF429	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 429 [Source:HGNC Symbol%3BAcc:HGNC:20817]
ENSG00000211455	6.66	6.90	6.15	7.21	7.05	7.43	-0.131443955646796	3.38894195240709	0.276949489089929	0.661770631321826	12:27243967-27325959:+	STK38L	20;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003779,molecular_function actin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:0051128,biological_process regulation of cellular component organization	NA	serine/threonine kinase 38 like [Source:HGNC Symbol%3BAcc:HGNC:17848]
ENSG00000097046	9.52	8.16	8.46	7.96	9.95	11.11	-0.136187416189706	4.00437557884107	0.276959512584942	0.661770631321826	1:91500892-91525764:+	CDC7	28;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000727,biological_process double-strand break repair via break-induced replication;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006468,biological_process protein phosphorylation;GO:0006909,biological_process phagocytosis;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0010571,biological_process positive regulation of nuclear cell cycle DNA replication;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0044770,biological_process cell cycle phase transition;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0072686,cellular_component mitotic spindle	CDC7; cell division control protein 7 [EC:2.7.11.1]; K02214	cell division cycle 7 [Source:HGNC Symbol%3BAcc:HGNC:1745]
ENSG00000111321	108.41	104.51	107.83	96.72	109.80	101.12	0.0725789713122416	7.24204567731052	0.277040538664049	0.66183683726652	12:6375044-6391571:+	LTBR	23;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048534,biological_process hematopoietic or lymphoid organ development;GO:0071260,biological_process cellular response to mechanical stimulus;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3; K03159	lymphotoxin beta receptor [Source:HGNC Symbol%3BAcc:HGNC:6718]
ENSG00000125898	2.95	2.59	2.58	3.05	3.60	3.10	-0.242353295839662	1.48463922397467	0.277227899903947	0.662084747457763	20:833714-857463:+	FAM110A	5;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton	NA	family with sequence similarity 110 member A [Source:HGNC Symbol%3BAcc:HGNC:16188]
ENSG00000065357	6.22	5.79	6.57	7.53	6.49	6.30	-0.112353197449771	4.02225520670836	0.277295549906962	0.662084747457763	12:55927318-55954027:+	DGKA	22;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005524,molecular_function ATP binding;GO:0005543,molecular_function phospholipid binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030168,biological_process platelet activation;GO:0035556,biological_process intracellular signal transduction;GO:0046339,biological_process diacylglycerol metabolic process;GO:0046486,biological_process glycerolipid metabolic process;GO:0046834,biological_process lipid phosphorylation;GO:0046872,molecular_function metal ion binding	dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]; K00901	diacylglycerol kinase alpha [Source:HGNC Symbol%3BAcc:HGNC:2849]
ENSG00000225697	16.40	16.13	16.75	15.07	14.89	16.97	0.0818693048415101	5.27264636974466	0.277350702645762	0.662084747457763	3:48625722-48635493:-	SLC26A6	56;GO:0005254,molecular_function chloride channel activity;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0006821,biological_process chloride transport;GO:0008271,molecular_function secondary active sulfate transmembrane transporter activity;GO:0008272,biological_process sulfate transport;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0012506,cellular_component vesicle membrane;GO:0015106,molecular_function bicarbonate transmembrane transporter activity;GO:0015108,molecular_function chloride transmembrane transporter activity;GO:0015116,molecular_function sulfate transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015499,molecular_function formate transmembrane transporter activity;GO:0015562,molecular_function efflux transmembrane transporter activity;GO:0015659,molecular_function formate uptake transmembrane transporter activity;GO:0015660,molecular_function formate efflux transmembrane transporter activity;GO:0015701,biological_process bicarbonate transport;GO:0015724,biological_process formate transport;GO:0015797,biological_process mannitol transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019531,molecular_function oxalate transmembrane transporter activity;GO:0019532,biological_process oxalate transport;GO:0030165,molecular_function PDZ domain binding;GO:0030321,biological_process transepithelial chloride transport;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031526,cellular_component brush border membrane;GO:0031982,cellular_component vesicle;GO:0034707,cellular_component chloride channel complex;GO:0042045,biological_process epithelial fluid transport;GO:0042391,biological_process regulation of membrane potential;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046724,biological_process oxalic acid secretion;GO:0048240,biological_process sperm capacitation;GO:0050892,biological_process intestinal absorption;GO:0051453,biological_process regulation of intracellular pH;GO:0051454,biological_process intracellular pH elevation;GO:0055085,biological_process transmembrane transport;GO:0070633,biological_process transepithelial transport;GO:0071320,biological_process cellular response to cAMP;GO:0071332,biological_process cellular response to fructose stimulus;GO:0071346,biological_process cellular response to interferon-gamma;GO:0097225,cellular_component sperm midpiece;GO:0098656,biological_process anion transmembrane transport;GO:1902358,biological_process sulfate transmembrane transport;GO:1902476,biological_process chloride transmembrane transport;GO:2001150,biological_process positive regulation of dipeptide transmembrane transport	SLC26A6; solute carrier family 26 (sulfate anion transporter), member 6; K14704	solute carrier family 26 member 6 [Source:HGNC Symbol%3BAcc:HGNC:14472]
ENSG00000134077	28.31	28.82	27.66	27.70	25.81	27.54	0.0750650470894347	5.39988444184376	0.277369772550807	0.662084747457763	3:9362841-9386791:+	THUMPD3	8;GO:0003723,molecular_function RNA binding;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0008168,molecular_function methyltransferase activity;GO:0016423,molecular_function tRNA (guanine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	THUMP domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:24493]
ENSG00000144827	15.35	17.48	17.15	19.32	16.56	18.52	-0.116271221854439	4.07054174075699	0.277411002298222	0.662084747457763	3:111979009-111993363:+	ABHD10	8;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0016787,molecular_function hydrolase activity;GO:0019391,biological_process glucuronoside catabolic process;GO:0052695,biological_process cellular glucuronidation;GO:0102390,molecular_function mycophenolic acid acyl-glucuronide esterase activity	NA	abhydrolase domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:25656]
ENSG00000148225	8.47	7.03	7.62	6.80	7.99	6.13	0.166429533474068	3.04360191082405	0.277468550580631	0.662094793994113	9:113313221-113340298:-	WDR31	NA	NA	WD repeat domain 31 [Source:HGNC Symbol%3BAcc:HGNC:21421]
ENSG00000131626	18.72	18.39	19.72	18.04	18.96	17.56	0.0721953723726341	6.2777901701619	0.277714966373927	0.662367791771208	11:70270699-70384403:+	PPFIA1	14;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007165,biological_process signal transduction;GO:0007269,biological_process neurotransmitter secretion;GO:0014047,biological_process glutamate secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0048786,cellular_component presynaptic active zone;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0090005,biological_process negative regulation of establishment of protein localization to plasma membrane	NA	PTPRF interacting protein alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:9245]
ENSG00000139921	111.78	107.38	103.01	111.37	112.82	116.97	-0.0709294018529202	6.54234180337125	0.277764078851032	0.662367791771208	14:51240161-51257546:+	TMX1	11;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0015036,molecular_function disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process	NA	thioredoxin related transmembrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15487]
ENSG00000186073	6.63	6.96	5.98	8.37	6.24	7.64	-0.180548671435448	2.75778942964928	0.277804819195115	0.662367791771208	15:36579610-36810248:+	C15orf41	NA	NA	chromosome 15 open reading frame 41 [Source:HGNC Symbol%3BAcc:HGNC:26929]
ENSG00000100068	3.62	4.90	3.29	3.35	3.19	3.33	0.245623438369195	1.51918702763635	0.277835965331731	0.662367791771208	22:25351417-25405377:-	LRP5L	NA	NA	LDL receptor related protein 5 like [Source:HGNC Symbol%3BAcc:HGNC:25323]
ENSG00000027001	7.66	7.77	7.50	7.11	7.91	6.31	0.117729196519358	3.99161930697138	0.27788432584002	0.662367791771208	13:23730188-23889419:-	MIPEP	10;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006508,biological_process proteolysis;GO:0006518,biological_process peptide metabolic process;GO:0006627,biological_process protein processing involved in protein targeting to mitochondrion;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	mitochondrial intermediate peptidase [Source:HGNC Symbol%3BAcc:HGNC:7104]
ENSG00000153827	47.34	46.99	44.71	48.36	48.50	49.64	-0.0637879088202788	8.21134234240895	0.278032570845353	0.662367791771208	2:229763837-229923239:-	TRIP12	18;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009790,biological_process embryo development;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1901315,biological_process negative regulation of histone H2A K63-linked ubiquitination;GO:2000780,biological_process negative regulation of double-strand break repair	TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]; K10590	thyroid hormone receptor interactor 12 [Source:HGNC Symbol%3BAcc:HGNC:12306]
ENSG00000204611	7.07	6.34	7.16	6.02	6.97	6.23	0.117028292291074	4.02414918533164	0.278052531861224	0.662367791771208	19:52113090-52139922:-	ZNF616	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 616 [Source:HGNC Symbol%3BAcc:HGNC:28062]
ENSG00000121897	13.86	12.98	14.54	15.96	13.95	14.89	-0.0990705782107396	4.41710531558058	0.278063572940465	0.662367791771208	4:39458586-39485109:+	LIAS	16;GO:0001843,biological_process neural tube closure;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006954,biological_process inflammatory response;GO:0006979,biological_process response to oxidative stress;GO:0009107,biological_process lipoate biosynthetic process;GO:0009249,biological_process protein lipoylation;GO:0016740,molecular_function transferase activity;GO:0016783,molecular_function sulfurtransferase activity;GO:0016992,molecular_function lipoate synthase activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding	lipA, LIAS, LIP1, LIP5; lipoyl synthase [EC:2.8.1.8]; K03644	lipoic acid synthetase [Source:HGNC Symbol%3BAcc:HGNC:16429]
ENSG00000176225	1.72	1.57	1.79	2.02	1.86	1.72	-0.121869142451224	3.63699436730097	0.278115010121322	0.662367791771208	18:70003030-70205945:-	RTTN	11;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0044782,biological_process cilium organization	NA	rotatin [Source:HGNC Symbol%3BAcc:HGNC:18654]
ENSG00000164647	17.19	14.32	18.18	15.30	11.85	18.07	0.151329914143252	4.14154469169127	0.278116565754575	0.662367791771208	7:90154374-90164829:+	STEAP1	15;GO:0005215,molecular_function transporter activity;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006811,biological_process ion transport;GO:0010008,cellular_component endosome membrane;GO:0015267,molecular_function channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0055072,biological_process iron ion homeostasis;GO:0055085,biological_process transmembrane transport;GO:0055114,biological_process oxidation-reduction process	STEAP1; metalloreductase STEAP1 [EC:1.16.1.-]; K14737	STEAP family member 1 [Source:HGNC Symbol%3BAcc:HGNC:11378]
ENSG00000129084	87.11	79.05	74.15	86.89	81.27	87.94	-0.0795221301361499	6.07136706719539	0.278183337265796	0.662399724818785	11:14504873-14643635:-	PSMA1	44;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003723,molecular_function RNA binding;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0005844,cellular_component polysome;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019773,cellular_component proteasome core complex, alpha-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMA1; 20S proteasome subunit alpha 6 [EC:3.4.25.1]; K02725	proteasome subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:9530]
ENSG00000124214	63.61	64.46	62.95	67.06	68.76	65.90	-0.0672504794906114	6.90777681129841	0.278245616804176	0.662420951551638	20:49113338-49188367:-	STAU1	22;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0030425,cellular_component dendrite;GO:0034599,biological_process cellular response to oxidative stress;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0044297,cellular_component cell body;GO:0045070,biological_process positive regulation of viral genome replication;GO:0046726,biological_process positive regulation by virus of viral protein levels in host cell;GO:0070062,cellular_component extracellular exosome;GO:1900273,biological_process positive regulation of long-term synaptic potentiation	NA	staufen double-stranded RNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11370]
ENSG00000169604	17.88	19.27	21.46	17.33	19.85	18.14	0.0953010285554876	5.13703244940784	0.278318812488553	0.662468153292505	2:69013177-69249327:+	ANTXR1	23;GO:0001568,biological_process blood vessel development;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022414,biological_process reproductive process;GO:0031258,cellular_component lamellipodium membrane;GO:0031527,cellular_component filopodium membrane;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome;GO:1901202,biological_process negative regulation of extracellular matrix assembly;GO:1905050,biological_process positive regulation of metallopeptidase activity	NA	anthrax toxin receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:21014]
ENSG00000131507	140.19	150.34	141.87	146.58	164.73	148.17	-0.076984191792977	6.62543639001259	0.278409779314906	0.662557628572839	5:142108504-142154443:+	NDFIP1	35;GO:0000139,cellular_component Golgi membrane;GO:0002761,biological_process regulation of myeloid leukocyte differentiation;GO:0002829,biological_process negative regulation of type 2 immune response;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005938,cellular_component cell cortex;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007034,biological_process vacuolar transport;GO:0007165,biological_process signal transduction;GO:0010008,cellular_component endosome membrane;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032410,biological_process negative regulation of transporter activity;GO:0032713,biological_process negative regulation of interleukin-4 production;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045202,cellular_component synapse;GO:0045619,biological_process regulation of lymphocyte differentiation;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0048294,biological_process negative regulation of isotype switching to IgE isotypes;GO:0048302,biological_process regulation of isotype switching to IgG isotypes;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050699,molecular_function WW domain binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051224,biological_process negative regulation of protein transport	NA	Nedd4 family interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17592]
ENSG00000127616	25.68	29.74	24.70	27.83	30.37	27.46	-0.0863208381315094	7.18032616791766	0.278546086977633	0.662721788447138	19:10961000-11065395:+	SMARCA4	59;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0002039,molecular_function p53 binding;GO:0003407,biological_process neural retina development;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006325,biological_process chromatin organization;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007070,biological_process negative regulation of transcription from RNA polymerase II promoter during mitosis;GO:0007399,biological_process nervous system development;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008134,molecular_function transcription factor binding;GO:0016020,cellular_component membrane;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0016887,molecular_function ATPase activity;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030308,biological_process negative regulation of cell growth;GO:0030957,molecular_function Tat protein binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042393,molecular_function histone binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047485,molecular_function protein N-terminus binding;GO:0050681,molecular_function androgen receptor binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0070182,molecular_function DNA polymerase binding;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1902661,biological_process positive regulation of glucose mediated signaling pathway;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	SMARCA2_4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 [EC:3.6.4.-]; K11647	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 4 [Source:HGNC Symbol%3BAcc:HGNC:11100]
ENSG00000188997	7.42	6.98	6.79	7.01	6.51	5.32	0.187119683906029	2.41912678818463	0.27863004954664	0.662721788447138	11:78171248-78188822:-	KCTD21	1;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 21 [Source:HGNC Symbol%3BAcc:HGNC:27452]
ENSG00000087206	15.65	15.39	16.76	18.26	16.67	16.24	-0.0839791667727468	5.16373910967328	0.278659988785858	0.662721788447138	5:176905004-177022633:-	UIMC1	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010212,biological_process response to ionizing radiation;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0042393,molecular_function histone binding;GO:0045739,biological_process positive regulation of DNA repair;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0070531,cellular_component BRCA1-A complex;GO:0070537,biological_process histone H2A K63-linked deubiquitination	NA	ubiquitin interaction motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30298]
ENSG00000147121	16.89	16.75	15.90	17.90	16.08	20.64	-0.132495529421269	3.69575157076735	0.278692317384521	0.662721788447138	X:46446856-46497422:+	KRBOX4	3;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	KRAB box domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:26007]
ENSG00000175416	16.11	20.79	17.30	16.73	17.92	15.05	0.127828965771787	3.8946275858794	0.278844582812694	0.662778155064922	5:176392454-176416569:-	CLTB	21;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006886,biological_process intracellular protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030118,cellular_component clathrin coat;GO:0030125,cellular_component clathrin vesicle coat;GO:0030130,cellular_component clathrin coat of trans-Golgi network vesicle;GO:0030132,cellular_component clathrin coat of coated pit;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032050,molecular_function clathrin heavy chain binding;GO:0042277,molecular_function peptide binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0060170,cellular_component ciliary membrane;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis	CLTB, LCB; clathrin light chain B; K04645	clathrin light chain B [Source:HGNC Symbol%3BAcc:HGNC:2091]
ENSG00000129657	55.00	49.50	53.86	61.75	50.78	56.82	-0.0840320895426992	6.96519102134285	0.278889098016951	0.662778155064922	17:77086715-77217101:+	SEC14L1	13;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0009968,biological_process negative regulation of signal transduction;GO:0015871,biological_process choline transport;GO:0016021,cellular_component integral component of membrane;GO:0039536,biological_process negative regulation of RIG-I signaling pathway;GO:0039552,molecular_function RIG-I binding;GO:0045087,biological_process innate immune response;GO:0065009,biological_process regulation of molecular function;GO:0098772,molecular_function molecular function regulator	NA	SEC14 like lipid binding 1 [Source:HGNC Symbol%3BAcc:HGNC:10698]
ENSG00000167815	225.91	240.04	228.86	214.66	224.08	229.07	0.0678629089573775	7.07781321498846	0.278926875505287	0.662778155064922	19:12796819-12801859:-	PRDX2	17;GO:0004601,molecular_function peroxidase activity;GO:0005623,cellular_component cell;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006979,biological_process response to oxidative stress;GO:0008379,molecular_function thioredoxin peroxidase activity;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019430,biological_process removal of superoxide radicals;GO:0034599,biological_process cellular response to oxidative stress;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045454,biological_process cell redox homeostasis;GO:0051920,molecular_function peroxiredoxin activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]; K03386	peroxiredoxin 2 [Source:HGNC Symbol%3BAcc:HGNC:9353]
ENSG00000174021	284.23	331.20	305.95	326.28	347.24	309.19	-0.0841321206323429	6.01944478172576	0.278942493538841	0.662778155064922	1:84498324-84506565:-	GNG5	15;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0030165,molecular_function PDZ domain binding;GO:0031680,cellular_component G-protein beta/gamma-subunit complex;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0072513,biological_process positive regulation of secondary heart field cardioblast proliferation;GO:2000179,biological_process positive regulation of neural precursor cell proliferation	GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; K04542	G protein subunit gamma 5 [Source:HGNC Symbol%3BAcc:HGNC:4408]
ENSG00000043093	28.90	30.75	28.89	30.45	33.19	31.40	-0.0937688303147362	4.58057038436949	0.278984144141157	0.662778155064922	3:182938073-182985953:-	DCUN1D1	11;GO:0000151,cellular_component ubiquitin ligase complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032182,molecular_function ubiquitin-like protein binding;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0097602,molecular_function cullin family protein binding	NA	defective in cullin neddylation 1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18184]
ENSG00000101161	45.03	44.21	42.50	47.98	46.21	45.11	-0.0687862976900686	6.99730629548395	0.279036384304301	0.662778155064922	20:63981134-64033100:+	PRPF6	22;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000245,biological_process spliceosomal complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006403,biological_process RNA localization;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0050681,molecular_function androgen receptor binding;GO:0071013,cellular_component catalytic step 2 spliceosome	PRPF6, PRP6; pre-mRNA-processing factor 6; K12855	pre-mRNA processing factor 6 [Source:HGNC Symbol%3BAcc:HGNC:15860]
ENSG00000120333	38.13	35.13	39.74	39.80	40.79	41.81	-0.0980058460981703	4.23894219630371	0.279207660189012	0.663050877734098	1:175010788-175023425:-	MRPS14	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14; K02954	mitochondrial ribosomal protein S14 [Source:HGNC Symbol%3BAcc:HGNC:14049]
ENSG00000180537	4.19	4.90	4.17	5.86	4.09	5.60	-0.230762496950206	1.89198804001857	0.279288502754916	0.663050877734098	6:13924445-13980302:+	RNF182	8;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 182 [Source:HGNC Symbol%3BAcc:HGNC:28522]
ENSG00000175215	46.15	41.93	52.65	50.85	49.82	50.63	-0.087821748527371	5.39133241779014	0.279384721409623	0.663050877734098	12:57819926-57846739:-	CTDSP2	13;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0008420,molecular_function CTD phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0046872,molecular_function metal ion binding;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	CTD small phosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:17077]
ENSG00000046653	2.78	1.70	1.86	1.97	3.77	2.31	-0.308395998729456	1.45098753160775	0.279390770155001	0.663050877734098	X:13771030-13938638:-	GPM6B	17;GO:0001503,biological_process ossification;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030501,biological_process positive regulation of bone mineralization;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0045121,cellular_component membrane raft;GO:0051612,biological_process negative regulation of serotonin uptake;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0085029,biological_process extracellular matrix assembly;GO:2000009,biological_process negative regulation of protein localization to cell surface	NA	glycoprotein M6B [Source:HGNC Symbol%3BAcc:HGNC:4461]
ENSG00000185920	2.78	2.50	2.60	2.63	2.27	2.39	0.127477790459509	3.5825907954505	0.279425478944776	0.663050877734098	9:95442979-95517057:-	PTCH1	85;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001709,biological_process cell fate determination;GO:0001841,biological_process neural tube formation;GO:0001843,biological_process neural tube closure;GO:0003007,biological_process heart morphogenesis;GO:0005113,molecular_function patched binding;GO:0005119,molecular_function smoothened binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005929,cellular_component cilium;GO:0007165,biological_process signal transduction;GO:0007224,biological_process smoothened signaling pathway;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007389,biological_process pattern specification process;GO:0007420,biological_process brain development;GO:0008158,molecular_function hedgehog receptor activity;GO:0008201,molecular_function heparin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008544,biological_process epidermis development;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0009612,biological_process response to mechanical stimulus;GO:0009887,biological_process organ morphogenesis;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009957,biological_process epidermal cell fate specification;GO:0010157,biological_process response to chlorate;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0014069,cellular_component postsynaptic density;GO:0014070,biological_process response to organic cyclic compound;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021532,biological_process neural tube patterning;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021997,biological_process neural plate axis specification;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030332,molecular_function cyclin binding;GO:0030496,cellular_component midbody;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030850,biological_process prostate gland development;GO:0030879,biological_process mammary gland development;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0032526,biological_process response to retinoic acid;GO:0032880,biological_process regulation of protein localization;GO:0035108,biological_process limb morphogenesis;GO:0035137,biological_process hindlimb morphogenesis;GO:0040008,biological_process regulation of growth;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0042593,biological_process glucose homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043616,biological_process keratinocyte proliferation;GO:0044294,cellular_component dendritic growth cone;GO:0044295,cellular_component axonal growth cone;GO:0045606,biological_process positive regulation of epidermal cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048568,biological_process embryonic organ development;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051782,biological_process negative regulation of cell division;GO:0060037,biological_process pharyngeal system development;GO:0060170,cellular_component ciliary membrane;GO:0060603,biological_process mammary gland duct morphogenesis;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0060831,biological_process smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0061005,biological_process cell differentiation involved in kidney development;GO:0061053,biological_process somite development;GO:0071397,biological_process cellular response to cholesterol;GO:0071679,biological_process commissural neuron axon guidance;GO:0072001,biological_process renal system development;GO:0072203,biological_process cell proliferation involved in metanephros development;GO:0072661,biological_process protein targeting to plasma membrane;GO:0097108,molecular_function hedgehog family protein binding	PTCH1; patched 1; K06225	patched 1 [Source:HGNC Symbol%3BAcc:HGNC:9585]
ENSG00000274512	4.20	3.37	3.35	3.41	2.67	3.59	0.192243931033898	2.54173332228564	0.279525169806626	0.663050877734098	17:37977971-37989048:-	TBC1D3L	9;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 3L [Source:HGNC Symbol%3BAcc:HGNC:51246]
ENSG00000161847	13.39	14.47	13.71	13.06	13.22	13.28	0.0796908596369406	5.00001673593756	0.279607483661387	0.663050877734098	19:10316211-10333640:-	RAVER1	5;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm	NA	ribonucleoprotein%2C PTB binding 1 [Source:HGNC Symbol%3BAcc:HGNC:30296]
ENSG00000139182	16.82	14.46	17.31	18.21	15.70	18.38	-0.0901943181015303	5.65545854943914	0.279611632486505	0.663050877734098	12:7129697-7158945:+	CLSTN3	22;GO:0000139,cellular_component Golgi membrane;GO:0001558,biological_process regulation of cell growth;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416,biological_process synapse assembly;GO:0009986,cellular_component cell surface;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0043234,cellular_component protein complex;GO:0045211,cellular_component postsynaptic membrane;GO:0050806,biological_process positive regulation of synaptic transmission;GO:0051932,biological_process synaptic transmission, GABAergic;GO:0051965,biological_process positive regulation of synapse assembly;GO:0070062,cellular_component extracellular exosome;GO:1902474,biological_process positive regulation of protein localization to synapse	NA	calsyntenin 3 [Source:HGNC Symbol%3BAcc:HGNC:18371]
ENSG00000182010	2.86	3.33	2.49	3.18	3.26	3.35	-0.178486749429061	2.61990582762157	0.279744083182489	0.663050877734098	10:62183034-62268707:-	RTKN2	2;GO:0007165,biological_process signal transduction;GO:0030097,biological_process hemopoiesis	NA	rhotekin 2 [Source:HGNC Symbol%3BAcc:HGNC:19364]
ENSG00000125863	27.85	27.89	28.59	30.11	27.83	31.54	-0.0741642343198148	5.89662796289673	0.279747211412791	0.663050877734098	20:10401008-10434222:-	MKKS	57;GO:0000166,molecular_function nucleotide binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001947,biological_process heart looping;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007286,biological_process spermatid development;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0007601,biological_process visual perception;GO:0007608,biological_process sensory perception of smell;GO:0008406,biological_process gonad development;GO:0010629,biological_process negative regulation of gene expression;GO:0014824,biological_process artery smooth muscle contraction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021756,biological_process striatum development;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0031514,cellular_component motile cilium;GO:0032402,biological_process melanosome transport;GO:0033210,biological_process leptin-mediated signaling pathway;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035176,biological_process social behavior;GO:0036064,cellular_component ciliary basal body;GO:0038108,biological_process negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042311,biological_process vasodilation;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044321,biological_process response to leptin;GO:0045444,biological_process fat cell differentiation;GO:0045494,biological_process photoreceptor cell maintenance;GO:0045776,biological_process negative regulation of blood pressure;GO:0046907,biological_process intracellular transport;GO:0048854,biological_process brain morphogenesis;GO:0050896,biological_process response to stimulus;GO:0050910,biological_process detection of mechanical stimulus involved in sensory perception of sound;GO:0051082,molecular_function unfolded protein binding;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051216,biological_process cartilage development;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051877,biological_process pigment granule aggregation in cell center;GO:0060027,biological_process convergent extension involved in gastrulation;GO:0060271,biological_process cilium morphogenesis;GO:0060296,biological_process regulation of cilium beat frequency involved in ciliary motility;GO:0060324,biological_process face development;GO:0061077,biological_process chaperone-mediated protein folding;GO:1902636,cellular_component kinociliary basal body;GO:1905515,biological_process non-motile cilium assembly	NA	McKusick-Kaufman syndrome [Source:HGNC Symbol%3BAcc:HGNC:7108]
ENSG00000143315	6.73	7.61	7.48	6.61	9.32	8.59	-0.160515875711619	3.3156669702982	0.279784096035937	0.663050877734098	1:160027672-160031991:-	PIGM	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups	PIGM; GPI mannosyltransferase 1 subunit M [EC:2.4.1.-]; K05284	phosphatidylinositol glycan anchor biosynthesis class M [Source:HGNC Symbol%3BAcc:HGNC:18858]
ENSG00000120948	41.01	42.61	38.83	43.07	44.64	41.99	-0.0732442236762547	5.98865630341462	0.27979297504708	0.663050877734098	1:11012343-11026420:+	TARDBP	30;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005726,cellular_component perichromatin fibrils;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010629,biological_process negative regulation of gene expression;GO:0016607,cellular_component nuclear speck;GO:0032024,biological_process positive regulation of insulin secretion;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035061,cellular_component interchromatin granule;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051726,biological_process regulation of cell cycle;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:0071765,biological_process nuclear inner membrane organization	NA	TAR DNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:11571]
ENSG00000184949	3.72	3.66	3.38	3.33	3.29	3.16	0.148414422119045	2.77483453076727	0.27984560931676	0.663050877734098	22:38578119-38656629:-	FAM227A	NA	NA	family with sequence similarity 227 member A [Source:HGNC Symbol%3BAcc:HGNC:44197]
ENSG00000151304	12.24	10.32	13.27	13.09	11.90	14.48	-0.12058053018563	4.03502154048556	0.279950354952296	0.663100437589812	5:121961960-122075570:+	SRFBP1	8;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030686,cellular_component 90S preribosome;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	serum response factor binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26333]
ENSG00000142230	83.37	88.13	80.11	90.48	88.85	86.94	-0.0713804082287777	6.83878470944799	0.280002930579963	0.663100437589812	19:47113273-47210636:+	SAE1	19;GO:0004839,molecular_function ubiquitin activating enzyme activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0008022,molecular_function protein C-terminus binding;GO:0008047,molecular_function enzyme activator activity;GO:0008641,molecular_function small protein activating enzyme activity;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019948,molecular_function SUMO activating enzyme activity;GO:0031510,cellular_component SUMO activating enzyme complex;GO:0043008,molecular_function ATP-dependent protein binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0044388,molecular_function small protein activating enzyme binding;GO:0046982,molecular_function protein heterodimerization activity;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	UBLE1A, SAE1; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]; K10684	SUMO1 activating enzyme subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:30660]
ENSG00000152952	244.94	228.16	244.52	231.93	221.04	238.29	0.0660525259839364	9.17962276444991	0.28002678593779	0.663100437589812	3:146069439-146163653:-	PLOD2	17;GO:0001666,biological_process response to hypoxia;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006464,biological_process cellular protein modification process;GO:0008475,molecular_function procollagen-lysine 5-dioxygenase activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0017185,biological_process peptidyl-lysine hydroxylation;GO:0030867,cellular_component rough endoplasmic reticulum membrane;GO:0031418,molecular_function L-ascorbic acid binding;GO:0046872,molecular_function metal ion binding;GO:0046947,biological_process hydroxylysine biosynthetic process;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]; K13645	procollagen-lysine%2C2-oxoglutarate 5-dioxygenase 2 [Source:HGNC Symbol%3BAcc:HGNC:9082]
ENSG00000160055	18.42	14.52	16.30	17.53	13.82	13.71	0.148245775602508	3.65597335728488	0.280215195080948	0.663247448531123	1:32214471-32222359:-	TMEM234	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 234 [Source:HGNC Symbol%3BAcc:HGNC:28837]
ENSG00000221963	42.90	39.47	43.35	45.04	41.50	47.77	-0.0812049941544507	5.48665137814474	0.280245820941171	0.663247448531123	22:35648394-35668409:+	APOL6	9;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042157,biological_process lipoprotein metabolic process	NA	apolipoprotein L6 [Source:HGNC Symbol%3BAcc:HGNC:14870]
ENSG00000144713	1250.03	1181.14	1244.64	1384.72	1219.43	1287.79	-0.0705693247925383	9.17862371293571	0.280285010646462	0.663247448531123	3:12834484-12841588:-	RPL32	16;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0097421,biological_process liver regeneration	NA	ribosomal protein L32 [Source:HGNC Symbol%3BAcc:HGNC:10336]
ENSG00000197008	8.94	8.27	8.38	8.93	8.84	10.63	-0.13824625080845	3.33198563549499	0.280302595262569	0.663247448531123	7:64794387-64833681:+	ZNF138	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 138 [Source:HGNC Symbol%3BAcc:HGNC:12922]
ENSG00000116977	41.05	42.77	41.21	38.86	40.21	40.61	0.072584653969272	5.46183634438815	0.280373328978632	0.663288380524445	1:236517999-236552981:+	LGALS8	13;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0030246,molecular_function carbohydrate binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0070062,cellular_component extracellular exosome;GO:0098586,biological_process cellular response to virus;GO:0098792,biological_process xenophagy;GO:1904977,biological_process lymphatic endothelial cell migration	NA	galectin 8 [Source:HGNC Symbol%3BAcc:HGNC:6569]
ENSG00000205981	79.96	70.58	82.27	78.10	91.10	82.44	-0.0942236803998557	4.82413870891969	0.280716635594951	0.66397400869667	3:180983708-180989774:-	DNAJC19	12;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006457,biological_process protein folding;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0007601,biological_process visual perception;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043234,cellular_component protein complex;GO:0048806,biological_process genitalia development	NA	DnaJ heat shock protein family (Hsp40) member C19 [Source:HGNC Symbol%3BAcc:HGNC:30528]
ENSG00000138794	34.27	37.57	32.95	37.86	37.75	36.36	-0.0888138722758413	4.99667352678223	0.280821356469863	0.664095160575427	4:109688621-109703583:-	CASP6	17;GO:0004175,molecular_function endopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030855,biological_process epithelial cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0072734,biological_process cellular response to staurosporine;GO:0097194,biological_process execution phase of apoptosis;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis	CASP6; caspase 6 [EC:3.4.22.59]; K04396	caspase 6 [Source:HGNC Symbol%3BAcc:HGNC:1507]
ENSG00000278023	2.30	1.97	2.96	2.28	2.89	3.75	-0.277051427128695	1.40992240568235	0.280875778846668	0.664097341490227	17:35918065-35930773:-	RDM1	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0015030,cellular_component Cajal body;GO:0016605,cellular_component PML body	NA	RAD52 motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19950]
ENSG00000100150	3.26	3.03	3.23	3.65	3.76	3.03	-0.116732254436324	4.02985637366718	0.280969059934061	0.664191380872501	22:31753950-31907034:+	DEPDC5	16;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032403,molecular_function protein complex binding;GO:0034198,biological_process cellular response to amino acid starvation;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:1904262,biological_process negative regulation of TORC1 signaling;GO:1990130,cellular_component Iml1 complex	NA	DEP domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:18423]
ENSG00000140830	21.25	17.91	21.09	20.91	20.09	26.23	-0.141057485205194	3.58681827628685	0.281157298080306	0.664429563801955	16:72044288-72094431:-	TXNL4B	12;GO:0000245,biological_process spliceosomal complex assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0008380,biological_process RNA splicing;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex	NA	thioredoxin like 4B [Source:HGNC Symbol%3BAcc:HGNC:26041]
ENSG00000197566	1.31	1.22	1.42	1.27	1.46	1.92	-0.226768462312261	1.9624935108896	0.281221709271352	0.664429563801955	17:16620736-16653856:-	ZNF624	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 624 [Source:HGNC Symbol%3BAcc:HGNC:29254]
ENSG00000164695	23.85	24.34	24.85	25.17	27.13	26.56	-0.0993925570559688	4.15922543154194	0.281230397826107	0.664429563801955	8:81732433-81759515:+	CHMP4C	30;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007080,biological_process mitotic metaphase plate congression;GO:0009838,biological_process abscission;GO:0010824,biological_process regulation of centrosome duplication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0030496,cellular_component midbody;GO:0031902,cellular_component late endosome membrane;GO:0032466,biological_process negative regulation of cytokinesis;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042803,molecular_function protein homodimerization activity;GO:0044878,biological_process mitotic cytokinesis checkpoint;GO:0050792,biological_process regulation of viral process;GO:0070062,cellular_component extracellular exosome;GO:0090543,cellular_component Flemming body;GO:0090611,biological_process ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1902188,biological_process positive regulation of viral release from host cell	CHMP4, SNF7, VPS32; charged multivesicular body protein 4; K12194	charged multivesicular body protein 4C [Source:HGNC Symbol%3BAcc:HGNC:30599]
ENSG00000177082	23.93	22.96	23.84	22.58	22.87	21.91	0.0850235717427478	4.80472164767583	0.281397279685415	0.664574457048483	15:84639280-84654343:-	WDR73	6;GO:0000922,cellular_component spindle pole;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0032154,cellular_component cleavage furrow	NA	WD repeat domain 73 [Source:HGNC Symbol%3BAcc:HGNC:25928]
ENSG00000153933	2.86	1.93	2.48	3.11	2.09	3.44	-0.224487525568165	2.30149234293838	0.281430270087666	0.664574457048483	17:56834098-56869567:+	DGKE	20;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030168,biological_process platelet activation;GO:0035556,biological_process intracellular signal transduction;GO:0046834,biological_process lipid phosphorylation;GO:0046872,molecular_function metal ion binding	dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]; K00901	diacylglycerol kinase epsilon [Source:HGNC Symbol%3BAcc:HGNC:2852]
ENSG00000117748	39.01	40.02	40.79	45.68	39.15	42.97	-0.0819597254760254	5.52106181306456	0.281455165655088	0.664574457048483	1:27891523-27914746:-	RPA2	47;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0019899,molecular_function enzyme binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019985,biological_process translesion synthesis;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034502,biological_process protein localization to chromosome;GO:0035861,cellular_component site of double-strand break;GO:0036297,biological_process interstrand cross-link repair;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0047485,molecular_function protein N-terminus binding;GO:0070987,biological_process error-free translesion synthesis;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2000001,biological_process regulation of DNA damage checkpoint	RFA2, RPA2; replication factor A2; K10739	replication protein A2 [Source:HGNC Symbol%3BAcc:HGNC:10290]
ENSG00000134780	2.82	3.33	2.75	2.61	2.77	2.72	0.137688645165075	3.16527920547466	0.281577835128127	0.664574457048483	11:61680432-61747001:+	DAGLA	18;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007216,biological_process G-protein coupled glutamate receptor signaling pathway;GO:0007405,biological_process neuroblast proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0022008,biological_process neurogenesis;GO:0042136,biological_process neurotransmitter biosynthetic process;GO:0043196,cellular_component varicosity;GO:0045211,cellular_component postsynaptic membrane;GO:0046340,biological_process diacylglycerol catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047372,molecular_function acylglycerol lipase activity;GO:0071926,biological_process endocannabinoid signaling pathway;GO:0098921,biological_process retrograde trans-synaptic signaling by endocannabinoid	DAGL; sn1-specific diacylglycerol lipase [EC:3.1.1.-]; K13806	diacylglycerol lipase alpha [Source:HGNC Symbol%3BAcc:HGNC:1165]
ENSG00000090863	99.40	92.82	96.09	101.52	100.43	101.66	-0.0624903099651712	8.49466004971408	0.281579075859793	0.664574457048483	16:74447426-74607144:-	GLG1	14;GO:0000139,cellular_component Golgi membrane;GO:0005102,molecular_function receptor binding;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0010955,biological_process negative regulation of protein processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017134,molecular_function fibroblast growth factor binding;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0050900,biological_process leukocyte migration;GO:0060349,biological_process bone morphogenesis;GO:0070062,cellular_component extracellular exosome	GLG1, ESL1; golgi apparatus protein 1; K06816	golgi glycoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:4316]
ENSG00000049541	32.20	31.90	31.69	34.42	29.45	39.72	-0.102255050485784	5.44359287968902	0.281663605952185	0.664574457048483	7:74231498-74254458:-	RFC2	24;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005663,cellular_component DNA replication factor C complex;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0019899,molecular_function enzyme binding;GO:0019985,biological_process translesion synthesis;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0070987,biological_process error-free translesion synthesis;GO:1900264,biological_process positive regulation of DNA-directed DNA polymerase activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RFC2_4; replication factor C subunit 2/4; K10755	replication factor C subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:9970]
ENSG00000100605	24.59	26.00	24.50	23.60	24.02	23.89	0.0790901154514748	4.99634172269051	0.281679492033694	0.664574457048483	14:92936913-93116320:-	ITPK1	27;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0016853,molecular_function isomerase activity;GO:0021915,biological_process neural tube development;GO:0032957,biological_process inositol trisphosphate metabolic process;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0047325,molecular_function inositol tetrakisphosphate 1-kinase activity;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0052725,molecular_function inositol-1,3,4-trisphosphate 6-kinase activity;GO:0052726,molecular_function inositol-1,3,4-trisphosphate 5-kinase activity;GO:0052825,molecular_function inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity;GO:0052830,molecular_function inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity;GO:0052831,molecular_function inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity;GO:0052835,molecular_function inositol-3,4,6-trisphosphate 1-kinase activity	ITPK1; inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2.7.1.134]; K00913	inositol-tetrakisphosphate 1-kinase [Source:HGNC Symbol%3BAcc:HGNC:6177]
ENSG00000169217	45.15	43.16	48.28	47.94	47.97	49.28	-0.07365979521963	5.59319358101994	0.281720034881907	0.664574457048483	16:30350765-30355361:-	CD2BP2	14;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005682,cellular_component U5 snRNP;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016607,cellular_component nuclear speck;GO:0043021,molecular_function ribonucleoprotein complex binding	NA	CD2 cytoplasmic tail binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1656]
ENSG00000173272	64.87	56.81	58.86	59.87	67.44	66.08	-0.0837935969396083	5.2667294737688	0.281961791977666	0.66496303780785	2:131464899-131492743:-	MZT2A	8;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008274,cellular_component gamma-tubulin ring complex	NA	mitotic spindle organizing protein 2A [Source:HGNC Symbol%3BAcc:HGNC:33187]
ENSG00000166401	4.11	4.35	4.35	5.18	4.22	5.22	-0.18365443968917	2.48131868191621	0.282091074601894	0.66496303780785	18:63969924-64019779:+	SERPINB8	10;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0070062,cellular_component extracellular exosome;GO:0090136,biological_process epithelial cell-cell adhesion	SERPINB; serpin B; K13963	serpin family B member 8 [Source:HGNC Symbol%3BAcc:HGNC:8952]
ENSG00000116918	21.80	21.45	19.00	18.40	20.68	19.10	0.107493011188582	4.17143911309333	0.28213422334091	0.66496303780785	1:231528652-231566524:+	TSNAX	16;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0030154,biological_process cell differentiation;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	translin associated factor X [Source:HGNC Symbol%3BAcc:HGNC:12380]
ENSG00000011198	16.76	15.78	14.15	14.89	14.66	14.05	0.111117830143311	4.01672105432913	0.282150656316313	0.66496303780785	3:43690112-43734371:+	ABHD5	19;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008233,molecular_function peptidase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0010891,biological_process negative regulation of sequestering of triglyceride;GO:0010898,biological_process positive regulation of triglyceride catabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0042171,molecular_function lysophosphatidic acid acyltransferase activity;GO:0050996,biological_process positive regulation of lipid catabolic process;GO:0051006,biological_process positive regulation of lipoprotein lipase activity	ABHD5, CGI-58; abhydrolase domain-containing protein 5 [EC:2.3.1.51]; K13699	abhydrolase domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:21396]
ENSG00000196337	1.43	1.93	1.49	2.57	1.38	2.56	-0.438427588393645	0.123417927558424	0.282156442479546	0.66496303780785	19:49054274-49058860:-	CGB7	6;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007292,biological_process female gamete generation	NA	chorionic gonadotropin beta subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:16451]
ENSG00000085465	1.70	2.02	1.48	1.80	2.13	2.14	-0.227602258936803	1.98771735342712	0.282317474900612	0.66496303780785	1:111414313-111427777:-	OVGP1	15;GO:0004568,molecular_function chitinase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006032,biological_process chitin catabolic process;GO:0007338,biological_process single fertilization;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0007565,biological_process female pregnancy;GO:0008061,molecular_function chitin binding;GO:0030133,cellular_component transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035805,cellular_component egg coat;GO:0098595,cellular_component perivitelline space;GO:2000360,biological_process negative regulation of binding of sperm to zona pellucida	NA	oviductal glycoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:8524]
ENSG00000186532	6.48	5.36	5.84	5.91	6.87	6.59	-0.112002083016809	3.96586686201903	0.282328479490332	0.66496303780785	17:1779484-1830634:-	SMYD4	4;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	SET and MYND domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:21067]
ENSG00000153157	1.24	0.78	0.69	1.26	0.78	1.38	-0.305855925046819	1.42332202447941	0.28233925786026	0.66496303780785	6:10886830-10979320:+	SYCP2L	5;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000800,cellular_component lateral element;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0060548,biological_process negative regulation of cell death	NA	synaptonemal complex protein 2 like [Source:HGNC Symbol%3BAcc:HGNC:21537]
ENSG00000132467	52.29	53.27	51.94	54.71	52.78	59.31	-0.072189807599508	6.28315275646968	0.282366887318551	0.66496303780785	4:70688478-70690551:+	UTP3	11;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0016569,biological_process covalent chromatin modification;GO:0032040,cellular_component small-subunit processome	NA	UTP3%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:24477]
ENSG00000006459	4.05	3.29	4.04	4.04	3.19	3.15	0.155268130218958	3.40860427813839	0.282443448437919	0.665017170990116	7:140084745-140177035:-	KDM7A	26;GO:0005506,molecular_function iron ion binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0030901,biological_process midbrain development;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0035064,molecular_function methylated histone binding;GO:0035574,biological_process histone H4-K20 demethylation;GO:0035575,molecular_function histone demethylase activity (H4-K20 specific);GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation;GO:0071557,biological_process histone H3-K27 demethylation;GO:0071558,molecular_function histone demethylase activity (H3-K27 specific)	NA	lysine demethylase 7A [Source:HGNC Symbol%3BAcc:HGNC:22224]
ENSG00000136717	99.90	108.14	102.09	105.53	113.68	108.64	-0.0692367125581324	7.60125579457483	0.282819224090051	0.665775654964879	2:127048026-127107355:-	BIN1	33;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0006997,biological_process nucleus organization;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0030018,cellular_component Z disc;GO:0030100,biological_process regulation of endocytosis;GO:0030154,biological_process cell differentiation;GO:0030315,cellular_component T-tubule;GO:0030424,cellular_component axon;GO:0031674,cellular_component I band;GO:0033268,cellular_component node of Ranvier;GO:0042692,biological_process muscle cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043194,cellular_component axon initial segment;GO:0045664,biological_process regulation of neuron differentiation;GO:0048156,molecular_function tau protein binding;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0051015,molecular_function actin filament binding;GO:0051647,biological_process nucleus localization;GO:0060987,cellular_component lipid tube;GO:0060988,biological_process lipid tube assembly;GO:0061024,biological_process membrane organization;GO:0070063,molecular_function RNA polymerase binding;GO:0071156,biological_process regulation of cell cycle arrest	NA	bridging integrator 1 [Source:HGNC Symbol%3BAcc:HGNC:1052]
ENSG00000133997	27.27	27.97	28.60	27.41	30.79	32.05	-0.09610870716957	4.5533888476741	0.282937380210198	0.66581805675055	14:70581256-70600690:-	MED6	21;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001128,molecular_function RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070847,cellular_component core mediator complex	NA	mediator complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:19970]
ENSG00000153317	43.85	39.05	43.44	45.50	43.35	45.03	-0.070272270155356	7.24578225343973	0.282944513764533	0.66581805675055	8:130052103-130443660:-	ASAP1	19;GO:0001786,molecular_function phosphatidylserine binding;GO:0002102,cellular_component podosome;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0031253,cellular_component cell projection membrane;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis;GO:0061000,biological_process negative regulation of dendritic spine development;GO:0071803,biological_process positive regulation of podosome assembly;GO:1903527,biological_process positive regulation of membrane tubulation	ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein; K12488	ArfGAP with SH3 domain%2C ankyrin repeat and PH domain 1 [Source:HGNC Symbol%3BAcc:HGNC:2720]
ENSG00000162623	22.27	25.21	21.03	23.42	27.04	23.98	-0.114791868204162	4.21991741206318	0.283112770381012	0.666087721519997	1:74733151-74766678:+	TYW3	4;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	tRNA-yW synthesizing protein 3 homolog [Source:HGNC Symbol%3BAcc:HGNC:24757]
ENSG00000197562	15.98	13.50	16.95	15.94	15.84	19.43	-0.123281593199028	4.01250266917629	0.283369133227642	0.666564534916566	16:589356-629272:+	RAB40C	14;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0019003,molecular_function GDP binding;GO:0030667,cellular_component secretory granule membrane;GO:0035556,biological_process intracellular signal transduction;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0072659,biological_process protein localization to plasma membrane	NA	RAB40C%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:18285]
ENSG00000146426	0.44	0.49	0.60	0.57	0.60	0.64	-0.229970590638028	1.63335444584709	0.283476938925536	0.666691785313126	6:154832696-155257723:+	TIAM2	20;GO:0005057,molecular_function receptor signaling protein activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0030426,cellular_component growth cone;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome	NA	T-cell lymphoma invasion and metastasis 2 [Source:HGNC Symbol%3BAcc:HGNC:11806]
ENSG00000164442	384.38	357.24	412.79	371.55	363.03	373.75	0.0711877428463066	8.28336766722971	0.283579247924207	0.666806062603368	6:139371806-139374620:-	CITED2	87;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001568,biological_process blood vessel development;GO:0001570,biological_process vasculogenesis;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001829,biological_process trophectodermal cell differentiation;GO:0001841,biological_process neural tube formation;GO:0001843,biological_process neural tube closure;GO:0001889,biological_process liver development;GO:0001892,biological_process embryonic placenta development;GO:0001944,biological_process vasculature development;GO:0001947,biological_process heart looping;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002521,biological_process leukocyte differentiation;GO:0003151,biological_process outflow tract morphogenesis;GO:0003156,biological_process regulation of organ formation;GO:0003197,biological_process endocardial cushion development;GO:0003281,biological_process ventricular septum development;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007417,biological_process central nervous system development;GO:0007422,biological_process peripheral nervous system development;GO:0007507,biological_process heart development;GO:0007530,biological_process sex determination;GO:0007569,biological_process cell aging;GO:0008283,biological_process cell proliferation;GO:0008584,biological_process male gonad development;GO:0009612,biological_process response to mechanical stimulus;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0019904,molecular_function protein domain specific binding;GO:0021602,biological_process cranial nerve morphogenesis;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030154,biological_process cell differentiation;GO:0030325,biological_process adrenal gland development;GO:0030336,biological_process negative regulation of cell migration;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030851,biological_process granulocyte differentiation;GO:0034405,biological_process response to fluid shear stress;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035360,biological_process positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0035802,biological_process adrenal cortex formation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043627,biological_process response to estrogen;GO:0045787,biological_process positive regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046697,biological_process decidualization;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0048821,biological_process erythrocyte development;GO:0050693,molecular_function LBD domain binding;GO:0060136,biological_process embryonic process involved in female pregnancy;GO:0060349,biological_process bone morphogenesis;GO:0060411,biological_process cardiac septum morphogenesis;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060971,biological_process embryonic heart tube left/right pattern formation;GO:0060972,biological_process left/right pattern formation;GO:0061156,biological_process pulmonary artery morphogenesis;GO:0061308,biological_process cardiac neural crest cell development involved in heart development;GO:0061371,biological_process determination of heart left/right asymmetry;GO:0061428,biological_process negative regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070986,biological_process left/right axis specification;GO:0071363,biological_process cellular response to growth factor stimulus;GO:1900164,biological_process nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:2000020,biological_process positive regulation of male gonad development	NA	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 [Source:HGNC Symbol%3BAcc:HGNC:1987]
ENSG00000159873	15.51	12.43	12.74	12.24	12.76	12.42	0.140286501361491	3.47089286762886	0.283723736959941	0.667019459637074	22:28772673-28789301:+	CCDC117	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 117 [Source:HGNC Symbol%3BAcc:HGNC:26599]
ENSG00000095777	0.68	0.75	0.65	0.86	0.73	0.84	-0.217124289168229	1.9593093411646	0.283800848174799	0.667074404164699	10:25934266-26212527:+	MYO3A	28;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007601,biological_process visual perception;GO:0007605,biological_process sensory perception of sound;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016459,cellular_component myosin complex;GO:0016740,molecular_function transferase activity;GO:0030175,cellular_component filopodium;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0031941,cellular_component filamentous actin;GO:0032426,cellular_component stereocilium tip;GO:0032433,cellular_component filopodium tip;GO:0043531,molecular_function ADP binding;GO:0046777,biological_process protein autophosphorylation;GO:0050896,biological_process response to stimulus;GO:0060002,molecular_function plus-end directed microfilament motor activity;GO:0090103,biological_process cochlea morphogenesis	MYO3, DFNB30; myosin III [EC:2.7.11.1]; K08834	myosin IIIA [Source:HGNC Symbol%3BAcc:HGNC:7601]
ENSG00000121895	1.66	0.86	1.49	1.43	0.85	0.79	0.435125362591251	0.281650153080203	0.283887838247867	0.667084640542151	4:38966743-39032922:-	TMEM156	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 156 [Source:HGNC Symbol%3BAcc:HGNC:26260]
ENSG00000031698	279.96	202.13	271.75	295.95	238.52	290.98	-0.118880319239887	8.72730895320532	0.283912684764697	0.667084640542151	1:109213917-109238169:+	SARS	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004828,molecular_function serine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006434,biological_process seryl-tRNA aminoacylation;GO:0008033,biological_process tRNA processing;GO:0016259,biological_process selenocysteine metabolic process;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016874,molecular_function ligase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0070062,cellular_component extracellular exosome;GO:0097056,biological_process selenocysteinyl-tRNA(Sec) biosynthetic process;GO:0098619,molecular_function selenocysteine-tRNA ligase activity;GO:1904046,biological_process negative regulation of vascular endothelial growth factor production	SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]; K01875	seryl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:10537]
ENSG00000148337	39.56	36.16	37.47	40.50	40.07	39.19	-0.0680875175896172	6.79940833741962	0.283991068621719	0.667142531188757	9:128166063-128204383:-	CIZ1	10;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0008270,molecular_function zinc ion binding;GO:0030332,molecular_function cyclin binding;GO:0032298,biological_process positive regulation of DNA-dependent DNA replication initiation;GO:0046872,molecular_function metal ion binding;GO:0051457,biological_process maintenance of protein location in nucleus	NA	CDKN1A interacting zinc finger protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16744]
ENSG00000071794	39.44	39.40	38.77	41.24	40.20	42.69	-0.0664482895532068	6.93883970545451	0.284059292617742	0.667176537230659	3:149030126-149086554:-	HLTF	33;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006301,biological_process postreplication repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0016887,molecular_function ATPase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	helicase like transcription factor [Source:HGNC Symbol%3BAcc:HGNC:11099]
ENSG00000198646	10.84	11.76	12.33	11.41	11.47	10.49	0.0774534862398891	6.17269359917976	0.284312687594957	0.667645363434772	20:34689096-34825649:-	NCOA6	31;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0009725,biological_process response to hormone;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0030099,biological_process myeloid cell differentiation;GO:0030331,molecular_function estrogen receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0035097,cellular_component histone methyltransferase complex;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046965,molecular_function retinoid X receptor binding;GO:0046966,molecular_function thyroid hormone receptor binding	NA	nuclear receptor coactivator 6 [Source:HGNC Symbol%3BAcc:HGNC:15936]
ENSG00000152076	4.93	6.04	4.92	4.60	5.11	4.66	0.144497150161024	3.09677553427828	0.284380941331452	0.66767933133106	2:130139286-130145134:-	CCDC74B	NA	NA	coiled-coil domain containing 74B [Source:HGNC Symbol%3BAcc:HGNC:25267]
ENSG00000168813	6.54	6.29	7.05	6.70	6.82	8.13	-0.109549664332367	4.32823594751311	0.284574556571829	0.667996207564444	19:32345593-32387667:+	ZNF507	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 507 [Source:HGNC Symbol%3BAcc:HGNC:23783]
ENSG00000203326	5.82	4.85	5.54	5.19	4.94	4.79	0.143291529659149	3.14758452170849	0.28481802271161	0.667996207564444	19:53365692-53392217:+	ZNF525	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 525 [Source:HGNC Symbol%3BAcc:HGNC:29423]
ENSG00000115271	51.54	50.06	50.73	51.52	55.44	54.75	-0.0735127647028627	5.46489970750554	0.284835307531045	0.667996207564444	2:162318839-162371595:+	GCA	16;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0016020,cellular_component membrane;GO:0035578,cellular_component azurophil granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome	NA	grancalcin [Source:HGNC Symbol%3BAcc:HGNC:15990]
ENSG00000166974	7.62	9.87	7.60	9.24	10.26	8.48	-0.158190969920702	3.29051379202628	0.284840397806359	0.667996207564444	18:34976927-35143470:+	MAPRE2	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0008017,molecular_function microtubule binding;GO:0008283,biological_process cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0035371,cellular_component microtubule plus-end;GO:0042802,molecular_function identical protein binding;GO:0051301,biological_process cell division	NA	microtubule associated protein RP/EB family member 2 [Source:HGNC Symbol%3BAcc:HGNC:6891]
ENSG00000188215	10.07	9.95	11.46	10.92	8.40	9.33	0.150973097955351	3.21699253446913	0.284911181641671	0.667996207564444	16:20854924-20900384:-	DCUN1D3	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0010225,biological_process response to UV-C;GO:0010332,biological_process response to gamma radiation;GO:0016020,cellular_component membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032182,molecular_function ubiquitin-like protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0097602,molecular_function cullin family protein binding;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	defective in cullin neddylation 1 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28734]
ENSG00000272897	4.69	2.18	3.36	4.19	3.93	4.96	-0.306501104129699	1.04403763398843	0.284984892267546	0.667996207564444	20:35632339-35674544:-	AL109827.1	4;GO:0003824,molecular_function catalytic activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0031071,molecular_function cysteine desulfurase activity;GO:0044571,biological_process [2Fe-2S] cluster assembly	iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]; K04487	NA
ENSG00000166352	22.58	22.63	16.87	21.12	22.99	24.50	-0.138216162194103	3.86723428405634	0.285080792290899	0.667996207564444	11:36594492-36659290:+	C11orf74	1;GO:0005929,cellular_component cilium	NA	chromosome 11 open reading frame 74 [Source:HGNC Symbol%3BAcc:HGNC:25142]
ENSG00000180626	5.86	5.88	5.59	6.31	6.55	5.98	-0.108281133471554	3.88345095723367	0.285158021867805	0.667996207564444	17:5179535-5191883:-	ZNF594	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 594 [Source:HGNC Symbol%3BAcc:HGNC:29392]
ENSG00000131446	32.27	32.57	31.81	29.39	33.29	29.50	0.080191361259946	5.39790576130666	0.285165097924857	0.667996207564444	5:180784781-180815652:-	MGAT1	15;GO:0000139,cellular_component Golgi membrane;GO:0001701,biological_process in utero embryonic development;GO:0003827,molecular_function alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006049,biological_process UDP-N-acetylglucosamine catabolic process;GO:0006486,biological_process protein glycosylation;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	MGAT1; alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.101]; K00726	mannosyl (alpha-1%2C3-)-glycoprotein beta-1%2C2-N-acetylglucosaminyltransferase [Source:HGNC Symbol%3BAcc:HGNC:7044]
ENSG00000075275	27.88	27.00	28.53	27.68	25.77	26.93	0.0653954810883785	7.95067052504696	0.285177855939862	0.667996207564444	22:46360833-46537170:-	CELSR1	36;GO:0001736,biological_process establishment of planar polarity;GO:0001764,biological_process neuron migration;GO:0001843,biological_process neural tube closure;GO:0001942,biological_process hair follicle development;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007266,biological_process Rho protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0007626,biological_process locomotory behavior;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0042060,biological_process wound healing;GO:0042249,biological_process establishment of planar polarity of embryonic epithelium;GO:0042472,biological_process inner ear morphogenesis;GO:0045176,biological_process apical protein localization;GO:0046983,molecular_function protein dimerization activity;GO:0048105,biological_process establishment of body hair planar orientation;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060488,biological_process orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis;GO:0060489,biological_process planar dichotomous subdivision of terminal units involved in lung branching morphogenesis;GO:0060490,biological_process lateral sprouting involved in lung morphogenesis;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:0090251,biological_process protein localization involved in establishment of planar polarity	NA	cadherin EGF LAG seven-pass G-type receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:1850]
ENSG00000149313	45.03	43.50	41.52	46.20	46.72	45.21	-0.0747329489970592	5.37924944954105	0.28518773984765	0.667996207564444	11:106075500-106098710:+	AASDHPPT	11;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006633,biological_process fatty acid biosynthetic process;GO:0008897,molecular_function holo-[acyl-carrier-protein] synthase activity;GO:0015939,biological_process pantothenate metabolic process;GO:0016740,molecular_function transferase activity;GO:0019878,biological_process lysine biosynthetic process via aminoadipic acid;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	LYS5, acpT; 4'-phosphopantetheinyl transferase [EC:2.7.8.-]; K06133	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:HGNC Symbol%3BAcc:HGNC:14235]
ENSG00000203668	3.75	3.45	3.27	3.91	4.28	3.47	-0.14001491715682	3.17878545554129	0.285248429347175	0.667996207564444	1:241628852-241640254:-	CHML	20;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005968,cellular_component Rab-protein geranylgeranyltransferase complex;GO:0006886,biological_process intracellular protein transport;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0018344,biological_process protein geranylgeranylation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043687,biological_process post-translational protein modification;GO:0050790,biological_process regulation of catalytic activity;GO:0055114,biological_process oxidation-reduction process;GO:0061024,biological_process membrane organization	NA	CHM like%2C Rab escort protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1941]
ENSG00000198053	85.46	89.23	79.25	87.74	92.81	88.45	-0.0725933507279702	7.05553858835765	0.285267973128317	0.667996207564444	20:1894166-1940592:+	SIRPA	10;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017124,molecular_function SH3 domain binding;GO:0043312,biological_process neutrophil degranulation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane	SIRPA_B1_G, CD172; signal-regulatory protein alpha/beta1/gamma; K06551	signal regulatory protein alpha [Source:HGNC Symbol%3BAcc:HGNC:9662]
ENSG00000104419	691.36	555.97	754.96	795.94	621.32	770.69	-0.116115999666404	10.0368119218424	0.285357076449918	0.667996207564444	8:133237170-133302022:-	NDRG1	29;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0008017,molecular_function microtubule binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010038,biological_process response to metal ion;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0032287,biological_process peripheral nervous system myelin maintenance;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0043015,molecular_function gamma-tubulin binding;GO:0043209,cellular_component myelin sheath;GO:0045296,molecular_function cadherin binding;GO:0045576,biological_process mast cell activation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055038,cellular_component recycling endosome membrane;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia;GO:0090232,biological_process positive regulation of spindle checkpoint	NA	N-myc downstream regulated 1 [Source:HGNC Symbol%3BAcc:HGNC:7679]
ENSG00000147010	24.02	21.57	24.82	26.32	22.55	26.51	-0.0842191140610621	5.8916574765157	0.285550771483123	0.667996207564444	X:19533974-19887601:-	SH3KBP1	26;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0007010,biological_process cytoskeleton organization;GO:0007267,biological_process cell-cell signaling;GO:0007411,biological_process axon guidance;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0017124,molecular_function SH3 domain binding;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0061024,biological_process membrane organization	SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1; K12470	SH3 domain containing kinase binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:13867]
ENSG00000128274	61.36	62.99	62.20	59.95	60.59	58.90	0.0671217589330484	6.01709634109867	0.285562350203232	0.667996207564444	22:42692120-42721298:-	A4GALT	16;GO:0000139,cellular_component Golgi membrane;GO:0001576,biological_process globoside biosynthetic process;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006629,biological_process lipid metabolic process;GO:0006688,biological_process glycosphingolipid biosynthetic process;GO:0007009,biological_process plasma membrane organization;GO:0008378,molecular_function galactosyltransferase activity;GO:0015643,molecular_function toxic substance binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030173,cellular_component integral component of Golgi membrane;GO:0050512,molecular_function lactosylceramide 4-alpha-galactosyltransferase activity;GO:0070062,cellular_component extracellular exosome	A4GALT; lactosylceramide 4-alpha-galactosyltransferase [EC:2.4.1.228]; K01988	alpha 1%2C4-galactosyltransferase (P blood group) [Source:HGNC Symbol%3BAcc:HGNC:18149]
ENSG00000114405	41.38	54.50	48.30	55.37	57.47	45.78	-0.132428210965213	4.28344147654235	0.28560008113833	0.667996207564444	3:62318972-62336213:+	C3orf14	NA	NA	chromosome 3 open reading frame 14 [Source:HGNC Symbol%3BAcc:HGNC:25024]
ENSG00000183726	204.53	215.28	189.71	200.45	194.03	188.71	0.0737364897849659	6.55108775636366	0.285608080808267	0.667996207564444	1:25337916-25362361:+	TMEM50A	4;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 50A [Source:HGNC Symbol%3BAcc:HGNC:30590]
ENSG00000213809	3.16	1.33	2.39	0.92	2.81	1.52	0.43456343943349	0.5666767889845	0.285626080392	0.667996207564444	12:10372352-10391874:-	KLRK1	29;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030101,biological_process natural killer cell activation;GO:0030154,biological_process cell differentiation;GO:0030246,molecular_function carbohydrate binding;GO:0031295,biological_process T cell costimulation;GO:0032394,molecular_function MHC class Ib receptor activity;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0034260,biological_process negative regulation of GTPase activity;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0042288,molecular_function MHC class I protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045087,biological_process innate immune response;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0050776,biological_process regulation of immune response;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:2000502,biological_process negative regulation of natural killer cell chemotaxis	KLRK1, CD314; killer cell lectin-like receptor subfamily K member 1; K06728	killer cell lectin like receptor K1 [Source:HGNC Symbol%3BAcc:HGNC:18788]
ENSG00000137819	2.57	1.83	3.34	2.87	2.98	3.55	-0.245742312857194	1.59612215736837	0.285663176336884	0.667996207564444	15:69298946-69407780:+	PAQR5	12;GO:0003707,molecular_function steroid hormone receptor activity;GO:0005496,molecular_function steroid binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0048477,biological_process oogenesis;GO:0048545,biological_process response to steroid hormone	NA	progestin and adipoQ receptor family member 5 [Source:HGNC Symbol%3BAcc:HGNC:29645]
ENSG00000116729	44.48	44.62	44.45	47.62	45.65	47.74	-0.0669224336481902	6.47114230794945	0.285663592387101	0.667996207564444	1:68098472-68233120:-	WLS	34;GO:0000139,cellular_component Golgi membrane;GO:0001707,biological_process mesoderm formation;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0007275,biological_process multicellular organism development;GO:0009948,biological_process anterior/posterior axis specification;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030901,biological_process midbrain development;GO:0030902,biological_process hindbrain development;GO:0031017,biological_process exocrine pancreas development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031852,molecular_function mu-type opioid receptor binding;GO:0031901,cellular_component early endosome membrane;GO:0032590,cellular_component dendrite membrane;GO:0032839,cellular_component dendrite cytoplasm;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0061355,biological_process Wnt protein secretion;GO:0061357,biological_process positive regulation of Wnt protein secretion;GO:0070062,cellular_component extracellular exosome;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	wntless Wnt ligand secretion mediator [Source:HGNC Symbol%3BAcc:HGNC:30238]
ENSG00000130202	44.51	42.95	40.52	38.31	43.11	41.09	0.0746808795595902	6.39338488894503	0.285699820024138	0.667996207564444	19:44846174-44889228:+	NECTIN2	48;GO:0001618,molecular_function virus receptor activity;GO:0001675,biological_process acrosome assembly;GO:0002860,biological_process positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0002891,biological_process positive regulation of immunoglobulin mediated immune response;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005915,cellular_component zonula adherens;GO:0005925,cellular_component focal adhesion;GO:0007010,biological_process cytoskeleton organization;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007286,biological_process spermatid development;GO:0007289,biological_process spermatid nucleus differentiation;GO:0008037,biological_process cell recognition;GO:0009566,biological_process fertilization;GO:0009986,cellular_component cell surface;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019064,biological_process fusion of virus membrane with host plasma membrane;GO:0030382,biological_process sperm mitochondrion organization;GO:0032990,biological_process cell part morphogenesis;GO:0033005,biological_process positive regulation of mast cell activation;GO:0034332,biological_process adherens junction organization;GO:0042271,biological_process susceptibility to natural killer cell mediated cytotoxicity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043296,cellular_component apical junction complex;GO:0044291,cellular_component cell-cell contact zone;GO:0044406,biological_process adhesion of symbiont to host;GO:0044782,biological_process cilium organization;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0046596,biological_process regulation of viral entry into host cell;GO:0046718,biological_process viral entry into host cell;GO:0046814,biological_process coreceptor-mediated virion attachment to host cell;GO:0046982,molecular_function protein heterodimerization activity;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051654,biological_process establishment of mitochondrion localization;GO:0060370,biological_process susceptibility to T cell mediated cytotoxicity;GO:0070062,cellular_component extracellular exosome	PVRL2, CD112; poliovirus receptor-related protein 2; K06531	nectin cell adhesion molecule 2 [Source:HGNC Symbol%3BAcc:HGNC:9707]
ENSG00000049656	71.06	75.49	65.30	67.73	70.53	64.04	0.0769079006425957	6.80157411220077	0.285760719820293	0.66801277121079	5:1317743-1345099:-	CLPTM1L	3;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CLPTM1 like [Source:HGNC Symbol%3BAcc:HGNC:24308]
ENSG00000170873	34.31	29.52	34.96	33.07	28.60	32.29	0.0867119481771055	6.37981904755176	0.285916002491642	0.668249922600028	8:124550789-124728429:-	MTSS1	22;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006928,biological_process movement of cell or subcellular component;GO:0007009,biological_process plasma membrane organization;GO:0007155,biological_process cell adhesion;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0015629,cellular_component actin cytoskeleton;GO:0030035,biological_process microspike assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030139,cellular_component endocytic vesicle;GO:0042802,molecular_function identical protein binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0061333,biological_process renal tubule morphogenesis;GO:0071498,biological_process cellular response to fluid shear stress;GO:0072102,biological_process glomerulus morphogenesis;GO:0072160,biological_process nephron tubule epithelial cell differentiation;GO:2001013,biological_process epithelial cell proliferation involved in renal tubule morphogenesis	NA	MTSS1%2C I-BAR domain containing [Source:HGNC Symbol%3BAcc:HGNC:20443]
ENSG00000188811	18.25	21.85	18.24	16.97	17.63	19.66	0.106304907211576	4.29500277508274	0.286062432365098	0.668466297618215	13:39038305-39050109:+	NHLRC3	4;GO:0005576,cellular_component extracellular region;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	NHL repeat containing 3 [Source:HGNC Symbol%3BAcc:HGNC:33751]
ENSG00000053501	22.34	21.78	22.00	17.16	20.87	23.29	0.119275863820833	4.1061727942239	0.286221764879816	0.668712736204246	19:17215345-17219829:+	USE1	12;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007041,biological_process lysosomal transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030163,biological_process protein catabolic process;GO:0032940,biological_process secretion by cell	USE1; unconventional SNARE in the endoplasmic reticulum protein 1; K08507	unconventional SNARE in the ER 1 [Source:HGNC Symbol%3BAcc:HGNC:30882]
ENSG00000006534	37.76	38.84	39.40	42.86	40.55	39.40	-0.0707136690843076	5.96067652117365	0.28635129163116	0.668825547690124	11:68008577-68029282:+	ALDH3B1	23;GO:0004028,molecular_function 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0004030,molecular_function aldehyde dehydrogenase [NAD(P)+] activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006066,biological_process alcohol metabolic process;GO:0006068,biological_process ethanol catabolic process;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030667,cellular_component secretory granule membrane;GO:0031982,cellular_component vesicle;GO:0034599,biological_process cellular response to oxidative stress;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0046185,biological_process aldehyde catabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]; K00129	aldehyde dehydrogenase 3 family member B1 [Source:HGNC Symbol%3BAcc:HGNC:410]
ENSG00000185278	1.17	1.16	0.80	1.34	1.40	1.12	-0.296586960429622	0.982785659354745	0.286378364467465	0.668825547690124	1:173868081-173903549:+	ZBTB37	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 37 [Source:HGNC Symbol%3BAcc:HGNC:28365]
ENSG00000165660	11.35	8.98	12.71	10.04	9.87	10.51	0.142041408050843	3.74278537918903	0.286440573715759	0.668825547690124	10:124801784-124836670:+	ABRAXAS2	23;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0002931,biological_process response to ischemia;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0008017,molecular_function microtubule binding;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0016579,biological_process protein deubiquitination;GO:0030496,cellular_component midbody;GO:0031593,molecular_function polyubiquitin binding;GO:0031616,cellular_component spindle pole centrosome;GO:0036449,cellular_component microtubule minus-end;GO:0051301,biological_process cell division;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070552,cellular_component BRISC complex;GO:0090307,biological_process mitotic spindle assembly	NA	abraxas 2%2C BRISC complex subunit [Source:HGNC Symbol%3BAcc:HGNC:28975]
ENSG00000104979	190.59	191.40	184.73	197.62	194.63	206.40	-0.0683519962603598	6.11171166829767	0.286563163793871	0.668825547690124	19:13774167-13778462:+	C19orf53	2;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus	NA	chromosome 19 open reading frame 53 [Source:HGNC Symbol%3BAcc:HGNC:24991]
ENSG00000160336	10.36	11.71	10.86	10.96	12.25	12.15	-0.0957711285529013	4.72423535036494	0.286702414262724	0.668825547690124	19:53431992-53458261:+	ZNF761	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 761 [Source:HGNC Symbol%3BAcc:HGNC:23179]
ENSG00000103174	7.93	8.48	7.07	6.87	8.24	6.41	0.13353149527446	3.64713115020715	0.286730876317615	0.668825547690124	16:5024843-5034141:-	NAGPA	14;GO:0003944,molecular_function N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0006622,biological_process protein targeting to lysosome;GO:0007040,biological_process lysosome organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033299,biological_process secretion of lysosomal enzymes	NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [EC:3.1.4.45]; K01125	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Source:HGNC Symbol%3BAcc:HGNC:17378]
ENSG00000139579	29.23	35.48	37.67	36.55	37.50	36.99	-0.109106713908728	4.50240534152482	0.286771098847534	0.668825547690124	12:56222014-56229854:+	NABP2	19;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0010212,biological_process response to ionizing radiation;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0070182,molecular_function DNA polymerase binding;GO:0070200,biological_process establishment of protein localization to telomere;GO:0070876,cellular_component SOSS complex;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1904355,biological_process positive regulation of telomere capping	NA	nucleic acid binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:28412]
ENSG00000162814	4.30	3.09	3.33	4.22	3.99	4.29	-0.193183103670786	2.13011958214308	0.28679448698984	0.668825547690124	1:217631323-217871696:+	SPATA17	2;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm	NA	spermatogenesis associated 17 [Source:HGNC Symbol%3BAcc:HGNC:25184]
ENSG00000104691	3.96	3.82	3.73	3.57	3.84	2.93	0.168828754393595	2.64368464737801	0.286806146767849	0.668825547690124	8:30732246-30767006:+	UBXN8	12;GO:0003676,molecular_function nucleic acid binding;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007338,biological_process single fertilization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	UBX domain protein 8 [Source:HGNC Symbol%3BAcc:HGNC:30307]
ENSG00000132639	16.60	13.63	18.00	15.56	14.53	14.33	0.142247017059704	3.53155185114642	0.2868287092925	0.668825547690124	20:10218829-10307418:+	SNAP25	47;GO:0000149,molecular_function SNARE binding;GO:0001504,biological_process neurotransmitter uptake;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0007626,biological_process locomotory behavior;GO:0008021,cellular_component synaptic vesicle;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0008306,biological_process associative learning;GO:0010975,biological_process regulation of neuron projection development;GO:0014047,biological_process glutamate secretion;GO:0016020,cellular_component membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016081,biological_process synaptic vesicle docking;GO:0016082,biological_process synaptic vesicle priming;GO:0017075,molecular_function syntaxin-1 binding;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031083,cellular_component BLOC-1 complex;GO:0031201,cellular_component SNARE complex;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0031915,biological_process positive regulation of synaptic plasticity;GO:0031982,cellular_component vesicle;GO:0035579,cellular_component specific granule membrane;GO:0036477,cellular_component somatodendritic compartment;GO:0042734,cellular_component presynaptic membrane;GO:0043005,cellular_component neuron projection;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0045202,cellular_component synapse;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050796,biological_process regulation of insulin secretion;GO:0060291,biological_process long-term synaptic potentiation;GO:0070032,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0070201,biological_process regulation of establishment of protein localization;GO:0070821,cellular_component tertiary granule membrane;GO:0098794,cellular_component postsynapse;GO:0098967,biological_process exocytic insertion of neurotransmitter receptor to postsynaptic membrane;GO:0099590,biological_process neurotransmitter receptor internalization;GO:1990926,biological_process short-term synaptic potentiation	SNAP23; synaptosomal-associated protein 23; K08508	synaptosome associated protein 25 [Source:HGNC Symbol%3BAcc:HGNC:11132]
ENSG00000115317	21.98	24.16	23.38	25.70	21.28	28.30	-0.106484785995168	5.09023326780886	0.286893429201118	0.668825547690124	2:74529376-74533348:+	HTRA2	57;GO:0000785,cellular_component chromatin;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0006672,biological_process ceramide metabolic process;GO:0006915,biological_process apoptotic process;GO:0007005,biological_process mitochondrion organization;GO:0007568,biological_process aging;GO:0007628,biological_process adult walking behavior;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008344,biological_process adult locomotory behavior;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009635,biological_process response to herbicide;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010822,biological_process positive regulation of mitochondrion organization;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016540,biological_process protein autoprocessing;GO:0016787,molecular_function hydrolase activity;GO:0019742,biological_process pentacyclic triterpenoid metabolic process;GO:0030900,biological_process forebrain development;GO:0031966,cellular_component mitochondrial membrane;GO:0034599,biological_process cellular response to oxidative stress;GO:0034605,biological_process cellular response to heat;GO:0035458,biological_process cellular response to interferon-beta;GO:0035631,cellular_component CD40 receptor complex;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044257,biological_process cellular protein catabolic process;GO:0045786,biological_process negative regulation of cell cycle;GO:0048666,biological_process neuron development;GO:0051082,molecular_function unfolded protein binding;GO:0060548,biological_process negative regulation of cell death;GO:0070207,biological_process protein homotrimerization;GO:0071300,biological_process cellular response to retinoic acid;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:0097194,biological_process execution phase of apoptosis;GO:1901215,biological_process negative regulation of neuron death;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1904924,biological_process negative regulation of mitophagy in response to mitochondrial depolarization;GO:1905370,cellular_component serine-type endopeptidase complex;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001269,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	HTRA2, PRSS25; HtrA serine peptidase 2 [EC:3.4.21.108]; K08669	HtrA serine peptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:14348]
ENSG00000128849	12.51	14.88	12.57	11.56	13.96	12.12	0.0943448988615131	5.6603608292528	0.286999749561853	0.668825547690124	15:57375966-57550727:+	CGNL1	4;GO:0003774,molecular_function motor activity;GO:0005923,cellular_component bicellular tight junction;GO:0016459,cellular_component myosin complex;GO:0030054,cellular_component cell junction	NA	cingulin like 1 [Source:HGNC Symbol%3BAcc:HGNC:25931]
ENSG00000125485	9.18	9.09	9.49	9.94	7.62	8.39	0.109961001830585	4.55433701363128	0.2872033521886	0.668825547690124	9:132592996-132670401:-	DDX31	15;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016787,molecular_function hydrolase activity;GO:0042254,biological_process ribosome biogenesis;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	DEAD-box helicase 31 [Source:HGNC Symbol%3BAcc:HGNC:16715]
ENSG00000187987	3.03	2.37	2.02	2.69	1.95	1.57	0.277231303820875	1.48544895806648	0.287215337295305	0.668825547690124	6:28431929-28443502:-	ZSCAN23	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	zinc finger and SCAN domain containing 23 [Source:HGNC Symbol%3BAcc:HGNC:21193]
ENSG00000089737	56.08	56.86	59.31	56.89	54.19	54.79	0.0663602405022913	7.21228441721629	0.287231163007008	0.668825547690124	14:94048290-94081245:-	DDX24	13;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0016787,molecular_function hydrolase activity	NA	DEAD-box helicase 24 [Source:HGNC Symbol%3BAcc:HGNC:13266]
ENSG00000108961	21.29	20.38	19.91	19.79	16.53	20.65	0.122688469782084	3.69421489209641	0.287233289379741	0.668825547690124	17:8288496-8290092:+	RANGRF	29;GO:0002027,biological_process regulation of heart rate;GO:0003254,biological_process regulation of membrane depolarization;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005087,molecular_function Ran guanyl-nucleotide exchange factor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0014704,cellular_component intercalated disc;GO:0015031,biological_process protein transport;GO:0017080,molecular_function sodium channel regulator activity;GO:0032527,biological_process protein exit from endoplasmic reticulum;GO:0042391,biological_process regulation of membrane potential;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044325,molecular_function ion channel binding;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0098905,biological_process regulation of bundle of His cell action potential;GO:0098909,biological_process regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:1900825,biological_process regulation of membrane depolarization during cardiac muscle cell action potential;GO:1902305,biological_process regulation of sodium ion transmembrane transport;GO:2000010,biological_process positive regulation of protein localization to cell surface;GO:2000649,biological_process regulation of sodium ion transmembrane transporter activity	NA	RAN guanine nucleotide release factor [Source:HGNC Symbol%3BAcc:HGNC:17679]
ENSG00000167657	32.86	36.30	34.70	32.91	35.34	30.62	0.080989821485993	5.60799670138881	0.287272723368504	0.668825547690124	19:3958452-3971123:-	DAPK3	48;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005884,cellular_component actin filament;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006940,biological_process regulation of smooth muscle contraction;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0008140,molecular_function cAMP response element binding protein binding;GO:0008360,biological_process regulation of cell shape;GO:0010506,biological_process regulation of autophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016569,biological_process covalent chromatin modification;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0017148,biological_process negative regulation of translation;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030182,biological_process neuron differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043519,biological_process regulation of myosin II filament organization;GO:0043522,molecular_function leucine zipper domain binding;GO:0045121,cellular_component membrane raft;GO:0046777,biological_process protein autophosphorylation;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0071346,biological_process cellular response to interferon-gamma;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097190,biological_process apoptotic signaling pathway;GO:2000145,biological_process regulation of cell motility;GO:2000249,biological_process regulation of actin cytoskeleton reorganization;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	DAPK; death-associated protein kinase [EC:2.7.11.1]; K08803	death associated protein kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:2676]
ENSG00000154359	6.54	5.87	7.09	6.22	5.92	6.10	0.115813347235434	3.93915136667831	0.287273667589	0.668825547690124	8:12721893-12756073:-	LONRF1	9;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	LON peptidase N-terminal domain and ring finger 1 [Source:HGNC Symbol%3BAcc:HGNC:26302]
ENSG00000086827	11.27	11.70	9.48	12.53	11.85	10.77	-0.106830302406704	4.72569156145285	0.287352723033423	0.668825547690124	11:113733186-113773811:-	ZW10	37;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005819,cellular_component spindle;GO:0005828,cellular_component kinetochore microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0007096,biological_process regulation of exit from mitosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019237,molecular_function centromeric DNA binding;GO:0034501,biological_process protein localization to kinetochore;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0070939,cellular_component Dsl1p complex;GO:1990423,cellular_component RZZ complex	NA	zw10 kinetochore protein [Source:HGNC Symbol%3BAcc:HGNC:13194]
ENSG00000156096	1.54	2.03	1.24	0.98	1.47	1.49	0.272704610614556	1.29860496809846	0.287429447100003	0.668825547690124	4:69480164-69526014:-	UGT2B4	14;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006711,biological_process estrogen catabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0052695,biological_process cellular glucuronidation	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 2 member B4 [Source:HGNC Symbol%3BAcc:HGNC:12553]
ENSG00000168237	1.78	1.63	1.21	1.45	2.00	2.10	-0.259740862232678	1.60953894533419	0.287439462031123	0.668825547690124	3:52287088-52293476:+	GLYCTK	13;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0008887,molecular_function glycerate kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0061624,biological_process fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	NA	glycerate kinase [Source:HGNC Symbol%3BAcc:HGNC:24247]
ENSG00000172361	2.34	1.80	2.24	2.82	2.41	2.28	-0.204729607336575	1.90550721021704	0.287481680003174	0.668825547690124	18:50227192-50266522:-	CFAP53	9;GO:0003341,biological_process cilium movement;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005929,cellular_component cilium;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry	NA	cilia and flagella associated protein 53 [Source:HGNC Symbol%3BAcc:HGNC:26530]
ENSG00000145741	361.13	362.93	364.55	398.71	351.85	402.68	-0.0715232751853919	7.85312275622085	0.28750931462777	0.668825547690124	5:73498407-73505635:+	BTF3	11;GO:0001701,biological_process in utero embryonic development;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport	EGD1, BTF3; nascent polypeptide-associated complex subunit beta; K01527	basic transcription factor 3 [Source:HGNC Symbol%3BAcc:HGNC:1125]
ENSG00000133935	83.91	107.17	85.34	77.37	96.97	82.71	0.1114729641595	5.22386280954674	0.287602942431218	0.668917992205117	14:75649790-75661189:-	ERG28	13;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006696,biological_process ergosterol biosynthetic process;GO:0008150,biological_process biological_process;GO:0008202,biological_process steroid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0030133,cellular_component transport vesicle;GO:0030674,molecular_function protein binding, bridging	NA	ergosterol biosynthesis 28 homolog [Source:HGNC Symbol%3BAcc:HGNC:1187]
ENSG00000179715	14.93	11.43	15.22	12.88	11.12	14.32	0.136889103327666	4.12965053737504	0.287688086368295	0.668942025509092	12:47079602-47236662:+	PCED1B	1;GO:0005515,molecular_function protein binding	NA	PC-esterase domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:28255]
ENSG00000163945	11.79	9.60	11.25	12.46	10.89	11.80	-0.088873856138366	5.33668792676132	0.287734257865533	0.668942025509092	4:1347265-1395992:+	UVSSA	18;GO:0000993,molecular_function RNA polymerase II core binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0043627,biological_process response to estrogen;GO:0051493,biological_process regulation of cytoskeleton organization	NA	UV stimulated scaffold protein A [Source:HGNC Symbol%3BAcc:HGNC:29304]
ENSG00000175376	25.25	28.96	25.87	25.11	25.59	23.44	0.116053913720076	3.68162351496853	0.287774946928104	0.668942025509092	11:65996544-66002176:-	EIF1AD	6;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation	NA	eukaryotic translation initiation factor 1A domain containing [Source:HGNC Symbol%3BAcc:HGNC:28147]
ENSG00000167536	16.55	14.62	15.62	14.63	15.56	13.80	0.107593759814941	4.11152867112972	0.287873202400174	0.669027975095027	17:28897780-28903071:-	DHRS13	4;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	dehydrogenase/reductase 13 [Source:HGNC Symbol%3BAcc:HGNC:28326]
ENSG00000186566	17.42	16.11	18.40	18.58	17.40	19.20	-0.0741254445868424	6.3434178629563	0.287919716664596	0.669027975095027	17:44395283-44503430:-	GPATCH8	6;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	G-patch domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:29066]
ENSG00000112851	21.96	22.41	19.51	19.68	21.21	20.15	0.0761727334991783	6.51434898211295	0.288026118117143	0.669149953993654	5:65926474-66082549:+	ERBIN	33;GO:0005102,molecular_function receptor binding;GO:0005176,molecular_function ErbB-2 class receptor binding;GO:0005178,molecular_function integrin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005604,cellular_component basement membrane;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006605,biological_process protein targeting;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0009925,cellular_component basal plasma membrane;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016323,cellular_component basolateral plasma membrane;GO:0016607,cellular_component nuclear speck;GO:0030054,cellular_component cell junction;GO:0030056,cellular_component hemidesmosome;GO:0031965,cellular_component nuclear membrane;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032495,biological_process response to muramyl dipeptide;GO:0032496,biological_process response to lipopolysaccharide;GO:0038128,biological_process ERBB2 signaling pathway;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0045175,biological_process basal protein localization;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0070433,biological_process negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071638,biological_process negative regulation of monocyte chemotactic protein-1 production	ERBB2IP, ERBIN; erbb2-interacting protein; K12796	erbb2 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:15842]
ENSG00000155366	160.58	171.45	163.63	176.79	175.81	170.64	-0.0673679722078937	7.10782728961437	0.28812446777388	0.669193570699763	1:112701105-112707434:-	RHOC	22;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0032154,cellular_component cleavage furrow;GO:0032420,cellular_component stereocilium;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043297,biological_process apical junction assembly;GO:0044319,biological_process wound healing, spreading of cells;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0060193,biological_process positive regulation of lipase activity;GO:0070062,cellular_component extracellular exosome;GO:1902766,biological_process skeletal muscle satellite cell migration	NA	ras homolog family member C [Source:HGNC Symbol%3BAcc:HGNC:669]
ENSG00000095261	28.30	24.76	24.49	27.43	28.03	27.32	-0.0793352054770661	5.40285989454733	0.288152713718701	0.669193570699763	9:120815495-120842984:-	PSMD5	32;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043248,biological_process proteasome assembly;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070682,biological_process proteasome regulatory particle assembly;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	NA	proteasome 26S subunit%2C non-ATPase 5 [Source:HGNC Symbol%3BAcc:HGNC:9563]
ENSG00000014914	17.40	14.21	18.17	17.24	12.01	16.61	0.133183891309311	5.11612781755997	0.288271302488497	0.669343748183635	1:149928650-149936869:-	MTMR11	1;GO:0070062,cellular_component extracellular exosome	NA	myotubularin related protein 11 [Source:HGNC Symbol%3BAcc:HGNC:24307]
ENSG00000174844	0.10	0.07	0.09	0.11	0.12	0.10	-0.354432735611464	0.43812631894395	0.288417122782836	0.669461516614105	3:57293698-57544344:-	DNAH12	12;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0016887,molecular_function ATPase activity;GO:0030286,cellular_component dynein complex;GO:0042995,cellular_component cell projection	NA	dynein axonemal heavy chain 12 [Source:HGNC Symbol%3BAcc:HGNC:2943]
ENSG00000153250	22.22	21.00	24.24	24.84	24.67	22.98	-0.0867629220020369	4.85651867933745	0.288607351383161	0.669461516614105	2:160272150-160493794:-	RBMS1	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0006396,biological_process RNA processing	NA	RNA binding motif single stranded interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9907]
ENSG00000124570	138.34	135.58	131.51	147.16	138.33	142.24	-0.0655605914852786	7.36712292693157	0.288640111402734	0.669461516614105	6:2948158-2972165:-	SERPINB6	17;GO:0002020,molecular_function protease binding;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007605,biological_process sensory perception of sound;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030667,cellular_component secretory granule membrane;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0071470,biological_process cellular response to osmotic stress;GO:0101003,cellular_component ficolin-1-rich granule membrane	SERPINB; serpin B; K13963	serpin family B member 6 [Source:HGNC Symbol%3BAcc:HGNC:8950]
ENSG00000148730	34.33	36.10	30.26	30.36	33.71	28.52	0.128650300204452	3.54984731644435	0.288672446682105	0.669461516614105	10:70404378-70428618:+	EIF4EBP2	18;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0007613,biological_process memory;GO:0008190,molecular_function eukaryotic initiation factor 4E binding;GO:0008286,biological_process insulin receptor signaling pathway;GO:0017148,biological_process negative regulation of translation;GO:0019933,biological_process cAMP-mediated signaling;GO:0030371,molecular_function translation repressor activity;GO:0031929,biological_process TOR signaling;GO:0035176,biological_process social behavior;GO:0045947,biological_process negative regulation of translational initiation;GO:0048167,biological_process regulation of synaptic plasticity;GO:0050804,biological_process modulation of synaptic transmission	NA	eukaryotic translation initiation factor 4E binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:3289]
ENSG00000120738	6.16	7.10	5.74	5.75	6.15	5.44	0.134767353628564	3.3167348450879	0.288684620779038	0.669461516614105	5:138465489-138469315:+	EGR1	52;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001666,biological_process response to hypoxia;GO:0002931,biological_process response to ischemia;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0009749,biological_process response to glucose;GO:0010385,molecular_function double-stranded methylated DNA binding;GO:0030217,biological_process T cell differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0032868,biological_process response to insulin;GO:0033233,biological_process regulation of protein sumoylation;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0042981,biological_process regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044729,molecular_function hemi-methylated DNA-binding;GO:0044849,biological_process estrous cycle;GO:0045080,biological_process positive regulation of chemokine biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046886,biological_process positive regulation of hormone biosynthetic process;GO:0050725,biological_process positive regulation of interleukin-1 beta biosynthetic process;GO:0060337,biological_process type I interferon signaling pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0071310,biological_process cellular response to organic substance;GO:0071480,biological_process cellular response to gamma radiation;GO:0071504,biological_process cellular response to heparin;GO:0071506,biological_process cellular response to mycophenolic acid;GO:0072110,biological_process glomerular mesangial cell proliferation;GO:0072303,biological_process positive regulation of glomerular metanephric mesangial cell proliferation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0098759,biological_process cellular response to interleukin-8;GO:1901216,biological_process positive regulation of neuron death;GO:1902949,biological_process positive regulation of tau-protein kinase activity;GO:1990841,molecular_function promoter-specific chromatin binding;GO:2000182,biological_process regulation of progesterone biosynthetic process	EGR1; early growth response protein 1; K09203	early growth response 1 [Source:HGNC Symbol%3BAcc:HGNC:3238]
ENSG00000118257	35.26	30.66	33.93	34.09	26.02	33.81	0.101107800076951	6.6474049729947	0.288685762222237	0.669461516614105	2:205681989-205798133:+	NRP2	44;GO:0001525,biological_process angiogenesis;GO:0001755,biological_process neural crest cell migration;GO:0001764,biological_process neuron migration;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002116,cellular_component semaphorin receptor complex;GO:0004872,molecular_function receptor activity;GO:0005021,molecular_function vascular endothelial growth factor-activated receptor activity;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007507,biological_process heart development;GO:0008201,molecular_function heparin binding;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0019838,molecular_function growth factor binding;GO:0019955,molecular_function cytokine binding;GO:0021612,biological_process facial nerve structural organization;GO:0021649,biological_process vestibulocochlear nerve structural organization;GO:0021675,biological_process nerve development;GO:0021828,biological_process gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0036486,biological_process ventral trunk neural crest cell migration;GO:0038084,biological_process vascular endothelial growth factor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048846,biological_process axon extension involved in axon guidance;GO:0050919,biological_process negative chemotaxis;GO:0061549,biological_process sympathetic ganglion development;GO:0061551,biological_process trigeminal ganglion development;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0097374,biological_process sensory neuron axon guidance;GO:0097490,biological_process sympathetic neuron projection extension;GO:0097491,biological_process sympathetic neuron projection guidance;GO:1901166,biological_process neural crest cell migration involved in autonomic nervous system development;GO:1902285,biological_process semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1903375,biological_process facioacoustic ganglion development;GO:1904835,biological_process dorsal root ganglion morphogenesis;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	neuropilin 2 [Source:HGNC Symbol%3BAcc:HGNC:8005]
ENSG00000253368	26.03	24.56	28.64	26.39	28.07	31.80	-0.107694926550317	4.24787202027451	0.28870067058684	0.669461516614105	1:26993706-27000898:+	TRNP1	12;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005719,cellular_component nuclear euchromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0021696,biological_process cerebellar cortex morphogenesis;GO:0042127,biological_process regulation of cell proliferation;GO:0051726,biological_process regulation of cell cycle;GO:0061351,biological_process neural precursor cell proliferation	NA	TMF1-regulated nuclear protein 1 [Source:HGNC Symbol%3BAcc:HGNC:34348]
ENSG00000221909	12.16	10.34	11.47	10.15	10.54	11.29	0.105216865906928	4.25550794341143	0.288766101454463	0.669461516614105	7:99546307-99558536:-	FAM200A	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 200 member A [Source:HGNC Symbol%3BAcc:HGNC:25401]
ENSG00000130175	286.98	292.92	294.86	278.66	290.12	276.34	0.0614694065649127	9.01016407277744	0.288857159557124	0.669461516614105	19:11435287-11450968:+	PRKCSH	20;GO:0001701,biological_process in utero embryonic development;GO:0001889,biological_process liver development;GO:0003723,molecular_function RNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005509,molecular_function calcium ion binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006457,biological_process protein folding;GO:0006491,biological_process N-glycan processing;GO:0006807,biological_process nitrogen compound metabolic process;GO:0010977,biological_process negative regulation of neuron projection development;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0044325,molecular_function ion channel binding;GO:0046872,molecular_function metal ion binding;GO:0051219,molecular_function phosphoprotein binding;GO:0051291,biological_process protein heterooligomerization;GO:0072001,biological_process renal system development	PRKCSH; protein kinase C substrate 80K-H; K08288	protein kinase C substrate 80K-H [Source:HGNC Symbol%3BAcc:HGNC:9411]
ENSG00000006007	51.95	53.61	50.41	49.23	46.69	53.17	0.074293545282606	5.70797938561049	0.288899130894776	0.669461516614105	16:19501688-19522145:-	GDE1	15;GO:0004622,molecular_function lysophospholipase activity;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008889,molecular_function glycerophosphodiester phosphodiesterase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047395,molecular_function glycerophosphoinositol glycerophosphodiesterase activity;GO:0070291,biological_process N-acylethanolamine metabolic process	NA	glycerophosphodiester phosphodiesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:29644]
ENSG00000156170	13.52	15.50	14.09	14.40	15.46	16.83	-0.111591971554699	4.09016243691106	0.288915277894285	0.669461516614105	8:94895766-95116455:+	NDUFAF6	8;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0009058,biological_process biosynthetic process;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NA	NADH:ubiquinone oxidoreductase complex assembly factor 6 [Source:HGNC Symbol%3BAcc:HGNC:28625]
ENSG00000114933	1.35	1.24	1.15	1.19	1.16	0.89	0.225207883584256	1.89759410049456	0.289175748821127	0.669823292599708	2:205993720-206086303:-	INO80D	8;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016579,biological_process protein deubiquitination	NA	INO80 complex subunit D [Source:HGNC Symbol%3BAcc:HGNC:25997]
ENSG00000130813	22.46	21.69	24.25	25.03	22.96	25.59	-0.0910147854048351	4.6389447943187	0.289179330141129	0.669823292599708	19:10086121-10093252:+	C19orf66	9;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0034340,biological_process response to type I interferon;GO:0034341,biological_process response to interferon-gamma;GO:0034342,biological_process response to type III interferon;GO:0045071,biological_process negative regulation of viral genome replication;GO:0051607,biological_process defense response to virus	NA	chromosome 19 open reading frame 66 [Source:HGNC Symbol%3BAcc:HGNC:25649]
ENSG00000099995	37.29	38.68	35.76	40.50	39.24	38.45	-0.0707360344154769	6.51344257169214	0.289236895362773	0.6698316384586	22:30331987-30356947:-	SF3A1	16;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000389,biological_process mRNA 3'-splice site recognition;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005684,cellular_component U2-type spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0071004,cellular_component U2-type prespliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	SF3A1, SAP114; splicing factor 3A subunit 1; K12825	splicing factor 3a subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:10765]
ENSG00000080561	6.66	5.55	6.41	6.72	4.64	5.64	0.147705322332159	3.73187736592783	0.289361487433059	0.66989747377958	X:107825754-107927193:+	MID2	22;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0008270,molecular_function zinc ion binding;GO:0010508,biological_process positive regulation of autophagy;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032897,biological_process negative regulation of viral transcription;GO:0035372,biological_process protein localization to microtubule;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051219,molecular_function phosphoprotein binding;GO:0070062,cellular_component extracellular exosome;GO:1902187,biological_process negative regulation of viral release from host cell	NA	midline 2 [Source:HGNC Symbol%3BAcc:HGNC:7096]
ENSG00000140848	41.70	42.07	40.27	44.77	44.91	41.56	-0.0700312669567641	6.20621030255588	0.289373258229768	0.66989747377958	16:57092536-57148367:+	CPNE2	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome;GO:0071277,biological_process cellular response to calcium ion	NA	copine 2 [Source:HGNC Symbol%3BAcc:HGNC:2315]
ENSG00000149260	7.79	6.32	7.11	6.75	5.87	7.07	0.126383719635968	3.81907440553257	0.289439617355636	0.669926155180964	11:77066931-77126155:+	CAPN5	11;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0009986,cellular_component cell surface;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	calpain 5 [Source:HGNC Symbol%3BAcc:HGNC:1482]
ENSG00000154945	32.31	31.51	32.73	33.77	32.84	36.11	-0.0772288533571546	5.20454137026038	0.28979668677075	0.670627567651999	17:50693189-50707924:-	ANKRD40	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	ankyrin repeat domain 40 [Source:HGNC Symbol%3BAcc:HGNC:28233]
ENSG00000108651	29.25	29.93	26.63	31.61	28.63	30.94	-0.0784449878539887	5.77616036825336	0.289875998123959	0.670678613961455	17:31860898-31901765:-	UTP6	9;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0030515,molecular_function snoRNA binding;GO:0032040,cellular_component small-subunit processome;GO:0034388,cellular_component Pwp2p-containing subcomplex of 90S preribosome	UTP6; U3 small nucleolar RNA-associated protein 6; K14557	UTP6%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:18279]
ENSG00000100442	172.33	172.24	157.68	175.00	181.36	174.64	-0.0691514348566661	7.03258935095689	0.289939925945891	0.670678613961455	14:45115599-45135319:-	FKBP3	10;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005528,molecular_function FK506 binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016853,molecular_function isomerase activity;GO:0061077,biological_process chaperone-mediated protein folding	NA	FK506 binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:3719]
ENSG00000166272	8.86	9.93	9.56	8.52	8.49	9.14	0.121312696126955	3.36037689640876	0.289980836311217	0.670678613961455	10:102743969-102816267:+	WBP1L	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	WW domain binding protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:23510]
ENSG00000160207	3.21	2.84	2.91	4.44	3.08	3.13	-0.229218326799854	1.79475110977033	0.290165589535179	0.670980898453833	21:43529191-43659493:-	HSF2BP	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis	NA	heat shock transcription factor 2 binding protein [Source:HGNC Symbol%3BAcc:HGNC:5226]
ENSG00000164117	13.52	13.46	13.00	10.10	14.37	12.21	0.136030386370125	3.70255533148489	0.290530777622573	0.671674761981466	4:174236657-174284264:-	FBXO8	6;GO:0000151,cellular_component ubiquitin ligase complex;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	F-box protein 8 [Source:HGNC Symbol%3BAcc:HGNC:13587]
ENSG00000137804	69.61	81.12	65.06	73.80	83.01	74.50	-0.0907643626976072	6.70235689283333	0.290573871895631	0.671674761981466	15:41332693-41381050:+	NUSAP1	20;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000281,biological_process mitotic cytokinesis;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0008017,molecular_function microtubule binding;GO:0040001,biological_process establishment of mitotic spindle localization;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0051301,biological_process cell division	NA	nucleolar and spindle associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18538]
ENSG00000091136	199.35	181.26	208.38	186.40	185.51	194.24	0.0690331854942811	10.1304386711352	0.290667629062673	0.671766389788673	7:107923798-108003255:-	LAMB1	25;GO:0005198,molecular_function structural molecule activity;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005606,cellular_component laminin-1 complex;GO:0005607,cellular_component laminin-2 complex;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0021812,biological_process neuronal-glial interaction involved in cerebral cortex radial glia guided migration;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0031012,cellular_component extracellular matrix;GO:0031175,biological_process neuron projection development;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0035987,biological_process endodermal cell differentiation;GO:0042476,biological_process odontogenesis;GO:0043257,cellular_component laminin-8 complex;GO:0043259,cellular_component laminin-10 complex;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0070062,cellular_component extracellular exosome	LAMB1; laminin, beta 1; K05636	laminin subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:6486]
ENSG00000103043	22.88	24.19	24.98	26.56	24.87	24.89	-0.0718313719769309	5.97735416316406	0.290906000681135	0.672192141931297	16:70687438-70801161:-	VAC14	16;GO:0000139,cellular_component Golgi membrane;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007165,biological_process signal transduction;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0031090,cellular_component organelle membrane;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043550,biological_process regulation of lipid kinase activity;GO:0070772,cellular_component PAS complex	VAC14, TAX1BP2; vacuole morphology and inheritance protein 14; K15305	Vac14%2C PIKFYVE complex component [Source:HGNC Symbol%3BAcc:HGNC:25507]
ENSG00000072501	22.61	24.70	21.91	23.79	26.06	23.66	-0.0771236503215433	6.47847188166379	0.291049617266409	0.672294194505438	X:53374148-53422728:-	SMC1A	34;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000794,cellular_component condensed nuclear chromosome;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0008278,cellular_component cohesin complex;GO:0009314,biological_process response to radiation;GO:0016363,cellular_component nuclear matrix;GO:0019827,biological_process stem cell population maintenance;GO:0030893,cellular_component meiotic cohesin complex;GO:0032403,molecular_function protein complex binding;GO:0032876,biological_process negative regulation of DNA endoreduplication;GO:0036033,molecular_function mediator complex binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0072423,biological_process response to DNA damage checkpoint signaling;GO:0097431,cellular_component mitotic spindle pole	SMC1; structural maintenance of chromosome 1; K06636	structural maintenance of chromosomes 1A [Source:HGNC Symbol%3BAcc:HGNC:11111]
ENSG00000136044	15.63	15.91	14.68	14.41	14.56	15.07	0.0783379913002762	5.0223642160682	0.291072157548827	0.672294194505438	12:105173295-105236238:-	APPL2	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016581,cellular_component NuRD complex;GO:0031901,cellular_component early endosome membrane;GO:0070062,cellular_component extracellular exosome	NA	adaptor protein%2C phosphotyrosine interacting with PH domain and leucine zipper 2 [Source:HGNC Symbol%3BAcc:HGNC:18242]
ENSG00000129055	74.44	76.19	76.58	82.29	88.82	75.07	-0.10285301625711	4.14369149068395	0.291112647665087	0.672294194505438	3:134477705-134486716:-	ANAPC13	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005680,cellular_component anaphase-promoting complex;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0051301,biological_process cell division;GO:0070979,biological_process protein K11-linked ubiquitination	NA	anaphase promoting complex subunit 13 [Source:HGNC Symbol%3BAcc:HGNC:24540]
ENSG00000182749	4.49	3.77	5.67	4.47	4.31	3.45	0.215773447475167	2.23202427337759	0.291232648553514	0.672337724704814	1:25861209-25871253:-	PAQR7	11;GO:0003707,molecular_function steroid hormone receptor activity;GO:0005496,molecular_function steroid binding;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0048477,biological_process oogenesis;GO:0048545,biological_process response to steroid hormone	NA	progestin and adipoQ receptor family member 7 [Source:HGNC Symbol%3BAcc:HGNC:23146]
ENSG00000185950	26.02	23.26	27.12	25.05	21.09	26.26	0.0907666246565666	6.64159251286296	0.29124719061564	0.672337724704814	13:109752697-109786568:-	IRS2	47;GO:0000165,biological_process MAPK cascade;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002903,biological_process negative regulation of B cell apoptotic process;GO:0004871,molecular_function signal transducer activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006006,biological_process glucose metabolic process;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0007420,biological_process brain development;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009749,biological_process response to glucose;GO:0010748,biological_process negative regulation of plasma membrane long-chain fatty acid transport;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030335,biological_process positive regulation of cell migration;GO:0030879,biological_process mammary gland development;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0032000,biological_process positive regulation of fatty acid beta-oxidation;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033673,biological_process negative regulation of kinase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0045725,biological_process positive regulation of glycogen biosynthetic process;GO:0046326,biological_process positive regulation of glucose import;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0055088,biological_process lipid homeostasis;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071889,molecular_function 14-3-3 protein binding;GO:1901653,biological_process cellular response to peptide	IRS2; insulin receptor substrate 2; K07187	insulin receptor substrate 2 [Source:HGNC Symbol%3BAcc:HGNC:6126]
ENSG00000139428	33.83	36.51	31.65	31.67	34.74	30.03	0.089213612738631	5.05177412291661	0.291293988839321	0.672337724704814	12:109553736-109573874:-	MMAB	9;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008817,molecular_function cob(I)yrinic acid a,c-diamide adenosyltransferase activity;GO:0009235,biological_process cobalamin metabolic process;GO:0009236,biological_process cobalamin biosynthetic process;GO:0016740,molecular_function transferase activity	MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]; K00798	methylmalonic aciduria (cobalamin deficiency) cblB type [Source:HGNC Symbol%3BAcc:HGNC:19331]
ENSG00000103510	25.52	22.52	24.89	27.21	24.30	26.51	-0.0812293623620561	5.21227851890099	0.291551356090815	0.672806652380608	16:31115753-31131393:+	KAT8	31;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000776,cellular_component kinetochore;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0010506,biological_process regulation of autophagy;GO:0016407,molecular_function acetyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0019899,molecular_function enzyme binding;GO:0030099,biological_process myeloid cell differentiation;GO:0035064,molecular_function methylated histone binding;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific);GO:0071339,cellular_component MLL1 complex;GO:0072487,cellular_component MSL complex	NA	lysine acetyltransferase 8 [Source:HGNC Symbol%3BAcc:HGNC:17933]
ENSG00000177303	4.55	3.54	4.64	3.70	4.20	3.94	0.129090417389779	3.92090541805485	0.291865250382961	0.673361312639055	17:75500260-75515583:-	CASKIN2	5;GO:0003674,molecular_function molecular_function;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane	NA	CASK interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18200]
ENSG00000111331	3.88	3.89	3.22	3.56	3.36	3.22	0.124695341319118	3.58168587639337	0.292010419032851	0.673361312639055	12:112938351-112973249:+	OAS3	26;GO:0000166,molecular_function nucleotide binding;GO:0001730,molecular_function 2'-5'-oligoadenylate synthetase activity;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006955,biological_process immune response;GO:0009615,biological_process response to virus;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0060700,biological_process regulation of ribonuclease activity	OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]; K14216	2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol%3BAcc:HGNC:8088]
ENSG00000138031	18.02	17.71	16.93	19.52	18.31	17.92	-0.0708862756395034	6.01905546748226	0.292010578267176	0.673361312639055	2:24819168-24919839:-	ADCY3	36;GO:0000166,molecular_function nucleotide binding;GO:0003091,biological_process renal water homeostasis;GO:0004016,molecular_function adenylate cyclase activity;GO:0004383,molecular_function guanylate cyclase activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005929,cellular_component cilium;GO:0006171,biological_process cAMP biosynthetic process;GO:0006182,biological_process cGMP biosynthetic process;GO:0007165,biological_process signal transduction;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007338,biological_process single fertilization;GO:0007340,biological_process acrosome reaction;GO:0007608,biological_process sensory perception of smell;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0008355,biological_process olfactory learning;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0030317,biological_process sperm motility;GO:0034199,biological_process activation of protein kinase A activity;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0050896,biological_process response to stimulus;GO:0071377,biological_process cellular response to glucagon stimulus;GO:1904322,biological_process cellular response to forskolin	ADCY3; adenylate cyclase 3 [EC:4.6.1.1]; K08043	adenylate cyclase 3 [Source:HGNC Symbol%3BAcc:HGNC:234]
ENSG00000078061	25.04	26.77	25.08	23.84	25.39	24.35	0.0723979152941655	5.52269878797932	0.292044130970502	0.673361312639055	X:47561099-47571920:+	ARAF	31;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0009968,biological_process negative regulation of signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0020021,biological_process immortalization of host cell;GO:0030154,biological_process cell differentiation;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0032006,biological_process regulation of TOR signaling;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade	ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]; K08845	A-Raf proto-oncogene%2C serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:646]
ENSG00000213516	4.59	4.17	4.15	4.10	4.15	3.25	0.18682539046803	2.29397372831679	0.292069102226377	0.673361312639055	1:88979455-88992960:-	RBMXL1	9;GO:0001047,molecular_function core promoter binding;GO:0003676,molecular_function nucleic acid binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	RBMX, HNRNPG; heterogeneous nuclear ribonucleoprotein G; K12885	RNA binding motif protein%2C X-linked like 1 [Source:HGNC Symbol%3BAcc:HGNC:25073]
ENSG00000087152	32.24	33.18	29.30	29.88	29.92	30.34	0.0798733695324087	5.06198723337557	0.292117189121188	0.673361312639055	17:44191804-44200113:-	ATXN7L3	11;GO:0000124,cellular_component SAGA complex;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016578,biological_process histone deubiquitination;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	ataxin 7 like 3 [Source:HGNC Symbol%3BAcc:HGNC:25416]
ENSG00000196081	0.27	0.51	0.28	0.60	0.57	0.26	-0.469037175178337	-0.13207896640073	0.29224789836201	0.6735375347879	19:23221598-23250390:-	ZNF724	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 724 [Source:HGNC Symbol%3BAcc:HGNC:32460]
ENSG00000164134	18.90	21.51	20.64	20.74	20.82	23.39	-0.0809003739733864	5.92834537952062	0.292440304315847	0.673741713187191	4:139301454-139420033:+	NAA15	21;GO:0001525,biological_process angiogenesis;GO:0003723,molecular_function RNA binding;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006474,biological_process N-terminal protein amino acid acetylation;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016407,molecular_function acetyltransferase activity;GO:0017196,biological_process N-terminal peptidyl-methionine acetylation;GO:0030154,biological_process cell differentiation;GO:0031415,cellular_component NatA complex;GO:0043022,molecular_function ribosome binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050821,biological_process protein stabilization	NA	N(alpha)-acetyltransferase 15%2C NatA auxiliary subunit [Source:HGNC Symbol%3BAcc:HGNC:30782]
ENSG00000236104	12.70	13.47	13.51	15.43	14.16	13.09	-0.0942248904632801	4.71487830835842	0.292477988564196	0.673741713187191	6:33314405-33317942:-	ZBTB22	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 22 [Source:HGNC Symbol%3BAcc:HGNC:13085]
ENSG00000129625	148.03	143.22	146.21	154.09	151.17	156.13	-0.0645869211129507	6.79583209746607	0.29249932267508	0.673741713187191	5:112876378-112922539:-	REEP5	8;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome;GO:0071782,cellular_component endoplasmic reticulum tubular network	NA	receptor accessory protein 5 [Source:HGNC Symbol%3BAcc:HGNC:30077]
ENSG00000163655	53.61	47.48	51.30	54.34	50.45	57.09	-0.0739553263749631	6.77082607820073	0.292593732904581	0.673758002785673	3:155870535-155944026:+	GMPS	13;GO:0000166,molecular_function nucleotide binding;GO:0003921,molecular_function GMP synthase activity;GO:0003922,molecular_function GMP synthase (glutamine-hydrolyzing) activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006177,biological_process GMP biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0009113,biological_process purine nucleobase biosynthetic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016462,molecular_function pyrophosphatase activity;GO:0016874,molecular_function ligase activity	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]; K01951	guanine monophosphate synthase [Source:HGNC Symbol%3BAcc:HGNC:4378]
ENSG00000105202	100.08	99.43	102.84	110.44	100.70	108.69	-0.0691543710651042	6.64683755822656	0.292654620250246	0.673758002785673	19:39834457-39846414:-	FBL	30;GO:0000494,biological_process box C/D snoRNA 3'-end processing;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0001649,biological_process osteoblast differentiation;GO:0001650,cellular_component fibrillar center;GO:0001651,cellular_component dense fibrillar component;GO:0001652,cellular_component granular component;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008649,molecular_function rRNA methyltransferase activity;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016074,biological_process snoRNA metabolic process;GO:0016740,molecular_function transferase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031167,biological_process rRNA methylation;GO:0031428,cellular_component box C/D snoRNP complex;GO:0032040,cellular_component small-subunit processome;GO:0032259,biological_process methylation;GO:0048254,biological_process snoRNA localization;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:1990258,biological_process histone glutamine methylation;GO:1990259,molecular_function histone-glutamine methyltransferase activity	NOP1, FBL; rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-]; K14563	fibrillarin [Source:HGNC Symbol%3BAcc:HGNC:3599]
ENSG00000114354	147.39	147.69	143.08	136.56	144.48	141.66	0.063358855086424	7.46770968535186	0.292701746231169	0.673758002785673	3:100709330-100748966:+	TFG	13;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007165,biological_process signal transduction;GO:0042802,molecular_function identical protein binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048208,biological_process COPII vesicle coating;GO:0070062,cellular_component extracellular exosome;GO:0070971,cellular_component endoplasmic reticulum exit site	TFG; protein TFG; K09292	TRK-fused gene [Source:HGNC Symbol%3BAcc:HGNC:11758]
ENSG00000011275	31.68	29.41	31.67	31.48	32.66	34.06	-0.0690373266136435	6.55893689002317	0.292723508339896	0.673758002785673	7:5620046-5781739:-	RNF216	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032648,biological_process regulation of interferon-beta production;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050691,biological_process regulation of defense response to virus by host;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination	NA	ring finger protein 216 [Source:HGNC Symbol%3BAcc:HGNC:21698]
ENSG00000104064	12.14	10.45	13.27	11.97	11.10	10.34	0.12358097264245	3.95448058196903	0.292889908253444	0.673922904339058	15:50275391-50355408:-	GABPB1	12;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007005,biological_process mitochondrion organization;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity	NA	GA binding protein transcription factor beta subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4074]
ENSG00000128699	89.51	86.01	90.88	82.20	82.93	89.88	0.0759177217050861	5.32800143415989	0.2929037355119	0.673922904339058	2:189770322-189784371:-	ORMDL1	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006672,biological_process ceramide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035339,cellular_component SPOTS complex;GO:0090155,biological_process negative regulation of sphingolipid biosynthetic process;GO:0090156,biological_process cellular sphingolipid homeostasis;GO:1900060,biological_process negative regulation of ceramide biosynthetic process	NA	ORMDL sphingolipid biosynthesis regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:16036]
ENSG00000136514	3.35	1.42	1.60	2.13	2.98	3.14	-0.329399666729952	0.989962721243994	0.293248701153268	0.674473497116528	3:187368331-187372076:+	RTP4	10;GO:0001580,biological_process detection of chemical stimulus involved in sensory perception of bitter taste;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006612,biological_process protein targeting to membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031849,molecular_function olfactory receptor binding;GO:0051205,biological_process protein insertion into membrane;GO:0051607,biological_process defense response to virus	NA	receptor transporter protein 4 [Source:HGNC Symbol%3BAcc:HGNC:23992]
ENSG00000166471	42.87	49.33	51.35	46.37	42.13	47.48	0.08722878158733	5.38340274079282	0.293322833801746	0.674473497116528	11:9280653-9314780:-	TMEM41B	3;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 41B [Source:HGNC Symbol%3BAcc:HGNC:28948]
ENSG00000135341	26.07	26.39	29.19	29.57	29.54	27.73	-0.0755676799546661	5.67970924535495	0.293328261127169	0.674473497116528	6:90513572-90587045:-	MAP3K7	50;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0000287,molecular_function magnesium ion binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002726,biological_process positive regulation of T cell cytokine production;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0007252,biological_process I-kappaB phosphorylation;GO:0007254,biological_process JNK cascade;GO:0008385,cellular_component IkappaB kinase complex;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043276,biological_process anoikis;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043966,biological_process histone H3 acetylation;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050870,biological_process positive regulation of T cell activation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0097110,molecular_function scaffold protein binding	MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]; K04427	mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol%3BAcc:HGNC:6859]
ENSG00000156831	52.85	50.58	49.65	55.06	52.48	54.61	-0.0705979140956165	5.60425473148302	0.293435057468301	0.674473497116528	8:125091678-125367120:+	NSMCE2	23;GO:0000722,biological_process telomere maintenance via recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0030915,cellular_component Smc5-Smc6 complex;GO:0034184,biological_process positive regulation of maintenance of mitotic sister chromatid cohesion;GO:0045842,biological_process positive regulation of mitotic metaphase/anaphase transition;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0090398,biological_process cellular senescence	NA	NSE2/MMS21 homolog%2C SMC5-SMC6 complex SUMO ligase [Source:HGNC Symbol%3BAcc:HGNC:26513]
ENSG00000118482	24.46	24.56	24.10	24.99	26.28	25.76	-0.0634424046688074	7.30636431107517	0.293467389167996	0.674473497116528	6:63635819-63779336:+	PHF3	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0006351,biological_process transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	NA	PHD finger protein 3 [Source:HGNC Symbol%3BAcc:HGNC:8921]
ENSG00000164930	123.21	125.72	127.46	114.82	127.33	120.46	0.0656041130493775	8.03909362425176	0.293521439706794	0.674473497116528	8:103298432-103332866:+	FZD6	37;GO:0001736,biological_process establishment of planar polarity;GO:0001843,biological_process neural tube closure;GO:0001942,biological_process hair follicle development;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007275,biological_process multicellular organism development;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016324,cellular_component apical plasma membrane;GO:0016327,cellular_component apicolateral plasma membrane;GO:0017147,molecular_function Wnt-protein binding;GO:0030168,biological_process platelet activation;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030901,biological_process midbrain development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033278,biological_process cell proliferation in midbrain;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0035880,biological_process embryonic nail plate morphogenesis;GO:0042472,biological_process inner ear morphogenesis;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045177,cellular_component apical part of cell;GO:0048105,biological_process establishment of body hair planar orientation;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1904693,biological_process midbrain morphogenesis	FZD6; frizzled 6; K02376	frizzled class receptor 6 [Source:HGNC Symbol%3BAcc:HGNC:4044]
ENSG00000105373	168.50	154.65	171.72	157.53	144.31	171.28	0.0772093794178049	7.90173257467281	0.293523389303431	0.674473497116528	19:47745521-47757058:+	NOP53	38;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001650,cellular_component fibrillar center;GO:0001932,biological_process regulation of protein phosphorylation;GO:0002039,molecular_function p53 binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0008097,molecular_function 5S rRNA binding;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033553,cellular_component rDNA heterochromatin;GO:0039535,biological_process regulation of RIG-I signaling pathway;GO:0042254,biological_process ribosome biogenesis;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050821,biological_process protein stabilization;GO:0051726,biological_process regulation of cell cycle;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0071456,biological_process cellular response to hypoxia;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1901797,biological_process negative regulation of signal transduction by p53 class mediator;GO:1901837,biological_process negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1902570,biological_process protein localization to nucleolus;GO:1903006,biological_process positive regulation of protein K63-linked deubiquitination;GO:1903715,biological_process regulation of aerobic respiration;GO:1990173,biological_process protein localization to nucleoplasm	NA	NOP53 ribosome biogenesis factor [Source:HGNC Symbol%3BAcc:HGNC:4333]
ENSG00000159111	36.16	36.65	37.22	40.21	37.01	39.75	-0.07716764005139	5.18574378604806	0.293621984182394	0.67457517854082	17:47823271-47831534:-	MRPL10	15;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0042254,biological_process ribosome biogenesis;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10; K02864	mitochondrial ribosomal protein L10 [Source:HGNC Symbol%3BAcc:HGNC:14055]
ENSG00000125457	22.90	17.78	22.27	19.23	18.53	20.95	0.121379182045063	4.16939960072814	0.293726077602137	0.674689452493583	17:75266227-75271227:-	MIF4GD	8;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0008022,molecular_function protein C-terminus binding	NA	MIF4G domain containing [Source:HGNC Symbol%3BAcc:HGNC:24030]
ENSG00000187837	19.45	20.04	20.85	18.86	17.45	19.81	0.114392398842242	3.65031483396088	0.293802757580378	0.674740727075899	6:26055786-26056428:-	HIST1H1C	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005719,cellular_component nuclear euchromatin;GO:0006334,biological_process nucleosome assembly;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016584,biological_process nucleosome positioning;GO:0031490,molecular_function chromatin DNA binding;GO:0035327,cellular_component transcriptionally active chromatin;GO:0080182,biological_process histone H3-K4 trimethylation;GO:0098532,biological_process histone H3-K27 trimethylation	NA	histone cluster 1 H1 family member c [Source:HGNC Symbol%3BAcc:HGNC:4716]
ENSG00000099381	8.76	10.08	9.76	9.01	9.39	8.87	0.0770779183416021	5.5786345104142	0.293877287335566	0.674787045448832	16:30957293-30984664:+	SETD1A	32;GO:0000790,cellular_component nuclear chromatin;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005719,cellular_component nuclear euchromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008168,molecular_function methyltransferase activity;GO:0010628,biological_process positive regulation of gene expression;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0019827,biological_process stem cell population maintenance;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0045646,biological_process regulation of erythrocyte differentiation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1902275,biological_process regulation of chromatin organization;GO:1990188,molecular_function euchromatin binding;GO:2000179,biological_process positive regulation of neural precursor cell proliferation;GO:2000648,biological_process positive regulation of stem cell proliferation	SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]; K11422	SET domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:29010]
ENSG00000107745	62.43	64.51	55.79	59.11	62.53	51.82	0.0860065004407342	6.89340261791488	0.29396027473252	0.674852763132009	10:72367326-72626191:-	MICU1	24;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0006952,biological_process defense response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032592,cellular_component integral component of mitochondrial membrane;GO:0034704,cellular_component calcium channel complex;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051260,biological_process protein homooligomerization;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0070509,biological_process calcium ion import;GO:1990246,cellular_component uniplex complex	NA	mitochondrial calcium uptake 1 [Source:HGNC Symbol%3BAcc:HGNC:1530]
ENSG00000113594	4.94	5.58	5.19	5.60	5.62	5.68	-0.101591159245451	4.17195520499463	0.294114890043603	0.675082864295718	5:38474962-38608354:-	LIFR	23;GO:0001959,biological_process regulation of cytokine-mediated signaling pathway;GO:0004896,molecular_function cytokine receptor activity;GO:0004897,molecular_function ciliary neurotrophic factor receptor activity;GO:0004923,molecular_function leukemia inhibitory factor receptor activity;GO:0004924,molecular_function oncostatin-M receptor activity;GO:0005127,molecular_function ciliary neurotrophic factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019838,molecular_function growth factor binding;GO:0034097,biological_process response to cytokine;GO:0038165,biological_process oncostatin-M-mediated signaling pathway;GO:0043235,cellular_component receptor complex;GO:0048861,biological_process leukemia inhibitory factor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070120,biological_process ciliary neurotrophic factor-mediated signaling pathway	LIFR, CD118; leukemia inhibitory factor receptor; K05058	LIF receptor alpha [Source:HGNC Symbol%3BAcc:HGNC:6597]
ENSG00000163362	2.34	1.87	2.59	3.24	1.79	3.08	-0.231444730007052	2.3635544912459	0.294311153670139	0.675408458219161	1:200891047-200915735:+	INAVA	16;GO:0000187,biological_process activation of MAPK activity;GO:0002221,biological_process pattern recognition receptor signaling pathway;GO:0002367,biological_process cytokine production involved in immune response;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0032494,biological_process response to peptidoglycan;GO:0032495,biological_process response to muramyl dipeptide;GO:0032731,biological_process positive regulation of interleukin-1 beta production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0070431,biological_process nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:1903409,biological_process reactive oxygen species biosynthetic process	NA	innate immunity activator [Source:HGNC Symbol%3BAcc:HGNC:25599]
ENSG00000186260	6.82	7.37	7.09	7.05	8.06	7.68	-0.0904405508848252	4.7753502316551	0.294548930288138	0.675829181454095	16:14071320-14266773:+	MKL2	16;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003779,molecular_function actin binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0030154,biological_process cell differentiation;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045296,molecular_function cadherin binding;GO:0045844,biological_process positive regulation of striated muscle tissue development;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051145,biological_process smooth muscle cell differentiation	NA	MKL1/myocardin like 2 [Source:HGNC Symbol%3BAcc:HGNC:29819]
ENSG00000140678	0.46	0.62	0.64	0.42	0.27	0.66	0.328502618355227	1.0283881202943	0.294651286017526	0.675939089509435	16:31355133-31382997:+	ITGAX	19;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009887,biological_process organ morphogenesis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0030667,cellular_component secretory granule membrane;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0050900,biological_process leukocyte migration;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	ITGAX, CD11c; integrin alpha X; K06462	integrin subunit alpha X [Source:HGNC Symbol%3BAcc:HGNC:6152]
ENSG00000130812	12.02	10.78	13.99	12.00	10.06	12.02	0.127827394003213	4.07555404204914	0.294962619730634	0.676411039660026	19:10092337-10102796:-	ANGPTL6	6;GO:0001525,biological_process angiogenesis;GO:0005576,cellular_component extracellular region;GO:0007275,biological_process multicellular organism development;GO:0030141,cellular_component secretory granule;GO:0030154,biological_process cell differentiation;GO:0070062,cellular_component extracellular exosome	NA	angiopoietin like 6 [Source:HGNC Symbol%3BAcc:HGNC:23140]
ENSG00000132153	18.57	19.55	17.71	17.82	17.85	17.95	0.0675165749289397	6.11765853012749	0.295005858068805	0.676411039660026	3:47802908-47850195:+	DHX30	18;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0016787,molecular_function hydrolase activity;GO:0035770,cellular_component ribonucleoprotein granule;GO:0042254,biological_process ribosome biogenesis;GO:0042645,cellular_component mitochondrial nucleoid;GO:1902775,biological_process mitochondrial large ribosomal subunit assembly	NA	DExH-box helicase 30 [Source:HGNC Symbol%3BAcc:HGNC:16716]
ENSG00000152518	9.10	9.80	8.14	9.19	9.62	10.72	-0.123679194825954	3.82030983405577	0.295020492122725	0.676411039660026	2:43222401-43226609:-	ZFP36L2	38;GO:0000165,biological_process MAPK cascade;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006402,biological_process mRNA catabolic process;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0009611,biological_process response to wounding;GO:0017091,molecular_function AU-rich element binding;GO:0030097,biological_process hemopoiesis;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033077,biological_process T cell differentiation in thymus;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0043488,biological_process regulation of mRNA stability;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045577,biological_process regulation of B cell differentiation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048103,biological_process somatic stem cell division;GO:0060216,biological_process definitive hemopoiesis;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0097011,biological_process cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1901991,biological_process negative regulation of mitotic cell cycle phase transition;GO:1904628,biological_process cellular response to phorbol 13-acetate 12-myristate;GO:2000737,biological_process negative regulation of stem cell differentiation	NA	ZFP36 ring finger protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:1108]
ENSG00000157214	5.32	3.17	4.65	4.21	3.68	3.77	0.203997963884525	2.74153681090109	0.295191185885761	0.676677412816242	7:90167589-90238137:+	STEAP2	24;GO:0005215,molecular_function transporter activity;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006811,biological_process ion transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0006897,biological_process endocytosis;GO:0008823,molecular_function cupric reductase activity;GO:0009725,biological_process response to hormone;GO:0010008,cellular_component endosome membrane;GO:0015677,biological_process copper ion import;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030173,cellular_component integral component of Golgi membrane;GO:0045055,biological_process regulated exocytosis;GO:0046872,molecular_function metal ion binding;GO:0052851,molecular_function ferric-chelate reductase (NADPH) activity;GO:0055072,biological_process iron ion homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0098706,biological_process ferric iron import across plasma membrane	STEAP2; metalloreductase STEAP2 [EC:1.16.1.-]; K14738	STEAP2 metalloreductase [Source:HGNC Symbol%3BAcc:HGNC:17885]
ENSG00000124788	7.97	7.54	7.16	8.64	8.62	7.36	-0.104297219433378	4.28124405329185	0.295409211369745	0.676924492630608	6:16299111-16761491:-	ATXN1	21;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0008022,molecular_function protein C-terminus binding;GO:0008266,molecular_function poly(U) RNA binding;GO:0016363,cellular_component nuclear matrix;GO:0034046,molecular_function poly(G) binding;GO:0042272,cellular_component nuclear RNA export factor complex;GO:0042405,cellular_component nuclear inclusion body;GO:0042802,molecular_function identical protein binding;GO:0043621,molecular_function protein self-association;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051168,biological_process nuclear export	NA	ataxin 1 [Source:HGNC Symbol%3BAcc:HGNC:10548]
ENSG00000114021	42.03	45.39	39.03	38.02	42.38	39.96	0.0792726835680458	5.5747160332382	0.295445228100797	0.676924492630608	3:100334700-100361635:+	NIT2	16;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006528,biological_process asparagine metabolic process;GO:0006541,biological_process glutamine metabolic process;GO:0006807,biological_process nitrogen compound metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0050152,molecular_function omega-amidase activity;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen	NIT2, yafV; omega-amidase [EC:3.5.1.3]; K13566	nitrilase family member 2 [Source:HGNC Symbol%3BAcc:HGNC:29878]
ENSG00000100731	12.17	10.84	11.10	10.95	10.91	10.94	0.0706854735182469	6.33527600281292	0.295462571584036	0.676924492630608	14:70907404-71115382:+	PCNX1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	pecanex homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:19740]
ENSG00000175575	21.04	24.99	20.12	21.20	20.26	20.80	0.0914777781343517	4.93914058345989	0.29556946658618	0.677044434163914	11:73876698-73931124:+	PAAF1	5;GO:0000502,cellular_component proteasome complex;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process	NA	proteasomal ATPase associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:25687]
ENSG00000182899	1229.47	1089.96	1147.35	1263.96	1143.70	1264.27	-0.0708030494945252	8.6532035684671	0.295645872542263	0.67709450477253	3:197949986-197956610:+	RPL35A	20;GO:0000049,molecular_function tRNA binding;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein L35a [Source:HGNC Symbol%3BAcc:HGNC:10345]
ENSG00000124613	6.44	5.25	6.58	7.74	6.00	6.94	-0.155099211814617	2.84227356397336	0.295802526059846	0.677328307688779	6:27374614-27403904:+	ZNF391	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 391 [Source:HGNC Symbol%3BAcc:HGNC:18779]
ENSG00000171161	7.97	6.20	7.22	4.97	6.77	7.47	0.173602840393818	3.22831239633096	0.295926359287634	0.677486886358797	1:248838209-248849517:+	ZNF672	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 672 [Source:HGNC Symbol%3BAcc:HGNC:26179]
ENSG00000105281	286.46	233.17	276.47	294.52	264.62	291.17	-0.0828567760486022	8.90749679294304	0.296125566096855	0.677657756976985	19:46774882-46788594:-	SLC1A5	24;GO:0001618,molecular_function virus receptor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0006868,biological_process glutamine transport;GO:0010585,biological_process glutamine secretion;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015186,molecular_function L-glutamine transmembrane transporter activity;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015804,biological_process neutral amino acid transport;GO:0015825,biological_process L-serine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0042470,cellular_component melanosome;GO:0046718,biological_process viral entry into host cell;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1903803,biological_process L-glutamine import into cell	SLC1A5; solute carrier family 1 (neutral amino acid transporter), member 5; K05616	solute carrier family 1 member 5 [Source:HGNC Symbol%3BAcc:HGNC:10943]
ENSG00000182247	48.76	49.32	56.56	48.87	48.45	49.92	0.0842300263352834	5.18029884384448	0.296129949587675	0.677657756976985	3:23203019-23591793:+	UBE2E2	14;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032020,biological_process ISG15-protein conjugation;GO:0042296,molecular_function ISG15 transferase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle	NA	ubiquitin conjugating enzyme E2 E2 [Source:HGNC Symbol%3BAcc:HGNC:12478]
ENSG00000134987	12.43	12.93	12.74	12.26	11.24	12.82	0.0783359557982662	5.15143352352895	0.296164773350531	0.677657756976985	5:111091715-111130502:+	WDR36	14;GO:0001895,biological_process retina homeostasis;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0007601,biological_process visual perception;GO:0008150,biological_process biological_process;GO:0030516,biological_process regulation of axon extension;GO:0032040,cellular_component small-subunit processome;GO:0034388,cellular_component Pwp2p-containing subcomplex of 90S preribosome;GO:0042254,biological_process ribosome biogenesis;GO:0050896,biological_process response to stimulus	UTP21, WDR36; U3 small nucleolar RNA-associated protein 21; K14554	WD repeat domain 36 [Source:HGNC Symbol%3BAcc:HGNC:30696]
ENSG00000117009	72.57	65.72	75.23	64.46	67.13	72.77	0.0766806101915034	6.70032084724039	0.296224688072891	0.67766993237169	1:241532133-241595642:+	KMO	23;GO:0004497,molecular_function monooxygenase activity;GO:0004502,molecular_function kynurenine 3-monooxygenase activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006569,biological_process tryptophan catabolic process;GO:0009435,biological_process NAD biosynthetic process;GO:0009651,biological_process response to salt stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016174,molecular_function NAD(P)H oxidase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0019441,biological_process tryptophan catabolic process to kynurenine;GO:0019674,biological_process NAD metabolic process;GO:0019805,biological_process quinolinate biosynthetic process;GO:0044550,biological_process secondary metabolite biosynthetic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070189,biological_process kynurenine metabolic process;GO:0071949,molecular_function FAD binding	KMO; kynurenine 3-monooxygenase [EC:1.14.13.9]; K00486	kynurenine 3-monooxygenase [Source:HGNC Symbol%3BAcc:HGNC:6381]
ENSG00000157020	85.42	95.65	77.01	79.25	85.70	80.32	0.082778749582621	6.58845552999245	0.296442304902814	0.678042810163741	3:10293130-10321178:-	SEC13	32;GO:0000139,cellular_component Golgi membrane;GO:0000776,cellular_component kinetochore;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007062,biological_process sister chromatid cohesion;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030127,cellular_component COPII vesicle coat;GO:0031080,cellular_component nuclear pore outer ring;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032008,biological_process positive regulation of TOR signaling;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048208,biological_process COPII vesicle coating;GO:0051028,biological_process mRNA transport;GO:0061700,cellular_component GATOR2 complex;GO:0070062,cellular_component extracellular exosome;GO:0090110,biological_process cargo loading into COPII-coated vesicle	SEC13; protein transport protein SEC13; K14004	SEC13 homolog%2C nuclear pore and COPII coat complex component [Source:HGNC Symbol%3BAcc:HGNC:10697]
ENSG00000138175	90.03	102.74	80.48	85.02	85.70	87.83	0.0862051010382043	5.59892180218224	0.2968122304652	0.678763857178431	10:102673730-102714407:-	ARL3	36;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0001822,biological_process kidney development;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0007049,biological_process cell cycle;GO:0007224,biological_process smoothened signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008017,molecular_function microtubule binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030496,cellular_component midbody;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0042073,biological_process intraciliary transport;GO:0042461,biological_process photoreceptor cell development;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome	NA	ADP ribosylation factor like GTPase 3 [Source:HGNC Symbol%3BAcc:HGNC:694]
ENSG00000148426	9.42	6.59	8.69	11.19	6.63	10.72	-0.189998515704732	3.56522514903912	0.29714473056893	0.67933797794393	10:11823338-11872277:+	PROSER2	1;GO:0005515,molecular_function protein binding	NA	proline and serine rich 2 [Source:HGNC Symbol%3BAcc:HGNC:23728]
ENSG00000103226	7.26	8.53	7.00	6.55	7.03	7.80	0.0964093292656837	4.90462880267646	0.297218307684857	0.67933797794393	16:16232494-16294814:+	NOMO3	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding	NA	NODAL modulator 3 [Source:HGNC Symbol%3BAcc:HGNC:25242]
ENSG00000106609	129.56	144.26	133.14	134.88	128.98	126.60	0.0698562286206129	6.9698609562134	0.297292308324168	0.67933797794393	7:66921224-66958551:+	TMEM248	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 248 [Source:HGNC Symbol%3BAcc:HGNC:25476]
ENSG00000070010	37.88	41.71	37.40	41.95	43.40	39.32	-0.083711020727981	5.21827627695156	0.297308760001435	0.67933797794393	22:19449909-19479215:-	UFD1	22;GO:0001501,biological_process skeletal system development;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016579,biological_process protein deubiquitination;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0032403,molecular_function protein complex binding;GO:0032480,biological_process negative regulation of type I interferon production;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0036435,molecular_function K48-linked polyubiquitin binding;GO:0036501,cellular_component UFD1-NPL4 complex;GO:0039536,biological_process negative regulation of RIG-I signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051117,molecular_function ATPase binding;GO:0070987,biological_process error-free translesion synthesis;GO:0071712,biological_process ER-associated misfolded protein catabolic process	UFD1; ubiquitin fusion degradation protein 1; K14016	ubiquitin recognition factor in ER associated degradation 1 [Source:HGNC Symbol%3BAcc:HGNC:12520]
ENSG00000112320	0.88	0.40	0.81	0.96	0.72	0.96	-0.286539348398249	1.18690468614621	0.29733692372266	0.67933797794393	6:107489957-107660167:+	SOBP	8;GO:0005634,cellular_component nucleus;GO:0007605,biological_process sensory perception of sound;GO:0007626,biological_process locomotory behavior;GO:0032184,molecular_function SUMO polymer binding;GO:0042472,biological_process inner ear morphogenesis;GO:0046872,molecular_function metal ion binding;GO:0050890,biological_process cognition;GO:0090102,biological_process cochlea development	NA	sine oculis binding protein homolog [Source:HGNC Symbol%3BAcc:HGNC:29256]
ENSG00000167775	31.70	31.79	28.06	27.12	28.75	30.74	0.0882564645839478	4.82066086548297	0.297537025671764	0.679670058826574	19:8302126-8308356:-	CD320	18;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0008083,molecular_function growth factor activity;GO:0009235,biological_process cobalamin metabolic process;GO:0010008,cellular_component endosome membrane;GO:0015235,molecular_function cobalamin transporter activity;GO:0015889,biological_process cobalamin transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030656,biological_process regulation of vitamin metabolic process;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031296,biological_process B cell costimulation;GO:0031419,molecular_function cobalamin binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	CD320 molecule [Source:HGNC Symbol%3BAcc:HGNC:16692]
ENSG00000141404	0.98	1.15	0.79	1.42	0.81	1.42	-0.332947402913121	0.916289127056591	0.297631076128519	0.679759806436671	18:11688955-11885685:+	GNAL	18;GO:0000166,molecular_function nucleotide binding;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005525,molecular_function GTP binding;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007191,biological_process adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007608,biological_process sensory perception of smell;GO:0019001,molecular_function guanyl nucleotide binding;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	GNAL; guanine nucleotide-binding protein G(olf) subunit alpha; K04633	G protein subunit alpha L [Source:HGNC Symbol%3BAcc:HGNC:4388]
ENSG00000212123	0.87	1.18	0.64	1.30	0.93	1.12	-0.340808026380545	0.61654883606847	0.297734731496253	0.679871453653972	19:5782959-5784765:-	PRR22	NA	NA	proline rich 22 [Source:HGNC Symbol%3BAcc:HGNC:28354]
ENSG00000132275	7.77	8.69	9.08	9.45	8.24	10.41	-0.130514773126298	3.6837159031646	0.297957354814477	0.680254670831727	11:6595074-6603620:-	RRP8	23;GO:0000183,biological_process chromatin silencing at rDNA;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005677,cellular_component chromatin silencing complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0033553,cellular_component rDNA heterochromatin;GO:0035064,molecular_function methylated histone binding;GO:0042149,biological_process cellular response to glucose starvation;GO:0046015,biological_process regulation of transcription by glucose;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	NA	ribosomal RNA processing 8 [Source:HGNC Symbol%3BAcc:HGNC:29030]
ENSG00000215790	7.20	6.54	5.95	7.26	8.58	6.56	-0.169725092802866	2.53628968684319	0.298187199790468	0.680654231518772	1:1724837-1745992:-	SLC35E2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member E2 [Source:HGNC Symbol%3BAcc:HGNC:20863]
ENSG00000130066	326.03	260.58	324.87	303.32	240.78	310.10	0.106091199929983	7.8099155981144	0.298258239560468	0.680691216706029	X:23783172-23786226:+	SAT1	17;GO:0001525,biological_process angiogenesis;GO:0004145,molecular_function diamine N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0006598,biological_process polyamine catabolic process;GO:0008080,molecular_function N-acetyltransferase activity;GO:0009447,biological_process putrescine catabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019809,molecular_function spermidine binding;GO:0032918,biological_process spermidine acetylation;GO:0042127,biological_process regulation of cell proliferation;GO:0046208,biological_process spermine catabolic process	speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]; K00657	spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:10540]
ENSG00000069869	5.52	5.30	5.50	4.15	5.29	5.76	0.113841283538633	4.49969973841572	0.298461402482653	0.680913683846501	15:55826921-55993746:-	NEDD4	63;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000785,cellular_component chromatin;GO:0002250,biological_process adaptive immune response;GO:0003151,biological_process outflow tract morphogenesis;GO:0003197,biological_process endocardial cushion development;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006513,biological_process protein monoubiquitination;GO:0006622,biological_process protein targeting to lysosome;GO:0007041,biological_process lysosomal transport;GO:0007399,biological_process nervous system development;GO:0007528,biological_process neuromuscular junction development;GO:0010766,biological_process negative regulation of sodium ion transport;GO:0010768,biological_process negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016241,biological_process regulation of macroautophagy;GO:0016327,cellular_component apicolateral plasma membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019089,biological_process transmission of virus;GO:0019871,molecular_function sodium channel inhibitor activity;GO:0019904,molecular_function protein domain specific binding;GO:0030948,biological_process negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031175,biological_process neuron projection development;GO:0031623,biological_process receptor internalization;GO:0031698,molecular_function beta-2 adrenergic receptor binding;GO:0032801,biological_process receptor catabolic process;GO:0034644,biological_process cellular response to UV;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0042110,biological_process T cell activation;GO:0042391,biological_process regulation of membrane potential;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043197,cellular_component dendritic spine;GO:0044111,biological_process development involved in symbiotic interaction;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046824,biological_process positive regulation of nucleocytoplasmic transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048514,biological_process blood vessel morphogenesis;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0050807,biological_process regulation of synapse organization;GO:0050815,molecular_function phosphoserine binding;GO:0050816,molecular_function phosphothreonine binding;GO:0050847,biological_process progesterone receptor signaling pathway;GO:0051592,biological_process response to calcium ion;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0070063,molecular_function RNA polymerase binding;GO:0070064,molecular_function proline-rich region binding;GO:0070534,biological_process protein K63-linked ubiquitination;GO:1901016,biological_process regulation of potassium ion transmembrane transporter activity;GO:2000650,biological_process negative regulation of sodium ion transmembrane transporter activity	NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]; K10591	neural precursor cell expressed%2C developmentally down-regulated 4%2C E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:7727]
ENSG00000165527	207.57	201.14	236.22	235.88	217.85	232.25	-0.076001012416116	6.86728857871644	0.298465427681367	0.680913683846501	14:49893091-49897054:+	ARF6	54;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0001889,biological_process liver development;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0006928,biological_process movement of cell or subcellular component;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007399,biological_process nervous system development;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030139,cellular_component endocytic vesicle;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031527,cellular_component filopodium membrane;GO:0031529,biological_process ruffle organization;GO:0031996,molecular_function thioesterase binding;GO:0032154,cellular_component cleavage furrow;GO:0033028,biological_process myeloid cell apoptotic process;GO:0034394,biological_process protein localization to cell surface;GO:0035020,biological_process regulation of Rac protein signal transduction;GO:0036010,biological_process protein localization to endosome;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0047485,molecular_function protein N-terminus binding;GO:0048261,biological_process negative regulation of receptor-mediated endocytosis;GO:0051301,biological_process cell division;GO:0051489,biological_process regulation of filopodium assembly;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0060998,biological_process regulation of dendritic spine development;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0090162,biological_process establishment of epithelial cell polarity;GO:0090543,cellular_component Flemming body;GO:0097284,biological_process hepatocyte apoptotic process;GO:2000171,biological_process negative regulation of dendrite development	NA	ADP ribosylation factor 6 [Source:HGNC Symbol%3BAcc:HGNC:659]
ENSG00000139211	174.90	145.55	168.92	160.84	137.93	165.74	0.087697009327598	7.96224518651948	0.298647473690319	0.681116980204827	12:47075706-47079951:-	AMIGO2	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043069,biological_process negative regulation of programmed cell death;GO:0051965,biological_process positive regulation of synapse assembly	NA	adhesion molecule with Ig like domain 2 [Source:HGNC Symbol%3BAcc:HGNC:24073]
ENSG00000109586	18.37	17.00	15.64	16.04	16.56	15.99	0.0826093384819972	5.19913939597762	0.298695530232754	0.681116980204827	4:173168752-173323967:+	GALNT7	14;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:4129]
ENSG00000089280	193.03	215.61	185.80	204.16	223.59	203.57	-0.0757602595380788	8.33655420988485	0.298797822375051	0.681116980204827	16:31180109-31194871:+	FUS	25;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030331,molecular_function estrogen receptor binding;GO:0030425,cellular_component dendrite;GO:0031489,molecular_function myosin V binding;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0042802,molecular_function identical protein binding;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043204,cellular_component perikaryon;GO:0044327,cellular_component dendritic spine head;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071277,biological_process cellular response to calcium ion	TLS, FUS; RNA-binding protein FUS; K13098	FUS RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:4010]
ENSG00000104408	404.65	384.96	394.68	385.57	373.14	387.10	0.0595819855239533	9.2095650180947	0.298818183729676	0.681116980204827	8:108201215-108435333:-	EIF3E	25;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000785,cellular_component chromatin;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016020,cellular_component membrane;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0045296,molecular_function cadherin binding;GO:0045727,biological_process positive regulation of translation;GO:0045947,biological_process negative regulation of translational initiation;GO:0047485,molecular_function protein N-terminus binding;GO:0070062,cellular_component extracellular exosome;GO:1902416,biological_process positive regulation of mRNA binding	EIF3E, INT6; translation initiation factor 3 subunit E; K03250	eukaryotic translation initiation factor 3 subunit E [Source:HGNC Symbol%3BAcc:HGNC:3277]
ENSG00000146842	14.94	15.95	18.25	15.47	14.50	16.39	0.0957686578247121	4.86100289877528	0.298853112334968	0.681116980204827	7:130164714-130207770:-	TMEM209	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 209 [Source:HGNC Symbol%3BAcc:HGNC:21898]
ENSG00000166860	2.78	2.28	1.62	1.82	2.17	1.78	0.225520834647628	2.19358769634245	0.298883766307556	0.681116980204827	12:56998833-57006446:-	ZBTB39	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 39 [Source:HGNC Symbol%3BAcc:HGNC:29014]
ENSG00000066455	36.30	36.17	38.46	34.41	35.93	36.46	0.0669793626147072	6.31814315516926	0.299243917014509	0.6817133880404	14:92794230-92839963:+	GOLGA5	12;GO:0000139,cellular_component Golgi membrane;GO:0000301,biological_process retrograde transport, vesicle recycling within Golgi;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030133,cellular_component transport vesicle;GO:0031985,cellular_component Golgi cisterna;GO:0042803,molecular_function protein homodimerization activity;GO:0048193,biological_process Golgi vesicle transport	NA	golgin A5 [Source:HGNC Symbol%3BAcc:HGNC:4428]
ENSG00000173226	19.05	15.29	19.04	19.78	17.97	19.87	-0.0915183119480127	5.06485174865342	0.299255317121738	0.6817133880404	3:121769762-121835079:-	IQCB1	17;GO:0001750,cellular_component photoreceptor outer segment;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0019899,molecular_function enzyme binding;GO:0030030,biological_process cell projection organization;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0045494,biological_process photoreceptor cell maintenance;GO:0048496,biological_process maintenance of organ identity;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	IQ motif containing B1 [Source:HGNC Symbol%3BAcc:HGNC:28949]
ENSG00000183495	10.76	10.64	10.71	11.55	11.22	11.09	-0.0646054820040848	6.71016807335561	0.299324079843348	0.681733222192346	12:131949919-132081102:+	EP400	16;GO:0000166,molecular_function nucleotide binding;GO:0000812,cellular_component Swr1 complex;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:1990405,molecular_function protein antigen binding	NA	E1A binding protein p400 [Source:HGNC Symbol%3BAcc:HGNC:11958]
ENSG00000196428	18.34	19.15	18.18	16.92	19.18	17.02	0.0781014708470232	5.43601656336835	0.299373865638482	0.681733222192346	3:150408334-150466431:+	TSC22D2	5;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006970,biological_process response to osmotic stress	NA	TSC22 domain family member 2 [Source:HGNC Symbol%3BAcc:HGNC:29095]
ENSG00000167685	9.78	9.44	9.37	10.67	10.12	10.67	-0.125569106430007	3.32211058451109	0.299585247737582	0.682028876512957	19:56132598-56160893:+	ZNF444	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 444 [Source:HGNC Symbol%3BAcc:HGNC:16052]
ENSG00000144182	8.52	7.34	7.96	7.16	7.18	7.60	0.137199634239587	3.12264683851237	0.299613587660127	0.682028876512957	2:99154954-99163157:+	LIPT1	9;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006464,biological_process cellular protein modification process;GO:0006629,biological_process lipid metabolic process;GO:0009249,biological_process protein lipoylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016979,molecular_function lipoate-protein ligase activity;GO:0034641,biological_process cellular nitrogen compound metabolic process	LIPT1; lipoyltransferase 1; K10105	lipoyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:29569]
ENSG00000167699	27.25	26.64	27.34	28.00	28.64	29.15	-0.0663689549237043	5.76353497303259	0.299690866028457	0.682079706639391	17:757096-783390:-	GLOD4	3;GO:0005739,cellular_component mitochondrion;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	NA	glyoxalase domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:14111]
ENSG00000107438	391.98	361.83	370.76	370.49	341.18	371.82	0.0657412950978366	8.50646108117622	0.299748228713399	0.682085199453607	10:95237571-95291024:-	PDLIM1	12;GO:0001666,biological_process response to hypoxia;GO:0003713,molecular_function transcription coactivator activity;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006979,biological_process response to oxidative stress;GO:0046872,molecular_function metal ion binding;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	NA	PDZ and LIM domain 1 [Source:HGNC Symbol%3BAcc:HGNC:2067]
ENSG00000151881	42.20	35.08	38.89	47.27	38.79	40.07	-0.101046947634616	4.72937780818951	0.299809145474216	0.68208684926272	5:43444251-43483893:-	TMEM267	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 267 [Source:HGNC Symbol%3BAcc:HGNC:26139]
ENSG00000181666	9.20	7.98	9.11	10.78	8.11	9.79	-0.109555467122899	4.68353352842143	0.299897133047378	0.68208684926272	19:37312836-37369365:+	HKR1	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	HKR1%2C GLI-Kruppel zinc finger family member [Source:HGNC Symbol%3BAcc:HGNC:4928]
ENSG00000198964	8.59	9.63	7.47	7.43	8.94	6.98	0.143000302265284	3.46557656814293	0.299917837587908	0.68208684926272	10:50305585-50625163:-	SGMS1	11;GO:0002950,molecular_function ceramide phosphoethanolamine synthase activity;GO:0006954,biological_process inflammatory response;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0033188,molecular_function sphingomyelin synthase activity;GO:0046513,biological_process ceramide biosynthetic process;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	sphingomyelin synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:29799]
ENSG00000175662	10.16	10.04	9.75	9.52	9.33	9.36	0.0980823748351272	4.03450935016686	0.300004616166293	0.68208684926272	17:17843510-17972422:-	TOM1L2	10;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0015031,biological_process protein transport;GO:0019901,molecular_function protein kinase binding;GO:0030276,molecular_function clathrin binding;GO:0045839,biological_process negative regulation of mitotic nuclear division;GO:0070062,cellular_component extracellular exosome	NA	target of myb1 like 2 membrane trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:11984]
ENSG00000198040	13.38	11.89	11.79	10.76	12.99	11.24	0.0978168562050218	4.87451067937422	0.300027523067447	0.68208684926272	12:133037291-133063304:+	ZNF84	20;GO:0001570,biological_process vasculogenesis;GO:0001822,biological_process kidney development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006807,biological_process nitrogen compound metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009791,biological_process post-embryonic development;GO:0014909,biological_process smooth muscle cell migration;GO:0030097,biological_process hemopoiesis;GO:0035264,biological_process multicellular organism growth;GO:0046872,molecular_function metal ion binding;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048705,biological_process skeletal system morphogenesis;GO:0048745,biological_process smooth muscle tissue development;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 84 [Source:HGNC Symbol%3BAcc:HGNC:13159]
ENSG00000131495	134.35	156.46	119.34	141.24	155.99	143.96	-0.0987694425336569	5.49408213864757	0.300166030688625	0.68208684926272	5:140638739-140647785:-	NDUFA2	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2; K03946	NADH:ubiquinone oxidoreductase subunit A2 [Source:HGNC Symbol%3BAcc:HGNC:7685]
ENSG00000101888	8.96	12.13	9.59	8.87	13.86	12.73	-0.210039695599025	2.73190013982886	0.300166879090301	0.68208684926272	X:109535780-109544690:+	NXT2	10;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051028,biological_process mRNA transport	NXT1_2, P15; NTF2-related export protein 1/2; K14285	nuclear transport factor 2 like export factor 2 [Source:HGNC Symbol%3BAcc:HGNC:18151]
ENSG00000244005	13.47	12.23	12.15	13.13	13.20	14.44	-0.0935429154874589	4.37010569234216	0.300232887029949	0.68208684926272	20:35668054-35699359:-	NFS1	21;GO:0000096,biological_process sulfur amino acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006461,biological_process protein complex assembly;GO:0006777,biological_process Mo-molybdopterin cofactor biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0018283,biological_process iron incorporation into metallo-sulfur cluster;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0031071,molecular_function cysteine desulfurase activity;GO:0032324,biological_process molybdopterin cofactor biosynthetic process;GO:0042803,molecular_function protein homodimerization activity;GO:0044281,biological_process small molecule metabolic process;GO:0044571,biological_process [2Fe-2S] cluster assembly;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding	iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]; K04487	NFS1%2C cysteine desulfurase [Source:HGNC Symbol%3BAcc:HGNC:15910]
ENSG00000138496	16.36	16.17	15.92	17.34	16.49	17.47	-0.0713441515682303	5.44697686694238	0.300243498297873	0.68208684926272	3:122527923-122564577:-	PARP9	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001191,molecular_function transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0060330,biological_process regulation of response to interferon-gamma	NA	poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol%3BAcc:HGNC:24118]
ENSG00000111344	1.14	0.47	1.03	0.81	0.44	0.87	0.361490238255864	1.07889218269941	0.300488364740256	0.682430258884209	12:113098818-113136239:-	RASAL1	14;GO:0000165,biological_process MAPK cascade;GO:0005096,molecular_function GTPase activator activity;GO:0005543,molecular_function phospholipid binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0030154,biological_process cell differentiation;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0035556,biological_process intracellular signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding;GO:1903861,biological_process positive regulation of dendrite extension	NA	RAS protein activator like 1 [Source:HGNC Symbol%3BAcc:HGNC:9873]
ENSG00000067704	79.19	82.31	77.26	74.72	79.26	76.34	0.0631558823615713	7.89257792234357	0.300557484969598	0.682430258884209	1:220094101-220148041:+	IARS2	15;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004822,molecular_function isoleucine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006428,biological_process isoleucyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0016874,molecular_function ligase activity	IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]; K01870	isoleucyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:29685]
ENSG00000183943	3.42	3.92	2.60	3.90	4.17	3.47	-0.217298669576257	1.99281711217427	0.300559592791426	0.682430258884209	X:3604369-3713608:-	PRKX	27;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001935,biological_process endothelial cell proliferation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004691,molecular_function cAMP-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030099,biological_process myeloid cell differentiation;GO:0030154,biological_process cell differentiation;GO:0030155,biological_process regulation of cell adhesion;GO:0030334,biological_process regulation of cell migration;GO:0031589,biological_process cell-substrate adhesion;GO:0043542,biological_process endothelial cell migration;GO:0046777,biological_process protein autophosphorylation;GO:0060562,biological_process epithelial tube morphogenesis;GO:0060993,biological_process kidney morphogenesis;GO:2000696,biological_process regulation of epithelial cell differentiation involved in kidney development	NA	protein kinase%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:9441]
ENSG00000186416	7.71	9.40	8.21	8.81	9.25	9.24	-0.106995304282831	4.22294246259912	0.300865857692909	0.683000711693869	X:119588336-119605895:-	NKRF	13;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	NFKB repressing factor [Source:HGNC Symbol%3BAcc:HGNC:19374]
ENSG00000141098	8.62	7.23	6.95	8.86	8.12	8.22	-0.126756929293201	3.44214294174916	0.300998365297815	0.683176578614332	16:67674530-67719421:-	GFOD2	5;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0016491,molecular_function oxidoreductase activity;GO:0030198,biological_process extracellular matrix organization;GO:0055114,biological_process oxidation-reduction process	NA	glucose-fructose oxidoreductase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28159]
ENSG00000104365	10.18	10.75	11.21	10.64	9.55	10.36	0.0839306387064099	4.90042806775236	0.301096143310657	0.683192091106682	8:42271301-42332653:+	IKBKB	51;GO:0000166,molecular_function nucleotide binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007252,biological_process I-kappaB phosphorylation;GO:0008384,molecular_function IkappaB kinase activity;GO:0008385,cellular_component IkappaB kinase complex;GO:0009615,biological_process response to virus;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0035509,biological_process negative regulation of myosin-light-chain-phosphatase activity;GO:0035631,cellular_component CD40 receptor complex;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042325,biological_process regulation of phosphorylation;GO:0042501,biological_process serine phosphorylation of STAT protein;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0097110,molecular_function scaffold protein binding;GO:1903140,biological_process regulation of establishment of endothelial barrier;GO:1903347,biological_process negative regulation of bicellular tight junction assembly	NA	inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol%3BAcc:HGNC:5960]
ENSG00000168234	4.77	5.61	5.73	5.79	5.94	5.94	-0.127562496085631	3.46922328373484	0.301143945627919	0.683192091106682	18:23992772-24135610:+	TTC39C	NA	NA	tetratricopeptide repeat domain 39C [Source:HGNC Symbol%3BAcc:HGNC:26595]
ENSG00000167552	117.98	169.46	115.14	131.82	187.09	132.24	-0.153198247329686	7.74553684060107	0.301170315196629	0.683192091106682	12:49184795-49189324:-	TUBA1A	26;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019904,molecular_function protein domain specific binding;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0043209,cellular_component myelin sheath;GO:0045121,cellular_component membrane raft;GO:0051301,biological_process cell division;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	TUBA; tubulin alpha; K07374	tubulin alpha 1a [Source:HGNC Symbol%3BAcc:HGNC:20766]
ENSG00000185825	181.49	200.39	183.96	178.29	179.87	186.32	0.0660215119444554	7.44264314832699	0.301240961594122	0.683227490639107	X:153700496-153724697:-	BCAP31	36;GO:0000139,cellular_component Golgi membrane;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005784,cellular_component Sec61 translocon complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006915,biological_process apoptotic process;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007283,biological_process spermatogenesis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030136,cellular_component clathrin-coated vesicle;GO:0032403,molecular_function protein complex binding;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0042288,molecular_function MHC class I protein binding;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0070973,biological_process protein localization to endoplasmic reticulum exit site;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:0097038,cellular_component perinuclear endoplasmic reticulum;GO:0097194,biological_process execution phase of apoptosis;GO:1903071,biological_process positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1904154,biological_process positive regulation of retrograde protein transport, ER to cytosol;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BCAP31, BAP31; B-cell receptor-associated protein 31; K14009	B-cell receptor associated protein 31 [Source:HGNC Symbol%3BAcc:HGNC:16695]
ENSG00000090273	116.67	115.19	105.32	118.58	118.58	118.95	-0.0676471250712628	6.97392315458578	0.301359205080706	0.683370809767411	1:26900237-26946862:+	NUDC	17;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045296,molecular_function cadherin binding;GO:0051082,molecular_function unfolded protein binding;GO:0051301,biological_process cell division	NA	nuclear distribution C%2C dynein complex regulator [Source:HGNC Symbol%3BAcc:HGNC:8045]
ENSG00000111087	2.06	1.55	1.73	1.56	1.60	1.65	0.178091196889267	2.53524715371432	0.301522559133963	0.683616351877604	12:57460134-57472262:+	GLI1	48;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007418,biological_process ventral midline development;GO:0008017,molecular_function microtubule binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0009611,biological_process response to wounding;GO:0009913,biological_process epidermal cell differentiation;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009954,biological_process proximal/distal pattern formation;GO:0021696,biological_process cerebellar cortex morphogenesis;GO:0021938,biological_process smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation;GO:0021983,biological_process pituitary gland development;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0030850,biological_process prostate gland development;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045740,biological_process positive regulation of DNA replication;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048546,biological_process digestive tract morphogenesis;GO:0060032,biological_process notochord regression;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097421,biological_process liver regeneration;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:2000345,biological_process regulation of hepatocyte proliferation	GLI1; zinc finger protein GLI1; K16797	GLI family zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:4317]
ENSG00000183386	11.60	11.49	12.09	12.66	11.29	15.07	-0.13878941833307	3.40273207087155	0.301713902049528	0.683925249477865	1:37996769-38005606:-	FHL3	9;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005925,cellular_component focal adhesion;GO:0007517,biological_process muscle organ development;GO:0030018,cellular_component Z disc;GO:0030036,biological_process actin cytoskeleton organization;GO:0046872,molecular_function metal ion binding	NA	four and a half LIM domains 3 [Source:HGNC Symbol%3BAcc:HGNC:3704]
ENSG00000184436	13.64	16.60	16.51	14.54	15.38	13.27	0.121203493391477	3.80761648498586	0.301895218897972	0.684194770800737	22:20999103-21002196:-	THAP7	15;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016607,cellular_component nuclear speck;GO:0031965,cellular_component nuclear membrane;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0070742,molecular_function C2H2 zinc finger domain binding	NA	THAP domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:23190]
ENSG00000139880	7.13	7.70	6.77	6.00	7.16	7.01	0.104270009405092	4.10662319084501	0.302034199484183	0.684194770800737	14:23047061-23057538:-	CDH24	10;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0034332,biological_process adherens junction organization;GO:0046872,molecular_function metal ion binding	NA	cadherin 24 [Source:HGNC Symbol%3BAcc:HGNC:14265]
ENSG00000043355	6.33	5.09	5.03	5.21	4.80	5.02	0.149004268976852	3.09512063446522	0.302154767242142	0.684194770800737	13:99981771-99986773:+	ZIC2	18;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0007601,biological_process visual perception;GO:0016604,cellular_component nuclear body;GO:0030154,biological_process cell differentiation;GO:0031490,molecular_function chromatin DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity	NA	Zic family member 2 [Source:HGNC Symbol%3BAcc:HGNC:12873]
ENSG00000182963	22.41	22.93	19.89	23.44	23.17	23.14	-0.0889238781621653	4.74845687233555	0.302218585627447	0.684194770800737	17:44798447-44830816:-	GJC1	27;GO:0001570,biological_process vasculogenesis;GO:0005216,molecular_function ion channel activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005921,cellular_component gap junction;GO:0005922,cellular_component connexon complex;GO:0006810,biological_process transport;GO:0006936,biological_process muscle contraction;GO:0007043,biological_process cell-cell junction assembly;GO:0007154,biological_process cell communication;GO:0007267,biological_process cell-cell signaling;GO:0007268,biological_process chemical synaptic transmission;GO:0007507,biological_process heart development;GO:0007601,biological_process visual perception;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016264,biological_process gap junction assembly;GO:0030054,cellular_component cell junction;GO:0034220,biological_process ion transmembrane transport;GO:0048468,biological_process cell development;GO:0048738,biological_process cardiac muscle tissue development;GO:0086014,biological_process atrial cardiac muscle cell action potential;GO:0086020,molecular_function gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling;GO:0086021,biological_process SA node cell to atrial cardiac muscle cell communication by electrical coupling;GO:0086053,biological_process AV node cell to bundle of His cell communication by electrical coupling;GO:0086077,molecular_function gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling	NA	gap junction protein gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:4280]
ENSG00000124198	11.14	10.62	10.12	10.22	9.66	10.69	0.071972014590337	5.80532900103058	0.30224680476427	0.684194770800737	20:48921889-49036693:+	ARFGEF2	37;GO:0000139,cellular_component Golgi membrane;GO:0001881,biological_process receptor recycling;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005879,cellular_component axonemal microtubule;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0007032,biological_process endosome organization;GO:0010256,biological_process endomembrane system organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017022,molecular_function myosin binding;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0032279,cellular_component asymmetric synapse;GO:0032280,cellular_component symmetric synapse;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050811,molecular_function GABA receptor binding;GO:0055037,cellular_component recycling endosome	NA	ADP ribosylation factor guanine nucleotide exchange factor 2 [Source:HGNC Symbol%3BAcc:HGNC:15853]
ENSG00000109680	6.94	8.98	7.24	7.64	8.49	9.35	-0.138911529034174	3.72557144749028	0.302250735804216	0.684194770800737	4:26576436-26755351:+	TBC1D19	3;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0043547,biological_process positive regulation of GTPase activity	NA	TBC1 domain family member 19 [Source:HGNC Symbol%3BAcc:HGNC:25624]
ENSG00000160049	27.09	30.63	27.87	28.50	32.24	30.79	-0.0902119843203207	4.91023511627855	0.302328028964342	0.684194770800737	1:10456521-10472526:-	DFFA	20;GO:0000790,cellular_component nuclear chromatin;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0019904,molecular_function protein domain specific binding;GO:0032076,biological_process negative regulation of deoxyribonuclease activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0044183,molecular_function protein binding involved in protein folding;GO:0060703,molecular_function deoxyribonuclease inhibitor activity;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070242,biological_process thymocyte apoptotic process;GO:1900118,biological_process negative regulation of execution phase of apoptosis;GO:1902511,biological_process negative regulation of apoptotic DNA fragmentation	DFFA, DFF45; DNA fragmentation factor, 45 kD, alpha subunit; K02310	DNA fragmentation factor subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:2772]
ENSG00000204311	5.86	5.31	6.10	5.36	5.15	5.10	0.165876464228405	2.57963896941299	0.302401400930878	0.684194770800737	2:178451435-178461390:+	DFNB59	2;GO:0007605,biological_process sensory perception of sound;GO:0043025,cellular_component neuronal cell body	NA	deafness%2C autosomal recessive 59 [Source:HGNC Symbol%3BAcc:HGNC:29502]
ENSG00000161217	20.93	21.85	20.33	19.40	20.63	20.24	0.0752912911099711	5.08141754015518	0.30244675883314	0.684194770800737	3:196214221-196287957:-	PCYT1A	22;GO:0003824,molecular_function catalytic activity;GO:0004105,molecular_function choline-phosphate cytidylyltransferase activity;GO:0005516,molecular_function calmodulin binding;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006657,biological_process CDP-choline pathway;GO:0006952,biological_process defense response;GO:0008289,molecular_function lipid binding;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0031210,molecular_function phosphatidylcholine binding;GO:0042587,cellular_component glycogen granule;GO:0042803,molecular_function protein homodimerization activity	PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15]; K00968	phosphate cytidylyltransferase 1%2C choline%2C alpha [Source:HGNC Symbol%3BAcc:HGNC:8754]
ENSG00000089053	37.51	36.62	34.09	35.13	34.88	34.06	0.0677840183699838	6.43489562985087	0.302455483687775	0.684194770800737	12:121308244-121399896:-	ANAPC5	15;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0019903,molecular_function protein phosphatase binding;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC5; anaphase-promoting complex subunit 5; K03352	anaphase promoting complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:15713]
ENSG00000149476	17.68	17.48	16.90	17.51	15.16	16.86	0.0826627120332144	5.0005373060767	0.302490801108595	0.684194770800737	11:61333209-61353295:+	TKFC	23;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004371,molecular_function glycerone kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006071,biological_process glycerol metabolic process;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016829,molecular_function lyase activity;GO:0034012,molecular_function FAD-AMP lyase (cyclizing) activity;GO:0039534,biological_process negative regulation of MDA-5 signaling pathway;GO:0044262,biological_process cellular carbohydrate metabolic process;GO:0045087,biological_process innate immune response;GO:0045088,biological_process regulation of innate immune response;GO:0046835,biological_process carbohydrate phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050354,molecular_function triokinase activity;GO:0061624,biological_process fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0070062,cellular_component extracellular exosome	DAK, TKFC; triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:2.7.1.28 2.7.1.29 4.6.1.15]; K00863	triokinase and FMN cyclase [Source:HGNC Symbol%3BAcc:HGNC:24552]
ENSG00000196715	52.01	56.36	51.78	54.78	59.16	56.28	-0.0801664042526468	5.14728861355011	0.302494232027265	0.684194770800737	7:65873266-65959563:+	VKORC1L1	11;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0017187,biological_process peptidyl-glutamic acid carboxylation;GO:0034599,biological_process cellular response to oxidative stress;GO:0042373,biological_process vitamin K metabolic process;GO:0047057,molecular_function vitamin-K-epoxide reductase (warfarin-sensitive) activity;GO:0048038,molecular_function quinone binding;GO:0055114,biological_process oxidation-reduction process	NA	vitamin K epoxide reductase complex subunit 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:21492]
ENSG00000163029	25.63	23.05	24.59	25.37	25.09	27.11	-0.0686944847234114	6.42217282445795	0.302816088544534	0.684675556461259	2:17663811-17800242:-	SMC6	22;GO:0000166,molecular_function nucleotide binding;GO:0000722,biological_process telomere maintenance via recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0000803,cellular_component sex chromosome;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0030915,cellular_component Smc5-Smc6 complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035061,cellular_component interchromatin granule;GO:0035861,cellular_component site of double-strand break;GO:0051984,biological_process positive regulation of chromosome segregation;GO:0090398,biological_process cellular senescence	NA	structural maintenance of chromosomes 6 [Source:HGNC Symbol%3BAcc:HGNC:20466]
ENSG00000138078	25.45	25.69	25.73	25.71	27.79	27.66	-0.0670745481758604	5.92925093804504	0.302817111493782	0.684675556461259	2:44316280-44361862:-	PREPL	11;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0070008,molecular_function serine-type exopeptidase activity;GO:2000300,biological_process regulation of synaptic vesicle exocytosis	NA	prolyl endopeptidase-like [Source:HGNC Symbol%3BAcc:HGNC:30228]
ENSG00000107937	36.43	34.72	33.86	36.53	35.57	38.93	-0.0686509402864193	6.10239049228117	0.303164575523332	0.685336346015502	10:988018-1019936:+	GTPBP4	23;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000166,molecular_function nucleotide binding;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0008156,biological_process negative regulation of DNA replication;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030336,biological_process negative regulation of cell migration;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031965,cellular_component nuclear membrane;GO:0033342,biological_process negative regulation of collagen binding;GO:0042254,biological_process ribosome biogenesis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization	NOG1; nucleolar GTP-binding protein; K06943	GTP binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:21535]
ENSG00000125037	74.24	79.28	78.19	74.46	70.61	77.52	0.0678060951994525	6.09081261620687	0.303567293036017	0.68612177867008	3:9962536-10011116:-	EMC3	6;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:23999]
ENSG00000100302	11.59	6.95	9.13	11.35	10.55	9.78	-0.164940452264109	3.02221469239206	0.303719123682114	0.686339974925555	22:35540867-35554001:+	RASD2	17;GO:0000166,molecular_function nucleotide binding;GO:0001963,biological_process synaptic transmission, dopaminergic;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007626,biological_process locomotory behavior;GO:0016020,cellular_component membrane;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031681,molecular_function G-protein beta-subunit binding;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043949,biological_process regulation of cAMP-mediated signaling;GO:0051897,biological_process positive regulation of protein kinase B signaling	NA	RASD family member 2 [Source:HGNC Symbol%3BAcc:HGNC:18229]
ENSG00000101182	174.40	180.84	158.88	178.27	181.95	183.13	-0.0691170965881749	7.28224586540116	0.303904242937357	0.686536899063347	20:62136734-62143440:-	PSMA7	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019773,cellular_component proteasome core complex, alpha-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0098794,cellular_component postsynapse;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]; K02731	proteasome subunit alpha 7 [Source:HGNC Symbol%3BAcc:HGNC:9536]
ENSG00000010295	10.15	11.37	12.03	9.55	10.60	11.25	0.103978240098737	4.23946763058675	0.303932823929098	0.686536899063347	12:6538374-6556083:-	IFFO1	2;GO:0005198,molecular_function structural molecule activity;GO:0005882,cellular_component intermediate filament	NA	intermediate filament family orphan 1 [Source:HGNC Symbol%3BAcc:HGNC:24970]
ENSG00000164038	0.83	0.98	1.33	1.13	1.26	1.40	-0.263689057091825	1.34051241253466	0.304149707176706	0.686536899063347	4:103019867-103085829:-	SLC9B2	38;GO:0005451,molecular_function monovalent cation:proton antiporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0010008,cellular_component endosome membrane;GO:0010348,molecular_function lithium:proton antiporter activity;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030054,cellular_component cell junction;GO:0030317,biological_process sperm motility;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031966,cellular_component mitochondrial membrane;GO:0034220,biological_process ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0055085,biological_process transmembrane transport;GO:0055114,biological_process oxidation-reduction process;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0097228,cellular_component sperm principal piece;GO:0097708,cellular_component intracellular vesicle;GO:1902600,biological_process hydrogen ion transmembrane transport;GO:2001206,biological_process positive regulation of osteoclast development	NA	solute carrier family 9 member B2 [Source:HGNC Symbol%3BAcc:HGNC:25143]
ENSG00000198176	27.69	34.60	26.58	27.65	27.27	28.54	0.0945484336815224	5.14689548924824	0.304190651472139	0.686536899063347	13:113584720-113641470:+	TFDP1	31;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0008544,biological_process epidermis development;GO:0019904,molecular_function protein domain specific binding;GO:0043276,biological_process anoikis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070345,biological_process negative regulation of fat cell proliferation;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:2000278,biological_process regulation of DNA biosynthetic process	TFDP1; transcription factor Dp-1; K04683	transcription factor Dp-1 [Source:HGNC Symbol%3BAcc:HGNC:11749]
ENSG00000142444	10.32	9.43	10.85	8.54	9.04	10.37	0.14669327170039	2.96079274270217	0.304220430140273	0.686536899063347	19:10928732-10933535:+	TIMM29	9;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042721,cellular_component mitochondrial inner membrane protein insertion complex	NA	translocase of inner mitochondrial membrane 29 [Source:HGNC Symbol%3BAcc:HGNC:25152]
ENSG00000140464	20.02	19.01	19.95	21.56	20.32	20.41	-0.0653190727746948	6.29238570611737	0.30422165568256	0.686536899063347	15:73994672-74047812:+	PML	86;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000792,cellular_component heterochromatin;GO:0001666,biological_process response to hypoxia;GO:0001932,biological_process regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006461,biological_process protein complex assembly;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007050,biological_process cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007182,biological_process common-partner SMAD protein phosphorylation;GO:0007184,biological_process SMAD protein import into nucleus;GO:0007569,biological_process cell aging;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0009411,biological_process response to UV;GO:0010332,biological_process response to gamma radiation;GO:0010522,biological_process regulation of calcium ion transport into cytosol;GO:0010761,biological_process fibroblast migration;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016363,cellular_component nuclear matrix;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016605,cellular_component PML body;GO:0030099,biological_process myeloid cell differentiation;GO:0030155,biological_process regulation of cell adhesion;GO:0030308,biological_process negative regulation of cell growth;GO:0030578,biological_process PML body organization;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031901,cellular_component early endosome membrane;GO:0032183,molecular_function SUMO binding;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0032922,biological_process circadian regulation of gene expression;GO:0034097,biological_process response to cytokine;GO:0042406,cellular_component extrinsic component of endoplasmic reticulum membrane;GO:0042752,biological_process regulation of circadian rhythm;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042803,molecular_function protein homodimerization activity;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045087,biological_process innate immune response;GO:0045165,biological_process cell fate commitment;GO:0045343,biological_process regulation of MHC class I biosynthetic process;GO:0045345,biological_process positive regulation of MHC class I biosynthetic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0048511,biological_process rhythmic process;GO:0050711,biological_process negative regulation of interleukin-1 secretion;GO:0050713,biological_process negative regulation of interleukin-1 beta secretion;GO:0051457,biological_process maintenance of protein location in nucleus;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071353,biological_process cellular response to interleukin-4;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0090398,biological_process cellular senescence;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902187,biological_process negative regulation of viral release from host cell;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000779,biological_process regulation of double-strand break repair;GO:2001235,biological_process positive regulation of apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	PML, TRIM19; probable transcription factor PML; K10054	promyelocytic leukemia [Source:HGNC Symbol%3BAcc:HGNC:9113]
ENSG00000114850	142.06	150.42	132.31	134.84	141.46	130.69	0.0717430985702985	6.39953147648105	0.304384444248984	0.686536899063347	3:156540139-156555184:-	SSR3	6;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	SSR3; translocon-associated protein subunit gamma; K13251	signal sequence receptor subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:11325]
ENSG00000108468	125.58	128.88	125.95	133.66	142.87	126.15	-0.0705732100685746	6.21566536942725	0.30438688760512	0.686536899063347	17:48070051-48101521:-	CBX1	18;GO:0000775,cellular_component chromosome, centromeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0001939,cellular_component female pronucleus;GO:0001940,cellular_component male pronucleus;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005720,cellular_component nuclear heterochromatin;GO:0005721,cellular_component pericentric heterochromatin;GO:0005819,cellular_component spindle;GO:0010369,cellular_component chromocenter;GO:0019899,molecular_function enzyme binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:1990226,molecular_function histone methyltransferase binding	NA	chromobox 1 [Source:HGNC Symbol%3BAcc:HGNC:1551]
ENSG00000151575	3.39	3.71	3.25	4.17	3.99	3.59	-0.175068448053203	2.316115437096	0.30451915982619	0.686536899063347	15:56244008-56445997:+	TEX9	1;GO:0005515,molecular_function protein binding	NA	testis expressed 9 [Source:HGNC Symbol%3BAcc:HGNC:29585]
ENSG00000149716	201.22	153.61	204.01	234.81	155.50	230.28	-0.138726938478243	7.3278641332169	0.304603397333002	0.686536899063347	11:69653075-69675416:-	ORAOV1	10;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0006289,biological_process nucleotide-excision repair;GO:0008150,biological_process biological_process;GO:0030896,cellular_component checkpoint clamp complex;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0033314,biological_process mitotic DNA replication checkpoint;GO:0035861,cellular_component site of double-strand break;GO:0044778,biological_process meiotic DNA integrity checkpoint	NA	oral cancer overexpressed 1 [Source:HGNC Symbol%3BAcc:HGNC:17589]
ENSG00000145675	10.30	10.56	10.61	9.22	10.52	10.11	0.0873226515479164	4.60816326071458	0.304634549375065	0.686536899063347	5:68215719-68301821:+	PIK3R1	80;GO:0001678,biological_process cellular glucose homeostasis;GO:0001784,molecular_function phosphotyrosine binding;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005168,molecular_function neurotrophin TRKA receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005801,cellular_component cis-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005942,cellular_component phosphatidylinositol 3-kinase complex;GO:0005943,cellular_component phosphatidylinositol 3-kinase complex, class IA;GO:0006468,biological_process protein phosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0008134,molecular_function transcription factor binding;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0019903,molecular_function protein phosphatase binding;GO:0030168,biological_process platelet activation;GO:0030183,biological_process B cell differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0031295,biological_process T cell costimulation;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033120,biological_process positive regulation of RNA splicing;GO:0034644,biological_process cellular response to UV;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035014,molecular_function phosphatidylinositol 3-kinase regulator activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0036312,molecular_function phosphatidylinositol 3-kinase regulatory subunit binding;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043125,molecular_function ErbB-3 class receptor binding;GO:0043234,cellular_component protein complex;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043551,biological_process regulation of phosphatidylinositol 3-kinase activity;GO:0043559,molecular_function insulin binding;GO:0043560,molecular_function insulin receptor substrate binding;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046326,biological_process positive regulation of glucose import;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0046935,molecular_function 1-phosphatidylinositol-3-kinase regulator activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050821,biological_process protein stabilization;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051531,biological_process NFAT protein import into nucleus;GO:0060396,biological_process growth hormone receptor signaling pathway;GO:0090003,biological_process regulation of establishment of protein localization to plasma membrane;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:1900103,biological_process positive regulation of endoplasmic reticulum unfolded protein response;GO:1990578,cellular_component perinuclear endoplasmic reticulum membrane;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta; K02649	phosphoinositide-3-kinase regulatory subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:8979]
ENSG00000144810	49.27	64.14	50.39	56.19	70.37	52.49	-0.118105806519339	6.99552322764483	0.304695871823368	0.686536899063347	3:99638474-99799226:+	COL8A1	18;GO:0001525,biological_process angiogenesis;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005591,cellular_component collagen type VIII trimer;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035987,biological_process endodermal cell differentiation;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050673,biological_process epithelial cell proliferation;GO:0070062,cellular_component extracellular exosome	NA	collagen type VIII alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2215]
ENSG00000159069	48.71	45.70	48.72	46.46	44.18	47.22	0.0672350343994731	6.37158563444138	0.304709824784958	0.686536899063347	9:136940434-136944696:-	FBXW5	14;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0010824,biological_process regulation of centrosome duplication;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019901,molecular_function protein kinase binding;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	F-box and WD repeat domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:13613]
ENSG00000122741	13.32	12.61	13.84	11.16	13.45	12.89	0.0994550649615586	4.46155326286182	0.304761814059093	0.686536899063347	9:37800501-37867666:+	DCAF10	4;GO:0005654,cellular_component nucleoplasm;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 10 [Source:HGNC Symbol%3BAcc:HGNC:23686]
ENSG00000126562	1.48	1.20	1.93	2.29	1.34	1.81	-0.215320939249043	2.69174474712297	0.304813472319817	0.686536899063347	17:42780677-42796936:+	WNK4	26;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005923,cellular_component bicellular tight junction;GO:0006468,biological_process protein phosphorylation;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0008104,biological_process protein localization;GO:0010766,biological_process negative regulation of sodium ion transport;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019869,molecular_function chloride channel inhibitor activity;GO:0030054,cellular_component cell junction;GO:0035556,biological_process intracellular signal transduction;GO:0050794,biological_process regulation of cellular process;GO:0050801,biological_process ion homeostasis;GO:0065009,biological_process regulation of molecular function;GO:0070294,biological_process renal sodium ion absorption;GO:0072156,biological_process distal tubule morphogenesis;GO:0090188,biological_process negative regulation of pancreatic juice secretion	NA	WNK lysine deficient protein kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:14544]
ENSG00000183426	8.89	9.32	11.96	10.56	8.23	8.80	0.143083808463704	3.81636611586031	0.304837578155459	0.686536899063347	16:14922801-14952060:+	NPIPA1	9;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0051028,biological_process mRNA transport	NA	nuclear pore complex interacting protein family member A1 [Source:HGNC Symbol%3BAcc:HGNC:7909]
ENSG00000035141	27.01	29.15	31.62	28.63	29.08	25.08	0.0969461734072584	4.73359716799727	0.304907736729999	0.686536899063347	2:70295974-70302090:-	FAM136A	1;GO:0005737,cellular_component cytoplasm	NA	family with sequence similarity 136 member A [Source:HGNC Symbol%3BAcc:HGNC:25911]
ENSG00000140350	169.99	167.24	176.66	186.58	179.22	176.17	-0.0643546722702991	7.05093463594758	0.304948021297124	0.686536899063347	15:68778534-68820897:-	ANP32A	14;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006913,biological_process nucleocytoplasmic transport;GO:0035556,biological_process intracellular signal transduction;GO:0042393,molecular_function histone binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043488,biological_process regulation of mRNA stability;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	acidic nuclear phosphoprotein 32 family member A [Source:HGNC Symbol%3BAcc:HGNC:13233]
ENSG00000130734	6.83	7.62	7.92	5.88	7.10	7.61	0.126812941071548	3.58377928699406	0.304972669168019	0.686536899063347	19:10543894-10553418:+	ATG4D	19;GO:0000045,biological_process autophagosome assembly;GO:0000422,biological_process mitophagy;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006501,biological_process C-terminal protein lipidation;GO:0006508,biological_process proteolysis;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0015031,biological_process protein transport;GO:0016787,molecular_function hydrolase activity;GO:0044804,biological_process nucleophagy;GO:0051697,biological_process protein delipidation	ATG4; cysteine protease ATG4 [EC:3.4.22.-]; K08342	autophagy related 4D cysteine peptidase [Source:HGNC Symbol%3BAcc:HGNC:20789]
ENSG00000177663	13.76	13.68	13.68	12.88	13.78	12.69	0.0758624083798684	5.12942992679478	0.304978026042668	0.686536899063347	22:17084953-17115694:+	IL17RA	20;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030368,molecular_function interleukin-17 receptor activity;GO:0032747,biological_process positive regulation of interleukin-23 production;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050832,biological_process defense response to fungus;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071621,biological_process granulocyte chemotaxis;GO:0072537,biological_process fibroblast activation;GO:0097398,biological_process cellular response to interleukin-17;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response;GO:2000664,biological_process positive regulation of interleukin-5 secretion;GO:2000667,biological_process positive regulation of interleukin-13 secretion	IL17RA, CD217; interleukin 17 receptor A; K05164	interleukin 17 receptor A [Source:HGNC Symbol%3BAcc:HGNC:5985]
ENSG00000107130	55.04	62.78	49.36	53.18	55.57	48.25	0.0970406587243851	4.97283771695578	0.305008454133792	0.686536899063347	9:130172577-130237304:+	NCS1	26;GO:0000287,molecular_function magnesium ion binding;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0010975,biological_process regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031045,cellular_component dense core granule;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045921,biological_process positive regulation of exocytosis;GO:0046872,molecular_function metal ion binding;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport	NA	neuronal calcium sensor 1 [Source:HGNC Symbol%3BAcc:HGNC:3953]
ENSG00000131650	1.95	1.72	1.70	1.30	1.75	1.53	0.244303393348351	1.45219096217483	0.305029777696928	0.686536899063347	16:2963943-2968383:+	KREMEN2	9;GO:0005886,cellular_component plasma membrane;GO:0007154,biological_process cell communication;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030279,biological_process negative regulation of ossification;GO:0031901,cellular_component early endosome membrane;GO:0060173,biological_process limb development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	kringle containing transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18797]
ENSG00000167799	1.66	3.04	1.02	1.97	2.73	2.63	-0.396759424656439	0.764510165469177	0.3050783481216	0.686536899063347	11:67627937-67629930:-	NUDT8	2;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	nudix hydrolase 8 [Source:HGNC Symbol%3BAcc:HGNC:8055]
ENSG00000118777	0.47	0.68	0.59	0.53	0.97	0.70	-0.342985931417515	0.616439841006744	0.30515838156041	0.686592530416779	4:88090263-88231322:-	ABCG2	27;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008559,molecular_function xenobiotic-transporting ATPase activity;GO:0015232,molecular_function heme transporter activity;GO:0015886,biological_process heme transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016887,molecular_function ATPase activity;GO:0017127,molecular_function cholesterol transporter activity;GO:0031966,cellular_component mitochondrial membrane;GO:0033344,biological_process cholesterol efflux;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042803,molecular_function protein homodimerization activity;GO:0042908,biological_process xenobiotic transport;GO:0043235,cellular_component receptor complex;GO:0046415,biological_process urate metabolic process;GO:0055085,biological_process transmembrane transport	ABCG2, CD338; ATP-binding cassette, subfamily G (WHITE), member 2; K05681	ATP binding cassette subfamily G member 2 (Junior blood group) [Source:HGNC Symbol%3BAcc:HGNC:74]
ENSG00000108590	27.50	23.10	21.91	25.34	29.91	25.41	-0.135564672462553	3.35245314824658	0.305348041280294	0.686769025507513	17:6643314-6651634:-	MED31	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0060173,biological_process limb development;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070847,cellular_component core mediator complex	NA	mediator complex subunit 31 [Source:HGNC Symbol%3BAcc:HGNC:24260]
ENSG00000138688	12.28	12.41	11.98	11.45	12.03	11.94	0.0613163505451534	7.53121328380389	0.305390349988963	0.686769025507513	4:122152332-122362758:+	KIAA1109	6;GO:0001558,biological_process regulation of cell growth;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030856,biological_process regulation of epithelial cell differentiation	NA	KIAA1109 [Source:HGNC Symbol%3BAcc:HGNC:26953]
ENSG00000196177	9.54	11.95	10.73	9.71	10.65	9.44	0.115686713464256	3.75351877373827	0.305402805188228	0.686769025507513	10:123008978-123058311:+	ACADSB	12;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	ACADSB; short/branched chain acyl-CoA dehydrogenase [EC:1.3.99.12]; K09478	acyl-CoA dehydrogenase%2C short/branched chain [Source:HGNC Symbol%3BAcc:HGNC:91]
ENSG00000168066	87.28	82.56	87.56	96.26	89.14	86.53	-0.0669157678423211	7.75628829536258	0.305491324354799	0.686843653181691	11:64764605-64778786:-	SF1	26;GO:0000245,biological_process spliceosomal complex assembly;GO:0000389,biological_process mRNA 3'-splice site recognition;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005840,cellular_component ribosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0030238,biological_process male sex determination;GO:0030575,biological_process nuclear body organization;GO:0033327,biological_process Leydig cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0045131,molecular_function pre-mRNA branch point binding;GO:0046872,molecular_function metal ion binding;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050810,biological_process regulation of steroid biosynthetic process;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	splicing factor 1 [Source:HGNC Symbol%3BAcc:HGNC:12950]
ENSG00000135749	7.79	6.24	7.13	8.69	6.66	7.59	-0.10105442237092	5.63463922698134	0.30555104574674	0.686853518807369	1:232983434-233295713:-	PCNX2	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	pecanex homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:8736]
ENSG00000137275	17.40	17.95	17.62	18.34	19.48	18.37	-0.0743698206086703	5.20136933319447	0.305644478756921	0.686937056211333	6:3063990-3115187:+	RIPK1	79;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007257,biological_process activation of JUN kinase activity;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0010940,biological_process positive regulation of necrotic cell death;GO:0010942,biological_process positive regulation of cell death;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0031264,cellular_component death-inducing signaling complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034612,biological_process response to tumor necrosis factor;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0036289,biological_process peptidyl-serine autophosphorylation;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043068,biological_process positive regulation of programmed cell death;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043235,cellular_component receptor complex;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0044257,biological_process cellular protein catabolic process;GO:0045121,cellular_component membrane raft;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization;GO:0060544,biological_process regulation of necroptotic process;GO:0060545,biological_process positive regulation of necroptotic process;GO:0070231,biological_process T cell apoptotic process;GO:0070266,biological_process necroptotic process;GO:0070513,molecular_function death domain binding;GO:0070926,biological_process regulation of ATP:ADP antiporter activity;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071550,biological_process death-inducing signaling complex assembly;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097342,cellular_component ripoptosome;GO:0097343,biological_process ripoptosome assembly;GO:0097527,biological_process necroptotic signaling pathway;GO:1901026,biological_process ripoptosome assembly involved in necroptotic process;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1905206,biological_process positive regulation of hydrogen peroxide-induced cell death;GO:1990000,biological_process amyloid fibril formation;GO:2000377,biological_process regulation of reactive oxygen species metabolic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]; K02861	receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:10019]
ENSG00000171566	26.84	27.31	28.76	28.99	29.36	29.34	-0.0686784114138215	5.59840892390198	0.305698888142383	0.686937056211333	4:154535005-154550435:-	PLRG1	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0031965,cellular_component nuclear membrane;GO:0034504,biological_process protein localization to nucleus;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle	PLRG1, PRL1, PRP46; pleiotropic regulator 1; K12862	pleiotropic regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:9089]
ENSG00000164050	10.67	11.03	10.72	10.05	10.72	10.45	0.0650757597247769	6.08963015770927	0.305903348312341	0.687174039551247	3:48403853-48430051:-	PLXNB1	30;GO:0002116,cellular_component semaphorin receptor complex;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0017154,molecular_function semaphorin receptor activity;GO:0030215,molecular_function semaphorin receptor binding;GO:0032794,molecular_function GTPase activating protein binding;GO:0033689,biological_process negative regulation of osteoblast proliferation;GO:0035556,biological_process intracellular signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043931,biological_process ossification involved in bone maturation;GO:0048675,biological_process axon extension;GO:0048812,biological_process neuron projection morphogenesis;GO:0050772,biological_process positive regulation of axonogenesis;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:1900220,biological_process semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis	PLXNB; plexin B; K06821	plexin B1 [Source:HGNC Symbol%3BAcc:HGNC:9103]
ENSG00000088876	5.56	4.27	5.19	5.24	4.12	4.35	0.153847019482335	3.26733712802557	0.306023252046517	0.687174039551247	20:2481816-2524702:-	ZNF343	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 343 [Source:HGNC Symbol%3BAcc:HGNC:16017]
ENSG00000101138	27.79	27.84	24.50	28.83	26.35	30.43	-0.0867747661101406	5.17445200132502	0.306045351432593	0.687174039551247	20:56392370-56406369:+	CSTF1	8;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0031124,biological_process mRNA 3'-end processing	CSTF1; cleavage stimulation factor subunit 1; K14406	cleavage stimulation factor subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:2483]
ENSG00000132485	85.71	89.48	99.34	85.51	89.96	87.60	0.0737146365372944	6.51869179458759	0.306122351154302	0.687174039551247	1:71063290-71081297:-	ZRANB2	9;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0046872,molecular_function metal ion binding	NA	zinc finger RANBP2-type containing 2 [Source:HGNC Symbol%3BAcc:HGNC:13058]
ENSG00000164855	5.72	4.13	4.60	5.54	5.38	5.42	-0.151606836103726	2.77706393862889	0.306171756652799	0.687174039551247	7:1542234-1560821:-	TMEM184A	14;GO:0005215,molecular_function transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008201,molecular_function heparin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030658,cellular_component transport vesicle membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	transmembrane protein 184A [Source:HGNC Symbol%3BAcc:HGNC:28797]
ENSG00000119138	13.51	14.49	15.18	16.06	14.40	16.91	-0.125001425792078	3.48768636054251	0.306200422570962	0.687174039551247	9:70384596-70414624:-	KLF9	16;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007623,biological_process circadian rhythm;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0071387,biological_process cellular response to cortisol stimulus;GO:0097067,biological_process cellular response to thyroid hormone stimulus	NA	Kruppel like factor 9 [Source:HGNC Symbol%3BAcc:HGNC:1123]
ENSG00000113716	20.07	19.97	19.33	20.98	20.25	21.38	-0.0655840771542818	6.55494709700445	0.306236755271178	0.687174039551247	5:150000045-150053142:+	HMGXB3	6;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation	NA	HMG-box containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28982]
ENSG00000079150	36.88	38.14	39.86	36.99	37.36	34.85	0.085567243623332	4.6622206787918	0.306247223620196	0.687174039551247	2:178463663-178478600:-	FKBP7	11;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005528,molecular_function FK506 binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0016853,molecular_function isomerase activity;GO:0046872,molecular_function metal ion binding;GO:0061077,biological_process chaperone-mediated protein folding	NA	FK506 binding protein 7 [Source:HGNC Symbol%3BAcc:HGNC:3723]
ENSG00000159792	9.36	11.34	11.30	8.99	10.54	10.13	0.114613303437409	3.8315252006559	0.306313958391102	0.687199560005196	16:67893271-67929678:+	PSKH1	27;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0035556,biological_process intracellular signal transduction	NA	protein serine kinase H1 [Source:HGNC Symbol%3BAcc:HGNC:9529]
ENSG00000061337	0.87	1.02	0.62	0.96	1.23	0.94	-0.331104457056309	0.867591814288418	0.306418571685956	0.687310034394248	8:20246164-20303963:-	LZTS1	24;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0044297,cellular_component cell body;GO:0044772,biological_process mitotic cell cycle phase transition;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048814,biological_process regulation of dendrite morphogenesis	NA	leucine zipper tumor suppressor 1 [Source:HGNC Symbol%3BAcc:HGNC:13861]
ENSG00000174611	1.46	1.20	1.82	1.32	1.30	1.24	0.244465206724871	1.54843222089395	0.306511997708345	0.687339399779375	3:134603137-134651636:-	KY	6;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0030018,cellular_component Z disc	NA	kyphoscoliosis peptidase [Source:HGNC Symbol%3BAcc:HGNC:26576]
ENSG00000100344	1.86	2.52	1.58	1.45	1.73	1.80	0.239633147955405	1.46047023722639	0.306542408537712	0.687339399779375	22:43923738-43964488:+	PNPLA3	29;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0004465,molecular_function lipoprotein lipase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0004806,molecular_function triglyceride lipase activity;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0006629,biological_process lipid metabolic process;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016411,molecular_function acylglycerol O-acyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016787,molecular_function hydrolase activity;GO:0019432,biological_process triglyceride biosynthetic process;GO:0019433,biological_process triglyceride catabolic process;GO:0034389,biological_process lipid particle organization;GO:0035727,molecular_function lysophosphatidic acid binding;GO:0036042,molecular_function long-chain fatty acyl-CoA binding;GO:0036153,biological_process triglyceride acyl-chain remodeling;GO:0036155,biological_process acylglycerol acyl-chain remodeling;GO:0042171,molecular_function lysophosphatidic acid acyltransferase activity;GO:0051264,molecular_function mono-olein transacylation activity;GO:0051265,molecular_function diolein transacylation activity;GO:0055088,biological_process lipid homeostasis	PNPLA3; patatin-like phospholipase domain-containing protein 3 [EC:3.1.1.3 2.3.1.-]; K13534	patatin like phospholipase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:18590]
ENSG00000124151	18.52	16.64	17.95	18.73	17.95	19.53	-0.0679650830806834	6.29733400342181	0.306745996237912	0.687429304468575	20:47501901-47656877:+	NCOA3	34;GO:0000790,cellular_component nuclear chromatin;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010628,biological_process positive regulation of gene expression;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032870,biological_process cellular response to hormone stimulus;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035624,biological_process receptor transactivation;GO:0043234,cellular_component protein complex;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0050681,molecular_function androgen receptor binding;GO:0070062,cellular_component extracellular exosome;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0097718,molecular_function disordered domain specific binding;GO:2001141,biological_process regulation of RNA biosynthetic process	NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3 [EC:2.3.1.48]; K11256	nuclear receptor coactivator 3 [Source:HGNC Symbol%3BAcc:HGNC:7670]
ENSG00000170631	6.83	7.29	6.08	7.17	7.64	7.11	-0.112348686962994	3.85821533491066	0.306771999252791	0.687429304468575	8:144930357-144950888:-	ZNF16	19;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0033674,biological_process positive regulation of kinase activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045654,biological_process positive regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0051781,biological_process positive regulation of cell division;GO:0072707,biological_process cellular response to sodium dodecyl sulfate;GO:1901989,biological_process positive regulation of cell cycle phase transition	NA	zinc finger protein 16 [Source:HGNC Symbol%3BAcc:HGNC:12947]
ENSG00000070756	1152.27	1150.84	1183.21	1239.97	1178.06	1240.84	-0.0578663101396318	11.1523191742672	0.306776478417606	0.687429304468575	8:100685815-100722809:-	PABPC1	34;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0006413,biological_process translational initiation;GO:0008022,molecular_function protein C-terminus binding;GO:0008143,molecular_function poly(A) binding;GO:0008266,molecular_function poly(U) RNA binding;GO:0008380,biological_process RNA splicing;GO:0008494,molecular_function translation activator activity;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031047,biological_process gene silencing by RNA;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0043488,biological_process regulation of mRNA stability;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045727,biological_process positive regulation of translation;GO:0048255,biological_process mRNA stabilization;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:2000623,biological_process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	PABPC; polyadenylate-binding protein; K13126	poly(A) binding protein cytoplasmic 1 [Source:HGNC Symbol%3BAcc:HGNC:8554]
ENSG00000137054	16.52	15.24	15.42	17.14	14.94	18.82	-0.0971453229012682	4.72003259315138	0.306905979678572	0.687429304468575	9:37485934-37503697:+	POLR1E	16;GO:0001054,molecular_function RNA polymerase I activity;GO:0001179,molecular_function RNA polymerase I transcription factor binding;GO:0001189,biological_process RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0009303,biological_process rRNA transcription;GO:0045815,biological_process positive regulation of gene expression, epigenetic	RPA49, POLR1E; DNA-directed RNA polymerase I subunit RPA49; K03005	RNA polymerase I subunit E [Source:HGNC Symbol%3BAcc:HGNC:17631]
ENSG00000169220	10.84	15.00	14.32	11.31	13.51	12.24	0.121756486030575	4.4567193896812	0.306914443682427	0.687429304468575	5:177357836-177372601:+	RGS14	54;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005057,molecular_function receptor signaling protein activity;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006979,biological_process response to oxidative stress;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007059,biological_process chromosome segregation;GO:0007165,biological_process signal transduction;GO:0007612,biological_process learning;GO:0007616,biological_process long-term memory;GO:0008017,molecular_function microtubule binding;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0008542,biological_process visual learning;GO:0009968,biological_process negative regulation of signal transduction;GO:0010070,biological_process zygote asymmetric cell division;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030425,cellular_component dendrite;GO:0030695,molecular_function GTPase regulator activity;GO:0031914,biological_process negative regulation of synaptic plasticity;GO:0032794,molecular_function GTPase activating protein binding;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043620,biological_process regulation of DNA-templated transcription in response to stress;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0050769,biological_process positive regulation of neurogenesis;GO:0050790,biological_process regulation of catalytic activity;GO:0051301,biological_process cell division;GO:0060291,biological_process long-term synaptic potentiation;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	NA	regulator of G protein signaling 14 [Source:HGNC Symbol%3BAcc:HGNC:9996]
ENSG00000175826	95.62	100.79	98.74	95.64	92.83	95.87	0.0639408236782417	6.14692086892356	0.306966192606402	0.687429304468575	17:7243590-7252491:-	CTDNEP1	23;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006998,biological_process nuclear envelope organization;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007276,biological_process gamete generation;GO:0007498,biological_process mesoderm development;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0031965,cellular_component nuclear membrane;GO:0034504,biological_process protein localization to nucleus;GO:0071595,cellular_component Nem1-Spo7 phosphatase complex;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	CTD nuclear envelope phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:19085]
ENSG00000139291	12.22	16.45	9.80	11.63	12.58	10.17	0.16371068804389	3.77617799464192	0.306970163108782	0.687429304468575	12:71686086-71705046:+	TMEM19	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 19 [Source:HGNC Symbol%3BAcc:HGNC:25605]
ENSG00000143303	19.73	14.15	18.80	17.76	15.43	15.89	0.122499514882152	4.61069586482566	0.307093274007913	0.687580954231643	1:156728441-156736960:+	RRNAD1	7;GO:0000154,biological_process rRNA modification;GO:0000179,molecular_function rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0008649,molecular_function rRNA methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation	NA	ribosomal RNA adenine dimethylase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24273]
ENSG00000094841	18.92	17.83	18.45	19.63	20.39	19.31	-0.0886404490507172	4.33181923841212	0.307160298043081	0.687606993617452	X:75274084-75304600:+	UPRT	14;GO:0000166,molecular_function nucleotide binding;GO:0004849,molecular_function uridine kinase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006206,biological_process pyrimidine nucleobase metabolic process;GO:0006222,biological_process UMP biosynthetic process;GO:0007565,biological_process female pregnancy;GO:0007595,biological_process lactation;GO:0009116,biological_process nucleoside metabolic process;GO:0032868,biological_process response to insulin;GO:0043097,biological_process pyrimidine nucleoside salvage	upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]; K00761	uracil phosphoribosyltransferase homolog [Source:HGNC Symbol%3BAcc:HGNC:28334]
ENSG00000164088	9.53	7.40	8.67	10.00	8.10	10.21	-0.125497945494516	3.73899117056248	0.307338445162531	0.687841367067288	3:52245792-52250597:+	PPM1M	9;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0006470,biological_process protein dephosphorylation;GO:0008420,molecular_function CTD phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0046872,molecular_function metal ion binding	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1M [Source:HGNC Symbol%3BAcc:HGNC:26506]
ENSG00000213380	2.06	1.80	2.10	2.39	2.34	2.17	-0.187893995420759	1.97254753839598	0.307478360429428	0.687841367067288	16:69320139-69339583:-	COG8	1;GO:0017119,cellular_component Golgi transport complex	NA	NA
ENSG00000135945	12.43	13.63	12.58	13.39	13.85	13.60	-0.0720557596166237	5.69442338569365	0.307484591820698	0.687841367067288	2:99400474-99490035:-	REV1	16;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0017125,molecular_function deoxycytidyl transferase activity;GO:0019985,biological_process translesion synthesis;GO:0042276,biological_process error-prone translesion synthesis;GO:0046872,molecular_function metal ion binding;GO:0071897,biological_process DNA biosynthetic process	REV1; DNA repair protein REV1 [EC:2.7.7.-]; K03515	REV1%2C DNA directed polymerase [Source:HGNC Symbol%3BAcc:HGNC:14060]
ENSG00000089048	19.59	21.15	19.81	21.56	21.66	20.77	-0.0706914495041905	5.7316728228248	0.30748664672975	0.687841367067288	20:13714321-13784886:-	ESF1	7;GO:0003723,molecular_function RNA binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	ESF1 nucleolar pre-rRNA processing protein homolog [Source:HGNC Symbol%3BAcc:HGNC:15898]
ENSG00000172404	1.90	1.96	1.03	2.67	1.55	1.90	-0.322979893806153	0.88724625236936	0.307616219908764	0.68800723202297	22:40859548-40862126:-	DNAJB7	1;GO:0051087,molecular_function chaperone binding	NA	DnaJ heat shock protein family (Hsp40) member B7 [Source:HGNC Symbol%3BAcc:HGNC:24986]
ENSG00000185989	14.17	10.24	12.91	13.32	9.88	11.35	0.128352760448877	4.91863312328337	0.30781259080003	0.688322408503111	13:113977782-114132611:-	RASA3	15;GO:0000165,biological_process MAPK cascade;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0035556,biological_process intracellular signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding;GO:0051209,biological_process release of sequestered calcium ion into cytosol	RASA3; Ras GTPase-activating protein 3; K12380	RAS p21 protein activator 3 [Source:HGNC Symbol%3BAcc:HGNC:20331]
ENSG00000072364	21.79	21.66	23.33	23.65	24.02	22.87	-0.0659899386703868	6.34913505856263	0.307907365292589	0.688410325175957	5:132875378-132963634:-	AFF4	12;GO:0001650,cellular_component fibrillar center;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0007286,biological_process spermatid development;GO:0008023,cellular_component transcription elongation factor complex;GO:0035327,cellular_component transcriptionally active chromatin	NA	AF4/FMR2 family member 4 [Source:HGNC Symbol%3BAcc:HGNC:17869]
ENSG00000102081	27.88	32.31	33.05	33.01	33.00	33.03	-0.0772816499697977	6.06380084424758	0.308091158859455	0.688585907309328	X:147911950-147951125:+	FMR1	104;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000775,cellular_component chromosome, centromeric region;GO:0002092,biological_process positive regulation of receptor internalization;GO:0002151,molecular_function G-quadruplex RNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0005845,cellular_component mRNA cap binding complex;GO:0005886,cellular_component plasma membrane;GO:0006397,biological_process mRNA processing;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007215,biological_process glutamate receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0008017,molecular_function microtubule binding;GO:0008266,molecular_function poly(U) RNA binding;GO:0008380,biological_process RNA splicing;GO:0010369,cellular_component chromocenter;GO:0014069,cellular_component postsynaptic density;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019034,cellular_component viral replication complex;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0030054,cellular_component cell junction;GO:0030371,molecular_function translation repressor activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031047,biological_process gene silencing by RNA;GO:0031369,molecular_function translation initiation factor binding;GO:0032433,cellular_component filopodium tip;GO:0032797,cellular_component SMN complex;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0033592,molecular_function RNA strand annealing activity;GO:0034046,molecular_function poly(G) binding;GO:0034644,biological_process cellular response to UV;GO:0035064,molecular_function methylated histone binding;GO:0035197,molecular_function siRNA binding;GO:0035198,molecular_function miRNA binding;GO:0035613,molecular_function RNA stem-loop binding;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0042734,cellular_component presynaptic membrane;GO:0042788,cellular_component polysomal ribosome;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043022,molecular_function ribosome binding;GO:0043197,cellular_component dendritic spine;GO:0043204,cellular_component perikaryon;GO:0043488,biological_process regulation of mRNA stability;GO:0043679,cellular_component axon terminus;GO:0044325,molecular_function ion channel binding;GO:0044830,biological_process modulation by host of viral RNA genome replication;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045727,biological_process positive regulation of translation;GO:0045947,biological_process negative regulation of translational initiation;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0046982,molecular_function protein heterodimerization activity;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051028,biological_process mRNA transport;GO:0051489,biological_process regulation of filopodium assembly;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0060998,biological_process regulation of dendritic spine development;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0070840,molecular_function dynein complex binding;GO:0071598,cellular_component neuronal ribonucleoprotein granule;GO:0072711,biological_process cellular response to hydroxyurea;GO:0097386,cellular_component glial cell projection;GO:0098586,biological_process cellular response to virus;GO:0098793,cellular_component presynapse;GO:0098794,cellular_component postsynapse;GO:0098908,biological_process regulation of neuronal action potential;GO:1900453,biological_process negative regulation of long term synaptic depression;GO:1901254,biological_process positive regulation of intracellular transport of viral material;GO:1901386,biological_process negative regulation of voltage-gated calcium channel activity;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902373,biological_process negative regulation of mRNA catabolic process;GO:1902416,biological_process positive regulation of mRNA binding;GO:1902737,cellular_component dendritic filopodium;GO:1990124,cellular_component messenger ribonucleoprotein complex;GO:1990812,cellular_component growth cone filopodium;GO:1990825,molecular_function sequence-specific mRNA binding;GO:1990904,cellular_component ribonucleoprotein complex;GO:2000301,biological_process negative regulation of synaptic vesicle exocytosis;GO:2000637,biological_process positive regulation of gene silencing by miRNA;GO:2000766,biological_process negative regulation of cytoplasmic translation;GO:2001022,biological_process positive regulation of response to DNA damage stimulus	FMR; fragile X mental retardation protein; K15516	fragile X mental retardation 1 [Source:HGNC Symbol%3BAcc:HGNC:3775]
ENSG00000186871	6.76	8.72	6.61	7.23	8.41	8.34	-0.1153754908917	4.8518947568097	0.308205926842233	0.688585907309328	X:72204656-72239047:-	ERCC6L	15;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0051301,biological_process cell division	NA	ERCC excision repair 6 like%2C spindle assembly checkpoint helicase [Source:HGNC Symbol%3BAcc:HGNC:20794]
ENSG00000116138	8.29	8.35	7.80	7.68	7.75	7.66	0.091770339330742	4.24057700841293	0.308261127922048	0.688585907309328	1:15526812-15592379:+	DNAJC16	5;GO:0005623,cellular_component cell;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045454,biological_process cell redox homeostasis	NA	DnaJ heat shock protein family (Hsp40) member C16 [Source:HGNC Symbol%3BAcc:HGNC:29157]
ENSG00000130045	7.86	6.38	6.22	5.00	6.53	6.57	0.194781213050507	2.16836284878107	0.308309470793976	0.688585907309328	9:88535100-88584274:+	NXNL2	7;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005737,cellular_component cytoplasm;GO:0007600,biological_process sensory perception;GO:0007601,biological_process visual perception;GO:0007608,biological_process sensory perception of smell;GO:0045494,biological_process photoreceptor cell maintenance;GO:0098869,biological_process cellular oxidant detoxification	NA	nucleoredoxin like 2 [Source:HGNC Symbol%3BAcc:HGNC:30482]
ENSG00000143549	193.93	197.87	198.96	206.39	209.06	205.08	-0.0592494816213454	7.94605225182638	0.308398047940102	0.688585907309328	1:154155303-154194648:-	TPM3	17;GO:0001725,cellular_component stress fiber;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005862,cellular_component muscle thin filament tropomyosin;GO:0005884,cellular_component actin filament;GO:0006928,biological_process movement of cell or subcellular component;GO:0006936,biological_process muscle contraction;GO:0007015,biological_process actin filament organization;GO:0008307,molecular_function structural constituent of muscle;GO:0015629,cellular_component actin cytoskeleton;GO:0030049,biological_process muscle filament sliding;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	TPM3; tropomyosin 3; K09290	tropomyosin 3 [Source:HGNC Symbol%3BAcc:HGNC:12012]
ENSG00000196369	13.54	14.85	12.29	15.28	13.88	14.71	-0.104258899130256	4.2882684960526	0.308453488821277	0.688585907309328	1:144887264-145095528:-	SRGAP2B	6;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0007399,biological_process nervous system development;GO:0030336,biological_process negative regulation of cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048365,molecular_function Rac GTPase binding	NA	SLIT-ROBO Rho GTPase activating protein 2B [Source:HGNC Symbol%3BAcc:HGNC:35237]
ENSG00000013503	3.30	3.60	2.99	2.89	3.41	2.77	0.131346527260409	3.43972899281083	0.30846853889727	0.688585907309328	12:106357657-106510198:+	POLR3B	19;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032549,molecular_function ribonucleoside binding;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus	NA	RNA polymerase III subunit B [Source:HGNC Symbol%3BAcc:HGNC:30348]
ENSG00000166548	10.73	9.01	11.85	15.00	9.37	11.45	-0.163569558036496	3.64400485444591	0.308475107833243	0.688585907309328	16:66508002-66552544:-	TK2	17;GO:0000166,molecular_function nucleotide binding;GO:0004137,molecular_function deoxycytidine kinase activity;GO:0004797,molecular_function thymidine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0009157,biological_process deoxyribonucleoside monophosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0046092,biological_process deoxycytidine metabolic process;GO:0046104,biological_process thymidine metabolic process;GO:0071897,biological_process DNA biosynthetic process	tdk, TK; thymidine kinase [EC:2.7.1.21]; K00857	thymidine kinase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:11831]
ENSG00000092330	32.55	30.94	31.97	31.50	29.94	30.29	0.0711814582778552	5.44778667214492	0.308485155123433	0.688585907309328	14:24239642-24242674:-	TINF2	19;GO:0000781,cellular_component chromosome, telomeric region;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0010370,cellular_component perinucleolar chromocenter;GO:0010836,biological_process negative regulation of protein ADP-ribosylation;GO:0016233,biological_process telomere capping;GO:0016363,cellular_component nuclear matrix;GO:0016604,cellular_component nuclear body;GO:0032202,biological_process telomere assembly;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0042162,molecular_function telomeric DNA binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0070187,cellular_component telosome;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:1904356,biological_process regulation of telomere maintenance via telomere lengthening	NA	TERF1 interacting nuclear factor 2 [Source:HGNC Symbol%3BAcc:HGNC:11824]
ENSG00000119865	18.36	12.35	16.32	15.64	18.87	18.39	-0.143707558329162	3.41737876072733	0.308584816170852	0.688594568922552	2:68284170-68320051:-	CNRIP1	1;GO:0043209,cellular_component myelin sheath	NA	cannabinoid receptor interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24546]
ENSG00000166510	3.79	2.38	4.03	4.32	3.77	3.92	-0.196216720124087	1.97107187305883	0.308599982833816	0.688594568922552	18:54901508-54959508:-	CCDC68	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 68 [Source:HGNC Symbol%3BAcc:HGNC:24350]
ENSG00000196998	16.70	14.29	15.48	16.29	16.41	17.14	-0.0835286901942747	4.73548123135719	0.309028784478961	0.689261485474586	X:49071469-49101170:-	WDR45	12;GO:0000422,biological_process mitophagy;GO:0005829,cellular_component cytosol;GO:0006497,biological_process protein lipidation;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019898,cellular_component extrinsic component of membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0044804,biological_process nucleophagy;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	WD repeat domain 45 [Source:HGNC Symbol%3BAcc:HGNC:28912]
ENSG00000140905	19.34	17.72	16.90	17.95	19.61	21.88	-0.127830087070567	3.4980643795587	0.309064316001473	0.689261485474586	16:81081937-81096425:-	GCSH	10;GO:0004047,molecular_function aminomethyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005960,cellular_component glycine cleavage complex;GO:0006546,biological_process glycine catabolic process;GO:0009249,biological_process protein lipoylation;GO:0019464,biological_process glycine decarboxylation via glycine cleavage system;GO:0032259,biological_process methylation;GO:0034641,biological_process cellular nitrogen compound metabolic process	gcvH, GCSH; glycine cleavage system H protein; K02437	glycine cleavage system protein H [Source:HGNC Symbol%3BAcc:HGNC:4208]
ENSG00000065613	18.09	16.04	19.17	16.59	17.26	17.23	0.0769623127547571	6.01608580140198	0.30908384100153	0.689261485474586	10:103967200-104029233:+	SLK	26;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030334,biological_process regulation of cell migration;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031252,cellular_component cell leading edge;GO:0032147,biological_process activation of protein kinase activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0045296,molecular_function cadherin binding;GO:0046777,biological_process protein autophosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0070062,cellular_component extracellular exosome	SLK; STE20-like kinase [EC:2.7.11.1]; K08836	STE20 like kinase [Source:HGNC Symbol%3BAcc:HGNC:11088]
ENSG00000183283	104.84	124.13	110.26	107.51	117.02	97.64	0.0842328525513022	6.46930816020925	0.309120977172079	0.689261485474586	12:51238291-51271362:+	DAZAP2	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016607,cellular_component nuclear speck;GO:0042802,molecular_function identical protein binding;GO:0050699,molecular_function WW domain binding	NA	DAZ associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:2684]
ENSG00000168385	263.69	272.14	273.34	282.11	284.76	282.33	-0.0579622455240206	8.84920093116489	0.309219323259197	0.689356943178235	2:241315099-241354027:+	SEPT2	37;GO:0000145,cellular_component exocyst;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005930,cellular_component axoneme;GO:0005938,cellular_component cell cortex;GO:0007049,biological_process cell cycle;GO:0007224,biological_process smoothened signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0031105,cellular_component septin complex;GO:0031175,biological_process neuron projection development;GO:0032154,cellular_component cleavage furrow;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097227,cellular_component sperm annulus;GO:0097730,cellular_component non-motile cilium	SEPT2; septin 2; K16942	septin 2 [Source:HGNC Symbol%3BAcc:HGNC:7729]
ENSG00000151743	8.30	8.60	10.51	13.31	7.30	11.09	-0.197158161316518	3.24814088317075	0.309318710178693	0.689454686559188	12:31671136-31729174:-	AMN1	NA	NA	antagonist of mitotic exit network 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:27281]
ENSG00000101361	66.09	65.03	66.61	71.93	67.11	69.31	-0.0634314202540158	6.99734123792235	0.309489128732867	0.689573060103128	20:2652144-2658393:+	NOP56	19;GO:0000154,biological_process rRNA modification;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031428,cellular_component box C/D snoRNP complex;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis;GO:0045296,molecular_function cadherin binding;GO:0070761,cellular_component pre-snoRNP complex;GO:1990226,molecular_function histone methyltransferase binding	NOP56; nucleolar protein 56; K14564	NOP56 ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:15911]
ENSG00000104635	20.54	18.49	19.23	19.01	16.27	19.97	0.0899455606292825	5.06379542975047	0.309531284340654	0.689573060103128	8:22367248-22434129:+	SLC39A14	21;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006826,biological_process iron ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0015093,molecular_function ferrous iron transmembrane transporter activity;GO:0015684,biological_process ferrous iron transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0030027,cellular_component lamellipodium;GO:0042995,cellular_component cell projection;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0071577,biological_process zinc II ion transmembrane transport;GO:0071578,biological_process zinc II ion transmembrane import;GO:1903874,biological_process ferrous iron transmembrane transport	SLC39A14, ZIP14; solute carrier family 39 (zinc transporter), member 14; K14720	solute carrier family 39 member 14 [Source:HGNC Symbol%3BAcc:HGNC:20858]
ENSG00000204172	18.28	16.46	17.45	15.51	17.75	16.53	0.0836849103289424	5.07672897635475	0.309571355813885	0.689573060103128	10:47501853-47523638:-	AGAP9	3;GO:0005096,molecular_function GTPase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	NA	ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 9 [Source:HGNC Symbol%3BAcc:HGNC:23463]
ENSG00000156140	3.81	5.18	3.52	4.74	5.20	3.99	-0.15319202063983	3.99955564881843	0.309594027548113	0.689573060103128	4:72280968-72569386:-	ADAMTS3	22;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0010573,biological_process vascular endothelial growth factor production;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0030199,biological_process collagen fibril organization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0032964,biological_process collagen biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0097435,biological_process fibril organization;GO:1900748,biological_process positive regulation of vascular endothelial growth factor signaling pathway	NA	ADAM metallopeptidase with thrombospondin type 1 motif 3 [Source:HGNC Symbol%3BAcc:HGNC:219]
ENSG00000019549	16.34	13.55	16.48	12.76	13.21	16.62	0.140259770133981	3.5999922574547	0.309673754550652	0.68962689544981	8:48917767-48921740:-	SNAI2	57;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001649,biological_process osteoblast differentiation;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003273,biological_process cell migration involved in endocardial cushion formation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006933,biological_process negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007605,biological_process sensory perception of sound;GO:0009314,biological_process response to radiation;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0010957,biological_process negative regulation of vitamin D biosynthetic process;GO:0014032,biological_process neural crest cell development;GO:0016477,biological_process cell migration;GO:0030335,biological_process positive regulation of cell migration;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0032642,biological_process regulation of chemokine production;GO:0033629,biological_process negative regulation of cell adhesion mediated by integrin;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0035921,biological_process desmosome disassembly;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043473,biological_process pigmentation;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0046872,molecular_function metal ion binding;GO:0050872,biological_process white fat cell differentiation;GO:0060021,biological_process palate development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060429,biological_process epithelium development;GO:0060536,biological_process cartilage morphogenesis;GO:0060693,biological_process regulation of branching involved in salivary gland morphogenesis;GO:0070563,biological_process negative regulation of vitamin D receptor signaling pathway;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071479,biological_process cellular response to ionizing radiation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1900387,biological_process negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2000647,biological_process negative regulation of stem cell proliferation;GO:2000810,biological_process regulation of bicellular tight junction assembly;GO:2000811,biological_process negative regulation of anoikis;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	SNAI2, SLUG; snail 2; K05706	snail family transcriptional repressor 2 [Source:HGNC Symbol%3BAcc:HGNC:11094]
ENSG00000136153	8.89	9.10	7.95	8.21	8.53	8.04	0.0749961545491141	5.54067862254882	0.309732773221249	0.689634603407239	13:75620433-75859870:+	LMO7	19;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016567,biological_process protein ubiquitination;GO:0023051,biological_process regulation of signaling;GO:0030155,biological_process regulation of cell adhesion;GO:0042805,molecular_function actinin binding;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	LMO7, FBXO20; F-box protein 20; K06084	LIM domain 7 [Source:HGNC Symbol%3BAcc:HGNC:6646]
ENSG00000112855	26.32	23.03	24.06	23.51	24.61	21.99	0.0829591955725725	5.28186088180655	0.30988699129353	0.689854236536332	5:140691425-140699291:+	HARS2	14;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004821,molecular_function histidine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006427,biological_process histidyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity;GO:0042803,molecular_function protein homodimerization activity	HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]; K01892	histidyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:4817]
ENSG00000243284	1.14	1.15	1.30	1.09	1.53	1.87	-0.30695092995099	0.876458443687681	0.309944160954349	0.689857785534577	1:159854315-159862657:-	VSIG8	4;GO:0003723,molecular_function RNA binding;GO:0005622,cellular_component intracellular;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	V-set and immunoglobulin domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:32063]
ENSG00000219545	12.64	10.47	9.19	9.88	14.65	12.09	-0.165705578468883	3.31240822863192	0.310091771580538	0.690062596025317	7:7640710-7968020:+	UMAD1	NA	NA	UBAP1-MVB12-associated (UMA) domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:48955]
ENSG00000120029	11.60	11.65	11.76	12.10	12.39	12.80	-0.0795758908874045	4.7685196385336	0.310149815383677	0.690068051327762	10:101845598-102056193:-	C10orf76	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 10 open reading frame 76 [Source:HGNC Symbol%3BAcc:HGNC:25788]
ENSG00000164300	4.82	4.61	5.97	5.16	3.66	5.02	0.169421641742016	2.95371527591896	0.310598916054481	0.690918473328806	5:80111650-80256079:-	SERINC5	25;GO:0002376,biological_process immune system process;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006564,biological_process L-serine biosynthetic process;GO:0006629,biological_process lipid metabolic process;GO:0006658,biological_process phosphatidylserine metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006810,biological_process transport;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009597,biological_process detection of virus;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015825,biological_process L-serine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0042552,biological_process myelination;GO:0043209,cellular_component myelin sheath;GO:0045087,biological_process innate immune response;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051607,biological_process defense response to virus;GO:0070062,cellular_component extracellular exosome;GO:1904219,biological_process positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:1904222,biological_process positive regulation of serine C-palmitoyltransferase activity;GO:1905361,molecular_function L-serine transporter activity	NA	serine incorporator 5 [Source:HGNC Symbol%3BAcc:HGNC:18825]
ENSG00000240184	19.99	21.66	20.01	18.96	20.54	19.69	0.0677180227183167	5.90130007866217	0.310643357741727	0.690918473328806	5:141475946-141512979:+	PCDHGC3	11;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0070062,cellular_component extracellular exosome	NA	protocadherin gamma subfamily C%2C 3 [Source:HGNC Symbol%3BAcc:HGNC:8716]
ENSG00000169756	33.16	31.86	35.21	35.67	34.52	35.95	-0.0685884768799602	5.65768508618968	0.310865077521792	0.691287747631316	2:108534354-108687246:+	LIMS1	25;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0007569,biological_process cell aging;GO:0008270,molecular_function zinc ion binding;GO:0010628,biological_process positive regulation of gene expression;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034329,biological_process cell junction assembly;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045184,biological_process establishment of protein localization;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051291,biological_process protein heterooligomerization;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling	NA	LIM zinc finger domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:6616]
ENSG00000123159	75.45	80.11	70.91	67.09	81.76	65.99	0.0868463720619622	6.25807752596476	0.311042362843231	0.691558096000901	19:14477759-14496149:-	GIPC1	29;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005903,cellular_component brush border;GO:0005938,cellular_component cell cortex;GO:0006605,biological_process protein targeting;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0008021,cellular_component synaptic vesicle;GO:0012506,cellular_component vesicle membrane;GO:0014047,biological_process glutamate secretion;GO:0016020,cellular_component membrane;GO:0017022,molecular_function myosin binding;GO:0030139,cellular_component endocytic vesicle;GO:0030165,molecular_function PDZ domain binding;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031647,biological_process regulation of protein stability;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032467,biological_process positive regulation of cytokinesis;GO:0042803,molecular_function protein homodimerization activity;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0043542,biological_process endothelial cell migration;GO:0045296,molecular_function cadherin binding;GO:0048167,biological_process regulation of synaptic plasticity;GO:0070062,cellular_component extracellular exosome	NA	GIPC PDZ domain containing family member 1 [Source:HGNC Symbol%3BAcc:HGNC:1226]
ENSG00000105556	7.73	7.54	8.24	7.46	7.38	7.18	0.109670627749018	3.65159997720378	0.311215694903341	0.691819559605152	19:301443-344815:-	MIER2	9;GO:0003677,molecular_function DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016575,biological_process histone deacetylation;GO:0042826,molecular_function histone deacetylase binding;GO:0043234,cellular_component protein complex	NA	MIER family member 2 [Source:HGNC Symbol%3BAcc:HGNC:29210]
ENSG00000167740	20.42	19.82	20.77	20.62	18.87	18.07	0.0990517019633729	4.11354986856355	0.311298692632082	0.691880156068404	17:4143167-4187310:+	CYB5D2	6;GO:0005576,cellular_component extracellular region;GO:0007399,biological_process nervous system development;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0020037,molecular_function heme binding;GO:0045666,biological_process positive regulation of neuron differentiation	NA	cytochrome b5 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28471]
ENSG00000092108	37.76	38.89	37.90	36.82	36.17	37.53	0.0623035087787843	6.28498673732494	0.311464310052501	0.692118933914629	14:30622111-30735812:+	SCFD1	31;GO:0000902,biological_process cell morphogenesis;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005801,cellular_component cis-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006909,biological_process phagocytosis;GO:0009636,biological_process response to toxic substance;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017119,cellular_component Golgi transport complex;GO:0019905,molecular_function syntaxin binding;GO:0031201,cellular_component SNARE complex;GO:0032580,cellular_component Golgi cisterna membrane;GO:0047485,molecular_function protein N-terminus binding;GO:0048208,biological_process COPII vesicle coating;GO:0051223,biological_process regulation of protein transport;GO:0060628,biological_process regulation of ER to Golgi vesicle-mediated transport;GO:1901998,biological_process toxin transport;GO:1902902,biological_process negative regulation of autophagosome assembly	NA	sec1 family domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20726]
ENSG00000134901	15.85	17.26	14.81	13.87	15.66	15.64	0.0908050705262677	4.55327086150478	0.311517641487234	0.692118933914629	13:102784280-102799007:-	KDELC1	4;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006664,biological_process glycolipid metabolic process;GO:0046527,molecular_function glucosyltransferase activity	NA	KDEL motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19350]
ENSG00000086758	35.85	37.43	35.30	38.66	37.36	38.03	-0.0594859866421041	8.95587428819274	0.311715443811777	0.692318986491192	X:53532095-53686729:-	HUWE1	26;GO:0000209,biological_process protein polyubiquitination;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016574,biological_process histone ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0034774,cellular_component secretory granule lumen;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1904813,cellular_component ficolin-1-rich granule lumen	HUWE1, MULE, ARF-BP1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]; K10592	HECT%2C UBA and WWE domain containing 1%2C E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:30892]
ENSG00000116161	123.90	125.32	116.32	118.66	120.64	112.37	0.0668982437675758	6.35623835797492	0.311719231088316	0.692318986491192	1:174999162-175011715:+	CACYBP	22;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005641,cellular_component nuclear envelope lumen;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007507,biological_process heart development;GO:0007568,biological_process aging;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019904,molecular_function protein domain specific binding;GO:0030877,cellular_component beta-catenin destruction complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0044297,cellular_component cell body;GO:0045740,biological_process positive regulation of DNA replication;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060416,biological_process response to growth hormone;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:0071277,biological_process cellular response to calcium ion;GO:1990830,biological_process cellular response to leukemia inhibitory factor	CACYBP, SIP; calcyclin binding protein; K04507	calcyclin binding protein [Source:HGNC Symbol%3BAcc:HGNC:30423]
ENSG00000164967	23.11	22.67	19.72	18.07	21.40	20.85	0.127428686004155	3.377595402218	0.311777580354914	0.692324705714768	9:34610485-34612104:-	RPP25L	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]; K14525	ribonuclease P/MRP subunit p25 like [Source:HGNC Symbol%3BAcc:HGNC:19909]
ENSG00000137055	14.57	14.23	12.78	13.66	16.18	14.68	-0.0876084042165559	5.10720489938773	0.311841077837936	0.692341852835324	9:26904082-26947463:-	PLAA	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006644,biological_process phospholipid metabolic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0010992,biological_process ubiquitin homeostasis;GO:0016005,molecular_function phospholipase A2 activator activity;GO:0016236,biological_process macroautophagy;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070062,cellular_component extracellular exosome	PLAA, DOA1, UFD3; phospholipase A-2-activating protein; K14018	phospholipase A2 activating protein [Source:HGNC Symbol%3BAcc:HGNC:9043]
ENSG00000147224	37.96	44.38	39.00	43.66	43.50	41.80	-0.0815067880909884	5.46091359151598	0.312159022606385	0.692641379567206	X:107628423-107651026:+	PRPS1	32;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002189,cellular_component ribose phosphate diphosphokinase complex;GO:0004749,molecular_function ribose phosphate diphosphokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006015,biological_process 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006144,biological_process purine nucleobase metabolic process;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006167,biological_process AMP biosynthetic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0007399,biological_process nervous system development;GO:0009116,biological_process nucleoside metabolic process;GO:0009156,biological_process ribonucleoside monophosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016208,molecular_function AMP binding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019003,molecular_function GDP binding;GO:0019693,biological_process ribose phosphate metabolic process;GO:0030246,molecular_function carbohydrate binding;GO:0031100,biological_process organ regeneration;GO:0034418,biological_process urate biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043531,molecular_function ADP binding;GO:0044249,biological_process cellular biosynthetic process;GO:0046101,biological_process hypoxanthine biosynthetic process;GO:0046872,molecular_function metal ion binding	PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]; K00948	phosphoribosyl pyrophosphate synthetase 1 [Source:HGNC Symbol%3BAcc:HGNC:9462]
ENSG00000174405	4.19	4.09	4.36	3.56	3.91	4.25	0.121270712016987	3.49299688720091	0.31218586961544	0.692641379567206	13:108207438-108218368:-	LIG4	56;GO:0000012,biological_process single strand break repair;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000793,cellular_component condensed chromosome;GO:0001701,biological_process in utero embryonic development;GO:0002328,biological_process pro-B cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003909,molecular_function DNA ligase activity;GO:0003910,molecular_function DNA ligase (ATP) activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005958,cellular_component DNA-dependent protein kinase-DNA ligase 4 complex;GO:0006260,biological_process DNA replication;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007417,biological_process central nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0010165,biological_process response to X-ray;GO:0010212,biological_process response to ionizing radiation;GO:0010332,biological_process response to gamma radiation;GO:0016874,molecular_function ligase activity;GO:0032807,cellular_component DNA ligase IV complex;GO:0033077,biological_process T cell differentiation in thymus;GO:0033151,biological_process V(D)J recombination;GO:0033152,biological_process immunoglobulin V(D)J recombination;GO:0033153,biological_process T cell receptor V(D)J recombination;GO:0035019,biological_process somatic stem cell population maintenance;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045190,biological_process isotype switching;GO:0046872,molecular_function metal ion binding;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0050769,biological_process positive regulation of neurogenesis;GO:0051102,biological_process DNA ligation involved in DNA recombination;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0051402,biological_process neuron apoptotic process;GO:0070419,cellular_component nonhomologous end joining complex;GO:0071285,biological_process cellular response to lithium ion;GO:0071897,biological_process DNA biosynthetic process;GO:0075713,biological_process establishment of integrated proviral latency;GO:0097680,biological_process double-strand break repair via classical nonhomologous end joining;GO:2001252,biological_process positive regulation of chromosome organization	LIG4, DNL4; DNA ligase 4 [EC:6.5.1.1]; K10777	DNA ligase 4 [Source:HGNC Symbol%3BAcc:HGNC:6601]
ENSG00000241635	3.56	2.00	2.62	2.35	2.56	2.20	0.235761811671157	2.11744304808908	0.312283909691352	0.692641379567206	2:233760247-233773299:+	UGT1A1	51;GO:0001889,biological_process liver development;GO:0001972,molecular_function retinoic acid binding;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005496,molecular_function steroid binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006789,biological_process bilirubin conjugation;GO:0006953,biological_process acute-phase response;GO:0007584,biological_process response to nutrient;GO:0007586,biological_process digestion;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0010033,biological_process response to organic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0017144,biological_process drug metabolic process;GO:0019899,molecular_function enzyme binding;GO:0031100,biological_process organ regeneration;GO:0032496,biological_process response to lipopolysaccharide;GO:0032870,biological_process cellular response to hormone stimulus;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0042167,biological_process heme catabolic process;GO:0042493,biological_process response to drug;GO:0042573,biological_process retinoic acid metabolic process;GO:0042594,biological_process response to starvation;GO:0042803,molecular_function protein homodimerization activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045471,biological_process response to ethanol;GO:0045939,biological_process negative regulation of steroid metabolic process;GO:0046483,biological_process heterocycle metabolic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0048545,biological_process response to steroid hormone;GO:0051384,biological_process response to glucocorticoid;GO:0051552,biological_process flavone metabolic process;GO:0052695,biological_process cellular glucuronidation;GO:0052696,biological_process flavonoid glucuronidation;GO:0052697,biological_process xenobiotic glucuronidation;GO:0070069,cellular_component cytochrome complex;GO:0070980,biological_process biphenyl catabolic process;GO:0071361,biological_process cellular response to ethanol;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071466,biological_process cellular response to xenobiotic stimulus	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 1 member A1 [Source:HGNC Symbol%3BAcc:HGNC:12530]
ENSG00000154040	0.61	1.23	0.91	0.54	0.83	0.84	0.291594501640287	0.88873019525364	0.312290378042933	0.692641379567206	18:24138955-24161603:+	CABYR	17;GO:0003351,biological_process epithelial cilium movement;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0017124,molecular_function SH3 domain binding;GO:0019904,molecular_function protein domain specific binding;GO:0031514,cellular_component motile cilium;GO:0035686,cellular_component sperm fibrous sheath;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048240,biological_process sperm capacitation;GO:0097228,cellular_component sperm principal piece;GO:0097229,cellular_component sperm end piece	NA	calcium binding tyrosine phosphorylation regulated [Source:HGNC Symbol%3BAcc:HGNC:15569]
ENSG00000198792	31.10	33.33	30.94	31.18	30.07	30.10	0.0703674792384602	5.34166182317788	0.312308841876418	0.692641379567206	22:38219290-38273034:-	TMEM184B	4;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 184B [Source:HGNC Symbol%3BAcc:HGNC:1310]
ENSG00000110723	0.89	0.80	0.94	1.33	0.88	0.85	-0.199288792143512	2.54200200769515	0.312310787193881	0.692641379567206	11:108505430-108593738:-	EXPH5	7;GO:0003334,biological_process keratinocyte development;GO:0005768,cellular_component endosome;GO:0006886,biological_process intracellular protein transport;GO:0017137,molecular_function Rab GTPase binding;GO:0045921,biological_process positive regulation of exocytosis;GO:0050714,biological_process positive regulation of protein secretion;GO:0071985,biological_process multivesicular body sorting pathway	NA	exophilin 5 [Source:HGNC Symbol%3BAcc:HGNC:30578]
ENSG00000266094	1.30	1.35	1.40	1.52	1.77	1.56	-0.243481393162377	1.36238576262929	0.312374556394438	0.692659051183308	1:206507529-206589448:+	RASSF5	15;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0017016,molecular_function Ras GTPase binding;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:1900180,biological_process regulation of protein localization to nucleus	RASSF5, RAPL; Ras association domain-containing protein 5; K08015	Ras association domain family member 5 [Source:HGNC Symbol%3BAcc:HGNC:17609]
ENSG00000152223	6.89	6.84	6.57	6.58	6.33	6.63	0.066198844174084	5.69817198477963	0.312575496452201	0.692836863778156	18:45847608-45967274:-	EPG5	4;GO:0005737,cellular_component cytoplasm;GO:0006914,biological_process autophagy;GO:0032456,biological_process endocytic recycling;GO:0097352,biological_process autophagosome maturation	NA	ectopic P-granules autophagy protein 5 homolog [Source:HGNC Symbol%3BAcc:HGNC:29331]
ENSG00000196878	14.74	10.57	14.84	16.33	11.24	17.28	-0.14494563158862	5.64980120303851	0.312614898982692	0.692836863778156	1:209614869-209652466:-	LAMB3	14;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005610,cellular_component laminin-5 complex;GO:0007155,biological_process cell adhesion;GO:0008544,biological_process epidermis development;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0031581,biological_process hemidesmosome assembly;GO:0032403,molecular_function protein complex binding;GO:0035987,biological_process endodermal cell differentiation;GO:0050873,biological_process brown fat cell differentiation	LAMB3; laminin, beta 3; K06244	laminin subunit beta 3 [Source:HGNC Symbol%3BAcc:HGNC:6490]
ENSG00000213593	58.87	63.15	63.86	65.12	65.80	65.16	-0.066729895044798	5.94810647231351	0.312622192380686	0.692836863778156	11:57712599-57740973:+	TMX2	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005623,cellular_component cell;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045454,biological_process cell redox homeostasis	NA	thioredoxin related transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:30739]
ENSG00000100105	8.07	8.79	9.13	10.09	9.02	8.91	-0.0978899074629961	4.40591968111154	0.312847769373728	0.693213024140678	22:31325803-31346232:-	PATZ1	18;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0008584,biological_process male gonad development;GO:0010468,biological_process regulation of gene expression;GO:0030217,biological_process T cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	POZ/BTB and AT hook containing zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:13071]
ENSG00000170265	13.37	11.49	12.94	14.25	13.19	13.17	-0.0844566423568927	4.72968452843527	0.313096407820754	0.693640141045692	7:149195484-149226248:+	ZNF282	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 282 [Source:HGNC Symbol%3BAcc:HGNC:13076]
ENSG00000166473	0.76	0.55	0.60	0.66	0.42	0.59	0.217572282688226	2.23904633312465	0.313307399268405	0.693738222400516	16:81100874-81220370:-	PKD1L2	9;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0050982,biological_process detection of mechanical stimulus;GO:0070588,biological_process calcium ion transmembrane transport	NA	polycystin 1 like 2 (gene/pseudogene) [Source:HGNC Symbol%3BAcc:HGNC:21715]
ENSG00000150995	7.15	6.26	6.89	6.22	6.01	7.15	0.0816709126327566	5.78071714288522	0.313331814997657	0.693738222400516	3:4493347-4847840:+	ITPR1	50;GO:0001666,biological_process response to hypoxia;GO:0005216,molecular_function ion channel activity;GO:0005220,molecular_function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005955,cellular_component calcineurin complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0009791,biological_process post-embryonic development;GO:0010506,biological_process regulation of autophagy;GO:0014069,cellular_component postsynaptic density;GO:0015085,molecular_function calcium ion transmembrane transporter activity;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0030168,biological_process platelet activation;GO:0030658,cellular_component transport vesicle membrane;GO:0031088,cellular_component platelet dense granule membrane;GO:0031094,cellular_component platelet dense tubular network;GO:0031095,cellular_component platelet dense tubular network membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0034220,biological_process ion transmembrane transport;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042045,biological_process epithelial fluid transport;GO:0043234,cellular_component protein complex;GO:0048016,biological_process inositol phosphate-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050796,biological_process regulation of insulin secretion;GO:0050849,biological_process negative regulation of calcium-mediated signaling;GO:0050882,biological_process voluntary musculoskeletal movement;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0055085,biological_process transmembrane transport;GO:0065009,biological_process regulation of molecular function;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070588,biological_process calcium ion transmembrane transport;GO:1903779,biological_process regulation of cardiac conduction	ITPR1; inositol 1,4,5-triphosphate receptor type 1; K04958	inositol 1%2C4%2C5-trisphosphate receptor type 1 [Source:HGNC Symbol%3BAcc:HGNC:6180]
ENSG00000130544	3.61	5.33	4.56	4.06	4.23	3.65	0.173498292618321	2.47836146936641	0.31334307999437	0.693738222400516	19:7069443-7087968:+	ZNF557	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 557 [Source:HGNC Symbol%3BAcc:HGNC:28632]
ENSG00000139437	6.76	7.10	6.11	7.27	7.31	7.30	-0.125664342725277	3.40153984003024	0.313364232095359	0.693738222400516	12:109900263-109983841:+	TCHP	18;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0030308,biological_process negative regulation of cell growth;GO:0045095,cellular_component keratin filament;GO:0045179,cellular_component apical cortex;GO:0097539,cellular_component ciliary transition fiber;GO:1902018,biological_process negative regulation of cilium assembly	NA	trichoplein keratin filament binding [Source:HGNC Symbol%3BAcc:HGNC:28135]
ENSG00000112992	38.86	42.75	42.61	38.52	41.43	39.51	0.0673390559760803	7.05742818760949	0.313514814399938	0.693947822957636	5:43602691-43707405:+	NNT	17;GO:0003957,molecular_function NAD(P)+ transhydrogenase (B-specific) activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006740,biological_process NADPH regeneration;GO:0008746,molecular_function NAD(P)+ transhydrogenase activity;GO:0008750,molecular_function NAD(P)+ transhydrogenase (AB-specific) activity;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0050661,molecular_function NADP binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0072593,biological_process reactive oxygen species metabolic process;GO:1902600,biological_process hydrogen ion transmembrane transport	NNT; H+-translocating NAD(P) transhydrogenase [EC:1.6.1.2 7.1.1.1]; K00323	nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol%3BAcc:HGNC:7863]
ENSG00000179820	62.95	57.87	58.44	56.04	57.55	59.04	0.0679465736269122	5.82937298524147	0.313745254917473	0.694334079032018	19:53866222-53876437:+	MYADM	19;GO:0001726,cellular_component ruffle;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031579,biological_process membrane raft organization;GO:0034115,biological_process negative regulation of heterotypic cell-cell adhesion;GO:0045121,cellular_component membrane raft;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0072661,biological_process protein targeting to plasma membrane;GO:0090038,biological_process negative regulation of protein kinase C signaling;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	NA	myeloid associated differentiation marker [Source:HGNC Symbol%3BAcc:HGNC:7544]
ENSG00000138587	8.23	9.52	7.14	8.67	11.08	8.00	-0.151692575635236	3.71554026354434	0.313916992078947	0.694491915192877	15:56421543-56465137:-	MNS1	12;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005882,cellular_component intermediate filament;GO:0005930,cellular_component axoneme;GO:0007283,biological_process spermatogenesis;GO:0031514,cellular_component motile cilium;GO:0036126,cellular_component sperm flagellum;GO:0042802,molecular_function identical protein binding;GO:0044782,biological_process cilium organization;GO:0045724,biological_process positive regulation of cilium assembly;GO:0051321,biological_process meiotic cell cycle;GO:0070986,biological_process left/right axis specification	NA	meiosis specific nuclear structural 1 [Source:HGNC Symbol%3BAcc:HGNC:29636]
ENSG00000133794	10.60	9.34	10.47	11.83	9.66	11.43	-0.0984576229340675	4.52441041243829	0.313928473064306	0.694491915192877	11:13276651-13387266:+	ARNTL	52;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0007623,biological_process circadian rhythm;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032922,biological_process circadian regulation of gene expression;GO:0033391,cellular_component chromatoid body;GO:0042176,biological_process regulation of protein catabolic process;GO:0042634,biological_process regulation of hair cycle;GO:0042753,biological_process positive regulation of circadian rhythm;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0050767,biological_process regulation of neurogenesis;GO:0050796,biological_process regulation of insulin secretion;GO:0051726,biological_process regulation of cell cycle;GO:0051775,biological_process response to redox state;GO:0051879,molecular_function Hsp90 protein binding;GO:0060137,biological_process maternal process involved in parturition;GO:0070491,molecular_function repressing transcription factor binding;GO:0070888,molecular_function E-box binding;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0090403,biological_process oxidative stress-induced premature senescence;GO:2000074,biological_process regulation of type B pancreatic cell development;GO:2000323,biological_process negative regulation of glucocorticoid receptor signaling pathway;GO:2000772,biological_process regulation of cellular senescence;GO:2001016,biological_process positive regulation of skeletal muscle cell differentiation	NA	aryl hydrocarbon receptor nuclear translocator like [Source:HGNC Symbol%3BAcc:HGNC:701]
ENSG00000178295	7.26	7.54	6.97	8.02	8.02	7.33	-0.0928201444876353	4.36789606220677	0.31408136522962	0.694706341160954	2:17753857-17788941:+	GEN1	20;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0010824,biological_process regulation of centrosome duplication;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071139,biological_process resolution of recombination intermediates;GO:0071140,biological_process resolution of mitotic recombination intermediates;GO:0090267,biological_process positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	GEN1%2C Holliday junction 5' flap endonuclease [Source:HGNC Symbol%3BAcc:HGNC:26881]
ENSG00000090581	79.54	83.42	78.63	73.88	80.23	78.39	0.0655842043925579	6.38268245258823	0.3142782109553	0.694928262153732	16:1351922-1364113:+	GNPTG	10;GO:0000139,cellular_component Golgi membrane;GO:0003976,molecular_function UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016256,biological_process N-glycan processing to lysosome;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046835,biological_process carbohydrate phosphorylation;GO:0070062,cellular_component extracellular exosome	GNPTG, GNPTAG; N-acetylglucosamine-1-phosphate transferase, gamma subunit; K10087	N-acetylglucosamine-1-phosphate transferase gamma subunit [Source:HGNC Symbol%3BAcc:HGNC:23026]
ENSG00000185716	11.02	13.65	11.48	9.22	12.08	11.20	0.153030900620772	2.82364099747771	0.314293665006932	0.694928262153732	16:22007637-22087534:+	C16orf52	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 16 open reading frame 52 [Source:HGNC Symbol%3BAcc:HGNC:27087]
ENSG00000137574	16.89	15.87	15.73	16.79	16.77	17.81	-0.0705434947938539	5.41972992497168	0.314552419554913	0.695216247770873	8:55773141-55825448:+	TGS1	23;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0001510,biological_process RNA methylation;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0009452,biological_process 7-methylguanosine RNA capping;GO:0015030,cellular_component Cajal body;GO:0016740,molecular_function transferase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0022613,biological_process ribonucleoprotein complex biogenesis;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0032259,biological_process methylation;GO:0036261,biological_process 7-methylguanosine cap hypermethylation;GO:0071164,molecular_function RNA trimethylguanosine synthase activity;GO:0071167,biological_process ribonucleoprotein complex import into nucleus	TGS1; trimethylguanosine synthase [EC:2.1.1.-]; K14292	trimethylguanosine synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:17843]
ENSG00000105379	51.99	51.58	51.96	49.57	50.91	49.51	0.0643914781855036	5.80565151243954	0.314635301899814	0.695216247770873	19:51345168-51366418:-	ETFB	10;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006479,biological_process protein methylation;GO:0009055,molecular_function electron carrier activity;GO:0022904,biological_process respiratory electron transport chain;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	electron transfer flavoprotein beta subunit [Source:HGNC Symbol%3BAcc:HGNC:3482]
ENSG00000197557	5.31	5.65	5.90	6.34	5.97	6.06	-0.113150039976896	3.57052075732455	0.314675508150934	0.695216247770873	2:177612991-177618966:-	TTC30A	6;GO:0005929,cellular_component cilium;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	tetratricopeptide repeat domain 30A [Source:HGNC Symbol%3BAcc:HGNC:25853]
ENSG00000116183	0.25	0.07	0.39	0.59	0.08	0.38	-0.527899839980246	0.84458770463359	0.314692942521874	0.695216247770873	1:176463170-176845605:+	PAPPA2	13;GO:0001558,biological_process regulation of cell growth;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0060349,biological_process bone morphogenesis;GO:0070062,cellular_component extracellular exosome	NA	pappalysin 2 [Source:HGNC Symbol%3BAcc:HGNC:14615]
ENSG00000081386	6.22	6.46	7.15	7.52	7.15	6.86	-0.10533855790045	3.87303120822033	0.314748123573715	0.695216247770873	9:96755864-96778129:-	ZNF510	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 510 [Source:HGNC Symbol%3BAcc:HGNC:29161]
ENSG00000106483	6.08	6.72	5.58	6.51	7.72	6.31	-0.155116983609642	2.83777495400901	0.314842500012931	0.695216247770873	7:37905931-38025695:-	SFRP4	31;GO:0002092,biological_process positive regulation of receptor internalization;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009725,biological_process response to hormone;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0030154,biological_process cell differentiation;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030510,biological_process regulation of BMP signaling pathway;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045606,biological_process positive regulation of epidermal cell differentiation;GO:0055062,biological_process phosphate ion homeostasis;GO:0060349,biological_process bone morphogenesis;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902174,biological_process positive regulation of keratinocyte apoptotic process;GO:2000051,biological_process negative regulation of non-canonical Wnt signaling pathway;GO:2000119,biological_process negative regulation of sodium-dependent phosphate transport	SFRP4; secreted frizzled-related protein 4; K02185	secreted frizzled related protein 4 [Source:HGNC Symbol%3BAcc:HGNC:10778]
ENSG00000121542	25.77	32.79	23.33	25.93	25.69	24.36	0.11099964771747	4.60073813925437	0.314911605466042	0.695216247770873	3:123201926-123274130:+	SEC22A	14;GO:0000149,molecular_function SNARE binding;GO:0005215,molecular_function transporter activity;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031201,cellular_component SNARE complex;GO:0048280,biological_process vesicle fusion with Golgi apparatus	NA	SEC22 homolog A%2C vesicle trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:20260]
ENSG00000075426	104.67	101.90	98.69	105.93	108.52	107.01	-0.0627702852745413	6.7883435099503	0.314921988903088	0.695216247770873	2:28392447-28417312:+	FOSL2	17;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003334,biological_process keratinocyte development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008219,biological_process cell death;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048146,biological_process positive regulation of fibroblast proliferation	FOSL2; fos-like antigen 2; K09030	FOS like 2%2C AP-1 transcription factor subunit [Source:HGNC Symbol%3BAcc:HGNC:3798]
ENSG00000099624	62.08	65.42	55.35	50.81	61.40	60.13	0.0931418422014922	4.90449851641255	0.314927975607478	0.695216247770873	19:1241745-1244826:+	ATP5D	23;GO:0000275,cellular_component mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005759,cellular_component mitochondrial matrix;GO:0006119,biological_process oxidative phosphorylation;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0043531,molecular_function ADP binding;GO:0045261,cellular_component proton-transporting ATP synthase complex, catalytic core F(1);GO:0046688,biological_process response to copper ion;GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF1D, ATP5D, ATP16; F-type H+-transporting ATPase subunit delta; K02134	ATP synthase%2C H+ transporting%2C mitochondrial F1 complex%2C delta subunit [Source:HGNC Symbol%3BAcc:HGNC:837]
ENSG00000165775	55.54	60.42	53.64	51.40	62.09	45.05	0.107711065704502	5.01585610163044	0.315054217345176	0.695354768502345	X:155025979-155060303:+	FUNDC2	6;GO:0000422,biological_process mitophagy;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031307,cellular_component integral component of mitochondrial outer membrane	NA	FUN14 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24925]
ENSG00000138777	83.64	93.86	85.84	83.25	86.11	83.54	0.0678585752409469	6.51846493196071	0.315174634169141	0.695354768502345	4:105369076-105474081:-	PPA2	14;GO:0000287,molecular_function magnesium ion binding;GO:0004427,molecular_function inorganic diphosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006470,biological_process protein dephosphorylation;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0070062,cellular_component extracellular exosome;GO:0071344,biological_process diphosphate metabolic process	ppa; inorganic pyrophosphatase [EC:3.6.1.1]; K01507	pyrophosphatase (inorganic) 2 [Source:HGNC Symbol%3BAcc:HGNC:28883]
ENSG00000087253	17.12	15.06	18.96	19.46	17.31	18.31	-0.0893009587093625	4.9814238248613	0.315234063561404	0.695354768502345	16:55508997-55586670:+	LPCAT2	23;GO:0000139,cellular_component Golgi membrane;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005811,cellular_component lipid particle;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006663,biological_process platelet activating factor biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0046872,molecular_function metal ion binding;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184,molecular_function 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192,molecular_function 1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0061024,biological_process membrane organization	LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]; K13510	lysophosphatidylcholine acyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:26032]
ENSG00000183718	14.35	12.87	11.90	15.38	14.39	13.18	-0.119379685558126	3.62735882937476	0.315265734606198	0.695354768502345	5:181254416-181261139:-	TRIM52	4;GO:0005622,cellular_component intracellular;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	NA	tripartite motif containing 52 [Source:HGNC Symbol%3BAcc:HGNC:19024]
ENSG00000117054	51.58	50.73	52.42	47.71	50.40	51.16	0.0639980084301207	6.18102562258761	0.315340597938769	0.695354768502345	1:75724346-75787575:+	ACADM	33;GO:0001889,biological_process liver development;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005978,biological_process glycogen biosynthetic process;GO:0006082,biological_process organic acid metabolic process;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0007507,biological_process heart development;GO:0008152,biological_process metabolic process;GO:0009409,biological_process response to cold;GO:0009437,biological_process carnitine metabolic process;GO:0009791,biological_process post-embryonic development;GO:0016491,molecular_function oxidoreductase activity;GO:0016607,cellular_component nuclear speck;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019254,biological_process carnitine metabolic process, CoA-linked;GO:0030424,cellular_component axon;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0042594,biological_process response to starvation;GO:0042802,molecular_function identical protein binding;GO:0045329,biological_process carnitine biosynthetic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051791,biological_process medium-chain fatty acid metabolic process;GO:0051793,biological_process medium-chain fatty acid catabolic process;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070991,molecular_function medium-chain-acyl-CoA dehydrogenase activity	ACADM, acd; acyl-CoA dehydrogenase [EC:1.3.8.7]; K00249	acyl-CoA dehydrogenase%2C C-4 to C-12 straight chain [Source:HGNC Symbol%3BAcc:HGNC:89]
ENSG00000101413	16.23	16.62	15.54	17.97	16.44	17.66	-0.0971301654540245	4.18293126469719	0.315361192136902	0.695354768502345	20:38033545-38127780:+	RPRD1B	14;GO:0000993,molecular_function RNA polymerase II core binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010564,biological_process regulation of cell cycle process;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070940,biological_process dephosphorylation of RNA polymerase II C-terminal domain	NA	regulation of nuclear pre-mRNA domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:16209]
ENSG00000136104	15.16	13.61	13.69	16.89	14.40	14.88	-0.105061185091032	3.91864256285468	0.315382852386063	0.695354768502345	13:50909677-50973745:+	RNASEH2B	11;GO:0001701,biological_process in utero embryonic development;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0005634,cellular_component nucleus;GO:0006401,biological_process RNA catabolic process;GO:0009259,biological_process ribonucleotide metabolic process;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010629,biological_process negative regulation of gene expression;GO:0032299,cellular_component ribonuclease H2 complex;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:2000001,biological_process regulation of DNA damage checkpoint	RNASEH2B; ribonuclease H2 subunit B; K10744	ribonuclease H2 subunit B [Source:HGNC Symbol%3BAcc:HGNC:25671]
ENSG00000130559	10.19	9.95	10.05	10.52	10.34	11.01	-0.0664433866832897	5.65168169708591	0.31547714719296	0.695383767840782	9:135808486-135907228:-	CAMSAP1	9;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0008017,molecular_function microtubule binding;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030507,molecular_function spectrin binding;GO:0031175,biological_process neuron projection development	NA	calmodulin regulated spectrin associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19946]
ENSG00000250312	5.12	6.00	4.88	5.69	5.29	6.87	-0.159462949812286	3.04172828564692	0.315508046441576	0.695383767840782	4:124479-163989:+	ZNF718	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 718 [Source:HGNC Symbol%3BAcc:HGNC:26889]
ENSG00000170270	57.03	54.91	62.63	51.15	54.64	58.74	0.0996999865341676	4.20011297107508	0.315595355500003	0.695452715750317	14:93202893-93207094:-	GON7	3;GO:0000408,cellular_component EKC/KEOPS complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	GON7%2C KEOPS complex subunit homolog [Source:HGNC Symbol%3BAcc:HGNC:20356]
ENSG00000204560	16.49	16.40	16.46	16.33	16.10	15.05	0.0681957710872019	5.71793289783695	0.315743752080472	0.695600334379077	6:30653118-30673037:-	DHX16	17;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity	DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [EC:3.6.4.13]; K12813	DEAH-box helicase 16 [Source:HGNC Symbol%3BAcc:HGNC:2739]
ENSG00000111142	53.06	52.68	52.98	56.68	55.67	54.81	-0.0626862397990904	6.40851367271818	0.31581080153101	0.695600334379077	12:95473519-95515839:+	METAP2	16;GO:0003723,molecular_function RNA binding;GO:0004177,molecular_function aminopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0018206,biological_process peptidyl-methionine modification;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0031365,biological_process N-terminal protein amino acid modification;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070084,biological_process protein initiator methionine removal	NA	methionyl aminopeptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:16672]
ENSG00000158863	10.67	9.50	11.88	10.41	9.17	10.62	0.102551789309542	4.60451855717739	0.315830458757793	0.695600334379077	8:22089158-22104898:+	FAM160B2	NA	NA	family with sequence similarity 160 member B2 [Source:HGNC Symbol%3BAcc:HGNC:16492]
ENSG00000119714	1.74	1.05	1.48	1.98	1.52	1.80	-0.271781407342904	0.943920855400043	0.31588836560336	0.695604449571494	14:91232531-91253925:-	GPR68	14;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032024,biological_process positive regulation of insulin secretion;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045656,biological_process negative regulation of monocyte differentiation;GO:0071467,biological_process cellular response to pH;GO:2001206,biological_process positive regulation of osteoclast development	NA	G protein-coupled receptor 68 [Source:HGNC Symbol%3BAcc:HGNC:4519]
ENSG00000105568	121.21	133.82	117.67	115.65	129.53	111.15	0.0758757788726986	7.96257150790859	0.316172779203153	0.696107255808573	19:52190038-52229533:+	PPP2R1A	49;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000188,biological_process inactivation of MAPK activity;GO:0000775,cellular_component chromosome, centromeric region;GO:0003823,molecular_function antigen binding;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006275,biological_process regulation of DNA replication;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006461,biological_process protein complex assembly;GO:0006470,biological_process protein dephosphorylation;GO:0006672,biological_process ceramide metabolic process;GO:0006915,biological_process apoptotic process;GO:0007059,biological_process chromosome segregation;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0007143,biological_process female meiotic division;GO:0008380,biological_process RNA splicing;GO:0010033,biological_process response to organic substance;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0019932,biological_process second-messenger-mediated signaling;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030155,biological_process regulation of cell adhesion;GO:0030308,biological_process negative regulation of cell growth;GO:0030425,cellular_component dendrite;GO:0040008,biological_process regulation of growth;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0042995,cellular_component cell projection;GO:0045595,biological_process regulation of cell differentiation;GO:0046982,molecular_function protein heterodimerization activity;GO:0050790,biological_process regulation of catalytic activity;GO:0051232,biological_process meiotic spindle elongation;GO:0051306,biological_process mitotic sister chromatid separation;GO:0051754,biological_process meiotic sister chromatid cohesion, centromeric;GO:0070062,cellular_component extracellular exosome;GO:0070262,biological_process peptidyl-serine dephosphorylation;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1903538,biological_process regulation of meiotic cell cycle process involved in oocyte maturation;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A; K03456	protein phosphatase 2 scaffold subunit Aalpha [Source:HGNC Symbol%3BAcc:HGNC:9302]
ENSG00000150756	23.21	22.86	22.05	21.48	22.29	20.74	0.0910322976993203	4.26152909324199	0.316277744054652	0.69621486734357	5:10226329-10249897:-	FAM173B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 173 member B [Source:HGNC Symbol%3BAcc:HGNC:27029]
ENSG00000138411	0.57	0.53	0.75	0.64	0.58	0.36	0.258672706732294	1.50490735367132	0.316345948236149	0.696241534655199	2:196194369-196593692:-	HECW2	12;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0072686,cellular_component mitotic spindle	NA	HECT%2C C2 and WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:29853]
ENSG00000273611	58.27	53.07	59.31	60.81	62.09	58.69	-0.0727497463606112	5.20160220099856	0.316539822084726	0.69636008891266	17:36486628-36499310:+	ZNHIT3	5;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046966,molecular_function thyroid hormone receptor binding	NA	zinc finger HIT-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:12309]
ENSG00000111711	61.14	65.48	52.99	57.19	53.20	58.76	0.0919860357766625	4.65647918208982	0.316601318654317	0.69636008891266	12:21501780-21518408:+	GOLT1B	11;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling	NA	golgi transport 1B [Source:HGNC Symbol%3BAcc:HGNC:20175]
ENSG00000170606	69.93	75.30	66.17	70.76	76.41	76.28	-0.0691992039528521	7.52987980078239	0.316612722550688	0.69636008891266	5:133051961-133106449:+	HSPA4	9;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006986,biological_process response to unfolded protein;GO:0045040,biological_process protein import into mitochondrial outer membrane;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0070062,cellular_component extracellular exosome	HSPA4; heat shock 70kDa protein 4; K09489	heat shock protein family A (Hsp70) member 4 [Source:HGNC Symbol%3BAcc:HGNC:5237]
ENSG00000111790	33.60	28.98	31.94	34.16	35.69	31.80	-0.0857943375844973	4.65705582223398	0.316624211860392	0.69636008891266	12:26938382-26966650:+	FGFR1OP2	8;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009611,biological_process response to wounding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0042060,biological_process wound healing;GO:0042803,molecular_function protein homodimerization activity	NA	FGFR1 oncogene partner 2 [Source:HGNC Symbol%3BAcc:HGNC:23098]
ENSG00000130818	9.05	7.19	8.68	9.51	8.72	9.05	-0.10724862856838	3.87624935809626	0.31680259656748	0.69662898692509	19:9523223-9538645:-	ZNF426	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 426 [Source:HGNC Symbol%3BAcc:HGNC:20725]
ENSG00000182318	1.87	1.43	2.20	1.37	1.49	1.81	0.259160391925895	1.41732835345835	0.317057082260511	0.697052460979344	19:58327018-58342332:+	ZSCAN22	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 22 [Source:HGNC Symbol%3BAcc:HGNC:4929]
ENSG00000101333	33.03	34.84	30.17	32.61	38.82	33.12	-0.0820573377770991	6.93470174463376	0.317137373857961	0.697052460979344	20:9068762-9481242:+	PLCB4	19;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007268,biological_process chemical synaptic transmission;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0014069,cellular_component postsynaptic density;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030425,cellular_component dendrite;GO:0035556,biological_process intracellular signal transduction;GO:0043647,biological_process inositol phosphate metabolic process	PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]; K05858	phospholipase C beta 4 [Source:HGNC Symbol%3BAcc:HGNC:9059]
ENSG00000182195	47.89	49.75	47.72	45.98	44.33	47.52	0.0849788716645805	4.37960996189598	0.317242092989621	0.697052460979344	X:141175744-141177125:-	LDOC1	7;GO:0001893,biological_process maternal placenta development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008285,biological_process negative regulation of cell proliferation;GO:0060137,biological_process maternal process involved in parturition;GO:1903547,biological_process regulation of growth hormone activity	NA	LDOC1%2C regulator of NFKB signaling [Source:HGNC Symbol%3BAcc:HGNC:6548]
ENSG00000135211	88.33	95.81	73.60	77.87	83.45	81.60	0.0919385585086613	5.06086900674901	0.317319432171565	0.697052460979344	7:77793727-77798580:-	TMEM60	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 60 [Source:HGNC Symbol%3BAcc:HGNC:21754]
ENSG00000144445	12.10	14.06	13.67	12.05	13.65	12.16	0.0819660730914085	5.33356163574397	0.317319897176316	0.697052460979344	2:210021422-210171383:-	KANSL1L	1;GO:0000123,cellular_component histone acetyltransferase complex	NA	KAT8 regulatory NSL complex subunit 1 like [Source:HGNC Symbol%3BAcc:HGNC:26310]
ENSG00000111145	14.00	15.42	12.42	15.88	12.73	17.28	-0.129069748490636	4.17007895630314	0.317332108031441	0.697052460979344	12:96194381-96269835:+	ELK3	22;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0030154,biological_process cell differentiation;GO:0032422,molecular_function purine-rich negative regulatory element binding;GO:0042060,biological_process wound healing;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	ELK3%2C ETS transcription factor [Source:HGNC Symbol%3BAcc:HGNC:3325]
ENSG00000119514	5.63	5.48	6.38	5.41	4.61	6.01	0.138238834042034	3.30926921372821	0.317412045854822	0.697104693063677	9:98807698-98850081:+	GALNT12	11;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 12 [Source:HGNC Symbol%3BAcc:HGNC:19877]
ENSG00000244187	385.17	395.24	389.36	381.75	369.85	378.50	0.0609939611475072	6.95889699476426	0.317512339802449	0.697162399643398	9:136791354-136793257:+	TMEM141	5;GO:0003341,biological_process cilium movement;GO:0005930,cellular_component axoneme;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036158,biological_process outer dynein arm assembly	NA	transmembrane protein 141 [Source:HGNC Symbol%3BAcc:HGNC:28211]
ENSG00000188467	16.20	16.24	17.87	18.56	18.17	17.07	-0.0825192095108825	4.77333138783886	0.317550649124609	0.697162399643398	15:48120971-48142672:+	SLC24A5	27;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0008273,molecular_function calcium, potassium:sodium antiporter activity;GO:0015293,molecular_function symporter activity;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030955,molecular_function potassium ion binding;GO:0031402,molecular_function sodium ion binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034220,biological_process ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042470,cellular_component melanosome;GO:0048021,biological_process regulation of melanin biosynthetic process;GO:0048022,biological_process negative regulation of melanin biosynthetic process;GO:0050896,biological_process response to stimulus;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport	NA	solute carrier family 24 member 5 [Source:HGNC Symbol%3BAcc:HGNC:20611]
ENSG00000156265	1.67	3.38	1.22	3.00	3.22	1.74	-0.372044068517843	1.08331039673626	0.31789291310799	0.697790403255435	21:29077470-29175889:+	MAP3K7CL	6;GO:0000165,biological_process MAPK cascade;GO:0000186,biological_process activation of MAPKK activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol	NA	MAP3K7 C-terminal like [Source:HGNC Symbol%3BAcc:HGNC:16457]
ENSG00000136003	47.08	54.18	52.11	49.49	48.94	47.78	0.0764226025619067	5.13598798138912	0.31811843252627	0.698161970111138	12:108562581-108569384:+	ISCU	18;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008198,molecular_function ferrous iron binding;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0032947,molecular_function protein complex scaffold;GO:0036455,molecular_function iron-sulfur transferase activity;GO:0044281,biological_process small molecule metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0097428,biological_process protein maturation by iron-sulfur cluster transfer	NA	iron-sulfur cluster assembly enzyme [Source:HGNC Symbol%3BAcc:HGNC:29882]
ENSG00000011260	40.19	36.73	35.03	41.21	37.30	40.17	-0.0718342621061699	6.13631654572746	0.318326794403082	0.698495757278674	17:51260527-51297936:+	UTP18	11;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0032040,cellular_component small-subunit processome;GO:0034388,cellular_component Pwp2p-containing subcomplex of 90S preribosome	UTP18; U3 small nucleolar RNA-associated protein 18; K14553	UTP18%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:24274]
ENSG00000155542	4.31	7.70	4.65	4.08	5.62	4.44	0.226898276009508	2.25643141640751	0.318490516915489	0.698731492837039	5:56909259-56925532:+	SETD9	6;GO:0005654,cellular_component nucleoplasm;GO:0008168,molecular_function methyltransferase activity;GO:0016278,molecular_function lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	SET domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:28508]
ENSG00000118363	102.96	105.76	96.17	95.50	101.04	96.80	0.0661697453894835	6.49018042238288	0.318628605342702	0.698910916790768	11:74949246-74979031:+	SPCS2	12;GO:0005783,cellular_component endoplasmic reticulum;GO:0005787,cellular_component signal peptidase complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045047,biological_process protein targeting to ER	SPCS2, SPC2; signal peptidase complex subunit 2 [EC:3.4.-.-]; K12947	signal peptidase complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:28962]
ENSG00000126215	12.73	12.19	12.86	15.57	11.78	14.04	-0.118371002467745	3.85434928413989	0.318768305240146	0.698984648917619	14:103697608-103715504:-	XRCC3	39;GO:0000150,molecular_function recombinase activity;GO:0000166,molecular_function nucleotide binding;GO:0000400,molecular_function four-way junction DNA binding;GO:0000707,biological_process meiotic DNA recombinase assembly;GO:0000722,biological_process telomere maintenance via recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007131,biological_process reciprocal meiotic recombination;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0010033,biological_process response to organic substance;GO:0010212,biological_process response to ionizing radiation;GO:0010824,biological_process regulation of centrosome duplication;GO:0033063,cellular_component Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0033065,cellular_component Rad51C-XRCC3 complex;GO:0036297,biological_process interstrand cross-link repair;GO:0042148,biological_process strand invasion;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071140,biological_process resolution of mitotic recombination intermediates;GO:0090267,biological_process positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0090656,biological_process t-circle formation;GO:0090657,biological_process telomeric loop disassembly;GO:0090737,biological_process telomere maintenance via telomere trimming	XRCC3; DNA-repair protein XRCC3; K10880	X-ray repair cross complementing 3 [Source:HGNC Symbol%3BAcc:HGNC:12830]
ENSG00000185515	14.68	17.79	15.30	15.86	20.10	16.21	-0.121587203398627	4.08909190403322	0.318774840693035	0.698984648917619	X:155071419-155123074:+	BRCC3	36;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000152,cellular_component nuclear ubiquitin ligase complex;GO:0000922,cellular_component spindle pole;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006508,biological_process proteolysis;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0010165,biological_process response to X-ray;GO:0010212,biological_process response to ionizing radiation;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030234,molecular_function enzyme regulator activity;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031593,molecular_function polyubiquitin binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0045739,biological_process positive regulation of DNA repair;GO:0046872,molecular_function metal ion binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051301,biological_process cell division;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070531,cellular_component BRCA1-A complex;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070537,biological_process histone H2A K63-linked deubiquitination;GO:0070552,cellular_component BRISC complex	BRCC3, BRCC36; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]; K11864	BRCA1/BRCA2-containing complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:24185]
ENSG00000099958	1.42	1.31	1.32	0.95	1.12	1.12	0.35864491412903	0.369761913954141	0.318860450398919	0.698988501798963	22:23834502-23839128:-	DERL3	13;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005785,cellular_component signal recognition particle receptor complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0048500,cellular_component signal recognition particle;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol	DERL2_3; Derlin-2/3; K13989	derlin 3 [Source:HGNC Symbol%3BAcc:HGNC:14236]
ENSG00000038945	2.41	2.51	3.53	3.00	2.14	2.17	0.227524537210646	2.05497822893146	0.318956858836884	0.698988501798963	8:16107877-16567490:-	MSR1	24;GO:0001540,molecular_function beta-amyloid binding;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0005581,cellular_component collagen trimer;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006911,biological_process phagocytosis, engulfment;GO:0010629,biological_process negative regulation of gene expression;GO:0010744,biological_process positive regulation of macrophage derived foam cell differentiation;GO:0010886,biological_process positive regulation of cholesterol storage;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030301,biological_process cholesterol transport;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034362,cellular_component low-density lipoprotein particle;GO:0034381,biological_process plasma lipoprotein particle clearance;GO:0042953,biological_process lipoprotein transport;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0097242,biological_process beta-amyloid clearance	MSR1, CD204; macrophage scavenger receptor 1; K06558	macrophage scavenger receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:7376]
ENSG00000090905	15.60	15.62	15.79	16.17	16.70	16.62	-0.0624085677060427	6.59897937371498	0.319020985765012	0.698988501798963	16:24610208-24827632:+	TNRC6A	20;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0031047,biological_process gene silencing by RNA;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035194,biological_process posttranscriptional gene silencing by RNA;GO:0035195,biological_process gene silencing by miRNA;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0060964,biological_process regulation of gene silencing by miRNA	NA	trinucleotide repeat containing 6A [Source:HGNC Symbol%3BAcc:HGNC:11969]
ENSG00000136146	23.54	27.16	23.54	23.37	24.26	22.56	0.0861763770469652	4.64832071421561	0.319063494466693	0.698988501798963	13:48053322-48095131:-	MED4	20;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003712,molecular_function transcription cofactor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016592,cellular_component mediator complex;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0070847,cellular_component core mediator complex	MED4; mediator of RNA polymerase II transcription subunit 4; K15146	mediator complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:17903]
ENSG00000147162	262.25	228.77	284.58	248.43	230.02	261.22	0.0805100938003411	9.63169182421705	0.31918302523406	0.698988501798963	X:71533082-71575897:+	OGT	42;GO:0000123,cellular_component histone acetyltransferase complex;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006110,biological_process regulation of glycolytic process;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007584,biological_process response to nutrient;GO:0008289,molecular_function lipid binding;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016262,molecular_function protein N-acetylglucosaminyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032868,biological_process response to insulin;GO:0032922,biological_process circadian regulation of gene expression;GO:0035020,biological_process regulation of Rac protein signal transduction;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0045862,biological_process positive regulation of proteolysis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific);GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048511,biological_process rhythmic process;GO:0061087,biological_process positive regulation of histone H3-K27 methylation;GO:0080182,biological_process histone H3-K4 trimethylation;GO:0090526,biological_process regulation of gluconeogenesis involved in cellular glucose homeostasis;GO:0097363,molecular_function protein O-GlcNAc transferase activity	OGT; protein O-GlcNAc transferase [EC:2.4.1.255]; K09667	O-linked N-acetylglucosamine (GlcNAc) transferase [Source:HGNC Symbol%3BAcc:HGNC:8127]
ENSG00000015475	37.27	37.19	38.50	37.00	35.56	35.65	0.0745869486085258	5.00391757992598	0.31925025699267	0.698988501798963	22:17734137-17774770:-	BID	46;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007420,biological_process brain development;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0010918,biological_process positive regulation of mitochondrial membrane potential;GO:0016020,cellular_component membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032355,biological_process response to estradiol;GO:0032459,biological_process regulation of protein oligomerization;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0032592,cellular_component integral component of mitochondrial membrane;GO:0034349,biological_process glial cell apoptotic process;GO:0042127,biological_process regulation of cell proliferation;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0042775,biological_process mitochondrial ATP synthesis coupled electron transport;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0051260,biological_process protein homooligomerization;GO:0051402,biological_process neuron apoptotic process;GO:0070062,cellular_component extracellular exosome;GO:0090150,biological_process establishment of protein localization to membrane;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097284,biological_process hepatocyte apoptotic process;GO:0097345,biological_process mitochondrial outer membrane permeabilization;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1902108,biological_process regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle;GO:2000271,biological_process positive regulation of fibroblast apoptotic process;GO:2001235,biological_process positive regulation of apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BID; BH3 interacting domain death agonist; K04726	BH3 interacting domain death agonist [Source:HGNC Symbol%3BAcc:HGNC:1050]
ENSG00000081870	85.09	85.18	76.67	87.93	87.64	85.25	-0.0684488045107889	6.06862719044875	0.319262504076103	0.698988501798963	1:53916573-53945929:-	HSPB11	17;GO:0001501,biological_process skeletal system development;GO:0005515,molecular_function protein binding;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007224,biological_process smoothened signaling pathway;GO:0007507,biological_process heart development;GO:0015031,biological_process protein transport;GO:0030324,biological_process lung development;GO:0030992,cellular_component intraciliary transport particle B;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070986,biological_process left/right axis specification;GO:0097542,cellular_component ciliary tip	NA	heat shock protein family B (small) member 11 [Source:HGNC Symbol%3BAcc:HGNC:25019]
ENSG00000257315	5.33	4.74	5.66	5.48	5.31	6.11	-0.0871751727115971	4.87960278608032	0.319262904177718	0.698988501798963	1:203795713-203854999:+	ZBED6	12;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity	NA	zinc finger BED-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:33273]
ENSG00000100483	12.34	11.41	15.43	11.12	12.25	12.49	0.147131508167423	3.13286124563446	0.31941013317324	0.698988501798963	14:50108631-50116600:-	VCPKMT	14;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0018023,biological_process peptidyl-lysine trimethylation;GO:0032259,biological_process methylation;GO:0032780,biological_process negative regulation of ATPase activity;GO:0043234,cellular_component protein complex;GO:0051117,molecular_function ATPase binding	NA	valosin containing protein lysine methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:20352]
ENSG00000196839	10.25	7.20	8.45	8.04	7.31	8.33	0.152338823413901	3.20243124172944	0.319578328698093	0.698988501798963	20:44619521-44652233:-	ADA	72;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001821,biological_process histamine secretion;GO:0001829,biological_process trophectodermal cell differentiation;GO:0001883,molecular_function purine nucleoside binding;GO:0001889,biological_process liver development;GO:0001890,biological_process placenta development;GO:0002314,biological_process germinal center B cell differentiation;GO:0002636,biological_process positive regulation of germinal center formation;GO:0002686,biological_process negative regulation of leukocyte migration;GO:0002906,biological_process negative regulation of mature B cell apoptotic process;GO:0004000,molecular_function adenosine deaminase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006154,biological_process adenosine catabolic process;GO:0006157,biological_process deoxyadenosine catabolic process;GO:0007155,biological_process cell adhesion;GO:0007568,biological_process aging;GO:0008270,molecular_function zinc ion binding;GO:0009117,biological_process nucleotide metabolic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010460,biological_process positive regulation of heart rate;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019239,molecular_function deaminase activity;GO:0030054,cellular_component cell junction;GO:0030324,biological_process lung development;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032261,biological_process purine nucleotide salvage;GO:0032839,cellular_component dendrite cytoplasm;GO:0033089,biological_process positive regulation of T cell differentiation in thymus;GO:0033197,biological_process response to vitamin E;GO:0033632,biological_process regulation of cell-cell adhesion mediated by integrin;GO:0042110,biological_process T cell activation;GO:0042323,biological_process negative regulation of circadian sleep/wake cycle, non-REM sleep;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043101,biological_process purine-containing compound salvage;GO:0043103,biological_process hypoxanthine salvage;GO:0043278,biological_process response to morphine;GO:0045187,biological_process regulation of circadian sleep/wake cycle, sleep;GO:0045580,biological_process regulation of T cell differentiation;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046061,biological_process dATP catabolic process;GO:0046085,biological_process adenosine metabolic process;GO:0046101,biological_process hypoxanthine biosynthetic process;GO:0046103,biological_process inosine biosynthetic process;GO:0046111,biological_process xanthine biosynthetic process;GO:0046638,biological_process positive regulation of alpha-beta T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048286,biological_process lung alveolus development;GO:0048541,biological_process Peyer's patch development;GO:0048566,biological_process embryonic digestive tract development;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050850,biological_process positive regulation of calcium-mediated signaling;GO:0050862,biological_process positive regulation of T cell receptor signaling pathway;GO:0050870,biological_process positive regulation of T cell activation;GO:0060169,biological_process negative regulation of adenosine receptor signaling pathway;GO:0060205,cellular_component cytoplasmic membrane-bounded vesicle lumen;GO:0060407,biological_process negative regulation of penile erection;GO:0070244,biological_process negative regulation of thymocyte apoptotic process;GO:0070256,biological_process negative regulation of mucus secretion	add, ADA; adenosine deaminase [EC:3.5.4.4]; K01488	adenosine deaminase [Source:HGNC Symbol%3BAcc:HGNC:186]
ENSG00000181274	2.12	2.73	2.42	2.89	3.04	2.92	-0.284093866925896	1.01939205623386	0.319606063373762	0.698988501798963	10:97332496-97334709:-	FRAT2	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0016055,biological_process Wnt signaling pathway;GO:1904886,biological_process beta-catenin destruction complex disassembly	FRAT2; frequently rearranged in advanced T-cell lymphomas 2; K03096	FRAT2%2C WNT signaling pathway regulator [Source:HGNC Symbol%3BAcc:HGNC:16048]
ENSG00000127586	5.25	5.69	5.28	5.00	5.03	5.32	0.0856532132639032	4.34831391958046	0.319650528659806	0.698988501798963	16:788045-800737:+	CHTF18	14;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:1900264,biological_process positive regulation of DNA-directed DNA polymerase activity	NA	chromosome transmission fidelity factor 18 [Source:HGNC Symbol%3BAcc:HGNC:18435]
ENSG00000102901	18.89	18.18	18.59	15.74	18.42	18.81	0.0838860775339849	4.99374504597972	0.319674007875555	0.698988501798963	16:67828156-67847811:-	CENPT	22;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000788,cellular_component nuclear nucleosome;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0016604,cellular_component nuclear body;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0042393,molecular_function histone binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0051382,biological_process kinetochore assembly;GO:1903394,biological_process protein localization to kinetochore involved in kinetochore assembly	NA	centromere protein T [Source:HGNC Symbol%3BAcc:HGNC:25787]
ENSG00000149646	0.24	0.41	0.46	0.39	0.58	0.50	-0.422201745521445	0.0723587188752478	0.319715656924183	0.698988501798963	20:35954563-36030700:+	CNBD2	5;GO:0000166,molecular_function nucleotide binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007283,biological_process spermatogenesis;GO:0030552,molecular_function cAMP binding	NA	cyclic nucleotide binding domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:16145]
ENSG00000140326	5.30	5.31	4.63	4.87	5.24	4.10	0.112338311746199	4.19392023488203	0.319766040533035	0.698988501798963	15:42723558-42737126:-	CDAN1	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006325,biological_process chromatin organization;GO:0008104,biological_process protein localization;GO:0008156,biological_process negative regulation of DNA replication;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031497,biological_process chromatin assembly	NA	codanin 1 [Source:HGNC Symbol%3BAcc:HGNC:1713]
ENSG00000088833	56.85	52.48	51.46	56.53	53.97	59.59	-0.0686516406966422	6.05340047425516	0.319790698108292	0.698988501798963	20:1442161-1473842:-	NSFL1C	21;GO:0000045,biological_process autophagosome assembly;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007030,biological_process Golgi organization;GO:0008289,molecular_function lipid binding;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0031468,biological_process nuclear envelope reassembly;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0050790,biological_process regulation of catalytic activity;GO:0051117,molecular_function ATPase binding;GO:0061025,biological_process membrane fusion;GO:1990730,cellular_component VCP-NSFL1C complex	SHP1, UBX1, NSFL1C; UBX domain-containing protein 1; K14012	NSFL1 cofactor [Source:HGNC Symbol%3BAcc:HGNC:15912]
ENSG00000148158	5.79	4.82	7.03	6.65	7.42	5.87	-0.150555242131208	3.09187501523825	0.319834500397511	0.698988501798963	9:112750837-112881671:+	SNX30	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0015031,biological_process protein transport;GO:0016050,biological_process vesicle organization;GO:0019898,cellular_component extrinsic component of membrane;GO:0035091,molecular_function phosphatidylinositol binding	NA	sorting nexin family member 30 [Source:HGNC Symbol%3BAcc:HGNC:23685]
ENSG00000266028	20.63	20.82	20.27	19.42	19.92	20.22	0.0622378270725966	6.06366891797947	0.319841566586371	0.698988501798963	1:206203344-206464443:+	SRGAP2	18;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0014069,cellular_component postsynaptic density;GO:0021816,biological_process extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration;GO:0042803,molecular_function protein homodimerization activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045211,cellular_component postsynaptic membrane;GO:0045335,cellular_component phagocytic vesicle;GO:0046847,biological_process filopodium assembly;GO:0048365,molecular_function Rac GTPase binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0060996,biological_process dendritic spine development	SRGAP; SLIT-ROBO Rho GTPase activating protein; K07526	SLIT-ROBO Rho GTPase activating protein 2 [Source:HGNC Symbol%3BAcc:HGNC:19751]
ENSG00000118518	34.34	33.05	35.79	34.79	35.62	39.16	-0.0736154120332667	5.42234629830916	0.319847741530895	0.698988501798963	6:127266609-127288567:+	RNF146	19;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008270,molecular_function zinc ion binding;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0072572,molecular_function poly-ADP-D-ribose binding;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	ring finger protein 146 [Source:HGNC Symbol%3BAcc:HGNC:21336]
ENSG00000102054	123.61	138.88	119.78	133.66	140.64	130.40	-0.0716509189939404	7.69013395036502	0.319908523493851	0.698988501798963	X:16839282-16870414:-	RBBP7	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003723,molecular_function RNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016581,cellular_component NuRD complex;GO:0030308,biological_process negative regulation of cell growth;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0035098,cellular_component ESC/E(Z) complex;GO:0043687,biological_process post-translational protein modification;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048545,biological_process response to steroid hormone;GO:0070370,biological_process cellular heat acclimation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	RB binding protein 7%2C chromatin remodeling factor [Source:HGNC Symbol%3BAcc:HGNC:9890]
ENSG00000109320	17.69	17.31	18.70	20.29	18.61	18.04	-0.0708103107373123	5.77556592938184	0.319959128914985	0.698988501798963	4:102501328-102617302:+	NFKB1	70;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000975,molecular_function regulatory region DNA binding;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001818,biological_process negative regulation of cytokine production;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0008134,molecular_function transcription factor binding;GO:0010629,biological_process negative regulation of gene expression;GO:0010744,biological_process positive regulation of macrophage derived foam cell differentiation;GO:0010884,biological_process positive regulation of lipid storage;GO:0010956,biological_process negative regulation of calcidiol 1-monooxygenase activity;GO:0010957,biological_process negative regulation of vitamin D biosynthetic process;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0032269,biological_process negative regulation of cellular protein metabolic process;GO:0032375,biological_process negative regulation of cholesterol transport;GO:0032481,biological_process positive regulation of type I interferon production;GO:0033256,cellular_component I-kappaB/NF-kappaB complex;GO:0034774,cellular_component secretory granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0035994,biological_process response to muscle stretch;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042805,molecular_function actinin binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045083,biological_process negative regulation of interleukin-12 biosynthetic process;GO:0045087,biological_process innate immune response;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071316,biological_process cellular response to nicotine;GO:0071347,biological_process cellular response to interleukin-1;GO:0071354,biological_process cellular response to interleukin-6;GO:0071359,biological_process cellular response to dsRNA;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1900127,biological_process positive regulation of hyaluronan biosynthetic process;GO:2000630,biological_process positive regulation of miRNA metabolic process	NFKB1; nuclear factor NF-kappa-B p105 subunit; K02580	nuclear factor kappa B subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:7794]
ENSG00000171792	47.38	51.68	50.29	49.81	55.81	53.01	-0.0779942023348324	5.2198111398911	0.320070892986348	0.699091094836945	12:2876257-2889523:+	RHNO1	13;GO:0000077,biological_process DNA damage checkpoint;GO:0000725,biological_process recombinational repair;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006260,biological_process DNA replication;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0034644,biological_process cellular response to UV;GO:0070318,biological_process positive regulation of G0 to G1 transition;GO:0071479,biological_process cellular response to ionizing radiation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	RAD9-HUS1-RAD1 interacting nuclear orphan 1 [Source:HGNC Symbol%3BAcc:HGNC:28206]
ENSG00000164715	7.33	8.20	7.72	9.07	7.55	8.22	-0.0870698975714194	5.18144044737167	0.320164112464132	0.699091094836945	7:98106884-98209633:+	LMTK2	28;GO:0000166,molecular_function nucleotide binding;GO:0001881,biological_process receptor recycling;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030426,cellular_component growth cone;GO:0032456,biological_process endocytic recycling;GO:0033572,biological_process transferrin transport;GO:0043025,cellular_component neuronal cell body;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045022,biological_process early endosome to late endosome transport;GO:0046777,biological_process protein autophosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0070853,molecular_function myosin VI binding	NA	lemur tyrosine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:17880]
ENSG00000019582	26.14	27.04	30.38	29.61	30.84	28.95	-0.0840389066586879	4.83865708568093	0.320175048267786	0.699091094836945	5:150401636-150412929:-	CD74	85;GO:0000139,cellular_component Golgi membrane;GO:0000187,biological_process activation of MAPK activity;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0001540,molecular_function beta-amyloid binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001961,biological_process positive regulation of cytokine-mediated signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002606,biological_process positive regulation of dendritic cell antigen processing and presentation;GO:0002792,biological_process negative regulation of peptide secretion;GO:0002830,biological_process positive regulation of type 2 immune response;GO:0002906,biological_process negative regulation of mature B cell apoptotic process;GO:0004896,molecular_function cytokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005773,cellular_component vacuole;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006886,biological_process intracellular protein transport;GO:0006952,biological_process defense response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016064,biological_process immunoglobulin mediated immune response;GO:0019882,biological_process antigen processing and presentation;GO:0019883,biological_process antigen processing and presentation of endogenous antigen;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019955,molecular_function cytokine binding;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030658,cellular_component transport vesicle membrane;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0032588,cellular_component trans-Golgi network membrane;GO:0033674,biological_process positive regulation of kinase activity;GO:0035691,biological_process macrophage migration inhibitory factor signaling pathway;GO:0035692,cellular_component macrophage migration inhibitory factor receptor complex;GO:0035693,cellular_component NOS2-CD74 complex;GO:0035718,molecular_function macrophage migration inhibitory factor binding;GO:0042289,molecular_function MHC class II protein binding;GO:0042609,molecular_function CD4 receptor binding;GO:0042613,cellular_component MHC class II protein complex;GO:0042658,molecular_function MHC class II protein binding, via antigen binding groove;GO:0042802,molecular_function identical protein binding;GO:0043030,biological_process regulation of macrophage activation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043202,cellular_component lysosomal lumen;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044183,molecular_function protein binding involved in protein folding;GO:0045058,biological_process T cell selection;GO:0045059,biological_process positive thymic T cell selection;GO:0045060,biological_process negative thymic T cell selection;GO:0045581,biological_process negative regulation of T cell differentiation;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0045657,biological_process positive regulation of monocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046598,biological_process positive regulation of viral entry into host cell;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050900,biological_process leukocyte migration;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051290,biological_process protein heterotetramerization;GO:0060907,biological_process positive regulation of macrophage cytokine production;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000343,biological_process positive regulation of chemokine (C-X-C motif) ligand 2 production	CD74, DHLAG; CD74 antigen; K06505	CD74 molecule [Source:HGNC Symbol%3BAcc:HGNC:1697]
ENSG00000119650	34.32	36.57	32.48	36.65	36.41	36.81	-0.0809427323044455	4.92718010811298	0.320376673592123	0.699211900392889	14:75902135-76084585:+	IFT43	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0030991,cellular_component intraciliary transport particle A;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip	NA	intraflagellar transport 43 [Source:HGNC Symbol%3BAcc:HGNC:29669]
ENSG00000099364	17.67	16.82	16.26	15.80	16.97	15.83	0.0754548119430193	5.13619260400748	0.320480572774058	0.699211900392889	16:30923054-30948783:+	FBXL19	10;GO:0000209,biological_process protein polyubiquitination;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	F-box and leucine rich repeat protein 19 [Source:HGNC Symbol%3BAcc:HGNC:25300]
ENSG00000008382	7.03	8.38	7.45	7.54	6.86	6.84	0.108874106809712	3.71148510606434	0.320484678967926	0.699211900392889	19:4343526-4360086:+	MPND	3;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity	NA	MPN domain containing [Source:HGNC Symbol%3BAcc:HGNC:25934]
ENSG00000136603	13.80	9.69	12.16	13.06	12.05	13.84	-0.107898539701734	4.69009838457566	0.32052512710774	0.699211900392889	3:170357677-170396835:+	SKIL	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001669,cellular_component acrosomal vesicle;GO:0001825,biological_process blastocyst formation;GO:0002260,biological_process lymphocyte homeostasis;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007050,biological_process cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0034097,biological_process response to cytokine;GO:0043234,cellular_component protein complex;GO:0045596,biological_process negative regulation of cell differentiation;GO:0046332,molecular_function SMAD binding;GO:0048666,biological_process neuron development;GO:0050772,biological_process positive regulation of axonogenesis;GO:0070306,biological_process lens fiber cell differentiation;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902231,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	NA	SKI like proto-oncogene [Source:HGNC Symbol%3BAcc:HGNC:10897]
ENSG00000061273	18.45	18.05	19.88	17.98	17.56	18.76	0.0676310554626094	5.91577367540378	0.320556486840321	0.699211900392889	12:47782721-47833132:-	HDAC7	33;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001570,biological_process vasculogenesis;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007043,biological_process cell-cell junction assembly;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0033613,molecular_function activating transcription factor binding;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070491,molecular_function repressing transcription factor binding;GO:0070932,biological_process histone H3 deacetylation;GO:0071889,molecular_function 14-3-3 protein binding;GO:0090050,biological_process positive regulation of cell migration involved in sprouting angiogenesis;GO:1901223,biological_process negative regulation of NIK/NF-kappaB signaling	HDAC7; histone deacetylase 7 [EC:3.5.1.98]; K11408	histone deacetylase 7 [Source:HGNC Symbol%3BAcc:HGNC:14067]
ENSG00000165506	8.10	7.92	7.09	7.57	8.79	8.54	-0.0978517681827999	4.34068235765259	0.320598641421036	0.699211900392889	14:49625173-49635230:-	DNAAF2	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0060285,biological_process cilium-dependent cell motility;GO:0070286,biological_process axonemal dynein complex assembly	NA	dynein axonemal assembly factor 2 [Source:HGNC Symbol%3BAcc:HGNC:20188]
ENSG00000102125	25.61	23.25	29.36	26.01	22.29	25.43	0.101781052076073	4.74196821884981	0.320624678726845	0.699211900392889	X:154411517-154421726:+	TAZ	26;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006644,biological_process phospholipid metabolic process;GO:0006936,biological_process muscle contraction;GO:0007507,biological_process heart development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008152,biological_process metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030097,biological_process hemopoiesis;GO:0031224,cellular_component intrinsic component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032049,biological_process cardiolipin biosynthetic process;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035965,biological_process cardiolipin acyl-chain remodeling;GO:0042407,biological_process cristae formation;GO:0042775,biological_process mitochondrial ATP synthesis coupled electron transport;GO:0047184,molecular_function 1-acylglycerophosphocholine O-acyltransferase activity;GO:0048738,biological_process cardiac muscle tissue development;GO:0060048,biological_process cardiac muscle contraction	TAZ; monolysocardiolipin acyltransferase [EC:2.3.1.-]; K13511	tafazzin [Source:HGNC Symbol%3BAcc:HGNC:11577]
ENSG00000106012	9.49	7.61	7.67	9.94	8.35	8.68	-0.105277075236795	4.47957939608917	0.320741225557879	0.699273471242403	7:2558971-2614734:+	IQCE	7;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005929,cellular_component cilium;GO:0019898,cellular_component extrinsic component of membrane;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060170,cellular_component ciliary membrane;GO:0098797,cellular_component plasma membrane protein complex	NA	IQ motif containing E [Source:HGNC Symbol%3BAcc:HGNC:29171]
ENSG00000155100	18.62	13.13	16.73	15.66	18.85	19.04	-0.121032945445565	4.09575154060173	0.320836298917942	0.699273471242403	8:91070195-91087095:+	OTUD6B	5;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	OTU domain containing 6B [Source:HGNC Symbol%3BAcc:HGNC:24281]
ENSG00000099917	25.52	25.35	24.91	24.57	24.75	23.85	0.0624624022336756	6.12328919228013	0.320849709775806	0.699273471242403	22:20495912-20587632:+	MED15	11;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016592,cellular_component mediator complex	NA	mediator complex subunit 15 [Source:HGNC Symbol%3BAcc:HGNC:14248]
ENSG00000136866	3.61	2.82	3.27	4.10	3.14	3.74	-0.155800682473005	2.77981735465427	0.320896303177136	0.699273471242403	9:113038379-113056759:-	ZFP37	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP37 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:12863]
ENSG00000169964	36.87	34.86	37.80	42.54	40.07	35.82	-0.0958265650181157	4.1943076522922	0.320934581943766	0.699273471242403	3:44861868-44865670:+	TMEM42	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 42 [Source:HGNC Symbol%3BAcc:HGNC:28444]
ENSG00000100330	12.78	11.67	14.03	12.10	12.25	12.47	0.0791935734814991	5.51305123804096	0.321073097869546	0.699398841659753	22:29883154-30030866:+	MTMR3	22;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0019898,cellular_component extrinsic component of membrane;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042149,biological_process cellular response to glucose starvation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0046872,molecular_function metal ion binding;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:1904562,biological_process phosphatidylinositol 5-phosphate metabolic process;GO:2000785,biological_process regulation of autophagosome assembly	NA	myotubularin related protein 3 [Source:HGNC Symbol%3BAcc:HGNC:7451]
ENSG00000140526	19.61	17.09	19.28	20.02	19.51	20.46	-0.0817788858564417	4.63651801489481	0.321104809362679	0.699398841659753	15:89087458-89202360:+	ABHD2	21;GO:0001669,cellular_component acrosomal vesicle;GO:0003707,molecular_function steroid hormone receptor activity;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007340,biological_process acrosome reaction;GO:0009611,biological_process response to wounding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030336,biological_process negative regulation of cell migration;GO:0032570,biological_process response to progesterone;GO:0036126,cellular_component sperm flagellum;GO:0042562,molecular_function hormone binding;GO:0042995,cellular_component cell projection;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0046464,biological_process acylglycerol catabolic process;GO:0047372,molecular_function acylglycerol lipase activity;GO:0048240,biological_process sperm capacitation;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0097524,cellular_component sperm plasma membrane	NA	abhydrolase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18717]
ENSG00000148399	17.08	15.01	15.58	15.85	14.65	14.73	0.0929664680350794	4.40461765907496	0.321195774034958	0.699445175182699	9:137554903-137578935:-	DPH7	3;GO:0016787,molecular_function hydrolase activity;GO:0017183,biological_process peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0061685,molecular_function diphthine methylesterase activity	NA	diphthamide biosynthesis 7 [Source:HGNC Symbol%3BAcc:HGNC:25199]
ENSG00000164111	889.31	966.83	840.94	832.35	925.82	829.10	0.071547974979845	9.74727463598402	0.321238777387945	0.699445175182699	4:121667954-121697113:-	ANXA5	22;GO:0002576,biological_process platelet degranulation;GO:0004859,molecular_function phospholipase inhibitor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0009897,cellular_component external side of plasma membrane;GO:0010033,biological_process response to organic substance;GO:0016020,cellular_component membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0050819,biological_process negative regulation of coagulation;GO:0070062,cellular_component extracellular exosome;GO:0072563,cellular_component endothelial microparticle	NA	annexin A5 [Source:HGNC Symbol%3BAcc:HGNC:543]
ENSG00000188766	0.36	0.73	0.61	0.81	0.48	0.94	-0.421935839276677	0.236515720804755	0.32132935888246	0.699519700422304	19:38388420-38399587:+	SPRED3	3;GO:0007275,biological_process multicellular organism development;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane	NA	sprouty related EVH1 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:31041]
ENSG00000103024	3.28	3.73	3.56	1.81	2.96	3.79	0.300165376241996	0.897107477158498	0.321442817626829	0.699643993547576	16:1770285-1771730:-	NME3	20;GO:0000166,molecular_function nucleotide binding;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006183,biological_process GTP biosynthetic process;GO:0006228,biological_process UTP biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0009117,biological_process nucleotide metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]; K00940	NME/NM23 nucleoside diphosphate kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:7851]
ENSG00000136942	1126.44	1112.95	1116.54	1205.01	1138.16	1176.66	-0.0570134294571919	8.96279412036646	0.321591332450661	0.699844531856601	9:124857879-124861981:-	RPL35	17;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L35e, RPL35; large subunit ribosomal protein L35e; K02918	ribosomal protein L35 [Source:HGNC Symbol%3BAcc:HGNC:10344]
ENSG00000240849	7.99	8.53	8.94	7.49	6.77	8.87	0.144581492873999	2.79799237569766	0.322006704619407	0.700580340753516	20:50118253-50153734:-	TMEM189	8;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0061630,molecular_function ubiquitin protein ligase activity	UBE2V; ubiquitin-conjugating enzyme E2 variant; K10704	transmembrane protein 189 [Source:HGNC Symbol%3BAcc:HGNC:16735]
ENSG00000174485	4.96	5.15	5.15	4.43	4.96	5.14	0.0810949630052057	4.84272691484584	0.322091281795282	0.700580340753516	15:65658045-65792293:-	DENND4A	9;GO:0003677,molecular_function DNA binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	DENN domain containing 4A [Source:HGNC Symbol%3BAcc:HGNC:24321]
ENSG00000249115	7.87	7.72	8.24	7.73	7.20	7.58	0.09556936065313	4.08742360974609	0.322098767798301	0.700580340753516	19:35612743-35625349:+	HAUS5	16;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:29130]
ENSG00000138709	13.36	13.30	13.60	13.42	12.84	12.39	0.0715248698451445	5.26811212677568	0.322357456336255	0.700966655754289	4:128061267-128222931:+	LARP1B	5;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	La ribonucleoprotein domain family member 1B [Source:HGNC Symbol%3BAcc:HGNC:24704]
ENSG00000099834	1.22	0.62	0.96	0.78	0.64	0.94	0.284327145546075	1.2804215672098	0.322389320688088	0.700966655754289	11:616564-626078:-	CDHR5	19;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008013,molecular_function beta-catenin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030154,biological_process cell differentiation;GO:0031526,cellular_component brush border membrane;GO:0031528,cellular_component microvillus membrane;GO:0032532,biological_process regulation of microvillus length;GO:0042995,cellular_component cell projection;GO:0044214,cellular_component spanning component of plasma membrane;GO:0050839,molecular_function cell adhesion molecule binding;GO:0070062,cellular_component extracellular exosome;GO:0090675,biological_process intermicrovillar adhesion	NA	cadherin related family member 5 [Source:HGNC Symbol%3BAcc:HGNC:7521]
ENSG00000188549	8.17	8.75	8.24	7.50	7.36	8.61	0.104831491805676	3.72740723556587	0.322623975397846	0.700987596545128	15:40331451-40340967:-	C15orf52	1;GO:0003723,molecular_function RNA binding	NA	chromosome 15 open reading frame 52 [Source:HGNC Symbol%3BAcc:HGNC:33488]
ENSG00000083457	6.09	7.32	5.95	6.69	5.51	5.88	0.10256886823079	4.46936272065995	0.322712005575298	0.700987596545128	17:3714627-3801243:-	ITGAE	9;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0046872,molecular_function metal ion binding	ITGAE, CD103; integrin alpha E; K06524	integrin subunit alpha E [Source:HGNC Symbol%3BAcc:HGNC:6147]
ENSG00000149600	67.57	57.31	64.26	66.20	62.94	72.67	-0.0779532971202053	5.55443672494033	0.322718984421581	0.700987596545128	20:32702690-32743997:-	COMMD7	12;GO:0005515,molecular_function protein binding;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051059,molecular_function NF-kappaB binding;GO:0070062,cellular_component extracellular exosome	NA	COMM domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:16223]
ENSG00000144567	51.46	51.04	53.90	47.52	52.24	50.94	0.0660368288331812	6.38522230323096	0.322732178916657	0.700987596545128	2:219176224-219185479:+	RETREG2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	reticulophagy regulator family member 2 [Source:HGNC Symbol%3BAcc:HGNC:28450]
ENSG00000160075	88.95	82.82	85.22	83.85	82.99	81.25	0.0645251113160217	6.10827932543557	0.322735775272449	0.700987596545128	1:1541672-1574869:-	SSU72	13;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0008420,molecular_function CTD phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0070940,biological_process dephosphorylation of RNA polymerase II C-terminal domain	NA	SSU72 homolog%2C RNA polymerase II CTD phosphatase [Source:HGNC Symbol%3BAcc:HGNC:25016]
ENSG00000111716	1121.91	1224.33	1045.99	1037.67	1168.37	1042.63	0.0740252034619683	10.1163181694882	0.322737784117893	0.700987596545128	12:21635341-21757857:-	LDHB	22;GO:0003824,molecular_function catalytic activity;GO:0004457,molecular_function lactate dehydrogenase activity;GO:0004459,molecular_function L-lactate dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006089,biological_process lactate metabolic process;GO:0006090,biological_process pyruvate metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019674,biological_process NAD metabolic process;GO:0019752,biological_process carboxylic acid metabolic process;GO:0019900,molecular_function kinase binding;GO:0042802,molecular_function identical protein binding;GO:0043209,cellular_component myelin sheath;GO:0045121,cellular_component membrane raft;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]; K00016	lactate dehydrogenase B [Source:HGNC Symbol%3BAcc:HGNC:6541]
ENSG00000030110	16.22	19.76	19.27	20.52	20.09	19.49	-0.116961064558778	3.66578190451155	0.32279839623678	0.700996587209089	6:33572546-33580293:-	BAK1	80;GO:0001776,biological_process leukocyte homeostasis;GO:0001782,biological_process B cell homeostasis;GO:0001783,biological_process B cell apoptotic process;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001974,biological_process blood vessel remodeling;GO:0002262,biological_process myeloid cell homeostasis;GO:0002352,biological_process B cell negative selection;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0007420,biological_process brain development;GO:0007568,biological_process aging;GO:0008053,biological_process mitochondrial fusion;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0009620,biological_process response to fungus;GO:0010046,biological_process response to mycotoxin;GO:0010225,biological_process response to UV-C;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0010332,biological_process response to gamma radiation;GO:0010524,biological_process positive regulation of calcium ion transport into cytosol;GO:0010629,biological_process negative regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019835,biological_process cytolysis;GO:0031018,biological_process endocrine pancreas development;GO:0031072,molecular_function heat shock protein binding;GO:0031100,biological_process organ regeneration;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034644,biological_process cellular response to UV;GO:0035108,biological_process limb morphogenesis;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043496,biological_process regulation of protein homodimerization activity;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0044325,molecular_function ion channel binding;GO:0044346,biological_process fibroblast apoptotic process;GO:0045471,biological_process response to ethanol;GO:0045862,biological_process positive regulation of proteolysis;GO:0046872,molecular_function metal ion binding;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0046930,cellular_component pore complex;GO:0046982,molecular_function protein heterodimerization activity;GO:0048597,biological_process post-embryonic camera-type eye morphogenesis;GO:0048872,biological_process homeostasis of number of cells;GO:0051087,molecular_function chaperone binding;GO:0051400,molecular_function BH domain binding;GO:0051726,biological_process regulation of cell cycle;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0060068,biological_process vagina development;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070242,biological_process thymocyte apoptotic process;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097145,cellular_component BAK complex;GO:0097190,biological_process apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:1900103,biological_process positive regulation of endoplasmic reticulum unfolded protein response;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1902262,biological_process apoptotic process involved in patterning of blood vessels;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response	BAK, BAK1; Bcl-2 homologous antagonist/killer; K14021	BCL2 antagonist/killer 1 [Source:HGNC Symbol%3BAcc:HGNC:949]
ENSG00000154582	262.22	245.03	242.90	268.41	254.85	267.87	-0.0642927787961333	6.62401645362838	0.322909887800448	0.701002152191962	8:73939168-73972287:-	ELOC	20;GO:0003746,molecular_function translation elongation factor activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006414,biological_process translational elongation;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070449,cellular_component elongin complex	ELOC, TCEB1; elongin-C; K03872	elongin C [Source:HGNC Symbol%3BAcc:HGNC:11617]
ENSG00000171204	80.97	82.91	84.20	80.55	80.42	78.54	0.0622605218705079	5.98640606778308	0.322913905279436	0.701002152191962	11:85628572-85636539:+	TMEM126B	10;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NA	transmembrane protein 126B [Source:HGNC Symbol%3BAcc:HGNC:30883]
ENSG00000185361	5.95	6.34	5.41	6.84	7.34	6.30	-0.204342060951589	1.88733811395352	0.323196947273356	0.701123525001408	19:4639517-4655568:+	TNFAIP8L1	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0032007,biological_process negative regulation of TOR signaling	NA	TNF alpha induced protein 8 like 1 [Source:HGNC Symbol%3BAcc:HGNC:28279]
ENSG00000111850	9.68	13.10	14.79	13.81	14.16	14.80	-0.182076115791847	2.53985037860852	0.323220667372335	0.701123525001408	6:87322582-87399749:+	SMIM8	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 8 [Source:HGNC Symbol%3BAcc:HGNC:21401]
ENSG00000138764	60.30	67.63	58.64	60.96	75.62	63.10	-0.0883714342631464	6.05795538393279	0.323226129802526	0.701123525001408	4:77157150-77433388:+	CCNG2	5;GO:0000075,biological_process cell cycle checkpoint;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	CCNG2; cyclin G2; K10146	cyclin G2 [Source:HGNC Symbol%3BAcc:HGNC:1593]
ENSG00000174886	8.65	8.22	6.59	7.23	5.81	7.95	0.166154641209863	2.6861547151826	0.323258363131534	0.701123525001408	19:5891275-5904006:-	NDUFA11	9;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11; K03956	NADH:ubiquinone oxidoreductase subunit A11 [Source:HGNC Symbol%3BAcc:HGNC:20371]
ENSG00000168374	285.63	316.47	277.86	281.86	294.91	267.83	0.0696707407590761	7.34486790336378	0.323272743145354	0.701123525001408	3:57571362-57598220:-	ARF4	29;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006471,biological_process protein ADP-ribosylation;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016477,biological_process cell migration;GO:0031012,cellular_component extracellular matrix;GO:0031584,biological_process activation of phospholipase D activity;GO:0032587,cellular_component ruffle membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060996,biological_process dendritic spine development;GO:0070062,cellular_component extracellular exosome;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	NA	ADP ribosylation factor 4 [Source:HGNC Symbol%3BAcc:HGNC:655]
ENSG00000181751	16.80	15.00	15.84	14.54	14.48	15.25	0.122837418319782	3.26838148172916	0.323308713212605	0.701123525001408	5:103258701-103278660:+	C5orf30	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0010764,biological_process negative regulation of fibroblast migration;GO:0015031,biological_process protein transport;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response	NA	chromosome 5 open reading frame 30 [Source:HGNC Symbol%3BAcc:HGNC:25052]
ENSG00000197472	0.42	0.40	0.75	0.45	0.82	0.84	-0.39111713986107	0.251126440665965	0.323512954895737	0.701202294775607	1:246945546-247008093:-	ZNF695	6;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 695 [Source:HGNC Symbol%3BAcc:HGNC:30954]
ENSG00000088280	13.53	12.14	14.13	14.73	13.47	14.24	-0.0754522694470822	5.25637118964082	0.323534045241048	0.701202294775607	1:23428562-23484568:-	ASAP3	12;GO:0001726,cellular_component ruffle;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0016477,biological_process cell migration;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051492,biological_process regulation of stress fiber assembly	ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein; K12488	ArfGAP with SH3 domain%2C ankyrin repeat and PH domain 3 [Source:HGNC Symbol%3BAcc:HGNC:14987]
ENSG00000073670	0.52	0.41	0.64	0.52	0.26	0.46	0.367667751838519	0.311583863743396	0.323611397962248	0.701202294775607	17:44759030-44781846:+	ADAM11	9;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005178,molecular_function integrin binding;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031012,cellular_component extracellular matrix	NA	ADAM metallopeptidase domain 11 [Source:HGNC Symbol%3BAcc:HGNC:189]
ENSG00000135776	4.72	4.92	4.16	3.99	4.38	4.38	0.118116549991377	3.31151021591482	0.323624208381783	0.701202294775607	1:229516581-229558695:-	ABCB10	13;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0032592,cellular_component integral component of mitochondrial membrane;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042803,molecular_function protein homodimerization activity;GO:0055085,biological_process transmembrane transport	ABCB10; ATP-binding cassette, subfamily B (MDR/TAP), member 10; K05657	ATP binding cassette subfamily B member 10 [Source:HGNC Symbol%3BAcc:HGNC:41]
ENSG00000118242	1.98	1.64	2.18	2.45	1.54	3.40	-0.329783537080516	0.661884011708266	0.323636138053606	0.701202294775607	2:215942804-216034096:-	MREG	9;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030318,biological_process melanocyte differentiation;GO:0032402,biological_process melanosome transport;GO:0042470,cellular_component melanosome;GO:0043234,cellular_component protein complex;GO:0043473,biological_process pigmentation;GO:0048066,biological_process developmental pigmentation	NA	melanoregulin [Source:HGNC Symbol%3BAcc:HGNC:25478]
ENSG00000173868	1.14	2.37	1.05	2.21	2.17	1.34	-0.35508825415049	0.937574168480935	0.323689673056874	0.701202294775607	17:49223361-49230766:-	PHOSPHO1	15;GO:0001958,biological_process endochondral ossification;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005829,cellular_component cytosol;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0016311,biological_process dephosphorylation;GO:0016462,molecular_function pyrophosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030500,biological_process regulation of bone mineralization;GO:0035630,biological_process bone mineralization involved in bone maturation;GO:0046872,molecular_function metal ion binding;GO:0052731,molecular_function phosphocholine phosphatase activity;GO:0052732,molecular_function phosphoethanolamine phosphatase activity;GO:0065010,cellular_component extracellular membrane-bounded organelle	PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75]; K06124	phosphoethanolamine/phosphocholine phosphatase [Source:HGNC Symbol%3BAcc:HGNC:16815]
ENSG00000197056	11.54	10.82	10.98	11.25	10.16	10.55	0.0746452290186053	5.22790991187782	0.32376586170449	0.701202294775607	1:35059785-35115859:+	ZMYM1	10;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity	NA	zinc finger MYM-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26253]
ENSG00000102385	0.47	0.23	0.54	0.26	0.37	0.34	0.398003080008703	0.296312186689435	0.323796951071762	0.701202294775607	X:101219768-101264497:+	DRP2	13;GO:0005886,cellular_component plasma membrane;GO:0007417,biological_process central nervous system development;GO:0008270,molecular_function zinc ion binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0043204,cellular_component perikaryon;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0050808,biological_process synapse organization	NA	dystrophin related protein 2 [Source:HGNC Symbol%3BAcc:HGNC:3032]
ENSG00000100003	8.23	7.14	8.53	7.75	6.50	7.91	0.127408416985247	3.50937359641677	0.323915573280398	0.70133682384957	22:30396856-30425317:+	SEC14L2	15;GO:0005215,molecular_function transporter activity;GO:0005543,molecular_function phospholipid binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0008431,molecular_function vitamin E binding;GO:0016021,cellular_component integral component of membrane;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0070062,cellular_component extracellular exosome	NA	SEC14 like lipid binding 2 [Source:HGNC Symbol%3BAcc:HGNC:10699]
ENSG00000134910	156.61	161.31	152.67	151.62	157.14	146.22	0.0601313278267582	8.35142742502313	0.324003946317912	0.701382212269795	11:125591711-125625215:+	STT3A	15;GO:0004576,molecular_function oligosaccharyl transferase activity;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0043686,biological_process co-translational protein modification;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	STT3; dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18]; K07151	STT3A%2C catalytic subunit of the oligosaccharyltransferase complex [Source:HGNC Symbol%3BAcc:HGNC:6172]
ENSG00000119383	87.96	88.85	100.73	96.85	103.02	94.12	-0.0706111236186636	7.3127561115046	0.32404954381433	0.701382212269795	9:129110949-129148946:+	PTPA	28;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000166,molecular_function nucleotide binding;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0008160,molecular_function protein tyrosine phosphatase activator activity;GO:0016853,molecular_function isomerase activity;GO:0016887,molecular_function ATPase activity;GO:0019211,molecular_function phosphatase activator activity;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030472,biological_process mitotic spindle organization in nucleus;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0034704,cellular_component calcium channel complex;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0035308,biological_process negative regulation of protein dephosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043666,biological_process regulation of phosphoprotein phosphatase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070062,cellular_component extracellular exosome	NA	protein phosphatase 2 phosphatase activator [Source:HGNC Symbol%3BAcc:HGNC:9308]
ENSG00000058262	96.39	101.48	89.30	87.70	98.34	89.43	0.0707597665554464	7.0919545518787	0.324143699879719	0.701463693620459	3:128051640-128071683:+	SEC61A1	19;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006620,biological_process posttranslational protein targeting to membrane;GO:0006810,biological_process transport;GO:0007029,biological_process endoplasmic reticulum organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034341,biological_process response to interferon-gamma;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0039019,biological_process pronephric nephron development;GO:0043022,molecular_function ribosome binding;GO:0045047,biological_process protein targeting to ER	SEC61A; protein transport protein SEC61 subunit alpha; K10956	Sec61 translocon alpha 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:18276]
ENSG00000001460	9.32	6.78	8.64	7.22	7.18	8.25	0.151557680539344	3.15195462441126	0.324232113156604	0.701532721041123	1:24356998-24416934:-	STPG1	9;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0090073,biological_process positive regulation of protein homodimerization activity;GO:1902110,biological_process positive regulation of mitochondrial membrane permeability involved in apoptotic process	NA	sperm tail PG-rich repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28070]
ENSG00000171425	25.57	24.09	24.28	26.98	28.49	24.63	-0.0993649298640573	3.93995029792924	0.324509298291789	0.701924453058729	19:55635458-55645622:+	ZNF581	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 581 [Source:HGNC Symbol%3BAcc:HGNC:25017]
ENSG00000179456	24.25	26.04	25.60	23.64	26.09	22.78	0.0761855850901276	5.30479254598919	0.324543272586021	0.701924453058729	1:244048938-244057476:+	ZBTB18	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000228,cellular_component nuclear chromosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007519,biological_process skeletal muscle tissue development;GO:0015630,cellular_component microtubule cytoskeleton;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045171,cellular_component intercellular bridge;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 18 [Source:HGNC Symbol%3BAcc:HGNC:13030]
ENSG00000178425	32.73	32.29	30.66	29.79	29.29	32.69	0.070483246826361	5.50691816691262	0.324582805168541	0.701924453058729	6:116100848-116249497:+	NT5DC1	4;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	5'-nucleotidase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21556]
ENSG00000123689	167.08	98.35	165.78	140.29	92.53	151.33	0.181070304714046	5.40643166695803	0.324857643812273	0.702396434879245	1:209675419-209676388:+	G0S2	8;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005811,cellular_component lipid particle;GO:0006915,biological_process apoptotic process;GO:0019216,biological_process regulation of lipid metabolic process;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	NA	G0/G1 switch 2 [Source:HGNC Symbol%3BAcc:HGNC:30229]
ENSG00000174748	1785.75	1690.24	1691.88	1724.73	1578.80	1694.17	0.0600852024684014	10.2110449521185	0.324918921676599	0.702406578678443	3:23916544-23923692:+	RPL15	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031672,cellular_component A band;GO:0045296,molecular_function cadherin binding;GO:0045471,biological_process response to ethanol;GO:0070062,cellular_component extracellular exosome	RP-L15e, RPL15; large subunit ribosomal protein L15e; K02877	ribosomal protein L15 [Source:HGNC Symbol%3BAcc:HGNC:10306]
ENSG00000054523	7.22	6.90	6.36	6.07	6.82	6.70	0.0748949592943874	5.55556306895707	0.325010725767781	0.702482698755958	1:10210804-10381603:+	KIF1B	35;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0006915,biological_process apoptotic process;GO:0007018,biological_process microtubule-based movement;GO:0007270,biological_process neuron-neuron synaptic transmission;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0008017,molecular_function microtubule binding;GO:0008089,biological_process anterograde axonal transport;GO:0010628,biological_process positive regulation of gene expression;GO:0010970,biological_process establishment of localization by movement along microtubule;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0019894,molecular_function kinesin binding;GO:0019900,molecular_function kinase binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032418,biological_process lysosome localization;GO:0043005,cellular_component neuron projection;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0097110,molecular_function scaffold protein binding;GO:1904115,cellular_component axon cytoplasm;GO:1904647,biological_process response to rotenone;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990778,biological_process protein localization to cell periphery;GO:1990939,molecular_function ATP-dependent microtubule motor activity	NA	kinesin family member 1B [Source:HGNC Symbol%3BAcc:HGNC:16636]
ENSG00000185670	3.28	3.94	3.80	2.70	3.52	3.68	0.158273539605261	2.61725702557768	0.325111210106359	0.702577550670306	11:62748318-62754188:-	ZBTB3	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:22918]
ENSG00000122126	16.46	14.81	17.10	16.81	16.92	17.64	-0.0705753308609055	5.49787650652028	0.325549124919644	0.703394829612227	X:129539848-129592561:+	OCRL	43;GO:0001701,biological_process in utero embryonic development;GO:0001750,cellular_component photoreceptor outer segment;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005929,cellular_component cilium;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030030,biological_process cell projection organization;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0034596,molecular_function phosphatidylinositol phosphate 4-phosphatase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0042995,cellular_component cell projection;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0043813,molecular_function phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048365,molecular_function Rac GTPase binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0052658,molecular_function inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0052745,molecular_function inositol phosphate phosphatase activity;GO:0060271,biological_process cilium morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]; K01099	OCRL%2C inositol polyphosphate-5-phosphatase [Source:HGNC Symbol%3BAcc:HGNC:8108]
ENSG00000151136	3.71	3.49	3.68	3.76	3.07	3.31	0.115158133254354	3.62791365567493	0.32560273027889	0.703394829612227	12:107318412-107659642:+	BTBD11	10;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0060395,biological_process SMAD protein signal transduction	NA	BTB domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:23844]
ENSG00000165813	4.40	4.11	4.86	3.83	5.12	3.13	0.163941346318869	3.53439912976818	0.325774536023669	0.703643521082618	10:114120861-114174220:-	CCDC186	NA	NA	coiled-coil domain containing 186 [Source:HGNC Symbol%3BAcc:HGNC:24349]
ENSG00000170485	5.12	4.51	4.92	5.18	5.04	5.59	-0.102612709349176	3.7888997305392	0.325839074456851	0.70366047864177	2:100820151-100996829:+	NPAS2	26;GO:0001047,molecular_function core promoter binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007417,biological_process central nervous system development;GO:0007623,biological_process circadian rhythm;GO:0019216,biological_process regulation of lipid metabolic process;GO:0032922,biological_process circadian regulation of gene expression;GO:0045739,biological_process positive regulation of DNA repair;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0051775,biological_process response to redox state;GO:0051879,molecular_function Hsp90 protein binding;GO:0060548,biological_process negative regulation of cell death;GO:2001020,biological_process regulation of response to DNA damage stimulus	NPAS2; neuronal PAS domain-containing protein 2; K09026	neuronal PAS domain protein 2 [Source:HGNC Symbol%3BAcc:HGNC:7895]
ENSG00000197816	3.70	2.73	3.19	2.61	3.03	3.28	0.127807027566036	3.99968687381471	0.326001774815254	0.703889377418985	9:97307303-97378524:+	CCDC180	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	coiled-coil domain containing 180 [Source:HGNC Symbol%3BAcc:HGNC:29303]
ENSG00000170776	8.01	7.23	7.38	7.65	8.49	7.80	-0.0683256187803238	6.09360257211314	0.326168370473227	0.704126605684203	15:85380570-85749358:+	AKAP13	40;GO:0004691,molecular_function cAMP-dependent protein kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005078,molecular_function MAP-kinase scaffold activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007507,biological_process heart development;GO:0010611,biological_process regulation of cardiac muscle hypertrophy;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0017048,molecular_function Rho GTPase binding;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0032947,molecular_function protein complex scaffold;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045859,biological_process regulation of protein kinase activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051018,molecular_function protein kinase A binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051168,biological_process nuclear export;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060297,biological_process regulation of sarcomere organization;GO:0060348,biological_process bone development;GO:0071875,biological_process adrenergic receptor signaling pathway;GO:0071883,biological_process activation of MAPK activity by adrenergic receptor signaling pathway;GO:0086023,biological_process adrenergic receptor signaling pathway involved in heart process;GO:1900169,biological_process regulation of glucocorticoid mediated signaling pathway	ARHGEF13; A-kinase anchor protein 13; K16529	A-kinase anchoring protein 13 [Source:HGNC Symbol%3BAcc:HGNC:371]
ENSG00000133318	59.81	56.19	60.71	61.83	60.44	63.57	-0.0600482780891816	7.66964859197059	0.326385099065818	0.704131634755331	11:63681445-63759891:+	RTN3	16;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016192,biological_process vesicle-mediated transport;GO:0070062,cellular_component extracellular exosome;GO:0071786,biological_process endoplasmic reticulum tubular network organization;GO:0071787,biological_process endoplasmic reticulum tubular network assembly	NA	reticulon 3 [Source:HGNC Symbol%3BAcc:HGNC:10469]
ENSG00000143390	14.58	15.93	12.46	13.73	17.95	15.03	-0.112669676887627	4.84394637607795	0.32641980228797	0.704131634755331	1:151340639-151347357:-	RFX5	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	RFX5; regulatory factor X 5; K08061	regulatory factor X5 [Source:HGNC Symbol%3BAcc:HGNC:9986]
ENSG00000167173	4.93	4.60	5.39	4.31	4.32	5.31	0.113151636974819	3.95284709472589	0.326422495172254	0.704131634755331	15:75195642-75212169:+	C15orf39	1;GO:0005829,cellular_component cytosol	NA	chromosome 15 open reading frame 39 [Source:HGNC Symbol%3BAcc:HGNC:24497]
ENSG00000181444	0.50	0.24	0.41	0.53	0.66	0.36	-0.351156338633203	0.0717016705702126	0.326438763639165	0.704131634755331	7:149764181-149773479:-	ZNF467	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 467 [Source:HGNC Symbol%3BAcc:HGNC:23154]
ENSG00000102805	4.89	5.97	4.43	4.55	4.87	4.47	0.137165057092773	3.12679012662382	0.326454326755573	0.704131634755331	13:76990659-77019143:+	CLN5	20;GO:0005515,molecular_function protein binding;GO:0005537,molecular_function mannose binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006465,biological_process signal peptide processing;GO:0007042,biological_process lysosomal lumen acidification;GO:0007420,biological_process brain development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022008,biological_process neurogenesis;GO:0030163,biological_process protein catabolic process;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042551,biological_process neuron maturation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0070085,biological_process glycosylation;GO:1904426,biological_process positive regulation of GTP binding	CLN5; ceroid-lipofuscinosis neuronal protein 5; K12390	ceroid-lipofuscinosis%2C neuronal 5 [Source:HGNC Symbol%3BAcc:HGNC:2076]
ENSG00000143797	26.81	23.02	27.53	26.55	21.91	25.02	0.0899791939240622	5.37779187618872	0.326733233216735	0.704317939301592	2:8852689-9003813:-	MBOAT2	12;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity	MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]; K13517	membrane bound O-acyltransferase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25193]
ENSG00000148334	20.61	22.05	17.64	21.12	23.00	20.77	-0.0992392924127111	4.56813149311895	0.326754768489875	0.704317939301592	9:128120692-128128462:-	PTGES2	31;GO:0000139,cellular_component Golgi membrane;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016853,molecular_function isomerase activity;GO:0019371,biological_process cyclooxygenase pathway;GO:0020037,molecular_function heme binding;GO:0035578,cellular_component azurophil granule lumen;GO:0043295,molecular_function glutathione binding;GO:0043312,biological_process neutrophil degranulation;GO:0045454,biological_process cell redox homeostasis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046903,biological_process secretion;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050220,molecular_function prostaglandin-E synthase activity;GO:0055114,biological_process oxidation-reduction process	PTGES2; microsomal prostaglandin-E synthase 2 [EC:5.3.99.3]; K05309	prostaglandin E synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:17822]
ENSG00000133131	27.13	29.60	25.83	29.26	29.45	28.46	-0.0694428084865198	6.31640479853785	0.326774121565351	0.704317939301592	X:106813870-107000244:-	MORC4	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	MORC family CW-type zinc finger 4 [Source:HGNC Symbol%3BAcc:HGNC:23485]
ENSG00000108582	67.04	64.55	68.95	64.11	63.30	66.75	0.0588544188498496	8.11098455964576	0.326776076859343	0.704317939301592	17:30378904-30469989:+	CPD	16;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0004185,molecular_function serine-type carboxypeptidase activity;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006518,biological_process peptide metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	carboxypeptidase D [Source:HGNC Symbol%3BAcc:HGNC:2301]
ENSG00000157992	2.84	2.65	1.74	1.77	2.00	2.15	0.291208010830317	0.785044524902738	0.326838568456413	0.704317939301592	2:27442365-27446481:+	KRTCAP3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	keratinocyte associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:28943]
ENSG00000130204	38.61	41.79	38.53	44.12	40.79	40.94	-0.0730243885477351	5.52506199727218	0.326881144631956	0.704317939301592	19:44890568-44903689:+	TOMM40	21;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008320,molecular_function protein transmembrane transporter activity;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0015288,molecular_function porin activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0046930,cellular_component pore complex;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	TOM40; mitochondrial import receptor subunit TOM40; K11518	translocase of outer mitochondrial membrane 40 [Source:HGNC Symbol%3BAcc:HGNC:18001]
ENSG00000148300	20.31	20.99	21.16	19.69	20.31	19.61	0.0782004203805162	4.69501475687017	0.32694002228334	0.704322543665931	9:133406058-133418096:-	REXO4	11;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	REX4 homolog%2C 3'-5' exonuclease [Source:HGNC Symbol%3BAcc:HGNC:12820]
ENSG00000146530	0.38	0.35	0.30	0.48	0.38	0.38	-0.264443110228832	1.0279204226182	0.32708951232542	0.704499966294022	7:12330884-12403941:-	VWDE	2;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region	NA	von Willebrand factor D and EGF domains [Source:HGNC Symbol%3BAcc:HGNC:21897]
ENSG00000090316	46.05	46.29	45.03	46.34	49.50	48.76	-0.0627330334626003	6.20817401467605	0.327135890253665	0.704499966294022	4:1289850-1340147:+	MAEA	26;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005826,cellular_component actomyosin contractile ring;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0033033,biological_process negative regulation of myeloid cell apoptotic process;GO:0034657,cellular_component GID complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043249,biological_process erythrocyte maturation;GO:0045721,biological_process negative regulation of gluconeogenesis;GO:0048821,biological_process erythrocyte development;GO:0048822,biological_process enucleate erythrocyte development;GO:0051301,biological_process cell division	NA	macrophage erythroblast attacher [Source:HGNC Symbol%3BAcc:HGNC:13731]
ENSG00000086189	16.51	17.12	15.42	17.20	14.74	13.88	0.108015759803846	3.97680936615082	0.327195683960909	0.704506509107853	5:62387253-62403939:-	DIMT1	15;GO:0000154,biological_process rRNA modification;GO:0000179,molecular_function rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008649,molecular_function rRNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0052909,molecular_function 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity	NA	DIM1 dimethyladenosine transferase 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:30217]
ENSG00000175066	5.63	5.25	7.26	5.41	6.05	5.23	0.141212662248555	3.45307688532517	0.327252958594869	0.704507626610842	3:142157526-142225607:-	GK5	13;GO:0000166,molecular_function nucleotide binding;GO:0004370,molecular_function glycerol kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005975,biological_process carbohydrate metabolic process;GO:0006071,biological_process glycerol metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019563,biological_process glycerol catabolic process;GO:0046167,biological_process glycerol-3-phosphate biosynthetic process	NA	glycerol kinase 5 (putative) [Source:HGNC Symbol%3BAcc:HGNC:28635]
ENSG00000136144	5.23	5.82	5.27	4.70	5.24	5.08	0.124167868421613	3.07816895863578	0.327361752146988	0.704535326010518	13:49531945-49585583:-	RCBTB1	6;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0016569,biological_process covalent chromatin modification	NA	RCC1 and BTB domain containing protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18243]
ENSG00000139194	21.33	21.54	19.97	21.13	26.22	21.70	-0.124828220457118	3.35036354803884	0.327379341047987	0.704535326010518	12:7123683-7128942:-	RBP5	9;GO:0005215,molecular_function transporter activity;GO:0005501,molecular_function retinoid binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0016918,molecular_function retinal binding;GO:0019841,molecular_function retinol binding;GO:0070062,cellular_component extracellular exosome	NA	retinol binding protein 5 [Source:HGNC Symbol%3BAcc:HGNC:15847]
ENSG00000169230	125.45	134.79	122.73	135.38	137.14	131.19	-0.06604949712505	6.6823655525024	0.327543394888882	0.704766191845328	5:177303773-177306959:+	PRELID1	23;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0007275,biological_process multicellular organism development;GO:0010917,biological_process negative regulation of mitochondrial membrane potential;GO:0010950,biological_process positive regulation of endopeptidase activity;GO:0015914,biological_process phospholipid transport;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045580,biological_process regulation of T cell differentiation;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0070234,biological_process positive regulation of T cell apoptotic process;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097035,biological_process regulation of membrane lipid distribution;GO:1901857,biological_process positive regulation of cellular respiration;GO:1990050,molecular_function phosphatidic acid transporter activity;GO:2001140,biological_process positive regulation of phospholipid transport	NA	PRELI domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30255]
ENSG00000169129	0.73	0.84	0.70	1.13	0.79	0.84	-0.276901795901392	1.17315951257079	0.327662231235683	0.70489970127011	10:114294823-114404756:-	AFAP1L2	16;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0009966,biological_process regulation of signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0030296,molecular_function protein tyrosine kinase activator activity;GO:0032675,biological_process regulation of interleukin-6 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0035591,molecular_function signaling adaptor activity;GO:0042169,molecular_function SH2 domain binding;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity	NA	actin filament associated protein 1 like 2 [Source:HGNC Symbol%3BAcc:HGNC:25901]
ENSG00000152193	5.97	6.58	6.52	6.39	6.27	5.04	0.118613772833397	3.7510959441507	0.32797415763719	0.705448487047381	13:78614290-78659179:-	RNF219	2;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 219 [Source:HGNC Symbol%3BAcc:HGNC:20308]
ENSG00000214013	5.70	5.86	5.59	6.10	6.23	6.00	-0.0861843718687952	4.35035796179503	0.328309558103657	0.70604756492389	15:42273232-42356935:+	GANC	10;GO:0000023,biological_process maltose metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004558,molecular_function alpha-1,4-glucosidase activity;GO:0005975,biological_process carbohydrate metabolic process;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030246,molecular_function carbohydrate binding;GO:0032450,molecular_function maltose alpha-glucosidase activity	GANC; neutral alpha-glucosidase C [EC:3.2.1.20]; K12317	glucosidase alpha%2C neutral C [Source:HGNC Symbol%3BAcc:HGNC:4139]
ENSG00000142910	82.77	105.32	75.23	73.80	97.71	72.23	0.121993186821264	6.88748278955844	0.328546369492491	0.706434450807256	1:31576484-31587686:+	TINAGL1	16;GO:0005044,molecular_function scavenger receptor activity;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016197,biological_process endosomal transport;GO:0030247,molecular_function polysaccharide binding;GO:0031012,cellular_component extracellular matrix;GO:0043236,molecular_function laminin binding;GO:0070062,cellular_component extracellular exosome	NA	tubulointerstitial nephritis antigen like 1 [Source:HGNC Symbol%3BAcc:HGNC:19168]
ENSG00000188846	869.38	840.28	830.65	923.51	837.96	908.96	-0.0602771333599217	9.44338817800453	0.328675443301645	0.706589587409651	3:40457291-40468587:+	RPL14	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	RP-L14e, RPL14; large subunit ribosomal protein L14e; K02875	ribosomal protein L14 [Source:HGNC Symbol%3BAcc:HGNC:10305]
ENSG00000163946	28.35	27.12	30.16	26.88	28.15	27.62	0.0639265480544519	7.15268538273324	0.328810316403858	0.706599882284375	3:56620132-56683237:-	FAM208A	6;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	family with sequence similarity 208 member A [Source:HGNC Symbol%3BAcc:HGNC:30314]
ENSG00000132481	10.79	9.98	12.08	12.29	10.77	12.33	-0.0911543712382164	4.66612588210409	0.328812114481154	0.706599882284375	17:75874160-75878575:-	TRIM47	6;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 47 [Source:HGNC Symbol%3BAcc:HGNC:19020]
ENSG00000131467	56.21	58.04	53.44	60.37	58.94	57.50	-0.066602856373726	5.78876568729706	0.328861369659926	0.706599882284375	17:42824384-42843758:+	PSME3	42;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002039,molecular_function p53 binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008537,cellular_component proteasome activator complex;GO:0010950,biological_process positive regulation of endopeptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061133,molecular_function endopeptidase activator activity;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097371,molecular_function MDM2/MDM4 family protein binding;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	PSME3; proteasome activator subunit 3 (PA28 gamma); K06698	proteasome activator subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:9570]
ENSG00000161551	7.44	6.49	7.85	6.21	6.65	7.36	0.12660343359362	3.39087710763358	0.328941200083179	0.706599882284375	19:51804815-51890950:-	ZNF577	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 577 [Source:HGNC Symbol%3BAcc:HGNC:28673]
ENSG00000077044	13.48	10.84	13.70	14.18	12.68	13.87	-0.0829168307155288	5.7334361872675	0.329166991767477	0.706599882284375	2:233354506-233472104:+	DGKD	34;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008152,biological_process metabolic process;GO:0010033,biological_process response to organic substance;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019932,biological_process second-messenger-mediated signaling;GO:0019992,molecular_function diacylglycerol binding;GO:0030168,biological_process platelet activation;GO:0035556,biological_process intracellular signal transduction;GO:0042803,molecular_function protein homodimerization activity;GO:0046339,biological_process diacylglycerol metabolic process;GO:0046834,biological_process lipid phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051260,biological_process protein homooligomerization	dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]; K00901	diacylglycerol kinase delta [Source:HGNC Symbol%3BAcc:HGNC:2851]
ENSG00000253729	54.10	60.62	51.99	58.74	60.97	56.59	-0.0693007444960585	9.46857601311292	0.329186860126867	0.706599882284375	8:47773107-47960183:-	PRKDC	76;GO:0000166,molecular_function nucleotide binding;GO:0000723,biological_process telomere maintenance;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001756,biological_process somitogenesis;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002326,biological_process B cell lineage commitment;GO:0002328,biological_process pro-B cell differentiation;GO:0002360,biological_process T cell lineage commitment;GO:0002377,biological_process immunoglobulin production;GO:0002638,biological_process negative regulation of immunoglobulin production;GO:0002684,biological_process positive regulation of immune system process;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004677,molecular_function DNA-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005958,cellular_component DNA-dependent protein kinase-DNA ligase 4 complex;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010212,biological_process response to ionizing radiation;GO:0010332,biological_process response to gamma radiation;GO:0014823,biological_process response to activity;GO:0016020,cellular_component membrane;GO:0016233,biological_process telomere capping;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030098,biological_process lymphocyte differentiation;GO:0031012,cellular_component extracellular matrix;GO:0031648,biological_process protein destabilization;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032993,cellular_component protein-DNA complex;GO:0033077,biological_process T cell differentiation in thymus;GO:0033151,biological_process V(D)J recombination;GO:0033152,biological_process immunoglobulin V(D)J recombination;GO:0033153,biological_process T cell receptor V(D)J recombination;GO:0035234,biological_process ectopic germ cell programmed cell death;GO:0042752,biological_process regulation of circadian rhythm;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048511,biological_process rhythmic process;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0048639,biological_process positive regulation of developmental growth;GO:0048660,biological_process regulation of smooth muscle cell proliferation;GO:0070419,cellular_component nonhomologous end joining complex;GO:0072431,biological_process signal transduction involved in mitotic G1 DNA damage checkpoint;GO:0097681,biological_process double-strand break repair via alternative nonhomologous end joining;GO:2000773,biological_process negative regulation of cellular senescence;GO:2001229,biological_process negative regulation of response to gamma radiation	PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]; K06642	protein kinase%2C DNA-activated%2C catalytic polypeptide [Source:HGNC Symbol%3BAcc:HGNC:9413]
ENSG00000197951	5.83	3.84	4.06	4.54	3.46	4.22	0.190349069519129	2.70924178799994	0.329214543372152	0.706599882284375	19:56595263-56626481:+	ZNF71	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 71 [Source:HGNC Symbol%3BAcc:HGNC:13141]
ENSG00000215251	7.64	8.01	7.39	7.35	9.40	8.22	-0.107093198038485	4.2085644606323	0.329222105143925	0.706599882284375	20:3146518-3159897:-	FASTKD5	11;GO:0000963,biological_process mitochondrial RNA processing;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0019843,molecular_function rRNA binding;GO:0035770,cellular_component ribonucleoprotein granule;GO:0042645,cellular_component mitochondrial nucleoid;GO:0045333,biological_process cellular respiration	NA	FAST kinase domains 5 [Source:HGNC Symbol%3BAcc:HGNC:25790]
ENSG00000124171	14.28	17.12	15.01	16.03	18.44	15.72	-0.108134469048544	4.24682870914036	0.329251723646172	0.706599882284375	20:50731543-50756795:+	PARD6B	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0005938,cellular_component cell cortex;GO:0006461,biological_process protein complex assembly;GO:0007043,biological_process cell-cell junction assembly;GO:0007049,biological_process cell cycle;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007409,biological_process axonogenesis;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction;GO:0030334,biological_process regulation of cell migration;GO:0043234,cellular_component protein complex;GO:0045177,cellular_component apical part of cell;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly	PARD6; partitioning defective protein 6; K06093	par-6 family cell polarity regulator beta [Source:HGNC Symbol%3BAcc:HGNC:16245]
ENSG00000144036	7.72	7.62	8.66	8.90	8.20	8.66	-0.0875960060915992	4.39175830833503	0.329298771926125	0.706599882284375	2:72175983-72826041:-	EXOC6B	6;GO:0000145,cellular_component exocyst;GO:0005515,molecular_function protein binding;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0015031,biological_process protein transport	NA	exocyst complex component 6B [Source:HGNC Symbol%3BAcc:HGNC:17085]
ENSG00000125864	1.41	1.15	1.11	1.05	0.72	1.30	0.265947705726833	1.26652793918131	0.329306398051648	0.706599882284375	20:17493904-17569220:-	BFSP1	14;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005212,molecular_function structural constituent of eye lens;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0007010,biological_process cytoskeleton organization;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0048469,biological_process cell maturation;GO:0070307,biological_process lens fiber cell development	NA	beaded filament structural protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1040]
ENSG00000117408	24.33	23.53	24.41	25.21	25.62	25.21	-0.0601926685319286	6.18784407386743	0.329447040869729	0.706779488129268	1:43946938-43968022:+	IPO13	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0031965,cellular_component nuclear membrane	NA	importin 13 [Source:HGNC Symbol%3BAcc:HGNC:16853]
ENSG00000182919	9.10	9.71	9.33	10.11	11.36	9.42	-0.125050831916426	3.2543778317571	0.329637494549453	0.707065875210361	11:93741590-93764749:+	C11orf54	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008270,molecular_function zinc ion binding;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	chromosome 11 open reading frame 54 [Source:HGNC Symbol%3BAcc:HGNC:30204]
ENSG00000132478	11.54	12.53	11.48	11.17	11.08	11.66	0.0744407779987752	4.88010229976225	0.329964935155392	0.707388705747211	17:75784770-75825799:+	UNK	9;GO:0001764,biological_process neuron migration;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0006417,biological_process regulation of translation;GO:0046872,molecular_function metal ion binding;GO:0048667,biological_process cell morphogenesis involved in neuron differentiation;GO:1990715,molecular_function mRNA CDS binding;GO:2000766,biological_process negative regulation of cytoplasmic translation	NA	unkempt family zinc finger [Source:HGNC Symbol%3BAcc:HGNC:29369]
ENSG00000123096	7.00	5.50	8.47	6.01	4.26	7.91	0.223807817960027	2.34241957800537	0.33005024014524	0.707388705747211	12:26121990-26299290:+	SSPN	12;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006936,biological_process muscle contraction;GO:0007155,biological_process cell adhesion;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030133,cellular_component transport vesicle;GO:0042383,cellular_component sarcolemma;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	sarcospan [Source:HGNC Symbol%3BAcc:HGNC:11322]
ENSG00000178951	16.93	14.29	14.70	15.38	13.98	14.25	0.0913550596576856	4.71949550449284	0.330100435302947	0.707388705747211	19:4044363-4066945:-	ZBTB7A	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0035035,molecular_function histone acetyltransferase binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 7A [Source:HGNC Symbol%3BAcc:HGNC:18078]
ENSG00000108239	4.04	3.78	3.48	3.38	3.49	3.57	0.126314290922883	3.10049618473619	0.330115637625263	0.707388705747211	10:94402503-94535930:+	TBC1D12	8;GO:0005096,molecular_function GTPase activator activity;GO:0005776,cellular_component autophagosome;GO:0006886,biological_process intracellular protein transport;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0055037,cellular_component recycling endosome;GO:0090630,biological_process activation of GTPase activity;GO:2000785,biological_process regulation of autophagosome assembly	NA	TBC1 domain family member 12 [Source:HGNC Symbol%3BAcc:HGNC:29082]
ENSG00000273079	0.30	0.42	0.24	0.33	0.22	0.22	0.309781372198838	0.518663397703493	0.330125715373761	0.707388705747211	12:13437941-13981957:-	GRIN2B	34;GO:0000165,biological_process MAPK cascade;GO:0004872,molecular_function receptor activity;GO:0004970,molecular_function ionotropic glutamate receptor activity;GO:0004972,molecular_function NMDA glutamate receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005216,molecular_function ion channel activity;GO:0005234,molecular_function extracellular-glutamate-gated ion channel activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007215,biological_process glutamate receptor signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0007611,biological_process learning or memory;GO:0008270,molecular_function zinc ion binding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016594,molecular_function glycine binding;GO:0017146,cellular_component NMDA selective glutamate receptor complex;GO:0030054,cellular_component cell junction;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0043005,cellular_component neuron projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0060079,biological_process excitatory postsynaptic potential	GRIN2B; glutamate receptor ionotropic, NMDA 2B; K05210	glutamate ionotropic receptor NMDA type subunit 2B [Source:HGNC Symbol%3BAcc:HGNC:4586]
ENSG00000144231	22.05	25.35	24.19	27.59	24.75	25.75	-0.120500887655719	3.42926687718393	0.330129926076983	0.707388705747211	2:127843550-127858157:-	POLR2D	30;GO:0000166,molecular_function nucleotide binding;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003697,molecular_function single-stranded DNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003824,molecular_function catalytic activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0016607,cellular_component nuclear speck;GO:0031369,molecular_function translation initiation factor binding;GO:0031990,biological_process mRNA export from nucleus in response to heat stress;GO:0034402,biological_process recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0044237,biological_process cellular metabolic process;GO:0045948,biological_process positive regulation of translational initiation;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB4, POLR2D; DNA-directed RNA polymerase II subunit RPB4; K03012	RNA polymerase II subunit D [Source:HGNC Symbol%3BAcc:HGNC:9191]
ENSG00000187187	3.02	3.03	3.09	2.43	2.94	3.03	0.132960661677503	3.01481448782948	0.330246254059357	0.707515835629755	19:39984133-40021041:+	ZNF546	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 546 [Source:HGNC Symbol%3BAcc:HGNC:28671]
ENSG00000176108	17.76	16.99	16.50	18.06	17.61	19.51	-0.0952237130931518	3.98597986869938	0.330341399675811	0.707597548606702	17:80991597-81009517:+	CHMP6	25;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0010008,cellular_component endosome membrane;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0031902,cellular_component late endosome membrane;GO:0032403,molecular_function protein complex binding;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0047485,molecular_function protein N-terminus binding;GO:0070062,cellular_component extracellular exosome;GO:1904902,biological_process ESCRT III complex assembly	CHMP6, VPS20; charged multivesicular body protein 6; K12195	charged multivesicular body protein 6 [Source:HGNC Symbol%3BAcc:HGNC:25675]
ENSG00000196388	18.85	14.85	20.06	18.29	14.03	17.18	0.13987160367873	3.63255542592305	0.330430136254565	0.707665507475486	17:4988129-4997610:-	INCA1	10;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016604,cellular_component nuclear body;GO:0030332,molecular_function cyclin binding;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	inhibitor of CDK%2C cyclin A1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:32224]
ENSG00000198569	1.69	1.86	2.13	1.75	1.73	1.49	0.207280693123175	1.73680472718435	0.330524569530669	0.707745641121992	9:137230756-137236554:+	SLC34A3	20;GO:0005436,molecular_function sodium:phosphate symporter activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006817,biological_process phosphate ion transport;GO:0015293,molecular_function symporter activity;GO:0015321,molecular_function sodium-dependent phosphate transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030643,biological_process cellular phosphate ion homeostasis;GO:0031526,cellular_component brush border membrane;GO:0031982,cellular_component vesicle;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0044341,biological_process sodium-dependent phosphate transport;GO:0055085,biological_process transmembrane transport	SLC34A, NPT, nptA; solute carrier family 34 (sodium-dependent phosphate cotransporter); K14683	solute carrier family 34 member 3 [Source:HGNC Symbol%3BAcc:HGNC:20305]
ENSG00000165985	1.29	0.62	1.25	1.47	1.29	1.47	-0.356351541167102	0.155704824691	0.330644573300225	0.70788049126866	10:16513742-16522005:-	C1QL3	3;GO:0005576,cellular_component extracellular region;GO:0005581,cellular_component collagen trimer;GO:0050807,biological_process regulation of synapse organization	NA	complement C1q like 3 [Source:HGNC Symbol%3BAcc:HGNC:19359]
ENSG00000164109	65.57	81.89	63.91	71.46	77.57	77.29	-0.0933700519975757	5.49003170055121	0.330735041312844	0.707901469122129	4:120055607-120067074:-	MAD2L1	32;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0072686,cellular_component mitotic spindle;GO:0090267,biological_process positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:1904667,biological_process negative regulation of ubiquitin protein ligase activity	MAD2; mitotic spindle assembly checkpoint protein MAD2; K02537	mitotic arrest deficient 2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:6763]
ENSG00000072840	25.77	26.31	26.80	26.37	28.62	28.08	-0.0631076498107117	6.35176783367604	0.330768429945086	0.707901469122129	4:5711196-5814305:+	EVC	17;GO:0001501,biological_process skeletal system development;GO:0003416,biological_process endochondral bone growth;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0007517,biological_process muscle organ development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019538,biological_process protein metabolic process;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0051216,biological_process cartilage development;GO:0060170,cellular_component ciliary membrane;GO:0098797,cellular_component plasma membrane protein complex	NA	EvC ciliary complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:3497]
ENSG00000051009	12.75	11.38	12.95	12.32	11.34	11.90	0.0769544394692424	5.30941071462416	0.330836608131879	0.707925326106018	11:6211334-6234711:-	FAM160A2	9;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0045022,biological_process early endosome to late endosome transport;GO:0070695,cellular_component FHF complex	NA	family with sequence similarity 160 member A2 [Source:HGNC Symbol%3BAcc:HGNC:25378]
ENSG00000115998	7.59	6.60	6.07	6.70	7.97	7.55	-0.118474867286016	3.62950431894485	0.331198065169167	0.708576625809182	2:70149879-70248615:-	C2orf42	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0031965,cellular_component nuclear membrane	NA	chromosome 2 open reading frame 42 [Source:HGNC Symbol%3BAcc:HGNC:26056]
ENSG00000127993	11.99	11.34	12.50	15.43	11.94	11.88	-0.115704650422152	3.94181069801283	0.331657086099718	0.709322527983711	7:92528772-92538005:+	RBM48	3;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005654,cellular_component nucleoplasm	NA	RNA binding motif protein 48 [Source:HGNC Symbol%3BAcc:HGNC:21785]
ENSG00000116675	1.46	1.41	0.94	1.40	1.49	1.50	-0.200286419712151	2.11087743713677	0.331704276032416	0.709322527983711	1:65248218-65415869:+	DNAJC6	15;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006898,biological_process receptor-mediated endocytosis;GO:0014069,cellular_component postsynaptic density;GO:0016191,biological_process synaptic vesicle uncoating;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0031982,cellular_component vesicle;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0045202,cellular_component synapse;GO:0061024,biological_process membrane organization;GO:0072318,biological_process clathrin coat disassembly;GO:2000369,biological_process regulation of clathrin-mediated endocytosis	DNAJC6; DnaJ homolog subfamily C member 6; K09526	DnaJ heat shock protein family (Hsp40) member C6 [Source:HGNC Symbol%3BAcc:HGNC:15469]
ENSG00000197362	2.71	3.06	2.98	3.32	3.65	2.79	-0.148468790624686	2.88307490165863	0.331758009588301	0.709322527983711	7:149069642-149090782:-	ZNF786	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 786 [Source:HGNC Symbol%3BAcc:HGNC:21806]
ENSG00000132535	16.10	15.06	17.64	16.43	14.34	15.84	0.0811058874270381	5.36075141634872	0.33185692879896	0.709322527983711	17:7189889-7219702:-	DLG4	74;GO:0000165,biological_process MAPK cascade;GO:0002091,biological_process negative regulation of receptor internalization;GO:0004385,molecular_function guanylate kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0007165,biological_process signal transduction;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0007612,biological_process learning;GO:0008021,cellular_component synaptic vesicle;GO:0008022,molecular_function protein C-terminus binding;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0014069,cellular_component postsynaptic density;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0016020,cellular_component membrane;GO:0016188,biological_process synaptic vesicle maturation;GO:0016323,cellular_component basolateral plasma membrane;GO:0019900,molecular_function kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030863,cellular_component cortical cytoskeleton;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031697,molecular_function beta-1 adrenergic receptor binding;GO:0031748,molecular_function D1 dopamine receptor binding;GO:0031812,molecular_function P2Y1 nucleotide receptor binding;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0032403,molecular_function protein complex binding;GO:0032839,cellular_component dendrite cytoplasm;GO:0033130,molecular_function acetylcholine receptor binding;GO:0034220,biological_process ion transmembrane transport;GO:0035176,biological_process social behavior;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035418,biological_process protein localization to synapse;GO:0035641,biological_process locomotory exploration behavior;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044224,cellular_component juxtaparanode region of axon;GO:0044300,cellular_component cerebellar mossy fiber;GO:0044306,cellular_component neuron projection terminus;GO:0044309,cellular_component neuron spine;GO:0045184,biological_process establishment of protein localization;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0050806,biological_process positive regulation of synaptic transmission;GO:0050885,biological_process neuromuscular process controlling balance;GO:0060076,cellular_component excitatory synapse;GO:0060997,biological_process dendritic spine morphogenesis;GO:0071625,biological_process vocalization behavior;GO:0071944,cellular_component cell periphery;GO:0097060,cellular_component synaptic membrane;GO:0097109,molecular_function neuroligin family protein binding;GO:0097110,molecular_function scaffold protein binding;GO:0097113,biological_process AMPA glutamate receptor clustering;GO:0097120,biological_process receptor localization to synapse;GO:0098839,cellular_component postsynaptic density membrane;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000821,biological_process regulation of grooming behavior	DLG4, PSD95; discs large protein 4; K11828	discs large MAGUK scaffold protein 4 [Source:HGNC Symbol%3BAcc:HGNC:2903]
ENSG00000185689	3.02	2.20	2.30	2.46	1.99	1.62	0.337152999587879	0.616042719902595	0.331897928273095	0.709322527983711	6:4079208-4130951:+	C6orf201	NA	NA	chromosome 6 open reading frame 201 [Source:HGNC Symbol%3BAcc:HGNC:21620]
ENSG00000121073	21.66	23.37	20.04	18.88	21.54	21.15	0.086075926214889	4.65709102829465	0.331949019415407	0.709322527983711	17:49700942-49709014:-	SLC35B1	12;GO:0005459,molecular_function UDP-galactose transmembrane transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055085,biological_process transmembrane transport;GO:0072334,biological_process UDP-galactose transmembrane transport	NA	solute carrier family 35 member B1 [Source:HGNC Symbol%3BAcc:HGNC:20798]
ENSG00000168944	8.44	8.33	7.46	9.04	8.53	8.27	-0.083057084277563	4.79432312561817	0.331998019614766	0.709322527983711	5:123344884-123423592:-	CEP120	18;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007098,biological_process centrosome cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0010825,biological_process positive regulation of centrosome duplication;GO:0021987,biological_process cerebral cortex development;GO:0022008,biological_process neurogenesis;GO:0022027,biological_process interkinetic nuclear migration;GO:0030953,biological_process astral microtubule organization;GO:0032880,biological_process regulation of protein localization;GO:0032886,biological_process regulation of microtubule-based process;GO:0045724,biological_process positive regulation of cilium assembly	NA	centrosomal protein 120 [Source:HGNC Symbol%3BAcc:HGNC:26690]
ENSG00000070540	18.38	21.50	19.05	18.83	17.51	19.44	0.0834098432727016	4.70623714232795	0.332003857857517	0.709322527983711	17:68420947-68457513:-	WIPI1	28;GO:0000139,cellular_component Golgi membrane;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000421,cellular_component autophagosome membrane;GO:0000422,biological_process mitophagy;GO:0005102,molecular_function receptor binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006497,biological_process protein lipidation;GO:0006914,biological_process autophagy;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0019898,cellular_component extrinsic component of membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030331,molecular_function estrogen receptor binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0044804,biological_process nucleophagy;GO:0048203,biological_process vesicle targeting, trans-Golgi to endosome;GO:0050681,molecular_function androgen receptor binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	WD repeat domain%2C phosphoinositide interacting 1 [Source:HGNC Symbol%3BAcc:HGNC:25471]
ENSG00000153140	30.72	31.81	30.88	33.50	32.87	33.31	-0.0843827646212719	4.38901164694827	0.332096680168421	0.709326653257903	5:90392260-90409786:-	CETN3	18;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0008017,molecular_function microtubule binding;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	NA	centrin 3 [Source:HGNC Symbol%3BAcc:HGNC:1868]
ENSG00000232040	3.16	2.86	3.15	2.98	3.64	3.38	-0.107151710643596	3.68847440024304	0.332151502773535	0.709326653257903	6:28571629-28616212:-	ZBED9	10;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0015074,biological_process DNA integration	NA	zinc finger BED-type containing 9 [Source:HGNC Symbol%3BAcc:HGNC:13851]
ENSG00000166181	50.32	48.26	51.45	48.22	49.06	47.73	0.0622342136468768	6.45864886443455	0.332177220284233	0.709326653257903	11:43311962-43344529:+	API5	11;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0017134,molecular_function fibroblast growth factor binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:2000270,biological_process negative regulation of fibroblast apoptotic process	NA	apoptosis inhibitor 5 [Source:HGNC Symbol%3BAcc:HGNC:594]
ENSG00000213096	5.19	6.10	5.57	5.40	5.16	5.13	0.107888612447816	3.58545284960056	0.332243996744154	0.709347219054899	19:24033404-24129961:+	ZNF254	9;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 254 [Source:HGNC Symbol%3BAcc:HGNC:13047]
ENSG00000188786	5.91	5.67	4.72	5.00	4.83	5.26	0.118769086010883	3.58064394508057	0.332426992849917	0.70950882422219	1:37809566-37859620:-	MTF1	22;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006979,biological_process response to oxidative stress;GO:0010038,biological_process response to metal ion;GO:0035035,molecular_function histone acetyltransferase binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding	NA	metal regulatory transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:7428]
ENSG00000214941	27.93	26.99	24.02	27.10	30.78	27.95	-0.109692692761946	3.73194274863567	0.332438868133974	0.70950882422219	17:15976559-15999717:-	ZSWIM7	10;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0097196,cellular_component Shu complex	NA	zinc finger SWIM-type containing 7 [Source:HGNC Symbol%3BAcc:HGNC:26993]
ENSG00000136718	41.82	42.44	41.83	42.01	38.94	40.25	0.0678215762118731	5.32095326153514	0.332491164948077	0.70950882422219	2:130342224-130347810:+	IMP4	12;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032040,cellular_component small-subunit processome;GO:0034457,cellular_component Mpp10 complex;GO:0042134,molecular_function rRNA primary transcript binding;GO:0042254,biological_process ribosome biogenesis	IMP4; U3 small nucleolar ribonucleoprotein protein IMP4; K14561	IMP4%2C U3 small nucleolar ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:30856]
ENSG00000126787	34.44	40.20	32.64	34.92	43.10	36.99	-0.0904621376817286	6.60746986335803	0.332601784086725	0.709590105440734	14:55148111-55191678:-	DLGAP5	17;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006461,biological_process protein complex assembly;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0007079,biological_process mitotic chromosome movement towards spindle pole;GO:0008283,biological_process cell proliferation;GO:0023052,biological_process signaling;GO:0031616,cellular_component spindle pole centrosome;GO:0045842,biological_process positive regulation of mitotic metaphase/anaphase transition	NA	DLG associated protein 5 [Source:HGNC Symbol%3BAcc:HGNC:16864]
ENSG00000163939	11.16	10.45	11.76	10.44	11.04	10.67	0.0686747611445222	5.80871849221849	0.332643585238027	0.709590105440734	3:52545351-52685917:-	PBRM1	13;GO:0000228,cellular_component nuclear chromosome;GO:0000278,biological_process mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0090544,cellular_component BAF-type complex	PBRM1, PB1; protein polybromo-1; K11757	polybromo 1 [Source:HGNC Symbol%3BAcc:HGNC:30064]
ENSG00000142233	0.72	0.33	1.61	0.56	0.47	0.96	0.453935097393014	0.396202040560972	0.332773569765336	0.709730229720388	19:48661406-48673081:-	NTN5	1;GO:0005576,cellular_component extracellular region	NA	netrin 5 [Source:HGNC Symbol%3BAcc:HGNC:25208]
ENSG00000092607	13.94	12.04	13.95	13.99	12.66	10.96	0.104200549290971	4.63311099470348	0.332823625811841	0.709730229720388	1:118883045-118989556:-	TBX15	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042803,molecular_function protein homodimerization activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0070722,cellular_component Tle3-Aes complex	NA	T-box 15 [Source:HGNC Symbol%3BAcc:HGNC:11594]
ENSG00000124357	45.15	47.50	46.74	41.78	45.92	46.38	0.0660383653015587	5.75447500627777	0.33317067817229	0.710095117958123	2:71064343-71079805:+	NAGK	14;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0006051,biological_process N-acetylmannosamine metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019262,biological_process N-acetylneuraminate catabolic process;GO:0045127,molecular_function N-acetylglucosamine kinase activity;GO:0046835,biological_process carbohydrate phosphorylation;GO:0070062,cellular_component extracellular exosome	NAGK, nagK; N-acetylglucosamine kinase [EC:2.7.1.59]; K00884	N-acetylglucosamine kinase [Source:HGNC Symbol%3BAcc:HGNC:17174]
ENSG00000168765	13.98	12.15	13.36	13.98	13.53	15.51	-0.10591626805842	3.7673381451132	0.333198239686623	0.710095117958123	1:109656080-109674836:+	GSTM4	13;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0018916,biological_process nitrobenzene metabolic process;GO:0019899,molecular_function enzyme binding;GO:0042178,biological_process xenobiotic catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043295,molecular_function glutathione binding;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase mu 4 [Source:HGNC Symbol%3BAcc:HGNC:4636]
ENSG00000110075	30.30	31.70	30.19	31.86	32.33	32.76	-0.062287127207224	6.49492121894302	0.333223614077248	0.710095117958123	11:68460730-68615334:+	PPP6R3	11;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006516,biological_process glycoprotein catabolic process;GO:0019903,molecular_function protein phosphatase binding;GO:0043666,biological_process regulation of phosphoprotein phosphatase activity;GO:0048208,biological_process COPII vesicle coating	NA	protein phosphatase 6 regulatory subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:1173]
ENSG00000197385	1.53	2.22	1.86	2.29	2.04	2.11	-0.209187925217454	1.97906683372782	0.333295503555064	0.710095117958123	3:31981770-31991628:+	ZNF860	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 860 [Source:HGNC Symbol%3BAcc:HGNC:34513]
ENSG00000122861	56.84	52.64	57.18	58.51	46.64	54.00	0.0796208590105931	6.17585753756273	0.33330761774119	0.710095117958123	10:73909176-73917497:+	PLAU	30;GO:0001666,biological_process response to hypoxia;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006935,biological_process chemotaxis;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009986,cellular_component cell surface;GO:0010469,biological_process regulation of receptor activity;GO:0014909,biological_process smooth muscle cell migration;GO:0014910,biological_process regulation of smooth muscle cell migration;GO:0016787,molecular_function hydrolase activity;GO:0030335,biological_process positive regulation of cell migration;GO:0031639,biological_process plasminogen activation;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0035579,cellular_component specific granule membrane;GO:0042127,biological_process regulation of cell proliferation;GO:0042730,biological_process fibrinolysis;GO:0043312,biological_process neutrophil degranulation;GO:0061041,biological_process regulation of wound healing;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:2000097,biological_process regulation of smooth muscle cell-matrix adhesion	PLAU; urokinase plasminogen activator [EC:3.4.21.73]; K01348	plasminogen activator%2C urokinase [Source:HGNC Symbol%3BAcc:HGNC:9052]
ENSG00000115318	1.62	1.31	1.53	1.55	1.88	1.71	-0.178625934726551	1.92493368302113	0.33333797247579	0.710095117958123	2:74532413-74555690:-	LOXL3	26;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001968,molecular_function fibronectin binding;GO:0004720,molecular_function protein-lysine 6-oxidase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006954,biological_process inflammatory response;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016641,molecular_function oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0018057,biological_process peptidyl-lysine oxidation;GO:0021510,biological_process spinal cord development;GO:0030324,biological_process lung development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0060021,biological_process palate development;GO:0061053,biological_process somite development;GO:1905590,biological_process fibronectin fibril organization;GO:2000329,biological_process negative regulation of T-helper 17 cell lineage commitment;GO:2001046,biological_process positive regulation of integrin-mediated signaling pathway	NA	lysyl oxidase like 3 [Source:HGNC Symbol%3BAcc:HGNC:13869]
ENSG00000255154	15.83	15.93	12.12	16.94	16.10	15.63	-0.143162136509775	2.98543185087917	0.333491656451567	0.710274911756058	3:58306261-58318574:+	HTD2	8;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0016829,molecular_function lyase activity;GO:0018812,molecular_function 3-hydroxyacyl-CoA dehydratase activity;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process	RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]; K14529	hydroxyacyl-thioester dehydratase type 2 [Source:HGNC Symbol%3BAcc:HGNC:53111]
ENSG00000146094	0.85	0.83	1.08	0.69	1.03	0.54	0.313666151680098	0.752900184556148	0.333536813069045	0.710274911756058	5:177501906-177511274:-	DOK3	8;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	docking protein 3 [Source:HGNC Symbol%3BAcc:HGNC:24583]
ENSG00000133028	37.46	35.77	35.62	39.88	39.14	36.52	-0.0722018888937487	5.08573414318437	0.333778581380423	0.710667844026619	17:10672473-10698375:-	SCO1	13;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006825,biological_process copper ion transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0030016,cellular_component myofibril;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly;GO:0046872,molecular_function metal ion binding;GO:0072492,cellular_component host cell mitochondrial intermembrane space;GO:1901799,biological_process negative regulation of proteasomal protein catabolic process	NA	SCO1%2C cytochrome c oxidase assembly protein [Source:HGNC Symbol%3BAcc:HGNC:10603]
ENSG00000149547	84.52	95.40	82.57	81.78	92.28	76.01	0.0801140585029559	6.61848849715533	0.333973987647187	0.710862558064529	11:125569215-125584687:+	EI24	13;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0030308,biological_process negative regulation of cell growth;GO:0031965,cellular_component nuclear membrane	EI24; etoposide-induced 2.4 mRNA; K10134	EI24%2C autophagy associated transmembrane protein [Source:HGNC Symbol%3BAcc:HGNC:13276]
ENSG00000185483	8.48	6.92	7.53	8.14	7.89	8.66	-0.0885415328035934	4.4974139345036	0.334029891073814	0.710862558064529	1:63774021-64181498:+	ROR1	24;GO:0000166,molecular_function nucleotide binding;GO:0001725,cellular_component stress fiber;GO:0004672,molecular_function protein kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009986,cellular_component cell surface;GO:0014002,biological_process astrocyte development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017147,molecular_function Wnt-protein binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0043235,cellular_component receptor complex;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:1904929,molecular_function coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	ROR1, NTRKR1; receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1]; K05122	receptor tyrosine kinase like orphan receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:10256]
ENSG00000110442	33.77	44.40	38.04	37.56	46.73	41.79	-0.113261784892841	4.58977143554111	0.334041835268702	0.710862558064529	11:36269283-36289449:-	COMMD9	15;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034774,cellular_component secretory granule lumen;GO:0042632,biological_process cholesterol homeostasis;GO:0043312,biological_process neutrophil degranulation;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	COMM domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:25014]
ENSG00000181817	50.91	43.25	46.67	44.23	45.63	43.45	0.0988631688813913	4.09156321522676	0.334120695496922	0.710908500720481	1:36391237-36397892:-	LSM10	15;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005683,cellular_component U7 snRNP;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0071208,molecular_function histone pre-mRNA DCP binding;GO:0071209,molecular_function U7 snRNA binding;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle	NA	LSM10%2C U7 small nuclear RNA associated [Source:HGNC Symbol%3BAcc:HGNC:17562]
ENSG00000100412	55.42	57.85	51.90	49.73	57.78	50.84	0.0718463779292173	7.02668732706469	0.334374573466489	0.711168068532406	22:41469124-41528989:+	ACO2	17;GO:0001889,biological_process liver development;GO:0003994,molecular_function aconitate hydratase activity;GO:0005506,molecular_function iron ion binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006101,biological_process citrate metabolic process;GO:0006102,biological_process isocitrate metabolic process;GO:0008152,biological_process metabolic process;GO:0016829,molecular_function lyase activity;GO:0035900,biological_process response to isolation stress;GO:0043209,cellular_component myelin sheath;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051538,molecular_function 3 iron, 4 sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding	ACO, acnA; aconitate hydratase [EC:4.2.1.3]; K01681	aconitase 2 [Source:HGNC Symbol%3BAcc:HGNC:118]
ENSG00000107223	307.24	302.50	299.99	321.05	309.42	324.37	-0.0580787795326529	7.32190405683827	0.334410392336517	0.711168068532406	9:136862118-136866286:-	EDF1	21;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030154,biological_process cell differentiation;GO:0043388,biological_process positive regulation of DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045446,biological_process endothelial cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0070062,cellular_component extracellular exosome	NA	endothelial differentiation related factor 1 [Source:HGNC Symbol%3BAcc:HGNC:3164]
ENSG00000135220	1.81	2.05	1.67	1.28	1.86	1.59	0.22524214404091	1.54998374565192	0.334443342375488	0.711168068532406	4:68928462-68951791:-	UGT2A3	9;GO:0008152,biological_process metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0052695,biological_process cellular glucuronidation	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 2 member A3 [Source:HGNC Symbol%3BAcc:HGNC:28528]
ENSG00000101751	14.26	13.55	16.36	12.66	12.85	16.08	0.100054929973163	5.05679902842936	0.334471858865076	0.711168068532406	18:54269403-54321266:+	POLI	18;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019985,biological_process translesion synthesis;GO:0042276,biological_process error-prone translesion synthesis;GO:0046872,molecular_function metal ion binding;GO:0071897,biological_process DNA biosynthetic process	POLI; DNA polymerase iota [EC:2.7.7.7]; K03510	DNA polymerase iota [Source:HGNC Symbol%3BAcc:HGNC:9182]
ENSG00000170619	25.22	23.89	26.94	23.62	29.01	29.93	-0.103679820312523	4.16751598012252	0.334675255667929	0.711424329548715	8:144841041-144853736:-	COMMD5	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	COMM domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:17902]
ENSG00000140988	2136.64	2011.27	1997.24	2164.77	2060.56	2222.90	-0.0576297177025047	11.0363210061935	0.334737045675429	0.711424329548715	16:1962051-1964860:-	RPS2	25;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006479,biological_process protein methylation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0017134,molecular_function fibroblast growth factor binding;GO:0019083,biological_process viral transcription;GO:0019899,molecular_function enzyme binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045296,molecular_function cadherin binding;GO:0051347,biological_process positive regulation of transferase activity;GO:0070062,cellular_component extracellular exosome	RP-S2e, RPS2; small subunit ribosomal protein S2e; K02981	ribosomal protein S2 [Source:HGNC Symbol%3BAcc:HGNC:10404]
ENSG00000141086	2.03	1.94	2.37	2.50	2.90	2.27	-0.251204797565576	1.08064169618281	0.334764320381378	0.711424329548715	16:67927639-67932414:-	CTRL	7;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0007586,biological_process digestion;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity	CTRL; chymotrypsin-like protease [EC:3.4.21.-]; K09632	chymotrypsin like [Source:HGNC Symbol%3BAcc:HGNC:2524]
ENSG00000145824	3.82	5.17	4.20	3.60	5.24	1.27	0.3917613840852	0.506028336533755	0.334981045521146	0.711683302727489	5:135570678-135579279:-	CXCL14	14;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0006935,biological_process chemotaxis;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008009,molecular_function chemokine activity;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0048839,biological_process inner ear development;GO:0060326,biological_process cell chemotaxis;GO:2000503,biological_process positive regulation of natural killer cell chemotaxis	CXCL14, SCYB14; C-X-C motif chemokine 14; K10033	C-X-C motif chemokine ligand 14 [Source:HGNC Symbol%3BAcc:HGNC:10640]
ENSG00000171988	13.55	12.51	13.83	14.07	14.21	13.77	-0.062260632149457	6.70725484377638	0.335000848935529	0.711683302727489	10:63167220-63521850:-	JMJD1C	18;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007596,biological_process blood coagulation;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0031490,molecular_function chromatin DNA binding;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0046872,molecular_function metal ion binding;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	JMJD1C; jumonji domain-containing protein 1C [EC:1.14.11.-]; K11449	jumonji domain containing 1C [Source:HGNC Symbol%3BAcc:HGNC:12313]
ENSG00000079215	0.56	0.59	1.22	0.51	0.28	0.99	0.424241555347158	0.368950644413418	0.335202474919165	0.711903503486358	5:36606354-36688334:+	SLC1A3	47;GO:0001504,biological_process neurotransmitter uptake;GO:0005313,molecular_function L-glutamate transmembrane transporter activity;GO:0005314,molecular_function high-affinity glutamate transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006536,biological_process glutamate metabolic process;GO:0006537,biological_process glutamate biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006865,biological_process amino acid transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007605,biological_process sensory perception of sound;GO:0009416,biological_process response to light stimulus;GO:0009449,biological_process gamma-aminobutyric acid biosynthetic process;GO:0009611,biological_process response to wounding;GO:0009986,cellular_component cell surface;GO:0014047,biological_process glutamate secretion;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015172,molecular_function acidic amino acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015501,molecular_function glutamate:sodium symporter activity;GO:0015813,biological_process L-glutamate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016595,molecular_function glutamate binding;GO:0016597,molecular_function amino acid binding;GO:0021545,biological_process cranial nerve development;GO:0031223,biological_process auditory behavior;GO:0042493,biological_process response to drug;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0046677,biological_process response to antibiotic;GO:0046872,molecular_function metal ion binding;GO:0048667,biological_process cell morphogenesis involved in neuron differentiation;GO:0050806,biological_process positive regulation of synaptic transmission;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051938,biological_process L-glutamate import;GO:0055085,biological_process transmembrane transport;GO:0070779,biological_process D-aspartate import;GO:0071805,biological_process potassium ion transmembrane transport;GO:0071944,cellular_component cell periphery;GO:0089711,biological_process L-glutamate transmembrane transport;GO:0098712,biological_process L-glutamate import across plasma membrane;GO:0140009,biological_process L-aspartate import across plasma membrane;GO:0140016,biological_process D-aspartate import across plasma membrane;GO:1902476,biological_process chloride transmembrane transport	SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; K05614	solute carrier family 1 member 3 [Source:HGNC Symbol%3BAcc:HGNC:10941]
ENSG00000081791	18.74	20.78	19.01	20.31	22.78	19.39	-0.0854350228870063	4.96756417196187	0.335219203889291	0.711903503486358	5:141923807-141942047:+	KIAA0141	5;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0043281,biological_process regulation of cysteine-type endopeptidase activity involved in apoptotic process	NA	KIAA0141 [Source:HGNC Symbol%3BAcc:HGNC:28969]
ENSG00000072401	26.74	35.54	32.38	27.16	28.89	31.41	0.11469968920961	3.75306834550999	0.335404897578845	0.712058576424436	10:58334974-58370753:+	UBE2D1	31;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0030509,biological_process BMP signaling pathway;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1902916,biological_process positive regulation of protein polyubiquitination	UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]; K06689	ubiquitin conjugating enzyme E2 D1 [Source:HGNC Symbol%3BAcc:HGNC:12474]
ENSG00000204531	20.90	20.68	20.77	22.29	21.33	22.80	-0.0798119511056557	4.56584679660089	0.335406952094874	0.712058576424436	6:31164336-31180731:-	POU5F1	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001714,biological_process endodermal cell fate specification;GO:0001824,biological_process blastocyst development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009611,biological_process response to wounding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009786,biological_process regulation of asymmetric cell division;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0019955,molecular_function cytokine binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035198,molecular_function miRNA binding;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060965,biological_process negative regulation of gene silencing by miRNA	POU5F; POU domain transcription factor, class 5; K09367	POU class 5 homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:9221]
ENSG00000185467	0.55	0.68	0.33	0.92	0.59	0.55	-0.406734754818168	0.106998212336138	0.335633751224852	0.712418220580385	7:99173573-99207506:-	KPNA7	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0019054,biological_process modulation by virus of host process;GO:0043657,cellular_component host cell;GO:0075733,biological_process intracellular transport of virus	NA	karyopherin subunit alpha 7 [Source:HGNC Symbol%3BAcc:HGNC:21839]
ENSG00000110092	229.35	165.11	241.68	267.42	176.02	264.75	-0.142430250890388	7.63519638449089	0.335778518678515	0.712603650599487	11:69641086-69654474:+	CCND1	72;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0000320,biological_process re-entry into mitotic cell cycle;GO:0001889,biological_process liver development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003714,molecular_function transcription corepressor activity;GO:0004672,molecular_function protein kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005923,cellular_component bicellular tight junction;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007595,biological_process lactation;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010033,biological_process response to organic substance;GO:0010039,biological_process response to iron ion;GO:0010165,biological_process response to X-ray;GO:0010243,biological_process response to organonitrogen compound;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030857,biological_process negative regulation of epithelial cell differentiation;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031100,biological_process organ regeneration;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0032026,biological_process response to magnesium ion;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0033197,biological_process response to vitamin E;GO:0033327,biological_process Leydig cell differentiation;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0042493,biological_process response to drug;GO:0042826,molecular_function histone deacetylase binding;GO:0043627,biological_process response to estrogen;GO:0044321,biological_process response to leptin;GO:0045444,biological_process fat cell differentiation;GO:0045471,biological_process response to ethanol;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045787,biological_process positive regulation of cell cycle;GO:0045859,biological_process regulation of protein kinase activity;GO:0048545,biological_process response to steroid hormone;GO:0051301,biological_process cell division;GO:0051384,biological_process response to glucocorticoid;GO:0051412,biological_process response to corticosterone;GO:0051592,biological_process response to calcium ion;GO:0051726,biological_process regulation of cell cycle;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060749,biological_process mammary gland alveolus development;GO:0070064,molecular_function proline-rich region binding;GO:0070141,biological_process response to UV-A;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071310,biological_process cellular response to organic substance;GO:0097421,biological_process liver regeneration;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A; K06625	cyclin D1 [Source:HGNC Symbol%3BAcc:HGNC:1582]
ENSG00000181904	39.77	39.05	38.39	38.56	46.49	40.65	-0.0880822075751019	4.61732385750504	0.335887126481097	0.712616586724976	5:134845679-134859737:+	C5orf24	1;GO:0005515,molecular_function protein binding	NA	chromosome 5 open reading frame 24 [Source:HGNC Symbol%3BAcc:HGNC:26746]
ENSG00000136522	51.79	50.20	45.04	50.61	51.47	53.91	-0.075093981959988	5.25020782068745	0.335899431960673	0.712616586724976	3:179588284-179604654:-	MRPL47	14;GO:0003674,molecular_function molecular_function;GO:0003735,molecular_function structural constituent of ribosome;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0008150,biological_process biological_process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L47 [Source:HGNC Symbol%3BAcc:HGNC:16652]
ENSG00000184117	85.33	85.98	85.11	89.09	91.96	88.45	-0.060144545188085	6.348000701956	0.335959764490453	0.712622788212576	22:29554807-29581337:-	NIPSNAP1	7;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0019233,biological_process sensory perception of pain;GO:0042165,molecular_function neurotransmitter binding;GO:0097060,cellular_component synaptic membrane	NA	nipsnap homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:7827]
ENSG00000006704	31.98	30.37	33.21	34.63	32.48	33.62	-0.0628515602882714	6.66199681690269	0.33609655953422	0.712728881505336	7:74453789-74602604:+	GTF2IRD1	15;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0014886,biological_process transition between slow and fast fiber	TFII-I, GTF2I; transcription initiation factor TFII-I; K03121	GTF2I repeat domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:4661]
ENSG00000041357	166.40	173.23	166.20	188.94	173.80	170.21	-0.0642623567810217	7.12686898095949	0.336124617121746	0.712728881505336	15:78540404-78552419:+	PSMA4	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019773,cellular_component proteasome core complex, alpha-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMA4; 20S proteasome subunit alpha 3 [EC:3.4.25.1]; K02728	proteasome subunit alpha 4 [Source:HGNC Symbol%3BAcc:HGNC:9533]
ENSG00000100526	75.23	82.21	73.00	81.58	83.56	78.14	-0.0697118725530848	5.86609136242806	0.336182595257247	0.712730069159386	14:54396848-54420218:+	CDKN3	19;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol%3BAcc:HGNC:1791]
ENSG00000267508	1.22	1.28	1.11	1.17	0.89	0.98	0.252665383826529	1.09009172041175	0.33628857326548	0.712833002039686	19:44382297-44401608:-	ZNF285	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 285 [Source:HGNC Symbol%3BAcc:HGNC:13079]
ENSG00000078237	9.42	11.80	8.54	7.67	9.64	9.46	0.148923666162482	2.95044006031803	0.336517652811793	0.713177613210597	12:4307762-4354593:+	TIGAR	35;GO:0002931,biological_process response to ischemia;GO:0003824,molecular_function catalytic activity;GO:0004083,molecular_function bisphosphoglycerate 2-phosphatase activity;GO:0004331,molecular_function fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006003,biological_process fructose 2,6-bisphosphate metabolic process;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0009410,biological_process response to xenobiotic stimulus;GO:0010332,biological_process response to gamma radiation;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030388,biological_process fructose 1,6-bisphosphate metabolic process;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043456,biological_process regulation of pentose-phosphate shunt;GO:0045739,biological_process positive regulation of DNA repair;GO:0045820,biological_process negative regulation of glycolytic process;GO:0060576,biological_process intestinal epithelial cell development;GO:0071279,biological_process cellular response to cobalt ion;GO:0071456,biological_process cellular response to hypoxia;GO:1901215,biological_process negative regulation of neuron death;GO:1901525,biological_process negative regulation of macromitophagy;GO:1902153,biological_process regulation of response to DNA damage checkpoint signaling;GO:1903301,biological_process positive regulation of hexokinase activity;GO:1904024,biological_process negative regulation of glucose catabolic process to lactate via pyruvate;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	TIGAR; fructose-2,6-bisphosphatase [EC:3.1.3.46]; K14634	TP53 induced glycolysis regulatory phosphatase [Source:HGNC Symbol%3BAcc:HGNC:1185]
ENSG00000196689	2.66	2.40	3.26	2.38	2.50	2.70	0.154886012200292	2.7941371268337	0.33659498392189	0.713177613210597	17:3565443-3609411:-	TRPV1	84;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0001659,biological_process temperature homeostasis;GO:0001660,biological_process fever generation;GO:0001774,biological_process microglial cell activation;GO:0002024,biological_process diet induced thermogenesis;GO:0002790,biological_process peptide secretion;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005231,molecular_function excitatory extracellular ligand-gated ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006954,biological_process inflammatory response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007635,biological_process chemosensory behavior;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0009268,biological_process response to pH;GO:0009408,biological_process response to heat;GO:0009897,cellular_component external side of plasma membrane;GO:0010243,biological_process response to organonitrogen compound;GO:0014047,biological_process glutamate secretion;GO:0014832,biological_process urinary bladder smooth muscle contraction;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017081,molecular_function chloride channel regulator activity;GO:0019233,biological_process sensory perception of pain;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0032591,cellular_component dendritic spine membrane;GO:0034220,biological_process ion transmembrane transport;GO:0034605,biological_process cellular response to heat;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043434,biological_process response to peptide hormone;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0048265,biological_process response to pain;GO:0048266,biological_process behavioral response to pain;GO:0050954,biological_process sensory perception of mechanical stimulus;GO:0050955,biological_process thermoception;GO:0050960,biological_process detection of temperature stimulus involved in thermoception;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain;GO:0050968,biological_process detection of chemical stimulus involved in sensory perception of pain;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051219,molecular_function phosphoprotein binding;GO:0051289,biological_process protein homotetramerization;GO:0055085,biological_process transmembrane transport;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060083,biological_process smooth muscle contraction involved in micturition;GO:0060454,biological_process positive regulation of gastric acid secretion;GO:0065009,biological_process regulation of molecular function;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071312,biological_process cellular response to alkaloid;GO:0071318,biological_process cellular response to ATP;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071468,biological_process cellular response to acidic pH;GO:0071502,biological_process cellular response to temperature stimulus;GO:0090212,biological_process negative regulation of establishment of blood-brain barrier;GO:0097603,molecular_function temperature-gated ion channel activity;GO:0098703,biological_process calcium ion import across plasma membrane;GO:1901594,biological_process response to capsazepine;GO:1990090,biological_process cellular response to nerve growth factor stimulus	TRPV1; transient receptor potential cation channel subfamily V member 1; K05222	transient receptor potential cation channel subfamily V member 1 [Source:HGNC Symbol%3BAcc:HGNC:12716]
ENSG00000173456	32.08	35.90	28.73	34.53	35.32	33.13	-0.0838821697890779	5.43763892216593	0.336755207335667	0.713177613210597	11:119334526-119337313:+	RNF26	15;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007032,biological_process endosome organization;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032479,biological_process regulation of type I interferon production;GO:0046872,molecular_function metal ion binding;GO:0050687,biological_process negative regulation of defense response to virus;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070979,biological_process protein K11-linked ubiquitination;GO:1905719,biological_process protein localization to perinuclear region of cytoplasm	NA	ring finger protein 26 [Source:HGNC Symbol%3BAcc:HGNC:14646]
ENSG00000142207	6.03	6.21	5.87	6.30	5.74	5.25	0.077726651411802	5.33408391020886	0.336784894893515	0.713177613210597	21:32311017-32393026:-	URB1	5;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008150,biological_process biological_process	NA	URB1 ribosome biogenesis 1 homolog (S. cerevisiae) [Source:HGNC Symbol%3BAcc:HGNC:17344]
ENSG00000113924	45.43	48.87	46.32	42.02	49.78	42.81	0.0734721339696584	5.9713916363254	0.336956678484795	0.713177613210597	3:120628172-120682571:-	HGD	13;GO:0004411,molecular_function homogentisate 1,2-dioxygenase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0006570,biological_process tyrosine metabolic process;GO:0006572,biological_process tyrosine catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	HGD, hmgA; homogentisate 1,2-dioxygenase [EC:1.13.11.5]; K00451	homogentisate 1%2C2-dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:4892]
ENSG00000185798	9.18	9.05	9.84	10.64	9.44	10.58	-0.113406010905645	3.42231057793885	0.336959424751255	0.713177613210597	3:196554176-196568674:-	WDR53	1;GO:0005737,cellular_component cytoplasm	NA	WD repeat domain 53 [Source:HGNC Symbol%3BAcc:HGNC:28786]
ENSG00000105717	5.29	4.34	6.17	5.34	5.07	3.70	0.190204092988337	2.52656589213449	0.336983930266986	0.713177613210597	19:19561706-19618916:-	PBX4	10;GO:0001741,cellular_component XY body;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	PBX homeobox 4 [Source:HGNC Symbol%3BAcc:HGNC:13403]
ENSG00000188976	54.34	50.44	52.18	58.41	51.51	55.77	-0.0654177805820728	6.92018276111536	0.337049257731169	0.713177613210597	1:944203-959309:-	NOC2L	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002903,biological_process negative regulation of B cell apoptotic process;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0030690,cellular_component Noc1p-Noc2p complex;GO:0030691,cellular_component Noc2p-Noc3p complex;GO:0031491,molecular_function nucleosome binding;GO:0031497,biological_process chromatin assembly;GO:0034644,biological_process cellular response to UV;GO:0035067,biological_process negative regulation of histone acetylation;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0042393,molecular_function histone binding;GO:0070491,molecular_function repressing transcription factor binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	NA	NOC2 like nucleolar associated transcriptional repressor [Source:HGNC Symbol%3BAcc:HGNC:24517]
ENSG00000104738	52.57	62.49	51.74	61.48	58.30	57.31	-0.0765398872480772	7.21457319421282	0.337157417737001	0.713177613210597	8:47960184-47978160:+	MCM4	19;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003697,molecular_function single-stranded DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0042555,cellular_component MCM complex	MCM4, CDC54; DNA replication licensing factor MCM4 [EC:3.6.4.12]; K02212	minichromosome maintenance complex component 4 [Source:HGNC Symbol%3BAcc:HGNC:6947]
ENSG00000029534	0.06	0.17	0.16	0.20	0.17	0.15	-0.451700259171281	0.0901342766008724	0.33717176874257	0.713177613210597	8:41653219-41896762:-	ANK1	30;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0010638,biological_process positive regulation of organelle organization;GO:0014731,cellular_component spectrin-associated cytoskeleton;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0019899,molecular_function enzyme binding;GO:0030018,cellular_component Z disc;GO:0030507,molecular_function spectrin binding;GO:0030673,cellular_component axolemma;GO:0031430,cellular_component M band;GO:0031672,cellular_component A band;GO:0042383,cellular_component sarcolemma;GO:0043005,cellular_component neuron projection;GO:0045199,biological_process maintenance of epithelial cell apical/basal polarity;GO:0045211,cellular_component postsynaptic membrane;GO:0051117,molecular_function ATPase binding;GO:0072661,biological_process protein targeting to plasma membrane	ANK; ankyrin; K10380	ankyrin 1 [Source:HGNC Symbol%3BAcc:HGNC:492]
ENSG00000139405	20.06	18.14	18.32	17.87	18.10	17.58	0.0941069453318722	4.02785023709074	0.337173483076426	0.713177613210597	12:113185525-113192368:+	RITA1	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007219,biological_process Notch signaling pathway;GO:0007399,biological_process nervous system development;GO:0015631,molecular_function tubulin binding;GO:0022008,biological_process neurogenesis;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0051168,biological_process nuclear export	NA	RBPJ interacting and tubulin associated 1 [Source:HGNC Symbol%3BAcc:HGNC:25925]
ENSG00000168303	81.15	80.62	70.86	76.68	81.63	89.17	-0.0800242651692232	5.4312586998773	0.337232821425536	0.713177613210597	7:40126022-40134659:-	MPLKIP	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0030496,cellular_component midbody;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051301,biological_process cell division	NA	M-phase specific PLK1 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16002]
ENSG00000128951	92.96	92.71	85.79	91.99	94.64	99.32	-0.0643358493704756	6.44557364561501	0.337342213424861	0.713177613210597	15:48331010-48343373:+	DUT	16;GO:0000287,molecular_function magnesium ion binding;GO:0003723,molecular_function RNA binding;GO:0004170,molecular_function dUTP diphosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006226,biological_process dUMP biosynthetic process;GO:0006260,biological_process DNA replication;GO:0009117,biological_process nucleotide metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016787,molecular_function hydrolase activity;GO:0046080,biological_process dUTP metabolic process;GO:0046081,biological_process dUTP catabolic process;GO:0070062,cellular_component extracellular exosome	dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]; K01520	deoxyuridine triphosphatase [Source:HGNC Symbol%3BAcc:HGNC:3078]
ENSG00000136828	0.80	0.56	0.67	0.99	0.79	0.73	-0.268455939877111	0.876452268650297	0.337358862396918	0.713177613210597	9:126914773-127223166:+	RALGPS1	11;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008321,molecular_function Ral guanyl-nucleotide exchange factor activity;GO:0016020,cellular_component membrane;GO:0032485,biological_process regulation of Ral protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	Ral GEF with PH domain and SH3 binding motif 1 [Source:HGNC Symbol%3BAcc:HGNC:16851]
ENSG00000140395	32.86	33.07	31.94	30.37	31.51	32.03	0.0699173099018131	5.03803675648479	0.337436645043517	0.713177613210597	15:78277834-78299794:-	WDR61	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0035327,cellular_component transcriptionally active chromatin;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0055087,cellular_component Ski complex;GO:0080182,biological_process histone H3-K4 trimethylation;GO:2001162,biological_process positive regulation of histone H3-K79 methylation	WDR61, REC14, SKI8; WD repeat-containing protein 61; K12602	WD repeat domain 61 [Source:HGNC Symbol%3BAcc:HGNC:30300]
ENSG00000196550	9.22	9.28	10.72	12.61	9.67	10.56	-0.153388587131297	2.80502916658564	0.33745260579699	0.713177613210597	1:206186178-206204414:-	FAM72A	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	family with sequence similarity 72 member A [Source:HGNC Symbol%3BAcc:HGNC:24044]
ENSG00000215009	4.75	3.30	4.10	4.86	3.88	4.93	-0.145212529030673	2.94645004935023	0.33755125893324	0.713177613210597	12:7304283-7328724:+	ACSM4	16;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003996,molecular_function acyl-CoA ligase activity;GO:0004321,molecular_function fatty-acyl-CoA synthase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008152,biological_process metabolic process;GO:0015645,molecular_function fatty acid ligase activity;GO:0016874,molecular_function ligase activity;GO:0046872,molecular_function metal ion binding;GO:0047760,molecular_function butyrate-CoA ligase activity	ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]; K01896	acyl-CoA synthetase medium chain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:32016]
ENSG00000136485	37.72	37.91	36.80	38.90	42.36	37.83	-0.071117563101358	5.31328016751935	0.337566814553987	0.713177613210597	17:63550460-63594266:+	DCAF7	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0016363,cellular_component nuclear matrix;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0043234,cellular_component protein complex;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 7 [Source:HGNC Symbol%3BAcc:HGNC:30915]
ENSG00000177156	266.57	282.12	252.62	247.70	269.51	255.89	0.0629121166987538	8.12658048739572	0.337574404410561	0.713177613210597	11:747328-765024:+	TALDO1	18;GO:0003824,molecular_function catalytic activity;GO:0004801,molecular_function sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005999,biological_process xylulose biosynthetic process;GO:0006002,biological_process fructose 6-phosphate metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0009052,biological_process pentose-phosphate shunt, non-oxidative branch;GO:0016740,molecular_function transferase activity;GO:0019682,biological_process glyceraldehyde-3-phosphate metabolic process;GO:0030246,molecular_function carbohydrate binding;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048029,molecular_function monosaccharide binding;GO:0070062,cellular_component extracellular exosome	E2.2.1.2, talA, talB; transaldolase [EC:2.2.1.2]; K00616	transaldolase 1 [Source:HGNC Symbol%3BAcc:HGNC:11559]
ENSG00000130762	4.69	4.02	5.37	4.04	4.43	4.57	0.131273404071996	3.38017218030096	0.337635370294379	0.713177613210597	1:3454425-3481113:+	ARHGEF16	16;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0017048,molecular_function Rho GTPase binding;GO:0030165,molecular_function PDZ domain binding;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0060326,biological_process cell chemotaxis;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0090630,biological_process activation of GTPase activity	NA	Rho guanine nucleotide exchange factor 16 [Source:HGNC Symbol%3BAcc:HGNC:15515]
ENSG00000175390	168.47	173.42	167.06	155.88	166.46	169.98	0.0592671368108538	7.59863156536213	0.33765768410849	0.713177613210597	11:7970250-8001862:+	EIF3F	18;GO:0003743,molecular_function translation initiation factor activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0031369,molecular_function translation initiation factor binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0071541,cellular_component eukaryotic translation initiation factor 3 complex, eIF3m;GO:0075522,biological_process IRES-dependent viral translational initiation	EIF3F; translation initiation factor 3 subunit F; K03249	eukaryotic translation initiation factor 3 subunit F [Source:HGNC Symbol%3BAcc:HGNC:3275]
ENSG00000000003	35.07	37.53	35.16	40.92	39.51	34.73	-0.085906645211525	4.79042105858696	0.337877321843801	0.713520108208082	X:100627108-100639991:-	TSPAN6	10;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0039532,biological_process negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0070062,cellular_component extracellular exosome;GO:1901223,biological_process negative regulation of NIK/NF-kappaB signaling	NA	tetraspanin 6 [Source:HGNC Symbol%3BAcc:HGNC:11858]
ENSG00000164347	11.52	11.23	10.27	11.84	11.44	11.86	-0.0794406349729737	4.75749489748537	0.337939687482977	0.713530420263003	5:74721203-74767371:-	GFM2	12;GO:0000166,molecular_function nucleotide binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0032543,biological_process mitochondrial translation;GO:0032790,biological_process ribosome disassembly;GO:0070126,biological_process mitochondrial translational termination	NA	G elongation factor mitochondrial 2 [Source:HGNC Symbol%3BAcc:HGNC:29682]
ENSG00000123411	1.88	1.59	2.25	1.87	2.44	2.30	-0.183044729756529	1.95794476379088	0.338015728876992	0.713569599073146	12:56007658-56038435:+	IKZF4	21;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016604,cellular_component nuclear body;GO:0019904,molecular_function protein domain specific binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization	NA	IKAROS family zinc finger 4 [Source:HGNC Symbol%3BAcc:HGNC:13179]
ENSG00000111325	10.96	9.26	10.27	9.62	8.67	10.25	0.113596085259704	3.66412036087564	0.338438888572026	0.71434142558146	12:122974579-122980043:+	OGFOD2	7;GO:0005506,molecular_function iron ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0031418,molecular_function L-ascorbic acid binding;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	2-oxoglutarate and iron dependent oxygenase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25823]
ENSG00000158122	18.06	18.43	17.24	20.22	21.56	16.88	-0.114202520582018	3.72885140932555	0.338523628382695	0.714398809778033	9:96639576-96655303:-	AAED1	3;GO:0016209,molecular_function antioxidant activity;GO:0055114,biological_process oxidation-reduction process;GO:0098869,biological_process cellular oxidant detoxification	NA	AhpC/TSA antioxidant enzyme domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16881]
ENSG00000179403	4.17	4.33	3.24	2.52	4.64	3.04	0.211400417816192	2.44401544188443	0.338668546719618	0.714583149826725	1:1434860-1442882:+	VWA1	12;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005614,cellular_component interstitial matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0030198,biological_process extracellular matrix organization;GO:0042802,molecular_function identical protein binding;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048266,biological_process behavioral response to pain;GO:0070062,cellular_component extracellular exosome	NA	von Willebrand factor A domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30910]
ENSG00000100888	18.39	18.95	17.65	17.08	18.39	17.65	0.0608881158145335	7.14952825765975	0.338751167360983	0.714620991112875	14:21385193-21456126:-	CHD8	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0001701,biological_process in utero embryonic development;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003682,molecular_function chromatin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007420,biological_process brain development;GO:0008013,molecular_function beta-catenin binding;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0016055,biological_process Wnt signaling pathway;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0032508,biological_process DNA duplex unwinding;GO:0035064,molecular_function methylated histone binding;GO:0042393,molecular_function histone binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0048565,biological_process digestive tract development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0070016,molecular_function armadillo repeat domain binding;GO:0071339,cellular_component MLL1 complex;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000270,biological_process negative regulation of fibroblast apoptotic process	CHD8, HELSNF1; chromodomain helicase DNA binding protein 8 [EC:3.6.4.12]; K04494	chromodomain helicase DNA binding protein 8 [Source:HGNC Symbol%3BAcc:HGNC:20153]
ENSG00000197299	2.37	2.34	2.31	2.41	2.41	2.84	-0.117216349957284	3.45422753538688	0.338801621904396	0.714620991112875	15:90717326-90816165:+	BLM	71;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000166,molecular_function nucleotide binding;GO:0000228,cellular_component nuclear chromosome;GO:0000400,molecular_function four-way junction DNA binding;GO:0000403,molecular_function Y-form DNA binding;GO:0000405,molecular_function bubble DNA binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000733,biological_process DNA strand renaturation;GO:0000781,cellular_component chromosome, telomeric region;GO:0000800,cellular_component lateral element;GO:0002039,molecular_function p53 binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003697,molecular_function single-stranded DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008270,molecular_function zinc ion binding;GO:0009378,molecular_function four-way junction helicase activity;GO:0010165,biological_process response to X-ray;GO:0016363,cellular_component nuclear matrix;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0016887,molecular_function ATPase activity;GO:0031297,biological_process replication fork processing;GO:0032508,biological_process DNA duplex unwinding;GO:0035786,biological_process protein complex oligomerization;GO:0036310,molecular_function annealing helicase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043140,molecular_function ATP-dependent 3'-5' DNA helicase activity;GO:0044237,biological_process cellular metabolic process;GO:0044806,biological_process G-quadruplex DNA unwinding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045910,biological_process negative regulation of DNA recombination;GO:0048478,biological_process replication fork protection;GO:0051259,biological_process protein oligomerization;GO:0051260,biological_process protein homooligomerization;GO:0051782,biological_process negative regulation of cell division;GO:0051880,molecular_function G-quadruplex DNA binding;GO:0061749,molecular_function forked DNA-dependent helicase activity;GO:0061820,biological_process telomeric D-loop disassembly;GO:0061821,molecular_function telomeric D-loop binding;GO:0061849,molecular_function telomeric G-quadruplex DNA binding;GO:0071479,biological_process cellular response to ionizing radiation;GO:0072711,biological_process cellular response to hydroxyurea;GO:0072757,biological_process cellular response to camptothecin;GO:0090329,biological_process regulation of DNA-dependent DNA replication;GO:0090656,biological_process t-circle formation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1905773,molecular_function 8-hydroxy-2'-deoxyguanosine DNA binding	BLM, RECQL3, SGS1; bloom syndrome protein [EC:3.6.4.12]; K10901	Bloom syndrome RecQ like helicase [Source:HGNC Symbol%3BAcc:HGNC:1058]
ENSG00000147789	16.42	16.39	17.43	17.29	16.95	18.95	-0.0702750931999159	5.46045853745192	0.33888689116197	0.714679405367573	8:144827463-144847509:+	ZNF7	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 7 [Source:HGNC Symbol%3BAcc:HGNC:13139]
ENSG00000167315	20.04	20.02	21.07	22.06	21.33	21.66	-0.076724477858289	4.66574834475773	0.339095902359134	0.714892080899322	18:49782166-49813960:-	ACAA2	19;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0003988,molecular_function acetyl-CoA C-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia;GO:1901029,biological_process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1902109,biological_process negative regulation of mitochondrial membrane permeability involved in apoptotic process	ACAA2; acetyl-CoA acyltransferase 2 [EC:2.3.1.16]; K07508	acetyl-CoA acyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:83]
ENSG00000169733	21.19	16.94	19.49	18.40	16.34	19.47	0.10668773128612	4.22743769634143	0.339150640386607	0.714892080899322	17:82047901-82051831:-	RFNG	19;GO:0000139,cellular_component Golgi membrane;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0007399,biological_process nervous system development;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030154,biological_process cell differentiation;GO:0030173,cellular_component integral component of Golgi membrane;GO:0032092,biological_process positive regulation of protein binding;GO:0033829,molecular_function O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	FNG; fringe [EC:2.4.1.222]; K05948	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:HGNC Symbol%3BAcc:HGNC:9974]
ENSG00000171310	15.85	14.03	18.42	16.87	17.30	18.25	-0.0985135916004262	4.2024450735343	0.339160514333047	0.714892080899322	12:104455294-104762014:+	CHST11	27;GO:0000139,cellular_component Golgi membrane;GO:0001537,molecular_function N-acetylgalactosamine 4-O-sulfotransferase activity;GO:0002063,biological_process chondrocyte development;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0007585,biological_process respiratory gaseous exchange;GO:0008146,molecular_function sulfotransferase activity;GO:0009791,biological_process post-embryonic development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016051,biological_process carbohydrate biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0030204,biological_process chondroitin sulfate metabolic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0033037,biological_process polysaccharide localization;GO:0036342,biological_process post-anal tail morphogenesis;GO:0042127,biological_process regulation of cell proliferation;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0047756,molecular_function chondroitin 4-sulfotransferase activity;GO:0048589,biological_process developmental growth;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0050659,molecular_function N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity;GO:0051216,biological_process cartilage development	CHST11; chondroitin 4-sulfotransferase 11 [EC:2.8.2.5]; K01017	carbohydrate sulfotransferase 11 [Source:HGNC Symbol%3BAcc:HGNC:17422]
ENSG00000243725	17.58	16.63	19.21	19.86	16.79	21.08	-0.0978799862796177	4.44146926287966	0.339225061224365	0.714906737687273	1:54715821-54742657:+	TTC4	NA	NA	tetratricopeptide repeat domain 4 [Source:HGNC Symbol%3BAcc:HGNC:12394]
ENSG00000106733	61.45	62.36	70.26	64.44	61.01	60.52	0.0750138301388164	5.34545579925313	0.339305456726623	0.714954784306157	9:75060572-75088217:-	NMRK1	13;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0009435,biological_process NAD biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0019674,biological_process NAD metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050262,molecular_function ribosylnicotinamide kinase activity;GO:0061769,molecular_function ribosylnicotinate kinase activity	NRK1_2; nicotinamide/nicotinate riboside kinase [EC:2.7.1.22 2.7.1.173]; K10524	nicotinamide riboside kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:26057]
ENSG00000100503	11.10	11.73	10.15	10.89	12.59	11.49	-0.0742785940225638	6.22887425252892	0.339433315852657	0.71510280883894	14:50719762-50831121:-	NIN	20;GO:0000166,molecular_function nucleotide binding;GO:0000242,cellular_component pericentriolar material;GO:0000922,cellular_component spindle pole;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0034454,biological_process microtubule anchoring at centrosome;GO:0036449,cellular_component microtubule minus-end;GO:0051642,biological_process centrosome localization;GO:0090222,biological_process centrosome-templated microtubule nucleation;GO:0097431,cellular_component mitotic spindle pole;GO:0097539,cellular_component ciliary transition fiber	NA	ninein [Source:HGNC Symbol%3BAcc:HGNC:14906]
ENSG00000174032	16.09	18.96	16.36	15.79	17.63	14.43	0.109002952556501	3.87602949731797	0.339631745170605	0.715399432004534	13:45393315-45418455:-	SLC25A30	11;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0031966,cellular_component mitochondrial membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 30 [Source:HGNC Symbol%3BAcc:HGNC:27371]
ENSG00000145743	5.99	5.25	5.57	5.50	6.27	6.52	-0.104977685466123	3.75562306439251	0.339739432582263	0.715504848429526	5:107859034-108382098:-	FBXL17	NA	NA	F-box and leucine rich repeat protein 17 [Source:HGNC Symbol%3BAcc:HGNC:13615]
ENSG00000101782	26.91	25.19	29.31	25.14	24.12	28.47	0.0805324328616089	5.4461044483827	0.339959241897942	0.715816024612201	18:23452822-23486603:+	RIOK3	28;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0007059,biological_process chromosome segregation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030688,cellular_component preribosome, small subunit precursor;GO:0032463,biological_process negative regulation of protein homooligomerization;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0039534,biological_process negative regulation of MDA-5 signaling pathway;GO:0042254,biological_process ribosome biogenesis;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0071359,biological_process cellular response to dsRNA;GO:0089720,molecular_function caspase binding;GO:0098586,biological_process cellular response to virus;GO:1990786,biological_process cellular response to dsDNA	NA	RIO kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:11451]
ENSG00000099992	7.32	6.12	7.17	7.67	7.15	7.73	-0.107938097209788	3.54325135679563	0.340016066671159	0.715816024612201	22:30291989-30327046:-	TBC1D10A	20;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0030165,molecular_function PDZ domain binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0045862,biological_process positive regulation of proteolysis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0090630,biological_process activation of GTPase activity;GO:0097202,biological_process activation of cysteine-type endopeptidase activity	NA	TBC1 domain family member 10A [Source:HGNC Symbol%3BAcc:HGNC:23609]
ENSG00000243955	2.55	5.02	1.88	1.69	3.87	1.69	0.366467042484236	0.957917592854591	0.340060186670277	0.715816024612201	6:52791663-52803910:-	GSTA1	12;GO:0004364,molecular_function glutathione transferase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0030855,biological_process epithelial cell differentiation;GO:0043651,biological_process linoleic acid metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:4626]
ENSG00000185869	1.19	0.81	1.00	1.31	1.13	1.23	-0.256850354261226	0.915440855136105	0.340140890466945	0.715841595198454	19:36888123-36916291:-	ZNF829	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 829 [Source:HGNC Symbol%3BAcc:HGNC:34032]
ENSG00000231500	2589.92	2358.54	2446.59	2750.40	2367.08	2693.99	-0.0672140930920274	10.1755879054205	0.340187671801795	0.715841595198454	6:33272009-33276510:+	RPS18	26;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005581,cellular_component collagen trimer;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0042254,biological_process ribosome biogenesis;GO:0070062,cellular_component extracellular exosome	RP-S18e, RPS18; small subunit ribosomal protein S18e; K02964	ribosomal protein S18 [Source:HGNC Symbol%3BAcc:HGNC:10401]
ENSG00000177042	21.79	19.96	24.59	22.07	20.83	19.84	0.0992718378449261	4.35619603007461	0.340325083299394	0.715931602835286	11:695427-705028:+	TMEM80	4;GO:0005929,cellular_component cilium;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042995,cellular_component cell projection	NA	transmembrane protein 80 [Source:HGNC Symbol%3BAcc:HGNC:27453]
ENSG00000170092	1.02	1.23	1.24	1.86	1.10	1.35	-0.30037276105034	0.826511938462879	0.340365877961726	0.715931602835286	7:75493624-75504304:+	SPDYE5	NA	NA	speedy/RINGO cell cycle regulator family member E5 [Source:HGNC Symbol%3BAcc:HGNC:35464]
ENSG00000132635	22.71	23.72	23.24	22.81	22.33	21.63	0.0713279692427126	4.95944389910486	0.340403473772163	0.715931602835286	20:2835313-2841190:-	PCED1A	1;GO:0005515,molecular_function protein binding	NA	PC-esterase domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:16212]
ENSG00000161267	0.85	0.74	1.20	0.58	0.72	0.90	0.362426816103292	0.172639596931868	0.340559350524709	0.716138102331563	3:197509782-197573323:-	BDH1	13;GO:0003824,molecular_function catalytic activity;GO:0003858,molecular_function 3-hydroxybutyrate dehydrogenase activity;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0046951,biological_process ketone body biosynthetic process;GO:0046952,biological_process ketone body catabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0099617,cellular_component matrix side of mitochondrial inner membrane	E1.1.1.30, bdh; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]; K00019	3-hydroxybutyrate dehydrogenase 1 [Source:HGNC Symbol%3BAcc:HGNC:1027]
ENSG00000139651	33.06	26.08	33.81	31.42	34.06	35.58	-0.099068587821114	4.24610555437167	0.340735471763938	0.716387095360054	12:53180699-53195141:+	ZNF740	5;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 740 [Source:HGNC Symbol%3BAcc:HGNC:27465]
ENSG00000139354	11.67	12.26	11.24	11.69	14.06	11.96	-0.0907872256734494	4.66856519813606	0.340882862264684	0.71640895362433	12:100573682-100628286:+	GAS2L3	10;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0015629,cellular_component actin cytoskeleton;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030036,biological_process actin cytoskeleton organization	NA	growth arrest specific 2 like 3 [Source:HGNC Symbol%3BAcc:HGNC:27475]
ENSG00000179630	1.59	1.93	1.65	2.55	1.88	1.69	-0.241617383425376	1.36311452288131	0.340901959708331	0.71640895362433	13:43879283-43893932:+	LACC1	3;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome	NA	laccase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26789]
ENSG00000128016	15.28	13.04	16.16	15.11	12.79	13.96	0.106654435481397	4.17284931395279	0.340919011444366	0.71640895362433	19:39406812-39409412:+	ZFP36	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0009611,biological_process response to wounding;GO:0017091,molecular_function AU-rich element binding;GO:0030014,cellular_component CCR4-NOT complex;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0035556,biological_process intracellular signal transduction;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0038066,biological_process p38MAPK cascade;GO:0043488,biological_process regulation of mRNA stability;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045085,biological_process negative regulation of interleukin-2 biosynthetic process;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050779,biological_process RNA destabilization;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0070063,molecular_function RNA polymerase binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071889,molecular_function 14-3-3 protein binding;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1904246,biological_process negative regulation of polynucleotide adenylyltransferase activity;GO:1990904,cellular_component ribonucleoprotein complex	TTP; tristetraprolin; K15308	ZFP36 ring finger protein [Source:HGNC Symbol%3BAcc:HGNC:12862]
ENSG00000137103	7.76	9.43	9.78	8.55	8.38	8.21	0.108204110362463	3.81858396969003	0.341006273772277	0.716443542321714	9:35814450-35865518:+	TMEM8B	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0040008,biological_process regulation of growth	NA	transmembrane protein 8B [Source:HGNC Symbol%3BAcc:HGNC:21427]
ENSG00000166595	73.61	86.48	78.53	84.49	82.65	85.30	-0.074956497729785	5.54269984247915	0.341050905629502	0.716443542321714	16:66932054-66934423:-	FAM96B	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007059,biological_process chromosome segregation;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0071817,cellular_component MMXD complex;GO:0097361,cellular_component CIA complex	NA	family with sequence similarity 96 member B [Source:HGNC Symbol%3BAcc:HGNC:24261]
ENSG00000184083	2.82	2.78	3.45	3.22	3.51	3.24	-0.120717650548301	3.41369497610748	0.341140974266414	0.716511491297631	X:54068323-54183281:-	FAM120C	2;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus	NA	family with sequence similarity 120C [Source:HGNC Symbol%3BAcc:HGNC:16949]
ENSG00000263513	6.16	9.83	7.08	8.21	5.77	5.66	0.222004665253692	1.71666727960569	0.341473869874356	0.71708934981397	1:143955363-143971965:-	FAM72C	2;GO:0005829,cellular_component cytosol;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	family with sequence similarity 72 member C [Source:HGNC Symbol%3BAcc:HGNC:30602]
ENSG00000132522	45.93	45.06	41.58	44.70	47.77	47.48	-0.0673540728165571	5.67915140476295	0.34163706067236	0.717242265365687	17:7311323-7315564:-	GPS2	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000188,biological_process inactivation of MAPK activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0007254,biological_process JNK cascade;GO:0017053,cellular_component transcriptional repressor complex;GO:0034260,biological_process negative regulation of GTPase activity;GO:0046329,biological_process negative regulation of JNK cascade	GPS2; G protein pathway suppressor 2; K15307	G protein pathway suppressor 2 [Source:HGNC Symbol%3BAcc:HGNC:4550]
ENSG00000172943	7.84	7.21	6.92	6.88	7.24	6.81	0.0835319319491128	4.6110692833857	0.341815471978592	0.717242265365687	X:53936675-54048958:-	PHF8	32;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003682,molecular_function chromatin binding;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007420,biological_process brain development;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0031965,cellular_component nuclear membrane;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0035064,molecular_function methylated histone binding;GO:0035574,biological_process histone H4-K20 demethylation;GO:0035575,molecular_function histone demethylase activity (H4-K20 specific);GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0061188,biological_process negative regulation of chromatin silencing at rDNA;GO:0070544,biological_process histone H3-K36 demethylation;GO:0071557,biological_process histone H3-K27 demethylation;GO:0071558,molecular_function histone demethylase activity (H3-K27 specific)	NA	PHD finger protein 8 [Source:HGNC Symbol%3BAcc:HGNC:20672]
ENSG00000128342	34.03	35.80	38.62	37.31	32.41	32.95	0.0908952516516697	4.42458133321287	0.341820984849048	0.717242265365687	22:30240446-30246851:-	LIF	47;GO:0001135,molecular_function transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0001974,biological_process blood vessel remodeling;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005146,molecular_function leukemia inhibitory factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0006955,biological_process immune response;GO:0007260,biological_process tyrosine phosphorylation of STAT protein;GO:0007275,biological_process multicellular organism development;GO:0007566,biological_process embryo implantation;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0019827,biological_process stem cell population maintenance;GO:0030324,biological_process lung development;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033141,biological_process positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045595,biological_process regulation of cell differentiation;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045835,biological_process negative regulation of meiotic nuclear division;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046697,biological_process decidualization;GO:0046888,biological_process negative regulation of hormone secretion;GO:0048286,biological_process lung alveolus development;GO:0048644,biological_process muscle organ morphogenesis;GO:0048666,biological_process neuron development;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0048861,biological_process leukemia inhibitory factor signaling pathway;GO:0048863,biological_process stem cell differentiation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0060426,biological_process lung vasculature development;GO:0060463,biological_process lung lobe morphogenesis;GO:0060707,biological_process trophoblast giant cell differentiation;GO:0060708,biological_process spongiotrophoblast differentiation;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0072108,biological_process positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072307,biological_process regulation of metanephric nephron tubule epithelial cell differentiation;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901676,biological_process positive regulation of histone H3-K27 acetylation;GO:1903025,biological_process regulation of RNA polymerase II regulatory region sequence-specific DNA binding	LIF; leukemia inhibitory factor; K05419	LIF%2C interleukin 6 family cytokine [Source:HGNC Symbol%3BAcc:HGNC:6596]
ENSG00000114942	399.38	392.67	380.81	425.09	394.66	410.87	-0.0576841196199534	8.14743646915103	0.341828648354893	0.717242265365687	2:206159584-206162928:+	EEF1B2	9;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005853,cellular_component eukaryotic translation elongation factor 1 complex;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0045471,biological_process response to ethanol	NA	eukaryotic translation elongation factor 1 beta 2 [Source:HGNC Symbol%3BAcc:HGNC:3208]
ENSG00000100294	10.99	12.09	9.60	11.31	12.56	11.54	-0.111733181692535	3.89980252967375	0.341835595094128	0.717242265365687	22:43132205-43143394:-	MCAT	11;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004314,molecular_function [acyl-carrier-protein] S-malonyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity	fabD, MCAT, MCT1; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]; K00645	malonyl-CoA-acyl carrier protein transacylase [Source:HGNC Symbol%3BAcc:HGNC:29622]
ENSG00000162755	2.45	3.77	2.14	2.60	2.70	1.72	0.241021045346191	1.50103389342912	0.341905577509777	0.717267861015526	1:161098360-161100346:+	KLHDC9	NA	NA	kelch domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:28489]
ENSG00000123595	61.02	58.64	53.46	54.26	54.59	56.91	0.0734097052727355	5.09661217976645	0.341999645277082	0.71734396702001	X:13689124-13710506:+	RAB9A	30;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030133,cellular_component transport vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0032880,biological_process regulation of protein localization;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042470,cellular_component melanosome;GO:0045335,cellular_component phagocytic vesicle;GO:0045921,biological_process positive regulation of exocytosis;GO:0052405,biological_process negative regulation by host of symbiont molecular function;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	RAB9A, RAB9; Ras-related protein Rab-9A; K07899	RAB9A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9792]
ENSG00000131165	59.98	64.47	57.02	56.30	61.79	55.60	0.0720672348839425	5.47595136280311	0.342163161569465	0.717404514814585	16:89644430-89657845:-	CHMP1A	39;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005815,cellular_component microtubule organizing center;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0010008,cellular_component endosome membrane;GO:0010824,biological_process regulation of centrosome duplication;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016363,cellular_component nuclear matrix;GO:0016458,biological_process gene silencing;GO:0019904,molecular_function protein domain specific binding;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045014,biological_process negative regulation of transcription by glucose;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1904903,biological_process ESCRT III complex disassembly	NA	charged multivesicular body protein 1A [Source:HGNC Symbol%3BAcc:HGNC:8740]
ENSG00000181222	44.26	46.66	45.08	46.87	52.26	44.68	-0.069570059884545	6.31034039425036	0.34227561106583	0.717404514814585	17:7484365-7514616:+	POLR2A	32;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0001055,molecular_function RNA polymerase II activity;GO:0001172,biological_process transcription, RNA-templated;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0003968,molecular_function RNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005737,cellular_component cytoplasm;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033120,biological_process positive regulation of RNA splicing;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]; K03006	RNA polymerase II subunit A [Source:HGNC Symbol%3BAcc:HGNC:9187]
ENSG00000173812	1813.89	1598.30	1816.51	1905.64	1672.08	1965.07	-0.0721009176958104	9.43416707620747	0.342300941941854	0.717404514814585	17:41688884-41692668:+	EIF1	10;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0006950,biological_process response to stress;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0009048,biological_process dosage compensation by inactivation of X chromosome	EIF1, SUI1; translation initiation factor 1; K03113	eukaryotic translation initiation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:3249]
ENSG00000247077	14.23	15.81	15.40	16.48	16.36	16.10	-0.100278362815792	3.85903202157749	0.342352903704181	0.717404514814585	12:132710818-132722734:+	PGAM5	18;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007165,biological_process signal transduction;GO:0009400,molecular_function receptor signaling protein serine/threonine phosphatase activity;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0032403,molecular_function protein complex binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070266,biological_process necroptotic process	PGAM5; serine/threonine-protein phosphatase PGAM5 [EC:3.1.3.16]; K15637	PGAM family member 5%2C mitochondrial serine/threonine protein phosphatase [Source:HGNC Symbol%3BAcc:HGNC:28763]
ENSG00000167962	14.09	12.19	13.81	13.79	11.76	12.70	0.0846255060190639	5.06512461769659	0.342355893837726	0.717404514814585	16:1997653-2009823:-	ZNF598	1;GO:0003676,molecular_function nucleic acid binding	NA	zinc finger protein 598 [Source:HGNC Symbol%3BAcc:HGNC:28079]
ENSG00000132432	631.48	631.95	539.74	570.72	556.55	603.22	0.070015996159477	6.91079747274805	0.342414071029606	0.717404514814585	7:54752249-54759974:-	SEC61G	16;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006605,biological_process protein targeting;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0015450,molecular_function P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0045047,biological_process protein targeting to ER;GO:0071806,biological_process protein transmembrane transport	NA	Sec61 translocon gamma subunit [Source:HGNC Symbol%3BAcc:HGNC:18277]
ENSG00000158555	2.09	1.64	1.82	2.05	1.30	1.47	0.223545869544642	1.75757790516816	0.342433074218675	0.717404514814585	11:75434639-75525903:-	GDPD5	24;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006629,biological_process lipid metabolic process;GO:0007399,biological_process nervous system development;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008889,molecular_function glycerophosphodiester phosphodiesterase activity;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021895,biological_process cerebral cortex neuron differentiation;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031175,biological_process neuron projection development;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045787,biological_process positive regulation of cell cycle;GO:0047389,molecular_function glycerophosphocholine phosphodiesterase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048505,biological_process regulation of timing of cell differentiation;GO:0097038,cellular_component perinuclear endoplasmic reticulum	NA	glycerophosphodiester phosphodiesterase domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:28804]
ENSG00000077147	99.88	94.70	93.72	92.54	89.66	96.74	0.0595861635304823	7.38655367924679	0.342581008262628	0.717455021175449	10:96518108-96587452:-	TM9SF3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane 9 superfamily member 3 [Source:HGNC Symbol%3BAcc:HGNC:21529]
ENSG00000143653	76.83	78.78	76.00	79.76	79.14	84.58	-0.0613139853756746	6.67413120683376	0.342653671323228	0.717455021175449	1:246724046-246768137:+	SCCPDH	10;GO:0002576,biological_process platelet degranulation;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005811,cellular_component lipid particle;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030496,cellular_component midbody;GO:0031093,cellular_component platelet alpha granule lumen;GO:0055114,biological_process oxidation-reduction process	NA	saccharopine dehydrogenase (putative) [Source:HGNC Symbol%3BAcc:HGNC:24275]
ENSG00000113583	95.06	114.32	105.26	107.36	112.29	113.31	-0.0729022913280289	6.42528664309854	0.342661092897919	0.717455021175449	5:133955501-133968787:-	C5orf15	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 5 open reading frame 15 [Source:HGNC Symbol%3BAcc:HGNC:20656]
ENSG00000048392	12.74	11.89	14.07	12.27	11.67	12.69	0.0962153721947434	4.14199541752508	0.342749688715909	0.717455021175449	8:102204501-102239118:-	RRM2B	26;GO:0001822,biological_process kidney development;GO:0003014,biological_process renal system process;GO:0004748,molecular_function ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005971,cellular_component ribonucleoside-diphosphate reductase complex;GO:0006260,biological_process DNA replication;GO:0006264,biological_process mitochondrial DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0009200,biological_process deoxyribonucleoside triphosphate metabolic process;GO:0009263,biological_process deoxyribonucleotide biosynthetic process;GO:0014075,biological_process response to amine;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:1902254,biological_process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]; K10808	ribonucleotide reductase regulatory TP53 inducible subunit M2B [Source:HGNC Symbol%3BAcc:HGNC:17296]
ENSG00000116459	212.71	221.74	209.02	202.58	219.13	199.60	0.0617258062268452	7.34078056697228	0.34278453228534	0.717455021175449	1:111448863-111462773:+	ATP5F1	26;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005759,cellular_component mitochondrial matrix;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0021762,biological_process substantia nigra development;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0043209,cellular_component myelin sheath;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF0B, ATP5F1, ATP4; F-type H+-transporting ATPase subunit b; K02127	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit B1 [Source:HGNC Symbol%3BAcc:HGNC:840]
ENSG00000081377	6.01	6.15	5.64	6.33	5.89	7.18	-0.118153287284585	3.56375483594038	0.342803974107112	0.717455021175449	9:96490240-96619830:-	CDC14B	27;GO:0000922,cellular_component spindle pole;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006281,biological_process DNA repair;GO:0006470,biological_process protein dephosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007096,biological_process regulation of exit from mitosis;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0051256,biological_process mitotic spindle midzone assembly;GO:0060271,biological_process cilium morphogenesis;GO:0071850,biological_process mitotic cell cycle arrest;GO:0072686,cellular_component mitotic spindle;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]; K06639	cell division cycle 14B [Source:HGNC Symbol%3BAcc:HGNC:1719]
ENSG00000214309	1.77	2.16	1.66	1.88	2.95	2.03	-0.293521845171107	0.847386493959634	0.342949283685824	0.717579295630911	7:100126693-100128498:+	MBLAC1	2;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	metallo-beta-lactamase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:22180]
ENSG00000205702	1.73	1.97	1.85	1.30	2.10	1.36	0.229077248534379	1.48622918196677	0.342978970513026	0.717579295630911	22:42140202-42144577:-	CYP2D7	17;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006805,biological_process xenobiotic metabolic process;GO:0008395,molecular_function steroid hydroxylase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016712,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0019369,biological_process arachidonic acid metabolic process;GO:0020037,molecular_function heme binding;GO:0042738,biological_process exogenous drug catabolic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070330,molecular_function aromatase activity	CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]; K07414	cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) [Source:HGNC Symbol%3BAcc:HGNC:2624]
ENSG00000077150	15.75	14.79	16.33	16.00	13.93	15.03	0.0744393135533689	5.37605529665289	0.343093510905537	0.717697969475973	10:102394109-102402529:+	NFKB2	32;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002268,biological_process follicular dendritic cell differentiation;GO:0002467,biological_process germinal center formation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007568,biological_process aging;GO:0030198,biological_process extracellular matrix organization;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032496,biological_process response to lipopolysaccharide;GO:0033257,cellular_component Bcl3/NF-kappaB2 complex;GO:0034097,biological_process response to cytokine;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process;GO:0048536,biological_process spleen development;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; K04469	nuclear factor kappa B subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:7795]
ENSG00000177045	11.63	10.39	13.18	10.54	11.12	11.70	0.0948288318236553	4.67543488432931	0.343183456618588	0.717723881690523	19:45764784-45769226:-	SIX5	15;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0002088,biological_process lens development in camera-type eye;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007286,biological_process spermatid development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1902723,biological_process negative regulation of skeletal muscle satellite cell proliferation	NA	SIX homeobox 5 [Source:HGNC Symbol%3BAcc:HGNC:10891]
ENSG00000165097	14.33	15.29	14.58	14.22	18.22	14.92	-0.0891044621433013	5.24130596535303	0.343221538847575	0.717723881690523	6:18155328-18223853:+	KDM1B	24;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0032452,molecular_function histone demethylase activity;GO:0034648,molecular_function histone demethylase activity (H3-dimethyl-K4 specific);GO:0034649,molecular_function histone demethylase activity (H3-monomethyl-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0042393,molecular_function histone binding;GO:0043046,biological_process DNA methylation involved in gamete generation;GO:0044030,biological_process regulation of DNA methylation;GO:0046872,molecular_function metal ion binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	NA	lysine demethylase 1B [Source:HGNC Symbol%3BAcc:HGNC:21577]
ENSG00000123444	10.10	12.91	10.56	9.62	10.80	10.95	0.099168796671616	4.28215564662957	0.343310600120522	0.717735535514632	11:47572196-47579015:-	KBTBD4	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	NA	kelch repeat and BTB domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:23761]
ENSG00000175193	5.76	3.86	2.91	4.95	4.69	4.95	-0.200853676231411	2.44683039346492	0.343383785863265	0.717735535514632	3:183829270-183884933:-	PARL	18;GO:0004175,molecular_function endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006508,biological_process proteolysis;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0010821,biological_process regulation of mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030162,biological_process regulation of proteolysis;GO:0033619,biological_process membrane protein proteolysis;GO:1903214,biological_process regulation of protein targeting to mitochondrion;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	NA	presenilin associated rhomboid like [Source:HGNC Symbol%3BAcc:HGNC:18253]
ENSG00000184203	49.04	55.81	55.23	57.50	57.15	55.13	-0.0766503315619721	5.10880638474734	0.343400575640167	0.717735535514632	3:195514424-195543386:-	PPP1R2	12;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0004865,molecular_function protein serine/threonine phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0009966,biological_process regulation of signal transduction;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043666,biological_process regulation of phosphoprotein phosphatase activity	NA	protein phosphatase 1 regulatory inhibitor subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:9288]
ENSG00000108557	24.58	21.69	23.87	22.78	22.47	22.50	0.0635803284039679	7.10093221327179	0.343498257909408	0.717818834247388	17:17681472-17811453:+	RAI1	15;GO:0001501,biological_process skeletal system development;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0032922,biological_process circadian regulation of gene expression;GO:0035326,molecular_function enhancer binding;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process	NA	retinoic acid induced 1 [Source:HGNC Symbol%3BAcc:HGNC:9834]
ENSG00000182986	1.39	2.13	1.35	1.03	1.54	1.52	0.230552799664642	1.26120020379617	0.343638524606439	0.717991079942725	19:52863789-52897693:-	ZNF320	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 320 [Source:HGNC Symbol%3BAcc:HGNC:13842]
ENSG00000212657	0.87	1.17	1.04	1.26	1.22	1.27	-0.288064346981427	0.935865718174814	0.343758715987907	0.718121329780864	17:41307699-41309253:-	KRTAP16-1	4;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0031424,biological_process keratinization;GO:0045095,cellular_component keratin filament	NA	keratin associated protein 16-1 [Source:HGNC Symbol%3BAcc:HGNC:18916]
ENSG00000254505	5.01	6.22	4.28	4.53	4.85	4.25	0.180927617223044	2.10033750110526	0.344067733810748	0.718583382929049	14:24209582-24213869:-	CHMP4A	39;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006620,biological_process posttranslational protein targeting to membrane;GO:0006810,biological_process transport;GO:0006900,biological_process membrane budding;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008289,molecular_function lipid binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010324,biological_process membrane invagination;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0030117,cellular_component membrane coat;GO:0030496,cellular_component midbody;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0051117,molecular_function ATPase binding;GO:0051258,biological_process protein polymerization;GO:0051260,biological_process protein homooligomerization;GO:0070062,cellular_component extracellular exosome;GO:0097320,biological_process membrane tubulation;GO:1901215,biological_process negative regulation of neuron death;GO:1902902,biological_process negative regulation of autophagosome assembly	CHMP4, SNF7, VPS32; charged multivesicular body protein 4; K12194	charged multivesicular body protein 4A [Source:HGNC Symbol%3BAcc:HGNC:20274]
ENSG00000167118	45.27	43.93	46.78	49.09	48.06	47.52	-0.0749978250373422	4.68547340476443	0.34409567615647	0.718583382929049	9:128371318-128392016:+	URM1	10;GO:0002098,biological_process tRNA wobble uridine modification;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0016783,molecular_function sulfurtransferase activity;GO:0032447,biological_process protein urmylation;GO:0034227,biological_process tRNA thio-modification;GO:0070062,cellular_component extracellular exosome	URM1; ubiquitin related modifier 1; K12161	ubiquitin related modifier 1 [Source:HGNC Symbol%3BAcc:HGNC:28378]
ENSG00000173588	7.81	6.02	9.04	8.07	8.66	8.38	-0.112471711128482	4.16285746443581	0.344188302620697	0.718655912603988	12:94306448-94459988:-	CEP83	14;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0048278,biological_process vesicle docking;GO:0051660,biological_process establishment of centrosome localization;GO:0060271,biological_process cilium morphogenesis;GO:0071539,biological_process protein localization to centrosome;GO:0097539,cellular_component ciliary transition fiber;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 83 [Source:HGNC Symbol%3BAcc:HGNC:17966]
ENSG00000183963	9.31	9.85	8.48	10.24	10.08	9.08	-0.0806013964279662	5.17780103041348	0.344417924503501	0.71891001170838	22:31064104-31104757:+	SMTN	7;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006939,biological_process smooth muscle contraction;GO:0007517,biological_process muscle organ development;GO:0008307,molecular_function structural constituent of muscle;GO:0015629,cellular_component actin cytoskeleton	NA	smoothelin [Source:HGNC Symbol%3BAcc:HGNC:11126]
ENSG00000196639	9.04	8.57	9.17	9.07	7.99	8.09	0.106158082991765	3.6788472418179	0.344425830953818	0.71891001170838	3:11137092-11263557:+	HRH1	23;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004969,molecular_function histamine receptor activity;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007613,biological_process memory;GO:0008542,biological_process visual learning;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019229,biological_process regulation of vasoconstriction;GO:0032962,biological_process positive regulation of inositol trisphosphate biosynthetic process;GO:0043114,biological_process regulation of vascular permeability;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0048016,biological_process inositol phosphate-mediated signaling;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048245,biological_process eosinophil chemotaxis;GO:0050804,biological_process modulation of synaptic transmission;GO:0071420,biological_process cellular response to histamine	HRH1; histamine receptor H1; K04149	histamine receptor H1 [Source:HGNC Symbol%3BAcc:HGNC:5182]
ENSG00000106086	9.92	8.78	9.29	10.34	9.76	10.09	-0.0909542674605087	4.04947870249289	0.344706375830865	0.719374620576417	7:30027403-30130483:+	PLEKHA8	19;GO:0000139,cellular_component Golgi membrane;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017089,molecular_function glycolipid transporter activity;GO:0035621,biological_process ER to Golgi ceramide transport;GO:0046836,biological_process glycolipid transport;GO:0051861,molecular_function glycolipid binding;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0097001,molecular_function ceramide binding;GO:0120009,biological_process intermembrane lipid transfer;GO:0120013,molecular_function intermembrane lipid transfer activity	NA	pleckstrin homology domain containing A8 [Source:HGNC Symbol%3BAcc:HGNC:30037]
ENSG00000090621	95.98	95.84	91.06	104.64	92.86	100.26	-0.0625342701838408	7.66545779554453	0.344856327342082	0.719430722906981	1:39560815-39576790:-	PABPC4	14;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006401,biological_process RNA catabolic process;GO:0006412,biological_process translation;GO:0007596,biological_process blood coagulation;GO:0008143,molecular_function poly(A) binding;GO:0008266,molecular_function poly(U) RNA binding;GO:0010494,cellular_component cytoplasmic stress granule;GO:0030529,cellular_component intracellular ribonucleoprotein complex	PABPC; polyadenylate-binding protein; K13126	poly(A) binding protein cytoplasmic 4 [Source:HGNC Symbol%3BAcc:HGNC:8557]
ENSG00000005075	83.37	90.69	90.34	95.28	97.11	87.42	-0.071249253736124	5.53649934097922	0.344884363299177	0.719430722906981	7:102473117-102478907:-	POLR2J	22;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001055,molecular_function RNA polymerase II activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0030275,molecular_function LRR domain binding;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11; K03008	RNA polymerase II subunit J [Source:HGNC Symbol%3BAcc:HGNC:9197]
ENSG00000117475	22.92	24.77	26.24	22.99	24.92	22.60	0.079771407200458	4.92258028853775	0.345000918654359	0.719430722906981	1:169367969-169396540:+	BLZF1	18;GO:0000139,cellular_component Golgi membrane;GO:0001558,biological_process regulation of cell growth;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0007030,biological_process Golgi organization;GO:0008283,biological_process cell proliferation;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0019899,molecular_function enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043001,biological_process Golgi to plasma membrane protein transport	NA	basic leucine zipper nuclear factor 1 [Source:HGNC Symbol%3BAcc:HGNC:1065]
ENSG00000136448	56.36	60.49	53.39	62.02	61.68	56.16	-0.0692955273958299	6.46852268689212	0.345077472851386	0.719430722906981	17:45051609-45109016:+	NMT1	16;GO:0001701,biological_process in utero embryonic development;GO:0004379,molecular_function glycylpeptide N-tetradecanoyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006499,biological_process N-terminal protein myristoylation;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018008,biological_process N-terminal peptidyl-glycine N-myristoylation;GO:0019107,molecular_function myristoyltransferase activity;GO:0019898,cellular_component extrinsic component of membrane;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0042180,biological_process cellular ketone metabolic process;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	NA	N-myristoyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:7857]
ENSG00000140750	15.45	17.37	16.12	14.75	16.53	15.58	0.0705408633839106	5.46378882361146	0.345084813505875	0.719430722906981	16:24919384-25015666:-	ARHGAP17	13;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030054,cellular_component cell junction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 17 [Source:HGNC Symbol%3BAcc:HGNC:18239]
ENSG00000105426	12.82	11.30	12.81	12.01	11.56	12.06	0.0670740862471531	6.15239807953922	0.345145946321352	0.719430722906981	19:5158494-5340803:-	PTPRS	43;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007155,biological_process cell adhesion;GO:0008201,molecular_function heparin binding;GO:0010977,biological_process negative regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0021510,biological_process spinal cord development;GO:0021549,biological_process cerebellum development;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0022038,biological_process corpus callosum development;GO:0030054,cellular_component cell junction;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0030424,cellular_component axon;GO:0030517,biological_process negative regulation of axon extension;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032687,biological_process negative regulation of interferon-alpha production;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0034164,biological_process negative regulation of toll-like receptor 9 signaling pathway;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035374,molecular_function chondroitin sulfate binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043204,cellular_component perikaryon;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048671,biological_process negative regulation of collateral sprouting;GO:0048681,biological_process negative regulation of axon regeneration;GO:0061000,biological_process negative regulation of dendritic spine development;GO:0070062,cellular_component extracellular exosome;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:0099061,cellular_component integral component of postsynaptic density membrane	NA	protein tyrosine phosphatase%2C receptor type S [Source:HGNC Symbol%3BAcc:HGNC:9681]
ENSG00000012061	51.43	46.25	52.12	49.25	46.28	48.83	0.0687424182029646	5.75018923762537	0.345160049188522	0.719430722906981	19:45407332-45478828:-	ERCC1	63;GO:0000014,molecular_function single-stranded DNA endodeoxyribonuclease activity;GO:0000109,cellular_component nucleotide-excision repair complex;GO:0000110,cellular_component nucleotide-excision repair factor 1 complex;GO:0000710,biological_process meiotic mismatch repair;GO:0000720,biological_process pyrimidine dimer repair by nucleotide-excision repair;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0001302,biological_process replicative cell aging;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006312,biological_process mitotic recombination;GO:0006949,biological_process syncytium formation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007281,biological_process germ cell development;GO:0007283,biological_process spermatogenesis;GO:0007584,biological_process response to nutrient;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0008584,biological_process male gonad development;GO:0009650,biological_process UV protection;GO:0009744,biological_process response to sucrose;GO:0010165,biological_process response to X-ray;GO:0010259,biological_process multicellular organism aging;GO:0016787,molecular_function hydrolase activity;GO:0019904,molecular_function protein domain specific binding;GO:0032205,biological_process negative regulation of telomere maintenance;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0035166,biological_process post-embryonic hemopoiesis;GO:0035264,biological_process multicellular organism growth;GO:0036297,biological_process interstrand cross-link repair;GO:0045190,biological_process isotype switching;GO:0048468,biological_process cell development;GO:0048477,biological_process oogenesis;GO:0048568,biological_process embryonic organ development;GO:0051276,biological_process chromosome organization;GO:0061819,biological_process telomeric DNA-containing double minutes formation;GO:0070522,cellular_component ERCC4-ERCC1 complex;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070914,biological_process UV-damage excision repair;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090656,biological_process t-circle formation;GO:1904431,biological_process positive regulation of t-circle formation;GO:1905765,biological_process negative regulation of protection from non-homologous end joining at telomere;GO:1990599,molecular_function 3' overhang single-stranded DNA endodeoxyribonuclease activity	ERCC1; DNA excision repair protein ERCC-1; K10849	ERCC excision repair 1%2C endonuclease non-catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:3433]
ENSG00000186364	2.87	3.11	2.47	1.90	2.62	2.72	0.221376454574791	1.43932947651959	0.345196921423828	0.719430722906981	1:145845628-145848953:+	NUDT17	2;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	nudix hydrolase 17 [Source:HGNC Symbol%3BAcc:HGNC:26618]
ENSG00000159658	34.38	41.63	35.16	31.74	38.78	34.95	0.0837578606673983	5.80341204011528	0.345300656454037	0.719526111895914	1:46675158-46719064:-	EFCAB14	2;GO:0005509,molecular_function calcium ion binding;GO:0046872,molecular_function metal ion binding	NA	EF-hand calcium binding domain 14 [Source:HGNC Symbol%3BAcc:HGNC:29051]
ENSG00000184922	19.82	16.81	20.66	22.62	17.44	21.56	-0.0909906904963165	6.23344497953603	0.345714538353977	0.72026763420408	17:45221443-45247320:+	FMNL1	27;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006929,biological_process substrate-dependent cell migration;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0009987,biological_process cellular process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032059,cellular_component bleb;GO:0032794,molecular_function GTPase activating protein binding;GO:0042995,cellular_component cell projection;GO:0045335,cellular_component phagocytic vesicle;GO:0048365,molecular_function Rac GTPase binding;GO:0051014,biological_process actin filament severing;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	NA	formin like 1 [Source:HGNC Symbol%3BAcc:HGNC:1212]
ENSG00000144040	4.34	4.36	4.24	4.11	5.22	5.30	-0.167829403870006	2.35129184355763	0.34589713408504	0.720527122906126	2:72942035-73075619:-	SFXN5	13;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0015137,molecular_function citrate transmembrane transporter activity;GO:0015746,biological_process citrate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0034220,biological_process ion transmembrane transport;GO:0055072,biological_process iron ion homeostasis;GO:0055085,biological_process transmembrane transport	NA	sideroflexin 5 [Source:HGNC Symbol%3BAcc:HGNC:16073]
ENSG00000138768	58.65	60.86	59.68	55.99	60.62	56.78	0.0589296756287485	7.42430895131147	0.346089271666145	0.720806397515413	4:75724592-75814286:+	USO1	26;GO:0000139,cellular_component Golgi membrane;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0008565,molecular_function protein transporter activity;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0045056,biological_process transcytosis;GO:0045296,molecular_function cadherin binding;GO:0048208,biological_process COPII vesicle coating;GO:0048211,biological_process Golgi vesicle docking;GO:0048280,biological_process vesicle fusion with Golgi apparatus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061025,biological_process membrane fusion	NA	USO1 vesicle transport factor [Source:HGNC Symbol%3BAcc:HGNC:30904]
ENSG00000103852	8.25	10.59	8.86	8.65	7.90	9.18	0.105245518014635	3.90298179520115	0.346268157636867	0.721057983685024	15:99136322-99251223:-	TTC23	1;GO:0005515,molecular_function protein binding	NA	tetratricopeptide repeat domain 23 [Source:HGNC Symbol%3BAcc:HGNC:25730]
ENSG00000162733	0.31	0.38	0.30	0.47	0.44	0.36	-0.357620395883763	0.236622833489346	0.346392805904494	0.721135971975805	1:162631372-162787400:+	DDR2	41;GO:0000166,molecular_function nucleotide binding;GO:0001503,biological_process ossification;GO:0003416,biological_process endochondral bone growth;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010715,biological_process regulation of extracellular matrix disassembly;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0030500,biological_process regulation of bone mineralization;GO:0031214,biological_process biomineral tissue development;GO:0035988,biological_process chondrocyte proliferation;GO:0038062,molecular_function protein tyrosine kinase collagen receptor activity;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046777,biological_process protein autophosphorylation;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0070062,cellular_component extracellular exosome;GO:0090091,biological_process positive regulation of extracellular matrix disassembly	NA	discoidin domain receptor tyrosine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:2731]
ENSG00000172661	13.81	13.68	13.37	13.15	13.49	12.82	0.0617065135077675	5.75618857052887	0.346421799797931	0.721135971975805	10:45727199-45792961:+	WASHC2C	26;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005730,cellular_component nucleolus;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030904,cellular_component retromer complex;GO:0031901,cellular_component early endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0071203,cellular_component WASH complex;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:1900024,biological_process regulation of substrate adhesion-dependent cell spreading;GO:1905394,molecular_function retromer complex binding;GO:1990126,biological_process retrograde transport, endosome to plasma membrane;GO:2000813,biological_process negative regulation of barbed-end actin filament capping	NA	WASH complex subunit 2C [Source:HGNC Symbol%3BAcc:HGNC:23414]
ENSG00000167680	4.22	4.94	5.18	5.00	5.01	5.54	-0.111130779734863	3.84065092217783	0.346620025591185	0.721427628716194	19:4542592-4559808:-	SEMA6B	8;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030215,molecular_function semaphorin receptor binding	SEMA6; semaphorin 6; K06842	semaphorin 6B [Source:HGNC Symbol%3BAcc:HGNC:10739]
ENSG00000079156	5.12	4.90	5.51	5.80	4.72	6.43	-0.113002209416445	4.04973062094408	0.346910467173651	0.721669115293734	2:178194480-178402891:+	OSBPL6	17;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006699,biological_process bile acid biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0015248,molecular_function sterol transporter activity;GO:0015918,biological_process sterol transport;GO:0016020,cellular_component membrane;GO:0031965,cellular_component nuclear membrane;GO:0097038,cellular_component perinuclear endoplasmic reticulum	NA	oxysterol binding protein like 6 [Source:HGNC Symbol%3BAcc:HGNC:16388]
ENSG00000112706	0.40	0.29	0.31	0.48	0.37	0.45	-0.360641571872552	0.235824524698616	0.347013557657382	0.721669115293734	6:75921114-76072678:-	IMPG1	4;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0007601,biological_process visual perception	NA	interphotoreceptor matrix proteoglycan 1 [Source:HGNC Symbol%3BAcc:HGNC:6055]
ENSG00000122642	153.71	156.61	151.16	146.31	152.25	149.33	0.0546484889200492	8.15382781160129	0.347046651696475	0.721669115293734	7:32957403-33006931:+	FKBP9	10;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005509,molecular_function calcium ion binding;GO:0005528,molecular_function FK506 binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006457,biological_process protein folding;GO:0016853,molecular_function isomerase activity;GO:0046872,molecular_function metal ion binding;GO:0061077,biological_process chaperone-mediated protein folding	NA	FK506 binding protein 9 [Source:HGNC Symbol%3BAcc:HGNC:3725]
ENSG00000177483	0.69	0.55	0.61	0.66	0.60	0.96	-0.250536183676351	1.21159306665758	0.347070623735143	0.721669115293734	2:237798388-237842808:+	RBM44	5;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0042803,molecular_function protein homodimerization activity;GO:0045171,cellular_component intercellular bridge	NA	RNA binding motif protein 44 [Source:HGNC Symbol%3BAcc:HGNC:24756]
ENSG00000254858	4.57	7.27	6.07	7.63	6.50	6.49	-0.212587035128496	2.03410674695503	0.347096490105874	0.721669115293734	19:18193181-18196948:+	MPV17L2	7;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0061668,biological_process mitochondrial ribosome assembly;GO:0070131,biological_process positive regulation of mitochondrial translation	MPV17; protein Mpv17; K13348	MPV17 mitochondrial inner membrane protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:28177]
ENSG00000175931	16.60	17.64	17.59	18.14	15.66	15.97	0.0692679595159982	6.04109316873584	0.347142212867	0.721669115293734	17:76389450-76453206:-	UBE2O	19;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006513,biological_process protein monoubiquitination;GO:0006810,biological_process transport;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070534,biological_process protein K63-linked ubiquitination	UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]; K10581	ubiquitin conjugating enzyme E2 O [Source:HGNC Symbol%3BAcc:HGNC:29554]
ENSG00000164548	108.88	104.76	112.19	110.49	116.67	115.55	-0.0599740716093837	6.69102955837194	0.347143018401586	0.721669115293734	7:23504779-23532041:-	TRA2A	8;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0043231,cellular_component intracellular membrane-bounded organelle	TRA2; transformer-2 protein; K12897	transformer 2 alpha homolog [Source:HGNC Symbol%3BAcc:HGNC:16645]
ENSG00000022567	2.08	1.32	1.84	1.84	2.66	1.65	-0.201168791173869	2.40267349277446	0.347279418543845	0.721709651361152	8:141207165-141308305:-	SLC45A4	5;GO:0006810,biological_process transport;GO:0008506,molecular_function sucrose:proton symporter activity;GO:0015770,biological_process sucrose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 45 member 4 [Source:HGNC Symbol%3BAcc:HGNC:29196]
ENSG00000152782	6.71	7.34	5.90	6.53	6.70	5.09	0.129600570571112	3.55092669072527	0.347328086129307	0.721709651361152	10:89579496-89645572:-	PANK1	14;GO:0000166,molecular_function nucleotide binding;GO:0004594,molecular_function pantothenate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009108,biological_process coenzyme biosynthetic process;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030118,cellular_component clathrin coat;GO:0055037,cellular_component recycling endosome;GO:0071944,cellular_component cell periphery	coaW; type II pantothenate kinase [EC:2.7.1.33]; K09680	pantothenate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:8598]
ENSG00000138400	1.30	1.70	0.77	1.42	1.67	1.42	-0.279964088064385	1.25289680110375	0.347398894350965	0.721709651361152	2:206737762-206765547:-	MDH1B	12;GO:0003824,molecular_function catalytic activity;GO:0005737,cellular_component cytoplasm;GO:0005975,biological_process carbohydrate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006108,biological_process malate metabolic process;GO:0006734,biological_process NADH metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016615,molecular_function malate dehydrogenase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0030060,molecular_function L-malate dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process	NA	malate dehydrogenase 1B [Source:HGNC Symbol%3BAcc:HGNC:17836]
ENSG00000058063	21.08	20.98	20.25	21.37	19.53	19.20	0.063730096802591	6.23579388019618	0.347441165029222	0.721709651361152	3:182793499-182921635:+	ATP11B	27;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005637,cellular_component nuclear inner membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006869,biological_process lipid transport;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0015914,biological_process phospholipid transport;GO:0015917,biological_process aminophospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0034220,biological_process ion transmembrane transport;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane	NA	ATPase phospholipid transporting 11B (putative) [Source:HGNC Symbol%3BAcc:HGNC:13553]
ENSG00000282246	1.44	2.09	2.15	1.96	1.55	0.92	0.360237756636711	0.370586268912837	0.347453224565717	0.721709651361152	10:13610046-13655929:+	AL157392.5	8;GO:0000350,biological_process generation of catalytic spliceosome for second transesterification step;GO:0000386,molecular_function second spliceosomal transesterification activity;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0008380,biological_process RNA splicing;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071021,cellular_component U2-type post-spliceosomal complex;GO:0071048,biological_process nuclear retention of unspliced pre-mRNA at the site of transcription	PRPF18, PRP18; pre-mRNA-splicing factor 18; K12817	NA
ENSG00000138111	1.56	2.10	1.98	1.79	1.35	1.76	0.198876430612744	1.5870003019775	0.347555040805506	0.721800354947089	10:102461394-102477045:+	MFSD13A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	major facilitator superfamily domain containing 13A [Source:HGNC Symbol%3BAcc:HGNC:26196]
ENSG00000196642	66.30	70.63	71.73	67.19	67.73	67.15	0.0576779601961287	7.66216954787143	0.347676745494039	0.721932325496405	9:136807942-136841187:+	RABL6	8;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007264,biological_process small GTPase mediated signal transduction	NA	RAB%2C member RAS oncogene family like 6 [Source:HGNC Symbol%3BAcc:HGNC:24703]
ENSG00000166913	174.05	186.93	166.96	178.11	188.53	188.91	-0.0631098625972997	7.25026728167191	0.3477485642259	0.721933692080611	20:44885675-44908532:+	YWHAB	35;GO:0000165,biological_process MAPK cascade;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006605,biological_process protein targeting;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0017053,cellular_component transcriptional repressor complex;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0032403,molecular_function protein complex binding;GO:0035308,biological_process negative regulation of protein dephosphorylation;GO:0035329,biological_process hippo signaling;GO:0042470,cellular_component melanosome;GO:0042826,molecular_function histone deacetylase binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0043488,biological_process regulation of mRNA stability;GO:0045296,molecular_function cadherin binding;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050815,molecular_function phosphoserine binding;GO:0051219,molecular_function phosphoprotein binding;GO:0051220,biological_process cytoplasmic sequestering of protein;GO:0051291,biological_process protein heterooligomerization;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	NA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol%3BAcc:HGNC:12849]
ENSG00000133612	17.31	18.07	18.63	17.15	16.31	18.56	0.0649365760132782	6.09590970225893	0.347793722600665	0.721933692080611	7:151085830-151144436:+	AGAP3	9;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11; K12491	ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 3 [Source:HGNC Symbol%3BAcc:HGNC:16923]
ENSG00000148835	1.97	1.83	1.87	1.44	2.05	1.55	0.187728634765412	2.14884710896281	0.34791664099368	0.722068093070483	10:103367966-103389065:+	TAF5	22;GO:0000790,cellular_component nuclear chromatin;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0015629,cellular_component actin cytoskeleton;GO:0016032,biological_process viral process;GO:0016573,biological_process histone acetylation;GO:0033276,cellular_component transcription factor TFTC complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0046983,molecular_function protein dimerization activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF5; transcription initiation factor TFIID subunit 5; K03130	TATA-box binding protein associated factor 5 [Source:HGNC Symbol%3BAcc:HGNC:11539]
ENSG00000114739	2.76	3.11	3.79	2.97	3.21	2.43	0.181001089772602	2.26806057184003	0.348030602965375	0.722183864026948	3:38453850-38493142:+	ACVR2B	59;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001822,biological_process kidney development;GO:0001946,biological_process lymphangiogenesis;GO:0001974,biological_process blood vessel remodeling;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007368,biological_process determination of left/right symmetry;GO:0007389,biological_process pattern specification process;GO:0007498,biological_process mesoderm development;GO:0007507,biological_process heart development;GO:0009749,biological_process response to glucose;GO:0009791,biological_process post-embryonic development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016362,molecular_function activin receptor activity, type II;GO:0016740,molecular_function transferase activity;GO:0019838,molecular_function growth factor binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030073,biological_process insulin secretion;GO:0030324,biological_process lung development;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0031016,biological_process pancreas development;GO:0032147,biological_process activation of protein kinase activity;GO:0032924,biological_process activin receptor signaling pathway;GO:0032927,biological_process positive regulation of activin receptor signaling pathway;GO:0035265,biological_process organ growth;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043234,cellular_component protein complex;GO:0043235,cellular_component receptor complex;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0046872,molecular_function metal ion binding;GO:0048185,molecular_function activin binding;GO:0048617,biological_process embryonic foregut morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0060021,biological_process palate development;GO:0060836,biological_process lymphatic endothelial cell differentiation;GO:0060840,biological_process artery development;GO:0060841,biological_process venous blood vessel development;GO:0061298,biological_process retina vasculature development in camera-type eye	ACVR2B; activin receptor type-2B [EC:2.7.11.30]; K13596	activin A receptor type 2B [Source:HGNC Symbol%3BAcc:HGNC:174]
ENSG00000083099	34.13	36.60	30.27	37.34	37.63	34.35	-0.108105608132193	3.78343470911941	0.348317307829187	0.72240802494612	6:89568143-89638753:-	LYRM2	2;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion	NA	LYR motif containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25229]
ENSG00000166821	12.90	13.69	14.89	12.50	12.36	13.77	0.112886170143157	3.36639262835046	0.348338463208535	0.72240802494612	15:89677763-89690783:-	PEX11A	15;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0007031,biological_process peroxisome organization;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016557,biological_process peroxisome membrane biogenesis;GO:0016559,biological_process peroxisome fission;GO:0019216,biological_process regulation of lipid metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0044375,biological_process regulation of peroxisome size;GO:0050873,biological_process brown fat cell differentiation	PEX11A; peroxin-11A; K13351	peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol%3BAcc:HGNC:8852]
ENSG00000029725	21.64	19.76	19.60	20.37	19.66	18.78	0.066574351810283	5.89493018222839	0.348343284544187	0.72240802494612	17:5282264-5385812:+	RABEP1	22;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0008083,molecular_function growth factor activity;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0019904,molecular_function protein domain specific binding;GO:0030139,cellular_component endocytic vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:0061025,biological_process membrane fusion	RABEP1; Rab GTPase-binding effector protein 1; K12480	rabaptin%2C RAB GTPase binding effector protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17677]
ENSG00000168890	17.77	15.79	19.08	14.72	17.94	16.78	0.109261029812622	3.99503217027362	0.348371420069884	0.72240802494612	2:85598547-85603196:-	TMEM150A	9;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0009056,biological_process catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	transmembrane protein 150A [Source:HGNC Symbol%3BAcc:HGNC:24677]
ENSG00000097021	54.27	59.21	54.30	55.85	52.48	53.46	0.0617727333740494	6.33184374152259	0.348489308289937	0.722531782829963	1:6264268-6394391:-	ACOT7	20;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006637,biological_process acyl-CoA metabolic process;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016290,molecular_function palmitoyl-CoA hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0036042,molecular_function long-chain fatty acyl-CoA binding;GO:0036114,biological_process medium-chain fatty-acyl-CoA catabolic process;GO:0036116,biological_process long-chain fatty-acyl-CoA catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0047617,molecular_function acyl-CoA hydrolase activity;GO:0051792,biological_process medium-chain fatty acid biosynthetic process;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0102991,molecular_function myristoyl-CoA hydrolase activity;GO:1900535,biological_process palmitic acid biosynthetic process	ACOT7; acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]; K17360	acyl-CoA thioesterase 7 [Source:HGNC Symbol%3BAcc:HGNC:24157]
ENSG00000178053	25.23	27.47	27.12	24.91	26.66	24.65	0.0758250017727156	4.79305961014102	0.348620259463071	0.722682578609735	3:158571162-158607252:+	MLF1	11;GO:0002318,biological_process myeloid progenitor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007275,biological_process multicellular organism development;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation	MLF1; myeloid leukemia factor 1; K15622	myeloid leukemia factor 1 [Source:HGNC Symbol%3BAcc:HGNC:7125]
ENSG00000184349	28.09	26.21	28.52	24.88	27.19	26.64	0.0893974211631012	4.22702785656867	0.34870489243816	0.722686934286723	5:107376888-107670895:-	EFNA5	38;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005168,molecular_function neurotrophin TRKA receptor binding;GO:0005169,molecular_function neurotrophin TRKB receptor binding;GO:0005170,molecular_function neurotrophin TRKC receptor binding;GO:0005604,cellular_component basement membrane;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0005912,cellular_component adherens junction;GO:0007171,biological_process activation of transmembrane receptor protein tyrosine kinase activity;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022407,biological_process regulation of cell-cell adhesion;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030154,biological_process cell differentiation;GO:0030297,molecular_function transmembrane receptor protein tyrosine kinase activator activity;GO:0031225,cellular_component anchored component of membrane;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0043087,biological_process regulation of GTPase activity;GO:0045499,molecular_function chemorepellent activity;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048668,biological_process collateral sprouting;GO:0048672,biological_process positive regulation of collateral sprouting;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050919,biological_process negative chemotaxis;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0051965,biological_process positive regulation of synapse assembly;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0071944,cellular_component cell periphery;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:1904322,biological_process cellular response to forskolin	EFNA; ephrin-A; K05462	ephrin A5 [Source:HGNC Symbol%3BAcc:HGNC:3225]
ENSG00000102241	35.11	39.91	32.95	35.77	40.35	38.43	-0.0764351256259583	6.39446272993863	0.348779556121921	0.722686934286723	X:136497078-136512346:+	HTATSF1	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005684,cellular_component U2-type spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0019079,biological_process viral genome replication;GO:0032784,biological_process regulation of DNA-templated transcription, elongation	NA	HIV-1 Tat specific factor 1 [Source:HGNC Symbol%3BAcc:HGNC:5276]
ENSG00000181264	11.73	14.08	11.12	11.59	10.23	12.11	0.119927011275617	3.25808303181227	0.348797021132019	0.722686934286723	11:120325128-120333682:+	TMEM136	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 136 [Source:HGNC Symbol%3BAcc:HGNC:28280]
ENSG00000086289	87.49	101.62	89.72	83.56	100.86	80.43	0.0839998857876989	6.10359941651669	0.34890319404179	0.72278627297075	7:37683842-37951941:+	EPDR1	6;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0007160,biological_process cell-matrix adhesion;GO:0070062,cellular_component extracellular exosome	NA	ependymin related 1 [Source:HGNC Symbol%3BAcc:HGNC:17572]
ENSG00000186854	8.07	8.85	9.52	7.91	8.32	8.54	0.103193526260496	3.71630547702409	0.349081289139804	0.723034547320604	2:84821649-84907008:-	TRABD2A	18;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016787,molecular_function hydrolase activity;GO:0017147,molecular_function Wnt-protein binding;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0031301,cellular_component integral component of organelle membrane;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0046872,molecular_function metal ion binding;GO:0060322,biological_process head development;GO:1904808,biological_process positive regulation of protein oxidation	NA	TraB domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:27013]
ENSG00000162735	26.62	25.89	24.35	26.29	28.34	27.18	-0.0786664407042819	4.63643241568486	0.349266723272388	0.723086716293324	1:160276811-160286348:-	PEX19	22;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0006625,biological_process protein targeting to peroxisome;GO:0007031,biological_process peroxisome organization;GO:0016020,cellular_component membrane;GO:0016559,biological_process peroxisome fission;GO:0031526,cellular_component brush border membrane;GO:0036105,molecular_function peroxisome membrane class-1 targeting sequence binding;GO:0043234,cellular_component protein complex;GO:0045046,biological_process protein import into peroxisome membrane;GO:0047485,molecular_function protein N-terminus binding;GO:0050821,biological_process protein stabilization;GO:0051117,molecular_function ATPase binding;GO:0055085,biological_process transmembrane transport;GO:0061077,biological_process chaperone-mediated protein folding;GO:0072321,biological_process chaperone-mediated protein transport;GO:0072663,biological_process establishment of protein localization to peroxisome;GO:1900131,biological_process negative regulation of lipid binding	PEX19; peroxin-19; K13337	peroxisomal biogenesis factor 19 [Source:HGNC Symbol%3BAcc:HGNC:9713]
ENSG00000187608	21.26	19.11	16.06	15.43	17.47	18.89	0.134118384886489	3.18301402792764	0.349291888455789	0.723086716293324	1:1001137-1014541:+	ISG15	22;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016032,biological_process viral process;GO:0019941,biological_process modification-dependent protein catabolic process;GO:0019985,biological_process translesion synthesis;GO:0030501,biological_process positive regulation of bone mineralization;GO:0031386,molecular_function protein tag;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032020,biological_process ISG15-protein conjugation;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032649,biological_process regulation of interferon-gamma production;GO:0034340,biological_process response to type I interferon;GO:0042742,biological_process defense response to bacterium;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway	ISG15; ubiquitin cross-reactive protein; K12159	ISG15 ubiquitin-like modifier [Source:HGNC Symbol%3BAcc:HGNC:4053]
ENSG00000135046	758.68	771.75	755.46	789.69	807.71	792.28	-0.052338942292049	9.7060645866142	0.349299272078371	0.723086716293324	9:73151756-73170393:+	ANXA1	114;GO:0000733,biological_process DNA strand renaturation;GO:0001533,cellular_component cornified envelope;GO:0001780,biological_process neutrophil homeostasis;GO:0001891,cellular_component phagocytic cup;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002548,biological_process monocyte chemotaxis;GO:0002685,biological_process regulation of leukocyte migration;GO:0003697,molecular_function single-stranded DNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004386,molecular_function helicase activity;GO:0004859,molecular_function phospholipase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005198,molecular_function structural molecule activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0005929,cellular_component cilium;GO:0006909,biological_process phagocytosis;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007187,biological_process G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0008360,biological_process regulation of cell shape;GO:0009725,biological_process response to hormone;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0010165,biological_process response to X-ray;GO:0014070,biological_process response to organic cyclic compound;GO:0014839,biological_process myoblast migration involved in skeletal muscle regeneration;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0018149,biological_process peptide cross-linking;GO:0019834,molecular_function phospholipase A2 inhibitor activity;GO:0019898,cellular_component extrinsic component of membrane;GO:0030073,biological_process insulin secretion;GO:0030216,biological_process keratinocyte differentiation;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030674,molecular_function protein binding, bridging;GO:0030850,biological_process prostate gland development;GO:0031018,biological_process endocrine pancreas development;GO:0031232,cellular_component extrinsic component of external side of plasma membrane;GO:0031313,cellular_component extrinsic component of endosome membrane;GO:0031340,biological_process positive regulation of vesicle fusion;GO:0031394,biological_process positive regulation of prostaglandin biosynthetic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031514,cellular_component motile cilium;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031901,cellular_component early endosome membrane;GO:0031960,biological_process response to corticosteroid;GO:0031966,cellular_component mitochondrial membrane;GO:0031982,cellular_component vesicle;GO:0032355,biological_process response to estradiol;GO:0032508,biological_process DNA duplex unwinding;GO:0032652,biological_process regulation of interleukin-1 production;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0033031,biological_process positive regulation of neutrophil apoptotic process;GO:0033676,molecular_function double-stranded DNA-dependent ATPase activity;GO:0036292,biological_process DNA rewinding;GO:0036310,molecular_function annealing helicase activity;GO:0042063,biological_process gliogenesis;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042127,biological_process regulation of cell proliferation;GO:0042383,cellular_component sarcolemma;GO:0042493,biological_process response to drug;GO:0042629,cellular_component mast cell granule;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0044849,biological_process estrous cycle;GO:0045087,biological_process innate immune response;GO:0045627,biological_process positive regulation of T-helper 1 cell differentiation;GO:0045629,biological_process negative regulation of T-helper 2 cell differentiation;GO:0045920,biological_process negative regulation of exocytosis;GO:0046632,biological_process alpha-beta T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0046883,biological_process regulation of hormone secretion;GO:0048306,molecular_function calcium-dependent protein binding;GO:0050482,biological_process arachidonic acid secretion;GO:0050709,biological_process negative regulation of protein secretion;GO:0050727,biological_process regulation of inflammatory response;GO:0051384,biological_process response to glucocorticoid;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070365,biological_process hepatocyte differentiation;GO:0070459,biological_process prolactin secretion;GO:0070555,biological_process response to interleukin-1;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0071621,biological_process granulocyte chemotaxis;GO:0090303,biological_process positive regulation of wound healing;GO:0097350,biological_process neutrophil clearance;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1900138,biological_process negative regulation of phospholipase A2 activity;GO:2000483,biological_process negative regulation of interleukin-8 secretion	NA	annexin A1 [Source:HGNC Symbol%3BAcc:HGNC:533]
ENSG00000065054	23.65	22.85	27.64	28.74	22.20	29.31	-0.101055616981128	5.08009342999441	0.349496820524712	0.723086716293324	16:2025355-2039026:+	SLC9A3R2	15;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006461,biological_process protein complex assembly;GO:0008013,molecular_function beta-catenin binding;GO:0008022,molecular_function protein C-terminus binding;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019902,molecular_function phosphatase binding;GO:0032947,molecular_function protein complex scaffold;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	SLC9A3R2, NHERF2; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; K13358	SLC9A3 regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:11076]
ENSG00000110367	56.63	64.80	60.07	55.63	60.29	58.69	0.0651085260738098	6.44220559861097	0.349535075651583	0.723086716293324	11:118747765-118791149:-	DDX6	32;GO:0000166,molecular_function nucleotide binding;GO:0000792,cellular_component heterochromatin;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001520,cellular_component outer dense fiber;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0007283,biological_process spermatogenesis;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016442,cellular_component RISC complex;GO:0016787,molecular_function hydrolase activity;GO:0019074,biological_process viral RNA genome packaging;GO:0019827,biological_process stem cell population maintenance;GO:0019904,molecular_function protein domain specific binding;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0043186,cellular_component P granule;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045296,molecular_function cadherin binding;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0097227,cellular_component sperm annulus	DDX6, RCK, DHH1; ATP-dependent RNA helicase DDX6/DHH1 [EC:3.6.4.13]; K12614	DEAD-box helicase 6 [Source:HGNC Symbol%3BAcc:HGNC:2747]
ENSG00000239779	68.14	60.90	69.97	63.28	64.46	64.31	0.0665444942469991	6.10611512087913	0.349563718271257	0.723086716293324	2:74458328-74460891:+	WBP1	6;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050699,molecular_function WW domain binding	NA	WW domain binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:12737]
ENSG00000116871	37.17	39.85	39.09	37.93	36.37	37.88	0.0602025368022612	6.58753077836112	0.34959229162836	0.723086716293324	1:36155578-36180849:+	MAP7D1	7;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005198,molecular_function structural molecule activity;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0015630,cellular_component microtubule cytoskeleton	NA	MAP7 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25514]
ENSG00000137842	9.01	7.33	9.39	10.05	9.16	8.75	-0.0978220190138637	4.12859231668124	0.349593342709151	0.723086716293324	15:43123278-43185146:+	TMEM62	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity	NA	transmembrane protein 62 [Source:HGNC Symbol%3BAcc:HGNC:26269]
ENSG00000160741	18.84	18.77	20.23	18.94	16.81	19.66	0.0738761644097057	5.31769733368087	0.34963074769939	0.723086716293324	1:153947668-153958625:-	CRTC2	17;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006094,biological_process gluconeogenesis;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008140,molecular_function cAMP response element binding protein binding;GO:0016032,biological_process viral process;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0042593,biological_process glucose homeostasis;GO:0043970,biological_process histone H3-K9 acetylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051289,biological_process protein homotetramerization;GO:0070062,cellular_component extracellular exosome;GO:1901998,biological_process toxin transport	CRTC2, TORC2; CREB-regulated transcription coactivator 2; K16333	CREB regulated transcription coactivator 2 [Source:HGNC Symbol%3BAcc:HGNC:27301]
ENSG00000174132	10.16	7.88	8.39	8.54	6.92	8.39	0.169797912265345	2.30727375348123	0.349940746125609	0.723245925925441	5:100535304-100586741:+	FAM174A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 174 member A [Source:HGNC Symbol%3BAcc:HGNC:24943]
ENSG00000196352	20.23	19.79	19.66	18.96	18.68	19.87	0.0651608934324423	5.30417756158853	0.349943204869956	0.723245925925441	1:207321507-207386804:+	CD55	37;GO:0000139,cellular_component Golgi membrane;GO:0001618,molecular_function virus receptor activity;GO:0002376,biological_process immune system process;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006958,biological_process complement activation, classical pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007283,biological_process spermatogenesis;GO:0008289,molecular_function lipid binding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016324,cellular_component apical plasma membrane;GO:0030133,cellular_component transport vesicle;GO:0030449,biological_process regulation of complement activation;GO:0030667,cellular_component secretory granule membrane;GO:0031225,cellular_component anchored component of membrane;GO:0031664,biological_process regulation of lipopolysaccharide-mediated signaling pathway;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035743,biological_process CD4-positive, alpha-beta T cell cytokine production;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043312,biological_process neutrophil degranulation;GO:0043434,biological_process response to peptide hormone;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045730,biological_process respiratory burst;GO:0045916,biological_process negative regulation of complement activation;GO:0046718,biological_process viral entry into host cell;GO:0060137,biological_process maternal process involved in parturition;GO:0070062,cellular_component extracellular exosome;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:2000516,biological_process positive regulation of CD4-positive, alpha-beta T cell activation;GO:2000563,biological_process positive regulation of CD4-positive, alpha-beta T cell proliferation	DAF, CD55; decay accelerating factor; K04006	CD55 molecule (Cromer blood group) [Source:HGNC Symbol%3BAcc:HGNC:2665]
ENSG00000110514	9.96	10.86	10.89	10.29	10.35	9.90	0.0641251155307472	5.73345109348724	0.350001317153178	0.723245925925441	11:47269160-47330031:+	MADD	22;GO:0000187,biological_process activation of MAPK activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030295,molecular_function protein kinase activator activity;GO:0032483,biological_process regulation of Rab protein signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051726,biological_process regulation of cell cycle;GO:0061024,biological_process membrane organization;GO:0097194,biological_process execution phase of apoptosis;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001236,biological_process regulation of extrinsic apoptotic signaling pathway	NA	MAP kinase activating death domain [Source:HGNC Symbol%3BAcc:HGNC:6766]
ENSG00000167302	5.26	4.29	6.09	5.02	6.44	5.88	-0.127023566648756	3.68380716587772	0.3500548166111	0.723245925925441	17:81228276-81239091:-	TEPSIN	6;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0016607,cellular_component nuclear speck;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031965,cellular_component nuclear membrane	NA	TEPSIN%2C adaptor related protein complex 4 accessory protein [Source:HGNC Symbol%3BAcc:HGNC:26458]
ENSG00000042832	0.23	0.11	0.17	0.12	0.13	0.18	0.33689321804612	0.590834725725769	0.350099572648077	0.723245925925441	8:132866957-133134903:+	TG	9;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007165,biological_process signal transduction;GO:0015705,biological_process iodide transport;GO:0030878,biological_process thyroid gland development;GO:0031641,biological_process regulation of myelination;GO:0042403,biological_process thyroid hormone metabolic process;GO:0042446,biological_process hormone biosynthetic process	TG; thyroglobulin; K10809	thyroglobulin [Source:HGNC Symbol%3BAcc:HGNC:11764]
ENSG00000077549	211.68	230.87	205.77	204.16	210.15	212.18	0.0602370365523328	7.85292493014203	0.350166986512743	0.723245925925441	1:19338775-19485539:-	CAPZB	37;GO:0001669,cellular_component acrosomal vesicle;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005903,cellular_component brush border;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006928,biological_process movement of cell or subcellular component;GO:0007010,biological_process cytoskeleton organization;GO:0007596,biological_process blood coagulation;GO:0008290,cellular_component F-actin capping protein complex;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0014704,cellular_component intercalated disc;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030027,cellular_component lamellipodium;GO:0030030,biological_process cell projection organization;GO:0030032,biological_process lamellipodium assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030863,cellular_component cortical cytoskeleton;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0031175,biological_process neuron projection development;GO:0045296,molecular_function cadherin binding;GO:0048487,molecular_function beta-tubulin binding;GO:0048747,biological_process muscle fiber development;GO:0051015,molecular_function actin filament binding;GO:0051016,biological_process barbed-end actin filament capping;GO:0051490,biological_process negative regulation of filopodium assembly;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome;GO:0071203,cellular_component WASH complex;GO:0090036,biological_process regulation of protein kinase C signaling	CAPZB; capping protein (actin filament) muscle Z-line, beta; K10365	capping actin protein of muscle Z-line beta subunit [Source:HGNC Symbol%3BAcc:HGNC:1491]
ENSG00000177733	119.79	119.17	120.26	121.51	126.57	128.95	-0.0580653211208983	6.81399770009996	0.350187187831524	0.723245925925441	5:137745650-137754376:-	HNRNPA0	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006397,biological_process mRNA processing;GO:0006954,biological_process inflammatory response;GO:0016070,biological_process RNA metabolic process;GO:0017091,molecular_function AU-rich element binding;GO:0019901,molecular_function protein kinase binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032496,biological_process response to lipopolysaccharide;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization	NA	heterogeneous nuclear ribonucleoprotein A0 [Source:HGNC Symbol%3BAcc:HGNC:5030]
ENSG00000136450	173.02	167.36	172.46	171.31	184.22	182.95	-0.0580873563856697	7.16235412101874	0.350211514422227	0.723245925925441	17:58003359-58007346:-	SRSF1	32;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000395,biological_process mRNA 5'-splice site recognition;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0033120,biological_process positive regulation of RNA splicing;GO:0035145,cellular_component exon-exon junction complex;GO:0043422,molecular_function protein kinase B binding;GO:0044547,molecular_function DNA topoisomerase binding;GO:0048709,biological_process oligodendrocyte differentiation;GO:0050733,molecular_function RS domain binding;GO:0051028,biological_process mRNA transport;GO:0060048,biological_process cardiac muscle contraction;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097421,biological_process liver regeneration	SFRS1, ASF, SF2; splicing factor, arginine/serine-rich 1; K12890	serine and arginine rich splicing factor 1 [Source:HGNC Symbol%3BAcc:HGNC:10780]
ENSG00000016864	72.09	73.84	71.82	70.36	71.89	68.42	0.0587386601389179	6.31550528898027	0.350273775020342	0.723245925925441	3:52694487-52706032:-	GLT8D1	6;GO:0000271,biological_process polysaccharide biosynthetic process;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	glycosyltransferase 8 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24870]
ENSG00000171860	1.51	0.73	0.76	1.14	1.63	1.07	-0.304381157589423	0.866065864480934	0.350290381588959	0.723245925925441	12:8058301-8066471:-	C3AR1	26;GO:0002430,biological_process complement receptor mediated signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0004875,molecular_function complement receptor activity;GO:0004876,molecular_function complement component C3a receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008015,biological_process blood circulation;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010759,biological_process positive regulation of macrophage chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030449,biological_process regulation of complement activation;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0050900,biological_process leukocyte migration;GO:0060326,biological_process cell chemotaxis;GO:0090023,biological_process positive regulation of neutrophil chemotaxis	C3AR1; C3a anaphylatoxin chemotactic receptor; K04009	complement C3a receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:1319]
ENSG00000185808	51.27	46.38	45.58	53.88	47.44	51.93	-0.0835606931010041	4.57413506450927	0.350357312884207	0.723263815870891	21:37059169-37073170:-	PIGP	9;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0017176,molecular_function phosphatidylinositol N-acetylglucosaminyltransferase activity	PIGP, GPI19, DSCR5; phosphatidylinositol N-acetylglucosaminyltransferase subunit P; K03861	phosphatidylinositol glycan anchor biosynthesis class P [Source:HGNC Symbol%3BAcc:HGNC:3046]
ENSG00000142534	1779.46	1756.61	1851.63	1780.64	1710.92	1741.95	0.0537300021730987	9.7939150198165	0.350433403155742	0.72330060415235	19:49496364-49499689:+	RPS11	23;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	RP-S11e, RPS11; small subunit ribosomal protein S11e; K02949	ribosomal protein S11 [Source:HGNC Symbol%3BAcc:HGNC:10384]
ENSG00000182180	144.18	138.28	134.14	124.04	138.75	138.69	0.0652559884856463	5.8914701030838	0.350561287106821	0.723308091706154	10:73248842-73252693:-	MRPS16	13;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16; K02959	mitochondrial ribosomal protein S16 [Source:HGNC Symbol%3BAcc:HGNC:14048]
ENSG00000162227	9.42	10.96	9.03	9.51	10.08	7.84	0.107648169939432	4.1502011557279	0.350581683056233	0.723308091706154	11:62771302-62787342:+	TAF6L	17;GO:0000118,cellular_component histone deacetylase complex;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0030914,cellular_component STAGA complex;GO:0043966,biological_process histone H3 acetylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0070062,cellular_component extracellular exosome	TAF6; transcription initiation factor TFIID subunit 6; K03131	TATA-box binding protein associated factor 6 like [Source:HGNC Symbol%3BAcc:HGNC:17305]
ENSG00000178209	92.25	88.79	87.95	87.57	85.36	88.55	0.0526176856237243	10.3725400424836	0.350667928343223	0.723308091706154	8:143915146-143976734:-	PLEC	23;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005925,cellular_component focal adhesion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008307,molecular_function structural constituent of muscle;GO:0016528,cellular_component sarcoplasm;GO:0030054,cellular_component cell junction;GO:0030056,cellular_component hemidesmosome;GO:0030506,molecular_function ankyrin binding;GO:0031012,cellular_component extracellular matrix;GO:0031581,biological_process hemidesmosome assembly;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0043292,cellular_component contractile fiber;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	NA	plectin [Source:HGNC Symbol%3BAcc:HGNC:9069]
ENSG00000115652	46.96	50.64	44.59	46.70	47.42	42.33	0.0687665314505105	5.90626463359748	0.350670111648081	0.723308091706154	2:106093302-106194339:-	UXS1	16;GO:0003824,molecular_function catalytic activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033320,biological_process UDP-D-xylose biosynthetic process;GO:0042803,molecular_function protein homodimerization activity;GO:0048040,molecular_function UDP-glucuronate decarboxylase activity;GO:0050662,molecular_function coenzyme binding;GO:0051262,biological_process protein tetramerization;GO:0070062,cellular_component extracellular exosome;GO:0070403,molecular_function NAD+ binding	UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35]; K08678	UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol%3BAcc:HGNC:17729]
ENSG00000154122	24.67	20.87	22.86	22.49	18.64	23.80	0.0896474284320588	5.29670723166402	0.350816954448883	0.723490755204185	5:14704803-14871778:-	ANKH	16;GO:0001501,biological_process skeletal system development;GO:0005315,molecular_function inorganic phosphate transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006817,biological_process phosphate ion transport;GO:0007626,biological_process locomotory behavior;GO:0015114,molecular_function phosphate ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019867,cellular_component outer membrane;GO:0030500,biological_process regulation of bone mineralization;GO:0030504,molecular_function inorganic diphosphate transmembrane transporter activity;GO:0030505,biological_process inorganic diphosphate transport;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0055085,biological_process transmembrane transport	NA	ANKH inorganic pyrophosphate transport regulator [Source:HGNC Symbol%3BAcc:HGNC:15492]
ENSG00000182871	120.53	120.37	122.49	116.33	118.90	118.17	0.0520632833060502	9.32700498651933	0.350904365637938	0.723550812402611	21:45405136-45513720:+	COL18A1	23;GO:0001525,biological_process angiogenesis;GO:0001886,biological_process endothelial cell morphogenesis;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0007601,biological_process visual perception;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0042493,biological_process response to drug;GO:0046872,molecular_function metal ion binding;GO:0051599,biological_process response to hydrostatic pressure;GO:0070062,cellular_component extracellular exosome;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process	COL18A; collagen, type XVIII, alpha; K06823	collagen type XVIII alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2195]
ENSG00000112304	83.54	86.50	81.61	90.64	91.64	83.83	-0.0702721381484003	5.22634443943355	0.351139815241209	0.723916048262602	6:24667034-24705065:+	ACOT13	11;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006637,biological_process acyl-CoA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0047617,molecular_function acyl-CoA hydrolase activity;GO:0051289,biological_process protein homotetramerization;GO:0070062,cellular_component extracellular exosome	NA	acyl-CoA thioesterase 13 [Source:HGNC Symbol%3BAcc:HGNC:20999]
ENSG00000196705	5.06	5.51	4.17	4.44	4.73	4.38	0.124880854685092	3.21139085456841	0.351293897552686	0.724113442431333	19:21142023-21196053:+	ZNF431	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 431 [Source:HGNC Symbol%3BAcc:HGNC:20809]
ENSG00000136205	33.91	36.69	33.59	33.57	34.52	32.60	0.0599975679610275	7.34602895787656	0.351779164153257	0.724993319713494	7:47275153-47582558:-	TNS3	9;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016477,biological_process cell migration;GO:0030054,cellular_component cell junction;GO:0035556,biological_process intracellular signal transduction;GO:0048286,biological_process lung alveolus development	NA	tensin 3 [Source:HGNC Symbol%3BAcc:HGNC:21616]
ENSG00000124104	9.47	11.68	11.42	9.53	11.06	9.61	0.114763894408553	3.64561669518166	0.351888226032458	0.725097700820203	20:45833809-45843275:+	SNX21	11;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding	NA	sorting nexin family member 21 [Source:HGNC Symbol%3BAcc:HGNC:16154]
ENSG00000197302	7.69	8.03	8.08	8.51	8.74	8.59	-0.108019258128855	3.43182315228493	0.352360821152155	0.725830944580298	16:31713228-31794869:+	ZNF720	3;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	zinc finger protein 720 [Source:HGNC Symbol%3BAcc:HGNC:26987]
ENSG00000180336	0.44	0.56	0.20	0.39	0.63	0.49	-0.339708328668712	0.530760828757906	0.352361014423659	0.725830944580298	17:44656403-44690308:+	MEIOC	10;GO:0005737,cellular_component cytoplasm;GO:0006302,biological_process double-strand break repair;GO:0007130,biological_process synaptonemal complex assembly;GO:0007141,biological_process male meiosis I;GO:0007144,biological_process female meiosis I;GO:0007283,biological_process spermatogenesis;GO:0048255,biological_process mRNA stabilization;GO:0048599,biological_process oocyte development;GO:0051310,biological_process metaphase plate congression;GO:0051321,biological_process meiotic cell cycle	NA	meiosis specific with coiled-coil domain [Source:HGNC Symbol%3BAcc:HGNC:26670]
ENSG00000117862	157.28	149.53	171.51	171.10	156.67	178.24	-0.0679334671743513	6.4548211530425	0.352478372987549	0.725952222315323	1:52020130-52056171:-	TXNDC12	10;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0015037,molecular_function peptide disulfide oxidoreductase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019153,molecular_function protein-disulfide reductase (glutathione) activity;GO:0030154,biological_process cell differentiation;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	TXNDC12; protein-disulfide reductase (glutathione) [EC:1.8.4.2]; K05360	thioredoxin domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:24626]
ENSG00000138002	12.94	13.15	13.32	13.48	13.68	14.20	-0.0587723026987246	6.18023223856777	0.3525659482029	0.726012129237326	2:27444370-27489789:-	IFT172	36;GO:0001841,biological_process neural tube formation;GO:0001843,biological_process neural tube closure;GO:0001947,biological_process heart looping;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007219,biological_process Notch signaling pathway;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0008544,biological_process epidermis development;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0016485,biological_process protein processing;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021915,biological_process neural tube development;GO:0030992,cellular_component intraciliary transport particle B;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060021,biological_process palate development;GO:0060173,biological_process limb development;GO:0060271,biological_process cilium morphogenesis;GO:0060348,biological_process bone development;GO:0061525,biological_process hindgut development;GO:0070986,biological_process left/right axis specification;GO:0097225,cellular_component sperm midpiece;GO:0097228,cellular_component sperm principal piece;GO:0097542,cellular_component ciliary tip;GO:0097598,cellular_component sperm cytoplasmic droplet;GO:1903561,cellular_component extracellular vesicle;GO:1905515,biological_process non-motile cilium assembly	NA	intraflagellar transport 172 [Source:HGNC Symbol%3BAcc:HGNC:30391]
ENSG00000189308	8.68	7.32	7.96	7.63	7.97	7.07	0.0995034590000595	4.14124619047787	0.352867601718781	0.726363970475242	4:82909972-83012926:-	LIN54	8;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0051726,biological_process regulation of cell cycle	NA	lin-54 DREAM MuvB core complex component [Source:HGNC Symbol%3BAcc:HGNC:25397]
ENSG00000097007	37.92	37.59	37.84	39.11	39.84	39.85	-0.0557732099702652	7.09462405570393	0.352909022306907	0.726363970475242	9:130713945-130887675:+	ABL1	142;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000287,molecular_function magnesium ion binding;GO:0001784,molecular_function phosphotyrosine binding;GO:0001843,biological_process neural tube closure;GO:0001922,biological_process B-1 B cell homeostasis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002322,biological_process B cell proliferation involved in immune response;GO:0002333,biological_process transitional one stage B cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003785,molecular_function actin monomer binding;GO:0004515,molecular_function nicotinate-nucleotide adenylyltransferase activity;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0006909,biological_process phagocytosis;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0006979,biological_process response to oxidative stress;GO:0007050,biological_process cell cycle arrest;GO:0007155,biological_process cell adhesion;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008022,molecular_function protein C-terminus binding;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009791,biological_process post-embryonic development;GO:0010506,biological_process regulation of autophagy;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0017124,molecular_function SH3 domain binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019904,molecular_function protein domain specific binding;GO:0019905,molecular_function syntaxin binding;GO:0021587,biological_process cerebellum morphogenesis;GO:0022408,biological_process negative regulation of cell-cell adhesion;GO:0030035,biological_process microspike assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030100,biological_process regulation of endocytosis;GO:0030145,molecular_function manganese ion binding;GO:0030155,biological_process regulation of cell adhesion;GO:0030182,biological_process neuron differentiation;GO:0030425,cellular_component dendrite;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030516,biological_process regulation of axon extension;GO:0031113,biological_process regulation of microtubule polymerization;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031252,cellular_component cell leading edge;GO:0031965,cellular_component nuclear membrane;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0033690,biological_process positive regulation of osteoblast proliferation;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0034599,biological_process cellular response to oxidative stress;GO:0035791,biological_process platelet-derived growth factor receptor-beta signaling pathway;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042100,biological_process B cell proliferation;GO:0042127,biological_process regulation of cell proliferation;GO:0042169,molecular_function SH2 domain binding;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0045087,biological_process innate immune response;GO:0045184,biological_process establishment of protein localization;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046632,biological_process alpha-beta T cell differentiation;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0046875,molecular_function ephrin receptor binding;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0048668,biological_process collateral sprouting;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050798,biological_process activated T cell proliferation;GO:0050853,biological_process B cell receptor signaling pathway;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051015,molecular_function actin filament binding;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0051353,biological_process positive regulation of oxidoreductase activity;GO:0051444,biological_process negative regulation of ubiquitin-protein transferase activity;GO:0051726,biological_process regulation of cell cycle;GO:0051882,biological_process mitochondrial depolarization;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060563,biological_process neuroepithelial cell differentiation;GO:0070064,molecular_function proline-rich region binding;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0072358,biological_process cardiovascular system development;GO:0090135,biological_process actin filament branching;GO:0098794,cellular_component postsynapse;GO:1900042,biological_process positive regulation of interleukin-2 secretion;GO:1900272,biological_process negative regulation of long-term synaptic potentiation;GO:1900275,biological_process negative regulation of phospholipase C activity;GO:1901216,biological_process positive regulation of neuron death;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1902715,biological_process positive regulation of interferon-gamma secretion;GO:1903053,biological_process regulation of extracellular matrix organization;GO:1903351,biological_process cellular response to dopamine;GO:1904528,biological_process positive regulation of microtubule binding;GO:1904531,biological_process positive regulation of actin filament binding;GO:1905244,biological_process regulation of modification of synaptic structure;GO:1990051,biological_process activation of protein kinase C activity;GO:2000096,biological_process positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:2000145,biological_process regulation of cell motility;GO:2000249,biological_process regulation of actin cytoskeleton reorganization;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2000772,biological_process regulation of cellular senescence;GO:2000773,biological_process negative regulation of cellular senescence;GO:2001020,biological_process regulation of response to DNA damage stimulus	ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]; K06619	ABL proto-oncogene 1%2C non-receptor tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:76]
ENSG00000165060	7.60	6.57	6.16	6.71	8.73	7.57	-0.161068920753595	2.32222114049354	0.352912358489985	0.726363970475242	9:69035258-69100178:+	FXN	42;GO:0004322,molecular_function ferroxidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006119,biological_process oxidative phosphorylation;GO:0006783,biological_process heme biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007005,biological_process mitochondrion organization;GO:0007628,biological_process adult walking behavior;GO:0008198,molecular_function ferrous iron binding;GO:0008199,molecular_function ferric iron binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009060,biological_process aerobic respiration;GO:0009792,biological_process embryo development ending in birth or egg hatching;GO:0010039,biological_process response to iron ion;GO:0010722,biological_process regulation of ferrochelatase activity;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0016491,molecular_function oxidoreductase activity;GO:0016540,biological_process protein autoprocessing;GO:0018283,biological_process iron incorporation into metallo-sulfur cluster;GO:0019230,biological_process proprioception;GO:0030307,biological_process positive regulation of cell growth;GO:0034986,molecular_function iron chaperone activity;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0044281,biological_process small molecule metabolic process;GO:0046621,biological_process negative regulation of organ growth;GO:0046872,molecular_function metal ion binding;GO:0051349,biological_process positive regulation of lyase activity;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055072,biological_process iron ion homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:1904231,biological_process positive regulation of succinate dehydrogenase activity;GO:1904234,biological_process positive regulation of aconitate hydratase activity	NA	frataxin [Source:HGNC Symbol%3BAcc:HGNC:3951]
ENSG00000182872	24.91	22.31	25.57	25.11	22.08	22.80	0.0712859233316305	6.15565787430031	0.353042432709567	0.726494332395315	X:47144868-47186813:+	RBM10	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0008150,biological_process biological_process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0032403,molecular_function protein complex binding;GO:0034391,biological_process regulation of smooth muscle cell apoptotic process;GO:0034393,biological_process positive regulation of smooth muscle cell apoptotic process;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization	NA	RNA binding motif protein 10 [Source:HGNC Symbol%3BAcc:HGNC:9896]
ENSG00000033867	13.19	10.97	13.65	12.57	11.47	12.13	0.0809461419067928	5.60293768891758	0.353136011572247	0.726494332395315	3:27372720-27484420:-	SLC4A7	26;GO:0005215,molecular_function transporter activity;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006820,biological_process anion transport;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0008510,molecular_function sodium:bicarbonate symporter activity;GO:0015293,molecular_function symporter activity;GO:0015698,biological_process inorganic anion transport;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032420,cellular_component stereocilium;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0060117,biological_process auditory receptor cell development;GO:0098656,biological_process anion transmembrane transport	NA	solute carrier family 4 member 7 [Source:HGNC Symbol%3BAcc:HGNC:11033]
ENSG00000064490	50.40	47.45	49.55	51.27	53.16	51.07	-0.0627139848211756	5.45715515849639	0.353169500017315	0.726494332395315	19:19192228-19201869:+	RFXANK	14;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007265,biological_process Ras protein signal transduction;GO:0042826,molecular_function histone deacetylase binding;GO:0045171,cellular_component intercellular bridge;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	RFXANK; regulatory factor X-associated ankyrin-containing protein; K08062	regulatory factor X associated ankyrin containing protein [Source:HGNC Symbol%3BAcc:HGNC:9987]
ENSG00000115484	183.01	184.63	177.47	191.65	190.71	188.04	-0.0538766945375635	8.23342890159298	0.353209803915711	0.726494332395315	2:61868088-61888804:-	CCT4	31;GO:0000166,molecular_function nucleotide binding;GO:0002199,cellular_component zona pellucida receptor complex;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0042470,cellular_component melanosome;GO:0042995,cellular_component cell projection;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044297,cellular_component cell body;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051973,biological_process positive regulation of telomerase activity;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0090666,biological_process scaRNA localization to Cajal body;GO:1901998,biological_process toxin transport;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	chaperonin containing TCP1 subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:1617]
ENSG00000178814	1.72	1.47	1.88	1.51	1.81	2.46	-0.172308360536546	2.94892536589437	0.353299911368064	0.726559277636146	8:144051265-144063965:-	OPLAH	8;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0017168,molecular_function 5-oxoprolinase (ATP-hydrolyzing) activity	OPLAH, OXP1, oplAH; 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9]; K01469	5-oxoprolinase (ATP-hydrolysing) [Source:HGNC Symbol%3BAcc:HGNC:8149]
ENSG00000143198	136.74	153.62	144.46	140.17	143.47	135.52	0.0624040083430016	6.32661877400119	0.35348585471682	0.726704758228541	1:165630860-165661796:+	MGST3	19;GO:0004364,molecular_function glutathione transferase activity;GO:0004601,molecular_function peroxidase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0007165,biological_process signal transduction;GO:0010243,biological_process response to organonitrogen compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	microsomal glutathione S-transferase 3 [Source:HGNC Symbol%3BAcc:HGNC:7064]
ENSG00000129493	4.39	5.50	4.19	4.19	4.72	4.33	0.0934407268125086	4.82998047829292	0.35348774109272	0.726704758228541	14:31291790-31420582:-	HEATR5A	NA	NA	HEAT repeat containing 5A [Source:HGNC Symbol%3BAcc:HGNC:20276]
ENSG00000172007	15.11	15.02	16.82	16.78	17.88	16.48	-0.107586638873681	3.51192241523205	0.353726685773711	0.726838312197767	4:139453231-139476609:+	RAB33B	20;GO:0000042,biological_process protein targeting to Golgi;GO:0000045,biological_process autophagosome assembly;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0006810,biological_process transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0048705,biological_process skeletal system morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:1903358,biological_process regulation of Golgi organization;GO:1903434,biological_process negative regulation of constitutive secretory pathway;GO:2000156,biological_process regulation of retrograde vesicle-mediated transport, Golgi to ER;GO:2000785,biological_process regulation of autophagosome assembly	RAB33B; Ras-related protein Rab-33B; K07920	RAB33B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:16075]
ENSG00000096746	126.01	124.84	126.57	132.14	130.42	132.98	-0.0557704971075778	7.06584101391499	0.353730410945414	0.726838312197767	10:68331173-68343191:+	HNRNPH3	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030855,biological_process epithelial cell differentiation	NA	heterogeneous nuclear ribonucleoprotein H3 [Source:HGNC Symbol%3BAcc:HGNC:5043]
ENSG00000102401	39.01	38.75	34.89	35.89	36.82	35.56	0.0674780758722921	5.39261026613556	0.353757143461127	0.726838312197767	X:101622796-101627843:+	ARMCX3	5;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0034613,biological_process cellular protein localization;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	armadillo repeat containing%2C X-linked 3 [Source:HGNC Symbol%3BAcc:HGNC:24065]
ENSG00000186448	5.13	5.12	5.80	5.83	5.28	6.15	-0.0914172336264003	4.18820598889721	0.353786923571973	0.726838312197767	3:44584887-44648471:+	ZNF197	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 197 [Source:HGNC Symbol%3BAcc:HGNC:12988]
ENSG00000128645	2.08	2.14	1.20	1.98	2.24	2.36	-0.283380318467668	1.08099486457909	0.353982095489696	0.727070784786684	2:176188578-176190907:+	HOXD1	10;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0019233,biological_process sensory perception of pain;GO:0030182,biological_process neuron differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048706,biological_process embryonic skeletal system development	NA	homeobox D1 [Source:HGNC Symbol%3BAcc:HGNC:5132]
ENSG00000163428	7.74	6.61	8.07	6.05	7.09	7.52	0.137931256556702	3.03121914398159	0.354034042499334	0.727070784786684	3:120324508-120349339:-	LRRC58	NA	NA	leucine rich repeat containing 58 [Source:HGNC Symbol%3BAcc:HGNC:26968]
ENSG00000188372	2.65	2.85	3.21	4.29	2.96	2.85	-0.200327445198342	2.08957307380312	0.354100455696413	0.727070784786684	7:76397517-76442071:+	ZP3	45;GO:0001809,biological_process positive regulation of type IV hypersensitivity;GO:0001825,biological_process blastocyst formation;GO:0002081,cellular_component outer acrosomal membrane;GO:0002455,biological_process humoral immune response mediated by circulating immunoglobulin;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0002922,biological_process positive regulation of humoral immune response;GO:0005384,molecular_function manganese ion transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005771,cellular_component multivesicular body;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006828,biological_process manganese ion transport;GO:0007338,biological_process single fertilization;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0010513,biological_process positive regulation of phosphatidylinositol biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030141,cellular_component secretory granule;GO:0030246,molecular_function carbohydrate binding;GO:0031012,cellular_component extracellular matrix;GO:0032190,molecular_function acrosin binding;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0033157,biological_process regulation of intracellular protein transport;GO:0035636,biological_process multi-organism signaling;GO:0035803,biological_process egg coat formation;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048599,biological_process oocyte development;GO:0050729,biological_process positive regulation of inflammatory response;GO:0071421,biological_process manganese ion transmembrane transport;GO:2000344,biological_process positive regulation of acrosome reaction;GO:2000360,biological_process negative regulation of binding of sperm to zona pellucida;GO:2000368,biological_process positive regulation of acrosomal vesicle exocytosis;GO:2000386,biological_process positive regulation of ovarian follicle development;GO:2000388,biological_process positive regulation of antral ovarian follicle growth	NA	zona pellucida glycoprotein 3 [Source:HGNC Symbol%3BAcc:HGNC:13189]
ENSG00000164414	31.51	29.59	28.03	28.59	28.51	28.31	0.0741904887901003	4.88615881302602	0.354170793930605	0.727070784786684	6:87470622-87512336:+	SLC35A1	13;GO:0000139,cellular_component Golgi membrane;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005456,molecular_function CMP-N-acetylneuraminate transmembrane transporter activity;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015782,biological_process CMP-N-acetylneuraminate transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member A1 [Source:HGNC Symbol%3BAcc:HGNC:11021]
ENSG00000204618	5.61	4.78	5.37	5.65	4.21	4.52	0.15242506115284	2.69957097929773	0.354192945750832	0.727070784786684	6:30070265-30075887:-	RNF39	4;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 39 [Source:HGNC Symbol%3BAcc:HGNC:18064]
ENSG00000133243	57.81	57.93	58.57	60.64	59.03	63.29	-0.0582917999233898	6.77954254715369	0.354300484163344	0.727074776368482	19:1985437-2034881:-	BTBD2	10;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0022008,biological_process neurogenesis;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	NA	BTB domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:15504]
ENSG00000151893	12.06	12.35	11.53	8.88	12.55	11.82	0.121382881266267	3.71919240567784	0.354312037561665	0.727074776368482	10:118674166-118755249:-	CACUL1	11;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0019901,molecular_function protein kinase binding;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	CDK2 associated cullin domain 1 [Source:HGNC Symbol%3BAcc:HGNC:23727]
ENSG00000101608	895.26	920.02	878.78	944.85	943.10	929.89	-0.0532609833588478	8.9314614383907	0.354385505399325	0.727105335292863	18:3247480-3256236:+	MYL12A	9;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006936,biological_process muscle contraction;GO:0016459,cellular_component myosin complex;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation	MYL12; myosin regulatory light chain 12; K12757	myosin light chain 12A [Source:HGNC Symbol%3BAcc:HGNC:16701]
ENSG00000213024	45.19	39.00	41.36	44.94	42.76	44.86	-0.0636744671307104	6.07970486898901	0.35459443740287	0.727413774827604	19:49906824-49929763:-	NUP62	75;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0003682,molecular_function chromatin binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005642,cellular_component annulate lamellae;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006110,biological_process regulation of glycolytic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007098,biological_process centrosome cycle;GO:0007100,biological_process mitotic centrosome separation;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0007569,biological_process cell aging;GO:0008219,biological_process cell death;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0009966,biological_process regulation of signal transduction;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0019894,molecular_function kinesin binding;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030544,molecular_function Hsp70 protein binding;GO:0031965,cellular_component nuclear membrane;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042169,molecular_function SH2 domain binding;GO:0042306,biological_process regulation of protein import into nucleus;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043657,cellular_component host cell;GO:0044613,cellular_component nuclear pore central transport channel;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046578,biological_process regulation of Ras protein signal transduction;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046601,biological_process positive regulation of centriole replication;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0051028,biological_process mRNA transport;GO:0051169,biological_process nuclear transport;GO:0051425,molecular_function PTB domain binding;GO:0051879,molecular_function Hsp90 protein binding;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070208,biological_process protein heterotrimerization;GO:0071426,biological_process ribonucleoprotein complex export from nucleus;GO:0072686,cellular_component mitotic spindle;GO:0075733,biological_process intracellular transport of virus;GO:0090543,cellular_component Flemming body;GO:0098534,biological_process centriole assembly;GO:1900034,biological_process regulation of cellular response to heat;GO:1903438,biological_process positive regulation of mitotic cytokinetic process;GO:1904781,biological_process positive regulation of protein localization to centrosome	NUP62, NSP1; nuclear pore complex protein Nup62; K14306	nucleoporin 62 [Source:HGNC Symbol%3BAcc:HGNC:8066]
ENSG00000197020	3.12	2.78	3.22	2.95	2.78	2.58	0.156639224035405	2.47184849807415	0.354669522967992	0.727447585690959	19:21722765-21767628:-	ZNF100	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 100 [Source:HGNC Symbol%3BAcc:HGNC:12880]
ENSG00000111110	2.29	4.03	2.91	3.79	3.49	3.24	-0.200160069359987	2.37239408571836	0.355010057432892	0.728025746392614	12:62643981-62935037:-	PPM1H	8;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0016787,molecular_function hydrolase activity	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1H [Source:HGNC Symbol%3BAcc:HGNC:18583]
ENSG00000196700	7.23	7.29	7.67	6.74	7.09	7.31	0.0822477229401418	4.28424011884858	0.355199497632545	0.728210185588959	20:63956701-63969865:-	ZNF512B	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 512B [Source:HGNC Symbol%3BAcc:HGNC:29212]
ENSG00000068120	53.99	54.90	55.23	54.42	61.13	57.20	-0.0621658061856119	6.64527709345383	0.35526050943105	0.728210185588959	17:42561466-42566277:+	COASY	19;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004140,molecular_function dephospho-CoA kinase activity;GO:0004595,molecular_function pantetheine-phosphate adenylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0008152,biological_process metabolic process;GO:0009058,biological_process biosynthetic process;GO:0009108,biological_process coenzyme biosynthetic process;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0070062,cellular_component extracellular exosome	COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase [EC:2.7.7.3 2.7.1.24]; K02318	Coenzyme A synthase [Source:HGNC Symbol%3BAcc:HGNC:29932]
ENSG00000183579	6.67	5.79	5.95	4.96	6.75	5.48	0.114197659565238	4.07303750692047	0.355310987039343	0.728210185588959	22:28883591-29057487:+	ZNRF3	20;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0038018,biological_process Wnt receptor catabolic process;GO:0046872,molecular_function metal ion binding;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0072089,biological_process stem cell proliferation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000051,biological_process negative regulation of non-canonical Wnt signaling pathway	ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27]; K16273	zinc and ring finger 3 [Source:HGNC Symbol%3BAcc:HGNC:18126]
ENSG00000164690	7.15	5.78	6.78	6.48	5.70	6.24	0.119266596905112	3.51558881221151	0.355420322333984	0.728210185588959	7:155799985-155812273:-	SHH	200;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001525,biological_process angiogenesis;GO:0001569,biological_process patterning of blood vessels;GO:0001570,biological_process vasculogenesis;GO:0001656,biological_process metanephros development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001708,biological_process cell fate specification;GO:0001755,biological_process neural crest cell migration;GO:0001822,biological_process kidney development;GO:0001942,biological_process hair follicle development;GO:0001944,biological_process vasculature development;GO:0001947,biological_process heart looping;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002076,biological_process osteoblast development;GO:0002320,biological_process lymphoid progenitor cell differentiation;GO:0003140,biological_process determination of left/right asymmetry in lateral mesoderm;GO:0005113,molecular_function patched binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006897,biological_process endocytosis;GO:0007224,biological_process smoothened signaling pathway;GO:0007228,biological_process positive regulation of hh target transcription factor activity;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007389,biological_process pattern specification process;GO:0007398,biological_process ectoderm development;GO:0007405,biological_process neuroblast proliferation;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0007418,biological_process ventral midline development;GO:0007442,biological_process hindgut morphogenesis;GO:0007507,biological_process heart development;GO:0007596,biological_process blood coagulation;GO:0008209,biological_process androgen metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009790,biological_process embryo development;GO:0009880,biological_process embryonic pattern specification;GO:0009949,biological_process polarity specification of anterior/posterior axis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009986,cellular_component cell surface;GO:0010463,biological_process mesenchymal cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0014003,biological_process oligodendrocyte development;GO:0014706,biological_process striated muscle tissue development;GO:0014858,biological_process positive regulation of skeletal muscle cell proliferation;GO:0014902,biological_process myotube differentiation;GO:0016015,molecular_function morphogen activity;GO:0016020,cellular_component membrane;GO:0016539,biological_process intein-mediated protein splicing;GO:0016787,molecular_function hydrolase activity;GO:0021513,biological_process spinal cord dorsal/ventral patterning;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021794,biological_process thalamus development;GO:0021871,biological_process forebrain regionalization;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021924,biological_process cell proliferation in external granule layer;GO:0021930,biological_process cerebellar granule cell precursor proliferation;GO:0021938,biological_process smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation;GO:0021940,biological_process positive regulation of cerebellar granule cell precursor proliferation;GO:0021978,biological_process telencephalon regionalization;GO:0030010,biological_process establishment of cell polarity;GO:0030162,biological_process regulation of proteolysis;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030323,biological_process respiratory tube development;GO:0030324,biological_process lung development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030336,biological_process negative regulation of cell migration;GO:0030539,biological_process male genitalia development;GO:0030850,biological_process prostate gland development;GO:0030878,biological_process thyroid gland development;GO:0030900,biological_process forebrain development;GO:0030901,biological_process midbrain development;GO:0030902,biological_process hindbrain development;GO:0031016,biological_process pancreas development;GO:0031069,biological_process hair follicle morphogenesis;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033077,biological_process T cell differentiation in thymus;GO:0033089,biological_process positive regulation of T cell differentiation in thymus;GO:0033092,biological_process positive regulation of immature T cell proliferation in thymus;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0034504,biological_process protein localization to nucleus;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0042127,biological_process regulation of cell proliferation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042476,biological_process odontogenesis;GO:0042481,biological_process regulation of odontogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043010,biological_process camera-type eye development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043237,molecular_function laminin-1 binding;GO:0043369,biological_process CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0043588,biological_process skin development;GO:0045059,biological_process positive thymic T cell selection;GO:0045060,biological_process negative thymic T cell selection;GO:0045109,biological_process intermediate filament organization;GO:0045121,cellular_component membrane raft;GO:0045165,biological_process cell fate commitment;GO:0045445,biological_process myoblast differentiation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046638,biological_process positive regulation of alpha-beta T cell differentiation;GO:0046639,biological_process negative regulation of alpha-beta T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048468,biological_process cell development;GO:0048538,biological_process thymus development;GO:0048546,biological_process digestive tract morphogenesis;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048568,biological_process embryonic organ development;GO:0048589,biological_process developmental growth;GO:0048598,biological_process embryonic morphogenesis;GO:0048617,biological_process embryonic foregut morphogenesis;GO:0048643,biological_process positive regulation of skeletal muscle tissue development;GO:0048645,biological_process organ formation;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048663,biological_process neuron fate commitment;GO:0048706,biological_process embryonic skeletal system development;GO:0048709,biological_process oligodendrocyte differentiation;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048839,biological_process inner ear development;GO:0048856,biological_process anatomical structure development;GO:0048859,biological_process formation of anatomical boundary;GO:0048864,biological_process stem cell development;GO:0051146,biological_process striated muscle cell differentiation;GO:0051155,biological_process positive regulation of striated muscle cell differentiation;GO:0051781,biological_process positive regulation of cell division;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060021,biological_process palate development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060173,biological_process limb development;GO:0060174,biological_process limb bud formation;GO:0060425,biological_process lung morphogenesis;GO:0060428,biological_process lung epithelium development;GO:0060438,biological_process trachea development;GO:0060439,biological_process trachea morphogenesis;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060442,biological_process branching involved in prostate gland morphogenesis;GO:0060445,biological_process branching involved in salivary gland morphogenesis;GO:0060447,biological_process bud outgrowth involved in lung branching;GO:0060458,biological_process right lung development;GO:0060459,biological_process left lung development;GO:0060463,biological_process lung lobe morphogenesis;GO:0060484,biological_process lung-associated mesenchyme development;GO:0060516,biological_process primary prostatic bud elongation;GO:0060523,biological_process prostate epithelial cord elongation;GO:0060662,biological_process salivary gland cavitation;GO:0060664,biological_process epithelial cell proliferation involved in salivary gland morphogenesis;GO:0060684,biological_process epithelial-mesenchymal cell signaling;GO:0060685,biological_process regulation of prostatic bud formation;GO:0060738,biological_process epithelial-mesenchymal signaling involved in prostate gland development;GO:0060768,biological_process regulation of epithelial cell proliferation involved in prostate gland development;GO:0060769,biological_process positive regulation of epithelial cell proliferation involved in prostate gland development;GO:0060782,biological_process regulation of mesenchymal cell proliferation involved in prostate gland development;GO:0060783,biological_process mesenchymal smoothened signaling pathway involved in prostate gland development;GO:0060840,biological_process artery development;GO:0060916,biological_process mesenchymal cell proliferation involved in lung development;GO:0061053,biological_process somite development;GO:0061189,biological_process positive regulation of sclerotome development;GO:0071285,biological_process cellular response to lithium ion;GO:0071542,biological_process dopaminergic neuron differentiation;GO:0072001,biological_process renal system development;GO:0072136,biological_process metanephric mesenchymal cell proliferation involved in metanephros development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090370,biological_process negative regulation of cholesterol efflux;GO:0097190,biological_process apoptotic signaling pathway;GO:1900175,biological_process regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:1900180,biological_process regulation of protein localization to nucleus;GO:1904339,biological_process negative regulation of dopaminergic neuron differentiation;GO:1905327,biological_process tracheoesophageal septum formation;GO:2000062,biological_process negative regulation of ureter smooth muscle cell differentiation;GO:2000063,biological_process positive regulation of ureter smooth muscle cell differentiation;GO:2000357,biological_process negative regulation of kidney smooth muscle cell differentiation;GO:2000358,biological_process positive regulation of kidney smooth muscle cell differentiation;GO:2000729,biological_process positive regulation of mesenchymal cell proliferation involved in ureter development;GO:2001054,biological_process negative regulation of mesenchymal cell apoptotic process	SHH; sonic hedgehog; K11988	sonic hedgehog [Source:HGNC Symbol%3BAcc:HGNC:10848]
ENSG00000126062	27.30	25.96	30.75	25.60	27.08	27.58	0.081550290336347	4.85948046055738	0.355437472332589	0.728210185588959	3:50354748-50359610:-	TMEM115	18;GO:0000139,cellular_component Golgi membrane;GO:0003674,molecular_function molecular_function;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0008285,biological_process negative regulation of cell proliferation;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032580,cellular_component Golgi cisterna membrane;GO:0042802,molecular_function identical protein binding	NA	transmembrane protein 115 [Source:HGNC Symbol%3BAcc:HGNC:30055]
ENSG00000112282	16.85	17.08	15.45	14.55	16.61	16.32	0.0669090194409586	6.07758969427303	0.355451986988118	0.728210185588959	6:131573965-131628229:-	MED23	9;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter	NA	mediator complex subunit 23 [Source:HGNC Symbol%3BAcc:HGNC:2372]
ENSG00000068903	31.89	31.19	37.25	31.60	32.93	31.65	0.0756946944484019	5.5161468844424	0.355636937506607	0.728468862255696	19:38878554-38899862:-	SIRT2	111;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000781,cellular_component chromosome, telomeric region;GO:0002376,biological_process immune system process;GO:0003682,molecular_function chromatin binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005677,cellular_component chromatin silencing complex;GO:0005694,cellular_component chromosome;GO:0005720,cellular_component nuclear heterochromatin;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006342,biological_process chromatin silencing;GO:0006348,biological_process chromatin silencing at telomere;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006471,biological_process protein ADP-ribosylation;GO:0006476,biological_process protein deacetylation;GO:0006914,biological_process autophagy;GO:0007049,biological_process cell cycle;GO:0007096,biological_process regulation of exit from mitosis;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010507,biological_process negative regulation of autophagy;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016458,biological_process gene silencing;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0017136,molecular_function NAD-dependent histone deacetylase activity;GO:0021762,biological_process substantia nigra development;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030154,biological_process cell differentiation;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0031641,biological_process regulation of myelination;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033010,cellular_component paranodal junction;GO:0033270,cellular_component paranode region of axon;GO:0033558,molecular_function protein deacetylase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0034979,molecular_function NAD-dependent protein deacetylase activity;GO:0034983,biological_process peptidyl-lysine deacetylation;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042325,biological_process regulation of phosphorylation;GO:0042826,molecular_function histone deacetylase binding;GO:0042903,molecular_function tubulin deacetylase activity;GO:0042995,cellular_component cell projection;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043204,cellular_component perikaryon;GO:0043209,cellular_component myelin sheath;GO:0043219,cellular_component lateral loop;GO:0043220,cellular_component Schmidt-Lanterman incisure;GO:0043388,biological_process positive regulation of DNA binding;GO:0043491,biological_process protein kinase B signaling;GO:0044224,cellular_component juxtaparanode region of axon;GO:0044242,biological_process cellular lipid catabolic process;GO:0045087,biological_process innate immune response;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045836,biological_process positive regulation of meiotic nuclear division;GO:0045843,biological_process negative regulation of striated muscle tissue development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046970,molecular_function NAD-dependent histone deacetylase activity (H4-K16 specific);GO:0048012,biological_process hepatocyte growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048487,molecular_function beta-tubulin binding;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051726,biological_process regulation of cell cycle;GO:0051775,biological_process response to redox state;GO:0051781,biological_process positive regulation of cell division;GO:0051987,biological_process positive regulation of attachment of spindle microtubules to kinetochore;GO:0061428,biological_process negative regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061433,biological_process cellular response to caloric restriction;GO:0070403,molecular_function NAD+ binding;GO:0070446,biological_process negative regulation of oligodendrocyte progenitor proliferation;GO:0070932,biological_process histone H3 deacetylation;GO:0070933,biological_process histone H4 deacetylation;GO:0071219,biological_process cellular response to molecule of bacterial origin;GO:0071456,biological_process cellular response to hypoxia;GO:0071872,biological_process cellular response to epinephrine stimulus;GO:0072686,cellular_component mitotic spindle;GO:0072687,cellular_component meiotic spindle;GO:0090042,biological_process tubulin deacetylation;GO:0097386,cellular_component glial cell projection;GO:1900119,biological_process positive regulation of execution phase of apoptosis;GO:1900195,biological_process positive regulation of oocyte maturation;GO:1900226,biological_process negative regulation of NLRP3 inflammasome complex assembly;GO:1900425,biological_process negative regulation of defense response to bacterium;GO:1901026,biological_process ripoptosome assembly involved in necroptotic process;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2000777,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia	SIRT2, SIR2L2; NAD+-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]; K11412	sirtuin 2 [Source:HGNC Symbol%3BAcc:HGNC:10886]
ENSG00000117640	28.49	32.85	31.57	31.76	29.95	26.57	0.0827249732945787	4.9996429364005	0.355724200644636	0.728527388649047	1:25818639-25832942:+	MTFR1L	4;GO:0000266,biological_process mitochondrial fission;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0009060,biological_process aerobic respiration	NA	mitochondrial fission regulator 1 like [Source:HGNC Symbol%3BAcc:HGNC:28836]
ENSG00000157895	9.55	8.45	9.42	7.87	9.08	8.56	0.124182302184518	3.11237501346338	0.355843225380487	0.728535132711724	12:121000485-121016502:-	C12orf43	1;GO:0005515,molecular_function protein binding	NA	chromosome 12 open reading frame 43 [Source:HGNC Symbol%3BAcc:HGNC:25719]
ENSG00000036257	45.58	43.19	43.54	44.66	47.14	47.15	-0.0581694743352676	6.78527737343479	0.355845364507466	0.728535132711724	2:224470149-224585397:-	CUL3	59;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000278,biological_process mitotic cell cycle;GO:0000902,biological_process cell morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001831,biological_process trophectodermal cellular morphogenesis;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005112,molecular_function Notch binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005827,cellular_component polar microtubule;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007050,biological_process cell cycle arrest;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007369,biological_process gastrulation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016192,biological_process vesicle-mediated transport;GO:0016477,biological_process cell migration;GO:0016567,biological_process protein ubiquitination;GO:0017145,biological_process stem cell division;GO:0030030,biological_process cell projection organization;GO:0030332,molecular_function cyclin binding;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031208,molecular_function POZ domain binding;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0040016,biological_process embryonic cleavage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043149,biological_process stress fiber assembly;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0044346,biological_process fibroblast apoptotic process;GO:0045842,biological_process positive regulation of mitotic metaphase/anaphase transition;GO:0046982,molecular_function protein heterodimerization activity;GO:0048208,biological_process COPII vesicle coating;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0071630,biological_process nucleus-associated proteasomal ubiquitin-dependent protein catabolic process;GO:0072576,biological_process liver morphogenesis;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097193,biological_process intrinsic apoptotic signaling pathway	CUL3; cullin 3; K03869	cullin 3 [Source:HGNC Symbol%3BAcc:HGNC:2553]
ENSG00000147533	32.26	30.78	33.09	31.50	32.45	26.20	0.109869486570403	3.70785844625255	0.355985848969392	0.728702563202021	8:41490395-41510980:+	GOLGA7	16;GO:0000139,cellular_component Golgi membrane;GO:0002178,cellular_component palmitoyltransferase complex;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006612,biological_process protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0018230,biological_process peptidyl-L-cysteine S-palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0031228,cellular_component intrinsic component of Golgi membrane;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043312,biological_process neutrophil degranulation;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen	NA	golgin A7 [Source:HGNC Symbol%3BAcc:HGNC:24876]
ENSG00000080823	14.66	15.92	15.47	17.65	15.03	16.48	-0.0861996336397976	4.57190166416479	0.3561711460589	0.728961654745115	14:102224499-102305200:-	MOK	19;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle;GO:0097546,cellular_component ciliary base	NA	MOK protein kinase [Source:HGNC Symbol%3BAcc:HGNC:9833]
ENSG00000130402	315.06	344.19	319.97	309.79	335.71	300.38	0.0615875389103918	9.87400360842895	0.356396790456163	0.729303224519016	19:38647648-38731583:+	ACTN4	58;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001666,biological_process response to hypoxia;GO:0001725,cellular_component stress fiber;GO:0001882,molecular_function nucleoside binding;GO:0002576,biological_process platelet degranulation;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005903,cellular_component brush border;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016604,cellular_component nuclear body;GO:0030018,cellular_component Z disc;GO:0030050,biological_process vesicle transport along actin filament;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030863,cellular_component cortical cytoskeleton;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031143,cellular_component pseudopodium;GO:0031490,molecular_function chromatin DNA binding;GO:0032403,molecular_function protein complex binding;GO:0032417,biological_process positive regulation of sodium:proton antiporter activity;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035357,biological_process peroxisome proliferator activated receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0042974,molecular_function retinoic acid receptor binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043005,cellular_component neuron projection;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048549,biological_process positive regulation of pinocytosis;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051271,biological_process negative regulation of cellular component movement;GO:0051272,biological_process positive regulation of cellular component movement;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1902396,biological_process protein localization to bicellular tight junction;GO:1903506,biological_process regulation of nucleic acid-templated transcription	ACTN1_4; actinin alpha 1/4; K05699	actinin alpha 4 [Source:HGNC Symbol%3BAcc:HGNC:166]
ENSG00000170222	8.69	5.79	6.37	8.42	6.78	8.32	-0.150034256666792	2.98383166464426	0.356537370381538	0.729450862290511	17:10697593-10711233:+	ADPRM	8;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047631,molecular_function ADP-ribose diphosphatase activity;GO:0047734,molecular_function CDP-glycerol diphosphatase activity	ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.13 3.6.1.16 3.6.1.53]; K01517	ADP-ribose/CDP-alcohol diphosphatase%2C manganese dependent [Source:HGNC Symbol%3BAcc:HGNC:30925]
ENSG00000139597	3.92	4.24	4.32	4.86	4.33	4.74	-0.151155209669533	2.51402198528318	0.356586468410442	0.729450862290511	13:32400722-32428311:-	N4BP2L1	NA	NA	NEDD4 binding protein 2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:25037]
ENSG00000105698	48.72	46.16	48.31	46.92	45.13	46.68	0.0587926343578886	6.24982954191616	0.356788609013954	0.729672079838424	19:35268977-35279821:+	USF2	23;GO:0000430,biological_process regulation of transcription from RNA polymerase II promoter by glucose;GO:0000432,biological_process positive regulation of transcription from RNA polymerase II promoter by glucose;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007595,biological_process lactation;GO:0019086,biological_process late viral transcription;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0055088,biological_process lipid homeostasis	NA	upstream transcription factor 2%2C c-fos interacting [Source:HGNC Symbol%3BAcc:HGNC:12594]
ENSG00000166920	41.12	29.58	42.70	52.83	31.35	43.38	-0.152346680669344	4.23584611667669	0.356815666240655	0.729672079838424	15:45430528-45448761:+	C15orf48	7;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	chromosome 15 open reading frame 48 [Source:HGNC Symbol%3BAcc:HGNC:29898]
ENSG00000114573	22.05	22.90	22.08	20.93	22.24	21.43	0.0632229922228816	5.38869848615943	0.356870957600828	0.729672079838424	3:113747018-113812056:+	ATP6V1A	27;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005902,cellular_component microvillus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008286,biological_process insulin receptor signaling pathway;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016241,biological_process regulation of macroautophagy;GO:0016324,cellular_component apical plasma membrane;GO:0016469,cellular_component proton-transporting two-sector ATPase complex;GO:0016787,molecular_function hydrolase activity;GO:0033180,cellular_component proton-transporting V-type ATPase, V1 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0036295,biological_process cellular response to increased oxygen levels;GO:0043209,cellular_component myelin sheath;GO:0046034,biological_process ATP metabolic process;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A [EC:7.1.2.2]; K02145	ATPase H+ transporting V1 subunit A [Source:HGNC Symbol%3BAcc:HGNC:851]
ENSG00000096093	19.89	19.71	20.33	20.00	17.99	19.77	0.064800147086159	5.57145253736811	0.357034089807539	0.729731051035984	6:52362122-52529886:+	EFHC1	12;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005930,cellular_component axoneme;GO:0008022,molecular_function protein C-terminus binding;GO:0021795,biological_process cerebral cortex cell migration;GO:0043025,cellular_component neuronal cell body;GO:0072686,cellular_component mitotic spindle	NA	EF-hand domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16406]
ENSG00000284024	7.17	5.21	5.44	5.67	5.04	5.52	0.157711869456785	2.66161525487715	0.357045049659899	0.729731051035984	10:14838165-14844727:+	AC069544.2	NA	NA	NA
ENSG00000106125	0.90	1.09	0.84	1.25	0.87	1.21	-0.236404918434561	1.31209619181492	0.357174414458688	0.729731051035984	7:30771416-30892387:+	MINDY4	5;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	MINDY lysine 48 deubiquitinase 4 [Source:HGNC Symbol%3BAcc:HGNC:21916]
ENSG00000154640	43.66	45.31	42.02	47.81	43.39	47.12	-0.0696361231251208	5.32280066369317	0.357213726107053	0.729731051035984	21:17593652-17612947:-	BTG3	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0008285,biological_process negative regulation of cell proliferation;GO:0045930,biological_process negative regulation of mitotic cell cycle	TOB; protein Tob/BTG; K14443	BTG anti-proliferation factor 3 [Source:HGNC Symbol%3BAcc:HGNC:1132]
ENSG00000157450	12.92	13.30	14.13	12.94	12.62	13.30	0.0658148422899668	5.3531771831913	0.357230667141981	0.729731051035984	15:58865174-59097419:+	RNF111	26;GO:0000209,biological_process protein polyubiquitination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0016567,biological_process protein ubiquitination;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030579,biological_process ubiquitin-dependent SMAD protein catabolic process;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032184,molecular_function SUMO polymer binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070911,biological_process global genome nucleotide-excision repair	NA	ring finger protein 111 [Source:HGNC Symbol%3BAcc:HGNC:17384]
ENSG00000132612	9.97	9.48	8.70	10.97	10.24	9.33	-0.104532465813886	3.69864392290385	0.357252525348076	0.729731051035984	16:69311355-69326939:+	VPS4A	62;GO:0000166,molecular_function nucleotide binding;GO:0000815,cellular_component ESCRT III complex;GO:0000916,biological_process actomyosin contractile ring contraction;GO:0000920,biological_process cell separation after cytokinesis;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005774,cellular_component vacuolar membrane;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006622,biological_process protein targeting to lysosome;GO:0006810,biological_process transport;GO:0006900,biological_process membrane budding;GO:0006997,biological_process nucleus organization;GO:0006998,biological_process nuclear envelope organization;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008022,molecular_function protein C-terminus binding;GO:0009838,biological_process abscission;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0019058,biological_process viral life cycle;GO:0019076,biological_process viral release from host cell;GO:0019904,molecular_function protein domain specific binding;GO:0030496,cellular_component midbody;GO:0031902,cellular_component late endosome membrane;GO:0032367,biological_process intracellular cholesterol transport;GO:0032466,biological_process negative regulation of cytokinesis;GO:0032880,biological_process regulation of protein localization;GO:0034058,biological_process endosomal vesicle fusion;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042623,molecular_function ATPase activity, coupled;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0044878,biological_process mitotic cytokinesis checkpoint;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0061640,biological_process cytoskeleton-dependent cytokinesis;GO:0061738,biological_process late endosomal microautophagy;GO:0070062,cellular_component extracellular exosome;GO:0072319,biological_process vesicle uncoating;GO:0090543,cellular_component Flemming body;GO:0090611,biological_process ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:1902188,biological_process positive regulation of viral release from host cell;GO:1903076,biological_process regulation of protein localization to plasma membrane;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903774,biological_process positive regulation of viral budding via host ESCRT complex;GO:1903902,biological_process positive regulation of viral life cycle;GO:1904896,biological_process ESCRT complex disassembly;GO:1904903,biological_process ESCRT III complex disassembly	VPS4; vacuolar protein-sorting-associated protein 4; K12196	vacuolar protein sorting 4 homolog A [Source:HGNC Symbol%3BAcc:HGNC:13488]
ENSG00000106638	36.55	37.17	36.96	37.46	34.37	35.09	0.0610622477099413	5.83658513098921	0.357381132386362	0.729873642038814	7:73568931-73578791:-	TBL2	9;GO:0003723,molecular_function RNA binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0019901,molecular_function protein kinase binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031369,molecular_function translation initiation factor binding;GO:0042149,biological_process cellular response to glucose starvation;GO:0051219,molecular_function phosphoprotein binding;GO:0071456,biological_process cellular response to hypoxia	NA	transducin beta like 2 [Source:HGNC Symbol%3BAcc:HGNC:11586]
ENSG00000101220	35.85	35.38	32.30	32.73	35.70	29.56	0.0911993278030706	4.33499010121167	0.357534912720168	0.7300675886816	20:3753507-3768387:-	C20orf27	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	chromosome 20 open reading frame 27 [Source:HGNC Symbol%3BAcc:HGNC:15873]
ENSG00000136932	9.58	7.67	8.06	9.18	8.78	9.54	-0.0997535181679658	3.84396045679784	0.357848798087036	0.730535043541329	9:97904488-97922570:-	TRMO	6;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016430,molecular_function tRNA (adenine-N6-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	tRNA methyltransferase O [Source:HGNC Symbol%3BAcc:HGNC:30967]
ENSG00000254087	21.75	24.02	22.81	21.79	21.92	22.11	0.0664041406102207	5.1098287827472	0.358030284586261	0.730535043541329	8:55879812-56014168:+	LYN	134;GO:0000166,molecular_function nucleotide binding;GO:0001782,biological_process B cell homeostasis;GO:0001817,biological_process regulation of cytokine production;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002431,biological_process Fc receptor mediated stimulatory signaling pathway;GO:0002513,biological_process tolerance induction to self antigen;GO:0002553,biological_process histamine secretion by mast cell;GO:0002576,biological_process platelet degranulation;GO:0002762,biological_process negative regulation of myeloid leukocyte differentiation;GO:0002768,biological_process immune response-regulating cell surface receptor signaling pathway;GO:0002774,biological_process Fc receptor mediated inhibitory signaling pathway;GO:0002902,biological_process regulation of B cell apoptotic process;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0004716,molecular_function receptor signaling protein tyrosine kinase activity;GO:0005102,molecular_function receptor binding;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006991,biological_process response to sterol depletion;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007417,biological_process central nervous system development;GO:0007596,biological_process blood coagulation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009636,biological_process response to toxic substance;GO:0009725,biological_process response to hormone;GO:0009743,biological_process response to carbohydrate;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014003,biological_process oligodendrocyte development;GO:0014069,cellular_component postsynaptic density;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017124,molecular_function SH3 domain binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030061,cellular_component mitochondrial crista;GO:0030097,biological_process hemopoiesis;GO:0030168,biological_process platelet activation;GO:0030218,biological_process erythrocyte differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030889,biological_process negative regulation of B cell proliferation;GO:0031175,biological_process neuron projection development;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031295,biological_process T cell costimulation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0031966,cellular_component mitochondrial membrane;GO:0032403,molecular_function protein complex binding;GO:0032868,biological_process response to insulin;GO:0033003,biological_process regulation of mast cell activation;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0034136,biological_process negative regulation of toll-like receptor 2 signaling pathway;GO:0034144,biological_process negative regulation of toll-like receptor 4 signaling pathway;GO:0034605,biological_process cellular response to heat;GO:0034666,cellular_component integrin alpha2-beta1 complex;GO:0035556,biological_process intracellular signal transduction;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042493,biological_process response to drug;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042629,cellular_component mast cell granule;GO:0043015,molecular_function gamma-tubulin binding;GO:0043200,biological_process response to amino acid;GO:0043208,molecular_function glycosphingolipid binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043304,biological_process regulation of mast cell degranulation;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043434,biological_process response to peptide hormone;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0044325,molecular_function ion channel binding;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045646,biological_process regulation of erythrocyte differentiation;GO:0046777,biological_process protein autophosphorylation;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048678,biological_process response to axon injury;GO:0050663,biological_process cytokine secretion;GO:0050707,biological_process regulation of cytokine secretion;GO:0050727,biological_process regulation of inflammatory response;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050777,biological_process negative regulation of immune response;GO:0050853,biological_process B cell receptor signaling pathway;GO:0050855,biological_process regulation of B cell receptor signaling pathway;GO:0050861,biological_process positive regulation of B cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0051219,molecular_function phosphoprotein binding;GO:0051272,biological_process positive regulation of cellular component movement;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0060369,biological_process positive regulation of Fc receptor mediated stimulatory signaling pathway;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070304,biological_process positive regulation of stress-activated protein kinase signaling cascade;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070447,biological_process positive regulation of oligodendrocyte progenitor proliferation;GO:0070667,biological_process negative regulation of mast cell proliferation;GO:0070668,biological_process positive regulation of mast cell proliferation;GO:0071300,biological_process cellular response to retinoic acid;GO:0090025,biological_process regulation of monocyte chemotaxis;GO:0090330,biological_process regulation of platelet aggregation;GO:0097028,biological_process dendritic cell differentiation;GO:1902532,biological_process negative regulation of intracellular signal transduction;GO:1902961,biological_process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:2000670,biological_process positive regulation of dendritic cell apoptotic process	LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]; K05854	LYN proto-oncogene%2C Src family tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:6735]
ENSG00000146574	26.42	23.79	29.62	30.50	27.85	26.94	-0.0784118434257963	5.32362682109458	0.358039164234947	0.730535043541329	7:6794133-6826770:-	CCZ1B	8;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016235,cellular_component aggresome;GO:0031982,cellular_component vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	CCZ1 homolog B%2C vacuolar protein trafficking and biogenesis associated [Source:HGNC Symbol%3BAcc:HGNC:21717]
ENSG00000174231	65.83	71.82	66.50	71.61	74.65	68.25	-0.0600786062871725	8.96349487470039	0.358057623589412	0.730535043541329	17:1650628-1684882:-	PRPF8	27;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000386,molecular_function second spliceosomal transesterification activity;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0017070,molecular_function U6 snRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0030619,molecular_function U1 snRNA binding;GO:0030620,molecular_function U2 snRNA binding;GO:0030623,molecular_function U5 snRNA binding;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0097157,molecular_function pre-mRNA intronic binding	PRPF8, PRP8; pre-mRNA-processing factor 8; K12856	pre-mRNA processing factor 8 [Source:HGNC Symbol%3BAcc:HGNC:17340]
ENSG00000103723	0.39	0.28	0.28	0.51	0.42	0.29	-0.312875491256524	0.47830486913046	0.358135227343354	0.730535043541329	15:82659280-82709914:-	AP3B2	17;GO:0005215,molecular_function transporter activity;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0008089,biological_process anterograde axonal transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030137,cellular_component COPI-coated vesicle;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:1904115,cellular_component axon cytoplasm	AP3B; AP-3 complex subunit beta; K12397	adaptor related protein complex 3 beta 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:567]
ENSG00000119723	9.99	10.98	11.34	12.15	10.53	12.07	-0.0972404642572525	4.15951122918986	0.358224078281365	0.730535043541329	14:73949925-73963670:+	COQ6	12;GO:0004497,molecular_function monooxygenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016709,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0042995,cellular_component cell projection;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	COQ6; ubiquinone biosynthesis monooxygenase Coq6 [EC:1.14.13.-]; K06126	coenzyme Q6%2C monooxygenase [Source:HGNC Symbol%3BAcc:HGNC:20233]
ENSG00000145287	315.87	283.93	321.92	305.56	272.15	309.40	0.0685665127667819	6.70454146041285	0.358234147889214	0.730535043541329	4:83090047-83137075:-	PLAC8	11;GO:0003682,molecular_function chromatin binding;GO:0005576,cellular_component extracellular region;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009409,biological_process response to cold;GO:0035578,cellular_component azurophil granule lumen;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0042742,biological_process defense response to bacterium;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050873,biological_process brown fat cell differentiation	NA	placenta specific 8 [Source:HGNC Symbol%3BAcc:HGNC:19254]
ENSG00000198046	6.00	5.22	5.36	5.87	5.87	6.29	-0.104142432952332	3.53608330324888	0.358248504910406	0.730535043541329	19:56439324-56478065:-	ZNF667	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 667 [Source:HGNC Symbol%3BAcc:HGNC:28854]
ENSG00000165288	6.10	6.13	5.73	5.64	6.00	5.59	0.0707165168933328	4.99360667254565	0.358293510439025	0.730535043541329	X:80670853-80809688:-	BRWD3	4;GO:0005634,cellular_component nucleus;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape	NA	bromodomain and WD repeat domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:17342]
ENSG00000137509	123.09	123.42	121.80	120.95	115.28	121.24	0.0546630406037232	7.60032051731446	0.358375093721657	0.73058138255328	11:82823501-82970584:-	PRCP	24;GO:0002155,biological_process regulation of thyroid hormone mediated signaling pathway;GO:0002353,biological_process plasma kallikrein-kinin cascade;GO:0003085,biological_process negative regulation of systemic arterial blood pressure;GO:0004180,molecular_function carboxypeptidase activity;GO:0004185,molecular_function serine-type carboxypeptidase activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008239,molecular_function dipeptidyl-peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0035577,cellular_component azurophil granule membrane;GO:0042593,biological_process glucose homeostasis;GO:0043312,biological_process neutrophil degranulation;GO:0043535,biological_process regulation of blood vessel endothelial cell migration;GO:0045178,cellular_component basal part of cell;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0070062,cellular_component extracellular exosome;GO:0097009,biological_process energy homeostasis;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	PRCP; lysosomal Pro-X carboxypeptidase [EC:3.4.16.2]; K01285	prolylcarboxypeptidase [Source:HGNC Symbol%3BAcc:HGNC:9344]
ENSG00000135390	157.30	164.26	149.68	156.55	147.73	150.70	0.0608609989290356	6.52131528632419	0.35848428771745	0.730645794403839	12:53632725-53677408:-	ATP5G2	21;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005215,molecular_function transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008289,molecular_function lipid binding;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0033177,cellular_component proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism	ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c; K02128	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit C2 (subunit 9) [Source:HGNC Symbol%3BAcc:HGNC:842]
ENSG00000062485	53.81	61.46	54.89	54.53	58.31	50.33	0.0700471360579988	6.31577127340939	0.35852441260886	0.730645794403839	12:56271698-56300392:-	CS	13;GO:0003723,molecular_function RNA binding;GO:0004108,molecular_function citrate (Si)-synthase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006101,biological_process citrate metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0046912,molecular_function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer;GO:0070062,cellular_component extracellular exosome	CS, gltA; citrate synthase [EC:2.3.3.1]; K01647	citrate synthase [Source:HGNC Symbol%3BAcc:HGNC:2422]
ENSG00000028116	30.95	28.86	28.40	30.35	30.84	31.75	-0.0624085741448556	5.58790553460289	0.358727628543828	0.730926635385192	2:57907650-58159920:+	VRK2	27;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006468,biological_process protein phosphorylation;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0031966,cellular_component mitochondrial membrane;GO:0034599,biological_process cellular response to oxidative stress;GO:0043234,cellular_component protein complex;GO:0043408,biological_process regulation of MAPK cascade;GO:0046777,biological_process protein autophosphorylation;GO:2000659,biological_process regulation of interleukin-1-mediated signaling pathway	NA	vaccinia related kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:12719]
ENSG00000196636	47.08	42.00	45.98	36.79	47.19	43.23	0.102988753003855	4.16080988358132	0.358779987867717	0.730926635385192	7:97116589-97181763:+	SDHAF3	7;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0006105,biological_process succinate metabolic process;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006979,biological_process response to oxidative stress;GO:0034553,biological_process mitochondrial respiratory chain complex II assembly	NA	succinate dehydrogenase complex assembly factor 3 [Source:HGNC Symbol%3BAcc:HGNC:21752]
ENSG00000168016	2.89	2.48	2.69	3.08	2.53	3.05	-0.0883266598263204	4.6455661450083	0.358982581210232	0.731219360118578	3:36826819-36945057:-	TRANK1	NA	NA	tetratricopeptide repeat and ankyrin repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29011]
ENSG00000196290	23.86	22.24	22.10	24.23	26.06	22.40	-0.0773124937926704	4.8246666115124	0.359179669163861	0.731500776592453	2:200889326-200903930:+	NIF3L1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0008134,molecular_function transcription factor binding;GO:0030182,biological_process neuron differentiation;GO:0042802,molecular_function identical protein binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	NGG1 interacting factor 3 like 1 [Source:HGNC Symbol%3BAcc:HGNC:13390]
ENSG00000029153	13.97	13.98	14.52	15.55	14.89	14.60	-0.0713337206440225	4.8324564968291	0.359407483257696	0.731844666941892	12:27332853-27425289:+	ARNTL2	18;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007623,biological_process circadian rhythm;GO:0009649,biological_process entrainment of circadian clock;GO:0042753,biological_process positive regulation of circadian rhythm;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0070888,molecular_function E-box binding	NA	aryl hydrocarbon receptor nuclear translocator like 2 [Source:HGNC Symbol%3BAcc:HGNC:18984]
ENSG00000101166	56.74	54.40	59.01	63.23	55.23	62.14	-0.0723941410844126	5.10488580662656	0.359556095574044	0.732027196057176	20:59033144-59042909:-	PRELID3B	4;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0015914,biological_process phospholipid transport;GO:1990050,molecular_function phosphatidic acid transporter activity	NA	PRELI domain containing 3B [Source:HGNC Symbol%3BAcc:HGNC:15892]
ENSG00000010219	7.29	9.46	9.58	8.97	7.33	8.22	0.109024556524775	4.17629550745518	0.359645422202788	0.732088984224862	12:4562203-4615302:+	DYRK4	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	NA	dual specificity tyrosine phosphorylation regulated kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:3095]
ENSG00000122481	14.94	14.93	16.57	18.23	15.49	16.61	-0.101995930523852	3.73245817117382	0.359706859839444	0.732093991012792	1:95234154-95247225:+	RWDD3	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0033235,biological_process positive regulation of protein sumoylation;GO:1902073,biological_process positive regulation of hypoxia-inducible factor-1alpha signaling pathway	NA	RWD domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:21393]
ENSG00000138434	32.30	32.22	29.00	29.66	29.10	31.49	0.0621605035407706	6.89635127914543	0.359804139469976	0.732171931678821	2:181891832-181930738:+	SSFA2	7;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0051015,molecular_function actin filament binding	NA	sperm specific antigen 2 [Source:HGNC Symbol%3BAcc:HGNC:11319]
ENSG00000127920	1462.18	1523.38	1459.59	1414.02	1439.97	1464.80	0.0530243424190052	8.32292869829842	0.360140659338832	0.732629279773526	7:93921698-93928610:+	GNG11	9;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0071377,biological_process cellular response to glucagon stimulus	GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; K04546	G protein subunit gamma 11 [Source:HGNC Symbol%3BAcc:HGNC:4403]
ENSG00000204390	0.55	0.89	0.69	0.58	0.83	1.24	-0.33606601085073	0.752515324905664	0.360167890794169	0.732629279773526	6:31809618-31815065:-	HSPA1L	19;GO:0000166,molecular_function nucleotide binding;GO:0002199,cellular_component zona pellucida receptor complex;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006986,biological_process response to unfolded protein;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0008180,cellular_component COP9 signalosome;GO:0031072,molecular_function heat shock protein binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042026,biological_process protein refolding;GO:0044297,cellular_component cell body;GO:0051082,molecular_function unfolded protein binding;GO:0072562,cellular_component blood microparticle;GO:1900034,biological_process regulation of cellular response to heat;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	HSPA1s; heat shock 70kDa protein 1/2/6/8; K03283	heat shock protein family A (Hsp70) member 1 like [Source:HGNC Symbol%3BAcc:HGNC:5234]
ENSG00000204262	0.20	0.34	0.29	0.42	0.22	0.41	-0.329621506185973	0.639902569678999	0.36023651944035	0.732629279773526	2:189031895-189179879:-	COL5A2	20;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0003674,molecular_function molecular_function;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005588,cellular_component collagen type V trimer;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0043588,biological_process skin development;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0048592,biological_process eye morphogenesis;GO:0071230,biological_process cellular response to amino acid stimulus;GO:1903225,biological_process negative regulation of endodermal cell differentiation	COL1A; collagen, type I, alpha; K06236	collagen type V alpha 2 chain [Source:HGNC Symbol%3BAcc:HGNC:2210]
ENSG00000145216	17.70	17.04	19.86	19.96	18.31	19.79	-0.0734266176404916	5.10663486905813	0.360264974118876	0.732629279773526	4:53377642-53460861:+	FIP1L1	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0031124,biological_process mRNA 3'-end processing;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation	FIP1L1, FIP1; pre-mRNA 3'-end-processing factor FIP1; K14405	factor interacting with PAPOLA and CPSF1 [Source:HGNC Symbol%3BAcc:HGNC:19124]
ENSG00000103249	31.92	34.57	33.71	32.01	32.64	32.24	0.0590785304763924	6.53296836391501	0.360354917316612	0.732652227101573	16:1444933-1475580:-	CLCN7	19;GO:0000166,molecular_function nucleotide binding;GO:0005216,molecular_function ion channel activity;GO:0005247,molecular_function voltage-gated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005524,molecular_function ATP binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0009268,biological_process response to pH;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034220,biological_process ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:1902476,biological_process chloride transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport	NA	chloride voltage-gated channel 7 [Source:HGNC Symbol%3BAcc:HGNC:2025]
ENSG00000168077	6.84	8.02	6.06	7.70	7.68	7.27	-0.113649318755894	3.75764167850951	0.360408778425178	0.732652227101573	8:27633867-27676776:+	SCARA3	12;GO:0000139,cellular_component Golgi membrane;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0005581,cellular_component collagen trimer;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006979,biological_process response to oxidative stress;GO:0009650,biological_process UV protection;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	scavenger receptor class A member 3 [Source:HGNC Symbol%3BAcc:HGNC:19000]
ENSG00000180479	3.21	4.03	3.69	3.86	3.91	4.22	-0.133980986989579	3.05125841495697	0.360496033038184	0.732652227101573	19:37554781-37594790:-	ZNF571	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005198,molecular_function structural molecule activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0019028,cellular_component viral capsid;GO:0019058,biological_process viral life cycle;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 571 [Source:HGNC Symbol%3BAcc:HGNC:25000]
ENSG00000169359	21.23	19.67	20.65	20.05	18.33	20.71	0.0725997176862756	5.05784771086112	0.360512350208363	0.732652227101573	3:155821023-155854429:-	SLC33A1	14;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008521,molecular_function acetyl-CoA transporter activity;GO:0015295,molecular_function solute:proton symporter activity;GO:0015876,biological_process acetyl-CoA transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030509,biological_process BMP signaling pathway;GO:0055085,biological_process transmembrane transport;GO:0060395,biological_process SMAD protein signal transduction	ACATN, SLC33A1; MFS transporter, PAT family, solute carrier family 33 (acetyl-CoA transportor), member 1 [EC:2.3.1.-]; K03372	solute carrier family 33 member 1 [Source:HGNC Symbol%3BAcc:HGNC:95]
ENSG00000156697	13.07	11.24	10.35	12.26	11.15	13.97	-0.0962025957157475	4.82740541650592	0.360590838945295	0.732691779968562	X:129906120-129929761:+	UTP14A	10;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0030490,biological_process maturation of SSU-rRNA;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis	UTP14; U3 small nucleolar RNA-associated protein 14; K14567	UTP14A%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:10665]
ENSG00000164880	23.71	25.57	23.76	25.50	25.80	25.30	-0.0579307510102673	7.36485531764821	0.360992487190916	0.733387846726814	7:1470276-1504367:-	INTS1	9;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016180,biological_process snRNA processing;GO:0031965,cellular_component nuclear membrane;GO:0032039,cellular_component integrator complex;GO:0034474,biological_process U2 snRNA 3'-end processing;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:24555]
ENSG00000221988	1.76	2.69	4.06	3.81	3.94	2.66	-0.275754037666678	1.61644514499849	0.36120927120307	0.733708179257684	6:32153440-32163680:+	PPT2	12;GO:0005764,cellular_component lysosome;GO:0008474,molecular_function palmitoyl-(protein) hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016790,molecular_function thiolester hydrolase activity;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0070062,cellular_component extracellular exosome;GO:0098599,molecular_function palmitoyl hydrolase activity;GO:0098734,biological_process macromolecule depalmitoylation	PPT; palmitoyl-protein thioesterase [EC:3.1.2.22]; K01074	palmitoyl-protein thioesterase 2 [Source:HGNC Symbol%3BAcc:HGNC:9326]
ENSG00000103942	27.40	24.69	26.99	24.54	24.86	26.43	0.0762522925237126	4.81183284524907	0.361519796339014	0.734127838343148	15:82836945-82986153:-	HOMER2	28;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007216,biological_process G-protein coupled glutamate receptor signaling pathway;GO:0007605,biological_process sensory perception of sound;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030160,molecular_function GKAP/Homer scaffold activity;GO:0030425,cellular_component dendrite;GO:0032420,cellular_component stereocilium;GO:0032426,cellular_component stereocilium tip;GO:0035254,molecular_function glutamate receptor binding;GO:0035256,molecular_function G-protein coupled glutamate receptor binding;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0045177,cellular_component apical part of cell;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046982,molecular_function protein heterodimerization activity;GO:0048148,biological_process behavioral response to cocaine;GO:0048875,biological_process chemical homeostasis within a tissue	HOMER; homer; K15010	homer scaffolding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17513]
ENSG00000162419	4.60	4.50	5.05	5.79	5.07	4.75	-0.124059825946008	3.12090323726631	0.361590073728936	0.734127838343148	1:28668731-28719353:+	GMEB1	15;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	glucocorticoid modulatory element binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4370]
ENSG00000178761	22.75	18.30	25.17	22.42	18.56	20.84	0.120855320526663	3.83397243607942	0.361655951896855	0.734127838343148	15:74899986-74907121:-	FAM219B	NA	NA	family with sequence similarity 219 member B [Source:HGNC Symbol%3BAcc:HGNC:24695]
ENSG00000133895	22.09	26.47	22.70	26.54	24.83	24.20	-0.0785537774402629	5.49989050808104	0.361660327163545	0.734127838343148	11:64803509-64811294:-	MEN1	61;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000278,biological_process mitotic cell cycle;GO:0000400,molecular_function four-way junction DNA binding;GO:0000403,molecular_function Y-form DNA binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002076,biological_process osteoblast development;GO:0003309,biological_process type B pancreatic cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007420,biological_process brain development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009411,biological_process response to UV;GO:0010332,biological_process response to gamma radiation;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030674,molecular_function protein binding, bridging;GO:0032092,biological_process positive regulation of protein binding;GO:0032154,cellular_component cleavage furrow;GO:0032925,biological_process regulation of activin receptor signaling pathway;GO:0034968,biological_process histone lysine methylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0043234,cellular_component protein complex;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043687,biological_process post-translational protein modification;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044267,biological_process cellular protein metabolic process;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786,biological_process negative regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046697,biological_process decidualization;GO:0047485,molecular_function protein N-terminus binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051974,biological_process negative regulation of telomerase activity;GO:0061469,biological_process regulation of type B pancreatic cell proliferation;GO:0070412,molecular_function R-SMAD binding;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071559,biological_process response to transforming growth factor beta;GO:1902807,biological_process negative regulation of cell cycle G1/S phase transition;GO:1904837,biological_process beta-catenin-TCF complex assembly	MEN1, MNN1; menin; K14970	menin 1 [Source:HGNC Symbol%3BAcc:HGNC:7010]
ENSG00000068308	44.24	39.72	46.66	42.40	42.95	40.60	0.0677718130350376	6.19978033422739	0.361711581350737	0.734127838343148	X:48922027-48958386:-	OTUD5	15;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032496,biological_process response to lipopolysaccharide;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0101005,molecular_function ubiquitinyl hydrolase activity;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	OTUD5, DUBA; OTU domain-containing protein 5 [EC:3.4.19.12]; K12655	OTU deubiquitinase 5 [Source:HGNC Symbol%3BAcc:HGNC:25402]
ENSG00000041353	9.41	12.50	11.20	8.37	11.81	9.95	0.138512478620232	3.16389692447069	0.361944824134563	0.734409653282365	18:54717859-54895516:+	RAB27B	25;GO:0000166,molecular_function nucleotide binding;GO:0002576,biological_process platelet degranulation;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017157,biological_process regulation of exocytosis;GO:0019003,molecular_function GDP binding;GO:0019904,molecular_function protein domain specific binding;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030141,cellular_component secretory granule;GO:0030667,cellular_component secretory granule membrane;GO:0031088,cellular_component platelet dense granule membrane;GO:0031489,molecular_function myosin V binding;GO:0032402,biological_process melanosome transport;GO:0032585,cellular_component multivesicular body membrane;GO:0042470,cellular_component melanosome;GO:0042589,cellular_component zymogen granule membrane;GO:0045921,biological_process positive regulation of exocytosis;GO:0070062,cellular_component extracellular exosome;GO:0071985,biological_process multivesicular body sorting pathway	RAB27B; Ras-related protein Rab-27B; K07886	RAB27B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9767]
ENSG00000140983	40.17	36.10	42.08	44.11	40.47	40.52	-0.0654390578536051	6.36190961364179	0.361968763295054	0.734409653282365	16:668085-674174:+	RHOT2	21;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007005,biological_process mitochondrion organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019725,biological_process cellular homeostasis;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0046872,molecular_function metal ion binding;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome;GO:0097345,biological_process mitochondrial outer membrane permeabilization	RHOT2, ARHT2; mitochondrial Rho GTPase 2 [EC:3.6.5.-]; K07871	ras homolog family member T2 [Source:HGNC Symbol%3BAcc:HGNC:21169]
ENSG00000151806	17.35	16.57	15.62	18.06	16.32	18.11	-0.0722868735869828	5.10110751683418	0.362281159975355	0.734543050149879	4:44678426-44700926:+	GUF1	11;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0043022,molecular_function ribosome binding;GO:0045727,biological_process positive regulation of translation	NA	GUF1 homolog%2C GTPase [Source:HGNC Symbol%3BAcc:HGNC:25799]
ENSG00000132680	24.34	23.32	25.56	25.21	21.92	23.27	0.0706207466474076	5.50514610159858	0.362303226273117	0.734543050149879	1:155913042-155934400:-	KIAA0907	3;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	KIAA0907 [Source:HGNC Symbol%3BAcc:HGNC:29145]
ENSG00000172590	67.51	58.79	75.22	75.97	68.41	71.87	-0.0832617276884361	4.84099608224708	0.362313601269482	0.734543050149879	14:22829878-22835037:+	MRPL52	10;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L52 [Source:HGNC Symbol%3BAcc:HGNC:16655]
ENSG00000122490	10.73	10.73	11.32	10.38	9.59	10.81	0.101744866658278	3.50939696604876	0.362330827483912	0.734543050149879	18:79902419-79951664:-	PQLC1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	PQ loop repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26188]
ENSG00000010256	111.58	120.88	111.26	124.40	115.56	120.98	-0.0599014399743721	7.45780685637483	0.362387523257198	0.734543050149879	3:48599001-48610976:-	UQCRC1	23;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0005829,cellular_component cytosol;GO:0006119,biological_process oxidative phosphorylation;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0008270,molecular_function zinc ion binding;GO:0009060,biological_process aerobic respiration;GO:0014823,biological_process response to activity;GO:0016020,cellular_component membrane;GO:0016485,biological_process protein processing;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0043209,cellular_component myelin sheath;GO:0043279,biological_process response to alkaloid;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	QCR1, UQCRC1; ubiquinol-cytochrome c reductase core subunit 1; K00414	ubiquinol-cytochrome c reductase core protein I [Source:HGNC Symbol%3BAcc:HGNC:12585]
ENSG00000198478	4.62	3.57	2.98	2.80	2.84	3.29	0.338951253495325	0.29704271709008	0.362389562484319	0.734543050149879	6:79631282-79703659:+	SH3BGRL2	6;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0017124,molecular_function SH3 domain binding;GO:0031965,cellular_component nuclear membrane;GO:0070062,cellular_component extracellular exosome	NA	SH3 domain binding glutamate rich protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:15567]
ENSG00000168904	10.43	9.29	11.32	9.53	7.98	11.13	0.131519437875489	3.51694076396954	0.36249592614119	0.734580321677698	15:99251361-99390729:+	LRRC28	1;GO:0007165,biological_process signal transduction	NA	leucine rich repeat containing 28 [Source:HGNC Symbol%3BAcc:HGNC:28355]
ENSG00000186017	4.03	3.30	3.54	3.38	3.30	3.17	0.165638431112027	2.25138638725104	0.362583815292712	0.734580321677698	19:36445118-36489902:-	ZNF566	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 566 [Source:HGNC Symbol%3BAcc:HGNC:25919]
ENSG00000121766	41.33	39.45	39.41	41.58	35.09	38.63	0.072362376744779	5.30543487952355	0.362694779115087	0.734580321677698	1:31296981-31364953:+	ZCCHC17	9;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008270,molecular_function zinc ion binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 17 [Source:HGNC Symbol%3BAcc:HGNC:30246]
ENSG00000163395	120.73	137.66	121.61	127.06	150.15	126.14	-0.0742714509472277	10.507136034632	0.362701588838447	0.734580321677698	1:201190824-201228952:+	IGFN1	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0030018,cellular_component Z disc	NA	immunoglobulin-like and fibronectin type III domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24607]
ENSG00000187555	38.04	35.32	37.05	38.82	36.90	40.29	-0.0586041287203025	6.9977590836643	0.362703842065787	0.734580321677698	16:8892093-8964514:-	USP7	34;GO:0002039,molecular_function p53 binding;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007275,biological_process multicellular organism development;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010216,biological_process maintenance of DNA methylation;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0035520,biological_process monoubiquitinated protein deubiquitination;GO:0035616,biological_process histone H2B conserved C-terminal lysine deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0050821,biological_process protein stabilization;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:1904353,biological_process regulation of telomere capping	USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]; K11838	ubiquitin specific peptidase 7 [Source:HGNC Symbol%3BAcc:HGNC:12630]
ENSG00000184162	19.05	23.81	22.38	23.54	21.76	25.37	-0.113773542156418	3.73577895135189	0.363128073360523	0.735319539090404	19:19201415-19203424:-	NR2C2AP	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0070062,cellular_component extracellular exosome	NA	nuclear receptor 2C2 associated protein [Source:HGNC Symbol%3BAcc:HGNC:30763]
ENSG00000105676	9.11	11.51	10.17	9.94	12.48	10.85	-0.107024272655539	4.31951963806227	0.363337631097894	0.73562388106641	19:19033574-19060311:+	ARMC6	2;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005829,cellular_component cytosol	NA	armadillo repeat containing 6 [Source:HGNC Symbol%3BAcc:HGNC:25049]
ENSG00000196357	2.75	2.42	2.96	3.24	3.38	2.65	-0.163234437683384	2.28151518831902	0.363423416943124	0.735650147198275	19:36182059-36246257:-	ZNF565	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 565 [Source:HGNC Symbol%3BAcc:HGNC:26726]
ENSG00000148834	106.67	104.53	101.42	121.96	99.48	109.41	-0.0702575658177634	6.28483010648443	0.363479075377541	0.735650147198275	10:104235355-104267459:+	GSTO1	25;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0008152,biological_process metabolic process;GO:0009407,biological_process toxin catabolic process;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014810,biological_process positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0016491,molecular_function oxidoreductase activity;GO:0016740,molecular_function transferase activity;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0032259,biological_process methylation;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042178,biological_process xenobiotic catabolic process;GO:0045174,molecular_function glutathione dehydrogenase (ascorbate) activity;GO:0050610,molecular_function methylarsonate reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060315,biological_process negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0060316,biological_process positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0070062,cellular_component extracellular exosome;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase omega 1 [Source:HGNC Symbol%3BAcc:HGNC:13312]
ENSG00000176024	4.11	3.15	2.88	2.82	3.40	2.97	0.16294565272826	2.68250327341297	0.363528397882399	0.735650147198275	19:51927146-51948759:+	ZNF613	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 613 [Source:HGNC Symbol%3BAcc:HGNC:25827]
ENSG00000168275	28.03	25.72	29.34	30.74	27.52	31.15	-0.0890617886995751	4.09462321522883	0.36363653971574	0.735749041155905	1:234373455-234384049:+	COA6	8;GO:0003723,molecular_function RNA binding;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005886,cellular_component plasma membrane;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0042774,biological_process plasma membrane ATP synthesis coupled electron transport	NA	cytochrome c oxidase assembly factor 6 [Source:HGNC Symbol%3BAcc:HGNC:18025]
ENSG00000154710	9.34	9.92	8.55	10.27	7.73	7.82	0.115203462387429	3.86601726292363	0.363949022341628	0.735845794822621	7:66682163-66811464:+	RABGEF1	20;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0016567,biological_process protein ubiquitination;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0031901,cellular_component early endosome membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization	NA	RAB guanine nucleotide exchange factor 1 [Source:HGNC Symbol%3BAcc:HGNC:17676]
ENSG00000153814	5.73	7.34	7.64	7.20	9.43	6.69	-0.16365483458711	2.79129921420188	0.364007905540085	0.735845794822621	7:27830572-28180743:-	JAZF1	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006629,biological_process lipid metabolic process;GO:0017053,cellular_component transcriptional repressor complex;GO:0046872,molecular_function metal ion binding	NA	JAZF zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:28917]
ENSG00000172239	132.80	126.49	131.73	135.94	135.27	138.09	-0.0535472562035157	7.584858855257	0.364011351460137	0.735845794822621	5:43526266-43557758:-	PAIP1	10;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0008494,molecular_function translation activator activity;GO:0045727,biological_process positive regulation of translation;GO:0048255,biological_process mRNA stabilization	PAIP1; polyadenylate-binding protein-interacting protein 1; K14322	poly(A) binding protein interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16945]
ENSG00000031691	11.07	13.43	14.19	11.92	12.92	10.85	0.125151828935043	3.33434011933556	0.364105522958319	0.735845794822621	6:49463377-49493107:+	CENPQ	10;GO:0000775,cellular_component chromosome, centromeric region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0015629,cellular_component actin cytoskeleton;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0051310,biological_process metaphase plate congression;GO:1905342,biological_process positive regulation of protein localization to kinetochore	NA	centromere protein Q [Source:HGNC Symbol%3BAcc:HGNC:21347]
ENSG00000100162	19.66	23.86	17.59	20.96	21.57	23.83	-0.119938475334182	3.823397240018	0.364177283309504	0.735845794822621	22:41938720-41947164:-	CENPM	10;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0034080,biological_process CENP-A containing nucleosome assembly	NA	centromere protein M [Source:HGNC Symbol%3BAcc:HGNC:18352]
ENSG00000102974	29.69	27.60	27.37	27.29	31.68	30.44	-0.0656488061182374	5.98866946163546	0.36418981574501	0.735845794822621	16:67562406-67639183:+	CTCF	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000775,cellular_component chromosome, centromeric region;GO:0000793,cellular_component condensed chromosome;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0006306,biological_process DNA methylation;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007059,biological_process chromosome segregation;GO:0008270,molecular_function zinc ion binding;GO:0010216,biological_process maintenance of DNA methylation;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016569,biological_process covalent chromatin modification;GO:0016584,biological_process nucleosome positioning;GO:0031060,biological_process regulation of histone methylation;GO:0035065,biological_process regulation of histone acetylation;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0040030,biological_process regulation of molecular function, epigenetic;GO:0043035,molecular_function chromatin insulator sequence binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0070602,biological_process regulation of centromeric sister chromatid cohesion;GO:0071459,biological_process protein localization to chromosome, centromeric region	NA	CCCTC-binding factor [Source:HGNC Symbol%3BAcc:HGNC:13723]
ENSG00000075239	125.80	136.18	115.98	116.26	124.89	123.02	0.064118474114804	7.38823281789756	0.364200278669264	0.735845794822621	11:108121515-108147776:+	ACAT1	35;GO:0001889,biological_process liver development;GO:0003824,molecular_function catalytic activity;GO:0003985,molecular_function acetyl-CoA C-acetyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006085,biological_process acetyl-CoA biosynthetic process;GO:0006550,biological_process isoleucine catabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0007420,biological_process brain development;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0009725,biological_process response to hormone;GO:0014070,biological_process response to organic cyclic compound;GO:0015936,biological_process coenzyme A metabolic process;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0016830,molecular_function carbon-carbon lyase activity;GO:0016885,molecular_function ligase activity, forming carbon-carbon bonds;GO:0019899,molecular_function enzyme binding;GO:0042594,biological_process response to starvation;GO:0042803,molecular_function protein homodimerization activity;GO:0046356,biological_process acetyl-CoA catabolic process;GO:0046872,molecular_function metal ion binding;GO:0046951,biological_process ketone body biosynthetic process;GO:0046952,biological_process ketone body catabolic process;GO:0050662,molecular_function coenzyme binding;GO:0051260,biological_process protein homooligomerization;GO:0060612,biological_process adipose tissue development;GO:0070062,cellular_component extracellular exosome;GO:0072229,biological_process metanephric proximal convoluted tubule development;GO:1902224,biological_process ketone body metabolic process;GO:1902860,biological_process propionyl-CoA biosynthetic process	E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]; K00626	acetyl-CoA acetyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:93]
ENSG00000176022	4.44	5.42	4.62	4.17	4.07	4.70	0.15713396375969	2.21422359565207	0.364212886355404	0.735845794822621	1:1232264-1235041:+	B3GALT6	17;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005797,cellular_component Golgi medial cisterna;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0008499,molecular_function UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0035250,molecular_function UDP-galactosyltransferase activity;GO:0047220,molecular_function galactosylxylosylprotein 3-beta-galactosyltransferase activity	B3GALT6; galactosylxylosylprotein 3-beta-galactosyltransferase [EC:2.4.1.134]; K00734	beta-1%2C3-galactosyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:17978]
ENSG00000198113	7.35	7.38	6.26	6.61	6.63	6.15	0.122612279894103	3.11645036187831	0.36421788152664	0.735845794822621	9:137277748-137282641:+	TOR4A	7;GO:0000166,molecular_function nucleotide binding;GO:0002576,biological_process platelet degranulation;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031093,cellular_component platelet alpha granule lumen	NA	torsin family 4 member A [Source:HGNC Symbol%3BAcc:HGNC:25981]
ENSG00000137185	9.69	10.38	11.22	10.46	11.17	12.01	-0.0951121056284068	4.10578434624951	0.364360871928326	0.735927836054992	6:28224885-28233482:+	ZSCAN9	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:12984]
ENSG00000115970	7.08	6.47	6.19	6.88	6.60	7.44	-0.0708477185569287	5.39381432789871	0.364377062788527	0.735927836054992	2:43230835-43596046:-	THADA	8;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0055088,biological_process lipid homeostasis;GO:0098554,cellular_component cytoplasmic side of endoplasmic reticulum membrane;GO:1901895,biological_process negative regulation of calcium-transporting ATPase activity;GO:1990845,biological_process adaptive thermogenesis	NA	THADA%2C armadillo repeat containing [Source:HGNC Symbol%3BAcc:HGNC:19217]
ENSG00000130147	33.15	31.72	32.69	36.67	32.87	33.18	-0.0617150557301036	6.59509091273076	0.364664687248799	0.736326415797208	2:234951972-235055714:+	SH3BP4	20;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005905,cellular_component clathrin-coated pit;GO:0006897,biological_process endocytosis;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010508,biological_process positive regulation of autophagy;GO:0016020,cellular_component membrane;GO:0017016,molecular_function Ras GTPase binding;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030308,biological_process negative regulation of cell growth;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032007,biological_process negative regulation of TOR signaling;GO:0034260,biological_process negative regulation of GTPase activity;GO:0042802,molecular_function identical protein binding;GO:0050790,biological_process regulation of catalytic activity;GO:0061462,biological_process protein localization to lysosome;GO:0070062,cellular_component extracellular exosome;GO:0071230,biological_process cellular response to amino acid stimulus	NA	SH3 domain binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:10826]
ENSG00000085377	15.69	15.84	13.97	13.45	14.47	15.53	0.0752857283346196	5.00738335224578	0.364693047959497	0.736326415797208	6:105277564-105403084:-	PREP	11;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0070008,molecular_function serine-type exopeptidase activity	PREP; prolyl oligopeptidase [EC:3.4.21.26]; K01322	prolyl endopeptidase [Source:HGNC Symbol%3BAcc:HGNC:9358]
ENSG00000103326	9.87	8.35	9.65	9.64	9.14	11.02	-0.0804028915781952	5.07452852311835	0.36481528948269	0.736396179194299	16:527716-554636:+	CAPN15	10;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	calpain 15 [Source:HGNC Symbol%3BAcc:HGNC:11182]
ENSG00000085276	6.41	7.98	5.54	5.99	6.43	6.20	0.101237545983691	4.61602700073433	0.364880562259056	0.736396179194299	3:169083498-169663618:-	MECOM	23;GO:0000118,cellular_component histone deacetylase complex;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0016607,cellular_component nuclear speck;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030154,biological_process cell differentiation;GO:0034968,biological_process histone lysine methylation;GO:0043069,biological_process negative regulation of programmed cell death;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle;GO:0071425,biological_process hematopoietic stem cell proliferation	MECOM, EVI1; ecotropic virus integration site 1 protein; K04462	MDS1 and EVI1 complex locus [Source:HGNC Symbol%3BAcc:HGNC:3498]
ENSG00000146066	135.70	156.27	140.49	145.98	160.03	150.81	-0.0718445156178395	5.56243826730888	0.364944217151422	0.736396179194299	5:176388746-176389771:+	HIGD2A	8;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NA	HIG1 hypoxia inducible domain family member 2A [Source:HGNC Symbol%3BAcc:HGNC:28311]
ENSG00000172428	44.78	43.68	37.24	45.60	45.29	42.82	-0.0787875181259744	5.03941542190263	0.365048165233493	0.736396179194299	2:240126562-240136807:-	COPS9	8;GO:0000790,cellular_component nuclear chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0008180,cellular_component COP9 signalosome;GO:0008284,biological_process positive regulation of cell proliferation;GO:0034644,biological_process cellular response to UV	NA	COP9 signalosome subunit 9 [Source:HGNC Symbol%3BAcc:HGNC:21314]
ENSG00000145912	124.38	127.94	131.54	131.49	136.91	134.31	-0.0575564769497514	6.32744802235592	0.365069226710807	0.736396179194299	5:178149459-178153967:-	NHP2	25;GO:0000469,biological_process cleavage involved in rRNA processing;GO:0000470,biological_process maturation of LSU-rRNA;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0007004,biological_process telomere maintenance via telomerase;GO:0015030,cellular_component Cajal body;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031118,biological_process rRNA pseudouridine synthesis;GO:0031120,biological_process snRNA pseudouridine synthesis;GO:0031429,cellular_component box H/ACA snoRNP complex;GO:0034513,molecular_function box H/ACA snoRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0070034,molecular_function telomerase RNA binding;GO:0072589,cellular_component box H/ACA scaRNP complex;GO:0090661,cellular_component box H/ACA telomerase RNP complex;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NHP2, NOLA2; H/ACA ribonucleoprotein complex subunit 2; K11129	NHP2 ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:14377]
ENSG00000203667	115.90	112.47	111.16	116.34	115.90	125.31	-0.0630723883630047	5.5082370290498	0.365109385531042	0.736396179194299	1:244835321-244845057:+	COX20	6;GO:0005739,cellular_component mitochondrion;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	COX20%2C cytochrome c oxidase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:26970]
ENSG00000151117	3.73	4.38	4.80	3.74	6.64	4.79	-0.220757797724778	1.81631969094977	0.365142873031573	0.736396179194299	11:18693121-18704785:+	TMEM86A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 86A [Source:HGNC Symbol%3BAcc:HGNC:26890]
ENSG00000100225	70.63	74.34	81.50	72.82	70.64	75.06	0.0634140112774468	6.89621036769881	0.365233753052583	0.736459807771558	22:32474675-32498829:+	FBXO7	34;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0000422,biological_process mitophagy;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006626,biological_process protein targeting to mitochondrion;GO:0010975,biological_process regulation of neuron projection development;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019901,molecular_function protein kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0040012,biological_process regulation of locomotion;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043130,molecular_function ubiquitin binding;GO:0043234,cellular_component protein complex;GO:0043687,biological_process post-translational protein modification;GO:0045620,biological_process negative regulation of lymphocyte differentiation;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0097409,cellular_component glial cytoplasmic inclusion;GO:0097414,cellular_component classical Lewy body;GO:0097462,cellular_component Lewy neurite;GO:1901215,biological_process negative regulation of neuron death;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death;GO:1903599,biological_process positive regulation of mitophagy;GO:1990037,cellular_component Lewy body core;GO:1990038,cellular_component Lewy body corona;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	F-box protein 7 [Source:HGNC Symbol%3BAcc:HGNC:13586]
ENSG00000104951	12.70	9.39	10.25	10.01	9.51	10.85	0.109350846328937	4.25291475603507	0.365324455926033	0.736474803991052	19:49889653-49929539:-	IL4I1	6;GO:0001716,molecular_function L-amino-acid oxidase activity;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	IL4I1; L-amino-acid oxidase [EC:1.4.3.2]; K03334	interleukin 4 induced 1 [Source:HGNC Symbol%3BAcc:HGNC:19094]
ENSG00000163788	8.22	7.54	7.76	8.42	8.16	8.58	-0.0823433214593136	4.23366479510799	0.365415003344523	0.736474803991052	3:43286511-43424764:+	SNRK	14;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030099,biological_process myeloid cell differentiation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	SNF related kinase [Source:HGNC Symbol%3BAcc:HGNC:30598]
ENSG00000166750	19.30	12.33	19.84	20.88	14.35	22.37	-0.147750430978518	5.61657270936116	0.365475711635028	0.736474803991052	17:35243035-35273655:+	SLFN5	4;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0030154,biological_process cell differentiation	NA	schlafen family member 5 [Source:HGNC Symbol%3BAcc:HGNC:28286]
ENSG00000068654	9.23	10.08	9.44	9.32	10.83	10.22	-0.0702987101028521	5.67208916499599	0.365492570809956	0.736474803991052	2:86020215-86106155:-	POLR1A	19;GO:0001054,molecular_function RNA polymerase I activity;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:1904750,biological_process negative regulation of protein localization to nucleolus	RPA1, POLR1A; DNA-directed RNA polymerase I subunit RPA1 [EC:2.7.7.6]; K02999	RNA polymerase I subunit A [Source:HGNC Symbol%3BAcc:HGNC:17264]
ENSG00000131143	375.45	356.55	337.23	372.66	365.94	383.16	-0.0574180536009331	7.8176848025412	0.365613428769862	0.736474803991052	16:85798632-85807044:+	COX4I1	14;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0007584,biological_process response to nutrient;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0070062,cellular_component extracellular exosome;GO:1902600,biological_process hydrogen ion transmembrane transport	COX4; cytochrome c oxidase subunit 4; K02263	cytochrome c oxidase subunit 4I1 [Source:HGNC Symbol%3BAcc:HGNC:2265]
ENSG00000196911	3.28	4.20	4.37	4.03	3.56	3.09	0.155738451932916	2.63003846283765	0.365651889676674	0.736474803991052	6:116681186-116741866:+	KPNA5	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0019054,biological_process modulation by virus of host process;GO:0043657,cellular_component host cell;GO:0075733,biological_process intracellular transport of virus	NA	karyopherin subunit alpha 5 [Source:HGNC Symbol%3BAcc:HGNC:6398]
ENSG00000131351	8.98	9.15	9.24	10.90	9.52	9.22	-0.103055756675129	3.58145470228393	0.365656506646004	0.736474803991052	19:17049728-17075625:-	HAUS8	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:30532]
ENSG00000206190	16.13	14.48	14.44	15.98	14.47	17.23	-0.0693286675351673	6.18325537287944	0.365766144051834	0.736576110661163	15:25677272-25865172:-	ATP10A	18;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008360,biological_process regulation of cell shape;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0034220,biological_process ion transmembrane transport;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding	NA	ATPase phospholipid transporting 10A (putative) [Source:HGNC Symbol%3BAcc:HGNC:13542]
ENSG00000166619	45.11	44.33	53.73	54.09	57.96	44.92	-0.114753397164252	3.73706155281127	0.365873577523993	0.73667294692706	20:37492471-37527931:-	BLCAP	6;GO:0005515,molecular_function protein binding;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030262,biological_process apoptotic nuclear changes	NA	bladder cancer associated protein [Source:HGNC Symbol%3BAcc:HGNC:1055]
ENSG00000132423	10.65	12.09	9.04	11.50	11.37	11.62	-0.117420570657102	3.62667638285764	0.366259977346368	0.737266201783617	6:99369399-99394204:-	COQ3	16;GO:0004395,molecular_function hexaprenyldihydroxybenzoate methyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006071,biological_process glycerol metabolic process;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0008168,molecular_function methyltransferase activity;GO:0008171,molecular_function O-methyltransferase activity;GO:0008425,molecular_function 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity;GO:0008689,molecular_function 3-demethylubiquinone-9 3-O-methyltransferase activity;GO:0010795,biological_process regulation of ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0044595,molecular_function decaprenyldihydroxybenzoate methyltransferase activity;GO:0044596,molecular_function 3-demethylubiquinone-10 3-O-methyltransferase activity	COQ3; polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase [EC:2.1.1.114 2.1.1.64]; K00591	coenzyme Q3%2C methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:18175]
ENSG00000079277	15.89	16.14	15.68	15.27	14.09	16.25	0.0734806312990397	4.78712650243482	0.366287010907884	0.737266201783617	1:46557407-46616843:-	MKNK1	21;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0009931,molecular_function calcium-dependent protein serine/threonine kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding	MKNK, MNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]; K04372	MAP kinase interacting serine/threonine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:7110]
ENSG00000168214	32.19	32.71	33.54	35.46	32.54	35.51	-0.0612141731098581	5.82905843847746	0.366558030881384	0.737692094249453	4:26163454-26435131:+	RBPJ	85;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000150,molecular_function recombinase activity;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0001756,biological_process somitogenesis;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001974,biological_process blood vessel remodeling;GO:0002193,cellular_component MAML1-RBP-Jkappa- ICN1 complex;GO:0002437,biological_process inflammatory response to antigenic stimulus;GO:0003139,biological_process secondary heart field specification;GO:0003151,biological_process outflow tract morphogenesis;GO:0003157,biological_process endocardium development;GO:0003160,biological_process endocardium morphogenesis;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003214,biological_process cardiac left ventricle morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003256,biological_process regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006959,biological_process humoral immune response;GO:0007219,biological_process Notch signaling pathway;GO:0007221,biological_process positive regulation of transcription of Notch receptor target;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009912,biological_process auditory receptor cell fate commitment;GO:0009957,biological_process epidermal cell fate specification;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0017053,cellular_component transcriptional repressor complex;GO:0021983,biological_process pituitary gland development;GO:0030097,biological_process hemopoiesis;GO:0030182,biological_process neuron differentiation;GO:0030183,biological_process B cell differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030279,biological_process negative regulation of ossification;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035912,biological_process dorsal aorta morphogenesis;GO:0036302,biological_process atrioventricular canal development;GO:0042127,biological_process regulation of cell proliferation;GO:0042742,biological_process defense response to bacterium;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045165,biological_process cell fate commitment;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047485,molecular_function protein N-terminus binding;GO:0048505,biological_process regulation of timing of cell differentiation;GO:0048733,biological_process sebaceous gland development;GO:0048820,biological_process hair follicle maturation;GO:0048844,biological_process artery morphogenesis;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060486,biological_process Clara cell differentiation;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0060844,biological_process arterial endothelial cell fate commitment;GO:0061314,biological_process Notch signaling involved in heart development;GO:0061419,biological_process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070491,molecular_function repressing transcription factor binding;GO:0072554,biological_process blood vessel lumenization;GO:0072602,biological_process interleukin-4 secretion;GO:0097101,biological_process blood vessel endothelial cell fate specification;GO:1901186,biological_process positive regulation of ERBB signaling pathway;GO:1901189,biological_process positive regulation of ephrin receptor signaling pathway;GO:1901297,biological_process positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment;GO:2000138,biological_process positive regulation of cell proliferation involved in heart morphogenesis	RBPSUH, RBPJK; recombining binding protein suppressor of hairless; K06053	recombination signal binding protein for immunoglobulin kappa J region [Source:HGNC Symbol%3BAcc:HGNC:5724]
ENSG00000162576	18.73	15.76	17.94	16.48	15.77	17.74	0.0865240917719516	4.58691046543685	0.366629248507623	0.737715814836298	1:1352688-1361777:-	MXRA8	9;GO:0003674,molecular_function molecular_function;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0060857,biological_process establishment of glial blood-brain barrier;GO:0070062,cellular_component extracellular exosome	NA	matrix remodeling associated 8 [Source:HGNC Symbol%3BAcc:HGNC:7542]
ENSG00000171227	16.67	20.41	17.27	14.52	21.21	13.53	0.149229620777837	3.53147576293131	0.366821961485857	0.737834498019735	2:119429900-119438520:+	TMEM37	9;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005262,molecular_function calcium channel activity;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport	NA	transmembrane protein 37 [Source:HGNC Symbol%3BAcc:HGNC:18216]
ENSG00000143067	5.23	4.27	5.00	4.63	5.38	6.06	-0.129402888169228	3.09323013512182	0.366822554769247	0.737834498019735	1:119619421-119647773:-	ZNF697	9;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 697 [Source:HGNC Symbol%3BAcc:HGNC:32034]
ENSG00000159352	112.27	113.08	109.28	116.73	119.37	114.45	-0.0555759680976229	7.11399192953458	0.366866552950762	0.737834498019735	1:151254702-151267479:+	PSMD4	38;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008134,molecular_function transcription factor binding;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031593,molecular_function polyubiquitin binding;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043248,biological_process proteasome assembly;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMD4, RPN10; 26S proteasome regulatory subunit N10; K03029	proteasome 26S subunit%2C non-ATPase 4 [Source:HGNC Symbol%3BAcc:HGNC:9561]
ENSG00000176715	8.39	7.84	8.60	8.38	9.35	8.92	-0.0850109651329947	4.12505467537605	0.367103764489884	0.738191969644083	16:89088374-89155846:+	ACSF3	15;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016874,molecular_function ligase activity;GO:0016878,molecular_function acid-thiol ligase activity;GO:0031957,molecular_function very long-chain fatty acid-CoA ligase activity;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0090409,molecular_function malonyl-CoA synthetase activity;GO:0090410,biological_process malonate catabolic process	NA	acyl-CoA synthetase family member 3 [Source:HGNC Symbol%3BAcc:HGNC:27288]
ENSG00000197548	19.61	18.52	19.13	21.05	18.83	20.55	-0.0647999945517565	5.47404420565598	0.367385675953789	0.738639195920697	3:11272308-11557665:+	ATG7	48;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0004839,molecular_function ubiquitin activating enzyme activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006464,biological_process cellular protein modification process;GO:0006497,biological_process protein lipidation;GO:0006501,biological_process C-terminal protein lipidation;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0007568,biological_process aging;GO:0008134,molecular_function transcription factor binding;GO:0008641,molecular_function small protein activating enzyme activity;GO:0009267,biological_process cellular response to starvation;GO:0009749,biological_process response to glucose;GO:0010508,biological_process positive regulation of autophagy;GO:0015031,biological_process protein transport;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0019778,molecular_function Atg12 activating enzyme activity;GO:0019779,molecular_function Atg8 activating enzyme activity;GO:0030424,cellular_component axon;GO:0031401,biological_process positive regulation of protein modification process;GO:0031667,biological_process response to nutrient levels;GO:0034727,biological_process piecemeal microautophagy of nucleus;GO:0034774,cellular_component secretory granule lumen;GO:0039521,biological_process suppression by virus of host autophagy;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0044805,biological_process late nucleophagy;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0051607,biological_process defense response to virus;GO:0060548,biological_process negative regulation of cell death;GO:0061025,biological_process membrane fusion;GO:0071315,biological_process cellular response to morphine;GO:0071455,biological_process cellular response to hyperoxia;GO:0075044,biological_process autophagy of host cells involved in interaction with symbiont;GO:0090298,biological_process negative regulation of mitochondrial DNA replication;GO:1901214,biological_process regulation of neuron death;GO:1902617,biological_process response to fluoride;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death;GO:1904813,cellular_component ficolin-1-rich granule lumen	ATG7; ubiquitin-like modifier-activating enzyme ATG7; K08337	autophagy related 7 [Source:HGNC Symbol%3BAcc:HGNC:16935]
ENSG00000143970	9.15	9.49	10.51	10.29	10.63	9.92	-0.0686895828827244	5.43531925733779	0.367611842118172	0.738766256355754	2:25733752-25878516:-	ASXL2	11;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016579,biological_process protein deubiquitination;GO:0035360,biological_process positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	additional sex combs like 2%2C transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:23805]
ENSG00000166199	30.97	26.25	27.79	29.62	28.34	32.81	-0.0785101834932891	4.88599010008049	0.367627952532581	0.738766256355754	11:43880810-43920266:+	ALKBH3	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008198,molecular_function ferrous iron binding;GO:0008283,biological_process cell proliferation;GO:0016491,molecular_function oxidoreductase activity;GO:0031418,molecular_function L-ascorbic acid binding;GO:0035552,biological_process oxidative single-stranded DNA demethylation;GO:0035553,biological_process oxidative single-stranded RNA demethylation;GO:0043734,molecular_function DNA-N1-methyladenine dioxygenase activity;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:1990930,molecular_function RNA N1-methyladenosine dioxygenase activity	NA	alkB homolog 3%2C alpha-ketoglutaratedependent dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:30141]
ENSG00000167778	12.29	10.04	9.22	10.11	10.19	9.25	0.111642495545473	3.88781024440221	0.367688118334329	0.738766256355754	12:53064315-53079420:-	SPRYD3	NA	NA	SPRY domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25920]
ENSG00000129696	8.76	8.84	9.47	8.99	9.21	7.11	0.112551267295806	3.748622431757	0.367723865569925	0.738766256355754	8:33473385-33513601:-	TTI2	3;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol	NA	TELO2 interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:26262]
ENSG00000183258	44.56	42.98	45.23	42.04	40.91	45.46	0.060532013358756	6.53850527006846	0.367792974951069	0.738766256355754	5:177511576-177517469:-	DDX41	30;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008283,biological_process cell proliferation;GO:0008380,biological_process RNA splicing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0032479,biological_process regulation of type I interferon production;GO:0032481,biological_process positive regulation of type I interferon production;GO:0035458,biological_process cellular response to interferon-beta;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	DEAD-box helicase 41 [Source:HGNC Symbol%3BAcc:HGNC:18674]
ENSG00000182712	106.98	95.10	108.60	100.56	101.87	94.10	0.0863908736897544	4.38097473096944	0.36780596667031	0.738766256355754	X:155061621-155071362:-	CMC4	3;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0008283,biological_process cell proliferation	NA	C-X9-C motif containing 4 [Source:HGNC Symbol%3BAcc:HGNC:35428]
ENSG00000182621	1.48	1.16	1.11	1.33	1.35	1.54	-0.150282392206885	2.49641126026829	0.368019977908887	0.738939225696706	20:8077250-8968360:+	PLCB1	56;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000790,cellular_component nuclear chromatin;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005096,molecular_function GTPase activator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005521,molecular_function lamin binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007215,biological_process glutamate receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007420,biological_process brain development;GO:0007613,biological_process memory;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0021987,biological_process cerebral cortex development;GO:0031965,cellular_component nuclear membrane;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0035556,biological_process intracellular signal transduction;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0035723,biological_process interleukin-15-mediated signaling pathway;GO:0040019,biological_process positive regulation of embryonic development;GO:0042803,molecular_function protein homodimerization activity;GO:0043209,cellular_component myelin sheath;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0045444,biological_process fat cell differentiation;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048639,biological_process positive regulation of developmental growth;GO:0051726,biological_process regulation of cell cycle;GO:0060466,biological_process activation of meiosis involved in egg activation;GO:0070062,cellular_component extracellular exosome;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0080154,biological_process regulation of fertilization;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:2000344,biological_process positive regulation of acrosome reaction;GO:2000438,biological_process negative regulation of monocyte extravasation;GO:2000560,biological_process positive regulation of CD24 biosynthetic process	PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]; K05858	phospholipase C beta 1 [Source:HGNC Symbol%3BAcc:HGNC:15917]
ENSG00000164675	2.35	2.66	2.48	2.12	2.62	2.08	0.144382335319635	2.5505974741167	0.368050931145088	0.738939225696706	7:123452399-123535077:-	IQUB	6;GO:0001669,cellular_component acrosomal vesicle;GO:0005515,molecular_function protein binding;GO:0007224,biological_process smoothened signaling pathway;GO:0030030,biological_process cell projection organization;GO:0031514,cellular_component motile cilium;GO:0060271,biological_process cilium morphogenesis	NA	IQ motif and ubiquitin domain containing [Source:HGNC Symbol%3BAcc:HGNC:21995]
ENSG00000188130	35.00	27.57	35.58	37.24	32.82	35.16	-0.0819817708522665	5.28809637527945	0.368150232243289	0.738939225696706	22:50245449-50261825:-	MAPK12	33;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007517,biological_process muscle organ development;GO:0010468,biological_process regulation of gene expression;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0045445,biological_process myoblast differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0051149,biological_process positive regulation of muscle cell differentiation	P38; p38 MAP kinase [EC:2.7.11.24]; K04441	mitogen-activated protein kinase 12 [Source:HGNC Symbol%3BAcc:HGNC:6874]
ENSG00000196935	16.64	14.56	16.40	17.89	15.84	16.65	-0.0664515436066631	5.75430458581444	0.368170822293852	0.738939225696706	12:63844292-64162221:+	SRGAP1	9;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0030336,biological_process negative regulation of cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048365,molecular_function Rac GTPase binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	SRGAP; SLIT-ROBO Rho GTPase activating protein; K07526	SLIT-ROBO Rho GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17382]
ENSG00000172869	7.96	7.84	8.06	7.76	9.23	8.19	-0.0659042786958913	6.22769826686546	0.368212150345297	0.738939225696706	5:119037771-119249138:+	DMXL1	3;GO:0007035,biological_process vacuolar acidification;GO:0043291,cellular_component RAVE complex;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly	NA	Dmx like 1 [Source:HGNC Symbol%3BAcc:HGNC:2937]
ENSG00000185753	13.14	11.78	13.46	14.79	13.55	13.23	-0.0953271970941262	3.69424014957383	0.368257277253524	0.738939225696706	X:40626920-40647554:-	CXorf38	NA	NA	chromosome X open reading frame 38 [Source:HGNC Symbol%3BAcc:HGNC:28589]
ENSG00000130313	77.83	69.18	69.36	71.55	65.84	71.33	0.0654344304268741	6.00296948416344	0.368325467181139	0.738939225696706	19:17511628-17521288:+	PGLS	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0009051,biological_process pentose-phosphate shunt, oxidative branch;GO:0016787,molecular_function hydrolase activity;GO:0017057,molecular_function 6-phosphogluconolactonase activity;GO:0070062,cellular_component extracellular exosome	PGLS, pgl, devB; 6-phosphogluconolactonase [EC:3.1.1.31]; K01057	6-phosphogluconolactonase [Source:HGNC Symbol%3BAcc:HGNC:8903]
ENSG00000157954	68.96	69.83	64.43	72.57	70.25	70.52	-0.059385573619889	6.60159262073366	0.368470489032961	0.738939225696706	7:5190187-5233826:+	WIPI2	19;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006497,biological_process protein lipidation;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0019898,cellular_component extrinsic component of membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0043234,cellular_component protein complex;GO:0044804,biological_process nucleophagy;GO:0061739,biological_process protein lipidation involved in autophagosome assembly;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:0098792,biological_process xenophagy	NA	WD repeat domain%2C phosphoinositide interacting 2 [Source:HGNC Symbol%3BAcc:HGNC:32225]
ENSG00000102543	3.95	4.69	3.89	4.10	3.58	3.76	0.131361376762885	2.69351499524129	0.368502296058181	0.738939225696706	13:49247924-49293485:+	CDADC1	4;GO:0003824,molecular_function catalytic activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	cytidine and dCMP deaminase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20299]
ENSG00000175003	0.59	0.69	0.84	0.81	0.78	1.06	-0.306467748151953	0.567166973759789	0.368505010854672	0.738939225696706	6:160121788-160158718:+	SLC22A1	35;GO:0005215,molecular_function transporter activity;GO:0005277,molecular_function acetylcholine transmembrane transporter activity;GO:0005329,molecular_function dopamine transmembrane transporter activity;GO:0005333,molecular_function norepinephrine transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006836,biological_process neurotransmitter transport;GO:0006855,biological_process drug transmembrane transport;GO:0008504,molecular_function monoamine transmembrane transporter activity;GO:0008513,molecular_function secondary active organic cation transmembrane transporter activity;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0015101,molecular_function organic cation transmembrane transporter activity;GO:0015651,molecular_function quaternary ammonium group transmembrane transporter activity;GO:0015695,biological_process organic cation transport;GO:0015697,biological_process quaternary ammonium group transport;GO:0015711,biological_process organic anion transport;GO:0015844,biological_process monoamine transport;GO:0015872,biological_process dopamine transport;GO:0015874,biological_process norepinephrine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0048241,biological_process epinephrine transport;GO:0051260,biological_process protein homooligomerization;GO:0055085,biological_process transmembrane transport;GO:0072488,biological_process ammonium transmembrane transport;GO:1901374,biological_process acetate ester transport	SLC22A1, OCT1; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 1; K08198	solute carrier family 22 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10963]
ENSG00000173068	7.90	8.76	7.18	7.69	9.21	8.58	-0.0891708796430081	4.87566009827438	0.368572911329922	0.738939225696706	9:16409502-16870843:-	BNC2	13;GO:0003416,biological_process endochondral bone growth;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0043586,biological_process tongue development;GO:0046872,molecular_function metal ion binding;GO:0060021,biological_process palate development;GO:0060485,biological_process mesenchyme development	NA	basonuclin 2 [Source:HGNC Symbol%3BAcc:HGNC:30988]
ENSG00000084234	699.55	676.74	686.51	664.76	662.17	682.68	0.0495272212044091	10.7320904980268	0.368606435633127	0.738939225696706	11:130069836-130144811:+	APLP2	20;GO:0002576,biological_process platelet degranulation;GO:0003677,molecular_function DNA binding;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008201,molecular_function heparin binding;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031092,cellular_component platelet alpha granule membrane;GO:0042802,molecular_function identical protein binding;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046914,molecular_function transition metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	amyloid beta precursor like protein 2 [Source:HGNC Symbol%3BAcc:HGNC:598]
ENSG00000006530	26.40	23.46	26.74	24.32	24.75	24.64	0.0730066619419743	5.06104366550466	0.368813922604669	0.73923578577293	7:141551188-141655244:+	AGK	21;GO:0000166,molecular_function nucleotide binding;GO:0001727,molecular_function lipid kinase activity;GO:0001729,molecular_function ceramide kinase activity;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046474,biological_process glycerophospholipid biosynthetic process;GO:0046486,biological_process glycerolipid metabolic process;GO:0046513,biological_process ceramide biosynthetic process;GO:0046834,biological_process lipid phosphorylation;GO:0047620,molecular_function acylglycerol kinase activity	AGK; acylglycerol kinase [EC:2.7.1.94]; K09881	acylglycerol kinase [Source:HGNC Symbol%3BAcc:HGNC:21869]
ENSG00000118096	23.61	20.73	21.63	25.03	22.36	23.04	-0.0777644400598866	4.61010397435625	0.36899144215598	0.73947219429806	11:118544527-118572970:-	IFT46	17;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0008022,molecular_function protein C-terminus binding;GO:0008150,biological_process biological_process;GO:0030992,cellular_component intraciliary transport particle B;GO:0031514,cellular_component motile cilium;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0050821,biological_process protein stabilization;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip	NA	intraflagellar transport 46 [Source:HGNC Symbol%3BAcc:HGNC:26146]
ENSG00000213625	90.87	90.09	101.45	86.21	97.93	86.77	0.0742787238062057	5.33595889810004	0.369300401174649	0.73982237220302	1:65420586-65436007:+	LEPROT	12;GO:0000139,cellular_component Golgi membrane;GO:0005102,molecular_function receptor binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032511,biological_process late endosome to vacuole transport via multivesicular body sorting pathway;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0060400,biological_process negative regulation of growth hormone receptor signaling pathway;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2000009,biological_process negative regulation of protein localization to cell surface	NA	leptin receptor overlapping transcript [Source:HGNC Symbol%3BAcc:HGNC:29477]
ENSG00000101911	26.53	27.57	24.65	28.77	28.12	26.62	-0.0758780955094047	4.81157558232657	0.369354530903895	0.73982237220302	X:12791354-12824222:+	PRPS2	27;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002189,cellular_component ribose phosphate diphosphokinase complex;GO:0004749,molecular_function ribose phosphate diphosphokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0006015,biological_process 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006167,biological_process AMP biosynthetic process;GO:0009116,biological_process nucleoside metabolic process;GO:0009156,biological_process ribonucleoside monophosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016208,molecular_function AMP binding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019003,molecular_function GDP binding;GO:0019693,biological_process ribose phosphate metabolic process;GO:0030246,molecular_function carbohydrate binding;GO:0031100,biological_process organ regeneration;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043531,molecular_function ADP binding;GO:0044249,biological_process cellular biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]; K00948	phosphoribosyl pyrophosphate synthetase 2 [Source:HGNC Symbol%3BAcc:HGNC:9465]
ENSG00000180638	0.82	0.86	0.58	0.75	0.40	0.67	0.306312669217957	0.517819205948703	0.36940837331272	0.73982237220302	17:19678287-19718979:-	SLC47A2	10;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0015238,molecular_function drug transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015307,molecular_function drug:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046618,biological_process drug export;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 47 member 2 [Source:HGNC Symbol%3BAcc:HGNC:26439]
ENSG00000100129	194.21	185.14	193.78	191.93	176.04	188.31	0.0550981552193546	8.58876477450247	0.369447452350139	0.73982237220302	22:37848867-37889407:+	EIF3L	17;GO:0001650,cellular_component fibrillar center;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016020,cellular_component membrane;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0075525,biological_process viral translational termination-reinitiation	NA	eukaryotic translation initiation factor 3 subunit L [Source:HGNC Symbol%3BAcc:HGNC:18138]
ENSG00000161204	29.97	27.62	29.47	28.65	33.18	30.10	-0.0643279346291186	5.99840662685708	0.369479519022245	0.73982237220302	3:184186022-184194012:+	ABCF3	7;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0045296,molecular_function cadherin binding;GO:0051607,biological_process defense response to virus	NA	ATP binding cassette subfamily F member 3 [Source:HGNC Symbol%3BAcc:HGNC:72]
ENSG00000106392	48.84	43.46	47.11	46.46	49.22	51.43	-0.0626513916462461	5.75806101016159	0.369601259698922	0.73982237220302	7:7156933-7248651:+	C1GALT1	17;GO:0000139,cellular_component Golgi membrane;GO:0001525,biological_process angiogenesis;GO:0001822,biological_process kidney development;GO:0005515,molecular_function protein binding;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016263,molecular_function glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity;GO:0016266,biological_process O-glycan processing;GO:0016267,biological_process O-glycan processing, core 1;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030154,biological_process cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0060576,biological_process intestinal epithelial cell development	C1GALT1; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:2.4.1.122]; K00731	core 1 synthase%2C glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:24337]
ENSG00000088451	9.75	11.83	11.78	10.41	8.31	11.92	0.127073194650119	3.50250401478818	0.369730627217269	0.73982237220302	13:94574050-94596257:-	TGDS	2;GO:0008460,molecular_function dTDP-glucose 4,6-dehydratase activity;GO:0016829,molecular_function lyase activity	E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]; K01710	TDP-glucose 4%2C6-dehydratase [Source:HGNC Symbol%3BAcc:HGNC:20324]
ENSG00000100201	196.47	187.41	204.02	187.50	191.89	191.87	0.0535692000703864	8.75711956590147	0.369802455841946	0.73982237220302	22:38483439-38507660:-	DDX17	40;GO:0000166,molecular_function nucleotide binding;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008186,molecular_function RNA-dependent ATPase activity;GO:0008380,biological_process RNA splicing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010586,biological_process miRNA metabolic process;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0030331,molecular_function estrogen receptor binding;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031047,biological_process gene silencing by RNA;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0045445,biological_process myoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051607,biological_process defense response to virus;GO:2001014,biological_process regulation of skeletal muscle cell differentiation	NA	DEAD-box helicase 17 [Source:HGNC Symbol%3BAcc:HGNC:2740]
ENSG00000100324	11.85	11.35	11.29	10.64	11.97	10.17	0.0886724854710464	4.16877579319294	0.369952451183752	0.73982237220302	22:39399740-39437060:+	TAB1	32;GO:0000185,biological_process activation of MAPKKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0001701,biological_process in utero embryonic development;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0003007,biological_process heart morphogenesis;GO:0003279,biological_process cardiac septum development;GO:0003824,molecular_function catalytic activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0008047,molecular_function enzyme activator activity;GO:0010008,cellular_component endosome membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0016607,cellular_component nuclear speck;GO:0019209,molecular_function kinase activator activity;GO:0030324,biological_process lung development;GO:0032403,molecular_function protein complex binding;GO:0035904,biological_process aorta development;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043234,cellular_component protein complex;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0048273,molecular_function mitogen-activated protein kinase p38 binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060976,biological_process coronary vasculature development;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway	MAP3K7IP1, TAB1; TAK1-binding protein 1; K04403	TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18157]
ENSG00000158796	31.19	31.21	31.16	32.70	32.33	33.61	-0.0651369935042194	5.07156495940839	0.370004025535033	0.73982237220302	1:161120973-161132688:-	DEDD	14;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007283,biological_process spermatogenesis;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042981,biological_process regulation of apoptotic process;GO:0046697,biological_process decidualization;GO:1901837,biological_process negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter	NA	death effector domain containing [Source:HGNC Symbol%3BAcc:HGNC:2755]
ENSG00000180900	18.20	18.21	17.27	17.67	16.82	17.51	0.0570204339449488	6.4742561500053	0.370027925372118	0.73982237220302	8:143790919-143815379:-	SCRIB	58;GO:0001843,biological_process neural tube closure;GO:0001921,biological_process positive regulation of receptor recycling;GO:0002093,biological_process auditory receptor cell morphogenesis;GO:0004385,molecular_function guanylate kinase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0007268,biological_process chemical synaptic transmission;GO:0007275,biological_process multicellular organism development;GO:0008105,biological_process asymmetric protein localization;GO:0008283,biological_process cell proliferation;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016080,biological_process synaptic vesicle targeting;GO:0016323,cellular_component basolateral plasma membrane;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016477,biological_process cell migration;GO:0021747,biological_process cochlear nucleus development;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0031252,cellular_component cell leading edge;GO:0034750,cellular_component Scrib-APC-beta-catenin complex;GO:0035089,biological_process establishment of apical/basal cell polarity;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035748,cellular_component myelin sheath abaxonal region;GO:0042060,biological_process wound healing;GO:0042734,cellular_component presynaptic membrane;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043113,biological_process receptor clustering;GO:0043615,biological_process astrocyte cell migration;GO:0044291,cellular_component cell-cell contact zone;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045211,cellular_component postsynaptic membrane;GO:0045296,molecular_function cadherin binding;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0050918,biological_process positive chemotaxis;GO:0060088,biological_process auditory receptor cell stereocilium organization;GO:0060561,biological_process apoptotic process involved in morphogenesis;GO:0060603,biological_process mammary gland duct morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071896,biological_process protein localization to adherens junction;GO:0090630,biological_process activation of GTPase activity;GO:0097120,biological_process receptor localization to synapse;GO:0098793,cellular_component presynapse;GO:0098887,biological_process neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0098968,biological_process neurotransmitter receptor transport postsynaptic membrane to endosome	SCRIB; protein scribble; K16175	scribbled planar cell polarity protein [Source:HGNC Symbol%3BAcc:HGNC:30377]
ENSG00000147905	23.82	20.84	20.14	22.50	23.40	22.85	-0.0706951411618063	5.19580768936351	0.370038815658402	0.73982237220302	9:37120538-37358149:+	ZCCHC7	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	AIR1_2; protein AIR1/2; K12597	zinc finger CCHC-type containing 7 [Source:HGNC Symbol%3BAcc:HGNC:26209]
ENSG00000144848	61.90	58.93	61.31	59.71	58.91	58.02	0.0579235484199373	5.92398690176304	0.370051793081033	0.73982237220302	3:112532508-112562046:-	ATG3	22;GO:0000045,biological_process autophagosome assembly;GO:0000153,cellular_component cytoplasmic ubiquitin ligase complex;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0019776,molecular_function Atg8 ligase activity;GO:0019777,molecular_function Atg12 transferase activity;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0019899,molecular_function enzyme binding;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0044804,biological_process nucleophagy;GO:0050765,biological_process negative regulation of phagocytosis;GO:1902017,biological_process regulation of cilium assembly	ATG3; ubiquitin-like-conjugating enzyme ATG3; K08343	autophagy related 3 [Source:HGNC Symbol%3BAcc:HGNC:20962]
ENSG00000135763	2.94	3.01	2.74	2.69	2.85	2.63	0.0969049805074534	3.69734816422347	0.370116157872563	0.73982237220302	1:229626233-229660199:+	URB2	5;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0016235,cellular_component aggresome;GO:0030496,cellular_component midbody;GO:0042254,biological_process ribosome biogenesis	NA	URB2 ribosome biogenesis 2 homolog (S. cerevisiae) [Source:HGNC Symbol%3BAcc:HGNC:28967]
ENSG00000126016	2.34	3.48	3.27	3.26	3.92	2.95	-0.153060217278302	3.40084306451991	0.370153993484828	0.73982237220302	X:112774502-112840815:-	AMOT	29;GO:0001570,biological_process vasculogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001726,cellular_component ruffle;GO:0003365,biological_process establishment of cell polarity involved in ameboidal cell migration;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005923,cellular_component bicellular tight junction;GO:0006935,biological_process chemotaxis;GO:0008180,cellular_component COP9 signalosome;GO:0009897,cellular_component external side of plasma membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0030334,biological_process regulation of cell migration;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034613,biological_process cellular protein localization;GO:0035329,biological_process hippo signaling;GO:0040019,biological_process positive regulation of embryonic development;GO:0042074,biological_process cell migration involved in gastrulation;GO:0043532,molecular_function angiostatin binding;GO:0043534,biological_process blood vessel endothelial cell migration;GO:0048514,biological_process blood vessel morphogenesis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	AMOT; angiomotin; K16819	angiomotin [Source:HGNC Symbol%3BAcc:HGNC:17810]
ENSG00000166166	16.11	14.29	15.65	14.51	14.95	14.09	0.0995290358760483	3.77204732350841	0.370158968307994	0.73982237220302	14:103529183-103537073:+	TRMT61A	10;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016429,molecular_function tRNA (adenine-N1-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0031515,cellular_component tRNA (m1A) methyltransferase complex;GO:0032259,biological_process methylation	NA	tRNA methyltransferase 61A [Source:HGNC Symbol%3BAcc:HGNC:23790]
ENSG00000095203	1.34	0.97	1.55	1.11	0.99	1.33	0.202062602808831	1.86551090937506	0.370179388846609	0.73982237220302	9:109171974-109320964:-	EPB41L4B	14;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0008092,molecular_function cytoskeletal protein binding;GO:0010628,biological_process positive regulation of gene expression;GO:0030054,cellular_component cell junction;GO:0031032,biological_process actomyosin structure organization;GO:0042060,biological_process wound healing;GO:0045177,cellular_component apical part of cell;GO:0045785,biological_process positive regulation of cell adhesion;GO:0051549,biological_process positive regulation of keratinocyte migration	NA	erythrocyte membrane protein band 4.1 like 4B [Source:HGNC Symbol%3BAcc:HGNC:19818]
ENSG00000123552	11.30	9.80	11.81	10.72	10.22	10.55	0.0827614787441098	4.75007043583826	0.370354335161114	0.740052859361704	6:99432378-99521728:-	USP45	15;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070911,biological_process global genome nucleotide-excision repair	NA	ubiquitin specific peptidase 45 [Source:HGNC Symbol%3BAcc:HGNC:20080]
ENSG00000087365	92.46	98.27	89.42	89.68	93.38	88.39	0.0565738241441382	7.94896132724459	0.370603512736365	0.740431579526235	11:66050728-66069308:+	SF3B2	15;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005684,cellular_component U2-type spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016032,biological_process viral process;GO:0016607,cellular_component nuclear speck;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	SF3B2, SAP145, CUS1; splicing factor 3B subunit 2; K12829	splicing factor 3b subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:10769]
ENSG00000128928	18.81	19.71	19.10	18.54	20.32	22.19	-0.0747804746608083	5.13279402129891	0.370769010365482	0.740611656085997	15:40405794-40435947:+	IVD	13;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006552,biological_process leucine catabolic process;GO:0008152,biological_process metabolic process;GO:0008470,molecular_function isovaleryl-CoA dehydrogenase activity;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0031966,cellular_component mitochondrial membrane;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	IVD, ivd; isovaleryl-CoA dehydrogenase [EC:1.3.8.4]; K00253	isovaleryl-CoA dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:6186]
ENSG00000177054	20.78	21.97	20.83	19.94	20.97	20.35	0.0624910308810755	5.28398829094145	0.37081297370293	0.740611656085997	11:19117098-19176422:+	ZDHHC13	17;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0007165,biological_process signal transduction;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:1903830,biological_process magnesium ion transmembrane transport	NA	zinc finger DHHC-type containing 13 [Source:HGNC Symbol%3BAcc:HGNC:18413]
ENSG00000172113	16.54	12.81	13.38	18.11	12.62	17.01	-0.14225023078147	3.3217672046547	0.371003197197928	0.740872375614203	3:48293263-48301685:-	NME6	18;GO:0000166,molecular_function nucleotide binding;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006183,biological_process GTP biosynthetic process;GO:0006228,biological_process UTP biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0009117,biological_process nucleotide metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030308,biological_process negative regulation of cell growth;GO:0045839,biological_process negative regulation of mitotic nuclear division;GO:0046872,molecular_function metal ion binding	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]; K00940	NME/NM23 nucleoside diphosphate kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:20567]
ENSG00000260097	0.94	1.19	0.98	0.68	0.88	0.93	0.30240723282809	0.341607550144637	0.371186545766973	0.740960308325481	7:102347205-102356444:-	SPDYE6	NA	NA	speedy/RINGO cell cycle regulator family member E6 [Source:HGNC Symbol%3BAcc:HGNC:35465]
ENSG00000152127	7.28	7.39	7.35	7.34	6.52	7.02	0.0868941179944838	4.00399934279484	0.371222197859972	0.740960308325481	2:134119982-134454621:+	MGAT5	11;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030144,molecular_function alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity;GO:0070062,cellular_component extracellular exosome	MGAT5; alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase [EC:2.4.1.155]; K00744	mannosyl (alpha-1%2C6-)-glycoprotein beta-1%2C6-N-acetyl-glucosaminyltransferase [Source:HGNC Symbol%3BAcc:HGNC:7049]
ENSG00000150990	7.61	7.49	6.77	6.99	6.70	7.21	0.0750033622168648	4.69387712280393	0.371281839623882	0.740960308325481	12:124946824-124989122:-	DHX37	12;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0016787,molecular_function hydrolase activity	NA	DEAH-box helicase 37 [Source:HGNC Symbol%3BAcc:HGNC:17210]
ENSG00000150779	125.79	113.05	104.15	125.52	114.26	124.78	-0.075369082748356	5.18155584033038	0.371326720504918	0.740960308325481	11:112084799-112086798:-	TIMM8B	15;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0007605,biological_process sensory perception of sound;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030001,biological_process metal ion transport;GO:0042719,cellular_component mitochondrial intermembrane space protein transporter complex;GO:0046872,molecular_function metal ion binding;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0072321,biological_process chaperone-mediated protein transport;GO:0098655,biological_process cation transmembrane transport	NA	translocase of inner mitochondrial membrane 8 homolog B [Source:HGNC Symbol%3BAcc:HGNC:11818]
ENSG00000005022	209.03	237.10	191.49	200.41	217.01	193.49	0.0723198022026765	7.54056799017799	0.371345692265594	0.740960308325481	X:119468399-119471319:+	SLC25A5	29;GO:0003723,molecular_function RNA binding;GO:0005215,molecular_function transporter activity;GO:0005471,molecular_function ATP:ADP antiporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0007059,biological_process chromosome segregation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0015207,molecular_function adenine transmembrane transporter activity;GO:0015853,biological_process adenine transport;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043209,cellular_component myelin sheath;GO:0045121,cellular_component membrane raft;GO:0050796,biological_process regulation of insulin secretion;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071817,cellular_component MMXD complex;GO:1901029,biological_process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1990830,biological_process cellular response to leukemia inhibitory factor	SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31; K05863	solute carrier family 25 member 5 [Source:HGNC Symbol%3BAcc:HGNC:10991]
ENSG00000125637	1.31	1.41	1.41	1.39	1.05	1.28	0.158471780963989	2.10712978342823	0.371473286988211	0.74101141505188	2:113157324-113209396:+	PSD4	10;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005543,molecular_function phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity	PSD; PH and SEC7 domain-containing protein; K12494	pleckstrin and Sec7 domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:19096]
ENSG00000178307	36.42	39.49	38.33	39.52	41.48	40.29	-0.0781497649760665	4.50854047775695	0.371516485041525	0.74101141505188	17:21197279-21214624:-	TMEM11	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007005,biological_process mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane	NA	transmembrane protein 11 [Source:HGNC Symbol%3BAcc:HGNC:16823]
ENSG00000048707	6.68	6.18	6.33	6.56	6.79	6.79	-0.0565332195401306	6.43682759396384	0.371609858276971	0.74101141505188	1:12230066-12512047:+	VPS13D	1;GO:0070062,cellular_component extracellular exosome	NA	vacuolar protein sorting 13 homolog D [Source:HGNC Symbol%3BAcc:HGNC:23595]
ENSG00000119392	20.38	21.91	23.47	22.14	20.16	20.89	0.0687565206740405	5.50604587027996	0.371651549876418	0.74101141505188	9:128504699-128542288:+	GLE1	21;GO:0000822,molecular_function inositol hexakisphosphate binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006406,biological_process mRNA export from nucleus;GO:0006446,biological_process regulation of translational initiation;GO:0006449,biological_process regulation of translational termination;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0031369,molecular_function translation initiation factor binding;GO:0031965,cellular_component nuclear membrane;GO:0042802,molecular_function identical protein binding;GO:0044614,cellular_component nuclear pore cytoplasmic filaments;GO:0051028,biological_process mRNA transport	NA	GLE1%2C RNA export mediator [Source:HGNC Symbol%3BAcc:HGNC:4315]
ENSG00000165678	128.08	136.75	130.28	124.50	129.70	128.81	0.0555129634162499	7.0705842128885	0.371669787328849	0.74101141505188	10:84139439-84153245:+	GHITM	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006915,biological_process apoptotic process;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	growth hormone inducible transmembrane protein [Source:HGNC Symbol%3BAcc:HGNC:17281]
ENSG00000240972	118.94	135.73	121.39	125.65	145.09	127.80	-0.0757326714938382	5.48093481683107	0.372071648408047	0.741693491519044	22:23894003-23895227:+	MIF	59;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0002906,biological_process negative regulation of mature B cell apoptotic process;GO:0004167,molecular_function dopachrome isomerase activity;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005126,molecular_function cytokine receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006954,biological_process inflammatory response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007569,biological_process cell aging;GO:0008283,biological_process cell proliferation;GO:0009986,cellular_component cell surface;GO:0010629,biological_process negative regulation of gene expression;GO:0010739,biological_process positive regulation of protein kinase A signaling;GO:0016853,molecular_function isomerase activity;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031666,biological_process positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0031982,cellular_component vesicle;GO:0032269,biological_process negative regulation of cellular protein metabolic process;GO:0033033,biological_process negative regulation of myeloid cell apoptotic process;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034774,cellular_component secretory granule lumen;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042056,molecular_function chemoattractant activity;GO:0042127,biological_process regulation of cell proliferation;GO:0042327,biological_process positive regulation of phosphorylation;GO:0043030,biological_process regulation of macrophage activation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045087,biological_process innate immune response;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0050178,molecular_function phenylpyruvate tautomerase activity;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050900,biological_process leukocyte migration;GO:0050918,biological_process positive chemotaxis;GO:0061078,biological_process positive regulation of prostaglandin secretion involved in immune response;GO:0061081,biological_process positive regulation of myeloid leukocyte cytokine production involved in immune response;GO:0070062,cellular_component extracellular exosome;GO:0070207,biological_process protein homotrimerization;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0090238,biological_process positive regulation of arachidonic acid secretion;GO:0090344,biological_process negative regulation of cell aging;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2000343,biological_process positive regulation of chemokine (C-X-C motif) ligand 2 production	NA	macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Source:HGNC Symbol%3BAcc:HGNC:7097]
ENSG00000241553	1.58	0.82	1.52	1.81	1.96	1.33	-0.313568275831593	0.054181791135877	0.372206038662614	0.741842254001129	3:9792494-9807726:+	ARPC4	20;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0015629,cellular_component actin cytoskeleton;GO:0019899,molecular_function enzyme binding;GO:0030041,biological_process actin filament polymerization;GO:0030674,molecular_function protein binding, bridging;GO:0030833,biological_process regulation of actin filament polymerization;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0045010,biological_process actin nucleation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	ARPC4; actin related protein 2/3 complex, subunit 4; K05755	actin related protein 2/3 complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:707]
ENSG00000103187	121.83	133.68	129.85	129.15	137.53	138.15	-0.0617421858403456	6.07045137343597	0.372379219325406	0.74206826930266	16:84565593-84618077:-	COTL1	14;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0008150,biological_process biological_process;GO:0019899,molecular_function enzyme binding;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0050832,biological_process defense response to fungus;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	coactosin like F-actin binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18304]
ENSG00000151414	18.17	16.69	20.32	16.94	18.16	17.36	0.0911497363139041	4.27057374259502	0.37257238759418	0.742334036469751	1:198156962-198322420:+	NEK7	22;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0000922,cellular_component spindle pole;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0046872,molecular_function metal ion binding;GO:0051225,biological_process spindle assembly;GO:0051973,biological_process positive regulation of telomerase activity;GO:1904355,biological_process positive regulation of telomere capping	NA	NIMA related kinase 7 [Source:HGNC Symbol%3BAcc:HGNC:13386]
ENSG00000170315	1060.52	1219.82	1050.45	1160.35	1261.94	1099.50	-0.0689569481707166	9.61694103136947	0.372699591178756	0.742374604836604	17:16380797-16382745:+	UBB	105;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0000209,biological_process protein polyubiquitination;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005978,biological_process glycogen biosynthetic process;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006457,biological_process protein folding;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007219,biological_process Notch signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016055,biological_process Wnt signaling pathway;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019058,biological_process viral life cycle;GO:0019068,biological_process virion assembly;GO:0019985,biological_process translesion synthesis;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031982,cellular_component vesicle;GO:0032479,biological_process regulation of type I interferon production;GO:0032480,biological_process negative regulation of type I interferon production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034220,biological_process ion transmembrane transport;GO:0035635,biological_process entry of bacterium into host cell;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0036297,biological_process interstrand cross-link repair;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043657,cellular_component host cell;GO:0044267,biological_process cellular protein metabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0045087,biological_process innate immune response;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0048812,biological_process neuron projection morphogenesis;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060544,biological_process regulation of necroptotic process;GO:0061024,biological_process membrane organization;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070987,biological_process error-free translesion synthesis;GO:0075733,biological_process intracellular transport of virus;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901214,biological_process regulation of neuron death;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1902255,biological_process positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:1902527,biological_process positive regulation of protein monoubiquitination;GO:1904380,biological_process endoplasmic reticulum mannose trimming	UBB; ubiquitin B; K04551	ubiquitin B [Source:HGNC Symbol%3BAcc:HGNC:12463]
ENSG00000120875	2.74	2.92	2.80	2.57	1.30	3.30	0.240910104981595	1.8669369916729	0.372712361020037	0.742374604836604	8:29333063-29350668:-	DUSP4	17;GO:0000188,biological_process inactivation of MAPK activity;GO:0001706,biological_process endoderm formation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008330,molecular_function protein tyrosine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:1990439,molecular_function MAP kinase threonine phosphatase activity	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 4 [Source:HGNC Symbol%3BAcc:HGNC:3070]
ENSG00000172409	8.21	9.35	9.62	7.67	8.70	9.03	0.104440114565148	3.53600802313719	0.372875208447797	0.742497623480661	11:57648991-57661868:+	CLP1	24;GO:0000166,molecular_function nucleotide binding;GO:0000214,cellular_component tRNA-intron endonuclease complex;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005849,cellular_component mRNA cleavage factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006379,biological_process mRNA cleavage;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0008033,biological_process tRNA processing;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0021695,biological_process cerebellar cortex development;GO:0030423,biological_process targeting of mRNA for destruction involved in RNA interference;GO:0031124,biological_process mRNA 3'-end processing;GO:0035087,biological_process siRNA loading onto RISC involved in RNA interference;GO:0046404,molecular_function ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051733,molecular_function polydeoxyribonucleotide kinase activity;GO:0051736,molecular_function ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity	CLP1, HERB; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]; K14399	cleavage and polyadenylation factor I subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:16999]
ENSG00000168393	58.56	58.20	53.84	60.40	58.97	59.89	-0.0609773533453441	5.70255271925142	0.372893755319298	0.742497623480661	2:241675741-241686991:-	DTYMK	26;GO:0000166,molecular_function nucleotide binding;GO:0004798,molecular_function thymidylate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006227,biological_process dUDP biosynthetic process;GO:0006233,biological_process dTDP biosynthetic process;GO:0006235,biological_process dTTP biosynthetic process;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0009041,molecular_function uridylate kinase activity;GO:0009165,biological_process nucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043627,biological_process response to estrogen;GO:0045445,biological_process myoblast differentiation;GO:0046686,biological_process response to cadmium ion;GO:0046939,biological_process nucleotide phosphorylation;GO:0046940,biological_process nucleoside monophosphate phosphorylation;GO:0050145,molecular_function nucleoside phosphate kinase activity;GO:0071363,biological_process cellular response to growth factor stimulus	tmk, DTYMK; dTMP kinase [EC:2.7.4.9]; K00943	deoxythymidylate kinase [Source:HGNC Symbol%3BAcc:HGNC:3061]
ENSG00000172264	3.00	4.41	3.89	3.18	4.06	2.72	0.182255109936688	2.28141257829557	0.373143544891329	0.742774898911191	20:13995368-16053197:+	MACROD2	10;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005813,cellular_component centrosome;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007420,biological_process brain development;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019213,molecular_function deacetylase activity;GO:0042278,biological_process purine nucleoside metabolic process;GO:0051725,biological_process protein de-ADP-ribosylation	NA	MACRO domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:16126]
ENSG00000140400	18.12	15.49	18.33	16.38	16.57	17.13	0.0685626816183244	5.89059910806263	0.373152684251203	0.742774898911191	15:75355206-75368630:-	MAN2C1	15;GO:0003824,molecular_function catalytic activity;GO:0004559,molecular_function alpha-mannosidase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005773,cellular_component vacuole;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006013,biological_process mannose metabolic process;GO:0006517,biological_process protein deglycosylation;GO:0008152,biological_process metabolic process;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	MAN2C1; alpha-mannosidase [EC:3.2.1.24]; K01191	mannosidase alpha class 2C member 1 [Source:HGNC Symbol%3BAcc:HGNC:6827]
ENSG00000131381	8.74	7.11	8.67	8.85	8.33	9.18	-0.0837513521089461	4.43010209961689	0.373286765535289	0.742922658423849	3:15070072-15099163:-	RBSN	25;GO:0000011,biological_process vacuole inheritance;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0006897,biological_process endocytosis;GO:0007596,biological_process blood coagulation;GO:0008270,molecular_function zinc ion binding;GO:0010008,cellular_component endosome membrane;GO:0010009,cellular_component cytoplasmic side of endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0017137,molecular_function Rab GTPase binding;GO:0031901,cellular_component early endosome membrane;GO:0034058,biological_process endosomal vesicle fusion;GO:0034498,biological_process early endosome to Golgi transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0090160,biological_process Golgi to lysosome transport;GO:1903358,biological_process regulation of Golgi organization	RBSN, ZFYVE20; rabenosyn-5; K12481	rabenosyn%2C RAB effector [Source:HGNC Symbol%3BAcc:HGNC:20759]
ENSG00000066651	18.77	19.03	18.78	19.85	18.22	22.13	-0.0799396850713783	4.78921413086824	0.373389259728834	0.743007515391795	6:125986429-126039276:+	TRMT11	9;GO:0000049,molecular_function tRNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004809,molecular_function tRNA (guanine-N2-)-methyltransferase activity;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	tRNA methyltransferase 11 homolog [Source:HGNC Symbol%3BAcc:HGNC:21080]
ENSG00000145982	10.46	9.46	9.34	10.26	11.18	10.10	-0.0924898827461255	3.80742766470629	0.373500018427176	0.743022327568992	6:5261043-5771580:+	FARS2	15;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004826,molecular_function phenylalanine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006432,biological_process phenylalanyl-tRNA aminoacylation;GO:0008033,biological_process tRNA processing;GO:0016874,molecular_function ligase activity;GO:0043039,biological_process tRNA aminoacylation	FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]; K01889	phenylalanyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:21062]
ENSG00000175536	2.61	2.09	2.72	2.87	2.91	3.08	-0.226118736629706	1.10575107168911	0.373516420207082	0.743022327568992	11:74491711-74493733:-	LIPT2	11;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006464,biological_process cellular protein modification process;GO:0009107,biological_process lipoate biosynthetic process;GO:0009249,biological_process protein lipoylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016874,molecular_function ligase activity;GO:0033819,molecular_function lipoyl(octanoyl) transferase activity;GO:0034641,biological_process cellular nitrogen compound metabolic process	lipB; lipoyl(octanoyl) transferase [EC:2.3.1.181]; K03801	lipoyl(octanoyl) transferase 2 (putative) [Source:HGNC Symbol%3BAcc:HGNC:37216]
ENSG00000008311	13.57	13.10	13.16	12.44	13.58	12.35	0.0668924996987348	5.22296123719867	0.373673368013736	0.743215432968194	7:122075646-122144280:-	AASS	16;GO:0003824,molecular_function catalytic activity;GO:0004753,molecular_function saccharopine dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006554,biological_process lysine catabolic process;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0019477,biological_process L-lysine catabolic process;GO:0019878,biological_process lysine biosynthetic process via aminoadipic acid;GO:0033512,biological_process L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0047130,molecular_function saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0047131,molecular_function saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;GO:0051262,biological_process protein tetramerization;GO:0055114,biological_process oxidation-reduction process	AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]; K14157	aminoadipate-semialdehyde synthase [Source:HGNC Symbol%3BAcc:HGNC:17366]
ENSG00000116670	62.95	65.42	60.69	68.31	65.12	65.26	-0.0621095197887946	5.63043982899927	0.373793378860597	0.743335022716531	1:11674479-11691650:-	MAD2L2	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001558,biological_process regulation of cell growth;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007015,biological_process actin filament organization;GO:0007049,biological_process cell cycle;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0008432,molecular_function JUN kinase binding;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0010944,biological_process negative regulation of transcription by competitive promoter binding;GO:0016035,cellular_component zeta DNA polymerase complex;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042276,biological_process error-prone translesion synthesis;GO:0042772,biological_process DNA damage response, signal transduction resulting in transcription;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051301,biological_process cell division;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1904667,biological_process negative regulation of ubiquitin protein ligase activity;GO:2000048,biological_process negative regulation of cell-cell adhesion mediated by cadherin;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding	MAD2L2; mitotic spindle assembly checkpoint protein MAD2B; K13728	mitotic arrest deficient 2 like 2 [Source:HGNC Symbol%3BAcc:HGNC:6764]
ENSG00000086200	6.05	6.74	7.18	7.42	6.88	7.02	-0.0853879940933852	4.42888844872803	0.37393036059157	0.743429985387818	5:62403971-62628582:+	IPO11	14;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0042991,biological_process transcription factor import into nucleus	NA	importin 11 [Source:HGNC Symbol%3BAcc:HGNC:20628]
ENSG00000070610	16.32	14.98	15.56	15.17	15.76	14.32	0.0653435768311739	5.57577677119489	0.373960914264202	0.743429985387818	9:35736865-35749228:-	GBA2	22;GO:0000139,cellular_component Golgi membrane;GO:0003824,molecular_function catalytic activity;GO:0004348,molecular_function glucosylceramidase activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006680,biological_process glucosylceramide catabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008206,biological_process bile acid metabolic process;GO:0008422,molecular_function beta-glucosidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016139,biological_process glycoside catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0021954,biological_process central nervous system neuron development	GBA2; non-lysosomal glucosylceramidase [EC:3.2.1.45]; K17108	glucosylceramidase beta 2 [Source:HGNC Symbol%3BAcc:HGNC:18986]
ENSG00000163694	22.67	24.95	22.86	23.34	27.03	24.18	-0.0722273552787625	5.47548374950808	0.374091779052605	0.743571057386708	4:40423266-40630875:-	RBM47	5;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0016554,biological_process cytidine to uridine editing	NA	RNA binding motif protein 47 [Source:HGNC Symbol%3BAcc:HGNC:30358]
ENSG00000219200	47.82	47.00	47.30	45.17	46.38	45.19	0.0682943059859209	4.83349316050025	0.374423338874708	0.744042276488601	17:7012416-7014532:+	RNASEK	10;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0005575,cellular_component cellular_component;GO:0009303,biological_process rRNA transcription;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	ribonuclease K [Source:HGNC Symbol%3BAcc:HGNC:33911]
ENSG00000026508	120.85	106.21	116.44	117.49	93.41	117.36	0.0776773189183665	7.98162101426528	0.374501107596774	0.744042276488601	11:35138869-35232402:+	CD44	42;GO:0004896,molecular_function cytokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0030214,biological_process hyaluronan catabolic process;GO:0030667,cellular_component secretory granule membrane;GO:0031258,cellular_component lamellipodium membrane;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033674,biological_process positive regulation of kinase activity;GO:0034116,biological_process positive regulation of heterotypic cell-cell adhesion;GO:0035692,cellular_component macrophage migration inhibitory factor receptor complex;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044319,biological_process wound healing, spreading of cells;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050900,biological_process leukocyte migration;GO:0051216,biological_process cartilage development;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070487,biological_process monocyte aggregation;GO:1900625,biological_process positive regulation of monocyte aggregation;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000392,biological_process regulation of lamellipodium morphogenesis	CD44; CD44 antigen; K06256	CD44 molecule (Indian blood group) [Source:HGNC Symbol%3BAcc:HGNC:1681]
ENSG00000170892	78.50	81.61	74.94	70.47	79.38	77.09	0.0608500422521631	6.24936111888572	0.374575119866798	0.744042276488601	19:54189937-54194536:+	TSEN34	14;GO:0000213,molecular_function tRNA-intron endonuclease activity;GO:0000214,cellular_component tRNA-intron endonuclease complex;GO:0000379,biological_process tRNA-type intron splice site recognition and cleavage;GO:0004519,molecular_function endonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0008033,biological_process tRNA processing;GO:0016829,molecular_function lyase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	tRNA splicing endonuclease subunit 34 [Source:HGNC Symbol%3BAcc:HGNC:15506]
ENSG00000103152	41.01	43.31	38.80	41.43	38.58	38.22	0.0668339001970891	5.21143374613286	0.374603370282943	0.744042276488601	16:77006-85853:+	MPG	23;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003824,molecular_function catalytic activity;GO:0003905,molecular_function alkylbase DNA N-glycosylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008725,molecular_function DNA-3-methyladenine glycosylase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043916,molecular_function DNA-7-methylguanine glycosylase activity;GO:0045007,biological_process depurination;GO:0052821,molecular_function DNA-7-methyladenine glycosylase activity;GO:0052822,molecular_function DNA-3-methylguanine glycosylase activity	MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]; K03652	N-methylpurine DNA glycosylase [Source:HGNC Symbol%3BAcc:HGNC:7211]
ENSG00000167363	2.97	2.16	3.33	2.18	1.23	3.64	0.280715306430899	1.36793353638569	0.374654918934543	0.744042276488601	17:82735574-82751197:+	FN3K	10;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030387,molecular_function fructosamine-3-kinase activity;GO:0030389,biological_process fructosamine metabolic process;GO:0030393,biological_process fructoselysine metabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0043687,biological_process post-translational protein modification	NA	fructosamine 3 kinase [Source:HGNC Symbol%3BAcc:HGNC:24822]
ENSG00000169515	3.94	4.80	3.42	4.59	4.56	4.31	-0.151175043297496	2.81007924406794	0.374730315433438	0.744042276488601	19:46410371-46413584:-	CCDC8	13;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0043687,biological_process post-translational protein modification;GO:1990393,cellular_component 3M complex	NA	coiled-coil domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:25367]
ENSG00000063169	2.94	2.65	3.24	2.77	2.74	2.84	0.101675020998126	3.76467497398187	0.374748434109944	0.744042276488601	19:47608195-47703277:+	BICRA	1;GO:0005515,molecular_function protein binding	NA	BRD4 interacting chromatin remodeling complex associated protein [Source:HGNC Symbol%3BAcc:HGNC:4332]
ENSG00000182902	1.35	0.81	0.70	1.66	0.96	1.12	-0.352877422618974	0.266503178137188	0.374962631489194	0.744252492897476	22:17563438-17590994:+	SLC25A18	14;GO:0005280,molecular_function hydrogen:amino acid symporter activity;GO:0005314,molecular_function high-affinity glutamate transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006839,biological_process mitochondrial transport;GO:0015293,molecular_function symporter activity;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0089711,biological_process L-glutamate transmembrane transport	NA	solute carrier family 25 member 18 [Source:HGNC Symbol%3BAcc:HGNC:10988]
ENSG00000120658	0.62	0.54	0.38	0.31	0.35	0.55	0.350976439560725	0.0547500143732703	0.375025169361076	0.744252492897476	13:43213517-43786908:-	ENOX1	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0048511,biological_process rhythmic process;GO:0055114,biological_process oxidation-reduction process	NA	ecto-NOX disulfide-thiol exchanger 1 [Source:HGNC Symbol%3BAcc:HGNC:25474]
ENSG00000266173	17.45	17.20	16.62	15.17	16.14	17.66	0.076238259244294	4.61911443765499	0.375034185376115	0.744252492897476	17:63682335-63741986:-	STRADA	20;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006611,biological_process protein export from nucleus;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0019900,molecular_function kinase binding;GO:0030295,molecular_function protein kinase activator activity;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity	STRADA, LYK5; STE20-related kinase adapter protein alpha; K08271	STE20-related kinase adaptor alpha [Source:HGNC Symbol%3BAcc:HGNC:30172]
ENSG00000173915	271.54	282.30	264.79	254.31	266.32	269.96	0.0594923436248317	5.54888123818463	0.375514277844425	0.745086114271555	10:103389040-103396466:-	USMG5	7;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0070062,cellular_component extracellular exosome	NA	up-regulated during skeletal muscle growth 5 homolog (mouse) [Source:HGNC Symbol%3BAcc:HGNC:30889]
ENSG00000108384	10.07	9.62	11.68	12.38	10.42	11.21	-0.0997205670949375	3.90972341135894	0.375648944071942	0.74523419254675	17:58692572-58735611:+	RAD51C	40;GO:0000150,molecular_function recombinase activity;GO:0000166,molecular_function nucleotide binding;GO:0000400,molecular_function four-way junction DNA binding;GO:0000707,biological_process meiotic DNA recombinase assembly;GO:0000722,biological_process telomere maintenance via recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006312,biological_process mitotic recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007062,biological_process sister chromatid cohesion;GO:0007066,biological_process female meiosis sister chromatid cohesion;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007141,biological_process male meiosis I;GO:0007283,biological_process spermatogenesis;GO:0007596,biological_process blood coagulation;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0010212,biological_process response to ionizing radiation;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0030054,cellular_component cell junction;GO:0033063,cellular_component Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0033065,cellular_component Rad51C-XRCC3 complex;GO:0042148,biological_process strand invasion;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048476,cellular_component Holliday junction resolvase complex	RAD51L2, RAD51C; RAD51-like protein 2; K10870	RAD51 paralog C [Source:HGNC Symbol%3BAcc:HGNC:9820]
ENSG00000004487	50.68	50.93	50.97	52.52	53.17	53.91	-0.0533015747014577	7.12072554472391	0.375747034818348	0.745309674528627	1:23019447-23083689:+	KDM1A	63;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000790,cellular_component nuclear chromatin;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006482,biological_process protein demethylation;GO:0007275,biological_process multicellular organism development;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014070,biological_process response to organic cyclic compound;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0019899,molecular_function enzyme binding;GO:0021987,biological_process cerebral cortex development;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0032091,biological_process negative regulation of protein binding;GO:0032451,molecular_function demethylase activity;GO:0032452,molecular_function histone demethylase activity;GO:0032453,molecular_function histone demethylase activity (H3-K4 specific);GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0033184,biological_process positive regulation of histone ubiquitination;GO:0034644,biological_process cellular response to UV;GO:0034648,molecular_function histone demethylase activity (H3-dimethyl-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0035563,biological_process positive regulation of chromatin binding;GO:0042162,molecular_function telomeric DNA binding;GO:0042551,biological_process neuron maturation;GO:0043234,cellular_component protein complex;GO:0043392,biological_process negative regulation of DNA binding;GO:0043426,molecular_function MRF binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045793,biological_process positive regulation of cell size;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046098,biological_process guanine metabolic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050681,molecular_function androgen receptor binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0055001,biological_process muscle cell development;GO:0055114,biological_process oxidation-reduction process;GO:0060992,biological_process response to fungicide;GO:0061752,molecular_function telomeric repeat-containing RNA binding;GO:0071320,biological_process cellular response to cAMP;GO:0071480,biological_process cellular response to gamma radiation;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1903827,biological_process regulation of cellular protein localization;GO:1990391,cellular_component DNA repair complex	KDM1A, AOF2, LSD1; [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase [EC:1.14.99.66]; K11450	lysine demethylase 1A [Source:HGNC Symbol%3BAcc:HGNC:29079]
ENSG00000101187	46.95	42.32	48.41	58.00	36.16	56.45	-0.117253863588198	6.77165806751684	0.375829437218625	0.745354018883974	20:62642444-62685785:+	SLCO4A1	11;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015347,molecular_function sodium-independent organic anion transmembrane transporter activity;GO:0015349,molecular_function thyroid hormone transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043252,biological_process sodium-independent organic anion transport;GO:0070327,biological_process thyroid hormone transport	NA	solute carrier organic anion transporter family member 4A1 [Source:HGNC Symbol%3BAcc:HGNC:10953]
ENSG00000170579	0.75	0.96	0.54	0.82	0.42	0.64	0.248577888830408	1.25327827546507	0.376055461837544	0.74568313862451	18:3496031-4455335:-	DLGAP1	12;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0007268,biological_process chemical synaptic transmission;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0023052,biological_process signaling;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	DLGAP1, GKAP; discs, large-associated protein 1; K15008	DLG associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2905]
ENSG00000131051	129.48	124.89	129.05	124.48	122.83	125.89	0.0510868017674396	8.15342509363623	0.376117963014162	0.745687953185559	20:35701346-35742312:-	RBM39	13;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016607,cellular_component nuclear speck	NA	RNA binding motif protein 39 [Source:HGNC Symbol%3BAcc:HGNC:15923]
ENSG00000154127	20.17	20.27	19.13	21.73	14.37	19.76	0.103383146206125	5.23325946380003	0.376389101318535	0.74610634216975	11:122655674-122814473:+	UBASH3B	22;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0009968,biological_process negative regulation of signal transduction;GO:0016787,molecular_function hydrolase activity;GO:0030168,biological_process platelet activation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0038065,biological_process collagen-activated signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043393,biological_process regulation of protein binding;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045779,biological_process negative regulation of bone resorption;GO:0051219,molecular_function phosphoprotein binding;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0070527,biological_process platelet aggregation;GO:0090331,biological_process negative regulation of platelet aggregation	NA	ubiquitin associated and SH3 domain containing B [Source:HGNC Symbol%3BAcc:HGNC:29884]
ENSG00000141759	73.88	83.31	76.14	69.45	77.96	76.68	0.065868412974941	5.53809485305077	0.376472532680901	0.746152570360535	18:79970810-80033949:-	TXNL4A	16;GO:0000245,biological_process spliceosomal complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0008380,biological_process RNA splicing;GO:0031965,cellular_component nuclear membrane;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0051301,biological_process cell division	TXNL4A, DIB1; U5 snRNP protein, DIM1 family; K12859	thioredoxin like 4A [Source:HGNC Symbol%3BAcc:HGNC:30551]
ENSG00000105519	7.88	7.88	9.64	6.35	7.35	9.38	0.149286446522333	2.77313681699638	0.376785946440041	0.746613379643641	19:5911706-5915877:+	CAPS	1;GO:0005509,molecular_function calcium ion binding	NA	calcyphosine [Source:HGNC Symbol%3BAcc:HGNC:1487]
ENSG00000187372	0.41	0.20	0.65	0.56	0.70	0.38	-0.316603965541056	0.410615890851331	0.376904967460263	0.746613379643641	5:141213918-141218979:+	PCDHB13	10;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007268,biological_process chemical synaptic transmission;GO:0007416,biological_process synapse assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NA	protocadherin beta 13 [Source:HGNC Symbol%3BAcc:HGNC:8684]
ENSG00000173614	16.64	16.78	17.17	16.87	18.29	19.03	-0.0888146491761752	3.96315544139926	0.376935149205975	0.746613379643641	1:9943427-9985501:+	NMNAT1	19;GO:0000166,molecular_function nucleotide binding;GO:0000309,molecular_function nicotinamide-nucleotide adenylyltransferase activity;GO:0003824,molecular_function catalytic activity;GO:0004515,molecular_function nicotinate-nucleotide adenylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0009058,biological_process biosynthetic process;GO:0009435,biological_process NAD biosynthetic process;GO:0009611,biological_process response to wounding;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0019674,biological_process NAD metabolic process;GO:0034628,biological_process 'de novo' NAD biosynthetic process from aspartate;GO:0042802,molecular_function identical protein binding;GO:1990966,biological_process ATP generation from poly-ADP-D-ribose	NMNAT; nicotinamide mononucleotide adenylyltransferase [EC:2.7.7.1 2.7.7.18]; K06210	nicotinamide nucleotide adenylyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:17877]
ENSG00000141562	12.87	14.05	11.83	11.76	12.59	12.52	0.0772622304948313	4.5866538174166	0.377004563630225	0.746613379643641	17:82458179-82490537:+	NARF	8;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005638,cellular_component lamin filament;GO:0005652,cellular_component nuclear lamina;GO:0005730,cellular_component nucleolus;GO:0031981,cellular_component nuclear lumen;GO:0055114,biological_process oxidation-reduction process	NA	nuclear prelamin A recognition factor [Source:HGNC Symbol%3BAcc:HGNC:29916]
ENSG00000143434	1.87	2.02	1.90	1.65	2.06	1.57	0.142624667246532	2.58131612250575	0.37700577327047	0.746613379643641	1:151131684-151146664:-	SEMA6C	8;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation	SEMA6; semaphorin 6; K06842	semaphorin 6C [Source:HGNC Symbol%3BAcc:HGNC:10740]
ENSG00000215114	30.06	27.81	29.15	28.36	31.05	32.88	-0.0709702353042099	4.97883550927068	0.377368000218602	0.74721151486896	8:58411263-58451501:+	UBXN2B	14;GO:0000045,biological_process autophagosome assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007030,biological_process Golgi organization;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0031468,biological_process nuclear envelope reassembly;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050790,biological_process regulation of catalytic activity;GO:0061025,biological_process membrane fusion	NA	UBX domain protein 2B [Source:HGNC Symbol%3BAcc:HGNC:27035]
ENSG00000115216	92.56	90.29	88.47	87.65	90.04	85.73	0.0545342824788984	7.18408967103728	0.377557883314558	0.747260441742526	2:27427789-27442259:+	NRBP1	17;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005938,cellular_component cell cortex;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0035556,biological_process intracellular signal transduction;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection	NA	nuclear receptor binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7993]
ENSG00000122218	105.57	110.29	101.46	102.87	102.70	102.81	0.0526059145423124	8.59288651290087	0.377580809958677	0.747260441742526	1:160289272-160343400:-	COPA	24;GO:0000139,cellular_component Golgi membrane;GO:0005179,molecular_function hormone activity;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030157,biological_process pancreatic juice secretion;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0070062,cellular_component extracellular exosome	NA	coatomer protein complex subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:2230]
ENSG00000176542	2.55	2.42	2.60	2.80	2.55	2.74	-0.0825801796619498	4.1531094583404	0.37767957821339	0.747260441742526	3:113648384-113696646:-	USF3	7;GO:0000139,cellular_component Golgi membrane;GO:0003677,molecular_function DNA binding;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0006491,biological_process N-glycan processing;GO:0046983,molecular_function protein dimerization activity	NA	upstream transcription factor family member 3 [Source:HGNC Symbol%3BAcc:HGNC:30494]
ENSG00000051825	10.14	11.21	9.70	10.87	11.14	10.75	-0.0705227647394687	5.28608261842575	0.377691756411225	0.747260441742526	12:123152319-123244014:-	MPHOSPH9	6;GO:0000139,cellular_component Golgi membrane;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0016020,cellular_component membrane	NA	M-phase phosphoprotein 9 [Source:HGNC Symbol%3BAcc:HGNC:7215]
ENSG00000067533	19.53	22.14	21.75	22.66	21.96	23.02	-0.0867563507349758	4.21955035894354	0.377693709134988	0.747260441742526	1:218285286-218337983:+	RRP15	4;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000470,biological_process maturation of LSU-rRNA;GO:0006364,biological_process rRNA processing;GO:0030687,cellular_component preribosome, large subunit precursor	NA	ribosomal RNA processing 15 homolog [Source:HGNC Symbol%3BAcc:HGNC:24255]
ENSG00000151229	5.60	6.22	4.79	5.37	4.94	5.11	0.109782605340954	3.41741352616907	0.377819045741132	0.747389293192777	12:39755020-40106089:-	SLC2A13	16;GO:0005215,molecular_function transporter activity;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005366,molecular_function myo-inositol:proton symporter activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015798,biological_process myo-inositol transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0035428,biological_process hexose transmembrane transport;GO:0046323,biological_process glucose import;GO:0055085,biological_process transmembrane transport;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 2 member 13 [Source:HGNC Symbol%3BAcc:HGNC:15956]
ENSG00000100473	2.89	3.85	2.43	2.85	3.82	3.66	-0.179209438743933	2.56629640490979	0.377905485032949	0.747441170445188	14:30874513-30895065:+	COCH	10;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0007605,biological_process sensory perception of sound;GO:0008360,biological_process regulation of cell shape;GO:0031012,cellular_component extracellular matrix;GO:0042742,biological_process defense response to bacterium;GO:0045089,biological_process positive regulation of innate immune response;GO:0070062,cellular_component extracellular exosome	NA	cochlin [Source:HGNC Symbol%3BAcc:HGNC:2180]
ENSG00000160570	15.45	12.89	15.59	12.64	15.76	12.86	0.111724251945482	3.84825190441166	0.37804676374532	0.747501231518598	19:42198597-42220140:-	DEDD2	17;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0006915,biological_process apoptotic process;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0016075,biological_process rRNA catabolic process;GO:0019725,biological_process cellular homeostasis;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030262,biological_process apoptotic nuclear changes;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	NA	death effector domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24450]
ENSG00000116954	43.54	46.23	50.11	45.04	46.32	43.53	0.0645320027316029	5.78097572444317	0.378150156989438	0.747501231518598	1:38838197-38859823:-	RRAGC	30;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007050,biological_process cell cycle arrest;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008380,biological_process RNA splicing;GO:0010506,biological_process regulation of autophagy;GO:0016049,biological_process cell growth;GO:0016241,biological_process regulation of macroautophagy;GO:0019003,molecular_function GDP binding;GO:0032006,biological_process regulation of TOR signaling;GO:0032008,biological_process positive regulation of TOR signaling;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034448,cellular_component EGO complex;GO:0034613,biological_process cellular protein localization;GO:0043200,biological_process response to amino acid;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046982,molecular_function protein heterodimerization activity;GO:0051020,molecular_function GTPase binding;GO:0071230,biological_process cellular response to amino acid stimulus;GO:1903432,biological_process regulation of TORC1 signaling;GO:1990131,cellular_component Gtr1-Gtr2 GTPase complex	RRAGC_D; Ras-related GTP-binding protein C/D; K16186	Ras related GTP binding C [Source:HGNC Symbol%3BAcc:HGNC:19902]
ENSG00000145491	3.38	2.77	3.63	1.84	3.41	3.06	0.257524682504828	1.16439446564676	0.378233053377665	0.747501231518598	5:10441523-10472029:+	ROPN1L	4;GO:0003351,biological_process epithelial cilium movement;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0031514,cellular_component motile cilium	NA	rhophilin associated tail protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:24060]
ENSG00000149273	1417.68	1303.37	1342.37	1479.30	1313.24	1474.25	-0.0586069468699639	10.0817825814065	0.378257809245783	0.747501231518598	11:75399485-75422280:+	RPS3	92;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0002181,biological_process cytoplasmic translation;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005844,cellular_component polysome;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0008017,molecular_function microtubule binding;GO:0008134,molecular_function transcription factor binding;GO:0010628,biological_process positive regulation of gene expression;GO:0015631,molecular_function tubulin binding;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0017148,biological_process negative regulation of translation;GO:0019083,biological_process viral transcription;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030544,molecular_function Hsp70 protein binding;GO:0031012,cellular_component extracellular matrix;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032079,biological_process positive regulation of endodeoxyribonuclease activity;GO:0032357,molecular_function oxidized purine DNA binding;GO:0032358,molecular_function oxidized pyrimidine DNA binding;GO:0032403,molecular_function protein complex binding;GO:0032587,cellular_component ruffle membrane;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042981,biological_process regulation of apoptotic process;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0044390,molecular_function ubiquitin-like protein conjugating enzyme binding;GO:0045738,biological_process negative regulation of DNA repair;GO:0045739,biological_process positive regulation of DNA repair;GO:0050862,biological_process positive regulation of T cell receptor signaling pathway;GO:0051018,molecular_function protein kinase A binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051879,molecular_function Hsp90 protein binding;GO:0061481,biological_process response to TNF agonist;GO:0070062,cellular_component extracellular exosome;GO:0070181,molecular_function small ribosomal subunit rRNA binding;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071159,cellular_component NF-kappaB complex;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0072686,cellular_component mitotic spindle;GO:0097100,molecular_function supercoiled DNA binding;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1902231,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1902546,biological_process positive regulation of DNA N-glycosylase activity;GO:1905053,biological_process positive regulation of base-excision repair;GO:2001235,biological_process positive regulation of apoptotic signaling pathway;GO:2001272,biological_process positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	RP-S3e, RPS3; small subunit ribosomal protein S3e; K02985	ribosomal protein S3 [Source:HGNC Symbol%3BAcc:HGNC:10420]
ENSG00000123388	0.81	0.84	0.97	1.39	1.14	0.81	-0.318939322541038	0.355462997183894	0.378400825680976	0.747501231518598	12:53973125-53977643:+	HOXC11	20;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0001656,biological_process metanephros development;GO:0001759,biological_process organ induction;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007492,biological_process endoderm development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009954,biological_process proximal/distal pattern formation;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060272,biological_process embryonic skeletal joint morphogenesis	NA	homeobox C11 [Source:HGNC Symbol%3BAcc:HGNC:5123]
ENSG00000105290	1.61	1.36	2.06	1.74	2.15	1.86	-0.168522758196775	1.99056967352105	0.378464200277403	0.747501231518598	19:35867898-35879791:+	APLP1	22;GO:0005515,molecular_function protein binding;GO:0005604,cellular_component basement membrane;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0007155,biological_process cell adhesion;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0008201,molecular_function heparin binding;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030818,biological_process negative regulation of cAMP biosynthetic process;GO:0031694,molecular_function alpha-2A adrenergic receptor binding;GO:0031695,molecular_function alpha-2B adrenergic receptor binding;GO:0031696,molecular_function alpha-2C adrenergic receptor binding;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0046914,molecular_function transition metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071874,biological_process cellular response to norepinephrine stimulus	NA	amyloid beta precursor like protein 1 [Source:HGNC Symbol%3BAcc:HGNC:597]
ENSG00000163938	88.65	87.77	85.35	85.15	82.86	86.26	0.0534229366459977	7.15468430506165	0.378539008952003	0.747501231518598	3:52681155-52694492:+	GNL3	21;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0017145,biological_process stem cell division;GO:0019827,biological_process stem cell population maintenance;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0042127,biological_process regulation of cell proliferation;GO:0042254,biological_process ribosome biogenesis;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1904816,biological_process positive regulation of protein localization to chromosome, telomeric region	NUG1, GNL3; nuclear GTP-binding protein; K14538	G protein nucleolar 3 [Source:HGNC Symbol%3BAcc:HGNC:29931]
ENSG00000141441	1.40	1.43	1.35	1.40	1.93	1.45	-0.180098142282384	2.05053409597911	0.378582693007973	0.747501231518598	18:32124876-32470484:-	GAREM1	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0051781,biological_process positive regulation of cell division;GO:0070064,molecular_function proline-rich region binding;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071364,biological_process cellular response to epidermal growth factor stimulus	NA	GRB2 associated regulator of MAPK1 subtype 1 [Source:HGNC Symbol%3BAcc:HGNC:26136]
ENSG00000196372	11.40	11.09	11.89	9.40	12.25	10.35	0.118876694368505	3.23287748519461	0.378597628239103	0.747501231518598	10:5638866-5666595:-	ASB13	5;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	ankyrin repeat and SOCS box containing 13 [Source:HGNC Symbol%3BAcc:HGNC:19765]
ENSG00000153015	14.60	14.62	14.89	16.30	14.41	16.14	-0.0758937463579806	4.62991397774931	0.378620357702895	0.747501231518598	5:64768929-65018763:+	CWC27	8;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006457,biological_process protein folding;GO:0016853,molecular_function isomerase activity;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	CWC27 spliceosome associated protein homolog [Source:HGNC Symbol%3BAcc:HGNC:10664]
ENSG00000143631	2.03	2.13	2.25	2.22	2.38	2.20	-0.0736043688724971	4.75600491903193	0.378635219054061	0.747501231518598	1:152302174-152325203:-	FLG	18;GO:0001533,cellular_component cornified envelope;GO:0005198,molecular_function structural molecule activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0007275,biological_process multicellular organism development;GO:0018149,biological_process peptide cross-linking;GO:0030216,biological_process keratinocyte differentiation;GO:0030280,molecular_function structural constituent of epidermis;GO:0036457,cellular_component keratohyalin granule;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0046914,molecular_function transition metal ion binding;GO:0061436,biological_process establishment of skin barrier;GO:0070268,biological_process cornification;GO:0098773,biological_process skin epidermis development	NA	filaggrin [Source:HGNC Symbol%3BAcc:HGNC:3748]
ENSG00000187498	46.34	46.81	45.46	46.51	52.84	46.34	-0.0601464466448555	7.89925559070704	0.378716472091188	0.747501231518598	13:110148962-110307149:-	COL4A1	25;GO:0001525,biological_process angiogenesis;GO:0001569,biological_process patterning of blood vessels;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005587,cellular_component collagen type IV trimer;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007420,biological_process brain development;GO:0007528,biological_process neuromuscular junction development;GO:0030023,molecular_function extracellular matrix constituent conferring elasticity;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0031012,cellular_component extracellular matrix;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0048407,molecular_function platelet-derived growth factor binding;GO:0048514,biological_process blood vessel morphogenesis;GO:0061304,biological_process retinal blood vessel morphogenesis;GO:0061333,biological_process renal tubule morphogenesis;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071711,biological_process basement membrane organization	COL4A; collagen, type IV, alpha; K06237	collagen type IV alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2202]
ENSG00000274180	5.21	2.82	4.56	6.18	4.70	4.77	-0.263702017106755	0.825341636448167	0.378774367248197	0.747501231518598	17:21238869-21253410:-	NATD1	1;GO:0005515,molecular_function protein binding	NA	N-acetyltransferase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30770]
ENSG00000184788	3.25	4.03	3.25	3.16	2.62	3.74	0.141921718520675	2.82558526841558	0.378808572945479	0.747501231518598	X:85092286-85109048:-	SATL1	8;GO:0004145,molecular_function diamine N-acetyltransferase activity;GO:0005829,cellular_component cytosol;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019809,molecular_function spermidine binding;GO:0032918,biological_process spermidine acetylation;GO:0046208,biological_process spermine catabolic process	NA	spermidine/spermine N1-acetyl transferase like 1 [Source:HGNC Symbol%3BAcc:HGNC:27992]
ENSG00000142856	31.75	36.72	31.23	36.33	32.07	38.18	-0.0926773597989091	4.54256565260955	0.378926518277941	0.747501231518598	1:63440769-63593721:-	ITGB3BP	22;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0043065,biological_process positive regulation of apoptotic process;GO:0051301,biological_process cell division	NA	integrin subunit beta 3 binding protein [Source:HGNC Symbol%3BAcc:HGNC:6157]
ENSG00000162971	12.26	11.43	12.54	14.26	12.68	12.35	-0.0998010539497093	3.5940638479891	0.378955404089332	0.747501231518598	2:199929974-199955736:-	TYW5	12;GO:0000049,molecular_function tRNA binding;GO:0005506,molecular_function iron ion binding;GO:0005737,cellular_component cytoplasm;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0016491,molecular_function oxidoreductase activity;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0031591,biological_process wybutosine biosynthetic process;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	tRNA-yW synthesizing protein 5 [Source:HGNC Symbol%3BAcc:HGNC:26754]
ENSG00000242715	2.48	1.57	1.72	2.19	1.33	1.24	0.312892852715397	0.730327776638027	0.379031462020542	0.747501231518598	13:36222007-36297840:-	CCDC169	NA	NA	coiled-coil domain containing 169 [Source:HGNC Symbol%3BAcc:HGNC:34361]
ENSG00000165282	18.96	19.66	19.28	18.63	19.20	18.30	0.0557563882300256	5.95995203723581	0.37907320287685	0.747501231518598	9:35088687-35096601:-	PIGO	10;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0051377,molecular_function mannose-ethanolamine phosphotransferase activity	PIGO; GPI ethanolamine phosphate transferase 3 subunit O [EC:2.7.-.-]; K05288	phosphatidylinositol glycan anchor biosynthesis class O [Source:HGNC Symbol%3BAcc:HGNC:23215]
ENSG00000092871	5.90	5.97	7.03	5.57	6.48	9.43	-0.173207135072542	2.91149745405706	0.379080017111865	0.747501231518598	17:35005989-35089319:-	RFFL	29;GO:0002020,molecular_function protease binding;GO:0002039,molecular_function p53 binding;GO:0002947,cellular_component tumor necrosis factor receptor superfamily complex;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006915,biological_process apoptotic process;GO:0010008,cellular_component endosome membrane;GO:0010762,biological_process regulation of fibroblast migration;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032006,biological_process regulation of TOR signaling;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0055038,cellular_component recycling endosome membrane;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1901797,biological_process negative regulation of signal transduction by p53 class mediator;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001271,biological_process negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	NA	ring finger and FYVE like domain containing E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:24821]
ENSG00000163704	0.67	1.17	1.29	0.96	0.85	0.86	0.226003054310532	1.61171532318879	0.379207662910321	0.747551089388438	3:9945541-9952394:-	PRRT3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	proline rich transmembrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:26591]
ENSG00000106153	524.16	524.87	506.92	535.18	557.52	533.83	-0.0523862036528877	7.91033621216547	0.379239382061565	0.747551089388438	7:56101568-56106576:-	CHCHD2	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006351,biological_process transcription, DNA-templated;GO:0007005,biological_process mitochondrion organization;GO:0008134,molecular_function transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1900037,biological_process regulation of cellular response to hypoxia	NA	coiled-coil-helix-coiled-coil-helix domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:21645]
ENSG00000153832	7.35	6.91	6.62	6.73	8.96	7.94	-0.164667938714661	2.12724459716783	0.379285971237282	0.747551089388438	2:229922301-230013109:+	FBXO36	NA	NA	F-box protein 36 [Source:HGNC Symbol%3BAcc:HGNC:27020]
ENSG00000108344	84.40	82.87	82.76	89.48	88.21	84.12	-0.0543726849183704	7.14484244433386	0.37939725806862	0.747651716844862	17:39980796-39997960:+	PSMD3	42;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0030234,molecular_function enzyme regulator activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042176,biological_process regulation of protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050790,biological_process regulation of catalytic activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD3, RPN3; 26S proteasome regulatory subunit N3; K03033	proteasome 26S subunit%2C non-ATPase 3 [Source:HGNC Symbol%3BAcc:HGNC:9560]
ENSG00000122335	6.80	7.66	7.48	7.43	6.40	6.84	0.0924897501094941	3.90857846824338	0.379647305662373	0.748025715109054	6:158109514-158168270:-	SERAC1	8;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0006629,biological_process lipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization	NA	serine active site containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21061]
ENSG00000183828	13.72	10.38	11.99	11.47	13.27	15.10	-0.122411752280873	3.42139928597569	0.379742019218287	0.748093585868369	14:105172937-105181323:-	NUDT14	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008768,molecular_function UDP-sugar diphosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	nudix hydrolase 14 [Source:HGNC Symbol%3BAcc:HGNC:20141]
ENSG00000147996	13.13	11.15	12.31	14.21	12.21	12.96	-0.0870661678136685	4.04347306105513	0.380121323521559	0.748721991252478	9:65668804-65734041:+	CBWD5	2;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding	NA	COBW domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:24584]
ENSG00000121851	53.67	45.74	48.28	51.52	50.68	54.51	-0.0691439465649838	5.0625569572542	0.38023566511053	0.748801432575216	1:145964701-145978848:+	POLR3GL	8;GO:0000790,cellular_component nuclear chromatin;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0032481,biological_process positive regulation of type I interferon production	RPC7, POLR3G; DNA-directed RNA polymerase III subunit RPC7; K03024	RNA polymerase III subunit G like [Source:HGNC Symbol%3BAcc:HGNC:28466]
ENSG00000140367	33.23	27.79	30.05	31.79	31.49	33.19	-0.0663928477870852	5.3381037715891	0.380282303307352	0.748801432575216	15:75843284-75901078:+	UBE2Q2	8;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0070936,biological_process protein K48-linked ubiquitination	UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]; K10582	ubiquitin conjugating enzyme E2 Q2 [Source:HGNC Symbol%3BAcc:HGNC:19248]
ENSG00000141378	29.56	32.39	32.03	35.63	31.46	33.47	-0.0898437698852719	4.14268182041638	0.380460341166176	0.74903318237839	17:59674635-59707626:-	PTRH2	11;GO:0004045,molecular_function aminoacyl-tRNA hydrolase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:2000210,biological_process positive regulation of anoikis;GO:2000811,biological_process negative regulation of anoikis	NA	peptidyl-tRNA hydrolase 2 [Source:HGNC Symbol%3BAcc:HGNC:24265]
ENSG00000221821	13.05	10.09	8.50	9.39	11.76	6.03	0.241519528685963	1.64028411298031	0.380635620333856	0.749259428354608	6:42890264-42890816:-	C6orf226	1;GO:0005515,molecular_function protein binding	NA	chromosome 6 open reading frame 226 [Source:HGNC Symbol%3BAcc:HGNC:34431]
ENSG00000135365	21.53	18.38	22.01	20.12	19.05	20.41	0.0721187146805619	5.53510031742911	0.380879276593243	0.749620177636266	11:45929322-46121178:-	PHF21A	17;GO:0000118,cellular_component histone deacetylase complex;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007596,biological_process blood coagulation;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding;GO:1990391,cellular_component DNA repair complex	NA	PHD finger protein 21A [Source:HGNC Symbol%3BAcc:HGNC:24156]
ENSG00000174720	33.15	34.48	32.38	32.98	37.82	34.44	-0.0631047036355501	6.03130712757679	0.381319004654151	0.749798695507685	4:112636963-112657592:+	LARP7	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	La ribonucleoprotein domain family member 7 [Source:HGNC Symbol%3BAcc:HGNC:24912]
ENSG00000105672	0.83	0.88	1.36	0.75	1.08	0.65	0.331108699748685	0.326781831055824	0.381327613668682	0.749798695507685	19:35641744-35644871:+	ETV2	25;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0001707,biological_process mesoderm formation;GO:0001824,biological_process blastocyst development;GO:0001890,biological_process placenta development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007219,biological_process Notch signaling pathway;GO:0010628,biological_process positive regulation of gene expression;GO:0016055,biological_process Wnt signaling pathway;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045603,biological_process positive regulation of endothelial cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048514,biological_process blood vessel morphogenesis;GO:0060803,biological_process BMP signaling pathway involved in mesodermal cell fate specification;GO:2000382,biological_process positive regulation of mesoderm development	NA	ETS variant 2 [Source:HGNC Symbol%3BAcc:HGNC:3491]
ENSG00000180667	4.90	6.02	5.38	4.92	5.61	4.24	0.146288811175424	2.5324090834605	0.38138655485672	0.749798695507685	1:207043848-207052980:-	YOD1	28;GO:0003676,molecular_function nucleic acid binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006986,biological_process response to unfolded protein;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016236,biological_process macroautophagy;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035523,biological_process protein K29-linked deubiquitination;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol;GO:1904265,molecular_function ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol;GO:1990167,biological_process protein K27-linked deubiquitination;GO:1990168,biological_process protein K33-linked deubiquitination;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	OTU1, YOD1; ubiquitin thioesterase OTU1 [EC:3.1.2.-]; K13719	YOD1 deubiquitinase [Source:HGNC Symbol%3BAcc:HGNC:25035]
ENSG00000233927	333.34	240.99	255.65	305.64	261.97	328.15	-0.0957093611903512	5.90389014309181	0.381454196000743	0.749798695507685	19:8321157-8323340:+	RPS28	21;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042254,biological_process ribosome biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein S28 [Source:HGNC Symbol%3BAcc:HGNC:10418]
ENSG00000154642	7.93	5.58	9.09	8.82	7.92	8.60	-0.135810006418671	2.8762214906847	0.381467488640907	0.749798695507685	21:17788966-17819386:-	C21orf91	NA	NA	chromosome 21 open reading frame 91 [Source:HGNC Symbol%3BAcc:HGNC:16459]
ENSG00000171291	5.80	6.64	7.08	5.95	6.59	5.64	0.11329043815823	3.25345123936466	0.381529329946735	0.749798695507685	19:11848725-11883750:+	ZNF439	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 439 [Source:HGNC Symbol%3BAcc:HGNC:20873]
ENSG00000167460	211.99	206.12	204.22	203.75	199.75	202.28	0.0507397208740486	8.00794600665162	0.381532303942197	0.749798695507685	19:16067020-16103005:+	TPM4	27;GO:0001649,biological_process osteoblast differentiation;GO:0001725,cellular_component stress fiber;GO:0002102,cellular_component podosome;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005862,cellular_component muscle thin filament tropomyosin;GO:0005884,cellular_component actin filament;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0006936,biological_process muscle contraction;GO:0007015,biological_process actin filament organization;GO:0008307,molecular_function structural constituent of muscle;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030049,biological_process muscle filament sliding;GO:0030863,cellular_component cortical cytoskeleton;GO:0031941,cellular_component filamentous actin;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	NA	tropomyosin 4 [Source:HGNC Symbol%3BAcc:HGNC:12013]
ENSG00000100650	346.24	345.55	359.14	329.97	336.16	355.70	0.052444023194794	8.23651655220483	0.381575927081711	0.749798695507685	14:69726899-69772005:+	SRSF5	23;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001889,biological_process liver development;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0032868,biological_process response to insulin;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033120,biological_process positive regulation of RNA splicing;GO:0043422,molecular_function protein kinase B binding;GO:0051726,biological_process regulation of cell cycle;GO:0097421,biological_process liver regeneration	SFRS4_5_6; splicing factor, arginine/serine-rich 4/5/6; K12893	serine and arginine rich splicing factor 5 [Source:HGNC Symbol%3BAcc:HGNC:10787]
ENSG00000107020	60.22	59.38	53.24	64.69	57.44	61.55	-0.0780518374557593	4.72086834902422	0.381636529504591	0.749798695507685	9:5357972-5437878:-	PLGRKT	9;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0010756,biological_process positive regulation of plasminogen activation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	plasminogen receptor with a C-terminal lysine [Source:HGNC Symbol%3BAcc:HGNC:23633]
ENSG00000254462	37.26	31.24	31.44	41.43	39.27	29.81	-0.126128996233771	3.46145508774608	0.381683092353542	0.749798695507685	11:57712604-57791586:+	TMX2-CTNND1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	TMX2-CTNND1 readthrough (NMD candidate) [Source:HGNC Symbol%3BAcc:HGNC:41992]
ENSG00000139641	54.31	55.99	54.86	57.80	56.78	57.99	-0.0519822761535006	7.55748228814284	0.381729436409814	0.749798695507685	12:56118249-56144671:+	ESYT1	14;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044232,cellular_component organelle membrane contact site;GO:0046872,molecular_function metal ion binding	NA	extended synaptotagmin 1 [Source:HGNC Symbol%3BAcc:HGNC:29534]
ENSG00000154920	8.48	8.47	8.00	10.36	7.72	8.97	-0.106324976286974	3.93762628789082	0.381730885694004	0.749798695507685	17:50373219-50381483:+	EME1	24;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005720,cellular_component nuclear heterochromatin;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0031297,biological_process replication fork processing;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0036297,biological_process interstrand cross-link repair;GO:0046872,molecular_function metal ion binding;GO:0048476,cellular_component Holliday junction resolvase complex;GO:0072429,biological_process response to intra-S DNA damage checkpoint signaling;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]; K10882	essential meiotic structure-specific endonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:24965]
ENSG00000132109	19.97	15.63	23.24	24.01	19.00	21.12	-0.106182639659209	4.8830272751225	0.381755236897492	0.749798695507685	11:4384896-4393696:-	TRIM21	37;GO:0000209,biological_process protein polyubiquitination;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006513,biological_process protein monoubiquitination;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0010508,biological_process positive regulation of autophagy;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031648,biological_process protein destabilization;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032479,biological_process regulation of type I interferon production;GO:0032897,biological_process negative regulation of viral transcription;GO:0034341,biological_process response to interferon-gamma;GO:0042802,molecular_function identical protein binding;GO:0045087,biological_process innate immune response;GO:0045787,biological_process positive regulation of cell cycle;GO:0046598,biological_process positive regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051865,biological_process protein autoubiquitination;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070206,biological_process protein trimerization;GO:0090086,biological_process negative regulation of protein deubiquitination;GO:1902187,biological_process negative regulation of viral release from host cell	TRIM21, SSA1; tripartite motif-containing protein 21 [EC:2.3.2.27]; K10651	tripartite motif containing 21 [Source:HGNC Symbol%3BAcc:HGNC:11312]
ENSG00000171843	33.02	30.40	34.80	35.75	33.28	34.48	-0.0606292824469975	5.84904504906535	0.381833065954813	0.749832913731544	9:20341664-20622543:-	MLLT3	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0007379,biological_process segment specification;GO:0008023,cellular_component transcription elongation factor complex;GO:0009952,biological_process anterior/posterior pattern specification;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000096,biological_process positive regulation of Wnt signaling pathway, planar cell polarity pathway	MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3; K15187	MLLT3%2C super elongation complex subunit [Source:HGNC Symbol%3BAcc:HGNC:7136]
ENSG00000160785	12.06	13.36	12.11	12.63	11.78	10.70	0.103334356943667	3.56226443196578	0.381948254783405	0.749940475581526	1:156193931-156212796:+	SLC25A44	9;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 44 [Source:HGNC Symbol%3BAcc:HGNC:29036]
ENSG00000140320	7.45	7.43	7.05	6.27	7.78	6.67	0.0936578636206312	4.06817099128232	0.382084145606283	0.750041435081826	15:40439720-40468242:+	BAHD1	14;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005677,cellular_component chromatin silencing complex;GO:0005694,cellular_component chromosome;GO:0006342,biological_process chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0031507,biological_process heterochromatin assembly;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	bromo adjacent homology domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29153]
ENSG00000146859	33.47	33.58	35.28	32.38	33.34	32.05	0.078677315676621	4.22231546728306	0.382170115407649	0.750041435081826	7:135148071-135166215:+	TMEM140	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 140 [Source:HGNC Symbol%3BAcc:HGNC:21870]
ENSG00000266472	135.57	114.61	116.46	135.97	125.82	127.97	-0.0719143094877904	5.05016013751324	0.382180945532309	0.750041435081826	1:150293719-150308979:+	MRPS21	5;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation	RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21; K02970	mitochondrial ribosomal protein S21 [Source:HGNC Symbol%3BAcc:HGNC:14046]
ENSG00000205060	8.23	9.15	7.70	8.20	8.68	10.55	-0.128603330910301	3.17292552593384	0.382433388153287	0.750418218012449	7:134289331-134317051:-	SLC35B4	19;GO:0000139,cellular_component Golgi membrane;GO:0005457,molecular_function GDP-fucose transmembrane transporter activity;GO:0005462,molecular_function UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005464,molecular_function UDP-xylose transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015783,biological_process GDP-fucose transport;GO:0015788,biological_process UDP-N-acetylglucosamine transport;GO:0015790,biological_process UDP-xylose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0055085,biological_process transmembrane transport;GO:1990569,biological_process UDP-N-acetylglucosamine transmembrane transport	NA	solute carrier family 35 member B4 [Source:HGNC Symbol%3BAcc:HGNC:20584]
ENSG00000239306	16.55	15.61	15.83	16.84	16.52	17.21	-0.0623114875831281	5.13381061340214	0.382508518414093	0.750447011075412	11:66616581-66627347:+	RBM14	26;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009725,biological_process response to hormone;GO:0016575,biological_process histone deacetylation;GO:0016592,cellular_component mediator complex;GO:0016607,cellular_component nuclear speck;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030674,molecular_function protein binding, bridging;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046600,biological_process negative regulation of centriole replication;GO:0060395,biological_process SMAD protein signal transduction;GO:0098534,biological_process centriole assembly	NA	RNA binding motif protein 14 [Source:HGNC Symbol%3BAcc:HGNC:14219]
ENSG00000125520	105.48	107.09	110.88	113.57	109.81	115.26	-0.0544600225871429	7.00407707877311	0.382575986778737	0.750460765468467	20:63739860-63743505:+	SLC2A4RG	11;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding	NA	SLC2A4 regulator [Source:HGNC Symbol%3BAcc:HGNC:15930]
ENSG00000106330	44.12	46.56	46.39	44.01	45.33	42.53	0.0662429092332431	4.99035875062548	0.382825136832609	0.750703663537797	7:100612101-100615384:+	MOSPD3	4;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	motile sperm domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25078]
ENSG00000235106	21.40	23.93	22.77	20.42	26.13	27.25	-0.109355595405569	3.90544393285817	0.382855527776392	0.750703663537797	9:134025438-134034666:+	LINC00094	NA	NA	long intergenic non-protein coding RNA 94 [Source:HGNC Symbol%3BAcc:HGNC:24742]
ENSG00000188483	28.09	25.70	26.36	28.66	26.34	29.82	-0.0681796948561178	5.06797510419847	0.382931799751675	0.750703663537797	9:129175551-129178262:-	IER5L	NA	NA	immediate early response 5 like [Source:HGNC Symbol%3BAcc:HGNC:23679]
ENSG00000130508	0.36	0.21	0.19	0.25	0.12	0.25	0.340802646532661	0.266499309516662	0.383015582912828	0.750703663537797	2:1631886-1744852:-	PXDN	19;GO:0001960,biological_process negative regulation of cytokine-mediated signaling pathway;GO:0004601,molecular_function peroxidase activity;GO:0005152,molecular_function interleukin-1 receptor antagonist activity;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0006955,biological_process immune response;GO:0006979,biological_process response to oxidative stress;GO:0016491,molecular_function oxidoreductase activity;GO:0020037,molecular_function heme binding;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	NA	peroxidasin [Source:HGNC Symbol%3BAcc:HGNC:14966]
ENSG00000115159	13.85	11.99	12.34	10.92	11.74	13.67	0.0856448253930659	4.81418930057683	0.383049616482554	0.750703663537797	2:156435289-156613735:+	GPD2	16;GO:0004368,molecular_function glycerol-3-phosphate dehydrogenase activity;GO:0005509,molecular_function calcium ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006072,biological_process glycerol-3-phosphate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006127,biological_process glycerophosphate shuttle;GO:0009331,cellular_component glycerol-3-phosphate dehydrogenase complex;GO:0016491,molecular_function oxidoreductase activity;GO:0019563,biological_process glycerol catabolic process;GO:0035264,biological_process multicellular organism growth;GO:0043010,biological_process camera-type eye development;GO:0046872,molecular_function metal ion binding;GO:0052590,molecular_function sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity;GO:0052591,molecular_function sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]; K00111	glycerol-3-phosphate dehydrogenase 2 [Source:HGNC Symbol%3BAcc:HGNC:4456]
ENSG00000114416	122.14	124.21	131.72	126.89	131.76	137.20	-0.0543641036000462	8.03083141742988	0.383062676617128	0.750703663537797	3:180868140-180982753:+	FXR1	27;GO:0002151,molecular_function G-quadruplex RNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0033592,molecular_function RNA strand annealing activity;GO:0035770,cellular_component ribonucleoprotein granule;GO:0042803,molecular_function protein homodimerization activity;GO:0043034,cellular_component costamere;GO:0043197,cellular_component dendritic spine;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:2000637,biological_process positive regulation of gene silencing by miRNA	FMR; fragile X mental retardation protein; K15516	FMR1 autosomal homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:4023]
ENSG00000112419	1.79	1.59	1.29	1.66	1.50	2.20	-0.193604053259477	1.92492832795632	0.383128195187384	0.750713541730229	6:143536844-143831185:+	PHACTR2	8;GO:0002576,biological_process platelet degranulation;GO:0003779,molecular_function actin binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0031092,cellular_component platelet alpha granule membrane;GO:0043086,biological_process negative regulation of catalytic activity	NA	phosphatase and actin regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:20956]
ENSG00000156599	39.97	42.95	40.21	41.29	44.34	43.53	-0.059019804491918	6.49783540204677	0.383194751871866	0.750725450597455	11:57667746-57701187:+	ZDHHC5	10;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0030425,cellular_component dendrite	NA	zinc finger DHHC-type containing 5 [Source:HGNC Symbol%3BAcc:HGNC:18472]
ENSG00000269713	8.65	8.26	10.69	9.77	7.74	8.52	0.0989548468967671	4.9069159115665	0.383405775939053	0.751020340339509	1:149054026-149103561:-	NBPF9	2;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	NBPF member 9 [Source:HGNC Symbol%3BAcc:HGNC:31991]
ENSG00000155252	3.83	2.93	1.79	3.39	3.22	3.38	-0.209824933396751	2.20410274268824	0.383568425574226	0.751220395495876	10:97640685-97676434:+	PI4K2A	35;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004430,molecular_function 1-phosphatidylinositol 4-kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007030,biological_process Golgi organization;GO:0007032,biological_process endosome organization;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0031083,cellular_component BLOC-1 complex;GO:0031224,cellular_component intrinsic component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035651,molecular_function AP-3 adaptor complex binding;GO:0035838,cellular_component growing cell tip;GO:0042734,cellular_component presynaptic membrane;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0044231,cellular_component host cell presynaptic membrane;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0046854,biological_process phosphatidylinositol phosphorylation	PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]; K13711	phosphatidylinositol 4-kinase type 2 alpha [Source:HGNC Symbol%3BAcc:HGNC:30031]
ENSG00000145945	4.56	5.00	3.32	3.61	3.81	3.97	0.17485011875702	2.02501326820282	0.383633025756998	0.751228387556651	6:3849385-3851317:+	FAM50B	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0045171,cellular_component intercellular bridge	NA	family with sequence similarity 50 member B [Source:HGNC Symbol%3BAcc:HGNC:18789]
ENSG00000147130	37.39	39.44	39.29	35.45	39.91	37.07	0.0579014434813775	7.29997864906334	0.383802559676275	0.751354683091847	X:71239623-71255146:-	ZMYM3	11;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0022604,biological_process regulation of cell morphogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger MYM-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:13054]
ENSG00000006607	5.73	6.48	5.98	6.02	6.44	6.84	-0.0797243765570656	4.72336352147254	0.38381858096233	0.751354683091847	2:241356242-241494841:+	FARP2	18;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007155,biological_process cell adhesion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016322,biological_process neuron remodeling;GO:0016601,biological_process Rac protein signal transduction;GO:0022405,biological_process hair cycle process;GO:0030316,biological_process osteoclast differentiation;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0033623,biological_process regulation of integrin activation;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:0071800,biological_process podosome assembly	FARP2, FRG; FERM, RhoGEF and pleckstrin domain protein 2; K06082	FERM%2C ARH/RhoGEF and pleckstrin domain protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16460]
ENSG00000066405	5.07	4.38	6.75	4.93	4.76	4.98	0.168358273363314	2.41717985630286	0.383938802992002	0.751464633368106	3:137998734-138033655:+	CLDN18	14;GO:0005198,molecular_function structural molecule activity;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016338,biological_process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030054,cellular_component cell junction;GO:0042802,molecular_function identical protein binding;GO:0045471,biological_process response to ethanol;GO:0045779,biological_process negative regulation of bone resorption;GO:0048565,biological_process digestive tract development;GO:0071847,biological_process TNFSF11-mediated signaling pathway;GO:1900181,biological_process negative regulation of protein localization to nucleus;GO:2001205,biological_process negative regulation of osteoclast development	CLDN; claudin; K06087	claudin 18 [Source:HGNC Symbol%3BAcc:HGNC:2039]
ENSG00000170855	32.22	39.82	39.06	43.68	35.26	42.56	-0.126342411371808	3.16742121150462	0.384001496510029	0.751464633368106	12:120443960-120446412:-	TRIAP1	24;GO:0002039,molecular_function p53 binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006915,biological_process apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0015914,biological_process phospholipid transport;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0034644,biological_process cellular response to UV;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097035,biological_process regulation of membrane lipid distribution;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1990050,molecular_function phosphatidic acid transporter activity;GO:2001140,biological_process positive regulation of phospholipid transport	NA	TP53 regulated inhibitor of apoptosis 1 [Source:HGNC Symbol%3BAcc:HGNC:26937]
ENSG00000101004	5.79	5.83	6.41	6.66	5.84	6.70	-0.0780637826397907	4.69627534272868	0.384120684216604	0.751464633368106	20:25452704-25585517:-	NINL	12;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	ninein like [Source:HGNC Symbol%3BAcc:HGNC:29163]
ENSG00000100092	2.93	3.75	3.43	3.95	3.61	3.54	-0.133891316941499	2.94652757604417	0.384185578496358	0.751464633368106	22:37634653-37666932:+	SH3BP1	6;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0043547,biological_process positive regulation of GTPase activity	NA	SH3 domain binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10824]
ENSG00000078618	79.89	80.36	79.82	77.57	74.29	81.53	0.0524188387788101	8.17488607641773	0.38425989886293	0.751464633368106	1:51789190-51878937:-	NRDC	17;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0007528,biological_process neuromuscular junction development;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008283,biological_process cell proliferation;GO:0009986,cellular_component cell surface;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0048408,molecular_function epidermal growth factor binding;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0052548,biological_process regulation of endopeptidase activity	NA	nardilysin convertase [Source:HGNC Symbol%3BAcc:HGNC:7995]
ENSG00000137807	31.60	32.97	29.25	30.37	36.96	31.97	-0.0711680387146278	6.61255165065444	0.384284646161768	0.751464633368106	15:69414245-69448427:+	KIF23	35;GO:0000022,biological_process mitotic spindle elongation;GO:0000166,molecular_function nucleotide binding;GO:0000281,biological_process mitotic cytokinesis;GO:0000910,biological_process cytokinesis;GO:0000915,biological_process actomyosin contractile ring assembly;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005925,cellular_component focal adhesion;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030496,cellular_component midbody;GO:0032467,biological_process positive regulation of cytokinesis;GO:0045171,cellular_component intercellular bridge;GO:0051256,biological_process mitotic spindle midzone assembly;GO:0051301,biological_process cell division;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule;GO:0072686,cellular_component mitotic spindle;GO:0097149,cellular_component centralspindlin complex	KIF23; kinesin family member 23; K17387	kinesin family member 23 [Source:HGNC Symbol%3BAcc:HGNC:6392]
ENSG00000205238	1.29	1.35	1.10	0.62	1.32	1.11	0.293747550961756	0.59244235431328	0.384348044613132	0.751464633368106	7:102551231-102562308:+	SPDYE2	3;GO:0005515,molecular_function protein binding;GO:0019901,molecular_function protein kinase binding;GO:0045859,biological_process regulation of protein kinase activity	NA	speedy/RINGO cell cycle regulator family member E2 [Source:HGNC Symbol%3BAcc:HGNC:33841]
ENSG00000161040	1.31	1.07	0.88	0.75	1.20	0.87	0.226209559473567	1.4722153953279	0.384425869977354	0.751464633368106	7:102813229-103074843:-	FBXL13	4;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 13 [Source:HGNC Symbol%3BAcc:HGNC:21658]
ENSG00000135622	8.56	7.87	8.45	8.12	9.32	9.14	-0.0800659411083802	4.35877481741079	0.384516540049505	0.751464633368106	2:74654227-74683853:+	SEMA4F	16;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030517,biological_process negative regulation of axon extension;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0050919,biological_process negative chemotaxis	SEMA4, CD100; semaphorin 4; K06521	ssemaphorin 4F [Source:HGNC Symbol%3BAcc:HGNC:10734]
ENSG00000182636	8.07	12.40	11.54	12.05	13.47	10.08	-0.149202596351715	3.45241462882881	0.38451767173927	0.751464633368106	15:23685399-23687330:-	NDN	32;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001764,biological_process neuron migration;GO:0003016,biological_process respiratory system process;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0007413,biological_process axonal fasciculation;GO:0007417,biological_process central nervous system development;GO:0007585,biological_process respiratory gaseous exchange;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008347,biological_process glial cell migration;GO:0009791,biological_process post-embryonic development;GO:0019233,biological_process sensory perception of pain;GO:0040008,biological_process regulation of growth;GO:0042995,cellular_component cell projection;GO:0043015,molecular_function gamma-tubulin binding;GO:0043204,cellular_component perikaryon;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0048666,biological_process neuron development;GO:0048675,biological_process axon extension;GO:0048871,biological_process multicellular organismal homeostasis;GO:0071514,biological_process genetic imprinting	NA	necdin%2C MAGE family member [Source:HGNC Symbol%3BAcc:HGNC:7675]
ENSG00000084693	26.53	26.46	25.43	25.53	28.33	28.46	-0.0589690005663057	6.27637667640762	0.384540671163636	0.751464633368106	2:27042363-27070622:+	AGBL5	19;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0015631,molecular_function tubulin binding;GO:0016787,molecular_function hydrolase activity;GO:0030496,cellular_component midbody;GO:0035608,biological_process protein deglutamylation;GO:0035611,biological_process protein branching point deglutamylation;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0072686,cellular_component mitotic spindle	NA	ATP/GTP binding protein like 5 [Source:HGNC Symbol%3BAcc:HGNC:26147]
ENSG00000172500	49.03	50.62	52.75	49.69	51.36	46.23	0.0616782401333523	5.79975716106249	0.384781386016492	0.751816676313979	11:65883740-65888539:-	FIBP	9;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0017134,molecular_function fibroblast growth factor binding;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation	NA	FGF1 intracellular binding protein [Source:HGNC Symbol%3BAcc:HGNC:3705]
ENSG00000090520	40.11	42.00	38.45	39.32	38.20	38.83	0.0599268178090864	5.4108238594469	0.384854381759178	0.751840956999793	3:186567402-186585800:+	DNAJB11	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0016556,biological_process mRNA modification;GO:0032781,biological_process positive regulation of ATPase activity;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0051082,molecular_function unfolded protein binding	DNAJB11; DnaJ homolog subfamily B member 11; K09517	DnaJ heat shock protein family (Hsp40) member B11 [Source:HGNC Symbol%3BAcc:HGNC:14889]
ENSG00000010379	0.43	0.86	1.22	0.71	0.49	0.78	0.334465897621347	0.709031348420933	0.384965338824237	0.751847162598861	12:220620-262873:-	SLC6A13	13;GO:0005215,molecular_function transporter activity;GO:0005328,molecular_function neurotransmitter:sodium symporter activity;GO:0005332,molecular_function gamma-aminobutyric acid:sodium symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0015293,molecular_function symporter activity;GO:0015812,biological_process gamma-aminobutyric acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	NA	solute carrier family 6 member 13 [Source:HGNC Symbol%3BAcc:HGNC:11046]
ENSG00000110921	8.32	11.26	7.56	6.57	9.69	8.38	0.14054039819844	3.60204180730266	0.384978696969174	0.751847162598861	12:109573254-109598117:+	MVK	21;GO:0000166,molecular_function nucleotide binding;GO:0004496,molecular_function mevalonate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016126,biological_process sterol biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019287,biological_process isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0042802,molecular_function identical protein binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0050728,biological_process negative regulation of inflammatory response;GO:0070062,cellular_component extracellular exosome	E2.7.1.36, MVK, mvaK1; mevalonate kinase [EC:2.7.1.36]; K00869	mevalonate kinase [Source:HGNC Symbol%3BAcc:HGNC:7530]
ENSG00000107021	14.60	17.04	17.30	14.60	16.56	15.18	0.0866536846104529	4.26106817761274	0.385165883130096	0.751971719756022	9:128787203-128810432:+	TBC1D13	11;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0043547,biological_process positive regulation of GTPase activity;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 13 [Source:HGNC Symbol%3BAcc:HGNC:25571]
ENSG00000010818	12.48	12.95	12.66	11.82	12.94	12.13	0.0573044886583537	6.52152909786453	0.385252340783853	0.751971719756022	6:142751466-142956698:-	HIVEP2	13;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0046872,molecular_function metal ion binding	NA	human immunodeficiency virus type I enhancer binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4921]
ENSG00000189266	139.44	141.80	135.50	132.72	142.74	127.89	0.0584559272703961	6.32419574321373	0.385254112282512	0.751971719756022	1:23959108-23963462:+	PNRC2	11;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031087,biological_process deadenylation-independent decapping of nuclear-transcribed mRNA	NA	proline rich nuclear receptor coactivator 2 [Source:HGNC Symbol%3BAcc:HGNC:23158]
ENSG00000172728	2.85	3.26	3.02	2.61	2.96	2.69	0.149889873310958	2.10346217133382	0.385284793172344	0.751971719756022	8:33370823-33473422:-	FUT10	23;GO:0000139,cellular_component Golgi membrane;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006457,biological_process protein folding;GO:0006486,biological_process protein glycosylation;GO:0006605,biological_process protein targeting;GO:0007399,biological_process nervous system development;GO:0008417,molecular_function fucosyltransferase activity;GO:0009566,biological_process fertilization;GO:0009790,biological_process embryo development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0030097,biological_process hemopoiesis;GO:0032580,cellular_component Golgi cisterna membrane;GO:0036065,biological_process fucosylation;GO:0042060,biological_process wound healing;GO:0042355,biological_process L-fucose catabolic process;GO:0046920,molecular_function alpha-(1->3)-fucosyltransferase activity;GO:0097150,biological_process neuronal stem cell population maintenance	NA	fucosyltransferase 10 [Source:HGNC Symbol%3BAcc:HGNC:19234]
ENSG00000013364	150.22	156.12	152.19	155.12	161.31	162.21	-0.0503637785678737	8.72257023757622	0.385736025662436	0.752734049135012	16:29820393-29848039:+	MVP	24;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0023057,biological_process negative regulation of signaling;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031953,biological_process negative regulation of protein autophosphorylation;GO:0034774,cellular_component secretory granule lumen;GO:0038127,biological_process ERBB signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051028,biological_process mRNA transport;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	major vault protein [Source:HGNC Symbol%3BAcc:HGNC:7531]
ENSG00000223501	27.82	28.02	29.06	28.76	30.75	29.50	-0.0560340703637242	6.09001898951394	0.385879336661988	0.752895348315822	6:33250271-33272047:-	VPS52	21;GO:0000938,cellular_component GARP complex;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006896,biological_process Golgi to vacuole transport;GO:0007041,biological_process lysosomal transport;GO:0010008,cellular_component endosome membrane;GO:0010668,biological_process ectodermal cell differentiation;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0019905,molecular_function syntaxin binding;GO:0032456,biological_process endocytic recycling;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048611,biological_process embryonic ectodermal digestive tract development;GO:0055037,cellular_component recycling endosome;GO:1990745,cellular_component EARP complex	NA	VPS52%2C GARP complex subunit [Source:HGNC Symbol%3BAcc:HGNC:10518]
ENSG00000119231	9.75	10.11	9.07	10.96	10.14	9.68	-0.0804938207483441	4.51852879806796	0.386133621730861	0.753273086051419	3:196867855-196934714:+	SENP5	15;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006508,biological_process proteolysis;GO:0007049,biological_process cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016925,biological_process protein sumoylation;GO:0016926,biological_process protein desumoylation;GO:0016929,molecular_function SUMO-specific protease activity;GO:0051301,biological_process cell division;GO:0070139,molecular_function SUMO-specific endopeptidase activity	NA	SUMO1/sentrin specific peptidase 5 [Source:HGNC Symbol%3BAcc:HGNC:28407]
ENSG00000173546	0.48	0.51	0.46	0.49	0.38	0.40	0.186258578887616	1.72587465949939	0.386223552424478	0.753330131402427	15:75674321-75712848:-	CSPG4	30;GO:0000187,biological_process activation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0004871,molecular_function signal transducer activity;GO:0005576,cellular_component extracellular region;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0008347,biological_process glial cell migration;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019901,molecular_function protein kinase binding;GO:0030154,biological_process cell differentiation;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030207,biological_process chondroitin sulfate catabolic process;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0031258,cellular_component lamellipodium membrane;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043202,cellular_component lysosomal lumen;GO:0048771,biological_process tissue remodeling;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0070062,cellular_component extracellular exosome	NA	chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol%3BAcc:HGNC:2466]
ENSG00000141577	5.61	6.13	5.27	5.19	5.34	5.61	0.0807944973818049	4.2132011236741	0.386375891407646	0.753459679462596	17:81189592-81222999:-	CEP131	32;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0001669,cellular_component acrosomal vesicle;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010824,biological_process regulation of centrosome duplication;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0030154,biological_process cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032403,molecular_function protein complex binding;GO:0034451,cellular_component centriolar satellite;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0035869,cellular_component ciliary transition zone;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045171,cellular_component intercellular bridge;GO:0071539,biological_process protein localization to centrosome;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 131 [Source:HGNC Symbol%3BAcc:HGNC:29511]
ENSG00000064547	6.44	6.90	9.93	7.54	6.19	7.35	0.157664688689886	2.99134737673553	0.386446768152943	0.753459679462596	19:19623667-19628930:-	LPAR2	15;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007202,biological_process activation of phospholipase C activity;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008289,molecular_function lipid binding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030139,cellular_component endocytic vesicle;GO:0070915,molecular_function lysophosphatidic acid receptor activity	LPAR2, EDG4; lysophosphatidic acid receptor 2; K04291	lysophosphatidic acid receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:3168]
ENSG00000261794	1.53	1.36	2.87	1.62	1.52	1.82	0.24090726917976	1.83548677689923	0.386484613779467	0.753459679462596	15:30604125-30614561:+	GOLGA8H	1;GO:0005794,cellular_component Golgi apparatus	NA	golgin A8 family member H [Source:HGNC Symbol%3BAcc:HGNC:37443]
ENSG00000186298	80.28	86.63	77.84	81.10	78.27	77.40	0.0577001705005297	6.65167236454418	0.386544287140254	0.753459679462596	12:110719679-110742939:-	PPP1CC	46;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003723,molecular_function RNA binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0008022,molecular_function protein C-terminus binding;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030182,biological_process neuron differentiation;GO:0030496,cellular_component midbody;GO:0032154,cellular_component cleavage furrow;GO:0032403,molecular_function protein complex binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0042752,biological_process regulation of circadian rhythm;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043197,cellular_component dendritic spine;GO:0043234,cellular_component protein complex;GO:0046822,biological_process regulation of nucleocytoplasmic transport;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0048511,biological_process rhythmic process;GO:0051301,biological_process cell division;GO:0072357,cellular_component PTW/PP1 phosphatase complex	PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]; K06269	protein phosphatase 1 catalytic subunit gamma [Source:HGNC Symbol%3BAcc:HGNC:9283]
ENSG00000256806	4.79	4.32	3.74	3.17	2.57	4.77	0.290448817657627	0.615901609108559	0.386633608249759	0.753459679462596	17:6651717-6693202:+	C17orf100	NA	NA	chromosome 17 open reading frame 100 [Source:HGNC Symbol%3BAcc:HGNC:34494]
ENSG00000084090	43.44	40.91	38.79	43.02	41.54	45.09	-0.0625762342135835	5.55626416700528	0.386686617385916	0.753459679462596	2:96184858-96208825:-	STARD7	5;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0008289,molecular_function lipid binding;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	StAR related lipid transfer domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:18063]
ENSG00000105447	18.74	19.43	16.83	16.79	18.20	17.50	0.0752319322784117	4.59049284016275	0.386714864888117	0.753459679462596	19:48445772-48457022:+	GRWD1	13;GO:0003682,molecular_function chromatin binding;GO:0003688,molecular_function DNA replication origin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006334,biological_process nucleosome assembly;GO:0006337,biological_process nucleosome disassembly;GO:0042393,molecular_function histone binding;GO:0043234,cellular_component protein complex	NA	glutamate rich WD repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21270]
ENSG00000162517	47.91	46.44	43.02	49.12	49.49	46.22	-0.0645395245750262	5.33084901744127	0.386790257802435	0.753488303531329	1:31629861-31644896:-	PEF1	25;GO:0000139,cellular_component Golgi membrane;GO:0003723,molecular_function RNA binding;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006508,biological_process proteolysis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0014029,biological_process neural crest formation;GO:0014032,biological_process neural crest cell development;GO:0016020,cellular_component membrane;GO:0030127,cellular_component COPII vesicle coat;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048208,biological_process COPII vesicle coating;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051592,biological_process response to calcium ion;GO:0060090,molecular_function binding, bridging;GO:0070062,cellular_component extracellular exosome;GO:1902527,biological_process positive regulation of protein monoubiquitination	NA	penta-EF-hand domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30009]
ENSG00000177981	17.80	15.74	16.36	17.60	18.06	17.72	-0.0800527588361546	4.13315696401449	0.386937222518368	0.753570552352179	12:48147787-48181213:-	ASB8	5;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	ankyrin repeat and SOCS box containing 8 [Source:HGNC Symbol%3BAcc:HGNC:17183]
ENSG00000134371	33.56	32.94	32.99	33.14	36.75	34.61	-0.0585208364081487	5.76434817947545	0.386953895165777	0.753570552352179	1:193122016-193253901:+	CDC73	39;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000993,molecular_function RNA polymerase II core binding;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001558,biological_process regulation of cell growth;GO:0001711,biological_process endodermal cell fate commitment;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006378,biological_process mRNA polyadenylation;GO:0007049,biological_process cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010390,biological_process histone monoubiquitination;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016570,biological_process histone modification;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0019827,biological_process stem cell population maintenance;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0031442,biological_process positive regulation of mRNA 3'-end processing;GO:0031648,biological_process protein destabilization;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0033523,biological_process histone H2B ubiquitination;GO:0034402,biological_process recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:1902808,biological_process positive regulation of cell cycle G1/S phase transition;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	cell division cycle 73 [Source:HGNC Symbol%3BAcc:HGNC:16783]
ENSG00000123143	53.52	48.87	55.09	57.01	51.69	56.86	-0.0592860866266066	7.48802068638728	0.387123019990916	0.753684339244179	19:14433052-14471867:+	PKN1	50;GO:0000166,molecular_function nucleotide binding;GO:0001782,biological_process B cell homeostasis;GO:0001783,biological_process B cell apoptotic process;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002634,biological_process regulation of germinal center formation;GO:0002637,biological_process regulation of immunoglobulin production;GO:0003014,biological_process renal system process;GO:0003682,molecular_function chromatin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006972,biological_process hyperosmotic response;GO:0007165,biological_process signal transduction;GO:0007257,biological_process activation of JUN kinase activity;GO:0010631,biological_process epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0017049,molecular_function GTP-Rho binding;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030496,cellular_component midbody;GO:0030889,biological_process negative regulation of B cell proliferation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032154,cellular_component cleavage furrow;GO:0035402,molecular_function histone kinase activity (H3-T11 specific);GO:0035407,biological_process histone H3-T11 phosphorylation;GO:0042393,molecular_function histone binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043234,cellular_component protein complex;GO:0048365,molecular_function Rac GTPase binding;GO:0048536,biological_process spleen development;GO:0050681,molecular_function androgen receptor binding;GO:2000145,biological_process regulation of cell motility	PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]; K06071	protein kinase N1 [Source:HGNC Symbol%3BAcc:HGNC:9405]
ENSG00000140396	12.05	12.28	11.83	12.53	13.07	12.31	-0.0576123197709889	5.76728627661049	0.387133758722378	0.753684339244179	8:70109761-70403805:-	NCOA2	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001162,molecular_function RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0010906,biological_process regulation of glucose metabolic process;GO:0015721,biological_process bile acid and bile salt transport;GO:0016604,cellular_component nuclear body;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019904,molecular_function protein domain specific binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030375,molecular_function thyroid hormone receptor coactivator activity;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032870,biological_process cellular response to hormone stimulus;GO:0032922,biological_process circadian regulation of gene expression;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0043234,cellular_component protein complex;GO:0045475,biological_process locomotor rhythm;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:1904017,biological_process cellular response to Thyroglobulin triiodothyronine;GO:2000273,biological_process positive regulation of receptor activity	NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2; K11255	nuclear receptor coactivator 2 [Source:HGNC Symbol%3BAcc:HGNC:7669]
ENSG00000013619	1.77	2.23	1.67	1.70	1.85	1.58	0.140354872466177	2.65135962377005	0.387459202325838	0.754190772034473	X:150361421-150514178:+	MAMLD1	11;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008584,biological_process male gonad development;GO:0016604,cellular_component nuclear body	NA	mastermind like domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:2568]
ENSG00000162745	3.48	3.82	2.65	2.92	3.37	2.75	0.140935791454014	2.85465147343141	0.387605595336496	0.754190772034473	1:161983191-162023854:-	OLFML2B	5;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0030198,biological_process extracellular matrix organization;GO:0050840,molecular_function extracellular matrix binding	NA	olfactomedin like 2B [Source:HGNC Symbol%3BAcc:HGNC:24558]
ENSG00000177888	4.51	5.01	4.24	4.26	4.53	4.10	0.0984046428566986	3.61122558858255	0.387630687856954	0.754190772034473	1:197153679-197200542:-	ZBTB41	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 41 [Source:HGNC Symbol%3BAcc:HGNC:24819]
ENSG00000123472	35.01	32.30	32.76	34.24	32.97	38.65	-0.0684937520863516	5.30836416656558	0.387655808100932	0.754190772034473	1:46632736-46673867:-	ATPAF1	4;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006461,biological_process protein complex assembly;GO:0033615,biological_process mitochondrial proton-transporting ATP synthase complex assembly	NA	ATP synthase mitochondrial F1 complex assembly factor 1 [Source:HGNC Symbol%3BAcc:HGNC:18803]
ENSG00000204469	63.64	67.02	65.75	68.94	69.33	66.83	-0.0508523034821683	8.75967175330435	0.38781000563387	0.754190772034473	6:31620719-31637771:+	PRRC2A	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0070062,cellular_component extracellular exosome	NA	proline rich coiled-coil 2A [Source:HGNC Symbol%3BAcc:HGNC:13918]
ENSG00000113649	22.53	22.07	21.89	22.27	20.05	22.09	0.0575360577910683	6.17154794020833	0.38785595053268	0.754190772034473	5:146447310-146511961:+	TCERG1	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0070064,molecular_function proline-rich region binding	TCERG1, CA150; transcription elongation regulator 1; K12824	transcription elongation regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:15630]
ENSG00000196378	3.70	5.35	5.08	4.99	3.93	3.85	0.148182827759106	2.93170171163907	0.387866001941978	0.754190772034473	8:144773113-144787345:-	ZNF34	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 34 [Source:HGNC Symbol%3BAcc:HGNC:13098]
ENSG00000082781	247.75	255.70	244.20	245.00	245.12	237.96	0.0498467581920331	9.25335595588815	0.387879955584313	0.754190772034473	3:124761947-124901418:-	ITGB5	25;GO:0001618,molecular_function virus receptor activity;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006936,biological_process muscle contraction;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030198,biological_process extracellular matrix organization;GO:0034684,cellular_component integrin alphav-beta5 complex;GO:0035987,biological_process endodermal cell differentiation;GO:0043149,biological_process stress fiber assembly;GO:0043235,cellular_component receptor complex;GO:0045335,cellular_component phagocytic vesicle;GO:0046718,biological_process viral entry into host cell;GO:0070062,cellular_component extracellular exosome;GO:0090136,biological_process epithelial cell-cell adhesion	ITGB5; integrin beta 5; K06588	integrin subunit beta 5 [Source:HGNC Symbol%3BAcc:HGNC:6160]
ENSG00000120896	18.68	18.61	18.61	18.42	21.36	19.25	-0.0662665804752803	5.30114162530707	0.388129656270092	0.754558092917878	8:22544985-22575788:+	SORBS3	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006936,biological_process muscle contraction;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0008134,molecular_function transcription factor binding;GO:0017166,molecular_function vinculin binding;GO:0030054,cellular_component cell junction;GO:0031589,biological_process cell-substrate adhesion;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0051495,biological_process positive regulation of cytoskeleton organization;GO:0051496,biological_process positive regulation of stress fiber assembly	NA	sorbin and SH3 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:30907]
ENSG00000215021	150.66	155.61	148.48	158.92	154.95	161.30	-0.0522173270011116	7.55058363794424	0.388422587861667	0.755009330273546	12:6965326-6970825:-	PHB2	39;GO:0000060,biological_process protein import into nucleus, translocation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0007005,biological_process mitochondrion organization;GO:0007062,biological_process sister chromatid cohesion;GO:0008022,molecular_function protein C-terminus binding;GO:0009611,biological_process response to wounding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0030331,molecular_function estrogen receptor binding;GO:0030424,cellular_component axon;GO:0031536,biological_process positive regulation of exit from mitosis;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0033218,molecular_function amide binding;GO:0033600,biological_process negative regulation of mammary gland epithelial cell proliferation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0050821,biological_process protein stabilization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060744,biological_process mammary gland branching involved in thelarche;GO:0060749,biological_process mammary gland alveolus development;GO:0060762,biological_process regulation of branching involved in mammary gland duct morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071300,biological_process cellular response to retinoic acid;GO:0071456,biological_process cellular response to hypoxia;GO:0071944,cellular_component cell periphery;GO:1902808,biological_process positive regulation of cell cycle G1/S phase transition	NA	prohibitin 2 [Source:HGNC Symbol%3BAcc:HGNC:30306]
ENSG00000154114	10.92	9.50	10.87	8.67	10.37	10.49	0.101530887933638	3.7263488619959	0.388526466455292	0.755025787680604	11:121024071-121090775:+	TBCEL	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton	NA	tubulin folding cofactor E like [Source:HGNC Symbol%3BAcc:HGNC:28115]
ENSG00000162972	16.50	17.24	18.32	18.07	20.61	17.27	-0.0905352239589207	4.06386452159814	0.388552705365641	0.755025787680604	2:199955316-200008540:+	MAIP1	13;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0007007,biological_process inner mitochondrial membrane organization;GO:0032979,biological_process protein insertion into mitochondrial membrane from inner side;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0043022,molecular_function ribosome binding;GO:0051204,biological_process protein insertion into mitochondrial membrane;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0097033,biological_process mitochondrial respiratory chain complex III biogenesis;GO:0097034,biological_process mitochondrial respiratory chain complex IV biogenesis	NA	matrix AAA peptidase interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26198]
ENSG00000176714	1.60	2.02	1.22	1.86	1.83	1.96	-0.239314753307397	1.29776196782248	0.388638306603097	0.755073923910509	2:27625638-27629012:-	CCDC121	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 121 [Source:HGNC Symbol%3BAcc:HGNC:25833]
ENSG00000067225	1572.83	1730.41	1477.18	1648.42	1771.12	1611.38	-0.0619610726117729	11.5338519555993	0.388870748316303	0.755263824528111	15:72199028-72231822:-	PKM	50;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001666,biological_process response to hypoxia;GO:0001889,biological_process liver development;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004743,molecular_function pyruvate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0006006,biological_process glucose metabolic process;GO:0006096,biological_process glycolytic process;GO:0006754,biological_process ATP biosynthetic process;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0009629,biological_process response to gravity;GO:0010033,biological_process response to organic substance;GO:0012501,biological_process programmed cell death;GO:0014870,biological_process response to muscle inactivity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030955,molecular_function potassium ion binding;GO:0031012,cellular_component extracellular matrix;GO:0031100,biological_process organ regeneration;GO:0031982,cellular_component vesicle;GO:0032868,biological_process response to insulin;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034774,cellular_component secretory granule lumen;GO:0042802,molecular_function identical protein binding;GO:0042866,biological_process pyruvate biosynthetic process;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0043531,molecular_function ADP binding;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome;GO:0070324,molecular_function thyroid hormone binding;GO:1902912,cellular_component pyruvate kinase complex;GO:1903561,cellular_component extracellular vesicle;GO:1904813,cellular_component ficolin-1-rich granule lumen	PK, pyk; pyruvate kinase [EC:2.7.1.40]; K00873	pyruvate kinase%2C muscle [Source:HGNC Symbol%3BAcc:HGNC:9021]
ENSG00000254999	439.45	416.24	424.27	440.25	396.40	402.53	0.0593103949634468	6.56521327900512	0.388966733904649	0.755263824528111	3:10115591-10127190:+	BRK1	20;GO:0001701,biological_process in utero embryonic development;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0016601,biological_process Rac protein signal transduction;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0031209,cellular_component SCAR complex;GO:0032403,molecular_function protein complex binding;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0048870,biological_process cell motility;GO:0070062,cellular_component extracellular exosome;GO:0070207,biological_process protein homotrimerization;GO:2000601,biological_process positive regulation of Arp2/3 complex-mediated actin nucleation	C3ORF10, HSPC300; chromosome 3 open reading frame 10; K05752	BRICK1%2C SCAR/WAVE actin nucleating complex subunit [Source:HGNC Symbol%3BAcc:HGNC:23057]
ENSG00000273820	5.05	5.38	6.44	7.12	6.23	5.35	-0.132693613165206	2.99188288949422	0.388995745329308	0.755263824528111	X:49879947-49882565:+	USP27X	17;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0050821,biological_process protein stabilization;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	NA	ubiquitin specific peptidase 27%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:13486]
ENSG00000085415	45.29	44.96	46.75	46.38	46.13	51.30	-0.0584181405900405	5.97042512072339	0.38902606157838	0.755263824528111	18:12947132-12987536:+	SEH1L	41;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0002534,biological_process cytokine production involved in inflammatory response;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005694,cellular_component chromosome;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0006999,biological_process nuclear pore organization;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007080,biological_process mitotic metaphase plate congression;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031080,cellular_component nuclear pore outer ring;GO:0032008,biological_process positive regulation of TOR signaling;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034629,biological_process cellular protein complex localization;GO:0043657,cellular_component host cell;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051028,biological_process mRNA transport;GO:0051301,biological_process cell division;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0061700,cellular_component GATOR2 complex;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat;GO:1904263,biological_process positive regulation of TORC1 signaling	SEH1; nucleoporin SEH1; K14299	SEH1 like nucleoporin [Source:HGNC Symbol%3BAcc:HGNC:30379]
ENSG00000189079	7.70	7.67	7.33	7.64	8.43	7.81	-0.0627134628684718	5.43083081949189	0.389040271814448	0.755263824528111	12:45729664-45908040:+	ARID2	20;GO:0003007,biological_process heart morphogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006337,biological_process nucleosome disassembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0030336,biological_process negative regulation of cell migration;GO:0042592,biological_process homeostatic process;GO:0046872,molecular_function metal ion binding;GO:0048568,biological_process embryonic organ development;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060982,biological_process coronary artery morphogenesis;GO:0072358,biological_process cardiovascular system development;GO:0090544,cellular_component BAF-type complex	ARID2; AT-rich interactive domain-containing protein 2; K11765	AT-rich interaction domain 2 [Source:HGNC Symbol%3BAcc:HGNC:18037]
ENSG00000163125	15.08	15.08	14.84	15.61	16.31	15.24	-0.0555646456340354	6.08380398536534	0.389299502305165	0.755615614173681	1:150363090-150476566:+	RPRD2	3;GO:0005654,cellular_component nucleoplasm;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	regulation of nuclear pre-mRNA domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29039]
ENSG00000162300	33.68	33.86	34.38	31.85	31.66	34.85	0.062217381783138	5.23881298284428	0.389396449192364	0.755615614173681	11:65084222-65088400:+	ZFPL1	10;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:12868]
ENSG00000119203	30.63	31.62	28.34	32.07	31.97	30.98	-0.0592054206312915	5.99190654411186	0.389404099240235	0.755615614173681	2:9423567-9473101:+	CPSF3	21;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006379,biological_process mRNA cleavage;GO:0006397,biological_process mRNA processing;GO:0006398,biological_process mRNA 3'-end processing by stem-loop binding and cleavage;GO:0006406,biological_process mRNA export from nucleus;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031124,biological_process mRNA 3'-end processing;GO:0046872,molecular_function metal ion binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	CPSF3, YSH1; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]; K14403	cleavage and polyadenylation specific factor 3 [Source:HGNC Symbol%3BAcc:HGNC:2326]
ENSG00000163348	21.80	21.03	22.84	21.82	21.17	20.09	0.0733008500192216	4.71761040347689	0.389530860826646	0.755623239831342	1:154957025-154963853:-	PYGO2	24;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0002088,biological_process lens development in camera-type eye;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007286,biological_process spermatid development;GO:0007289,biological_process spermatid nucleus differentiation;GO:0007420,biological_process brain development;GO:0009791,biological_process post-embryonic development;GO:0016055,biological_process Wnt signaling pathway;GO:0030879,biological_process mammary gland development;GO:0033599,biological_process regulation of mammary gland epithelial cell proliferation;GO:0035034,molecular_function histone acetyltransferase regulator activity;GO:0035065,biological_process regulation of histone acetylation;GO:0035563,biological_process positive regulation of chromatin binding;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding;GO:0048589,biological_process developmental growth;GO:0051569,biological_process regulation of histone H3-K4 methylation;GO:0060021,biological_process palate development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:1904837,biological_process beta-catenin-TCF complex assembly	NA	pygopus family PHD finger 2 [Source:HGNC Symbol%3BAcc:HGNC:30257]
ENSG00000120500	3.55	3.74	3.32	3.82	2.39	3.17	0.181832154154687	2.01985436914966	0.38959633266646	0.755623239831342	X:70268304-70281840:+	ARR3	12;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0001932,biological_process regulation of protein phosphorylation;GO:0002046,molecular_function opsin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0007601,biological_process visual perception;GO:0045202,cellular_component synapse;GO:0050896,biological_process response to stimulus;GO:0051219,molecular_function phosphoprotein binding	NA	arrestin 3 [Source:HGNC Symbol%3BAcc:HGNC:710]
ENSG00000148218	13.89	13.44	15.20	13.10	14.17	13.00	0.0951302166829615	3.82778462705203	0.389630210508479	0.755623239831342	9:113386316-113401333:-	ALAD	58;GO:0001666,biological_process response to hypoxia;GO:0003824,molecular_function catalytic activity;GO:0004655,molecular_function porphobilinogen synthase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0006979,biological_process response to oxidative stress;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009635,biological_process response to herbicide;GO:0009636,biological_process response to toxic substance;GO:0009725,biological_process response to hormone;GO:0010033,biological_process response to organic substance;GO:0010035,biological_process response to inorganic substance;GO:0010038,biological_process response to metal ion;GO:0010039,biological_process response to iron ion;GO:0010043,biological_process response to zinc ion;GO:0010044,biological_process response to aluminum ion;GO:0010212,biological_process response to ionizing radiation;GO:0010266,biological_process response to vitamin B1;GO:0010269,biological_process response to selenium ion;GO:0010288,biological_process response to lead ion;GO:0014070,biological_process response to organic cyclic compound;GO:0014823,biological_process response to activity;GO:0016829,molecular_function lyase activity;GO:0031667,biological_process response to nutrient levels;GO:0032025,biological_process response to cobalt ion;GO:0032496,biological_process response to lipopolysaccharide;GO:0033014,biological_process tetrapyrrole biosynthetic process;GO:0033197,biological_process response to vitamin E;GO:0033273,biological_process response to vitamin;GO:0034774,cellular_component secretory granule lumen;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0043200,biological_process response to amino acid;GO:0043312,biological_process neutrophil degranulation;GO:0045471,biological_process response to ethanol;GO:0046685,biological_process response to arsenic-containing substance;GO:0046686,biological_process response to cadmium ion;GO:0046689,biological_process response to mercury ion;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization;GO:0051384,biological_process response to glucocorticoid;GO:0051597,biological_process response to methylmercury;GO:0070062,cellular_component extracellular exosome;GO:0070541,biological_process response to platinum ion;GO:0070542,biological_process response to fatty acid;GO:0071284,biological_process cellular response to lead ion;GO:0071353,biological_process cellular response to interleukin-4;GO:1901799,biological_process negative regulation of proteasomal protein catabolic process;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1904854,molecular_function proteasome core complex binding	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]; K01698	aminolevulinate dehydratase [Source:HGNC Symbol%3BAcc:HGNC:395]
ENSG00000122591	22.29	18.70	23.05	23.41	20.04	24.98	-0.0800459455956329	5.50525720348285	0.389651523254686	0.755623239831342	7:22889370-23014130:-	FAM126A	11;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0042552,biological_process myelination;GO:0043005,cellular_component neuron projection;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	family with sequence similarity 126 member A [Source:HGNC Symbol%3BAcc:HGNC:24587]
ENSG00000172469	19.08	20.83	19.89	19.55	18.91	18.95	0.0665810258667743	4.81660079462065	0.389800883111628	0.755794808195039	6:95577542-95609457:+	MANEA	8;GO:0000139,cellular_component Golgi membrane;GO:0004559,molecular_function alpha-mannosidase activity;GO:0004569,molecular_function glycoprotein endo-alpha-1,2-mannosidase activity;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds	NA	mannosidase endo-alpha [Source:HGNC Symbol%3BAcc:HGNC:21072]
ENSG00000170291	29.70	31.40	28.87	33.60	29.14	32.30	-0.0710168710993917	5.13196983968632	0.390127048334451	0.756218915565962	17:7251415-7259940:+	ELP5	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030335,biological_process positive regulation of cell migration;GO:0033588,cellular_component Elongator holoenzyme complex	NA	elongator acetyltransferase complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:30617]
ENSG00000130703	26.64	25.17	28.64	29.14	26.90	28.90	-0.0633842653178544	5.38834406844066	0.390141459380039	0.756218915565962	20:62231921-62296213:+	OSBPL2	9;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006699,biological_process bile acid biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0015248,molecular_function sterol transporter activity;GO:0015485,molecular_function cholesterol binding;GO:0015918,biological_process sterol transport	NA	oxysterol binding protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:15761]
ENSG00000129562	412.05	437.44	424.32	416.55	417.55	403.26	0.052904917086248	7.24526201188121	0.390428403718868	0.756572996388454	14:22564904-22589269:-	DAD1	17;GO:0001824,biological_process blastocyst development;GO:0004576,molecular_function oligosaccharyl transferase activity;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006915,biological_process apoptotic process;GO:0007584,biological_process response to nutrient;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0070062,cellular_component extracellular exosome	OST2, DAD1; oligosaccharyltransferase complex subunit epsilon; K12668	defender against cell death 1 [Source:HGNC Symbol%3BAcc:HGNC:2664]
ENSG00000165526	14.92	14.45	13.02	16.29	13.68	15.48	-0.0905797338840844	4.06408370287109	0.390504265877592	0.756572996388454	11:126202093-126211692:-	RPUSD4	8;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0019239,molecular_function deaminase activity;GO:0031119,biological_process tRNA pseudouridine synthesis	NA	RNA pseudouridylate synthase domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25898]
ENSG00000136051	18.58	19.07	18.40	18.53	19.65	20.59	-0.0580186097828765	6.08112481955652	0.390506983634965	0.756572996388454	12:105107323-105169134:+	WASHC4	8;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0007032,biological_process endosome organization;GO:0015031,biological_process protein transport;GO:0016197,biological_process endosomal transport;GO:0031083,cellular_component BLOC-1 complex;GO:0071203,cellular_component WASH complex	NA	WASH complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:29174]
ENSG00000145979	21.47	20.99	21.30	22.06	22.60	22.77	-0.0680527724754144	4.67643619304765	0.390798002437039	0.75686804288537	6:13266541-13328583:-	TBC1D7	13;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0017137,molecular_function Rab GTPase binding;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032007,biological_process negative regulation of TOR signaling;GO:0036064,cellular_component ciliary basal body;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization;GO:0070848,biological_process response to growth factor;GO:0090630,biological_process activation of GTPase activity;GO:1902018,biological_process negative regulation of cilium assembly	NA	TBC1 domain family member 7 [Source:HGNC Symbol%3BAcc:HGNC:21066]
ENSG00000141428	13.27	14.19	16.95	16.00	16.43	15.98	-0.110399146259295	3.37611352243465	0.390810291412092	0.75686804288537	18:35972082-35979286:+	C18orf21	NA	NA	chromosome 18 open reading frame 21 [Source:HGNC Symbol%3BAcc:HGNC:28802]
ENSG00000161395	10.53	10.84	11.02	9.33	11.84	9.46	0.0935593415157647	4.17769436634542	0.390842194062291	0.75686804288537	17:39671121-39696797:-	PGAP3	10;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006505,biological_process GPI anchor metabolic process;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0031227,cellular_component intrinsic component of endoplasmic reticulum membrane	NA	post-GPI attachment to proteins 3 [Source:HGNC Symbol%3BAcc:HGNC:23719]
ENSG00000135723	17.82	17.88	17.72	17.98	17.12	16.73	0.0553954691525148	5.98549961474732	0.390966625436885	0.75699090961598	16:67229386-67247658:-	FHOD1	19;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007097,biological_process nuclear migration;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0032059,cellular_component bleb;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043621,molecular_function protein self-association;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051660,biological_process establishment of centrosome localization	NA	formin homology 2 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17905]
ENSG00000109819	1.84	3.76	2.21	2.22	2.77	1.72	0.215686843792682	2.5990527629902	0.391077653716362	0.757087790951529	4:23755040-23904089:-	PPARGC1A	127;GO:0000302,biological_process response to reactive oxygen species;GO:0000422,biological_process mitophagy;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001659,biological_process temperature homeostasis;GO:0001666,biological_process response to hypoxia;GO:0001678,biological_process cellular glucose homeostasis;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002021,biological_process response to dietary excess;GO:0002931,biological_process response to ischemia;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005719,cellular_component nuclear euchromatin;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006012,biological_process galactose metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0006461,biological_process protein complex assembly;GO:0007005,biological_process mitochondrion organization;GO:0007568,biological_process aging;GO:0007586,biological_process digestion;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0008209,biological_process androgen metabolic process;GO:0008380,biological_process RNA splicing;GO:0009409,biological_process response to cold;GO:0009750,biological_process response to fructose;GO:0010822,biological_process positive regulation of mitochondrion organization;GO:0014070,biological_process response to organic cyclic compound;GO:0014732,biological_process skeletal muscle atrophy;GO:0014823,biological_process response to activity;GO:0014850,biological_process response to muscle activity;GO:0014878,biological_process response to electrical stimulus involved in regulation of muscle adaptation;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016605,cellular_component PML body;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019395,biological_process fatty acid oxidation;GO:0021549,biological_process cerebellum development;GO:0022626,cellular_component cytosolic ribosome;GO:0022904,biological_process respiratory electron transport chain;GO:0030331,molecular_function estrogen receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030900,biological_process forebrain development;GO:0031325,biological_process positive regulation of cellular metabolic process;GO:0031490,molecular_function chromatin DNA binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031667,biological_process response to nutrient levels;GO:0032922,biological_process circadian regulation of gene expression;GO:0034599,biological_process cellular response to oxidative stress;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035865,biological_process cellular response to potassium ion;GO:0042493,biological_process response to drug;GO:0042594,biological_process response to starvation;GO:0042752,biological_process regulation of circadian rhythm;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0043014,molecular_function alpha-tubulin binding;GO:0043025,cellular_component neuronal cell body;GO:0043201,biological_process response to leucine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045333,biological_process cellular respiration;GO:0045722,biological_process positive regulation of gluconeogenesis;GO:0045820,biological_process negative regulation of glycolytic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046321,biological_process positive regulation of fatty acid oxidation;GO:0048511,biological_process rhythmic process;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050681,molecular_function androgen receptor binding;GO:0050821,biological_process protein stabilization;GO:0050873,biological_process brown fat cell differentiation;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051552,biological_process flavone metabolic process;GO:0051602,biological_process response to electrical stimulus;GO:0060612,biological_process adipose tissue development;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071250,biological_process cellular response to nitrite;GO:0071313,biological_process cellular response to caffeine;GO:0071332,biological_process cellular response to fructose stimulus;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071354,biological_process cellular response to interleukin-6;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071398,biological_process cellular response to fatty acid;GO:0071456,biological_process cellular response to hypoxia;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071871,biological_process response to epinephrine;GO:0071873,biological_process response to norepinephrine;GO:0090258,biological_process negative regulation of mitochondrial fission;GO:0097066,biological_process response to thyroid hormone;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:0097440,cellular_component apical dendrite;GO:1901215,biological_process negative regulation of neuron death;GO:1901558,biological_process response to metformin;GO:1901857,biological_process positive regulation of cellular respiration;GO:1901860,biological_process positive regulation of mitochondrial DNA metabolic process;GO:1901863,biological_process positive regulation of muscle tissue development;GO:1903506,biological_process regulation of nucleic acid-templated transcription;GO:1904635,biological_process positive regulation of glomerular visceral epithelial cell apoptotic process;GO:1904637,biological_process cellular response to ionomycin;GO:1904639,biological_process cellular response to resveratrol;GO:1904640,biological_process response to methionine;GO:1990841,molecular_function promoter-specific chromatin binding;GO:1990843,cellular_component subsarcolemmal mitochondrion;GO:1990844,cellular_component interfibrillar mitochondrion;GO:1990845,biological_process adaptive thermogenesis;GO:2000184,biological_process positive regulation of progesterone biosynthetic process;GO:2000272,biological_process negative regulation of receptor activity;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000507,biological_process positive regulation of energy homeostasis;GO:2001171,biological_process positive regulation of ATP biosynthetic process	PPARGC1A, PGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha; K07202	PPARG coactivator 1 alpha [Source:HGNC Symbol%3BAcc:HGNC:9237]
ENSG00000136158	5.90	8.19	6.85	6.02	6.42	6.62	0.129989785885373	2.67992170043535	0.391297368012223	0.757196219482079	13:80335975-80340951:-	SPRY2	46;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007605,biological_process sensory perception of sound;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009966,biological_process regulation of signal transduction;GO:0010628,biological_process positive regulation of gene expression;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0030324,biological_process lung development;GO:0030335,biological_process positive regulation of cell migration;GO:0031345,biological_process negative regulation of cell projection organization;GO:0032587,cellular_component ruffle membrane;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034260,biological_process negative regulation of GTPase activity;GO:0040037,biological_process negative regulation of fibroblast growth factor receptor signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042472,biological_process inner ear morphogenesis;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0045165,biological_process cell fate commitment;GO:0045595,biological_process regulation of cell differentiation;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0051387,biological_process negative regulation of neurotrophin TRK receptor signaling pathway;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060425,biological_process lung morphogenesis;GO:0060437,biological_process lung growth;GO:0060449,biological_process bud elongation involved in lung branching;GO:0060541,biological_process respiratory system development;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	SPRY2; protein sprouty homolog 2; K17383	sprouty RTK signaling antagonist 2 [Source:HGNC Symbol%3BAcc:HGNC:11270]
ENSG00000166897	18.20	15.81	18.76	16.19	18.28	16.24	0.0745921343057399	5.4148050623549	0.391343599242034	0.757196219482079	22:37367959-37427470:-	ELFN2	6;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005615,cellular_component extracellular space;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019902,molecular_function phosphatase binding	NA	extracellular leucine rich repeat and fibronectin type III domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29396]
ENSG00000119703	2.05	1.08	2.08	2.22	1.82	2.14	-0.201345246268446	1.52787298496918	0.391382344006075	0.757196219482079	14:75064169-75079987:+	ZC2HC1C	2;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger C2HC-type containing 1C [Source:HGNC Symbol%3BAcc:HGNC:20354]
ENSG00000179912	20.74	16.72	20.28	17.99	19.33	18.22	0.0726246342336112	5.90100045186686	0.391435717152761	0.757196219482079	12:57253761-57431005:-	R3HDM2	3;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus	NA	R3H domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29167]
ENSG00000145850	14.57	13.23	16.88	14.00	13.58	14.76	0.0961692256388893	4.05724734253812	0.391491077679067	0.757196219482079	5:156919281-156963255:-	TIMD4	3;GO:0001786,molecular_function phosphatidylserine binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	T-cell immunoglobulin and mucin domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25132]
ENSG00000127124	0.45	0.70	0.59	0.53	0.48	0.53	0.16982375714756	2.02136758140272	0.39149966459647	0.757196219482079	1:41506364-42035925:-	HIVEP3	15;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	human immunodeficiency virus type I enhancer binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:13561]
ENSG00000184983	77.66	71.98	75.67	81.68	81.75	74.58	-0.0633951344996388	5.16509727321147	0.391684454492327	0.75743560268161	22:42085524-42090955:-	NDUFA6	11;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006979,biological_process response to oxidative stress;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6; K03950	NADH:ubiquinone oxidoreductase subunit A6 [Source:HGNC Symbol%3BAcc:HGNC:7690]
ENSG00000204410	0.67	0.36	0.36	0.31	0.43	0.40	0.322331340942309	0.354857463016382	0.391760108797906	0.757463898833086	6:31739947-31762834:+	MSH5	12;GO:0000166,molecular_function nucleotide binding;GO:0000795,cellular_component synaptonemal complex;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0030983,molecular_function mismatched DNA binding;GO:0051026,biological_process chiasma assembly;GO:0051321,biological_process meiotic cell cycle	NA	mutS homolog 5 [Source:HGNC Symbol%3BAcc:HGNC:7328]
ENSG00000078399	33.24	34.31	35.90	32.39	30.86	35.85	0.0721289667561072	4.79257770384274	0.392010832830491	0.757830628862308	7:27162434-27175180:-	HOXA9	10;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0019899,molecular_function enzyme binding;GO:0042118,biological_process endothelial cell activation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045638,biological_process negative regulation of myeloid cell differentiation	NA	homeobox A9 [Source:HGNC Symbol%3BAcc:HGNC:5109]
ENSG00000131269	27.14	25.48	26.27	26.69	24.22	25.55	0.0584123842698717	5.89801945705859	0.39210503669152	0.757894708883812	X:75053171-75156732:-	ABCB7	13;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0015232,molecular_function heme transporter activity;GO:0015886,biological_process heme transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0055085,biological_process transmembrane transport	ABCB7; ATP-binding cassette, subfamily B (MDR/TAP), member 7; K05662	ATP binding cassette subfamily B member 7 [Source:HGNC Symbol%3BAcc:HGNC:48]
ENSG00000115514	38.61	51.88	42.63	48.03	46.69	47.12	-0.0877833909355397	5.1439779056024	0.392236750911072	0.758031260946463	2:99318981-99340702:-	TXNDC9	13;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0008150,biological_process biological_process;GO:0008479,molecular_function queuine tRNA-ribosyltransferase activity;GO:0008616,biological_process queuosine biosynthetic process;GO:0030496,cellular_component midbody;GO:0045296,molecular_function cadherin binding;GO:0045454,biological_process cell redox homeostasis	NA	thioredoxin domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:24110]
ENSG00000166747	24.38	24.42	23.00	24.64	26.94	23.90	-0.0604923516540272	5.99905594458698	0.39233012004416	0.758067410269791	16:71728999-71809201:-	AP1G1	34;GO:0000139,cellular_component Golgi membrane;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017137,molecular_function Rab GTPase binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019894,molecular_function kinesin binding;GO:0030117,cellular_component membrane coat;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032438,biological_process melanosome organization;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035646,biological_process endosome to melanosome transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043323,biological_process positive regulation of natural killer cell degranulation;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0055037,cellular_component recycling endosome;GO:0090160,biological_process Golgi to lysosome transport	AP1G1; AP-1 complex subunit gamma-1; K12391	adaptor related protein complex 1 gamma 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:555]
ENSG00000167565	24.86	27.63	28.66	29.03	29.02	28.70	-0.0873719792581286	4.05409960494913	0.392391611880352	0.758067410269791	19:40440843-40444705:-	SERTAD3	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030308,biological_process negative regulation of cell growth;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	SERTA domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:17931]
ENSG00000196511	5.82	5.65	8.85	7.48	9.34	6.34	-0.167339769487307	2.93704216927989	0.392438667396574	0.758067410269791	7:144451940-144836395:-	TPK1	11;GO:0000166,molecular_function nucleotide binding;GO:0004788,molecular_function thiamine diphosphokinase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006772,biological_process thiamine metabolic process;GO:0009229,biological_process thiamine diphosphate biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030975,molecular_function thiamine binding;GO:0042723,biological_process thiamine-containing compound metabolic process	thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]; K00949	thiamin pyrophosphokinase 1 [Source:HGNC Symbol%3BAcc:HGNC:17358]
ENSG00000135519	0.91	0.85	1.06	0.81	0.86	0.84	0.191031385444667	1.60995139146601	0.392548605350261	0.758143422735176	12:49539156-49558308:+	KCNH3	20;GO:0000155,molecular_function phosphorelay sensor kinase activity;GO:0000160,biological_process phosphorelay signal transduction system;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport	NA	potassium voltage-gated channel subfamily H member 3 [Source:HGNC Symbol%3BAcc:HGNC:6252]
ENSG00000054148	342.95	329.59	339.76	328.39	317.66	338.18	0.0527836460057321	7.1633937754062	0.39266664143063	0.758143422735176	9:136848723-136851027:+	PHPT1	16;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0008969,molecular_function phosphohistidine phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0035971,biological_process peptidyl-histidine dephosphorylation;GO:0044325,molecular_function ion channel binding;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0051350,biological_process negative regulation of lyase activity;GO:0070062,cellular_component extracellular exosome;GO:2000147,biological_process positive regulation of cell motility;GO:2000249,biological_process regulation of actin cytoskeleton reorganization;GO:2000984,biological_process negative regulation of ATP citrate synthase activity	NA	phosphohistidine phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:30033]
ENSG00000103051	36.85	39.19	39.66	40.34	40.49	40.37	-0.055977650290925	6.57469213298014	0.392683384166741	0.758143422735176	16:70480567-70523565:-	COG4	13;GO:0000139,cellular_component Golgi membrane;GO:0000301,biological_process retrograde transport, vesicle recycling within Golgi;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032588,cellular_component trans-Golgi network membrane;GO:0048213,biological_process Golgi vesicle prefusion complex stabilization	NA	component of oligomeric golgi complex 4 [Source:HGNC Symbol%3BAcc:HGNC:18620]
ENSG00000136628	86.96	84.45	84.63	85.27	90.52	91.54	-0.0503024399289134	8.63628477835351	0.392746878064172	0.758143422735176	1:219968600-220046658:-	EPRS	30;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004818,molecular_function glutamate-tRNA ligase activity;GO:0004827,molecular_function proline-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006424,biological_process glutamyl-tRNA aminoacylation;GO:0006433,biological_process prolyl-tRNA aminoacylation;GO:0006461,biological_process protein complex assembly;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0017148,biological_process negative regulation of translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035613,molecular_function RNA stem-loop binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043039,biological_process tRNA aminoacylation;GO:0051020,molecular_function GTPase binding;GO:0071346,biological_process cellular response to interferon-gamma;GO:0097452,cellular_component GAIT complex	EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]; K14163	glutamyl-prolyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:3418]
ENSG00000156639	65.63	59.40	65.47	68.65	65.87	65.87	-0.0573153640968529	5.72117450315266	0.392783400596948	0.758143422735176	6:37819498-38154624:+	ZFAND3	3;GO:0003677,molecular_function DNA binding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger AN1-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:18019]
ENSG00000133812	19.37	17.98	19.57	18.12	17.37	19.62	0.0594468752261113	6.72336478146381	0.393173298671202	0.758778009391422	11:9778666-10294207:-	SBF2	16;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005774,cellular_component vacuolar membrane;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0019208,molecular_function phosphatase regulator activity;GO:0019902,molecular_function phosphatase binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042552,biological_process myelination;GO:0042803,molecular_function protein homodimerization activity;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051262,biological_process protein tetramerization;GO:0061024,biological_process membrane organization	NA	SET binding factor 2 [Source:HGNC Symbol%3BAcc:HGNC:2135]
ENSG00000256229	4.14	2.77	2.66	3.10	4.24	3.61	-0.171015251488013	2.42999869155637	0.393291014293912	0.758887200439971	19:20167227-20200490:+	ZNF486	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 486 [Source:HGNC Symbol%3BAcc:HGNC:20807]
ENSG00000170917	56.94	59.10	59.99	62.64	59.74	61.92	-0.0553493421178856	5.94414424060568	0.393463411418968	0.759101853581543	4:122888696-122922968:-	NUDT6	7;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0008083,molecular_function growth factor activity;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity	NA	nudix hydrolase 6 [Source:HGNC Symbol%3BAcc:HGNC:8053]
ENSG00000163625	12.41	12.85	12.68	12.73	14.08	12.94	-0.0561248495487907	7.1074725728901	0.393624521964533	0.759220171342002	4:84669609-84966391:-	WDFY3	20;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0016605,cellular_component PML body;GO:0019898,cellular_component extrinsic component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0034274,cellular_component Atg12-Atg5-Atg16 complex;GO:0035973,biological_process aggrephagy;GO:0046872,molecular_function metal ion binding;GO:0097635,cellular_component extrinsic component of autophagosome membrane	NA	WD repeat and FYVE domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:20751]
ENSG00000249915	136.07	138.29	135.52	142.72	143.79	142.08	-0.0531792209022703	6.35914971839296	0.393655072418026	0.759220171342002	5:271620-353856:+	PDCD6	45;GO:0000139,cellular_component Golgi membrane;GO:0000287,molecular_function magnesium ion binding;GO:0001525,biological_process angiogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006508,biological_process proteolysis;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0014029,biological_process neural crest formation;GO:0014032,biological_process neural crest cell development;GO:0016020,cellular_component membrane;GO:0030127,cellular_component COPII vesicle coat;GO:0030948,biological_process negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032007,biological_process negative regulation of TOR signaling;GO:0034605,biological_process cellular response to heat;GO:0036324,biological_process vascular endothelial growth factor receptor-2 signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043495,molecular_function protein anchor;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0048208,biological_process COPII vesicle coating;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051592,biological_process response to calcium ion;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060090,molecular_function binding, bridging;GO:0070062,cellular_component extracellular exosome;GO:0070971,cellular_component endoplasmic reticulum exit site;GO:0097190,biological_process apoptotic signaling pathway;GO:1902527,biological_process positive regulation of protein monoubiquitination	NA	programmed cell death 6 [Source:HGNC Symbol%3BAcc:HGNC:8765]
ENSG00000244754	20.45	18.90	20.45	19.29	17.78	20.73	0.0622139816312655	6.14383612417049	0.393709450519452	0.759220171342002	13:32432416-32538885:-	N4BP2L2	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0017053,cellular_component transcriptional repressor complex;GO:0019899,molecular_function enzyme binding;GO:0070062,cellular_component extracellular exosome;GO:1902035,biological_process positive regulation of hematopoietic stem cell proliferation;GO:1902037,biological_process negative regulation of hematopoietic stem cell differentiation	NA	NEDD4 binding protein 2 like 2 [Source:HGNC Symbol%3BAcc:HGNC:26916]
ENSG00000170515	55.07	58.61	48.41	54.05	51.50	50.37	0.0649587531957534	6.06607212025676	0.393773195709386	0.759220171342002	12:56104318-56113907:+	PA2G4	23;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006417,biological_process regulation of translation;GO:0007050,biological_process cell cycle arrest;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035578,cellular_component azurophil granule lumen;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070062,cellular_component extracellular exosome	NA	proliferation-associated 2G4 [Source:HGNC Symbol%3BAcc:HGNC:8550]
ENSG00000109016	11.48	12.84	13.00	10.77	12.97	11.30	0.100523788088147	3.69624809004101	0.39404530643477	0.759220171342002	17:21123363-21193265:+	DHRS7B	8;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	dehydrogenase/reductase 7B [Source:HGNC Symbol%3BAcc:HGNC:24547]
ENSG00000137962	126.86	134.03	130.50	120.84	131.73	128.00	0.0521121930163965	8.96224446066843	0.394048079828086	0.759220171342002	1:94148987-94275068:-	ARHGAP29	11;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0030165,molecular_function PDZ domain binding;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 29 [Source:HGNC Symbol%3BAcc:HGNC:30207]
ENSG00000082497	3.11	2.06	1.52	2.59	2.70	2.63	-0.222090031753244	1.470977672919	0.394095804965559	0.759220171342002	1:210232798-210246631:+	SERTAD4	1;GO:0005634,cellular_component nucleus	NA	SERTA domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25236]
ENSG00000014138	12.69	13.04	10.89	11.39	12.32	11.13	0.0799451631148533	4.52252792829217	0.394162201929048	0.759220171342002	11:65261761-65305589:+	POLA2	14;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005658,cellular_component alpha DNA polymerase:primase complex;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0046982,molecular_function protein heterodimerization activity;GO:0071897,biological_process DNA biosynthetic process	POLA2; DNA polymerase alpha subunit B; K02321	DNA polymerase alpha 2%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:30073]
ENSG00000072518	14.93	12.92	12.32	12.79	13.45	12.28	0.07567052428242	5.11824103178147	0.39418250210697	0.759220171342002	11:63838927-63911019:+	MARK2	41;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000287,molecular_function magnesium ion binding;GO:0000422,biological_process mitophagy;GO:0001764,biological_process neuron migration;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0008289,molecular_function lipid binding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016328,cellular_component lateral plasma membrane;GO:0016740,molecular_function transferase activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030010,biological_process establishment of cell polarity;GO:0030154,biological_process cell differentiation;GO:0030295,molecular_function protein kinase activator activity;GO:0032147,biological_process activation of protein kinase activity;GO:0035556,biological_process intracellular signal transduction;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045296,molecular_function cadherin binding;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050321,molecular_function tau-protein kinase activity;GO:0050770,biological_process regulation of axonogenesis;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0051646,biological_process mitochondrion localization;GO:0097427,cellular_component microtubule bundle	NA	microtubule affinity regulating kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:3332]
ENSG00000168439	140.01	151.37	136.89	139.97	138.99	136.95	0.053196019641741	8.04095877674895	0.394243527809811	0.759220171342002	11:64185271-64204543:+	STIP1	12;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006950,biological_process response to stress;GO:0008022,molecular_function protein C-terminus binding;GO:0030544,molecular_function Hsp70 protein binding;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0051087,molecular_function chaperone binding	STIP1; stress-induced-phosphoprotein 1; K09553	stress induced phosphoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:11387]
ENSG00000136161	5.37	5.87	4.09	5.39	5.54	5.88	-0.132789845396065	3.21592103946552	0.394356675273576	0.759220171342002	13:48488958-48533256:-	RCBTB2	4;GO:0001669,cellular_component acrosomal vesicle;GO:0005087,molecular_function Ran guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0043547,biological_process positive regulation of GTPase activity	NA	RCC1 and BTB domain containing protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1914]
ENSG00000025800	23.15	23.53	22.75	23.37	26.37	23.48	-0.0653977283468418	5.26294094097217	0.394399613079844	0.759220171342002	1:32108037-32176568:+	KPNA6	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060135,biological_process maternal process involved in female pregnancy	NA	karyopherin subunit alpha 6 [Source:HGNC Symbol%3BAcc:HGNC:6399]
ENSG00000174791	12.04	9.32	9.99	11.94	10.26	11.48	-0.0855523154002651	4.68982486082018	0.394440098260417	0.759220171342002	11:66330241-66336840:-	RIN1	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	Ras and Rab interactor 1 [Source:HGNC Symbol%3BAcc:HGNC:18749]
ENSG00000006327	99.36	103.09	98.72	107.84	103.36	103.97	-0.0548950687740527	6.43084869540052	0.394465245625582	0.759220171342002	16:3018444-3022383:+	TNFRSF12A	19;GO:0001525,biological_process angiogenesis;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006931,biological_process substrate-dependent cell migration, cell attachment to substrate;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045765,biological_process regulation of angiogenesis;GO:0045773,biological_process positive regulation of axon extension;GO:0061041,biological_process regulation of wound healing;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	TNFRSF12A, FN14, TWEAKR, CD266; tumor necrosis factor receptor superfamily member 12A; K05149	TNF receptor superfamily member 12A [Source:HGNC Symbol%3BAcc:HGNC:18152]
ENSG00000119922	15.89	13.19	16.36	17.31	14.55	16.94	-0.0842123814484611	4.52409347353052	0.394488875393871	0.759220171342002	10:89283693-89309276:+	IFIT2	15;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009615,biological_process response to virus;GO:0032091,biological_process negative regulation of protein binding;GO:0035457,biological_process cellular response to interferon-alpha;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045087,biological_process innate immune response;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway	NA	interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol%3BAcc:HGNC:5409]
ENSG00000157593	64.96	71.08	71.22	65.80	71.34	63.05	0.0610964520619245	6.46213960901683	0.394517361854153	0.759220171342002	6:44254095-44257890:-	SLC35B2	15;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046963,biological_process 3'-phosphoadenosine 5'-phosphosulfate transport;GO:0046964,molecular_function 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity;GO:0050428,biological_process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0055085,biological_process transmembrane transport;GO:1902559,biological_process 3'-phospho-5'-adenylyl sulfate transmembrane transport	NA	solute carrier family 35 member B2 [Source:HGNC Symbol%3BAcc:HGNC:16872]
ENSG00000108559	20.25	19.21	18.73	21.43	18.85	21.02	-0.0633156400706366	5.55974201742528	0.394624176083193	0.759220171342002	17:5360962-5420160:-	NUP88	23;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0000056,biological_process ribosomal small subunit export from nucleus;GO:0000278,biological_process mitotic cell cycle;GO:0005215,molecular_function transporter activity;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP88; nuclear pore complex protein Nup88; K14318	nucleoporin 88 [Source:HGNC Symbol%3BAcc:HGNC:8067]
ENSG00000141499	7.25	6.67	5.27	6.52	8.37	6.29	-0.130877259724189	3.51466462347295	0.394696350030952	0.759220171342002	17:7686070-7703502:+	WRAP53	20;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007004,biological_process telomere maintenance via telomerase;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0032203,biological_process telomere formation via telomerase;GO:0032403,molecular_function protein complex binding;GO:0051087,molecular_function chaperone binding;GO:0051973,biological_process positive regulation of telomerase activity;GO:0070034,molecular_function telomerase RNA binding;GO:0070200,biological_process establishment of protein localization to telomere;GO:0090666,biological_process scaRNA localization to Cajal body;GO:0090671,biological_process telomerase RNA localization to Cajal body;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904867,biological_process protein localization to Cajal body	NA	WD repeat containing antisense to TP53 [Source:HGNC Symbol%3BAcc:HGNC:25522]
ENSG00000159496	4.21	4.14	5.04	4.50	3.88	4.09	0.119372301792992	3.15644235185107	0.394715306974098	0.759220171342002	22:23688135-23699176:+	RGL4	5;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity	NA	ral guanine nucleotide dissociation stimulator like 4 [Source:HGNC Symbol%3BAcc:HGNC:31911]
ENSG00000110400	5.36	5.81	6.45	6.33	7.30	5.59	-0.111544819168683	3.61819108095068	0.394774094887896	0.759220171342002	11:119623407-119729084:-	NECTIN1	46;GO:0001618,molecular_function virus receptor activity;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0002934,biological_process desmosome organization;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0006826,biological_process iron ion transport;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0008037,biological_process cell recognition;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016342,cellular_component catenin complex;GO:0030054,cellular_component cell junction;GO:0030246,molecular_function carbohydrate binding;GO:0030424,cellular_component axon;GO:0032584,cellular_component growth cone membrane;GO:0034332,biological_process adherens junction organization;GO:0042734,cellular_component presynaptic membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043296,cellular_component apical junction complex;GO:0044291,cellular_component cell-cell contact zone;GO:0045202,cellular_component synapse;GO:0046718,biological_process viral entry into host cell;GO:0046790,molecular_function virion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051963,biological_process regulation of synapse assembly;GO:0060041,biological_process retina development in camera-type eye;GO:0070166,biological_process enamel mineralization;GO:1902414,biological_process protein localization to cell junction	PVRL1, CD111; poliovirus receptor-related protein 1; K06081	nectin cell adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:9706]
ENSG00000087903	3.22	3.52	3.32	3.62	3.88	3.50	-0.120363592764783	2.95752288358542	0.395060185650319	0.759220171342002	19:5993163-6199572:-	RFX2	18;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001675,biological_process acrosome assembly;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0030030,biological_process cell projection organization;GO:0030154,biological_process cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060271,biological_process cilium morphogenesis;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	regulatory factor X2 [Source:HGNC Symbol%3BAcc:HGNC:9983]
ENSG00000163629	52.70	48.53	51.47	50.92	53.57	55.20	-0.0523606355609981	8.63078330132183	0.395081738071861	0.759220171342002	4:86594314-86815171:+	PTPN13	20;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030027,cellular_component lamellipodium;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0036312,molecular_function phosphatidylinositol 3-kinase regulatory subunit binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0044297,cellular_component cell body;GO:0070062,cellular_component extracellular exosome	PTPN13, FAP-1; tyrosine-protein phosphatase non-receptor type 13; K02374	protein tyrosine phosphatase%2C non-receptor type 13 [Source:HGNC Symbol%3BAcc:HGNC:9646]
ENSG00000015532	18.99	17.90	17.91	17.67	18.09	17.37	0.0583150412170238	5.62505531477781	0.395107342905376	0.759220171342002	17:50346091-50363138:+	XYLT2	18;GO:0000139,cellular_component Golgi membrane;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030158,molecular_function protein xylosyltransferase activity;GO:0030166,biological_process proteoglycan biosynthetic process;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030210,biological_process heparin biosynthetic process;GO:0050650,biological_process chondroitin sulfate proteoglycan biosynthetic process	XYLT; protein xylosyltransferase [EC:2.4.2.26]; K00771	xylosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:15517]
ENSG00000064961	69.53	71.91	65.78	62.21	67.48	70.66	0.0587523757973378	6.38040988753406	0.395212953037315	0.759220171342002	19:3572776-3579088:+	HMG20B	17;GO:0003677,molecular_function DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007596,biological_process blood coagulation;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016604,cellular_component nuclear body;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0046982,molecular_function protein heterodimerization activity	NA	high mobility group 20B [Source:HGNC Symbol%3BAcc:HGNC:5002]
ENSG00000188452	0.84	0.57	0.79	0.54	0.36	0.88	0.327126521410162	0.354648868199718	0.39526575708011	0.759220171342002	2:181536675-181680665:-	CERKL	15;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0003951,molecular_function NAD+ kinase activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0046625,molecular_function sphingolipid binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	ceramide kinase like [Source:HGNC Symbol%3BAcc:HGNC:21699]
ENSG00000156232	9.31	8.98	8.49	9.72	8.87	9.85	-0.0760585453652384	4.49308550782232	0.395302359801035	0.759220171342002	15:82809627-82836108:+	WHAMM	23;GO:0000139,cellular_component Golgi membrane;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007015,biological_process actin filament organization;GO:0007050,biological_process cell cycle arrest;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0017049,molecular_function GTP-Rho binding;GO:0030032,biological_process lamellipodium assembly;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0048041,biological_process focal adhesion assembly;GO:0051127,biological_process positive regulation of actin nucleation;GO:0071933,molecular_function Arp2/3 complex binding;GO:0090527,biological_process actin filament reorganization;GO:0097320,biological_process membrane tubulation	NA	WAS protein homolog associated with actin%2C golgi membranes and microtubules [Source:HGNC Symbol%3BAcc:HGNC:30493]
ENSG00000197479	0.47	0.68	0.55	0.53	0.38	0.47	0.287307494650606	0.452894407290697	0.395433813689678	0.759220171342002	5:141199581-141203779:+	PCDHB11	11;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0007416,biological_process synapse assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NA	protocadherin beta 11 [Source:HGNC Symbol%3BAcc:HGNC:8682]
ENSG00000099991	13.48	15.02	14.13	13.85	13.86	13.57	0.0562691311310478	6.54812465044798	0.395511613611187	0.759220171342002	22:24011191-24178628:+	CABIN1	10;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016235,cellular_component aggresome;GO:0016569,biological_process covalent chromatin modification;GO:0031491,molecular_function nucleosome binding;GO:0043086,biological_process negative regulation of catalytic activity	NA	calcineurin binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24187]
ENSG00000065518	224.52	241.59	211.42	234.67	232.28	243.99	-0.0598726885449854	6.69501154290464	0.395513987208981	0.759220171342002	3:120596308-120602500:+	NDUFB4	13;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006979,biological_process response to oxidative stress;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain	NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4; K03960	NADH:ubiquinone oxidoreductase subunit B4 [Source:HGNC Symbol%3BAcc:HGNC:7699]
ENSG00000114331	11.32	9.17	11.23	9.20	9.49	11.40	0.0921725493692665	4.75467017312384	0.395587331353079	0.759220171342002	3:195274735-195443078:-	ACAP2	10;GO:0005096,molecular_function GTPase activator activity;GO:0005768,cellular_component endosome;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0036010,biological_process protein localization to endosome;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:1990090,biological_process cellular response to nerve growth factor stimulus	ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein; K12489	ArfGAP with coiled-coil%2C ankyrin repeat and PH domains 2 [Source:HGNC Symbol%3BAcc:HGNC:16469]
ENSG00000169957	34.62	34.86	37.21	38.36	37.03	36.50	-0.0560412151346429	5.88815997617135	0.39568670103192	0.759220171342002	16:30524000-30526821:-	ZNF768	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 768 [Source:HGNC Symbol%3BAcc:HGNC:26273]
ENSG00000169925	10.23	11.93	13.63	13.36	13.29	11.78	-0.0910062135002025	4.77645883562201	0.395735695851872	0.759220171342002	9:134030304-134068535:-	BRD3	8;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016569,biological_process covalent chromatin modification;GO:0070577,molecular_function lysine-acetylated histone binding	NA	bromodomain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:1104]
ENSG00000153721	19.60	20.15	23.34	21.09	22.82	22.97	-0.0712087704497274	5.18087679888302	0.395884968448924	0.759220171342002	6:154387503-154510659:-	CNKSR3	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0009966,biological_process regulation of signal transduction;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0016020,cellular_component membrane;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:2000651,biological_process positive regulation of sodium ion transmembrane transporter activity	NA	CNKSR family member 3 [Source:HGNC Symbol%3BAcc:HGNC:23034]
ENSG00000099904	18.02	16.34	15.68	15.55	16.66	16.07	0.0654748633527332	5.41409710767429	0.396011302864837	0.759220171342002	22:20129455-20148007:+	ZDHHC8	16;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007626,biological_process locomotory behavior;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034380,biological_process high-density lipoprotein particle assembly;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	zinc finger DHHC-type containing 8 [Source:HGNC Symbol%3BAcc:HGNC:18474]
ENSG00000185947	5.49	6.12	5.97	5.73	6.06	4.71	0.102506601309986	3.77548897742705	0.396041380220183	0.759220171342002	16:31873757-31917357:+	ZNF267	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 267 [Source:HGNC Symbol%3BAcc:HGNC:13060]
ENSG00000169045	333.40	330.75	338.95	341.47	345.34	359.11	-0.0484031191697577	9.0258897008341	0.396047907455837	0.759220171342002	5:179614177-179634784:-	HNRNPH1	18;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008266,molecular_function poly(U) RNA binding;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043484,biological_process regulation of RNA splicing;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	heterogeneous nuclear ribonucleoprotein H1 [Source:HGNC Symbol%3BAcc:HGNC:5041]
ENSG00000119616	84.01	78.56	94.21	91.77	88.34	90.94	-0.0627511113073246	5.74561611784212	0.396103155820821	0.759220171342002	14:74713143-74738620:+	FCF1	10;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480,biological_process endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis	UTP24, FCF1; U3 small nucleolar RNA-associated protein 24; K14566	FCF1%2C rRNA-processing protein [Source:HGNC Symbol%3BAcc:HGNC:20220]
ENSG00000151718	12.31	11.14	12.06	11.91	11.26	11.18	0.063418490958375	5.47113269707555	0.396108604820634	0.759220171342002	4:183099292-183320777:+	WWC2	6;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005829,cellular_component cytosol;GO:0019900,molecular_function kinase binding;GO:0032947,molecular_function protein complex scaffold;GO:0035331,biological_process negative regulation of hippo signaling;GO:0046621,biological_process negative regulation of organ growth	NA	WW and C2 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24148]
ENSG00000206562	17.19	16.64	18.34	19.40	17.52	18.57	-0.0742827181833771	4.45560437852262	0.396126954187355	0.759220171342002	3:15381274-15440566:-	METTL6	4;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	methyltransferase like 6 [Source:HGNC Symbol%3BAcc:HGNC:28343]
ENSG00000160310	60.66	64.63	62.26	59.28	63.33	59.28	0.0549843082483769	6.76052264791977	0.396153485166673	0.759220171342002	21:46635166-46665124:+	PRMT2	36;GO:0003713,molecular_function transcription coactivator activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006479,biological_process protein methylation;GO:0007165,biological_process signal transduction;GO:0008168,molecular_function methyltransferase activity;GO:0008469,molecular_function histone-arginine N-methyltransferase activity;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0019919,biological_process peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0030331,molecular_function estrogen receptor binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032259,biological_process methylation;GO:0033142,molecular_function progesterone receptor binding;GO:0034969,biological_process histone arginine methylation;GO:0035189,cellular_component Rb-E2F complex;GO:0035242,molecular_function protein-arginine omega-N asymmetric methyltransferase activity;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0042054,molecular_function histone methyltransferase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0042974,molecular_function retinoic acid receptor binding;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0048588,biological_process developmental cell growth;GO:0050681,molecular_function androgen receptor binding;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	protein arginine methyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:5186]
ENSG00000127481	27.64	25.73	27.79	27.02	26.05	25.89	0.051628916516341	8.73624714683568	0.396294313457414	0.759220171342002	1:19074505-19210276:-	UBR4	22;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0035579,cellular_component specific granule membrane;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane	UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]; K10691	ubiquitin protein ligase E3 component n-recognin 4 [Source:HGNC Symbol%3BAcc:HGNC:30313]
ENSG00000060642	18.19	17.64	16.82	19.39	18.51	17.83	-0.0695661664664095	4.74897104185938	0.396304646705166	0.759220171342002	1:26787471-26798398:+	PIGV	13;GO:0000030,molecular_function mannosyltransferase activity;GO:0004376,molecular_function glycolipid mannosyltransferase activity;GO:0004584,molecular_function dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0031501,cellular_component mannosyltransferase complex;GO:0097502,biological_process mannosylation	PIGV; GPI mannosyltransferase 2 [EC:2.4.1.-]; K07542	phosphatidylinositol glycan anchor biosynthesis class V [Source:HGNC Symbol%3BAcc:HGNC:26031]
ENSG00000132953	3.56	3.51	4.20	3.62	3.34	3.66	0.100519114737712	3.67536101636463	0.396307982899018	0.759220171342002	13:20777328-20903048:-	XPO4	12;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0046827,biological_process positive regulation of protein export from nucleus	NA	exportin 4 [Source:HGNC Symbol%3BAcc:HGNC:17796]
ENSG00000148814	6.05	7.50	6.51	7.05	5.35	6.22	0.109520944455237	3.53776193806658	0.396320149033984	0.759220171342002	10:132332153-132379918:+	LRRC27	2;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction	NA	leucine rich repeat containing 27 [Source:HGNC Symbol%3BAcc:HGNC:29346]
ENSG00000166197	31.40	33.78	32.41	30.72	31.69	32.22	0.0539417401498832	6.09579372023567	0.396391657913837	0.759220171342002	10:102152175-102163871:+	NOLC1	19;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0001042,molecular_function RNA polymerase I core binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006417,biological_process regulation of translation;GO:0007000,biological_process nucleolus organization;GO:0007049,biological_process cell cycle;GO:0014029,biological_process neural crest formation;GO:0014032,biological_process neural crest cell development;GO:0015030,cellular_component Cajal body;GO:0046982,molecular_function protein heterodimerization activity	NA	nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:15608]
ENSG00000184232	46.14	47.72	53.02	46.44	48.43	46.71	0.0658886444786217	5.30558798095011	0.39643928949751	0.759220171342002	11:120210766-120230332:+	OAF	1;GO:0070062,cellular_component extracellular exosome	NA	out at first homolog [Source:HGNC Symbol%3BAcc:HGNC:28752]
ENSG00000087191	78.35	81.42	72.59	84.63	78.77	80.44	-0.0593680875563618	6.62697941951487	0.396459131240493	0.759220171342002	17:63827151-63832026:+	PSMC5	60;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008134,molecular_function transcription factor binding;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017025,molecular_function TBP-class protein binding;GO:0022624,cellular_component proteasome accessory complex;GO:0030163,biological_process protein catabolic process;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031531,molecular_function thyrotropin-releasing hormone receptor binding;GO:0031595,cellular_component nuclear proteasome complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0036402,molecular_function proteasome-activating ATPase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0050804,biological_process modulation of synaptic transmission;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090261,biological_process positive regulation of inclusion body assembly;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0098794,cellular_component postsynapse;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMC5, RPT6; 26S proteasome regulatory subunit T6; K03066	proteasome 26S subunit%2C ATPase 5 [Source:HGNC Symbol%3BAcc:HGNC:9552]
ENSG00000198746	8.46	8.14	8.63	10.31	9.50	7.60	-0.103242099036137	3.84584409546949	0.396471633277726	0.759220171342002	1:26890487-26900466:-	GPATCH3	2;GO:0003676,molecular_function nucleic acid binding;GO:0008150,biological_process biological_process	NA	G-patch domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25720]
ENSG00000135040	23.88	20.95	22.59	23.70	21.71	25.90	-0.0667721627211705	5.66296593659169	0.396521740982051	0.759220171342002	9:85941145-86022298:+	NAA35	8;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0006474,biological_process N-terminal protein amino acid acetylation;GO:0031417,cellular_component NatC complex;GO:0043066,biological_process negative regulation of apoptotic process;GO:0048659,biological_process smooth muscle cell proliferation	NA	N(alpha)-acetyltransferase 35%2C NatC auxiliary subunit [Source:HGNC Symbol%3BAcc:HGNC:24340]
ENSG00000183735	20.09	16.04	19.72	18.21	17.65	17.78	0.0765349686584978	5.32821529021766	0.396794381266012	0.759625023851791	12:64451879-64502108:+	TBK1	41;GO:0000166,molecular_function nucleotide binding;GO:0002218,biological_process activation of innate immune response;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0009615,biological_process response to virus;GO:0010008,cellular_component endosome membrane;GO:0010629,biological_process negative regulation of gene expression;GO:0016032,biological_process viral process;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0032479,biological_process regulation of type I interferon production;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032606,biological_process type I interferon production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044565,biological_process dendritic cell proliferation;GO:0045087,biological_process innate immune response;GO:0045359,biological_process positive regulation of interferon-beta biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051219,molecular_function phosphoprotein binding;GO:0051607,biological_process defense response to virus;GO:1901214,biological_process regulation of neuron death;GO:1904417,biological_process positive regulation of xenophagy	TBK1; TANK-binding kinase 1 [EC:2.7.11.10]; K05410	TANK binding kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:11584]
ENSG00000177685	5.66	5.59	5.47	6.63	5.70	5.99	-0.119868709372693	2.83900943708112	0.396946411231914	0.759798890149845	11:826143-831991:+	CRACR2B	6;GO:0002115,biological_process store-operated calcium entry;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0034613,biological_process cellular protein localization;GO:2001256,biological_process regulation of store-operated calcium entry	NA	calcium release activated channel regulator 2B [Source:HGNC Symbol%3BAcc:HGNC:28703]
ENSG00000213676	59.66	59.71	63.93	62.51	66.56	62.93	-0.0545158789646099	7.06194978646453	0.397068689986367	0.759915764539126	6:32098175-32128253:-	ATF6B	29;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006986,biological_process response to unfolded protein;GO:0007165,biological_process signal transduction;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032993,cellular_component protein-DNA complex;GO:0035497,molecular_function cAMP response element binding;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta; K09049	activating transcription factor 6 beta [Source:HGNC Symbol%3BAcc:HGNC:2349]
ENSG00000187105	0.78	0.78	0.81	0.46	0.71	0.87	0.218728572438151	1.27448711099836	0.397132222752934	0.759920191310647	14:73478483-73558947:-	HEATR4	NA	NA	HEAT repeat containing 4 [Source:HGNC Symbol%3BAcc:HGNC:16761]
ENSG00000164654	14.96	14.16	13.43	12.72	14.27	13.98	0.0664686184296183	5.19826222789019	0.397330029699834	0.760077191441157	7:7566871-7608929:+	MIOS	8;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0016020,cellular_component membrane;GO:0032008,biological_process positive regulation of TOR signaling;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034629,biological_process cellular protein complex localization;GO:0061700,cellular_component GATOR2 complex	NA	meiosis regulator for oocyte development [Source:HGNC Symbol%3BAcc:HGNC:21905]
ENSG00000158467	8.82	8.09	7.64	8.07	7.31	7.92	0.0883340500021205	4.03355215158986	0.397388717202909	0.760077191441157	7:129225022-129430211:+	AHCYL2	10;GO:0004013,molecular_function adenosylhomocysteinase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006730,biological_process one-carbon metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0033353,biological_process S-adenosylmethionine cycle;GO:0043005,cellular_component neuron projection;GO:0043231,cellular_component intracellular membrane-bounded organelle	E3.3.1.1, ahcY; adenosylhomocysteinase [EC:3.3.1.1]; K01251	adenosylhomocysteinase like 2 [Source:HGNC Symbol%3BAcc:HGNC:22204]
ENSG00000135249	13.53	13.87	14.74	13.17	13.84	13.65	0.0641425495394112	5.06358188679574	0.397484762181719	0.760077191441157	7:105532084-105567677:+	RINT1	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007049,biological_process cell cycle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0048193,biological_process Golgi vesicle transport;GO:0060628,biological_process regulation of ER to Golgi vesicle-mediated transport;GO:0070939,cellular_component Dsl1p complex;GO:1902504,biological_process regulation of signal transduction involved in mitotic G2 DNA damage checkpoint	NA	RAD50 interactor 1 [Source:HGNC Symbol%3BAcc:HGNC:21876]
ENSG00000159399	50.40	48.88	51.02	54.21	49.38	53.81	-0.0544458082528439	7.14316209802037	0.397599886096077	0.760077191441157	2:74833980-74893359:+	HK2	37;GO:0000166,molecular_function nucleotide binding;GO:0001678,biological_process cellular glucose homeostasis;GO:0002931,biological_process response to ischemia;GO:0003824,molecular_function catalytic activity;GO:0004340,molecular_function glucokinase activity;GO:0004396,molecular_function hexokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005536,molecular_function glucose binding;GO:0005623,cellular_component cell;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006096,biological_process glycolytic process;GO:0007595,biological_process lactation;GO:0008152,biological_process metabolic process;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0008865,molecular_function fructokinase activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019158,molecular_function mannokinase activity;GO:0019318,biological_process hexose metabolic process;GO:0035795,biological_process negative regulation of mitochondrial membrane permeability;GO:0046324,biological_process regulation of glucose import;GO:0046835,biological_process carbohydrate phosphorylation;GO:0051156,biological_process glucose 6-phosphate metabolic process;GO:0061621,biological_process canonical glycolysis;GO:0072655,biological_process establishment of protein localization to mitochondrion;GO:0072656,biological_process maintenance of protein location in mitochondrion;GO:1904925,biological_process positive regulation of mitophagy in response to mitochondrial depolarization;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	HK; hexokinase [EC:2.7.1.1]; K00844	hexokinase 2 [Source:HGNC Symbol%3BAcc:HGNC:4923]
ENSG00000077454	9.69	9.06	8.25	8.25	8.71	8.76	0.0815032596376122	4.25210107518621	0.397607085775707	0.760077191441157	7:100574010-100586153:-	LRCH4	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016605,cellular_component PML body;GO:0045199,biological_process maintenance of epithelial cell apical/basal polarity	NA	leucine rich repeats and calponin homology domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:6691]
ENSG00000114529	5.05	5.29	3.37	5.22	5.07	5.10	-0.164941041079261	2.38440267891912	0.397687509848067	0.760077191441157	3:112086334-112131004:+	C3orf52	5;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 3 open reading frame 52 [Source:HGNC Symbol%3BAcc:HGNC:26255]
ENSG00000127870	18.90	19.86	19.95	16.80	20.11	19.50	0.0679820699936785	5.3067975050341	0.397741656280686	0.760077191441157	13:26132114-26222493:-	RNF6	24;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0030424,cellular_component axon;GO:0030517,biological_process negative regulation of axon extension;GO:0031965,cellular_component nuclear membrane;GO:0042995,cellular_component cell projection;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044314,biological_process protein K27-linked ubiquitination;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0085020,biological_process protein K6-linked ubiquitination	NA	ring finger protein 6 [Source:HGNC Symbol%3BAcc:HGNC:10069]
ENSG00000140691	2.52	2.29	2.54	2.82	2.81	2.38	-0.106380724259535	3.16007277215497	0.397742009851091	0.760077191441157	16:31458079-31467166:+	ARMC5	4;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion	NA	armadillo repeat containing 5 [Source:HGNC Symbol%3BAcc:HGNC:25781]
ENSG00000078687	1.41	1.62	1.55	1.36	1.38	1.53	0.107325599417614	3.12885712827468	0.397765361766032	0.760077191441157	17:77959239-78108835:+	TNRC6C	15;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0031047,biological_process gene silencing by RNA;GO:0035194,biological_process posttranscriptional gene silencing by RNA;GO:0035195,biological_process gene silencing by miRNA;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	NA	trinucleotide repeat containing 6C [Source:HGNC Symbol%3BAcc:HGNC:29318]
ENSG00000165555	0.52	1.06	1.23	0.56	0.99	0.65	0.353697147983516	0.0555308536497639	0.397895517897329	0.760194813186695	14:77394020-77423517:-	NOXRED1	7;GO:0003674,molecular_function molecular_function;GO:0004735,molecular_function pyrroline-5-carboxylate reductase activity;GO:0005575,cellular_component cellular_component;GO:0006561,biological_process proline biosynthetic process;GO:0008150,biological_process biological_process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	NADP dependent oxidoreductase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20487]
ENSG00000005302	12.59	14.12	14.32	13.39	12.71	13.11	0.0734671092149342	4.52014888853066	0.397970920200512	0.760194813186695	X:11758158-11775753:+	MSL3	15;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006342,biological_process chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0035064,molecular_function methylated histone binding;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0043968,biological_process histone H2A acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0072487,cellular_component MSL complex	NA	MSL complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:7370]
ENSG00000168899	29.43	26.64	28.76	24.96	27.24	27.68	0.103558550585711	3.28153150921562	0.398010641335723	0.760194813186695	2:85584407-85593412:+	VAMP5	25;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0007519,biological_process skeletal muscle tissue development;GO:0009986,cellular_component cell surface;GO:0012505,cellular_component endomembrane system;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030154,biological_process cell differentiation;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031301,cellular_component integral component of organelle membrane;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	VAMP5; vesicle-associated membrane protein 5; K08514	vesicle associated membrane protein 5 [Source:HGNC Symbol%3BAcc:HGNC:12646]
ENSG00000110344	17.71	18.05	18.31	18.93	18.78	18.85	-0.0535954725005788	5.89602914904547	0.398260520955035	0.760555053325362	11:118359584-118399211:+	UBE4A	11;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity	UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]; K10596	ubiquitination factor E4A [Source:HGNC Symbol%3BAcc:HGNC:12499]
ENSG00000129646	0.93	0.85	1.06	0.94	1.17	1.06	-0.137664763563655	2.57251975120933	0.398493921441373	0.76062288540659	17:76274048-76307998:-	QRICH2	NA	NA	glutamine rich 2 [Source:HGNC Symbol%3BAcc:HGNC:25326]
ENSG00000155749	1.64	1.43	1.76	2.24	1.42	2.00	-0.207450257213101	1.32570901346764	0.398597429307192	0.76062288540659	2:201288270-201357398:-	ALS2CR12	5;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0042995,cellular_component cell projection	NA	amyotrophic lateral sclerosis 2 chromosome region 12 [Source:HGNC Symbol%3BAcc:HGNC:14439]
ENSG00000167986	91.70	106.58	91.78	90.81	99.81	88.96	0.064182148339443	8.36176914186789	0.398600088802704	0.76062288540659	11:61299450-61342596:-	DDB1	44;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010498,biological_process proteasomal protein catabolic process;GO:0016032,biological_process viral process;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0030674,molecular_function protein binding, bridging;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0031465,cellular_component Cul4B-RING E3 ubiquitin ligase complex;GO:0032403,molecular_function protein complex binding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0035518,biological_process histone H2A monoubiquitination;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0045070,biological_process positive regulation of viral genome replication;GO:0046726,biological_process positive regulation by virus of viral protein levels in host cell;GO:0051702,biological_process interaction with symbiont;GO:0070062,cellular_component extracellular exosome;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070914,biological_process UV-damage excision repair;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex;GO:0097602,molecular_function cullin family protein binding;GO:1901990,biological_process regulation of mitotic cell cycle phase transition;GO:1902188,biological_process positive regulation of viral release from host cell	DDB1; DNA damage-binding protein 1; K10610	damage specific DNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2717]
ENSG00000167113	29.31	30.28	26.52	26.83	28.79	26.90	0.069958317742224	4.80166845035719	0.398644347839823	0.76062288540659	9:128322535-128334072:+	COQ4	6;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0043234,cellular_component protein complex	NA	coenzyme Q4 [Source:HGNC Symbol%3BAcc:HGNC:19693]
ENSG00000176102	20.24	21.32	21.82	21.76	21.30	23.47	-0.0600120430155593	5.72792049000365	0.398718463764735	0.76062288540659	11:33077187-33162371:-	CSTF3	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006379,biological_process mRNA cleavage;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0031124,biological_process mRNA 3'-end processing	CSTF3, RNA14; cleavage stimulation factor subunit 3; K14408	cleavage stimulation factor subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:2485]
ENSG00000090924	7.90	6.81	7.84	7.45	6.96	7.29	0.0728995442967231	4.99103136848539	0.398721196848158	0.76062288540659	19:39412584-39428415:+	PLEKHG2	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005829,cellular_component cytosol;GO:0030833,biological_process regulation of actin filament polymerization;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	pleckstrin homology and RhoGEF domain containing G2 [Source:HGNC Symbol%3BAcc:HGNC:29515]
ENSG00000248712	1.68	1.52	2.10	2.38	1.81	2.34	-0.275229430592355	0.491079580578724	0.398724975053628	0.76062288540659	11:119189637-119196769:-	CCDC153	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 153 [Source:HGNC Symbol%3BAcc:HGNC:27446]
ENSG00000187801	3.31	3.46	3.26	3.69	3.65	3.73	-0.134824852875323	2.53322919597209	0.398907516856648	0.760745556187455	1:40450101-40463718:+	ZFP69B	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP69 zinc finger protein B [Source:HGNC Symbol%3BAcc:HGNC:28053]
ENSG00000138382	66.51	61.65	61.75	59.40	56.62	67.02	0.0653486216190639	5.62214702279465	0.398911852511411	0.760745556187455	2:169810080-169824931:-	METTL5	4;GO:0003676,molecular_function nucleic acid binding;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	methyltransferase like 5 [Source:HGNC Symbol%3BAcc:HGNC:25006]
ENSG00000122882	14.17	13.28	14.32	14.04	15.93	14.27	-0.0674254502496707	4.94725427557303	0.399465204498589	0.761683806980181	10:73130154-73169055:-	ECD	17;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008283,biological_process cell proliferation;GO:0008380,biological_process RNA splicing;GO:0035035,molecular_function histone acetyltransferase binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0097255,cellular_component R2TP complex;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	NA	ecdysoneless cell cycle regulator [Source:HGNC Symbol%3BAcc:HGNC:17029]
ENSG00000125319	3.57	3.45	3.75	3.90	4.34	3.59	-0.1168206375041	2.90149578530075	0.399575472846975	0.761777045684151	17:44141905-44162476:+	C17orf53	NA	NA	chromosome 17 open reading frame 53 [Source:HGNC Symbol%3BAcc:HGNC:28460]
ENSG00000130193	6.45	9.95	7.67	6.72	8.87	5.52	0.187827411609696	2.25929691033627	0.399882727719892	0.762245746189653	8:142727202-142736927:+	THEM6	1;GO:0005576,cellular_component extracellular region	NA	thioesterase superfamily member 6 [Source:HGNC Symbol%3BAcc:HGNC:29656]
ENSG00000143013	111.72	101.36	100.96	105.58	95.76	102.28	0.0621512987658422	5.67702274542049	0.399988066171612	0.76228393424493	1:87328467-87348923:+	LMO4	22;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001843,biological_process neural tube closure;GO:0003281,biological_process ventricular septum development;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0021514,biological_process ventral spinal cord interneuron differentiation;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021527,biological_process spinal cord association neuron differentiation;GO:0030334,biological_process regulation of cell migration;GO:0031252,cellular_component cell leading edge;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0033674,biological_process positive regulation of kinase activity;GO:0042659,biological_process regulation of cell fate specification;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048538,biological_process thymus development;GO:0050865,biological_process regulation of cell activation	NA	LIM domain only 4 [Source:HGNC Symbol%3BAcc:HGNC:6644]
ENSG00000239704	6.51	7.75	8.39	7.88	9.48	8.33	-0.173248060029764	1.93580730728937	0.400137331368842	0.76228393424493	17:15436014-15503608:-	CDRT4	1;GO:0005515,molecular_function protein binding	NA	CMT1A duplicated region transcript 4 [Source:HGNC Symbol%3BAcc:HGNC:14383]
ENSG00000141933	8.12	8.46	9.05	7.57	9.15	6.95	0.128872471313207	2.8657478270422	0.400143245621009	0.76228393424493	19:507496-519654:+	TPGS1	21;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007268,biological_process chemical synaptic transmission;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007288,biological_process sperm axoneme assembly;GO:0008017,molecular_function microtubule binding;GO:0015631,molecular_function tubulin binding;GO:0018095,biological_process protein polyglutamylation;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030534,biological_process adult behavior;GO:0031514,cellular_component motile cilium;GO:0042995,cellular_component cell projection;GO:0051648,biological_process vesicle localization;GO:0070740,molecular_function tubulin-glutamic acid ligase activity	NA	tubulin polyglutamylase complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:25058]
ENSG00000176692	1.69	1.59	1.96	1.54	1.82	2.81	-0.222547122155768	1.6025924234513	0.400250040465796	0.76228393424493	16:86567250-86569728:+	FOXC2	62;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001568,biological_process blood vessel development;GO:0001569,biological_process patterning of blood vessels;GO:0001656,biological_process metanephros development;GO:0001657,biological_process ureteric bud development;GO:0001756,biological_process somitogenesis;GO:0001822,biological_process kidney development;GO:0001945,biological_process lymph vessel development;GO:0001946,biological_process lymphangiogenesis;GO:0001974,biological_process blood vessel remodeling;GO:0003007,biological_process heart morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007498,biological_process mesoderm development;GO:0007507,biological_process heart development;GO:0008283,biological_process cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009725,biological_process response to hormone;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0014032,biological_process neural crest cell development;GO:0016604,cellular_component nuclear body;GO:0030154,biological_process cell differentiation;GO:0030199,biological_process collagen fibril organization;GO:0031490,molecular_function chromatin DNA binding;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0035050,biological_process embryonic heart tube development;GO:0035470,biological_process positive regulation of vascular wound healing;GO:0042802,molecular_function identical protein binding;GO:0043010,biological_process camera-type eye development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046620,biological_process regulation of organ growth;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048341,biological_process paraxial mesoderm formation;GO:0048343,biological_process paraxial mesodermal cell fate commitment;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048844,biological_process artery morphogenesis;GO:0050880,biological_process regulation of blood vessel size;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0072011,biological_process glomerular endothelium development;GO:0072112,biological_process glomerular visceral epithelial cell differentiation;GO:0072144,biological_process glomerular mesangial cell development;GO:0090050,biological_process positive regulation of cell migration involved in sprouting angiogenesis;GO:1902257,biological_process negative regulation of apoptotic process involved in outflow tract morphogenesis;GO:1990841,molecular_function promoter-specific chromatin binding	NA	forkhead box C2 [Source:HGNC Symbol%3BAcc:HGNC:3801]
ENSG00000169435	3.55	3.32	4.47	4.61	3.68	4.51	-0.155765610523613	2.2694990006543	0.400298813730305	0.76228393424493	4:73571549-73620631:-	RASSF6	4;GO:0005515,molecular_function protein binding;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0042981,biological_process regulation of apoptotic process	RASSF6; Ras association domain-containing protein 6; K09854	Ras association domain family member 6 [Source:HGNC Symbol%3BAcc:HGNC:20796]
ENSG00000110851	11.83	11.04	11.93	12.82	12.39	11.63	-0.0659508284832565	4.86516042460041	0.400349632496007	0.76228393424493	12:107732865-107761272:-	PRDM4	21;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0043985,biological_process histone H4-R3 methylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1990226,molecular_function histone methyltransferase binding	PRDM4; PR domain zinc finger protein 4; K12463	PR/SET domain 4 [Source:HGNC Symbol%3BAcc:HGNC:9348]
ENSG00000239900	47.42	46.40	46.90	50.23	49.28	47.77	-0.0534801825309123	6.51374189635073	0.400424674498564	0.76228393424493	22:40346499-40390463:+	ADSL	20;GO:0001666,biological_process response to hypoxia;GO:0003824,molecular_function catalytic activity;GO:0004018,molecular_function N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006163,biological_process purine nucleotide metabolic process;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006167,biological_process AMP biosynthetic process;GO:0006189,biological_process 'de novo' IMP biosynthetic process;GO:0007584,biological_process response to nutrient;GO:0009060,biological_process aerobic respiration;GO:0009152,biological_process purine ribonucleotide biosynthetic process;GO:0009156,biological_process ribonucleoside monophosphate biosynthetic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0014850,biological_process response to muscle activity;GO:0016829,molecular_function lyase activity;GO:0042594,biological_process response to starvation;GO:0044208,biological_process 'de novo' AMP biosynthetic process;GO:0051262,biological_process protein tetramerization;GO:0070626,molecular_function (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]; K01756	adenylosuccinate lyase [Source:HGNC Symbol%3BAcc:HGNC:291]
ENSG00000197442	7.98	7.98	7.79	6.67	6.42	9.26	0.0973978383576726	4.99328814188169	0.400426258945698	0.76228393424493	6:136557046-136792518:-	MAP3K5	58;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0000287,molecular_function magnesium ion binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0002931,biological_process response to ischemia;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007254,biological_process JNK cascade;GO:0007257,biological_process activation of JUN kinase activity;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0009897,cellular_component external side of plasma membrane;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0010941,biological_process regulation of cell death;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0038066,biological_process p38MAPK cascade;GO:0042060,biological_process wound healing;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045087,biological_process innate immune response;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0051403,biological_process stress-activated MAPK cascade;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0072577,biological_process endothelial cell apoptotic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097300,biological_process programmed necrotic cell death;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1901216,biological_process positive regulation of neuron death;GO:1902170,biological_process cellular response to reactive nitrogen species;GO:1902911,cellular_component protein kinase complex;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1990604,cellular_component IRE1-TRAF2-ASK1 complex	MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]; K04426	mitogen-activated protein kinase kinase kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:6857]
ENSG00000037749	16.65	13.73	17.21	16.62	16.13	18.45	-0.0854129702271651	4.17981282032678	0.400520386864681	0.76228393424493	5:154038905-154220478:+	MFAP3	4;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	microfibril associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:7034]
ENSG00000107281	37.34	33.68	40.30	33.12	34.10	39.62	0.0735459242838494	5.6551605600689	0.400536333626322	0.76228393424493	9:137039469-137046203:-	NPDC1	5;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050776,biological_process regulation of immune response	NA	neural proliferation%2C differentiation and control 1 [Source:HGNC Symbol%3BAcc:HGNC:7899]
ENSG00000151247	69.33	75.71	66.83	67.82	72.31	64.23	0.0612944376610307	6.00474809263046	0.40057827302664	0.76228393424493	4:98871683-98930637:-	EIF4E	34;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000339,molecular_function RNA cap binding;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001662,biological_process behavioral fear response;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005845,cellular_component mRNA cap binding complex;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016032,biological_process viral process;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex;GO:0016442,cellular_component RISC complex;GO:0017148,biological_process negative regulation of translation;GO:0019827,biological_process stem cell population maintenance;GO:0019899,molecular_function enzyme binding;GO:0030324,biological_process lung development;GO:0031370,molecular_function eukaryotic initiation factor 4G binding;GO:0033391,cellular_component chromatoid body;GO:0043234,cellular_component protein complex;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0070491,molecular_function repressing transcription factor binding;GO:0071549,biological_process cellular response to dexamethasone stimulus	EIF4E; translation initiation factor 4E; K03259	eukaryotic translation initiation factor 4E [Source:HGNC Symbol%3BAcc:HGNC:3287]
ENSG00000175550	174.68	182.87	177.06	193.54	175.65	190.72	-0.0559736200685565	6.86088103180372	0.400761794094255	0.762516270706926	11:65919256-65921561:+	DRAP1	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042802,molecular_function identical protein binding;GO:0046982,molecular_function protein heterodimerization activity	NA	DR1 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3019]
ENSG00000183255	225.28	215.05	213.86	205.96	220.29	210.05	0.0521244236935652	7.53166847257609	0.400851583370079	0.762570222892382	21:44849584-44873903:-	PTTG1IP	14;GO:0002039,molecular_function p53 binding;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006606,biological_process protein import into nucleus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0070062,cellular_component extracellular exosome;GO:1902254,biological_process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:1903364,biological_process positive regulation of cellular protein catabolic process	NA	PTTG1 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:13524]
ENSG00000018408	57.06	57.84	56.76	57.16	61.40	61.03	-0.0540185758943819	6.25588123102553	0.400996084982089	0.762702630291065	3:149517234-149736714:-	WWTR1	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001649,biological_process osteoblast differentiation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0017145,biological_process stem cell division;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0032835,biological_process glomerulus development;GO:0035264,biological_process multicellular organism growth;GO:0035329,biological_process hippo signaling;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0042803,molecular_function protein homodimerization activity;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048762,biological_process mesenchymal cell differentiation;GO:0060271,biological_process cilium morphogenesis;GO:0060390,biological_process regulation of SMAD protein import into nucleus;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0060993,biological_process kidney morphogenesis;GO:0072307,biological_process regulation of metanephric nephron tubule epithelial cell differentiation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	WWTR1, TAZ; WW domain-containing transcription regulator protein 1; K16820	WW domain containing transcription regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:24042]
ENSG00000161533	10.52	11.10	11.31	11.31	10.38	9.84	0.0740325743175456	4.64525997234616	0.401069449306268	0.762702630291065	17:75941506-75979363:-	ACOX1	34;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0003997,molecular_function acyl-CoA oxidase activity;GO:0005102,molecular_function receptor binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0005886,cellular_component plasma membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006693,biological_process prostaglandin metabolic process;GO:0007283,biological_process spermatogenesis;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019395,biological_process fatty acid oxidation;GO:0030165,molecular_function PDZ domain binding;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0047485,molecular_function protein N-terminus binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase [EC:1.3.3.6]; K00232	acyl-CoA oxidase 1 [Source:HGNC Symbol%3BAcc:HGNC:119]
ENSG00000112210	20.36	22.18	23.19	22.22	19.09	20.97	0.0869392328782344	3.93668637159311	0.40115736965859	0.762702630291065	6:57186991-57222314:-	RAB23	26;GO:0000045,biological_process autophagosome assembly;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005776,cellular_component autophagosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006968,biological_process cellular defense response;GO:0007275,biological_process multicellular organism development;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042992,biological_process negative regulation of transcription factor import into nucleus;GO:0045335,cellular_component phagocytic vesicle;GO:0046039,biological_process GTP metabolic process;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097094,biological_process craniofacial suture morphogenesis	NA	RAB23%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:14263]
ENSG00000141543	67.65	68.21	67.99	69.29	73.32	70.60	-0.0531714568527511	6.42479829072219	0.401181725120626	0.762702630291065	17:80135213-80147183:-	EIF4A3	55;GO:0000166,molecular_function nucleotide binding;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0008143,molecular_function poly(A) binding;GO:0008306,biological_process associative learning;GO:0008380,biological_process RNA splicing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010629,biological_process negative regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0017148,biological_process negative regulation of translation;GO:0030425,cellular_component dendrite;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031124,biological_process mRNA 3'-end processing;GO:0035145,cellular_component exon-exon junction complex;GO:0035368,molecular_function selenocysteine insertion sequence binding;GO:0035613,molecular_function RNA stem-loop binding;GO:0035640,biological_process exploration behavior;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043025,cellular_component neuronal cell body;GO:0045727,biological_process positive regulation of translation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0051028,biological_process mRNA transport;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0072715,biological_process cellular response to selenite ion;GO:0090394,biological_process negative regulation of excitatory postsynaptic potential;GO:1902415,biological_process regulation of mRNA binding;GO:1904570,biological_process negative regulation of selenocysteine incorporation;GO:1904574,biological_process negative regulation of selenocysteine insertion sequence binding;GO:1990416,biological_process cellular response to brain-derived neurotrophic factor stimulus	EIF4A3, FAL1; ATP-dependent RNA helicase [EC:3.6.4.13]; K13025	eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol%3BAcc:HGNC:18683]
ENSG00000135966	13.55	12.89	13.21	14.13	14.05	13.55	-0.0595562888173649	5.13704941985502	0.401341384028854	0.762702630291065	2:105264390-105330034:-	TGFBRAP1	18;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0033263,cellular_component CORVET complex;GO:0034058,biological_process endosomal vesicle fusion;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046332,molecular_function SMAD binding	NA	transforming growth factor beta receptor associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16836]
ENSG00000105583	170.70	205.21	194.96	192.46	180.45	176.13	0.0647691814130967	5.89829466207374	0.401401851733294	0.762702630291065	19:12668070-12671356:-	WDR83OS	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	WD repeat domain 83 opposite strand [Source:HGNC Symbol%3BAcc:HGNC:30203]
ENSG00000196116	10.87	11.89	10.77	10.14	10.68	11.42	0.0633987145867249	5.17940522394603	0.401409256498977	0.762702630291065	9:97411949-97496125:+	TDRD7	13;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0007283,biological_process spermatogenesis;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0033391,cellular_component chromatoid body;GO:0035770,cellular_component ribonucleoprotein granule;GO:0047485,molecular_function protein N-terminus binding;GO:0070306,biological_process lens fiber cell differentiation	NA	tudor domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:30831]
ENSG00000136451	38.85	35.47	43.13	44.02	39.04	41.12	-0.065531792903117	6.00422737209792	0.401442567659034	0.762702630291065	17:57971546-57988259:-	VEZF1	15;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0001885,biological_process endothelial cell development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006968,biological_process cellular defense response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	vascular endothelial zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:12949]
ENSG00000189283	9.93	9.32	9.68	10.36	6.36	9.25	0.167608151386955	2.06773150999669	0.401534695517158	0.762702630291065	3:59749309-61251459:-	FHIT	21;GO:0000166,molecular_function nucleotide binding;GO:0001650,cellular_component fibrillar center;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006163,biological_process purine nucleotide metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0009117,biological_process nucleotide metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0047710,molecular_function bis(5'-adenosyl)-triphosphatase activity;GO:0070062,cellular_component extracellular exosome;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	FHIT; bis(5'-adenosyl)-triphosphatase [EC:3.6.1.29]; K01522	fragile histidine triad [Source:HGNC Symbol%3BAcc:HGNC:3701]
ENSG00000147679	15.00	15.93	15.70	15.83	15.89	17.95	-0.083797250533544	4.0890868898032	0.401535623052615	0.762702630291065	8:116766502-116849463:+	UTP23	12;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480,biological_process endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070181,molecular_function small ribosomal subunit rRNA binding	NA	UTP23%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:28224]
ENSG00000125843	10.48	8.92	7.61	8.49	8.60	7.50	0.151819747972747	2.40831007210289	0.401597727468141	0.762703884801412	20:3820523-3828837:+	AP5S1	18;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006810,biological_process transport;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0031902,cellular_component late endosome membrane	NA	adaptor related protein complex 5 sigma 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:15875]
ENSG00000204859	10.23	9.58	10.91	9.94	9.99	9.51	0.0791128201752723	4.38401589746952	0.401742551269773	0.762735002706064	1:6580000-6589280:+	ZBTB48	17;GO:0000781,cellular_component chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010833,biological_process telomere maintenance via telomere lengthening;GO:0042802,molecular_function identical protein binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 48 [Source:HGNC Symbol%3BAcc:HGNC:4930]
ENSG00000184209	14.07	14.85	13.78	13.42	12.79	13.91	0.0956379266994602	3.39691702553023	0.401790380839079	0.762735002706064	12:123457640-123473154:+	SNRNP35	14;GO:0000243,cellular_component commitment complex;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0017069,molecular_function snRNA binding;GO:0071011,cellular_component precatalytic spliceosome	NA	small nuclear ribonucleoprotein U11/U12 subunit 35 [Source:HGNC Symbol%3BAcc:HGNC:30852]
ENSG00000104321	12.13	8.74	11.80	10.57	9.37	11.02	0.0952416715786173	5.18461379076761	0.401798451840405	0.762735002706064	8:72019916-72075617:-	TRPA1	30;GO:0005216,molecular_function ion channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009409,biological_process response to cold;GO:0010033,biological_process response to organic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0015267,molecular_function channel activity;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019233,biological_process sensory perception of pain;GO:0032421,cellular_component stereocilium bundle;GO:0034220,biological_process ion transmembrane transport;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0048265,biological_process response to pain;GO:0050896,biological_process response to stimulus;GO:0050955,biological_process thermoception;GO:0050966,biological_process detection of mechanical stimulus involved in sensory perception of pain;GO:0050968,biological_process detection of chemical stimulus involved in sensory perception of pain;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051289,biological_process protein homotetramerization;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0097604,molecular_function temperature-gated cation channel activity	TRPA1, ANKTM1; transient receptor potential cation channel subfamily A member 1; K04984	transient receptor potential cation channel subfamily A member 1 [Source:HGNC Symbol%3BAcc:HGNC:497]
ENSG00000160469	1.20	0.82	1.20	1.28	0.86	0.63	0.250947697333966	1.39028163536032	0.401954149443011	0.762913892513165	19:55282071-55312533:+	BRSK1	34;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007269,biological_process neurotransmitter secretion;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0008021,cellular_component synaptic vesicle;GO:0009411,biological_process response to UV;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030010,biological_process establishment of cell polarity;GO:0030054,cellular_component cell junction;GO:0030182,biological_process neuron differentiation;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0035556,biological_process intracellular signal transduction;GO:0043015,molecular_function gamma-tubulin binding;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0050321,molecular_function tau-protein kinase activity;GO:0051298,biological_process centrosome duplication	NA	BR serine/threonine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:18994]
ENSG00000125257	28.20	29.86	28.22	24.90	30.72	27.50	0.064867152848122	6.8275701930875	0.40207838963612	0.76297441750686	13:95019828-95301446:-	ABCC4	27;GO:0000166,molecular_function nucleotide binding;GO:0002576,biological_process platelet degranulation;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0010033,biological_process response to organic substance;GO:0010243,biological_process response to organonitrogen compound;GO:0014070,biological_process response to organic cyclic compound;GO:0015662,molecular_function ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016404,molecular_function 15-hydroxyprostaglandin dehydrogenase (NAD+) activity;GO:0016887,molecular_function ATPase activity;GO:0031088,cellular_component platelet dense granule membrane;GO:0032310,biological_process prostaglandin secretion;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043225,molecular_function anion transmembrane-transporting ATPase activity;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0055085,biological_process transmembrane transport;GO:0055114,biological_process oxidation-reduction process;GO:0060271,biological_process cilium morphogenesis;GO:0099131,biological_process ATP hydrolysis coupled ion transmembrane transport;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport	ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4; K05673	ATP binding cassette subfamily C member 4 [Source:HGNC Symbol%3BAcc:HGNC:55]
ENSG00000165699	9.92	11.41	11.33	10.79	10.73	9.83	0.0674582889670863	5.25175524498677	0.40210896957463	0.76297441750686	9:132891347-132944633:-	TSC1	63;GO:0001822,biological_process kidney development;GO:0001843,biological_process neural tube closure;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0002250,biological_process adaptive immune response;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006407,biological_process rRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006813,biological_process potassium ion transport;GO:0007050,biological_process cell cycle arrest;GO:0007160,biological_process cell-matrix adhesion;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008344,biological_process adult locomotory behavior;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016242,biological_process negative regulation of macroautophagy;GO:0017148,biological_process negative regulation of translation;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0030027,cellular_component lamellipodium;GO:0030030,biological_process cell projection organization;GO:0030426,cellular_component growth cone;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032794,molecular_function GTPase activating protein binding;GO:0032868,biological_process response to insulin;GO:0033596,cellular_component TSC1-TSC2 complex;GO:0034260,biological_process negative regulation of GTPase activity;GO:0042552,biological_process myelination;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043379,biological_process memory T cell differentiation;GO:0043666,biological_process regulation of phosphoprotein phosphatase activity;GO:0045792,biological_process negative regulation of cell size;GO:0045859,biological_process regulation of protein kinase activity;GO:0046323,biological_process glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0047485,molecular_function protein N-terminus binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050808,biological_process synapse organization;GO:0050821,biological_process protein stabilization;GO:0051087,molecular_function chaperone binding;GO:0051291,biological_process protein heterooligomerization;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051726,biological_process regulation of cell cycle;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0061024,biological_process membrane organization;GO:0090630,biological_process activation of GTPase activity;GO:0090650,biological_process cellular response to oxygen-glucose deprivation;GO:1901214,biological_process regulation of neuron death;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death	TSC1; tuberous sclerosis 1; K07206	tuberous sclerosis 1 [Source:HGNC Symbol%3BAcc:HGNC:12362]
ENSG00000146215	3.75	2.54	2.88	3.04	3.29	1.57	0.251794372324728	1.13183663102582	0.402309581256542	0.763238397086575	6:43299709-43308797:-	CRIP3	2;GO:0005737,cellular_component cytoplasm;GO:0046872,molecular_function metal ion binding	NA	cysteine rich protein 3 [Source:HGNC Symbol%3BAcc:HGNC:17751]
ENSG00000124193	137.48	127.53	133.93	130.15	145.84	142.18	-0.0552928746405555	7.33212103827252	0.402438948185458	0.763367155230148	20:43457927-43464247:+	SRSF6	26;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0010629,biological_process negative regulation of gene expression;GO:0010837,biological_process regulation of keratinocyte proliferation;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0032868,biological_process response to insulin;GO:0036002,molecular_function pre-mRNA binding;GO:0045617,biological_process negative regulation of keratinocyte differentiation;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0060501,biological_process positive regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0060548,biological_process negative regulation of cell death;GO:0061041,biological_process regulation of wound healing;GO:2000675,biological_process negative regulation of type B pancreatic cell apoptotic process	SFRS4_5_6; splicing factor, arginine/serine-rich 4/5/6; K12893	serine and arginine rich splicing factor 6 [Source:HGNC Symbol%3BAcc:HGNC:10788]
ENSG00000196459	13.68	13.53	14.80	13.80	15.25	16.89	-0.117113816819504	3.00891232333699	0.402517089084475	0.763398720673123	X:13712243-13734635:-	TRAPPC2	24;GO:0000139,cellular_component Golgi membrane;GO:0001501,biological_process skeletal system development;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008134,molecular_function transcription factor binding;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044325,molecular_function ion channel binding;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 2 [Source:HGNC Symbol%3BAcc:HGNC:23068]
ENSG00000156110	46.36	45.78	44.29	43.36	47.99	40.15	0.0656955571581946	5.62273806449383	0.402616873003211	0.763436761366951	10:74151184-74709303:+	ADK	20;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004001,molecular_function adenosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006166,biological_process purine ribonucleoside salvage;GO:0006167,biological_process AMP biosynthetic process;GO:0006169,biological_process adenosine salvage;GO:0006175,biological_process dATP biosynthetic process;GO:0009156,biological_process ribonucleoside monophosphate biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0043101,biological_process purine-containing compound salvage;GO:0044209,biological_process AMP salvage;GO:0046872,molecular_function metal ion binding	E2.7.1.20, ADK; adenosine kinase [EC:2.7.1.20]; K00856	adenosine kinase [Source:HGNC Symbol%3BAcc:HGNC:257]
ENSG00000171763	5.92	5.38	4.34	5.03	4.63	4.94	0.108436906689387	3.54791104769161	0.402660152797022	0.763436761366951	15:45402330-45421419:+	SPATA5L1	3;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm	NA	spermatogenesis associated 5 like 1 [Source:HGNC Symbol%3BAcc:HGNC:28762]
ENSG00000125124	32.74	28.50	30.79	30.42	35.26	31.43	-0.0626995556133255	6.09876263367623	0.402783622816634	0.763554231830006	16:56466835-56520283:-	BBS2	46;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007288,biological_process sperm axoneme assembly;GO:0007601,biological_process visual perception;GO:0008104,biological_process protein localization;GO:0010629,biological_process negative regulation of gene expression;GO:0014824,biological_process artery smooth muscle contraction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0021756,biological_process striatum development;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0030030,biological_process cell projection organization;GO:0030534,biological_process adult behavior;GO:0031514,cellular_component motile cilium;GO:0032402,biological_process melanosome transport;GO:0032420,cellular_component stereocilium;GO:0033210,biological_process leptin-mediated signaling pathway;GO:0033365,biological_process protein localization to organelle;GO:0034464,cellular_component BBSome;GO:0036064,cellular_component ciliary basal body;GO:0038108,biological_process negative regulation of appetite by leptin-mediated signaling pathway;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042311,biological_process vasodilation;GO:0042995,cellular_component cell projection;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0044321,biological_process response to leptin;GO:0045444,biological_process fat cell differentiation;GO:0045494,biological_process photoreceptor cell maintenance;GO:0048854,biological_process brain morphogenesis;GO:0050896,biological_process response to stimulus;GO:0051216,biological_process cartilage development;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0060296,biological_process regulation of cilium beat frequency involved in ciliary motility;GO:1903441,biological_process protein localization to ciliary membrane;GO:1905515,biological_process non-motile cilium assembly	NA	Bardet-Biedl syndrome 2 [Source:HGNC Symbol%3BAcc:HGNC:967]
ENSG00000136810	856.48	903.17	821.53	845.70	823.67	840.92	0.051265746219845	8.06384832389027	0.402912027773993	0.763681020118884	9:110243810-110256640:-	TXN	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003723,molecular_function RNA binding;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006662,biological_process glycerol ether metabolic process;GO:0006928,biological_process movement of cell or subcellular component;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008283,biological_process cell proliferation;GO:0009314,biological_process response to radiation;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015037,molecular_function peptide disulfide oxidoreductase activity;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0030091,biological_process protein repair;GO:0032148,biological_process activation of protein kinase B activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033158,biological_process regulation of protein import into nucleus, translocation;GO:0034599,biological_process cellular response to oxidative stress;GO:0043388,biological_process positive regulation of DNA binding;GO:0045454,biological_process cell redox homeostasis;GO:0046826,biological_process negative regulation of protein export from nucleus;GO:0047134,molecular_function protein-disulfide reductase activity;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death	trxA; thioredoxin 1; K03671	thioredoxin [Source:HGNC Symbol%3BAcc:HGNC:12435]
ENSG00000176393	56.81	56.94	58.03	58.88	59.53	61.05	-0.0513923711611136	6.87720701114364	0.403028064689916	0.763784330839074	1:201982371-202006147:+	RNPEP	18;GO:0004177,molecular_function aminopeptidase activity;GO:0004301,molecular_function epoxide hydrolase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0030141,cellular_component secretory granule;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0045776,biological_process negative regulation of blood pressure;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome	NA	arginyl aminopeptidase [Source:HGNC Symbol%3BAcc:HGNC:10078]
ENSG00000151694	39.19	35.79	36.24	38.10	36.89	41.90	-0.0590260557900097	6.57108383992917	0.403181180819344	0.763908802620347	2:9488485-9555792:-	ADAM17	60;GO:0001666,biological_process response to hypoxia;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002446,biological_process neutrophil mediated immunity;GO:0002467,biological_process germinal center formation;GO:0002690,biological_process positive regulation of leukocyte chemotaxis;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005112,molecular_function Notch binding;GO:0005138,molecular_function interleukin-6 receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007155,biological_process cell adhesion;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010820,biological_process positive regulation of T cell chemotaxis;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030165,molecular_function PDZ domain binding;GO:0030183,biological_process B cell differentiation;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0031659,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0032496,biological_process response to lipopolysaccharide;GO:0032587,cellular_component ruffle membrane;GO:0032722,biological_process positive regulation of chemokine production;GO:0033025,biological_process regulation of mast cell apoptotic process;GO:0033077,biological_process T cell differentiation in thymus;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0035313,biological_process wound healing, spreading of epidermal cells;GO:0035625,biological_process epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway;GO:0042493,biological_process response to drug;GO:0045121,cellular_component membrane raft;GO:0045741,biological_process positive regulation of epidermal growth factor-activated receptor activity;GO:0046872,molecular_function metal ion binding;GO:0048536,biological_process spleen development;GO:0048870,biological_process cell motility;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051088,biological_process PMA-inducible membrane protein ectodomain proteolysis;GO:0051272,biological_process positive regulation of cellular component movement;GO:0055099,biological_process response to high density lipoprotein particle	ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]; K06059	ADAM metallopeptidase domain 17 [Source:HGNC Symbol%3BAcc:HGNC:195]
ENSG00000138796	32.13	40.36	31.39	36.72	38.76	34.88	-0.0809247174612642	5.65457981056641	0.403241504302508	0.763908802620347	4:107989713-108035175:+	HADH	17;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0009725,biological_process response to hormone;GO:0014823,biological_process response to activity;GO:0016491,molecular_function oxidoreductase activity;GO:0032868,biological_process response to insulin;GO:0042493,biological_process response to drug;GO:0046676,biological_process negative regulation of insulin secretion;GO:0055114,biological_process oxidation-reduction process;GO:0070403,molecular_function NAD+ binding	HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]; K00022	hydroxyacyl-CoA dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:4799]
ENSG00000020922	20.40	20.47	17.71	21.03	20.39	20.28	-0.065583496458683	5.43962264212893	0.403278368127861	0.763908802620347	11:94415577-94493908:-	MRE11	55;GO:0000014,molecular_function single-stranded DNA endodeoxyribonuclease activity;GO:0000019,biological_process regulation of mitotic recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007004,biological_process telomere maintenance via telomerase;GO:0007062,biological_process sister chromatid cohesion;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0007129,biological_process synapsis;GO:0007131,biological_process reciprocal meiotic recombination;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0016032,biological_process viral process;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0030870,cellular_component Mre11 complex;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0031860,biological_process telomeric 3' overhang formation;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032508,biological_process DNA duplex unwinding;GO:0032876,biological_process negative regulation of DNA endoreduplication;GO:0033674,biological_process positive regulation of kinase activity;GO:0035861,cellular_component site of double-strand break;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045296,molecular_function cadherin binding;GO:0051276,biological_process chromosome organization;GO:0051321,biological_process meiotic cell cycle;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	MRE11; double-strand break repair protein MRE11; K10865	MRE11 homolog%2C double strand break repair nuclease [Source:HGNC Symbol%3BAcc:HGNC:7230]
ENSG00000134313	16.02	15.11	15.37	14.73	16.89	17.28	-0.0603123602200739	6.46864148744391	0.403358356062274	0.763943740280898	2:8721080-8837630:-	KIDINS220	16;GO:0000186,biological_process activation of MAPKK activity;GO:0001701,biological_process in utero embryonic development;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0007399,biological_process nervous system development;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019887,molecular_function protein kinase regulator activity;GO:0030165,molecular_function PDZ domain binding;GO:0038180,biological_process nerve growth factor signaling pathway;GO:0043234,cellular_component protein complex;GO:0045859,biological_process regulation of protein kinase activity;GO:0048813,biological_process dendrite morphogenesis;GO:1990090,biological_process cellular response to nerve growth factor stimulus	KIDINS220, ARMS; ankyrin repeat-rich membrane spanning protein; K12460	kinase D interacting substrate 220 [Source:HGNC Symbol%3BAcc:HGNC:29508]
ENSG00000178222	3.45	2.45	3.06	2.79	3.15	4.25	-0.16354751820524	2.44234329053389	0.403572309688691	0.764227901719986	4:1056249-1113562:-	RNF212	12;GO:0000795,cellular_component synaptonemal complex;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006311,biological_process meiotic gene conversion;GO:0007129,biological_process synapsis;GO:0007131,biological_process reciprocal meiotic recombination;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0046872,molecular_function metal ion binding;GO:0051026,biological_process chiasma assembly;GO:0051321,biological_process meiotic cell cycle	NA	ring finger protein 212 [Source:HGNC Symbol%3BAcc:HGNC:27729]
ENSG00000164574	16.71	17.50	14.96	17.88	16.22	17.91	-0.0734283802074626	5.00017650255096	0.403631525310258	0.764227901719986	5:154190729-154420984:+	GALNT10	12;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 10 [Source:HGNC Symbol%3BAcc:HGNC:19873]
ENSG00000114383	29.80	33.60	32.58	30.03	33.18	26.92	0.0997821899974293	3.58840855924465	0.403801820249318	0.764433734139819	3:50320026-50328251:-	TUSC2	18;GO:0001779,biological_process natural killer cell differentiation;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006909,biological_process phagocytosis;GO:0006954,biological_process inflammatory response;GO:0007049,biological_process cell cycle;GO:0007267,biological_process cell-cell signaling;GO:0008283,biological_process cell proliferation;GO:0032618,biological_process interleukin-15 production;GO:0032700,biological_process negative regulation of interleukin-17 production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0048469,biological_process cell maturation;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0052567,biological_process response to defense-related host reactive oxygen species production;GO:0070945,biological_process neutrophil mediated killing of gram-negative bacterium;GO:0071609,biological_process chemokine (C-C motif) ligand 5 production;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	NA	tumor suppressor candidate 2 [Source:HGNC Symbol%3BAcc:HGNC:17034]
ENSG00000164933	44.32	38.93	40.66	37.79	39.57	42.19	0.0665741612624045	5.26908771623544	0.403894554688768	0.76449269706491	8:103398634-103415189:-	SLC25A32	14;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006544,biological_process glycine metabolic process;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0008517,molecular_function folic acid transporter activity;GO:0015230,molecular_function FAD transmembrane transporter activity;GO:0015884,biological_process folic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0035350,biological_process FAD transmembrane transport;GO:0046655,biological_process folic acid metabolic process;GO:1904947,biological_process folic acid import into mitochondrion	NA	solute carrier family 25 member 32 [Source:HGNC Symbol%3BAcc:HGNC:29683]
ENSG00000198168	57.48	46.75	52.89	64.82	47.28	59.66	-0.110381182562129	3.68706573794426	0.404011805163413	0.764593179644997	11:22813798-22830299:-	SVIP	22;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0010508,biological_process positive regulation of autophagy;GO:0016020,cellular_component membrane;GO:0030667,cellular_component secretory granule membrane;GO:0030868,cellular_component smooth endoplasmic reticulum membrane;GO:0031225,cellular_component anchored component of membrane;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0043312,biological_process neutrophil degranulation;GO:0043621,molecular_function protein self-association;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:1903061,biological_process positive regulation of protein lipidation;GO:1903070,biological_process negative regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol;GO:1904240,biological_process negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly	SVIP; small VCP/p97-interacting protein; K14014	small VCP interacting protein [Source:HGNC Symbol%3BAcc:HGNC:25238]
ENSG00000067955	33.40	30.35	31.83	38.07	31.26	33.02	-0.0830354497796196	4.30202404414737	0.404108226190345	0.764593179644997	16:67029115-67101058:+	CBFB	27;GO:0000209,biological_process protein polyubiquitination;GO:0001503,biological_process ossification;GO:0001649,biological_process osteoblast differentiation;GO:0001959,biological_process regulation of cytokine-mediated signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0030098,biological_process lymphocyte differentiation;GO:0030099,biological_process myeloid cell differentiation;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0045589,biological_process regulation of regulatory T cell differentiation;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048469,biological_process cell maturation;GO:0050855,biological_process regulation of B cell receptor signaling pathway;GO:0060216,biological_process definitive hemopoiesis;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1903506,biological_process regulation of nucleic acid-templated transcription;GO:2000810,biological_process regulation of bicellular tight junction assembly	NA	core-binding factor beta subunit [Source:HGNC Symbol%3BAcc:HGNC:1539]
ENSG00000077348	24.23	24.77	30.67	27.59	25.25	33.33	-0.100151692376798	4.45792078883164	0.404157642951835	0.764593179644997	19:41386373-41397479:-	EXOSC5	25;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006401,biological_process RNA catabolic process;GO:0016075,biological_process rRNA catabolic process;GO:0031125,biological_process rRNA 3'-end processing;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0035327,cellular_component transcriptionally active chromatin;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045006,biological_process DNA deamination;GO:0051607,biological_process defense response to virus;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071051,biological_process polyadenylation-dependent snoRNA 3'-end processing;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	RRP46, EXOSC5; exosome complex component RRP46; K12590	exosome component 5 [Source:HGNC Symbol%3BAcc:HGNC:24662]
ENSG00000148950	31.76	36.76	35.71	34.41	31.86	32.73	0.0800571264605318	4.11215952550936	0.40419402600745	0.764593179644997	11:31432400-31509645:-	IMMP1L	13;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0006627,biological_process protein processing involved in protein targeting to mitochondrion;GO:0008150,biological_process biological_process;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0033108,biological_process mitochondrial respiratory chain complex assembly;GO:0042720,cellular_component mitochondrial inner membrane peptidase complex	IMP1; mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-]; K09647	inner mitochondrial membrane peptidase subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:26317]
ENSG00000165055	24.68	25.00	24.60	24.82	23.62	23.36	0.0603398973871769	5.14303506026112	0.404277677310365	0.764634893867677	7:128476728-128506602:+	METTL2B	7;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016427,molecular_function tRNA (cytosine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	methyltransferase like 2B [Source:HGNC Symbol%3BAcc:HGNC:18272]
ENSG00000150773	4.92	5.66	5.90	5.58	7.61	5.31	-0.153819631595233	2.64345817815435	0.404505172597592	0.764779762580384	11:112064009-112074274:-	PIH1D2	2;GO:0005515,molecular_function protein binding;GO:0017160,molecular_function Ral GTPase binding	NA	PIH1 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25210]
ENSG00000160007	51.32	45.56	52.11	55.16	47.21	54.74	-0.0639483510104134	7.84433416083569	0.404564814566906	0.764779762580384	19:46918675-47005077:+	ARHGAP35	44;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001843,biological_process neural tube closure;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005525,molecular_function GTP binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0007413,biological_process axonal fasciculation;GO:0008064,biological_process regulation of actin polymerization or depolymerization;GO:0008360,biological_process regulation of cell shape;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0021955,biological_process central nervous system neuron axonogenesis;GO:0030879,biological_process mammary gland development;GO:0030900,biological_process forebrain development;GO:0030950,biological_process establishment or maintenance of actin cytoskeleton polarity;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0043116,biological_process negative regulation of vascular permeability;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044319,biological_process wound healing, spreading of cells;GO:0045724,biological_process positive regulation of cilium assembly;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0050770,biological_process regulation of axonogenesis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0097485,biological_process neuron projection guidance	ARHGAP35, GRLF1; glucocorticoid receptor DNA-binding factor 1; K05732	Rho GTPase activating protein 35 [Source:HGNC Symbol%3BAcc:HGNC:4591]
ENSG00000065883	20.71	20.91	20.31	21.76	21.57	21.40	-0.0526433156014329	6.59522147240885	0.404565356861629	0.764779762580384	7:39950036-40097134:+	CDK13	42;GO:0000166,molecular_function nucleotide binding;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0002945,cellular_component cyclin K-CDK13 complex;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0007275,biological_process multicellular organism development;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0008380,biological_process RNA splicing;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0019908,cellular_component nuclear cyclin-dependent protein kinase holoenzyme complex;GO:0030097,biological_process hemopoiesis;GO:0030332,molecular_function cyclin binding;GO:0043312,biological_process neutrophil degranulation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051301,biological_process cell division;GO:0070816,biological_process phosphorylation of RNA polymerase II C-terminal domain;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2000737,biological_process negative regulation of stem cell differentiation	NA	cyclin dependent kinase 13 [Source:HGNC Symbol%3BAcc:HGNC:1733]
ENSG00000198774	2.98	2.86	2.31	2.41	2.62	2.21	0.181139833992744	1.80124151164799	0.404642349378485	0.764779762580384	12:85800696-85836570:-	RASSF9	9;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006605,biological_process protein targeting;GO:0007165,biological_process signal transduction;GO:0012510,cellular_component trans-Golgi network transport vesicle membrane;GO:0016197,biological_process endosomal transport;GO:0070062,cellular_component extracellular exosome	NA	Ras association domain family member 9 [Source:HGNC Symbol%3BAcc:HGNC:15739]
ENSG00000182518	22.05	23.99	20.96	24.17	25.60	22.55	-0.103555365645828	3.47814332810933	0.40470799682794	0.764779762580384	X:55143101-55161310:-	FAM104B	NA	NA	family with sequence similarity 104 member B [Source:HGNC Symbol%3BAcc:HGNC:25085]
ENSG00000165264	147.14	164.25	135.32	168.66	157.02	146.31	-0.0710381545588062	5.88043045754236	0.404723939449814	0.764779762580384	9:32552998-32573184:-	NDUFB6	13;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0042775,biological_process mitochondrial ATP synthesis coupled electron transport;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6; K03962	NADH:ubiquinone oxidoreductase subunit B6 [Source:HGNC Symbol%3BAcc:HGNC:7701]
ENSG00000067798	0.94	0.87	0.87	1.08	0.97	0.90	-0.118912403498482	2.82095283736219	0.40502366573223	0.765135997489621	12:77324640-78213008:+	NAV3	4;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0016020,cellular_component membrane	NA	neuron navigator 3 [Source:HGNC Symbol%3BAcc:HGNC:15998]
ENSG00000142864	266.87	287.87	258.08	292.45	275.92	282.02	-0.0540575353445817	8.40774229523277	0.405124923778233	0.765135997489621	1:67407809-67430415:-	SERBP1	13;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0042981,biological_process regulation of apoptotic process;GO:0043488,biological_process regulation of mRNA stability;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	SERPINE1 mRNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17860]
ENSG00000184517	7.64	6.10	5.47	6.83	8.03	6.42	-0.128419493876989	3.09282467913977	0.405222091881294	0.765135997489621	16:75148491-75172236:+	ZFP1	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP1 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:23328]
ENSG00000185261	0.33	0.47	0.17	0.35	0.42	0.44	-0.334894958902239	0.616783563182885	0.405306158553487	0.765135997489621	5:94152965-94618597:-	KIAA0825	NA	NA	KIAA0825 [Source:HGNC Symbol%3BAcc:HGNC:28532]
ENSG00000179119	12.10	10.79	11.50	10.71	10.44	11.81	0.0760627971578162	4.54009138350819	0.405337945898665	0.765135997489621	11:18606400-18634791:-	SPTY2D1	11;GO:0001042,molecular_function RNA polymerase I core binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006334,biological_process nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010847,biological_process regulation of chromatin assembly;GO:0042393,molecular_function histone binding;GO:0043486,biological_process histone exchange	NA	SPT2 chromatin protein domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26818]
ENSG00000129559	109.12	116.72	108.89	109.24	118.12	126.51	-0.073019504575815	4.8157057507952	0.405343456785259	0.765135997489621	14:24216851-24232454:-	NEDD8	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008104,biological_process protein localization;GO:0009653,biological_process anatomical structure morphogenesis;GO:0014070,biological_process response to organic cyclic compound;GO:0016311,biological_process dephosphorylation;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016791,molecular_function phosphatase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0070062,cellular_component extracellular exosome	NA	neural precursor cell expressed%2C developmentally down-regulated 8 [Source:HGNC Symbol%3BAcc:HGNC:7732]
ENSG00000160293	24.59	22.68	24.28	24.59	24.36	26.06	-0.054175921996875	6.01308680394027	0.405346008913268	0.765135997489621	9:133761893-133992604:-	VAV2	30;GO:0001525,biological_process angiogenesis;GO:0001784,molecular_function phosphotyrosine binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008361,biological_process regulation of cell size;GO:0010468,biological_process regulation of gene expression;GO:0016477,biological_process cell migration;GO:0030031,biological_process cell projection assembly;GO:0030032,biological_process lamellipodium assembly;GO:0030168,biological_process platelet activation;GO:0030193,biological_process regulation of blood coagulation;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	VAV; guanine nucleotide exchange factor VAV; K05730	vav guanine nucleotide exchange factor 2 [Source:HGNC Symbol%3BAcc:HGNC:12658]
ENSG00000165675	6.45	6.84	7.24	8.06	7.29	6.76	-0.0953699313078603	3.71855389821021	0.405410103526473	0.765135997489621	X:130623368-130903317:-	ENOX2	15;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007624,biological_process ultradian rhythm;GO:0009897,cellular_component external side of plasma membrane;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016491,molecular_function oxidoreductase activity;GO:0040008,biological_process regulation of growth;GO:0048511,biological_process rhythmic process;GO:0055114,biological_process oxidation-reduction process	NA	ecto-NOX disulfide-thiol exchanger 2 [Source:HGNC Symbol%3BAcc:HGNC:2259]
ENSG00000125812	6.72	6.27	6.69	6.18	7.96	7.09	-0.0931469771285889	3.88085585502297	0.405467219164322	0.765135997489621	20:23362181-23373063:+	GZF1	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001206,molecular_function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	GDNF inducible zinc finger protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15808]
ENSG00000048162	16.07	12.64	16.92	17.46	14.54	17.66	-0.100507025850005	3.84897162663286	0.405866500382592	0.765773045941499	5:176383937-176388975:-	NOP16	5;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	NOP16 nucleolar protein [Source:HGNC Symbol%3BAcc:HGNC:26934]
ENSG00000110172	18.86	19.98	17.15	19.61	18.71	20.96	-0.0766022275986206	4.73885225110935	0.406101561807413	0.765845657901989	11:90201159-90223364:-	CHORDC1	11;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0008270,molecular_function zinc ion binding;GO:0010824,biological_process regulation of centrosome duplication;GO:0043531,molecular_function ADP binding;GO:0046872,molecular_function metal ion binding;GO:0051879,molecular_function Hsp90 protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:1900034,biological_process regulation of cellular response to heat;GO:2000299,biological_process negative regulation of Rho-dependent protein serine/threonine kinase activity	NA	cysteine and histidine rich domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14525]
ENSG00000133101	1.92	1.64	2.48	2.15	1.52	1.61	0.222644336050957	1.48470812761978	0.406163706278162	0.765845657901989	13:36431519-36442882:+	CCNA1	12;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007141,biological_process male meiosis I;GO:0007283,biological_process spermatogenesis;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016579,biological_process protein deubiquitination;GO:0051301,biological_process cell division;GO:0097123,cellular_component cyclin A1-CDK2 complex	CCNA; cyclin-A; K06627	cyclin A1 [Source:HGNC Symbol%3BAcc:HGNC:1577]
ENSG00000088899	3.22	2.32	3.83	3.08	4.32	3.24	-0.155436363759491	2.79530621588132	0.406241103929752	0.765845657901989	20:3162616-3173592:-	LZTS3	8;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	leucine zipper tumor suppressor family member 3 [Source:HGNC Symbol%3BAcc:HGNC:30139]
ENSG00000169612	21.75	22.68	23.70	23.69	22.07	28.60	-0.118365125868003	3.10123130655777	0.406241791012768	0.765845657901989	15:82986206-82991057:+	FAM103A1	12;GO:0003723,molecular_function RNA binding;GO:0004482,molecular_function mRNA (guanine-N7-)-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005845,cellular_component mRNA cap binding complex;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006397,biological_process mRNA processing;GO:0031533,cellular_component mRNA cap methyltransferase complex;GO:0032259,biological_process methylation;GO:0036031,biological_process recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex;GO:0106005,biological_process RNA 5'-cap (guanine-N7)-methylation	NA	family with sequence similarity 103 member A1 [Source:HGNC Symbol%3BAcc:HGNC:31022]
ENSG00000101638	0.42	0.49	0.92	0.66	1.01	0.73	-0.354019583408433	0.156395570439641	0.40624817446394	0.765845657901989	18:46667820-46759257:-	ST8SIA5	13;GO:0000139,cellular_component Golgi membrane;GO:0003828,molecular_function alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006688,biological_process glycosphingolipid biosynthetic process;GO:0008373,molecular_function sialyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0097503,biological_process sialylation	SIAT8E; alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8E) [EC:2.4.99.-]; K03369	ST8 alpha-N-acetyl-neuraminide alpha-2%2C8-sialyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:17827]
ENSG00000124541	40.42	40.51	38.98	37.86	38.64	39.27	0.0610535523856503	4.97189511601523	0.406374954428947	0.765845657901989	6:43021644-43034156:+	RRP36	10;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000469,biological_process cleavage involved in rRNA processing;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030686,cellular_component 90S preribosome;GO:0042254,biological_process ribosome biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis	NA	ribosomal RNA processing 36 [Source:HGNC Symbol%3BAcc:HGNC:21374]
ENSG00000124181	27.11	29.22	28.70	28.51	27.10	26.92	0.0539227847359836	6.7781753539112	0.406377494686845	0.765845657901989	20:41136959-41196801:+	PLCG1	44;GO:0000186,biological_process activation of MAPKK activity;GO:0001701,biological_process in utero embryonic development;GO:0001726,cellular_component ruffle;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005168,molecular_function neurotrophin TRKA receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008180,cellular_component COP9 signalosome;GO:0009395,biological_process phospholipid catabolic process;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0016032,biological_process viral process;GO:0016042,biological_process lipid catabolic process;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0019722,biological_process calcium-mediated signaling;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0035254,molecular_function glutamate receptor binding;GO:0035556,biological_process intracellular signal transduction;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0043647,biological_process inositol phosphate metabolic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0071364,biological_process cellular response to epidermal growth factor stimulus	PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]; K01116	phospholipase C gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:9065]
ENSG00000169914	3.84	4.56	4.44	3.20	4.00	4.42	0.146245006567854	2.32371676168129	0.406398561878708	0.765845657901989	1:19882512-19912945:+	OTUD3	15;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0044313,biological_process protein K6-linked deubiquitination;GO:0050821,biological_process protein stabilization;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0071108,biological_process protein K48-linked deubiquitination;GO:1990167,biological_process protein K27-linked deubiquitination	NA	OTU deubiquitinase 3 [Source:HGNC Symbol%3BAcc:HGNC:29038]
ENSG00000176597	19.18	17.36	17.65	16.77	15.98	18.97	0.0804466251788882	4.33689774212018	0.406473412973024	0.765848116921669	3:183253243-183298504:+	B3GNT5	17;GO:0000139,cellular_component Golgi membrane;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0008378,molecular_function galactosyltransferase activity;GO:0008457,molecular_function beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity;GO:0008499,molecular_function UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0009247,biological_process glycolipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0047256,molecular_function lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	B3GNT5; beta-1,3-N-acetylglucosaminyltransferase 5 [EC:2.4.1.206]; K03766	UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:15684]
ENSG00000164749	3.54	3.87	5.68	5.83	4.94	4.11	-0.166875197595561	2.676968397319	0.406523261290331	0.765848116921669	8:75407913-75566843:+	HNF4G	18;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NR2A2, HNF4G; hepatocyte nuclear factor 4-gamma; K08037	hepatocyte nuclear factor 4 gamma [Source:HGNC Symbol%3BAcc:HGNC:5026]
ENSG00000172006	4.30	3.68	5.30	4.10	3.64	4.52	0.136989123902431	2.96674538088218	0.406720678615762	0.766042669607962	19:2819873-2835773:+	ZNF554	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 554 [Source:HGNC Symbol%3BAcc:HGNC:26629]
ENSG00000198026	6.61	6.62	6.65	6.47	6.40	6.29	0.065614675546674	4.7204157826928	0.406842876104047	0.766042669607962	20:45948652-45972172:-	ZNF335	25;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0010468,biological_process regulation of gene expression;GO:0021895,biological_process cerebral cortex neuron differentiation;GO:0035097,cellular_component histone methyltransferase complex;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0046872,molecular_function metal ion binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0048854,biological_process brain morphogenesis;GO:0050671,biological_process positive regulation of lymphocyte proliferation;GO:0050767,biological_process regulation of neurogenesis;GO:0050769,biological_process positive regulation of neurogenesis;GO:0051569,biological_process regulation of histone H3-K4 methylation;GO:0080182,biological_process histone H3-K4 trimethylation	NA	zinc finger protein 335 [Source:HGNC Symbol%3BAcc:HGNC:15807]
ENSG00000272899	5.08	5.61	5.44	5.25	4.31	4.66	0.187558072951987	1.49223496816818	0.406903097097589	0.766042669607962	7:128866307-128872044:+	AC025594.2	NA	NA	NA
ENSG00000119682	12.77	15.20	14.38	13.23	14.41	12.96	0.0686577586983375	5.18007273733238	0.406908169334657	0.766042669607962	14:74653436-74713115:-	AREL1	11;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	apoptosis resistant E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:20363]
ENSG00000256771	6.04	6.32	6.59	7.30	6.99	6.25	-0.103655871137671	3.3232105046177	0.406935097349142	0.766042669607962	19:19865885-19894674:+	ZNF253	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 253 [Source:HGNC Symbol%3BAcc:HGNC:13497]
ENSG00000132313	35.37	36.39	39.01	39.17	40.46	37.99	-0.0735728158220701	4.48326140744536	0.407176162443434	0.766298625580172	2:86199354-86213794:+	MRPL35	11;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35; K02916	mitochondrial ribosomal protein L35 [Source:HGNC Symbol%3BAcc:HGNC:14489]
ENSG00000187189	8.30	8.69	9.13	7.60	7.94	8.95	0.102602832370003	3.40991582821084	0.407213013316672	0.766298625580172	6:116249960-116254140:-	TSPYL4	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006334,biological_process nucleosome assembly	NA	TSPY like 4 [Source:HGNC Symbol%3BAcc:HGNC:21559]
ENSG00000047932	12.89	11.51	11.58	11.45	11.60	11.26	0.0849322956743628	4.03662680917034	0.407295469365716	0.766298625580172	6:117560268-117602542:-	GOPC	26;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0010360,biological_process negative regulation of anion channel activity;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030425,cellular_component dendrite;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0042995,cellular_component cell projection;GO:0043004,biological_process cytoplasmic sequestering of CFTR protein;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0045176,biological_process apical protein localization;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0051260,biological_process protein homooligomerization;GO:2000009,biological_process negative regulation of protein localization to cell surface	NA	golgi associated PDZ and coiled-coil motif containing [Source:HGNC Symbol%3BAcc:HGNC:17643]
ENSG00000126368	10.58	9.60	12.11	13.13	10.38	11.34	-0.0925927220392693	4.38086376682152	0.407346841434566	0.766298625580172	17:40092786-40100725:-	NR1D1	51;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001222,molecular_function transcription corepressor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005978,biological_process glycogen biosynthetic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007623,biological_process circadian rhythm;GO:0008270,molecular_function zinc ion binding;GO:0010498,biological_process proteasomal protein catabolic process;GO:0010871,biological_process negative regulation of receptor biosynthetic process;GO:0016604,cellular_component nuclear body;GO:0019216,biological_process regulation of lipid metabolic process;GO:0020037,molecular_function heme binding;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032922,biological_process circadian regulation of gene expression;GO:0034144,biological_process negative regulation of toll-like receptor 4 signaling pathway;GO:0035947,biological_process regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter;GO:0042752,biological_process regulation of circadian rhythm;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044321,biological_process response to leptin;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0060086,biological_process circadian temperature homeostasis;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0061469,biological_process regulation of type B pancreatic cell proliferation;GO:0070859,biological_process positive regulation of bile acid biosynthetic process;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:2000188,biological_process regulation of cholesterol homeostasis	NR1D1; nuclear receptor subfamily 1 group D member 1; K03728	nuclear receptor subfamily 1 group D member 1 [Source:HGNC Symbol%3BAcc:HGNC:7962]
ENSG00000068024	3.54	3.07	3.90	3.00	3.11	3.73	0.113147109191962	3.58968699257611	0.407385515279753	0.766298625580172	2:239048167-239401654:-	HDAC4	78;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001025,molecular_function RNA polymerase III transcription factor binding;GO:0001047,molecular_function core promoter binding;GO:0001501,biological_process skeletal system development;GO:0002076,biological_process osteoblast development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006476,biological_process protein deacetylation;GO:0006954,biological_process inflammatory response;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0010882,biological_process regulation of cardiac muscle contraction by calcium ion signaling;GO:0014894,biological_process response to denervation involved in regulation of muscle adaptation;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019901,molecular_function protein kinase binding;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030183,biological_process B cell differentiation;GO:0030955,molecular_function potassium ion binding;GO:0031594,cellular_component neuromuscular junction;GO:0031672,cellular_component A band;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033235,biological_process positive regulation of protein sumoylation;GO:0033558,molecular_function protein deacetylase activity;GO:0033613,molecular_function activating transcription factor binding;GO:0034983,biological_process peptidyl-lysine deacetylation;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042113,biological_process B cell activation;GO:0042493,biological_process response to drug;GO:0042641,cellular_component actomyosin;GO:0042826,molecular_function histone deacetylase binding;GO:0043234,cellular_component protein complex;GO:0043393,biological_process regulation of protein binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045820,biological_process negative regulation of glycolytic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048742,biological_process regulation of skeletal muscle fiber development;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051153,biological_process regulation of striated muscle cell differentiation;GO:0070491,molecular_function repressing transcription factor binding;GO:0070555,biological_process response to interleukin-1;GO:0070932,biological_process histone H3 deacetylation;GO:0070933,biological_process histone H4 deacetylation;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071374,biological_process cellular response to parathyroid hormone stimulus;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903428,biological_process positive regulation of reactive oxygen species biosynthetic process	HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]; K11406	histone deacetylase 4 [Source:HGNC Symbol%3BAcc:HGNC:14063]
ENSG00000099817	121.68	126.16	121.61	129.44	133.11	123.92	-0.0538384775988948	6.7231495467228	0.407493467770346	0.766298625580172	19:1086578-1095380:-	POLR2E	32;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001054,molecular_function RNA polymerase I activity;GO:0001055,molecular_function RNA polymerase II activity;GO:0001056,molecular_function RNA polymerase III activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016032,biological_process viral process;GO:0016070,biological_process RNA metabolic process;GO:0032481,biological_process positive regulation of type I interferon production;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1; K03013	RNA polymerase II subunit E [Source:HGNC Symbol%3BAcc:HGNC:9192]
ENSG00000172336	40.36	45.96	43.28	48.85	44.06	44.87	-0.0822109521279645	4.23683578683336	0.40750320047166	0.766298625580172	7:100706052-100707495:+	POP7	16;GO:0000172,cellular_component ribonuclease MRP complex;GO:0001682,biological_process tRNA 5'-leader removal;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004526,molecular_function ribonuclease P activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005655,cellular_component nucleolar ribonuclease P complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0030681,cellular_component multimeric ribonuclease P complex;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	RPP20, POP7; ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]; K14527	POP7 homolog%2C ribonuclease P/MRP subunit [Source:HGNC Symbol%3BAcc:HGNC:19949]
ENSG00000104728	10.99	11.22	11.58	10.62	11.05	11.08	0.0560838090789463	5.5323844376972	0.407629737952399	0.76642046913104	8:1823975-1958641:+	ARHGEF10	13;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0019894,molecular_function kinesin binding;GO:0022011,biological_process myelination in peripheral nervous system;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051298,biological_process centrosome duplication;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0090307,biological_process mitotic spindle assembly;GO:0090630,biological_process activation of GTPase activity	NA	Rho guanine nucleotide exchange factor 10 [Source:HGNC Symbol%3BAcc:HGNC:14103]
ENSG00000187624	3.62	4.70	4.19	3.84	6.07	4.20	-0.168886759417876	2.68757147598496	0.407769486530055	0.766567111358105	17:410326-431062:+	C17orf97	1;GO:0016598,biological_process protein arginylation	NA	chromosome 17 open reading frame 97 [Source:HGNC Symbol%3BAcc:HGNC:33800]
ENSG00000115129	3.33	3.68	2.48	3.02	2.99	2.37	0.178808803112697	1.68743013682306	0.407957859011779	0.76680510356045	2:24077432-24085861:-	TP53I3	10;GO:0003960,molecular_function NADPH:quinone reductase activity;GO:0005829,cellular_component cytosol;GO:0006739,biological_process NADP metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0048038,molecular_function quinone binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070402,molecular_function NADPH binding	TP53I3; tumor protein p53-inducible protein 3 [EC:1.-.-.-]; K10133	tumor protein p53 inducible protein 3 [Source:HGNC Symbol%3BAcc:HGNC:19373]
ENSG00000066279	15.57	16.48	14.37	14.76	18.96	15.57	-0.0749555929223073	7.38016740785253	0.408119080691238	0.766991998277114	1:197084127-197146694:-	ASPM	31;GO:0000922,cellular_component spindle pole;GO:0001764,biological_process neuron migration;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007283,biological_process spermatogenesis;GO:0007420,biological_process brain development;GO:0008584,biological_process male gonad development;GO:0021873,biological_process forebrain neuroblast division;GO:0021987,biological_process cerebral cortex development;GO:0030496,cellular_component midbody;GO:0036449,cellular_component microtubule minus-end;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045769,biological_process negative regulation of asymmetric cell division;GO:0048477,biological_process oogenesis;GO:0048589,biological_process developmental growth;GO:0051301,biological_process cell division;GO:0051445,biological_process regulation of meiotic cell cycle;GO:0051653,biological_process spindle localization;GO:0051661,biological_process maintenance of centrosome location;GO:0072687,cellular_component meiotic spindle;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0090306,biological_process spindle assembly involved in meiosis;GO:0097150,biological_process neuronal stem cell population maintenance;GO:0097431,cellular_component mitotic spindle pole	NA	abnormal spindle microtubule assembly [Source:HGNC Symbol%3BAcc:HGNC:19048]
ENSG00000141480	12.50	13.72	14.34	12.74	13.22	12.74	0.0774939243901908	4.2827916923241	0.408319960920926	0.767030449099364	17:4710488-4721499:+	ARRB2	86;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002031,biological_process G-protein coupled receptor internalization;GO:0002032,biological_process desensitization of G-protein coupled receptor protein signaling pathway by arrestin;GO:0002092,biological_process positive regulation of receptor internalization;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0007420,biological_process brain development;GO:0007628,biological_process adult walking behavior;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0010628,biological_process positive regulation of gene expression;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030139,cellular_component endocytic vesicle;GO:0030168,biological_process platelet activation;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031623,biological_process receptor internalization;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031691,molecular_function alpha-1A adrenergic receptor binding;GO:0031692,molecular_function alpha-1B adrenergic receptor binding;GO:0031701,molecular_function angiotensin receptor binding;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0031748,molecular_function D1 dopamine receptor binding;GO:0031762,molecular_function follicle-stimulating hormone receptor binding;GO:0031826,molecular_function type 2A serotonin receptor binding;GO:0031859,molecular_function platelet activating factor receptor binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032226,biological_process positive regulation of synaptic transmission, dopaminergic;GO:0032403,molecular_function protein complex binding;GO:0032691,biological_process negative regulation of interleukin-1 beta production;GO:0032695,biological_process negative regulation of interleukin-12 production;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032947,molecular_function protein complex scaffold;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034122,biological_process negative regulation of toll-like receptor signaling pathway;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034392,biological_process negative regulation of smooth muscle cell apoptotic process;GO:0042699,biological_process follicle-stimulating hormone signaling pathway;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043197,cellular_component dendritic spine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043422,molecular_function protein kinase B binding;GO:0045211,cellular_component postsynaptic membrane;GO:0045953,biological_process negative regulation of natural killer cell mediated cytotoxicity;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060326,biological_process cell chemotaxis;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0061024,biological_process membrane organization;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071889,molecular_function 14-3-3 protein binding;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0099565,biological_process chemical synaptic transmission, postsynaptic;GO:2000573,biological_process positive regulation of DNA biosynthetic process;GO:2000727,biological_process positive regulation of cardiac muscle cell differentiation	ARRB; beta-arrestin; K04439	arrestin beta 2 [Source:HGNC Symbol%3BAcc:HGNC:712]
ENSG00000109063	0.33	0.28	0.64	0.31	0.34	0.41	0.269251801078101	1.2735477031631	0.408350650030731	0.767030449099364	17:10628525-10657309:-	MYH3	27;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0003009,biological_process skeletal muscle contraction;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005859,cellular_component muscle myosin complex;GO:0006470,biological_process protein dephosphorylation;GO:0007517,biological_process muscle organ development;GO:0016459,cellular_component myosin complex;GO:0017018,molecular_function myosin phosphatase activity;GO:0030016,cellular_component myofibril;GO:0030017,cellular_component sarcomere;GO:0030048,biological_process actin filament-based movement;GO:0030049,biological_process muscle filament sliding;GO:0030326,biological_process embryonic limb morphogenesis;GO:0032982,cellular_component myosin filament;GO:0042623,molecular_function ATPase activity, coupled;GO:0043292,cellular_component contractile fiber;GO:0045214,biological_process sarcomere organization;GO:0046034,biological_process ATP metabolic process;GO:0051015,molecular_function actin filament binding;GO:0060325,biological_process face morphogenesis;GO:0070062,cellular_component extracellular exosome	MYH; myosin heavy chain; K10352	myosin heavy chain 3 [Source:HGNC Symbol%3BAcc:HGNC:7573]
ENSG00000114107	35.97	31.48	33.64	32.54	33.89	31.57	0.0600962997391847	5.96312474229131	0.40836712773418	0.767030449099364	3:138494343-138594538:-	CEP70	10;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0042802,molecular_function identical protein binding;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 70 [Source:HGNC Symbol%3BAcc:HGNC:29972]
ENSG00000110042	2.36	2.62	3.17	2.70	3.14	3.22	-0.141036472108262	2.45821768934978	0.408386710553266	0.767030449099364	11:59171429-59208587:+	DTX4	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007219,biological_process Notch signaling pathway;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032479,biological_process regulation of type I interferon production;GO:0046872,molecular_function metal ion binding	DTX; deltex [EC:2.3.2.27]; K06058	deltex E3 ubiquitin ligase 4 [Source:HGNC Symbol%3BAcc:HGNC:29151]
ENSG00000204237	26.12	25.75	24.31	24.27	24.47	23.97	0.0779987967942657	4.04014099902594	0.40852358558972	0.767171447492465	17:81665035-81666635:-	OXLD1	1;GO:0005739,cellular_component mitochondrion	NA	oxidoreductase like domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:27901]
ENSG00000100364	33.43	33.46	35.32	33.09	31.99	34.16	0.0545763275359701	5.82955491468022	0.40884277154357	0.767495437992369	22:45190337-45240769:-	KIAA0930	NA	NA	KIAA0930 [Source:HGNC Symbol%3BAcc:HGNC:1314]
ENSG00000067182	213.41	216.54	220.04	209.83	208.72	215.76	0.0470068755500573	8.62540353096812	0.408915174599425	0.767495437992369	12:6328756-6342114:-	TNFRSF1A	43;GO:0000139,cellular_component Golgi membrane;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006693,biological_process prostaglandin metabolic process;GO:0006915,biological_process apoptotic process;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009986,cellular_component cell surface;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042742,biological_process defense response to bacterium;GO:0042981,biological_process regulation of apoptotic process;GO:0043120,molecular_function tumor necrosis factor binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043235,cellular_component receptor complex;GO:0045121,cellular_component membrane raft;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050729,biological_process positive regulation of inflammatory response;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071550,biological_process death-inducing signaling complex assembly;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:1903140,biological_process regulation of establishment of endothelial barrier;GO:2000304,biological_process positive regulation of ceramide biosynthetic process	TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A; K03158	TNF receptor superfamily member 1A [Source:HGNC Symbol%3BAcc:HGNC:11916]
ENSG00000133858	11.93	12.05	11.85	11.62	11.71	11.53	0.0510215915334357	6.15904279810673	0.408967900450267	0.767495437992369	12:71609471-71667725:-	ZFC3H1	5;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0006396,biological_process RNA processing;GO:0046872,molecular_function metal ion binding	NA	zinc finger C3H1-type containing [Source:HGNC Symbol%3BAcc:HGNC:28328]
ENSG00000170689	45.86	45.74	42.79	48.82	41.06	52.88	-0.0775104943247518	5.12245525775386	0.408980027110045	0.767495437992369	17:48621158-48626356:-	HOXB9	17;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0030879,biological_process mammary gland development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048706,biological_process embryonic skeletal system development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060326,biological_process cell chemotaxis;GO:0090575,cellular_component RNA polymerase II transcription factor complex	NA	homeobox B9 [Source:HGNC Symbol%3BAcc:HGNC:5120]
ENSG00000054598	1.53	0.92	1.29	1.31	1.23	1.86	-0.203851140818732	1.28774211430688	0.409030485347637	0.767495437992369	6:1609971-1613897:+	FOXC1	77;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001223,molecular_function transcription coactivator binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001541,biological_process ovarian follicle development;GO:0001568,biological_process blood vessel development;GO:0001654,biological_process eye development;GO:0001657,biological_process ureteric bud development;GO:0001701,biological_process in utero embryonic development;GO:0001756,biological_process somitogenesis;GO:0001822,biological_process kidney development;GO:0001945,biological_process lymph vessel development;GO:0001958,biological_process endochondral ossification;GO:0001974,biological_process blood vessel remodeling;GO:0003007,biological_process heart morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005720,cellular_component nuclear heterochromatin;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007219,biological_process Notch signaling pathway;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0008301,molecular_function DNA binding, bending;GO:0008354,biological_process germ cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0014031,biological_process mesenchymal cell development;GO:0014032,biological_process neural crest cell development;GO:0016477,biological_process cell migration;GO:0016525,biological_process negative regulation of angiogenesis;GO:0021549,biological_process cerebellum development;GO:0030199,biological_process collagen fibril organization;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0032808,biological_process lacrimal gland development;GO:0035050,biological_process embryonic heart tube development;GO:0036438,biological_process maintenance of lens transparency;GO:0038084,biological_process vascular endothelial growth factor signaling pathway;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043010,biological_process camera-type eye development;GO:0043388,biological_process positive regulation of DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046620,biological_process regulation of organ growth;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048341,biological_process paraxial mesoderm formation;GO:0048762,biological_process mesenchymal cell differentiation;GO:0048844,biological_process artery morphogenesis;GO:0050880,biological_process regulation of blood vessel size;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0072010,biological_process glomerular epithelium development;GO:1901491,biological_process negative regulation of lymphangiogenesis;GO:1901534,biological_process positive regulation of hematopoietic progenitor cell differentiation;GO:1902038,biological_process positive regulation of hematopoietic stem cell differentiation;GO:1902257,biological_process negative regulation of apoptotic process involved in outflow tract morphogenesis;GO:1904798,biological_process positive regulation of core promoter binding;GO:1990841,molecular_function promoter-specific chromatin binding;GO:1990869,biological_process cellular response to chemokine	NA	forkhead box C1 [Source:HGNC Symbol%3BAcc:HGNC:3800]
ENSG00000122566	756.94	879.49	714.88	777.92	918.70	795.01	-0.0719899473338692	9.74041047927428	0.409099118633258	0.767495437992369	7:26189926-26201529:-	HNRNPA2B1	37;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000781,cellular_component chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0016363,cellular_component nuclear matrix;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031053,biological_process primary miRNA processing;GO:0035198,molecular_function miRNA binding;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043047,molecular_function single-stranded telomeric DNA binding;GO:0044806,biological_process G-quadruplex DNA unwinding;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0050658,biological_process RNA transport;GO:0051028,biological_process mRNA transport;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097157,molecular_function pre-mRNA intronic binding;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1904358,biological_process positive regulation of telomere maintenance via telomere lengthening;GO:1905663,biological_process positive regulation of telomerase RNA reverse transcriptase activity;GO:1990247,molecular_function N6-methyladenosine-containing RNA binding;GO:1990428,biological_process miRNA transport	NA	heterogeneous nuclear ribonucleoprotein A2/B1 [Source:HGNC Symbol%3BAcc:HGNC:5033]
ENSG00000196465	51.16	47.63	46.00	53.87	47.89	51.27	-0.0670498413400387	4.96205205524532	0.409144704668033	0.767495437992369	12:56152255-56159647:+	MYL6B	12;GO:0003774,molecular_function motor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005859,cellular_component muscle myosin complex;GO:0006936,biological_process muscle contraction;GO:0007519,biological_process skeletal muscle tissue development;GO:0008307,molecular_function structural constituent of muscle;GO:0016459,cellular_component myosin complex;GO:0016461,cellular_component unconventional myosin complex;GO:0030049,biological_process muscle filament sliding;GO:0070062,cellular_component extracellular exosome	MYL6; myosin light chain 6; K12751	myosin light chain 6B [Source:HGNC Symbol%3BAcc:HGNC:29823]
ENSG00000159063	22.15	25.08	23.85	25.52	24.18	24.92	-0.0624090367878373	5.54229852081304	0.409225275280073	0.767495437992369	11:78100935-78139660:-	ALG8	16;GO:0000033,molecular_function alpha-1,3-mannosyltransferase activity;GO:0004583,molecular_function dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0006490,biological_process oligosaccharide-lipid intermediate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0042281,molecular_function dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity;GO:0097502,biological_process mannosylation	ALG8; alpha-1,3-glucosyltransferase [EC:2.4.1.265]; K03849	ALG8%2C alpha-1%2C3-glucosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:23161]
ENSG00000138030	1.44	2.51	1.07	1.09	1.55	1.44	0.267361092424213	0.743531380493522	0.409252582298517	0.767495437992369	2:27086746-27100772:+	KHK	19;GO:0000166,molecular_function nucleotide binding;GO:0004454,molecular_function ketohexokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006000,biological_process fructose metabolic process;GO:0009744,biological_process response to sucrose;GO:0009749,biological_process response to glucose;GO:0009750,biological_process response to fructose;GO:0010043,biological_process response to zinc ion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032868,biological_process response to insulin;GO:0046835,biological_process carbohydrate phosphorylation;GO:0061624,biological_process fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0070062,cellular_component extracellular exosome	KHK; ketohexokinase [EC:2.7.1.3]; K00846	ketohexokinase [Source:HGNC Symbol%3BAcc:HGNC:6315]
ENSG00000233822	2.97	2.10	4.86	4.19	2.73	5.34	-0.272016030041782	1.02632507318608	0.409378468005669	0.767615547334496	6:27837759-27865798:+	HIST1H2BN	10;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006334,biological_process nucleosome assembly;GO:0016567,biological_process protein ubiquitination;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome	H2B; histone H2B; K11252	histone cluster 1 H2B family member n [Source:HGNC Symbol%3BAcc:HGNC:4749]
ENSG00000147459	4.20	3.75	4.01	3.74	3.58	4.15	0.0774223904055906	4.52183516350653	0.409480203882947	0.767690344479537	8:25184722-25418082:+	DOCK5	13;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1904694,biological_process negative regulation of vascular smooth muscle contraction;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration	NA	dedicator of cytokinesis 5 [Source:HGNC Symbol%3BAcc:HGNC:23476]
ENSG00000132464	0.47	0.36	0.45	0.50	0.58	0.47	-0.233694345266146	0.836207315881046	0.409553632335812	0.767705990321273	4:70628743-70686816:+	ENAM	13;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030345,molecular_function structural constituent of tooth enamel;GO:0031214,biological_process biomineral tissue development;GO:0036305,biological_process ameloblast differentiation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070175,biological_process positive regulation of enamel mineralization;GO:0097186,biological_process amelogenesis	NA	enamelin [Source:HGNC Symbol%3BAcc:HGNC:3344]
ENSG00000148677	3.25	2.30	2.61	2.89	2.14	2.13	0.2173184554978	1.38322421403208	0.409684297755706	0.767705990321273	10:90912095-90921276:-	ANKRD1	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001650,cellular_component fibrillar center;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030016,cellular_component myofibril;GO:0031432,molecular_function titin binding;GO:0031674,cellular_component I band;GO:0035690,biological_process cellular response to drug;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0035994,biological_process response to muscle stretch;GO:0042826,molecular_function histone deacetylase binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045214,biological_process sarcomere organization;GO:0045445,biological_process myoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050714,biological_process positive regulation of protein secretion;GO:0055008,biological_process cardiac muscle tissue morphogenesis;GO:0061629,molecular_function RNA polymerase II sequence-specific DNA binding transcription factor binding;GO:0070412,molecular_function R-SMAD binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071456,biological_process cellular response to hypoxia;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:2000279,biological_process negative regulation of DNA biosynthetic process	NA	ankyrin repeat domain 1 [Source:HGNC Symbol%3BAcc:HGNC:15819]
ENSG00000159140	39.59	43.05	38.26	38.13	40.61	38.62	0.0540107109625732	8.29358904466994	0.409776456695902	0.767705990321273	21:33542617-33577481:+	SON	16;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000281,biological_process mitotic cytokinesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043484,biological_process regulation of RNA splicing;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0050733,molecular_function RS domain binding;GO:0051726,biological_process regulation of cell cycle	NA	SON DNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:11183]
ENSG00000221883	5.36	3.30	4.74	4.65	5.23	5.42	-0.155544901870906	2.12512836856537	0.409784998407985	0.767705990321273	3:48917787-48919385:-	ARIH2OS	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ariadne RBR E3 ubiquitin protein ligase 2 opposite strand [Source:HGNC Symbol%3BAcc:HGNC:34425]
ENSG00000123243	27.46	27.39	28.91	27.86	30.37	29.48	-0.054124833107047	6.42266934343891	0.409848634741258	0.767705990321273	10:7559269-7666998:-	ITIH5	3;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030212,biological_process hyaluronan metabolic process	NA	inter-alpha-trypsin inhibitor heavy chain family member 5 [Source:HGNC Symbol%3BAcc:HGNC:21449]
ENSG00000121413	14.32	12.66	15.16	14.61	14.27	15.93	-0.0714985499720864	4.7573544724016	0.409859630859508	0.767705990321273	19:58083837-58118427:-	ZSCAN18	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 18 [Source:HGNC Symbol%3BAcc:HGNC:21037]
ENSG00000166888	66.30	71.08	64.04	65.75	67.72	61.81	0.0554482193714439	7.42433393513609	0.41040304004794	0.768444137281896	12:57095407-57132139:-	STAT6	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002296,biological_process T-helper 1 cell lineage commitment;GO:0002829,biological_process negative regulation of type 2 immune response;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019903,molecular_function protein phosphatase binding;GO:0031965,cellular_component nuclear membrane;GO:0032481,biological_process positive regulation of type I interferon production;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0034097,biological_process response to cytokine;GO:0035771,biological_process interleukin-4-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045121,cellular_component membrane raft;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048295,biological_process positive regulation of isotype switching to IgE isotypes;GO:0060443,biological_process mammary gland morphogenesis;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:1902170,biological_process cellular response to reactive nitrogen species	STAT6; signal transducer and activator of transcription 6; K11225	signal transducer and activator of transcription 6 [Source:HGNC Symbol%3BAcc:HGNC:11368]
ENSG00000155508	60.14	56.86	60.18	61.63	64.17	59.95	-0.0537959318626365	5.79771401315349	0.410433897149443	0.768444137281896	5:154857552-154876793:+	CNOT8	30;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016787,molecular_function hydrolase activity;GO:0030014,cellular_component CCR4-NOT complex;GO:0030015,cellular_component CCR4-NOT core complex;GO:0031047,biological_process gene silencing by RNA;GO:0035195,biological_process gene silencing by miRNA;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046872,molecular_function metal ion binding;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	CCR4-NOT transcription complex subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:9207]
ENSG00000130382	22.45	21.20	19.22	21.34	20.44	18.58	0.0712245551737715	5.11239592734354	0.410439428839037	0.768444137281896	19:6210378-6279948:-	MLLT1	12;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008023,cellular_component transcription elongation factor complex	MLLT1_3, ENL, AF9; YEATS domain-containing protein 1/3; K15187	MLLT1%2C super elongation complex subunit [Source:HGNC Symbol%3BAcc:HGNC:7134]
ENSG00000138378	0.70	1.32	1.11	0.74	1.01	0.88	0.232319993009191	1.23046781993901	0.410589818041158	0.768609773992595	2:191029575-191151596:-	STAT4	15;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007259,biological_process JAK-STAT cascade;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	STAT4; signal transducer and activator of transcription 4; K11222	signal transducer and activator of transcription 4 [Source:HGNC Symbol%3BAcc:HGNC:11365]
ENSG00000135931	21.85	21.88	20.60	20.61	20.41	21.41	0.053429672747125	5.78838389498255	0.41095541914191	0.769178169150864	2:231198545-231374837:+	ARMC9	1;GO:0070062,cellular_component extracellular exosome	NA	armadillo repeat containing 9 [Source:HGNC Symbol%3BAcc:HGNC:20730]
ENSG00000183530	7.26	7.95	6.77	6.63	7.19	7.34	0.0619363075836894	5.597924536827	0.411031555044517	0.769204687587455	22:31676255-31750140:-	PRR14L	NA	NA	proline rich 14 like [Source:HGNC Symbol%3BAcc:HGNC:28738]
ENSG00000122359	82.00	86.80	79.39	78.75	82.52	79.80	0.0525237228213387	7.03134190093137	0.411151318206111	0.769312829799888	10:80150888-80205572:-	ANXA11	27;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006909,biological_process phagocytosis;GO:0007049,biological_process cell cycle;GO:0008429,molecular_function phosphatidylethanolamine binding;GO:0016020,cellular_component membrane;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030496,cellular_component midbody;GO:0032506,biological_process cytokinetic process;GO:0042470,cellular_component melanosome;GO:0042581,cellular_component specific granule;GO:0042582,cellular_component azurophil granule;GO:0044548,molecular_function S100 protein binding;GO:0045335,cellular_component phagocytic vesicle;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051301,biological_process cell division;GO:0051592,biological_process response to calcium ion;GO:0070062,cellular_component extracellular exosome	NA	annexin A11 [Source:HGNC Symbol%3BAcc:HGNC:535]
ENSG00000128609	147.73	144.31	146.54	139.53	146.26	140.79	0.0526584036623765	6.0144932360713	0.411287147275452	0.769450996101007	7:123536996-123558255:-	NDUFA5	13;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0022904,biological_process respiratory electron transport chain;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0045271,cellular_component respiratory chain complex I;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5; K03949	NADH:ubiquinone oxidoreductase subunit A5 [Source:HGNC Symbol%3BAcc:HGNC:7688]
ENSG00000130772	25.69	25.73	22.53	24.36	28.68	26.14	-0.0893863909924593	4.00708567951887	0.411398380896418	0.769486903778813	1:28329001-28335967:+	MED18	12;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070847,cellular_component core mediator complex	NA	mediator complex subunit 18 [Source:HGNC Symbol%3BAcc:HGNC:25944]
ENSG00000219626	3.86	3.02	4.02	3.01	3.85	2.90	0.1892791037183	1.91102937640874	0.411443659196944	0.769486903778813	2:24076525-24169640:+	FAM228B	NA	NA	family with sequence similarity 228 member B [Source:HGNC Symbol%3BAcc:HGNC:24736]
ENSG00000171428	0.60	1.72	1.39	1.77	1.80	1.00	-0.316743259408164	0.664464988659977	0.411492311873339	0.769486903778813	8:18170476-18223689:+	NAT1	8;GO:0004060,molecular_function arylamine N-acetyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0016407,molecular_function acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups	nat; arylamine N-acetyltransferase [EC:2.3.1.5]; K00622	N-acetyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:7645]
ENSG00000162441	26.95	24.35	25.67	27.34	27.01	27.56	-0.0731761247278166	4.16711488171709	0.411687241024904	0.769680833708508	1:9922112-9943407:-	LZIC	2;GO:0008013,molecular_function beta-catenin binding;GO:0010212,biological_process response to ionizing radiation	NA	leucine zipper and CTNNBIP1 domain containing [Source:HGNC Symbol%3BAcc:HGNC:17497]
ENSG00000162139	5.67	6.49	5.95	5.63	6.13	5.21	0.099654785804581	3.3861319918528	0.411728289886754	0.769680833708508	11:74988133-75018893:+	NEU3	19;GO:0004308,molecular_function exo-alpha-sialidase activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006689,biological_process ganglioside catabolic process;GO:0008152,biological_process metabolic process;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016997,molecular_function alpha-sialidase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0052794,molecular_function exo-alpha-(2->3)-sialidase activity;GO:0052795,molecular_function exo-alpha-(2->6)-sialidase activity;GO:0052796,molecular_function exo-alpha-(2->8)-sialidase activity	NEU2_3_4; sialidase-2/3/4 [EC:3.2.1.18]; K12357	neuraminidase 3 [Source:HGNC Symbol%3BAcc:HGNC:7760]
ENSG00000165819	34.54	35.32	34.60	36.96	34.65	37.62	-0.0541698633938571	5.95805543841838	0.411782036305341	0.769680833708508	14:21498132-21511375:-	METTL3	28;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001510,biological_process RNA methylation;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006382,biological_process adenosine to inosine editing;GO:0006397,biological_process mRNA processing;GO:0007623,biological_process circadian rhythm;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0016070,biological_process RNA metabolic process;GO:0016422,molecular_function mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019827,biological_process stem cell population maintenance;GO:0031053,biological_process primary miRNA processing;GO:0032259,biological_process methylation;GO:0036396,cellular_component MIS complex;GO:0046982,molecular_function protein heterodimerization activity;GO:0048511,biological_process rhythmic process;GO:0061157,biological_process mRNA destabilization;GO:0080009,biological_process mRNA methylation;GO:1903679,biological_process positive regulation of cap-independent translational initiation;GO:1904047,molecular_function S-adenosyl-L-methionine binding;GO:1990744,biological_process primary miRNA methylation	NA	methyltransferase like 3 [Source:HGNC Symbol%3BAcc:HGNC:17563]
ENSG00000137642	1.95	2.01	1.73	1.77	1.88	1.71	0.0916413796691454	3.68064816419714	0.411953605496834	0.769694996263977	11:121452202-121633693:+	SORL1	56;GO:0000042,biological_process protein targeting to Golgi;GO:0000139,cellular_component Golgi membrane;GO:0001540,molecular_function beta-amyloid binding;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005641,cellular_component nuclear envelope lumen;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005887,cellular_component integral component of plasma membrane;GO:0006605,biological_process protein targeting;GO:0006622,biological_process protein targeting to lysosome;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0010008,cellular_component endosome membrane;GO:0014910,biological_process regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030306,molecular_function ADP-ribosylation factor binding;GO:0031985,cellular_component Golgi cisterna;GO:0032091,biological_process negative regulation of protein binding;GO:0032460,biological_process negative regulation of protein oligomerization;GO:0034362,cellular_component low-density lipoprotein particle;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0044267,biological_process cellular protein metabolic process;GO:0045053,biological_process protein retention in Golgi apparatus;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0050768,biological_process negative regulation of neurogenesis;GO:0051604,biological_process protein maturation;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:0070863,biological_process positive regulation of protein exit from endoplasmic reticulum;GO:1901215,biological_process negative regulation of neuron death;GO:1902430,biological_process negative regulation of beta-amyloid formation;GO:1902771,biological_process positive regulation of choline O-acetyltransferase activity;GO:1902948,biological_process negative regulation of tau-protein kinase activity;GO:1902953,biological_process positive regulation of ER to Golgi vesicle-mediated transport;GO:1902955,biological_process positive regulation of early endosome to recycling endosome transport;GO:1902960,biological_process negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902963,biological_process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:1902966,biological_process positive regulation of protein localization to early endosome;GO:1902997,biological_process negative regulation of neurofibrillary tangle assembly;GO:2001137,biological_process positive regulation of endocytic recycling	NA	sortilin related receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:11185]
ENSG00000100532	14.55	12.95	15.17	16.59	15.35	13.91	-0.0837205949208339	4.02766145723733	0.412005094852131	0.769694996263977	14:54509811-54539309:+	CGRRF1	10;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006950,biological_process response to stress;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	NA	cell growth regulator with ring finger domain 1 [Source:HGNC Symbol%3BAcc:HGNC:15528]
ENSG00000144455	37.81	39.78	37.81	33.76	41.70	35.51	0.067312409446513	5.7122587789104	0.412033253293809	0.769694996263977	3:3700813-4467281:-	SUMF1	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	SUMF1, FGE; formylglycine-generating enzyme [EC:1.8.3.7]; K13444	sulfatase modifying factor 1 [Source:HGNC Symbol%3BAcc:HGNC:20376]
ENSG00000144566	83.81	82.98	81.80	82.24	78.81	80.60	0.0525085116298422	5.82368568267394	0.412037642002266	0.769694996263977	3:19947078-19985175:+	RAB5A	52;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006909,biological_process phagocytosis;GO:0007596,biological_process blood coagulation;GO:0008021,cellular_component synaptic vesicle;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0019003,molecular_function GDP binding;GO:0030100,biological_process regulation of endocytosis;GO:0030139,cellular_component endocytic vesicle;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0036465,biological_process synaptic vesicle recycling;GO:0036477,cellular_component somatodendritic compartment;GO:0039694,biological_process viral RNA genome replication;GO:0042470,cellular_component melanosome;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043195,cellular_component terminal bouton;GO:0043679,cellular_component axon terminus;GO:0043687,biological_process post-translational protein modification;GO:0045022,biological_process early endosome to late endosome transport;GO:0045056,biological_process transcytosis;GO:0045121,cellular_component membrane raft;GO:0045335,cellular_component phagocytic vesicle;GO:0045921,biological_process positive regulation of exocytosis;GO:0051036,biological_process regulation of endosome size;GO:0051489,biological_process regulation of filopodium assembly;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0098559,cellular_component cytoplasmic side of early endosome membrane;GO:2000286,biological_process receptor internalization involved in canonical Wnt signaling pathway;GO:2000300,biological_process regulation of synaptic vesicle exocytosis;GO:2000785,biological_process regulation of autophagosome assembly	RAB5A; Ras-related protein Rab-5A; K07887	RAB5A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9783]
ENSG00000126003	5.74	4.75	5.49	5.28	4.13	5.43	0.125201939079523	2.96944708503584	0.412117312567162	0.769727986893797	20:32192502-32207791:-	PLAGL2	17;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0006915,biological_process apoptotic process;GO:0009791,biological_process post-embryonic development;GO:0034378,biological_process chylomicron assembly;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	NA	PLAG1 like zinc finger 2 [Source:HGNC Symbol%3BAcc:HGNC:9047]
ENSG00000131966	63.80	63.22	62.86	63.89	67.02	67.59	-0.0523655207310241	6.5236661817145	0.412311912817946	0.769975594073893	14:58200079-58235636:+	ACTR10	12;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005869,cellular_component dynactin complex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007018,biological_process microtubule-based movement;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	actin related protein 10 homolog [Source:HGNC Symbol%3BAcc:HGNC:17372]
ENSG00000076555	0.98	1.27	1.30	1.24	1.26	1.36	-0.119237924912248	3.23332627675402	0.41259384524428	0.770134373715211	12:109116594-109268226:+	ACACB	38;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003989,molecular_function acetyl-CoA carboxylase activity;GO:0004075,molecular_function biotin carboxylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006084,biological_process acetyl-CoA metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006768,biological_process biotin metabolic process;GO:0006853,biological_process carnitine shuttle;GO:0008152,biological_process metabolic process;GO:0009374,molecular_function biotin binding;GO:0010629,biological_process negative regulation of gene expression;GO:0010884,biological_process positive regulation of lipid storage;GO:0010906,biological_process regulation of glucose metabolic process;GO:0012505,cellular_component endomembrane system;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0031325,biological_process positive regulation of cellular metabolic process;GO:0031667,biological_process response to nutrient levels;GO:0031999,biological_process negative regulation of fatty acid beta-oxidation;GO:0042493,biological_process response to drug;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046322,biological_process negative regulation of fatty acid oxidation;GO:0046872,molecular_function metal ion binding;GO:0050995,biological_process negative regulation of lipid catabolic process;GO:0051289,biological_process protein homotetramerization;GO:0060421,biological_process positive regulation of heart growth;GO:0097009,biological_process energy homeostasis;GO:2001295,biological_process malonyl-CoA biosynthetic process	ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]; K11262	acetyl-CoA carboxylase beta [Source:HGNC Symbol%3BAcc:HGNC:85]
ENSG00000184831	20.33	27.51	17.59	18.40	20.81	20.95	0.119162053466071	3.64222290316485	0.412622142203763	0.770134373715211	X:23833352-23907934:-	APOO	20;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0034361,cellular_component very-low-density lipoprotein particle;GO:0034362,cellular_component low-density lipoprotein particle;GO:0034364,cellular_component high-density lipoprotein particle;GO:0042407,biological_process cristae formation;GO:0061617,cellular_component MICOS complex	NA	apolipoprotein O [Source:HGNC Symbol%3BAcc:HGNC:28727]
ENSG00000121931	12.28	13.01	14.96	12.04	12.82	13.66	0.0753354945694435	4.92889856183471	0.412669497478665	0.770134373715211	1:110947184-110964079:-	LRIF1	8;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005815,cellular_component microtubule organizing center;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016363,cellular_component nuclear matrix;GO:0042974,molecular_function retinoic acid receptor binding	NA	ligand dependent nuclear receptor interacting factor 1 [Source:HGNC Symbol%3BAcc:HGNC:30299]
ENSG00000172845	52.96	48.54	54.34	56.43	51.53	55.49	-0.0556055133879364	6.96569401830004	0.412683207200733	0.770134373715211	2:173906458-173965702:-	SP3	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001503,biological_process ossification;GO:0001701,biological_process in utero embryonic development;GO:0001779,biological_process natural killer cell differentiation;GO:0001829,biological_process trophectodermal cell differentiation;GO:0001889,biological_process liver development;GO:0001892,biological_process embryonic placenta development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016605,cellular_component PML body;GO:0016925,biological_process protein sumoylation;GO:0017053,cellular_component transcriptional repressor complex;GO:0030183,biological_process B cell differentiation;GO:0030217,biological_process T cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030219,biological_process megakaryocyte differentiation;GO:0030224,biological_process monocyte differentiation;GO:0030324,biological_process lung development;GO:0030851,biological_process granulocyte differentiation;GO:0043353,biological_process enucleate erythrocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0060136,biological_process embryonic process involved in female pregnancy;GO:0060216,biological_process definitive hemopoiesis	NA	Sp3 transcription factor [Source:HGNC Symbol%3BAcc:HGNC:11208]
ENSG00000122406	1101.24	1032.67	1034.55	1128.88	1042.39	1137.24	-0.0505600628920075	9.91073402022786	0.412768826142118	0.770134373715211	1:92832024-92841924:+	RPL5	37;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008097,molecular_function 5S rRNA binding;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043234,cellular_component protein complex;GO:0045727,biological_process positive regulation of translation;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904667,biological_process negative regulation of ubiquitin protein ligase activity;GO:1990948,molecular_function ubiquitin ligase inhibitor activity;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000435,biological_process negative regulation of protein neddylation	NA	ribosomal protein L5 [Source:HGNC Symbol%3BAcc:HGNC:10360]
ENSG00000184752	80.64	83.75	78.95	83.99	84.12	86.68	-0.0571532182946527	5.51826164658068	0.412769192647007	0.770134373715211	12:94897054-95003770:-	NDUFA12	14;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005829,cellular_component cytosol;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006979,biological_process response to oxidative stress;GO:0007585,biological_process respiratory gaseous exchange;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0042775,biological_process mitochondrial ATP synthesis coupled electron transport;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12; K11352	NADH:ubiquinone oxidoreductase subunit A12 [Source:HGNC Symbol%3BAcc:HGNC:23987]
ENSG00000143624	43.50	37.56	43.63	42.57	38.40	39.60	0.0618242593784329	7.11322122528105	0.412944646609478	0.770329834732885	1:153728066-153774808:+	INTS3	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0010212,biological_process response to ionizing radiation;GO:0016180,biological_process snRNA processing;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0070876,cellular_component SOSS complex	NA	integrator complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:26153]
ENSG00000115084	101.38	110.58	101.03	109.75	114.13	103.89	-0.0558411972447618	7.45588358854695	0.412998070583046	0.770329834732885	2:113705010-113756823:-	SLC35F5	3;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member F5 [Source:HGNC Symbol%3BAcc:HGNC:23617]
ENSG00000186104	18.89	15.13	19.05	16.59	15.04	18.81	0.0909514089060788	4.71067586631146	0.413142964371712	0.7703780143828	11:14877439-14892252:-	CYP2R1	20;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006766,biological_process vitamin metabolic process;GO:0008395,molecular_function steroid hydroxylase activity;GO:0010038,biological_process response to metal ion;GO:0010164,biological_process response to cesium ion;GO:0010212,biological_process response to ionizing radiation;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037,molecular_function heme binding;GO:0030343,molecular_function vitamin D3 25-hydroxylase activity;GO:0031090,cellular_component organelle membrane;GO:0036378,biological_process calcitriol biosynthetic process from calciol;GO:0042359,biological_process vitamin D metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	CYP2R1; vitamin D 25-hydroxylase [EC:1.14.14.24]; K07419	cytochrome P450 family 2 subfamily R member 1 [Source:HGNC Symbol%3BAcc:HGNC:20580]
ENSG00000170088	15.10	15.24	14.49	14.02	12.73	15.46	0.0944015349034252	3.60431648859499	0.413148025597865	0.7703780143828	4:165070607-165208549:-	TMEM192	10;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	transmembrane protein 192 [Source:HGNC Symbol%3BAcc:HGNC:26775]
ENSG00000243135	0.26	0.48	0.74	0.79	0.76	0.35	-0.344934100192797	0.072584212339802	0.413261768910838	0.770460229549644	2:233729107-233773299:+	UGT1A3	17;GO:0001972,molecular_function retinoic acid binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008152,biological_process metabolic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0042573,biological_process retinoic acid metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046982,molecular_function protein heterodimerization activity;GO:0052695,biological_process cellular glucuronidation;GO:0052696,biological_process flavonoid glucuronidation;GO:0052697,biological_process xenobiotic glucuronidation	UGT; glucuronosyltransferase [EC:2.4.1.17]; K00699	UDP glucuronosyltransferase family 1 member A3 [Source:HGNC Symbol%3BAcc:HGNC:12535]
ENSG00000137880	7.26	4.53	4.95	4.73	4.50	4.72	0.294668461761446	0.542223435107502	0.413316254617827	0.770460229549644	15:40764019-40767710:+	GCHFR	23;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006461,biological_process protein complex assembly;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0009890,biological_process negative regulation of biosynthetic process;GO:0016020,cellular_component membrane;GO:0016597,molecular_function amino acid binding;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0030425,cellular_component dendrite;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031965,cellular_component nuclear membrane;GO:0042133,biological_process neurotransmitter metabolic process;GO:0042470,cellular_component melanosome;GO:0043105,biological_process negative regulation of GTP cyclohydrolase I activity;GO:0043234,cellular_component protein complex;GO:0044549,molecular_function GTP cyclohydrolase binding;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051291,biological_process protein heterooligomerization	NA	GTP cyclohydrolase I feedback regulator [Source:HGNC Symbol%3BAcc:HGNC:4194]
ENSG00000136100	12.62	12.54	12.33	11.70	10.54	13.24	0.0884753515039756	3.83267213662596	0.413427140963553	0.770498670134361	13:52412601-52450628:-	VPS36	23;GO:0000814,cellular_component ESCRT II complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0008022,molecular_function protein C-terminus binding;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0031902,cellular_component late endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0036258,biological_process multivesicular body assembly;GO:0043130,molecular_function ubiquitin binding;GO:0043328,biological_process protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0070062,cellular_component extracellular exosome	VPS36, EAP45; ESCRT-II complex subunit VPS36; K12190	vacuolar protein sorting 36 homolog [Source:HGNC Symbol%3BAcc:HGNC:20312]
ENSG00000006025	6.60	5.27	7.11	5.93	5.47	6.52	0.103327660192692	4.00756900562584	0.413507474430371	0.770498670134361	17:47807371-47821834:-	OSBPL7	19;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006699,biological_process bile acid biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0010506,biological_process regulation of autophagy;GO:0015248,molecular_function sterol transporter activity;GO:0015485,molecular_function cholesterol binding;GO:0015918,biological_process sterol transport;GO:0016020,cellular_component membrane;GO:0071397,biological_process cellular response to cholesterol;GO:0097038,cellular_component perinuclear endoplasmic reticulum;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process	NA	oxysterol binding protein like 7 [Source:HGNC Symbol%3BAcc:HGNC:16387]
ENSG00000101343	13.33	13.67	14.84	14.80	13.80	15.51	-0.0646650472263274	5.19557694149162	0.413526125182133	0.770498670134361	20:20034367-20056046:-	CRNKL1	18;GO:0000245,biological_process spliceosomal complex assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0071010,cellular_component prespliceosome;GO:0071011,cellular_component precatalytic spliceosome;GO:0071012,cellular_component catalytic step 1 spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071014,cellular_component post-mRNA release spliceosomal complex	CRN, CRNKL1, CLF1, SYF3; crooked neck; K12869	crooked neck pre-mRNA splicing factor 1 [Source:HGNC Symbol%3BAcc:HGNC:15762]
ENSG00000173818	10.31	9.42	9.41	11.02	9.21	10.97	-0.0851235873186659	4.11630559038257	0.413606054409302	0.770498670134361	17:80415164-80438086:+	ENDOV	16;GO:0000287,molecular_function magnesium ion binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0016787,molecular_function hydrolase activity;GO:0016888,molecular_function endodeoxyribonuclease activity, producing 5'-phosphomonoesters;GO:0016891,molecular_function endoribonuclease activity, producing 5'-phosphomonoesters;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	endonuclease V [Source:HGNC Symbol%3BAcc:HGNC:26640]
ENSG00000133112	1586.21	1501.27	1569.68	1564.08	1467.28	1510.25	0.0480601117107483	9.99281182575518	0.413745344143756	0.770498670134361	13:45333470-45341370:-	TPT1	18;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005771,cellular_component multivesicular body;GO:0005829,cellular_component cytosol;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0008017,molecular_function microtubule binding;GO:0009615,biological_process response to virus;GO:0030154,biological_process cell differentiation;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045298,cellular_component tubulin complex;GO:0070062,cellular_component extracellular exosome;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	NA	tumor protein%2C translationally-controlled 1 [Source:HGNC Symbol%3BAcc:HGNC:12022]
ENSG00000157613	1.71	2.01	1.64	1.72	1.41	1.57	0.188443036394547	1.50556591230075	0.413765553231522	0.770498670134361	11:46277660-46321422:+	CREB3L1	25;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001649,biological_process osteoblast differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006986,biological_process response to unfolded protein;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0035497,molecular_function cAMP response element binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0070278,biological_process extracellular matrix constituent secretion;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	CREB3; cyclic AMP-responsive element-binding protein 3; K09048	cAMP responsive element binding protein 3 like 1 [Source:HGNC Symbol%3BAcc:HGNC:18856]
ENSG00000116044	129.86	123.01	123.86	128.59	132.02	132.15	-0.0479769055415523	7.98362257155998	0.413771379611347	0.770498670134361	2:177227594-177392697:-	NFE2L2	64;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001221,molecular_function transcription cofactor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007568,biological_process aging;GO:0008134,molecular_function transcription factor binding;GO:0010499,biological_process proteasomal ubiquitin-independent protein catabolic process;GO:0010628,biological_process positive regulation of gene expression;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016567,biological_process protein ubiquitination;GO:0019904,molecular_function protein domain specific binding;GO:0030194,biological_process positive regulation of blood coagulation;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032993,cellular_component protein-DNA complex;GO:0034599,biological_process cellular response to oxidative stress;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035690,biological_process cellular response to drug;GO:0036003,biological_process positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0036091,biological_process positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0042149,biological_process cellular response to glucose starvation;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045454,biological_process cell redox homeostasis;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045995,biological_process regulation of embryonic development;GO:0046223,biological_process aflatoxin catabolic process;GO:0046326,biological_process positive regulation of glucose import;GO:0060548,biological_process negative regulation of cell death;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071456,biological_process cellular response to hypoxia;GO:0071498,biological_process cellular response to fluid shear stress;GO:0071499,biological_process cellular response to laminar fluid shear stress;GO:1902037,biological_process negative regulation of hematopoietic stem cell differentiation;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1903071,biological_process positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death;GO:1903788,biological_process positive regulation of glutathione biosynthetic process;GO:1904753,biological_process negative regulation of vascular associated smooth muscle cell migration;GO:2000121,biological_process regulation of removal of superoxide radicals;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	NFE2L2, NRF2; nuclear factor erythroid 2-related factor 2; K05638	nuclear factor%2C erythroid 2 like 2 [Source:HGNC Symbol%3BAcc:HGNC:7782]
ENSG00000106993	20.02	20.08	24.46	22.32	23.87	22.75	-0.0791314195877383	4.52139553608758	0.413891322023174	0.770606416720213	9:4679558-4708398:+	CDC37L1	11;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0031072,molecular_function heat shock protein binding;GO:0031089,cellular_component platelet dense granule lumen;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding	NA	cell division cycle 37 like 1 [Source:HGNC Symbol%3BAcc:HGNC:17179]
ENSG00000104892	7.00	7.26	6.54	7.85	8.00	6.61	-0.101246145321033	3.50402128186815	0.41411057920568	0.770733959951827	19:45333433-45351520:+	KLC3	12;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0008088,biological_process axo-dendritic transport;GO:0019894,molecular_function kinesin binding;GO:0031514,cellular_component motile cilium;GO:0035253,cellular_component ciliary rootlet;GO:0043005,cellular_component neuron projection	KLC; kinesin light chain; K10407	kinesin light chain 3 [Source:HGNC Symbol%3BAcc:HGNC:20717]
ENSG00000111231	17.40	17.34	17.71	18.16	18.11	19.41	-0.0747299585405793	4.25180798961847	0.414172748998831	0.770733959951827	12:110452483-110469268:-	GPN3	9;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0016787,molecular_function hydrolase activity;GO:0043234,cellular_component protein complex;GO:0044376,biological_process RNA polymerase II complex import to nucleus;GO:1990022,biological_process RNA polymerase III complex localization to nucleus	NA	GPN-loop GTPase 3 [Source:HGNC Symbol%3BAcc:HGNC:30186]
ENSG00000122952	25.05	31.06	31.08	31.44	31.76	29.61	-0.0829878201424358	4.66766685002486	0.414305752917963	0.770733959951827	10:56357227-56361275:-	ZWINT	20;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0016604,cellular_component nuclear body;GO:0030425,cellular_component dendrite;GO:0043005,cellular_component neuron projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0047485,molecular_function protein N-terminus binding;GO:0051301,biological_process cell division;GO:0051649,biological_process establishment of localization in cell	NA	ZW10 interacting kinetochore protein [Source:HGNC Symbol%3BAcc:HGNC:13195]
ENSG00000198146	21.57	19.18	23.18	23.40	21.88	22.25	-0.0624926065245811	5.51349243737693	0.414370882420711	0.770733959951827	15:34978340-34988287:-	ZNF770	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 770 [Source:HGNC Symbol%3BAcc:HGNC:26061]
ENSG00000130725	86.64	87.14	96.55	88.90	82.89	90.03	0.0587293029785207	5.82078593280469	0.414381975934145	0.770733959951827	19:58555711-58558960:-	UBE2M	18;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0018169,molecular_function ribosomal S6-glutamic acid ligase activity;GO:0019788,molecular_function NEDD8 transferase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0070062,cellular_component extracellular exosome	UBE2M, UBC12; ubiquitin-conjugating enzyme E2 M; K10579	ubiquitin conjugating enzyme E2 M [Source:HGNC Symbol%3BAcc:HGNC:12491]
ENSG00000003056	100.87	112.11	104.69	103.23	106.73	97.88	0.0556463863666517	6.7776607800745	0.414406068657583	0.770733959951827	12:8940362-8949955:-	M6PR	27;GO:0000323,cellular_component lytic vacuole;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005537,molecular_function mannose binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0008333,biological_process endosome to lysosome transport;GO:0015578,molecular_function mannose transmembrane transporter activity;GO:0015761,biological_process mannose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030904,cellular_component retromer complex;GO:0032588,cellular_component trans-Golgi network membrane;GO:0033299,biological_process secretion of lysosomal enzymes;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061024,biological_process membrane organization;GO:1905394,molecular_function retromer complex binding	M6PR; cation-dependent mannose-6-phosphate receptor; K10089	mannose-6-phosphate receptor%2C cation dependent [Source:HGNC Symbol%3BAcc:HGNC:6752]
ENSG00000185340	10.61	11.03	10.19	9.63	10.17	10.66	0.0707399912513984	4.41698737626373	0.414423226469794	0.770733959951827	22:29306581-29312785:+	GAS2L1	8;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007050,biological_process cell cycle arrest;GO:0008017,molecular_function microtubule binding;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0009267,biological_process cellular response to starvation;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0097067,biological_process cellular response to thyroid hormone stimulus	NA	growth arrest specific 2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:16955]
ENSG00000183161	10.64	10.14	9.25	9.88	9.46	8.96	0.0975516368972151	3.46619914984461	0.414456552217711	0.770733959951827	11:22622518-22626787:-	FANCF	13;GO:0001541,biological_process ovarian follicle development;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0008150,biological_process biological_process;GO:0016567,biological_process protein ubiquitination;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0061630,molecular_function ubiquitin protein ligase activity	FANCF; fanconi anemia group F protein; K10893	Fanconi anemia complementation group F [Source:HGNC Symbol%3BAcc:HGNC:3587]
ENSG00000170312	106.33	106.02	92.93	105.92	114.26	101.01	-0.0623207641444995	6.57913352832995	0.414717229262278	0.770957767160498	10:60778330-60794852:+	CDK1	99;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000278,biological_process mitotic cell cycle;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001618,molecular_function virus receptor activity;GO:0003682,molecular_function chromatin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006461,biological_process protein complex assembly;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0007098,biological_process centrosome cycle;GO:0007344,biological_process pronuclear fusion;GO:0007569,biological_process cell aging;GO:0008283,biological_process cell proliferation;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0009636,biological_process response to toxic substance;GO:0010243,biological_process response to organonitrogen compound;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0014038,biological_process regulation of Schwann cell differentiation;GO:0014070,biological_process response to organic cyclic compound;GO:0014075,biological_process response to amine;GO:0014823,biological_process response to activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016572,biological_process histone phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030261,biological_process chromosome condensation;GO:0030332,molecular_function cyclin binding;GO:0030496,cellular_component midbody;GO:0030544,molecular_function Hsp70 protein binding;GO:0030855,biological_process epithelial cell differentiation;GO:0031100,biological_process organ regeneration;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0034501,biological_process protein localization to kinetochore;GO:0035173,molecular_function histone kinase activity;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044772,biological_process mitotic cell cycle phase transition;GO:0045471,biological_process response to ethanol;GO:0045740,biological_process positive regulation of DNA replication;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045995,biological_process regulation of embryonic development;GO:0046686,biological_process response to cadmium ion;GO:0046688,biological_process response to copper ion;GO:0046718,biological_process viral entry into host cell;GO:0048678,biological_process response to axon injury;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051445,biological_process regulation of meiotic cell cycle;GO:0055015,biological_process ventricular cardiac muscle cell development;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0072686,cellular_component mitotic spindle;GO:0090166,biological_process Golgi disassembly;GO:0097125,cellular_component cyclin B1-CDK1 complex;GO:0097472,molecular_function cyclin-dependent protein kinase activity;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1905448,biological_process positive regulation of mitochondrial ATP synthesis coupled electron transport	CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]; K02087	cyclin dependent kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:1722]
ENSG00000160446	17.32	22.69	16.34	16.48	19.11	17.10	0.0985355212411552	4.23789937716249	0.41472935870736	0.770957767160498	9:128720868-128724127:-	ZDHHC12	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 12 [Source:HGNC Symbol%3BAcc:HGNC:19159]
ENSG00000108064	36.68	32.97	34.61	36.87	34.24	39.15	-0.0662111307794352	4.9444677557185	0.414831360092827	0.770957767160498	10:58385021-58399221:+	TFAM	27;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001223,molecular_function transcription coactivator binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006356,biological_process regulation of transcription from RNA polymerase I promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0006391,biological_process transcription initiation from mitochondrial promoter;GO:0007005,biological_process mitochondrion organization;GO:0008301,molecular_function DNA binding, bending;GO:0031072,molecular_function heat shock protein binding;GO:0033108,biological_process mitochondrial respiratory chain complex assembly;GO:0042645,cellular_component mitochondrial nucleoid;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070363,molecular_function mitochondrial light strand promoter sense binding	TFAM, MTTFA; transcription factor A, mitochondrial; K11830	transcription factor A%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:11741]
ENSG00000136383	2.57	2.05	2.41	2.67	2.25	2.68	-0.0931246902962149	3.82554313486466	0.414878681642704	0.770957767160498	15:84816679-84873482:+	ALPK3	9;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	alpha kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:17574]
ENSG00000086544	7.58	6.76	8.37	7.86	5.63	7.76	0.112484272193421	3.92741457728332	0.414932182901387	0.770957767160498	19:40717102-40740860:+	ITPKC	12;GO:0000166,molecular_function nucleotide binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008440,molecular_function inositol-1,4,5-trisphosphate 3-kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0043647,biological_process inositol phosphate metabolic process	ITPK; 1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127]; K00911	inositol-trisphosphate 3-kinase C [Source:HGNC Symbol%3BAcc:HGNC:14897]
ENSG00000111215	7.06	8.84	8.61	8.62	6.87	6.50	0.160621110259221	2.08243449090715	0.415049639352679	0.770957767160498	12:10845848-11171613:-	PRR4	4;GO:0001895,biological_process retina homeostasis;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007601,biological_process visual perception	NA	proline rich 4 (lacrimal) [Source:HGNC Symbol%3BAcc:HGNC:18020]
ENSG00000135387	101.85	102.21	99.55	100.09	109.48	107.45	-0.0506588667456132	7.79478031064522	0.415093604495793	0.770957767160498	11:34051682-34101156:+	CAPRIN1	14;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis	NA	cell cycle associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6743]
ENSG00000145016	3.48	3.89	3.02	3.65	3.84	3.72	-0.106510123842529	3.50606401961838	0.415106711627128	0.770957767160498	3:197671392-197749727:-	RUBCN	17;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0006909,biological_process phagocytosis;GO:0006914,biological_process autophagy;GO:0010507,biological_process negative regulation of autophagy;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043553,biological_process negative regulation of phosphatidylinositol 3-kinase activity;GO:0045806,biological_process negative regulation of endocytosis;GO:0071985,biological_process multivesicular body sorting pathway;GO:1901097,biological_process negative regulation of autophagosome maturation	NA	RUN and cysteine rich domain containing beclin 1 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:28991]
ENSG00000162426	0.60	0.16	0.50	0.54	0.42	0.66	-0.286138534258518	0.395898230218363	0.415135883001754	0.770957767160498	1:8317825-8344167:+	SLC45A1	6;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015293,molecular_function symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 45 member 1 [Source:HGNC Symbol%3BAcc:HGNC:17939]
ENSG00000148154	224.43	221.05	220.93	228.67	232.28	232.91	-0.0463984668488051	8.06770140163887	0.415457621952471	0.771439859580558	9:111896765-111935369:+	UGCG	14;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006679,biological_process glucosylceramide biosynthetic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006688,biological_process glycosphingolipid biosynthetic process;GO:0008120,molecular_function ceramide glucosyltransferase activity;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	UGCG; ceramide glucosyltransferase [EC:2.4.1.80]; K00720	UDP-glucose ceramide glucosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:12524]
ENSG00000070413	25.63	27.42	27.11	24.91	25.65	27.00	0.056558568900617	5.45152188528044	0.41557297169845	0.771538632619332	22:19036281-19122454:-	DGCR2	6;GO:0007155,biological_process cell adhesion;GO:0009887,biological_process organ morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0050890,biological_process cognition	NA	DiGeorge syndrome critical region gene 2 [Source:HGNC Symbol%3BAcc:HGNC:2845]
ENSG00000105656	8.50	8.79	9.06	9.80	7.34	7.69	0.0976157034279048	4.03278629885622	0.415708823579716	0.771617440414463	19:18442662-18522127:-	ELL	20;GO:0001701,biological_process in utero embryonic development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008023,cellular_component transcription elongation factor complex;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0019902,molecular_function phosphatase binding;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0035327,cellular_component transcriptionally active chromatin;GO:0035363,cellular_component histone locus body;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042796,biological_process snRNA transcription from RNA polymerase III promoter;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter	NA	elongation factor for RNA polymerase II [Source:HGNC Symbol%3BAcc:HGNC:23114]
ENSG00000204946	9.71	6.59	9.30	8.19	8.33	7.60	0.108142478080249	4.34614327293039	0.415803736929546	0.771617440414463	7:149262170-149297302:+	ZNF783	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042802,molecular_function identical protein binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger family member 783 [Source:HGNC Symbol%3BAcc:HGNC:27222]
ENSG00000109794	10.61	10.83	10.29	9.07	10.64	10.68	0.0715988140817264	4.64942926992028	0.415830640930393	0.771617440414463	4:186104418-186172667:+	FAM149A	NA	NA	family with sequence similarity 149 member A [Source:HGNC Symbol%3BAcc:HGNC:24527]
ENSG00000170604	11.89	10.25	12.22	11.28	10.78	10.88	0.0814512052410303	4.31183283527174	0.415864068023263	0.771617440414463	19:45883606-45886170:-	IRF2BP1	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	interferon regulatory factor 2 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21728]
ENSG00000134291	92.78	110.72	91.06	99.05	110.78	101.00	-0.0688246191752803	6.44751169274325	0.416214563101676	0.772152349690794	12:47963568-47968878:+	TMEM106C	8;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 106C [Source:HGNC Symbol%3BAcc:HGNC:28775]
ENSG00000156469	23.38	20.76	22.40	21.55	20.34	22.23	0.0693063011128469	4.8058252567379	0.416390159294623	0.772339283435776	8:96239397-96261610:-	MTERF3	17;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008380,biological_process RNA splicing;GO:0016236,biological_process macroautophagy;GO:0019843,molecular_function rRNA binding;GO:0032502,biological_process developmental process;GO:0042254,biological_process ribosome biogenesis;GO:0042255,biological_process ribosome assembly;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	mitochondrial transcription termination factor 3 [Source:HGNC Symbol%3BAcc:HGNC:24258]
ENSG00000068383	9.32	8.45	9.71	9.61	9.46	10.50	-0.0882263767112149	3.73524688155452	0.416439766699077	0.772339283435776	10:132537819-132783480:+	INPP5A	14;GO:0004445,molecular_function inositol-polyphosphate 5-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0042731,molecular_function PH domain binding;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048016,biological_process inositol phosphate-mediated signaling;GO:0052658,molecular_function inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0070062,cellular_component extracellular exosome	E3.1.3.56; inositol-1,4,5-trisphosphate 5-phosphatase [EC:3.1.3.56]; K01106	inositol polyphosphate-5-phosphatase A [Source:HGNC Symbol%3BAcc:HGNC:6076]
ENSG00000139537	6.58	7.64	6.90	6.23	6.86	6.73	0.0936356904932762	3.38572658123393	0.416532307936805	0.772395509175315	12:48904109-48931840:+	CCDC65	NA	NA	coiled-coil domain containing 65 [Source:HGNC Symbol%3BAcc:HGNC:29937]
ENSG00000110422	13.60	15.10	15.91	14.01	15.11	13.95	0.0619649414036133	5.73911403761523	0.416598800010571	0.772403421139838	11:33256671-33357023:+	HIPK3	21;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0009299,biological_process mRNA transcription;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043508,biological_process negative regulation of JUN kinase activity	HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]; K08826	homeodomain interacting protein kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:4915]
ENSG00000136891	11.64	13.57	11.21	11.06	11.72	12.10	0.0673972245536257	5.05804477366041	0.416674709669831	0.772428788998149	9:100302076-100352939:-	TEX10	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0071339,cellular_component MLL1 complex;GO:0097344,cellular_component Rix1 complex	NA	testis expressed 10 [Source:HGNC Symbol%3BAcc:HGNC:25988]
ENSG00000175866	12.93	15.07	14.79	14.21	13.27	13.52	0.0688398480724201	4.78504443749486	0.416737638511055	0.772430089120163	17:81035121-81117432:+	BAIAP2	59;GO:0001221,molecular_function transcription cofactor binding;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007009,biological_process plasma membrane organization;GO:0007409,biological_process axonogenesis;GO:0007420,biological_process brain development;GO:0008022,molecular_function protein C-terminus binding;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008360,biological_process regulation of cell shape;GO:0009617,biological_process response to bacterium;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016358,biological_process dendrite development;GO:0030141,cellular_component secretory granule;GO:0030165,molecular_function PDZ domain binding;GO:0030175,cellular_component filopodium;GO:0030182,biological_process neuron differentiation;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035418,biological_process protein localization to synapse;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0044306,cellular_component neuron projection terminus;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048167,biological_process regulation of synaptic plasticity;GO:0051017,biological_process actin filament bundle assembly;GO:0051764,biological_process actin crosslink formation;GO:0060076,cellular_component excitatory synapse;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0061845,cellular_component neuron projection branch point;GO:0061846,cellular_component dendritic spine cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0070064,molecular_function proline-rich region binding;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0097060,cellular_component synaptic membrane;GO:0097110,molecular_function scaffold protein binding;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:0098793,cellular_component presynapse;GO:0098794,cellular_component postsynapse;GO:1905232,biological_process cellular response to L-glutamate;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential	BAIAP2, IRSP53; BAI1-associated protein 2; K05627	BAI1 associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:947]
ENSG00000116885	8.08	7.03	7.99	6.82	7.73	7.27	0.101872545133155	3.38629584671827	0.416821785070458	0.772458954253247	1:36415826-36450451:-	OSCP1	5;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0009925,cellular_component basal plasma membrane;GO:0016020,cellular_component membrane;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	organic solute carrier partner 1 [Source:HGNC Symbol%3BAcc:HGNC:29971]
ENSG00000160200	15.11	13.07	17.98	17.97	14.00	17.90	-0.0953554840181001	4.89540971447594	0.416877671356038	0.772458954253247	21:43053190-43076943:-	CBS	34;GO:0003824,molecular_function catalytic activity;GO:0004122,molecular_function cystathionine beta-synthase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006535,biological_process cysteine biosynthetic process from serine;GO:0006563,biological_process L-serine metabolic process;GO:0006565,biological_process L-serine catabolic process;GO:0008152,biological_process metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0019343,biological_process cysteine biosynthetic process via cystathionine;GO:0019344,biological_process cysteine biosynthetic process;GO:0019346,biological_process transsulfuration;GO:0019448,biological_process L-cysteine catabolic process;GO:0019825,molecular_function oxygen binding;GO:0019899,molecular_function enzyme binding;GO:0020037,molecular_function heme binding;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042262,biological_process DNA protection;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043418,biological_process homocysteine catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050421,molecular_function nitrite reductase (NO-forming) activity;GO:0050667,biological_process homocysteine metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070025,molecular_function carbon monoxide binding;GO:0070026,molecular_function nitric oxide binding;GO:0070814,biological_process hydrogen sulfide biosynthetic process;GO:0072341,molecular_function modified amino acid binding;GO:1904047,molecular_function S-adenosyl-L-methionine binding	CBS; cystathionine beta-synthase [EC:4.2.1.22]; K01697	cystathionine-beta-synthase [Source:HGNC Symbol%3BAcc:HGNC:1550]
ENSG00000115459	12.26	12.69	13.23	12.89	11.20	12.35	0.0774136417050589	4.20358403736895	0.417214865282813	0.77296837653068	2:85354393-85391752:+	ELMOD3	9;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0032420,cellular_component stereocilium;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0060091,cellular_component kinocilium	NA	ELMO domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:26158]
ENSG00000197933	7.64	8.09	7.60	7.00	7.71	7.42	0.0849245332920682	3.80718557911376	0.417413415258611	0.773220821311019	19:11721264-11739009:-	ZNF823	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 823 [Source:HGNC Symbol%3BAcc:HGNC:30936]
ENSG00000109180	186.23	194.32	191.81	206.72	196.04	194.90	-0.0511466389627604	7.19270501358538	0.417491394506023	0.773249877648949	4:48805211-48861817:+	OCIAD1	4;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0016020,cellular_component membrane	NA	OCIA domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16074]
ENSG00000162885	10.31	10.74	10.25	10.93	10.05	12.37	-0.0844600840853126	4.15484893282952	0.417558359470231	0.773258528435623	1:235449922-235504481:-	B3GALNT2	13;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0008376,molecular_function acetylgalactosaminyltransferase activity;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	B3GALNT2; beta-1,3-N-acetylgalactosaminyltransferase 2 [EC:2.4.1.313]; K09654	beta-1%2C3-N-acetylgalactosaminyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:28596]
ENSG00000183978	95.28	113.30	96.51	106.19	110.19	105.48	-0.0724961790946748	5.05886207331463	0.417690901557575	0.773292453114995	17:42795146-42798704:-	COA3	8;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly;GO:0070131,biological_process positive regulation of mitochondrial translation	NA	cytochrome c oxidase assembly factor 3 [Source:HGNC Symbol%3BAcc:HGNC:24990]
ENSG00000081087	24.53	23.65	24.02	22.64	25.96	20.21	0.0839602261053676	4.56672246596037	0.417701272708937	0.773292453114995	6:108041408-108165854:-	OSTM1	7;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030316,biological_process osteoclast differentiation;GO:0034220,biological_process ion transmembrane transport	NA	osteopetrosis associated transmembrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:21652]
ENSG00000159228	105.86	115.68	103.98	98.40	110.72	106.23	0.0563508163528676	7.1831678990916	0.417820758197528	0.7733983106928	21:36069940-36073166:+	CBR1	14;GO:0004090,molecular_function carbonyl reductase (NADPH) activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0016655,molecular_function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0017144,biological_process drug metabolic process;GO:0019371,biological_process cyclooxygenase pathway;GO:0030855,biological_process epithelial cell differentiation;GO:0042373,biological_process vitamin K metabolic process;GO:0047021,molecular_function 15-hydroxyprostaglandin dehydrogenase (NADP+) activity;GO:0050221,molecular_function prostaglandin-E2 9-reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]; K00079	carbonyl reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:1548]
ENSG00000047644	7.80	7.00	8.43	8.78	7.34	8.67	-0.0772657429411849	4.72555008584667	0.417921373640235	0.773469212911322	X:10015561-10144478:+	WWC3	6;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005829,cellular_component cytosol;GO:0019900,molecular_function kinase binding;GO:0032947,molecular_function protein complex scaffold;GO:0035331,biological_process negative regulation of hippo signaling;GO:0046621,biological_process negative regulation of organ growth	NA	WWC family member 3 [Source:HGNC Symbol%3BAcc:HGNC:29237]
ENSG00000156381	2.75	2.61	3.48	2.36	2.95	2.51	0.198427900995022	1.48504372196487	0.418499543716544	0.774423797876186	14:102501759-102509799:-	ANKRD9	2;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	ankyrin repeat domain 9 [Source:HGNC Symbol%3BAcc:HGNC:20096]
ENSG00000078140	102.76	112.61	105.86	118.80	112.37	105.71	-0.058931256713046	6.04358424925903	0.418644691113559	0.774546398953887	4:39698043-39782792:+	UBE2K	22;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010994,biological_process free ubiquitin chain polymerization;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032433,cellular_component filopodium tip;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0035458,biological_process cellular response to interferon-beta;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070062,cellular_component extracellular exosome;GO:0070936,biological_process protein K48-linked ubiquitination	HIP2, UBC1; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]; K04649	ubiquitin conjugating enzyme E2 K [Source:HGNC Symbol%3BAcc:HGNC:4914]
ENSG00000196083	6.38	4.26	6.77	5.53	4.23	6.24	0.140966998649433	3.82190412714995	0.418690593489131	0.774546398953887	3:190514050-190659750:+	IL1RAP	26;GO:0002114,molecular_function interleukin-33 receptor activity;GO:0002376,biological_process immune system process;GO:0004871,molecular_function signal transducer activity;GO:0004908,molecular_function interleukin-1 receptor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032736,biological_process positive regulation of interleukin-13 production;GO:0032754,biological_process positive regulation of interleukin-5 production;GO:0038172,biological_process interleukin-33-mediated signaling pathway;GO:0042094,biological_process interleukin-2 biosynthetic process;GO:0045087,biological_process innate immune response;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051965,biological_process positive regulation of synapse assembly;GO:0072602,biological_process interleukin-4 secretion;GO:1900006,biological_process positive regulation of dendrite development;GO:1990782,molecular_function protein tyrosine kinase binding;GO:2000778,biological_process positive regulation of interleukin-6 secretion	IL1RAP; interleukin 1 receptor accessory protein; K04723	interleukin 1 receptor accessory protein [Source:HGNC Symbol%3BAcc:HGNC:5995]
ENSG00000224051	16.06	18.16	17.66	15.86	16.66	16.32	0.0929489017343932	3.44701916802086	0.418836154750119	0.774681488809576	1:1324755-1328897:+	CPTP	20;GO:0005543,molecular_function phospholipid binding;GO:0005548,molecular_function phospholipid transporter activity;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0120009,biological_process intermembrane lipid transfer;GO:0120013,molecular_function intermembrane lipid transfer activity;GO:1902387,molecular_function ceramide 1-phosphate binding;GO:1902388,molecular_function ceramide 1-phosphate transporter activity;GO:1902389,biological_process ceramide 1-phosphate transport	NA	ceramide-1-phosphate transfer protein [Source:HGNC Symbol%3BAcc:HGNC:28116]
ENSG00000108733	6.43	6.21	7.45	7.30	8.24	6.53	-0.115787058433358	2.95179294706033	0.418930450082863	0.774681488809576	17:35574794-35578863:-	PEX12	16;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0006513,biological_process protein monoubiquitination;GO:0006625,biological_process protein targeting to peroxisome;GO:0007031,biological_process peroxisome organization;GO:0008022,molecular_function protein C-terminus binding;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016558,biological_process protein import into peroxisome matrix;GO:0016567,biological_process protein ubiquitination;GO:0046872,molecular_function metal ion binding;GO:1990429,cellular_component peroxisomal importomer complex	PEX12, PAF3; peroxin-12; K13345	peroxisomal biogenesis factor 12 [Source:HGNC Symbol%3BAcc:HGNC:8854]
ENSG00000185386	9.67	8.89	9.27	8.74	8.72	8.79	0.100093254622197	3.32812405328949	0.418950844628912	0.774681488809576	22:50263712-50270767:-	MAPK11	31;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0010628,biological_process positive regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0060043,biological_process regulation of cardiac muscle cell proliferation;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:0098586,biological_process cellular response to virus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2001184,biological_process positive regulation of interleukin-12 secretion	P38; p38 MAP kinase [EC:2.7.11.24]; K04441	mitogen-activated protein kinase 11 [Source:HGNC Symbol%3BAcc:HGNC:6873]
ENSG00000184979	4.11	4.54	3.30	3.15	3.87	3.72	0.152065209723773	2.12059107664079	0.41906222337611	0.774706429020995	22:18149898-18177397:+	USP18	15;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019785,molecular_function ISG15-specific protease activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0050727,biological_process regulation of inflammatory response;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway	NA	ubiquitin specific peptidase 18 [Source:HGNC Symbol%3BAcc:HGNC:12616]
ENSG00000129347	21.28	21.30	21.18	21.16	20.36	20.36	0.0547626529706773	5.48240498028624	0.419218484034145	0.774706429020995	19:10553077-10566037:-	KRI1	4;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005730,cellular_component nucleolus;GO:0030686,cellular_component 90S preribosome	NA	KRI1 homolog [Source:HGNC Symbol%3BAcc:HGNC:25769]
ENSG00000166025	8.39	7.79	8.11	8.10	8.00	7.26	0.0728464678035996	4.5868651720301	0.419329139478159	0.774706429020995	11:94706430-94876753:+	AMOTL1	13;GO:0003365,biological_process establishment of cell polarity involved in ameboidal cell migration;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005923,cellular_component bicellular tight junction;GO:0008180,cellular_component COP9 signalosome;GO:0016055,biological_process Wnt signaling pathway;GO:0016324,cellular_component apical plasma membrane;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035329,biological_process hippo signaling;GO:0042802,molecular_function identical protein binding;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration	AMOTL; angiomotin like; K06104	angiomotin like 1 [Source:HGNC Symbol%3BAcc:HGNC:17811]
ENSG00000140543	3.82	4.66	3.10	3.47	3.20	3.84	0.133464944553281	2.6565836678068	0.419354701582909	0.774706429020995	15:88494439-88546675:-	DET1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006461,biological_process protein complex assembly;GO:0016567,biological_process protein ubiquitination;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1990756,molecular_function protein binding, bridging involved in substrate recognition for ubiquitination	DET1; de-etiolated-1; K10571	de-etiolated homolog 1 (Arabidopsis) [Source:HGNC Symbol%3BAcc:HGNC:25477]
ENSG00000197150	10.37	11.83	9.46	9.41	10.95	9.73	0.0782128989080185	4.70189287729234	0.419385089417757	0.774706429020995	7:151028421-151047782:+	ABCB8	15;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043190,cellular_component ATP-binding cassette (ABC) transporter complex;GO:0055085,biological_process transmembrane transport	ABCB8; ATP-binding cassette, subfamily B (MDR/TAP), member 8; K05655	ATP binding cassette subfamily B member 8 [Source:HGNC Symbol%3BAcc:HGNC:49]
ENSG00000253846	0.56	0.85	1.03	0.77	0.52	0.79	0.22741721313092	1.22918533440758	0.419385291003391	0.774706429020995	5:141412986-141512979:+	PCDHGA10	9;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protocadherin gamma subfamily A%2C 10 [Source:HGNC Symbol%3BAcc:HGNC:8697]
ENSG00000119326	103.88	101.90	95.84	105.76	100.18	109.19	-0.0516356124012522	7.85341601029513	0.419556453656406	0.774706429020995	9:108942568-109013529:-	CTNNAL1	11;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007266,biological_process Rho protein signal transduction;GO:0016020,cellular_component membrane;GO:0045296,molecular_function cadherin binding;GO:0051015,molecular_function actin filament binding	NA	catenin alpha like 1 [Source:HGNC Symbol%3BAcc:HGNC:2512]
ENSG00000067334	30.08	27.72	26.40	28.52	29.32	30.44	-0.0559540096390097	6.04502254521707	0.419597987531969	0.774706429020995	1:93866282-93879918:-	DNTTIP2	5;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	deoxynucleotidyltransferase terminal interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:24013]
ENSG00000146826	5.60	6.60	7.00	5.29	6.51	6.15	0.104681648875676	3.52687523244552	0.419637187519469	0.774706429020995	7:100154419-100158715:-	C7orf43	3;GO:0005815,cellular_component microtubule organizing center;GO:0005886,cellular_component plasma membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	chromosome 7 open reading frame 43 [Source:HGNC Symbol%3BAcc:HGNC:25604]
ENSG00000133460	5.08	4.69	5.92	5.61	5.10	6.37	-0.106034432226499	3.45946030603615	0.419693929462164	0.774706429020995	22:23856702-23886309:+	SLC2A11	14;GO:0005215,molecular_function transporter activity;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0008645,biological_process hexose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0030054,cellular_component cell junction;GO:0034219,biological_process carbohydrate transmembrane transport;GO:0051119,molecular_function sugar transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 2 member 11 [Source:HGNC Symbol%3BAcc:HGNC:14239]
ENSG00000171004	1.03	0.67	0.93	0.60	0.84	0.81	0.255266565923938	0.836055754711665	0.419735216308265	0.774706429020995	X:132626015-132961395:-	HS6ST2	10;GO:0000139,cellular_component Golgi membrane;GO:0005654,cellular_component nucleoplasm;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0008146,molecular_function sulfotransferase activity;GO:0015015,biological_process heparan sulfate proteoglycan biosynthetic process, enzymatic modification;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0017095,molecular_function heparan sulfate 6-O-sulfotransferase activity;GO:0070062,cellular_component extracellular exosome	HS6ST2; heparan sulfate 6-O-sulfotransferase HS6ST2 [EC:2.8.2.-]; K08102	heparan sulfate 6-O-sulfotransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:19133]
ENSG00000064651	4.66	4.35	5.34	5.15	5.07	5.12	-0.077936379122768	4.19181469429821	0.4197545363364	0.774706429020995	5:128083765-128189688:+	SLC12A2	29;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006821,biological_process chloride transport;GO:0006972,biological_process hyperosmotic response;GO:0007214,biological_process gamma-aminobutyric acid signaling pathway;GO:0007568,biological_process aging;GO:0008511,molecular_function sodium:potassium:chloride symporter activity;GO:0008519,molecular_function ammonium transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015377,molecular_function cation:chloride symporter activity;GO:0015696,biological_process ammonium transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019901,molecular_function protein kinase binding;GO:0030321,biological_process transepithelial chloride transport;GO:0045795,biological_process positive regulation of cell volume;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0070634,biological_process transepithelial ammonium transport;GO:0072488,biological_process ammonium transmembrane transport;GO:1902476,biological_process chloride transmembrane transport;GO:1903561,cellular_component extracellular vesicle	SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; K10951	solute carrier family 12 member 2 [Source:HGNC Symbol%3BAcc:HGNC:10911]
ENSG00000187535	14.90	14.10	12.75	13.14	13.80	13.48	0.0580560010644602	5.93709294933424	0.419775674018788	0.774706429020995	16:1510426-1612110:-	IFT140	35;GO:0001750,cellular_component photoreceptor outer segment;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0021532,biological_process neural tube patterning;GO:0030030,biological_process cell projection organization;GO:0030991,cellular_component intraciliary transport particle A;GO:0031076,biological_process embryonic camera-type eye development;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035108,biological_process limb morphogenesis;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0035845,biological_process photoreceptor cell outer segment organization;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0060041,biological_process retina development in camera-type eye;GO:0060271,biological_process cilium morphogenesis;GO:0061512,biological_process protein localization to cilium;GO:0072001,biological_process renal system development;GO:0097542,cellular_component ciliary tip;GO:0097730,cellular_component non-motile cilium;GO:1902017,biological_process regulation of cilium assembly;GO:1905515,biological_process non-motile cilium assembly;GO:1990403,biological_process embryonic brain development	NA	intraflagellar transport 140 [Source:HGNC Symbol%3BAcc:HGNC:29077]
ENSG00000082438	32.34	34.05	34.12	32.70	38.29	34.48	-0.0580092353451752	7.07607936516356	0.420007034886011	0.774910445629488	2:164653623-164843679:-	COBLL1	6;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0030041,biological_process actin filament polymerization;GO:0045296,molecular_function cadherin binding;GO:0051639,biological_process actin filament network formation;GO:0070062,cellular_component extracellular exosome	NA	cordon-bleu WH2 repeat protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:23571]
ENSG00000118922	1.35	2.30	2.50	1.74	1.95	1.57	0.222656307287959	1.2760648837359	0.420121903099464	0.774910445629488	13:73686088-73995056:-	KLF12	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	Kruppel like factor 12 [Source:HGNC Symbol%3BAcc:HGNC:6346]
ENSG00000153767	10.30	12.48	9.28	12.85	10.65	11.05	-0.106927648994059	3.88007872745844	0.420127098455903	0.774910445629488	3:120742636-120783069:+	GTF2E1	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0016032,biological_process viral process;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:0097550,cellular_component transcriptional preinitiation complex	TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha; K03136	general transcription factor IIE subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4650]
ENSG00000136404	1.94	2.55	2.61	2.79	1.41	1.94	0.212268255731322	1.39161617491677	0.420135929999714	0.774910445629488	15:83107406-83144854:+	TM6SF1	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane 6 superfamily member 1 [Source:HGNC Symbol%3BAcc:HGNC:11860]
ENSG00000113971	4.62	3.97	4.12	3.91	4.08	4.16	0.0827987848148919	4.09992780911684	0.420352770757447	0.775195207756974	3:132680608-132722442:-	NPHP3	24;GO:0001822,biological_process kidney development;GO:0001947,biological_process heart looping;GO:0003283,biological_process atrial septum development;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0007368,biological_process determination of left/right symmetry;GO:0016055,biological_process Wnt signaling pathway;GO:0030324,biological_process lung development;GO:0035469,biological_process determination of pancreatic left/right asymmetry;GO:0042995,cellular_component cell projection;GO:0045494,biological_process photoreceptor cell maintenance;GO:0048496,biological_process maintenance of organ identity;GO:0060027,biological_process convergent extension involved in gastrulation;GO:0060271,biological_process cilium morphogenesis;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry;GO:0060993,biological_process kidney morphogenesis;GO:0071908,biological_process determination of intestine left/right asymmetry;GO:0071909,biological_process determination of stomach left/right asymmetry;GO:0071910,biological_process determination of liver left/right asymmetry;GO:0072189,biological_process ureter development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000095,biological_process regulation of Wnt signaling pathway, planar cell polarity pathway;GO:2000167,biological_process regulation of planar cell polarity pathway involved in neural tube closure	NA	nephrocystin 3 [Source:HGNC Symbol%3BAcc:HGNC:7907]
ENSG00000157600	7.85	9.76	8.67	9.92	8.77	9.87	-0.12051296987412	3.04921526160148	0.420550398604909	0.775315641184169	X:110002630-110182734:+	TMEM164	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 164 [Source:HGNC Symbol%3BAcc:HGNC:26217]
ENSG00000136319	7.65	7.67	7.75	7.88	7.87	9.11	-0.0982291718665864	3.42243248917448	0.42070078911219	0.775315641184169	14:20256557-20305994:-	TTC5	10;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	tetratricopeptide repeat domain 5 [Source:HGNC Symbol%3BAcc:HGNC:19274]
ENSG00000135452	30.79	29.13	30.30	29.76	29.17	27.75	0.0732078051661019	4.38294782722966	0.420735946352083	0.775315641184169	12:57738012-57750211:+	TSPAN31	5;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	tetraspanin 31 [Source:HGNC Symbol%3BAcc:HGNC:10539]
ENSG00000143437	20.79	22.50	23.11	21.57	21.25	21.55	0.0551036096739347	5.71032256105807	0.420787412833561	0.775315641184169	1:150809704-150876768:-	ARNT	38;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001666,biological_process response to hypoxia;GO:0001892,biological_process embryonic placenta development;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004874,molecular_function aryl hydrocarbon receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006805,biological_process xenobiotic metabolic process;GO:0008134,molecular_function transcription factor binding;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0016604,cellular_component nuclear body;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0030154,biological_process cell differentiation;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0035326,molecular_function enhancer binding;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043619,biological_process regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045821,biological_process positive regulation of glycolytic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046886,biological_process positive regulation of hormone biosynthetic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090575,cellular_component RNA polymerase II transcription factor complex	ARNT; aryl hydrocarbon receptor nuclear translocator; K09097	aryl hydrocarbon receptor nuclear translocator [Source:HGNC Symbol%3BAcc:HGNC:700]
ENSG00000160326	4.41	5.66	3.63	3.69	4.26	4.47	0.135283385332575	2.8218467812438	0.420845111324665	0.775315641184169	9:133471094-133479137:-	SLC2A6	17;GO:0005215,molecular_function transporter activity;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0008645,biological_process hexose transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0035428,biological_process hexose transmembrane transport;GO:0046323,biological_process glucose import;GO:0055056,molecular_function D-glucose transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 2 member 6 [Source:HGNC Symbol%3BAcc:HGNC:11011]
ENSG00000117528	37.80	37.25	32.63	34.39	37.07	32.47	0.0622960460039113	6.1440201517451	0.420877198347375	0.775315641184169	1:94418454-94518666:+	ABCD3	26;GO:0000166,molecular_function nucleotide binding;GO:0005324,molecular_function long-chain fatty acid transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0005829,cellular_component cytosol;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0007031,biological_process peroxisome organization;GO:0014070,biological_process response to organic cyclic compound;GO:0015910,biological_process peroxisomal long-chain fatty acid import;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042760,biological_process very long-chain fatty acid catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043621,molecular_function protein self-association;GO:0055085,biological_process transmembrane transport	ABCD3, PMP70; ATP-binding cassette, subfamily D (ALD), member 3; K05677	ATP binding cassette subfamily D member 3 [Source:HGNC Symbol%3BAcc:HGNC:67]
ENSG00000146729	91.40	94.50	92.56	90.29	93.46	86.93	0.0521469311985099	6.49855875582513	0.420878193977617	0.775315641184169	7:55951792-56000181:+	NIPSNAP2	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005887,cellular_component integral component of plasma membrane;GO:0006119,biological_process oxidative phosphorylation;GO:0006754,biological_process ATP biosynthetic process;GO:0016020,cellular_component membrane;GO:1901843,biological_process positive regulation of high voltage-gated calcium channel activity;GO:2000984,biological_process negative regulation of ATP citrate synthase activity	NA	nipsnap homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:4179]
ENSG00000106070	86.63	75.36	85.25	88.39	83.57	87.20	-0.0545345534902337	7.28596415602539	0.420954030633799	0.775315641184169	7:50590062-50793462:-	GRB10	16;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0009967,biological_process positive regulation of signal transduction;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0042326,biological_process negative regulation of phosphorylation;GO:0043234,cellular_component protein complex;GO:0046325,biological_process negative regulation of glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway	NA	growth factor receptor bound protein 10 [Source:HGNC Symbol%3BAcc:HGNC:4564]
ENSG00000163472	8.99	6.78	9.07	8.39	8.98	9.75	-0.10173586580857	3.45659217521206	0.421031794346882	0.775315641184169	1:156282934-156293185:+	TMEM79	16;GO:0002070,biological_process epithelial cell maturation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031069,biological_process hair follicle morphogenesis;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042335,biological_process cuticle development;GO:0042802,molecular_function identical protein binding;GO:0045055,biological_process regulated exocytosis;GO:0045684,biological_process positive regulation of epidermis development;GO:0061436,biological_process establishment of skin barrier;GO:0070268,biological_process cornification	NA	transmembrane protein 79 [Source:HGNC Symbol%3BAcc:HGNC:28196]
ENSG00000136807	28.36	26.90	29.60	29.65	29.47	29.96	-0.0552214655974233	5.41784816481554	0.421042676002778	0.775315641184169	9:127785678-127790787:+	CDK9	54;GO:0000166,molecular_function nucleotide binding;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001223,molecular_function transcription coactivator binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006282,biological_process regulation of DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008023,cellular_component transcription elongation factor complex;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0017069,molecular_function snRNA binding;GO:0019901,molecular_function protein kinase binding;GO:0030332,molecular_function cyclin binding;GO:0031056,biological_process regulation of histone modification;GO:0031297,biological_process replication fork processing;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0042493,biological_process response to drug;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050434,biological_process positive regulation of viral transcription;GO:0051147,biological_process regulation of muscle cell differentiation;GO:0070816,biological_process phosphorylation of RNA polymerase II C-terminal domain;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0097322,molecular_function 7SK snRNA binding;GO:1900364,biological_process negative regulation of mRNA polyadenylation;GO:1903839,biological_process positive regulation of mRNA 3'-UTR binding;GO:2001168,biological_process positive regulation of histone H2B ubiquitination	CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]; K02211	cyclin dependent kinase 9 [Source:HGNC Symbol%3BAcc:HGNC:1780]
ENSG00000132010	6.08	4.56	5.81	4.72	5.65	5.01	0.121781015033395	3.30433465861654	0.421140700082174	0.775316394272222	19:12092842-12140407:-	ZNF20	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 20 [Source:HGNC Symbol%3BAcc:HGNC:12992]
ENSG00000234719	5.00	4.03	6.11	5.25	4.44	4.26	0.144326816015326	2.8707030035293	0.421211354269291	0.775316394272222	16:11927372-11976643:-	NPIPB2	2;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex interacting protein family%2C member B2 [Source:HGNC Symbol%3BAcc:HGNC:37451]
ENSG00000180628	21.15	16.92	20.13	20.18	15.50	19.14	0.105234899639955	3.87572122591465	0.421231357149949	0.775316394272222	10:91163011-91284331:+	PCGF5	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031519,cellular_component PcG protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	PCGF5; polycomb group RING finger protein 5; K11489	polycomb group ring finger 5 [Source:HGNC Symbol%3BAcc:HGNC:28264]
ENSG00000105866	3.24	3.29	4.66	3.44	3.61	3.29	0.133634977469394	3.10629790924302	0.421381662020955	0.775316394272222	7:21428033-21514822:+	SP4	14;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	Sp4 transcription factor [Source:HGNC Symbol%3BAcc:HGNC:11209]
ENSG00000112303	4.08	4.13	5.23	5.75	4.19	4.96	-0.132525061336623	2.9297082953608	0.421406073951781	0.775316394272222	6:132743869-132763459:-	VNN2	12;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0006807,biological_process nitrogen compound metabolic process;GO:0006928,biological_process movement of cell or subcellular component;GO:0015939,biological_process pantothenate metabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016811,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0017159,molecular_function pantetheine hydrolase activity;GO:0031225,cellular_component anchored component of membrane	VNN; pantetheine hydrolase [EC:3.5.1.92]; K08069	vanin 2 [Source:HGNC Symbol%3BAcc:HGNC:12706]
ENSG00000128513	30.00	27.26	28.40	28.21	27.49	27.61	0.0546596380444885	5.88173296966274	0.42145114528501	0.775316394272222	7:124822385-124929983:-	POT1	33;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0007004,biological_process telomere maintenance via telomerase;GO:0010521,molecular_function telomerase inhibitor activity;GO:0016233,biological_process telomere capping;GO:0017151,molecular_function DEAD/H-box RNA helicase binding;GO:0032202,biological_process telomere assembly;GO:0032210,biological_process regulation of telomere maintenance via telomerase;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032508,biological_process DNA duplex unwinding;GO:0042162,molecular_function telomeric DNA binding;GO:0043047,molecular_function single-stranded telomeric DNA binding;GO:0051096,biological_process positive regulation of helicase activity;GO:0051973,biological_process positive regulation of telomerase activity;GO:0051974,biological_process negative regulation of telomerase activity;GO:0060383,biological_process positive regulation of DNA strand elongation;GO:0061820,biological_process telomeric D-loop disassembly;GO:0061821,molecular_function telomeric D-loop binding;GO:0070187,cellular_component telosome;GO:0070200,biological_process establishment of protein localization to telomere;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1905773,molecular_function 8-hydroxy-2'-deoxyguanosine DNA binding;GO:1905774,biological_process regulation of DNA helicase activity;GO:1905776,biological_process positive regulation of DNA helicase activity;GO:1990955,molecular_function G-rich single-stranded DNA binding	NA	protection of telomeres 1 [Source:HGNC Symbol%3BAcc:HGNC:17284]
ENSG00000162959	32.32	36.35	30.52	32.40	35.21	37.07	-0.0722644051912781	5.1607067784313	0.421525675978809	0.775316394272222	2:31865059-32011230:-	MEMO1	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032886,biological_process regulation of microtubule-based process;GO:2000145,biological_process regulation of cell motility	NA	mediator of cell motility 1 [Source:HGNC Symbol%3BAcc:HGNC:14014]
ENSG00000115806	66.39	68.05	65.46	65.20	66.95	62.17	0.0521193838367275	6.64270437884289	0.421542765241539	0.775316394272222	2:170928463-170967129:+	GORASP2	6;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006996,biological_process organelle organization;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane	NA	golgi reassembly stacking protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17500]
ENSG00000170043	134.27	168.28	138.40	134.08	159.88	125.76	0.0800969921680584	5.96422785369009	0.42175348122742	0.775386019332326	17:7930344-7932123:-	TRAPPC1	15;GO:0000139,cellular_component Golgi membrane;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 1 [Source:HGNC Symbol%3BAcc:HGNC:19894]
ENSG00000242265	34.37	50.36	36.10	34.46	45.97	32.03	0.113655392240402	6.51312159273434	0.421755653701361	0.775386019332326	7:94656324-94669695:+	PEG10	13;GO:0001890,biological_process placenta development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008270,molecular_function zinc ion binding;GO:0030154,biological_process cell differentiation;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0046872,molecular_function metal ion binding	NA	paternally expressed 10 [Source:HGNC Symbol%3BAcc:HGNC:14005]
ENSG00000112367	14.94	15.31	15.28	15.49	14.40	14.22	0.0572446480664065	5.37382652534274	0.421778696087327	0.775386019332326	6:109691311-109825428:+	FIG4	30;GO:0000139,cellular_component Golgi membrane;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007033,biological_process vacuole organization;GO:0007626,biological_process locomotory behavior;GO:0010008,cellular_component endosome membrane;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0031642,biological_process negative regulation of myelination;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0032288,biological_process myelin assembly;GO:0034593,molecular_function phosphatidylinositol bisphosphate phosphatase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0042578,molecular_function phosphoric ester hydrolase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043473,biological_process pigmentation;GO:0043812,molecular_function phosphatidylinositol-4-phosphate phosphatase activity;GO:0043813,molecular_function phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0048666,biological_process neuron development;GO:0055037,cellular_component recycling endosome	NA	FIG4 phosphoinositide 5-phosphatase [Source:HGNC Symbol%3BAcc:HGNC:16873]
ENSG00000182224	11.19	12.51	12.52	12.25	13.30	13.44	-0.0999812165397936	3.28240106815665	0.421830483247498	0.775386019332326	17:7857745-7862282:+	CYB5D1	1;GO:0046872,molecular_function metal ion binding	NA	cytochrome b5 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26516]
ENSG00000165533	18.91	17.02	17.17	17.31	18.32	20.56	-0.0678194435316264	5.06855050082587	0.4219531766306	0.775496710322126	14:88824152-88881078:+	TTC8	36;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001736,biological_process establishment of planar polarity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007411,biological_process axon guidance;GO:0007608,biological_process sensory perception of smell;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0021772,biological_process olfactory bulb development;GO:0030030,biological_process cell projection organization;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0032880,biological_process regulation of protein localization;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034464,cellular_component BBSome;GO:0035264,biological_process multicellular organism growth;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045444,biological_process fat cell differentiation;GO:0048560,biological_process establishment of anatomical structure orientation;GO:0050893,biological_process sensory processing;GO:0051492,biological_process regulation of stress fiber assembly;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0060170,cellular_component ciliary membrane;GO:0060219,biological_process camera-type eye photoreceptor cell differentiation;GO:0060271,biological_process cilium morphogenesis;GO:0061326,biological_process renal tubule development;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:1903251,biological_process multi-ciliated epithelial cell differentiation;GO:1905515,biological_process non-motile cilium assembly	NA	tetratricopeptide repeat domain 8 [Source:HGNC Symbol%3BAcc:HGNC:20087]
ENSG00000137496	5.19	5.95	6.25	6.46	4.08	4.97	0.172452002905766	2.00633601700283	0.422078871718862	0.775612884477607	11:71998540-72005715:+	IL18BP	10;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0032496,biological_process response to lipopolysaccharide;GO:0042007,molecular_function interleukin-18 binding;GO:0042088,biological_process T-helper 1 type immune response;GO:0048019,molecular_function receptor antagonist activity;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:1900116,biological_process extracellular negative regulation of signal transduction	NA	interleukin 18 binding protein [Source:HGNC Symbol%3BAcc:HGNC:5987]
ENSG00000079805	135.96	125.36	139.36	144.00	130.52	144.86	-0.0536369390807192	8.79485943919007	0.422539287341866	0.776344016248458	19:10718078-10833488:+	DNM2	90;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000266,biological_process mitochondrial fission;GO:0001891,cellular_component phagocytic cup;GO:0001917,cellular_component photoreceptor inner segment;GO:0002031,biological_process G-protein coupled receptor internalization;GO:0003281,biological_process ventricular septum development;GO:0003374,biological_process dynamin polymerization involved in mitochondrial fission;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005925,cellular_component focal adhesion;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006909,biological_process phagocytosis;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0008017,molecular_function microtubule binding;GO:0009416,biological_process response to light stimulus;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030516,biological_process regulation of axon extension;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031623,biological_process receptor internalization;GO:0031749,molecular_function D2 dopamine receptor binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032403,molecular_function protein complex binding;GO:0032587,cellular_component ruffle membrane;GO:0033572,biological_process transferrin transport;GO:0035020,biological_process regulation of Rac protein signal transduction;GO:0035904,biological_process aorta development;GO:0036312,molecular_function phosphatidylinositol 3-kinase regulatory subunit binding;GO:0042220,biological_process response to cocaine;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0044351,biological_process macropinocytosis;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045807,biological_process positive regulation of endocytosis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048489,biological_process synaptic vesicle transport;GO:0048812,biological_process neuron projection morphogenesis;GO:0050699,molecular_function WW domain binding;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0060976,biological_process coronary vasculature development;GO:0061024,biological_process membrane organization;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome;GO:0071245,biological_process cellular response to carbon monoxide;GO:0071481,biological_process cellular response to X-ray;GO:0071732,biological_process cellular response to nitric oxide;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1902856,biological_process negative regulation of nonmotile primary cilium assembly;GO:1903351,biological_process cellular response to dopamine;GO:1903358,biological_process regulation of Golgi organization;GO:1903408,biological_process positive regulation of sodium:potassium-exchanging ATPase activity;GO:1903526,biological_process negative regulation of membrane tubulation	DNM1_3; dynamin 1/3 [EC:3.6.5.5]; K01528	dynamin 2 [Source:HGNC Symbol%3BAcc:HGNC:2974]
ENSG00000154305	21.63	20.74	21.66	19.97	21.27	21.11	0.0507935720665239	6.95864863933011	0.422849960009838	0.776597355290818	1:222618085-222668012:+	MIA3	22;GO:0000139,cellular_component Golgi membrane;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007162,biological_process negative regulation of cell adhesion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030336,biological_process negative regulation of cell migration;GO:0042060,biological_process wound healing;GO:0042953,biological_process lipoprotein transport;GO:0042954,molecular_function lipoprotein transporter activity;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070971,cellular_component endoplasmic reticulum exit site;GO:0090110,biological_process cargo loading into COPII-coated vesicle	NA	MIA family member 3%2C ER export factor [Source:HGNC Symbol%3BAcc:HGNC:24008]
ENSG00000146670	8.16	10.23	7.92	10.38	8.95	8.98	-0.104783873754035	3.91353390783459	0.422928535960713	0.776597355290818	11:65066299-65084164:-	CDCA5	21;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006302,biological_process double-strand break repair;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0007076,biological_process mitotic chromosome condensation;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008278,cellular_component cohesin complex;GO:0031536,biological_process positive regulation of exit from mitosis;GO:0051301,biological_process cell division;GO:0071922,biological_process regulation of cohesin loading	CDCA5; sororin; K17390	cell division cycle associated 5 [Source:HGNC Symbol%3BAcc:HGNC:14626]
ENSG00000196437	4.14	3.50	4.11	4.32	4.62	3.89	-0.104062678619284	3.15734552938898	0.422931883315607	0.776597355290818	19:37411154-37469275:-	ZNF569	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 569 [Source:HGNC Symbol%3BAcc:HGNC:24737]
ENSG00000182287	58.10	63.08	59.70	58.89	53.30	62.00	0.0618586495047099	5.17717245232725	0.422959648208408	0.776597355290818	X:15825805-15854931:-	AP1S2	21;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030117,cellular_component membrane coat;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050690,biological_process regulation of defense response to virus by virus	AP1S1_2; AP-1 complex subunit sigma 1/2; K12394	adaptor related protein complex 1 sigma 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:560]
ENSG00000100209	25.86	20.86	23.74	27.10	22.11	26.64	-0.0876760295741767	4.13324221289141	0.423041433192609	0.776597355290818	22:28742030-28757515:+	HSCB	13;GO:0001671,molecular_function ATPase activator activity;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0032781,biological_process positive regulation of ATPase activity;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0051259,biological_process protein oligomerization;GO:0097428,biological_process protein maturation by iron-sulfur cluster transfer	NA	HscB mitochondrial iron-sulfur cluster cochaperone [Source:HGNC Symbol%3BAcc:HGNC:28913]
ENSG00000115295	39.91	36.84	41.59	39.45	36.78	38.69	0.0560686936391262	6.47590962776006	0.423052551073593	0.776597355290818	2:29097704-29189643:+	CLIP4	4;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	CAP-Gly domain containing linker protein family member 4 [Source:HGNC Symbol%3BAcc:HGNC:26108]
ENSG00000169203	1.31	1.34	1.03	1.05	1.64	1.50	-0.184784001346073	1.9639984258774	0.423199824274738	0.776752834351962	16:29483641-29505999:-	NPIPB12	3;GO:0005654,cellular_component nucleoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear pore complex interacting protein family%2C member B12 [Source:HGNC Symbol%3BAcc:HGNC:37491]
ENSG00000215910	10.64	10.01	10.28	10.90	10.49	11.01	-0.0533486005630031	5.55440101105197	0.423307404918826	0.776835425378088	1:11761786-11789585:+	C1orf167	NA	NA	chromosome 1 open reading frame 167 [Source:HGNC Symbol%3BAcc:HGNC:25262]
ENSG00000111732	1.29	0.96	2.21	1.50	2.02	2.23	-0.321952059889808	0.25094964172505	0.423791070459258	0.777453657647066	12:8602165-8612871:-	AICDA	21;GO:0000178,cellular_component exosome (RNase complex);GO:0003824,molecular_function catalytic activity;GO:0004126,molecular_function cytidine deaminase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0009972,biological_process cytidine deamination;GO:0016445,biological_process somatic diversification of immunoglobulins;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016787,molecular_function hydrolase activity;GO:0016814,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0030183,biological_process B cell differentiation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042742,biological_process defense response to bacterium;GO:0045190,biological_process isotype switching;GO:0046872,molecular_function metal ion binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0080111,biological_process DNA demethylation;GO:0090310,biological_process negative regulation of methylation-dependent chromatin silencing	AICDA, AID; activation-induced cytidine deaminase [EC:3.5.4.38]; K10989	activation induced cytidine deaminase [Source:HGNC Symbol%3BAcc:HGNC:13203]
ENSG00000168209	972.83	781.82	948.35	893.08	792.86	913.93	0.0681733056825097	9.26637135288936	0.423836116495563	0.777453657647066	10:72273919-72276036:+	DDIT4	24;GO:0001666,biological_process response to hypoxia;GO:0001764,biological_process neuron migration;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007420,biological_process brain development;GO:0008283,biological_process cell proliferation;GO:0009968,biological_process negative regulation of signal transduction;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0030182,biological_process neuron differentiation;GO:0032007,biological_process negative regulation of TOR signaling;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043241,biological_process protein complex disassembly;GO:0045820,biological_process negative regulation of glycolytic process;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0051607,biological_process defense response to virus;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0071889,molecular_function 14-3-3 protein binding;GO:0072593,biological_process reactive oxygen species metabolic process;GO:1901216,biological_process positive regulation of neuron death;GO:1902532,biological_process negative regulation of intracellular signal transduction	DDIT4, REDD1; DNA-damage-inducible transcript 4; K08270	DNA damage inducible transcript 4 [Source:HGNC Symbol%3BAcc:HGNC:24944]
ENSG00000144026	18.05	21.06	20.41	18.54	17.93	20.40	0.0712746474183584	4.60475723173947	0.423952142982774	0.777453657647066	2:95147329-95165413:-	ZNF514	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 514 [Source:HGNC Symbol%3BAcc:HGNC:25894]
ENSG00000147065	478.88	511.50	471.33	454.08	506.32	459.89	0.053112061378959	9.70074925742296	0.423964965756148	0.777453657647066	X:65588376-65741931:+	MSN	57;GO:0001771,biological_process immunological synapse formation;GO:0001931,cellular_component uropod;GO:0003725,molecular_function double-stranded RNA binding;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0007010,biological_process cytoskeleton organization;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008360,biological_process regulation of cell shape;GO:0008361,biological_process regulation of cell size;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0022612,biological_process gland morphogenesis;GO:0022614,biological_process membrane to membrane docking;GO:0030175,cellular_component filopodium;GO:0031143,cellular_component pseudopodium;GO:0031528,cellular_component microvillus membrane;GO:0031982,cellular_component vesicle;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042098,biological_process T cell proliferation;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0045177,cellular_component apical part of cell;GO:0045198,biological_process establishment of epithelial cell apical/basal polarity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0070489,biological_process T cell aggregation;GO:0071394,biological_process cellular response to testosterone stimulus;GO:0071437,cellular_component invadopodium;GO:0071803,biological_process positive regulation of podosome assembly;GO:0071944,cellular_component cell periphery;GO:0072562,cellular_component blood microparticle;GO:0072678,biological_process T cell migration;GO:1902115,biological_process regulation of organelle assembly;GO:1902966,biological_process positive regulation of protein localization to early endosome;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:2000401,biological_process regulation of lymphocyte migration;GO:2000643,biological_process positive regulation of early endosome to late endosome transport	MSN; moesin; K05763	moesin [Source:HGNC Symbol%3BAcc:HGNC:7373]
ENSG00000198807	0.97	1.12	1.08	0.37	1.41	0.69	0.371449424131378	0.140714622493797	0.423977319817414	0.777453657647066	14:36657567-36679715:+	PAX9	18;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007492,biological_process endoderm development;GO:0009887,biological_process organ morphogenesis;GO:0042476,biological_process odontogenesis;GO:0042481,biological_process regulation of odontogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060325,biological_process face morphogenesis;GO:0071363,biological_process cellular response to growth factor stimulus	NA	paired box 9 [Source:HGNC Symbol%3BAcc:HGNC:8623]
ENSG00000198695	2839.64	3034.66	2832.52	2671.01	3098.93	2662.25	0.0579195622897722	10.5434065227834	0.424020080743627	0.777453657647066	MT:14148-14673:-	MT-ND6	14;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035094,biological_process response to nicotine;GO:0042220,biological_process response to cocaine;GO:0042542,biological_process response to hydrogen peroxide;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]; K03884	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:7462]
ENSG00000105939	12.48	12.56	13.03	11.99	12.98	11.90	0.0591656223858205	5.26854524206344	0.424150045931031	0.777577096461659	7:139043519-139109719:-	ZC3HAV1	14;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009615,biological_process response to virus;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0061014,biological_process positive regulation of mRNA catabolic process	NA	zinc finger CCCH-type containing%2C antiviral 1 [Source:HGNC Symbol%3BAcc:HGNC:23721]
ENSG00000185129	8.92	8.11	8.38	7.91	7.54	8.37	0.108694012210187	3.01639111134789	0.424360448233706	0.777847939150176	5:140107776-140125619:+	PURA	29;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005662,cellular_component DNA replication factor A complex;GO:0005737,cellular_component cytoplasm;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0017148,biological_process negative regulation of translation;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0032422,molecular_function purine-rich negative regulatory element binding;GO:0042127,biological_process regulation of cell proliferation;GO:0043025,cellular_component neuronal cell body;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046332,molecular_function SMAD binding	NA	purine rich element binding protein A [Source:HGNC Symbol%3BAcc:HGNC:9701]
ENSG00000152133	6.77	8.16	5.85	6.31	7.54	4.93	0.149727979826028	2.52046198566711	0.424562904375163	0.778104138787672	2:37084450-37099244:+	GPATCH11	6;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome	NA	G-patch domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:26768]
ENSG00000178917	2.21	3.52	1.90	2.44	2.05	2.20	0.174477053286062	1.99061094217787	0.424730224618141	0.778222669220741	3:44498969-44510636:-	ZNF852	5;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 852 [Source:HGNC Symbol%3BAcc:HGNC:27713]
ENSG00000100601	8.35	8.27	8.64	9.75	9.03	8.50	-0.0962986944994032	3.37648425137975	0.424752967370541	0.778222669220741	14:77672403-77708020:-	ALKBH1	41;GO:0000049,molecular_function tRNA binding;GO:0001701,biological_process in utero embryonic development;GO:0001764,biological_process neuron migration;GO:0001890,biological_process placenta development;GO:0002101,biological_process tRNA wobble cytosine modification;GO:0003824,molecular_function catalytic activity;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0005634,cellular_component nucleus;GO:0005719,cellular_component nuclear euchromatin;GO:0005739,cellular_component mitochondrion;GO:0006281,biological_process DNA repair;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0006448,biological_process regulation of translational elongation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0008198,molecular_function ferrous iron binding;GO:0010468,biological_process regulation of gene expression;GO:0016491,molecular_function oxidoreductase activity;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0016829,molecular_function lyase activity;GO:0030154,biological_process cell differentiation;GO:0031175,biological_process neuron projection development;GO:0035552,biological_process oxidative single-stranded DNA demethylation;GO:0042056,molecular_function chemoattractant activity;GO:0042245,biological_process RNA repair;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043734,molecular_function DNA-N1-methyladenine dioxygenase activity;GO:0046872,molecular_function metal ion binding;GO:0048589,biological_process developmental growth;GO:0050918,biological_process positive chemotaxis;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070129,biological_process regulation of mitochondrial translation;GO:0070579,molecular_function methylcytosine dioxygenase activity;GO:0070989,biological_process oxidative demethylation;GO:0080111,biological_process DNA demethylation;GO:0103053,molecular_function 1-ethyladenine demethylase activity;GO:1990983,biological_process tRNA demethylation;GO:1990984,molecular_function tRNA demethylase activity	NA	alkB homolog 1%2C histone H2A dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:17911]
ENSG00000125885	9.41	9.55	9.01	9.22	10.65	9.71	-0.0700971749150535	4.68843853548186	0.424891817834778	0.778287635507256	20:5950651-5998977:+	MCM8	18;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007292,biological_process female gamete generation;GO:0016787,molecular_function hydrolase activity;GO:0048232,biological_process male gamete generation;GO:0097362,cellular_component MCM8-MCM9 complex	NA	minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol%3BAcc:HGNC:16147]
ENSG00000112941	25.24	23.81	23.73	23.89	24.93	21.69	0.0592024270892738	5.83096296983435	0.424913824686432	0.778287635507256	5:6713006-6757048:+	PAPD7	17;GO:0000166,molecular_function nucleotide binding;GO:0004652,molecular_function polynucleotide adenylyltransferase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006302,biological_process double-strand break repair;GO:0006397,biological_process mRNA processing;GO:0007062,biological_process sister chromatid cohesion;GO:0007076,biological_process mitotic chromosome condensation;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0031965,cellular_component nuclear membrane;GO:0042493,biological_process response to drug;GO:0043221,molecular_function SMC family protein binding;GO:0046872,molecular_function metal ion binding	PAPD5_7, TRF4; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]; K03514	poly(A) RNA polymerase D7%2C non-canonical [Source:HGNC Symbol%3BAcc:HGNC:16705]
ENSG00000108848	136.38	129.81	136.17	128.53	127.89	136.02	0.0482801726140899	7.93277404936776	0.424998454298396	0.778327797758335	17:50719543-50756213:+	LUC7L3	12;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005685,cellular_component U1 snRNP;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0071004,cellular_component U2-type prespliceosome	NA	LUC7 like 3 pre-mRNA splicing factor [Source:HGNC Symbol%3BAcc:HGNC:24309]
ENSG00000106789	1.70	2.97	1.64	1.76	1.78	1.92	0.186643366595524	1.67168962417723	0.425566018529816	0.779217444398055	9:98120974-98192640:-	CORO2A	6;GO:0003779,molecular_function actin binding;GO:0015629,cellular_component actin cytoskeleton;GO:0017053,cellular_component transcriptional repressor complex;GO:0030036,biological_process actin cytoskeleton organization;GO:0035556,biological_process intracellular signal transduction;GO:0051015,molecular_function actin filament binding	NA	coronin 2A [Source:HGNC Symbol%3BAcc:HGNC:2255]
ENSG00000164615	41.36	37.77	41.28	44.43	38.60	44.03	-0.0629815524705259	5.20390433547039	0.425609785951729	0.779217444398055	5:134738500-134752160:+	CAMLG	10;GO:0001881,biological_process receptor recycling;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0006952,biological_process defense response;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0050839,molecular_function cell adhesion molecule binding	NA	calcium modulating ligand [Source:HGNC Symbol%3BAcc:HGNC:1471]
ENSG00000163840	21.89	20.15	22.35	24.35	19.06	25.02	-0.0751055933502273	5.62645515234296	0.426051385172739	0.779910904608348	3:122564237-122575203:+	DTX3L	17;GO:0000209,biological_process protein polyubiquitination;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010390,biological_process histone monoubiquitination;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding	DTX; deltex [EC:2.3.2.27]; K06058	deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol%3BAcc:HGNC:30323]
ENSG00000085433	8.77	8.50	7.76	7.76	8.65	7.57	0.0737004110406687	4.51806795227473	0.426213735789201	0.779985746154077	1:108970213-109042113:-	WDR47	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007275,biological_process multicellular organism development	NA	WD repeat domain 47 [Source:HGNC Symbol%3BAcc:HGNC:29141]
ENSG00000183044	0.68	0.80	0.71	0.54	0.77	0.51	0.269450514712884	0.327185705034053	0.426309343440068	0.779985746154077	16:8674564-8784575:+	ABAT	42;GO:0001666,biological_process response to hypoxia;GO:0003824,molecular_function catalytic activity;GO:0003867,molecular_function 4-aminobutyrate transaminase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0007568,biological_process aging;GO:0007620,biological_process copulation;GO:0007626,biological_process locomotory behavior;GO:0008483,molecular_function transaminase activity;GO:0009448,biological_process gamma-aminobutyric acid metabolic process;GO:0009449,biological_process gamma-aminobutyric acid biosynthetic process;GO:0009450,biological_process gamma-aminobutyric acid catabolic process;GO:0010039,biological_process response to iron ion;GO:0014053,biological_process negative regulation of gamma-aminobutyric acid secretion;GO:0016740,molecular_function transferase activity;GO:0021549,biological_process cerebellum development;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0031652,biological_process positive regulation of heat generation;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032144,cellular_component 4-aminobutyrate transaminase complex;GO:0032145,molecular_function succinate-semialdehyde dehydrogenase binding;GO:0033602,biological_process negative regulation of dopamine secretion;GO:0035094,biological_process response to nicotine;GO:0035640,biological_process exploration behavior;GO:0042135,biological_process neurotransmitter catabolic process;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0045471,biological_process response to ethanol;GO:0045776,biological_process negative regulation of blood pressure;GO:0045964,biological_process positive regulation of dopamine metabolic process;GO:0046872,molecular_function metal ion binding;GO:0047298,molecular_function (S)-3-amino-2-methylpropionate transaminase activity;GO:0048148,biological_process behavioral response to cocaine;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0070062,cellular_component extracellular exosome;GO:0070474,biological_process positive regulation of uterine smooth muscle contraction;GO:0090331,biological_process negative regulation of platelet aggregation;GO:0097151,biological_process positive regulation of inhibitory postsynaptic potential;GO:1902722,biological_process positive regulation of prolactin secretion;GO:1904450,biological_process positive regulation of aspartate secretion	ABAT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22]; K13524	4-aminobutyrate aminotransferase [Source:HGNC Symbol%3BAcc:HGNC:23]
ENSG00000151006	5.70	6.57	7.59	5.73	5.71	7.04	0.11215167189138	3.42701287622026	0.426343975296281	0.779985746154077	16:31083424-31089628:-	PRSS53	7;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity	NA	protease%2C serine 53 [Source:HGNC Symbol%3BAcc:HGNC:34407]
ENSG00000106034	0.32	0.17	0.36	0.18	0.21	0.28	0.397194631082658	0.00031012641278328	0.426347425359042	0.779985746154077	7:120988676-121297444:+	CPED1	1;GO:0005783,cellular_component endoplasmic reticulum	NA	cadherin like and PC-esterase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26159]
ENSG00000117308	96.20	86.69	103.35	105.35	94.37	101.44	-0.0594954655137519	6.67970794816738	0.426414581007785	0.779985746154077	1:23795598-23800804:-	GALE	13;GO:0003824,molecular_function catalytic activity;GO:0003974,molecular_function UDP-N-acetylglucosamine 4-epimerase activity;GO:0003978,molecular_function UDP-glucose 4-epimerase activity;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006012,biological_process galactose metabolic process;GO:0016853,molecular_function isomerase activity;GO:0016857,molecular_function racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0019388,biological_process galactose catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0050662,molecular_function coenzyme binding;GO:0070062,cellular_component extracellular exosome	galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]; K01784	UDP-galactose-4-epimerase [Source:HGNC Symbol%3BAcc:HGNC:4116]
ENSG00000144283	37.29	34.90	34.92	36.58	39.72	35.80	-0.0530604023220471	7.08025483016003	0.426469286969123	0.779985746154077	2:158456963-158682879:+	PKP4	27;GO:0000922,cellular_component spindle pole;GO:0001533,cellular_component cornified envelope;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007043,biological_process cell-cell junction assembly;GO:0007155,biological_process cell adhesion;GO:0007267,biological_process cell-cell signaling;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0030155,biological_process regulation of cell adhesion;GO:0030496,cellular_component midbody;GO:0031424,biological_process keratinization;GO:0032467,biological_process positive regulation of cytokinesis;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044291,cellular_component cell-cell contact zone;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051233,cellular_component spindle midzone;GO:0070268,biological_process cornification;GO:0072686,cellular_component mitotic spindle	NA	plakophilin 4 [Source:HGNC Symbol%3BAcc:HGNC:9026]
ENSG00000167186	20.60	19.63	18.08	20.55	21.47	20.31	-0.0835522851315716	3.82366834579394	0.42667109392773	0.780059036094066	16:19067598-19080095:+	COQ7	12;GO:0004497,molecular_function monooxygenase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016709,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0031314,cellular_component extrinsic component of mitochondrial inner membrane;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	COQ7; 3-demethoxyubiquinol 3-hydroxylase [EC:1.14.99.60]; K06134	coenzyme Q7%2C hydroxylase [Source:HGNC Symbol%3BAcc:HGNC:2244]
ENSG00000168397	30.37	30.95	35.16	33.42	33.90	34.01	-0.0575884994493113	5.77819759844179	0.426850422940344	0.780059036094066	2:241637212-241673857:+	ATG4B	20;GO:0000045,biological_process autophagosome assembly;GO:0000422,biological_process mitophagy;GO:0004175,molecular_function endopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006501,biological_process C-terminal protein lipidation;GO:0006508,biological_process proteolysis;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0015031,biological_process protein transport;GO:0016236,biological_process macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0044804,biological_process nucleophagy;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0051697,biological_process protein delipidation	ATG4; cysteine protease ATG4 [EC:3.4.22.-]; K08342	autophagy related 4B cysteine peptidase [Source:HGNC Symbol%3BAcc:HGNC:20790]
ENSG00000103145	167.83	169.55	184.56	173.09	173.05	160.60	0.0554359119206378	6.3206192436788	0.426868930277604	0.780059036094066	16:3022619-3024286:-	HCFC1R1	3;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm	NA	host cell factor C1 regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:21198]
ENSG00000140374	63.84	66.92	58.32	61.74	62.64	58.79	0.0559441077330447	6.530754179512	0.426905033791338	0.780059036094066	15:76215354-76311472:-	ETFA	10;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0022904,biological_process respiratory electron transport chain;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	electron transfer flavoprotein alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:3481]
ENSG00000241685	32.64	28.39	27.31	28.72	26.99	29.29	0.0694590908361035	5.02611971027495	0.426919779844381	0.780059036094066	7:99325909-99366262:+	ARPC1A	15;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0015629,cellular_component actin cytoskeleton;GO:0030036,biological_process actin cytoskeleton organization;GO:0030833,biological_process regulation of actin filament polymerization;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0036195,cellular_component muscle cell projection membrane;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	NA	actin related protein 2/3 complex subunit 1A [Source:HGNC Symbol%3BAcc:HGNC:703]
ENSG00000135439	3.09	3.11	3.44	3.04	3.18	2.93	0.0913180746196924	3.57109427899982	0.426996626024243	0.780059036094066	12:57723760-57742157:-	AGAP2	27;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006810,biological_process transport;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030295,molecular_function protein kinase activator activity;GO:0032147,biological_process activation of protein kinase activity;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0046872,molecular_function metal ion binding;GO:0060749,biological_process mammary gland alveolus development;GO:0070062,cellular_component extracellular exosome;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11; K12491	ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 2 [Source:HGNC Symbol%3BAcc:HGNC:16921]
ENSG00000119318	154.10	151.96	159.38	165.58	154.47	165.50	-0.0489940172520782	7.66780525267242	0.427074155675262	0.780059036094066	9:107283136-107332194:+	RAD23B	23;GO:0000502,cellular_component proteasome complex;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006457,biological_process protein folding;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0016579,biological_process protein deubiquitination;GO:0031593,molecular_function polyubiquitin binding;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048568,biological_process embryonic organ development;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0071942,cellular_component XPC complex	RAD23, HR23; UV excision repair protein RAD23; K10839	RAD23 homolog B%2C nucleotide excision repair protein [Source:HGNC Symbol%3BAcc:HGNC:9813]
ENSG00000143515	7.87	8.03	8.26	7.53	8.03	7.78	0.0611471227405654	4.91721048028037	0.427214688792393	0.780059036094066	1:154325552-154351307:+	ATP8B2	18;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0007030,biological_process Golgi organization;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0034220,biological_process ion transmembrane transport;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding	NA	ATPase phospholipid transporting 8B2 [Source:HGNC Symbol%3BAcc:HGNC:13534]
ENSG00000168495	12.60	12.65	11.16	13.54	13.09	12.25	-0.0852917645249758	3.91944180419777	0.427223485399898	0.780059036094066	8:22245103-22254600:+	POLR3D	17;GO:0000790,cellular_component nuclear chromatin;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0016607,cellular_component nuclear speck;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0051607,biological_process defense response to virus	RPC4, POLR3D; DNA-directed RNA polymerase III subunit RPC4; K03026	RNA polymerase III subunit D [Source:HGNC Symbol%3BAcc:HGNC:1080]
ENSG00000086619	5.69	6.34	5.98	6.78	6.82	5.92	-0.107525779343927	3.15560937530913	0.427240829719726	0.780059036094066	1:236215554-236281985:-	ERO1B	19;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0006464,biological_process cellular protein modification process;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0019471,biological_process 4-hydroxyproline metabolic process;GO:0022417,biological_process protein maturation by protein folding;GO:0030070,biological_process insulin processing;GO:0030198,biological_process extracellular matrix organization;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0042593,biological_process glucose homeostasis;GO:0045454,biological_process cell redox homeostasis;GO:0051082,molecular_function unfolded protein binding;GO:0055114,biological_process oxidation-reduction process	ERO1LB; ERO1-like protein beta [EC:1.8.4.-]; K10976	endoplasmic reticulum oxidoreductase 1 beta [Source:HGNC Symbol%3BAcc:HGNC:14355]
ENSG00000105982	7.68	6.39	7.69	8.89	6.40	8.58	-0.115177875984711	3.21809316640937	0.427255704827733	0.780059036094066	7:156640280-156677130:+	RNF32	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0016235,cellular_component aggresome;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 32 [Source:HGNC Symbol%3BAcc:HGNC:17118]
ENSG00000168710	193.09	187.22	207.06	187.70	186.12	198.22	0.0503776034291567	8.26510353698958	0.427283616990425	0.780059036094066	1:109984685-110023741:+	AHCYL1	27;GO:0003723,molecular_function RNA binding;GO:0004013,molecular_function adenosylhomocysteinase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006378,biological_process mRNA polyadenylation;GO:0006611,biological_process protein export from nucleus;GO:0006730,biological_process one-carbon metabolic process;GO:0008150,biological_process biological_process;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0031440,biological_process regulation of mRNA 3'-end processing;GO:0032412,biological_process regulation of ion transmembrane transporter activity;GO:0033353,biological_process S-adenosylmethionine cycle;GO:0038166,biological_process angiotensin-activated signaling pathway;GO:0042045,biological_process epithelial fluid transport;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044070,biological_process regulation of anion transport;GO:0051592,biological_process response to calcium ion;GO:0070062,cellular_component extracellular exosome;GO:1903779,biological_process regulation of cardiac conduction	E3.3.1.1, ahcY; adenosylhomocysteinase [EC:3.3.1.1]; K01251	adenosylhomocysteinase like 1 [Source:HGNC Symbol%3BAcc:HGNC:344]
ENSG00000204316	41.14	39.57	40.09	40.59	42.31	43.55	-0.0533856646415141	5.5602262762469	0.427326306730013	0.780059036094066	17:75898642-75905413:-	MRPL38	7;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L38 [Source:HGNC Symbol%3BAcc:HGNC:14033]
ENSG00000167968	1.57	3.09	1.97	2.75	2.62	2.35	-0.246966769463263	1.18262111125681	0.427413391917389	0.78006305700758	16:2235815-2238711:+	DNASE1L2	15;GO:0001942,biological_process hair follicle development;GO:0003335,biological_process corneocyte development;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004536,molecular_function deoxyribonuclease activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006259,biological_process DNA metabolic process;GO:0006308,biological_process DNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	deoxyribonuclease 1 like 2 [Source:HGNC Symbol%3BAcc:HGNC:2958]
ENSG00000220201	4.34	1.76	2.72	2.58	2.05	2.94	0.2595188665557	1.27246262179316	0.427454194293528	0.78006305700758	19:10304802-10309880:-	ZGLP1	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048599,biological_process oocyte development	NA	zinc finger%2C GATA-like protein 1 [Source:HGNC Symbol%3BAcc:HGNC:37245]
ENSG00000147202	8.61	7.59	8.38	6.93	8.88	7.69	0.0810850505881115	4.76681855874808	0.427722896421269	0.780356127229583	X:96684662-97604997:+	DIAPH2	18;GO:0000910,biological_process cytokinesis;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007015,biological_process actin filament organization;GO:0007275,biological_process multicellular organism development;GO:0007292,biological_process female gamete generation;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030154,biological_process cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048477,biological_process oogenesis	DIAPH2; diaphanous 2; K05741	diaphanous related formin 2 [Source:HGNC Symbol%3BAcc:HGNC:2877]
ENSG00000204673	35.57	40.74	34.58	37.26	46.16	35.07	-0.0871484688467973	4.98895563982115	0.427744875255705	0.780356127229583	19:49869032-49878459:-	AKT1S1	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0031931,cellular_component TORC1 complex;GO:0032007,biological_process negative regulation of TOR signaling;GO:0038202,biological_process TORC1 signaling;GO:0042981,biological_process regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0045792,biological_process negative regulation of cell size;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:1900034,biological_process regulation of cellular response to heat	AKT1S1, PRAS40; proline-rich AKT1 substrate 1; K16184	AKT1 substrate 1 [Source:HGNC Symbol%3BAcc:HGNC:28426]
ENSG00000160193	9.89	8.58	8.75	11.02	7.85	10.81	-0.111043695551092	3.57591474756237	0.427803387238968	0.780356127229583	21:42843093-42879568:-	WDR4	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008176,molecular_function tRNA (guanine-N7-)-methyltransferase activity;GO:0036265,biological_process RNA (guanine-N7)-methylation;GO:0043527,cellular_component tRNA methyltransferase complex;GO:0106004,biological_process tRNA (guanine-N7)-methylation	NA	WD repeat domain 4 [Source:HGNC Symbol%3BAcc:HGNC:12756]
ENSG00000166946	36.68	31.42	36.06	32.47	34.08	34.19	0.0655807729334495	5.22182094507911	0.427955175192165	0.780518305856648	15:43185117-43197176:+	CCNDBP1	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0051726,biological_process regulation of cell cycle	NA	cyclin D1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1587]
ENSG00000134864	9.23	6.04	5.29	6.20	5.78	6.28	0.194950648886832	1.65053274197727	0.428178072328912	0.780810108978813	13:100530163-100589528:-	GGACT	6;GO:0003839,molecular_function gamma-glutamylcyclotransferase activity;GO:0005515,molecular_function protein binding;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0042219,biological_process cellular modified amino acid catabolic process;GO:0070062,cellular_component extracellular exosome	NA	gamma-glutamylamine cyclotransferase [Source:HGNC Symbol%3BAcc:HGNC:25100]
ENSG00000002016	7.53	6.75	8.03	7.22	7.03	6.87	0.0985818425205812	3.54340166557114	0.428363868438477	0.780984765352845	12:912076-990053:-	RAD52	19;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000730,biological_process DNA recombinase assembly;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010792,biological_process DNA double-strand break processing involved in repair via single-strand annealing;GO:0032993,cellular_component protein-DNA complex;GO:0034599,biological_process cellular response to oxidative stress;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0045002,biological_process double-strand break repair via single-strand annealing;GO:0051260,biological_process protein homooligomerization;GO:2000819,biological_process regulation of nucleotide-excision repair	RAD52; DNA repair and recombination protein RAD52; K10873	RAD52 homolog%2C DNA repair protein [Source:HGNC Symbol%3BAcc:HGNC:9824]
ENSG00000282936	1.16	1.27	1.54	1.25	1.67	1.53	-0.152633990819614	2.35854247372704	0.42839968317792	0.780984765352845	17:6636779-6640316:-	AC004706.4	NA	NA	NA
ENSG00000213853	57.80	54.94	64.93	62.92	60.40	64.56	-0.0650623665026004	4.94241459977159	0.428835847817459	0.78154783308128	16:10528421-10580698:-	EMP2	42;GO:0000139,cellular_component Golgi membrane;GO:0001765,biological_process membrane raft assembly;GO:0001913,biological_process T cell mediated cytotoxicity;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0003093,biological_process regulation of glomerular filtration;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007566,biological_process embryo implantation;GO:0008219,biological_process cell death;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010594,biological_process regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032060,biological_process bleb assembly;GO:0032147,biological_process activation of protein kinase activity;GO:0034394,biological_process protein localization to cell surface;GO:0043534,biological_process blood vessel endothelial cell migration;GO:0043549,biological_process regulation of kinase activity;GO:0045022,biological_process early endosome to late endosome transport;GO:0045121,cellular_component membrane raft;GO:0045177,cellular_component apical part of cell;GO:0045765,biological_process regulation of angiogenesis;GO:0070252,biological_process actin-mediated cell contraction;GO:0072659,biological_process protein localization to plasma membrane;GO:2001046,biological_process positive regulation of integrin-mediated signaling pathway;GO:2001212,biological_process regulation of vasculogenesis	NA	epithelial membrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:3334]
ENSG00000172301	41.05	41.66	40.56	40.18	37.43	41.28	0.0618384895830142	4.81807641237521	0.428885083199129	0.78154783308128	17:31851863-31859337:-	COPRS	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007517,biological_process muscle organ development;GO:0016569,biological_process covalent chromatin modification;GO:0042393,molecular_function histone binding;GO:0043985,biological_process histone H4-R3 methylation	NA	coordinator of PRMT5 and differentiation stimulator [Source:HGNC Symbol%3BAcc:HGNC:28848]
ENSG00000075568	16.23	13.84	16.16	15.90	15.56	17.14	-0.0580458933284681	6.48537987850158	0.428917498825631	0.78154783308128	2:97756332-97995891:-	TMEM131	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 131 [Source:HGNC Symbol%3BAcc:HGNC:30366]
ENSG00000107104	22.99	22.60	22.28	21.69	23.14	21.16	0.0525488147688969	6.56028095565208	0.428960395293866	0.78154783308128	9:470290-746106:+	KANK1	22;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008013,molecular_function beta-catenin binding;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030336,biological_process negative regulation of cell migration;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0032587,cellular_component ruffle membrane;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0042995,cellular_component cell projection;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0090303,biological_process positive regulation of wound healing;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:1900028,biological_process negative regulation of ruffle assembly;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000393,biological_process negative regulation of lamellipodium morphogenesis	NA	KN motif and ankyrin repeat domains 1 [Source:HGNC Symbol%3BAcc:HGNC:19309]
ENSG00000135698	23.91	25.51	24.49	24.47	26.26	28.29	-0.0901265595786255	3.73735389695504	0.429239815515562	0.781920463439225	16:82147797-82170226:-	MPHOSPH6	10;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000460,biological_process maturation of 5.8S rRNA;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing	MPHOSPH6, MPP6; M-phase phosphoprotein 6, animal type; K12593	M-phase phosphoprotein 6 [Source:HGNC Symbol%3BAcc:HGNC:7214]
ENSG00000013561	31.24	27.15	31.21	30.96	24.43	30.46	0.0762633502884142	5.38636745924682	0.429290901340395	0.781920463439225	5:141958327-141990291:+	RNF14	24;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0003713,molecular_function transcription coactivator activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 14 [Source:HGNC Symbol%3BAcc:HGNC:10058]
ENSG00000157911	15.98	16.94	16.13	17.00	18.55	16.46	-0.0747728539432263	4.28039534347456	0.429584807153046	0.782297519960126	1:2403963-2413797:-	PEX10	11;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0007031,biological_process peroxisome organization;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016558,biological_process protein import into peroxisome matrix;GO:0016567,biological_process protein ubiquitination;GO:0046872,molecular_function metal ion binding	PEX10; peroxin-10; K13346	peroxisomal biogenesis factor 10 [Source:HGNC Symbol%3BAcc:HGNC:8851]
ENSG00000162746	0.72	0.82	0.63	0.59	0.77	1.32	-0.310644541646938	0.251451994933138	0.429763227739808	0.782297519960126	1:161721562-161728143:+	FCRLB	3;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0050777,biological_process negative regulation of immune response	NA	Fc receptor like B [Source:HGNC Symbol%3BAcc:HGNC:26431]
ENSG00000211643	19.64	25.30	31.68	23.42	23.12	24.07	0.127910761904941	3.2199630483001	0.429777919725437	0.782297519960126	22:22318726-22319226:+	IGLV5-52	9;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002377,biological_process immunoglobulin production;GO:0003823,molecular_function antigen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0016020,cellular_component membrane	NA	immunoglobulin lambda variable 5-52 [Source:HGNC Symbol%3BAcc:HGNC:5926]
ENSG00000187792	3.11	3.43	3.74	3.92	3.51	3.94	-0.136377377658359	2.31899447240607	0.429857398902792	0.782297519960126	22:23738677-23751092:-	ZNF70	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 70 [Source:HGNC Symbol%3BAcc:HGNC:13140]
ENSG00000125247	5.40	6.72	5.66	4.89	6.30	5.46	0.0970221019750662	3.80433775894831	0.429863608089436	0.782297519960126	13:100603926-100675093:-	TMTC4	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane and tetratricopeptide repeat containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25904]
ENSG00000137171	18.91	18.85	17.13	19.20	19.48	18.89	-0.0585418144104746	5.31429669137048	0.430060527200547	0.782297519960126	6:43040776-43075099:+	KLC4	6;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule	KLC; kinesin light chain; K10407	kinesin light chain 4 [Source:HGNC Symbol%3BAcc:HGNC:21624]
ENSG00000155744	2.15	1.86	1.92	2.46	2.49	1.79	-0.161624197829899	1.86194003699785	0.430104631515369	0.782297519960126	2:200973717-201071671:-	FAM126B	6;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	family with sequence similarity 126 member B [Source:HGNC Symbol%3BAcc:HGNC:28593]
ENSG00000115226	13.58	13.48	12.58	13.33	12.53	11.32	0.104375852141955	3.19019038606763	0.430147518401832	0.782297519960126	2:27491882-27495245:-	FNDC4	4;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	fibronectin type III domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:20239]
ENSG00000183696	81.06	54.93	82.06	95.50	59.53	84.47	-0.122033554090452	6.27405583777202	0.430148458470643	0.782297519960126	7:48088627-48108733:+	UPP1	17;GO:0003824,molecular_function catalytic activity;GO:0004850,molecular_function uridine phosphorylase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006218,biological_process uridine catabolic process;GO:0006220,biological_process pyrimidine nucleotide metabolic process;GO:0009116,biological_process nucleoside metabolic process;GO:0009166,biological_process nucleotide catabolic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016763,molecular_function transferase activity, transferring pentosyl groups;GO:0042149,biological_process cellular response to glucose starvation;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0044206,biological_process UMP salvage;GO:0046108,biological_process uridine metabolic process;GO:0046135,biological_process pyrimidine nucleoside catabolic process	udp, UPP; uridine phosphorylase [EC:2.4.2.3]; K00757	uridine phosphorylase 1 [Source:HGNC Symbol%3BAcc:HGNC:12576]
ENSG00000154889	23.15	21.08	20.85	16.68	22.05	23.05	0.0873117727041723	4.81672475153306	0.430163009808838	0.782297519960126	18:11882621-11909223:-	MPPE1	20;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034235,molecular_function GPI anchor binding;GO:0046872,molecular_function metal ion binding;GO:0070971,cellular_component endoplasmic reticulum exit site	NA	metallophosphoesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:15988]
ENSG00000173846	3.75	3.01	3.68	4.13	4.50	3.01	-0.131866950180206	2.87121776663656	0.430191160174641	0.782297519960126	1:44800224-44805990:+	PLK3	44;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000302,biological_process response to reactive oxygen species;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006970,biological_process response to osmotic stress;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007113,biological_process endomitotic cell cycle;GO:0009314,biological_process response to radiation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030425,cellular_component dendrite;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0032465,biological_process regulation of cytokinesis;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043491,biological_process protein kinase B signaling;GO:0044819,biological_process mitotic G1/S transition checkpoint;GO:0051302,biological_process regulation of cell division;GO:0090166,biological_process Golgi disassembly;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904716,biological_process positive regulation of chaperone-mediated autophagy;GO:2000777,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia	PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]; K08862	polo like kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:2154]
ENSG00000171791	3.69	3.84	3.25	2.81	3.15	3.48	0.193175961456745	1.41188051781131	0.430359326265804	0.7824343588459	18:63123345-63320128:-	BCL2	172;GO:0000209,biological_process protein polyubiquitination;GO:0000902,biological_process cell morphogenesis;GO:0001503,biological_process ossification;GO:0001541,biological_process ovarian follicle development;GO:0001656,biological_process metanephros development;GO:0001657,biological_process ureteric bud development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001662,biological_process behavioral fear response;GO:0001776,biological_process leukocyte homeostasis;GO:0001782,biological_process B cell homeostasis;GO:0001822,biological_process kidney development;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0002020,molecular_function protease binding;GO:0002260,biological_process lymphocyte homeostasis;GO:0002320,biological_process lymphoid progenitor cell differentiation;GO:0002326,biological_process B cell lineage commitment;GO:0002360,biological_process T cell lineage commitment;GO:0002520,biological_process immune system development;GO:0002931,biological_process response to ischemia;GO:0003014,biological_process renal system process;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006582,biological_process melanin metabolic process;GO:0006808,biological_process regulation of nitrogen utilization;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006915,biological_process apoptotic process;GO:0006959,biological_process humoral immune response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007015,biological_process actin filament organization;GO:0007409,biological_process axonogenesis;GO:0007565,biological_process female pregnancy;GO:0007569,biological_process cell aging;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009314,biological_process response to radiation;GO:0009636,biological_process response to toxic substance;GO:0009791,biological_process post-embryonic development;GO:0009887,biological_process organ morphogenesis;GO:0010039,biological_process response to iron ion;GO:0010224,biological_process response to UV-B;GO:0010332,biological_process response to gamma radiation;GO:0010468,biological_process regulation of gene expression;GO:0010506,biological_process regulation of autophagy;GO:0010507,biological_process negative regulation of autophagy;GO:0010523,biological_process negative regulation of calcium ion transport into cytosol;GO:0010559,biological_process regulation of glycoprotein biosynthetic process;GO:0014031,biological_process mesenchymal cell development;GO:0014042,biological_process positive regulation of neuron maturation;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0015267,molecular_function channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0016248,molecular_function channel inhibitor activity;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019903,molecular_function protein phosphatase binding;GO:0021747,biological_process cochlear nucleus development;GO:0022612,biological_process gland morphogenesis;GO:0022898,biological_process regulation of transmembrane transporter activity;GO:0030097,biological_process hemopoiesis;GO:0030183,biological_process B cell differentiation;GO:0030217,biological_process T cell differentiation;GO:0030279,biological_process negative regulation of ossification;GO:0030307,biological_process positive regulation of cell growth;GO:0030308,biological_process negative regulation of cell growth;GO:0030318,biological_process melanocyte differentiation;GO:0030336,biological_process negative regulation of cell migration;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031069,biological_process hair follicle morphogenesis;GO:0031103,biological_process axon regeneration;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0031965,cellular_component nuclear membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0032835,biological_process glomerulus development;GO:0032848,biological_process negative regulation of cellular pH reduction;GO:0032880,biological_process regulation of protein localization;GO:0033033,biological_process negative regulation of myeloid cell apoptotic process;GO:0033077,biological_process T cell differentiation in thymus;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033689,biological_process negative regulation of osteoblast proliferation;GO:0034097,biological_process response to cytokine;GO:0035094,biological_process response to nicotine;GO:0035265,biological_process organ growth;GO:0040007,biological_process growth;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042100,biological_process B cell proliferation;GO:0042149,biological_process cellular response to glucose starvation;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043029,biological_process T cell homeostasis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043067,biological_process regulation of programmed cell death;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043375,biological_process CD8-positive, alpha-beta T cell lineage commitment;GO:0043473,biological_process pigmentation;GO:0043496,biological_process regulation of protein homodimerization activity;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043583,biological_process ear development;GO:0045069,biological_process regulation of viral genome replication;GO:0045636,biological_process positive regulation of melanocyte differentiation;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0046671,biological_process negative regulation of retinal cell programmed cell death;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0046930,cellular_component pore complex;GO:0046982,molecular_function protein heterodimerization activity;GO:0048041,biological_process focal adhesion assembly;GO:0048066,biological_process developmental pigmentation;GO:0048070,biological_process regulation of developmental pigmentation;GO:0048087,biological_process positive regulation of developmental pigmentation;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0048545,biological_process response to steroid hormone;GO:0048546,biological_process digestive tract morphogenesis;GO:0048589,biological_process developmental growth;GO:0048599,biological_process oocyte development;GO:0048743,biological_process positive regulation of skeletal muscle fiber development;GO:0048753,biological_process pigment granule organization;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050790,biological_process regulation of catalytic activity;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051384,biological_process response to glucocorticoid;GO:0051402,biological_process neuron apoptotic process;GO:0051434,molecular_function BH3 domain binding;GO:0051607,biological_process defense response to virus;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0051726,biological_process regulation of cell cycle;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0051902,biological_process negative regulation of mitochondrial depolarization;GO:0051924,biological_process regulation of calcium ion transport;GO:0055085,biological_process transmembrane transport;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071310,biological_process cellular response to organic substance;GO:0071456,biological_process cellular response to hypoxia;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2000811,biological_process negative regulation of anoikis;GO:2001234,biological_process negative regulation of apoptotic signaling pathway;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BCL2; apoptosis regulator Bcl-2; K02161	BCL2%2C apoptosis regulator [Source:HGNC Symbol%3BAcc:HGNC:990]
ENSG00000186314	14.73	15.36	11.70	15.87	15.30	14.30	-0.116983364973552	3.11184952876332	0.430447047042729	0.7824343588459	5:145471798-145835369:-	PRELID2	4;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0015914,biological_process phospholipid transport;GO:1990050,molecular_function phosphatidic acid transporter activity	NA	PRELI domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28306]
ENSG00000213918	4.33	5.04	5.22	3.70	5.55	3.86	0.164973131177291	2.14561290668943	0.430455509269206	0.7824343588459	16:3611727-3680143:+	DNASE1	14;GO:0003779,molecular_function actin binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004530,molecular_function deoxyribonuclease I activity;GO:0004536,molecular_function deoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0006308,biological_process DNA catabolic process;GO:0006915,biological_process apoptotic process;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	deoxyribonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:2956]
ENSG00000126756	70.21	68.99	59.37	69.85	69.56	69.76	-0.0654469306670372	5.11336852809855	0.430628072759744	0.78256791179844	X:47651797-47659161:-	UXT	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000930,cellular_component gamma-tubulin complex;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007098,biological_process centrosome cycle;GO:0008017,molecular_function microtubule binding;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0048487,molecular_function beta-tubulin binding	NA	ubiquitously expressed prefoldin like chaperone [Source:HGNC Symbol%3BAcc:HGNC:12641]
ENSG00000183401	9.94	8.60	10.50	9.54	8.64	9.23	0.105015486130699	3.32344746988946	0.430726776948659	0.78256791179844	19:11344683-11354944:+	CCDC159	NA	NA	coiled-coil domain containing 159 [Source:HGNC Symbol%3BAcc:HGNC:26996]
ENSG00000123095	64.76	57.96	68.51	62.65	57.69	64.77	0.0607621097729924	6.50765989353817	0.430757273046672	0.78256791179844	12:26120025-26125127:-	BHLHE41	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001191,molecular_function transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007623,biological_process circadian rhythm;GO:0008283,biological_process cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0010944,biological_process negative regulation of transcription by competitive promoter binding;GO:0030154,biological_process cell differentiation;GO:0032922,biological_process circadian regulation of gene expression;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043426,molecular_function MRF binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0070888,molecular_function E-box binding	BHLHB3, DEC2; class B basic helix-loop-helix protein 3; K03730	basic helix-loop-helix family member e41 [Source:HGNC Symbol%3BAcc:HGNC:16617]
ENSG00000196531	77.71	75.64	80.55	77.90	73.44	76.93	0.0470881621166261	8.91274734525694	0.430781160180355	0.78256791179844	12:56712427-56731628:-	NACA	22;GO:0003231,biological_process cardiac ventricle development;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005854,cellular_component nascent polypeptide-associated complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006412,biological_process translation;GO:0006810,biological_process transport;GO:0010664,biological_process negative regulation of striated muscle cell apoptotic process;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0048633,biological_process positive regulation of skeletal muscle tissue growth;GO:0048742,biological_process regulation of skeletal muscle fiber development;GO:0061384,biological_process heart trabecula morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:1901227,biological_process negative regulation of transcription from RNA polymerase II promoter involved in heart development;GO:1901228,biological_process positive regulation of transcription from RNA polymerase II promoter involved in heart development;GO:2000138,biological_process positive regulation of cell proliferation involved in heart morphogenesis	EGD2, NACA; nascent polypeptide-associated complex subunit alpha; K03626	nascent polypeptide-associated complex alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:7629]
ENSG00000169057	15.31	15.90	14.03	15.67	17.48	14.81	-0.0747500039943896	4.64799468835797	0.430867685373045	0.78261056168212	X:154021572-154137103:-	MECP2	87;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000792,cellular_component heterochromatin;GO:0000930,cellular_component gamma-tubulin complex;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001662,biological_process behavioral fear response;GO:0001666,biological_process response to hypoxia;GO:0001964,biological_process startle response;GO:0001976,biological_process neurological system process involved in regulation of systemic arterial blood pressure;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006020,biological_process inositol metabolic process;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0006342,biological_process chromatin silencing;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006541,biological_process glutamine metabolic process;GO:0006576,biological_process cellular biogenic amine metabolic process;GO:0007052,biological_process mitotic spindle organization;GO:0007268,biological_process chemical synaptic transmission;GO:0007416,biological_process synapse assembly;GO:0007420,biological_process brain development;GO:0007585,biological_process respiratory gaseous exchange;GO:0007612,biological_process learning;GO:0007613,biological_process memory;GO:0007616,biological_process long-term memory;GO:0007626,biological_process locomotory behavior;GO:0008104,biological_process protein localization;GO:0008134,molecular_function transcription factor binding;GO:0008211,biological_process glucocorticoid metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008327,molecular_function methyl-CpG binding;GO:0008344,biological_process adult locomotory behavior;GO:0008542,biological_process visual learning;GO:0009314,biological_process response to radiation;GO:0009405,biological_process pathogenesis;GO:0009791,biological_process post-embryonic development;GO:0010385,molecular_function double-stranded methylated DNA binding;GO:0010468,biological_process regulation of gene expression;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016358,biological_process dendrite development;GO:0016571,biological_process histone methylation;GO:0016573,biological_process histone acetylation;GO:0019230,biological_process proprioception;GO:0019233,biological_process sensory perception of pain;GO:0019904,molecular_function protein domain specific binding;GO:0021549,biological_process cerebellum development;GO:0021591,biological_process ventricular system development;GO:0030182,biological_process neuron differentiation;GO:0031061,biological_process negative regulation of histone methylation;GO:0031175,biological_process neuron projection development;GO:0032048,biological_process cardiolipin metabolic process;GO:0033555,biological_process multicellular organismal response to stress;GO:0035067,biological_process negative regulation of histone acetylation;GO:0035176,biological_process social behavior;GO:0035197,molecular_function siRNA binding;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042551,biological_process neuron maturation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046470,biological_process phosphatidylcholine metabolic process;GO:0047485,molecular_function protein N-terminus binding;GO:0048167,biological_process regulation of synaptic plasticity;GO:0050432,biological_process catecholamine secretion;GO:0050884,biological_process neuromuscular process controlling posture;GO:0050905,biological_process neuromuscular process;GO:0051151,biological_process negative regulation of smooth muscle cell differentiation;GO:0051965,biological_process positive regulation of synapse assembly;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060291,biological_process long-term synaptic potentiation;GO:0090063,biological_process positive regulation of microtubule nucleation;GO:0098794,cellular_component postsynapse;GO:1900114,biological_process positive regulation of histone H3-K9 trimethylation;GO:2000820,biological_process negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	NA	methyl-CpG binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6990]
ENSG00000125818	87.32	86.27	95.82	97.10	90.20	94.86	-0.0538568947346655	6.49293311703748	0.431028630108942	0.782788351944739	20:1113262-1189415:+	PSMF1	40;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070628,molecular_function proteasome binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901799,biological_process negative regulation of proteasomal protein catabolic process;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMF1; proteasome inhibitor subunit 1 (PI31); K06700	proteasome inhibitor subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:9571]
ENSG00000173276	4.46	5.08	4.79	4.61	4.34	4.66	0.0781719921487504	3.90859870094341	0.431216200836754	0.78300922000235	21:41986830-42010387:-	ZBTB21	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008327,molecular_function methyl-CpG binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 21 [Source:HGNC Symbol%3BAcc:HGNC:13083]
ENSG00000002919	17.62	19.00	17.43	16.78	18.48	16.17	0.0797720250837792	3.94624686973082	0.43127640676356	0.78300922000235	17:48103356-48123074:+	SNX11	13;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0019898,cellular_component extrinsic component of membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:1901981,molecular_function phosphatidylinositol phosphate binding	NA	sorting nexin 11 [Source:HGNC Symbol%3BAcc:HGNC:14975]
ENSG00000185437	6.56	4.26	5.15	5.24	4.15	5.10	0.168880723092947	2.06188435494944	0.4314105070936	0.783138143397611	21:39445854-39515506:+	SH3BGR	5;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005829,cellular_component cytosol;GO:0006461,biological_process protein complex assembly;GO:0009967,biological_process positive regulation of signal transduction;GO:0017124,molecular_function SH3 domain binding	NA	SH3 domain binding glutamate rich protein [Source:HGNC Symbol%3BAcc:HGNC:10822]
ENSG00000171827	2.83	3.06	2.12	3.00	2.79	3.08	-0.148315526779684	2.43589303050829	0.431625879993922	0.783414541360514	19:37467584-37488652:+	ZNF570	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 570 [Source:HGNC Symbol%3BAcc:HGNC:26416]
ENSG00000147164	119.73	120.87	128.14	109.53	128.14	119.61	0.0579345911655352	5.99354690716861	0.431743417716283	0.783513310542723	X:71056331-71073426:-	SNX12	17;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0010629,biological_process negative regulation of gene expression;GO:0010955,biological_process negative regulation of protein processing;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0019898,cellular_component extrinsic component of membrane;GO:0019899,molecular_function enzyme binding;GO:0030100,biological_process regulation of endocytosis;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0051224,biological_process negative regulation of protein transport;GO:0070062,cellular_component extracellular exosome;GO:2000642,biological_process negative regulation of early endosome to late endosome transport	NA	sorting nexin 12 [Source:HGNC Symbol%3BAcc:HGNC:14976]
ENSG00000040341	41.17	45.57	41.13	42.93	45.05	45.72	-0.0552750843739839	6.44146632985437	0.432112279026686	0.783847674300993	8:73420368-73747708:-	STAU2	10;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane	NA	staufen double-stranded RNA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11371]
ENSG00000102393	21.88	25.38	24.53	22.39	24.47	22.10	0.0658184746642184	4.95117368356381	0.43220158396638	0.783847674300993	X:101397802-101407925:-	GLA	27;GO:0003824,molecular_function catalytic activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004557,molecular_function alpha-galactosidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016139,biological_process glycoside catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016936,molecular_function galactoside binding;GO:0035578,cellular_component azurophil granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0046477,biological_process glycosylceramide catabolic process;GO:0046479,biological_process glycosphingolipid catabolic process;GO:0051001,biological_process negative regulation of nitric-oxide synthase activity;GO:0052692,molecular_function raffinose alpha-galactosidase activity;GO:0070062,cellular_component extracellular exosome	GLA; alpha-galactosidase [EC:3.2.1.22]; K01189	galactosidase alpha [Source:HGNC Symbol%3BAcc:HGNC:4296]
ENSG00000172379	4.69	4.18	4.05	4.16	3.18	4.66	0.117384756944888	3.22944690422869	0.43225000168885	0.783847674300993	15:80404349-80597937:+	ARNT2	26;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006805,biological_process xenobiotic metabolic process;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0032355,biological_process response to estradiol;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity	ARNT2; aryl hydrocarbon receptor nuclear translocator 2; K15589	aryl hydrocarbon receptor nuclear translocator 2 [Source:HGNC Symbol%3BAcc:HGNC:16876]
ENSG00000136877	36.86	36.63	40.92	37.20	37.90	36.02	0.0555004539858764	6.05310466737803	0.432298096413762	0.783847674300993	9:127794596-127814327:+	FPGS	22;GO:0000166,molecular_function nucleotide binding;GO:0001889,biological_process liver development;GO:0004326,molecular_function tetrahydrofolylpolyglutamate synthase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006730,biological_process one-carbon metabolic process;GO:0006760,biological_process folic acid-containing compound metabolic process;GO:0007420,biological_process brain development;GO:0009058,biological_process biosynthetic process;GO:0009396,biological_process folic acid-containing compound biosynthetic process;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0031100,biological_process organ regeneration;GO:0046655,biological_process folic acid metabolic process;GO:0046872,molecular_function metal ion binding;GO:0046901,biological_process tetrahydrofolylpolyglutamate biosynthetic process	FPGS; folylpolyglutamate synthase [EC:6.3.2.17]; K01930	folylpolyglutamate synthase [Source:HGNC Symbol%3BAcc:HGNC:3824]
ENSG00000230453	3.75	3.67	3.48	3.47	4.39	3.89	-0.0952647942634193	3.59033701888291	0.432300611502994	0.783847674300993	9:33524393-33573009:+	ANKRD18B	NA	NA	ankyrin repeat domain 18B [Source:HGNC Symbol%3BAcc:HGNC:23644]
ENSG00000152779	3.70	5.25	3.57	4.45	5.73	3.77	-0.158496149596766	2.79076850258135	0.432306547834093	0.783847674300993	10:89430298-89556641:-	SLC16A12	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 16 member 12 [Source:HGNC Symbol%3BAcc:HGNC:23094]
ENSG00000168938	94.50	112.39	91.54	88.17	107.32	90.11	0.0720738052920547	5.95337993453291	0.432409248550218	0.783919381079868	5:123023249-123036741:-	PPIC	8;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006457,biological_process protein folding;GO:0016018,molecular_function cyclosporin A binding;GO:0016853,molecular_function isomerase activity;GO:0070062,cellular_component extracellular exosome	NA	peptidylprolyl isomerase C [Source:HGNC Symbol%3BAcc:HGNC:9256]
ENSG00000178685	26.34	20.52	26.90	27.13	22.83	28.73	-0.0788540652585468	6.31365142309409	0.432484820408857	0.783941891900575	8:143977152-144012772:-	PARP10	22;GO:0003676,molecular_function nucleic acid binding;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006471,biological_process protein ADP-ribosylation;GO:0010629,biological_process negative regulation of gene expression;GO:0010847,biological_process regulation of chromatin assembly;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0033159,biological_process negative regulation of protein import into nucleus, translocation;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045071,biological_process negative regulation of viral genome replication;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0070212,biological_process protein poly-ADP-ribosylation;GO:0070213,biological_process protein auto-ADP-ribosylation;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:1900045,biological_process negative regulation of protein K63-linked ubiquitination	NA	poly(ADP-ribose) polymerase family member 10 [Source:HGNC Symbol%3BAcc:HGNC:25895]
ENSG00000114395	8.59	11.62	9.28	7.19	9.45	10.14	0.134520643068703	2.66814558903756	0.432707471472973	0.784214051174621	3:50350694-50358460:+	CYB561D2	4;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	NA
ENSG00000171984	3.24	3.50	2.31	4.41	2.98	3.13	-0.216343023971474	1.39814661825377	0.432761318822698	0.784214051174621	20:5750392-5863912:+	C20orf196	NA	NA	chromosome 20 open reading frame 196 [Source:HGNC Symbol%3BAcc:HGNC:26318]
ENSG00000136643	10.23	9.86	10.54	9.29	10.13	10.20	0.0616984391169569	5.01344058077356	0.432887173662479	0.784264694683477	1:213051232-213274773:+	RPS6KC1	14;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035091,molecular_function phosphatidylinositol binding	NA	ribosomal protein S6 kinase C1 [Source:HGNC Symbol%3BAcc:HGNC:10439]
ENSG00000087074	79.21	53.14	80.58	89.51	60.26	82.93	-0.115683472606029	7.36595064711374	0.432915627807233	0.784264694683477	19:48872391-48876057:+	PPP1R15A	39;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032058,biological_process positive regulation of translational initiation in response to stress;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035308,biological_process negative regulation of protein dephosphorylation;GO:0036496,biological_process regulation of translational initiation by eIF2 alpha dephosphorylation;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:0060734,biological_process regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070262,biological_process peptidyl-serine dephosphorylation;GO:0070972,biological_process protein localization to endoplasmic reticulum;GO:0072542,molecular_function protein phosphatase activator activity;GO:1902310,biological_process positive regulation of peptidyl-serine dephosphorylation;GO:1903573,biological_process negative regulation of response to endoplasmic reticulum stress;GO:1903898,biological_process negative regulation of PERK-mediated unfolded protein response;GO:1903912,biological_process negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:1903917,biological_process positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation;GO:1990441,biological_process negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PPP1R15A, GADD34; protein phosphatase 1 regulatory subunit 15A; K14019	protein phosphatase 1 regulatory subunit 15A [Source:HGNC Symbol%3BAcc:HGNC:14375]
ENSG00000122477	10.63	9.82	10.46	10.22	9.14	9.86	0.0968260617885369	3.44497892759918	0.433290099463814	0.784702895116731	1:100148448-100178273:-	LRRC39	NA	NA	leucine rich repeat containing 39 [Source:HGNC Symbol%3BAcc:HGNC:28228]
ENSG00000120158	14.39	13.38	14.65	13.74	11.44	15.09	0.0878403261007997	4.16313441915421	0.433330021591034	0.784702895116731	9:4792868-4885917:+	RCL1	12;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479,biological_process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480,biological_process endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003824,molecular_function catalytic activity;GO:0004521,molecular_function endoribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0008150,biological_process biological_process;GO:0042254,biological_process ribosome biogenesis	RCL1; RNA 3'-terminal phosphate cyclase-like protein; K11108	RNA terminal phosphate cyclase like 1 [Source:HGNC Symbol%3BAcc:HGNC:17687]
ENSG00000109089	8.30	7.60	8.86	9.55	8.26	8.87	-0.0893508640168195	3.60390442858888	0.433347163943059	0.784702895116731	17:74987631-75005800:+	CDR2L	1;GO:0005515,molecular_function protein binding	NA	cerebellar degeneration related protein 2 like [Source:HGNC Symbol%3BAcc:HGNC:29999]
ENSG00000123892	21.51	23.93	19.72	20.39	18.88	22.24	0.0853620325332225	3.86160435197761	0.433563366611286	0.784979881818246	11:88113241-88175467:-	RAB38	38;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006996,biological_process organelle organization;GO:0007005,biological_process mitochondrion organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0033162,cellular_component melanosome membrane;GO:0035646,biological_process endosome to melanosome transport;GO:0035650,molecular_function AP-1 adaptor complex binding;GO:0035651,molecular_function AP-3 adaptor complex binding;GO:0036461,molecular_function BLOC-2 complex binding;GO:0042470,cellular_component melanosome;GO:0043687,biological_process post-translational protein modification;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0045335,cellular_component phagocytic vesicle;GO:0060155,biological_process platelet dense granule organization;GO:0061024,biological_process membrane organization;GO:0072657,biological_process protein localization to membrane;GO:0090383,biological_process phagosome acidification;GO:1903232,biological_process melanosome assembly	NA	RAB38%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9776]
ENSG00000168522	39.64	36.37	37.98	37.53	34.92	38.12	0.0578430801456902	5.43590827388334	0.433786124171738	0.784993370370449	8:43034193-43085788:+	FNTA	30;GO:0004659,molecular_function prenyltransferase activity;GO:0004660,molecular_function protein farnesyltransferase activity;GO:0004661,molecular_function protein geranylgeranyltransferase activity;GO:0004662,molecular_function CAAX-protein geranylgeranyltransferase activity;GO:0004663,molecular_function Rab geranylgeranyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0005953,cellular_component CAAX-protein geranylgeranyltransferase complex;GO:0005965,cellular_component protein farnesyltransferase complex;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007528,biological_process neuromuscular junction development;GO:0008017,molecular_function microtubule binding;GO:0008318,molecular_function protein prenyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018342,biological_process protein prenylation;GO:0018343,biological_process protein farnesylation;GO:0018344,biological_process protein geranylgeranylation;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0030548,molecular_function acetylcholine receptor regulator activity;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0043014,molecular_function alpha-tubulin binding;GO:0045213,biological_process neurotransmitter receptor metabolic process;GO:0071340,biological_process skeletal muscle acetylcholine-gated channel clustering;GO:0090044,biological_process positive regulation of tubulin deacetylation;GO:0090045,biological_process positive regulation of deacetylase activity;GO:0097194,biological_process execution phase of apoptosis;GO:0099601,biological_process regulation of neurotransmitter receptor activity	FNTA; protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [EC:2.5.1.58 2.5.1.59]; K05955	farnesyltransferase%2C CAAX box%2C alpha [Source:HGNC Symbol%3BAcc:HGNC:3782]
ENSG00000165006	78.10	74.08	82.95	83.31	83.43	79.13	-0.0513950260686823	7.12625167527024	0.433792241516832	0.784993370370449	9:34179004-34252523:+	UBAP1	16;GO:0000813,cellular_component ESCRT I complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016197,biological_process endosomal transport;GO:0019058,biological_process viral life cycle;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043657,cellular_component host cell;GO:0075733,biological_process intracellular transport of virus	NA	ubiquitin associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:12461]
ENSG00000132434	9.47	9.70	8.56	9.54	9.94	10.16	-0.0892935449894566	3.70723097195328	0.433831925095006	0.784993370370449	7:55365447-55433742:+	LANCL2	14;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0009789,biological_process positive regulation of abscisic acid-activated signaling pathway;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0016020,cellular_component membrane;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	LanC like 2 [Source:HGNC Symbol%3BAcc:HGNC:6509]
ENSG00000100865	50.77	43.52	44.93	45.29	45.88	43.31	0.0667119399682551	5.06431348417025	0.433834492930064	0.784993370370449	14:102341101-102362916:-	CINP	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0051301,biological_process cell division	NA	cyclin dependent kinase 2 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:23789]
ENSG00000135480	1.20	0.61	0.58	0.85	0.65	1.55	-0.320611497070928	0.541116263114949	0.433887014751603	0.784993370370449	12:52232519-52252186:+	KRT7	11;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0016032,biological_process viral process;GO:0031424,biological_process keratinization;GO:0045095,cellular_component keratin filament;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification	NA	keratin 7 [Source:HGNC Symbol%3BAcc:HGNC:6445]
ENSG00000163191	1451.98	1450.47	1419.68	1409.26	1420.54	1396.32	0.0441094977886955	8.81134387719389	0.433993275618902	0.785071193567099	1:152032505-152047907:-	S100A11	21;GO:0001726,cellular_component ruffle;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005913,cellular_component cell-cell adherens junction;GO:0007165,biological_process signal transduction;GO:0008156,biological_process negative regulation of DNA replication;GO:0008285,biological_process negative regulation of cell proliferation;GO:0034774,cellular_component secretory granule lumen;GO:0042127,biological_process regulation of cell proliferation;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0044548,molecular_function S100 protein binding;GO:0046872,molecular_function metal ion binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0070062,cellular_component extracellular exosome;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	NA	S100 calcium binding protein A11 [Source:HGNC Symbol%3BAcc:HGNC:10488]
ENSG00000115128	290.98	284.66	298.72	285.11	285.17	282.21	0.0490527706511588	6.75704703862196	0.434150367195051	0.785240930787144	2:24067583-24076443:-	SF3B6	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001825,biological_process blastocyst formation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005684,cellular_component U2-type spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	splicing factor 3b subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:30096]
ENSG00000161526	60.22	58.87	58.66	61.26	62.66	61.51	-0.0487264898861672	6.10405563048934	0.434542783143572	0.785651995123345	17:75667115-75708062:+	SAP30BP	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0010942,biological_process positive regulation of cell death;GO:0045111,cellular_component intermediate filament cytoskeleton	NA	SAP30 binding protein [Source:HGNC Symbol%3BAcc:HGNC:30785]
ENSG00000088766	58.62	63.29	51.97	59.93	64.70	58.37	-0.0651698481986042	5.76467458839874	0.434545756926056	0.785651995123345	20:6006089-6040053:+	CRLS1	18;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006629,biological_process lipid metabolic process;GO:0008444,molecular_function CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0008808,molecular_function cardiolipin synthase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016780,molecular_function phosphotransferase activity, for other substituted phosphate groups;GO:0031966,cellular_component mitochondrial membrane;GO:0032049,biological_process cardiolipin biosynthetic process;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0043337,molecular_function CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0097068,biological_process response to thyroxine;GO:1905711,biological_process response to phosphatidylethanolamine	CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41]; K08744	cardiolipin synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:16148]
ENSG00000096070	8.26	7.21	7.16	7.84	7.76	8.30	-0.0646503011756036	4.85817667759276	0.43461069957032	0.785651995123345	6:36196743-36232790:+	BRPF3	8;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0016569,biological_process covalent chromatin modification;GO:0043966,biological_process histone H3 acetylation;GO:0046872,molecular_function metal ion binding;GO:0070776,cellular_component MOZ/MORF histone acetyltransferase complex	NA	bromodomain and PHD finger containing 3 [Source:HGNC Symbol%3BAcc:HGNC:14256]
ENSG00000205531	109.86	111.33	108.08	111.00	116.85	115.33	-0.0483038923057157	7.08103259245059	0.434630810481915	0.785651995123345	11:2944430-2992377:-	NAP1L4	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006334,biological_process nucleosome assembly;GO:0031491,molecular_function nucleosome binding;GO:0051082,molecular_function unfolded protein binding	NA	nucleosome assembly protein 1 like 4 [Source:HGNC Symbol%3BAcc:HGNC:7640]
ENSG00000174125	0.33	0.45	0.25	0.38	0.42	0.48	-0.337720215339969	0.0724834906270646	0.434827492351931	0.785833490897262	4:38790676-38856817:-	TLR1	35;GO:0001775,biological_process cell activation;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034130,biological_process toll-like receptor 1 signaling pathway;GO:0034137,biological_process positive regulation of toll-like receptor 2 signaling pathway;GO:0035354,cellular_component Toll-like receptor 1-Toll-like receptor 2 protein complex;GO:0035663,molecular_function Toll-like receptor 2 binding;GO:0038123,biological_process toll-like receptor TLR1:TLR2 signaling pathway;GO:0042116,biological_process macrophage activation;GO:0042495,biological_process detection of triacyl bacterial lipopeptide;GO:0042535,biological_process positive regulation of tumor necrosis factor biosynthetic process;GO:0042742,biological_process defense response to bacterium;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045410,biological_process positive regulation of interleukin-6 biosynthetic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0050707,biological_process regulation of cytokine secretion;GO:0071723,molecular_function lipopeptide binding;GO:0071727,biological_process cellular response to triacyl bacterial lipopeptide;GO:2000484,biological_process positive regulation of interleukin-8 secretion	TLR1, CD281; toll-like receptor 1; K05398	toll like receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:11847]
ENSG00000108510	11.59	11.08	11.64	11.96	11.70	12.15	-0.0484231441129365	6.26401441618762	0.434857830417569	0.785833490897262	17:61942604-62065282:-	MED13	22;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004872,molecular_function receptor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016592,cellular_component mediator complex;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042632,biological_process cholesterol homeostasis;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0070328,biological_process triglyceride homeostasis;GO:1904168,biological_process negative regulation of thyroid hormone receptor activity	MED13; mediator of RNA polymerase II transcription subunit 13; K15164	mediator complex subunit 13 [Source:HGNC Symbol%3BAcc:HGNC:22474]
ENSG00000127191	22.13	22.70	21.45	22.22	24.17	23.16	-0.059558794032014	5.09539233288907	0.435039612722768	0.785958294607136	9:136881911-136926607:+	TRAF2	74;GO:0000151,cellular_component ubiquitin ligase complex;GO:0002726,biological_process positive regulation of T cell cytokine production;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005102,molecular_function receptor binding;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005174,molecular_function CD40 receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005938,cellular_component cell cortex;GO:0006461,biological_process protein complex assembly;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0008270,molecular_function zinc ion binding;GO:0008289,molecular_function lipid binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0012506,cellular_component vesicle membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030163,biological_process protein catabolic process;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031996,molecular_function thioesterase binding;GO:0032403,molecular_function protein complex binding;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034351,biological_process negative regulation of glial cell apoptotic process;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035631,cellular_component CD40 receptor complex;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043623,biological_process cellular protein complex assembly;GO:0045121,cellular_component membrane raft;GO:0046328,biological_process regulation of JNK cascade;GO:0046625,molecular_function sphingolipid binding;GO:0046872,molecular_function metal ion binding;GO:0050870,biological_process positive regulation of T cell activation;GO:0051023,biological_process regulation of immunoglobulin secretion;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051291,biological_process protein heterooligomerization;GO:0051865,biological_process protein autoubiquitination;GO:0060544,biological_process regulation of necroptotic process;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070207,biological_process protein homotrimerization;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0071550,biological_process death-inducing signaling complex assembly;GO:0071732,biological_process cellular response to nitric oxide;GO:0090073,biological_process positive regulation of protein homodimerization activity;GO:0097057,cellular_component TRAF2-GSTP1 complex;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097300,biological_process programmed necrotic cell death;GO:1901215,biological_process negative regulation of neuron death;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903265,biological_process positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1903721,biological_process positive regulation of I-kappaB phosphorylation;GO:1990597,cellular_component AIP1-IRE1 complex;GO:1990604,cellular_component IRE1-TRAF2-ASK1 complex;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]; K03173	TNF receptor associated factor 2 [Source:HGNC Symbol%3BAcc:HGNC:12032]
ENSG00000126581	53.21	55.94	56.04	57.45	57.34	57.52	-0.050070192690698	6.4183853018461	0.435053527934072	0.785958294607136	17:42810133-42833350:-	BECN1	75;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0000423,biological_process macromitophagy;GO:0000910,biological_process cytokinesis;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006968,biological_process cellular defense response;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0007040,biological_process lysosome organization;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007568,biological_process aging;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010008,cellular_component endosome membrane;GO:0010040,biological_process response to iron(II) ion;GO:0010288,biological_process response to lead ion;GO:0010508,biological_process positive regulation of autophagy;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016236,biological_process macroautophagy;GO:0016579,biological_process protein deubiquitination;GO:0019898,cellular_component extrinsic component of membrane;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031667,biological_process response to nutrient levels;GO:0031966,cellular_component mitochondrial membrane;GO:0032465,biological_process regulation of cytokinesis;GO:0032801,biological_process receptor catabolic process;GO:0033197,biological_process response to vitamin E;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034271,cellular_component phosphatidylinositol 3-kinase complex, class III, type I;GO:0034272,cellular_component phosphatidylinositol 3-kinase complex, class III, type II;GO:0035032,cellular_component phosphatidylinositol 3-kinase complex, class III;GO:0042149,biological_process cellular response to glucose starvation;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043652,biological_process engulfment of apoptotic cell;GO:0044804,biological_process nucleophagy;GO:0045324,biological_process late endosome to vacuole transport;GO:0045335,cellular_component phagocytic vesicle;GO:0048666,biological_process neuron development;GO:0050435,biological_process beta-amyloid metabolic process;GO:0050790,biological_process regulation of catalytic activity;GO:0051020,molecular_function GTPase binding;GO:0051301,biological_process cell division;GO:0051607,biological_process defense response to virus;GO:0051707,biological_process response to other organism;GO:0060548,biological_process negative regulation of cell death;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071275,biological_process cellular response to aluminum ion;GO:0071280,biological_process cellular response to copper ion;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0098780,biological_process response to mitochondrial depolarisation;GO:1902425,biological_process positive regulation of attachment of mitotic spindle microtubules to kinetochore;GO:1905672,biological_process negative regulation of lysosome organization;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2000786,biological_process positive regulation of autophagosome assembly	BECN, VPS30, ATG6; beclin; K08334	beclin 1 [Source:HGNC Symbol%3BAcc:HGNC:1034]
ENSG00000175048	3.57	3.07	3.22	3.22	4.46	3.31	-0.136060106365138	2.39361091594826	0.435186303699495	0.786083758414119	6:157381132-157678146:+	ZDHHC14	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	ZDHHC9_14_18; palmitoyltransferase ZDHHC9/14/18 [EC:2.3.1.225]; K16675	zinc finger DHHC-type containing 14 [Source:HGNC Symbol%3BAcc:HGNC:20341]
ENSG00000110066	13.92	12.27	16.11	14.57	15.11	15.18	-0.0675202575937915	5.39712502732707	0.435313276717181	0.786138808658547	11:68154862-68213828:-	KMT5B	15;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007517,biological_process muscle organ development;GO:0008168,molecular_function methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034773,biological_process histone H4-K20 trimethylation;GO:0042799,molecular_function histone methyltransferase activity (H4-K20 specific)	SUV420H; [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362]; K11429	lysine methyltransferase 5B [Source:HGNC Symbol%3BAcc:HGNC:24283]
ENSG00000108592	29.05	30.70	27.85	28.22	29.96	26.77	0.0544453192369027	6.21984951225029	0.435343444027943	0.786138808658547	17:63819432-63830012:-	FTSJ3	17;GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466,biological_process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001510,biological_process RNA methylation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008649,molecular_function rRNA methyltransferase activity;GO:0008650,molecular_function rRNA (uridine-2'-O-)-methyltransferase activity;GO:0016435,molecular_function rRNA (guanine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0042254,biological_process ribosome biogenesis	NA	FtsJ homolog 3 [Source:HGNC Symbol%3BAcc:HGNC:17136]
ENSG00000139637	21.29	20.59	21.47	20.31	20.37	20.45	0.0650359927427291	4.55899615605742	0.435453287327967	0.786222786269389	12:53299685-53307177:+	C12orf10	7;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0035641,biological_process locomotory exploration behavior;GO:0043473,biological_process pigmentation;GO:0070062,cellular_component extracellular exosome	NA	chromosome 12 open reading frame 10 [Source:HGNC Symbol%3BAcc:HGNC:17590]
ENSG00000033800	10.08	10.21	9.64	8.41	10.42	9.76	0.0765161011023706	4.31851979223553	0.435739579765075	0.786625276850476	15:68054178-68198603:+	PIAS1	37;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007259,biological_process JAK-STAT cascade;GO:0007283,biological_process spermatogenesis;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008542,biological_process visual learning;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0042127,biological_process regulation of cell proliferation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045444,biological_process fat cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0051152,biological_process positive regulation of smooth muscle cell differentiation;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0061665,molecular_function SUMO ligase activity;GO:0065004,biological_process protein-DNA complex assembly	PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]; K04706	protein inhibitor of activated STAT 1 [Source:HGNC Symbol%3BAcc:HGNC:2752]
ENSG00000198837	12.50	11.48	12.62	12.24	11.76	11.59	0.0554360427315289	5.77102178568567	0.435910254237646	0.786818959699274	1:153929500-153946696:-	DENND4B	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0032483,biological_process regulation of Rab protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	DENN domain containing 4B [Source:HGNC Symbol%3BAcc:HGNC:29044]
ENSG00000137563	149.40	163.68	144.66	149.19	149.46	146.16	0.0514971098540051	7.16664496497911	0.436042173001957	0.78683407214022	8:63015078-63039171:-	GGH	22;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005764,cellular_component lysosome;GO:0005773,cellular_component vacuole;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008238,molecular_function exopeptidase activity;GO:0008242,molecular_function omega peptidase activity;GO:0010043,biological_process response to zinc ion;GO:0016787,molecular_function hydrolase activity;GO:0032868,biological_process response to insulin;GO:0034722,molecular_function gamma-glutamyl-peptidase activity;GO:0035578,cellular_component azurophil granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0042470,cellular_component melanosome;GO:0042493,biological_process response to drug;GO:0043312,biological_process neutrophil degranulation;GO:0045471,biological_process response to ethanol;GO:0046900,biological_process tetrahydrofolylpolyglutamate metabolic process;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen	GGH; gamma-glutamyl hydrolase [EC:3.4.19.9]; K01307	gamma-glutamyl hydrolase [Source:HGNC Symbol%3BAcc:HGNC:4248]
ENSG00000162664	25.61	27.49	27.91	24.61	28.34	25.38	0.0593985095060262	5.5841608241107	0.436143902511902	0.78683407214022	1:89995111-90035531:+	ZNF326	17;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016363,cellular_component nuclear matrix;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043484,biological_process regulation of RNA splicing;GO:0044609,cellular_component DBIRD complex;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 326 [Source:HGNC Symbol%3BAcc:HGNC:14104]
ENSG00000131711	9.37	9.48	9.85	9.93	9.78	10.24	-0.0495778248827876	6.19606034346016	0.436149688346958	0.78683407214022	5:72107233-72209570:+	MAP1B	26;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001578,biological_process microtubule bundle formation;GO:0001750,cellular_component photoreceptor outer segment;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0008017,molecular_function microtubule binding;GO:0009987,biological_process cellular process;GO:0014069,cellular_component postsynaptic density;GO:0016358,biological_process dendrite development;GO:0030054,cellular_component cell junction;GO:0032387,biological_process negative regulation of intracellular transport;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0045202,cellular_component synapse;GO:0045773,biological_process positive regulation of axon extension;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0048675,biological_process axon extension;GO:0061162,biological_process establishment of monopolar cell polarity	NA	microtubule associated protein 1B [Source:HGNC Symbol%3BAcc:HGNC:6836]
ENSG00000198932	1.06	0.71	0.56	0.89	0.69	1.14	-0.206519942458266	1.89475841010802	0.436172178393366	0.78683407214022	X:102651365-102659083:+	GPRASP1	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008333,biological_process endosome to lysosome transport;GO:1990172,biological_process G-protein coupled receptor catabolic process	NA	G protein-coupled receptor associated sorting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24834]
ENSG00000180901	14.77	15.62	15.30	16.04	17.21	15.60	-0.0861331825385891	3.65338720708802	0.436301336434672	0.786834873211059	17:75032574-75065889:+	KCTD2	5;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032403,molecular_function protein complex binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051260,biological_process protein homooligomerization;GO:0097602,molecular_function cullin family protein binding	NA	potassium channel tetramerization domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:21294]
ENSG00000198668	229.03	253.36	215.28	228.75	264.70	239.98	-0.0621272562656784	6.75744012035012	0.436307351979313	0.786834873211059	14:90396501-90408261:+	CALM1	20;GO:0000922,cellular_component spindle pole;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0014069,cellular_component postsynaptic density;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0043209,cellular_component myelin sheath;GO:0044325,molecular_function ion channel binding;GO:0046872,molecular_function metal ion binding;GO:0060315,biological_process negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0090150,biological_process establishment of protein localization to membrane;GO:0090151,biological_process establishment of protein localization to mitochondrial membrane;GO:1900242,biological_process regulation of synaptic vesicle endocytosis;GO:2000300,biological_process regulation of synaptic vesicle exocytosis	CALM; calmodulin; K02183	calmodulin 1 [Source:HGNC Symbol%3BAcc:HGNC:1442]
ENSG00000198356	93.56	101.24	91.86	92.30	94.00	92.34	0.0507047490469299	6.62224812435032	0.436362786367915	0.786834873211059	19:12737138-12748323:+	ASNA1	19;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0015105,molecular_function arsenite transmembrane transporter activity;GO:0015698,biological_process inorganic anion transport;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043492,molecular_function ATPase activity, coupled to movement of substances;GO:0045048,biological_process protein insertion into ER membrane;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	arsA arsenite transporter%2C ATP-binding%2C homolog 1 (bacterial) [Source:HGNC Symbol%3BAcc:HGNC:752]
ENSG00000172939	26.89	27.34	29.36	29.64	29.38	28.52	-0.0538328145418707	5.56860808618677	0.436496846639957	0.786862460348546	3:38165088-38255488:+	OXSR1	29;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006979,biological_process response to oxidative stress;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071476,biological_process cellular hypotonic response;GO:1901017,biological_process negative regulation of potassium ion transmembrane transporter activity;GO:1901380,biological_process negative regulation of potassium ion transmembrane transport;GO:2000681,biological_process negative regulation of rubidium ion transport;GO:2000687,biological_process negative regulation of rubidium ion transmembrane transporter activity	NA	oxidative stress responsive 1 [Source:HGNC Symbol%3BAcc:HGNC:8508]
ENSG00000095059	50.34	48.62	46.67	52.39	48.26	51.57	-0.052332388096764	6.02657833272074	0.436504866024336	0.786862460348546	19:12675716-12681902:-	DHPS	14;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0008216,biological_process spermidine metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008612,biological_process peptidyl-lysine modification to peptidyl-hypusine;GO:0016740,molecular_function transferase activity;GO:0034038,molecular_function deoxyhypusine synthase activity;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0046203,biological_process spermidine catabolic process;GO:0051289,biological_process protein homotetramerization	NA	deoxyhypusine synthase [Source:HGNC Symbol%3BAcc:HGNC:2869]
ENSG00000186567	16.17	16.99	15.87	16.06	16.52	13.99	0.0846448815792661	3.85417633736306	0.436570657817009	0.786866788947659	19:44662277-44684359:+	CEACAM19	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	carcinoembryonic antigen related cell adhesion molecule 19 [Source:HGNC Symbol%3BAcc:HGNC:31951]
ENSG00000151773	4.82	5.09	6.30	6.93	6.23	5.05	-0.1491080011868	2.35543075058656	0.436638190687063	0.786874253919645	13:43823908-43879727:-	CCDC122	NA	NA	coiled-coil domain containing 122 [Source:HGNC Symbol%3BAcc:HGNC:26478]
ENSG00000121390	17.25	17.11	19.67	18.24	20.83	18.18	-0.068736234452788	4.90873113531024	0.436850584356612	0.787142735319875	13:19674751-19783019:-	PSPC1	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0042382,cellular_component paraspeckles;GO:0042752,biological_process regulation of circadian rhythm;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process	NA	paraspeckle component 1 [Source:HGNC Symbol%3BAcc:HGNC:20320]
ENSG00000040633	45.63	56.05	51.70	51.65	56.24	53.36	-0.0640356508902546	6.06781374351611	0.436930429124645	0.787172339147202	17:7235027-7239722:-	PHF23	11;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006914,biological_process autophagy;GO:0007076,biological_process mitotic chromosome condensation;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0046872,molecular_function metal ion binding;GO:1901097,biological_process negative regulation of autophagosome maturation;GO:1902902,biological_process negative regulation of autophagosome assembly	NA	PHD finger protein 23 [Source:HGNC Symbol%3BAcc:HGNC:28428]
ENSG00000154928	14.76	15.47	14.60	15.65	16.87	14.56	-0.0599086837351881	5.52203819263873	0.43726517578274	0.787573832689891	3:134597800-135260467:+	EPHB1	58;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001771,biological_process immunological synapse formation;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005003,molecular_function ephrin receptor activity;GO:0005005,molecular_function transmembrane-ephrin receptor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0008046,molecular_function axon guidance receptor activity;GO:0014719,biological_process skeletal muscle satellite cell activation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0021545,biological_process cranial nerve development;GO:0021631,biological_process optic nerve morphogenesis;GO:0021952,biological_process central nervous system projection neuron axonogenesis;GO:0022008,biological_process neurogenesis;GO:0030010,biological_process establishment of cell polarity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0031589,biological_process cell-substrate adhesion;GO:0031901,cellular_component early endosome membrane;GO:0032403,molecular_function protein complex binding;GO:0032433,cellular_component filopodium tip;GO:0042995,cellular_component cell projection;GO:0045121,cellular_component membrane raft;GO:0046328,biological_process regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain;GO:0051965,biological_process positive regulation of synapse assembly;GO:0060326,biological_process cell chemotaxis;GO:0060996,biological_process dendritic spine development;GO:0060997,biological_process dendritic spine morphogenesis;GO:0061351,biological_process neural precursor cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:1901214,biological_process regulation of neuron death;GO:1902723,biological_process negative regulation of skeletal muscle satellite cell proliferation;GO:1902725,biological_process negative regulation of satellite cell differentiation	EPHB1, ELK, NET; Eph receptor B1 [EC:2.7.10.1]; K05110	EPH receptor B1 [Source:HGNC Symbol%3BAcc:HGNC:3392]
ENSG00000112062	38.46	34.67	32.96	35.29	36.96	39.42	-0.0612250761881695	5.43747258545797	0.437314036172904	0.787573832689891	6:36027676-36111236:+	MAPK14	92;GO:0000077,biological_process DNA damage checkpoint;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0000902,biological_process cell morphogenesis;GO:0000922,cellular_component spindle pole;GO:0001502,biological_process cartilage condensation;GO:0001525,biological_process angiogenesis;GO:0001890,biological_process placenta development;GO:0002062,biological_process chondrocyte differentiation;GO:0002741,biological_process positive regulation of cytokine secretion involved in immune response;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006006,biological_process glucose metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006928,biological_process movement of cell or subcellular component;GO:0006935,biological_process chemotaxis;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007519,biological_process skeletal muscle tissue development;GO:0010628,biological_process positive regulation of gene expression;GO:0010759,biological_process positive regulation of macrophage chemotaxis;GO:0010831,biological_process positive regulation of myotube differentiation;GO:0014835,biological_process myoblast differentiation involved in skeletal muscle regeneration;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019395,biological_process fatty acid oxidation;GO:0019899,molecular_function enzyme binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030278,biological_process regulation of ossification;GO:0030316,biological_process osteoclast differentiation;GO:0031281,biological_process positive regulation of cyclase activity;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032495,biological_process response to muramyl dipeptide;GO:0032496,biological_process response to lipopolysaccharide;GO:0034774,cellular_component secretory granule lumen;GO:0035556,biological_process intracellular signal transduction;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0035994,biological_process response to muscle stretch;GO:0038066,biological_process p38MAPK cascade;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0043312,biological_process neutrophil degranulation;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046326,biological_process positive regulation of glucose import;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048273,molecular_function mitogen-activated protein kinase p38 binding;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051146,biological_process striated muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051525,molecular_function NFAT protein binding;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071223,biological_process cellular response to lipoteichoic acid;GO:0071479,biological_process cellular response to ionizing radiation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090336,biological_process positive regulation of brown fat cell differentiation;GO:0090400,biological_process stress-induced premature senescence;GO:0098586,biological_process cellular response to virus;GO:1900015,biological_process regulation of cytokine production involved in inflammatory response;GO:1901741,biological_process positive regulation of myoblast fusion;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1905050,biological_process positive regulation of metallopeptidase activity;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2001184,biological_process positive regulation of interleukin-12 secretion	P38; p38 MAP kinase [EC:2.7.11.24]; K04441	mitogen-activated protein kinase 14 [Source:HGNC Symbol%3BAcc:HGNC:6876]
ENSG00000164610	17.33	15.95	18.27	17.12	16.49	22.29	-0.102935182209232	3.69833762922884	0.437399083270764	0.787573832689891	7:33094796-33109401:-	RP9	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005785,cellular_component signal recognition particle receptor complex;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0046872,molecular_function metal ion binding;GO:0050890,biological_process cognition	NA	retinitis pigmentosa 9 (autosomal dominant) [Source:HGNC Symbol%3BAcc:HGNC:10288]
ENSG00000078699	9.48	9.08	11.04	9.55	9.27	9.54	0.0783464148305246	4.35165079950791	0.437483866443905	0.787573832689891	20:33490074-33650036:+	CBFA2T2	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010976,biological_process positive regulation of neuron projection development;GO:0010977,biological_process negative regulation of neuron projection development;GO:0030855,biological_process epithelial cell differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0060575,biological_process intestinal epithelial cell differentiation	NA	CBFA2/RUNX1 translocation partner 2 [Source:HGNC Symbol%3BAcc:HGNC:1536]
ENSG00000107902	14.18	16.86	14.59	14.12	15.87	12.92	0.0936132057943602	3.61202912900118	0.43761274830003	0.787573832689891	10:124461833-124617888:+	LHPP	15;GO:0000287,molecular_function magnesium ion binding;GO:0004427,molecular_function inorganic diphosphatase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0008969,molecular_function phosphohistidine phosphatase activity;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016311,biological_process dephosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding	LHPP; phospholysine phosphohistidine inorganic pyrophosphate phosphatase [EC:3.6.1.1 3.1.3.-]; K11725	phospholysine phosphohistidine inorganic pyrophosphate phosphatase [Source:HGNC Symbol%3BAcc:HGNC:30042]
ENSG00000183955	21.78	18.85	18.89	21.60	18.94	22.77	-0.0749620016026391	4.58435036730483	0.437659298690173	0.787573832689891	12:123383772-123409358:+	KMT5A	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002039,molecular_function p53 binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008168,molecular_function methyltransferase activity;GO:0016278,molecular_function lysine N-methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0032259,biological_process methylation;GO:0034770,biological_process histone H4-K20 methylation;GO:0034968,biological_process histone lysine methylation;GO:0042799,molecular_function histone methyltransferase activity (H4-K20 specific);GO:0043516,biological_process regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051301,biological_process cell division;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	SETD8; [histone H4]-lysine20 N-methyltransferase SETD8 [EC:2.1.1.361]; K11428	lysine methyltransferase 5A [Source:HGNC Symbol%3BAcc:HGNC:29489]
ENSG00000148841	6.20	5.42	5.83	5.70	4.81	5.91	0.103122755902755	3.23907384860983	0.43773415220305	0.787573832689891	10:104309697-104338404:-	ITPRIP	2;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	inositol 1%2C4%2C5-trisphosphate receptor interacting protein [Source:HGNC Symbol%3BAcc:HGNC:29370]
ENSG00000172824	3.53	3.39	5.93	4.18	3.54	3.89	0.164388842568386	2.96021287132629	0.437753864060115	0.787573832689891	16:66988588-67009758:+	CES4A	3;GO:0005576,cellular_component extracellular region;GO:0016787,molecular_function hydrolase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity	NA	carboxylesterase 4A [Source:HGNC Symbol%3BAcc:HGNC:26741]
ENSG00000105576	33.12	33.66	34.05	34.21	34.73	36.24	-0.0496190722204412	6.60013996949371	0.437841963006283	0.787573832689891	19:12699193-12724011:-	TNPO2	15;GO:0000060,biological_process protein import into nucleus, translocation;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery	NA	transportin 2 [Source:HGNC Symbol%3BAcc:HGNC:19998]
ENSG00000146834	30.68	31.21	31.69	30.83	31.96	28.07	0.0550101624847206	5.99335314575646	0.437985058749255	0.787573832689891	7:100428789-100434126:+	MEPCE	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001510,biological_process RNA methylation;GO:0003723,molecular_function RNA binding;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016073,biological_process snRNA metabolic process;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0035562,biological_process negative regulation of chromatin binding;GO:0040031,biological_process snRNA modification;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle	NA	methylphosphate capping enzyme [Source:HGNC Symbol%3BAcc:HGNC:20247]
ENSG00000188994	10.67	10.36	10.44	9.80	10.66	10.19	0.0504220227432413	6.43036260947637	0.437986627789395	0.787573832689891	6:87152832-87264196:+	ZNF292	9;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 292 [Source:HGNC Symbol%3BAcc:HGNC:18410]
ENSG00000136699	21.66	24.83	23.70	23.62	27.28	23.00	-0.0642552443716993	6.04087689104584	0.438125922661064	0.787573832689891	2:130151391-130182750:-	SMPD4	16;GO:0000139,cellular_component Golgi membrane;GO:0004767,molecular_function sphingomyelin phosphodiesterase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006685,biological_process sphingomyelin catabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0046513,biological_process ceramide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0050290,molecular_function sphingomyelin phosphodiesterase D activity;GO:0071356,biological_process cellular response to tumor necrosis factor	SMPD4; sphingomyelin phosphodiesterase 4 [EC:3.1.4.12]; K12353	sphingomyelin phosphodiesterase 4 [Source:HGNC Symbol%3BAcc:HGNC:32949]
ENSG00000121577	0.56	0.91	0.88	0.95	1.27	0.73	-0.324852775982254	0.327099775976434	0.438140289905028	0.787573832689891	3:119636456-119665324:-	POPDC2	7;GO:0002027,biological_process regulation of heart rate;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042383,cellular_component sarcolemma	NA	popeye domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:17648]
ENSG00000104472	59.74	52.50	56.87	57.71	63.85	57.26	-0.0628717654092336	4.88546301133564	0.438151794311437	0.787573832689891	8:140511297-140517137:+	CHRAC1	11;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006338,biological_process chromatin remodeling;GO:0008622,cellular_component epsilon DNA polymerase complex;GO:0008623,cellular_component CHRAC;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0071897,biological_process DNA biosynthetic process	NA	chromatin accessibility complex 1 [Source:HGNC Symbol%3BAcc:HGNC:13544]
ENSG00000161914	1.56	1.81	1.53	1.69	1.33	1.36	0.161396417564753	1.80168058129535	0.438162409023727	0.787573832689891	19:11483426-11505923:-	ZNF653	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 653 [Source:HGNC Symbol%3BAcc:HGNC:25196]
ENSG00000124789	19.88	19.12	20.00	20.62	20.88	20.09	-0.0487722467833977	6.50861517539664	0.438168443450929	0.787573832689891	6:17615034-17706834:-	NUP153	37;GO:0003677,molecular_function DNA binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008139,molecular_function nuclear localization sequence binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0042405,cellular_component nuclear inclusion body;GO:0042802,molecular_function identical protein binding;GO:0043495,molecular_function protein anchor;GO:0043657,cellular_component host cell;GO:0044615,cellular_component nuclear pore nuclear basket;GO:0046718,biological_process viral entry into host cell;GO:0046832,biological_process negative regulation of RNA export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0051028,biological_process mRNA transport;GO:0051292,biological_process nuclear pore complex assembly;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075732,biological_process viral penetration into host nucleus;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP153; nuclear pore complex protein Nup153; K14296	nucleoporin 153 [Source:HGNC Symbol%3BAcc:HGNC:8062]
ENSG00000152767	17.73	19.02	17.43	17.67	20.40	18.71	-0.0570294824623216	6.46346196508354	0.438247544727676	0.787601965065099	13:98142561-98455176:+	FARP1	24;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007416,biological_process synapse assembly;GO:0008092,molecular_function cytoskeletal protein binding;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030425,cellular_component dendrite;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0048365,molecular_function Rac GTPase binding;GO:0048813,biological_process dendrite morphogenesis	NA	FERM%2C ARH/RhoGEF and pleckstrin domain protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3591]
ENSG00000132581	49.35	54.21	50.19	48.88	50.10	49.57	0.0568271253700703	5.04761070118596	0.438601857298792	0.788124617059917	17:28648355-28662189:-	SDF2	8;GO:0004169,molecular_function dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0016020,cellular_component membrane;GO:0035269,biological_process protein O-linked mannosylation;GO:0071712,biological_process ER-associated misfolded protein catabolic process	NA	stromal cell derived factor 2 [Source:HGNC Symbol%3BAcc:HGNC:10675]
ENSG00000112130	13.95	15.09	13.70	16.22	14.52	14.39	-0.0714633726681632	4.61689989108824	0.438704455824379	0.788194877717184	6:37353971-37394738:+	RNF8	41;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000781,cellular_component chromosome, telomeric region;GO:0003682,molecular_function chromatin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007286,biological_process spermatid development;GO:0008270,molecular_function zinc ion binding;GO:0010212,biological_process response to ionizing radiation;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0030496,cellular_component midbody;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033522,biological_process histone H2A ubiquitination;GO:0033523,biological_process histone H2B ubiquitination;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0035093,biological_process spermatogenesis, exchange of chromosomal proteins;GO:0035861,cellular_component site of double-strand break;GO:0036297,biological_process interstrand cross-link repair;GO:0042393,molecular_function histone binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043486,biological_process histone exchange;GO:0045190,biological_process isotype switching;GO:0045739,biological_process positive regulation of DNA repair;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0051865,biological_process protein autoubiquitination;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070535,biological_process histone H2A K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination	NA	ring finger protein 8 [Source:HGNC Symbol%3BAcc:HGNC:10071]
ENSG00000186642	0.85	0.41	0.74	0.88	0.52	0.97	-0.213176426386903	1.55850869106997	0.438779623077263	0.788215840992485	11:72576140-72674591:-	PDE2A	49;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0004112,molecular_function cyclic-nucleotide phosphodiesterase activity;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118,molecular_function cGMP-stimulated cyclic-nucleotide phosphodiesterase activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006198,biological_process cAMP catabolic process;GO:0006626,biological_process protein targeting to mitochondrion;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008144,molecular_function drug binding;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019933,biological_process cAMP-mediated signaling;GO:0019934,biological_process cGMP-mediated signaling;GO:0030552,molecular_function cAMP binding;GO:0030553,molecular_function cGMP binding;GO:0030818,biological_process negative regulation of cAMP biosynthetic process;GO:0030911,molecular_function TPR domain binding;GO:0033159,biological_process negative regulation of protein import into nucleus, translocation;GO:0035690,biological_process cellular response to drug;GO:0036006,biological_process cellular response to macrophage colony-stimulating factor stimulus;GO:0042734,cellular_component presynaptic membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043116,biological_process negative regulation of vascular permeability;GO:0043117,biological_process positive regulation of vascular permeability;GO:0046069,biological_process cGMP catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047555,molecular_function 3',5'-cyclic-GMP phosphodiesterase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050729,biological_process positive regulation of inflammatory response;GO:0061028,biological_process establishment of endothelial barrier;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071321,biological_process cellular response to cGMP;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus	cpdP; 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]; K01120	phosphodiesterase 2A [Source:HGNC Symbol%3BAcc:HGNC:8777]
ENSG00000198074	163.38	200.61	156.60	147.22	192.73	155.47	0.0823095663458276	7.32738380213174	0.439007606863675	0.788480905104235	7:134527591-134541408:+	AKR1B10	18;GO:0001523,biological_process retinoid metabolic process;GO:0001758,molecular_function retinal dehydrogenase activity;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0007586,biological_process digestion;GO:0008202,biological_process steroid metabolic process;GO:0016488,biological_process farnesol catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0044597,biological_process daunorubicin metabolic process;GO:0044598,biological_process doxorubicin metabolic process;GO:0045550,molecular_function geranylgeranyl reductase activity;GO:0047718,molecular_function indanol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	AKR1B; aldehyde reductase [EC:1.1.1.21]; K00011	aldo-keto reductase family 1 member B10 [Source:HGNC Symbol%3BAcc:HGNC:382]
ENSG00000158636	4.96	5.44	5.10	4.39	5.11	5.31	0.0723175487666666	4.39667200826998	0.439054218648229	0.788480905104235	11:76444922-76553025:+	EMSY	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016569,biological_process covalent chromatin modification;GO:0042803,molecular_function protein homodimerization activity	NA	EMSY%2C BRCA2 interacting transcriptional repressor [Source:HGNC Symbol%3BAcc:HGNC:18071]
ENSG00000107864	0.73	0.54	0.56	0.53	0.50	0.50	0.284564762174449	0.424961845471995	0.439217329899986	0.788484307983569	10:92046691-92291087:-	CPEB3	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0007616,biological_process long-term memory;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030014,cellular_component CCR4-NOT complex;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0035613,molecular_function RNA stem-loop binding;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043022,molecular_function ribosome binding;GO:0045182,molecular_function translation regulator activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045727,biological_process positive regulation of translation;GO:0048167,biological_process regulation of synaptic plasticity;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060998,biological_process regulation of dendritic spine development;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0097440,cellular_component apical dendrite;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1900248,biological_process negative regulation of cytoplasmic translational elongation;GO:1900365,biological_process positive regulation of mRNA polyadenylation;GO:1990124,cellular_component messenger ribonucleoprotein complex;GO:2000766,biological_process negative regulation of cytoplasmic translation	NA	cytoplasmic polyadenylation element binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:21746]
ENSG00000168065	5.39	6.14	4.42	5.04	6.16	6.18	-0.123356610788649	3.21612636723578	0.439226820246452	0.788484307983569	11:64555625-64572875:+	SLC22A11	22;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0009897,cellular_component external side of plasma membrane;GO:0015143,molecular_function urate transmembrane transporter activity;GO:0015347,molecular_function sodium-independent organic anion transmembrane transporter activity;GO:0015698,biological_process inorganic anion transport;GO:0015711,biological_process organic anion transport;GO:0015747,biological_process urate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0043252,biological_process sodium-independent organic anion transport;GO:0046415,biological_process urate metabolic process;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1903825,biological_process organic acid transmembrane transport	NA	solute carrier family 22 member 11 [Source:HGNC Symbol%3BAcc:HGNC:18120]
ENSG00000267673	10.51	7.19	4.75	9.53	8.70	7.69	-0.189044622897784	2.22367239797363	0.439246676041761	0.788484307983569	19:10310044-10316015:-	FDX2	11;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0009055,molecular_function electron carrier activity;GO:0016125,biological_process sterol metabolic process;GO:0044281,biological_process small molecule metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process	NA	ferredoxin 2 [Source:HGNC Symbol%3BAcc:HGNC:30546]
ENSG00000166407	9.08	6.44	7.66	6.88	6.19	7.89	0.170527443321006	1.9198561142763	0.439446114071337	0.788577922093597	11:8224303-8268716:-	LMO1	8;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046013,biological_process regulation of T cell homeostatic proliferation;GO:0046872,molecular_function metal ion binding;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	NA	LIM domain only 1 [Source:HGNC Symbol%3BAcc:HGNC:6641]
ENSG00000157483	85.08	87.64	83.78	82.82	84.48	83.34	0.044755141341775	8.20362502403768	0.439525069111757	0.788577922093597	15:59132433-59372900:-	MYO1E	35;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0001570,biological_process vasculogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0003094,biological_process glomerular filtration;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005903,cellular_component brush border;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0006807,biological_process nitrogen compound metabolic process;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0015629,cellular_component actin cytoskeleton;GO:0016459,cellular_component myosin complex;GO:0030048,biological_process actin filament-based movement;GO:0030054,cellular_component cell junction;GO:0030097,biological_process hemopoiesis;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032836,biological_process glomerular basement membrane development;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035166,biological_process post-embryonic hemopoiesis;GO:0042623,molecular_function ATPase activity, coupled;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome;GO:0072015,biological_process glomerular visceral epithelial cell development	MYO1; myosin I; K10356	myosin IE [Source:HGNC Symbol%3BAcc:HGNC:7599]
ENSG00000141279	68.38	67.64	70.15	67.34	67.65	66.43	0.0456250272320813	7.78451494509911	0.43961576435458	0.788577922093597	17:47522941-47623276:+	NPEPPS	17;GO:0000209,biological_process protein polyubiquitination;GO:0004177,molecular_function aminopeptidase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	aminopeptidase puromycin sensitive [Source:HGNC Symbol%3BAcc:HGNC:7900]
ENSG00000175029	27.75	26.99	28.54	29.93	27.37	29.76	-0.0514475698638561	6.54270023473381	0.439633422563421	0.788577922093597	10:124984316-125161170:-	CTBP2	33;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008152,biological_process metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016032,biological_process viral process;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016618,molecular_function hydroxypyruvate reductase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019079,biological_process viral genome replication;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030267,molecular_function glyoxylate reductase (NADP) activity;GO:0032403,molecular_function protein complex binding;GO:0035563,biological_process positive regulation of chromatin binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042974,molecular_function retinoic acid receptor binding;GO:0045202,cellular_component synapse;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048386,biological_process positive regulation of retinoic acid receptor signaling pathway;GO:0050872,biological_process white fat cell differentiation;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0097470,cellular_component ribbon synapse;GO:1990830,biological_process cellular response to leukemia inhibitory factor	CTBP; C-terminal binding protein; K04496	C-terminal binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:2495]
ENSG00000119878	55.01	69.39	39.84	55.85	62.08	61.27	-0.123613421965722	4.12175049231148	0.439646248004541	0.788577922093597	2:46616415-46625742:+	CRIPT	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0008017,molecular_function microtubule binding;GO:0014069,cellular_component postsynaptic density;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030425,cellular_component dendrite;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0032403,molecular_function protein complex binding;GO:0035372,biological_process protein localization to microtubule;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0045184,biological_process establishment of protein localization;GO:0045202,cellular_component synapse;GO:0097110,molecular_function scaffold protein binding;GO:1902897,biological_process regulation of postsynaptic density protein 95 clustering	NA	CXXC repeat containing interactor of PDZ3 domain [Source:HGNC Symbol%3BAcc:HGNC:14312]
ENSG00000162512	12.29	17.10	11.81	11.54	15.30	11.34	0.114504154678068	4.22016788097348	0.439679996681687	0.788577922093597	1:30869466-30908761:-	SDC3	12;GO:0001523,biological_process retinoid metabolic process;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0050900,biological_process leukocyte migration	SDC3; syndecan 3; K16337	syndecan 3 [Source:HGNC Symbol%3BAcc:HGNC:10660]
ENSG00000138172	0.95	1.38	0.68	1.24	0.86	1.60	-0.326451640749762	0.29735936471893	0.439798495737011	0.788676499217497	10:103446785-103452402:-	CALHM2	8;GO:0005261,molecular_function cation channel activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	calcium homeostasis modulator 2 [Source:HGNC Symbol%3BAcc:HGNC:23493]
ENSG00000117643	0.82	0.25	0.97	0.55	0.52	0.63	0.321690251469356	0.450595624847212	0.439997064135854	0.78874153747627	1:25617467-25786207:+	MAN1C1	17;GO:0000139,cellular_component Golgi membrane;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006491,biological_process N-glycan processing;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030173,cellular_component integral component of Golgi membrane;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1904381,biological_process Golgi apparatus mannose trimming	MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]; K01230	mannosidase alpha class 1C member 1 [Source:HGNC Symbol%3BAcc:HGNC:19080]
ENSG00000237489	3.39	2.29	2.36	2.40	3.44	4.13	-0.281531326485752	0.368852761170672	0.440005417989721	0.78874153747627	10:130063899-130110817:-	LINC00959	NA	NA	long intergenic non-protein coding RNA 959 [Source:HGNC Symbol%3BAcc:HGNC:48677]
ENSG00000138798	1.62	2.43	2.07	1.84	2.16	1.57	0.136343489229064	2.83568430825369	0.440134499507827	0.78874153747627	4:109912883-110012266:+	EGF	67;GO:0000165,biological_process MAPK cascade;GO:0000186,biological_process activation of MAPKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0001525,biological_process angiogenesis;GO:0002092,biological_process positive regulation of receptor internalization;GO:0002576,biological_process platelet degranulation;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006260,biological_process DNA replication;GO:0007165,biological_process signal transduction;GO:0007171,biological_process activation of transmembrane receptor protein tyrosine kinase activity;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007262,biological_process STAT protein import into nucleus;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017147,molecular_function Wnt-protein binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021940,biological_process positive regulation of cerebellar granule cell precursor proliferation;GO:0030297,molecular_function transmembrane receptor protein tyrosine kinase activator activity;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031093,cellular_component platelet alpha granule lumen;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043235,cellular_component receptor complex;GO:0043388,biological_process positive regulation of DNA binding;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044332,biological_process Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0045741,biological_process positive regulation of epidermal growth factor-activated receptor activity;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051048,biological_process negative regulation of secretion;GO:0060059,biological_process embryonic retina morphogenesis in camera-type eye;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060749,biological_process mammary gland alveolus development;GO:0061024,biological_process membrane organization;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0090279,biological_process regulation of calcium ion import;GO:0090370,biological_process negative regulation of cholesterol efflux;GO:1900127,biological_process positive regulation of hyaluronan biosynthetic process;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:2000008,biological_process regulation of protein localization to cell surface;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000145,biological_process regulation of cell motility	EGF; epidermal growth factor; K04357	epidermal growth factor [Source:HGNC Symbol%3BAcc:HGNC:3229]
ENSG00000106804	3.78	3.35	3.69	3.68	3.64	4.20	-0.0740516674944791	4.24204779118776	0.440139736115794	0.78874153747627	9:120952334-121050276:-	C5	28;GO:0000187,biological_process activation of MAPK activity;GO:0001701,biological_process in utero embryonic development;GO:0002376,biological_process immune system process;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005579,cellular_component membrane attack complex;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0006950,biological_process response to stress;GO:0006954,biological_process inflammatory response;GO:0006956,biological_process complement activation;GO:0006957,biological_process complement activation, alternative pathway;GO:0006958,biological_process complement activation, classical pathway;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008009,molecular_function chemokine activity;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010760,biological_process negative regulation of macrophage chemotaxis;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0019835,biological_process cytolysis;GO:0030449,biological_process regulation of complement activation;GO:0045087,biological_process innate immune response;GO:0045766,biological_process positive regulation of angiogenesis;GO:0060326,biological_process cell chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:0090197,biological_process positive regulation of chemokine secretion	C5; complement component 5; K03994	complement C5 [Source:HGNC Symbol%3BAcc:HGNC:1331]
ENSG00000152256	9.68	7.66	7.19	7.42	8.35	7.23	0.111676091390275	3.46470003634886	0.440152471610257	0.78874153747627	2:172555372-172608669:+	PDK1	21;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004740,molecular_function pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005967,cellular_component mitochondrial pyruvate dehydrogenase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006468,biological_process protein phosphorylation;GO:0008283,biological_process cell proliferation;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0097411,biological_process hypoxia-inducible factor-1alpha signaling pathway	PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]; K12077	pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:8809]
ENSG00000186130	9.99	8.49	9.32	9.59	9.90	10.34	-0.0821591466143983	3.63452781566301	0.440601377677927	0.789311420126855	9:122908055-122913330:-	ZBTB6	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:16764]
ENSG00000173559	65.17	62.14	65.23	62.46	64.23	60.54	0.0546216358156683	5.50006101031517	0.44063855689213	0.789311420126855	2:191678067-191696659:+	NABP1	15;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0010212,biological_process response to ionizing radiation;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0070876,cellular_component SOSS complex	NA	nucleic acid binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26232]
ENSG00000164296	4.79	5.38	4.43	5.22	5.82	4.81	-0.115122720167818	3.01153058957491	0.440661253643688	0.789311420126855	5:149993117-150001167:-	TIGD6	3;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	tigger transposable element derived 6 [Source:HGNC Symbol%3BAcc:HGNC:18332]
ENSG00000057252	47.81	46.97	48.53	45.74	45.37	48.58	0.0489886309375833	6.28613244353761	0.440988050596471	0.789782812300388	1:179293713-179358680:+	SOAT1	23;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0004772,molecular_function sterol O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0010742,biological_process macrophage derived foam cell differentiation;GO:0010878,biological_process cholesterol storage;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0033344,biological_process cholesterol efflux;GO:0034379,biological_process very-low-density lipoprotein particle assembly;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0034435,biological_process cholesterol esterification;GO:0034736,molecular_function cholesterol O-acyltransferase activity;GO:0042632,biological_process cholesterol homeostasis;GO:0042986,biological_process positive regulation of amyloid precursor protein biosynthetic process	SOAT; sterol O-acyltransferase [EC:2.3.1.26]; K00637	sterol O-acyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:11177]
ENSG00000171863	1264.82	1242.20	1177.50	1320.74	1243.65	1271.25	-0.0463235871540353	9.63985466359943	0.441157104880272	0.789907114381633	2:3575204-3580919:+	RPS7	40;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008266,molecular_function poly(U) RNA binding;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019901,molecular_function protein kinase binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030686,cellular_component 90S preribosome;GO:0031012,cellular_component extracellular matrix;GO:0032040,cellular_component small-subunit processome;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0043234,cellular_component protein complex;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome;GO:1902255,biological_process positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:1904667,biological_process negative regulation of ubiquitin protein ligase activity;GO:1990948,molecular_function ubiquitin ligase inhibitor activity;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	RP-S7e, RPS7; small subunit ribosomal protein S7e; K02993	ribosomal protein S7 [Source:HGNC Symbol%3BAcc:HGNC:10440]
ENSG00000104611	7.22	7.33	10.56	9.25	8.35	9.89	-0.114202608552762	3.65028042359054	0.441184727624898	0.789907114381633	8:19313616-19396218:+	SH2D4A	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019902,molecular_function phosphatase binding	NA	SH2 domain containing 4A [Source:HGNC Symbol%3BAcc:HGNC:26102]
ENSG00000085831	14.62	14.02	15.21	16.11	15.73	14.32	-0.0588768866439201	5.14034060389263	0.441290057242528	0.789922884439889	1:51287257-51345116:-	TTC39A	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	tetratricopeptide repeat domain 39A [Source:HGNC Symbol%3BAcc:HGNC:18657]
ENSG00000152475	0.98	0.84	1.48	1.13	0.95	0.71	0.276085630907438	0.826363820035727	0.441396209944895	0.789922884439889	19:58367617-58381060:-	ZNF837	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 837 [Source:HGNC Symbol%3BAcc:HGNC:25164]
ENSG00000130396	32.39	30.07	33.33	32.83	31.32	36.17	-0.0540555125680207	7.57633439326564	0.441469234925799	0.789922884439889	6:167826921-167972023:+	AFDN	32;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008022,molecular_function protein C-terminus binding;GO:0016607,cellular_component nuclear speck;GO:0017016,molecular_function Ras GTPase binding;GO:0021537,biological_process telencephalon development;GO:0021987,biological_process cerebral cortex development;GO:0030054,cellular_component cell junction;GO:0032880,biological_process regulation of protein localization;GO:0034332,biological_process adherens junction organization;GO:0034334,biological_process adherens junction maintenance;GO:0043296,cellular_component apical junction complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045177,cellular_component apical part of cell;GO:0045296,molecular_function cadherin binding;GO:0048854,biological_process brain morphogenesis;GO:0048872,biological_process homeostasis of number of cells;GO:0050839,molecular_function cell adhesion molecule binding;GO:0060019,biological_process radial glial cell differentiation;GO:0060563,biological_process neuroepithelial cell differentiation;GO:0070445,biological_process regulation of oligodendrocyte progenitor proliferation;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:1902414,biological_process protein localization to cell junction	AF6, MLLT4; afadin; K05702	afadin%2C adherens junction formation factor [Source:HGNC Symbol%3BAcc:HGNC:7137]
ENSG00000008952	68.37	64.87	66.65	61.57	69.70	63.05	0.0537670754360026	6.46899375555314	0.441469992276469	0.789922884439889	3:169966634-169998373:+	SEC62	13;GO:0004872,molecular_function receptor activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0006620,biological_process posttranslational protein targeting to membrane;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response	SEC62; translocation protein SEC62; K12275	SEC62 homolog%2C preprotein translocation factor [Source:HGNC Symbol%3BAcc:HGNC:11846]
ENSG00000157778	45.54	39.43	48.46	49.30	44.76	48.61	-0.0765627605443986	4.09292192512324	0.441511719346166	0.789922884439889	7:1567329-1571005:-	PSMG3	1;GO:0000502,cellular_component proteasome complex	NA	proteasome assembly chaperone 3 [Source:HGNC Symbol%3BAcc:HGNC:22420]
ENSG00000129250	33.81	37.80	35.23	34.62	35.34	33.92	0.0507062257520365	6.86256366974867	0.441670195445041	0.790059974086664	17:4997947-5028401:+	KIF1C	17;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity;GO:0030705,biological_process cytoskeleton-dependent intracellular transport	NA	kinesin family member 1C [Source:HGNC Symbol%3BAcc:HGNC:6317]
ENSG00000159788	8.68	8.24	7.90	9.42	8.74	7.99	-0.0626702435934982	5.23396841208105	0.441831735698267	0.790059974086664	4:3293027-3439913:+	RGS12	20;GO:0000794,cellular_component condensed nuclear chromosome;GO:0005057,molecular_function receptor signaling protein activity;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016363,cellular_component nuclear matrix;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0030695,molecular_function GTPase regulator activity;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0050790,biological_process regulation of catalytic activity	NA	regulator of G protein signaling 12 [Source:HGNC Symbol%3BAcc:HGNC:9994]
ENSG00000169410	16.35	15.98	16.89	18.83	16.42	16.60	-0.061467838989953	5.08546903280628	0.441886252504191	0.790059974086664	15:75463250-75579289:-	PTPN9	10;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation	NA	protein tyrosine phosphatase%2C non-receptor type 9 [Source:HGNC Symbol%3BAcc:HGNC:9661]
ENSG00000204936	0.85	1.50	1.47	1.44	2.05	1.05	-0.24950181717217	1.06468834229652	0.442018266776552	0.790059974086664	19:43353658-43363172:+	CD177	10;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0031225,cellular_component anchored component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane	NA	CD177 molecule [Source:HGNC Symbol%3BAcc:HGNC:30072]
ENSG00000164093	10.29	9.95	10.87	10.38	9.23	10.16	0.078246497721146	3.97869769779199	0.442112857698946	0.790059974086664	4:110617422-110642123:-	PITX2	77;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001569,biological_process patterning of blood vessels;GO:0001570,biological_process vasculogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001764,biological_process neuron migration;GO:0002074,biological_process extraocular skeletal muscle development;GO:0003171,biological_process atrioventricular valve development;GO:0003253,biological_process cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:0003350,biological_process pulmonary myocardium development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007519,biological_process skeletal muscle tissue development;GO:0007520,biological_process myoblast fusion;GO:0008134,molecular_function transcription factor binding;GO:0008584,biological_process male gonad development;GO:0008585,biological_process female gonad development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009725,biological_process response to hormone;GO:0009887,biological_process organ morphogenesis;GO:0016055,biological_process Wnt signaling pathway;GO:0021763,biological_process subthalamic nucleus development;GO:0021855,biological_process hypothalamus cell migration;GO:0021983,biological_process pituitary gland development;GO:0030182,biological_process neuron differentiation;GO:0030324,biological_process lung development;GO:0030334,biological_process regulation of cell migration;GO:0031076,biological_process embryonic camera-type eye development;GO:0031490,molecular_function chromatin DNA binding;GO:0033189,biological_process response to vitamin A;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035315,biological_process hair cell differentiation;GO:0035886,biological_process vascular smooth muscle cell differentiation;GO:0035993,biological_process deltoid tuberosity development;GO:0042127,biological_process regulation of cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042476,biological_process odontogenesis;GO:0043010,biological_process camera-type eye development;GO:0043388,biological_process positive regulation of DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048536,biological_process spleen development;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048738,biological_process cardiac muscle tissue development;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055009,biological_process atrial cardiac muscle tissue morphogenesis;GO:0055015,biological_process ventricular cardiac muscle cell development;GO:0055123,biological_process digestive system development;GO:0060126,biological_process somatotropin secreting cell differentiation;GO:0060127,biological_process prolactin secreting cell differentiation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060460,biological_process left lung morphogenesis;GO:0060577,biological_process pulmonary vein morphogenesis;GO:0060578,biological_process superior vena cava morphogenesis;GO:0061031,biological_process endodermal digestive tract morphogenesis;GO:0061072,biological_process iris morphogenesis;GO:0061325,biological_process cell proliferation involved in outflow tract morphogenesis;GO:0070986,biological_process left/right axis specification;GO:2000288,biological_process positive regulation of myoblast proliferation	PITX2; paired-like homeodomain transcription factor 2; K04686	paired like homeodomain 2 [Source:HGNC Symbol%3BAcc:HGNC:9005]
ENSG00000079931	121.38	122.01	120.51	116.81	123.22	115.24	0.0463640594877758	7.89258183862343	0.442191858960595	0.790059974086664	6:132296054-132401545:-	MOXD1	18;GO:0003824,molecular_function catalytic activity;GO:0004497,molecular_function monooxygenase activity;GO:0004500,molecular_function dopamine beta-monooxygenase activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006589,biological_process octopamine biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016715,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen;GO:0030667,cellular_component secretory granule membrane;GO:0042420,biological_process dopamine catabolic process;GO:0042421,biological_process norepinephrine biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	monooxygenase DBH like 1 [Source:HGNC Symbol%3BAcc:HGNC:21063]
ENSG00000170876	34.60	33.03	33.99	34.46	32.45	31.86	0.0545740876067442	5.53846069399992	0.442246041027272	0.790059974086664	3:14124939-14143679:+	TMEM43	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043621,molecular_function protein self-association;GO:0071763,biological_process nuclear membrane organization	NA	transmembrane protein 43 [Source:HGNC Symbol%3BAcc:HGNC:28472]
ENSG00000170037	16.47	18.31	18.67	17.71	19.73	18.62	-0.0586049083088929	5.76189381277801	0.442336275707592	0.790059974086664	17:7932100-7949918:+	CNTROB	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007099,biological_process centriole replication;GO:0019904,molecular_function protein domain specific binding;GO:0051299,biological_process centrosome separation;GO:0051301,biological_process cell division;GO:1902410,biological_process mitotic cytokinetic process	NA	centrobin%2C centriole duplication and spindle assembly protein [Source:HGNC Symbol%3BAcc:HGNC:29616]
ENSG00000104695	72.89	73.02	73.45	79.68	70.36	79.35	-0.0531837285295326	6.22325826443257	0.442389763314982	0.790059974086664	8:30774456-30814314:-	PPP2CB	23;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000922,cellular_component spindle pole;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006470,biological_process protein dephosphorylation;GO:0008022,molecular_function protein C-terminus binding;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0010468,biological_process regulation of gene expression;GO:0016787,molecular_function hydrolase activity;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042542,biological_process response to hydrogen peroxide;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046677,biological_process response to antibiotic;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]; K04382	protein phosphatase 2 catalytic subunit beta [Source:HGNC Symbol%3BAcc:HGNC:9300]
ENSG00000108511	29.85	34.84	28.59	28.19	26.86	33.38	0.0797693333109322	4.35451914425584	0.442405680341014	0.790059974086664	17:48595750-48604992:-	HOXB6	13;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0034101,biological_process erythrocyte homeostasis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development	NA	homeobox B6 [Source:HGNC Symbol%3BAcc:HGNC:5117]
ENSG00000111678	92.27	81.85	91.36	91.64	80.29	84.99	0.0632522683140099	5.33179108531274	0.442481879669721	0.790059974086664	12:6942977-6946003:+	C12orf57	9;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0009791,biological_process post-embryonic development;GO:0014819,biological_process regulation of skeletal muscle contraction;GO:0021540,biological_process corpus callosum morphogenesis;GO:0021678,biological_process third ventricle development;GO:0036343,biological_process psychomotor behavior;GO:0048593,biological_process camera-type eye morphogenesis;GO:0050890,biological_process cognition	NA	chromosome 12 open reading frame 57 [Source:HGNC Symbol%3BAcc:HGNC:29521]
ENSG00000107951	15.82	15.08	14.09	15.23	14.69	17.71	-0.0721324206761968	4.77013768190689	0.442491810688199	0.790059974086664	10:30309800-30374448:-	MTPAP	20;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002134,molecular_function UTP binding;GO:0003723,molecular_function RNA binding;GO:0004652,molecular_function polynucleotide adenylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0030145,molecular_function manganese ion binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0071044,biological_process histone mRNA catabolic process	NA	mitochondrial poly(A) polymerase [Source:HGNC Symbol%3BAcc:HGNC:25532]
ENSG00000283297	2.55	3.03	2.25	2.29	2.24	2.23	0.206281092833845	1.23739583724937	0.442599905282787	0.790059974086664	12:2849038-2857083:-	AC005841.2	NA	NA	Uncharacterized protein ENSP00000372125  [Source:UniProtKB/Swiss-Prot%3BAcc:A6NCN8]
ENSG00000110274	5.61	5.37	5.74	6.04	5.51	6.02	-0.0572612848425065	5.12416383673014	0.442656446481599	0.790059974086664	11:117314556-117413268:+	CEP164	20;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016607,cellular_component nuclear speck;GO:0030030,biological_process cell projection organization;GO:0051301,biological_process cell division;GO:0060271,biological_process cilium morphogenesis;GO:0097539,cellular_component ciliary transition fiber;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 164 [Source:HGNC Symbol%3BAcc:HGNC:29182]
ENSG00000178397	26.28	29.03	25.58	26.87	30.07	28.31	-0.069380911918413	4.77059556359702	0.442940215244455	0.790059974086664	7:6329408-6348981:-	FAM220A	5;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005634,cellular_component nucleus;GO:0006470,biological_process protein dephosphorylation;GO:0032092,biological_process positive regulation of protein binding;GO:0097677,molecular_function STAT family protein binding	NA	family with sequence similarity 220 member A [Source:HGNC Symbol%3BAcc:HGNC:22422]
ENSG00000114988	33.05	35.27	31.68	32.43	37.92	34.84	-0.0644133975812261	5.22828373525626	0.442970507564494	0.790059974086664	2:96705928-96740064:-	LMAN2L	13;GO:0000139,cellular_component Golgi membrane;GO:0005537,molecular_function mannose binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006457,biological_process protein folding;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	NA	lectin%2C mannose binding 2 like [Source:HGNC Symbol%3BAcc:HGNC:19263]
ENSG00000133789	19.39	17.64	20.04	18.23	18.10	19.00	0.0609534180869711	5.1386284819228	0.443004963518124	0.790059974086664	11:9664076-9752991:+	SWAP70	23;GO:0003677,molecular_function DNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008064,biological_process regulation of actin polymerization or depolymerization;GO:0016020,cellular_component membrane;GO:0016444,biological_process somatic cell DNA recombination;GO:0030027,cellular_component lamellipodium;GO:0030835,biological_process negative regulation of actin filament depolymerization;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0032880,biological_process regulation of protein localization;GO:0033633,biological_process negative regulation of cell-cell adhesion mediated by integrin;GO:0042995,cellular_component cell projection;GO:0045190,biological_process isotype switching;GO:0045296,molecular_function cadherin binding;GO:0051017,biological_process actin filament bundle assembly;GO:0060754,biological_process positive regulation of mast cell chemotaxis;GO:1902309,biological_process negative regulation of peptidyl-serine dephosphorylation	NA	SWAP switching B-cell complex subunit 70 [Source:HGNC Symbol%3BAcc:HGNC:17070]
ENSG00000072849	40.03	42.39	43.17	41.66	40.71	39.42	0.0550093278001824	5.31971143899653	0.443071925329113	0.790059974086664	17:5471250-5486811:-	DERL2	22;GO:0001967,biological_process suckling behavior;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005785,cellular_component signal recognition particle receptor complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006508,biological_process proteolysis;GO:0006986,biological_process response to unfolded protein;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030307,biological_process positive regulation of cell growth;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0048500,cellular_component signal recognition particle;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol;GO:1904380,biological_process endoplasmic reticulum mannose trimming	NA	derlin 2 [Source:HGNC Symbol%3BAcc:HGNC:17943]
ENSG00000089022	17.71	16.62	17.13	21.00	16.28	17.45	-0.0754129094633804	4.78540686342298	0.443089556955891	0.790059974086664	12:111841977-111902238:+	MAPKAPK5	33;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0009931,molecular_function calcium-dependent protein serine/threonine kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0046777,biological_process protein autophosphorylation;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051973,biological_process positive regulation of telomerase activity;GO:0090400,biological_process stress-induced premature senescence;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904355,biological_process positive regulation of telomere capping	MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]; K04442	mitogen-activated protein kinase-activated protein kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:6889]
ENSG00000087095	11.06	11.01	11.18	9.75	11.15	10.97	0.0726263771223791	4.18935040966362	0.443277274201844	0.790059974086664	17:28041736-28196381:+	NLK	33;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0008134,molecular_function transcription factor binding;GO:0010468,biological_process regulation of gene expression;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035556,biological_process intracellular signal transduction;GO:0042169,molecular_function SH2 domain binding;GO:0042501,biological_process serine phosphorylation of STAT protein;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization	NLK; nemo like kinase [EC:2.7.11.24]; K04468	nemo like kinase [Source:HGNC Symbol%3BAcc:HGNC:29858]
ENSG00000111880	9.42	11.89	9.24	12.07	10.79	9.85	-0.0957073769809579	4.24647953634886	0.443429813234994	0.790059974086664	6:88610271-88963721:-	RNGTT	25;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004484,molecular_function mRNA guanylyltransferase activity;GO:0004651,molecular_function polynucleotide 5'-phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008152,biological_process metabolic process;GO:0008192,molecular_function RNA guanylyltransferase activity;GO:0016032,biological_process viral process;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0050355,molecular_function triphosphatase activity;GO:0098507,biological_process polynucleotide 5' dephosphorylation	RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.-]; K13917	RNA guanylyltransferase and 5'-phosphatase [Source:HGNC Symbol%3BAcc:HGNC:10073]
ENSG00000162378	8.41	8.30	8.17	8.61	8.04	7.11	0.0790821059966873	4.19047022140478	0.443471047582671	0.790059974086664	1:52726466-52827342:+	ZYG11B	4;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0051438,biological_process regulation of ubiquitin-protein transferase activity	NA	zyg-11 family member B%2C cell cycle regulator [Source:HGNC Symbol%3BAcc:HGNC:25820]
ENSG00000164142	2.56	3.28	2.55	3.48	3.14	2.55	-0.126341977880633	3.20600816822669	0.443475329342174	0.790059974086664	4:151409215-151663632:+	FAM160A1	NA	NA	family with sequence similarity 160 member A1 [Source:HGNC Symbol%3BAcc:HGNC:34237]
ENSG00000197530	10.19	11.01	10.96	10.36	10.26	10.53	0.0546568488101733	5.18985582404124	0.443613473975903	0.790059974086664	1:1615414-1630610:+	MIB2	17;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0007219,biological_process Notch signaling pathway;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	mindbomb E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:30577]
ENSG00000100983	53.14	56.12	52.22	55.60	56.64	56.08	-0.0500372103096497	6.29160096342533	0.443731889406899	0.790059974086664	20:34928429-34955817:-	GSS	24;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004363,molecular_function glutathione synthase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0006979,biological_process response to oxidative stress;GO:0007399,biological_process nervous system development;GO:0007568,biological_process aging;GO:0009410,biological_process response to xenobiotic stimulus;GO:0016594,molecular_function glycine binding;GO:0016874,molecular_function ligase activity;GO:0031667,biological_process response to nutrient levels;GO:0034612,biological_process response to tumor necrosis factor;GO:0042277,molecular_function peptide binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043200,biological_process response to amino acid;GO:0043295,molecular_function glutathione binding;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	gshB; glutathione synthase [EC:6.3.2.3]; K01920	glutathione synthetase [Source:HGNC Symbol%3BAcc:HGNC:4624]
ENSG00000172663	23.45	20.25	24.82	21.67	19.60	23.98	0.0879770280131953	4.12696861357633	0.443766144884682	0.790059974086664	11:67461709-67469272:-	TMEM134	4;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	transmembrane protein 134 [Source:HGNC Symbol%3BAcc:HGNC:26142]
ENSG00000130023	14.95	12.22	14.36	15.60	13.21	15.32	-0.0701679212040646	4.92655820524747	0.443781853901256	0.790059974086664	6:169751621-169781584:+	ERMARD	7;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ER membrane associated RNA degradation [Source:HGNC Symbol%3BAcc:HGNC:21056]
ENSG00000197483	1.80	2.13	2.57	2.07	1.88	2.06	0.12273301964882	2.76122450302276	0.443819799826973	0.790059974086664	19:55476331-55484487:+	ZNF628	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 628 [Source:HGNC Symbol%3BAcc:HGNC:28054]
ENSG00000228727	25.26	26.13	32.39	32.95	26.84	30.55	-0.0945403790381576	3.97184320446566	0.443833178396248	0.790059974086664	6:31762798-31764851:+	SAPCD1	NA	NA	suppressor APC domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:13938]
ENSG00000126001	11.07	11.24	11.09	11.55	11.46	11.79	-0.0481514639267366	6.41681753912498	0.443870566719696	0.790059974086664	20:35455163-35519280:+	CEP250	26;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007049,biological_process cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0008104,biological_process protein localization;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010457,biological_process centriole-centriole cohesion;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030997,biological_process regulation of centriole-centriole cohesion;GO:0033365,biological_process protein localization to organelle;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1904781,biological_process positive regulation of protein localization to centrosome;GO:1905515,biological_process non-motile cilium assembly	NA	centrosomal protein 250 [Source:HGNC Symbol%3BAcc:HGNC:1859]
ENSG00000139410	4.91	4.43	4.37	4.90	5.27	4.96	-0.125179174159236	2.30398298185407	0.443870851473324	0.790059974086664	12:113422236-113438276:+	SDSL	10;GO:0003674,molecular_function molecular_function;GO:0003941,molecular_function L-serine ammonia-lyase activity;GO:0004794,molecular_function L-threonine ammonia-lyase activity;GO:0005739,cellular_component mitochondrion;GO:0006520,biological_process cellular amino acid metabolic process;GO:0008150,biological_process biological_process;GO:0016829,molecular_function lyase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042802,molecular_function identical protein binding;GO:0070062,cellular_component extracellular exosome	NA	serine dehydratase like [Source:HGNC Symbol%3BAcc:HGNC:30404]
ENSG00000153130	46.61	46.12	53.69	48.87	50.61	55.53	-0.0684869297308899	4.79150030762617	0.443923656091689	0.790059974086664	4:140257285-140385726:+	SCOC	11;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0061635,biological_process regulation of protein complex stability	NA	short coiled-coil protein [Source:HGNC Symbol%3BAcc:HGNC:20335]
ENSG00000136933	17.41	17.52	15.42	16.09	15.59	16.72	0.0652783395381006	4.62328644595231	0.444066949249102	0.790059974086664	9:125200541-125234158:+	RABEPK	9;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0030133,cellular_component transport vesicle;GO:0032588,cellular_component trans-Golgi network membrane	NA	Rab9 effector protein with kelch motifs [Source:HGNC Symbol%3BAcc:HGNC:16896]
ENSG00000134046	37.55	35.77	35.83	36.69	37.82	39.48	-0.0501587260954852	5.81890845078065	0.444146359179745	0.790059974086664	18:54151600-54224788:-	MBD2	42;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000792,cellular_component heterochromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003696,molecular_function satellite DNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006346,biological_process methylation-dependent chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007507,biological_process heart development;GO:0007568,biological_process aging;GO:0008327,molecular_function methyl-CpG binding;GO:0009612,biological_process response to mechanical stimulus;GO:0014070,biological_process response to organic cyclic compound;GO:0019904,molecular_function protein domain specific binding;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031667,biological_process response to nutrient levels;GO:0032355,biological_process response to estradiol;GO:0035197,molecular_function siRNA binding;GO:0035563,biological_process positive regulation of chromatin binding;GO:0042127,biological_process regulation of cell proliferation;GO:0042711,biological_process maternal behavior;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0043623,biological_process cellular protein complex assembly;GO:0044030,biological_process regulation of DNA methylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048568,biological_process embryonic organ development;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0071407,biological_process cellular response to organic cyclic compound	NA	methyl-CpG binding domain protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6917]
ENSG00000182378	3.50	3.65	3.34	3.86	4.30	3.63	-0.159480473583833	1.90689504586889	0.444274658956374	0.790059974086664	X:276321-303356:+	PLCXD1	3;GO:0005737,cellular_component cytoplasm;GO:0006629,biological_process lipid metabolic process;GO:0008081,molecular_function phosphoric diester hydrolase activity	NA	phosphatidylinositol specific phospholipase C X domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23148]
ENSG00000185955	1.40	1.19	1.28	1.12	1.13	0.87	0.333949489972386	0.123580643929208	0.444309415585225	0.790059974086664	7:100456614-100464271:-	C7orf61	1;GO:0005634,cellular_component nucleus	NA	chromosome 7 open reading frame 61 [Source:HGNC Symbol%3BAcc:HGNC:22135]
ENSG00000173692	38.95	44.58	36.57	40.65	45.48	40.26	-0.0636605533467015	6.94539325043613	0.444316775211749	0.790059974086664	2:231056863-231172827:+	PSMD1	41;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0030234,molecular_function enzyme regulator activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034515,cellular_component proteasome storage granule;GO:0035578,cellular_component azurophil granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042176,biological_process regulation of protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050790,biological_process regulation of catalytic activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMD1, RPN2; 26S proteasome regulatory subunit N2; K03032	proteasome 26S subunit%2C non-ATPase 1 [Source:HGNC Symbol%3BAcc:HGNC:9554]
ENSG00000144681	38.42	30.75	35.40	41.53	30.00	40.58	-0.0861938465685642	5.45451483462948	0.444356195639818	0.790059974086664	3:36380343-36548007:+	STAC	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006936,biological_process muscle contraction;GO:0007165,biological_process signal transduction;GO:0030315,cellular_component T-tubule;GO:0034605,biological_process cellular response to heat;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:1901385,biological_process regulation of voltage-gated calcium channel activity	NA	SH3 and cysteine rich domain [Source:HGNC Symbol%3BAcc:HGNC:11353]
ENSG00000166589	25.21	24.02	29.06	24.07	27.01	24.60	0.0633822089270792	6.01457856504016	0.444376184781755	0.790059974086664	16:66908121-66918984:-	CDH16	13;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	cadherin 16 [Source:HGNC Symbol%3BAcc:HGNC:1755]
ENSG00000130244	11.02	10.57	9.97	10.47	9.63	9.89	0.0862644738168216	3.59853449598649	0.444381429339474	0.790059974086664	19:38403134-38409088:+	FAM98C	1;GO:0072669,cellular_component tRNA-splicing ligase complex	NA	family with sequence similarity 98 member C [Source:HGNC Symbol%3BAcc:HGNC:27119]
ENSG00000197006	131.48	146.02	126.54	125.20	144.76	119.73	0.0628457612247238	7.0761833026941	0.444393977464958	0.790059974086664	16:21597217-21657473:+	METTL9	1;GO:0005515,molecular_function protein binding	NA	methyltransferase like 9 [Source:HGNC Symbol%3BAcc:HGNC:24586]
ENSG00000105258	44.14	37.87	39.93	47.39	45.59	37.96	-0.0835828839317728	4.00332081769132	0.444435228400432	0.790059974086664	19:36113709-36115346:-	POLR2I	23;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001193,biological_process maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005730,cellular_component nucleolus;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006379,biological_process mRNA cleavage;GO:0008270,molecular_function zinc ion binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB9, POLR2I; DNA-directed RNA polymerase II subunit RPB9; K03017	RNA polymerase II subunit I [Source:HGNC Symbol%3BAcc:HGNC:9196]
ENSG00000117676	21.89	22.75	19.92	21.82	23.18	22.51	-0.0551926119578499	5.92435390455246	0.444445556056222	0.790059974086664	1:26529760-26575030:+	RPS6KA1	30;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030307,biological_process positive regulation of cell growth;GO:0035556,biological_process intracellular signal transduction;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043555,biological_process regulation of translation in response to stress;GO:0043620,biological_process regulation of DNA-templated transcription in response to stress;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0072574,biological_process hepatocyte proliferation;GO:2000491,biological_process positive regulation of hepatic stellate cell activation	RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]; K04373	ribosomal protein S6 kinase A1 [Source:HGNC Symbol%3BAcc:HGNC:10430]
ENSG00000189067	108.12	104.81	115.85	119.63	111.19	112.86	-0.0509896594673262	6.77087842412107	0.444490790598913	0.790059974086664	16:11547721-11636381:-	LITAF	40;GO:0000139,cellular_component Golgi membrane;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001817,biological_process regulation of cytokine production;GO:0003677,molecular_function DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007568,biological_process aging;GO:0008270,molecular_function zinc ion binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050699,molecular_function WW domain binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0098559,cellular_component cytoplasmic side of early endosome membrane;GO:0098560,cellular_component cytoplasmic side of late endosome membrane;GO:0098574,cellular_component cytoplasmic side of lysosomal membrane	NA	lipopolysaccharide induced TNF factor [Source:HGNC Symbol%3BAcc:HGNC:16841]
ENSG00000091986	49.97	45.06	46.00	51.65	45.73	50.22	-0.0531793359614827	7.17846162234106	0.444563760310026	0.790059974086664	3:112596793-112649530:-	CCDC80	12;GO:0001968,molecular_function fibronectin binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005614,cellular_component interstitial matrix;GO:0005615,cellular_component extracellular space;GO:0008201,molecular_function heparin binding;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization	NA	coiled-coil domain containing 80 [Source:HGNC Symbol%3BAcc:HGNC:30649]
ENSG00000167625	5.66	6.56	5.20	5.07	5.85	5.42	0.0941413610408363	3.51229002895406	0.444592924180401	0.790059974086664	19:42220270-42228201:+	ZNF526	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 526 [Source:HGNC Symbol%3BAcc:HGNC:29415]
ENSG00000105968	300.88	307.45	285.41	304.06	319.50	308.16	-0.049036378371638	7.07349390100726	0.444605403824033	0.790059974086664	7:44826790-44848083:-	H2AFV	10;GO:0000786,cellular_component nucleosome;GO:0000790,cellular_component nuclear chromatin;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006342,biological_process chromatin silencing;GO:0008150,biological_process biological_process;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome	H2A; histone H2A; K11251	H2A histone family member V [Source:HGNC Symbol%3BAcc:HGNC:20664]
ENSG00000175352	6.96	6.78	7.54	6.99	9.17	7.30	-0.122346531728538	2.54553320745013	0.444643436636545	0.790059974086664	11:8980575-9004049:-	NRIP3	3;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0006508,biological_process proteolysis	NA	nuclear receptor interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:1167]
ENSG00000158161	10.11	9.90	10.81	9.07	10.40	10.10	0.07403810203368	4.21168938103352	0.444807198060805	0.790237834482436	1:27970343-28088696:-	EYA3	26;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006470,biological_process protein dephosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007275,biological_process multicellular organism development;GO:0007601,biological_process visual perception;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010212,biological_process response to ionizing radiation;GO:0016569,biological_process covalent chromatin modification;GO:0016576,biological_process histone dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0045739,biological_process positive regulation of DNA repair;GO:0046872,molecular_function metal ion binding;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	NA	EYA transcriptional coactivator and phosphatase 3 [Source:HGNC Symbol%3BAcc:HGNC:3521]
ENSG00000008988	2202.02	2004.79	2044.48	2266.22	2052.87	2202.08	-0.0491729913556581	9.93348590804877	0.444915244274725	0.790316675326583	8:56067294-56074581:-	RPS20	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	RP-S20e, RPS20; small subunit ribosomal protein S20e; K02969	ribosomal protein S20 [Source:HGNC Symbol%3BAcc:HGNC:10405]
ENSG00000102030	37.60	45.66	39.65	34.45	44.03	38.68	0.0760100307688409	4.98378890786538	0.445032744994898	0.790412285537512	X:153929241-153935223:-	NAA10	23;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006323,biological_process DNA packaging;GO:0006473,biological_process protein acetylation;GO:0006474,biological_process N-terminal protein amino acid acetylation;GO:0006475,biological_process internal protein amino acid acetylation;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016020,cellular_component membrane;GO:0016407,molecular_function acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017198,biological_process N-terminal peptidyl-serine acetylation;GO:0018002,biological_process N-terminal peptidyl-glutamic acid acetylation;GO:0022626,cellular_component cytosolic ribosome;GO:0031415,cellular_component NatA complex;GO:0043022,molecular_function ribosome binding;GO:1990189,molecular_function peptide-serine-N-acetyltransferase activity;GO:1990190,molecular_function peptide-glutamate-N-acetyltransferase activity	NA	N(alpha)-acetyltransferase 10%2C NatA catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:18704]
ENSG00000120526	32.44	34.08	34.49	36.97	32.60	36.10	-0.0544331445986833	5.98331713932918	0.445160649424176	0.790448017457098	8:109240918-109334385:-	NUDCD1	6;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	NudC domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24306]
ENSG00000171241	16.71	19.72	15.22	16.53	21.78	16.99	-0.0903861551667269	5.17045667815684	0.445180221545361	0.790448017457098	16:46580553-46621626:-	SHCBP1	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0030496,cellular_component midbody;GO:0042169,molecular_function SH2 domain binding;GO:2000177,biological_process regulation of neural precursor cell proliferation	NA	SHC binding and spindle associated 1 [Source:HGNC Symbol%3BAcc:HGNC:29547]
ENSG00000165632	8.67	9.19	8.71	10.26	8.98	8.83	-0.0698304706274436	4.67422756427181	0.445479646618494	0.79056377003581	10:7818503-8016627:+	TAF3	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002039,molecular_function p53 binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0031965,cellular_component nuclear membrane;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0046872,molecular_function metal ion binding;GO:0051457,biological_process maintenance of protein location in nucleus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF3; transcription initiation factor TFIID subunit 3; K14650	TATA-box binding protein associated factor 3 [Source:HGNC Symbol%3BAcc:HGNC:17303]
ENSG00000152102	35.61	27.93	34.98	32.64	35.78	37.02	-0.0765692102744499	4.33191713289088	0.44551508984331	0.79056377003581	2:131047875-131093460:-	FAM168B	8;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030424,cellular_component axon;GO:0042995,cellular_component cell projection;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	family with sequence similarity 168 member B [Source:HGNC Symbol%3BAcc:HGNC:27016]
ENSG00000228696	0.67	1.36	1.49	0.98	0.99	0.84	0.315373464567802	0.0378175581121241	0.445517308350569	0.79056377003581	17:46274783-46361797:-	ARL17B	8;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport	NA	ADP ribosylation factor like GTPase 17B [Source:HGNC Symbol%3BAcc:HGNC:32387]
ENSG00000168395	12.35	13.51	15.75	15.11	14.25	15.18	-0.0863041981077294	3.96454679464746	0.445581178747222	0.79056377003581	2:241687084-241729478:+	ING5	20;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006473,biological_process protein acetylation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0035064,molecular_function methylated histone binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043966,biological_process histone H3 acetylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045926,biological_process negative regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0070776,cellular_component MOZ/MORF histone acetyltransferase complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	inhibitor of growth family member 5 [Source:HGNC Symbol%3BAcc:HGNC:19421]
ENSG00000161202	30.70	29.64	31.72	29.77	28.62	31.26	0.0510302669250434	6.07455545143246	0.44558180187178	0.79056377003581	3:184155387-184173610:+	DVL3	27;GO:0000790,cellular_component nuclear chromatin;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002020,molecular_function protease binding;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0008013,molecular_function beta-catenin binding;GO:0016055,biological_process Wnt signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0038031,biological_process non-canonical Wnt signaling pathway via JNK cascade;GO:0042493,biological_process response to drug;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0048365,molecular_function Rac GTPase binding;GO:0050821,biological_process protein stabilization;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:1903827,biological_process regulation of cellular protein localization;GO:1904886,biological_process beta-catenin destruction complex disassembly	DVL; segment polarity protein dishevelled; K02353	dishevelled segment polarity protein 3 [Source:HGNC Symbol%3BAcc:HGNC:3087]
ENSG00000109381	23.02	21.93	23.16	24.48	23.30	23.51	-0.0518347640015431	5.45432408724789	0.445627543618832	0.79056377003581	4:139028111-139177218:-	ELF2	15;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016604,cellular_component nuclear body;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050855,biological_process regulation of B cell receptor signaling pathway	ELF1_2_4; E74-like factor 1/2/4; K09428	E74 like ETS transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:3317]
ENSG00000141934	6.32	7.12	5.41	6.33	4.22	6.57	0.139376266992664	2.62318503076527	0.445915935219023	0.790798987202011	19:281039-291504:-	PLPP2	16;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006644,biological_process phospholipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0042392,molecular_function sphingosine-1-phosphate phosphatase activity;GO:0042577,molecular_function lipid phosphatase activity;GO:0046839,biological_process phospholipid dephosphorylation	PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]; K01080	phospholipid phosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:9230]
ENSG00000067445	6.42	6.57	7.48	6.24	7.13	6.31	0.0703605810089345	4.8962289732785	0.445945211958103	0.790798987202011	X:54920461-54931431:+	TRO	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007566,biological_process embryo implantation;GO:0030308,biological_process negative regulation of cell growth	NA	trophinin [Source:HGNC Symbol%3BAcc:HGNC:12326]
ENSG00000177425	25.78	22.81	24.76	24.50	26.35	26.57	-0.0611594821543655	4.78057048596107	0.446063385328678	0.790798987202011	12:79574978-79691097:-	PAWR	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0003714,molecular_function transcription corepressor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005884,cellular_component actin filament;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0019899,molecular_function enzyme binding;GO:0030889,biological_process negative regulation of B cell proliferation;GO:0042094,biological_process interleukin-2 biosynthetic process;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042986,biological_process positive regulation of amyloid precursor protein biosynthetic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043522,molecular_function leucine zipper domain binding;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0051017,biological_process actin filament bundle assembly;GO:0097190,biological_process apoptotic signaling pathway;GO:1901300,biological_process positive regulation of hydrogen peroxide-mediated programmed cell death;GO:2000774,biological_process positive regulation of cellular senescence	NA	pro-apoptotic WT1 regulator [Source:HGNC Symbol%3BAcc:HGNC:8614]
ENSG00000171475	21.08	25.92	21.24	22.75	23.33	18.80	0.0796301437106232	4.87463272560514	0.44615445899104	0.790798987202011	17:40219303-40284136:+	WIPF2	6;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis	NA	WAS/WASL interacting protein family member 2 [Source:HGNC Symbol%3BAcc:HGNC:30923]
ENSG00000182310	12.35	12.09	11.43	9.63	13.81	10.06	0.112373565346698	3.5076337281388	0.446222986819722	0.790798987202011	19:51693339-51712387:+	SPACA6	4;GO:0005515,molecular_function protein binding;GO:0007342,biological_process fusion of sperm to egg plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	sperm acrosome associated 6 [Source:HGNC Symbol%3BAcc:HGNC:27113]
ENSG00000166532	18.91	18.86	19.09	17.94	21.11	20.96	-0.0663881984474716	4.79825163769445	0.446232828122767	0.790798987202011	12:8681599-8783095:+	RIMKLB	11;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016874,molecular_function ligase activity;GO:0046872,molecular_function metal ion binding;GO:0072590,molecular_function N-acetyl-L-aspartate-L-glutamate ligase activity;GO:0072591,molecular_function citrate-L-glutamate ligase activity	NA	ribosomal modification protein rimK like family member B [Source:HGNC Symbol%3BAcc:HGNC:29228]
ENSG00000237515	8.08	9.06	9.76	9.44	9.56	9.79	-0.0890570015448399	3.6887887500773	0.446276023540458	0.790798987202011	16:12901619-13240413:+	SHISA9	14;GO:0005886,cellular_component plasma membrane;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0032591,cellular_component dendritic spine membrane;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	NA	shisa family member 9 [Source:HGNC Symbol%3BAcc:HGNC:37231]
ENSG00000214128	1.47	1.59	1.99	2.64	2.20	1.46	-0.297520319539828	0.089592677626995	0.446439272086279	0.790798987202011	7:138797951-138838101:+	TMEM213	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 213 [Source:HGNC Symbol%3BAcc:HGNC:27220]
ENSG00000136720	4.41	4.65	4.95	4.31	4.80	3.82	0.130343621742996	2.50550621910085	0.446449251950023	0.790798987202011	2:128236715-128318577:-	HS6ST1	14;GO:0000139,cellular_component Golgi membrane;GO:0001525,biological_process angiogenesis;GO:0005887,cellular_component integral component of plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0008146,molecular_function sulfotransferase activity;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0015015,biological_process heparan sulfate proteoglycan biosynthetic process, enzymatic modification;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0017095,molecular_function heparan sulfate 6-O-sulfotransferase activity;GO:0048286,biological_process lung alveolus development;GO:0048666,biological_process neuron development;GO:0060716,biological_process labyrinthine layer blood vessel development	HS6ST1; heparan sulfate 6-O-sulfotransferase HS6ST1 [EC:2.8.2.-]; K02514	heparan sulfate 6-O-sulfotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:5201]
ENSG00000110987	17.22	20.82	20.50	19.45	19.15	16.64	0.090910116081655	3.72810551782124	0.44645589849352	0.790798987202011	12:122019421-122062044:+	BCL7A	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	BCL tumor suppressor 7A [Source:HGNC Symbol%3BAcc:HGNC:1004]
ENSG00000163781	14.80	13.63	13.62	12.84	14.04	14.03	0.0529502812800337	5.98503051483107	0.446460912133384	0.790798987202011	3:133598174-133661893:-	TOPBP1	25;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000922,cellular_component spindle pole;GO:0001673,cellular_component male germ cell nucleus;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006259,biological_process DNA metabolic process;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0008022,molecular_function protein C-terminus binding;GO:0010212,biological_process response to ionizing radiation;GO:0015629,cellular_component actin cytoskeleton;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0033314,biological_process mitotic DNA replication checkpoint;GO:0042802,molecular_function identical protein binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TOPBP1; topoisomerase (DNA) II binding protein 1; K10728	topoisomerase (DNA) II binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17008]
ENSG00000163785	34.71	33.80	35.10	40.00	34.30	34.41	-0.0566221403521632	6.04984845630368	0.446718515205852	0.791142378263696	3:134065302-134250744:-	RYK	26;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005109,molecular_function frizzled binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0022038,biological_process corpus callosum development;GO:0030182,biological_process neuron differentiation;GO:0031175,biological_process neuron projection development;GO:0036518,biological_process chemorepulsion of dopaminergic neuron axon;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0048705,biological_process skeletal system morphogenesis;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0050919,biological_process negative chemotaxis;GO:0071679,biological_process commissural neuron axon guidance;GO:1904938,biological_process planar cell polarity pathway involved in axon guidance;GO:1904948,biological_process midbrain dopaminergic neuron differentiation	RYK; RYK receptor-like tyrosine kinase [EC:2.7.10.1]; K05128	receptor-like tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:10481]
ENSG00000141198	53.95	51.41	50.90	55.67	51.82	55.61	-0.0496333378897165	6.48031042811996	0.446804936023662	0.791182549338332	17:54899386-54961956:+	TOM1L1	24;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0019901,molecular_function protein kinase binding;GO:0030276,molecular_function clathrin binding;GO:0030295,molecular_function protein kinase activator activity;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032147,biological_process activation of protein kinase activity;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0045839,biological_process negative regulation of mitotic nuclear division;GO:0070062,cellular_component extracellular exosome	NA	target of myb1 like 1 membrane trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:11983]
ENSG00000168028	1792.48	1729.84	1724.56	1894.26	1745.64	1817.10	-0.0449201776027135	10.6499199014503	0.44703889454471	0.791413197236775	3:39406688-39412542:+	RPSA	38;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000447,biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000461,biological_process endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001618,molecular_function virus receptor activity;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005055,molecular_function laminin receptor activity;GO:0005515,molecular_function protein binding;GO:0005604,cellular_component basement membrane;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0006364,biological_process rRNA processing;GO:0006407,biological_process rRNA export from nucleus;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007155,biological_process cell adhesion;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030686,cellular_component 90S preribosome;GO:0030855,biological_process epithelial cell differentiation;GO:0031012,cellular_component extracellular matrix;GO:0043022,molecular_function ribosome binding;GO:0043025,cellular_component neuronal cell body;GO:0043236,molecular_function laminin binding;GO:0046718,biological_process viral entry into host cell;GO:0070062,cellular_component extracellular exosome	RP-SAe, RPSA; small subunit ribosomal protein SAe; K02998	ribosomal protein SA [Source:HGNC Symbol%3BAcc:HGNC:6502]
ENSG00000109171	16.94	16.84	18.66	17.18	17.57	20.69	-0.0678782736065912	5.04322143139589	0.44712915878478	0.791413197236775	4:48341321-48426212:+	SLAIN2	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007020,biological_process microtubule nucleation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0031113,biological_process regulation of microtubule polymerization;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0035371,cellular_component microtubule plus-end	NA	SLAIN motif family member 2 [Source:HGNC Symbol%3BAcc:HGNC:29282]
ENSG00000104432	4.73	7.04	5.55	6.52	5.72	7.07	-0.169804389616669	1.91739952705413	0.447191050001649	0.791413197236775	8:78675742-78805523:-	IL7	24;GO:0002360,biological_process T cell lineage commitment;GO:0005125,molecular_function cytokine activity;GO:0005126,molecular_function cytokine receptor binding;GO:0005139,molecular_function interleukin-7 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006955,biological_process immune response;GO:0006959,biological_process humoral immune response;GO:0007267,biological_process cell-cell signaling;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0010468,biological_process regulation of gene expression;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0045453,biological_process bone resorption;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0046622,biological_process positive regulation of organ growth;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IL7; interleukin 7; K05431	interleukin 7 [Source:HGNC Symbol%3BAcc:HGNC:6023]
ENSG00000115464	20.19	20.08	21.33	19.38	20.38	20.38	0.0466968081311908	7.75603143131407	0.447226837346288	0.791413197236775	2:61187462-61470769:-	USP34	14;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016055,biological_process Wnt signaling pathway;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	ubiquitin specific peptidase 34 [Source:HGNC Symbol%3BAcc:HGNC:20066]
ENSG00000181852	21.15	18.74	21.40	23.73	19.49	22.01	-0.0727308716349516	4.46257671548325	0.447253973947956	0.791413197236775	12:56202174-56221933:-	RNF41	36;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005128,molecular_function erythropoietin receptor binding;GO:0005135,molecular_function interleukin-3 receptor binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0010498,biological_process proteasomal protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016881,molecular_function acid-amino acid ligase activity;GO:0017160,molecular_function Ral GTPase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030336,biological_process negative regulation of cell migration;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031386,molecular_function protein tag;GO:0043408,biological_process regulation of MAPK cascade;GO:0045619,biological_process regulation of lymphocyte differentiation;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051865,biological_process protein autoubiquitination;GO:0051896,biological_process regulation of protein kinase B signaling;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1901525,biological_process negative regulation of macromitophagy;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000377,biological_process regulation of reactive oxygen species metabolic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]; K11981	ring finger protein 41 [Source:HGNC Symbol%3BAcc:HGNC:18401]
ENSG00000179632	101.56	91.50	102.31	102.68	99.98	106.04	-0.0500891299539523	6.83118695151694	0.447358644639006	0.791435596895301	8:144104498-144107611:+	MAF1	20;GO:0000994,molecular_function RNA polymerase III core binding;GO:0001030,molecular_function RNA polymerase III type 1 promoter DNA binding;GO:0001031,molecular_function RNA polymerase III type 2 promoter DNA binding;GO:0001032,molecular_function RNA polymerase III type 3 promoter DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016480,biological_process negative regulation of transcription from RNA polymerase III promoter;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050811,molecular_function GABA receptor binding;GO:0060077,cellular_component inhibitory synapse	NA	MAF1 homolog%2C negative regulator of RNA polymerase III [Source:HGNC Symbol%3BAcc:HGNC:24966]
ENSG00000082269	4.55	4.75	5.09	4.62	4.38	4.83	0.0676056907403988	4.47306262231975	0.447394149956846	0.791435596895301	6:70412940-70561174:+	FAM135A	2;GO:0044255,biological_process cellular lipid metabolic process;GO:0052689,molecular_function carboxylic ester hydrolase activity	NA	family with sequence similarity 135 member A [Source:HGNC Symbol%3BAcc:HGNC:21084]
ENSG00000166454	21.71	20.28	23.85	21.68	22.21	19.88	0.0614956831448417	5.74299641540797	0.447480587707343	0.791475710346431	16:81035846-81047358:+	ATMIN	14;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010628,biological_process positive regulation of gene expression;GO:0016604,cellular_component nuclear body;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044458,biological_process motile cilium assembly;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070840,molecular_function dynein complex binding;GO:1902857,biological_process positive regulation of nonmotile primary cilium assembly	NA	ATM interactor [Source:HGNC Symbol%3BAcc:HGNC:29034]
ENSG00000204856	11.64	8.63	14.56	13.62	12.59	12.28	-0.117997190161936	3.35701673257318	0.44755917045753	0.791501920913138	12:110468363-110490385:+	FAM216A	NA	NA	family with sequence similarity 216 member A [Source:HGNC Symbol%3BAcc:HGNC:30180]
ENSG00000119314	55.85	52.46	53.68	58.77	49.90	61.59	-0.0598033030637675	6.58175186949564	0.447893220554053	0.791979849962602	9:112217715-112333667:-	PTBP3	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030154,biological_process cell differentiation;GO:0033119,biological_process negative regulation of RNA splicing;GO:0043249,biological_process erythrocyte maturation;GO:0045595,biological_process regulation of cell differentiation	NA	polypyrimidine tract binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:10253]
ENSG00000017483	86.30	73.29	93.22	97.11	77.72	93.29	-0.0717822431621987	7.13366680989277	0.448016578768293	0.792085143462587	X:48458536-48470256:-	SLC38A5	9;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015187,molecular_function glycine transmembrane transporter activity;GO:0015816,biological_process glycine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	SLC38A5, SNAT5; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 5; K14992	solute carrier family 38 member 5 [Source:HGNC Symbol%3BAcc:HGNC:18070]
ENSG00000103034	0.86	0.88	0.51	0.60	0.70	0.57	0.26008600741431	0.412085408012974	0.448146275821399	0.792110876716755	16:58462845-58513628:+	NDRG4	26;GO:0001947,biological_process heart looping;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006950,biological_process response to stress;GO:0007420,biological_process brain development;GO:0008542,biological_process visual learning;GO:0010642,biological_process negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0016323,cellular_component basolateral plasma membrane;GO:0030154,biological_process cell differentiation;GO:0031253,cellular_component cell projection membrane;GO:0035050,biological_process embryonic heart tube development;GO:0048278,biological_process vesicle docking;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060973,biological_process cell migration involved in heart development;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:2001135,biological_process regulation of endocytic recycling	NA	NDRG family member 4 [Source:HGNC Symbol%3BAcc:HGNC:14466]
ENSG00000105397	18.53	18.21	20.93	18.52	18.85	18.69	0.0541517187641816	6.24843492377007	0.448239911438288	0.792110876716755	19:10350528-10380676:-	TYK2	30;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005131,molecular_function growth hormone receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0035556,biological_process intracellular signal transduction;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0045087,biological_process innate immune response;GO:0060337,biological_process type I interferon signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome	TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]; K11219	tyrosine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:12440]
ENSG00000177084	7.09	8.51	7.27	8.29	7.69	8.03	-0.0635804235654246	5.74611965987304	0.448313494453915	0.792110876716755	12:132623752-132687365:-	POLE	32;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006272,biological_process leading strand elongation;GO:0006281,biological_process DNA repair;GO:0006287,biological_process base-excision repair, gap-filling;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008270,molecular_function zinc ion binding;GO:0008310,molecular_function single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0008622,cellular_component epsilon DNA polymerase complex;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0045004,biological_process DNA replication proofreading;GO:0046872,molecular_function metal ion binding;GO:0048568,biological_process embryonic organ development;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0071897,biological_process DNA biosynthetic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]; K02324	DNA polymerase epsilon%2C catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9177]
ENSG00000186106	10.16	10.40	12.17	12.68	10.40	12.57	-0.110145043519581	3.11396264372264	0.448339045095329	0.792110876716755	8:100509751-100559784:-	ANKRD46	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ankyrin repeat domain 46 [Source:HGNC Symbol%3BAcc:HGNC:27229]
ENSG00000144736	9.47	11.11	11.18	11.08	10.80	11.82	-0.079521898800997	4.30436231793476	0.448363170638143	0.792110876716755	3:72749276-72861914:-	SHQ1	11;GO:0000493,biological_process box H/ACA snoRNP assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0022618,biological_process ribonucleoprotein complex assembly;GO:0043065,biological_process positive regulation of apoptotic process;GO:0051082,molecular_function unfolded protein binding;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body;GO:2000233,biological_process negative regulation of rRNA processing	NA	SHQ1%2C H/ACA ribonucleoprotein assembly factor [Source:HGNC Symbol%3BAcc:HGNC:25543]
ENSG00000008283	13.06	17.59	15.60	15.38	15.14	13.17	0.0859492874199873	4.19456860678951	0.448421011488441	0.792110876716755	17:63432303-63446378:-	CYB561	11;GO:0000293,molecular_function ferric-chelate reductase activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0022865,molecular_function transmembrane electron transfer carrier;GO:0022900,biological_process electron transport chain;GO:0046872,molecular_function metal ion binding;GO:0055085,biological_process transmembrane transport;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome b561 [Source:HGNC Symbol%3BAcc:HGNC:2571]
ENSG00000164070	21.17	25.64	24.11	21.70	23.83	22.95	0.0584051318886939	5.88876573803087	0.448477824987139	0.792110876716755	4:127781820-127840733:+	HSPA4L	7;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006986,biological_process response to unfolded protein	HSP110; heat shock protein 110kDa; K09485	heat shock protein family A (Hsp70) member 4 like [Source:HGNC Symbol%3BAcc:HGNC:17041]
ENSG00000158158	5.32	3.82	5.41	4.73	5.22	5.93	-0.10231272383556	3.59018913032828	0.448547993985522	0.792122101201064	2:96760901-96811891:+	CNNM4	16;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007601,biological_process visual perception;GO:0010960,biological_process magnesium ion homeostasis;GO:0015081,molecular_function sodium ion transmembrane transporter activity;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0031214,biological_process biomineral tissue development;GO:0035725,biological_process sodium ion transmembrane transport;GO:0050896,biological_process response to stimulus;GO:0070166,biological_process enamel mineralization;GO:1903830,biological_process magnesium ion transmembrane transport	NA	cyclin and CBS domain divalent metal cation transport mediator 4 [Source:HGNC Symbol%3BAcc:HGNC:105]
ENSG00000185024	11.54	12.01	10.47	12.79	11.29	11.78	-0.0683253949663808	4.81924546592936	0.448816046999501	0.792482729929559	14:105209285-105315589:-	BRF1	17;GO:0000126,cellular_component transcription factor TFIIIB complex;GO:0001026,molecular_function TFIIIB-type transcription factor activity;GO:0003743,molecular_function translation initiation factor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0006384,biological_process transcription initiation from RNA polymerase III promoter;GO:0006413,biological_process translational initiation;GO:0009303,biological_process rRNA transcription;GO:0009304,biological_process tRNA transcription;GO:0017025,molecular_function TBP-class protein binding;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0046872,molecular_function metal ion binding;GO:0070897,biological_process DNA-templated transcriptional preinitiation complex assembly	NA	BRF1%2C RNA polymerase III transcription initiation factor subunit [Source:HGNC Symbol%3BAcc:HGNC:11551]
ENSG00000123358	3.04	2.76	2.87	3.12	2.62	2.31	0.124697324682369	2.6862301988119	0.449097965908637	0.792867735858898	12:52022831-52059507:+	NR4A1	42;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0031965,cellular_component nuclear membrane;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0035767,biological_process endothelial cell chemotaxis;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045444,biological_process fat cell differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0061469,biological_process regulation of type B pancreatic cell proliferation;GO:0071310,biological_process cellular response to organic substance;GO:0071376,biological_process cellular response to corticotropin-releasing hormone stimulus	NR4A1, HMR; nuclear receptor subfamily 4 group A member 1; K04465	nuclear receptor subfamily 4 group A member 1 [Source:HGNC Symbol%3BAcc:HGNC:7980]
ENSG00000129749	0.65	1.35	0.57	0.64	0.70	0.75	0.258429093160681	0.283760213619767	0.449268834506559	0.793056604483777	11:3665586-3671384:-	CHRNA10	26;GO:0005102,molecular_function receptor binding;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005892,cellular_component acetylcholine-gated channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022848,molecular_function acetylcholine-gated cation channel activity;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0034220,biological_process ion transmembrane transport;GO:0042127,biological_process regulation of cell proliferation;GO:0042472,biological_process inner ear morphogenesis;GO:0043204,cellular_component perikaryon;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0050910,biological_process detection of mechanical stimulus involved in sensory perception of sound;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060079,biological_process excitatory postsynaptic potential;GO:0070588,biological_process calcium ion transmembrane transport	CHRNA10; nicotinic acetylcholine receptor alpha-10; K04811	cholinergic receptor nicotinic alpha 10 subunit [Source:HGNC Symbol%3BAcc:HGNC:13800]
ENSG00000185453	6.31	5.62	6.39	6.31	6.40	6.76	-0.0695268040150416	4.15105331953512	0.449468681923586	0.793187559557359	19:48170691-48197620:+	C19orf68	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding	NA	chromosome 19 open reading frame 68 [Source:HGNC Symbol%3BAcc:HGNC:34495]
ENSG00000152154	3.80	2.57	5.12	4.12	2.47	3.55	0.211385457765579	1.76694483062952	0.44947082042427	0.793187559557359	2:39664981-39717963:+	TMEM178A	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0051480,biological_process regulation of cytosolic calcium ion concentration	NA	transmembrane protein 178A [Source:HGNC Symbol%3BAcc:HGNC:28517]
ENSG00000164331	12.03	9.77	12.38	10.45	12.36	9.21	0.118439292299355	3.39846342279663	0.450030198981076	0.794061813781393	5:73552334-73565686:-	ANKRA2	16;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043234,cellular_component protein complex;GO:0043254,biological_process regulation of protein complex assembly;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:1990393,cellular_component 3M complex	NA	ankyrin repeat family A member 2 [Source:HGNC Symbol%3BAcc:HGNC:13208]
ENSG00000275395	0.38	0.42	0.54	0.46	0.51	0.51	-0.129708978675145	2.60360477936277	0.450173947740327	0.794113697257585	19:39863322-39934626:-	FCGBP	NA	NA	Fc fragment of IgG binding protein [Source:HGNC Symbol%3BAcc:HGNC:13572]
ENSG00000269556	16.83	17.10	16.08	13.54	17.57	16.49	0.0810750286435306	4.12237396938023	0.450229396900692	0.794113697257585	X:149596555-149631912:-	TMEM185A	5;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection	NA	transmembrane protein 185A [Source:HGNC Symbol%3BAcc:HGNC:17125]
ENSG00000091844	16.59	16.99	18.46	16.40	15.77	17.08	0.0912077626874183	3.4320273915174	0.450331462196482	0.794113697257585	6:153004458-153131249:-	RGS17	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043005,cellular_component neuron projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse	NA	regulator of G protein signaling 17 [Source:HGNC Symbol%3BAcc:HGNC:14088]
ENSG00000152464	19.79	23.86	21.87	23.77	24.51	21.29	-0.0807423069182727	4.32492498020947	0.450358535198064	0.794113697257585	10:15097179-15139818:+	RPP38	13;GO:0001650,cellular_component fibrillar center;GO:0001682,biological_process tRNA 5'-leader removal;GO:0004526,molecular_function ribonuclease P activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005655,cellular_component nucleolar ribonuclease P complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	RPP38; ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]; K14523	ribonuclease P/MRP subunit p38 [Source:HGNC Symbol%3BAcc:HGNC:30329]
ENSG00000145730	200.49	216.18	193.93	190.18	206.76	197.94	0.0491852168966911	9.19862903727515	0.450379475444566	0.794113697257585	5:102753980-103031105:+	PAM	53;GO:0001519,biological_process peptide amidation;GO:0001666,biological_process response to hypoxia;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004497,molecular_function monooxygenase activity;GO:0004504,molecular_function peptidylglycine monooxygenase activity;GO:0004598,molecular_function peptidylamidoglycolate lyase activity;GO:0005507,molecular_function copper ion binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006518,biological_process peptide metabolic process;GO:0007417,biological_process central nervous system development;GO:0007507,biological_process heart development;GO:0007595,biological_process lactation;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009268,biological_process response to pH;GO:0009404,biological_process toxin metabolic process;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016715,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen;GO:0016829,molecular_function lyase activity;GO:0018032,biological_process protein amidation;GO:0019538,biological_process protein metabolic process;GO:0019901,molecular_function protein kinase binding;GO:0022602,biological_process ovulation cycle process;GO:0030141,cellular_component secretory granule;GO:0030667,cellular_component secretory granule membrane;GO:0031418,molecular_function L-ascorbic acid binding;GO:0032355,biological_process response to estradiol;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0042476,biological_process odontogenesis;GO:0042493,biological_process response to drug;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043204,cellular_component perikaryon;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050708,biological_process regulation of protein secretion;GO:0051260,biological_process protein homooligomerization;GO:0051384,biological_process response to glucocorticoid;GO:0055114,biological_process oxidation-reduction process;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0060173,biological_process limb development;GO:0070062,cellular_component extracellular exosome	NA	peptidylglycine alpha-amidating monooxygenase [Source:HGNC Symbol%3BAcc:HGNC:8596]
ENSG00000182150	7.17	7.91	8.76	7.29	7.21	8.39	0.0688000370646261	5.09779135799912	0.45052989481876	0.794266096347858	9:95875700-96014571:+	ERCC6L2	20;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0036297,biological_process interstrand cross-link repair;GO:0043234,cellular_component protein complex	NA	ERCC excision repair 6 like 2 [Source:HGNC Symbol%3BAcc:HGNC:26922]
ENSG00000125352	14.62	15.05	15.74	16.30	14.37	17.63	-0.0796850635644939	4.02246717672233	0.450624074770029	0.79429269068747	X:119870474-119871827:-	RNF113A	5;GO:0005515,molecular_function protein binding;GO:0005684,cellular_component U2-type spliceosomal complex;GO:0034247,biological_process snoRNA splicing;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 113A [Source:HGNC Symbol%3BAcc:HGNC:12974]
ENSG00000168883	28.43	28.36	28.66	29.28	29.62	30.23	-0.0492825693952137	5.67483790087647	0.450672957424624	0.79429269068747	2:85602855-85649282:+	USP39	13;GO:0000245,biological_process spliceosomal complex assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016579,biological_process protein deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	USP39, SAD1; U4/U6.U5 tri-snRNP-associated protein 2; K12847	ubiquitin specific peptidase 39 [Source:HGNC Symbol%3BAcc:HGNC:20071]
ENSG00000168036	194.85	188.89	189.64	197.10	197.10	201.17	-0.0424290974608827	8.83556024900967	0.450849727379964	0.794452805757191	3:41194836-41260096:+	CTNNB1	260;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000578,biological_process embryonic axis specification;GO:0000904,biological_process cell morphogenesis involved in differentiation;GO:0000922,cellular_component spindle pole;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001501,biological_process skeletal system development;GO:0001569,biological_process patterning of blood vessels;GO:0001570,biological_process vasculogenesis;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001706,biological_process endoderm formation;GO:0001708,biological_process cell fate specification;GO:0001709,biological_process cell fate determination;GO:0001711,biological_process endodermal cell fate commitment;GO:0001764,biological_process neuron migration;GO:0001822,biological_process kidney development;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001840,biological_process neural plate development;GO:0001944,biological_process vasculature development;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0003266,biological_process regulation of secondary heart field cardioblast proliferation;GO:0003338,biological_process metanephros morphogenesis;GO:0003340,biological_process negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005719,cellular_component nuclear euchromatin;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005916,cellular_component fascia adherens;GO:0005923,cellular_component bicellular tight junction;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007165,biological_process signal transduction;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0007398,biological_process ectoderm development;GO:0007399,biological_process nervous system development;GO:0007403,biological_process glial cell fate determination;GO:0007507,biological_process heart development;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009948,biological_process anterior/posterior axis specification;GO:0009950,biological_process dorsal/ventral axis specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009954,biological_process proximal/distal pattern formation;GO:0009987,biological_process cellular process;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010909,biological_process positive regulation of heparan sulfate proteoglycan biosynthetic process;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016323,cellular_component basolateral plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016342,cellular_component catenin complex;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016600,cellular_component flotillin complex;GO:0019827,biological_process stem cell population maintenance;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0021819,biological_process layer formation in cerebral cortex;GO:0022009,biological_process central nervous system vasculogenesis;GO:0022405,biological_process hair cycle process;GO:0030018,cellular_component Z disc;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0030217,biological_process T cell differentiation;GO:0030316,biological_process osteoclast differentiation;GO:0030324,biological_process lung development;GO:0030331,molecular_function estrogen receptor binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030539,biological_process male genitalia development;GO:0030856,biological_process regulation of epithelial cell differentiation;GO:0030858,biological_process positive regulation of epithelial cell differentiation;GO:0030877,cellular_component beta-catenin destruction complex;GO:0030900,biological_process forebrain development;GO:0030901,biological_process midbrain development;GO:0030902,biological_process hindbrain development;GO:0030997,biological_process regulation of centriole-centriole cohesion;GO:0031016,biological_process pancreas development;GO:0031069,biological_process hair follicle morphogenesis;GO:0031253,cellular_component cell projection membrane;GO:0031528,cellular_component microvillus membrane;GO:0031641,biological_process regulation of myelination;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0032355,biological_process response to estradiol;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032993,cellular_component protein-DNA complex;GO:0033077,biological_process T cell differentiation in thymus;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0034332,biological_process adherens junction organization;GO:0034333,biological_process adherens junction assembly;GO:0034394,biological_process protein localization to cell surface;GO:0034613,biological_process cellular protein localization;GO:0034750,cellular_component Scrib-APC-beta-catenin complex;GO:0035050,biological_process embryonic heart tube development;GO:0035112,biological_process genitalia morphogenesis;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035315,biological_process hair cell differentiation;GO:0035411,biological_process catenin import into nucleus;GO:0035635,biological_process entry of bacterium into host cell;GO:0036023,biological_process embryonic skeletal limb joint morphogenesis;GO:0042127,biological_process regulation of cell proliferation;GO:0042129,biological_process regulation of T cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042493,biological_process response to drug;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0043296,cellular_component apical junction complex;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043588,biological_process skin development;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044325,molecular_function ion channel binding;GO:0044334,biological_process canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition;GO:0044336,biological_process canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0044798,cellular_component nuclear transcription factor complex;GO:0045177,cellular_component apical part of cell;GO:0045202,cellular_component synapse;GO:0045294,molecular_function alpha-catenin binding;GO:0045296,molecular_function cadherin binding;GO:0045453,biological_process bone resorption;GO:0045595,biological_process regulation of cell differentiation;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045603,biological_process positive regulation of endothelial cell differentiation;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045743,biological_process positive regulation of fibroblast growth factor receptor signaling pathway;GO:0045765,biological_process regulation of angiogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045976,biological_process negative regulation of mitotic cell cycle, embryonic;GO:0046332,molecular_function SMAD binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0048145,biological_process regulation of fibroblast proliferation;GO:0048469,biological_process cell maturation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048489,biological_process synaptic vesicle transport;GO:0048513,biological_process animal organ development;GO:0048538,biological_process thymus development;GO:0048599,biological_process oocyte development;GO:0048617,biological_process embryonic foregut morphogenesis;GO:0048643,biological_process positive regulation of skeletal muscle tissue development;GO:0048660,biological_process regulation of smooth muscle cell proliferation;GO:0048715,biological_process negative regulation of oligodendrocyte differentiation;GO:0050681,molecular_function androgen receptor binding;GO:0050767,biological_process regulation of neurogenesis;GO:0050808,biological_process synapse organization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051145,biological_process smooth muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0051884,biological_process regulation of anagen;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060066,biological_process oviduct development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060173,biological_process limb development;GO:0060439,biological_process trachea morphogenesis;GO:0060440,biological_process trachea formation;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060479,biological_process lung cell differentiation;GO:0060484,biological_process lung-associated mesenchyme development;GO:0060492,biological_process lung induction;GO:0060548,biological_process negative regulation of cell death;GO:0060742,biological_process epithelial cell differentiation involved in prostate gland development;GO:0060769,biological_process positive regulation of epithelial cell proliferation involved in prostate gland development;GO:0060789,biological_process hair follicle placode formation;GO:0060916,biological_process mesenchymal cell proliferation involved in lung development;GO:0061047,biological_process positive regulation of branching involved in lung morphogenesis;GO:0061154,biological_process endothelial tube morphogenesis;GO:0061198,biological_process fungiform papilla formation;GO:0061324,biological_process canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation;GO:0061549,biological_process sympathetic ganglion development;GO:0061550,biological_process cranial ganglion development;GO:0070062,cellular_component extracellular exosome;GO:0070369,cellular_component beta-catenin-TCF7L2 complex;GO:0070411,molecular_function I-SMAD binding;GO:0070491,molecular_function repressing transcription factor binding;GO:0070602,biological_process regulation of centromeric sister chromatid cohesion;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071664,cellular_component catenin-TCF7L2 complex;GO:0071681,biological_process cellular response to indole-3-methanol;GO:0071944,cellular_component cell periphery;GO:0072001,biological_process renal system development;GO:0072033,biological_process renal vesicle formation;GO:0072053,biological_process renal inner medulla development;GO:0072054,biological_process renal outer medulla development;GO:0072079,biological_process nephron tubule formation;GO:0072182,biological_process regulation of nephron tubule epithelial cell differentiation;GO:0090279,biological_process regulation of calcium ion import;GO:0097718,molecular_function disordered domain specific binding;GO:1901215,biological_process negative regulation of neuron death;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death;GO:1904501,biological_process positive regulation of chromatin-mediated maintenance of transcription;GO:1904793,biological_process regulation of euchromatin binding;GO:1904796,biological_process regulation of core promoter binding;GO:1904798,biological_process positive regulation of core promoter binding;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:1904888,biological_process cranial skeletal system development;GO:1904948,biological_process midbrain dopaminergic neuron differentiation;GO:1904954,biological_process canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;GO:1990403,biological_process embryonic brain development;GO:1990791,biological_process dorsal root ganglion development;GO:1990907,cellular_component beta-catenin-TCF complex;GO:1990909,cellular_component Wnt signalosome;GO:2000008,biological_process regulation of protein localization to cell surface;GO:2000017,biological_process positive regulation of determination of dorsal identity;GO:2000144,biological_process positive regulation of DNA-templated transcription, initiation;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	CTNNB1; catenin beta 1; K02105	catenin beta 1 [Source:HGNC Symbol%3BAcc:HGNC:2514]
ENSG00000178449	61.95	79.92	58.11	60.42	63.42	62.92	0.0958426302624823	3.47272576461203	0.450934574460743	0.794452805757191	12:50111978-50120457:+	COX14	5;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	COX14%2C cytochrome c oxidase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:28216]
ENSG00000176020	3.32	3.41	3.07	2.03	3.36	3.44	0.155544928177416	2.27498218490476	0.450955809986721	0.794452805757191	3:49716833-49719695:-	AMIGO3	5;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051965,biological_process positive regulation of synapse assembly	NA	adhesion molecule with Ig like domain 3 [Source:HGNC Symbol%3BAcc:HGNC:24075]
ENSG00000198865	15.29	12.79	15.26	16.51	13.74	16.61	-0.0925556511770106	3.54454148551447	0.451146723558737	0.794676355830085	5:42756800-42802360:+	CCDC152	NA	NA	coiled-coil domain containing 152 [Source:HGNC Symbol%3BAcc:HGNC:34438]
ENSG00000127452	12.54	14.13	15.31	13.24	13.08	13.81	0.0740199305384297	4.25006106055931	0.45148709024319	0.794958418183628	19:9810266-9827816:-	FBXL12	9;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 12 [Source:HGNC Symbol%3BAcc:HGNC:13611]
ENSG00000181982	12.72	13.12	12.59	13.70	13.79	12.99	-0.0649994548964205	4.47838364153566	0.451501825016085	0.794958418183628	4:24806116-24980204:-	CCDC149	NA	NA	coiled-coil domain containing 149 [Source:HGNC Symbol%3BAcc:HGNC:25405]
ENSG00000183793	5.65	4.60	6.98	4.97	4.32	6.48	0.146115363027247	3.05830688724795	0.451517018476905	0.794958418183628	16:15363623-15381047:-	NPIPA5	1;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex interacting protein family member A5 [Source:HGNC Symbol%3BAcc:HGNC:41980]
ENSG00000006194	14.57	14.68	15.22	15.41	15.90	15.33	-0.0563130124573287	4.96892007757952	0.451572572121226	0.794958418183628	16:3263799-3301401:+	ZNF263	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 263 [Source:HGNC Symbol%3BAcc:HGNC:13056]
ENSG00000138600	34.09	27.95	30.19	31.82	28.99	28.32	0.0653100020634988	5.61556568230758	0.451627065578905	0.794958418183628	15:50702265-50765808:-	SPPL2A	25;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0008233,molecular_function peptidase activity;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0031902,cellular_component late endosome membrane;GO:0033619,biological_process membrane protein proteolysis;GO:0042500,molecular_function aspartic endopeptidase activity, intramembrane cleaving;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050776,biological_process regulation of immune response;GO:0070062,cellular_component extracellular exosome;GO:0071458,cellular_component integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane	NA	signal peptide peptidase like 2A [Source:HGNC Symbol%3BAcc:HGNC:30227]
ENSG00000120137	23.03	22.99	19.96	23.20	24.53	21.98	-0.0694492394696016	4.65828816790524	0.451694519968643	0.794964423134945	5:168548494-168579600:-	PANK3	8;GO:0000166,molecular_function nucleotide binding;GO:0004594,molecular_function pantothenate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	pantothenate kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:19365]
ENSG00000092841	657.54	740.81	581.11	570.47	733.70	587.44	0.077033557310011	9.0519151433343	0.451955812755429	0.795311525904897	12:56158160-56163496:+	MYL6	16;GO:0003774,molecular_function motor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005903,cellular_component brush border;GO:0006936,biological_process muscle contraction;GO:0007519,biological_process skeletal muscle tissue development;GO:0008307,molecular_function structural constituent of muscle;GO:0016020,cellular_component membrane;GO:0016459,cellular_component myosin complex;GO:0016461,cellular_component unconventional myosin complex;GO:0030049,biological_process muscle filament sliding;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0031012,cellular_component extracellular matrix;GO:0031982,cellular_component vesicle;GO:0070062,cellular_component extracellular exosome	NA	myosin light chain 6 [Source:HGNC Symbol%3BAcc:HGNC:7587]
ENSG00000197576	26.12	23.89	29.67	29.56	27.89	27.10	-0.0675360227221067	4.72802241695357	0.45216018245422	0.795517590283282	7:27128506-27130799:-	HOXA4	9;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016604,cellular_component nuclear body;GO:0043565,molecular_function sequence-specific DNA binding	NA	homeobox A4 [Source:HGNC Symbol%3BAcc:HGNC:5105]
ENSG00000198720	4.21	4.11	4.27	3.53	4.01	4.26	0.104887484378684	3.00083288098157	0.452201088942144	0.795517590283282	17:29589768-29614761:+	ANKRD13B	7;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	ankyrin repeat domain 13B [Source:HGNC Symbol%3BAcc:HGNC:26363]
ENSG00000116701	0.90	0.30	0.98	0.52	0.77	0.49	0.35654530416364	0.281173516061992	0.452348674638874	0.795652956415702	1:183555562-183590876:-	NCF2	24;GO:0001669,cellular_component acrosomal vesicle;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006801,biological_process superoxide metabolic process;GO:0006909,biological_process phagocytosis;GO:0006968,biological_process cellular defense response;GO:0008022,molecular_function protein C-terminus binding;GO:0009055,molecular_function electron carrier activity;GO:0016175,molecular_function superoxide-generating NADPH oxidase activity;GO:0016176,molecular_function superoxide-generating NADPH oxidase activator activity;GO:0032010,cellular_component phagolysosome;GO:0034599,biological_process cellular response to oxidative stress;GO:0042554,biological_process superoxide anion generation;GO:0043020,cellular_component NADPH oxidase complex;GO:0043085,biological_process positive regulation of catalytic activity;GO:0045087,biological_process innate immune response;GO:0045454,biological_process cell redox homeostasis;GO:0045730,biological_process respiratory burst;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0055114,biological_process oxidation-reduction process	NCF2, P67PHOX; neutrophil cytosolic factor 2; K08010	neutrophil cytosolic factor 2 [Source:HGNC Symbol%3BAcc:HGNC:7661]
ENSG00000138468	9.11	7.47	8.41	8.14	8.52	7.37	0.0754063838985725	4.764798842876	0.452410994930567	0.795652956415702	3:101324204-101513241:-	SENP7	10;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity	NA	SUMO1/sentrin specific peptidase 7 [Source:HGNC Symbol%3BAcc:HGNC:30402]
ENSG00000186132	22.17	14.80	15.99	21.25	17.78	19.36	-0.116728134750008	3.14523501553761	0.452560134895803	0.795652956415702	2:119302224-119366828:-	C2orf76	NA	NA	chromosome 2 open reading frame 76 [Source:HGNC Symbol%3BAcc:HGNC:27017]
ENSG00000102871	13.58	13.99	13.37	14.40	13.77	15.48	-0.0848572971737375	3.73985904165851	0.45258382559721	0.795652956415702	16:67154179-67160298:-	TRADD	35;GO:0004871,molecular_function signal transducer activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0019900,molecular_function kinase binding;GO:0031264,cellular_component death-inducing signaling complex;GO:0032403,molecular_function protein complex binding;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043235,cellular_component receptor complex;GO:0045121,cellular_component membrane raft;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051291,biological_process protein heterooligomerization;GO:0051798,biological_process positive regulation of hair follicle development;GO:0060090,molecular_function binding, bridging;GO:0060544,biological_process regulation of necroptotic process;GO:0070513,molecular_function death domain binding;GO:0071550,biological_process death-inducing signaling complex assembly;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein; K03171	TNFRSF1A associated via death domain [Source:HGNC Symbol%3BAcc:HGNC:12030]
ENSG00000175832	0.83	0.39	0.86	0.57	0.68	0.44	0.368053571382787	0.106050037247898	0.452598527773405	0.795652956415702	17:43527843-43579620:-	ETV4	15;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	ETV4; ets translocation variant 4; K15592	ETS variant 4 [Source:HGNC Symbol%3BAcc:HGNC:3493]
ENSG00000142327	25.59	26.23	25.35	25.78	24.58	24.80	0.0484069993839599	5.79130695309451	0.452832700412464	0.795928000047888	2:240565803-240581372:+	RNPEPL1	11;GO:0004177,molecular_function aminopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity	NA	arginyl aminopeptidase like 1 [Source:HGNC Symbol%3BAcc:HGNC:10079]
ENSG00000037897	6.75	7.33	8.52	8.13	8.78	7.80	-0.114599857559868	2.77396908242728	0.452883224388805	0.795928000047888	12:57768470-57772793:-	METTL1	15;GO:0000049,molecular_function tRNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008176,molecular_function tRNA (guanine-N7-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0043527,cellular_component tRNA methyltransferase complex;GO:0106004,biological_process tRNA (guanine-N7)-methylation	NA	methyltransferase like 1 [Source:HGNC Symbol%3BAcc:HGNC:7030]
ENSG00000086504	59.40	62.03	62.87	59.36	68.19	65.31	-0.0544158704830872	5.84579204570193	0.453142083310884	0.796270198207532	16:367383-370527:-	MRPL28	13;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28; K02902	mitochondrial ribosomal protein L28 [Source:HGNC Symbol%3BAcc:HGNC:14484]
ENSG00000197798	20.30	18.77	17.95	21.52	22.02	17.35	-0.0799108489656881	4.38399479174983	0.453441882705041	0.796559670943669	11:126211413-126262986:+	FAM118B	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0015030,cellular_component Cajal body;GO:0030576,biological_process Cajal body organization	NA	family with sequence similarity 118 member B [Source:HGNC Symbol%3BAcc:HGNC:26110]
ENSG00000105855	28.87	30.74	26.77	28.56	33.43	28.74	-0.0611568453740879	6.09251619891852	0.453542782678893	0.796559670943669	7:20330701-20415754:+	ITGB8	18;GO:0001573,biological_process ganglioside metabolic process;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0034686,cellular_component integrin alphav-beta8 complex;GO:0051216,biological_process cartilage development;GO:0060674,biological_process placenta blood vessel development;GO:0070062,cellular_component extracellular exosome;GO:1990430,molecular_function extracellular matrix protein binding	ITGB8; integrin beta 8; K06591	integrin subunit beta 8 [Source:HGNC Symbol%3BAcc:HGNC:6163]
ENSG00000188643	300.10	289.79	288.93	317.42	294.78	304.48	-0.0487150431579548	6.53448991668271	0.45361543608406	0.796559670943669	1:153606885-153613145:-	S100A16	13;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0051592,biological_process response to calcium ion;GO:0070062,cellular_component extracellular exosome	NA	S100 calcium binding protein A16 [Source:HGNC Symbol%3BAcc:HGNC:20441]
ENSG00000134308	412.42	454.81	417.27	441.18	464.55	433.58	-0.0491247448404397	8.32965764858454	0.45362609299105	0.796559670943669	2:9583971-9631014:-	YWHAQ	21;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006605,biological_process protein targeting;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0021762,biological_process substantia nigra development;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0034766,biological_process negative regulation of ion transmembrane transport;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0071889,molecular_function 14-3-3 protein binding;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	NA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [Source:HGNC Symbol%3BAcc:HGNC:12854]
ENSG00000100664	109.79	111.90	112.65	116.22	117.96	113.72	-0.0456568022026549	7.20227653381617	0.453663371277771	0.796559670943669	14:103333543-103345025:+	EIF5	17;GO:0000166,molecular_function nucleotide binding;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0045296,molecular_function cadherin binding;GO:0071074,molecular_function eukaryotic initiation factor eIF2 binding;GO:0090630,biological_process activation of GTPase activity	EIF5; translation initiation factor 5; K03262	eukaryotic translation initiation factor 5 [Source:HGNC Symbol%3BAcc:HGNC:3299]
ENSG00000130695	11.28	11.04	10.62	10.48	10.48	10.86	0.0606975363455394	4.63423783216281	0.453691845127829	0.796559670943669	1:26234152-26279038:+	CEP85	14;GO:0000242,cellular_component pericentriolar material;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007059,biological_process chromosome segregation;GO:0046602,biological_process regulation of mitotic centrosome separation	NA	centrosomal protein 85 [Source:HGNC Symbol%3BAcc:HGNC:25309]
ENSG00000163565	96.64	89.28	101.76	98.72	95.55	106.48	-0.0514777418565086	7.87266104521166	0.454035270816716	0.797049896287356	1:158999967-159055155:+	IFI16	45;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001819,biological_process positive regulation of cytokine production;GO:0002218,biological_process activation of innate immune response;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030097,biological_process hemopoiesis;GO:0030099,biological_process myeloid cell differentiation;GO:0030224,biological_process monocyte differentiation;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032731,biological_process positive regulation of interleukin-1 beta production;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042149,biological_process cellular response to glucose starvation;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043392,biological_process negative regulation of DNA binding;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045824,biological_process negative regulation of innate immune response;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051607,biological_process defense response to virus;GO:0071479,biological_process cellular response to ionizing radiation;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:2000117,biological_process negative regulation of cysteine-type endopeptidase activity	NA	interferon gamma inducible protein 16 [Source:HGNC Symbol%3BAcc:HGNC:5395]
ENSG00000153989	36.72	35.88	37.60	36.63	39.52	39.44	-0.0558066747175461	5.05624501974879	0.454243509022627	0.797302697609993	6:117675501-117710640:+	NUS1	19;GO:0001525,biological_process angiogenesis;GO:0003674,molecular_function molecular_function;GO:0004659,molecular_function prenyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006489,biological_process dolichyl diphosphate biosynthetic process;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016765,molecular_function transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0019408,biological_process dolichol biosynthetic process;GO:0030154,biological_process cell differentiation;GO:0032383,biological_process regulation of intracellular cholesterol transport;GO:0035268,biological_process protein mannosylation;GO:0042632,biological_process cholesterol homeostasis;GO:0055092,biological_process sterol homeostasis	NA	NUS1 dehydrodolichyl diphosphate synthase subunit [Source:HGNC Symbol%3BAcc:HGNC:21042]
ENSG00000204256	87.20	80.46	90.01	91.44	86.46	90.73	-0.047596950899747	8.13847649914226	0.454469665410049	0.797320145953922	6:32968659-32981505:+	BRD2	12;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0016569,biological_process covalent chromatin modification;GO:0070577,molecular_function lysine-acetylated histone binding	NA	bromodomain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:1103]
ENSG00000115825	17.62	16.66	16.02	18.08	16.60	17.98	-0.0537616686513945	5.56231903881629	0.454470227779898	0.797320145953922	2:37250501-37324808:-	PRKD3	20;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:0089700,biological_process protein kinase D signaling	PKD; protein kinase D [EC:2.7.11.13]; K06070	protein kinase D3 [Source:HGNC Symbol%3BAcc:HGNC:9408]
ENSG00000099308	4.33	3.43	3.32	4.04	3.34	3.03	0.108060348003467	3.83231223476149	0.454538520580137	0.797320145953922	19:18097792-18151692:+	MAST3	14;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0006468,biological_process protein phosphorylation;GO:0007010,biological_process cytoskeleton organization;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction	NA	microtubule associated serine/threonine kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:19036]
ENSG00000103642	16.34	16.65	14.16	16.73	16.12	16.83	-0.0677260964970294	4.73617269216814	0.454561579921689	0.797320145953922	15:63121799-63142061:+	LACTB	7;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0019216,biological_process regulation of lipid metabolic process	NA	lactamase beta [Source:HGNC Symbol%3BAcc:HGNC:16468]
ENSG00000118162	4.10	5.11	4.22	4.29	5.62	4.78	-0.129961635457713	2.64697318188821	0.454629371306	0.797320145953922	19:47475143-47484268:-	KPTN	17;GO:0003779,molecular_function actin binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0007015,biological_process actin filament organization;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030027,cellular_component lamellipodium;GO:0031941,cellular_component filamentous actin;GO:0032420,cellular_component stereocilium;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042149,biological_process cellular response to glucose starvation;GO:0042995,cellular_component cell projection;GO:0051015,molecular_function actin filament binding;GO:0061462,biological_process protein localization to lysosome;GO:0098871,cellular_component postsynaptic actin cytoskeleton;GO:0140007,cellular_component KICSTOR complex;GO:1904262,biological_process negative regulation of TORC1 signaling	NA	kaptin%2C actin binding protein [Source:HGNC Symbol%3BAcc:HGNC:6404]
ENSG00000158435	71.64	65.45	64.16	64.68	63.60	67.66	0.0510183834963222	6.67134124098686	0.454663454659893	0.797320145953922	2:101252801-101270316:+	CNOT11	13;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0008283,biological_process cell proliferation;GO:0030014,cellular_component CCR4-NOT complex;GO:0031047,biological_process gene silencing by RNA	NA	CCR4-NOT transcription complex subunit 11 [Source:HGNC Symbol%3BAcc:HGNC:25217]
ENSG00000144460	0.47	0.29	0.60	0.27	0.66	0.83	-0.322924536525134	0.25067956355615	0.45483534271246	0.797320145953922	2:225399709-225654018:+	NYAP2	4;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0048812,biological_process neuron projection morphogenesis	NA	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 [Source:HGNC Symbol%3BAcc:HGNC:29291]
ENSG00000080824	347.75	428.96	334.11	328.59	401.74	333.20	0.0744703149264413	9.85987110033535	0.454925571677334	0.797320145953922	14:102080737-102139699:-	HSP90AA1	65;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006839,biological_process mitochondrial transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006950,biological_process response to stress;GO:0006986,biological_process response to unfolded protein;GO:0007004,biological_process telomere maintenance via telomerase;GO:0007165,biological_process signal transduction;GO:0009408,biological_process response to heat;GO:0009409,biological_process response to cold;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030235,molecular_function nitric-oxide synthase regulator activity;GO:0030911,molecular_function TPR domain binding;GO:0031396,biological_process regulation of protein ubiquitination;GO:0032587,cellular_component ruffle membrane;GO:0034774,cellular_component secretory granule lumen;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042026,biological_process protein refolding;GO:0042470,cellular_component melanosome;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043202,cellular_component lysosomal lumen;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043254,biological_process regulation of protein complex assembly;GO:0043312,biological_process neutrophil degranulation;GO:0043335,biological_process protein unfolding;GO:0045040,biological_process protein import into mitochondrial outer membrane;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0046677,biological_process response to antibiotic;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0050821,biological_process protein stabilization;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051020,molecular_function GTPase binding;GO:0051082,molecular_function unfolded protein binding;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051973,biological_process positive regulation of telomerase activity;GO:0061684,biological_process chaperone-mediated autophagy;GO:0070062,cellular_component extracellular exosome;GO:0070182,molecular_function DNA polymerase binding;GO:0071682,cellular_component endocytic vesicle lumen;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0097718,molecular_function disordered domain specific binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1905323,biological_process telomerase holoenzyme complex assembly;GO:1990782,molecular_function protein tyrosine kinase binding	HSP90A, htpG; molecular chaperone HtpG; K04079	heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol%3BAcc:HGNC:5253]
ENSG00000119698	5.76	5.90	5.84	7.09	5.54	6.02	-0.0819003277767182	4.05036836423031	0.454982782884299	0.797320145953922	14:94146127-94279735:+	PPP4R4	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008287,cellular_component protein serine/threonine phosphatase complex;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0080163,biological_process regulation of protein serine/threonine phosphatase activity	NA	protein phosphatase 4 regulatory subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:23788]
ENSG00000125458	47.41	40.49	51.13	43.27	41.35	48.85	0.0758795196895081	4.87801731657205	0.454996997533965	0.797320145953922	17:75130224-75131795:-	NT5C	18;GO:0000166,molecular_function nucleotide binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006195,biological_process purine nucleotide catabolic process;GO:0008252,molecular_function nucleotidase activity;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0009117,biological_process nucleotide metabolic process;GO:0009223,biological_process pyrimidine deoxyribonucleotide catabolic process;GO:0009264,biological_process deoxyribonucleotide catabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019103,molecular_function pyrimidine nucleotide binding;GO:0046135,biological_process pyrimidine nucleoside catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]; K01081	5'%2C 3'-nucleotidase%2C cytosolic [Source:HGNC Symbol%3BAcc:HGNC:17144]
ENSG00000127125	48.19	45.19	43.78	49.52	44.72	49.52	-0.055566044888331	5.49679391371159	0.455008131244677	0.797320145953922	1:42456116-42473385:+	PPCS	6;GO:0004632,molecular_function phosphopantothenate--cysteine ligase activity;GO:0005829,cellular_component cytosol;GO:0009108,biological_process coenzyme biosynthetic process;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016874,molecular_function ligase activity;GO:0070062,cellular_component extracellular exosome	PPCS, COAB; phosphopantothenate---cysteine ligase (ATP) [EC:6.3.2.51]; K01922	phosphopantothenoylcysteine synthetase [Source:HGNC Symbol%3BAcc:HGNC:25686]
ENSG00000141698	55.44	56.16	48.57	56.86	53.32	57.43	-0.0561301747097173	5.95829039057267	0.4550242418382	0.797320145953922	17:41825180-41836263:-	NT5C3B	11;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0009117,biological_process nucleotide metabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046872,molecular_function metal ion binding	E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]; K01081	5'-nucleotidase%2C cytosolic IIIB [Source:HGNC Symbol%3BAcc:HGNC:28300]
ENSG00000135093	5.45	5.16	5.77	5.00	5.36	5.06	0.10358061443224	3.07211587250195	0.455239648799393	0.797502558054007	12:109023088-109088026:+	USP30	17;GO:0000422,biological_process mitophagy;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008053,biological_process mitochondrial fusion;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0044313,biological_process protein K6-linked deubiquitination	USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]; K11851	ubiquitin specific peptidase 30 [Source:HGNC Symbol%3BAcc:HGNC:20065]
ENSG00000156928	42.76	44.52	45.61	46.40	39.97	41.87	0.0623261642795989	4.94041592407311	0.455261261387672	0.797502558054007	7:23298738-23311729:+	MALSU1	8;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043023,molecular_function ribosomal large subunit binding;GO:0070130,biological_process negative regulation of mitochondrial translation;GO:0090071,biological_process negative regulation of ribosome biogenesis	NA	mitochondrial assembly of ribosomal large subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:21721]
ENSG00000167264	15.85	13.05	13.49	15.14	14.82	15.02	-0.067157482964425	4.44337506696948	0.455321085066362	0.797502558054007	16:67987745-68079320:+	DUS2	17;GO:0002943,biological_process tRNA dihydrouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008033,biological_process tRNA processing;GO:0016491,molecular_function oxidoreductase activity;GO:0017150,molecular_function tRNA dihydrouridine synthase activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0060548,biological_process negative regulation of cell death	NA	dihydrouridine synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:26014]
ENSG00000168092	37.44	34.41	34.51	38.88	35.71	37.00	-0.0551680813508363	5.20677782856827	0.455543812714258	0.797780099777382	11:117144266-117176894:+	PAFAH1B2	22;GO:0001650,cellular_component fibrillar center;GO:0003847,molecular_function 1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007283,biological_process spermatogenesis;GO:0007420,biological_process brain development;GO:0016042,biological_process lipid catabolic process;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0034774,cellular_component secretory granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0046982,molecular_function protein heterodimerization activity;GO:0047179,molecular_function platelet-activating factor acetyltransferase activity;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	PAFAH1B2_3; platelet-activating factor acetylhydrolase IB subunit beta/gamma [EC:3.1.1.47]; K16795	platelet activating factor acetylhydrolase 1b catalytic subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:8575]
ENSG00000133422	22.00	22.99	24.79	24.62	22.63	25.83	-0.0550308410599163	6.21806643659253	0.455838086467189	0.798182842053494	22:30925129-30968298:-	MORC2	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	MORC family CW-type zinc finger 2 [Source:HGNC Symbol%3BAcc:HGNC:23573]
ENSG00000180329	21.02	22.55	22.20	19.77	21.55	21.59	0.071911086952458	4.01241302272787	0.455968809909673	0.798299130805186	17:44673068-44689779:-	CCDC43	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 43 [Source:HGNC Symbol%3BAcc:HGNC:26472]
ENSG00000154734	15.91	18.37	14.73	14.64	17.82	14.43	0.0723746074693737	5.58140205822038	0.456037056902973	0.798306019931829	21:26835746-26845409:-	ADAMTS1	20;GO:0001542,biological_process ovulation from ovarian follicle;GO:0001822,biological_process kidney development;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0046872,molecular_function metal ion binding;GO:0060347,biological_process heart trabecula formation	NA	ADAM metallopeptidase with thrombospondin type 1 motif 1 [Source:HGNC Symbol%3BAcc:HGNC:217]
ENSG00000138942	36.35	33.67	37.88	34.15	35.59	34.54	0.0659649955901278	4.60760430204598	0.456212621711758	0.798414713650996	22:31160182-31207019:+	RNF185	22;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0044390,molecular_function ubiquitin-like protein conjugating enzyme binding;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0055085,biological_process transmembrane transport;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904380,biological_process endoplasmic reticulum mannose trimming	RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27]; K10666	ring finger protein 185 [Source:HGNC Symbol%3BAcc:HGNC:26783]
ENSG00000183747	1.89	2.83	1.80	1.66	4.57	1.68	-0.275199409943148	2.11388929525178	0.456227790536254	0.798414713650996	16:20451460-20487667:+	ACSM2A	18;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003996,molecular_function acyl-CoA ligase activity;GO:0004321,molecular_function fatty-acyl-CoA synthase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0015645,molecular_function fatty acid ligase activity;GO:0016874,molecular_function ligase activity;GO:0036112,biological_process medium-chain fatty-acyl-CoA metabolic process;GO:0042593,biological_process glucose homeostasis;GO:0046872,molecular_function metal ion binding;GO:0047760,molecular_function butyrate-CoA ligase activity;GO:0070328,biological_process triglyceride homeostasis	ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]; K01896	acyl-CoA synthetase medium chain family member 2A [Source:HGNC Symbol%3BAcc:HGNC:32017]
ENSG00000087266	58.93	59.52	68.12	65.33	63.09	66.81	-0.0530398532193918	6.98474911150756	0.456326378053908	0.798419899064766	4:2793022-2841098:+	SH3BP2	6;GO:0001784,molecular_function phosphotyrosine binding;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0007165,biological_process signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0017124,molecular_function SH3 domain binding	SH3BP2; SH3-domain binding protein 2; K07984	SH3 domain binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:10825]
ENSG00000198858	42.64	34.02	44.43	38.30	36.17	41.80	0.0762841071047241	5.1133780948328	0.456359396106059	0.798419899064766	19:896502-913245:-	R3HDM4	2;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus	NA	R3H domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:28270]
ENSG00000135185	75.36	69.12	76.69	67.97	74.25	72.38	0.0594823810809297	5.12306030826673	0.456851525913994	0.799108066608929	7:87196159-87220587:-	TMEM243	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 243 [Source:HGNC Symbol%3BAcc:HGNC:21707]
ENSG00000104412	81.21	72.85	75.10	82.25	80.63	76.64	-0.049574663005315	6.19381930903595	0.456881491075773	0.799108066608929	8:108443600-108486918:+	EMC2	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:28963]
ENSG00000162545	132.50	102.10	118.89	127.03	130.62	118.10	-0.0677408479996699	4.84273977160844	0.457052574019596	0.799294674740102	1:20482390-20486220:-	CAMK2N1	13;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008427,molecular_function calcium-dependent protein kinase inhibitor activity;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	calcium/calmodulin dependent protein kinase II inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:24190]
ENSG00000111897	110.85	102.39	112.92	102.53	104.19	111.25	0.0495900838592106	7.19174451240616	0.457385415339741	0.799688891275345	6:122443353-122471822:-	SERINC1	18;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006658,biological_process phosphatidylserine metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015825,biological_process L-serine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0030674,molecular_function protein binding, bridging;GO:0044091,biological_process membrane biogenesis;GO:0070062,cellular_component extracellular exosome;GO:1904219,biological_process positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:1904222,biological_process positive regulation of serine C-palmitoyltransferase activity	NA	serine incorporator 1 [Source:HGNC Symbol%3BAcc:HGNC:13464]
ENSG00000134107	203.02	180.54	205.56	211.35	187.52	218.58	-0.0552368033997574	7.95969993992871	0.457445484251977	0.799688891275345	3:4979115-4985323:+	BHLHE40	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001191,molecular_function transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007623,biological_process circadian rhythm;GO:0009416,biological_process response to light stimulus;GO:0016604,cellular_component nuclear body;GO:0019904,molecular_function protein domain specific binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0042803,molecular_function protein homodimerization activity;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043426,molecular_function MRF binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0070888,molecular_function E-box binding	BHLHB2, DEC1; class B basic helix-loop-helix protein 2; K03729	basic helix-loop-helix family member e40 [Source:HGNC Symbol%3BAcc:HGNC:1046]
ENSG00000122547	6.74	7.45	6.73	7.85	7.33	7.13	-0.0871785998693904	3.63647807250612	0.457471265362622	0.799688891275345	7:36153148-36301543:+	EEPD1	2;GO:0003677,molecular_function DNA binding;GO:0006281,biological_process DNA repair	NA	endonuclease/exonuclease/phosphatase family domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:22223]
ENSG00000157470	4.54	3.40	2.62	3.90	4.41	3.60	-0.154604677215814	2.1641183391471	0.457549533685397	0.799713089501104	15:59372692-59523549:+	FAM81A	NA	NA	family with sequence similarity 81 member A [Source:HGNC Symbol%3BAcc:HGNC:28379]
ENSG00000130449	4.30	4.30	4.77	4.27	4.14	4.40	0.0745559486769698	4.00646391810255	0.457902626391135	0.800114822755273	5:61332272-61546170:+	ZSWIM6	2;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger SWIM-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:29316]
ENSG00000164114	4.04	5.23	4.39	5.09	5.39	4.30	-0.111594761841187	3.28119222652415	0.457999716277758	0.800114822755273	4:155342657-155376970:-	MAP9	20;GO:0000235,cellular_component astral microtubule;GO:0000910,biological_process cytokinesis;GO:0005737,cellular_component cytoplasm;GO:0005818,cellular_component aster;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0046602,biological_process regulation of mitotic centrosome separation;GO:0051225,biological_process spindle assembly;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0072686,cellular_component mitotic spindle;GO:0090307,biological_process mitotic spindle assembly;GO:1902412,biological_process regulation of mitotic cytokinesis;GO:1990023,cellular_component mitotic spindle midzone	NA	microtubule associated protein 9 [Source:HGNC Symbol%3BAcc:HGNC:26118]
ENSG00000107833	48.67	52.97	50.17	54.68	54.25	50.57	-0.0627049155260146	4.79953110292376	0.458019151538601	0.800114822755273	10:101781324-101783413:-	NPM3	8;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0009303,biological_process rRNA transcription;GO:0015629,cellular_component actin cytoskeleton	NA	nucleophosmin/nucleoplasmin 3 [Source:HGNC Symbol%3BAcc:HGNC:7931]
ENSG00000070831	326.27	332.31	321.61	318.66	321.41	318.67	0.0433609669838972	7.73846663770705	0.458037213445498	0.800114822755273	1:22052626-22092946:+	CDC42	130;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000322,cellular_component storage vacuole;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002040,biological_process sprouting angiogenesis;GO:0003161,biological_process cardiac conduction system development;GO:0003334,biological_process keratinocyte development;GO:0003924,molecular_function GTPase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0007015,biological_process actin filament organization;GO:0007030,biological_process Golgi organization;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0007097,biological_process nuclear migration;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007399,biological_process nervous system development;GO:0007596,biological_process blood coagulation;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016567,biological_process protein ubiquitination;GO:0017119,cellular_component Golgi transport complex;GO:0019901,molecular_function protein kinase binding;GO:0021762,biological_process substantia nigra development;GO:0030036,biological_process actin cytoskeleton organization;GO:0030141,cellular_component secretory granule;GO:0030154,biological_process cell differentiation;GO:0030175,cellular_component filopodium;GO:0030225,biological_process macrophage differentiation;GO:0030307,biological_process positive regulation of cell growth;GO:0030496,cellular_component midbody;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031069,biological_process hair follicle morphogenesis;GO:0031256,cellular_component leading edge membrane;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0031295,biological_process T cell costimulation;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031424,biological_process keratinization;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0031647,biological_process regulation of protein stability;GO:0031996,molecular_function thioesterase binding;GO:0032427,molecular_function GBD domain binding;GO:0032467,biological_process positive regulation of cytokinesis;GO:0032488,biological_process Cdc42 protein signal transduction;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034191,molecular_function apolipoprotein A-I receptor binding;GO:0034332,biological_process adherens junction organization;GO:0034613,biological_process cellular protein localization;GO:0035088,biological_process establishment or maintenance of apical/basal cell polarity;GO:0035264,biological_process multicellular organism growth;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0036336,biological_process dendritic cell migration;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0039694,biological_process viral RNA genome replication;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042176,biological_process regulation of protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043197,cellular_component dendritic spine;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045177,cellular_component apical part of cell;GO:0045740,biological_process positive regulation of DNA replication;GO:0045859,biological_process regulation of protein kinase activity;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046847,biological_process filopodium assembly;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048664,biological_process neuron fate determination;GO:0048730,biological_process epidermis morphogenesis;GO:0051017,biological_process actin filament bundle assembly;GO:0051022,molecular_function Rho GDP-dissociation inhibitor binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051233,cellular_component spindle midzone;GO:0051246,biological_process regulation of protein metabolic process;GO:0051301,biological_process cell division;GO:0051489,biological_process regulation of filopodium assembly;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051647,biological_process nucleus localization;GO:0051683,biological_process establishment of Golgi localization;GO:0051835,biological_process positive regulation of synapse structural plasticity;GO:0051988,biological_process regulation of attachment of spindle microtubules to kinetochore;GO:0060047,biological_process heart contraction;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060501,biological_process positive regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0060661,biological_process submandibular salivary gland formation;GO:0060684,biological_process epithelial-mesenchymal cell signaling;GO:0060789,biological_process hair follicle placode formation;GO:0060997,biological_process dendritic spine morphogenesis;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0071338,biological_process positive regulation of hair follicle cell proliferation;GO:0071944,cellular_component cell periphery;GO:0072384,biological_process organelle transport along microtubule;GO:0072686,cellular_component mitotic spindle;GO:0090135,biological_process actin filament branching;GO:0090136,biological_process epithelial cell-cell adhesion;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0099563,biological_process modification of synaptic structure;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	CDC42; cell division control protein 42; K04393	cell division cycle 42 [Source:HGNC Symbol%3BAcc:HGNC:1736]
ENSG00000168005	24.09	24.87	25.99	24.16	24.05	24.43	0.0564137952959618	4.9487805769987	0.458154484641399	0.800207065970689	11:63813387-63827718:+	C11orf84	NA	NA	chromosome 11 open reading frame 84 [Source:HGNC Symbol%3BAcc:HGNC:25115]
ENSG00000162373	3.19	2.12	2.86	2.19	2.28	2.90	0.17569138813674	1.78832248964368	0.458244632863521	0.80025191723901	1:48727522-48776969:-	BEND5	6;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	BEN domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:25668]
ENSG00000189410	4.43	4.70	4.39	4.19	4.01	4.36	0.111976751332777	2.55897083015227	0.458314368504186	0.800261113552181	1:20719731-20732837:-	SH2D5	6;GO:0005886,cellular_component plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	SH2 domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:28819]
ENSG00000174307	71.55	69.23	73.60	66.42	68.08	72.90	0.0607829630240673	4.75309920794968	0.458487571241659	0.800450945404038	1:201464382-201469237:-	PHLDA3	15;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0016020,cellular_component membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	pleckstrin homology like domain family A member 3 [Source:HGNC Symbol%3BAcc:HGNC:8934]
ENSG00000159592	73.41	72.51	73.45	79.03	74.35	75.11	-0.0468016050864737	6.73305527365531	0.458654702128151	0.800565604283752	1:45627303-45688113:-	GPBP1L1	6;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	GC-rich promoter binding protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:28843]
ENSG00000196419	270.21	289.57	263.47	285.47	294.24	277.50	-0.0469160888817006	9.0003831053941	0.458758207253782	0.800565604283752	22:41621118-41664048:+	XRCC6	59;GO:0000166,molecular_function nucleotide binding;GO:0000723,biological_process telomere maintenance;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007420,biological_process brain development;GO:0008022,molecular_function protein C-terminus binding;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016829,molecular_function lyase activity;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032508,biological_process DNA duplex unwinding;GO:0032993,cellular_component protein-DNA complex;GO:0034774,cellular_component secretory granule lumen;GO:0042162,molecular_function telomeric DNA binding;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043564,cellular_component Ku70:Ku80 complex;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044877,molecular_function macromolecular complex binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048660,biological_process regulation of smooth muscle cell proliferation;GO:0051290,biological_process protein heterotetramerization;GO:0051575,molecular_function 5'-deoxyribose-5-phosphate lyase activity;GO:0070419,cellular_component nonhomologous end joining complex;GO:0071475,biological_process cellular hyperosmotic salinity response;GO:0071480,biological_process cellular response to gamma radiation;GO:0071481,biological_process cellular response to X-ray;GO:0075713,biological_process establishment of integrated proviral latency;GO:0097680,biological_process double-strand break repair via classical nonhomologous end joining;GO:1904813,cellular_component ficolin-1-rich granule lumen	XRCC6, KU70, G22P1; ATP-dependent DNA helicase 2 subunit 1; K10884	X-ray repair cross complementing 6 [Source:HGNC Symbol%3BAcc:HGNC:4055]
ENSG00000177565	74.07	61.11	73.86	75.85	69.30	74.50	-0.0573580184196824	6.91245711609456	0.458839001839945	0.800565604283752	3:177019339-177228000:-	TBL1XR1	32;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002021,biological_process response to dietary excess;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005876,cellular_component spindle microtubule;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008013,molecular_function beta-catenin binding;GO:0010468,biological_process regulation of gene expression;GO:0016042,biological_process lipid catabolic process;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0017053,cellular_component transcriptional repressor complex;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030814,biological_process regulation of cAMP metabolic process;GO:0035264,biological_process multicellular organism growth;GO:0042393,molecular_function histone binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047485,molecular_function protein N-terminus binding;GO:0050872,biological_process white fat cell differentiation;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060612,biological_process adipose tissue development;GO:0060613,biological_process fat pad development;GO:0090207,biological_process regulation of triglyceride metabolic process	TBL1; transducin (beta)-like 1; K04508	transducin beta like 1 X-linked receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:29529]
ENSG00000155903	5.74	5.90	5.87	5.50	6.91	6.27	-0.0818116930588087	3.96279991632148	0.45884919322091	0.800565604283752	3:141487046-141615342:+	RASA2	13;GO:0000165,biological_process MAPK cascade;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0035556,biological_process intracellular signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	RASA2, GAP1M; Ras GTPase-activating protein 2; K08053	RAS p21 protein activator 2 [Source:HGNC Symbol%3BAcc:HGNC:9872]
ENSG00000049246	9.38	8.16	10.07	9.42	9.50	10.23	-0.0609934318156285	5.11312123534798	0.458875716948272	0.800565604283752	1:7784319-7845177:+	PER3	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007623,biological_process circadian rhythm;GO:0019900,molecular_function kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0045187,biological_process regulation of circadian sleep/wake cycle, sleep;GO:0048511,biological_process rhythmic process;GO:0050821,biological_process protein stabilization	PER2; period circadian protein 2; K02633	period circadian clock 3 [Source:HGNC Symbol%3BAcc:HGNC:8847]
ENSG00000167977	19.40	21.07	23.06	24.36	21.84	21.35	-0.076702174437668	4.19336632174791	0.459008082745351	0.80068399818972	16:2682474-2709030:+	KCTD5	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016032,biological_process viral process;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032403,molecular_function protein complex binding;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051260,biological_process protein homooligomerization;GO:0097602,molecular_function cullin family protein binding	NA	potassium channel tetramerization domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:21423]
ENSG00000154529	1.74	2.32	1.93	1.46	1.64	2.36	0.133831301354619	2.99351094343758	0.459212569193687	0.800892606985293	9:41890313-42129510:-	CNTNAP3B	3;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	contactin associated protein like 3B [Source:HGNC Symbol%3BAcc:HGNC:32035]
ENSG00000157045	35.24	37.71	34.58	36.47	38.00	38.03	-0.0576977405354353	5.09821885620203	0.459279095980534	0.800892606985293	16:15037852-15056079:-	NTAN1	6;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007613,biological_process memory;GO:0008344,biological_process adult locomotory behavior;GO:0008418,molecular_function protein-N-terminal asparagine amidohydrolase activity;GO:0016787,molecular_function hydrolase activity	NA	N-terminal asparagine amidase [Source:HGNC Symbol%3BAcc:HGNC:29909]
ENSG00000163932	19.29	20.12	22.14	23.78	20.57	20.49	-0.0624848885120834	5.42327368637111	0.459333586633712	0.800892606985293	3:53156008-53192717:+	PRKCD	83;GO:0000166,molecular_function nucleotide binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0004699,molecular_function calcium-independent protein kinase C activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007202,biological_process activation of phospholipase C activity;GO:0008047,molecular_function enzyme activator activity;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010469,biological_process regulation of receptor activity;GO:0016020,cellular_component membrane;GO:0016064,biological_process immunoglobulin mediated immune response;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016363,cellular_component nuclear matrix;GO:0016572,biological_process histone phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0023021,biological_process termination of signal transduction;GO:0030168,biological_process platelet activation;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0032079,biological_process positive regulation of endodeoxyribonuclease activity;GO:0032091,biological_process negative regulation of protein binding;GO:0032147,biological_process activation of protein kinase activity;GO:0032613,biological_process interleukin-10 production;GO:0032615,biological_process interleukin-12 production;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0034351,biological_process negative regulation of glial cell apoptotic process;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0035578,cellular_component azurophil granule lumen;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042100,biological_process B cell proliferation;GO:0042119,biological_process neutrophil activation;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042742,biological_process defense response to bacterium;GO:0043312,biological_process neutrophil degranulation;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043488,biological_process regulation of mRNA stability;GO:0043560,molecular_function insulin receptor substrate binding;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050732,biological_process negative regulation of peptidyl-tyrosine phosphorylation;GO:0050821,biological_process protein stabilization;GO:0051490,biological_process negative regulation of filopodium assembly;GO:0060326,biological_process cell chemotaxis;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071447,biological_process cellular response to hydroperoxide;GO:0090331,biological_process negative regulation of platelet aggregation;GO:0090398,biological_process cellular senescence;GO:0097194,biological_process execution phase of apoptosis;GO:1900163,biological_process positive regulation of phospholipid scramblase activity;GO:1904385,biological_process cellular response to angiotensin;GO:2000304,biological_process positive regulation of ceramide biosynthetic process;GO:2000753,biological_process positive regulation of glucosylceramide catabolic process;GO:2000755,biological_process positive regulation of sphingomyelin catabolic process;GO:2001022,biological_process positive regulation of response to DNA damage stimulus;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	PRKCD; novel protein kinase C delta type [EC:2.7.11.13]; K06068	protein kinase C delta [Source:HGNC Symbol%3BAcc:HGNC:9399]
ENSG00000006756	21.95	20.56	22.44	20.55	21.06	21.59	0.0543167391559833	5.32932167690541	0.459385753785168	0.800892606985293	X:2903969-2929351:-	ARSD	13;GO:0003824,molecular_function catalytic activity;GO:0004065,molecular_function arylsulfatase activity;GO:0005764,cellular_component lysosome;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	arylsulfatase D [Source:HGNC Symbol%3BAcc:HGNC:717]
ENSG00000214029	1.56	1.52	1.49	1.38	1.77	2.07	-0.18123588017567	1.49748443617344	0.45947987053851	0.8009441978647	12:133106816-133130473:-	ZNF891	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 891 [Source:HGNC Symbol%3BAcc:HGNC:38709]
ENSG00000122557	41.58	39.07	44.54	45.06	42.78	43.24	-0.0513337604136392	5.70761679135211	0.459624353925606	0.80108355873049	7:35632658-35695571:-	HERPUD2	4;GO:0006986,biological_process response to unfolded protein;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	HERPUD family member 2 [Source:HGNC Symbol%3BAcc:HGNC:21915]
ENSG00000145934	0.36	0.43	0.42	0.47	0.38	0.50	-0.156528722146413	1.90662895808295	0.45986744888139	0.801258052572598	5:167284798-168264157:+	TENM2	33;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000902,biological_process cell morphogenesis;GO:0005102,molecular_function receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016605,cellular_component PML body;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043197,cellular_component dendritic spine;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046982,molecular_function protein heterodimerization activity;GO:0048666,biological_process neuron development;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0097264,biological_process self proteolysis	NA	teneurin transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:29943]
ENSG00000205593	6.17	4.81	5.72	5.17	5.82	4.79	0.106219857851824	3.43897171385122	0.459910274721179	0.801258052572598	22:50309029-50327060:-	DENND6B	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization	NA	DENN domain containing 6B [Source:HGNC Symbol%3BAcc:HGNC:32690]
ENSG00000070371	16.82	11.11	15.05	16.87	12.36	17.25	-0.0991633100477529	6.25178589484614	0.459918120082152	0.801258052572598	22:19179472-19291716:-	CLTCL1	30;GO:0000278,biological_process mitotic cell cycle;GO:0004871,molecular_function signal transducer activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005770,cellular_component late endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005905,cellular_component clathrin-coated pit;GO:0006886,biological_process intracellular protein transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030130,cellular_component clathrin coat of trans-Golgi network vesicle;GO:0030132,cellular_component clathrin coat of coated pit;GO:0030135,cellular_component coated vesicle;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032051,molecular_function clathrin light chain binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0046326,biological_process positive regulation of glucose import;GO:0048268,biological_process clathrin coat assembly;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0071439,cellular_component clathrin complex;GO:0097443,cellular_component sorting endosome	CLTC; clathrin heavy chain; K04646	clathrin heavy chain like 1 [Source:HGNC Symbol%3BAcc:HGNC:2093]
ENSG00000119737	0.65	0.88	0.55	0.83	1.03	0.65	-0.278941710865974	0.466090152925285	0.460045520072261	0.801292458808042	2:53852912-53859989:-	GPR75	11;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016493,molecular_function C-C chemokine receptor activity;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:1901214,biological_process regulation of neuron death	NA	G protein-coupled receptor 75 [Source:HGNC Symbol%3BAcc:HGNC:4526]
ENSG00000112511	24.91	21.57	23.54	25.13	20.20	22.16	0.0684117040198899	5.29311345552821	0.460098234222216	0.801292458808042	6:33410398-33416453:+	PHF1	21;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016569,biological_process covalent chromatin modification;GO:0031060,biological_process regulation of histone methylation;GO:0035064,molecular_function methylated histone binding;GO:0035098,cellular_component ESC/E(Z) complex;GO:0035861,cellular_component site of double-strand break;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0061086,biological_process negative regulation of histone H3-K27 methylation;GO:0061087,biological_process positive regulation of histone H3-K27 methylation	NA	PHD finger protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8919]
ENSG00000008838	14.44	15.73	15.96	15.20	17.85	15.39	-0.0593330194773067	5.80476052597301	0.460137450527336	0.801292458808042	17:40019096-40061215:-	MED24	27;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016573,biological_process histone acetylation;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0051291,biological_process protein heterooligomerization;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1903506,biological_process regulation of nucleic acid-templated transcription	MED24; mediator of RNA polymerase II transcription subunit 24; K15167	mediator complex subunit 24 [Source:HGNC Symbol%3BAcc:HGNC:22963]
ENSG00000167881	47.35	50.55	48.83	48.72	45.88	48.37	0.0475893939860279	6.50774590201344	0.46019607982297	0.801292458808042	17:76038774-76072653:-	SRP68	20;GO:0003723,molecular_function RNA binding;GO:0005047,molecular_function signal recognition particle binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005786,cellular_component signal recognition particle, endoplasmic reticulum targeting;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008312,molecular_function 7S RNA binding;GO:0019904,molecular_function protein domain specific binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030942,molecular_function endoplasmic reticulum signal peptide binding;GO:0042493,biological_process response to drug;GO:0043022,molecular_function ribosome binding;GO:0045047,biological_process protein targeting to ER;GO:0048500,cellular_component signal recognition particle	SRP68; signal recognition particle subunit SRP68; K03107	signal recognition particle 68 [Source:HGNC Symbol%3BAcc:HGNC:11302]
ENSG00000258289	1.13	1.83	1.76	0.96	2.06	0.79	0.31333559172264	0.0379602893297779	0.460446181847441	0.801615491623041	14:64914360-64944591:+	CHURC1	6;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	churchill domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20099]
ENSG00000165410	80.21	85.46	77.86	83.54	90.53	80.99	-0.0574775685222193	5.38449153747385	0.4605121396312	0.801617892194936	14:34706768-34714823:-	CFL2	20;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization;GO:0007519,biological_process skeletal muscle tissue development;GO:0015629,cellular_component actin cytoskeleton;GO:0016363,cellular_component nuclear matrix;GO:0030018,cellular_component Z disc;GO:0030042,biological_process actin filament depolymerization;GO:0030043,biological_process actin filament fragmentation;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0031674,cellular_component I band;GO:0045214,biological_process sarcomere organization;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	CFL; cofilin; K05765	cofilin 2 [Source:HGNC Symbol%3BAcc:HGNC:1875]
ENSG00000102738	11.44	12.02	10.56	12.45	11.33	12.40	-0.0830483818939989	3.80876731713888	0.460592290199466	0.801644994145538	13:40729134-40771173:-	MRPS31	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0019904,molecular_function protein domain specific binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S31 [Source:HGNC Symbol%3BAcc:HGNC:16632]
ENSG00000008323	0.19	0.37	0.42	0.46	0.29	0.46	-0.313091594007907	0.14023617911297	0.460808118386029	0.801811426953726	12:6310435-6328506:+	PLEKHG6	13;GO:0000922,cellular_component spindle pole;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0032154,cellular_component cleavage furrow;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity	NA	pleckstrin homology and RhoGEF domain containing G6 [Source:HGNC Symbol%3BAcc:HGNC:25562]
ENSG00000078814	0.63	0.42	0.43	0.57	0.61	0.50	-0.159075149477526	1.77822718876253	0.460823426260697	0.801811426953726	20:34975402-35002437:+	MYH7B	9;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0016020,cellular_component membrane;GO:0016459,cellular_component myosin complex;GO:0032982,cellular_component myosin filament;GO:0097512,cellular_component cardiac myofibril	MYH; myosin heavy chain; K10352	myosin heavy chain 7B [Source:HGNC Symbol%3BAcc:HGNC:15906]
ENSG00000197894	243.01	254.87	233.98	247.82	265.35	248.90	-0.0471000906844458	8.12877333425146	0.46088383058668	0.801811426953726	4:99070977-99088801:-	ADH5	23;GO:0001523,biological_process retinoid metabolic process;GO:0003016,biological_process respiratory system process;GO:0004022,molecular_function alcohol dehydrogenase (NAD) activity;GO:0005504,molecular_function fatty acid binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006069,biological_process ethanol oxidation;GO:0008270,molecular_function zinc ion binding;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0018119,biological_process peptidyl-cysteine S-nitrosylation;GO:0018467,molecular_function formaldehyde dehydrogenase activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0042803,molecular_function protein homodimerization activity;GO:0045777,biological_process positive regulation of blood pressure;GO:0046294,biological_process formaldehyde catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051409,biological_process response to nitrosative stress;GO:0051775,biological_process response to redox state;GO:0051903,molecular_function S-(hydroxymethyl)glutathione dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]; K00121	alcohol dehydrogenase 5 (class III)%2C chi polypeptide [Source:HGNC Symbol%3BAcc:HGNC:253]
ENSG00000213780	22.93	20.62	21.45	20.42	21.78	20.80	0.0611742470793938	4.89530736074664	0.460946293622959	0.801811426953726	6:30908183-30914106:+	GTF2H4	36;GO:0000438,cellular_component core TFIIH complex portion of holo TFIIH complex;GO:0000439,cellular_component core TFIIH complex;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005675,cellular_component holo TFIIH complex;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0016607,cellular_component nuclear speck;GO:0032508,biological_process DNA duplex unwinding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0070816,biological_process phosphorylation of RNA polymerase II C-terminal domain;GO:0070911,biological_process global genome nucleotide-excision repair	NA	general transcription factor IIH subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:4658]
ENSG00000160145	3.72	4.13	4.00	3.81	4.75	3.96	-0.0682657436740777	5.2592150920562	0.461113032240488	0.801888096139149	3:124080022-124726325:+	KALRN	51;GO:0000166,molecular_function nucleotide binding;GO:0001662,biological_process behavioral fear response;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007399,biological_process nervous system development;GO:0007528,biological_process neuromuscular junction development;GO:0007595,biological_process lactation;GO:0007613,biological_process memory;GO:0008344,biological_process adult locomotory behavior;GO:0009612,biological_process response to mechanical stimulus;GO:0014069,cellular_component postsynaptic density;GO:0014909,biological_process smooth muscle cell migration;GO:0015629,cellular_component actin cytoskeleton;GO:0016192,biological_process vesicle-mediated transport;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035176,biological_process social behavior;GO:0035556,biological_process intracellular signal transduction;GO:0042711,biological_process maternal behavior;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0046959,biological_process habituation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048148,biological_process behavioral response to cocaine;GO:0048168,biological_process regulation of neuronal synaptic plasticity;GO:0048659,biological_process smooth muscle cell proliferation;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060125,biological_process negative regulation of growth hormone secretion;GO:0060137,biological_process maternal process involved in parturition;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0061368,biological_process behavioral response to formalin induced pain;GO:0070062,cellular_component extracellular exosome;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1903076,biological_process regulation of protein localization to plasma membrane	NA	kalirin RhoGEF kinase [Source:HGNC Symbol%3BAcc:HGNC:4814]
ENSG00000166801	38.53	40.41	37.74	37.37	42.16	42.35	-0.0530280280945039	6.19099978541903	0.461167226194197	0.801888096139149	11:59142747-59155039:+	FAM111A	9;GO:0000785,cellular_component chromatin;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0016032,biological_process viral process;GO:0045071,biological_process negative regulation of viral genome replication;GO:0051607,biological_process defense response to virus	NA	family with sequence similarity 111 member A [Source:HGNC Symbol%3BAcc:HGNC:24725]
ENSG00000145191	28.88	30.21	27.21	28.34	28.95	26.61	0.050581064914653	5.94296268967465	0.461184171299234	0.801888096139149	3:184135037-184145311:+	EIF2B5	28;GO:0001541,biological_process ovarian follicle development;GO:0003743,molecular_function translation initiation factor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005851,cellular_component eukaryotic translation initiation factor 2B complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0007568,biological_process aging;GO:0009408,biological_process response to heat;GO:0009749,biological_process response to glucose;GO:0010226,biological_process response to lithium ion;GO:0014002,biological_process astrocyte development;GO:0014003,biological_process oligodendrocyte development;GO:0021766,biological_process hippocampus development;GO:0031369,molecular_function translation initiation factor binding;GO:0032057,biological_process negative regulation of translational initiation in response to stress;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035690,biological_process cellular response to drug;GO:0042552,biological_process myelination;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045727,biological_process positive regulation of translation;GO:0045948,biological_process positive regulation of translational initiation;GO:0048708,biological_process astrocyte differentiation	EIF2B5; translation initiation factor eIF-2B subunit epsilon; K03240	eukaryotic translation initiation factor 2B subunit epsilon [Source:HGNC Symbol%3BAcc:HGNC:3261]
ENSG00000137497	53.22	50.63	52.63	51.36	50.64	51.21	0.0426314541911058	8.38568795439596	0.461254289835627	0.801897689037764	11:72002863-72080693:-	NUMA1	69;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000139,cellular_component Golgi membrane;GO:0000922,cellular_component spindle pole;GO:0001578,biological_process microtubule bundle formation;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006997,biological_process nucleus organization;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0008017,molecular_function microtubule binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008289,molecular_function lipid binding;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030425,cellular_component dendrite;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030953,biological_process astral microtubule organization;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031616,cellular_component spindle pole centrosome;GO:0032388,biological_process positive regulation of intracellular transport;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035371,cellular_component microtubule plus-end;GO:0036449,cellular_component microtubule minus-end;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0045177,cellular_component apical part of cell;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0051010,molecular_function microtubule plus-end binding;GO:0051011,molecular_function microtubule minus-end binding;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051798,biological_process positive regulation of hair follicle development;GO:0051984,biological_process positive regulation of chromosome segregation;GO:0055028,cellular_component cortical microtubule;GO:0055048,biological_process anastral spindle assembly;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0060487,biological_process lung epithelial cell differentiation;GO:0061673,cellular_component mitotic spindle astral microtubule;GO:0070062,cellular_component extracellular exosome;GO:0070840,molecular_function dynein complex binding;GO:0072686,cellular_component mitotic spindle;GO:0090235,biological_process regulation of metaphase plate congression;GO:0097427,cellular_component microtubule bundle;GO:0097431,cellular_component mitotic spindle pole;GO:0097718,molecular_function disordered domain specific binding;GO:0099738,cellular_component cell cortex region;GO:1902365,biological_process positive regulation of protein localization to spindle pole body;GO:1902846,biological_process positive regulation of mitotic spindle elongation;GO:1904778,biological_process positive regulation of protein localization to cell cortex;GO:1905720,cellular_component cytoplasmic microtubule bundle;GO:1905820,biological_process positive regulation of chromosome separation;GO:1905832,biological_process positive regulation of spindle assembly;GO:1990023,cellular_component mitotic spindle midzone	NA	nuclear mitotic apparatus protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8059]
ENSG00000174669	2.99	2.51	3.39	2.24	3.05	2.83	0.156597945108876	2.01835571324161	0.461410879483732	0.801928980764402	11:66362520-66372214:-	SLC29A2	14;GO:0005337,molecular_function nucleoside transmembrane transporter activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006810,biological_process transport;GO:0008283,biological_process cell proliferation;GO:0015858,biological_process nucleoside transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0031965,cellular_component nuclear membrane;GO:1901642,biological_process nucleoside transmembrane transport	SLC29A1_2_3, ENT1_2_3; solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3; K15014	solute carrier family 29 member 2 [Source:HGNC Symbol%3BAcc:HGNC:11004]
ENSG00000176731	174.66	162.61	161.69	175.41	164.20	181.93	-0.0512563276982283	5.7495230137759	0.461417700357275	0.801928980764402	8:85214075-85220421:-	C8orf59	NA	NA	chromosome 8 open reading frame 59 [Source:HGNC Symbol%3BAcc:HGNC:32235]
ENSG00000164597	23.34	23.22	24.15	22.42	21.45	24.87	0.0520331211660997	5.91156207680965	0.461501304217041	0.801928980764402	7:107201554-107564514:-	COG5	14;GO:0000139,cellular_component Golgi membrane;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032588,cellular_component trans-Golgi network membrane	NA	component of oligomeric golgi complex 5 [Source:HGNC Symbol%3BAcc:HGNC:14857]
ENSG00000105393	44.99	50.22	43.19	46.98	50.54	47.28	-0.0574994286719218	5.77436495677811	0.461587099645442	0.801928980764402	19:17267349-17281249:+	BABAM1	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0010212,biological_process response to ionizing radiation;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0045739,biological_process positive regulation of DNA repair;GO:0051301,biological_process cell division;GO:0070531,cellular_component BRCA1-A complex;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070552,cellular_component BRISC complex;GO:0071425,biological_process hematopoietic stem cell proliferation	NA	BRISC and BRCA1 A complex member 1 [Source:HGNC Symbol%3BAcc:HGNC:25008]
ENSG00000163156	36.64	31.44	30.72	36.57	31.55	36.89	-0.0733419047989029	4.56397952595713	0.461652913504024	0.801928980764402	1:151156663-151170297:+	SCNM1	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0019899,molecular_function enzyme binding;GO:0046872,molecular_function metal ion binding	NA	sodium channel modifier 1 [Source:HGNC Symbol%3BAcc:HGNC:23136]
ENSG00000165732	35.51	34.17	34.43	37.29	34.06	37.24	-0.0486375030820726	6.38388403885122	0.461659912715896	0.801928980764402	10:68956127-68985073:+	DDX21	25;GO:0000166,molecular_function nucleotide binding;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0009615,biological_process response to virus;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019843,molecular_function rRNA binding;GO:0030515,molecular_function snoRNA binding;GO:0043330,biological_process response to exogenous dsRNA;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0097322,molecular_function 7SK snRNA binding	NA	DExD-box helicase 21 [Source:HGNC Symbol%3BAcc:HGNC:2744]
ENSG00000064933	12.72	14.28	12.87	12.33	12.26	13.92	0.0565702350939672	5.30897130106819	0.461942721254072	0.802307961232236	2:189784084-189877629:+	PMS1	11;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016887,molecular_function ATPase activity;GO:0030983,molecular_function mismatched DNA binding;GO:0032389,cellular_component MutLalpha complex;GO:0042493,biological_process response to drug	NA	PMS1 homolog 1%2C mismatch repair system component [Source:HGNC Symbol%3BAcc:HGNC:9121]
ENSG00000185728	42.32	42.96	42.95	38.98	43.80	42.18	0.0488090812248051	6.28538910913967	0.462071973464602	0.802420174400686	8:63168552-63212786:+	YTHDF3	9;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0043022,molecular_function ribosome binding;GO:0045727,biological_process positive regulation of translation;GO:0045948,biological_process positive regulation of translational initiation;GO:0061157,biological_process mRNA destabilization;GO:1990247,molecular_function N6-methyladenosine-containing RNA binding	NA	YTH N6-methyladenosine RNA binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:26465]
ENSG00000074696	53.20	56.14	52.13	49.04	56.00	51.86	0.0515922089451205	5.9959044539884	0.46219162377197	0.802497868700229	15:65530417-65578352:+	HACD3	32;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0007257,biological_process activation of JUN kinase activity;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016601,biological_process Rac protein signal transduction;GO:0016829,molecular_function lyase activity;GO:0018812,molecular_function 3-hydroxyacyl-CoA dehydratase activity;GO:0019899,molecular_function enzyme binding;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030497,biological_process fatty acid elongation;GO:0031965,cellular_component nuclear membrane;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045070,biological_process positive regulation of viral genome replication;GO:0046726,biological_process positive regulation by virus of viral protein levels in host cell;GO:0102343,molecular_function 3-hydroxy-arachidoyl-CoA dehydratase activity;GO:0102344,molecular_function 3-hydroxy-behenoyl-CoA dehydratase activity;GO:0102345,molecular_function 3-hydroxy-lignoceroyl-CoA dehydratase activity	NA	3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbol%3BAcc:HGNC:24175]
ENSG00000075624	2661.47	3436.44	2577.00	2444.18	3308.54	2462.55	0.0904009611163612	11.6569299978363	0.462246013148041	0.802497868700229	7:5527150-5563784:-	ACTB	44;GO:0000166,molecular_function nucleotide binding;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001895,biological_process retina homeostasis;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0019894,molecular_function kinesin binding;GO:0021762,biological_process substantia nigra development;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030863,cellular_component cortical cytoskeleton;GO:0030957,molecular_function Tat protein binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031982,cellular_component vesicle;GO:0034329,biological_process cell junction assembly;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042802,molecular_function identical protein binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0072562,cellular_component blood microparticle;GO:0097433,cellular_component dense body;GO:0098973,molecular_function structural constituent of postsynaptic actin cytoskeleton;GO:0098974,biological_process postsynaptic actin cytoskeleton organization	NA	actin beta [Source:HGNC Symbol%3BAcc:HGNC:132]
ENSG00000131095	1.77	1.80	2.09	2.51	1.32	2.62	-0.18036151715221	2.15528434279182	0.462514022590324	0.802839740412191	17:44903160-44916937:-	GFAP	37;GO:0005178,molecular_function integrin binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0005883,cellular_component neurofilament;GO:0007010,biological_process cytoskeleton organization;GO:0009611,biological_process response to wounding;GO:0010625,biological_process positive regulation of Schwann cell proliferation;GO:0010977,biological_process negative regulation of neuron projection development;GO:0014002,biological_process astrocyte development;GO:0016020,cellular_component membrane;GO:0019900,molecular_function kinase binding;GO:0030198,biological_process extracellular matrix organization;GO:0031102,biological_process neuron projection regeneration;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0043254,biological_process regulation of protein complex assembly;GO:0044297,cellular_component cell body;GO:0045103,biological_process intermediate filament-based process;GO:0045109,biological_process intermediate filament organization;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051580,biological_process regulation of neurotransmitter uptake;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0060291,biological_process long-term synaptic potentiation;GO:0061564,biological_process axon development;GO:0097386,cellular_component glial cell projection;GO:0097449,cellular_component astrocyte projection;GO:0097450,cellular_component astrocyte end-foot;GO:0098574,cellular_component cytoplasmic side of lysosomal membrane;GO:1904714,biological_process regulation of chaperone-mediated autophagy	GFAP; glial fibrillary acidic protein; K05640	glial fibrillary acidic protein [Source:HGNC Symbol%3BAcc:HGNC:4235]
ENSG00000100100	1.67	0.79	1.44	0.69	1.40	1.16	0.308204158338665	0.410554287214833	0.462591735214021	0.802839740412191	22:31281592-31292534:-	PIK3IP1	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036313,molecular_function phosphatidylinositol 3-kinase catalytic subunit binding;GO:0043553,biological_process negative regulation of phosphatidylinositol 3-kinase activity;GO:0070062,cellular_component extracellular exosome	NA	phosphoinositide-3-kinase interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24942]
ENSG00000154589	31.19	35.24	31.74	29.01	32.39	32.23	0.0724100019569237	3.95084965909575	0.462636966339193	0.802839740412191	8:73991351-74029087:+	LY96	29;GO:0001875,molecular_function lipopolysaccharide receptor activity;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006968,biological_process cellular defense response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0010008,cellular_component endosome membrane;GO:0015026,molecular_function coreceptor activity;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0031666,biological_process positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032496,biological_process response to lipopolysaccharide;GO:0032497,biological_process detection of lipopolysaccharide;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0034128,biological_process negative regulation of MyD88-independent toll-like receptor signaling pathway;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0045087,biological_process innate immune response;GO:0046696,cellular_component lipopolysaccharide receptor complex;GO:0070266,biological_process necroptotic process;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0097190,biological_process apoptotic signaling pathway	LY96, MD-2; lymphocyte antigen 96; K05400	lymphocyte antigen 96 [Source:HGNC Symbol%3BAcc:HGNC:17156]
ENSG00000226174	2.60	2.74	1.96	2.91	3.10	2.73	-0.25838870076633	0.542848378995177	0.462714638034305	0.802862287100898	14:105398578-105450106:+	TEX22	3;GO:0001669,cellular_component acrosomal vesicle;GO:0005737,cellular_component cytoplasm;GO:0031410,cellular_component cytoplasmic vesicle	NA	testis expressed 22 [Source:HGNC Symbol%3BAcc:HGNC:40026]
ENSG00000198728	35.97	37.44	39.93	34.67	38.20	37.18	0.0542341680563404	5.5260881845371	0.462831766686444	0.802953280206685	10:102107559-102120453:-	LDB1	45;GO:0000790,cellular_component nuclear chromatin;GO:0000972,biological_process transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001942,biological_process hair follicle development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009948,biological_process anterior/posterior axis specification;GO:0010669,biological_process epithelial structure maintenance;GO:0016055,biological_process Wnt signaling pathway;GO:0019899,molecular_function enzyme binding;GO:0021549,biological_process cerebellum development;GO:0021702,biological_process cerebellar Purkinje cell differentiation;GO:0022607,biological_process cellular component assembly;GO:0030182,biological_process neuron differentiation;GO:0030274,molecular_function LIM domain binding;GO:0030334,biological_process regulation of cell migration;GO:0031252,cellular_component cell leading edge;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043549,biological_process regulation of kinase activity;GO:0043621,molecular_function protein self-association;GO:0043973,biological_process histone H3-K4 acetylation;GO:0045647,biological_process negative regulation of erythrocyte differentiation;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046985,biological_process positive regulation of hemoglobin biosynthetic process;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0060322,biological_process head development;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	LDB1; LIM domain-binding protein 1; K15617	LIM domain binding 1 [Source:HGNC Symbol%3BAcc:HGNC:6532]
ENSG00000198833	48.86	49.69	51.15	54.55	47.14	55.21	-0.0567445320753587	5.61328394436346	0.4630314277743	0.803187410978534	6:89326624-89352848:-	UBE2J1	17;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007286,biological_process spermatid development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042534,biological_process regulation of tumor necrosis factor biosynthetic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:1904153,biological_process negative regulation of retrograde protein transport, ER to cytosol	UBE2J1, NCUBE1, UBC6; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]; K10578	ubiquitin conjugating enzyme E2 J1 [Source:HGNC Symbol%3BAcc:HGNC:17598]
ENSG00000185324	35.77	33.93	35.31	38.08	35.97	35.62	-0.0486521556490382	5.71197264226258	0.463124813526188	0.803216827178385	16:89680736-89696364:+	CDK10	15;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0007089,biological_process traversing start control point of mitotic cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016592,cellular_component mediator complex;GO:0016740,molecular_function transferase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0097472,molecular_function cyclin-dependent protein kinase activity	NA	cyclin dependent kinase 10 [Source:HGNC Symbol%3BAcc:HGNC:1770]
ENSG00000124209	37.50	33.33	33.01	30.23	34.14	35.28	0.0736234215452777	4.3162918127292	0.463177801413267	0.803216827178385	20:58309695-58367507:+	RAB22A	23;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0007032,biological_process endosome organization;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042995,cellular_component cell projection;GO:0045335,cellular_component phagocytic vesicle;GO:0070062,cellular_component extracellular exosome;GO:0097494,biological_process regulation of vesicle size	RAB22; Ras-related protein Rab-22; K07891	RAB22A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9764]
ENSG00000100033	3.81	3.24	4.58	3.58	3.46	6.13	-0.163861481947597	2.93853868957994	0.463355549491537	0.803412828026044	22:18912776-18936553:-	PRODH	13;GO:0004657,molecular_function proline dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006560,biological_process proline metabolic process;GO:0006562,biological_process proline catabolic process;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010133,biological_process proline catabolic process to glutamate;GO:0010942,biological_process positive regulation of cell death;GO:0016491,molecular_function oxidoreductase activity;GO:0019470,biological_process 4-hydroxyproline catabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	PRODH, fadM, putB; proline dehydrogenase [EC:1.5.5.2]; K00318	proline dehydrogenase 1 [Source:HGNC Symbol%3BAcc:HGNC:9453]
ENSG00000166106	4.11	4.46	3.72	3.78	4.44	3.31	0.100245062815649	3.51395819813096	0.463606316911537	0.803735364779736	11:130448973-130476641:+	ADAMTS15	14;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009986,cellular_component cell surface;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0050840,molecular_function extracellular matrix binding	NA	ADAM metallopeptidase with thrombospondin type 1 motif 15 [Source:HGNC Symbol%3BAcc:HGNC:16305]
ENSG00000213889	4.80	4.11	5.39	4.35	4.32	4.78	0.11009665175938	3.02653041162322	0.463923444382831	0.804117137832339	19:45488776-45502510:+	PPM1N	8;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0006470,biological_process protein dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0046872,molecular_function metal ion binding	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1N (putative) [Source:HGNC Symbol%3BAcc:HGNC:26845]
ENSG00000105254	72.90	77.83	67.96	71.54	76.35	80.79	-0.0556936851232369	6.07172664256447	0.463956089676566	0.804117137832339	19:36114288-36125947:+	TBCB	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030154,biological_process cell differentiation	NA	tubulin folding cofactor B [Source:HGNC Symbol%3BAcc:HGNC:1989]
ENSG00000181016	6.06	7.12	10.13	7.94	5.65	7.14	0.182399493500495	1.76873630889572	0.464106650784124	0.80424580390321	7:112480852-112491062:+	LSMEM1	4;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	leucine rich single-pass membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:22036]
ENSG00000132361	22.65	22.14	22.26	20.87	23.03	21.49	0.0485648593174557	6.48333397541559	0.464159908093337	0.80424580390321	17:2689385-2712663:-	CLUH	5;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005737,cellular_component cytoplasm;GO:0007005,biological_process mitochondrion organization;GO:0048312,biological_process intracellular distribution of mitochondria	NA	clustered mitochondria homolog [Source:HGNC Symbol%3BAcc:HGNC:29094]
ENSG00000114270	78.93	57.32	79.67	84.90	62.36	84.93	-0.0928860263804646	9.37719938018495	0.464726641707585	0.80507018937842	3:48564072-48595267:-	COL7A1	24;GO:0000139,cellular_component Golgi membrane;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005590,cellular_component collagen type VII trimer;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007155,biological_process cell adhesion;GO:0008544,biological_process epidermis development;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030198,biological_process extracellular matrix organization;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035987,biological_process endodermal cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0048208,biological_process COPII vesicle coating	COL7A; collagen, type VII, alpha; K16628	collagen type VII alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2214]
ENSG00000086712	11.28	10.74	12.03	11.91	11.54	12.65	-0.0693220912674139	4.22663640244585	0.464825580088619	0.80507018937842	X:16786426-16844519:+	TXLNG	13;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0010564,biological_process regulation of cell cycle process;GO:0016020,cellular_component membrane;GO:0019905,molecular_function syntaxin binding;GO:0030500,biological_process regulation of bone mineralization;GO:0031965,cellular_component nuclear membrane;GO:0046982,molecular_function protein heterodimerization activity;GO:0051726,biological_process regulation of cell cycle	NA	taxilin gamma [Source:HGNC Symbol%3BAcc:HGNC:18578]
ENSG00000237651	49.14	47.78	45.17	48.73	51.36	48.65	-0.0540665693707179	5.20245781594772	0.464830262408373	0.80507018937842	2:61145067-61164829:+	C2orf74	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 2 open reading frame 74 [Source:HGNC Symbol%3BAcc:HGNC:34439]
ENSG00000108671	42.79	45.21	44.59	45.47	40.83	42.76	0.0492335668533294	5.92859394360059	0.464936171378625	0.805127361401098	17:32444260-32483318:+	PSMD11	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043248,biological_process proteasome assembly;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0048863,biological_process stem cell differentiation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD11, RPN6; 26S proteasome regulatory subunit N6; K03036	proteasome 26S subunit%2C non-ATPase 11 [Source:HGNC Symbol%3BAcc:HGNC:9556]
ENSG00000126457	133.71	132.79	124.50	133.03	137.06	136.63	-0.0454678488634782	7.37306826288844	0.46512665716926	0.805127361401098	19:49675785-49689029:+	PRMT1	37;GO:0001701,biological_process in utero embryonic development;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006479,biological_process protein methylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008168,molecular_function methyltransferase activity;GO:0008170,molecular_function N-methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008327,molecular_function methyl-CpG binding;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018216,biological_process peptidyl-arginine methylation;GO:0019899,molecular_function enzyme binding;GO:0019919,biological_process peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0031175,biological_process neuron projection development;GO:0032259,biological_process methylation;GO:0034709,cellular_component methylosome;GO:0035242,molecular_function protein-arginine omega-N asymmetric methyltransferase activity;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0042054,molecular_function histone methyltransferase activity;GO:0042802,molecular_function identical protein binding;GO:0043985,biological_process histone H4-R3 methylation;GO:0044020,molecular_function histone methyltransferase activity (H4-R3 specific);GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045653,biological_process negative regulation of megakaryocyte differentiation;GO:0046985,biological_process positive regulation of hemoglobin biosynthetic process;GO:0048273,molecular_function mitogen-activated protein kinase p38 binding;GO:1900745,biological_process positive regulation of p38MAPK cascade	NA	protein arginine methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:5187]
ENSG00000234616	6.31	6.40	5.92	6.10	6.35	5.18	0.0907407424791399	3.45378185910202	0.465129614516148	0.805127361401098	8:142657459-142681968:-	JRK	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	Jrk helix-turn-helix protein [Source:HGNC Symbol%3BAcc:HGNC:6199]
ENSG00000138246	23.57	24.31	24.08	22.22	24.71	23.30	0.0468730068873556	7.34094996525585	0.465162600398094	0.805127361401098	3:132417525-132539032:+	DNAJC13	23;GO:0001649,biological_process osteoblast differentiation;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007032,biological_process endosome organization;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031901,cellular_component early endosome membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0071203,cellular_component WASH complex;GO:1902954,biological_process regulation of early endosome to recycling endosome transport;GO:2000641,biological_process regulation of early endosome to late endosome transport	NA	DnaJ heat shock protein family (Hsp40) member C13 [Source:HGNC Symbol%3BAcc:HGNC:30343]
ENSG00000178338	9.04	11.35	10.14	9.26	9.83	10.00	0.0719417300843813	4.19665963471801	0.465187580437338	0.805127361401098	5:178859952-178888122:+	ZNF354B	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 354B [Source:HGNC Symbol%3BAcc:HGNC:17197]
ENSG00000138101	7.10	5.54	7.12	5.73	5.69	7.21	0.104115537169751	3.6156068507439	0.465432181238415	0.805436417390307	2:25377197-25673647:-	DTNB	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding	NA	dystrobrevin beta [Source:HGNC Symbol%3BAcc:HGNC:3058]
ENSG00000168002	116.11	129.92	117.86	125.25	125.59	128.42	-0.0513598874036439	6.18686995062346	0.46549592027375	0.805436417390307	11:62761543-62766710:+	POLR2G	27;GO:0000291,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006915,biological_process apoptotic process;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0031369,molecular_function translation initiation factor binding;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045948,biological_process positive regulation of translational initiation;GO:0050434,biological_process positive regulation of viral transcription;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB7, POLR2G; DNA-directed RNA polymerase II subunit RPB7; K03015	RNA polymerase II subunit G [Source:HGNC Symbol%3BAcc:HGNC:9194]
ENSG00000153233	0.90	0.94	1.24	1.30	0.50	0.83	0.245786468850976	1.12357739085282	0.465667435752004	0.805546870732834	12:70638072-70920843:-	PTPRR	22;GO:0001701,biological_process in utero embryonic development;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0038128,biological_process ERBB2 signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	PTPRR; receptor-type tyrosine-protein phosphatase R [EC:3.1.3.48]; K04458	protein tyrosine phosphatase%2C receptor type R [Source:HGNC Symbol%3BAcc:HGNC:9680]
ENSG00000056487	1.23	0.95	1.37	1.53	1.69	0.96	-0.201826556881537	1.16444318316964	0.465689546796006	0.805546870732834	22:44881161-45009999:-	PHF21B	7;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding	NA	PHD finger protein 21B [Source:HGNC Symbol%3BAcc:HGNC:25161]
ENSG00000164253	17.04	15.54	18.15	19.02	16.67	17.96	-0.0636582466181038	4.70644540404876	0.465802899335611	0.805625157086688	5:77425969-77620611:-	WDR41	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0006914,biological_process autophagy;GO:0010506,biological_process regulation of autophagy;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0032045,cellular_component guanyl-nucleotide exchange factor complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:1990316,cellular_component ATG1/ULK1 kinase complex	NA	WD repeat domain 41 [Source:HGNC Symbol%3BAcc:HGNC:25601]
ENSG00000116685	21.55	23.37	24.68	20.50	23.81	23.02	0.0584831752314958	5.52878576917047	0.465868841805022	0.805625157086688	1:11919590-11926428:-	KIAA2013	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	KIAA2013 [Source:HGNC Symbol%3BAcc:HGNC:28513]
ENSG00000125827	22.44	23.20	21.39	23.18	25.19	22.21	-0.0644703002748202	4.67573017160611	0.465929509604877	0.805625157086688	20:7977347-8019829:-	TMX4	9;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process	NA	thioredoxin related transmembrane protein 4 [Source:HGNC Symbol%3BAcc:HGNC:25237]
ENSG00000123728	24.70	26.63	29.76	27.55	28.04	30.74	-0.0797820235116423	3.95380681487512	0.466092574949302	0.805794865298842	X:132203023-132219480:-	RAP2C	24;GO:0000166,molecular_function nucleotide binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030336,biological_process negative regulation of cell migration;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032486,biological_process Rap protein signal transduction;GO:0043312,biological_process neutrophil degranulation;GO:0044291,cellular_component cell-cell contact zone;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061097,biological_process regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:1903506,biological_process regulation of nucleic acid-templated transcription	RAP2C; Ras-related protein Rap-2C; K07839	RAP2C%2C member of RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:21165]
ENSG00000134899	0.33	0.24	0.34	0.20	0.27	0.29	0.27763696942887	0.235956986857001	0.466287662759094	0.80594739680501	13:102844843-102876001:+	ERCC5	32;GO:0000405,molecular_function bubble DNA binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0005675,cellular_component holo TFIIH complex;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0009650,biological_process UV protection;GO:0010225,biological_process response to UV-C;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding	ERCC5, XPG, RAD2; DNA excision repair protein ERCC-5; K10846	ERCC excision repair 5%2C endonuclease [Source:HGNC Symbol%3BAcc:HGNC:3437]
ENSG00000084092	17.77	16.93	15.89	16.77	17.46	18.84	-0.0577585821395192	5.18467434291882	0.466380405221798	0.80594739680501	4:56963369-56978823:-	NOA1	14;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006915,biological_process apoptotic process;GO:0010941,biological_process regulation of cell death;GO:0016020,cellular_component membrane;GO:0031314,cellular_component extrinsic component of mitochondrial inner membrane;GO:0032543,biological_process mitochondrial translation;GO:0042254,biological_process ribosome biogenesis;GO:0043457,biological_process regulation of cellular respiration	NA	nitric oxide associated 1 [Source:HGNC Symbol%3BAcc:HGNC:28473]
ENSG00000143815	39.35	38.80	40.25	39.73	44.11	39.75	-0.0491183043199859	6.22155593533304	0.466401071029308	0.80594739680501	1:225401501-225428925:-	LBR	18;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0006695,biological_process cholesterol biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0016628,molecular_function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0031965,cellular_component nuclear membrane;GO:0050613,molecular_function delta14-sterol reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070087,molecular_function chromo shadow domain binding	NA	lamin B receptor [Source:HGNC Symbol%3BAcc:HGNC:6518]
ENSG00000148655	12.19	14.28	14.10	14.34	11.75	12.04	0.0959897688675906	3.28969443937224	0.466440513868299	0.80594739680501	10:75431452-76560167:+	LRMDA	2;GO:0030154,biological_process cell differentiation;GO:0030318,biological_process melanocyte differentiation	NA	leucine rich melanocyte differentiation associated [Source:HGNC Symbol%3BAcc:HGNC:23405]
ENSG00000105327	10.55	11.84	12.41	11.09	11.33	10.42	0.0929817709928029	3.16407724615892	0.466551496939094	0.805987776927281	19:47220821-47232766:-	BBC3	32;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001844,biological_process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008340,biological_process determination of adult lifespan;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045926,biological_process negative regulation of growth;GO:0051117,molecular_function ATPase binding;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070245,biological_process positive regulation of thymocyte apoptotic process;GO:0071456,biological_process cellular response to hypoxia;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:0097194,biological_process execution phase of apoptosis;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response;GO:2001056,biological_process positive regulation of cysteine-type endopeptidase activity;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BBC3, PUMA; Bcl-2-binding component 3; K10132	BCL2 binding component 3 [Source:HGNC Symbol%3BAcc:HGNC:17868]
ENSG00000122507	13.33	14.11	11.24	13.08	12.58	11.51	0.0658523746826264	5.20648928087228	0.466606682738975	0.805987776927281	7:33129243-33606068:+	BBS9	23;GO:0000242,cellular_component pericentriolar material;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007601,biological_process visual perception;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0034451,cellular_component centriolar satellite;GO:0034464,cellular_component BBSome;GO:0035869,cellular_component ciliary transition zone;GO:0042995,cellular_component cell projection;GO:0045444,biological_process fat cell differentiation;GO:0050896,biological_process response to stimulus;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0061512,biological_process protein localization to cilium	NA	Bardet-Biedl syndrome 9 [Source:HGNC Symbol%3BAcc:HGNC:30000]
ENSG00000146648	54.55	46.62	53.66	55.13	51.15	55.67	-0.05197811989798	7.73369206776664	0.466814968811512	0.805987776927281	7:55019020-55211628:+	EGFR	176;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000902,biological_process cell morphogenesis;GO:0001503,biological_process ossification;GO:0001618,molecular_function virus receptor activity;GO:0001889,biological_process liver development;GO:0001892,biological_process embryonic placenta development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001942,biological_process hair follicle development;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0004716,molecular_function receptor signaling protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005006,molecular_function epidermal growth factor-activated receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006412,biological_process translation;GO:0006468,biological_process protein phosphorylation;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006950,biological_process response to stress;GO:0006970,biological_process response to osmotic stress;GO:0006979,biological_process response to oxidative stress;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007202,biological_process activation of phospholipase C activity;GO:0007275,biological_process multicellular organism development;GO:0007435,biological_process salivary gland morphogenesis;GO:0007494,biological_process midgut development;GO:0007611,biological_process learning or memory;GO:0007623,biological_process circadian rhythm;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008544,biological_process epidermis development;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0010960,biological_process magnesium ion homeostasis;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016101,biological_process diterpenoid metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0021795,biological_process cerebral cortex cell migration;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030139,cellular_component endocytic vesicle;GO:0030235,molecular_function nitric-oxide synthase regulator activity;GO:0030307,biological_process positive regulation of cell growth;GO:0030324,biological_process lung development;GO:0030335,biological_process positive regulation of cell migration;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031659,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0031901,cellular_component early endosome membrane;GO:0031965,cellular_component nuclear membrane;GO:0032355,biological_process response to estradiol;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033590,biological_process response to cobalamin;GO:0033594,biological_process response to hydroxyisoflavone;GO:0033993,biological_process response to lipid;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0035556,biological_process intracellular signal transduction;GO:0035690,biological_process cellular response to drug;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042698,biological_process ovulation cycle;GO:0042743,biological_process hydrogen peroxide metabolic process;GO:0042802,molecular_function identical protein binding;GO:0043006,biological_process activation of phospholipase A2 activity by calcium-mediated signaling;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043235,cellular_component receptor complex;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043586,biological_process tongue development;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045739,biological_process positive regulation of DNA repair;GO:0045740,biological_process positive regulation of DNA replication;GO:0045780,biological_process positive regulation of bone resorption;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046328,biological_process regulation of JNK cascade;GO:0046718,biological_process viral entry into host cell;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048143,biological_process astrocyte activation;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048408,molecular_function epidermal growth factor binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048546,biological_process digestive tract morphogenesis;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048812,biological_process neuron projection morphogenesis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051015,molecular_function actin filament binding;GO:0051205,biological_process protein insertion into membrane;GO:0051592,biological_process response to calcium ion;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060571,biological_process morphogenesis of an epithelial fold;GO:0061024,biological_process membrane organization;GO:0061029,biological_process eyelid development in camera-type eye;GO:0070141,biological_process response to UV-A;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070435,cellular_component Shc-EGFR complex;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071276,biological_process cellular response to cadmium ion;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0097421,biological_process liver regeneration;GO:0097489,cellular_component multivesicular body, internal vesicle lumen;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1900020,biological_process positive regulation of protein kinase C activity;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1902722,biological_process positive regulation of prolactin secretion;GO:1903078,biological_process positive regulation of protein localization to plasma membrane;GO:1903800,biological_process positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1905208,biological_process negative regulation of cardiocyte differentiation;GO:2000145,biological_process regulation of cell motility	EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]; K04361	epidermal growth factor receptor [Source:HGNC Symbol%3BAcc:HGNC:3236]
ENSG00000068878	11.75	13.07	11.49	12.84	13.15	11.95	-0.0548561592817953	6.0991832357224	0.466876106087473	0.805987776927281	2:53864066-53970840:-	PSME4	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006281,biological_process DNA repair;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0010499,biological_process proteasomal ubiquitin-independent protein catabolic process;GO:0010952,biological_process positive regulation of peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016504,molecular_function peptidase activator activity;GO:0016579,biological_process protein deubiquitination;GO:0016607,cellular_component nuclear speck;GO:0030154,biological_process cell differentiation;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0035093,biological_process spermatogenesis, exchange of chromosomal proteins;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0070628,molecular_function proteasome binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1990111,cellular_component spermatoproteasome complex	PSME4; proteasome activator subunit 4; K06699	proteasome activator subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:20635]
ENSG00000250317	35.87	34.70	38.70	42.04	36.72	37.11	-0.0690645010716582	4.25553702044493	0.467287009474984	0.805987776927281	4:25861829-25929874:+	SMIM20	6;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	small integral membrane protein 20 [Source:HGNC Symbol%3BAcc:HGNC:37260]
ENSG00000196476	12.17	14.68	14.58	13.96	14.68	15.30	-0.0805493949139257	4.01458080858496	0.467289737207683	0.805987776927281	20:270862-290778:-	C20orf96	3;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	chromosome 20 open reading frame 96 [Source:HGNC Symbol%3BAcc:HGNC:16227]
ENSG00000186187	11.01	10.33	9.56	12.22	8.91	12.43	-0.108425005869624	3.39450241746386	0.467327917117652	0.805987776927281	16:74999029-75110994:+	ZNRF1	17;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination	NA	zinc and ring finger 1 [Source:HGNC Symbol%3BAcc:HGNC:18452]
ENSG00000004864	32.35	36.80	31.03	28.83	36.50	31.03	0.0655452947817635	6.05571126858953	0.467342418299379	0.805987776927281	7:96120219-96322147:-	SLC25A13	22;GO:0005215,molecular_function transporter activity;GO:0005313,molecular_function L-glutamate transmembrane transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006094,biological_process gluconeogenesis;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0015172,molecular_function acidic amino acid transmembrane transporter activity;GO:0015183,molecular_function L-aspartate transmembrane transporter activity;GO:0015810,biological_process aspartate transport;GO:0015813,biological_process L-glutamate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043490,biological_process malate-aspartate shuttle;GO:0045333,biological_process cellular respiration;GO:0046872,molecular_function metal ion binding;GO:0051592,biological_process response to calcium ion;GO:0055085,biological_process transmembrane transport;GO:0089711,biological_process L-glutamate transmembrane transport;GO:0089712,biological_process L-aspartate transmembrane transport	NA	solute carrier family 25 member 13 [Source:HGNC Symbol%3BAcc:HGNC:10983]
ENSG00000130349	22.48	21.97	21.23	20.17	23.32	19.42	0.0757271548883479	3.99070052414035	0.467352338232713	0.805987776927281	6:107028212-107051342:+	C6orf203	1;GO:0005739,cellular_component mitochondrion	NA	chromosome 6 open reading frame 203 [Source:HGNC Symbol%3BAcc:HGNC:17971]
ENSG00000198556	7.18	8.47	7.96	7.76	8.36	9.08	-0.0902631792602237	3.65793231323322	0.467462782465605	0.805987776927281	7:99472840-99503650:+	ZNF789	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 789 [Source:HGNC Symbol%3BAcc:HGNC:27801]
ENSG00000070495	20.43	18.30	20.78	20.73	18.96	17.77	0.067973674502438	4.83320229505115	0.467474323242822	0.805987776927281	17:76712831-76726799:-	JMJD6	44;GO:0001568,biological_process blood vessel development;GO:0001822,biological_process kidney development;GO:0002040,biological_process sprouting angiogenesis;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004872,molecular_function receptor activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0008380,biological_process RNA splicing;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0018395,biological_process peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032452,molecular_function histone demethylase activity;GO:0033077,biological_process T cell differentiation in thymus;GO:0033746,molecular_function histone demethylase activity (H3-R2 specific);GO:0033749,molecular_function histone demethylase activity (H4-R3 specific);GO:0042116,biological_process macrophage activation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043277,biological_process apoptotic cell clearance;GO:0043654,biological_process recognition of apoptotic cell;GO:0046872,molecular_function metal ion binding;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0048821,biological_process erythrocyte development;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060041,biological_process retina development in camera-type eye;GO:0070078,biological_process histone H3-R2 demethylation;GO:0070079,biological_process histone H4-R3 demethylation;GO:0070815,molecular_function peptidyl-lysine 5-dioxygenase activity	NA	arginine demethylase and lysine hydroxylase [Source:HGNC Symbol%3BAcc:HGNC:19355]
ENSG00000130748	14.15	15.08	11.61	12.48	15.06	16.83	-0.117179115759604	3.02827159065574	0.467516566610111	0.805987776927281	19:47045906-47048630:-	TMEM160	3;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 160 [Source:HGNC Symbol%3BAcc:HGNC:26042]
ENSG00000104825	11.99	12.88	14.42	14.66	14.99	12.38	-0.0838036100470195	3.93022919947302	0.467567657947918	0.805987776927281	19:38899699-38908893:+	NFKBIB	10;GO:0003713,molecular_function transcription coactivator activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0071222,biological_process cellular response to lipopolysaccharide	NFKBIB; NF-kappa-B inhibitor beta; K02581	NFKB inhibitor beta [Source:HGNC Symbol%3BAcc:HGNC:7798]
ENSG00000092470	12.22	11.55	11.80	14.39	10.42	13.14	-0.0812012171070207	4.53688882117057	0.467598362319159	0.805987776927281	15:43826962-43868419:+	WDR76	4;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:2000001,biological_process regulation of DNA damage checkpoint	NA	WD repeat domain 76 [Source:HGNC Symbol%3BAcc:HGNC:25773]
ENSG00000087502	42.75	47.90	41.73	45.57	48.69	44.24	-0.0572219042933268	5.73004199793036	0.467728233005835	0.805987776927281	12:29337351-29381189:-	ERGIC2	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	ERGIC and golgi 2 [Source:HGNC Symbol%3BAcc:HGNC:30208]
ENSG00000109920	25.63	22.68	25.64	23.95	23.84	24.32	0.0513325231306716	6.21973987304103	0.467779924052834	0.805987776927281	11:47716516-47767443:-	FNBP4	2;GO:0005515,molecular_function protein binding;GO:0016607,cellular_component nuclear speck	NA	formin binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:19752]
ENSG00000175470	17.44	18.57	16.29	18.83	18.62	17.50	-0.0637743540952998	4.77388300152408	0.467837392754042	0.805987776927281	10:131900643-131959834:+	PPP2R2D	13;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000278,biological_process mitotic cell cycle;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0010458,biological_process exit from mitosis;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0032502,biological_process developmental process;GO:0050790,biological_process regulation of catalytic activity;GO:0051301,biological_process cell division;GO:0070262,biological_process peptidyl-serine dephosphorylation	PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B; K04354	protein phosphatase 2 regulatory subunit Bdelta [Source:HGNC Symbol%3BAcc:HGNC:23732]
ENSG00000160679	64.62	68.30	66.47	74.28	68.70	65.44	-0.0533594193108734	5.70294876425627	0.467918449847876	0.805987776927281	1:153633981-153646306:+	CHTOP	21;GO:0000346,cellular_component transcription export complex;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008327,molecular_function methyl-CpG binding;GO:0016607,cellular_component nuclear speck;GO:0031062,biological_process positive regulation of histone methylation;GO:0031124,biological_process mRNA 3'-end processing;GO:0032781,biological_process positive regulation of ATPase activity;GO:0051028,biological_process mRNA transport;GO:0051096,biological_process positive regulation of helicase activity	NA	chromatin target of PRMT1 [Source:HGNC Symbol%3BAcc:HGNC:24511]
ENSG00000125877	53.76	49.75	54.51	51.84	57.60	56.67	-0.0565400310116382	4.98436343069644	0.467931354267077	0.805987776927281	20:3208867-3223870:+	ITPA	17;GO:0000166,molecular_function nucleotide binding;GO:0004551,molecular_function nucleotide diphosphatase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006193,biological_process ITP catabolic process;GO:0006195,biological_process purine nucleotide catabolic process;GO:0009117,biological_process nucleotide metabolic process;GO:0009143,biological_process nucleoside triphosphate catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0035529,molecular_function NADH pyrophosphatase activity;GO:0035870,molecular_function dITP diphosphatase activity;GO:0036220,molecular_function ITP diphosphatase activity;GO:0036222,molecular_function XTP diphosphatase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0047429,molecular_function nucleoside-triphosphate diphosphatase activity;GO:0051276,biological_process chromosome organization	ITPA; inosine triphosphate pyrophosphatase [EC:3.6.1.-]; K01519	inosine triphosphatase [Source:HGNC Symbol%3BAcc:HGNC:6176]
ENSG00000139324	8.11	7.75	7.89	7.70	7.91	7.33	0.0643662632321928	4.43650156839172	0.467968053536401	0.805987776927281	12:88142295-88199887:+	TMTC3	6;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process	NA	transmembrane and tetratricopeptide repeat containing 3 [Source:HGNC Symbol%3BAcc:HGNC:26899]
ENSG00000137720	31.24	26.88	31.95	32.87	32.31	30.53	-0.0666755896101195	4.26743682694333	0.467988490466834	0.805987776927281	11:111878934-111885975:+	C11orf1	4;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008150,biological_process biological_process	NA	chromosome 11 open reading frame 1 [Source:HGNC Symbol%3BAcc:HGNC:1163]
ENSG00000164209	23.94	24.46	23.48	23.17	24.74	27.65	-0.0628575722353248	4.95375855015611	0.467998739871853	0.805987776927281	5:110738135-110765161:+	SLC25A46	7;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0090149,biological_process mitochondrial membrane fission	NA	solute carrier family 25 member 46 [Source:HGNC Symbol%3BAcc:HGNC:25198]
ENSG00000165757	28.24	25.27	28.85	27.55	24.54	27.94	0.0547252602349174	6.78964679685152	0.468025668187924	0.805987776927281	10:30012799-30115494:-	JCAD	4;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0007155,biological_process cell adhesion;GO:0030054,cellular_component cell junction	NA	junctional cadherin 5 associated [Source:HGNC Symbol%3BAcc:HGNC:29283]
ENSG00000006747	1.73	2.14	1.30	1.70	2.21	1.84	-0.16000636039814	2.14997179066565	0.468087975959065	0.805987776927281	7:12570576-12660179:+	SCIN	27;GO:0001786,molecular_function phosphatidylserine binding;GO:0002102,cellular_component podosome;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005903,cellular_component brush border;GO:0005938,cellular_component cell cortex;GO:0008285,biological_process negative regulation of cell proliferation;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0030054,cellular_component cell junction;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0042989,biological_process sequestering of actin monomers;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045010,biological_process actin nucleation;GO:0045654,biological_process positive regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0051014,biological_process actin filament severing;GO:0051015,molecular_function actin filament binding;GO:0051047,biological_process positive regulation of secretion;GO:0051127,biological_process positive regulation of actin nucleation;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome	GSN; gelsolin; K05768	scinderin [Source:HGNC Symbol%3BAcc:HGNC:21695]
ENSG00000197694	58.26	57.63	56.53	61.03	59.01	58.88	-0.04164867583982	8.83924060752617	0.468146819586415	0.805987776927281	9:128552557-128633662:+	SPTAN1	28;GO:0000165,biological_process MAPK cascade;GO:0003779,molecular_function actin binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007010,biological_process cytoskeleton organization;GO:0007411,biological_process axon guidance;GO:0008091,cellular_component spectrin;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0035580,cellular_component specific granule lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle;GO:1904724,cellular_component tertiary granule lumen	SPTA; spectrin alpha; K06114	spectrin alpha%2C non-erythrocytic 1 [Source:HGNC Symbol%3BAcc:HGNC:11273]
ENSG00000141699	16.21	17.38	17.20	17.24	16.33	15.42	0.0621750631689808	4.61744917792378	0.468291700587458	0.805987776927281	17:42579512-42610623:-	RETREG3	4;GO:0005515,molecular_function protein binding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	reticulophagy regulator family member 3 [Source:HGNC Symbol%3BAcc:HGNC:27258]
ENSG00000130584	1.84	1.73	1.87	1.86	1.93	2.31	-0.151771023649172	1.83590500475472	0.468341435820258	0.805987776927281	20:63743665-63831244:-	ZBTB46	10;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030853,biological_process negative regulation of granulocyte differentiation;GO:0045650,biological_process negative regulation of macrophage differentiation;GO:0045656,biological_process negative regulation of monocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:2001199,biological_process negative regulation of dendritic cell differentiation;GO:2001200,biological_process positive regulation of dendritic cell differentiation	NA	zinc finger and BTB domain containing 46 [Source:HGNC Symbol%3BAcc:HGNC:16094]
ENSG00000143811	17.29	15.73	17.63	16.61	17.22	14.72	0.0800258026245328	4.0042010375444	0.468344606784524	0.805987776927281	1:225919876-225924340:-	PYCR2	10;GO:0004735,molecular_function pyrroline-5-carboxylate reductase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006561,biological_process proline biosynthetic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0055114,biological_process oxidation-reduction process;GO:0055129,biological_process L-proline biosynthetic process	proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]; K00286	pyrroline-5-carboxylate reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:30262]
ENSG00000136305	38.38	35.64	35.40	40.34	34.63	40.56	-0.0658895046847487	4.63413824517547	0.468390819477126	0.805987776927281	14:24305095-24311430:-	CIDEB	12;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010942,biological_process positive regulation of cell death;GO:0042802,molecular_function identical protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097194,biological_process execution phase of apoptosis;GO:0097202,biological_process activation of cysteine-type endopeptidase activity	NA	cell death-inducing DFFA-like effector b [Source:HGNC Symbol%3BAcc:HGNC:1977]
ENSG00000184363	8.49	7.17	8.32	7.04	7.84	8.19	0.0740913806146953	4.4078914497362	0.468480369073933	0.805987776927281	11:392613-404908:+	PKP3	22;GO:0001533,cellular_component cornified envelope;GO:0002159,biological_process desmosome assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0007155,biological_process cell adhesion;GO:0010628,biological_process positive regulation of gene expression;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019899,molecular_function enzyme binding;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0031424,biological_process keratinization;GO:0045294,molecular_function alpha-catenin binding;GO:0050839,molecular_function cell adhesion molecule binding;GO:0070268,biological_process cornification;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:1902373,biological_process negative regulation of mRNA catabolic process;GO:1990124,cellular_component messenger ribonucleoprotein complex	NA	plakophilin 3 [Source:HGNC Symbol%3BAcc:HGNC:9025]
ENSG00000137414	6.27	7.33	5.05	6.22	5.82	5.16	0.116621411555243	2.90726694280677	0.468547472639714	0.805987776927281	6:17600354-17611719:+	FAM8A1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 8 member A1 [Source:HGNC Symbol%3BAcc:HGNC:16372]
ENSG00000072803	21.44	21.97	20.16	22.07	22.69	21.66	-0.0536033954253783	5.30558396228842	0.468597983760869	0.805987776927281	5:171861548-172006873:-	FBXW11	31;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031648,biological_process protein destabilization;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0042753,biological_process positive regulation of circadian rhythm;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0045862,biological_process positive regulation of proteolysis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051403,biological_process stress-activated MAPK cascade;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	F-box and WD repeat domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:13607]
ENSG00000142798	61.46	58.69	61.75	63.73	61.72	63.29	-0.0413328336048549	9.69150632737607	0.468683993452587	0.805987776927281	1:21822244-21937297:-	HSPG2	26;GO:0001523,biological_process retinoid metabolic process;GO:0001525,biological_process angiogenesis;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008022,molecular_function protein C-terminus binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0031012,cellular_component extracellular matrix;GO:0043202,cellular_component lysosomal lumen;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0070062,cellular_component extracellular exosome;GO:0098797,cellular_component plasma membrane protein complex	HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein; K06255	heparan sulfate proteoglycan 2 [Source:HGNC Symbol%3BAcc:HGNC:5273]
ENSG00000155729	18.07	15.78	15.38	17.99	17.15	16.95	-0.0654266529037302	4.44462071929596	0.468777499587306	0.805987776927281	2:200488951-200519784:-	KCTD18	1;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 18 [Source:HGNC Symbol%3BAcc:HGNC:26446]
ENSG00000109917	35.54	33.22	37.46	40.35	34.10	37.09	-0.0563673320667697	5.67490966517652	0.468798718899949	0.805987776927281	11:116773798-116788050:-	ZPR1	40;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001833,biological_process inner cell mass cell proliferation;GO:0001834,biological_process trophectodermal cell proliferation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008380,biological_process RNA splicing;GO:0010628,biological_process positive regulation of gene expression;GO:0015030,cellular_component Cajal body;GO:0021510,biological_process spinal cord development;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030576,biological_process Cajal body organization;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031369,molecular_function translation initiation factor binding;GO:0031641,biological_process regulation of myelination;GO:0032797,cellular_component SMN complex;GO:0033120,biological_process positive regulation of RNA splicing;GO:0042023,biological_process DNA endoreduplication;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043204,cellular_component perikaryon;GO:0045927,biological_process positive regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061564,biological_process axon development;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071931,biological_process positive regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0097504,cellular_component Gemini of coiled bodies;GO:1902742,biological_process apoptotic process involved in development;GO:1990261,biological_process pre-mRNA catabolic process;GO:2000672,biological_process negative regulation of motor neuron apoptotic process	NA	ZPR1 zinc finger [Source:HGNC Symbol%3BAcc:HGNC:13051]
ENSG00000128607	18.11	16.79	18.71	18.29	16.93	16.55	0.0671462434684255	4.55299507772118	0.468801397681057	0.805987776927281	7:130070509-130135720:+	KLHDC10	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm	NA	kelch domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:22194]
ENSG00000119685	11.95	12.59	9.92	10.09	12.20	10.77	0.0689713394123208	5.51672798447013	0.468905697229206	0.806014576241182	14:75633624-75955078:+	TTLL5	21;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006351,biological_process transcription, DNA-templated;GO:0006464,biological_process cellular protein modification process;GO:0007283,biological_process spermatogenesis;GO:0007288,biological_process sperm axoneme assembly;GO:0009566,biological_process fertilization;GO:0016874,molecular_function ligase activity;GO:0018095,biological_process protein polyglutamylation;GO:0030317,biological_process sperm motility;GO:0042995,cellular_component cell projection;GO:0060041,biological_process retina development in camera-type eye;GO:0070740,molecular_function tubulin-glutamic acid ligase activity	NA	tubulin tyrosine ligase like 5 [Source:HGNC Symbol%3BAcc:HGNC:19963]
ENSG00000124574	5.75	6.06	6.21	6.02	5.83	5.59	0.0587278699251206	4.7935089862486	0.468946851656636	0.806014576241182	6:43427365-43450430:+	ABCC10	13;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043225,molecular_function anion transmembrane-transporting ATPase activity;GO:0055085,biological_process transmembrane transport;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport	ABCC10; ATP-binding cassette, subfamily C (CFTR/MRP), member 10; K05674	ATP binding cassette subfamily C member 10 [Source:HGNC Symbol%3BAcc:HGNC:52]
ENSG00000152382	13.14	12.93	13.33	11.70	12.30	13.64	0.0769789793188692	3.70811341827231	0.469353366226335	0.806290128185973	1:166856509-166876327:-	TADA1	13;GO:0000124,cellular_component SAGA complex;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0030914,cellular_component STAGA complex;GO:0043966,biological_process histone H3 acetylation;GO:0070461,cellular_component SAGA-type complex	NA	transcriptional adaptor 1 [Source:HGNC Symbol%3BAcc:HGNC:30631]
ENSG00000122257	21.08	21.62	21.48	22.57	22.93	21.31	-0.0464016599332336	6.8939547687057	0.46936301129579	0.806290128185973	16:24537692-24572863:+	RBBP6	29;GO:0000209,biological_process protein polyubiquitination;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006260,biological_process DNA replication;GO:0006275,biological_process regulation of DNA replication;GO:0006397,biological_process mRNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0035264,biological_process multicellular organism growth;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0048568,biological_process embryonic organ development;GO:0061053,biological_process somite development;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	RB binding protein 6%2C ubiquitin ligase [Source:HGNC Symbol%3BAcc:HGNC:9889]
ENSG00000189060	43.20	40.23	47.80	51.59	39.88	48.21	-0.0750426217976301	4.72825075771639	0.469386316973421	0.806290128185973	22:37805092-37807436:+	H1F0	17;GO:0000786,cellular_component nucleosome;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0003680,molecular_function AT DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005719,cellular_component nuclear euchromatin;GO:0005794,cellular_component Golgi apparatus;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006334,biological_process nucleosome assembly;GO:0015629,cellular_component actin cytoskeleton;GO:0016604,cellular_component nuclear body;GO:0031490,molecular_function chromatin DNA binding	NA	H1 histone family member 0 [Source:HGNC Symbol%3BAcc:HGNC:4714]
ENSG00000178585	22.67	27.14	28.17	28.35	31.84	25.18	-0.12157787553293	2.75619462662204	0.469413632001098	0.806290128185973	1:9848275-9910336:-	CTNNBIP1	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0002528,biological_process regulation of vascular permeability involved in acute inflammatory response;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008013,molecular_function beta-catenin binding;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016055,biological_process Wnt signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030877,cellular_component beta-catenin destruction complex;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0032091,biological_process negative regulation of protein binding;GO:0043392,biological_process negative regulation of DNA binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045657,biological_process positive regulation of monocyte differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0060633,biological_process negative regulation of transcription initiation from RNA polymerase II promoter;GO:0070016,molecular_function armadillo repeat domain binding;GO:0072201,biological_process negative regulation of mesenchymal cell proliferation	ICAT, CTNNBIP1; beta-catenin-interacting protein 1 (inhibitor of beta-catenin and Tcf-4); K04493	catenin beta interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16913]
ENSG00000147573	3.63	2.76	3.40	4.24	2.58	4.14	-0.14355548233597	2.63113683236929	0.469452394203263	0.806290128185973	8:66126895-66175487:+	TRIM55	10;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005874,cellular_component microtubule;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 55 [Source:HGNC Symbol%3BAcc:HGNC:14215]
ENSG00000118503	6.50	5.08	5.62	5.88	4.99	5.46	0.0955334684114191	3.74900745109911	0.469549064054538	0.806290128185973	6:137867187-137883312:+	TNFAIP3	78;GO:0001922,biological_process B-1 B cell homeostasis;GO:0002020,molecular_function protease binding;GO:0002237,biological_process response to molecule of bacterial origin;GO:0002634,biological_process regulation of germinal center formation;GO:0002677,biological_process negative regulation of chronic inflammatory response;GO:0003677,molecular_function DNA binding;GO:0003824,molecular_function catalytic activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0008152,biological_process metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016874,molecular_function ligase activity;GO:0019900,molecular_function kinase binding;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032495,biological_process response to muramyl dipeptide;GO:0032691,biological_process negative regulation of interleukin-1 beta production;GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0034136,biological_process negative regulation of toll-like receptor 2 signaling pathway;GO:0034140,biological_process negative regulation of toll-like receptor 3 signaling pathway;GO:0034144,biological_process negative regulation of toll-like receptor 4 signaling pathway;GO:0034148,biological_process negative regulation of toll-like receptor 5 signaling pathway;GO:0035871,biological_process protein K11-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043621,molecular_function protein self-association;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045779,biological_process negative regulation of bone resorption;GO:0045824,biological_process negative regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050691,biological_process regulation of defense response to virus by host;GO:0050727,biological_process regulation of inflammatory response;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050869,biological_process negative regulation of B cell activation;GO:0051259,biological_process protein oligomerization;GO:0060548,biological_process negative regulation of cell death;GO:0061043,biological_process regulation of vascular wound healing;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070429,biological_process negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070433,biological_process negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071947,biological_process protein deubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0072573,biological_process tolerance induction to lipopolysaccharide;GO:0072666,biological_process establishment of protein localization to vacuole;GO:0090291,biological_process negative regulation of osteoclast proliferation;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:2000347,biological_process positive regulation of hepatocyte proliferation;GO:2000349,biological_process negative regulation of CD40 signaling pathway;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]; K11859	TNF alpha induced protein 3 [Source:HGNC Symbol%3BAcc:HGNC:11896]
ENSG00000214562	0.69	0.45	0.83	0.76	0.62	0.93	-0.195104832878294	1.00855703769068	0.469576112392986	0.806290128185973	10:87357667-87370695:+	NUTM2D	NA	NA	NUT family member 2D [Source:HGNC Symbol%3BAcc:HGNC:23447]
ENSG00000167291	8.35	10.16	8.64	9.83	8.37	7.62	0.079376302195082	4.4855055179014	0.469636063236044	0.806290128185973	17:79932342-80035848:-	TBC1D16	9;GO:0001919,biological_process regulation of receptor recycling;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 16 [Source:HGNC Symbol%3BAcc:HGNC:28356]
ENSG00000254685	8.31	7.83	8.44	7.89	9.20	9.00	-0.0710390152978577	4.06093496342571	0.46969176805871	0.806290128185973	1:74198211-74234086:+	FPGT	10;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006004,biological_process fucose metabolic process;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0047341,molecular_function fucose-1-phosphate guanylyltransferase activity	FPGT; fucose-1-phosphate guanylyltransferase [EC:2.7.7.30]; K00976	fucose-1-phosphate guanylyltransferase [Source:HGNC Symbol%3BAcc:HGNC:3825]
ENSG00000171735	6.76	6.88	6.46	6.52	6.32	6.66	0.0517064757245368	5.12569196856902	0.469782843744496	0.80633496120028	1:6785323-7769706:+	CAMTA1	12;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050885,biological_process neuromuscular process controlling balance	NA	calmodulin binding transcription activator 1 [Source:HGNC Symbol%3BAcc:HGNC:18806]
ENSG00000078795	1.61	1.09	1.18	1.17	1.18	1.13	0.191400067863686	1.34039562161928	0.469911160883087	0.806443694185228	5:137887967-137942747:+	PKD2L2	9;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050982,biological_process detection of mechanical stimulus;GO:0070588,biological_process calcium ion transmembrane transport	NA	polycystin 2 like 2%2C transient receptor potential cation channel [Source:HGNC Symbol%3BAcc:HGNC:9012]
ENSG00000196187	19.57	19.93	21.09	20.00	19.23	19.80	0.0495145247143375	5.59884562874769	0.470068481210214	0.806501342965599	1:225845535-225882369:-	TMEM63A	14;GO:0003676,molecular_function nucleic acid binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005815,cellular_component microtubule organizing center;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane	NA	transmembrane protein 63A [Source:HGNC Symbol%3BAcc:HGNC:29118]
ENSG00000204498	17.12	14.37	14.61	17.14	13.84	18.41	-0.0849514563226341	4.2529753825283	0.47008483799597	0.806501342965599	6:31546869-31558829:+	NFKBIL1	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0031665,biological_process negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0034122,biological_process negative regulation of toll-like receptor signaling pathway;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0071222,biological_process cellular response to lipopolysaccharide	NA	NFKB inhibitor like 1 [Source:HGNC Symbol%3BAcc:HGNC:7800]
ENSG00000153246	0.64	0.74	0.40	0.44	0.59	0.53	0.187467940587723	1.36388511072164	0.470139669515756	0.806501342965599	2:159932005-160062610:-	PLA2R1	22;GO:0001816,biological_process cytokine production;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0043235,cellular_component receptor complex;GO:0043274,molecular_function phospholipase binding;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0070062,cellular_component extracellular exosome;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090238,biological_process positive regulation of arachidonic acid secretion;GO:0090399,biological_process replicative senescence;GO:0090403,biological_process oxidative stress-induced premature senescence;GO:1900138,biological_process negative regulation of phospholipase A2 activity;GO:1900139,biological_process negative regulation of arachidonic acid secretion	MRC, CD206, CD280; mannose receptor, C type; K06560	phospholipase A2 receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:9042]
ENSG00000123213	13.46	12.58	15.61	16.24	12.93	15.07	-0.0718568058372452	5.04354190201033	0.470387086008357	0.806708392251859	5:65722195-65871725:+	NLN	15;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005886,cellular_component plasma membrane;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006508,biological_process proteolysis;GO:0006518,biological_process peptide metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0042277,molecular_function peptide binding;GO:0046872,molecular_function metal ion binding;GO:1902809,biological_process regulation of skeletal muscle fiber differentiation	NLN; neurolysin [EC:3.4.24.16]; K01393	neurolysin [Source:HGNC Symbol%3BAcc:HGNC:16058]
ENSG00000162521	107.44	113.85	111.39	115.12	122.11	109.40	-0.047955464090483	7.43941558032132	0.470466075361861	0.806708392251859	1:32651141-32686211:+	RBBP4	35;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016580,cellular_component Sin3 complex;GO:0016581,cellular_component NuRD complex;GO:0016589,cellular_component NURF complex;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031497,biological_process chromatin assembly;GO:0033186,cellular_component CAF-1 complex;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0035098,cellular_component ESC/E(Z) complex;GO:0042393,molecular_function histone binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0051726,biological_process regulation of cell cycle;GO:0060416,biological_process response to growth hormone;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RBBP4, HAT2, CAF1, MIS16; histone-binding protein RBBP4; K10752	RB binding protein 4%2C chromatin remodeling factor [Source:HGNC Symbol%3BAcc:HGNC:9887]
ENSG00000161011	691.62	687.98	713.43	677.47	698.14	675.76	0.0408166465493592	9.98613266804081	0.47050549349041	0.806708392251859	5:179806397-179838078:+	SQSTM1	61;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000422,biological_process mitophagy;GO:0000423,biological_process macromitophagy;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0007032,biological_process endosome organization;GO:0008104,biological_process protein localization;GO:0008270,molecular_function zinc ion binding;GO:0010821,biological_process regulation of mitochondrion organization;GO:0016197,biological_process endosomal transport;GO:0016234,cellular_component inclusion body;GO:0016235,cellular_component aggresome;GO:0016236,biological_process macroautophagy;GO:0016605,cellular_component PML body;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030154,biological_process cell differentiation;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035556,biological_process intracellular signal transduction;GO:0042169,molecular_function SH2 domain binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044130,biological_process negative regulation of growth of symbiont in host;GO:0044753,cellular_component amphisome;GO:0044754,cellular_component autolysosome;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046578,biological_process regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding;GO:0051291,biological_process protein heterooligomerization;GO:0061635,biological_process regulation of protein complex stability;GO:0070062,cellular_component extracellular exosome;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0097225,cellular_component sperm midpiece;GO:0098780,biological_process response to mitochondrial depolarisation;GO:1905719,biological_process protein localization to perinuclear region of cytoplasm	SQSTM1; sequestosome 1; K14381	sequestosome 1 [Source:HGNC Symbol%3BAcc:HGNC:11280]
ENSG00000204120	20.58	21.45	20.54	19.22	21.36	20.41	0.0478749993763575	6.38816385812722	0.470520322235033	0.806708392251859	2:232697298-232860575:+	GIGYF2	30;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007631,biological_process feeding behavior;GO:0008344,biological_process adult locomotory behavior;GO:0009791,biological_process post-embryonic development;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016441,biological_process posttranscriptional gene silencing;GO:0017148,biological_process negative regulation of translation;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0031571,biological_process mitotic G1 DNA damage checkpoint;GO:0031982,cellular_component vesicle;GO:0035264,biological_process multicellular organism growth;GO:0043204,cellular_component perikaryon;GO:0043234,cellular_component protein complex;GO:0044267,biological_process cellular protein metabolic process;GO:0045296,molecular_function cadherin binding;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050881,biological_process musculoskeletal movement;GO:0050885,biological_process neuromuscular process controlling balance;GO:0061157,biological_process mRNA destabilization;GO:0070064,molecular_function proline-rich region binding;GO:1990635,cellular_component proximal dendrite	NA	GRB10 interacting GYF protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11960]
ENSG00000142684	22.36	19.46	25.52	22.19	19.73	21.83	0.09973619931811	3.46364675327994	0.470665691746152	0.806735388380234	1:26169870-26170873:+	ZNF593	14;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0043023,molecular_function ribosomal large subunit binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1903026,biological_process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	NA	zinc finger protein 593 [Source:HGNC Symbol%3BAcc:HGNC:30943]
ENSG00000180488	13.65	11.68	13.53	12.26	13.06	12.22	0.0690521984008284	4.6081291449392	0.470666050322215	0.806735388380234	1:77779623-77879539:+	MIGA1	9;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0008053,biological_process mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0046982,molecular_function protein heterodimerization activity	NA	mitoguardin 1 [Source:HGNC Symbol%3BAcc:HGNC:24741]
ENSG00000164125	2.08	2.65	2.04	1.58	2.74	1.72	0.169047747434417	1.98484710325503	0.470924043883958	0.806804405179674	4:158124473-158173318:-	FAM198B	4;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 198 member B [Source:HGNC Symbol%3BAcc:HGNC:25312]
ENSG00000119862	4.48	3.92	4.26	5.03	3.96	5.51	-0.179746557442803	1.3758300759029	0.47092527930681	0.806804405179674	2:64453968-64461381:+	LGALSL	3;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0030246,molecular_function carbohydrate binding	NA	galectin like [Source:HGNC Symbol%3BAcc:HGNC:25012]
ENSG00000103335	27.68	25.44	28.07	28.70	25.90	30.27	-0.0514676131760373	7.73710427341583	0.470926146000767	0.806804405179674	16:88715342-88785211:-	PIEZO1	20;GO:0005261,molecular_function cation channel activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0008381,molecular_function mechanically-gated ion channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031258,cellular_component lamellipodium membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0033625,biological_process positive regulation of integrin activation;GO:0033634,biological_process positive regulation of cell-cell adhesion mediated by integrin;GO:0034220,biological_process ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0042995,cellular_component cell projection;GO:0050982,biological_process detection of mechanical stimulus;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0098655,biological_process cation transmembrane transport	NA	piezo type mechanosensitive ion channel component 1 [Source:HGNC Symbol%3BAcc:HGNC:28993]
ENSG00000137812	5.03	5.48	4.23	4.58	5.78	5.28	-0.0779472526565764	5.15742294567267	0.471129283531915	0.806804405179674	15:40594019-40664342:+	KNL1	21;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001669,cellular_component acrosomal vesicle;GO:0001675,biological_process acrosome assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016604,cellular_component nuclear body;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0034501,biological_process protein localization to kinetochore;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0071173,biological_process spindle assembly checkpoint	NA	kinetochore scaffold 1 [Source:HGNC Symbol%3BAcc:HGNC:24054]
ENSG00000120616	7.37	7.46	7.03	7.19	6.98	9.16	-0.0849748525073289	4.25498215352692	0.471166009262102	0.806804405179674	10:32267750-32378798:-	EPC1	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016569,biological_process covalent chromatin modification;GO:0031965,cellular_component nuclear membrane;GO:0032777,cellular_component Piccolo NuA4 histone acetyltransferase complex;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0035886,biological_process vascular smooth muscle cell differentiation;GO:0040008,biological_process regulation of growth;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	enhancer of polycomb homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:19876]
ENSG00000198740	4.74	4.73	4.13	4.24	4.63	3.91	0.100227580776738	3.02268563655649	0.471185865486709	0.806804405179674	17:49289205-49362473:-	ZNF652	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 652 [Source:HGNC Symbol%3BAcc:HGNC:29147]
ENSG00000170264	5.39	5.38	4.44	5.91	5.08	5.30	-0.0913305845849356	3.58338563273368	0.471241586051806	0.806804405179674	2:61824853-61854143:-	FAM161A	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007601,biological_process visual perception;GO:0030030,biological_process cell projection organization;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0036064,cellular_component ciliary basal body;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0050896,biological_process response to stimulus;GO:0060271,biological_process cilium morphogenesis	NA	family with sequence similarity 161 member A [Source:HGNC Symbol%3BAcc:HGNC:25808]
ENSG00000166170	31.98	30.94	31.62	32.73	32.69	33.14	-0.0470815567703862	5.56445639384718	0.471266950791772	0.806804405179674	14:103556543-103562831:-	BAG5	23;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0007030,biological_process Golgi organization;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0019901,molecular_function protein kinase binding;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051087,molecular_function chaperone binding;GO:0051438,biological_process regulation of ubiquitin-protein transferase activity;GO:0051444,biological_process negative regulation of ubiquitin-protein transferase activity;GO:0061084,biological_process negative regulation of protein refolding;GO:0070997,biological_process neuron death;GO:0090083,biological_process regulation of inclusion body assembly;GO:1900034,biological_process regulation of cellular response to heat;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	NA	BCL2 associated athanogene 5 [Source:HGNC Symbol%3BAcc:HGNC:941]
ENSG00000109118	14.90	13.82	14.69	14.50	14.49	13.29	0.0530647534489367	5.65211539972173	0.471336509765571	0.806804405179674	17:28905249-28951771:-	PHF12	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001222,molecular_function transcription corepressor binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016580,cellular_component Sin3 complex;GO:0017053,cellular_component transcriptional repressor complex;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042393,molecular_function histone binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	PHD finger protein 12 [Source:HGNC Symbol%3BAcc:HGNC:20816]
ENSG00000134369	15.78	15.01	17.27	17.90	15.47	16.96	-0.0539760478654045	6.73877731820277	0.47139121182177	0.806804405179674	1:201622884-201826969:+	NAV1	10;GO:0001578,biological_process microtubule bundle formation;GO:0001764,biological_process neuron migration;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030154,biological_process cell differentiation;GO:0043194,cellular_component axon initial segment	NA	neuron navigator 1 [Source:HGNC Symbol%3BAcc:HGNC:15989]
ENSG00000186666	12.66	12.55	14.70	15.56	14.20	13.08	-0.0853180678587045	3.61552615248851	0.47172160171463	0.806804405179674	12:49836038-49843129:-	BCDIN3D	12;GO:0001510,biological_process RNA methylation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008168,molecular_function methyltransferase activity;GO:0008171,molecular_function O-methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0010586,biological_process miRNA metabolic process;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:2000632,biological_process negative regulation of pre-miRNA processing	NA	BCDIN3 domain containing RNA methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:27050]
ENSG00000180596	3.74	5.06	3.70	4.95	5.02	4.65	-0.236939043194588	0.887606291881989	0.47172203384385	0.806804405179674	6:26114872-26123926:-	HIST1H2BC	17;GO:0000786,cellular_component nucleosome;GO:0002227,biological_process innate immune response in mucosa;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006334,biological_process nucleosome assembly;GO:0016567,biological_process protein ubiquitination;GO:0019731,biological_process antibacterial humoral response;GO:0042742,biological_process defense response to bacterium;GO:0046982,molecular_function protein heterodimerization activity;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070062,cellular_component extracellular exosome	NA	histone cluster 1 H2B family member c [Source:HGNC Symbol%3BAcc:HGNC:4757]
ENSG00000029639	28.03	26.61	28.50	31.02	27.98	28.38	-0.0568887933698827	4.89246427868735	0.471738308756201	0.806804405179674	6:155257508-155314493:-	TFB1M	17;GO:0000154,biological_process rRNA modification;GO:0000179,molecular_function rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0007005,biological_process mitochondrion organization;GO:0008168,molecular_function methyltransferase activity;GO:0008649,molecular_function rRNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0042645,cellular_component mitochondrial nucleoid	NA	transcription factor B1%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:17037]
ENSG00000250571	15.71	16.94	18.14	18.65	17.18	17.66	-0.0642241026703044	4.67602647884326	0.471745058757555	0.806804405179674	8:143267432-143276931:+	GLI4	8;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	GLI family zinc finger 4 [Source:HGNC Symbol%3BAcc:HGNC:4320]
ENSG00000080345	11.48	11.83	11.81	11.30	13.54	11.92	-0.0541828690586296	6.49137322356419	0.471792907344843	0.806804405179674	2:151409882-151508013:+	RIF1	31;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000790,cellular_component nuclear chromatin;GO:0000793,cellular_component condensed chromosome;GO:0001939,cellular_component female pronucleus;GO:0001940,cellular_component male pronucleus;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006348,biological_process chromatin silencing at telomere;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0016604,cellular_component nuclear body;GO:0019827,biological_process stem cell population maintenance;GO:0031965,cellular_component nuclear membrane;GO:0035861,cellular_component site of double-strand break;GO:0043247,biological_process telomere maintenance in response to DNA damage;GO:0045830,biological_process positive regulation of isotype switching;GO:0051233,cellular_component spindle midzone;GO:0051574,biological_process positive regulation of histone H3-K9 methylation;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination;GO:2001034,biological_process positive regulation of double-strand break repair via nonhomologous end joining	RIF1; telomere-associated protein RIF1; K11138	replication timing regulatory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:23207]
ENSG00000186665	6.94	6.12	6.79	7.49	6.66	7.28	-0.0916713827630908	3.00413425295094	0.471822591958344	0.806804405179674	17:67991100-67996431:-	C17orf58	1;GO:0005576,cellular_component extracellular region	NA	chromosome 17 open reading frame 58 [Source:HGNC Symbol%3BAcc:HGNC:27568]
ENSG00000169019	53.64	60.58	51.88	51.55	58.30	49.82	0.0641745394672608	4.9020132877432	0.471832412518962	0.806804405179674	4:47450795-47463719:-	COMMD8	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	COMM domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:26036]
ENSG00000186472	0.40	0.37	0.42	0.24	0.43	0.41	0.150720427122549	2.60941695719796	0.4718798247165	0.806804405179674	7:82754012-83162930:-	PCLO	22;GO:0005509,molecular_function calcium ion binding;GO:0005522,molecular_function profilin binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0007416,biological_process synapse assembly;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0017157,biological_process regulation of exocytosis;GO:0019933,biological_process cAMP-mediated signaling;GO:0030054,cellular_component cell junction;GO:0030073,biological_process insulin secretion;GO:0035418,biological_process protein localization to synapse;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0048786,cellular_component presynaptic active zone;GO:0048788,cellular_component cytoskeleton of presynaptic active zone;GO:0070062,cellular_component extracellular exosome;GO:0098831,cellular_component presynaptic active zone cytoplasmic component;GO:0099526,biological_process presynapse to nucleus signaling pathway	PCLO; protein piccolo; K16882	piccolo presynaptic cytomatrix protein [Source:HGNC Symbol%3BAcc:HGNC:13406]
ENSG00000074319	70.57	67.19	73.48	72.84	70.45	77.04	-0.047852207069047	6.41410075376716	0.471941254008669	0.806804405179674	11:18468335-18527232:-	TSG101	64;GO:0000813,cellular_component ESCRT I complex;GO:0001558,biological_process regulation of cell growth;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0006513,biological_process protein monoubiquitination;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008333,biological_process endosome to lysosome transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0030154,biological_process cell differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030496,cellular_component midbody;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0032403,molecular_function protein complex binding;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0040008,biological_process regulation of growth;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043405,biological_process regulation of MAP kinase activity;GO:0043657,cellular_component host cell;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046755,biological_process viral budding;GO:0046790,molecular_function virion binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048524,biological_process positive regulation of viral process;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus;GO:0097352,biological_process autophagosome maturation;GO:1902188,biological_process positive regulation of viral release from host cell;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903551,biological_process regulation of extracellular exosome assembly;GO:1903772,biological_process regulation of viral budding via host ESCRT complex;GO:1903774,biological_process positive regulation of viral budding via host ESCRT complex;GO:1990182,biological_process exosomal secretion;GO:2000397,biological_process positive regulation of ubiquitin-dependent endocytosis	TSG101, STP22, VPS23; ESCRT-I complex subunit TSG101; K12183	tumor susceptibility 101 [Source:HGNC Symbol%3BAcc:HGNC:15971]
ENSG00000086062	109.61	102.61	103.32	111.23	107.33	109.71	-0.0446259057280677	7.03657006581127	0.472138545526909	0.806818579776191	9:33104081-33167356:-	B4GALT1	58;GO:0000138,cellular_component Golgi trans cisterna;GO:0000139,cellular_component Golgi membrane;GO:0002064,biological_process epithelial cell development;GO:0002526,biological_process acute inflammatory response;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945,molecular_function N-acetyllactosamine synthase activity;GO:0004461,molecular_function lactose synthase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0005989,biological_process lactose biosynthetic process;GO:0006012,biological_process galactose metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0007155,biological_process cell adhesion;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0007341,biological_process penetration of zona pellucida;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008378,molecular_function galactosyltransferase activity;GO:0009101,biological_process glycoprotein biosynthetic process;GO:0009312,biological_process oligosaccharide biosynthetic process;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0030057,cellular_component desmosome;GO:0030145,molecular_function manganese ion binding;GO:0030175,cellular_component filopodium;GO:0030198,biological_process extracellular matrix organization;GO:0030667,cellular_component secretory granule membrane;GO:0030879,biological_process mammary gland development;GO:0031526,cellular_component brush border membrane;GO:0032580,cellular_component Golgi cisterna membrane;GO:0035250,molecular_function UDP-galactosyltransferase activity;GO:0035577,cellular_component azurophil granule membrane;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0045136,biological_process development of secondary sexual characteristics;GO:0046872,molecular_function metal ion binding;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0050900,biological_process leukocyte migration;GO:0051260,biological_process protein homooligomerization;GO:0051270,biological_process regulation of cellular component movement;GO:0060046,biological_process regulation of acrosome reaction;GO:0060054,biological_process positive regulation of epithelial cell proliferation involved in wound healing;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0060058,biological_process positive regulation of apoptotic process involved in mammary gland involution;GO:0070062,cellular_component extracellular exosome	B4GALT1; beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]; K07966	beta-1%2C4-galactosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:924]
ENSG00000112234	17.89	15.24	16.55	17.24	16.85	18.19	-0.0567987754537536	4.9955460441123	0.472225300090307	0.806818579776191	6:98868537-98948006:-	FBXL4	11;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016607,cellular_component nuclear speck;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 4 [Source:HGNC Symbol%3BAcc:HGNC:13601]
ENSG00000142959	0.70	1.01	0.93	1.11	1.02	0.99	-0.243339675662065	0.592382300337197	0.472231561428737	0.806818579776191	1:44783584-44787705:-	BEST4	11;GO:0003674,molecular_function molecular_function;GO:0005254,molecular_function chloride channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034707,cellular_component chloride channel complex;GO:1902476,biological_process chloride transmembrane transport	NA	bestrophin 4 [Source:HGNC Symbol%3BAcc:HGNC:17106]
ENSG00000156482	1947.93	1791.99	1911.08	2082.13	1792.38	2025.41	-0.0502789448286446	9.38090569024583	0.472231720550666	0.806818579776191	8:98024850-98046469:-	RPL30	23;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0031640,biological_process killing of cells of other organism;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein L30 [Source:HGNC Symbol%3BAcc:HGNC:10333]
ENSG00000133313	166.88	171.76	171.42	173.96	176.91	178.24	-0.0412738795393952	8.40422703088313	0.472274534814614	0.806818579776191	18:74495815-74523454:+	CNDP2	15;GO:0004180,molecular_function carboxypeptidase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006750,biological_process glutathione biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016805,molecular_function dipeptidase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0102008,molecular_function cytosolic dipeptidase activity;GO:0103046,molecular_function alanylglutamate dipeptidase activity	CNDP2; cytosolic nonspecific dipeptidase [EC:3.4.13.18]; K08660	carnosine dipeptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:24437]
ENSG00000115839	31.64	29.91	30.20	31.76	31.17	32.59	-0.0456952210793643	6.5666858882518	0.472427863232199	0.806969460066229	2:135052264-135176394:+	RAB3GAP1	31;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0007420,biological_process brain development;GO:0010628,biological_process positive regulation of gene expression;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0021854,biological_process hypothalamus development;GO:0034389,biological_process lipid particle organization;GO:0043010,biological_process camera-type eye development;GO:0043087,biological_process regulation of GTPase activity;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060325,biological_process face morphogenesis;GO:0061024,biological_process membrane organization;GO:0061646,biological_process positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization;GO:0070062,cellular_component extracellular exosome;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0097051,biological_process establishment of protein localization to endoplasmic reticulum membrane;GO:0098794,cellular_component postsynapse;GO:1903061,biological_process positive regulation of protein lipidation;GO:1903233,biological_process regulation of calcium ion-dependent exocytosis of neurotransmitter;GO:1903373,biological_process positive regulation of endoplasmic reticulum tubular network organization;GO:2000786,biological_process positive regulation of autophagosome assembly	NA	RAB3 GTPase activating protein catalytic subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:17063]
ENSG00000137221	16.56	16.53	15.24	17.21	16.74	16.63	-0.0557865377494187	5.02569746230493	0.472659399035952	0.807253869046955	6:43477522-43506556:+	TJAP1	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007030,biological_process Golgi organization;GO:0030054,cellular_component cell junction	TJP4, PILT; tight junction protein 4; K06105	tight junction associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17949]
ENSG00000136982	9.28	8.67	6.80	7.94	9.01	9.90	-0.108269599314521	3.36539063450009	0.472910817894281	0.807335939794876	8:119833975-119856010:-	DSCC1	16;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006275,biological_process regulation of DNA replication;GO:0007049,biological_process cell cycle;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0034088,biological_process maintenance of mitotic sister chromatid cohesion;GO:0034421,biological_process post-translational protein acetylation;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:1900264,biological_process positive regulation of DNA-directed DNA polymerase activity	NA	DNA replication and sister chromatid cohesion 1 [Source:HGNC Symbol%3BAcc:HGNC:24453]
ENSG00000135870	4.05	3.74	3.33	4.45	4.08	3.43	-0.0911824251097035	3.72683543139767	0.472972324891603	0.807335939794876	1:173931213-174022297:-	RC3H1	34;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0001782,biological_process B cell homeostasis;GO:0002634,biological_process regulation of germinal center formation;GO:0002635,biological_process negative regulation of germinal center formation;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005737,cellular_component cytoplasm;GO:0010468,biological_process regulation of gene expression;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0016567,biological_process protein ubiquitination;GO:0030889,biological_process negative regulation of B cell proliferation;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0035613,molecular_function RNA stem-loop binding;GO:0042098,biological_process T cell proliferation;GO:0042129,biological_process regulation of T cell proliferation;GO:0043029,biological_process T cell homeostasis;GO:0043488,biological_process regulation of mRNA stability;GO:0045623,biological_process negative regulation of T-helper cell differentiation;GO:0046007,biological_process negative regulation of activated T cell proliferation;GO:0046872,molecular_function metal ion binding;GO:0048535,biological_process lymph node development;GO:0048536,biological_process spleen development;GO:0050856,biological_process regulation of T cell receptor signaling pathway;GO:0050863,biological_process regulation of T cell activation;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0061470,biological_process T follicular helper cell differentiation;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071347,biological_process cellular response to interleukin-1;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling	NA	ring finger and CCCH-type domains 1 [Source:HGNC Symbol%3BAcc:HGNC:29434]
ENSG00000140598	8.30	7.94	8.46	7.35	8.22	8.33	0.0608843516202424	4.77591126952289	0.472994234961541	0.807335939794876	15:82130229-82262763:-	EFL1	10;GO:0000166,molecular_function nucleotide binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0042254,biological_process ribosome biogenesis;GO:0042256,biological_process mature ribosome assembly;GO:0043022,molecular_function ribosome binding;GO:0046039,biological_process GTP metabolic process	RIA1; ribosome assembly protein 1 [EC:3.6.5.-]; K14536	elongation factor like GTPase 1 [Source:HGNC Symbol%3BAcc:HGNC:25789]
ENSG00000101150	76.03	75.33	75.57	77.64	82.42	76.33	-0.0465004520154001	5.92447679012112	0.473022331890062	0.807335939794876	20:63865227-63891545:+	TPD52L2	2;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding	NA	tumor protein D52 like 2 [Source:HGNC Symbol%3BAcc:HGNC:12007]
ENSG00000118508	82.45	69.52	75.78	77.31	75.95	85.84	-0.0550581478388789	5.72233356363505	0.473091257465102	0.807335939794876	6:146543692-146554965:+	RAB32	31;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0007005,biological_process mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019882,biological_process antigen processing and presentation;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0033162,cellular_component melanosome membrane;GO:0035646,biological_process endosome to melanosome transport;GO:0035650,molecular_function AP-1 adaptor complex binding;GO:0035651,molecular_function AP-3 adaptor complex binding;GO:0036461,molecular_function BLOC-2 complex binding;GO:0042470,cellular_component melanosome;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0045335,cellular_component phagocytic vesicle;GO:0061024,biological_process membrane organization;GO:0072657,biological_process protein localization to membrane;GO:0090382,biological_process phagosome maturation;GO:1903232,biological_process melanosome assembly	NA	RAB32%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9772]
ENSG00000188735	8.74	9.05	8.35	7.35	8.15	9.18	0.0889138913083207	3.33246584301908	0.473157279703143	0.807335939794876	12:121712751-121783001:+	TMEM120B	10;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045444,biological_process fat cell differentiation;GO:0051291,biological_process protein heterooligomerization	NA	transmembrane protein 120B [Source:HGNC Symbol%3BAcc:HGNC:32008]
ENSG00000134982	4.05	4.19	3.80	4.09	4.52	4.01	-0.058168440212553	5.17954986400687	0.473286160517803	0.807335939794876	5:112707497-112846239:+	APC	62;GO:0000281,biological_process mitotic cytokinesis;GO:0000776,cellular_component kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005923,cellular_component bicellular tight junction;GO:0006461,biological_process protein complex assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007050,biological_process cell cycle arrest;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0007155,biological_process cell adhesion;GO:0008013,molecular_function beta-catenin binding;GO:0008017,molecular_function microtubule binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016328,cellular_component lateral plasma membrane;GO:0016342,cellular_component catenin complex;GO:0016477,biological_process cell migration;GO:0016579,biological_process protein deubiquitination;GO:0019887,molecular_function protein kinase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030335,biological_process positive regulation of cell migration;GO:0030877,cellular_component beta-catenin destruction complex;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032587,cellular_component ruffle membrane;GO:0032886,biological_process regulation of microtubule-based process;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045295,molecular_function gamma-catenin binding;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051010,molecular_function microtubule plus-end binding;GO:0051260,biological_process protein homooligomerization;GO:0051988,biological_process regulation of attachment of spindle microtubules to kinetochore;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0070830,biological_process bicellular tight junction assembly;GO:0070840,molecular_function dynein complex binding;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097194,biological_process execution phase of apoptosis;GO:1904781,biological_process positive regulation of protein localization to centrosome;GO:1904885,biological_process beta-catenin destruction complex assembly;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:1990909,cellular_component Wnt signalosome	APC; adenomatosis polyposis coli protein; K02085	APC%2C WNT signaling pathway regulator [Source:HGNC Symbol%3BAcc:HGNC:583]
ENSG00000114735	22.36	23.18	27.07	22.89	20.42	26.07	0.077421280820965	4.59613928077464	0.473362880848987	0.807335939794876	3:50569151-50596168:+	HEMK1	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006306,biological_process DNA methylation;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0008170,molecular_function N-methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	HemK methyltransferase family member 1 [Source:HGNC Symbol%3BAcc:HGNC:24923]
ENSG00000122565	514.42	501.04	477.62	506.98	528.21	515.79	-0.0431703052435862	8.16224754529235	0.473434822342971	0.807335939794876	7:26201161-26213356:+	CBX3	22;GO:0000775,cellular_component chromosome, centromeric region;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005719,cellular_component nuclear euchromatin;GO:0005720,cellular_component nuclear heterochromatin;GO:0005819,cellular_component spindle;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0042802,molecular_function identical protein binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:1990226,molecular_function histone methyltransferase binding	CBX3, HP1G; chromobox protein 3; K11586	chromobox 3 [Source:HGNC Symbol%3BAcc:HGNC:1553]
ENSG00000153310	86.48	86.60	86.16	96.17	87.27	86.81	-0.0482181727235539	6.46985219748244	0.473521647812139	0.807335939794876	8:129839592-130017129:-	FAM49B	12;GO:0001916,biological_process positive regulation of T cell mediated cytotoxicity;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005929,cellular_component cilium;GO:0016020,cellular_component membrane;GO:0023030,molecular_function MHC class Ib protein binding, via antigen binding groove;GO:0031093,cellular_component platelet alpha granule lumen;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0050870,biological_process positive regulation of T cell activation;GO:0070062,cellular_component extracellular exosome;GO:2000568,biological_process positive regulation of memory T cell activation	NA	family with sequence similarity 49 member B [Source:HGNC Symbol%3BAcc:HGNC:25216]
ENSG00000144061	8.95	7.35	9.14	8.44	7.83	8.21	0.0761933429505114	4.35429473003494	0.473547061330666	0.807335939794876	2:110122310-110205066:-	NPHP1	26;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005923,cellular_component bicellular tight junction;GO:0005929,cellular_component cilium;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0007588,biological_process excretion;GO:0007632,biological_process visual behavior;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030030,biological_process cell projection organization;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0031514,cellular_component motile cilium;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0042995,cellular_component cell projection;GO:0048515,biological_process spermatid differentiation;GO:0060041,biological_process retina development in camera-type eye;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1903348,biological_process positive regulation of bicellular tight junction assembly	NA	nephrocystin 1 [Source:HGNC Symbol%3BAcc:HGNC:7905]
ENSG00000155970	1.31	1.31	2.46	2.14	1.67	2.01	-0.175564949418094	1.69035139145257	0.473631836038036	0.807335939794876	8:17027237-17122644:+	MICU3	7;GO:0005509,molecular_function calcium ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	mitochondrial calcium uptake family member 3 [Source:HGNC Symbol%3BAcc:HGNC:27820]
ENSG00000139624	18.16	19.57	18.63	19.43	20.12	19.38	-0.0554409569156691	5.06812311136707	0.473693189903293	0.807335939794876	12:50129305-50167533:-	CERS5	13;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0031965,cellular_component nuclear membrane;GO:0046513,biological_process ceramide biosynthetic process;GO:0050291,molecular_function sphingosine N-acyltransferase activity	CERS1_2_3_4, LASS1_2_3_4; ceramide synthetase [EC:2.3.1.24]; K04710	ceramide synthase 5 [Source:HGNC Symbol%3BAcc:HGNC:23749]
ENSG00000188033	1.50	1.27	1.20	1.27	1.28	0.94	0.208222550931756	1.14042191943183	0.473753430682439	0.807335939794876	19:12577960-12640098:-	ZNF490	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 490 [Source:HGNC Symbol%3BAcc:HGNC:23705]
ENSG00000197217	10.65	9.77	10.64	10.60	9.07	10.26	0.0682986737109549	4.4170625709961	0.473766339098066	0.807335939794876	8:23385782-23457695:-	ENTPD4	14;GO:0000139,cellular_component Golgi membrane;GO:0000421,cellular_component autophagosome membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006256,biological_process UDP catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0030173,cellular_component integral component of Golgi membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0045134,molecular_function uridine-diphosphatase activity;GO:0097637,cellular_component integral component of autophagosome membrane	ENTPD4, LALP70; ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6]; K12305	ectonucleoside triphosphate diphosphohydrolase 4 [Source:HGNC Symbol%3BAcc:HGNC:14573]
ENSG00000143740	22.42	19.29	20.10	19.54	20.76	19.61	0.0618964185312537	4.98969111742773	0.47376844135407	0.807335939794876	1:227728538-227781231:+	SNAP47	17;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016082,biological_process synaptic vesicle priming;GO:0019905,molecular_function syntaxin binding;GO:0030425,cellular_component dendrite;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031083,cellular_component BLOC-1 complex;GO:0031201,cellular_component SNARE complex;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0043025,cellular_component neuronal cell body;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060291,biological_process long-term synaptic potentiation;GO:0098967,biological_process exocytic insertion of neurotransmitter receptor to postsynaptic membrane	SNAP29; synaptosomal-associated protein 29; K08509	synaptosome associated protein 47 [Source:HGNC Symbol%3BAcc:HGNC:30669]
ENSG00000234127	20.79	21.81	17.89	22.04	21.90	19.74	-0.0660319173594268	5.0699554137355	0.473813125062891	0.807335939794876	6:30184454-30213427:-	TRIM26	13;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0045087,biological_process innate immune response;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:1902187,biological_process negative regulation of viral release from host cell	NA	tripartite motif containing 26 [Source:HGNC Symbol%3BAcc:HGNC:12962]
ENSG00000182870	6.33	6.35	7.28	6.89	5.83	6.27	0.0869065193548834	3.73881657331035	0.473955532057862	0.807382309009495	12:132196371-132329349:-	GALNT9	12;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 9 [Source:HGNC Symbol%3BAcc:HGNC:4131]
ENSG00000196704	76.80	70.42	77.04	84.15	68.50	82.91	-0.0581643501293219	6.50082337623204	0.473970425018303	0.807382309009495	17:68247573-68257164:+	AMZ2	7;GO:0005575,cellular_component cellular_component;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	archaelysin family metallopeptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:28041]
ENSG00000165525	22.10	23.32	21.69	19.10	23.78	22.11	0.0566412541246458	6.15680434248051	0.474042782069132	0.807394765892445	14:49782082-49853203:-	NEMF	2;GO:0005634,cellular_component nucleus;GO:0051168,biological_process nuclear export	NA	nuclear export mediator factor [Source:HGNC Symbol%3BAcc:HGNC:10663]
ENSG00000169750	17.53	15.76	17.51	16.90	14.22	16.97	0.0955565101194883	3.27363032905929	0.47414746246329	0.807430866359466	17:82031623-82034204:+	RAC3	36;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0012505,cellular_component endomembrane system;GO:0014041,biological_process regulation of neuron maturation;GO:0016020,cellular_component membrane;GO:0021894,biological_process cerebral cortex GABAergic interneuron development;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030027,cellular_component lamellipodium;GO:0030031,biological_process cell projection assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030426,cellular_component growth cone;GO:0031175,biological_process neuron projection development;GO:0031941,cellular_component filamentous actin;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050885,biological_process neuromuscular process controlling balance;GO:0050905,biological_process neuromuscular process;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051932,biological_process synaptic transmission, GABAergic;GO:0070062,cellular_component extracellular exosome;GO:0071944,cellular_component cell periphery;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	NA	ras-related C3 botulinum toxin substrate 3 (rho family%2C small GTP binding protein Rac3) [Source:HGNC Symbol%3BAcc:HGNC:9803]
ENSG00000104980	40.36	35.32	40.05	37.82	36.96	38.02	0.0529899073199619	5.80473409304513	0.474226384797151	0.807430866359466	19:7926717-7943920:-	TIMM44	12;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0051087,molecular_function chaperone binding	NA	translocase of inner mitochondrial membrane 44 [Source:HGNC Symbol%3BAcc:HGNC:17316]
ENSG00000139197	16.96	18.59	17.71	17.90	19.10	18.64	-0.0553272132793115	5.21680469802557	0.47425911919978	0.807430866359466	12:7188684-7218574:+	PEX5	34;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0000268,molecular_function peroxisome targeting sequence binding;GO:0001764,biological_process neuron migration;GO:0005052,molecular_function peroxisome matrix targeting signal-1 binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0007005,biological_process mitochondrion organization;GO:0007006,biological_process mitochondrial membrane organization;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007031,biological_process peroxisome organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016558,biological_process protein import into peroxisome matrix;GO:0016560,biological_process protein import into peroxisome matrix, docking;GO:0016567,biological_process protein ubiquitination;GO:0019899,molecular_function enzyme binding;GO:0021795,biological_process cerebral cortex cell migration;GO:0021895,biological_process cerebral cortex neuron differentiation;GO:0031267,molecular_function small GTPase binding;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0043234,cellular_component protein complex;GO:0044255,biological_process cellular lipid metabolic process;GO:0045046,biological_process protein import into peroxisome membrane;GO:0047485,molecular_function protein N-terminus binding;GO:0048468,biological_process cell development;GO:0050905,biological_process neuromuscular process;GO:1901094,biological_process negative regulation of protein homotetramerization	PEX5, PXR1; peroxin-5; K13342	peroxisomal biogenesis factor 5 [Source:HGNC Symbol%3BAcc:HGNC:9719]
ENSG00000177885	96.45	105.11	91.00	98.84	94.78	90.45	0.0513762363106099	6.03477827566836	0.474327849391601	0.807437135833508	17:75318075-75405709:-	GRB2	73;GO:0000165,biological_process MAPK cascade;GO:0001784,molecular_function phosphotyrosine binding;GO:0003723,molecular_function RNA binding;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005168,molecular_function neurotrophin TRKA receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007411,biological_process axon guidance;GO:0007568,biological_process aging;GO:0008180,cellular_component COP9 signalosome;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009967,biological_process positive regulation of signal transduction;GO:0012506,cellular_component vesicle membrane;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016477,biological_process cell migration;GO:0017124,molecular_function SH3 domain binding;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031295,biological_process T cell costimulation;GO:0031623,biological_process receptor internalization;GO:0035635,biological_process entry of bacterium into host cell;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0043408,biological_process regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043560,molecular_function insulin receptor substrate binding;GO:0045087,biological_process innate immune response;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046875,molecular_function ephrin receptor binding;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0050900,biological_process leukocyte migration;GO:0051219,molecular_function phosphoprotein binding;GO:0051291,biological_process protein heterooligomerization;GO:0060670,biological_process branching involved in labyrinthine layer morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070436,cellular_component Grb2-EGFR complex;GO:0071479,biological_process cellular response to ionizing radiation;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	GRB2; growth factor receptor-binding protein 2; K04364	growth factor receptor bound protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4566]
ENSG00000182541	5.77	6.08	5.70	6.18	6.52	5.89	-0.0737401680695908	3.85288672938416	0.474699304772092	0.807933111479157	22:31212238-31280080:+	LIMK2	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005801,cellular_component cis-Golgi network;GO:0006468,biological_process protein phosphorylation;GO:0007283,biological_process spermatogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042325,biological_process regulation of phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	LIMK2; LIM domain kinase 2 [EC:2.7.11.1]; K05744	LIM domain kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6614]
ENSG00000266074	1.17	1.24	1.10	0.91	1.06	1.30	0.106610784294232	3.18350182995726	0.474754127144651	0.807933111479157	17:81395474-81466332:+	BAHCC1	1;GO:0003682,molecular_function chromatin binding	NA	BAH domain and coiled-coil containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29279]
ENSG00000185722	15.12	15.04	14.49	14.97	15.74	15.79	-0.0473542105482043	5.7969193145797	0.474814472588452	0.807933111479157	17:4163906-4263977:-	ANKFY1	21;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030904,cellular_component retromer complex;GO:0032439,biological_process endosome localization;GO:0034058,biological_process endosomal vesicle fusion;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044354,cellular_component macropinosome;GO:0046872,molecular_function metal ion binding;GO:0048549,biological_process positive regulation of pinocytosis;GO:0070062,cellular_component extracellular exosome;GO:0090160,biological_process Golgi to lysosome transport;GO:1901981,molecular_function phosphatidylinositol phosphate binding	NA	ankyrin repeat and FYVE domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20763]
ENSG00000154914	4.89	4.15	5.33	5.01	4.01	4.67	0.088699325731632	4.04340710201503	0.474921775508474	0.808004934126464	17:9644697-9729691:+	USP43	12;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019785,molecular_function ISG15-specific protease activity;GO:0019985,biological_process translesion synthesis;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 43 [Source:HGNC Symbol%3BAcc:HGNC:20072]
ENSG00000024862	27.75	27.20	30.26	28.51	27.77	26.01	0.0659535580019498	4.53105726577662	0.475178642331823	0.808309895888121	6:138773508-138793319:+	CCDC28A	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 28A [Source:HGNC Symbol%3BAcc:HGNC:21098]
ENSG00000151490	0.48	0.52	0.44	0.47	0.85	0.40	-0.239250071579067	1.05535672227887	0.475232798258898	0.808309895888121	12:15322396-15597399:+	PTPRO	36;GO:0000902,biological_process cell morphogenesis;GO:0002548,biological_process monocyte chemotaxis;GO:0003093,biological_process regulation of glomerular filtration;GO:0003105,biological_process negative regulation of glomerular filtration;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007411,biological_process axon guidance;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017147,molecular_function Wnt-protein binding;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0032835,biological_process glomerulus development;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0036060,biological_process slit diaphragm assembly;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043197,cellular_component dendritic spine;GO:0070062,cellular_component extracellular exosome;GO:0072112,biological_process glomerular visceral epithelial cell differentiation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090260,biological_process negative regulation of retinal ganglion cell axon guidance	NA	protein tyrosine phosphatase%2C receptor type O [Source:HGNC Symbol%3BAcc:HGNC:9678]
ENSG00000146872	18.23	18.15	18.22	19.76	17.67	19.62	-0.0520488203985017	5.48168073672765	0.47529637719225	0.808309895888121	17:62458657-62615481:+	TLK2	24;GO:0000166,molecular_function nucleotide binding;GO:0001672,biological_process regulation of chromatin assembly or disassembly;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0010507,biological_process negative regulation of autophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035556,biological_process intracellular signal transduction;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071480,biological_process cellular response to gamma radiation	NA	tousled like kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:11842]
ENSG00000101966	17.38	17.56	14.91	16.52	17.75	18.25	-0.0674610847459403	4.67777476224695	0.475416400832096	0.808403258017646	X:123859723-123913979:+	XIAP	30;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010466,biological_process negative regulation of peptidase activity;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030510,biological_process regulation of BMP signaling pathway;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045088,biological_process regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050727,biological_process regulation of inflammatory response;GO:0055070,biological_process copper ion homeostasis;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070424,biological_process regulation of nucleotide-binding oligomerization domain containing signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902530,biological_process positive regulation of protein linear polyubiquitination;GO:1990001,biological_process inhibition of cysteine-type endopeptidase activity involved in apoptotic process	XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]; K04725	X-linked inhibitor of apoptosis [Source:HGNC Symbol%3BAcc:HGNC:592]
ENSG00000131389	248.82	233.49	257.50	241.88	243.79	238.13	0.043619757347147	9.0482936325979	0.475717926211527	0.808518803762442	3:14402575-14489349:+	SLC6A6	20;GO:0003333,biological_process amino acid transmembrane transport;GO:0005328,molecular_function neurotransmitter:sodium symporter activity;GO:0005368,molecular_function taurine transmembrane transporter activity;GO:0005369,molecular_function taurine:sodium symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015711,biological_process organic anion transport;GO:0015734,biological_process taurine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042918,biological_process alkanesulfonate transport;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport;GO:1903825,biological_process organic acid transmembrane transport	NA	solute carrier family 6 member 6 [Source:HGNC Symbol%3BAcc:HGNC:11052]
ENSG00000197363	5.21	5.43	6.72	5.25	5.54	5.57	0.0996575888114006	3.24205627656355	0.475748649254756	0.808518803762442	8:144798875-144811169:+	ZNF517	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 517 [Source:HGNC Symbol%3BAcc:HGNC:27984]
ENSG00000118816	210.88	195.34	219.58	217.96	211.07	222.41	-0.0453694073166336	8.00262918732593	0.47583071371138	0.808518803762442	4:77047157-77076005:-	CCNI	2;GO:0007283,biological_process spermatogenesis;GO:0051726,biological_process regulation of cell cycle	NA	cyclin I [Source:HGNC Symbol%3BAcc:HGNC:1595]
ENSG00000166896	9.67	10.49	10.97	10.04	12.43	11.15	-0.101200384573997	3.02151726179995	0.475833542107437	0.808518803762442	12:57941540-57957269:+	ATP23	12;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004677,molecular_function DNA-dependent protein kinase activity;GO:0005886,cellular_component plasma membrane;GO:0005958,cellular_component DNA-dependent protein kinase-DNA ligase 4 complex;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006468,biological_process protein phosphorylation;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	NA	ATP23 metallopeptidase and ATP synthase assembly factor homolog [Source:HGNC Symbol%3BAcc:HGNC:29452]
ENSG00000085511	12.95	13.82	11.98	12.91	13.86	13.68	-0.0528171163677587	6.0511301990997	0.475857350671772	0.808518803762442	6:160991726-161117385:+	MAP3K4	28;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001890,biological_process placenta development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0010225,biological_process response to UV-C;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019100,biological_process male germ-line sex determination;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060718,biological_process chorionic trophoblast cell differentiation;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1904355,biological_process positive regulation of telomere capping	MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]; K04428	mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:6856]
ENSG00000172586	57.80	61.33	47.42	54.76	52.83	51.60	0.0713783156263309	4.45457773218155	0.475875161547442	0.808518803762442	10:73782046-73783652:+	CHCHD1	14;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	coiled-coil-helix-coiled-coil-helix domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23518]
ENSG00000143079	15.77	16.45	15.59	15.54	17.49	17.06	-0.0581349221685301	4.97441170825861	0.476123458489512	0.808728201700144	1:112396180-112463456:+	CTTNBP2NL	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006470,biological_process protein dephosphorylation;GO:0015629,cellular_component actin cytoskeleton;GO:0032410,biological_process negative regulation of transporter activity;GO:0034763,biological_process negative regulation of transmembrane transport;GO:0051721,molecular_function protein phosphatase 2A binding	NA	CTTNBP2 N-terminal like [Source:HGNC Symbol%3BAcc:HGNC:25330]
ENSG00000103363	164.62	164.17	146.94	165.58	166.91	163.40	-0.0491343806020762	6.48766809131644	0.4761355581387	0.808728201700144	16:2771413-2777297:-	ELOB	20;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006414,biological_process translational elongation;GO:0006461,biological_process protein complex assembly;GO:0016567,biological_process protein ubiquitination;GO:0030891,cellular_component VCB complex;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0031466,cellular_component Cul5-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043687,biological_process post-translational protein modification;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0070449,cellular_component elongin complex	ELOB, TCEB2; elongin-B; K03873	elongin B [Source:HGNC Symbol%3BAcc:HGNC:11619]
ENSG00000185650	328.61	287.43	347.15	322.06	291.03	322.15	0.0547080909827588	8.81941355630874	0.476193863387284	0.808728201700144	14:68787659-68796253:-	ZFP36L1	69;GO:0000165,biological_process MAPK cascade;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001570,biological_process vasculogenesis;GO:0003342,biological_process proepicardium development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006402,biological_process mRNA catabolic process;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0008283,biological_process cell proliferation;GO:0009611,biological_process response to wounding;GO:0010468,biological_process regulation of gene expression;GO:0010837,biological_process regulation of keratinocyte proliferation;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0017091,molecular_function AU-rich element binding;GO:0021915,biological_process neural tube development;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031086,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:0031440,biological_process regulation of mRNA 3'-end processing;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033077,biological_process T cell differentiation in thymus;GO:0035264,biological_process multicellular organism growth;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0038066,biological_process p38MAPK cascade;GO:0043488,biological_process regulation of mRNA stability;GO:0043491,biological_process protein kinase B signaling;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045577,biological_process regulation of B cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0045647,biological_process negative regulation of erythrocyte differentiation;GO:0045657,biological_process positive regulation of monocyte differentiation;GO:0045661,biological_process regulation of myoblast differentiation;GO:0046872,molecular_function metal ion binding;GO:0048382,biological_process mesendoderm development;GO:0048568,biological_process embryonic organ development;GO:0051028,biological_process mRNA transport;GO:0060710,biological_process chorio-allantoic fusion;GO:0060712,biological_process spongiotrophoblast layer development;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0071320,biological_process cellular response to cAMP;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0071472,biological_process cellular response to salt stress;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071889,molecular_function 14-3-3 protein binding;GO:0072091,biological_process regulation of stem cell proliferation;GO:0097403,biological_process cellular response to raffinose;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1901991,biological_process negative regulation of mitotic cell cycle phase transition;GO:1902172,biological_process regulation of keratinocyte apoptotic process;GO:1904582,biological_process positive regulation of intracellular mRNA localization;GO:1904628,biological_process cellular response to phorbol 13-acetate 12-myristate	NA	ZFP36 ring finger protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:1107]
ENSG00000179046	3.57	3.10	2.28	2.48	2.35	3.25	0.153721758154759	2.03234608031242	0.476346641630104	0.808876998981461	4:188091272-188109603:-	TRIML2	5;GO:0005515,molecular_function protein binding;GO:0010033,biological_process response to organic substance;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032526,biological_process response to retinoic acid	NA	tripartite motif family like 2 [Source:HGNC Symbol%3BAcc:HGNC:26378]
ENSG00000091262	2.08	2.25	2.28	1.86	2.05	2.33	0.0889575947987292	3.32878968767183	0.47645264363588	0.808946336404347	16:16148927-16223522:-	ABCC6	21;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007601,biological_process visual perception;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016887,molecular_function ATPase activity;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043225,molecular_function anion transmembrane-transporting ATPase activity;GO:0050896,biological_process response to stimulus;GO:0055085,biological_process transmembrane transport;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport	ABCC6; ATP-binding cassette, subfamily C (CFTR/MRP), member 6; K05669	ATP binding cassette subfamily C member 6 [Source:HGNC Symbol%3BAcc:HGNC:57]
ENSG00000243477	9.40	7.96	9.64	9.16	7.88	8.45	0.105688323562129	3.0469909132297	0.476688533203492	0.809236154630054	3:50296401-50299421:-	NAT6	4;GO:0005737,cellular_component cytoplasm;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups	NA	N-acetyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:30252]
ENSG00000106524	43.86	40.49	45.86	45.63	43.65	46.67	-0.0478739511689915	6.0376724018832	0.476966468682567	0.809597261829169	7:16599775-16645817:-	ANKMY2	6;GO:0005515,molecular_function protein binding;GO:0005929,cellular_component cilium;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0019899,molecular_function enzyme binding;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding	NA	ankyrin repeat and MYND domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25370]
ENSG00000083123	15.52	19.32	15.74	17.20	17.87	18.33	-0.0773313547859172	4.38159566415068	0.477322366140347	0.810090583934937	6:80106646-80346270:+	BCKDHB	13;GO:0003824,molecular_function catalytic activity;GO:0003826,molecular_function alpha-ketoacid dehydrogenase activity;GO:0003863,molecular_function 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005947,cellular_component mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0055114,biological_process oxidation-reduction process	BCKDHB, bkdA2; 2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]; K00167	branched chain keto acid dehydrogenase E1 subunit beta [Source:HGNC Symbol%3BAcc:HGNC:987]
ENSG00000159842	26.71	23.02	26.37	26.29	26.35	26.87	-0.0485774486213019	6.40455982021914	0.477478668792606	0.810245073919702	17:1003517-1229021:-	ABR	26;GO:0002692,biological_process negative regulation of cellular extravasation;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007420,biological_process brain development;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030336,biological_process negative regulation of cell migration;GO:0032496,biological_process response to lipopolysaccharide;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042472,biological_process inner ear morphogenesis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043114,biological_process regulation of vascular permeability;GO:0043314,biological_process negative regulation of neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0060313,biological_process negative regulation of blood vessel remodeling	NA	active BCR-related [Source:HGNC Symbol%3BAcc:HGNC:81]
ENSG00000164934	52.53	51.28	49.79	53.56	55.37	51.07	-0.0468064538839199	6.58285094898143	0.477671513056707	0.81028696032599	8:103414713-103443453:+	DCAF13	16;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0016567,biological_process protein ubiquitination;GO:0030054,cellular_component cell junction;GO:0030331,molecular_function estrogen receptor binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 13 [Source:HGNC Symbol%3BAcc:HGNC:24535]
ENSG00000170836	8.83	9.41	8.15	7.26	9.40	8.45	0.0790132250394905	4.02914179406244	0.477772368876678	0.81028696032599	17:60600182-60666280:+	PPM1D	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009267,biological_process cellular response to starvation;GO:0009314,biological_process response to radiation;GO:0009617,biological_process response to bacterium;GO:0016787,molecular_function hydrolase activity;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding;GO:0051019,molecular_function mitogen-activated protein kinase binding	PPM1D, WIP1; protein phosphatase 1D [EC:3.1.3.16]; K10147	protein phosphatase%2C Mg2+/Mn2+ dependent 1D [Source:HGNC Symbol%3BAcc:HGNC:9277]
ENSG00000102362	3.37	3.35	3.01	4.01	2.84	3.76	-0.118358003243728	2.83372053744884	0.477847265954305	0.81028696032599	X:100674490-100732123:-	SYTL4	32;GO:0002576,biological_process platelet degranulation;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019898,cellular_component extrinsic component of membrane;GO:0019905,molecular_function syntaxin binding;GO:0030141,cellular_component secretory granule;GO:0030276,molecular_function clathrin binding;GO:0030658,cellular_component transport vesicle membrane;GO:0031092,cellular_component platelet alpha granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042043,molecular_function neurexin family protein binding;GO:0045921,biological_process positive regulation of exocytosis;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046872,molecular_function metal ion binding;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0050714,biological_process positive regulation of protein secretion;GO:0070382,cellular_component exocytic vesicle;GO:0071985,biological_process multivesicular body sorting pathway;GO:0098793,cellular_component presynapse	NA	synaptotagmin like 4 [Source:HGNC Symbol%3BAcc:HGNC:15588]
ENSG00000173545	28.48	30.52	26.23	28.93	30.26	29.88	-0.0563370899940293	5.38221815390993	0.477856512887337	0.81028696032599	5:16451518-16465792:-	ZNF622	18;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0033674,biological_process positive regulation of kinase activity;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 622 [Source:HGNC Symbol%3BAcc:HGNC:30958]
ENSG00000108932	0.72	0.61	0.89	0.72	0.53	0.63	0.269965614264372	0.296918816168913	0.477869035735285	0.81028696032599	17:68267025-68291267:-	SLC16A6	9;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 16 member 6 [Source:HGNC Symbol%3BAcc:HGNC:10927]
ENSG00000142409	10.36	10.18	9.83	9.69	9.55	9.88	0.0718395846709065	3.85622206071435	0.477958354149668	0.81028696032599	19:56087365-56121280:-	ZNF787	1;GO:0003676,molecular_function nucleic acid binding	NA	zinc finger protein 787 [Source:HGNC Symbol%3BAcc:HGNC:26998]
ENSG00000105221	51.74	51.54	54.96	52.52	52.39	49.53	0.0476651916623285	6.52992197946733	0.477998964204133	0.81028696032599	19:40230316-40285536:-	AKT2	60;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0006006,biological_process glucose metabolic process;GO:0006417,biological_process regulation of translation;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008643,biological_process carbohydrate transport;GO:0010748,biological_process negative regulation of plasma membrane long-chain fatty acid transport;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0010918,biological_process positive regulation of mitochondrial membrane potential;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030334,biological_process regulation of cell migration;GO:0030335,biological_process positive regulation of cell migration;GO:0031340,biological_process positive regulation of vesicle fusion;GO:0032000,biological_process positive regulation of fatty acid beta-oxidation;GO:0032287,biological_process peripheral nervous system myelin maintenance;GO:0032587,cellular_component ruffle membrane;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035556,biological_process intracellular signal transduction;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045444,biological_process fat cell differentiation;GO:0045725,biological_process positive regulation of glycogen biosynthetic process;GO:0046326,biological_process positive regulation of glucose import;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0065002,biological_process intracellular protein transmembrane transport;GO:0071156,biological_process regulation of cell cycle arrest;GO:0071486,biological_process cellular response to high light intensity;GO:0072659,biological_process protein localization to plasma membrane;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0090630,biological_process activation of GTPase activity;GO:0097473,biological_process retinal rod cell apoptotic process;GO:2000147,biological_process positive regulation of cell motility;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]; K04456	AKT serine/threonine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:392]
ENSG00000164463	6.86	6.04	6.32	6.35	5.11	6.76	0.0914872577665826	3.62346890180798	0.478025570810217	0.81028696032599	5:173056351-173139284:+	CREBRF	17;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0006986,biological_process response to unfolded protein;GO:0016604,cellular_component nuclear body;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0042711,biological_process maternal behavior;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1900170,biological_process negative regulation of glucocorticoid mediated signaling pathway;GO:1902213,biological_process positive regulation of prolactin signaling pathway	NA	CREB3 regulatory factor [Source:HGNC Symbol%3BAcc:HGNC:24050]
ENSG00000151917	9.36	9.44	8.23	9.92	10.05	9.09	-0.0947272684878912	3.13028514333897	0.478208026271335	0.810335361949774	6:56955125-57027342:+	BEND6	9;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway	NA	BEN domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:20871]
ENSG00000168273	36.36	41.06	41.16	33.28	35.39	42.97	0.0919308758362648	3.39297802761172	0.478225913423357	0.810335361949774	3:52534012-52579237:+	SMIM4	3;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 4 [Source:HGNC Symbol%3BAcc:HGNC:37257]
ENSG00000234444	6.34	8.58	5.98	7.48	6.81	8.34	-0.121187661097951	3.23283440798535	0.478264239259778	0.810335361949774	7:64307458-64354860:+	ZNF736	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 736 [Source:HGNC Symbol%3BAcc:HGNC:32467]
ENSG00000105053	24.01	26.51	23.84	22.36	25.00	24.63	0.0536360114910949	5.24521206591028	0.478315249899782	0.810335361949774	19:49976466-50025946:-	VRK3	17;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0008360,biological_process regulation of cell shape;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019903,molecular_function protein phosphatase binding;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	NA	vaccinia related kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:18996]
ENSG00000133317	2.45	1.70	2.77	1.78	2.63	1.74	0.209303779035681	1.24349916653937	0.478484571646407	0.810356431547085	11:63506083-63516774:+	LGALS12	8;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0030246,molecular_function carbohydrate binding;GO:0030395,molecular_function lactose binding;GO:0045598,biological_process regulation of fat cell differentiation;GO:0050994,biological_process regulation of lipid catabolic process;GO:0097193,biological_process intrinsic apoptotic signaling pathway	NA	galectin 12 [Source:HGNC Symbol%3BAcc:HGNC:15788]
ENSG00000205085	1.37	1.44	2.14	1.70	2.05	2.12	-0.221587288286074	0.87659560706195	0.478518997919299	0.810356431547085	7:128672287-128687872:+	FAM71F2	1;GO:0005634,cellular_component nucleus	NA	family with sequence similarity 71 member F2 [Source:HGNC Symbol%3BAcc:HGNC:27998]
ENSG00000149636	19.11	20.22	20.05	19.42	22.23	20.94	-0.0658784378080183	4.45083163274653	0.478523535264652	0.810356431547085	20:36751790-36773818:-	DSN1	20;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000444,cellular_component MIS12/MIND type complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000818,cellular_component nuclear MIS12/MIND complex;GO:0000922,cellular_component spindle pole;GO:0000941,cellular_component condensed nuclear chromosome inner kinetochore;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0051301,biological_process cell division;GO:0051456,biological_process attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation	NA	DSN1 homolog%2C MIS12 kinetochore complex component [Source:HGNC Symbol%3BAcc:HGNC:16165]
ENSG00000197444	2.77	3.50	3.16	2.69	4.98	2.85	-0.149491794929495	3.34927654731327	0.478718736597397	0.810472572706956	10:49734642-49762379:-	OGDHL	13;GO:0004591,molecular_function oxoglutarate dehydrogenase (succinyl-transferring) activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006096,biological_process glycolytic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016624,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;GO:0030976,molecular_function thiamine pyrophosphate binding;GO:0045252,cellular_component oxoglutarate dehydrogenase complex;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	OGDH, sucA; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]; K00164	oxoglutarate dehydrogenase like [Source:HGNC Symbol%3BAcc:HGNC:25590]
ENSG00000164941	23.90	23.95	24.20	24.34	23.24	22.81	0.0453328000049873	6.36010112910354	0.478722702254685	0.810472572706956	8:94813310-94881746:+	INTS8	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016180,biological_process snRNA processing;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:26048]
ENSG00000136936	18.07	20.38	17.50	19.88	18.35	20.84	-0.0755243137712603	4.17921072681145	0.47888020783693	0.810628667650322	9:97674908-97697357:-	XPA	35;GO:0000110,cellular_component nucleotide-excision repair factor 1 complex;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009411,biological_process response to UV;GO:0009636,biological_process response to toxic substance;GO:0009650,biological_process UV protection;GO:0010996,biological_process response to auditory stimulus;GO:0019904,molecular_function protein domain specific binding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034504,biological_process protein localization to nucleus;GO:0035264,biological_process multicellular organism growth;GO:0042803,molecular_function protein homodimerization activity;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070914,biological_process UV-damage excision repair;GO:1901255,biological_process nucleotide-excision repair involved in interstrand cross-link repair	XPA; DNA-repair protein complementing XP-A cells; K10847	XPA%2C DNA damage recognition and repair factor [Source:HGNC Symbol%3BAcc:HGNC:12814]
ENSG00000163961	8.58	7.42	9.50	8.26	6.91	8.99	0.0948935563599552	3.84676924505634	0.479263054878312	0.81109576485999	3:196468782-196503768:-	RNF168	32;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003682,molecular_function chromatin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010212,biological_process response to ionizing radiation;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0031491,molecular_function nucleosome binding;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0035518,biological_process histone H2A monoubiquitination;GO:0035861,cellular_component site of double-strand break;GO:0036297,biological_process interstrand cross-link repair;GO:0036351,biological_process histone H2A-K13 ubiquitination;GO:0036352,biological_process histone H2A-K15 ubiquitination;GO:0042393,molecular_function histone binding;GO:0043130,molecular_function ubiquitin binding;GO:0043234,cellular_component protein complex;GO:0045190,biological_process isotype switching;GO:0045739,biological_process positive regulation of DNA repair;GO:0046872,molecular_function metal ion binding;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070535,biological_process histone H2A K63-linked ubiquitination	NA	ring finger protein 168 [Source:HGNC Symbol%3BAcc:HGNC:26661]
ENSG00000136770	17.89	15.07	16.87	18.97	16.29	17.39	-0.0616276194151461	4.83907266304825	0.479286831164749	0.81109576485999	10:21756536-22003769:-	DNAJC1	18;GO:0001671,molecular_function ATPase activator activity;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006417,biological_process regulation of translation;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031090,cellular_component organelle membrane;GO:0031965,cellular_component nuclear membrane;GO:0032781,biological_process positive regulation of ATPase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045861,biological_process negative regulation of proteolysis;GO:0050708,biological_process regulation of protein secretion;GO:0051087,molecular_function chaperone binding	DNAJC1; DnaJ homolog subfamily C member 1; K09521	DnaJ heat shock protein family (Hsp40) member C1 [Source:HGNC Symbol%3BAcc:HGNC:20090]
ENSG00000140280	8.45	7.23	9.42	7.52	9.18	11.03	-0.124768594477856	2.72264902583732	0.479433076110154	0.811232657273084	15:51723010-51751585:-	LYSMD2	NA	NA	LysM domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28571]
ENSG00000205571	4.79	5.13	5.00	3.57	5.23	4.92	0.12975172985482	2.27895467846716	0.479618579058264	0.811338498219714	5:70049611-70078522:+	SMN2	23;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006397,biological_process mRNA processing;GO:0007399,biological_process nervous system development;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0030018,cellular_component Z disc;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043204,cellular_component perikaryon;GO:0051170,biological_process nuclear import;GO:0097504,cellular_component Gemini of coiled bodies	SMN; survival motor neuron protein; K13129	survival of motor neuron 2%2C centromeric [Source:HGNC Symbol%3BAcc:HGNC:11118]
ENSG00000172687	10.96	10.06	9.14	10.61	9.72	7.88	0.11200832649219	2.87801813745201	0.47970599540924	0.811338498219714	19:21358929-21379302:+	ZNF738	8;GO:0000209,biological_process protein polyubiquitination;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	zinc finger protein 738 [Source:HGNC Symbol%3BAcc:HGNC:32469]
ENSG00000008294	55.23	55.37	56.40	52.48	56.74	54.22	0.0429793738994896	7.86243028107092	0.479752711022906	0.811338498219714	17:50962173-51120865:-	SPAG9	26;GO:0000187,biological_process activation of MAPK activity;GO:0001669,cellular_component acrosomal vesicle;GO:0005078,molecular_function MAP-kinase scaffold activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0007257,biological_process activation of JUN kinase activity;GO:0007283,biological_process spermatogenesis;GO:0008432,molecular_function JUN kinase binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019894,molecular_function kinesin binding;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030335,biological_process positive regulation of cell migration;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0048273,molecular_function mitogen-activated protein kinase p38 binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051146,biological_process striated muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051260,biological_process protein homooligomerization;GO:0070062,cellular_component extracellular exosome;GO:0090074,biological_process negative regulation of protein homodimerization activity	NA	sperm associated antigen 9 [Source:HGNC Symbol%3BAcc:HGNC:14524]
ENSG00000134452	25.46	24.77	25.63	24.95	25.61	23.52	0.0471025262227822	6.38412666948561	0.479904411302449	0.811338498219714	10:5890202-5937594:+	FBXO18	30;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000737,biological_process DNA catabolic process, endonucleolytic;GO:0000785,cellular_component chromatin;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008219,biological_process cell death;GO:0015616,molecular_function DNA translocase activity;GO:0016567,biological_process protein ubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031297,biological_process replication fork processing;GO:0032508,biological_process DNA duplex unwinding;GO:0035562,biological_process negative regulation of chromatin binding;GO:0043138,molecular_function 3'-5' DNA helicase activity;GO:0048478,biological_process replication fork protection;GO:0072429,biological_process response to intra-S DNA damage checkpoint signaling;GO:1902231,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination	NA	F-box protein%2C helicase%2C 18 [Source:HGNC Symbol%3BAcc:HGNC:13620]
ENSG00000153707	13.11	12.81	13.02	12.47	13.12	12.49	0.0449410858284723	6.26869885936795	0.479990044020634	0.811338498219714	9:8314245-10612723:-	PTPRD	23;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007185,biological_process transmembrane receptor protein tyrosine phosphatase signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030182,biological_process neuron differentiation;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051965,biological_process positive regulation of synapse assembly;GO:0070062,cellular_component extracellular exosome;GO:0097105,biological_process presynaptic membrane assembly	NA	protein tyrosine phosphatase%2C receptor type D [Source:HGNC Symbol%3BAcc:HGNC:9668]
ENSG00000169519	12.11	10.30	11.70	9.32	11.43	11.89	0.080787389693062	4.23969314770959	0.480004800490803	0.811338498219714	11:28108247-28527041:+	METTL15	7;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0070475,biological_process rRNA base methylation;GO:0071424,molecular_function rRNA (cytosine-N4-)-methyltransferase activity	NA	methyltransferase like 15 [Source:HGNC Symbol%3BAcc:HGNC:26606]
ENSG00000131171	123.49	134.97	133.00	112.53	136.83	129.33	0.0576786047089885	5.46063511186353	0.480041998037625	0.811338498219714	X:81201942-81298547:+	SH3BGRL	7;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0009967,biological_process positive regulation of signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0070062,cellular_component extracellular exosome	NA	SH3 domain binding glutamate rich protein like [Source:HGNC Symbol%3BAcc:HGNC:10823]
ENSG00000006837	3.27	2.92	2.44	3.19	2.80	3.48	-0.123398270027616	2.56048561071347	0.480080563235876	0.811338498219714	5:134286349-134371047:-	CDKL3	17;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030517,biological_process negative regulation of axon extension;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0051726,biological_process regulation of cell cycle;GO:0097484,biological_process dendrite extension	NA	cyclin dependent kinase like 3 [Source:HGNC Symbol%3BAcc:HGNC:15483]
ENSG00000116991	15.35	13.56	16.20	15.24	12.86	15.55	0.0611058561290735	6.27298375086885	0.480083885396262	0.811338498219714	1:232397964-232561558:-	SIPA1L2	5;GO:0005096,molecular_function GTPase activator activity;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	signal induced proliferation associated 1 like 2 [Source:HGNC Symbol%3BAcc:HGNC:23800]
ENSG00000122884	48.60	44.16	46.79	49.96	47.40	48.05	-0.0453343575120657	6.32014428049232	0.480182504884976	0.811394695499211	10:73007216-73096974:-	P4HA1	19;GO:0004656,molecular_function procollagen-proline 4-dioxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005581,cellular_component collagen trimer;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0016020,cellular_component membrane;GO:0016222,cellular_component procollagen-proline 4-dioxygenase complex;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0018401,biological_process peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0030199,biological_process collagen fibril organization;GO:0031418,molecular_function L-ascorbic acid binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	P4HA; prolyl 4-hydroxylase [EC:1.14.11.2]; K00472	prolyl 4-hydroxylase subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:8546]
ENSG00000184584	25.16	25.47	30.36	25.62	25.75	26.84	0.0643302270063835	4.92402346128323	0.48037539333165	0.81154969508212	5:139475533-139482935:-	TMEM173	41;GO:0000166,molecular_function nucleotide binding;GO:0002218,biological_process activation of innate immune response;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0008134,molecular_function transcription factor binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032479,biological_process regulation of type I interferon production;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032608,biological_process interferon-beta production;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0035438,molecular_function cyclic-di-GMP binding;GO:0035458,biological_process cellular response to interferon-beta;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051607,biological_process defense response to virus;GO:0061507,molecular_function cyclic-GMP-AMP binding;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0071407,biological_process cellular response to organic cyclic compound	TMEM173, MITA; transmembrane protein 173; K12654	transmembrane protein 173 [Source:HGNC Symbol%3BAcc:HGNC:27962]
ENSG00000074276	0.41	0.50	0.31	0.36	0.47	0.21	0.229851497226222	0.709815592087542	0.480463475730733	0.81154969508212	5:176542510-176595974:+	CDHR2	22;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030855,biological_process epithelial cell differentiation;GO:0031526,cellular_component brush border membrane;GO:0031528,cellular_component microvillus membrane;GO:0032532,biological_process regulation of microvillus length;GO:0042995,cellular_component cell projection;GO:0044214,cellular_component spanning component of plasma membrane;GO:0044331,biological_process cell-cell adhesion mediated by cadherin;GO:0050839,molecular_function cell adhesion molecule binding;GO:0060243,biological_process negative regulation of cell growth involved in contact inhibition;GO:0070062,cellular_component extracellular exosome;GO:0090675,biological_process intermicrovillar adhesion	NA	cadherin related family member 2 [Source:HGNC Symbol%3BAcc:HGNC:18231]
ENSG00000175322	2.74	2.57	2.19	2.87	2.51	2.89	-0.132673539203027	2.25136433334314	0.480481240862991	0.81154969508212	18:14057456-14132490:-	ZNF519	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 519 [Source:HGNC Symbol%3BAcc:HGNC:30574]
ENSG00000142632	2.30	2.05	2.09	2.21	1.63	2.13	0.124075608134379	2.47479186923228	0.480535749524981	0.81154969508212	1:16197853-16212609:-	ARHGEF19	12;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042060,biological_process wound healing;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway	NA	Rho guanine nucleotide exchange factor 19 [Source:HGNC Symbol%3BAcc:HGNC:26604]
ENSG00000140859	19.43	20.39	16.07	18.24	20.88	19.66	-0.0634545830780287	6.01206676657608	0.480621753021428	0.811584521868451	16:57758216-57863053:-	KIFC3	28;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005912,cellular_component adherens junction;GO:0005915,cellular_component zonula adherens;GO:0007017,biological_process microtubule-based process;GO:0007018,biological_process microtubule-based movement;GO:0007030,biological_process Golgi organization;GO:0007601,biological_process visual perception;GO:0008017,molecular_function microtubule binding;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045218,biological_process zonula adherens maintenance;GO:0070062,cellular_component extracellular exosome;GO:0090136,biological_process epithelial cell-cell adhesion	NA	kinesin family member C3 [Source:HGNC Symbol%3BAcc:HGNC:6326]
ENSG00000074266	18.07	20.77	20.47	18.25	20.00	18.95	0.0597271191097164	4.7701049533174	0.480703429887302	0.81161203416636	11:86244543-86278813:+	EED	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001739,cellular_component sex chromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0021510,biological_process spinal cord development;GO:0035098,cellular_component ESC/E(Z) complex;GO:0042054,molecular_function histone methyltransferase activity;GO:0042802,molecular_function identical protein binding;GO:0045120,cellular_component pronucleus;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046976,molecular_function histone methyltransferase activity (H3-K27 specific);GO:0061087,biological_process positive regulation of histone H3-K27 methylation;GO:0070734,biological_process histone H3-K27 methylation;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000011,biological_process regulation of adaxial/abaxial pattern formation	NA	embryonic ectoderm development [Source:HGNC Symbol%3BAcc:HGNC:3188]
ENSG00000181449	1.04	1.21	0.46	0.79	1.04	1.55	-0.341080863903701	0.156643258803387	0.480942617771789	0.81190544191503	3:181711923-181714436:+	SOX2	43;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001649,biological_process osteoblast differentiation;GO:0001654,biological_process eye development;GO:0001714,biological_process endodermal cell fate specification;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007050,biological_process cell cycle arrest;GO:0007275,biological_process multicellular organism development;GO:0009611,biological_process response to wounding;GO:0010468,biological_process regulation of gene expression;GO:0021781,biological_process glial cell fate commitment;GO:0021983,biological_process pituitary gland development;GO:0021984,biological_process adenohypophysis development;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030900,biological_process forebrain development;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035198,molecular_function miRNA binding;GO:0042246,biological_process tissue regeneration;GO:0043281,biological_process regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048839,biological_process inner ear development;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0070848,biological_process response to growth factor;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097150,biological_process neuronal stem cell population maintenance	SOX2; transcription factor SOX2 (SOX group B); K16796	SRY-box 2 [Source:HGNC Symbol%3BAcc:HGNC:11195]
ENSG00000169599	33.68	37.78	35.55	32.61	34.42	36.36	0.0559708035053998	4.85550958790944	0.481238767743411	0.812294917595724	2:69395749-69437628:-	NFU1	11;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding	NA	NFU1 iron-sulfur cluster scaffold [Source:HGNC Symbol%3BAcc:HGNC:16287]
ENSG00000184992	3.38	2.79	3.91	3.08	4.73	3.74	-0.167602676572462	1.52924308695444	0.481305993355269	0.812297932769403	12:124993699-125031231:+	BRI3BP	4;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	BRI3 binding protein [Source:HGNC Symbol%3BAcc:HGNC:14251]
ENSG00000161203	346.35	367.72	346.53	345.89	356.61	335.46	0.0426527240584803	9.13323261526454	0.481374403106058	0.812302945317496	3:184174688-184184091:+	AP2M1	37;GO:0005048,molecular_function signal sequence binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007018,biological_process microtubule-based movement;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016185,biological_process synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035615,molecular_function clathrin adaptor activity;GO:0036020,cellular_component endolysosome membrane;GO:0043195,cellular_component terminal bouton;GO:0044325,molecular_function ion channel binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0097718,molecular_function disordered domain specific binding;GO:1903077,biological_process negative regulation of protein localization to plasma membrane	AP2M1; AP-2 complex subunit mu-1; K11826	adaptor related protein complex 2 mu 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:564]
ENSG00000132881	4.47	4.82	3.71	5.22	4.51	4.72	-0.152121045511218	1.88248031180837	0.481502715093766	0.812409025752198	1:16231699-16237162:-	RSG1	18;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0015031,biological_process protein transport;GO:0017157,biological_process regulation of exocytosis;GO:0030030,biological_process cell projection organization;GO:0031338,biological_process regulation of vesicle fusion;GO:0034613,biological_process cellular protein localization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	REM2 and RAB like small GTPase 1 [Source:HGNC Symbol%3BAcc:HGNC:28127]
ENSG00000183150	2.61	2.46	2.78	3.01	2.44	3.33	-0.148049807363572	1.85610828432815	0.481713906126247	0.812517197778754	12:12660890-12696207:-	GPR19	11;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0007631,biological_process feeding behavior;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 19 [Source:HGNC Symbol%3BAcc:HGNC:4473]
ENSG00000121579	82.49	86.05	84.81	84.23	90.95	89.00	-0.0501958919913685	5.47033963625886	0.481765428256886	0.812517197778754	3:113716459-113746300:-	NAA50	14;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006474,biological_process N-terminal protein amino acid acetylation;GO:0008080,molecular_function N-acetyltransferase activity;GO:0010485,molecular_function H4 histone acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0031415,cellular_component NatA complex;GO:0043967,biological_process histone H4 acetylation;GO:0052858,molecular_function peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0070062,cellular_component extracellular exosome;GO:0071962,biological_process mitotic sister chromatid cohesion, centromeric	NA	N(alpha)-acetyltransferase 50%2C NatE catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:29533]
ENSG00000103494	4.67	5.56	4.50	4.95	4.69	4.42	0.0711880831006053	4.32383019790952	0.481779011182148	0.812517197778754	16:53597682-53703938:-	RPGRIP1L	46;GO:0001701,biological_process in utero embryonic development;GO:0001736,biological_process establishment of planar polarity;GO:0001822,biological_process kidney development;GO:0001889,biological_process liver development;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005879,cellular_component axonemal microtubule;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007368,biological_process determination of left/right symmetry;GO:0007420,biological_process brain development;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0021532,biological_process neural tube patterning;GO:0021537,biological_process telencephalon development;GO:0021549,biological_process cerebellum development;GO:0021670,biological_process lateral ventricle development;GO:0021772,biological_process olfactory bulb development;GO:0022038,biological_process corpus callosum development;GO:0030054,cellular_component cell junction;GO:0031870,molecular_function thromboxane A2 receptor binding;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035108,biological_process limb morphogenesis;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0043584,biological_process nose development;GO:0044767,biological_process single-organism developmental process;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0060039,biological_process pericardium development;GO:0060271,biological_process cilium morphogenesis;GO:0060322,biological_process head development;GO:0090102,biological_process cochlea development;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1905515,biological_process non-motile cilium assembly	NA	RPGRIP1 like [Source:HGNC Symbol%3BAcc:HGNC:29168]
ENSG00000173207	317.01	340.32	311.26	354.36	337.53	318.04	-0.0502132355270364	6.43557078442309	0.481828654865819	0.812517197778754	1:154974652-154979249:+	CKS1B	17;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019901,molecular_function protein kinase binding;GO:0042393,molecular_function histone binding;GO:0043130,molecular_function ubiquitin binding;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045859,biological_process regulation of protein kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051301,biological_process cell division;GO:0061575,molecular_function cyclin-dependent protein serine/threonine kinase activator activity	NA	CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol%3BAcc:HGNC:19083]
ENSG00000187775	0.39	0.41	0.42	0.35	0.37	0.64	-0.159473729570768	2.58409433686197	0.48195875464436	0.812577923133696	17:78423696-78577394:-	DNAH17	21;GO:0000166,molecular_function nucleotide binding;GO:0003341,biological_process cilium movement;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005858,cellular_component axonemal dynein complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007018,biological_process microtubule-based movement;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0016887,molecular_function ATPase activity;GO:0030286,cellular_component dynein complex;GO:0031514,cellular_component motile cilium;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060285,biological_process cilium-dependent cell motility	NA	dynein axonemal heavy chain 17 [Source:HGNC Symbol%3BAcc:HGNC:2946]
ENSG00000118507	5.03	5.41	5.77	4.68	5.01	5.52	0.100858414778371	2.87987652193787	0.481995589143108	0.812577923133696	6:131135665-131283535:+	AKAP7	25;GO:0000166,molecular_function nucleotide binding;GO:0001508,biological_process action potential;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006811,biological_process ion transport;GO:0008104,biological_process protein localization;GO:0008150,biological_process biological_process;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0019901,molecular_function protein kinase binding;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0035556,biological_process intracellular signal transduction;GO:0051018,molecular_function protein kinase A binding;GO:0060306,biological_process regulation of membrane repolarization;GO:0071320,biological_process cellular response to cAMP;GO:1901381,biological_process positive regulation of potassium ion transmembrane transport;GO:1902261,biological_process positive regulation of delayed rectifier potassium channel activity	NA	A-kinase anchoring protein 7 [Source:HGNC Symbol%3BAcc:HGNC:377]
ENSG00000141337	3.23	2.55	2.29	3.04	2.07	2.19	0.162554917235819	2.06774762010312	0.48225987980673	0.81279409273016	17:68259181-68422731:+	ARSG	13;GO:0003824,molecular_function catalytic activity;GO:0004065,molecular_function arylsulfatase activity;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006790,biological_process sulfur compound metabolic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	ARSG; arylsulfatase G [EC:3.1.6.-]; K12381	arylsulfatase G [Source:HGNC Symbol%3BAcc:HGNC:24102]
ENSG00000157014	3.34	2.30	2.64	3.21	2.86	3.02	-0.105697051658908	2.76886517969008	0.482297771870943	0.81279409273016	3:10248022-10281218:+	TATDN2	12;GO:0004518,molecular_function nuclease activity;GO:0004536,molecular_function deoxyribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006259,biological_process DNA metabolic process;GO:0006308,biological_process DNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0016888,molecular_function endodeoxyribonuclease activity, producing 5'-phosphomonoesters;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	TatD DNase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28988]
ENSG00000166963	0.43	0.53	0.52	0.32	0.60	0.42	0.159716665105706	2.14991905933358	0.482320251917374	0.81279409273016	15:43510957-43531620:+	MAP1A	8;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0008017,molecular_function microtubule binding	NA	microtubule associated protein 1A [Source:HGNC Symbol%3BAcc:HGNC:6835]
ENSG00000108010	85.59	84.06	85.39	93.57	87.31	84.73	-0.0462399358144478	6.45008709040263	0.482622724575468	0.813193413893754	10:130136398-130184521:+	GLRX3	20;GO:0002026,biological_process regulation of the force of heart contraction;GO:0003723,molecular_function RNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005938,cellular_component cell cortex;GO:0009055,molecular_function electron carrier activity;GO:0010614,biological_process negative regulation of cardiac muscle hypertrophy;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0030018,cellular_component Z disc;GO:0030425,cellular_component dendrite;GO:0044571,biological_process [2Fe-2S] cluster assembly;GO:0045454,biological_process cell redox homeostasis;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0097428,biological_process protein maturation by iron-sulfur cluster transfer	NA	glutaredoxin 3 [Source:HGNC Symbol%3BAcc:HGNC:15987]
ENSG00000108509	13.11	10.98	13.38	13.10	9.88	12.93	0.0758036378677938	5.5579941869752	0.482725419409661	0.813233431464387	17:4967991-4987652:-	CAMTA2	14;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0042826,molecular_function histone deacetylase binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	calmodulin binding transcription activator 2 [Source:HGNC Symbol%3BAcc:HGNC:18807]
ENSG00000133275	35.54	33.66	37.04	37.05	36.85	36.83	-0.0453093936970598	5.8201200394395	0.482811924972855	0.813233431464387	19:1941148-1981338:+	CSNK1G2	23;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0042277,molecular_function peptide binding;GO:0046777,biological_process protein autophosphorylation;GO:0051219,molecular_function phosphoprotein binding	CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]; K08958	casein kinase 1 gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:2455]
ENSG00000142046	12.02	11.43	11.43	11.36	11.41	10.40	0.0879388018622383	3.22510024606907	0.482843018600864	0.813233431464387	19:41350910-41384083:+	TMEM91	7;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0009607,biological_process response to biotic stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 91 [Source:HGNC Symbol%3BAcc:HGNC:32393]
ENSG00000166260	81.95	82.81	79.70	82.85	82.70	88.64	-0.0456499635416933	6.27443205358324	0.483028476936094	0.813255327653984	17:54951901-54968785:-	COX11	11;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005507,molecular_function copper ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0007585,biological_process respiratory gaseous exchange;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033132,biological_process negative regulation of glucokinase activity;GO:1902600,biological_process hydrogen ion transmembrane transport	COX11, ctaG; cytochrome c oxidase assembly protein subunit 11; K02258	COX11%2C cytochrome c oxidase copper chaperone [Source:HGNC Symbol%3BAcc:HGNC:2261]
ENSG00000167524	4.81	3.59	4.96	5.10	4.30	5.33	-0.114327703476721	2.66028437045077	0.483034596573008	0.813255327653984	17:28607963-28614200:-	SGK494	3;GO:0004672,molecular_function protein kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation	NA	uncharacterized serine/threonine-protein kinase SgK494 [Source:NCBI gene%3BAcc:124923]
ENSG00000196387	6.23	5.52	6.36	5.72	5.37	6.12	0.0915212703023738	3.27150293922444	0.483065952781833	0.813255327653984	12:133079837-133107544:+	ZNF140	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 140 [Source:HGNC Symbol%3BAcc:HGNC:12925]
ENSG00000007923	29.50	32.27	30.15	31.88	34.03	30.01	-0.0517555014346241	6.03997994833571	0.483118084759565	0.813255327653984	1:6634167-6701924:-	DNAJC11	4;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0070062,cellular_component extracellular exosome	NA	DnaJ heat shock protein family (Hsp40) member C11 [Source:HGNC Symbol%3BAcc:HGNC:25570]
ENSG00000198939	0.61	0.76	0.64	0.32	0.16	1.07	0.343449901067191	-0.0361715920979909	0.483365835996319	0.81342726640119	5:178895893-178933212:+	ZFP2	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	ZFP2 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:26138]
ENSG00000140319	300.78	342.35	314.32	304.77	324.49	303.75	0.0477832643878542	7.32969052211005	0.483421703683372	0.81342726640119	15:40035738-40039188:-	SRP14	19;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005786,cellular_component signal recognition particle, endoplasmic reticulum targeting;GO:0005829,cellular_component cytosol;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008312,molecular_function 7S RNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030942,molecular_function endoplasmic reticulum signal peptide binding;GO:0034774,cellular_component secretory granule lumen;GO:0042493,biological_process response to drug;GO:0043312,biological_process neutrophil degranulation;GO:0045047,biological_process protein targeting to ER;GO:0048500,cellular_component signal recognition particle;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	SRP14; signal recognition particle subunit SRP14; K03104	signal recognition particle 14 [Source:HGNC Symbol%3BAcc:HGNC:11299]
ENSG00000116128	11.64	12.35	11.73	10.54	12.60	11.52	0.0536578388329818	5.65324810059092	0.483464707222355	0.81342726640119	1:147541411-147626216:+	BCL9	15;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0008013,molecular_function beta-catenin binding;GO:0014908,biological_process myotube differentiation involved in skeletal muscle regeneration;GO:0016055,biological_process Wnt signaling pathway;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060070,biological_process canonical Wnt signaling pathway;GO:1904837,biological_process beta-catenin-TCF complex assembly	NA	B-cell CLL/lymphoma 9 [Source:HGNC Symbol%3BAcc:HGNC:1008]
ENSG00000090060	78.92	76.53	77.15	77.32	74.44	76.12	0.0415445855689143	7.67341588078206	0.483652338583057	0.81342726640119	14:96501432-96567111:+	PAPOLA	21;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0004652,molecular_function polynucleotide adenylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0030145,molecular_function manganese ion binding;GO:0031123,biological_process RNA 3'-end processing;GO:0031124,biological_process mRNA 3'-end processing;GO:0031440,biological_process regulation of mRNA 3'-end processing;GO:0043631,biological_process RNA polyadenylation;GO:0046872,molecular_function metal ion binding	PAP; poly(A) polymerase [EC:2.7.7.19]; K14376	poly(A) polymerase alpha [Source:HGNC Symbol%3BAcc:HGNC:14981]
ENSG00000163832	20.99	20.48	21.18	23.59	21.83	20.68	-0.0629564728798344	4.3649232905366	0.483661685601091	0.81342726640119	3:47495639-47513761:-	ELP6	8;GO:0003674,molecular_function molecular_function;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0033588,cellular_component Elongator holoenzyme complex	NA	elongator acetyltransferase complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:25976]
ENSG00000187764	16.78	18.73	18.13	18.38	18.28	19.21	-0.0501392703094769	5.86010951528003	0.483712040847143	0.81342726640119	9:89360786-89498130:-	SEMA4D	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008360,biological_process regulation of cell shape;GO:0010693,biological_process negative regulation of alkaline phosphatase activity;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030215,molecular_function semaphorin receptor binding;GO:0030335,biological_process positive regulation of cell migration;GO:0031344,biological_process regulation of cell projection organization;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043931,biological_process ossification involved in bone maturation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0048672,biological_process positive regulation of collateral sprouting;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050732,biological_process negative regulation of peptidyl-tyrosine phosphorylation;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050919,biological_process negative chemotaxis;GO:0070486,biological_process leukocyte aggregation;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:1900220,biological_process semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis	SEMA4, CD100; semaphorin 4; K06521	semaphorin 4D [Source:HGNC Symbol%3BAcc:HGNC:10732]
ENSG00000115760	10.76	11.60	11.31	11.06	11.06	10.80	0.0433829163430157	7.33915636538198	0.483727835410871	0.81342726640119	2:32357027-32618899:+	BIRC6	31;GO:0000922,cellular_component spindle pole;GO:0001890,biological_process placenta development;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030496,cellular_component midbody;GO:0032465,biological_process regulation of cytokinesis;GO:0042127,biological_process regulation of cell proliferation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051301,biological_process cell division;GO:0060711,biological_process labyrinthine layer development;GO:0060712,biological_process spongiotrophoblast layer development;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]; K10586	baculoviral IAP repeat containing 6 [Source:HGNC Symbol%3BAcc:HGNC:13516]
ENSG00000187808	1.35	2.83	1.79	1.19	2.09	1.79	0.209650064729833	0.888991148417027	0.4838855416308	0.81342726640119	X:119758612-119760164:+	SOWAHD	NA	NA	sosondowah ankyrin repeat domain family member D [Source:HGNC Symbol%3BAcc:HGNC:32960]
ENSG00000177432	3.36	5.25	4.99	3.15	4.58	4.25	0.174442409410829	1.29831858978382	0.483901670309428	0.81342726640119	4:88695914-88698235:-	NAP1L5	2;GO:0005634,cellular_component nucleus;GO:0006334,biological_process nucleosome assembly	NA	nucleosome assembly protein 1 like 5 [Source:HGNC Symbol%3BAcc:HGNC:19968]
ENSG00000170889	760.29	707.24	676.49	767.78	721.65	740.56	-0.0449467145108401	8.9204325550293	0.483903300649102	0.81342726640119	19:54200741-54249003:+	RPS9	26;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045182,molecular_function translation regulator activity;GO:0045903,biological_process positive regulation of translational fidelity;GO:0070062,cellular_component extracellular exosome	RP-S9e, RPS9; small subunit ribosomal protein S9e; K02997	ribosomal protein S9 [Source:HGNC Symbol%3BAcc:HGNC:10442]
ENSG00000021574	5.96	5.74	5.42	6.77	6.28	5.33	-0.0878988785114326	3.47075054251704	0.483961823032231	0.81342726640119	2:32063610-32157637:+	SPAST	57;GO:0000166,molecular_function nucleotide binding;GO:0000281,biological_process mitotic cytokinesis;GO:0000815,cellular_component ESCRT III complex;GO:0001578,biological_process microtubule bundle formation;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006998,biological_process nuclear envelope organization;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0008017,molecular_function microtubule binding;GO:0008089,biological_process anterograde axonal transport;GO:0008152,biological_process metabolic process;GO:0008568,molecular_function microtubule-severing ATPase activity;GO:0010458,biological_process exit from mitosis;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019896,biological_process axonal transport of mitochondrion;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0031117,biological_process positive regulation of microtubule depolymerization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031468,biological_process nuclear envelope reassembly;GO:0031965,cellular_component nuclear membrane;GO:0032467,biological_process positive regulation of cytokinesis;GO:0032506,biological_process cytokinetic process;GO:0034214,biological_process protein hexamerization;GO:0043014,molecular_function alpha-tubulin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048487,molecular_function beta-tubulin binding;GO:0051013,biological_process microtubule severing;GO:0051228,biological_process mitotic spindle disassembly;GO:0051230,biological_process spindle disassembly;GO:0051260,biological_process protein homooligomerization;GO:0051301,biological_process cell division;GO:0061640,biological_process cytoskeleton-dependent cytokinesis;GO:0070062,cellular_component extracellular exosome;GO:0090148,biological_process membrane fission;GO:1904115,cellular_component axon cytoplasm	NA	spastin [Source:HGNC Symbol%3BAcc:HGNC:11233]
ENSG00000265972	563.94	409.23	594.31	592.61	470.01	615.48	-0.0864278799998156	9.411879248813	0.48400658903079	0.81342726640119	1:145992434-145996600:-	TXNIP	27;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006606,biological_process protein import into nucleus;GO:0006979,biological_process response to oxidative stress;GO:0007049,biological_process cell cycle;GO:0009612,biological_process response to mechanical stimulus;GO:0009749,biological_process response to glucose;GO:0030216,biological_process keratinocyte differentiation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032355,biological_process response to estradiol;GO:0032570,biological_process response to progesterone;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0051592,biological_process response to calcium ion;GO:0051782,biological_process negative regulation of cell division;GO:0071228,biological_process cellular response to tumor cell	NA	thioredoxin interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16952]
ENSG00000216490	48.31	53.52	51.62	50.51	51.07	47.35	0.0520044531013184	5.24488627832809	0.484512086039374	0.814139304906972	19:18173161-18178117:+	IFI30	14;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0016667,molecular_function oxidoreductase activity, acting on a sulfur group of donors;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030054,cellular_component cell junction;GO:0042590,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055114,biological_process oxidation-reduction process;GO:0060333,biological_process interferon-gamma-mediated signaling pathway	IFI30, GILT; interferon, gamma-inducible protein 30; K08059	IFI30%2C lysosomal thiol reductase [Source:HGNC Symbol%3BAcc:HGNC:5398]
ENSG00000167701	3.18	2.89	5.39	3.37	3.87	3.12	0.168660106306362	2.48412606955656	0.4845614424114	0.814139304906972	8:144502972-144507174:+	GPT	12;GO:0003824,molecular_function catalytic activity;GO:0004021,molecular_function L-alanine:2-oxoglutarate aminotransferase activity;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042853,biological_process L-alanine catabolic process;GO:0070062,cellular_component extracellular exosome	GPT, ALT; alanine transaminase [EC:2.6.1.2]; K00814	glutamic--pyruvic transaminase [Source:HGNC Symbol%3BAcc:HGNC:4552]
ENSG00000116199	14.62	15.58	12.42	15.56	14.28	15.24	-0.076552627466466	4.17531348022443	0.484689680659801	0.814244553529587	1:179025803-179076562:+	FAM20B	15;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0046872,molecular_function metal ion binding;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	FAM20B%2C glycosaminoglycan xylosylkinase [Source:HGNC Symbol%3BAcc:HGNC:23017]
ENSG00000131023	9.62	9.60	9.51	9.61	10.27	10.11	-0.050616946924612	5.18268784727992	0.484782135398859	0.81428008079208	6:149658152-149718256:-	LATS1	42;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000287,molecular_function magnesium ion binding;GO:0000819,biological_process sister chromatid segregation;GO:0000922,cellular_component spindle pole;GO:0001827,biological_process inner cell mass cell fate commitment;GO:0001828,biological_process inner cell mass cellular morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030216,biological_process keratinocyte differentiation;GO:0030331,molecular_function estrogen receptor binding;GO:0030833,biological_process regulation of actin filament polymerization;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0034613,biological_process cellular protein localization;GO:0035329,biological_process hippo signaling;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043254,biological_process regulation of protein complex assembly;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0046620,biological_process regulation of organ growth;GO:0046872,molecular_function metal ion binding;GO:0051220,biological_process cytoplasmic sequestering of protein;GO:0051301,biological_process cell division;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000058,biological_process regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	LATS1_2, Wts; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1]; K08791	large tumor suppressor kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:6514]
ENSG00000161016	1857.10	1752.69	1710.15	1859.30	1771.75	1891.13	-0.0420230098313382	10.4489453134664	0.484842026676409	0.81428008079208	8:144789764-144792587:-	RPL8	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015934,cellular_component large ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990932,molecular_function 5.8S rRNA binding	NA	ribosomal protein L8 [Source:HGNC Symbol%3BAcc:HGNC:10368]
ENSG00000204334	4.83	2.65	5.19	4.64	3.08	3.46	0.22644819445459	1.02697206549149	0.4849992578795	0.814433954012208	2:170783785-170798971:+	ERICH2	1;GO:0005515,molecular_function protein binding	NA	glutamate rich 2 [Source:HGNC Symbol%3BAcc:HGNC:44395]
ENSG00000100528	96.81	105.52	97.50	91.23	98.79	101.46	0.0487998396728798	5.62383420127267	0.485153206197128	0.814577560418204	14:54423559-54441431:-	CNIH1	14;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0048208,biological_process COPII vesicle coating	NA	cornichon family AMPA receptor auxiliary protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19431]
ENSG00000100749	14.30	16.08	14.44	16.94	14.46	15.86	-0.0707596665102533	4.46690999910521	0.485217031369074	0.814577560418204	14:96797303-96931722:+	VRK1	32;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005795,cellular_component Golgi stack;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0031493,molecular_function nucleosomal histone binding;GO:0035175,molecular_function histone kinase activity (H3-S10 specific);GO:0043987,biological_process histone H3-S10 phosphorylation;GO:0046777,biological_process protein autophosphorylation;GO:0051301,biological_process cell division;GO:0072354,molecular_function histone kinase activity (H3-T3 specific);GO:0072355,biological_process histone H3-T3 phosphorylation;GO:0090166,biological_process Golgi disassembly	NA	vaccinia related kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:12718]
ENSG00000103148	29.25	30.57	31.49	30.63	28.82	29.62	0.046875948095607	5.77524338649129	0.485281644992558	0.814577560418204	16:84270-138860:-	NPRL3	17;GO:0003281,biological_process ventricular septum development;GO:0003674,molecular_function molecular_function;GO:0005096,molecular_function GTPase activator activity;GO:0005575,cellular_component cellular_component;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0032007,biological_process negative regulation of TOR signaling;GO:0034198,biological_process cellular response to amino acid starvation;GO:0035909,biological_process aorta morphogenesis;GO:0038202,biological_process TORC1 signaling;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048738,biological_process cardiac muscle tissue development;GO:0060021,biological_process palate development;GO:1990130,cellular_component Iml1 complex;GO:2000785,biological_process regulation of autophagosome assembly	NA	NPR3 like%2C GATOR1 complex subunit [Source:HGNC Symbol%3BAcc:HGNC:14124]
ENSG00000170653	2.07	1.87	1.77	2.19	1.88	2.38	-0.163949277856344	1.71328796395505	0.485474135305415	0.814656617836368	12:53507855-53626410:-	ATF7	15;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0019899,molecular_function enzyme binding;GO:0034399,cellular_component nuclear periphery;GO:0046872,molecular_function metal ion binding;GO:0051019,molecular_function mitogen-activated protein kinase binding	NA	activating transcription factor 7 [Source:HGNC Symbol%3BAcc:HGNC:792]
ENSG00000129292	14.68	16.96	16.32	14.62	16.72	15.13	0.0542785633179814	5.68295495560116	0.485508372979967	0.814656617836368	8:132775357-132848807:+	PHF20L1	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	PHD finger protein 20 like 1 [Source:HGNC Symbol%3BAcc:HGNC:24280]
ENSG00000204536	31.11	28.16	30.04	31.78	28.88	32.57	-0.0485703317827349	6.38701228965222	0.485525631092681	0.814656617836368	6:31142438-31158238:-	CCHCR1	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0006611,biological_process protein export from nucleus;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation	NA	coiled-coil alpha-helical rod protein 1 [Source:HGNC Symbol%3BAcc:HGNC:13930]
ENSG00000143228	45.51	50.80	39.55	43.73	52.80	46.68	-0.0669384927017172	6.01891458109147	0.485825604116263	0.814823770732755	1:163266575-163355764:+	NUF2	15;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0016020,cellular_component membrane;GO:0031262,cellular_component Ndc80 complex;GO:0051301,biological_process cell division	NA	NUF2%2C NDC80 kinetochore complex component [Source:HGNC Symbol%3BAcc:HGNC:14621]
ENSG00000133943	27.59	32.06	30.70	29.36	35.35	30.11	-0.0594872403472532	6.33487829834317	0.485826911089515	0.814823770732755	14:91060332-91225632:+	C14orf159	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006536,biological_process glutamate metabolic process;GO:0008150,biological_process biological_process;GO:0016829,molecular_function lyase activity;GO:0047820,molecular_function D-glutamate cyclase activity	NA	chromosome 14 open reading frame 159 [Source:HGNC Symbol%3BAcc:HGNC:20498]
ENSG00000204116	5.10	4.51	6.19	6.40	4.14	7.26	-0.154338602208066	1.99459936236526	0.485852486443785	0.814823770732755	X:73563199-73687102:+	CHIC1	6;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle	NA	cysteine rich hydrophobic domain 1 [Source:HGNC Symbol%3BAcc:HGNC:1934]
ENSG00000075399	12.48	10.69	11.61	11.69	11.12	10.83	0.0666036909184744	4.44729085412802	0.485921414781179	0.814823770732755	16:89707133-89720986:-	VPS9D1	4;GO:0005096,molecular_function GTPase activator activity;GO:0005215,molecular_function transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0043547,biological_process positive regulation of GTPase activity	NA	VPS9 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:13526]
ENSG00000162066	10.11	9.26	8.67	8.57	10.14	8.05	0.0815686404300722	4.06552638014322	0.485992298909457	0.814823770732755	16:2520356-2531422:+	AMDHD2	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006046,biological_process N-acetylglucosamine catabolic process;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0008448,molecular_function N-acetylglucosamine-6-phosphate deacetylase activity;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0019262,biological_process N-acetylneuraminate catabolic process;GO:0046872,molecular_function metal ion binding	nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]; K01443	amidohydrolase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24262]
ENSG00000143418	156.36	137.31	147.43	151.40	136.62	142.13	0.0489324177683973	7.5785422922046	0.486077205657734	0.814823770732755	1:150960582-150975004:-	CERS2	15;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0031965,cellular_component nuclear membrane;GO:0046513,biological_process ceramide biosynthetic process;GO:0048681,biological_process negative regulation of axon regeneration;GO:0050291,molecular_function sphingosine N-acyltransferase activity;GO:1900148,biological_process negative regulation of Schwann cell migration;GO:1905045,biological_process negative regulation of Schwann cell proliferation involved in axon regeneration	CERS1_2_3_4, LASS1_2_3_4; ceramide synthetase [EC:2.3.1.24]; K04710	ceramide synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:14076]
ENSG00000141655	6.48	4.23	6.31	6.74	5.97	5.84	-0.0974810674305506	3.49050854780514	0.486084751653593	0.814823770732755	18:62325286-62391292:+	TNFRSF11A	39;GO:0001503,biological_process ossification;GO:0002250,biological_process adaptive immune response;GO:0002548,biological_process monocyte chemotaxis;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009314,biological_process response to radiation;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019955,molecular_function cytokine binding;GO:0030316,biological_process osteoclast differentiation;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034097,biological_process response to cytokine;GO:0034612,biological_process response to tumor necrosis factor;GO:0042981,biological_process regulation of apoptotic process;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0046872,molecular_function metal ion binding;GO:0048535,biological_process lymph node development;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060086,biological_process circadian temperature homeostasis;GO:0060749,biological_process mammary gland alveolus development;GO:0070555,biological_process response to interleukin-1;GO:0071812,biological_process positive regulation of fever generation by positive regulation of prostaglandin secretion;GO:0071847,biological_process TNFSF11-mediated signaling pathway;GO:0071848,biological_process positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling;GO:0097190,biological_process apoptotic signaling pathway	TNFRSF11A, RANK, CD265; tumor necrosis factor receptor superfamily member 11A; K05147	TNF receptor superfamily member 11a [Source:HGNC Symbol%3BAcc:HGNC:11908]
ENSG00000041982	14.07	10.89	13.52	15.56	11.29	14.11	-0.0766363195093212	6.51491808478282	0.486289278919394	0.814989513214153	9:115019577-115118257:-	TNC	34;GO:0001649,biological_process osteoblast differentiation;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005614,cellular_component interstitial matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007528,biological_process neuromuscular junction development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009611,biological_process response to wounding;GO:0009612,biological_process response to mechanical stimulus;GO:0010628,biological_process positive regulation of gene expression;GO:0014012,biological_process peripheral nervous system axon regeneration;GO:0016020,cellular_component membrane;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0031175,biological_process neuron projection development;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045471,biological_process response to ethanol;GO:0045545,molecular_function syndecan binding;GO:0060447,biological_process bud outgrowth involved in lung branching;GO:0060739,biological_process mesenchymal-epithelial cell signaling involved in prostate gland development;GO:0060740,biological_process prostate gland epithelium morphogenesis;GO:0071300,biological_process cellular response to retinoic acid;GO:0071305,biological_process cellular response to vitamin D;GO:0071774,biological_process response to fibroblast growth factor;GO:0071799,biological_process cellular response to prostaglandin D stimulus	TN; tenascin; K06252	tenascin C [Source:HGNC Symbol%3BAcc:HGNC:5318]
ENSG00000130985	93.69	105.23	90.18	92.85	99.27	89.10	0.0510049294760795	8.42390879853656	0.486314937918088	0.814989513214153	X:47190860-47215128:+	UBA1	23;GO:0000166,molecular_function nucleotide binding;GO:0000792,cellular_component heterochromatin;GO:0003723,molecular_function RNA binding;GO:0004839,molecular_function ubiquitin activating enzyme activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008641,molecular_function small protein activating enzyme activity;GO:0010008,cellular_component endosome membrane;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0016881,molecular_function acid-amino acid ligase activity;GO:0030057,cellular_component desmosome;GO:0030867,cellular_component rough endoplasmic reticulum membrane;GO:0070062,cellular_component extracellular exosome	UBE1, UBA1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]; K03178	ubiquitin like modifier activating enzyme 1 [Source:HGNC Symbol%3BAcc:HGNC:12469]
ENSG00000275410	88.12	97.73	89.66	85.23	101.38	79.73	0.06003384401138	7.31720314712744	0.486429557662055	0.815071557675362	17:37686431-37745247:-	HNF1B	59;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001159,molecular_function core promoter proximal region DNA binding;GO:0001714,biological_process endodermal cell fate specification;GO:0001822,biological_process kidney development;GO:0001826,biological_process inner cell mass cell differentiation;GO:0001889,biological_process liver development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007219,biological_process Notch signaling pathway;GO:0007492,biological_process endoderm development;GO:0009743,biological_process response to carbohydrate;GO:0009749,biological_process response to glucose;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010628,biological_process positive regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0030073,biological_process insulin secretion;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030902,biological_process hindbrain development;GO:0032403,molecular_function protein complex binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0035565,biological_process regulation of pronephros size;GO:0039020,biological_process pronephric nephron tubule development;GO:0042493,biological_process response to drug;GO:0042663,biological_process regulation of endodermal cell fate specification;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048598,biological_process embryonic morphogenesis;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048793,biological_process pronephros development;GO:0050673,biological_process epithelial cell proliferation;GO:0060261,biological_process positive regulation of transcription initiation from RNA polymerase II promoter;GO:0060429,biological_process epithelium development;GO:0060677,biological_process ureteric bud elongation;GO:0060993,biological_process kidney morphogenesis;GO:0061017,biological_process hepatoblast differentiation;GO:0061296,biological_process negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis;GO:0065004,biological_process protein-DNA complex assembly;GO:0070365,biological_process hepatocyte differentiation;GO:0072095,biological_process regulation of branch elongation involved in ureteric bud branching;GO:0072164,biological_process mesonephric tubule development;GO:0072176,biological_process nephric duct development;GO:0072177,biological_process mesonephric duct development;GO:0072179,biological_process nephric duct formation;GO:0072181,biological_process mesonephric duct formation;GO:1900212,biological_process negative regulation of mesenchymal cell apoptotic process involved in metanephros development	TCF2, HNF1B; transcription factor 2, hepatocyte nuclear factor 1-beta; K08034	HNF1 homeobox B [Source:HGNC Symbol%3BAcc:HGNC:11630]
ENSG00000174282	21.87	22.86	23.66	23.43	21.29	21.98	0.04747174441023	6.10023746264513	0.486749967203576	0.81539121835297	17:7459365-7484263:-	ZBTB4	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008327,molecular_function methyl-CpG binding;GO:0010428,molecular_function methyl-CpNpG binding;GO:0016604,cellular_component nuclear body;GO:0019901,molecular_function protein kinase binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:23847]
ENSG00000137285	1.85	2.51	2.26	2.58	2.39	2.42	-0.163294582861859	1.70355289666449	0.486751706114195	0.81539121835297	6:3224260-3231730:-	TUBB2B	16;GO:0000166,molecular_function nucleotide binding;GO:0001764,biological_process neuron migration;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0007399,biological_process nervous system development;GO:0015630,cellular_component microtubule cytoskeleton;GO:0046982,molecular_function protein heterodimerization activity;GO:1902669,biological_process positive regulation of axon guidance	TUBB; tubulin beta; K07375	tubulin beta 2B class IIb [Source:HGNC Symbol%3BAcc:HGNC:30829]
ENSG00000163171	73.13	62.96	79.11	75.07	64.70	68.47	0.0631688096597142	5.75612378939774	0.487029258426329	0.815643411970263	2:37641881-37738468:-	CDC42EP3	16;GO:0005096,molecular_function GTPase activator activity;GO:0005519,molecular_function cytoskeletal regulatory protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0012505,cellular_component endomembrane system;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0017049,molecular_function GTP-Rho binding;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0043547,biological_process positive regulation of GTPase activity	NA	CDC42 effector protein 3 [Source:HGNC Symbol%3BAcc:HGNC:16943]
ENSG00000136856	6.84	6.51	7.78	7.76	7.13	7.77	-0.0838600054020645	3.44555351801414	0.48703367191844	0.815643411970263	9:127397137-127408424:+	SLC2A8	29;GO:0001666,biological_process response to hypoxia;GO:0005215,molecular_function transporter activity;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005536,molecular_function glucose binding;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006810,biological_process transport;GO:0007141,biological_process male meiosis I;GO:0008021,cellular_component synaptic vesicle;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008643,biological_process carbohydrate transport;GO:0008645,biological_process hexose transport;GO:0015758,biological_process glucose transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0046323,biological_process glucose import;GO:0055056,molecular_function D-glucose transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0061024,biological_process membrane organization;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 2 member 8 [Source:HGNC Symbol%3BAcc:HGNC:13812]
ENSG00000120068	19.30	17.33	16.86	17.33	15.30	18.54	0.0768681783016674	3.88721612012861	0.487292173817004	0.815895135862231	17:48611376-48614939:-	HOXB8	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007625,biological_process grooming behavior;GO:0008344,biological_process adult locomotory behavior;GO:0009952,biological_process anterior/posterior pattern specification;GO:0019233,biological_process sensory perception of pain;GO:0021516,biological_process dorsal spinal cord development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048705,biological_process skeletal system morphogenesis	NA	homeobox B8 [Source:HGNC Symbol%3BAcc:HGNC:5119]
ENSG00000166847	25.48	24.58	24.53	27.95	28.31	22.82	-0.0696843629316082	4.37012280337227	0.487315438434108	0.815895135862231	16:23641391-23677455:+	DCTN5	16;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003281,biological_process ventricular septum development;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0031965,cellular_component nuclear membrane;GO:0035904,biological_process aorta development;GO:0060976,biological_process coronary vasculature development	DCTN5; dynactin 5; K10427	dynactin subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:24594]
ENSG00000176595	1.55	1.38	0.95	0.96	1.01	1.43	0.188178569245187	1.27457429443342	0.487417793087367	0.815956448495413	8:1973877-2006936:+	KBTBD11	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch repeat and BTB domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:29104]
ENSG00000153037	45.34	45.35	40.85	39.18	46.44	40.67	0.0693075127571955	4.35173461725725	0.487546035198588	0.816061075366785	5:112861221-112869788:+	SRP19	14;GO:0003723,molecular_function RNA binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005786,cellular_component signal recognition particle, endoplasmic reticulum targeting;GO:0005829,cellular_component cytosol;GO:0006613,biological_process cotranslational protein targeting to membrane;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006616,biological_process SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0006617,biological_process SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0008312,molecular_function 7S RNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042493,biological_process response to drug;GO:0043022,molecular_function ribosome binding;GO:0048500,cellular_component signal recognition particle	SRP19; signal recognition particle subunit SRP19; K03105	signal recognition particle 19 [Source:HGNC Symbol%3BAcc:HGNC:11300]
ENSG00000092853	5.09	5.91	4.99	4.91	5.34	5.11	0.0625882593030604	4.42880073321807	0.487782517521239	0.816180944958439	1:35720217-35769967:-	CLSPN	17;GO:0000077,biological_process DNA damage checkpoint;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0010997,molecular_function anaphase-promoting complex binding;GO:0016579,biological_process protein deubiquitination;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0032147,biological_process activation of protein kinase activity;GO:0033314,biological_process mitotic DNA replication checkpoint;GO:0097194,biological_process execution phase of apoptosis	NA	claspin [Source:HGNC Symbol%3BAcc:HGNC:19715]
ENSG00000144659	28.33	26.03	29.83	30.11	28.56	29.85	-0.0556304780150852	4.76952044624674	0.487851674976933	0.816180944958439	3:39383347-39397351:+	SLC25A38	11;GO:0005215,molecular_function transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006783,biological_process heme biosynthetic process;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0015187,molecular_function glycine transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030218,biological_process erythrocyte differentiation;GO:0036233,biological_process glycine import	NA	solute carrier family 25 member 38 [Source:HGNC Symbol%3BAcc:HGNC:26054]
ENSG00000242259	11.39	10.10	10.02	11.41	10.60	12.35	-0.109580388226937	2.65603414274929	0.487906543017085	0.816180944958439	22:19351367-19448232:-	C22orf39	1;GO:0005515,molecular_function protein binding	NA	chromosome 22 open reading frame 39 [Source:HGNC Symbol%3BAcc:HGNC:27012]
ENSG00000141376	5.09	5.25	5.51	5.44	5.86	5.43	-0.0659889000851171	4.16584493870927	0.487934650252764	0.816180944958439	17:60677452-61392838:+	BCAS3	37;GO:0001525,biological_process angiogenesis;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007030,biological_process Golgi organization;GO:0008134,molecular_function transcription factor binding;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010698,molecular_function acetyltransferase activator activity;GO:0016192,biological_process vesicle-mediated transport;GO:0031023,biological_process microtubule organizing center organization;GO:0031252,cellular_component cell leading edge;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035148,biological_process tube formation;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035327,cellular_component transcriptionally active chromatin;GO:0042393,molecular_function histone binding;GO:0042594,biological_process response to starvation;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048487,molecular_function beta-tubulin binding;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0071391,biological_process cellular response to estrogen stimulus;GO:0071944,cellular_component cell periphery;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0090630,biological_process activation of GTPase activity;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization	NA	BCAS3%2C microtubule associated cell migration factor [Source:HGNC Symbol%3BAcc:HGNC:14347]
ENSG00000240857	14.43	13.75	12.27	13.59	15.65	13.81	-0.0781344974255163	3.82656761747375	0.487946410419446	0.816180944958439	2:18554722-18560680:-	RDH14	12;GO:0001649,biological_process osteoblast differentiation;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008106,molecular_function alcohol dehydrogenase (NADP+) activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0042572,biological_process retinol metabolic process;GO:0052650,molecular_function NADP-retinol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process	NA	retinol dehydrogenase 14 (all-trans/9-cis/11-cis) [Source:HGNC Symbol%3BAcc:HGNC:19979]
ENSG00000040487	14.03	14.63	15.74	14.80	14.58	13.13	0.0766022726361192	3.75352780683991	0.48803650198845	0.816221651735735	1:19312325-19329300:+	PQLC2	18;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015174,molecular_function basic amino acid transmembrane transporter activity;GO:0015181,molecular_function arginine transmembrane transporter activity;GO:0015189,molecular_function L-lysine transmembrane transporter activity;GO:0015809,biological_process arginine transport;GO:0015819,biological_process lysine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031301,cellular_component integral component of organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055085,biological_process transmembrane transport;GO:0080144,biological_process amino acid homeostasis;GO:1903401,biological_process L-lysine transmembrane transport;GO:1903826,biological_process arginine transmembrane transport;GO:1990822,biological_process basic amino acid transmembrane transport	NA	PQ loop repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26001]
ENSG00000112697	99.91	110.21	91.88	91.67	103.92	97.46	0.0532559427411848	6.74858503411308	0.488256620752103	0.816479783564038	6:75252923-75284968:-	TMEM30A	20;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0006869,biological_process lipid transport;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030658,cellular_component transport vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0036010,biological_process protein localization to endosome;GO:0043312,biological_process neutrophil degranulation;GO:0045332,biological_process phospholipid translocation;GO:0070863,biological_process positive regulation of protein exit from endoplasmic reticulum	NA	transmembrane protein 30A [Source:HGNC Symbol%3BAcc:HGNC:16667]
ENSG00000124279	12.27	12.47	13.55	12.86	13.50	13.82	-0.0568449484597545	4.79422056928309	0.488373812610861	0.816525868661095	5:7859158-7869037:-	FASTKD3	7;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006468,biological_process protein phosphorylation;GO:0045333,biological_process cellular respiration	NA	FAST kinase domains 3 [Source:HGNC Symbol%3BAcc:HGNC:28758]
ENSG00000125734	54.55	54.72	57.10	59.25	54.02	59.99	-0.0467273944481822	6.67185203815568	0.488478164055818	0.816525868661095	19:6729913-6737603:-	GPR108	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 108 [Source:HGNC Symbol%3BAcc:HGNC:17829]
ENSG00000100416	27.40	25.65	28.03	24.60	25.64	28.45	0.0569201038823439	5.08064054241871	0.488616589347197	0.816525868661095	22:46330874-46357340:+	TRMU	13;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0002143,biological_process tRNA wobble position uridine thiolation;GO:0003723,molecular_function RNA binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016783,molecular_function sulfurtransferase activity;GO:0032259,biological_process methylation;GO:0070903,biological_process mitochondrial tRNA thio-modification	mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]; K00566	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:25481]
ENSG00000163870	38.77	40.71	38.97	43.24	36.84	43.93	-0.0569468198466522	5.50840646821732	0.48861838259046	0.816525868661095	3:127573068-127598251:-	TPRA1	8;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0006629,biological_process lipid metabolic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007568,biological_process aging;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0040016,biological_process embryonic cleavage;GO:1901991,biological_process negative regulation of mitotic cell cycle phase transition	NA	transmembrane protein adipocyte associated 1 [Source:HGNC Symbol%3BAcc:HGNC:30413]
ENSG00000120889	47.78	44.45	48.96	50.82	43.72	53.43	-0.0546769289025318	5.9972195114826	0.488694887218076	0.816525868661095	8:23020132-23069179:-	TNFRSF10B	32;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0007275,biological_process multicellular organism development;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045569,molecular_function TRAIL binding;GO:0050900,biological_process leukocyte migration;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B; K04722	TNF receptor superfamily member 10b [Source:HGNC Symbol%3BAcc:HGNC:11905]
ENSG00000175166	89.44	103.43	85.01	93.70	99.54	97.23	-0.0531566414748394	8.06203547534184	0.488752316648152	0.816525868661095	3:184298708-184309054:+	PSMD2	43;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0030234,molecular_function enzyme regulator activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034515,cellular_component proteasome storage granule;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042176,biological_process regulation of protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050790,biological_process regulation of catalytic activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD2, RPN1; 26S proteasome regulatory subunit N1; K03028	proteasome 26S subunit%2C non-ATPase 2 [Source:HGNC Symbol%3BAcc:HGNC:9559]
ENSG00000278540	30.23	34.70	29.97	29.82	32.46	30.05	0.0502540107834707	7.85960035725268	0.488790036608838	0.816525868661095	17:37084987-37406818:-	ACACA	30;GO:0000166,molecular_function nucleotide binding;GO:0001650,cellular_component fibrillar center;GO:0001894,biological_process tissue homeostasis;GO:0003824,molecular_function catalytic activity;GO:0003989,molecular_function acetyl-CoA carboxylase activity;GO:0004075,molecular_function biotin carboxylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006084,biological_process acetyl-CoA metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006768,biological_process biotin metabolic process;GO:0006853,biological_process carnitine shuttle;GO:0008152,biological_process metabolic process;GO:0015629,cellular_component actin cytoskeleton;GO:0016874,molecular_function ligase activity;GO:0031325,biological_process positive regulation of cellular metabolic process;GO:0044268,biological_process multicellular organismal protein metabolic process;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0051289,biological_process protein homotetramerization;GO:0055088,biological_process lipid homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:2001295,biological_process malonyl-CoA biosynthetic process	ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]; K11262	acetyl-CoA carboxylase alpha [Source:HGNC Symbol%3BAcc:HGNC:84]
ENSG00000121022	108.71	104.25	100.30	102.36	106.30	118.05	-0.0489393213884262	6.92001244461482	0.48887125382776	0.816525868661095	8:67043078-67083783:-	COPS5	37;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000785,cellular_component chromatin;GO:0003713,molecular_function transcription coactivator activity;GO:0003743,molecular_function translation initiation factor activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006508,biological_process proteolysis;GO:0008021,cellular_component synaptic vesicle;GO:0008180,cellular_component COP9 signalosome;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019784,molecular_function NEDD8-specific protease activity;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042981,biological_process regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0045202,cellular_component synapse;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046328,biological_process regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051726,biological_process regulation of cell cycle;GO:1903894,biological_process regulation of IRE1-mediated unfolded protein response;GO:1990182,biological_process exosomal secretion	NA	COP9 signalosome subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:2240]
ENSG00000185658	7.84	7.93	8.53	8.67	8.39	8.24	-0.0461068592393136	5.90697163305367	0.488912758758363	0.816525868661095	21:39184175-39321559:-	BRWD1	13;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0038111,biological_process interleukin-7-mediated signaling pathway	NA	bromodomain and WD repeat domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:12760]
ENSG00000089091	3.65	3.80	4.32	3.99	4.85	3.86	-0.0957523220726094	3.33753024935457	0.488941978712473	0.816525868661095	20:18383366-18467281:-	DZANK1	1;GO:0046872,molecular_function metal ion binding	NA	double zinc ribbon and ankyrin repeat domains 1 [Source:HGNC Symbol%3BAcc:HGNC:15858]
ENSG00000213246	83.75	83.51	80.69	88.95	92.89	78.22	-0.0563841502226569	5.21250314326651	0.489112488389401	0.816700742316066	17:58345174-58353093:-	SUPT4H1	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0032044,cellular_component DSIF complex;GO:0032785,biological_process negative regulation of DNA-templated transcription, elongation;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0034243,biological_process regulation of transcription elongation from RNA polymerase II promoter;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050434,biological_process positive regulation of viral transcription	NA	SPT4 homolog%2C DSIF elongation factor subunit [Source:HGNC Symbol%3BAcc:HGNC:11467]
ENSG00000149269	27.01	27.87	27.35	26.97	25.28	27.89	0.0469131541613746	5.57225081331826	0.489275925426732	0.81680163314892	11:77321706-77474635:-	PAK1	74;GO:0000166,molecular_function nucleotide binding;GO:0001666,biological_process response to hypoxia;GO:0001726,cellular_component ruffle;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003824,molecular_function catalytic activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006887,biological_process exocytosis;GO:0006915,biological_process apoptotic process;GO:0007266,biological_process Rho protein signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008152,biological_process metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010033,biological_process response to organic substance;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0021549,biological_process cerebellum development;GO:0030010,biological_process establishment of cell polarity;GO:0030018,cellular_component Z disc;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031295,biological_process T cell costimulation;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031941,cellular_component filamentous actin;GO:0031965,cellular_component nuclear membrane;GO:0032147,biological_process activation of protein kinase activity;GO:0032587,cellular_component ruffle membrane;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042060,biological_process wound healing;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045773,biological_process positive regulation of axon extension;GO:0046777,biological_process protein autophosphorylation;GO:0048012,biological_process hepatocyte growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048812,biological_process neuron projection morphogenesis;GO:0050770,biological_process regulation of axonogenesis;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0060244,biological_process negative regulation of cell proliferation involved in contact inhibition;GO:0061052,biological_process negative regulation of cell growth involved in cardiac muscle cell development;GO:0071437,cellular_component invadopodium;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	PAK1; p21-activated kinase 1 [EC:2.7.11.1]; K04409	p21 (RAC1) activated kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:8590]
ENSG00000141026	13.20	14.54	10.08	12.21	14.01	15.13	-0.130105279733916	2.63448578717102	0.489346886484034	0.81680163314892	17:17476985-17493226:+	MED9	7;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016592,cellular_component mediator complex	NA	mediator complex subunit 9 [Source:HGNC Symbol%3BAcc:HGNC:25487]
ENSG00000146242	57.45	54.23	63.50	60.97	47.37	60.55	0.065564226989716	6.18020240715266	0.489457105260502	0.81680163314892	6:82363205-82370828:+	TPBG	9;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051965,biological_process positive regulation of synapse assembly	NA	trophoblast glycoprotein [Source:HGNC Symbol%3BAcc:HGNC:12004]
ENSG00000120265	79.89	78.36	78.75	82.62	81.29	82.31	-0.0429814435451134	6.39745409420308	0.489611088249945	0.81680163314892	6:149749442-149811420:+	PCMT1	15;GO:0004719,molecular_function protein-L-isoaspartate (D-aspartate) O-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030091,biological_process protein repair;GO:0032259,biological_process methylation;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	NA	protein-L-isoaspartate (D-aspartate) O-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:8728]
ENSG00000197885	21.19	22.41	22.08	21.43	18.57	22.55	0.0774869381191416	3.64895912528916	0.489634020114338	0.81680163314892	3:23891659-23946591:-	NKIRAS1	8;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0016020,cellular_component membrane	NA	NFKB inhibitor interacting Ras like 1 [Source:HGNC Symbol%3BAcc:HGNC:17899]
ENSG00000099940	41.43	36.79	38.80	41.98	35.67	35.43	0.0651888300415028	4.90095872295666	0.48970274632887	0.81680163314892	22:20858982-20891218:+	SNAP29	34;GO:0000139,cellular_component Golgi membrane;GO:0000421,cellular_component autophagosome membrane;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006903,biological_process vesicle targeting;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016082,biological_process synaptic vesicle priming;GO:0016240,biological_process autophagosome docking;GO:0019905,molecular_function syntaxin binding;GO:0020018,cellular_component ciliary pocket membrane;GO:0030030,biological_process cell projection organization;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0042995,cellular_component cell projection;GO:0043312,biological_process neutrophil degranulation;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0061025,biological_process membrane fusion;GO:0097352,biological_process autophagosome maturation;GO:0098793,cellular_component presynapse	SNAP29; synaptosomal-associated protein 29; K08509	synaptosome associated protein 29 [Source:HGNC Symbol%3BAcc:HGNC:11133]
ENSG00000139719	1.08	1.16	0.43	1.34	1.36	0.52	-0.269830219798021	0.993169056837301	0.489741539707615	0.81680163314892	12:122229563-122266521:-	VPS33A	27;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0006810,biological_process transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006914,biological_process autophagy;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030220,biological_process platelet formation;GO:0030897,cellular_component HOPS complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0032400,biological_process melanosome localization;GO:0032418,biological_process lysosome localization;GO:0035751,biological_process regulation of lysosomal lumen pH;GO:0048070,biological_process regulation of developmental pigmentation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071439,cellular_component clathrin complex;GO:0097352,biological_process autophagosome maturation	NA	VPS33A%2C CORVET/HOPS core subunit [Source:HGNC Symbol%3BAcc:HGNC:18179]
ENSG00000130856	3.49	4.09	3.01	3.53	3.25	3.29	0.0756134797980111	4.30638545573001	0.489822043061336	0.81680163314892	18:76822606-76970727:+	ZNF236	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0071333,biological_process cellular response to glucose stimulus	NA	zinc finger protein 236 [Source:HGNC Symbol%3BAcc:HGNC:13028]
ENSG00000117151	31.72	29.25	34.03	32.88	27.35	31.70	0.0620312738215704	5.24375747934999	0.489833462684306	0.81680163314892	1:84549605-84574480:-	CTBS	12;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004568,molecular_function chitinase activity;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0006032,biological_process chitin catabolic process;GO:0008061,molecular_function chitin binding;GO:0008152,biological_process metabolic process;GO:0009313,biological_process oligosaccharide catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0070062,cellular_component extracellular exosome	NA	chitobiase [Source:HGNC Symbol%3BAcc:HGNC:2496]
ENSG00000085840	4.32	4.99	3.99	5.30	4.32	4.63	-0.0966380787120288	3.58319410950852	0.489979040850687	0.81680163314892	1:52372828-52404459:-	ORC1	17;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000808,cellular_component origin recognition complex;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation	ORC1; origin recognition complex subunit 1; K02603	origin recognition complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:8487]
ENSG00000093167	30.69	29.69	30.96	30.11	31.17	33.87	-0.0466825218902538	6.0761150616625	0.489983006567984	0.81680163314892	3:37052655-37183689:-	LRRFIP2	6;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0016055,biological_process Wnt signaling pathway;GO:0030275,molecular_function LRR domain binding	NA	LRR binding FLII interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6703]
ENSG00000164823	42.86	40.01	39.08	37.25	40.04	41.64	0.0483606874204493	6.05246790001475	0.490021307465852	0.81680163314892	8:89901858-89927888:+	OSGIN2	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008083,molecular_function growth factor activity;GO:0016491,molecular_function oxidoreductase activity;GO:0030308,biological_process negative regulation of cell growth;GO:0051321,biological_process meiotic cell cycle;GO:0055114,biological_process oxidation-reduction process	NA	oxidative stress induced growth inhibitor family member 2 [Source:HGNC Symbol%3BAcc:HGNC:1355]
ENSG00000153391	7.02	8.87	6.19	8.17	7.78	7.91	-0.11845757216891	2.83363878210124	0.490034534406005	0.81680163314892	18:35452229-35497991:-	INO80C	14;GO:0001650,cellular_component fibrillar center;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008150,biological_process biological_process;GO:0016579,biological_process protein deubiquitination;GO:0031011,cellular_component Ino80 complex;GO:0071339,cellular_component MLL1 complex	NA	INO80 complex subunit C [Source:HGNC Symbol%3BAcc:HGNC:26994]
ENSG00000239264	199.83	205.44	183.83	185.85	193.29	196.63	0.0442213016753256	7.97661573790771	0.490102796784706	0.81680163314892	6:7881516-7910814:-	TXNDC5	16;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006457,biological_process protein folding;GO:0016853,molecular_function isomerase activity;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035578,cellular_component azurophil granule lumen;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043202,cellular_component lysosomal lumen;GO:0043277,biological_process apoptotic cell clearance;GO:0043312,biological_process neutrophil degranulation;GO:0045454,biological_process cell redox homeostasis;GO:0070062,cellular_component extracellular exosome	TXNDC5, ERP46; thioredoxin domain-containing protein 5; K13984	thioredoxin domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:21073]
ENSG00000157999	3.77	3.51	4.05	4.42	4.17	3.81	-0.109981443364803	2.35845678946767	0.490159942425385	0.81680163314892	7:6031375-6036386:+	ANKRD61	NA	NA	ankyrin repeat domain 61 [Source:HGNC Symbol%3BAcc:HGNC:22467]
ENSG00000134318	11.40	11.37	11.10	11.01	11.88	12.43	-0.0494538946242254	5.5930707944429	0.490425050031327	0.817133710877699	2:11179760-11348330:-	ROCK2	54;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006939,biological_process smooth muscle contraction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007266,biological_process Rho protein signal transduction;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0010825,biological_process positive regulation of centrosome duplication;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016740,molecular_function transferase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030155,biological_process regulation of cell adhesion;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035509,biological_process negative regulation of myosin-light-chain-phosphatase activity;GO:0035556,biological_process intracellular signal transduction;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0039694,biological_process viral RNA genome replication;GO:0042752,biological_process regulation of circadian rhythm;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048511,biological_process rhythmic process;GO:0051298,biological_process centrosome duplication;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0071394,biological_process cellular response to testosterone stimulus;GO:0072518,molecular_function Rho-dependent protein serine/threonine kinase activity;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:1903140,biological_process regulation of establishment of endothelial barrier;GO:1903347,biological_process negative regulation of bicellular tight junction assembly;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000145,biological_process regulation of cell motility	ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]; K17388	Rho associated coiled-coil containing protein kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:10252]
ENSG00000172260	1.33	1.17	1.18	1.27	1.86	1.26	-0.229164336473111	0.662870436764511	0.49076189214764	0.817585205640674	1:71395939-72282734:-	NEGR1	12;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007155,biological_process cell adhesion;GO:0007626,biological_process locomotory behavior;GO:0007631,biological_process feeding behavior;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0031225,cellular_component anchored component of membrane;GO:0070062,cellular_component extracellular exosome	NEGR1; neuronal growth regulator 1; K06775	neuronal growth regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:17302]
ENSG00000088930	60.99	62.10	62.73	64.49	64.51	63.71	-0.0408681606917299	7.49238515958722	0.490903964973942	0.817674411173597	20:21303303-21389827:+	XRN2	33;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000738,biological_process DNA catabolic process, exonucleolytic;GO:0001147,molecular_function transcription termination site sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004534,molecular_function 5'-3' exoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006401,biological_process RNA catabolic process;GO:0007283,biological_process spermatogenesis;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016070,biological_process RNA metabolic process;GO:0016235,cellular_component aggresome;GO:0016787,molecular_function hydrolase activity;GO:0021766,biological_process hippocampus development;GO:0030182,biological_process neuron differentiation;GO:0046872,molecular_function metal ion binding;GO:0060041,biological_process retina development in camera-type eye;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-]; K12619	5'-3' exoribonuclease 2 [Source:HGNC Symbol%3BAcc:HGNC:12836]
ENSG00000169084	18.41	19.84	17.93	17.71	17.70	18.83	0.0567399956176013	4.56713364767712	0.490947183314011	0.817674411173597	X:2219515-2502805:-	DHRSX	4;GO:0005576,cellular_component extracellular region;GO:0010508,biological_process positive regulation of autophagy;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	dehydrogenase/reductase X-linked [Source:HGNC Symbol%3BAcc:HGNC:18399]
ENSG00000145592	2506.25	2256.68	2426.38	2597.08	2320.23	2567.57	-0.0462023235266129	9.65341390436742	0.4912238853827	0.818025501644144	5:40825261-40835335:-	RPL37	15;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0046872,molecular_function metal ion binding	NA	ribosomal protein L37 [Source:HGNC Symbol%3BAcc:HGNC:10347]
ENSG00000088298	31.24	34.06	30.35	30.70	32.15	30.25	0.0474069169450508	5.77258599106672	0.491524522723694	0.818361993954368	20:35115356-35147364:-	EDEM2	16;GO:0004571,molecular_function mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006491,biological_process N-glycan processing;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0036509,biological_process trimming of terminal mannose on B branch;GO:0036510,biological_process trimming of terminal mannose on C branch;GO:0036511,biological_process trimming of first mannose on A branch;GO:0036512,biological_process trimming of second mannose on A branch;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0097466,biological_process glycoprotein ERAD pathway;GO:1904154,biological_process positive regulation of retrograde protein transport, ER to cytosol;GO:1904382,biological_process mannose trimming involved in glycoprotein ERAD pathway	EDEM2; ER degradation enhancer, mannosidase alpha-like 2; K10085	ER degradation enhancing alpha-mannosidase like protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15877]
ENSG00000149231	31.92	25.57	28.94	27.56	26.75	29.54	0.0602157097479489	5.54265708786802	0.491557804473034	0.818361993954368	11:96352768-96389923:-	CCDC82	NA	NA	coiled-coil domain containing 82 [Source:HGNC Symbol%3BAcc:HGNC:26282]
ENSG00000163638	15.72	18.78	14.76	14.40	17.57	15.45	0.0640320278222877	6.54866854673375	0.491714762841006	0.818513524359047	3:64515653-64688000:-	ADAMTS9	21;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0006508,biological_process proteolysis;GO:0006516,biological_process glycoprotein catabolic process;GO:0006810,biological_process transport;GO:0007275,biological_process multicellular organism development;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009986,cellular_component cell surface;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0016787,molecular_function hydrolase activity;GO:0031012,cellular_component extracellular matrix;GO:0045636,biological_process positive regulation of melanocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0048070,biological_process regulation of developmental pigmentation	NA	ADAM metallopeptidase with thrombospondin type 1 motif 9 [Source:HGNC Symbol%3BAcc:HGNC:13202]
ENSG00000182628	62.18	64.59	63.14	62.67	65.33	56.30	0.0547554258129901	5.17493330482108	0.491924675040552	0.818523808724183	17:59109950-59155269:-	SKA2	19;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0008017,molecular_function microtubule binding;GO:0031110,biological_process regulation of microtubule polymerization or depolymerization;GO:0051301,biological_process cell division	NA	spindle and kinetochore associated complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:28006]
ENSG00000158301	6.74	5.78	5.83	5.54	5.10	6.80	0.0868437653025678	3.92500113593896	0.491956343658056	0.818523808724183	X:102712175-102717733:+	GPRASP2	3;GO:0001540,molecular_function beta-amyloid binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm	NA	G protein-coupled receptor associated sorting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:25169]
ENSG00000114353	265.32	285.26	263.94	257.62	281.86	256.17	0.0451792526651646	8.4097259874975	0.491967165675003	0.818523808724183	3:50226291-50259355:+	GNAI2	43;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001973,biological_process adenosine receptor signaling pathway;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007194,biological_process negative regulation of adenylate cyclase activity;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007214,biological_process gamma-aminobutyric acid signaling pathway;GO:0007584,biological_process response to nutrient;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0030425,cellular_component dendrite;GO:0030496,cellular_component midbody;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0035556,biological_process intracellular signal transduction;GO:0044297,cellular_component cell body;GO:0045121,cellular_component membrane raft;GO:0046872,molecular_function metal ion binding;GO:0050805,biological_process negative regulation of synaptic transmission;GO:0051301,biological_process cell division;GO:0051924,biological_process regulation of calcium ion transport;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle	GNAI; guanine nucleotide-binding protein G(i) subunit alpha; K04630	G protein subunit alpha i2 [Source:HGNC Symbol%3BAcc:HGNC:4385]
ENSG00000109919	67.05	79.69	66.64	71.33	70.00	65.37	0.0536369957622759	5.99355940350747	0.491984704494572	0.818523808724183	11:47617314-47642623:-	MTCH2	9;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043065,biological_process positive regulation of apoptotic process;GO:0070062,cellular_component extracellular exosome;GO:0070585,biological_process protein localization to mitochondrion	NA	mitochondrial carrier 2 [Source:HGNC Symbol%3BAcc:HGNC:17587]
ENSG00000187867	1.01	1.37	1.17	0.41	1.62	0.98	0.248771465072353	1.22211023872044	0.49218554443456	0.818700973314091	19:14053364-14059159:-	PALM3	9;GO:0000166,molecular_function nucleotide binding;GO:0001960,biological_process negative regulation of cytokine-mediated signaling pathway;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0008063,biological_process Toll signaling pathway;GO:0016020,cellular_component membrane;GO:0032496,biological_process response to lipopolysaccharide	NA	paralemmin 3 [Source:HGNC Symbol%3BAcc:HGNC:33274]
ENSG00000196074	0.35	0.65	0.71	0.57	0.43	0.49	0.189287114270285	1.36391227254052	0.492301432937371	0.818700973314091	20:59863562-59933655:-	SYCP2	16;GO:0000795,cellular_component synaptonemal complex;GO:0000800,cellular_component lateral element;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0007049,biological_process cell cycle;GO:0007130,biological_process synaptonemal complex assembly;GO:0007140,biological_process male meiosis;GO:0007143,biological_process female meiotic division;GO:0009566,biological_process fertilization;GO:0009887,biological_process organ morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0048808,biological_process male genitalia morphogenesis;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle	NA	synaptonemal complex protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11490]
ENSG00000100823	169.05	181.80	165.60	165.24	176.72	162.27	0.0453803952449331	7.44623871182978	0.49238100174621	0.818700973314091	14:20455190-20457772:+	APEX1	67;GO:0000723,biological_process telomere maintenance;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004528,molecular_function phosphodiesterase I activity;GO:0004844,molecular_function uracil DNA N-glycosylase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005813,cellular_component centrosome;GO:0005840,cellular_component ribosome;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006286,biological_process base-excision repair, base-free sugar-phosphate removal;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007568,biological_process aging;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008309,molecular_function double-stranded DNA exodeoxyribonuclease activity;GO:0008311,molecular_function double-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0010243,biological_process response to organonitrogen compound;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016491,molecular_function oxidoreductase activity;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016829,molecular_function lyase activity;GO:0016890,molecular_function site-specific endodeoxyribonuclease activity, specific for altered base;GO:0031490,molecular_function chromatin DNA binding;GO:0032403,molecular_function protein complex binding;GO:0042493,biological_process response to drug;GO:0042981,biological_process regulation of apoptotic process;GO:0043488,biological_process regulation of mRNA stability;GO:0045454,biological_process cell redox homeostasis;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051059,molecular_function NF-kappaB binding;GO:0055114,biological_process oxidation-reduction process;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071320,biological_process cellular response to cAMP;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071417,biological_process cellular response to organonitrogen compound;GO:0080111,biological_process DNA demethylation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0097698,biological_process telomere maintenance via base-excision repair;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	APEX1; AP endonuclease 1 [EC:4.2.99.18]; K10771	apurinic/apyrimidinic endodeoxyribonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:587]
ENSG00000118961	20.66	20.30	19.77	19.25	22.30	22.25	-0.0597892871248168	4.762518894599	0.492412131231571	0.818700973314091	2:20684013-20823130:-	LDAH	7;GO:0005783,cellular_component endoplasmic reticulum;GO:0005811,cellular_component lipid particle;GO:0006629,biological_process lipid metabolic process;GO:0016042,biological_process lipid catabolic process;GO:0016298,molecular_function lipase activity;GO:0016787,molecular_function hydrolase activity;GO:0019915,biological_process lipid storage	NA	lipid droplet associated hydrolase [Source:HGNC Symbol%3BAcc:HGNC:26145]
ENSG00000122299	32.85	28.54	32.21	32.15	31.14	34.50	-0.0489642761661251	6.5426767318572	0.492420967273262	0.818700973314091	16:11750585-11797267:-	ZC3H7A	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 7A [Source:HGNC Symbol%3BAcc:HGNC:30959]
ENSG00000108443	18.55	17.20	17.70	18.37	18.47	19.12	-0.0518151722060642	4.89630007078658	0.492526519414123	0.818766798645709	17:59893045-59950564:+	RPS6KB1	77;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0001662,biological_process behavioral fear response;GO:0003009,biological_process skeletal muscle contraction;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004711,molecular_function ribosomal protein S6 kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007281,biological_process germ cell development;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0007616,biological_process long-term memory;GO:0009408,biological_process response to heat;GO:0009611,biological_process response to wounding;GO:0009612,biological_process response to mechanical stimulus;GO:0009636,biological_process response to toxic substance;GO:0009749,biological_process response to glucose;GO:0009986,cellular_component cell surface;GO:0010033,biological_process response to organic substance;GO:0010243,biological_process response to organonitrogen compound;GO:0014070,biological_process response to organic cyclic compound;GO:0014732,biological_process skeletal muscle atrophy;GO:0014878,biological_process response to electrical stimulus involved in regulation of muscle adaptation;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0031929,biological_process TOR signaling;GO:0032496,biological_process response to lipopolysaccharide;GO:0032868,biological_process response to insulin;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033574,biological_process response to testosterone;GO:0033762,biological_process response to glucagon;GO:0034612,biological_process response to tumor necrosis factor;GO:0042277,molecular_function peptide binding;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043200,biological_process response to amino acid;GO:0043201,biological_process response to leucine;GO:0043434,biological_process response to peptide hormone;GO:0043491,biological_process protein kinase B signaling;GO:0045202,cellular_component synapse;GO:0045471,biological_process response to ethanol;GO:0045727,biological_process positive regulation of translation;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045948,biological_process positive regulation of translational initiation;GO:0046324,biological_process regulation of glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048633,biological_process positive regulation of skeletal muscle tissue growth;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051384,biological_process response to glucocorticoid;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]; K04688	ribosomal protein S6 kinase B1 [Source:HGNC Symbol%3BAcc:HGNC:10436]
ENSG00000114859	2.55	2.50	3.11	2.92	2.55	3.37	-0.102151582709527	3.01952445886017	0.492675351855231	0.818820178225718	3:184346184-184361651:-	CLCN2	18;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005247,molecular_function voltage-gated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0034707,cellular_component chloride channel complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0060041,biological_process retina development in camera-type eye;GO:0060689,biological_process cell differentiation involved in salivary gland development;GO:1902476,biological_process chloride transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport	CLCN2; chloride channel 2; K05011	chloride voltage-gated channel 2 [Source:HGNC Symbol%3BAcc:HGNC:2020]
ENSG00000100697	7.08	6.41	6.54	6.48	6.04	6.95	0.0547526223014259	5.26655484959441	0.492690559185361	0.818820178225718	14:95086227-95158010:-	DICER1	49;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004386,molecular_function helicase activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0004525,molecular_function ribonuclease III activity;GO:0004530,molecular_function deoxyribonuclease I activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006396,biological_process RNA processing;GO:0010586,biological_process miRNA metabolic process;GO:0010626,biological_process negative regulation of Schwann cell proliferation;GO:0014040,biological_process positive regulation of Schwann cell differentiation;GO:0016787,molecular_function hydrolase activity;GO:0016891,molecular_function endoribonuclease activity, producing 5'-phosphomonoesters;GO:0019904,molecular_function protein domain specific binding;GO:0021675,biological_process nerve development;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0030423,biological_process targeting of mRNA for destruction involved in RNA interference;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0031643,biological_process positive regulation of myelination;GO:0032290,biological_process peripheral nervous system myelin formation;GO:0033167,cellular_component ARC complex;GO:0033168,biological_process conversion of ds siRNA to ss siRNA involved in RNA interference;GO:0035087,biological_process siRNA loading onto RISC involved in RNA interference;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0035197,molecular_function siRNA binding;GO:0035280,biological_process miRNA loading onto RISC involved in gene silencing by miRNA;GO:0036404,biological_process conversion of ds siRNA to ss siRNA;GO:0046872,molecular_function metal ion binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070578,cellular_component RISC-loading complex;GO:0070883,molecular_function pre-miRNA binding;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	DICER1, DCR1; endoribonuclease Dicer [EC:3.1.26.-]; K11592	dicer 1%2C ribonuclease III [Source:HGNC Symbol%3BAcc:HGNC:17098]
ENSG00000137070	3.85	2.64	3.95	4.02	2.99	2.50	0.165402456639308	2.13494961519764	0.492818875491077	0.818923788684168	9:34650701-34661892:+	IL11RA	12;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004896,molecular_function cytokine receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007566,biological_process embryo implantation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032502,biological_process developmental process;GO:0060322,biological_process head development	IL11RA; interleukin 11 receptor alpha; K05056	interleukin 11 receptor subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:5967]
ENSG00000143248	3.64	3.19	3.46	5.11	3.57	3.20	-0.18323195812505	1.37645334606165	0.492907238504336	0.818960989366126	1:163111120-163321791:-	RGS5	8;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity	NA	NA
ENSG00000197140	0.46	0.55	0.42	0.32	0.46	0.43	0.233884820442075	0.370151190664418	0.492986252866307	0.818982649468612	8:39106989-39284911:+	ADAM32	5;GO:0004222,molecular_function metalloendopeptidase activity;GO:0006508,biological_process proteolysis;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ADAM metallopeptidase domain 32 [Source:HGNC Symbol%3BAcc:HGNC:15479]
ENSG00000138326	984.61	988.48	1032.25	1005.91	957.59	984.37	0.0396719321027256	9.77954459724719	0.493259621986853	0.81929270382644	10:78033759-78056812:+	RPS24	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031369,molecular_function translation initiation factor binding;GO:0034101,biological_process erythrocyte homeostasis;GO:0042274,biological_process ribosomal small subunit biogenesis	RP-S24e, RPS24; small subunit ribosomal protein S24e; K02974	ribosomal protein S24 [Source:HGNC Symbol%3BAcc:HGNC:10411]
ENSG00000140990	101.49	103.07	102.75	105.14	107.37	106.69	-0.043470198716987	5.99983094704782	0.493304895544898	0.81929270382644	16:1959507-1961975:+	NDUFB10	11;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain	NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10; K03966	NADH:ubiquinone oxidoreductase subunit B10 [Source:HGNC Symbol%3BAcc:HGNC:7696]
ENSG00000099337	0.98	1.73	1.25	1.12	1.21	0.97	0.240145915431775	0.342224982567894	0.493900628784984	0.820172375265285	19:38319843-38332076:+	KCNK6	18;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0003085,biological_process negative regulation of systemic arterial blood pressure;GO:0005242,molecular_function inward rectifier potassium channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022841,molecular_function potassium ion leak channel activity;GO:0030322,biological_process stabilization of membrane potential;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0060075,biological_process regulation of resting membrane potential;GO:0061337,biological_process cardiac conduction;GO:0071805,biological_process potassium ion transmembrane transport	NA	potassium two pore domain channel subfamily K member 6 [Source:HGNC Symbol%3BAcc:HGNC:6281]
ENSG00000176390	15.26	12.31	11.89	15.16	13.96	12.94	-0.0745033426312668	4.33181938363668	0.494097193646717	0.820357402966084	17:30769387-30824776:-	CRLF3	13;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0042802,molecular_function identical protein binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0071158,biological_process positive regulation of cell cycle arrest	NA	cytokine receptor like factor 3 [Source:HGNC Symbol%3BAcc:HGNC:17177]
ENSG00000114248	0.98	0.63	1.11	1.17	1.33	0.76	-0.212037532973159	0.866497382270481	0.494181887669012	0.820357402966084	3:169839178-169869930:-	LRRC31	NA	NA	leucine rich repeat containing 31 [Source:HGNC Symbol%3BAcc:HGNC:26261]
ENSG00000136213	11.03	11.77	12.03	10.61	10.08	12.51	0.0767693735207543	3.83172791111201	0.494210316553643	0.820357402966084	7:2403559-2448483:+	CHST12	13;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016051,biological_process carbohydrate biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0047756,molecular_function chondroitin 4-sulfotransferase activity;GO:0050656,molecular_function 3'-phosphoadenosine 5'-phosphosulfate binding	CHST12; chondroitin 4-sulfotransferase 12 [EC:2.8.2.5]; K04742	carbohydrate sulfotransferase 12 [Source:HGNC Symbol%3BAcc:HGNC:17423]
ENSG00000108094	30.25	31.58	33.18	31.55	30.74	30.55	0.0450090479328575	6.17948123646073	0.49440967302594	0.820578589553548	10:35008550-35090642:-	CUL2	21;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007050,biological_process cell cycle arrest;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0030163,biological_process protein catabolic process;GO:0030891,cellular_component VCB complex;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0097193,biological_process intrinsic apoptotic signaling pathway	CUL2; cullin 2; K03870	cullin 2 [Source:HGNC Symbol%3BAcc:HGNC:2552]
ENSG00000124177	8.64	9.05	9.26	8.61	8.85	8.89	0.0435320893390883	6.21147976198607	0.494538126007438	0.82068205322598	20:41402100-41618494:-	CHD6	15;GO:0000166,molecular_function nucleotide binding;GO:0001221,molecular_function transcription cofactor binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0036091,biological_process positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	NA	chromodomain helicase DNA binding protein 6 [Source:HGNC Symbol%3BAcc:HGNC:19057]
ENSG00000165115	3.04	2.81	3.00	2.91	2.77	2.82	0.0767990397193423	3.63782462929401	0.494856556278648	0.820857815055817	9:83836697-83921465:-	KIF27	16;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0030030,biological_process cell projection organization;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome	NA	kinesin family member 27 [Source:HGNC Symbol%3BAcc:HGNC:18632]
ENSG00000143409	5.30	4.75	4.76	4.07	5.26	4.63	0.102646976454326	3.08075839884355	0.494966300830805	0.820857815055817	1:150996085-151008375:-	MINDY1	13;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0006508,biological_process proteolysis;GO:0008150,biological_process biological_process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016807,molecular_function cysteine-type carboxypeptidase activity;GO:0036435,molecular_function K48-linked polyubiquitin binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0071108,biological_process protein K48-linked deubiquitination;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	NA	MINDY lysine 48 deubiquitinase 1 [Source:HGNC Symbol%3BAcc:HGNC:25648]
ENSG00000177225	54.26	50.43	51.18	51.73	50.26	50.27	0.047717448860882	5.56660038343216	0.495005661372702	0.820857815055817	11:767219-777488:-	GATD1	4;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome	NA	glutamine amidotransferase like class 1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26616]
ENSG00000170482	6.13	6.03	6.10	5.32	6.73	5.34	0.0847459046164258	3.60806779370486	0.495046684221994	0.820857815055817	5:139367195-139384553:-	SLC23A1	34;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0007420,biological_process brain development;GO:0008520,molecular_function L-ascorbate:sodium symporter activity;GO:0009636,biological_process response to toxic substance;GO:0009925,cellular_component basal plasma membrane;GO:0015081,molecular_function sodium ion transmembrane transporter activity;GO:0015205,molecular_function nucleobase transmembrane transporter activity;GO:0015229,molecular_function L-ascorbic acid transporter activity;GO:0015293,molecular_function symporter activity;GO:0015851,biological_process nucleobase transport;GO:0015882,biological_process L-ascorbic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0030324,biological_process lung development;GO:0033300,molecular_function dehydroascorbic acid transporter activity;GO:0035461,biological_process vitamin transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0043229,cellular_component intracellular organelle;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0070837,biological_process dehydroascorbic acid transport;GO:0070890,molecular_function sodium-dependent L-ascorbate transmembrane transporter activity;GO:0070904,biological_process transepithelial L-ascorbic acid transport;GO:1905039,biological_process carboxylic acid transmembrane transport	SLC23A1, SVCT1; solute carrier family 23 (nucleobase transporter), member 1; K14611	solute carrier family 23 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10974]
ENSG00000130749	7.88	9.51	8.25	8.71	10.24	8.11	-0.0711108124303268	5.10552322933606	0.495055776168469	0.820857815055817	19:47064186-47113752:-	ZC3H4	2;GO:0003723,molecular_function RNA binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 4 [Source:HGNC Symbol%3BAcc:HGNC:17808]
ENSG00000164080	3.80	3.19	3.50	3.90	3.48	3.77	-0.0683638576182798	4.00749288508684	0.49509972880247	0.820857815055817	3:51541143-51668667:+	RAD54L2	7;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0016787,molecular_function hydrolase activity	NA	RAD54 like 2 (S. cerevisiae) [Source:HGNC Symbol%3BAcc:HGNC:29123]
ENSG00000117598	2.86	4.66	4.97	3.50	5.91	4.75	-0.176653395506136	2.14125222426132	0.495147918460388	0.820857815055817	1:98890244-99005032:-	PLPPR5	12;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006644,biological_process phospholipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0042577,molecular_function lipid phosphatase activity;GO:0046839,biological_process phospholipid dephosphorylation;GO:0051491,biological_process positive regulation of filopodium assembly	NA	phospholipid phosphatase related 5 [Source:HGNC Symbol%3BAcc:HGNC:31703]
ENSG00000131013	36.91	35.18	36.63	34.38	38.51	40.68	-0.0503853944373064	5.78579164949614	0.495173070098925	0.820857815055817	6:149504732-149546038:-	PPIL4	10;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0016853,molecular_function isomerase activity;GO:1901407,biological_process regulation of phosphorylation of RNA polymerase II C-terminal domain	NA	peptidylprolyl isomerase like 4 [Source:HGNC Symbol%3BAcc:HGNC:15702]
ENSG00000104331	64.65	72.09	63.61	61.94	68.72	64.31	0.0483613965400328	6.29867470058091	0.495316254778057	0.820985203844318	8:56957932-56993844:-	IMPAD1	25;GO:0001501,biological_process skeletal system development;GO:0001958,biological_process endochondral ossification;GO:0002063,biological_process chondrocyte development;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0005796,cellular_component Golgi lumen;GO:0005829,cellular_component cytosol;GO:0006021,biological_process inositol biosynthetic process;GO:0008254,molecular_function 3'-nucleotidase activity;GO:0008441,molecular_function 3'(2'),5'-bisphosphate nucleotidase activity;GO:0008934,molecular_function inositol monophosphate 1-phosphatase activity;GO:0009791,biological_process post-embryonic development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0030204,biological_process chondroitin sulfate metabolic process;GO:0042733,biological_process embryonic digit morphogenesis;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0052832,molecular_function inositol monophosphate 3-phosphatase activity;GO:0052833,molecular_function inositol monophosphate 4-phosphatase activity;GO:0052834,molecular_function inositol monophosphate phosphatase activity	IMPAD1, IMPA3; inositol monophosphatase 3 [EC:3.1.3.25 3.1.3.7]; K15759	inositol monophosphatase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26019]
ENSG00000103599	1.79	1.17	1.82	1.21	1.62	1.57	0.149156558870466	2.38140065753849	0.49550678670032	0.820985203844318	15:67254799-67502260:+	IQCH	NA	NA	IQ motif containing H [Source:HGNC Symbol%3BAcc:HGNC:25721]
ENSG00000033050	37.48	40.17	40.61	37.10	40.05	38.32	0.045288800945658	6.21533950725555	0.495563875138306	0.820985203844318	7:151207836-151227230:-	ABCF2	9;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0043190,cellular_component ATP-binding cassette (ABC) transporter complex	ABCF2; ATP-binding cassette, subfamily F, member 2; K06185	ATP binding cassette subfamily F member 2 [Source:HGNC Symbol%3BAcc:HGNC:71]
ENSG00000275464	4.71	4.58	3.99	4.59	4.57	4.94	-0.0785092004955522	3.70388409141909	0.495669260263435	0.820985203844318	21:5130870-5154734:-	FP565260.1	5;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030515,molecular_function snoRNA binding;GO:0032040,cellular_component small-subunit processome;GO:0034388,cellular_component Pwp2p-containing subcomplex of 90S preribosome	NA	NA
ENSG00000162510	1.66	0.83	1.63	1.36	1.99	1.51	-0.184567416895743	1.27295417015385	0.495704638259225	0.820985203844318	1:30711276-30723587:-	MATN1	10;GO:0002062,biological_process chondrocyte differentiation;GO:0003429,biological_process growth plate cartilage chondrocyte morphogenesis;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006461,biological_process protein complex assembly;GO:0030198,biological_process extracellular matrix organization;GO:0030500,biological_process regulation of bone mineralization	NA	matrilin 1%2C cartilage matrix protein [Source:HGNC Symbol%3BAcc:HGNC:6907]
ENSG00000066230	15.38	15.97	17.83	17.39	17.04	17.00	-0.0517794654791465	5.39738859908684	0.495782569273476	0.820985203844318	5:473309-524332:-	SLC9A3	25;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0006885,biological_process regulation of pH;GO:0009986,cellular_component cell surface;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015386,molecular_function potassium:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030165,molecular_function PDZ domain binding;GO:0031526,cellular_component brush border membrane;GO:0031982,cellular_component vesicle;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071805,biological_process potassium ion transmembrane transport;GO:0098719,biological_process sodium ion import across plasma membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; K12040	solute carrier family 9 member A3 [Source:HGNC Symbol%3BAcc:HGNC:11073]
ENSG00000150907	1.69	0.78	0.75	1.22	0.66	0.89	0.24701072445514	1.09676691877843	0.495817907174783	0.820985203844318	13:40469952-40666597:-	FOXO1	64;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001223,molecular_function transcription coactivator binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001568,biological_process blood vessel development;GO:0001659,biological_process temperature homeostasis;GO:0001678,biological_process cellular glucose homeostasis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006473,biological_process protein acetylation;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009267,biological_process cellular response to starvation;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010508,biological_process positive regulation of autophagy;GO:0030154,biological_process cell differentiation;GO:0031018,biological_process endocrine pancreas development;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032868,biological_process response to insulin;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032873,biological_process negative regulation of stress-activated MAPK cascade;GO:0034599,biological_process cellular response to oxidative stress;GO:0035947,biological_process regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter;GO:0042127,biological_process regulation of cell proliferation;GO:0042593,biological_process glucose homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045444,biological_process fat cell differentiation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045722,biological_process positive regulation of gluconeogenesis;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070166,biological_process enamel mineralization;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070417,biological_process cellular response to cold;GO:0071455,biological_process cellular response to hyperoxia;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0071732,biological_process cellular response to nitric oxide;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097150,biological_process neuronal stem cell population maintenance;GO:1902617,biological_process response to fluoride;GO:2000177,biological_process regulation of neural precursor cell proliferation;GO:2000377,biological_process regulation of reactive oxygen species metabolic process;GO:2000505,biological_process regulation of energy homeostasis	FOXO1; forkhead box protein O1; K07201	forkhead box O1 [Source:HGNC Symbol%3BAcc:HGNC:3819]
ENSG00000161653	1.91	2.17	2.63	1.80	1.96	2.34	0.148202199528865	1.85710802770579	0.495899752861303	0.820985203844318	17:44004545-44009063:+	NAGS	9;GO:0000050,biological_process urea cycle;GO:0004042,molecular_function acetyl-CoA:L-glutamate N-acetyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006526,biological_process arginine biosynthetic process;GO:0006536,biological_process glutamate metabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0034618,molecular_function arginine binding	NAGS; N-acetylglutamate synthase [EC:2.3.1.1]; K11067	N-acetylglutamate synthase [Source:HGNC Symbol%3BAcc:HGNC:17996]
ENSG00000149927	11.71	9.88	11.10	9.92	9.23	11.95	0.0878777744949291	3.69615510397622	0.495912625059579	0.820985203844318	16:30005508-30023270:-	DOC2A	23;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005764,cellular_component lysosome;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030276,molecular_function clathrin binding;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0070382,cellular_component exocytic vesicle	NA	double C2 domain alpha [Source:HGNC Symbol%3BAcc:HGNC:2985]
ENSG00000189337	19.07	16.65	16.60	17.30	18.39	19.03	-0.0505839167854078	5.7016809161279	0.495925073899678	0.820985203844318	1:13892791-15118043:+	KAZN	12;GO:0001533,cellular_component cornified envelope;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0016607,cellular_component nuclear speck;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0031424,biological_process keratinization;GO:0070268,biological_process cornification	NA	kazrin%2C periplakin interacting protein [Source:HGNC Symbol%3BAcc:HGNC:29173]
ENSG00000171603	100.46	99.46	98.43	102.55	102.05	104.39	-0.0388033775921771	8.22036533415286	0.495977446518049	0.820985203844318	1:9729025-9824526:-	CLSTN1	27;GO:0000139,cellular_component Golgi membrane;GO:0001540,molecular_function beta-amyloid binding;GO:0001558,biological_process regulation of cell growth;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009986,cellular_component cell surface;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019894,molecular_function kinesin binding;GO:0030054,cellular_component cell junction;GO:0042988,molecular_function X11-like protein binding;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0050806,biological_process positive regulation of synaptic transmission;GO:0051965,biological_process positive regulation of synapse assembly;GO:0070062,cellular_component extracellular exosome	NA	calsyntenin 1 [Source:HGNC Symbol%3BAcc:HGNC:17447]
ENSG00000119446	24.78	22.80	22.60	23.91	22.62	28.37	-0.0821636379506915	3.80495305091613	0.49604917568682	0.820994455706733	9:122237623-122264839:-	RBM18	2;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding	NA	RNA binding motif protein 18 [Source:HGNC Symbol%3BAcc:HGNC:28413]
ENSG00000153046	17.19	14.73	17.63	18.34	17.39	16.47	-0.0562682478399608	4.9817322834051	0.496185924078172	0.821066805948883	6:4706158-4955551:+	CDYL	20;GO:0003714,molecular_function transcription corepressor activity;GO:0003824,molecular_function catalytic activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007283,biological_process spermatogenesis;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016573,biological_process histone acetylation;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030674,molecular_function protein binding, bridging;GO:0035064,molecular_function methylated histone binding;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	chromodomain Y like [Source:HGNC Symbol%3BAcc:HGNC:1811]
ENSG00000164746	2.84	2.44	3.39	4.04	2.53	3.31	-0.164200330169271	1.73500992813366	0.496225181521672	0.821066805948883	7:48035510-48061304:+	C7orf57	NA	NA	chromosome 7 open reading frame 57 [Source:HGNC Symbol%3BAcc:HGNC:22247]
ENSG00000236287	36.15	32.18	33.56	35.51	33.78	36.90	-0.0459215390628132	6.17707625538098	0.496299313166032	0.82107591638326	11:10812073-10858796:-	ZBED5	7;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger BED-type containing 5 [Source:HGNC Symbol%3BAcc:HGNC:30803]
ENSG00000135709	4.58	5.65	5.31	5.10	7.38	4.67	-0.13347975231306	2.77583396419172	0.496362980467251	0.82107591638326	16:85027750-85094230:+	KIAA0513	1;GO:0005737,cellular_component cytoplasm	NA	KIAA0513 [Source:HGNC Symbol%3BAcc:HGNC:29058]
ENSG00000161010	109.70	101.46	101.43	99.55	102.00	104.41	0.043349522251235	7.2204942260229	0.496475587378496	0.821117823697377	5:179835132-179862173:-	MRNIP	16;GO:0003674,molecular_function molecular_function;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0008150,biological_process biological_process;GO:0010212,biological_process response to ionizing radiation;GO:0030870,cellular_component Mre11 complex;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0071168,biological_process protein localization to chromatin;GO:1905168,biological_process positive regulation of double-strand break repair via homologous recombination;GO:2001032,biological_process regulation of double-strand break repair via nonhomologous end joining	NA	MRN complex interacting protein [Source:HGNC Symbol%3BAcc:HGNC:30817]
ENSG00000113356	2.17	2.42	2.06	2.10	1.72	1.88	0.224153739493783	0.75301649727534	0.496578408266258	0.821117823697377	5:90471747-90514553:+	POLR3G	15;GO:0000790,cellular_component nuclear chromatin;GO:0002376,biological_process immune system process;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008283,biological_process cell proliferation;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0051607,biological_process defense response to virus	RPC7, POLR3G; DNA-directed RNA polymerase III subunit RPC7; K03024	RNA polymerase III subunit G [Source:HGNC Symbol%3BAcc:HGNC:30075]
ENSG00000112715	624.26	418.20	653.79	700.46	438.19	714.67	-0.115904272131652	9.53751948880051	0.496586764077677	0.821117823697377	6:43770183-43786487:+	VEGFA	117;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001525,biological_process angiogenesis;GO:0001541,biological_process ovarian follicle development;GO:0001569,biological_process patterning of blood vessels;GO:0001570,biological_process vasculogenesis;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001968,molecular_function fibronectin binding;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002092,biological_process positive regulation of receptor internalization;GO:0002576,biological_process platelet degranulation;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0003007,biological_process heart morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003169,biological_process coronary vein morphogenesis;GO:0005125,molecular_function cytokine activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005172,molecular_function vascular endothelial growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007498,biological_process mesoderm development;GO:0007595,biological_process lactation;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0030141,cellular_component secretory granule;GO:0030154,biological_process cell differentiation;GO:0030224,biological_process monocyte differentiation;GO:0030225,biological_process macrophage differentiation;GO:0030324,biological_process lung development;GO:0030335,biological_process positive regulation of cell migration;GO:0030823,biological_process regulation of cGMP metabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031077,biological_process post-embryonic camera-type eye development;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032147,biological_process activation of protein kinase activity;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035148,biological_process tube formation;GO:0035767,biological_process endothelial cell chemotaxis;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0036303,biological_process lymph vessel morphogenesis;GO:0038033,biological_process positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0038091,biological_process positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway;GO:0038190,biological_process VEGF-activated neuropilin signaling pathway;GO:0040007,biological_process growth;GO:0042056,molecular_function chemoattractant activity;GO:0042462,biological_process eye photoreceptor cell development;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043129,biological_process surfactant homeostasis;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043183,molecular_function vascular endothelial growth factor receptor 1 binding;GO:0043184,molecular_function vascular endothelial growth factor receptor 2 binding;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048018,molecular_function receptor agonist activity;GO:0048469,biological_process cell maturation;GO:0048593,biological_process camera-type eye morphogenesis;GO:0048739,biological_process cardiac muscle fiber development;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048842,biological_process positive regulation of axon extension involved in axon guidance;GO:0048844,biological_process artery morphogenesis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050840,molecular_function extracellular matrix binding;GO:0050918,biological_process positive chemotaxis;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0050930,biological_process induction of positive chemotaxis;GO:0051272,biological_process positive regulation of cellular component movement;GO:0051781,biological_process positive regulation of cell division;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0060319,biological_process primitive erythrocyte differentiation;GO:0060749,biological_process mammary gland alveolus development;GO:0060754,biological_process positive regulation of mast cell chemotaxis;GO:0060948,biological_process cardiac vascular smooth muscle cell development;GO:0060982,biological_process coronary artery morphogenesis;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061419,biological_process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0071456,biological_process cellular response to hypoxia;GO:0071542,biological_process dopaminergic neuron differentiation;GO:0071679,biological_process commissural neuron axon guidance;GO:0090037,biological_process positive regulation of protein kinase C signaling;GO:0090050,biological_process positive regulation of cell migration involved in sprouting angiogenesis;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0090259,biological_process regulation of retinal ganglion cell axon guidance;GO:0097475,biological_process motor neuron migration;GO:1900086,biological_process positive regulation of peptidyl-tyrosine autophosphorylation;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1901727,biological_process positive regulation of histone deacetylase activity;GO:1902336,biological_process positive regulation of retinal ganglion cell axon guidance;GO:1903572,biological_process positive regulation of protein kinase D signaling	VEGFA; vascular endothelial growth factor A; K05448	vascular endothelial growth factor A [Source:HGNC Symbol%3BAcc:HGNC:12680]
ENSG00000100084	15.76	15.85	14.77	14.74	15.29	15.22	0.0456407770377284	5.58085641196099	0.49693930988088	0.821529767245622	22:19330697-19447450:-	HIRA	22;GO:0000790,cellular_component nuclear chromatin;GO:0001649,biological_process osteoblast differentiation;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006325,biological_process chromatin organization;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007369,biological_process gastrulation;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016569,biological_process covalent chromatin modification;GO:0016605,cellular_component PML body;GO:0031491,molecular_function nucleosome binding;GO:0031935,biological_process regulation of chromatin silencing;GO:0042692,biological_process muscle cell differentiation;GO:0043234,cellular_component protein complex;GO:0070062,cellular_component extracellular exosome;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	histone cell cycle regulator [Source:HGNC Symbol%3BAcc:HGNC:4916]
ENSG00000122692	45.06	45.76	44.29	47.09	48.00	45.28	-0.0438227545238747	6.14664580783275	0.496968260875483	0.821529767245622	9:33041763-33076659:-	SMU1	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm	NA	DNA replication regulator and spliceosomal factor [Source:HGNC Symbol%3BAcc:HGNC:18247]
ENSG00000182240	67.67	68.20	65.41	66.97	68.33	61.18	0.0464391431031358	6.68938730883721	0.497151209062946	0.821590979998666	21:41167800-41282518:+	BACE2	16;GO:0001540,molecular_function beta-amyloid binding;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0008233,molecular_function peptidase activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016486,biological_process peptide hormone processing;GO:0016787,molecular_function hydrolase activity;GO:0030163,biological_process protein catabolic process;GO:0042985,biological_process negative regulation of amyloid precursor protein biosynthetic process;GO:0050435,biological_process beta-amyloid metabolic process	BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45]; K07747	beta-site APP-cleaving enzyme 2 [Source:HGNC Symbol%3BAcc:HGNC:934]
ENSG00000224531	10.87	12.60	11.59	13.99	12.78	12.36	-0.154588729757537	1.81657584318146	0.497211223194333	0.821590979998666	6:11094032-11138733:+	SMIM13	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 13 [Source:HGNC Symbol%3BAcc:HGNC:27356]
ENSG00000137831	52.99	48.40	51.79	55.35	49.25	54.90	-0.0459592496128768	7.82690222314216	0.49727368395491	0.821590979998666	15:70654553-70763593:-	UACA	11;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome;GO:0097190,biological_process apoptotic signaling pathway;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling	NA	uveal autoantigen with coiled-coil domains and ankyrin repeats [Source:HGNC Symbol%3BAcc:HGNC:15947]
ENSG00000139514	27.70	25.98	28.59	30.04	26.53	29.36	-0.048872205401903	5.73160483795328	0.497317839058485	0.821590979998666	13:29509409-29595688:-	SLC7A1	12;GO:0003333,biological_process amino acid transmembrane transport;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015181,molecular_function arginine transmembrane transporter activity;GO:0015809,biological_process arginine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1903826,biological_process arginine transmembrane transport	SLC7A1, ATRC1; solute carrier family 7 (cationic amino acid transporter), member 1; K13863	solute carrier family 7 member 1 [Source:HGNC Symbol%3BAcc:HGNC:11057]
ENSG00000171824	43.15	42.15	42.00	44.22	44.91	43.04	-0.0420145188514789	6.84605814842509	0.497336230058002	0.821590979998666	1:11066617-11099881:-	EXOSC10	39;GO:0000166,molecular_function nucleotide binding;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004532,molecular_function exoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0009048,biological_process dosage compensation by inactivation of X chromosome;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0035327,cellular_component transcriptionally active chromatin;GO:0044237,biological_process cellular metabolic process;GO:0070034,molecular_function telomerase RNA binding;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071034,biological_process CUT catabolic process;GO:0071035,biological_process nuclear polyadenylation-dependent rRNA catabolic process;GO:0071044,biological_process histone mRNA catabolic process;GO:0071048,biological_process nuclear retention of unspliced pre-mRNA at the site of transcription;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:1904872,biological_process regulation of telomerase RNA localization to Cajal body	RRP6, EXOSC10; exosome complex exonuclease RRP6 [EC:3.1.13.-]; K12591	exosome component 10 [Source:HGNC Symbol%3BAcc:HGNC:9138]
ENSG00000169490	27.13	33.23	25.69	30.47	30.87	29.47	-0.0758576990584564	4.45687146262257	0.49764234018627	0.821925403815965	8:38988807-38996824:-	TM2D2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	TM2 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24127]
ENSG00000132436	6.32	7.18	6.99	8.26	6.00	7.65	-0.0895352105191917	3.85235942550789	0.49767109764608	0.821925403815965	7:50444127-50542535:-	FIGNL1	19;GO:0000166,molecular_function nucleotide binding;GO:0000228,cellular_component nuclear chromosome;GO:0000287,molecular_function magnesium ion binding;GO:0001649,biological_process osteoblast differentiation;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0033687,biological_process osteoblast proliferation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle;GO:0070062,cellular_component extracellular exosome;GO:0071479,biological_process cellular response to ionizing radiation;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	NA	fidgetin like 1 [Source:HGNC Symbol%3BAcc:HGNC:13286]
ENSG00000151092	35.71	31.14	36.00	36.51	34.55	36.30	-0.0467473490268921	6.17836972099475	0.497742295373058	0.821933632096019	3:25718943-25790039:-	NGLY1	11;GO:0000224,molecular_function peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0006516,biological_process glycoprotein catabolic process;GO:0006517,biological_process protein deglycosylation;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	E3.5.1.52, NGLY1, PNG1; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:3.5.1.52]; K01456	N-glycanase 1 [Source:HGNC Symbol%3BAcc:HGNC:17646]
ENSG00000075234	8.63	10.61	10.02	9.15	10.46	8.26	0.0775460072472567	4.03433606935693	0.497834689294708	0.821976855309285	22:46267960-46294008:+	TTC38	1;GO:0070062,cellular_component extracellular exosome	NA	tetratricopeptide repeat domain 38 [Source:HGNC Symbol%3BAcc:HGNC:26082]
ENSG00000168610	60.90	57.60	63.62	59.26	59.17	59.84	0.0437691389607685	7.12307781687708	0.497943954168047	0.822047919016886	17:42313323-42388568:-	STAT3	102;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001659,biological_process temperature homeostasis;GO:0001754,biological_process eye photoreceptor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006606,biological_process protein import into nucleus;GO:0006928,biological_process movement of cell or subcellular component;GO:0006953,biological_process acute-phase response;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007259,biological_process JAK-STAT cascade;GO:0007399,biological_process nervous system development;GO:0007568,biological_process aging;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010033,biological_process response to organic substance;GO:0010628,biological_process positive regulation of gene expression;GO:0010730,biological_process negative regulation of hydrogen peroxide biosynthetic process;GO:0014070,biological_process response to organic cyclic compound;GO:0016032,biological_process viral process;GO:0016310,biological_process phosphorylation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019827,biological_process stem cell population maintenance;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0019953,biological_process sexual reproduction;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0031490,molecular_function chromatin DNA binding;GO:0031730,molecular_function CCR5 chemokine receptor binding;GO:0032355,biological_process response to estradiol;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033210,biological_process leptin-mediated signaling pathway;GO:0034097,biological_process response to cytokine;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042493,biological_process response to drug;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042593,biological_process glucose homeostasis;GO:0042755,biological_process eating behavior;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043434,biological_process response to peptide hormone;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044320,biological_process cellular response to leptin stimulus;GO:0044321,biological_process response to leptin;GO:0045471,biological_process response to ethanol;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0045820,biological_process negative regulation of glycolytic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0046983,molecular_function protein dimerization activity;GO:0048708,biological_process astrocyte differentiation;GO:0051726,biological_process regulation of cell cycle;GO:0060019,biological_process radial glial cell differentiation;GO:0060259,biological_process regulation of feeding behavior;GO:0060396,biological_process growth hormone receptor signaling pathway;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway;GO:0060548,biological_process negative regulation of cell death;GO:0070102,biological_process interleukin-6-mediated signaling pathway;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0072540,biological_process T-helper 17 cell lineage commitment;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:0097009,biological_process energy homeostasis;GO:1901215,biological_process negative regulation of neuron death;GO:1902728,biological_process positive regulation of growth factor dependent skeletal muscle satellite cell proliferation;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1904685,biological_process positive regulation of metalloendopeptidase activity;GO:2000637,biological_process positive regulation of gene silencing by miRNA;GO:2000737,biological_process negative regulation of stem cell differentiation;GO:2001171,biological_process positive regulation of ATP biosynthetic process;GO:2001223,biological_process negative regulation of neuron migration	STAT3; signal transducer and activator of transcription 3; K04692	signal transducer and activator of transcription 3 [Source:HGNC Symbol%3BAcc:HGNC:11364]
ENSG00000180592	1.11	1.23	1.19	0.80	1.25	1.14	0.154332892973408	1.67501755357597	0.498193620153189	0.822350719010842	10:21513477-21526368:-	SKIDA1	NA	NA	SKI/DACH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:32697]
ENSG00000164032	799.32	857.85	691.74	777.58	891.15	793.83	-0.0569419189812908	8.26767287712248	0.498305075270858	0.82236495997055	4:99948085-99950388:-	H2AFZ	17;GO:0000786,cellular_component nucleosome;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005719,cellular_component nuclear euchromatin;GO:0005720,cellular_component nuclear heterochromatin;GO:0006342,biological_process chromatin silencing;GO:0031490,molecular_function chromatin DNA binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome;GO:0071392,biological_process cellular response to estradiol stimulus	NA	H2A histone family member Z [Source:HGNC Symbol%3BAcc:HGNC:4741]
ENSG00000197381	5.17	4.75	4.75	5.14	5.05	5.41	-0.0740029267050716	3.63847630311806	0.498334748159065	0.82236495997055	21:45073852-45226560:+	ADARB1	32;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003726,molecular_function double-stranded RNA adenosine deaminase activity;GO:0003729,molecular_function mRNA binding;GO:0004000,molecular_function adenosine deaminase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006382,biological_process adenosine to inosine editing;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016787,molecular_function hydrolase activity;GO:0021610,biological_process facial nerve morphogenesis;GO:0021618,biological_process hypoglossal nerve morphogenesis;GO:0021965,biological_process spinal cord ventral commissure morphogenesis;GO:0030336,biological_process negative regulation of cell migration;GO:0035264,biological_process multicellular organism growth;GO:0044387,biological_process negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050884,biological_process neuromuscular process controlling posture;GO:0051607,biological_process defense response to virus;GO:0051726,biological_process regulation of cell cycle;GO:0060384,biological_process innervation;GO:0060415,biological_process muscle tissue morphogenesis;GO:0061744,biological_process motor behavior;GO:0097049,biological_process motor neuron apoptotic process	NA	adenosine deaminase%2C RNA specific B1 [Source:HGNC Symbol%3BAcc:HGNC:226]
ENSG00000198960	22.29	24.63	25.60	23.54	24.69	21.56	0.0659292182609945	4.42481705520349	0.498464523532731	0.822380234089345	X:101615117-101618001:-	ARMCX6	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	armadillo repeat containing%2C X-linked 6 [Source:HGNC Symbol%3BAcc:HGNC:26094]
ENSG00000047849	65.99	65.94	63.37	64.09	64.19	63.42	0.03849965956377	9.10174540128678	0.498559097939044	0.822380234089345	3:47850689-48089272:-	MAP4	20;GO:0003723,molecular_function RNA binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005930,cellular_component axoneme;GO:0007052,biological_process mitotic spindle organization;GO:0008017,molecular_function microtubule binding;GO:0014069,cellular_component postsynaptic density;GO:0015631,molecular_function tubulin binding;GO:0031175,biological_process neuron projection development;GO:0043005,cellular_component neuron projection;GO:0051012,biological_process microtubule sliding;GO:0051294,biological_process establishment of spindle orientation;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0072686,cellular_component mitotic spindle;GO:1902856,biological_process negative regulation of nonmotile primary cilium assembly	NA	microtubule associated protein 4 [Source:HGNC Symbol%3BAcc:HGNC:6862]
ENSG00000124422	57.03	57.53	54.83	57.71	60.15	58.00	-0.0428172028326232	6.85990043052349	0.498570025246866	0.822380234089345	17:20999592-21043760:-	USP22	29;GO:0000124,cellular_component SAGA complex;GO:0003713,molecular_function transcription coactivator activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009790,biological_process embryo development;GO:0010485,molecular_function H4 histone acetyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016574,biological_process histone ubiquitination;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043967,biological_process histone H4 acetylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046872,molecular_function metal ion binding;GO:0070461,cellular_component SAGA-type complex	NA	ubiquitin specific peptidase 22 [Source:HGNC Symbol%3BAcc:HGNC:12621]
ENSG00000122687	29.66	30.22	32.07	33.60	30.56	32.39	-0.0583873827392137	4.59217190922593	0.498615124173125	0.822380234089345	7:2234230-2242198:-	MRM2	12;GO:0000451,biological_process rRNA 2'-O-methylation;GO:0001510,biological_process RNA methylation;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008283,biological_process cell proliferation;GO:0008650,molecular_function rRNA (uridine-2'-O-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation	NA	mitochondrial rRNA methyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:16352]
ENSG00000144228	6.75	6.42	8.37	7.87	6.71	8.72	-0.0968893942520674	3.2723026485817	0.498675261579835	0.822380234089345	2:138501800-138573547:+	SPOPL	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	SPOP; speckle-type POZ protein; K10523	speckle type BTB/POZ protein like [Source:HGNC Symbol%3BAcc:HGNC:27934]
ENSG00000085978	20.98	18.12	20.17	22.68	19.28	20.32	-0.0552213259776167	5.25423792237037	0.498860445664275	0.82250385984117	2:233210050-233295674:+	ATG16L1	21;GO:0000045,biological_process autophagosome assembly;GO:0000421,cellular_component autophagosome membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0039689,biological_process negative stranded viral RNA replication;GO:0042802,molecular_function identical protein binding;GO:0051020,molecular_function GTPase binding;GO:0051260,biological_process protein homooligomerization;GO:0061739,biological_process protein lipidation involved in autophagosome assembly;GO:0098792,biological_process xenophagy	NA	autophagy related 16 like 1 [Source:HGNC Symbol%3BAcc:HGNC:21498]
ENSG00000121039	13.39	15.97	16.84	13.17	16.09	14.78	0.0774427309108965	3.9554307080439	0.49891815845261	0.82250385984117	8:73294611-73325281:+	RDH10	30;GO:0001523,biological_process retinoid metabolic process;GO:0001656,biological_process metanephros development;GO:0001701,biological_process in utero embryonic development;GO:0002138,biological_process retinoic acid biosynthetic process;GO:0004745,molecular_function retinol dehydrogenase activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007601,biological_process visual perception;GO:0008406,biological_process gonad development;GO:0009887,biological_process organ morphogenesis;GO:0014032,biological_process neural crest cell development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031076,biological_process embryonic camera-type eye development;GO:0031090,cellular_component organelle membrane;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0042572,biological_process retinol metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043583,biological_process ear development;GO:0043584,biological_process nose development;GO:0044297,cellular_component cell body;GO:0048568,biological_process embryonic organ development;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0052650,molecular_function NADP-retinol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060431,biological_process primary lung bud formation;GO:0060449,biological_process bud elongation involved in lung branching	RDH10; retinol dehydrogenase 10 [EC:1.1.1.-]; K11151	retinol dehydrogenase 10 [Source:HGNC Symbol%3BAcc:HGNC:19975]
ENSG00000179988	4.03	3.00	3.08	3.37	4.27	3.56	-0.122630448595704	2.19986997887014	0.498972535562559	0.82250385984117	10:122954380-122997513:+	PSTK	10;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0001514,biological_process selenocysteine incorporation;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0097056,biological_process selenocysteinyl-tRNA(Sec) biosynthetic process	PSTK; O-phosphoseryl-tRNA(Sec) kinase [EC:2.7.1.164]; K10837	phosphoseryl-tRNA kinase [Source:HGNC Symbol%3BAcc:HGNC:28578]
ENSG00000115875	111.35	105.02	114.26	104.41	108.05	110.95	0.0451686062167242	6.50162609057102	0.499054108317839	0.82250385984117	2:38743598-38751494:-	SRSF7	21;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006810,biological_process transport;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0019904,molecular_function protein domain specific binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0046872,molecular_function metal ion binding;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0051028,biological_process mRNA transport;GO:0070062,cellular_component extracellular exosome;GO:1990830,biological_process cellular response to leukemia inhibitory factor	SFRS7; splicing factor, arginine/serine-rich 7; K12896	serine and arginine rich splicing factor 7 [Source:HGNC Symbol%3BAcc:HGNC:10789]
ENSG00000140479	0.33	0.39	0.35	0.24	0.22	0.43	0.239395477479034	0.34114816730834	0.499197495148114	0.82250385984117	15:101297141-101525202:-	PCSK6	28;GO:0004175,molecular_function endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007354,biological_process zygotic determination of anterior/posterior axis, embryo;GO:0007368,biological_process determination of left/right symmetry;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009100,biological_process glycoprotein metabolic process;GO:0009986,cellular_component cell surface;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016485,biological_process protein processing;GO:0016486,biological_process peptide hormone processing;GO:0016787,molecular_function hydrolase activity;GO:0030510,biological_process regulation of BMP signaling pathway;GO:0031012,cellular_component extracellular matrix;GO:0032455,biological_process nerve growth factor processing;GO:0032902,biological_process nerve growth factor production;GO:0032940,biological_process secretion by cell;GO:0048406,molecular_function nerve growth factor binding;GO:0051004,biological_process regulation of lipoprotein lipase activity;GO:0070268,biological_process cornification	NA	proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol%3BAcc:HGNC:8569]
ENSG00000137098	0.99	1.01	0.95	1.09	0.84	1.44	-0.195028700366542	0.972799375233818	0.499312603496888	0.82250385984117	9:35808044-35812272:-	SPAG8	17;GO:0001669,cellular_component acrosomal vesicle;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0008017,molecular_function microtubule binding;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032092,biological_process positive regulation of protein binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	sperm associated antigen 8 [Source:HGNC Symbol%3BAcc:HGNC:14105]
ENSG00000100342	519.01	449.47	509.20	535.53	477.21	528.40	-0.0486991382945841	9.58016587851426	0.499326710665014	0.82250385984117	22:36253009-36267530:+	APOL1	23;GO:0005254,molecular_function chloride channel activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008289,molecular_function lipid binding;GO:0019835,biological_process cytolysis;GO:0031224,cellular_component intrinsic component of membrane;GO:0031640,biological_process killing of cells of other organism;GO:0034361,cellular_component very-low-density lipoprotein particle;GO:0034364,cellular_component high-density lipoprotein particle;GO:0042157,biological_process lipoprotein metabolic process;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045087,biological_process innate immune response;GO:0072562,cellular_component blood microparticle;GO:1902476,biological_process chloride transmembrane transport	NA	apolipoprotein L1 [Source:HGNC Symbol%3BAcc:HGNC:618]
ENSG00000204564	7.95	7.96	7.26	7.48	7.12	7.54	0.0733551258045553	3.52126973532937	0.499391709098018	0.82250385984117	6:30647038-30653210:+	C6orf136	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 6 open reading frame 136 [Source:HGNC Symbol%3BAcc:HGNC:21301]
ENSG00000149346	1.86	0.96	1.60	1.86	1.41	1.91	-0.182211925065739	1.17111773911253	0.499436709317408	0.82250385984117	20:10435302-10636829:+	SLX4IP	1;GO:0005515,molecular_function protein binding	NA	SLX4 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:16225]
ENSG00000127580	7.24	7.48	8.27	7.35	6.84	7.95	0.0652586527913149	4.38769322277778	0.499474243869631	0.82250385984117	16:684621-690444:-	WDR24	9;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006914,biological_process autophagy;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0032008,biological_process positive regulation of TOR signaling;GO:0034198,biological_process cellular response to amino acid starvation;GO:0061700,cellular_component GATOR2 complex	NA	WD repeat domain 24 [Source:HGNC Symbol%3BAcc:HGNC:20852]
ENSG00000163848	17.06	16.16	16.98	17.58	17.68	17.07	-0.0456930730988017	5.3585916290836	0.499479102189861	0.82250385984117	3:125225560-125375354:-	ZNF148	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006968,biological_process cellular defense response;GO:0007276,biological_process gamete generation;GO:0010629,biological_process negative regulation of gene expression;GO:0021762,biological_process substantia nigra development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 148 [Source:HGNC Symbol%3BAcc:HGNC:12933]
ENSG00000133059	4.68	4.62	4.59	3.99	4.39	4.91	0.0746427386136302	3.70114693004735	0.499577750496048	0.822557184892883	1:205142504-205211566:-	DSTYK	23;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030054,cellular_component cell junction;GO:0033674,biological_process positive regulation of kinase activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045743,biological_process positive regulation of fibroblast growth factor receptor signaling pathway;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade	NA	dual serine/threonine and tyrosine protein kinase [Source:HGNC Symbol%3BAcc:HGNC:29043]
ENSG00000198492	48.18	49.35	51.99	50.47	53.18	51.78	-0.0439359152555223	6.46766140322416	0.499738253285259	0.822698353300191	1:28736620-28769775:+	YTHDF2	12;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006959,biological_process humoral immune response;GO:0043488,biological_process regulation of mRNA stability;GO:0048598,biological_process embryonic morphogenesis;GO:0061157,biological_process mRNA destabilization;GO:1903679,biological_process positive regulation of cap-independent translational initiation;GO:1990247,molecular_function N6-methyladenosine-containing RNA binding	NA	YTH N6-methyladenosine RNA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:31675]
ENSG00000228439	22.51	23.10	25.48	26.12	22.09	28.40	-0.0973422345602114	3.19189864394868	0.49996904100789	0.822698353300191	6:99520692-99531918:+	TSTD3	NA	NA	thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:40910]
ENSG00000118402	0.75	1.42	1.64	1.11	0.89	1.19	0.243029208912947	0.312490113021124	0.500047899289969	0.822698353300191	6:79914811-79947580:-	ELOVL4	21;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0008020,molecular_function G-protein coupled photoreceptor activity;GO:0009584,biological_process detection of visible light;GO:0009922,molecular_function fatty acid elongase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0019367,biological_process fatty acid elongation, saturated fatty acid;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034625,biological_process fatty acid elongation, monounsaturated fatty acid;GO:0034626,biological_process fatty acid elongation, polyunsaturated fatty acid;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0102336,molecular_function 3-oxo-arachidoyl-CoA synthase activity;GO:0102337,molecular_function 3-oxo-cerotoyl-CoA synthase activity;GO:0102338,molecular_function 3-oxo-lignoceronyl-CoA synthase activity	ELOVL4; elongation of very long chain fatty acids protein 4 [EC:2.3.1.199]; K10249	ELOVL fatty acid elongase 4 [Source:HGNC Symbol%3BAcc:HGNC:14415]
ENSG00000128829	17.50	17.40	17.03	17.15	16.07	17.56	0.0434680560571544	6.43012128476005	0.500099412016504	0.822698353300191	15:39934145-40035591:+	EIF2AK4	48;GO:0000049,molecular_function tRNA binding;GO:0000077,biological_process DNA damage checkpoint;GO:0000166,molecular_function nucleotide binding;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002250,biological_process adaptive immune response;GO:0002286,biological_process T cell activation involved in immune response;GO:0002376,biological_process immune system process;GO:0002821,biological_process positive regulation of adaptive immune response;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004694,molecular_function eukaryotic translation initiation factor 2alpha kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007399,biological_process nervous system development;GO:0007612,biological_process learning;GO:0007616,biological_process long-term memory;GO:0010998,biological_process regulation of translational initiation by eIF2 alpha phosphorylation;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019081,biological_process viral translation;GO:0022626,cellular_component cytosolic ribosome;GO:0032057,biological_process negative regulation of translational initiation in response to stress;GO:0032792,biological_process negative regulation of CREB transcription factor activity;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034644,biological_process cellular response to UV;GO:0036492,biological_process eiF2alpha phosphorylation in response to endoplasmic reticulum stress;GO:0039520,biological_process induction by virus of host autophagy;GO:0044828,biological_process negative regulation by host of viral genome replication;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045947,biological_process negative regulation of translational initiation;GO:0046777,biological_process protein autophosphorylation;GO:0051607,biological_process defense response to virus;GO:0060259,biological_process regulation of feeding behavior;GO:0060733,biological_process regulation of eIF2 alpha phosphorylation by amino acid starvation;GO:0070417,biological_process cellular response to cold;GO:0071264,biological_process positive regulation of translational initiation in response to starvation;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1990138,biological_process neuron projection extension;GO:1990253,biological_process cellular response to leucine starvation	EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]; K16196	eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:19687]
ENSG00000155330	10.64	10.94	9.98	10.71	10.85	12.39	-0.100279244319152	2.88919398532484	0.500142571542871	0.822698353300191	16:46796606-46831411:-	C16orf87	1;GO:0005515,molecular_function protein binding	NA	chromosome 16 open reading frame 87 [Source:HGNC Symbol%3BAcc:HGNC:33754]
ENSG00000112305	14.07	13.84	12.92	14.16	14.70	13.96	-0.0578666704976793	4.57005043901285	0.500182354923116	0.822698353300191	6:70667775-70862015:+	SMAP1	9;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030276,molecular_function clathrin binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:2000369,biological_process regulation of clathrin-mediated endocytosis	SMAP; stromal membrane-associated protein; K12486	small ArfGAP 1 [Source:HGNC Symbol%3BAcc:HGNC:19651]
ENSG00000143382	1.39	1.36	1.49	1.34	1.69	1.63	-0.122127297804528	2.36547748428373	0.500216072672187	0.822698353300191	1:150549368-150560937:+	ADAMTSL4	15;GO:0002020,molecular_function protease binding;GO:0002064,biological_process epithelial cell development;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005614,cellular_component interstitial matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0008233,molecular_function peptidase activity;GO:0030198,biological_process extracellular matrix organization;GO:0036066,biological_process protein O-linked fucosylation;GO:0043065,biological_process positive regulation of apoptotic process	NA	ADAMTS like 4 [Source:HGNC Symbol%3BAcc:HGNC:19706]
ENSG00000161179	19.79	17.85	19.04	20.03	20.07	19.63	-0.0582037293176065	4.33216826405782	0.500246007955956	0.822698353300191	22:21628088-21630064:-	YDJC	5;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0005975,biological_process carbohydrate metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	YdjC chitooligosaccharide deacetylase homolog [Source:HGNC Symbol%3BAcc:HGNC:27158]
ENSG00000127554	15.34	17.38	14.74	16.15	16.48	17.88	-0.0884851256363104	3.42430292939517	0.500501878290658	0.822698353300191	16:1984206-1987749:+	GFER	14;GO:0001889,biological_process liver development;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0008083,molecular_function growth factor activity;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016971,molecular_function flavin-linked sulfhydryl oxidase activity;GO:0016972,molecular_function thiol oxidase activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	growth factor%2C augmenter of liver regeneration [Source:HGNC Symbol%3BAcc:HGNC:4236]
ENSG00000010017	21.06	22.85	24.53	25.74	22.99	22.89	-0.054273186923909	5.67910717358308	0.500508718300748	0.822698353300191	6:13621497-13711564:-	RANBP9	16;GO:0000165,biological_process MAPK cascade;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0007020,biological_process microtubule nucleation;GO:0007411,biological_process axon guidance;GO:0008536,molecular_function Ran GTPase binding;GO:0016020,cellular_component membrane;GO:0019899,molecular_function enzyme binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	NA	RAN binding protein 9 [Source:HGNC Symbol%3BAcc:HGNC:13727]
ENSG00000197321	26.20	22.58	25.92	25.99	24.80	27.12	-0.0473488685160528	7.41385994303239	0.500510091112103	0.822698353300191	10:29457337-29736781:-	SVIL	22;GO:0002102,cellular_component podosome;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007010,biological_process cytoskeleton organization;GO:0007519,biological_process skeletal muscle tissue development;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030496,cellular_component midbody;GO:0032154,cellular_component cleavage furrow;GO:0032467,biological_process positive regulation of cytokinesis;GO:0036449,cellular_component microtubule minus-end;GO:0042995,cellular_component cell projection;GO:0043034,cellular_component costamere;GO:0051015,molecular_function actin filament binding;GO:0071437,cellular_component invadopodium	NA	supervillin [Source:HGNC Symbol%3BAcc:HGNC:11480]
ENSG00000148343	5.07	5.27	4.97	4.52	4.98	5.08	0.0780565944108165	3.40877715907181	0.50052764814316	0.822698353300191	9:129036620-129072082:+	MIGA2	10;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0008053,biological_process mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0060348,biological_process bone development	NA	mitoguardin 2 [Source:HGNC Symbol%3BAcc:HGNC:23621]
ENSG00000091157	2.13	2.90	2.84	2.54	2.35	2.52	0.0878366085396647	3.54561742606758	0.500620654850332	0.822698353300191	18:56651342-57036606:+	WDR7	4;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0008021,cellular_component synaptic vesicle	NA	WD repeat domain 7 [Source:HGNC Symbol%3BAcc:HGNC:13490]
ENSG00000126945	70.84	80.24	66.66	62.92	79.67	67.55	0.0614159031670293	6.58728983093669	0.500657293958942	0.822698353300191	X:101408294-101414133:+	HNRNPH2	10;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	heterogeneous nuclear ribonucleoprotein H2 [Source:HGNC Symbol%3BAcc:HGNC:5042]
ENSG00000162520	20.19	22.88	19.23	23.14	22.98	19.44	-0.0662936081327389	5.01068010126191	0.500711620217062	0.822698353300191	1:32680359-32703596:-	SYNC	9;GO:0005198,molecular_function structural molecule activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0030018,cellular_component Z disc;GO:0031594,cellular_component neuromuscular junction;GO:0042383,cellular_component sarcolemma;GO:0045103,biological_process intermediate filament-based process;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	syncoilin%2C intermediate filament protein [Source:HGNC Symbol%3BAcc:HGNC:28897]
ENSG00000164048	9.24	6.54	8.21	8.02	9.59	8.36	-0.0885571433587095	3.51401491566975	0.500723923240389	0.822698353300191	3:48241099-48299253:+	ZNF589	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 589 [Source:HGNC Symbol%3BAcc:HGNC:16747]
ENSG00000105649	1.39	2.75	1.34	1.47	2.41	2.56	-0.274556150059032	0.531022831012996	0.500838379094173	0.822777501283215	19:18196783-18204074:-	RAB3A	54;GO:0000166,molecular_function nucleotide binding;GO:0001669,cellular_component acrosomal vesicle;GO:0001671,molecular_function ATPase activator activity;GO:0003016,biological_process respiratory system process;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0007005,biological_process mitochondrion organization;GO:0007269,biological_process neurotransmitter secretion;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0007409,biological_process axonogenesis;GO:0008021,cellular_component synaptic vesicle;GO:0008022,molecular_function protein C-terminus binding;GO:0009791,biological_process post-embryonic development;GO:0014047,biological_process glutamate secretion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016188,biological_process synaptic vesicle maturation;GO:0017157,biological_process regulation of exocytosis;GO:0030324,biological_process lung development;GO:0030424,cellular_component axon;GO:0030667,cellular_component secretory granule membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031489,molecular_function myosin V binding;GO:0031630,biological_process regulation of synaptic vesicle fusion to presynaptic membrane;GO:0032781,biological_process positive regulation of ATPase activity;GO:0036465,biological_process synaptic vesicle recycling;GO:0043195,cellular_component terminal bouton;GO:0043229,cellular_component intracellular organelle;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0045054,biological_process constitutive secretory pathway;GO:0045921,biological_process positive regulation of exocytosis;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:0048790,biological_process maintenance of presynaptic active zone structure;GO:0050975,biological_process sensory perception of touch;GO:0051117,molecular_function ATPase binding;GO:0051602,biological_process response to electrical stimulus;GO:0060201,cellular_component clathrin-sculpted acetylcholine transport vesicle membrane;GO:0060203,cellular_component clathrin-sculpted glutamate transport vesicle membrane;GO:0061024,biological_process membrane organization;GO:0061202,cellular_component clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0061670,biological_process evoked neurotransmitter secretion;GO:0070083,cellular_component clathrin-sculpted monoamine transport vesicle membrane;GO:0098993,cellular_component anchored component of synaptic vesicle membrane;GO:1903307,biological_process positive regulation of regulated secretory pathway;GO:1903561,cellular_component extracellular vesicle	RAB3A; Ras-related protein Rab-3A; K07882	RAB3A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9777]
ENSG00000163468	118.11	129.79	110.33	120.15	130.04	123.18	-0.0489324894900261	7.88587087716055	0.500943105955375	0.822788307145019	1:156308967-156367873:-	CCT3	26;GO:0000166,molecular_function nucleotide binding;GO:0002199,cellular_component zona pellucida receptor complex;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0043209,cellular_component myelin sheath;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044297,cellular_component cell body;GO:0046931,biological_process pore complex assembly;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:1901998,biological_process toxin transport;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	chaperonin containing TCP1 subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:1616]
ENSG00000147654	46.41	44.59	47.91	45.87	50.03	49.17	-0.0484377856992506	5.26494397637664	0.500977525610413	0.822788307145019	8:109539710-109565996:+	EBAG9	8;GO:0000139,cellular_component Golgi membrane;GO:0001558,biological_process regulation of cell growth;GO:0005794,cellular_component Golgi apparatus;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016505,molecular_function peptidase activator activity involved in apoptotic process;GO:0030141,cellular_component secretory granule	NA	estrogen receptor binding site associated%2C antigen%2C 9 [Source:HGNC Symbol%3BAcc:HGNC:3123]
ENSG00000072786	15.95	14.66	16.31	16.27	12.11	16.70	0.0706336571917042	5.54237699394412	0.501332899267058	0.823238866070878	5:172042072-172188386:-	STK10	26;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0035579,cellular_component specific granule membrane;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0046777,biological_process protein autophosphorylation;GO:0070062,cellular_component extracellular exosome;GO:0071593,biological_process lymphocyte aggregation;GO:2000401,biological_process regulation of lymphocyte migration	STK10, LOK; serine/threonine kinase 10 [EC:2.7.11.1]; K08837	serine/threonine kinase 10 [Source:HGNC Symbol%3BAcc:HGNC:11388]
ENSG00000198455	2.84	2.46	3.06	2.30	2.68	2.89	0.107592611802808	2.74304793191464	0.501502362507096	0.823238866070878	X:57591651-57597545:+	ZXDB	7;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger%2C X-linked%2C duplicated B [Source:HGNC Symbol%3BAcc:HGNC:13199]
ENSG00000189306	32.72	35.40	32.59	37.27	33.25	34.78	-0.0567534012309032	4.99727806434581	0.501528318079827	0.823238866070878	22:42509967-42519802:-	RRP7A	10;GO:0000028,biological_process ribosomal small subunit assembly;GO:0001825,biological_process blastocyst formation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0032545,cellular_component CURI complex;GO:0034456,cellular_component UTP-C complex	RRP7; ribosomal RNA-processing protein 7; K14545	ribosomal RNA processing 7 homolog A [Source:HGNC Symbol%3BAcc:HGNC:24286]
ENSG00000123562	325.66	362.24	309.57	301.13	358.41	308.37	0.0546202403412084	8.14599987169825	0.501562536433485	0.823238866070878	X:103675495-103688158:-	MORF4L2	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006342,biological_process chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051155,biological_process positive regulation of striated muscle cell differentiation	NA	mortality factor 4 like 2 [Source:HGNC Symbol%3BAcc:HGNC:16849]
ENSG00000156103	2.69	3.38	3.15	2.53	3.33	2.68	0.114879021163998	2.51612342852877	0.501583464440027	0.823238866070878	8:88032008-88328025:-	MMP16	29;GO:0001503,biological_process ossification;GO:0001958,biological_process endochondral ossification;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0008047,molecular_function enzyme activator activity;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0019538,biological_process protein metabolic process;GO:0022617,biological_process extracellular matrix disassembly;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035988,biological_process chondrocyte proliferation;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046872,molecular_function metal ion binding;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0060348,biological_process bone development;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0097094,biological_process craniofacial suture morphogenesis	MMP16; matrix metalloproteinase-16 (membrane-inserted) [EC:3.4.24.-]; K07996	matrix metallopeptidase 16 [Source:HGNC Symbol%3BAcc:HGNC:7162]
ENSG00000163902	182.34	202.91	184.83	183.63	191.52	182.42	0.0431954313884206	8.4492510023084	0.502311256595128	0.824251140796868	3:128619969-128681075:-	RPN1	17;GO:0003723,molecular_function RNA binding;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0031012,cellular_component extracellular matrix;GO:0042470,cellular_component melanosome	OST1, RPN1; oligosaccharyltransferase complex subunit alpha (ribophorin I); K12666	ribophorin I [Source:HGNC Symbol%3BAcc:HGNC:10381]
ENSG00000163344	51.50	56.91	53.92	51.47	53.46	52.62	0.0504556962072877	4.94646874389376	0.502399061894969	0.824251140796868	1:154924733-154936991:-	PMVK	21;GO:0000166,molecular_function nucleotide binding;GO:0004631,molecular_function phosphomevalonate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019287,biological_process isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0070062,cellular_component extracellular exosome;GO:0070723,biological_process response to cholesterol	PMVK; phosphomevalonate kinase [EC:2.7.4.2]; K13273	phosphomevalonate kinase [Source:HGNC Symbol%3BAcc:HGNC:9141]
ENSG00000092295	0.46	0.47	0.27	0.31	0.62	0.54	-0.294499371066893	0.311933270156877	0.502442373159049	0.824251140796868	14:24249113-24264432:-	TGM1	19;GO:0001533,cellular_component cornified envelope;GO:0003810,molecular_function protein-glutamine gamma-glutamyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006464,biological_process cellular protein modification process;GO:0010838,biological_process positive regulation of keratinocyte proliferation;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018149,biological_process peptide cross-linking;GO:0030216,biological_process keratinocyte differentiation;GO:0031224,cellular_component intrinsic component of membrane;GO:0031424,biological_process keratinization;GO:0043163,biological_process cell envelope organization;GO:0045787,biological_process positive regulation of cell cycle;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification	NA	transglutaminase 1 [Source:HGNC Symbol%3BAcc:HGNC:11777]
ENSG00000106992	22.37	23.43	23.42	20.01	25.28	21.02	0.0736152053048527	4.04751074226716	0.502465832789004	0.824251140796868	9:127866479-127877743:-	AK1	23;GO:0000166,molecular_function nucleotide binding;GO:0001520,cellular_component outer dense fiber;GO:0004017,molecular_function adenylate kinase activity;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006172,biological_process ADP biosynthetic process;GO:0007050,biological_process cell cycle arrest;GO:0009142,biological_process nucleoside triphosphate biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0036126,cellular_component sperm flagellum;GO:0046033,biological_process AMP metabolic process;GO:0046034,biological_process ATP metabolic process;GO:0046939,biological_process nucleotide phosphorylation;GO:0070062,cellular_component extracellular exosome	adk, AK; adenylate kinase [EC:2.7.4.3]; K00939	adenylate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:361]
ENSG00000099977	84.44	96.46	81.32	82.14	93.29	78.24	0.0565042573453103	5.78193013112016	0.5025379076216	0.824260444940132	22:23971364-23980469:-	DDT	6;GO:0004167,molecular_function dopachrome isomerase activity;GO:0005737,cellular_component cytoplasm;GO:0016829,molecular_function lyase activity;GO:0033981,molecular_function D-dopachrome decarboxylase activity;GO:0042438,biological_process melanin biosynthetic process;GO:0070062,cellular_component extracellular exosome	NA	D-dopachrome tautomerase [Source:HGNC Symbol%3BAcc:HGNC:2732]
ENSG00000091656	8.62	10.87	9.30	9.27	11.44	9.61	-0.0651368388197052	6.75333985252216	0.502666649188326	0.824362678871013	8:76681218-76867285:+	ZFHX4	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger homeobox 4 [Source:HGNC Symbol%3BAcc:HGNC:30939]
ENSG00000101745	10.07	10.33	10.19	10.13	11.58	10.18	-0.0483338457640564	6.02040218902062	0.502803669285997	0.824374041655115	18:9136227-9285985:+	ANKRD12	3;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol	NA	ankyrin repeat domain 12 [Source:HGNC Symbol%3BAcc:HGNC:29135]
ENSG00000179476	11.77	10.28	9.34	8.61	9.22	11.64	0.101780205693236	3.26401967899376	0.502861596682326	0.824374041655115	14:44897294-44907257:+	C14orf28	NA	NA	chromosome 14 open reading frame 28 [Source:HGNC Symbol%3BAcc:HGNC:19834]
ENSG00000134013	291.22	284.52	292.30	282.35	285.86	284.64	0.0373073671266954	9.53602249529894	0.502878968246196	0.824374041655115	8:23297188-23425328:-	LOXL2	40;GO:0001666,biological_process response to hypoxia;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001935,biological_process endothelial cell proliferation;GO:0002040,biological_process sprouting angiogenesis;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004720,molecular_function protein-lysine 6-oxidase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006464,biological_process cellular protein modification process;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007155,biological_process cell adhesion;GO:0007568,biological_process aging;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016570,biological_process histone modification;GO:0016641,molecular_function oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0018277,biological_process protein deamination;GO:0030199,biological_process collagen fibril organization;GO:0031012,cellular_component extracellular matrix;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0035064,molecular_function methylated histone binding;GO:0043542,biological_process endothelial cell migration;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070492,molecular_function oligosaccharide binding	NA	lysyl oxidase like 2 [Source:HGNC Symbol%3BAcc:HGNC:6666]
ENSG00000103274	23.03	23.10	22.00	24.65	23.15	23.66	-0.0583901693349639	4.49168394030629	0.503040268864205	0.824374041655115	16:10743785-10769351:+	NUBP1	23;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006879,biological_process cellular iron ion homeostasis;GO:0010826,biological_process negative regulation of centrosome duplication;GO:0016049,biological_process cell growth;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0030030,biological_process cell projection organization;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0051642,biological_process centrosome localization;GO:0070062,cellular_component extracellular exosome;GO:0072697,biological_process protein localization to cell cortex	NA	nucleotide binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8041]
ENSG00000021762	14.62	15.11	14.21	14.11	14.24	14.48	0.0461684493675232	5.25862182960257	0.503049733399545	0.824374041655115	11:3087115-3166739:-	OSBPL5	19;GO:0001786,molecular_function phosphatidylserine binding;GO:0005548,molecular_function phospholipid transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0008142,molecular_function oxysterol binding;GO:0008203,biological_process cholesterol metabolic process;GO:0008289,molecular_function lipid binding;GO:0015485,molecular_function cholesterol binding;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030301,biological_process cholesterol transport;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	oxysterol binding protein like 5 [Source:HGNC Symbol%3BAcc:HGNC:16392]
ENSG00000166822	5.67	7.67	5.30	7.24	6.24	7.09	-0.155726597339925	1.72616097819389	0.503072050715983	0.824374041655115	16:75443053-75465497:-	TMEM170A	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006998,biological_process nuclear envelope organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051292,biological_process nuclear pore complex assembly;GO:0071786,biological_process endoplasmic reticulum tubular network organization	NA	transmembrane protein 170A [Source:HGNC Symbol%3BAcc:HGNC:29577]
ENSG00000157827	39.04	36.83	41.34	35.78	38.59	40.10	0.0471093661966668	7.02477644969764	0.503312454848884	0.824659121177296	2:152335236-152649834:+	FMNL2	10;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007010,biological_process cytoskeleton organization;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030036,biological_process actin cytoskeleton organization;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0045296,molecular_function cadherin binding	NA	formin like 2 [Source:HGNC Symbol%3BAcc:HGNC:18267]
ENSG00000100353	192.18	184.89	198.00	205.88	185.62	206.03	-0.0432101979879043	8.3896366095992	0.503903668789452	0.825483223364652	22:36510849-36529436:-	EIF3D	17;GO:0001732,biological_process formation of cytoplasmic translation initiation complex;GO:0002191,biological_process cap-dependent translational initiation;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0016020,cellular_component membrane;GO:0045727,biological_process positive regulation of translation;GO:0071541,cellular_component eukaryotic translation initiation factor 3 complex, eIF3m;GO:0075522,biological_process IRES-dependent viral translational initiation;GO:0075525,biological_process viral translational termination-reinitiation;GO:0098808,molecular_function mRNA cap binding;GO:1902416,biological_process positive regulation of mRNA binding	EIF3D; translation initiation factor 3 subunit D; K03251	eukaryotic translation initiation factor 3 subunit D [Source:HGNC Symbol%3BAcc:HGNC:3278]
ENSG00000180917	11.43	11.25	13.16	12.06	12.41	13.21	-0.0576208800824799	4.83389299910439	0.503959586317997	0.825483223364652	16:71281388-71289715:-	CMTR2	9;GO:0004483,molecular_function mRNA (nucleoside-2'-O-)-methyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006397,biological_process mRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0097310,biological_process cap2 mRNA methylation	NA	cap methyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:25635]
ENSG00000072954	3.40	3.86	3.22	3.93	2.90	2.54	0.166922758303205	1.65851649826487	0.504014931916595	0.825483223364652	19:16661126-16690029:+	TMEM38A	16;GO:0005261,molecular_function cation channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005634,cellular_component nucleus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0015269,molecular_function calcium-activated potassium channel activity;GO:0015672,biological_process monovalent inorganic cation transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0031965,cellular_component nuclear membrane;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0070062,cellular_component extracellular exosome;GO:0071805,biological_process potassium ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	transmembrane protein 38A [Source:HGNC Symbol%3BAcc:HGNC:28462]
ENSG00000150401	5.55	5.74	6.17	6.08	6.56	6.14	-0.0928485734691618	2.8081860773811	0.504329440052075	0.825659460779385	13:113455818-113490952:-	DCUN1D2	6;GO:0000151,cellular_component ubiquitin ligase complex;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032182,molecular_function ubiquitin-like protein binding;GO:0045116,biological_process protein neddylation;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0097602,molecular_function cullin family protein binding	NA	defective in cullin neddylation 1 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20328]
ENSG00000213077	1.39	1.70	2.47	1.03	1.35	2.08	0.318901688881414	0.00089718770387065	0.50433202968812	0.825659460779385	17:18524565-18526846:-	FAM106A	NA	NA	family with sequence similarity 106 member A [Source:HGNC Symbol%3BAcc:HGNC:25682]
ENSG00000197497	0.66	1.50	1.01	1.07	0.60	1.04	0.206733344969377	1.07427221229567	0.504393083967979	0.825659460779385	19:53159212-53193386:-	ZNF665	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 665 [Source:HGNC Symbol%3BAcc:HGNC:25885]
ENSG00000154237	3.94	4.22	3.82	4.45	4.09	4.01	-0.0604022115330149	4.66100869728517	0.504434730267701	0.825659460779385	15:100919214-101078254:+	LRRK1	24;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0036035,biological_process osteoclast development;GO:0042802,molecular_function identical protein binding;GO:0045453,biological_process bone resorption;GO:0046872,molecular_function metal ion binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050732,biological_process negative regulation of peptidyl-tyrosine phosphorylation;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902533,biological_process positive regulation of intracellular signal transduction	NA	leucine rich repeat kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:18608]
ENSG00000197776	3.26	2.74	3.39	2.66	3.04	2.98	0.138765700547872	2.05408816950602	0.504487783765023	0.825659460779385	14:49693104-49753152:+	KLHDC1	2;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	kelch domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19836]
ENSG00000114127	5.28	5.49	6.26	5.89	5.98	6.01	-0.0566622201165159	4.91425809494396	0.504580584837656	0.825659460779385	3:142306606-142448062:-	XRN1	33;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0002151,molecular_function G-quadruplex RNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004534,molecular_function 5'-3' exoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0016020,cellular_component membrane;GO:0016075,biological_process rRNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0017148,biological_process negative regulation of translation;GO:0030425,cellular_component dendrite;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0033574,biological_process response to testosterone;GO:0043025,cellular_component neuronal cell body;GO:0043488,biological_process regulation of mRNA stability;GO:0045202,cellular_component synapse;GO:0051880,molecular_function G-quadruplex DNA binding;GO:0070034,molecular_function telomerase RNA binding;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071044,biological_process histone mRNA catabolic process;GO:0071409,biological_process cellular response to cycloheximide;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:1905795,biological_process cellular response to puromycin	XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]; K12618	5'-3' exoribonuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:30654]
ENSG00000113492	1.05	2.05	1.62	1.55	2.21	1.60	-0.197246511037875	1.44038124785885	0.50458814706134	0.825659460779385	5:34998100-35048135:-	AGXT2	14;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008453,molecular_function alanine-glyoxylate transaminase activity;GO:0008483,molecular_function transaminase activity;GO:0009436,biological_process glyoxylate catabolic process;GO:0016740,molecular_function transferase activity;GO:0019265,biological_process glycine biosynthetic process, by transamination of glyoxylate;GO:0019481,biological_process L-alanine catabolic process, by transamination;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042802,molecular_function identical protein binding;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0046487,biological_process glyoxylate metabolic process;GO:0047305,molecular_function (R)-3-amino-2-methylpropionate-pyruvate transaminase activity	AGXT2; alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase [EC:2.6.1.44 2.6.1.40]; K00827	alanine--glyoxylate aminotransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:14412]
ENSG00000149182	28.32	30.70	29.60	31.06	31.16	29.93	-0.0467790898869625	5.71892094520832	0.504710439541607	0.825750716492681	11:47164298-47177125:-	ARFGAP2	14;GO:0000139,cellular_component Golgi membrane;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3; K12493	ADP ribosylation factor GTPase activating protein 2 [Source:HGNC Symbol%3BAcc:HGNC:13504]
ENSG00000138744	8.20	8.26	7.27	7.21	6.74	8.45	0.0881977169456659	3.24627315882223	0.50479103694124	0.825761953810293	4:75913656-75941051:-	NAAA	11;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0006629,biological_process lipid metabolic process;GO:0007269,biological_process neurotransmitter secretion;GO:0008134,molecular_function transcription factor binding;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0043202,cellular_component lysosomal lumen;GO:0070062,cellular_component extracellular exosome;GO:0098793,cellular_component presynapse	NA	N-acylethanolamine acid amidase [Source:HGNC Symbol%3BAcc:HGNC:736]
ENSG00000026025	4089.07	3767.52	4027.51	4016.03	3652.85	3968.71	0.0419861606834918	12.4598303381632	0.504900859941019	0.825761953810293	10:17228258-17237593:+	VIM	32;GO:0003725,molecular_function double-stranded RNA binding;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005212,molecular_function structural constituent of eye lens;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0008022,molecular_function protein C-terminus binding;GO:0010628,biological_process positive regulation of gene expression;GO:0010977,biological_process negative regulation of neuron projection development;GO:0014002,biological_process astrocyte development;GO:0016032,biological_process viral process;GO:0030049,biological_process muscle filament sliding;GO:0031012,cellular_component extracellular matrix;GO:0031252,cellular_component cell leading edge;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0045103,biological_process intermediate filament-based process;GO:0045109,biological_process intermediate filament organization;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060395,biological_process SMAD protein signal transduction;GO:0070062,cellular_component extracellular exosome;GO:0070307,biological_process lens fiber cell development;GO:0097110,molecular_function scaffold protein binding;GO:1990254,molecular_function keratin filament binding	VIM; vimentin; K07606	vimentin [Source:HGNC Symbol%3BAcc:HGNC:12692]
ENSG00000067057	294.40	274.65	288.81	310.96	277.44	302.60	-0.0427977851611884	9.57694417214907	0.504937169654387	0.825761953810293	10:3066332-3137712:+	PFKP	22;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003872,molecular_function 6-phosphofructokinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006002,biological_process fructose 6-phosphate metabolic process;GO:0006096,biological_process glycolytic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031012,cellular_component extracellular matrix;GO:0032403,molecular_function protein complex binding;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0061615,biological_process glycolytic process through fructose-6-phosphate;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome;GO:1990830,biological_process cellular response to leukemia inhibitory factor	pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]; K00850	phosphofructokinase%2C platelet [Source:HGNC Symbol%3BAcc:HGNC:8878]
ENSG00000197863	3.22	2.70	2.58	3.77	2.66	2.91	-0.117069480797756	2.54814383680225	0.504983403800365	0.825761953810293	19:36817427-36850787:-	ZNF790	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 790 [Source:HGNC Symbol%3BAcc:HGNC:33114]
ENSG00000159921	15.43	17.96	15.83	16.74	14.83	16.08	0.0526972785836163	5.25393168035367	0.505162337469607	0.825945744864361	9:36214440-36277056:-	GNE	20;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006045,biological_process N-acetylglucosamine biosynthetic process;GO:0006047,biological_process UDP-N-acetylglucosamine metabolic process;GO:0006054,biological_process N-acetylneuraminate metabolic process;GO:0007155,biological_process cell adhesion;GO:0008152,biological_process metabolic process;GO:0008761,molecular_function UDP-N-acetylglucosamine 2-epimerase activity;GO:0009384,molecular_function N-acylmannosamine kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0046835,biological_process carbohydrate phosphorylation;GO:0046872,molecular_function metal ion binding	GNE; bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase [EC:3.2.1.183 2.7.1.60]; K12409	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [Source:HGNC Symbol%3BAcc:HGNC:23657]
ENSG00000275835	8.84	8.60	8.58	7.95	8.93	8.39	0.0546144963441678	4.81655666820367	0.505289616039609	0.826045041999165	15:22983191-23039673:-	TUBGCP5	20;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000922,cellular_component spindle pole;GO:0000923,cellular_component equatorial microtubule organizing center;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007020,biological_process microtubule nucleation;GO:0008017,molecular_function microtubule binding;GO:0008274,cellular_component gamma-tubulin ring complex;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0043015,molecular_function gamma-tubulin binding;GO:0051011,molecular_function microtubule minus-end binding;GO:0051298,biological_process centrosome duplication;GO:0051321,biological_process meiotic cell cycle;GO:0051415,biological_process interphase microtubule nucleation by interphase microtubule organizing center;GO:0090307,biological_process mitotic spindle assembly	NA	tubulin gamma complex associated protein 5 [Source:HGNC Symbol%3BAcc:HGNC:18600]
ENSG00000261934	0.52	0.50	0.59	0.55	0.58	0.27	0.226328288749446	0.663484383324901	0.505427067683291	0.826141865247098	5:141402931-141512979:+	PCDHGA9	11;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007283,biological_process spermatogenesis;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protocadherin gamma subfamily A%2C 9 [Source:HGNC Symbol%3BAcc:HGNC:8707]
ENSG00000173660	319.03	334.37	282.95	318.68	326.11	330.51	-0.0484208403654604	7.12325334194937	0.505481951708024	0.826141865247098	1:46303630-46316776:+	UQCRH	13;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006119,biological_process oxidative phosphorylation;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6; K00416	ubiquinol-cytochrome c reductase hinge protein [Source:HGNC Symbol%3BAcc:HGNC:12590]
ENSG00000170989	9.61	13.34	9.44	10.26	13.70	10.98	-0.108404610313262	3.69321380408818	0.505598140645882	0.826222975228718	1:101236887-101241518:+	S1PR1	44;GO:0001525,biological_process angiogenesis;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001955,biological_process blood vessel maturation;GO:0003245,biological_process cardiac muscle tissue growth involved in heart morphogenesis;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007420,biological_process brain development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0019226,biological_process transmission of nerve impulse;GO:0030032,biological_process lamellipodium assembly;GO:0030155,biological_process regulation of cell adhesion;GO:0030182,biological_process neuron differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030500,biological_process regulation of bone mineralization;GO:0030595,biological_process leukocyte chemotaxis;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0038036,molecular_function sphingosine-1-phosphate receptor activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045121,cellular_component membrane raft;GO:0045124,biological_process regulation of bone resorption;GO:0045446,biological_process endothelial cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046625,molecular_function sphingolipid binding;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0061384,biological_process heart trabecula morphogenesis;GO:0072678,biological_process T cell migration	S1PR1, EDG1, CD363; sphingosine 1-phosphate receptor 1; K04288	sphingosine-1-phosphate receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:3165]
ENSG00000130348	20.87	18.53	21.62	23.05	19.36	21.74	-0.0562683404691396	5.15148403339961	0.505710311291934	0.826285803838252	6:106629577-106668417:+	QRSL1	11;GO:0000166,molecular_function nucleotide binding;GO:0004040,molecular_function amidase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0016874,molecular_function ligase activity;GO:0030956,cellular_component glutamyl-tRNA(Gln) amidotransferase complex;GO:0031647,biological_process regulation of protein stability;GO:0032543,biological_process mitochondrial translation;GO:0050567,molecular_function glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity;GO:0070681,biological_process glutaminyl-tRNAGln biosynthesis via transamidation	NA	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 [Source:HGNC Symbol%3BAcc:HGNC:21020]
ENSG00000196363	35.24	35.86	38.71	40.13	35.73	38.95	-0.0519199945548577	5.23678442383575	0.505817986899918	0.826285803838252	9:134135364-134159968:+	WDR5	31;GO:0000123,cellular_component histone acetyltransferase complex;GO:0001501,biological_process skeletal system development;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0031175,biological_process neuron projection development;GO:0035064,molecular_function methylated histone binding;GO:0035097,cellular_component histone methyltransferase complex;GO:0035948,biological_process positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter;GO:0036064,cellular_component ciliary basal body;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0043687,biological_process post-translational protein modification;GO:0043966,biological_process histone H3 acetylation;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0044666,cellular_component MLL3/4 complex;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific);GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation;GO:0060271,biological_process cilium morphogenesis;GO:0071339,cellular_component MLL1 complex	WDR5, SWD3, CPS30; COMPASS component SWD3; K14963	WD repeat domain 5 [Source:HGNC Symbol%3BAcc:HGNC:12757]
ENSG00000184465	18.31	16.27	19.22	19.72	16.99	19.73	-0.0538121349617652	5.65039851571914	0.505836286422853	0.826285803838252	6:169457211-169702048:-	WDR27	2;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm	NA	WD repeat domain 27 [Source:HGNC Symbol%3BAcc:HGNC:21248]
ENSG00000035115	32.33	29.82	30.62	32.74	29.22	35.25	-0.0547260254454354	5.2236850241926	0.506311422024536	0.826953115998758	2:217729-266398:-	SH3YL1	6;GO:0005515,molecular_function protein binding;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0019902,molecular_function phosphatase binding;GO:0032587,cellular_component ruffle membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:1900027,biological_process regulation of ruffle assembly	NA	SH3 and SYLF domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29546]
ENSG00000175582	77.30	76.58	81.16	85.13	78.75	80.63	-0.0441232244113078	5.87177164587773	0.506869754955846	0.827579511771752	11:73675637-73761137:-	RAB6A	33;GO:0000042,biological_process protein targeting to Golgi;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016192,biological_process vesicle-mediated transport;GO:0018125,biological_process peptidyl-cysteine methylation;GO:0019882,biological_process antigen processing and presentation;GO:0019904,molecular_function protein domain specific binding;GO:0030667,cellular_component secretory granule membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0034498,biological_process early endosome to Golgi transport;GO:0043312,biological_process neutrophil degranulation;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070381,cellular_component endosome to plasma membrane transport vesicle;GO:0072385,biological_process minus-end-directed organelle transport along microtubule	NA	RAB6A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9786]
ENSG00000185621	5.68	4.97	3.76	4.33	4.60	4.61	0.101048344713619	3.29556688152904	0.506951903753725	0.827579511771752	3:197960199-198043720:+	LMLN	15;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0007049,biological_process cell cycle;GO:0007155,biological_process cell adhesion;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	NA	leishmanolysin like peptidase [Source:HGNC Symbol%3BAcc:HGNC:15991]
ENSG00000127445	81.93	84.53	81.25	78.83	84.48	78.56	0.0451232887462416	5.63219744716405	0.506963684867706	0.827579511771752	19:9835256-9849682:+	PIN1	42;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008013,molecular_function beta-catenin binding;GO:0016607,cellular_component nuclear speck;GO:0016853,molecular_function isomerase activity;GO:0030182,biological_process neuron differentiation;GO:0030496,cellular_component midbody;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0032091,biological_process negative regulation of protein binding;GO:0032465,biological_process regulation of cytokinesis;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032794,molecular_function GTPase activating protein binding;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0043005,cellular_component neuron projection;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050808,biological_process synapse organization;GO:0050815,molecular_function phosphoserine binding;GO:0050816,molecular_function phosphothreonine binding;GO:0050821,biological_process protein stabilization;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0060393,biological_process regulation of pathway-restricted SMAD protein phosphorylation;GO:0061051,biological_process positive regulation of cell growth involved in cardiac muscle cell development;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1900180,biological_process regulation of protein localization to nucleus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2000146,biological_process negative regulation of cell motility	PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]; K09578	peptidylprolyl cis/trans isomerase%2C NIMA-interacting 1 [Source:HGNC Symbol%3BAcc:HGNC:8988]
ENSG00000169184	1.94	1.35	1.58	1.21	1.44	1.86	0.132146092425021	2.67753446621884	0.507029050650887	0.827579511771752	22:27748276-27801498:-	MN1	7;GO:0001957,biological_process intramembranous ossification;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process	NA	MN1 proto-oncogene%2C transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:7180]
ENSG00000073803	4.50	4.62	4.66	4.40	4.21	4.62	0.0684417749816523	3.80084420676088	0.507039135834098	0.827579511771752	3:185282940-185489097:+	MAP3K13	22;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007254,biological_process JNK cascade;GO:0008385,cellular_component IkappaB kinase complex;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]; K04422	mitogen-activated protein kinase kinase kinase 13 [Source:HGNC Symbol%3BAcc:HGNC:6852]
ENSG00000141384	2.80	2.48	2.24	3.14	2.49	2.55	-0.104603635720438	2.81307802013396	0.507094962260206	0.827579511771752	18:26225935-26391685:+	TAF4B	24;GO:0001075,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048477,biological_process oogenesis;GO:0051059,molecular_function NF-kappaB binding;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2000648,biological_process positive regulation of stem cell proliferation	TAF4; transcription initiation factor TFIID subunit 4; K03129	TATA-box binding protein associated factor 4b [Source:HGNC Symbol%3BAcc:HGNC:11538]
ENSG00000155666	1.56	1.82	1.68	1.92	2.12	1.65	-0.165074743516616	1.3701395269226	0.507173704168849	0.827599209918222	16:27203494-27221768:+	KDM8	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0032452,molecular_function histone demethylase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation	NA	lysine demethylase 8 [Source:HGNC Symbol%3BAcc:HGNC:25840]
ENSG00000173349	4.49	3.70	3.42	3.48	3.06	3.92	0.164923864510214	1.34071013924565	0.507308977720402	0.827670186840423	2:127701507-127705242:+	SFT2D3	5;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport	NA	SFT2 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28767]
ENSG00000065833	60.62	64.38	62.79	56.90	65.32	61.10	0.0458301905293482	6.73224390183779	0.507350556003285	0.827670186840423	6:83210388-83431071:-	ME1	24;GO:0004470,molecular_function malic enzyme activity;GO:0004471,molecular_function malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004473,molecular_function malate dehydrogenase (decarboxylating) (NADP+) activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006090,biological_process pyruvate metabolic process;GO:0006108,biological_process malate metabolic process;GO:0006741,biological_process NADP biosynthetic process;GO:0008948,molecular_function oxaloacetate decarboxylase activity;GO:0009055,molecular_function electron carrier activity;GO:0009725,biological_process response to hormone;GO:0009743,biological_process response to carbohydrate;GO:0016491,molecular_function oxidoreductase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030145,molecular_function manganese ion binding;GO:0043531,molecular_function ADP binding;GO:0046872,molecular_function metal ion binding;GO:0050661,molecular_function NADP binding;GO:0051262,biological_process protein tetramerization;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:1902031,biological_process regulation of NADP metabolic process	E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]; K00029	malic enzyme 1 [Source:HGNC Symbol%3BAcc:HGNC:6983]
ENSG00000147127	2.12	3.01	2.32	2.36	2.39	1.69	0.203152260296244	0.742817007030232	0.507444300498804	0.827714336674331	X:70282092-70285002:+	RAB41	11;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0042147,biological_process retrograde transport, endosome to Golgi	NA	RAB41%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:18293]
ENSG00000130816	19.27	21.08	17.78	20.09	20.58	19.88	-0.0492589168699775	6.70781287939435	0.507630730534381	0.827909638434275	19:10133344-10231286:-	DNMT1	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000792,cellular_component heterochromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003886,molecular_function DNA (cytosine-5-)-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005721,cellular_component pericentric heterochromatin;GO:0006306,biological_process DNA methylation;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007265,biological_process Ras protein signal transduction;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0008327,molecular_function methyl-CpG binding;GO:0009008,molecular_function DNA-methyltransferase activity;GO:0010216,biological_process maintenance of DNA methylation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0016458,biological_process gene silencing;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0032776,biological_process DNA methylation on cytosine;GO:0042127,biological_process regulation of cell proliferation;GO:0043045,biological_process DNA methylation involved in embryo development;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0051573,biological_process negative regulation of histone H3-K9 methylation;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0090116,biological_process C-5 methylation of cytosine;GO:0090309,biological_process positive regulation of methylation-dependent chromatin silencing;GO:1990841,molecular_function promoter-specific chromatin binding	DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]; K00558	DNA methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:2976]
ENSG00000198453	1.40	0.75	1.23	1.48	1.27	1.06	-0.136101302002422	2.17046686266535	0.508132015858055	0.828618328014455	19:36916328-36998700:+	ZNF568	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 568 [Source:HGNC Symbol%3BAcc:HGNC:25392]
ENSG00000135679	7.99	8.08	8.37	8.97	8.26	8.64	-0.0700036028326022	3.80271071842877	0.508534890574318	0.829003680798757	12:68808175-68850686:+	MDM2	101;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001568,biological_process blood vessel development;GO:0001974,biological_process blood vessel remodeling;GO:0002027,biological_process regulation of heart rate;GO:0002039,molecular_function p53 binding;GO:0003170,biological_process heart valve development;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003281,biological_process ventricular septum development;GO:0003283,biological_process atrial septum development;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007089,biological_process traversing start control point of mitotic cell cycle;GO:0007507,biological_process heart development;GO:0008097,molecular_function 5S rRNA binding;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009636,biological_process response to toxic substance;GO:0010039,biological_process response to iron ion;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010955,biological_process negative regulation of protein processing;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0018205,biological_process peptidyl-lysine modification;GO:0019789,molecular_function SUMO transferase activity;GO:0019899,molecular_function enzyme binding;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031648,biological_process protein destabilization;GO:0032026,biological_process response to magnesium ion;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034504,biological_process protein localization to nucleus;GO:0036369,biological_process transcription factor catabolic process;GO:0042176,biological_process regulation of protein catabolic process;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043234,cellular_component protein complex;GO:0043278,biological_process response to morphine;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045184,biological_process establishment of protein localization;GO:0045202,cellular_component synapse;GO:0045472,biological_process response to ether;GO:0045787,biological_process positive regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046677,biological_process response to antibiotic;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0048545,biological_process response to steroid hormone;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0051865,biological_process protein autoubiquitination;GO:0060411,biological_process cardiac septum morphogenesis;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061663,molecular_function NEDD8 ligase activity;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071236,biological_process cellular response to antibiotic;GO:0071301,biological_process cellular response to vitamin B1;GO:0071310,biological_process cellular response to organic substance;GO:0071312,biological_process cellular response to alkaloid;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0071391,biological_process cellular response to estrogen stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071456,biological_process cellular response to hypoxia;GO:0071480,biological_process cellular response to gamma radiation;GO:0071494,biological_process cellular response to UV-C;GO:0072717,biological_process cellular response to actinomycin D;GO:0097110,molecular_function scaffold protein binding;GO:0097718,molecular_function disordered domain specific binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1901797,biological_process negative regulation of signal transduction by p53 class mediator;GO:1902254,biological_process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:1904404,biological_process response to formaldehyde;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:1990000,biological_process amyloid fibril formation;GO:1990785,biological_process response to water-immersion restraint stress	MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]; K06643	MDM2 proto-oncogene [Source:HGNC Symbol%3BAcc:HGNC:6973]
ENSG00000186280	1.22	1.10	1.22	1.19	1.26	1.61	-0.187376584927483	1.10585628958043	0.508535828743126	0.829003680798757	11:94973680-94999518:+	KDM4D	19;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0035563,biological_process positive regulation of chromatin binding;GO:0035861,cellular_component site of double-strand break;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0071479,biological_process cellular response to ionizing radiation;GO:0072562,cellular_component blood microparticle;GO:2001034,biological_process positive regulation of double-strand break repair via nonhomologous end joining	NA	lysine demethylase 4D [Source:HGNC Symbol%3BAcc:HGNC:25498]
ENSG00000221955	19.07	19.99	19.65	19.37	18.72	19.23	0.0444072189774304	5.47062658414144	0.508604359680134	0.829003680798757	3:125082635-125212864:-	SLC12A8	12;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006821,biological_process chloride transport;GO:0015293,molecular_function symporter activity;GO:0015379,molecular_function potassium:chloride symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022820,molecular_function potassium ion symporter activity;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 12 member 8 [Source:HGNC Symbol%3BAcc:HGNC:15595]
ENSG00000116096	22.19	21.97	19.18	19.22	20.92	20.66	0.0676862400522824	4.03029338743041	0.508635465476785	0.829003680798757	2:72887359-72892158:+	SPR	12;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0004757,molecular_function sepiapterin reductase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006729,biological_process tetrahydrobiopterin biosynthetic process;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0050661,molecular_function NADP binding;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	SPR; sepiapterin reductase [EC:1.1.1.153]; K00072	sepiapterin reductase (7%2C8-dihydrobiopterin:NADP+ oxidoreductase) [Source:HGNC Symbol%3BAcc:HGNC:11257]
ENSG00000063180	6.07	3.91	5.37	4.79	4.39	5.06	0.139337184644637	2.36031474330598	0.508938706795653	0.829129818865574	19:48637941-48646312:-	CA11	2;GO:0005576,cellular_component extracellular region;GO:0016323,cellular_component basolateral plasma membrane	NA	carbonic anhydrase 11 [Source:HGNC Symbol%3BAcc:HGNC:1370]
ENSG00000175356	0.52	0.95	0.61	0.65	0.44	0.70	0.195584140526806	1.0912018739214	0.508974886652568	0.829129818865574	11:9020390-9138114:-	SCUBE2	6;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0030154,biological_process cell differentiation	NA	signal peptide%2C CUB domain and EGF like domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30425]
ENSG00000163141	0.92	1.60	0.82	1.11	0.49	1.11	0.256623091004213	0.283228773229271	0.509037792072772	0.829129818865574	1:151036569-151047600:+	BNIPL	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0040009,biological_process regulation of growth rate;GO:0042802,molecular_function identical protein binding	NA	BCL2 interacting protein like [Source:HGNC Symbol%3BAcc:HGNC:16976]
ENSG00000048028	13.80	12.87	13.59	13.63	13.77	14.52	-0.0441286461410127	5.60051716203211	0.509048056276782	0.829129818865574	11:113797873-113875570:-	USP28	22;GO:0000077,biological_process DNA damage checkpoint;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007265,biological_process Ras protein signal transduction;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008283,biological_process cell proliferation;GO:0010212,biological_process response to ionizing radiation;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0031647,biological_process regulation of protein stability;GO:0034644,biological_process cellular response to UV;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043234,cellular_component protein complex	USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]; K11849	ubiquitin specific peptidase 28 [Source:HGNC Symbol%3BAcc:HGNC:12625]
ENSG00000124920	16.18	16.45	16.92	16.35	16.59	15.52	0.0441933955850557	5.83130534408186	0.509063217827587	0.829129818865574	11:61752641-61788518:+	MYRF	23;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0014003,biological_process oligodendrocyte development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0022010,biological_process central nervous system myelination;GO:0030154,biological_process cell differentiation;GO:0031643,biological_process positive regulation of myelination;GO:0032286,biological_process central nervous system myelin maintenance;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048709,biological_process oligodendrocyte differentiation	NA	myelin regulatory factor [Source:HGNC Symbol%3BAcc:HGNC:1181]
ENSG00000198786	3037.61	3369.68	3211.27	2980.85	3433.83	2962.57	0.0484326854335375	12.4848452016876	0.50911362921078	0.829129818865574	MT:12336-14148:+	MT-ND5	17;GO:0001666,biological_process response to hypoxia;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0010243,biological_process response to organonitrogen compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0042542,biological_process response to hydrogen peroxide;GO:0042773,biological_process ATP synthesis coupled electron transport;GO:0043005,cellular_component neuron projection;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]; K03883	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:7461]
ENSG00000141456	19.79	20.01	21.18	21.69	21.29	20.39	-0.0431787056612687	6.21438875726613	0.509181153484759	0.829131005930252	17:4669773-4704337:-	PELP1	14;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0008134,molecular_function transcription factor binding;GO:0035327,cellular_component transcriptionally active chromatin;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0071339,cellular_component MLL1 complex;GO:0071391,biological_process cellular response to estrogen stimulus	NA	proline%2C glutamate and leucine rich protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30134]
ENSG00000066697	47.94	52.00	48.87	46.33	46.93	51.55	0.0470861521302976	5.43964951032192	0.509475230785433	0.829353702098812	9:100427155-100451711:+	MSANTD3	1;GO:0042802,molecular_function identical protein binding	NA	Myb/SANT DNA binding domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:23370]
ENSG00000100519	88.84	92.17	87.29	92.18	92.64	93.40	-0.0417597502228423	6.81858985357735	0.509539261237483	0.829353702098812	14:52707171-52728587:+	PSMC6	51;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017025,molecular_function TBP-class protein binding;GO:0022624,cellular_component proteasome accessory complex;GO:0030163,biological_process protein catabolic process;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030674,molecular_function protein binding, bridging;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031595,cellular_component nuclear proteasome complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0036402,molecular_function proteasome-activating ATPase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090261,biological_process positive regulation of inclusion body assembly;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMC6, RPT4; 26S proteasome regulatory subunit T4; K03064	proteasome 26S subunit%2C ATPase 6 [Source:HGNC Symbol%3BAcc:HGNC:9553]
ENSG00000159176	115.96	116.01	110.80	118.87	121.23	115.67	-0.0423683168064292	6.23426619322747	0.509563572516782	0.829353702098812	1:201483529-201509456:-	CSRP1	7;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005925,cellular_component focal adhesion;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation	NA	cysteine and glycine rich protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2469]
ENSG00000141424	40.81	40.68	38.65	40.10	43.59	41.16	-0.0441515178880699	6.53997020713762	0.509585167639381	0.829353702098812	18:36108531-36129385:-	SLC39A6	17;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0031258,cellular_component lamellipodium membrane;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0071577,biological_process zinc II ion transmembrane transport;GO:0071578,biological_process zinc II ion transmembrane import	NA	solute carrier family 39 member 6 [Source:HGNC Symbol%3BAcc:HGNC:18607]
ENSG00000165698	15.59	15.43	17.45	15.09	15.96	15.31	0.0797868755873599	3.43695848469541	0.510086319134357	0.829815043564118	9:132878026-132890201:+	SPACA9	6;GO:0001669,cellular_component acrosomal vesicle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005881,cellular_component cytoplasmic microtubule;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048306,molecular_function calcium-dependent protein binding	NA	sperm acrosome associated 9 [Source:HGNC Symbol%3BAcc:HGNC:1367]
ENSG00000165175	85.03	66.84	89.55	95.33	73.77	87.23	-0.0703930147793862	5.51933346434851	0.510090212065784	0.829815043564118	X:38801431-38806537:+	MID1IP1	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006629,biological_process lipid metabolic process;GO:0006853,biological_process carnitine shuttle;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0008022,molecular_function protein C-terminus binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0045723,biological_process positive regulation of fatty acid biosynthetic process;GO:0046890,biological_process regulation of lipid biosynthetic process;GO:0051258,biological_process protein polymerization;GO:0051351,biological_process positive regulation of ligase activity	NA	MID1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20715]
ENSG00000065413	3.43	2.96	3.22	2.90	3.15	3.15	0.0840689675865137	3.32006102501706	0.510116473704865	0.829815043564118	2:196967016-197311173:-	ANKRD44	1;GO:0005515,molecular_function protein binding	NA	ankyrin repeat domain 44 [Source:HGNC Symbol%3BAcc:HGNC:25259]
ENSG00000132669	21.70	21.43	21.91	21.63	23.00	22.89	-0.042008637980122	5.97210825462986	0.51013603459581	0.829815043564118	20:19886520-20002457:+	RIN2	12;GO:0005096,molecular_function GTPase activator activity;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030695,molecular_function GTPase regulator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050790,biological_process regulation of catalytic activity;GO:0061024,biological_process membrane organization	NA	Ras and Rab interactor 2 [Source:HGNC Symbol%3BAcc:HGNC:18750]
ENSG00000162409	6.80	5.23	6.33	7.20	6.66	5.92	-0.0830148905121051	3.42971448910679	0.510223764047045	0.829849001980604	1:56645321-56715335:+	PRKAA2	63;GO:0000166,molecular_function nucleotide binding;GO:0003682,molecular_function chromatin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004679,molecular_function AMP-activated protein kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006853,biological_process carnitine shuttle;GO:0006914,biological_process autophagy;GO:0006950,biological_process response to stress;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008610,biological_process lipid biosynthetic process;GO:0010468,biological_process regulation of gene expression;GO:0010508,biological_process positive regulation of autophagy;GO:0014850,biological_process response to muscle activity;GO:0016055,biological_process Wnt signaling pathway;GO:0016126,biological_process sterol biosynthetic process;GO:0016236,biological_process macroautophagy;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0031669,biological_process cellular response to nutrient levels;GO:0032007,biological_process negative regulation of TOR signaling;GO:0035174,molecular_function histone serine kinase activity;GO:0035404,biological_process histone-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0035690,biological_process cellular response to drug;GO:0042149,biological_process cellular response to glucose starvation;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0042593,biological_process glucose homeostasis;GO:0042752,biological_process regulation of circadian rhythm;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045821,biological_process positive regulation of glycolytic process;GO:0046872,molecular_function metal ion binding;GO:0047322,molecular_function [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity;GO:0048511,biological_process rhythmic process;GO:0050405,molecular_function [acetyl-CoA carboxylase] kinase activity;GO:0055089,biological_process fatty acid homeostasis;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2000505,biological_process regulation of energy homeostasis	PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]; K07198	protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:9377]
ENSG00000138080	0.42	0.41	0.24	0.42	0.35	0.51	-0.260281805909875	0.42497416503407	0.510439014588748	0.830090329895209	2:27078566-27086408:+	EMILIN1	9;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0030023,molecular_function extracellular matrix constituent conferring elasticity;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0042802,molecular_function identical protein binding	NA	elastin microfibril interfacer 1 [Source:HGNC Symbol%3BAcc:HGNC:19880]
ENSG00000155959	61.02	60.85	56.33	59.54	54.08	59.81	0.0489568966696033	5.29887052025895	0.510546546278275	0.830156442094868	X:155197006-155239817:+	VBP1	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006457,biological_process protein folding;GO:0007017,biological_process microtubule-based process;GO:0007021,biological_process tubulin complex assembly;GO:0015631,molecular_function tubulin binding;GO:0016272,cellular_component prefoldin complex;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	VHL binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:12662]
ENSG00000003096	13.91	15.63	12.04	12.24	15.12	12.43	0.0707448805604833	4.85035295830843	0.510736632698713	0.830321428997656	X:117897812-118117340:-	KLHL13	9;GO:0000910,biological_process cytokinesis;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0030496,cellular_component midbody;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification;GO:0051301,biological_process cell division	NA	kelch like family member 13 [Source:HGNC Symbol%3BAcc:HGNC:22931]
ENSG00000054267	13.95	13.90	14.70	12.47	15.02	13.96	0.0506666427659042	5.87763793073254	0.510840453546494	0.830321428997656	1:235131633-235328219:-	ARID4B	20;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0008150,biological_process biological_process;GO:0016575,biological_process histone deacetylation;GO:0034773,biological_process histone H4-K20 trimethylation;GO:0036124,biological_process histone H3-K9 trimethylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0097368,biological_process establishment of Sertoli cell barrier	NA	AT-rich interaction domain 4B [Source:HGNC Symbol%3BAcc:HGNC:15550]
ENSG00000134278	16.93	13.20	17.36	17.66	13.87	19.07	-0.0759917628544225	5.27270500002263	0.510880442604386	0.830321428997656	18:12446511-12658134:-	SPIRE1	22;GO:0003779,molecular_function actin binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030036,biological_process actin cytoskeleton organization;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032154,cellular_component cleavage furrow;GO:0036089,biological_process cleavage furrow formation;GO:0040038,biological_process polar body extrusion after meiotic divisions;GO:0045010,biological_process actin nucleation;GO:0046907,biological_process intracellular transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051295,biological_process establishment of meiotic spindle localization;GO:0070649,biological_process formin-nucleated actin cable assembly	SPIR; spire; K02098	spire type actin nucleation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:30622]
ENSG00000185090	11.90	14.22	11.33	13.33	11.67	10.67	0.0745763417971208	4.06918052783643	0.510999494943319	0.830321428997656	1:37793801-37801137:+	MANEAL	6;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds	NA	mannosidase endo-alpha like [Source:HGNC Symbol%3BAcc:HGNC:26452]
ENSG00000163251	9.14	10.07	9.94	9.26	9.46	9.34	0.062561301692879	4.07606117340983	0.511020984221432	0.830321428997656	2:207762585-207769563:-	FZD5	60;GO:0000139,cellular_component Golgi membrane;GO:0000578,biological_process embryonic axis specification;GO:0001525,biological_process angiogenesis;GO:0001540,molecular_function beta-amyloid binding;GO:0001944,biological_process vasculature development;GO:0002726,biological_process positive regulation of T cell cytokine production;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007275,biological_process multicellular organism development;GO:0007416,biological_process synapse assembly;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008595,biological_process anterior/posterior axis specification, embryo;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0019901,molecular_function protein kinase binding;GO:0030182,biological_process neuron differentiation;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031076,biological_process embryonic camera-type eye development;GO:0031077,biological_process post-embryonic camera-type eye development;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031901,cellular_component early endosome membrane;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0033077,biological_process T cell differentiation in thymus;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0044332,biological_process Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048469,biological_process cell maturation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0060061,biological_process Spemann organizer formation;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060561,biological_process apoptotic process involved in morphogenesis;GO:0060670,biological_process branching involved in labyrinthine layer morphogenesis;GO:0060715,biological_process syncytiotrophoblast cell differentiation involved in labyrinthine layer development;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0060718,biological_process chorionic trophoblast cell differentiation;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0071219,biological_process cellular response to molecule of bacterial origin;GO:0106003,cellular_component amyloid-beta complex;GO:1901382,biological_process regulation of chorionic trophoblast cell proliferation;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:2000810,biological_process regulation of bicellular tight junction assembly	FZD5_8, fz2; frizzled 5/8; K02375	frizzled class receptor 5 [Source:HGNC Symbol%3BAcc:HGNC:4043]
ENSG00000138376	6.15	5.90	4.95	5.51	5.04	5.68	0.075886997381257	3.72701744508492	0.511083965365635	0.830321428997656	2:214725645-214809711:-	BARD1	35;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001894,biological_process tissue homeostasis;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019900,molecular_function kinase binding;GO:0031436,cellular_component BRCA1-BARD1 complex;GO:0031441,biological_process negative regulation of mRNA 3'-end processing;GO:0042325,biological_process regulation of phosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046826,biological_process negative regulation of protein export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0070531,cellular_component BRCA1-A complex;GO:0085020,biological_process protein K6-linked ubiquitination;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	BARD1; BRCA1-associated RING domain protein 1; K10683	BRCA1 associated RING domain 1 [Source:HGNC Symbol%3BAcc:HGNC:952]
ENSG00000135446	149.67	137.07	135.90	151.86	142.72	144.61	-0.0429634657146832	7.15464879495918	0.51111625223323	0.830321428997656	12:57747726-57756013:-	CDK4	63;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0000785,cellular_component chromatin;GO:0002088,biological_process lens development in camera-type eye;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005923,cellular_component bicellular tight junction;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007623,biological_process circadian rhythm;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009636,biological_process response to toxic substance;GO:0010033,biological_process response to organic substance;GO:0010288,biological_process response to lead ion;GO:0010468,biological_process regulation of gene expression;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0016740,molecular_function transferase activity;GO:0030332,molecular_function cyclin binding;GO:0031100,biological_process organ regeneration;GO:0031965,cellular_component nuclear membrane;GO:0032403,molecular_function protein complex binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033574,biological_process response to testosterone;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045727,biological_process positive regulation of translation;GO:0045787,biological_process positive regulation of cell cycle;GO:0045793,biological_process positive regulation of cell size;GO:0045859,biological_process regulation of protein kinase activity;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0046890,biological_process regulation of lipid biosynthetic process;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050994,biological_process regulation of lipid catabolic process;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle;GO:0055093,biological_process response to hyperoxia;GO:0060612,biological_process adipose tissue development;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071353,biological_process cellular response to interleukin-4;GO:0097129,cellular_component cyclin D2-CDK4 complex;GO:1904628,biological_process cellular response to phorbol 13-acetate 12-myristate;GO:1904637,biological_process cellular response to ionomycin	CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]; K02089	cyclin dependent kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:1773]
ENSG00000174851	60.78	58.63	59.38	59.14	58.47	57.57	0.0423790531961595	5.89298932227808	0.511643190801794	0.830977292874175	11:66284579-66289170:-	YIF1A	15;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030173,cellular_component integral component of Golgi membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response	NA	Yip1 interacting factor homolog A%2C membrane trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:16688]
ENSG00000141030	42.96	43.25	42.48	47.11	43.44	43.18	-0.0440283176587427	5.92095549739619	0.51165386686839	0.830977292874175	17:17246819-17281293:-	COPS3	14;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0001701,biological_process in utero embryonic development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007165,biological_process signal transduction;GO:0008180,cellular_component COP9 signalosome;GO:0009416,biological_process response to light stimulus;GO:0043687,biological_process post-translational protein modification	NA	COP9 signalosome subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:2239]
ENSG00000160201	1.70	2.30	2.33	2.27	1.34	1.87	0.201530510778379	0.763872806205406	0.511896745190763	0.831262990326131	21:43092955-43107587:-	U2AF1	21;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0030628,molecular_function pre-mRNA 3'-splice site binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0046872,molecular_function metal ion binding;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0089701,cellular_component U2AF;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	U2AF1; splicing factor U2AF 35 kDa subunit; K12836	U2 small nuclear RNA auxiliary factor 1 [Source:HGNC Symbol%3BAcc:HGNC:12453]
ENSG00000111875	52.97	49.81	47.50	53.58	51.68	51.82	-0.0509967039951056	4.97896800593574	0.51207811446445	0.831419590887588	6:118894219-118909167:+	ASF1A	18;GO:0000790,cellular_component nuclear chromatin;GO:0001649,biological_process osteoblast differentiation;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006333,biological_process chromatin assembly or disassembly;GO:0006334,biological_process nucleosome assembly;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0031936,biological_process negative regulation of chromatin silencing;GO:0042393,molecular_function histone binding;GO:0042692,biological_process muscle cell differentiation;GO:0043234,cellular_component protein complex	NA	anti-silencing function 1A histone chaperone [Source:HGNC Symbol%3BAcc:HGNC:20995]
ENSG00000108349	26.66	25.24	26.04	25.78	26.01	24.53	0.0444926879883732	5.82414035169986	0.512153070919031	0.831419590887588	17:40140317-40172183:+	CASC3	27;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0008298,biological_process intracellular mRNA localization;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0019899,molecular_function enzyme binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031124,biological_process mRNA 3'-end processing;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031965,cellular_component nuclear membrane;GO:0035145,cellular_component exon-exon junction complex;GO:0042802,molecular_function identical protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051028,biological_process mRNA transport	CASC3, MLN51; protein CASC3; K14323	cancer susceptibility 3 [Source:HGNC Symbol%3BAcc:HGNC:17040]
ENSG00000172831	40.80	36.37	42.04	43.98	39.23	41.20	-0.0470977342760592	6.32538302897489	0.512194119996567	0.831419590887588	16:66934443-66945096:+	CES2	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006693,biological_process prostaglandin metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0009056,biological_process catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0047374,molecular_function methylumbelliferyl-acetate deacetylase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity	CES2; carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]; K03927	carboxylesterase 2 [Source:HGNC Symbol%3BAcc:HGNC:1864]
ENSG00000160993	8.57	9.60	8.20	9.83	8.20	6.52	0.111300105543359	2.96422579270592	0.512433993381364	0.831572261223338	7:102456237-102464876:-	ALKBH4	18;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006482,biological_process protein demethylation;GO:0016491,molecular_function oxidoreductase activity;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0030496,cellular_component midbody;GO:0031032,biological_process actomyosin structure organization;GO:0032451,molecular_function demethylase activity;GO:0036090,biological_process cleavage furrow ingression;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070938,cellular_component contractile ring;GO:0070988,biological_process demethylation	NA	alkB homolog 4%2C lysine demethylase [Source:HGNC Symbol%3BAcc:HGNC:21900]
ENSG00000147804	7.72	6.73	7.12	7.42	5.82	7.38	0.0797677935841292	3.8742352226171	0.512484147407276	0.831572261223338	8:144409741-144416895:-	SLC39A4	20;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030001,biological_process metal ion transport;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034224,biological_process cellular response to zinc ion starvation;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0055038,cellular_component recycling endosome membrane;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071578,biological_process zinc II ion transmembrane import	SLC39A4, ZIP4; solute carrier family 39 (zinc transporter), member 4; K14710	solute carrier family 39 member 4 [Source:HGNC Symbol%3BAcc:HGNC:17129]
ENSG00000153006	11.85	10.07	12.19	9.18	11.58	11.04	0.123161989502205	2.40030076997249	0.512489148341137	0.831572261223338	5:64718143-64768685:-	SREK1IP1	6;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0046872,molecular_function metal ion binding	NA	SREK1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26716]
ENSG00000260916	22.96	17.53	22.18	22.59	19.84	23.68	-0.0612266553515822	5.84427458639267	0.512712301271632	0.831617718596361	15:55340031-55408510:-	CCPG1	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045787,biological_process positive regulation of cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:2001106,biological_process regulation of Rho guanyl-nucleotide exchange factor activity	NA	cell cycle progression 1 [Source:HGNC Symbol%3BAcc:HGNC:24227]
ENSG00000011485	33.31	38.28	35.64	37.58	39.67	34.65	-0.0526249669296959	5.79607160683923	0.512715026028956	0.831617718596361	19:46346993-46392981:+	PPP5C	46;GO:0000165,biological_process MAPK cascade;GO:0000278,biological_process mitotic cell cycle;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0003723,molecular_function RNA binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006470,biological_process protein dephosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008017,molecular_function microtubule binding;GO:0008289,molecular_function lipid binding;GO:0010288,biological_process response to lead ion;GO:0016020,cellular_component membrane;GO:0016576,biological_process histone dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0031072,molecular_function heat shock protein binding;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043204,cellular_component perikaryon;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043278,biological_process response to morphine;GO:0043531,molecular_function ADP binding;GO:0046872,molecular_function metal ion binding;GO:0051259,biological_process protein oligomerization;GO:0051291,biological_process protein heterooligomerization;GO:0051879,molecular_function Hsp90 protein binding;GO:0060548,biological_process negative regulation of cell death;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071276,biological_process cellular response to cadmium ion;GO:0071944,cellular_component cell periphery;GO:1901215,biological_process negative regulation of neuron death;GO:1990635,cellular_component proximal dendrite;GO:2000324,biological_process positive regulation of glucocorticoid receptor signaling pathway	PPP5C; serine/threonine-protein phosphatase 5 [EC:3.1.3.16]; K04460	protein phosphatase 5 catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9322]
ENSG00000128654	73.17	73.01	79.08	76.53	76.11	81.60	-0.0439704881498567	6.04628764420828	0.512764518211712	0.831617718596361	2:176269394-176338025:+	MTX2	9;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane	NA	metaxin 2 [Source:HGNC Symbol%3BAcc:HGNC:7506]
ENSG00000107738	3.29	4.85	3.14	3.34	3.54	3.35	0.125451283001524	1.86452542155964	0.512785146067554	0.831617718596361	10:71747558-71773498:-	VSIR	3;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	V-set immunoregulatory receptor [Source:HGNC Symbol%3BAcc:HGNC:30085]
ENSG00000077157	2.05	2.58	2.24	2.39	1.87	2.18	0.0920493731776778	2.97082593292398	0.51288568197851	0.831656059012699	1:202348698-202592706:+	PPP1R12B	12;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006937,biological_process regulation of muscle contraction;GO:0007165,biological_process signal transduction;GO:0008047,molecular_function enzyme activator activity;GO:0019901,molecular_function protein kinase binding;GO:0030018,cellular_component Z disc;GO:0031672,cellular_component A band;GO:0043085,biological_process positive regulation of catalytic activity	PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B; K12329	protein phosphatase 1 regulatory subunit 12B [Source:HGNC Symbol%3BAcc:HGNC:7619]
ENSG00000100027	3.80	9.76	6.92	7.65	7.14	8.51	-0.209639870383796	1.50008188206911	0.51294278480635	0.831656059012699	22:21697543-21735834:-	YPEL1	2;GO:0005634,cellular_component nucleus;GO:0046872,molecular_function metal ion binding	NA	yippee like 1 [Source:HGNC Symbol%3BAcc:HGNC:12845]
ENSG00000104325	85.66	89.30	80.33	86.62	90.49	88.08	-0.0445881531175958	6.6554227196121	0.513112413418341	0.831822435387471	8:90001404-90052092:+	DECR1	15;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008670,molecular_function 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070402,molecular_function NADPH binding	NA	2%2C4-dienoyl-CoA reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:2753]
ENSG00000131019	6.17	4.18	3.22	4.60	6.11	4.71	-0.161833376126244	1.89102368941698	0.513196003003885	0.831849305992064	6:150063149-150069095:-	ULBP3	9;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0030101,biological_process natural killer cell activation;GO:0031225,cellular_component anchored component of membrane;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0046658,cellular_component anchored component of plasma membrane;GO:0046703,molecular_function natural killer cell lectin-like receptor binding;GO:0050776,biological_process regulation of immune response	ULBP; UL16 binding protein; K07986	UL16 binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:14895]
ENSG00000212719	11.66	10.35	12.83	12.76	10.12	14.96	-0.102804714519657	3.22956658700746	0.513365546934469	0.832015476445693	17:21524789-21574458:-	C17orf51	NA	NA	chromosome 17 open reading frame 51 [Source:HGNC Symbol%3BAcc:HGNC:27904]
ENSG00000198160	31.25	31.56	33.49	30.01	30.68	33.40	0.0451626161051792	5.87563683613543	0.51346959625434	0.832075469752627	1:66924894-66988619:+	MIER1	16;GO:0003677,molecular_function DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0016575,biological_process histone deacetylation;GO:0017053,cellular_component transcriptional repressor complex;GO:0031937,biological_process positive regulation of chromatin silencing;GO:0042826,molecular_function histone deacetylase binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex	NA	MIER1 transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:29657]
ENSG00000138356	1.02	0.98	0.68	0.99	0.83	1.15	-0.146243218869586	2.00519449420241	0.513815092519487	0.832419505988489	2:200585867-200677064:+	AOX1	24;GO:0003824,molecular_function catalytic activity;GO:0004031,molecular_function aldehyde oxidase activity;GO:0005506,molecular_function iron ion binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009055,molecular_function electron carrier activity;GO:0009115,biological_process xanthine catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016604,cellular_component nuclear body;GO:0016614,molecular_function oxidoreductase activity, acting on CH-OH group of donors;GO:0016903,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors;GO:0017144,biological_process drug metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0042816,biological_process vitamin B6 metabolic process;GO:0043546,molecular_function molybdopterin cofactor binding;GO:0046872,molecular_function metal ion binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051287,molecular_function NAD binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0102797,molecular_function geranial:oxygen oxidoreductase activity;GO:0102798,molecular_function heptaldehyde:oxygen oxidoreductase activity	AOX; aldehyde oxidase [EC:1.2.3.1]; K00157	aldehyde oxidase 1 [Source:HGNC Symbol%3BAcc:HGNC:553]
ENSG00000234545	35.45	34.39	29.81	31.62	33.34	31.38	0.0593339106530233	4.62863834991471	0.513854907155519	0.832419505988489	7:92560792-92590394:-	FAM133B	1;GO:0003723,molecular_function RNA binding	NA	family with sequence similarity 133 member B [Source:HGNC Symbol%3BAcc:HGNC:28629]
ENSG00000156374	7.00	7.01	6.31	8.06	6.86	6.90	-0.093342761550763	2.91177106351982	0.513902557916722	0.832419505988489	10:103302795-103351134:-	PCGF6	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	PCGF6, MBLR; polycomb group RING finger protein 6; K11470	polycomb group ring finger 6 [Source:HGNC Symbol%3BAcc:HGNC:21156]
ENSG00000141527	0.54	0.32	0.42	0.47	0.28	0.35	0.248521499310602	0.438105604661117	0.513951966669524	0.832419505988489	17:80169991-80209331:+	CARD14	10;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0050700,molecular_function CARD domain binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	NA	caspase recruitment domain family member 14 [Source:HGNC Symbol%3BAcc:HGNC:16446]
ENSG00000232434	2.48	2.64	3.12	2.53	2.77	3.67	-0.1124533250699	3.10274456952145	0.514142520271437	0.832419505988489	9:136844414-136848801:+	C9orf172	NA	NA	chromosome 9 open reading frame 172 [Source:HGNC Symbol%3BAcc:HGNC:37284]
ENSG00000243566	1.15	0.46	1.70	1.51	0.95	1.56	-0.219121283898519	0.541074934175198	0.514144989356269	0.832419505988489	7:76510427-76516521:+	UPK3B	5;GO:0005886,cellular_component plasma membrane;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	uroplakin 3B [Source:HGNC Symbol%3BAcc:HGNC:21444]
ENSG00000149806	397.88	401.19	378.21	385.85	371.70	396.15	0.0403298694667466	7.29632153517119	0.514217358817136	0.832419505988489	11:65120627-65122473:-	FAU	22;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002227,biological_process innate immune response in mucosa;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005575,cellular_component cellular_component;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008150,biological_process biological_process;GO:0015935,cellular_component small ribosomal subunit;GO:0019083,biological_process viral transcription;GO:0019731,biological_process antibacterial humoral response;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide	RP-S30e, RPS30; small subunit ribosomal protein S30e; K02983	FAU%2C ubiquitin like and ribosomal protein S30 fusion [Source:HGNC Symbol%3BAcc:HGNC:3597]
ENSG00000179364	26.80	25.55	27.65	26.42	24.78	27.10	0.0442220104853248	6.16549782793446	0.514218381690142	0.832419505988489	14:105300562-105398147:+	PACS2	8;GO:0000045,biological_process autophagosome assembly;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0006915,biological_process apoptotic process;GO:0016032,biological_process viral process;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0044325,molecular_function ion channel binding;GO:0072661,biological_process protein targeting to plasma membrane	NA	phosphofurin acidic cluster sorting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:23794]
ENSG00000140455	32.70	33.09	31.86	33.64	29.71	32.02	0.0447515731899898	5.87981853268329	0.514322432821983	0.83243970959451	15:63504510-63594640:+	USP3	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000278,biological_process mitotic cell cycle;GO:0000790,cellular_component nuclear chromatin;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0031647,biological_process regulation of protein stability;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding;GO:0070938,cellular_component contractile ring	NA	ubiquitin specific peptidase 3 [Source:HGNC Symbol%3BAcc:HGNC:12626]
ENSG00000103549	28.77	29.09	27.88	30.38	29.34	29.24	-0.042087597946904	6.50147980464566	0.514364986110521	0.83243970959451	16:30761744-30776307:+	RNF40	30;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0010390,biological_process histone monoubiquitination;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0017075,molecular_function syntaxin-1 binding;GO:0019898,cellular_component extrinsic component of membrane;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0033503,cellular_component HULC complex;GO:0033523,biological_process histone H2B ubiquitination;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0043679,cellular_component axon terminus;GO:0046872,molecular_function metal ion binding;GO:1900364,biological_process negative regulation of mRNA polyadenylation;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902916,biological_process positive regulation of protein polyubiquitination;GO:2001168,biological_process positive regulation of histone H2B ubiquitination	NA	ring finger protein 40 [Source:HGNC Symbol%3BAcc:HGNC:16867]
ENSG00000171450	1.60	1.39	1.60	1.56	1.52	0.96	0.215332514047333	0.795459277366167	0.514493448412932	0.832539065982236	2:218959654-218962162:+	CDK5R2	15;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001764,biological_process neuron migration;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016533,cellular_component cyclin-dependent protein kinase 5 holoenzyme complex;GO:0016534,molecular_function cyclin-dependent protein kinase 5 activator activity;GO:0021549,biological_process cerebellum development;GO:0021722,biological_process superior olivary nucleus maturation;GO:0021766,biological_process hippocampus development;GO:0021819,biological_process layer formation in cerebral cortex;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity	NA	cyclin dependent kinase 5 regulatory subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:1776]
ENSG00000112137	2.54	3.20	2.81	3.28	2.70	3.21	-0.10377580630952	3.03151010027142	0.514740205069607	0.832829792170104	6:12716804-13290484:+	PHACTR1	15;GO:0003779,molecular_function actin binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030054,cellular_component cell junction;GO:0031032,biological_process actomyosin structure organization;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043149,biological_process stress fiber assembly;GO:0045202,cellular_component synapse;GO:0048870,biological_process cell motility;GO:0050790,biological_process regulation of catalytic activity	NA	phosphatase and actin regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:20990]
ENSG00000158941	18.65	20.20	19.22	18.13	19.72	18.86	0.0434169071728656	5.82543965488053	0.515044481291574	0.832993558626285	8:22604631-22621514:+	CCAR2	36;GO:0000790,cellular_component nuclear chromatin;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003723,molecular_function RNA binding;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008380,biological_process RNA splicing;GO:0009411,biological_process response to UV;GO:0016055,biological_process Wnt signaling pathway;GO:0019899,molecular_function enzyme binding;GO:0030308,biological_process negative regulation of cell growth;GO:0031647,biological_process regulation of protein stability;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0042752,biological_process regulation of circadian rhythm;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0044609,cellular_component DBIRD complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0090311,biological_process regulation of protein deacetylation;GO:1900034,biological_process regulation of cellular response to heat;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2000003,biological_process positive regulation of DNA damage checkpoint	NA	cell cycle and apoptosis regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:23360]
ENSG00000096092	100.83	120.66	99.87	103.61	111.08	94.94	0.0596389052156113	4.96812029585711	0.515142105581594	0.832993558626285	6:52671108-52686588:+	TMEM14A	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 14A [Source:HGNC Symbol%3BAcc:HGNC:21076]
ENSG00000138686	13.32	13.04	12.65	11.26	12.86	13.66	0.0570078797835575	4.789104342677	0.515196969667906	0.832993558626285	4:121824439-121870497:-	BBS7	40;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001654,biological_process eye development;GO:0001750,cellular_component photoreceptor outer segment;GO:0001947,biological_process heart looping;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0007224,biological_process smoothened signaling pathway;GO:0007368,biological_process determination of left/right symmetry;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007601,biological_process visual perception;GO:0008104,biological_process protein localization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0032402,biological_process melanosome transport;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034464,cellular_component BBSome;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045444,biological_process fat cell differentiation;GO:0046907,biological_process intracellular transport;GO:0048546,biological_process digestive tract morphogenesis;GO:0050896,biological_process response to stimulus;GO:0051877,biological_process pigment granule aggregation in cell center;GO:0060021,biological_process palate development;GO:0060170,cellular_component ciliary membrane;GO:0060173,biological_process limb development;GO:0060271,biological_process cilium morphogenesis;GO:1905515,biological_process non-motile cilium assembly	NA	Bardet-Biedl syndrome 7 [Source:HGNC Symbol%3BAcc:HGNC:18758]
ENSG00000137502	1.55	2.24	1.29	2.19	1.89	1.85	-0.243592664048076	0.479224786736087	0.51523070463388	0.832993558626285	11:82973132-83071923:-	RAB30	13;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0031985,cellular_component Golgi cisterna;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	RAB30%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9770]
ENSG00000115685	52.20	51.36	51.19	55.22	52.75	52.63	-0.0414748522581038	6.08080790613237	0.515318695080394	0.832993558626285	2:241149575-241183652:+	PPP1R7	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0007059,biological_process chromosome segregation;GO:0008150,biological_process biological_process;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030234,molecular_function enzyme regulator activity;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0050790,biological_process regulation of catalytic activity;GO:0061588,biological_process calcium activated phospholipid scrambling;GO:0070062,cellular_component extracellular exosome	NA	protein phosphatase 1 regulatory subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:9295]
ENSG00000145107	2.97	2.57	3.73	3.87	2.21	4.55	-0.178780753035494	1.70662475316648	0.515338820935477	0.832993558626285	3:196319341-196338503:-	TM4SF19	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane 4 L six family member 19 [Source:HGNC Symbol%3BAcc:HGNC:25167]
ENSG00000259305	2.58	1.42	1.93	2.31	1.90	2.65	-0.170641514192425	1.03549877892167	0.515410786082448	0.832993558626285	8:123226188-123274284:-	ZHX1-C8orf76	NA	NA	ZHX1-C8orf76 readthrough [Source:HGNC Symbol%3BAcc:HGNC:42975]
ENSG00000253304	4.60	4.36	5.11	4.47	3.87	4.73	0.121476428085364	2.11461536329534	0.515420799909112	0.832993558626285	1:29119427-29123935:-	TMEM200B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 200B [Source:HGNC Symbol%3BAcc:HGNC:33785]
ENSG00000197980	0.53	0.38	0.87	0.69	0.70	0.74	-0.217108550586706	0.729579696955547	0.515445381761741	0.832993558626285	3:156825480-157046129:+	LEKR1	NA	NA	leucine%2C glutamate and lysine rich 1 [Source:HGNC Symbol%3BAcc:HGNC:33765]
ENSG00000145833	26.34	32.20	26.62	24.15	32.19	25.48	0.0680014662747991	6.43647495255433	0.515622255663306	0.833054389358159	5:134758770-134855133:+	DDX46	20;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010468,biological_process regulation of gene expression;GO:0010501,biological_process RNA secondary structure unwinding;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity	DDX46, PRP5; ATP-dependent RNA helicase DDX46/PRP5 [EC:3.6.4.13]; K12811	DEAD-box helicase 46 [Source:HGNC Symbol%3BAcc:HGNC:18681]
ENSG00000163812	22.72	20.93	23.12	23.73	23.05	23.01	-0.0472317575158565	5.06469934025782	0.515663400232318	0.833054389358159	3:44915256-44976185:-	ZDHHC3	10;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006605,biological_process protein targeting;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:18470]
ENSG00000140948	7.33	8.13	7.36	7.18	8.83	8.02	-0.0668962748788978	4.52858946486298	0.515684357353427	0.833054389358159	16:87406245-87492045:-	ZCCHC14	4;GO:0003676,molecular_function nucleic acid binding;GO:0008270,molecular_function zinc ion binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 14 [Source:HGNC Symbol%3BAcc:HGNC:24134]
ENSG00000140545	87.65	83.93	86.41	80.64	84.20	87.85	0.0422685348489664	6.68607621863832	0.515809593664818	0.833148274061339	15:88898682-88913411:-	MFGE8	22;GO:0001525,biological_process angiogenesis;GO:0001786,molecular_function phosphatidylserine binding;GO:0005178,molecular_function integrin binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006910,biological_process phagocytosis, recognition;GO:0006911,biological_process phagocytosis, engulfment;GO:0007155,biological_process cell adhesion;GO:0007338,biological_process single fertilization;GO:0008429,molecular_function phosphatidylethanolamine binding;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0031012,cellular_component extracellular matrix;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0050766,biological_process positive regulation of phagocytosis;GO:0070062,cellular_component extracellular exosome;GO:1903561,cellular_component extracellular vesicle;GO:2000427,biological_process positive regulation of apoptotic cell clearance	NA	milk fat globule-EGF factor 8 protein [Source:HGNC Symbol%3BAcc:HGNC:7036]
ENSG00000269313	0.95	0.43	0.73	0.67	1.22	0.69	-0.234250469841271	0.0541308508268211	0.515954116095703	0.833273281693464	X:49162563-49168483:+	MAGIX	NA	NA	MAGI family member%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:30006]
ENSG00000169814	33.82	31.84	30.11	30.99	31.58	31.11	0.0441567897021966	5.92713868636453	0.516131611109954	0.833354521752666	3:15601340-15645822:+	BTD	11;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005759,cellular_component mitochondrial matrix;GO:0006768,biological_process biotin metabolic process;GO:0006807,biological_process nitrogen compound metabolic process;GO:0007417,biological_process central nervous system development;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016811,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0047708,molecular_function biotinidase activity;GO:0070062,cellular_component extracellular exosome	BTD; biotinidase [EC:3.5.1.12]; K01435	biotinidase [Source:HGNC Symbol%3BAcc:HGNC:1122]
ENSG00000149300	3.45	4.14	3.79	3.25	3.49	3.05	0.217719404897316	0.530656949553992	0.516182645471989	0.833354521752666	11:111918031-111926872:+	C11orf52	1;GO:0070062,cellular_component extracellular exosome	NA	chromosome 11 open reading frame 52 [Source:HGNC Symbol%3BAcc:HGNC:30531]
ENSG00000161682	2.98	3.65	3.28	3.04	3.59	2.66	0.0989557882912222	3.02648053556684	0.51626483887248	0.833354521752666	17:44353214-44363875:-	FAM171A2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 171 member A2 [Source:HGNC Symbol%3BAcc:HGNC:30480]
ENSG00000156603	29.44	30.21	29.38	33.95	30.66	28.87	-0.0589256767816132	4.60344102244874	0.516286523946181	0.833354521752666	11:57703713-57712323:-	MED19	10;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0016592,cellular_component mediator complex;GO:0016604,cellular_component nuclear body;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	mediator complex subunit 19 [Source:HGNC Symbol%3BAcc:HGNC:29600]
ENSG00000132128	35.98	36.28	35.11	37.13	34.49	33.40	0.0434469009445733	6.71294174618873	0.51639722677742	0.833354521752666	1:46261195-46303608:-	LRRC41	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0042803,molecular_function protein homodimerization activity;GO:0043687,biological_process post-translational protein modification	NA	leucine rich repeat containing 41 [Source:HGNC Symbol%3BAcc:HGNC:16917]
ENSG00000169905	10.07	10.65	11.84	11.71	11.02	11.54	-0.0622396811773159	4.34058023395162	0.516407232846331	0.833354521752666	1:179839966-179877803:-	TOR1AIP2	12;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007029,biological_process endoplasmic reticulum organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0032781,biological_process positive regulation of ATPase activity;GO:0051117,molecular_function ATPase binding;GO:0090435,biological_process protein localization to nuclear envelope	NA	torsin 1A interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:24055]
ENSG00000023171	1.62	2.53	1.99	1.93	2.01	1.72	0.111108724402849	2.64637849256657	0.516516892150036	0.833423135611387	11:123358427-123627774:+	GRAMD1B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	GRAM domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:29214]
ENSG00000164039	24.48	26.74	23.53	21.91	28.23	21.12	0.0781054207785585	4.25248018635792	0.516638903073516	0.833511658935735	4:103079434-103099883:-	BDH2	15;GO:0003858,molecular_function 3-hydroxybutyrate dehydrogenase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008667,molecular_function 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016628,molecular_function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0019290,biological_process siderophore biosynthetic process;GO:0030855,biological_process epithelial cell differentiation;GO:0042168,biological_process heme metabolic process;GO:0046951,biological_process ketone body biosynthetic process;GO:0051287,molecular_function NAD binding;GO:0055072,biological_process iron ion homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	E1.1.1.30, bdh; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]; K00019	3-hydroxybutyrate dehydrogenase 2 [Source:HGNC Symbol%3BAcc:HGNC:32389]
ENSG00000145014	31.50	29.99	31.75	32.94	26.81	30.94	0.053012101024891	5.65865100854029	0.516970963648719	0.833797377176057	3:194587672-194633689:-	TMEM44	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 44 [Source:HGNC Symbol%3BAcc:HGNC:25120]
ENSG00000159199	99.29	121.97	81.88	94.28	107.92	86.48	0.0779695199897112	5.33428567786195	0.5169806566515	0.833797377176057	17:48892764-48895871:+	ATP5G1	22;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008289,molecular_function lipid binding;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0033177,cellular_component proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism	ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c; K02128	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit C1 (subunit 9) [Source:HGNC Symbol%3BAcc:HGNC:841]
ENSG00000156873	19.52	20.51	16.43	17.59	18.00	18.78	0.0603866100660223	4.56691568877197	0.517017514873448	0.833797377176057	16:30748269-30761176:+	PHKG2	25;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004689,molecular_function phosphorylase kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0005964,cellular_component phosphorylase kinase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0005980,biological_process glycogen catabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0035556,biological_process intracellular signal transduction;GO:0045819,biological_process positive regulation of glycogen catabolic process;GO:0050321,molecular_function tau-protein kinase activity	PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]; K00871	phosphorylase kinase catalytic subunit gamma 2 [Source:HGNC Symbol%3BAcc:HGNC:8931]
ENSG00000168476	15.33	15.27	15.98	16.17	16.63	16.40	-0.065889616375799	3.90248922522437	0.517147916812342	0.833820310097216	8:22138019-22141951:-	REEP4	10;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005874,cellular_component microtubule;GO:0006998,biological_process nuclear envelope organization;GO:0007049,biological_process cell cycle;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051301,biological_process cell division	NA	receptor accessory protein 4 [Source:HGNC Symbol%3BAcc:HGNC:26176]
ENSG00000067596	16.03	15.88	15.25	15.50	17.57	16.00	-0.0453585689190835	5.95108368533497	0.517332355295161	0.833820310097216	17:43483864-43544463:+	DHX8	19;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0071013,cellular_component catalytic step 2 spliceosome	DHX8, PRP22; ATP-dependent RNA helicase DHX8/PRP22 [EC:3.6.4.13]; K12818	DEAH-box helicase 8 [Source:HGNC Symbol%3BAcc:HGNC:2749]
ENSG00000120742	136.09	139.86	138.32	137.86	136.03	130.81	0.0448144815729434	5.43138518975639	0.517397812811842	0.833820310097216	3:150541993-150603228:-	SERP1	25;GO:0001501,biological_process skeletal system development;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006006,biological_process glucose metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0006810,biological_process transport;GO:0006950,biological_process response to stress;GO:0007009,biological_process plasma membrane organization;GO:0009791,biological_process post-embryonic development;GO:0010259,biological_process multicellular organism aging;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032024,biological_process positive regulation of insulin secretion;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0045727,biological_process positive regulation of translation;GO:0046622,biological_process positive regulation of organ growth;GO:0048644,biological_process muscle organ morphogenesis;GO:0060124,biological_process positive regulation of growth hormone secretion	NA	stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10759]
ENSG00000171467	22.32	21.76	21.48	21.09	20.76	22.42	0.040240056400819	7.22704301252184	0.517503787869337	0.833820310097216	6:43307133-43369478:-	ZNF318	9;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:0051321,biological_process meiotic cell cycle	NA	zinc finger protein 318 [Source:HGNC Symbol%3BAcc:HGNC:13578]
ENSG00000163093	1.38	1.21	1.37	1.54	0.89	0.96	0.24655995264912	0.491692038723559	0.517593546059048	0.833820310097216	2:169479177-169506655:+	BBS5	26;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001947,biological_process heart looping;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006810,biological_process transport;GO:0007601,biological_process visual perception;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0032402,biological_process melanosome transport;GO:0034464,cellular_component BBSome;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0046907,biological_process intracellular transport;GO:0050896,biological_process response to stimulus;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis	NA	Bardet-Biedl syndrome 5 [Source:HGNC Symbol%3BAcc:HGNC:970]
ENSG00000105137	13.94	12.91	12.63	12.53	12.92	13.00	0.0518186616752698	4.9285807947328	0.517679497230172	0.833820310097216	19:15107402-15114988:+	SYDE1	9;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0090630,biological_process activation of GTPase activity;GO:1901165,biological_process positive regulation of trophoblast cell migration	NA	synapse defective Rho GTPase homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:25824]
ENSG00000115365	35.28	36.69	38.13	38.73	37.40	38.35	-0.0450367885957149	5.54806370184062	0.517719726469342	0.833820310097216	2:210431248-210477652:-	LANCL1	13;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0043295,molecular_function glutathione binding;GO:0046872,molecular_function metal ion binding;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0070062,cellular_component extracellular exosome	NA	LanC like 1 [Source:HGNC Symbol%3BAcc:HGNC:6508]
ENSG00000162729	30.61	27.18	29.86	30.49	28.87	32.00	-0.0451722046006652	5.78462968238877	0.51772239210938	0.833820310097216	1:160091339-160098943:-	IGSF8	10;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0007338,biological_process single fertilization;GO:0007399,biological_process nervous system development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	immunoglobulin superfamily member 8 [Source:HGNC Symbol%3BAcc:HGNC:17813]
ENSG00000164542	8.14	8.22	9.16	8.05	7.89	8.65	0.066709925517898	4.04222794296737	0.517782045840416	0.833820310097216	7:36324220-36390125:-	KIAA0895	NA	NA	KIAA0895 [Source:HGNC Symbol%3BAcc:HGNC:22206]
ENSG00000167487	3.37	3.39	3.40	3.61	2.88	3.08	0.099258252566152	2.78783383369886	0.517800541439912	0.833820310097216	19:18636964-18671714:+	KLHL26	7;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0007286,biological_process spermatid development;GO:0008584,biological_process male gonad development;GO:0009566,biological_process fertilization;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch like family member 26 [Source:HGNC Symbol%3BAcc:HGNC:25623]
ENSG00000138336	0.28	0.30	0.39	0.26	0.43	0.42	-0.175382143946473	1.24359773857248	0.517840563442612	0.833820310097216	10:68560655-68694482:+	TET1	20;GO:0001826,biological_process inner cell mass cell differentiation;GO:0003677,molecular_function DNA binding;GO:0005506,molecular_function iron ion binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006493,biological_process protein O-linked glycosylation;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0019827,biological_process stem cell population maintenance;GO:0031062,biological_process positive regulation of histone methylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070579,molecular_function methylcytosine dioxygenase activity;GO:0080111,biological_process DNA demethylation;GO:0090310,biological_process negative regulation of methylation-dependent chromatin silencing	NA	tet methylcytosine dioxygenase 1 [Source:HGNC Symbol%3BAcc:HGNC:29484]
ENSG00000140995	15.70	16.03	16.71	17.90	16.95	15.88	-0.0537709051664314	4.79485833363026	0.517847221916889	0.833820310097216	16:89947924-89968060:+	DEF8	3;GO:0005622,cellular_component intracellular;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	differentially expressed in FDCP 8 homolog [Source:HGNC Symbol%3BAcc:HGNC:25969]
ENSG00000175318	0.62	0.92	0.65	0.72	1.20	0.80	-0.326517420462441	0.107051871667966	0.517909929678396	0.833820310097216	15:72159806-72197785:-	GRAMD2A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	GRAM domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:27287]
ENSG00000205413	5.32	6.38	4.74	5.48	6.62	5.33	-0.0785978554639479	4.75349896858052	0.518090320598398	0.833820310097216	7:93099512-93118023:-	SAMD9	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0034058,biological_process endosomal vesicle fusion;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	sterile alpha motif domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:1348]
ENSG00000147231	2.96	2.80	2.35	2.00	3.35	2.12	0.133073752220495	2.83310861563931	0.518151740533015	0.833820310097216	X:106611929-106679442:+	CXorf57	2;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding	NA	chromosome X open reading frame 57 [Source:HGNC Symbol%3BAcc:HGNC:25486]
ENSG00000117592	308.15	319.41	288.60	303.39	290.96	303.04	0.0408323546504923	7.66786734414271	0.518185637352211	0.833820310097216	1:173477265-173488807:+	PRDX6	37;GO:0003824,molecular_function catalytic activity;GO:0004601,molecular_function peroxidase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034599,biological_process cellular response to oxidative stress;GO:0035578,cellular_component azurophil granule lumen;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0045296,molecular_function cadherin binding;GO:0045454,biological_process cell redox homeostasis;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0047499,molecular_function calcium-independent phospholipase A2 activity;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051920,molecular_function peroxiredoxin activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	NA	peroxiredoxin 6 [Source:HGNC Symbol%3BAcc:HGNC:16753]
ENSG00000160360	6.93	6.50	6.76	6.75	6.29	6.46	0.0662221734960972	3.97534525847218	0.518258519053276	0.833820310097216	9:136327475-136359605:+	GPSM1	18;GO:0000139,cellular_component Golgi membrane;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0030695,molecular_function GTPase regulator activity;GO:0043234,cellular_component protein complex;GO:0050790,biological_process regulation of catalytic activity	GPSM1, AGS3; G-protein signaling modulator 1; K15839	G protein signaling modulator 1 [Source:HGNC Symbol%3BAcc:HGNC:17858]
ENSG00000127922	74.74	74.84	72.08	77.61	75.84	76.33	-0.0407697224086387	6.32786189456658	0.518315869851195	0.833820310097216	7:96481625-96709891:-	SEM1	32;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006406,biological_process mRNA export from nucleus;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0032039,cellular_component integrator complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043248,biological_process proteasome assembly;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	SHFM1, DSS1; 26 proteasome complex subunit DSS1; K10881	SEM1%2C 26S proteasome complex subunit [Source:HGNC Symbol%3BAcc:HGNC:10845]
ENSG00000100554	80.95	87.88	87.81	82.50	85.20	83.33	0.0419328968960897	5.9835329790138	0.518586512939296	0.833820310097216	14:67294370-67360265:-	ATP6V1D	24;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0030030,biological_process cell projection organization;GO:0033176,cellular_component proton-transporting V-type ATPase complex;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0035579,cellular_component specific granule membrane;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043312,biological_process neutrophil degranulation;GO:0055085,biological_process transmembrane transport;GO:0060271,biological_process cilium morphogenesis;GO:0061512,biological_process protein localization to cilium;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV1D, ATP6M; V-type H+-transporting ATPase subunit D; K02149	ATPase H+ transporting V1 subunit D [Source:HGNC Symbol%3BAcc:HGNC:13527]
ENSG00000134121	0.43	0.56	0.26	0.30	0.69	0.46	-0.23564611347444	0.936557994368188	0.518651243099693	0.833820310097216	3:196595-409417:+	CHL1	22;GO:0001764,biological_process neuron migration;GO:0002020,molecular_function protease binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0008344,biological_process adult locomotory behavior;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0031103,biological_process axon regeneration;GO:0031175,biological_process neuron projection development;GO:0035640,biological_process exploration behavior;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045177,cellular_component apical part of cell;GO:0050890,biological_process cognition;GO:0070062,cellular_component extracellular exosome	NA	cell adhesion molecule L1 like [Source:HGNC Symbol%3BAcc:HGNC:1939]
ENSG00000215717	76.67	72.32	81.56	77.23	72.43	73.17	0.0659151103524839	4.0835272774099	0.51870347904465	0.833820310097216	1:109089802-109096934:+	TMEM167B	7;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0009306,biological_process protein secretion;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046907,biological_process intracellular transport	NA	transmembrane protein 167B [Source:HGNC Symbol%3BAcc:HGNC:30187]
ENSG00000205250	21.62	21.87	23.76	22.43	23.71	24.14	-0.0509113545913028	4.98383674612355	0.518719791810862	0.833820310097216	16:67192168-67198918:+	E2F4	33;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002064,biological_process epithelial cell development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006884,biological_process cell volume homeostasis;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0008015,biological_process blood circulation;GO:0008134,molecular_function transcription factor binding;GO:0008361,biological_process regulation of cell size;GO:0009887,biological_process organ morphogenesis;GO:0019904,molecular_function protein domain specific binding;GO:0030030,biological_process cell projection organization;GO:0042127,biological_process regulation of cell proliferation;GO:0044458,biological_process motile cilium assembly;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0060271,biological_process cilium morphogenesis;GO:0098534,biological_process centriole assembly;GO:1903251,biological_process multi-ciliated epithelial cell differentiation;GO:1990841,molecular_function promoter-specific chromatin binding	E2F4_5; transcription factor E2F4/5; K04682	E2F transcription factor 4 [Source:HGNC Symbol%3BAcc:HGNC:3118]
ENSG00000172531	125.93	128.93	122.96	128.36	138.56	125.18	-0.0420760781194331	7.45868861718821	0.518738081870796	0.833820310097216	11:67398182-67421183:-	PPP1CA	31;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0032091,biological_process negative regulation of protein binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0036496,biological_process regulation of translational initiation by eIF2 alpha dephosphorylation;GO:0042752,biological_process regulation of circadian rhythm;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0072357,cellular_component PTW/PP1 phosphatase complex;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion;GO:1904886,biological_process beta-catenin destruction complex disassembly	PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]; K06269	protein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:9281]
ENSG00000171302	41.47	42.46	36.10	38.86	40.65	37.27	0.0492952618948769	5.75386713144278	0.518768103820306	0.833820310097216	17:78991716-79009867:-	CANT1	25;GO:0004382,molecular_function guanosine-diphosphatase activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0030166,biological_process proteoglycan biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0035580,cellular_component specific granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043262,molecular_function adenosine-diphosphatase activity;GO:0043312,biological_process neutrophil degranulation;GO:0045134,molecular_function uridine-diphosphatase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	CANT1; soluble calcium-activated nucleotidase 1 [EC:3.6.1.6]; K12304	calcium activated nucleotidase 1 [Source:HGNC Symbol%3BAcc:HGNC:19721]
ENSG00000180921	9.11	9.19	8.93	8.11	8.90	9.44	0.0512328637980535	4.99097387107362	0.518800385336425	0.833820310097216	8:143723932-143733801:-	FAM83H	9;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0019901,molecular_function protein kinase binding;GO:0030335,biological_process positive regulation of cell migration;GO:0031214,biological_process biomineral tissue development;GO:0044380,biological_process protein localization to cytoskeleton;GO:0045095,cellular_component keratin filament;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:1990254,molecular_function keratin filament binding	NA	family with sequence similarity 83 member H [Source:HGNC Symbol%3BAcc:HGNC:24797]
ENSG00000153714	18.90	14.95	18.19	19.92	13.53	15.63	0.103742208036703	3.55171940250426	0.518957066468635	0.833820310097216	9:12775020-12822131:+	LURAP1L	NA	NA	leucine rich adaptor protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:31452]
ENSG00000253719	67.71	62.07	64.50	58.66	65.94	63.31	0.0637143859627524	4.22599551870028	0.518979784370925	0.833820310097216	12:74537826-74545430:+	ATXN7L3B	NA	NA	ataxin 7 like 3B [Source:HGNC Symbol%3BAcc:HGNC:37931]
ENSG00000176273	0.96	1.81	1.60	1.15	1.58	1.02	0.210091526862213	0.698637902512268	0.519024497294455	0.833820310097216	10:93893972-93956062:+	SLC35G1	8;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:1990034,biological_process calcium ion export from cell	NA	solute carrier family 35 member G1 [Source:HGNC Symbol%3BAcc:HGNC:26607]
ENSG00000169981	3.26	4.41	3.58	3.41	3.93	4.89	-0.125428413528207	2.66097243767528	0.519072944262287	0.833820310097216	3:44648726-44660791:+	ZNF35	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007283,biological_process spermatogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071300,biological_process cellular response to retinoic acid	NA	zinc finger protein 35 [Source:HGNC Symbol%3BAcc:HGNC:13099]
ENSG00000110619	86.27	76.38	84.17	86.60	81.75	88.11	-0.0425352949875178	7.773951999993	0.519075399157507	0.833820310097216	11:3000921-3057613:-	CARS	14;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004817,molecular_function cysteine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006423,biological_process cysteinyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding	CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]; K01883	cysteinyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:1493]
ENSG00000101084	54.09	64.10	47.81	53.16	53.73	53.00	0.0590296677073154	5.17043495647392	0.51911410266908	0.833820310097216	20:36605733-36612557:+	C20orf24	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 20 open reading frame 24 [Source:HGNC Symbol%3BAcc:HGNC:15870]
ENSG00000149050	3.81	3.63	4.05	3.83	4.30	4.22	-0.0877889853282187	2.88615972885768	0.519189212953533	0.833833057367345	11:6999317-7020368:-	ZNF214	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 214 [Source:HGNC Symbol%3BAcc:HGNC:13006]
ENSG00000160255	0.55	0.22	0.72	0.73	0.33	0.77	-0.240016884699522	0.683979905228836	0.519404445293131	0.834070812344584	21:44885952-44931989:-	ITGB2	57;GO:0001851,molecular_function complement component C3b binding;GO:0002523,biological_process leukocyte migration involved in inflammatory response;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006909,biological_process phagocytosis;GO:0006911,biological_process phagocytosis, engulfment;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007568,biological_process aging;GO:0008305,cellular_component integrin complex;GO:0008360,biological_process regulation of cell shape;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019901,molecular_function protein kinase binding;GO:0030101,biological_process natural killer cell activation;GO:0030198,biological_process extracellular matrix organization;GO:0030369,molecular_function ICAM-3 receptor activity;GO:0030593,biological_process neutrophil chemotaxis;GO:0031072,molecular_function heat shock protein binding;GO:0031623,biological_process receptor internalization;GO:0032403,molecular_function protein complex binding;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0034687,cellular_component integrin alphaL-beta2 complex;GO:0034688,cellular_component integrin alphaM-beta2 complex;GO:0035579,cellular_component specific granule membrane;GO:0035987,biological_process endodermal cell differentiation;GO:0043113,biological_process receptor clustering;GO:0043235,cellular_component receptor complex;GO:0043312,biological_process neutrophil degranulation;GO:0043542,biological_process endothelial cell migration;GO:0045123,biological_process cellular extravasation;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0071404,biological_process cellular response to low-density lipoprotein particle stimulus;GO:0097242,biological_process beta-amyloid clearance;GO:0098742,biological_process cell-cell adhesion via plasma-membrane adhesion molecules;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1903561,cellular_component extracellular vesicle	ITGB2, CD18; integrin beta 2; K06464	integrin subunit beta 2 [Source:HGNC Symbol%3BAcc:HGNC:6155]
ENSG00000139726	101.55	96.20	91.06	98.46	100.62	100.99	-0.0431844377375187	5.89200002689734	0.51958787517261	0.834257443347253	12:122752773-122771064:+	DENR	14;GO:0001731,biological_process formation of translation preinitiation complex;GO:0002188,biological_process translation reinitiation;GO:0003674,molecular_function molecular_function;GO:0003729,molecular_function mRNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0032790,biological_process ribosome disassembly;GO:0043022,molecular_function ribosome binding;GO:0070992,cellular_component translation initiation complex;GO:0075522,biological_process IRES-dependent viral translational initiation	NA	density regulated re-initiation and release factor [Source:HGNC Symbol%3BAcc:HGNC:2769]
ENSG00000167637	3.14	3.41	4.71	3.75	3.97	4.53	-0.10692684160204	3.1114058451878	0.519694431504163	0.834297346480631	19:43827291-43852017:+	ZNF283	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 283 [Source:HGNC Symbol%3BAcc:HGNC:13077]
ENSG00000070718	7.93	6.31	7.73	8.47	6.46	8.83	-0.0928933264490962	3.4063135753336	0.519747150594918	0.834297346480631	8:42152945-42171673:+	AP3M2	13;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008089,biological_process anterograde axonal transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:1904115,cellular_component axon cytoplasm	AP3M; AP-3 complex subunit mu; K12398	adaptor related protein complex 3 mu 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:570]
ENSG00000198961	51.94	53.27	49.07	48.43	50.38	52.18	0.0416019348448601	6.75824599869826	0.519884282006698	0.834409567177287	5:109334708-109409994:-	PJA2	22;GO:0000139,cellular_component Golgi membrane;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007616,biological_process long-term memory;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0035329,biological_process hippo signaling;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	praja ring finger ubiquitin ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:17481]
ENSG00000189366	1.48	1.39	2.01	1.81	0.85	1.36	0.297861690707256	0.106499952639382	0.520073083302244	0.834604199138438	3:125929274-125937039:-	ALG1L	6;GO:0000030,molecular_function mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0006486,biological_process protein glycosylation;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0097502,biological_process mannosylation	NA	ALG1%2C chitobiosyldiphosphodolichol beta-mannosyltransferase like [Source:HGNC Symbol%3BAcc:HGNC:33721]
ENSG00000108107	418.96	414.29	445.96	433.85	387.44	431.02	0.0425874990858199	8.90378135381821	0.520191855015717	0.834604199138438	19:55385344-55403250:+	RPL28	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030425,cellular_component dendrite;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0044297,cellular_component cell body;GO:0070062,cellular_component extracellular exosome;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	RP-L28e, RPL28; large subunit ribosomal protein L28e; K02903	ribosomal protein L28 [Source:HGNC Symbol%3BAcc:HGNC:10330]
ENSG00000005059	36.64	33.28	33.66	35.21	35.36	37.53	-0.0474760254856344	5.16096757919599	0.520207257611705	0.834604199138438	4:109560204-109688726:+	MCUB	16;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0031224,cellular_component intrinsic component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0034704,cellular_component calcium channel complex;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0065009,biological_process regulation of molecular function;GO:1990246,cellular_component uniplex complex	NA	mitochondrial calcium uniporter dominant negative beta subunit [Source:HGNC Symbol%3BAcc:HGNC:26076]
ENSG00000135318	39.58	31.99	38.47	40.06	28.54	37.06	0.0722443959275612	6.06373872182582	0.520364498997446	0.834683502498762	6:85449583-85495791:+	NT5E	21;GO:0000166,molecular_function nucleotide binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006195,biological_process purine nucleotide catabolic process;GO:0006196,biological_process AMP catabolic process;GO:0006259,biological_process DNA metabolic process;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0009166,biological_process nucleotide catabolic process;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0019674,biological_process NAD metabolic process;GO:0031225,cellular_component anchored component of membrane;GO:0046086,biological_process adenosine biosynthetic process;GO:0046135,biological_process pyrimidine nucleoside catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050728,biological_process negative regulation of inflammatory response;GO:0070062,cellular_component extracellular exosome	E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]; K01081	5'-nucleotidase ecto [Source:HGNC Symbol%3BAcc:HGNC:8021]
ENSG00000078668	54.46	59.48	55.16	55.34	60.48	60.02	-0.0480981848427141	5.65524944659303	0.520391172628528	0.834683502498762	8:42391623-42405897:+	VDAC3	22;GO:0000166,molecular_function nucleotide binding;GO:0001662,biological_process behavioral fear response;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007270,biological_process neuron-neuron synaptic transmission;GO:0007612,biological_process learning;GO:0008308,molecular_function voltage-gated anion channel activity;GO:0015288,molecular_function porin activity;GO:0015853,biological_process adenine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046930,cellular_component pore complex;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0098656,biological_process anion transmembrane transport;GO:1902017,biological_process regulation of cilium assembly;GO:1903959,biological_process regulation of anion transmembrane transport	VDAC3; voltage-dependent anion channel protein 3; K15041	voltage dependent anion channel 3 [Source:HGNC Symbol%3BAcc:HGNC:12674]
ENSG00000160949	5.61	6.22	5.99	5.92	5.18	6.13	0.0568333590939822	4.61679212703966	0.52053340169559	0.834803761659866	8:144428774-144444444:-	TONSL	17;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016604,cellular_component nuclear body;GO:0031297,biological_process replication fork processing;GO:0035101,cellular_component FACT complex;GO:0042393,molecular_function histone binding;GO:0042555,cellular_component MCM complex;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0043596,cellular_component nuclear replication fork;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	tonsoku like%2C DNA repair protein [Source:HGNC Symbol%3BAcc:HGNC:7801]
ENSG00000197872	25.51	27.22	24.99	29.13	28.10	24.38	-0.0607907075722074	4.69298228505557	0.520790549319046	0.83498420921378	2:16549458-16666331:-	FAM49A	1;GO:0005622,cellular_component intracellular	NA	family with sequence similarity 49 member A [Source:HGNC Symbol%3BAcc:HGNC:25373]
ENSG00000101856	141.98	141.96	128.96	127.22	146.24	129.10	0.0477747320989618	6.31592104618009	0.520798236499916	0.83498420921378	X:119236244-119244466:+	PGRMC1	20;GO:0005496,molecular_function steroid binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0020037,molecular_function heme binding;GO:0031090,cellular_component organelle membrane;GO:0035579,cellular_component specific granule membrane;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0044297,cellular_component cell body;GO:0045202,cellular_component synapse;GO:0070062,cellular_component extracellular exosome;GO:0106003,cellular_component amyloid-beta complex	NA	progesterone receptor membrane component 1 [Source:HGNC Symbol%3BAcc:HGNC:16090]
ENSG00000123136	33.08	38.05	33.00	30.88	34.93	35.26	0.049958769389118	5.57823958909843	0.520935267819546	0.83498420921378	19:14408818-14419383:-	DDX39A	27;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008380,biological_process RNA splicing;GO:0010468,biological_process regulation of gene expression;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0031124,biological_process mRNA 3'-end processing;GO:0042802,molecular_function identical protein binding	NA	DExD-box helicase 39A [Source:HGNC Symbol%3BAcc:HGNC:17821]
ENSG00000183475	8.03	6.58	9.67	8.74	8.30	9.31	-0.0943890532061401	3.05414742268081	0.520975378082911	0.83498420921378	15:100602533-100651705:+	ASB7	6;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	ankyrin repeat and SOCS box containing 7 [Source:HGNC Symbol%3BAcc:HGNC:17182]
ENSG00000163605	36.91	35.97	36.06	35.80	34.74	36.12	0.0426882946004681	5.60256214617369	0.520982252506302	0.83498420921378	3:72996784-73069199:+	PPP4R2	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006397,biological_process mRNA processing;GO:0006464,biological_process cellular protein modification process;GO:0008380,biological_process RNA splicing;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030289,cellular_component protein phosphatase 4 complex;GO:0030674,molecular_function protein binding, bridging;GO:0050790,biological_process regulation of catalytic activity	NA	protein phosphatase 4 regulatory subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:18296]
ENSG00000198799	6.32	6.22	5.90	6.70	6.12	6.54	-0.0598621072665682	4.34343103263358	0.521129211813727	0.835036517656734	1:113073208-113132260:+	LRIG2	18;GO:0005102,molecular_function receptor binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007605,biological_process sensory perception of sound;GO:0010640,biological_process regulation of platelet-derived growth factor receptor signaling pathway;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030426,cellular_component growth cone;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0048679,biological_process regulation of axon regeneration;GO:0048681,biological_process negative regulation of axon regeneration;GO:0051045,biological_process negative regulation of membrane protein ectodomain proteolysis;GO:0060384,biological_process innervation;GO:0097708,cellular_component intracellular vesicle;GO:2000010,biological_process positive regulation of protein localization to cell surface;GO:2001222,biological_process regulation of neuron migration	NA	leucine rich repeats and immunoglobulin like domains 2 [Source:HGNC Symbol%3BAcc:HGNC:20889]
ENSG00000163882	83.41	75.72	84.54	80.29	83.50	90.68	-0.0476986674079824	5.45386351894792	0.521149432231267	0.835036517656734	3:184361717-184368596:+	POLR2H	33;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001054,molecular_function RNA polymerase I activity;GO:0001055,molecular_function RNA polymerase II activity;GO:0001056,molecular_function RNA polymerase III activity;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005730,cellular_component nucleolus;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032993,cellular_component protein-DNA complex;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB8, POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3; K03016	RNA polymerase II subunit H [Source:HGNC Symbol%3BAcc:HGNC:9195]
ENSG00000148303	1688.61	1676.41	1617.14	1648.88	1590.28	1659.09	0.0362719122426656	10.5053944195757	0.521494476452359	0.835225007404044	9:133348213-133351426:+	RPL7A	23;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042254,biological_process ribosome biogenesis;GO:0042788,cellular_component polysomal ribosome;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	RP-L7Ae, RPL7A; large subunit ribosomal protein L7Ae; K02936	ribosomal protein L7a [Source:HGNC Symbol%3BAcc:HGNC:10364]
ENSG00000079974	18.94	19.45	25.71	23.48	23.16	21.76	-0.0769448902498001	4.02239807438441	0.521578136856454	0.835225007404044	22:50767500-50783663:-	RABL2B	5;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction	NA	RAB%2C member of RAS oncogene family like 2B [Source:HGNC Symbol%3BAcc:HGNC:9800]
ENSG00000249931	0.78	0.40	1.01	0.91	0.88	0.86	-0.210104233267218	0.772701473826877	0.52162402037534	0.835225007404044	15:32392781-32403292:-	GOLGA8K	1;GO:0005794,cellular_component Golgi apparatus	NA	golgin A8 family member K [Source:HGNC Symbol%3BAcc:HGNC:38652]
ENSG00000198752	66.93	63.86	69.86	68.93	68.93	69.94	-0.0382686323659906	8.46403146413516	0.521680476064393	0.835225007404044	14:102932378-103057462:-	CDC42BPB	29;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006468,biological_process protein phosphorylation;GO:0007010,biological_process cytoskeleton organization;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0031032,biological_process actomyosin structure organization;GO:0031252,cellular_component cell leading edge;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0035556,biological_process intracellular signal transduction;GO:0042641,cellular_component actomyosin;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	CDC42 binding protein kinase beta [Source:HGNC Symbol%3BAcc:HGNC:1738]
ENSG00000076003	29.74	33.52	28.75	33.16	30.36	32.23	-0.0493479558595044	6.27073267773112	0.52176860545972	0.835225007404044	2:135839625-135876426:-	MCM6	19;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003697,molecular_function single-stranded DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0007049,biological_process cell cycle;GO:0016787,molecular_function hydrolase activity;GO:0042555,cellular_component MCM complex;GO:0042802,molecular_function identical protein binding	MCM6; DNA replication licensing factor MCM6 [EC:3.6.4.12]; K02542	minichromosome maintenance complex component 6 [Source:HGNC Symbol%3BAcc:HGNC:6949]
ENSG00000101752	9.45	8.04	8.41	8.68	8.87	9.67	-0.0550750965344422	4.75247736694223	0.521784147208531	0.835225007404044	18:21704956-21870957:+	MIB1	25;GO:0001568,biological_process blood vessel development;GO:0001701,biological_process in utero embryonic development;GO:0001756,biological_process somitogenesis;GO:0001841,biological_process neural tube formation;GO:0001947,biological_process heart looping;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0007219,biological_process Notch signaling pathway;GO:0007507,biological_process heart development;GO:0008270,molecular_function zinc ion binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045807,biological_process positive regulation of endocytosis;GO:0046872,molecular_function metal ion binding	NA	mindbomb E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:21086]
ENSG00000103150	4.25	4.33	3.53	4.30	4.56	4.18	-0.100884286745363	2.66638880111649	0.521869101012851	0.835225007404044	16:83899125-83927026:+	MLYCD	18;GO:0002931,biological_process response to ischemia;GO:0005102,molecular_function receptor binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006085,biological_process acetyl-CoA biosynthetic process;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0046321,biological_process positive regulation of fatty acid oxidation;GO:0050080,molecular_function malonyl-CoA decarboxylase activity;GO:2001294,biological_process malonyl-CoA catabolic process	MLYCD; malonyl-CoA decarboxylase [EC:4.1.1.9]; K01578	malonyl-CoA decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:7150]
ENSG00000175595	4.42	4.74	4.05	5.00	4.71	4.27	-0.0766480415436542	3.67173275570132	0.521879531419006	0.835225007404044	16:13920156-13952345:+	ERCC4	44;GO:0000109,cellular_component nucleotide-excision repair complex;GO:0000110,cellular_component nucleotide-excision repair factor 1 complex;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008022,molecular_function protein C-terminus binding;GO:0009411,biological_process response to UV;GO:0009650,biological_process UV protection;GO:0016787,molecular_function hydrolase activity;GO:0032205,biological_process negative regulation of telomere maintenance;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034644,biological_process cellular response to UV;GO:0036297,biological_process interstrand cross-link repair;GO:0047485,molecular_function protein N-terminus binding;GO:0061819,biological_process telomeric DNA-containing double minutes formation;GO:0070522,cellular_component ERCC4-ERCC1 complex;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1901255,biological_process nucleotide-excision repair involved in interstrand cross-link repair;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1905765,biological_process negative regulation of protection from non-homologous end joining at telomere;GO:1905768,biological_process negative regulation of double-stranded telomeric DNA binding;GO:1990599,molecular_function 3' overhang single-stranded DNA endodeoxyribonuclease activity	ERCC4, XPF; DNA excision repair protein ERCC-4 [EC:3.1.-.-]; K10848	ERCC excision repair 4%2C endonuclease catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:3436]
ENSG00000227051	1.78	2.41	2.60	2.84	2.87	2.49	-0.263641288835826	0.189216232404719	0.521933766013056	0.835225007404044	14:96039323-96093889:+	C14orf132	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 14 open reading frame 132 [Source:HGNC Symbol%3BAcc:HGNC:20346]
ENSG00000140365	45.98	53.14	44.68	42.80	52.28	43.49	0.0609621796564948	5.05558842559337	0.521952031975821	0.835225007404044	15:75335890-75343224:+	COMMD4	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	COMM domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:26027]
ENSG00000163527	90.15	92.87	89.25	84.51	92.95	89.47	0.0399964486155093	7.80064379111994	0.522007218838361	0.835225007404044	3:31532637-31637622:+	STT3B	17;GO:0004576,molecular_function oligosaccharyl transferase activity;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006516,biological_process glycoprotein catabolic process;GO:0006986,biological_process response to unfolded protein;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0043686,biological_process co-translational protein modification;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	STT3; dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18]; K07151	STT3B%2C catalytic subunit of the oligosaccharyltransferase complex [Source:HGNC Symbol%3BAcc:HGNC:30611]
ENSG00000156521	9.61	8.39	9.10	7.98	8.89	9.23	0.071005622977208	3.93044038120781	0.522143181919589	0.83533487784094	10:70137980-70146676:-	TYSND1	11;GO:0002020,molecular_function protease binding;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005777,cellular_component peroxisome;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0031998,biological_process regulation of fatty acid beta-oxidation;GO:0051260,biological_process protein homooligomerization	NA	trypsin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28531]
ENSG00000184402	5.31	5.76	4.99	5.35	5.20	4.61	0.0901544644006359	2.83071155864	0.522408053986309	0.835650924501553	20:62143794-62182484:+	SS18L1	19;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016358,biological_process dendrite development;GO:0016569,biological_process covalent chromatin modification;GO:0016604,cellular_component nuclear body;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050773,biological_process regulation of dendrite development;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0071565,cellular_component nBAF complex;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	SS18L1%2C nBAF chromatin remodeling complex subunit [Source:HGNC Symbol%3BAcc:HGNC:15592]
ENSG00000073584	134.10	142.80	126.33	126.61	136.98	130.82	0.0426891247439365	7.52296309912178	0.522855696255744	0.836259213712479	17:40624961-40648508:-	SMARCE1	29;GO:0000228,cellular_component nuclear chromosome;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0017053,cellular_component transcriptional repressor complex;GO:0022008,biological_process neurogenesis;GO:0031492,molecular_function nucleosomal DNA binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:0090544,cellular_component BAF-type complex	SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1; K11651	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily e%2C member 1 [Source:HGNC Symbol%3BAcc:HGNC:11109]
ENSG00000125398	1.67	1.38	0.77	1.18	1.09	1.06	0.20462872005486	0.973639056053832	0.523004288207919	0.836389104551005	17:72121019-72126420:+	SOX9	154;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0001502,biological_process cartilage condensation;GO:0001503,biological_process ossification;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001708,biological_process cell fate specification;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001894,biological_process tissue homeostasis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001942,biological_process hair follicle development;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002062,biological_process chondrocyte differentiation;GO:0002063,biological_process chondrocyte development;GO:0002683,biological_process negative regulation of immune system process;GO:0003170,biological_process heart valve development;GO:0003179,biological_process heart valve morphogenesis;GO:0003188,biological_process heart valve formation;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003413,biological_process chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0003415,biological_process chondrocyte hypertrophy;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006334,biological_process nucleosome assembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007219,biological_process Notch signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0007417,biological_process central nervous system development;GO:0007507,biological_process heart development;GO:0008013,molecular_function beta-catenin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0010564,biological_process regulation of cell cycle process;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0014032,biological_process neural crest cell development;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019100,biological_process male germ-line sex determination;GO:0019933,biological_process cAMP-mediated signaling;GO:0030154,biological_process cell differentiation;GO:0030155,biological_process regulation of cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030238,biological_process male sex determination;GO:0030279,biological_process negative regulation of ossification;GO:0030502,biological_process negative regulation of bone mineralization;GO:0030850,biological_process prostate gland development;GO:0030857,biological_process negative regulation of epithelial cell differentiation;GO:0030858,biological_process positive regulation of epithelial cell differentiation;GO:0030879,biological_process mammary gland development;GO:0030903,biological_process notochord development;GO:0030916,biological_process otic vesicle formation;GO:0031018,biological_process endocrine pancreas development;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0032808,biological_process lacrimal gland development;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0034504,biological_process protein localization to nucleus;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035326,molecular_function enhancer binding;GO:0035622,biological_process intrahepatic bile duct development;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043491,biological_process protein kinase B signaling;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044798,cellular_component nuclear transcription factor complex;GO:0045165,biological_process cell fate commitment;GO:0045595,biological_process regulation of cell differentiation;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046533,biological_process negative regulation of photoreceptor cell differentiation;GO:0046982,molecular_function protein heterodimerization activity;GO:0048709,biological_process oligodendrocyte differentiation;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051216,biological_process cartilage development;GO:0060008,biological_process Sertoli cell differentiation;GO:0060009,biological_process Sertoli cell development;GO:0060018,biological_process astrocyte fate commitment;GO:0060041,biological_process retina development in camera-type eye;GO:0060174,biological_process limb bud formation;GO:0060221,biological_process retinal rod cell differentiation;GO:0060350,biological_process endochondral bone morphogenesis;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060487,biological_process lung epithelial cell differentiation;GO:0060512,biological_process prostate gland morphogenesis;GO:0060517,biological_process epithelial cell proliferation involved in prostatic bud elongation;GO:0060532,biological_process bronchus cartilage development;GO:0060534,biological_process trachea cartilage development;GO:0060729,biological_process intestinal epithelial structure maintenance;GO:0060784,biological_process regulation of cell proliferation involved in tissue homeostasis;GO:0061036,biological_process positive regulation of cartilage development;GO:0061046,biological_process regulation of branching involved in lung morphogenesis;GO:0061138,biological_process morphogenesis of a branching epithelium;GO:0061145,biological_process lung smooth muscle development;GO:0070168,biological_process negative regulation of biomineral tissue development;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070384,biological_process Harderian gland development;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071300,biological_process cellular response to retinoic acid;GO:0071347,biological_process cellular response to interleukin-1;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071504,biological_process cellular response to heparin;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071599,biological_process otic vesicle development;GO:0072034,biological_process renal vesicle induction;GO:0072170,biological_process metanephric tubule development;GO:0072189,biological_process ureter development;GO:0072190,biological_process ureter urothelium development;GO:0072193,biological_process ureter smooth muscle cell differentiation;GO:0072197,biological_process ureter morphogenesis;GO:0072289,biological_process metanephric nephron tubule formation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090103,biological_process cochlea morphogenesis;GO:0090184,biological_process positive regulation of kidney development;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0097157,molecular_function pre-mRNA intronic binding;GO:1901203,biological_process positive regulation of extracellular matrix assembly;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:2000020,biological_process positive regulation of male gonad development;GO:2000138,biological_process positive regulation of cell proliferation involved in heart morphogenesis;GO:2000741,biological_process positive regulation of mesenchymal stem cell differentiation;GO:2000794,biological_process regulation of epithelial cell proliferation involved in lung morphogenesis;GO:2001054,biological_process negative regulation of mesenchymal cell apoptotic process	NA	SRY-box 9 [Source:HGNC Symbol%3BAcc:HGNC:11204]
ENSG00000104936	23.21	20.48	24.07	23.66	20.58	21.78	0.0532621923752066	5.73048476708399	0.523152694151643	0.836518664498821	19:45769716-45782552:-	DMPK	41;GO:0000166,molecular_function nucleotide binding;GO:0002028,biological_process regulation of sodium ion transport;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006998,biological_process nuclear envelope organization;GO:0008016,biological_process regulation of heart contraction;GO:0010657,biological_process muscle cell apoptotic process;GO:0010830,biological_process regulation of myotube differentiation;GO:0014722,biological_process regulation of skeletal muscle contraction by calcium ion signaling;GO:0014853,biological_process regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016740,molecular_function transferase activity;GO:0017020,molecular_function myosin phosphatase regulator activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030036,biological_process actin cytoskeleton organization;GO:0031072,molecular_function heat shock protein binding;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0031965,cellular_component nuclear membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0046872,molecular_function metal ion binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051823,biological_process regulation of synapse structural plasticity;GO:1903779,biological_process regulation of cardiac conduction	NA	DM1 protein kinase [Source:HGNC Symbol%3BAcc:HGNC:2933]
ENSG00000196981	14.34	9.85	11.23	12.25	13.02	12.86	-0.0825947025872725	3.62850060053499	0.523349651027511	0.836644215516764	3:122412331-122416051:-	WDR5B	2;GO:0036064,cellular_component ciliary basal body;GO:0060271,biological_process cilium morphogenesis	WDR5, SWD3, CPS30; COMPASS component SWD3; K14963	WD repeat domain 5B [Source:HGNC Symbol%3BAcc:HGNC:17826]
ENSG00000157168	2.65	3.48	3.02	2.95	2.76	2.96	0.0758828652399215	3.47343512111549	0.52341777048223	0.836644215516764	8:31639385-32767959:+	NRG1	96;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0000902,biological_process cell morphogenesis;GO:0001964,biological_process startle response;GO:0003161,biological_process cardiac conduction system development;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003712,molecular_function transcription cofactor activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005176,molecular_function ErbB-2 class receptor binding;GO:0005178,molecular_function integrin binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007154,biological_process cell communication;GO:0007171,biological_process activation of transmembrane receptor protein tyrosine kinase activity;GO:0007399,biological_process nervous system development;GO:0007416,biological_process synapse assembly;GO:0007420,biological_process brain development;GO:0007422,biological_process peripheral nervous system development;GO:0007507,biological_process heart development;GO:0007517,biological_process muscle organ development;GO:0007626,biological_process locomotory behavior;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008366,biological_process axon ensheathment;GO:0009790,biological_process embryo development;GO:0009897,cellular_component external side of plasma membrane;GO:0010001,biological_process glial cell differentiation;GO:0010628,biological_process positive regulation of gene expression;GO:0014032,biological_process neural crest cell development;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021781,biological_process glial cell fate commitment;GO:0021842,biological_process chemorepulsion involved in interneuron migration from the subpallium to the cortex;GO:0022008,biological_process neurogenesis;GO:0030297,molecular_function transmembrane receptor protein tyrosine kinase activator activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030673,cellular_component axolemma;GO:0030879,biological_process mammary gland development;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031594,cellular_component neuromuscular junction;GO:0031643,biological_process positive regulation of myelination;GO:0032148,biological_process activation of protein kinase B activity;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038127,biological_process ERBB signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0038129,biological_process ERBB3 signaling pathway;GO:0042060,biological_process wound healing;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0043125,molecular_function ErbB-3 class receptor binding;GO:0043496,biological_process regulation of protein homodimerization activity;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044297,cellular_component cell body;GO:0045202,cellular_component synapse;GO:0045213,biological_process neurotransmitter receptor metabolic process;GO:0045499,molecular_function chemorepellent activity;GO:0045595,biological_process regulation of cell differentiation;GO:0045773,biological_process positive regulation of axon extension;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048663,biological_process neuron fate commitment;GO:0048709,biological_process oligodendrocyte differentiation;GO:0048738,biological_process cardiac muscle tissue development;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051048,biological_process negative regulation of secretion;GO:0051155,biological_process positive regulation of striated muscle cell differentiation;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060379,biological_process cardiac muscle cell myoblast differentiation;GO:0060956,biological_process endocardial cell differentiation;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0070886,biological_process positive regulation of calcineurin-NFAT signaling cascade;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2000010,biological_process positive regulation of protein localization to cell surface;GO:2000145,biological_process regulation of cell motility;GO:2000727,biological_process positive regulation of cardiac muscle cell differentiation;GO:2001223,biological_process negative regulation of neuron migration	NRG1; neuregulin 1; K05455	neuregulin 1 [Source:HGNC Symbol%3BAcc:HGNC:7997]
ENSG00000266412	48.42	53.68	51.59	50.95	51.42	47.85	0.0433667376629717	6.63048754886139	0.523535196742686	0.836644215516764	10:46005087-46030714:-	NCOA4	13;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006622,biological_process protein targeting to lysosome;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008584,biological_process male gonad development;GO:0009725,biological_process response to hormone;GO:0030521,biological_process androgen receptor signaling pathway;GO:0044754,cellular_component autolysosome;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050681,molecular_function androgen receptor binding	NCOA4, PTC3; nuclear receptor coactivator 4; K09289	nuclear receptor coactivator 4 [Source:HGNC Symbol%3BAcc:HGNC:7671]
ENSG00000186716	11.47	9.17	10.33	11.19	10.38	10.90	-0.0509366452246934	5.34291372353464	0.5235814358982	0.836644215516764	22:23179703-23318037:+	BCR	53;GO:0000166,molecular_function nucleotide binding;GO:0002692,biological_process negative regulation of cellular extravasation;GO:0003014,biological_process renal system process;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007420,biological_process brain development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030336,biological_process negative regulation of cell migration;GO:0032496,biological_process response to lipopolysaccharide;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042472,biological_process inner ear morphogenesis;GO:0043114,biological_process regulation of vascular permeability;GO:0043234,cellular_component protein complex;GO:0043314,biological_process negative regulation of neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046777,biological_process protein autophosphorylation;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048872,biological_process homeostasis of number of cells;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051171,biological_process regulation of nitrogen compound metabolic process;GO:0051726,biological_process regulation of cell cycle;GO:0060216,biological_process definitive hemopoiesis;GO:0060268,biological_process negative regulation of respiratory burst;GO:0060313,biological_process negative regulation of blood vessel remodeling;GO:0065002,biological_process intracellular protein transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]; K08878	BCR%2C RhoGEF and GTPase activating protein [Source:HGNC Symbol%3BAcc:HGNC:1014]
ENSG00000119844	20.55	19.04	20.03	18.86	20.72	18.74	0.0464824845562785	5.79335899354923	0.523581954308219	0.836644215516764	2:64524304-64593005:+	AFTPH	10;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0030121,cellular_component AP-1 adaptor complex;GO:0030276,molecular_function clathrin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	aftiphilin [Source:HGNC Symbol%3BAcc:HGNC:25951]
ENSG00000104375	26.48	23.40	23.45	24.28	26.30	25.96	-0.0473753481129738	5.44581059369473	0.523635616720353	0.836644215516764	8:98401402-98942827:-	STK3	44;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001841,biological_process neural tube formation;GO:0003157,biological_process endocardium development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007417,biological_process central nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032092,biological_process positive regulation of protein binding;GO:0035329,biological_process hippo signaling;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046621,biological_process negative regulation of organ growth;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0050821,biological_process protein stabilization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060215,biological_process primitive hemopoiesis;GO:0060706,biological_process cell differentiation involved in embryonic placenta development;GO:0060800,biological_process regulation of cell differentiation involved in embryonic placenta development;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097284,biological_process hepatocyte apoptotic process;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	STK3, MST2; serine/threonine kinase 3; K04412	serine/threonine kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:11406]
ENSG00000154429	3.21	3.89	3.79	3.14	5.00	3.96	-0.144842687406356	1.74205563311902	0.523883725305035	0.836787609217131	1:229321004-229343294:-	CCSAP	24;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0008017,molecular_function microtubule binding;GO:0030424,cellular_component axon;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045995,biological_process regulation of embryonic development;GO:0048666,biological_process neuron development;GO:0051301,biological_process cell division;GO:0060296,biological_process regulation of cilium beat frequency involved in ciliary motility;GO:0061673,cellular_component mitotic spindle astral microtubule;GO:0072686,cellular_component mitotic spindle;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1990755,biological_process mitotic spindle microtubule depolymerization	NA	centriole%2C cilia and spindle associated protein [Source:HGNC Symbol%3BAcc:HGNC:29578]
ENSG00000136098	3.58	4.03	3.64	3.60	3.05	3.84	0.100997052416741	2.49562710395394	0.523973897655515	0.836787609217131	13:52132638-52159861:-	NEK3	20;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030010,biological_process establishment of cell polarity;GO:0030424,cellular_component axon;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0051301,biological_process cell division;GO:0090043,biological_process regulation of tubulin deacetylation	NA	NIMA related kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:7746]
ENSG00000131931	11.72	14.21	14.05	15.70	14.48	12.66	-0.0928204300951246	3.16226351262221	0.523992687033145	0.836787609217131	8:42836673-42843325:-	THAP1	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0001935,biological_process endothelial cell proliferation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0016605,cellular_component PML body;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20856]
ENSG00000168734	69.84	63.59	62.11	66.52	71.05	68.23	-0.0588243417924125	4.18399023855527	0.523995012200496	0.836787609217131	20:44531784-44624247:+	PKIG	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007165,biological_process signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0042308,biological_process negative regulation of protein import into nucleus;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity	NA	cAMP-dependent protein kinase inhibitor gamma [Source:HGNC Symbol%3BAcc:HGNC:9019]
ENSG00000165490	4.70	4.33	4.88	4.52	4.91	5.27	-0.0636244967267002	3.95008353982604	0.524280019459918	0.837135050367373	11:82899974-82958277:+	DDIAS	5;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest	NA	DNA damage induced apoptosis suppressor [Source:HGNC Symbol%3BAcc:HGNC:26351]
ENSG00000213139	7.80	6.26	7.72	7.15	6.39	6.72	0.130897806251212	1.96791820139208	0.524451950134941	0.83723972505151	3:186538440-186546702:-	CRYGS	3;GO:0002009,biological_process morphogenesis of an epithelium;GO:0002088,biological_process lens development in camera-type eye;GO:0005212,molecular_function structural constituent of eye lens	NA	crystallin gamma S [Source:HGNC Symbol%3BAcc:HGNC:2417]
ENSG00000184307	2.54	3.24	2.14	2.03	2.52	2.62	0.133398733016395	1.93731361201997	0.524555713723602	0.83723972505151	3:113947900-113965401:+	ZDHHC23	7;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0072659,biological_process protein localization to plasma membrane	NA	zinc finger DHHC-type containing 23 [Source:HGNC Symbol%3BAcc:HGNC:28654]
ENSG00000153294	4.67	3.63	5.88	5.40	4.65	5.32	-0.0927549377496589	3.54165580783193	0.524614172563216	0.83723972505151	6:47685863-47722021:+	ADGRF4	8;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	adhesion G protein-coupled receptor F4 [Source:HGNC Symbol%3BAcc:HGNC:19011]
ENSG00000213420	1.42	1.16	1.53	1.34	1.48	1.82	-0.15414810184518	1.43744303750383	0.524661431636198	0.83723972505151	7:100169605-100177372:-	GPC2	16;GO:0001523,biological_process retinoid metabolic process;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0030182,biological_process neuron differentiation;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0031225,cellular_component anchored component of membrane;GO:0043202,cellular_component lysosomal lumen;GO:0043395,molecular_function heparan sulfate proteoglycan binding	NA	glypican 2 [Source:HGNC Symbol%3BAcc:HGNC:4450]
ENSG00000108604	33.21	29.89	30.02	34.99	31.11	31.06	-0.0473192637565198	5.7702105083291	0.524682818108088	0.83723972505151	17:63832080-63843065:-	SMARCD2	18;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0031492,molecular_function nucleosomal DNA binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0090544,cellular_component BAF-type complex	SMARCD; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D; K11650	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily d%2C member 2 [Source:HGNC Symbol%3BAcc:HGNC:11107]
ENSG00000130940	0.70	0.80	0.77	0.73	0.88	0.87	-0.119661645709389	2.17714602585686	0.524896020661493	0.837284645765272	1:10636603-10796650:-	CASZ1	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045664,biological_process regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	castor zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:26002]
ENSG00000140577	7.07	6.24	6.12	7.14	6.47	7.04	-0.0718563542064266	3.68585096889718	0.524919406194858	0.837284645765272	15:90529924-90645345:+	CRTC3	15;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008140,molecular_function cAMP response element binding protein binding;GO:0016032,biological_process viral process;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0042116,biological_process macrophage activation;GO:0043951,biological_process negative regulation of cAMP-mediated signaling;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050995,biological_process negative regulation of lipid catabolic process;GO:0051289,biological_process protein homotetramerization;GO:0097009,biological_process energy homeostasis	CRTC3, TORC3; CREB-regulated transcription coactivator 3; K16334	CREB regulated transcription coactivator 3 [Source:HGNC Symbol%3BAcc:HGNC:26148]
ENSG00000152457	5.37	5.03	6.13	4.41	5.36	5.95	0.0875912682325134	3.60098125823418	0.524959665075708	0.837284645765272	10:14897358-14954432:-	DCLRE1C	29;GO:0000014,molecular_function single-stranded DNA endodeoxyribonuclease activity;GO:0000723,biological_process telomere maintenance;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0003684,molecular_function damaged DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0010212,biological_process response to ionizing radiation;GO:0016787,molecular_function hydrolase activity;GO:0030183,biological_process B cell differentiation;GO:0031848,biological_process protection from non-homologous end joining at telomere;GO:0033151,biological_process V(D)J recombination;GO:0035312,molecular_function 5'-3' exodeoxyribonuclease activity;GO:0036297,biological_process interstrand cross-link repair;GO:0051276,biological_process chromosome organization;GO:0070419,cellular_component nonhomologous end joining complex;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	DCLRE1C, ARTEMIS, SCIDA; DNA cross-link repair 1C protein [EC:3.1.-.-]; K10887	DNA cross-link repair 1C [Source:HGNC Symbol%3BAcc:HGNC:17642]
ENSG00000108179	40.11	47.78	46.39	42.95	45.55	41.53	0.0540083144304572	4.96379434160253	0.525067207037828	0.837284645765272	10:79347468-79355337:+	PPIF	33;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0002931,biological_process response to ischemia;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005759,cellular_component mitochondrial matrix;GO:0006457,biological_process protein folding;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0010849,biological_process regulation of proton-transporting ATPase activity, rotational mechanism;GO:0010939,biological_process regulation of necrotic cell death;GO:0012501,biological_process programmed cell death;GO:0016018,molecular_function cyclosporin A binding;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0032780,biological_process negative regulation of ATPase activity;GO:0042277,molecular_function peptide binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0070266,biological_process necroptotic process;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0071277,biological_process cellular response to calcium ion;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0090324,biological_process negative regulation of oxidative phosphorylation;GO:1902445,biological_process regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:2000276,biological_process negative regulation of oxidative phosphorylation uncoupler activity;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]; K09565	peptidylprolyl isomerase F [Source:HGNC Symbol%3BAcc:HGNC:9259]
ENSG00000103876	62.54	66.71	67.48	69.23	64.90	70.10	-0.0433744996264785	6.41621991564086	0.525098770775589	0.837284645765272	15:80152489-80186946:+	FAH	12;GO:0003824,molecular_function catalytic activity;GO:0004334,molecular_function fumarylacetoacetase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006527,biological_process arginine catabolic process;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0006572,biological_process tyrosine catabolic process;GO:0008152,biological_process metabolic process;GO:0009072,biological_process aromatic amino acid family metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	FAH, fahA; fumarylacetoacetase [EC:3.7.1.2]; K01555	fumarylacetoacetate hydrolase [Source:HGNC Symbol%3BAcc:HGNC:3579]
ENSG00000165209	18.59	21.29	19.76	19.96	21.23	20.88	-0.0506699623319286	5.4177650640842	0.525115682533041	0.837284645765272	9:123109499-123268576:-	STRBP	13;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0007638,biological_process mechanosensory behavior;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030154,biological_process cell differentiation	NA	spermatid perinuclear RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:16462]
ENSG00000139180	39.52	38.86	34.18	37.57	40.62	39.05	-0.0482804322158271	5.76862749273805	0.525255756469148	0.83736051510986	12:4649094-4694317:+	NDUFA9	18;GO:0003824,molecular_function catalytic activity;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005759,cellular_component mitochondrial matrix;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006814,biological_process sodium ion transport;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0031966,cellular_component mitochondrial membrane;GO:0032403,molecular_function protein complex binding;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0050662,molecular_function coenzyme binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1901006,biological_process ubiquinone-6 biosynthetic process	NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9; K03953	NADH:ubiquinone oxidoreductase subunit A9 [Source:HGNC Symbol%3BAcc:HGNC:7693]
ENSG00000159210	79.74	80.40	73.35	80.26	83.12	78.99	-0.0432211936103858	6.12200463639232	0.525353846010255	0.83736051510986	17:48929315-48945117:-	SNF8	40;GO:0000814,cellular_component ESCRT II complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0010008,cellular_component endosome membrane;GO:0010628,biological_process positive regulation of gene expression;GO:0010797,biological_process regulation of multivesicular body size involved in endosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016247,molecular_function channel regulator activity;GO:0031902,cellular_component late endosome membrane;GO:0032456,biological_process endocytic recycling;GO:0036258,biological_process multivesicular body assembly;GO:0042176,biological_process regulation of protein catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043328,biological_process protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0045022,biological_process early endosome to late endosome transport;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0047485,molecular_function protein N-terminus binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0061635,biological_process regulation of protein complex stability;GO:0065009,biological_process regulation of molecular function;GO:0070062,cellular_component extracellular exosome;GO:0071985,biological_process multivesicular body sorting pathway;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903772,biological_process regulation of viral budding via host ESCRT complex	SNF8, EAP30; ESCRT-II complex subunit VPS22; K12188	SNF8%2C ESCRT-II complex subunit [Source:HGNC Symbol%3BAcc:HGNC:17028]
ENSG00000026950	20.52	18.74	22.13	22.16	19.93	22.22	-0.0511238782019433	5.1582950601853	0.525365640189768	0.83736051510986	6:26402236-26415216:+	BTN3A1	10;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050663,biological_process cytokine secretion;GO:0050798,biological_process activated T cell proliferation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0072643,biological_process interferon-gamma secretion	NA	butyrophilin subfamily 3 member A1 [Source:HGNC Symbol%3BAcc:HGNC:1138]
ENSG00000186501	28.12	28.45	32.77	27.34	27.50	31.49	0.0621501568483152	4.53611897400026	0.525571057932184	0.837422210737387	1:27322144-27336400:+	TMEM222	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 222 [Source:HGNC Symbol%3BAcc:HGNC:25363]
ENSG00000076928	19.31	19.25	18.88	18.17	18.86	19.28	0.039750012410454	6.19410521778746	0.525629207445734	0.837422210737387	19:41883160-41930150:+	ARHGEF1	16;GO:0003723,molecular_function RNA binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007266,biological_process Rho protein signal transduction;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050771,biological_process negative regulation of axonogenesis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	ARHGEF1; Rho guanine nucleotide exchange factor 1; K12330	Rho guanine nucleotide exchange factor 1 [Source:HGNC Symbol%3BAcc:HGNC:681]
ENSG00000234602	1.04	1.07	0.57	0.58	0.85	0.85	0.221558230350405	0.140542554573553	0.525682441328546	0.837422210737387	5:55219613-55227315:-	MCIDAS	17;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006275,biological_process regulation of DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016604,cellular_component nuclear body;GO:0030030,biological_process cell projection organization;GO:0042802,molecular_function identical protein binding;GO:0044458,biological_process motile cilium assembly;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060271,biological_process cilium morphogenesis;GO:0098534,biological_process centriole assembly;GO:1903251,biological_process multi-ciliated epithelial cell differentiation;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	multiciliate differentiation and DNA synthesis associated cell cycle protein [Source:HGNC Symbol%3BAcc:HGNC:40050]
ENSG00000171316	9.08	8.85	9.34	8.68	10.12	9.57	-0.0450161192909766	6.39119358804363	0.52585863711465	0.837422210737387	8:60678777-60868028:+	CHD7	61;GO:0000166,molecular_function nucleotide binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001501,biological_process skeletal system development;GO:0001568,biological_process blood vessel development;GO:0001701,biological_process in utero embryonic development;GO:0001974,biological_process blood vessel remodeling;GO:0003007,biological_process heart morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003226,biological_process right ventricular compact myocardium morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0007417,biological_process central nervous system development;GO:0007512,biological_process adult heart development;GO:0007605,biological_process sensory perception of sound;GO:0007626,biological_process locomotory behavior;GO:0007628,biological_process adult walking behavior;GO:0008015,biological_process blood circulation;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0021545,biological_process cranial nerve development;GO:0021553,biological_process olfactory nerve development;GO:0021772,biological_process olfactory bulb development;GO:0030217,biological_process T cell differentiation;GO:0030540,biological_process female genitalia development;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035904,biological_process aorta development;GO:0035909,biological_process aorta morphogenesis;GO:0036302,biological_process atrioventricular canal development;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042048,biological_process olfactory behavior;GO:0042471,biological_process ear morphogenesis;GO:0042472,biological_process inner ear morphogenesis;GO:0043010,biological_process camera-type eye development;GO:0043584,biological_process nose development;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048752,biological_process semicircular canal morphogenesis;GO:0048771,biological_process tissue remodeling;GO:0048806,biological_process genitalia development;GO:0048844,biological_process artery morphogenesis;GO:0050767,biological_process regulation of neurogenesis;GO:0050890,biological_process cognition;GO:0060021,biological_process palate development;GO:0060041,biological_process retina development in camera-type eye;GO:0060123,biological_process regulation of growth hormone secretion;GO:0060173,biological_process limb development;GO:0060324,biological_process face development;GO:0060384,biological_process innervation;GO:0060411,biological_process cardiac septum morphogenesis;GO:0060429,biological_process epithelium development;GO:1990841,molecular_function promoter-specific chromatin binding	NA	chromodomain helicase DNA binding protein 7 [Source:HGNC Symbol%3BAcc:HGNC:20626]
ENSG00000118762	37.40	36.30	37.33	34.26	36.85	37.70	0.0413337525506683	6.73663550992343	0.525961405977977	0.837422210737387	4:88007667-88077777:+	PKD2	112;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001822,biological_process kidney development;GO:0001889,biological_process liver development;GO:0001892,biological_process embryonic placenta development;GO:0001947,biological_process heart looping;GO:0002133,cellular_component polycystin complex;GO:0003127,biological_process detection of nodal flow;GO:0005102,molecular_function receptor binding;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005248,molecular_function voltage-gated sodium channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007050,biological_process cell cycle arrest;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007259,biological_process JAK-STAT cascade;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009925,cellular_component basal plasma membrane;GO:0010628,biological_process positive regulation of gene expression;GO:0015267,molecular_function channel activity;GO:0015271,molecular_function outward rectifier potassium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0021510,biological_process spinal cord development;GO:0021915,biological_process neural tube development;GO:0022843,molecular_function voltage-gated cation channel activity;GO:0030027,cellular_component lamellipodium;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030814,biological_process regulation of cAMP metabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031514,cellular_component motile cilium;GO:0031587,biological_process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0031659,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0031941,cellular_component filamentous actin;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035502,biological_process metanephric part of ureteric bud development;GO:0035725,biological_process sodium ion transmembrane transport;GO:0035904,biological_process aorta development;GO:0036064,cellular_component ciliary basal body;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042805,molecular_function actinin binding;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0042995,cellular_component cell projection;GO:0043398,molecular_function HLH domain binding;GO:0044325,molecular_function ion channel binding;GO:0045180,cellular_component basal cortex;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048763,molecular_function calcium-induced calcium release activity;GO:0050982,biological_process detection of mechanical stimulus;GO:0051117,molecular_function ATPase binding;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051219,molecular_function phosphoprotein binding;GO:0051289,biological_process protein homotetramerization;GO:0051298,biological_process centrosome duplication;GO:0051371,molecular_function muscle alpha-actinin binding;GO:0051393,molecular_function alpha-actinin binding;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060170,cellular_component ciliary membrane;GO:0060315,biological_process negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0060674,biological_process placenta blood vessel development;GO:0061333,biological_process renal tubule morphogenesis;GO:0061441,biological_process renal artery morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071277,biological_process cellular response to calcium ion;GO:0071320,biological_process cellular response to cAMP;GO:0071458,cellular_component integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071464,biological_process cellular response to hydrostatic pressure;GO:0071470,biological_process cellular response to osmotic stress;GO:0071498,biological_process cellular response to fluid shear stress;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:0071805,biological_process potassium ion transmembrane transport;GO:0071910,biological_process determination of liver left/right asymmetry;GO:0072001,biological_process renal system development;GO:0072075,biological_process metanephric mesenchyme development;GO:0072164,biological_process mesonephric tubule development;GO:0072177,biological_process mesonephric duct development;GO:0072208,biological_process metanephric smooth muscle tissue development;GO:0072214,biological_process metanephric cortex development;GO:0072218,biological_process metanephric ascending thin limb development;GO:0072219,biological_process metanephric cortical collecting duct development;GO:0072235,biological_process metanephric distal tubule development;GO:0072284,biological_process metanephric S-shaped body morphogenesis;GO:0072686,cellular_component mitotic spindle;GO:0090279,biological_process regulation of calcium ion import;GO:0097730,cellular_component non-motile cilium;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	polycystin 2%2C transient receptor potential cation channel [Source:HGNC Symbol%3BAcc:HGNC:9009]
ENSG00000256043	11.29	9.03	11.31	9.87	8.98	11.25	0.0923961258615922	3.33846592906295	0.526018438922991	0.837422210737387	4:155924117-155953917:-	CTSO	8;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process	CTSO; cathepsin O [EC:3.4.22.42]; K01374	cathepsin O [Source:HGNC Symbol%3BAcc:HGNC:2542]
ENSG00000117036	5.10	4.46	5.55	5.60	4.70	6.02	-0.0926396187768147	3.06993443911322	0.526037036852608	0.837422210737387	1:157121190-157138474:-	ETV3	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008150,biological_process biological_process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0017053,cellular_component transcriptional repressor complex;GO:0017151,molecular_function DEAD/H-box RNA helicase binding;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0090571,cellular_component RNA polymerase II transcription repressor complex;GO:0097011,biological_process cellular response to granulocyte macrophage colony-stimulating factor stimulus	NA	ETS variant 3 [Source:HGNC Symbol%3BAcc:HGNC:3492]
ENSG00000172671	1.39	1.10	0.94	1.25	1.10	1.50	-0.15104737136609	1.59100370217287	0.526037100831393	0.837422210737387	10:45615500-45672780:-	ZFAND4	2;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger AN1-type containing 4 [Source:HGNC Symbol%3BAcc:HGNC:23504]
ENSG00000141570	5.09	6.26	5.00	4.41	6.04	4.78	0.104732872359362	2.69118343065944	0.526115296393383	0.837422210737387	17:79792131-79801683:-	CBX8	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000790,cellular_component nuclear chromatin;GO:0000792,cellular_component heterochromatin;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016574,biological_process histone ubiquitination;GO:0031519,cellular_component PcG protein complex;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0035064,molecular_function methylated histone binding;GO:0035102,cellular_component PRC1 complex;GO:0045739,biological_process positive regulation of DNA repair;GO:0050790,biological_process regulation of catalytic activity;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0097027,molecular_function ubiquitin-protein transferase activator activity	NA	chromobox 8 [Source:HGNC Symbol%3BAcc:HGNC:15962]
ENSG00000116750	28.32	28.83	30.19	31.50	26.72	26.77	0.0517939550642108	5.54622125166632	0.526227002269108	0.837422210737387	1:193012249-193060080:-	UCHL5	31;GO:0000502,cellular_component proteasome complex;GO:0003723,molecular_function RNA binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0021670,biological_process lateral ventricle development;GO:0030901,biological_process midbrain development;GO:0031011,cellular_component Ino80 complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0048853,biological_process forebrain morphogenesis;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0070628,molecular_function proteasome binding	NA	ubiquitin C-terminal hydrolase L5 [Source:HGNC Symbol%3BAcc:HGNC:19678]
ENSG00000169813	172.68	181.84	173.51	168.93	170.51	178.76	0.0382582292512357	7.76388938386367	0.526237327235923	0.837422210737387	10:43385616-43409166:-	HNRNPF	23;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008134,molecular_function transcription factor binding;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0017025,molecular_function TBP-class protein binding;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043484,biological_process regulation of RNA splicing;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	heterogeneous nuclear ribonucleoprotein F [Source:HGNC Symbol%3BAcc:HGNC:5039]
ENSG00000172922	27.13	26.64	21.98	25.05	26.50	28.23	-0.066772981375419	4.3976496306169	0.526255425876775	0.837422210737387	11:65714895-65720947:-	RNASEH2C	3;GO:0005634,cellular_component nucleus;GO:0006401,biological_process RNA catabolic process;GO:0032299,cellular_component ribonuclease H2 complex	RNASEH2C; ribonuclease H2 subunit C; K10745	ribonuclease H2 subunit C [Source:HGNC Symbol%3BAcc:HGNC:24116]
ENSG00000166685	16.91	17.29	18.92	18.81	17.24	19.28	-0.0466914890545706	5.79367496210151	0.526294349566668	0.837422210737387	17:73192631-73208507:+	COG1	11;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017119,cellular_component Golgi transport complex;GO:0032588,cellular_component trans-Golgi network membrane	NA	component of oligomeric golgi complex 1 [Source:HGNC Symbol%3BAcc:HGNC:6545]
ENSG00000178229	3.34	3.24	3.60	3.87	3.24	3.87	-0.0963720039215937	2.70470954840689	0.526424861915224	0.837422210737387	19:57320508-57330776:+	ZNF543	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 543 [Source:HGNC Symbol%3BAcc:HGNC:25281]
ENSG00000115419	272.87	297.60	253.29	252.93	287.96	262.57	0.0475274273555443	9.22193775403195	0.526476573936978	0.837422210737387	2:190880826-190965552:+	GLS	16;GO:0001967,biological_process suckling behavior;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0004359,molecular_function glutaminase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006537,biological_process glutamate biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0006543,biological_process glutamine catabolic process;GO:0007268,biological_process chemical synaptic transmission;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0014047,biological_process glutamate secretion;GO:0016787,molecular_function hydrolase activity;GO:0051289,biological_process protein homotetramerization	glsA, GLS; glutaminase [EC:3.5.1.2]; K01425	glutaminase [Source:HGNC Symbol%3BAcc:HGNC:4331]
ENSG00000142235	0.51	0.34	0.43	0.40	0.51	0.57	-0.180227843741725	1.15538897265087	0.526483761588219	0.837422210737387	19:48485270-48513189:-	LMTK3	19;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding	NA	lemur tyrosine kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:19295]
ENSG00000163607	11.48	10.90	10.54	12.41	10.94	11.66	-0.075985468318261	3.41774689944326	0.526581548036137	0.83746590627542	3:112990917-113015060:+	GTPBP8	5;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0046872,molecular_function metal ion binding	NA	GTP binding protein 8 (putative) [Source:HGNC Symbol%3BAcc:HGNC:25007]
ENSG00000259332	3.19	3.82	5.49	5.59	3.82	4.76	-0.165834630876876	1.44503247679764	0.526731525952612	0.83746590627542	15:79845149-79923754:-	ST20-MTHFS	7;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0009396,biological_process folic acid-containing compound biosynthetic process;GO:0030272,molecular_function 5-formyltetrahydrofolate cyclo-ligase activity;GO:0035999,biological_process tetrahydrofolate interconversion;GO:0046872,molecular_function metal ion binding	MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]; K01934	ST20-MTHFS readthrough [Source:HGNC Symbol%3BAcc:HGNC:44655]
ENSG00000127989	7.08	7.27	6.70	5.75	7.41	6.76	0.0879206082644138	3.05560530499872	0.526808171794924	0.83746590627542	7:91692007-91880720:-	MTERF1	14;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006393,biological_process termination of mitochondrial transcription;GO:0007005,biological_process mitochondrion organization;GO:0032392,biological_process DNA geometric change;GO:0042645,cellular_component mitochondrial nucleoid	NA	mitochondrial transcription termination factor 1 [Source:HGNC Symbol%3BAcc:HGNC:21463]
ENSG00000090971	7.54	7.19	7.41	6.72	5.25	8.62	0.113862416989119	2.59412447497624	0.526811607286392	0.83746590627542	19:55485003-55487568:+	NAT14	11;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	N-acetyltransferase 14 (putative) [Source:HGNC Symbol%3BAcc:HGNC:28918]
ENSG00000154493	0.59	0.53	0.34	0.52	0.28	0.42	0.255549647210896	0.15682452179516	0.526870360994919	0.83746590627542	10:126424996-126670446:-	C10orf90	10;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0015629,cellular_component actin cytoskeleton;GO:0042826,molecular_function histone deacetylase binding;GO:0051393,molecular_function alpha-actinin binding	NA	chromosome 10 open reading frame 90 [Source:HGNC Symbol%3BAcc:HGNC:26563]
ENSG00000140941	68.53	73.96	73.48	69.93	77.97	76.93	-0.0484647946148266	5.48174586602493	0.526916033836384	0.83746590627542	16:87383994-87404779:+	MAP1LC3B	23;GO:0000045,biological_process autophagosome assembly;GO:0000421,cellular_component autophagosome membrane;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005930,cellular_component axoneme;GO:0006914,biological_process autophagy;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0009267,biological_process cellular response to starvation;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0031090,cellular_component organelle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0061024,biological_process membrane organization;GO:0097352,biological_process autophagosome maturation	MAP1LC; microtubule-associated protein 1 light chain; K10435	microtubule associated protein 1 light chain 3 beta [Source:HGNC Symbol%3BAcc:HGNC:13352]
ENSG00000197747	1593.81	1632.17	1516.03	1489.46	1601.81	1562.46	0.0386855316411436	8.83327406454154	0.527211569077706	0.837828345533422	1:151982914-151994390:-	S100A10	18;GO:0001765,biological_process membrane raft assembly;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0006900,biological_process membrane budding;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044325,molecular_function ion channel binding;GO:0045121,cellular_component membrane raft;GO:0051099,biological_process positive regulation of binding;GO:0051290,biological_process protein heterotetramerization;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0070062,cellular_component extracellular exosome;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	NA	S100 calcium binding protein A10 [Source:HGNC Symbol%3BAcc:HGNC:10487]
ENSG00000110958	332.97	334.67	316.60	340.71	331.47	347.04	-0.0391248818502079	7.36805999142186	0.527356902520414	0.83795202649589	12:56663340-56688408:-	PTGES3	37;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0001516,biological_process prostaglandin biosynthetic process;GO:0003720,molecular_function telomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005978,biological_process glycogen biosynthetic process;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006693,biological_process prostaglandin metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0007004,biological_process telomere maintenance via telomerase;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0016853,molecular_function isomerase activity;GO:0019371,biological_process cyclooxygenase pathway;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0043234,cellular_component protein complex;GO:0043588,biological_process skin development;GO:0050220,molecular_function prostaglandin-E synthase activity;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051879,molecular_function Hsp90 protein binding;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060430,biological_process lung saccule development;GO:0070062,cellular_component extracellular exosome;GO:0070182,molecular_function DNA polymerase binding;GO:0070389,biological_process chaperone cofactor-dependent protein refolding;GO:1900034,biological_process regulation of cellular response to heat;GO:1905323,biological_process telomerase holoenzyme complex assembly	PTGES3; cytosolic prostaglandin-E synthase [EC:5.3.99.3]; K15730	prostaglandin E synthase 3 [Source:HGNC Symbol%3BAcc:HGNC:16049]
ENSG00000093183	38.02	33.15	35.37	37.61	30.83	35.06	0.0566738240554493	5.28453439912612	0.527790763350552	0.838425740307278	3:42547968-42601080:-	SEC22C	13;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031201,cellular_component SNARE complex;GO:0048280,biological_process vesicle fusion with Golgi apparatus	NA	SEC22 homolog C%2C vesicle trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:16828]
ENSG00000165392	6.72	6.10	5.72	5.35	5.67	6.84	0.0654849126960929	4.71442641285303	0.5278305572021	0.838425740307278	8:31033800-31173769:+	WRN	79;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000400,molecular_function four-way junction DNA binding;GO:0000403,molecular_function Y-form DNA binding;GO:0000405,molecular_function bubble DNA binding;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000781,cellular_component chromosome, telomeric region;GO:0001302,biological_process replicative cell aging;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003682,molecular_function chromatin binding;GO:0003824,molecular_function catalytic activity;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006259,biological_process DNA metabolic process;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007420,biological_process brain development;GO:0007568,biological_process aging;GO:0007569,biological_process cell aging;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0008152,biological_process metabolic process;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0009267,biological_process cellular response to starvation;GO:0009378,molecular_function four-way junction helicase activity;GO:0010225,biological_process response to UV-C;GO:0010259,biological_process multicellular organism aging;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030145,molecular_function manganese ion binding;GO:0031297,biological_process replication fork processing;GO:0032066,biological_process nucleolus to nucleoplasm transport;GO:0032389,cellular_component MutLalpha complex;GO:0032403,molecular_function protein complex binding;GO:0032508,biological_process DNA duplex unwinding;GO:0040009,biological_process regulation of growth rate;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043005,cellular_component neuron projection;GO:0043138,molecular_function 3'-5' DNA helicase activity;GO:0043140,molecular_function ATP-dependent 3'-5' DNA helicase activity;GO:0044237,biological_process cellular metabolic process;GO:0044806,biological_process G-quadruplex DNA unwinding;GO:0046872,molecular_function metal ion binding;GO:0051345,biological_process positive regulation of hydrolase activity;GO:0051880,molecular_function G-quadruplex DNA binding;GO:0061749,molecular_function forked DNA-dependent helicase activity;GO:0061820,biological_process telomeric D-loop disassembly;GO:0061821,molecular_function telomeric D-loop binding;GO:0061849,molecular_function telomeric G-quadruplex DNA binding;GO:0070337,molecular_function 3'-flap-structured DNA binding;GO:0071480,biological_process cellular response to gamma radiation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090656,biological_process t-circle formation;GO:0098530,biological_process positive regulation of strand invasion;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1905773,molecular_function 8-hydroxy-2'-deoxyguanosine DNA binding	NA	Werner syndrome RecQ like helicase [Source:HGNC Symbol%3BAcc:HGNC:12791]
ENSG00000150867	46.58	46.27	48.95	48.55	41.53	48.27	0.0473634638131101	5.88354494422639	0.527944190031186	0.838425740307278	10:22534848-22714555:-	PIP4K2A	25;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006644,biological_process phospholipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0010506,biological_process regulation of autophagy;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016307,molecular_function phosphatidylinositol phosphate kinase activity;GO:0016308,molecular_function 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0016309,molecular_function 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035855,biological_process megakaryocyte development;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0052811,molecular_function 1-phosphatidylinositol-3-phosphate 4-kinase activity;GO:2000786,biological_process positive regulation of autophagosome assembly	PIP4K2; 1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]; K00920	phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [Source:HGNC Symbol%3BAcc:HGNC:8997]
ENSG00000175467	34.37	32.06	32.50	32.97	34.86	34.83	-0.0402714284765923	6.36205443991176	0.527950444357169	0.838425740307278	11:65961688-65979828:+	SART1	21;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000481,biological_process maturation of 5S rRNA;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007050,biological_process cell cycle arrest;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0045585,biological_process positive regulation of cytotoxic T cell differentiation;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097193,biological_process intrinsic apoptotic signaling pathway	SART1, HAF, SNU66; U4/U6.U5 tri-snRNP-associated protein 1; K11984	SART1%2C U4/U6.U5 tri-snRNP-associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10538]
ENSG00000214827	3.30	4.76	3.67	4.90	4.49	4.16	-0.218599401613901	0.580401630641125	0.527992750502053	0.838425740307278	X:155061621-155147937:-	MTCP1	7;GO:0005739,cellular_component mitochondrion;GO:0008283,biological_process cell proliferation;GO:0019901,molecular_function protein kinase binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0043234,cellular_component protein complex;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity	MTCP1; mature T-cell proliferation-1 type B1; K16837	mature T-cell proliferation 1 [Source:HGNC Symbol%3BAcc:HGNC:7423]
ENSG00000103811	27.09	29.80	28.70	27.97	31.65	29.73	-0.0533624812857746	5.00982951482379	0.528141194537849	0.83848939095393	15:78921057-78949574:-	CTSH	53;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001656,biological_process metanephros development;GO:0001913,biological_process T cell mediated cytotoxicity;GO:0002250,biological_process adaptive immune response;GO:0002764,biological_process immune response-regulating signaling pathway;GO:0004175,molecular_function endopeptidase activity;GO:0004177,molecular_function aminopeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0010628,biological_process positive regulation of gene expression;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010813,biological_process neuropeptide catabolic process;GO:0010815,biological_process bradykinin catabolic process;GO:0010952,biological_process positive regulation of peptidase activity;GO:0016505,molecular_function peptidase activator activity involved in apoptotic process;GO:0016787,molecular_function hydrolase activity;GO:0019882,biological_process antigen processing and presentation;GO:0030108,molecular_function HLA-A specific activating MHC class I receptor activity;GO:0030335,biological_process positive regulation of cell migration;GO:0031638,biological_process zymogen activation;GO:0031648,biological_process protein destabilization;GO:0032526,biological_process response to retinoic acid;GO:0033619,biological_process membrane protein proteolysis;GO:0034774,cellular_component secretory granule lumen;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043129,biological_process surfactant homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0044267,biological_process cellular protein metabolic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0060448,biological_process dichotomous subdivision of terminal units involved in lung branching;GO:0070062,cellular_component extracellular exosome;GO:0070324,molecular_function thyroid hormone binding;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:0097208,cellular_component alveolar lamellar body;GO:0097486,cellular_component multivesicular body lumen;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	CTSH; cathepsin H [EC:3.4.22.16]; K01366	cathepsin H [Source:HGNC Symbol%3BAcc:HGNC:2535]
ENSG00000028839	30.45	29.04	27.31	30.56	28.01	24.97	0.0688694503347668	4.01913427453108	0.528238728825924	0.83848939095393	6:133952169-133990432:+	TBPL1	17;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001675,biological_process acrosome assembly;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005672,cellular_component transcription factor TFIIA complex;GO:0005737,cellular_component cytoplasm;GO:0006235,biological_process dTTP biosynthetic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0007289,biological_process spermatid nucleus differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein; K03120	TATA-box binding protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:11589]
ENSG00000139977	16.65	13.73	14.57	14.55	16.41	16.71	-0.0662513656462468	4.08556093836343	0.52825805986928	0.83848939095393	14:57390543-57415917:+	NAA30	11;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017196,biological_process N-terminal peptidyl-methionine acetylation;GO:0031417,cellular_component NatC complex	NA	N(alpha)-acetyltransferase 30%2C NatC catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:19844]
ENSG00000157933	7.08	8.36	8.76	7.13	7.71	8.37	0.0671907760035451	4.12062350017057	0.528347097858199	0.83848939095393	1:2228694-2310119:+	SKI	54;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001843,biological_process neural tube closure;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009948,biological_process anterior/posterior axis specification;GO:0010626,biological_process negative regulation of Schwann cell proliferation;GO:0014902,biological_process myotube differentiation;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0017053,cellular_component transcriptional repressor complex;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0021772,biological_process olfactory bulb development;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030509,biological_process BMP signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0031064,biological_process negative regulation of histone deacetylation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032926,biological_process negative regulation of activin receptor signaling pathway;GO:0035019,biological_process somatic stem cell population maintenance;GO:0043010,biological_process camera-type eye development;GO:0043234,cellular_component protein complex;GO:0043388,biological_process positive regulation of DNA binding;GO:0043585,biological_process nose morphogenesis;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046811,molecular_function histone deacetylase inhibitor activity;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0048593,biological_process camera-type eye morphogenesis;GO:0048666,biological_process neuron development;GO:0048741,biological_process skeletal muscle fiber development;GO:0048870,biological_process cell motility;GO:0060021,biological_process palate development;GO:0060041,biological_process retina development in camera-type eye;GO:0060325,biological_process face morphogenesis;GO:0060349,biological_process bone morphogenesis;GO:0060395,biological_process SMAD protein signal transduction;GO:0070207,biological_process protein homotrimerization;GO:0070491,molecular_function repressing transcription factor binding	NA	SKI proto-oncogene [Source:HGNC Symbol%3BAcc:HGNC:10896]
ENSG00000148737	6.99	7.40	8.98	8.59	6.38	7.28	0.0835858786274007	4.09282530995086	0.528479732792852	0.83848939095393	10:112950249-113167678:+	TCF7L2	50;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001568,biological_process blood vessel development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007050,biological_process cell cycle arrest;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0009749,biological_process response to glucose;GO:0010909,biological_process positive regulation of heparan sulfate proteoglycan biosynthetic process;GO:0016055,biological_process Wnt signaling pathway;GO:0016605,cellular_component PML body;GO:0019901,molecular_function protein kinase binding;GO:0031016,biological_process pancreas development;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032092,biological_process positive regulation of protein binding;GO:0032350,biological_process regulation of hormone metabolic process;GO:0032993,cellular_component protein-DNA complex;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0042593,biological_process glucose homeostasis;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043570,biological_process maintenance of DNA repeat elements;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044334,biological_process canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition;GO:0045295,molecular_function gamma-catenin binding;GO:0045444,biological_process fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0048625,biological_process myoblast fate commitment;GO:0048660,biological_process regulation of smooth muscle cell proliferation;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0070016,molecular_function armadillo repeat domain binding;GO:0070369,cellular_component beta-catenin-TCF7L2 complex;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:2000675,biological_process negative regulation of type B pancreatic cell apoptotic process;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	TCF7L2; transcription factor 7-like 2; K04491	transcription factor 7 like 2 [Source:HGNC Symbol%3BAcc:HGNC:11641]
ENSG00000196235	45.72	47.04	44.37	46.03	43.14	45.28	0.0393081608756504	7.20776381212297	0.528487941131196	0.83848939095393	19:39436155-39476670:+	SUPT5H	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006354,biological_process DNA-templated transcription, elongation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0007049,biological_process cell cycle;GO:0010033,biological_process response to organic substance;GO:0016239,biological_process positive regulation of macroautophagy;GO:0019899,molecular_function enzyme binding;GO:0032044,cellular_component DSIF complex;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0032785,biological_process negative regulation of DNA-templated transcription, elongation;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0039692,biological_process single stranded viral RNA replication via double stranded DNA intermediate;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0050434,biological_process positive regulation of viral transcription;GO:1900364,biological_process negative regulation of mRNA polyadenylation	NA	SPT5 homolog%2C DSIF elongation factor subunit [Source:HGNC Symbol%3BAcc:HGNC:11469]
ENSG00000225968	7.11	5.96	7.56	7.26	7.79	6.85	-0.0642814538189272	4.15601082095078	0.528505679112507	0.83848939095393	7:1688118-1747954:+	ELFN1	10;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019902,molecular_function phosphatase binding;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0050808,biological_process synapse organization;GO:0060076,cellular_component excitatory synapse;GO:0070062,cellular_component extracellular exosome	NA	extracellular leucine rich repeat and fibronectin type III domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:33154]
ENSG00000141295	47.29	46.66	51.12	50.19	45.10	46.57	0.0453231636790275	6.03002100222767	0.528619344557524	0.838562546197131	17:47837691-47841333:-	SCRN2	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0006508,biological_process proteolysis;GO:0006887,biological_process exocytosis;GO:0008150,biological_process biological_process;GO:0016805,molecular_function dipeptidase activity;GO:0070062,cellular_component extracellular exosome	NA	secernin 2 [Source:HGNC Symbol%3BAcc:HGNC:30381]
ENSG00000116237	31.84	36.93	26.76	29.26	32.46	29.94	0.0649933297471887	4.83986392974331	0.528884836221765	0.838708704443367	1:6221192-6235972:-	ICMT	13;GO:0003880,molecular_function protein C-terminal carboxyl O-methyltransferase activity;GO:0004671,molecular_function protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006464,biological_process cellular protein modification process;GO:0006481,biological_process C-terminal protein methylation;GO:0006612,biological_process protein targeting to membrane;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0043687,biological_process post-translational protein modification	ICMT, STE14; protein-S-isoprenylcysteine O-methyltransferase [EC:2.1.1.100]; K00587	isoprenylcysteine carboxyl methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:5350]
ENSG00000152503	2.65	2.47	1.84	2.90	2.51	2.21	-0.120706741494031	2.625456439859	0.528911747663577	0.838708704443367	5:115124761-115180546:-	TRIM36	16;GO:0000209,biological_process protein polyubiquitination;GO:0001669,cellular_component acrosomal vesicle;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007340,biological_process acrosome reaction;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle;GO:0070062,cellular_component extracellular exosome	NA	tripartite motif containing 36 [Source:HGNC Symbol%3BAcc:HGNC:16280]
ENSG00000213366	1.38	1.12	1.54	1.66	0.69	1.10	0.251159121330041	0.156453013120361	0.528921748288471	0.838708704443367	1:109668021-109709551:+	GSTM2	27;GO:0004364,molecular_function glutathione transferase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0008152,biological_process metabolic process;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014809,biological_process regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016740,molecular_function transferase activity;GO:0018916,biological_process nitrobenzene metabolic process;GO:0019899,molecular_function enzyme binding;GO:0042178,biological_process xenobiotic catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043295,molecular_function glutathione binding;GO:0043651,biological_process linoleic acid metabolic process;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060315,biological_process negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0060316,biological_process positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0070062,cellular_component extracellular exosome;GO:0070458,biological_process cellular detoxification of nitrogen compound;GO:0071313,biological_process cellular response to caffeine;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase mu 2 [Source:HGNC Symbol%3BAcc:HGNC:4634]
ENSG00000160551	10.61	9.39	10.05	10.20	11.31	9.98	-0.0505995766007153	4.9545160817679	0.52905311571743	0.838708704443367	17:29390463-29551904:+	TAOK1	27;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007062,biological_process sister chromatid cohesion;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007399,biological_process nervous system development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0042981,biological_process regulation of apoptotic process;GO:0046330,biological_process positive regulation of JNK cascade;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0070062,cellular_component extracellular exosome;GO:0097194,biological_process execution phase of apoptosis	TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]; K04429	TAO kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:29259]
ENSG00000177646	29.01	29.73	28.85	28.94	27.64	29.23	0.0399369214192566	5.87730543029551	0.529124344910124	0.838708704443367	3:128879595-128916067:+	ACAD9	12;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0030425,cellular_component dendrite;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	acyl-CoA dehydrogenase family member 9 [Source:HGNC Symbol%3BAcc:HGNC:21497]
ENSG00000196466	3.86	2.57	3.34	3.44	3.33	3.88	-0.0958878178474054	2.84609032833846	0.529171467313613	0.838708704443367	19:12390015-12401271:-	ZNF799	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 799 [Source:HGNC Symbol%3BAcc:HGNC:28071]
ENSG00000164961	47.14	49.36	47.84	44.96	50.06	46.39	0.040934114924776	7.37350793037888	0.529184449625429	0.838708704443367	8:125024259-125091840:-	WASHC5	13;GO:0001556,biological_process oocyte maturation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016197,biological_process endosomal transport;GO:0040038,biological_process polar body extrusion after meiotic divisions;GO:0071203,cellular_component WASH complex;GO:0090306,biological_process spindle assembly involved in meiosis	NA	WASH complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:28984]
ENSG00000185608	66.28	57.22	59.43	64.45	62.83	63.72	-0.0461413114945638	5.27597154787484	0.52933488164283	0.838769230758123	22:19431901-19436075:+	MRPL40	12;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L40 [Source:HGNC Symbol%3BAcc:HGNC:14491]
ENSG00000137393	8.94	6.94	6.88	8.32	9.09	7.27	-0.094444844124936	2.88101771233049	0.529357782466699	0.838769230758123	6:18387349-18468874:+	RNF144B	19;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 144B [Source:HGNC Symbol%3BAcc:HGNC:21578]
ENSG00000084623	186.09	198.29	191.29	200.50	206.14	190.04	-0.0405403495024578	7.57552941985098	0.529478997765192	0.838854218156903	1:32221927-32231604:+	EIF3I	13;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0070062,cellular_component extracellular exosome;GO:0071541,cellular_component eukaryotic translation initiation factor 3 complex, eIF3m	EIF3I; translation initiation factor 3 subunit I; K03246	eukaryotic translation initiation factor 3 subunit I [Source:HGNC Symbol%3BAcc:HGNC:3272]
ENSG00000179348	1.28	1.46	1.23	1.14	1.26	1.12	0.166734418307228	0.9552653115138	0.529587859110739	0.838867533881626	3:128479426-128493185:-	GATA2	68;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001655,biological_process urogenital system development;GO:0001709,biological_process cell fate determination;GO:0001764,biological_process neuron migration;GO:0001892,biological_process embryonic placenta development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006909,biological_process phagocytosis;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0010725,biological_process regulation of primitive erythrocyte differentiation;GO:0021514,biological_process ventral spinal cord interneuron differentiation;GO:0021533,biological_process cell differentiation in hindbrain;GO:0021902,biological_process commitment of neuronal cell to specific neuron type in forebrain;GO:0021954,biological_process central nervous system neuron development;GO:0021983,biological_process pituitary gland development;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0033993,biological_process response to lipid;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035065,biological_process regulation of histone acetylation;GO:0035854,biological_process eosinophil fate commitment;GO:0042472,biological_process inner ear morphogenesis;GO:0043234,cellular_component protein complex;GO:0043306,biological_process positive regulation of mast cell degranulation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045650,biological_process negative regulation of macrophage differentiation;GO:0045654,biological_process positive regulation of megakaryocyte differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048469,biological_process cell maturation;GO:0048663,biological_process neuron fate commitment;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050766,biological_process positive regulation of phagocytosis;GO:0060100,biological_process positive regulation of phagocytosis, engulfment;GO:0060216,biological_process definitive hemopoiesis;GO:0060872,biological_process semicircular canal development;GO:0070345,biological_process negative regulation of fat cell proliferation;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0090102,biological_process cochlea development;GO:0097154,biological_process GABAergic neuron differentiation;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:2000178,biological_process negative regulation of neural precursor cell proliferation;GO:2000977,biological_process regulation of forebrain neuron differentiation	NA	GATA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4171]
ENSG00000143554	6.47	5.89	7.62	6.92	4.99	7.05	0.0911081612120042	4.00067438183535	0.529679327276467	0.838867533881626	1:153774353-153780157:+	SLC27A3	14;GO:0000166,molecular_function nucleotide binding;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0031957,molecular_function very long-chain fatty acid-CoA ligase activity;GO:0031966,cellular_component mitochondrial membrane	SLC27A3, FATP3; solute carrier family 27 (fatty acid transporter), member 3 [EC:6.2.1.-]; K08772	solute carrier family 27 member 3 [Source:HGNC Symbol%3BAcc:HGNC:10997]
ENSG00000142330	9.97	10.62	9.70	9.97	11.08	10.65	-0.0580676954746495	4.53589152155436	0.529753335155675	0.838867533881626	2:240586715-240617705:+	CAPN10	19;GO:0000149,molecular_function SNARE binding;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006921,biological_process cellular component disassembly involved in execution phase of apoptosis;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032388,biological_process positive regulation of intracellular transport;GO:0032869,biological_process cellular response to insulin stimulus;GO:0046326,biological_process positive regulation of glucose import;GO:0097050,biological_process type B pancreatic cell apoptotic process;GO:2000676,biological_process positive regulation of type B pancreatic cell apoptotic process	NA	calpain 10 [Source:HGNC Symbol%3BAcc:HGNC:1477]
ENSG00000112242	9.85	11.36	10.21	8.27	11.00	10.65	0.0757875767644941	3.86424174861057	0.529785486123739	0.838867533881626	6:20401905-20493715:+	E2F3	21;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0070345,biological_process negative regulation of fat cell proliferation;GO:0090575,cellular_component RNA polymerase II transcription factor complex	E2F3; transcription factor E2F3; K06620	E2F transcription factor 3 [Source:HGNC Symbol%3BAcc:HGNC:3115]
ENSG00000115042	43.26	39.16	40.79	38.23	43.07	38.89	0.0511154627737244	5.2634275491251	0.529825301347937	0.838867533881626	2:95402720-95416616:+	FAHD2A	4;GO:0003824,molecular_function catalytic activity;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	fumarylacetoacetate hydrolase domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:24252]
ENSG00000169032	38.18	39.90	41.00	44.04	39.26	40.61	-0.0461909497593157	5.63080859548741	0.530078446346358	0.838930668171643	15:66386816-66492312:+	MAP2K1	70;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001932,biological_process regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004728,molecular_function receptor signaling protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006928,biological_process movement of cell or subcellular component;GO:0006935,biological_process chemotaxis;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007507,biological_process heart development;GO:0008022,molecular_function protein C-terminus binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021697,biological_process cerebellar cortex formation;GO:0030182,biological_process neuron differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030878,biological_process thyroid gland development;GO:0032872,biological_process regulation of stress-activated MAPK cascade;GO:0035897,biological_process proteolysis in other organism;GO:0042981,biological_process regulation of apoptotic process;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0048538,biological_process thymus development;GO:0048679,biological_process regulation of axon regeneration;GO:0048870,biological_process cell motility;GO:0050772,biological_process positive regulation of axonogenesis;GO:0060020,biological_process Bergmann glial cell differentiation;GO:0060324,biological_process face development;GO:0060425,biological_process lung morphogenesis;GO:0060440,biological_process trachea formation;GO:0060502,biological_process epithelial cell proliferation involved in lung morphogenesis;GO:0060674,biological_process placenta blood vessel development;GO:0060711,biological_process labyrinthine layer development;GO:0070062,cellular_component extracellular exosome;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090170,biological_process regulation of Golgi inheritance;GO:0090398,biological_process cellular senescence;GO:1903800,biological_process positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:2000641,biological_process regulation of early endosome to late endosome transport	MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]; K04368	mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:6840]
ENSG00000154511	7.03	8.55	8.75	7.39	9.25	9.39	-0.0916752998462602	3.46261139512126	0.530139364873903	0.838930668171643	1:92832736-92961522:-	FAM69A	4;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 69 member A [Source:HGNC Symbol%3BAcc:HGNC:32213]
ENSG00000105146	1.25	1.42	0.87	1.70	1.05	1.39	-0.230978895028731	0.530322013173954	0.530161900458773	0.838930668171643	19:57230801-57235548:+	AURKC	36;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000793,cellular_component condensed chromosome;GO:0000910,biological_process cytokinesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016570,biological_process histone modification;GO:0016740,molecular_function transferase activity;GO:0030496,cellular_component midbody;GO:0031616,cellular_component spindle pole centrosome;GO:0032133,cellular_component chromosome passenger complex;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035174,molecular_function histone serine kinase activity;GO:0035404,biological_process histone-serine phosphorylation;GO:0048599,biological_process oocyte development;GO:0051233,cellular_component spindle midzone;GO:0051255,biological_process spindle midzone assembly;GO:0051256,biological_process mitotic spindle midzone assembly;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle	NA	aurora kinase C [Source:HGNC Symbol%3BAcc:HGNC:11391]
ENSG00000100578	5.89	6.07	6.05	6.20	6.42	6.15	-0.0480148830302224	4.95203548608309	0.530230845216612	0.838930668171643	14:58427384-58551289:+	KIAA0586	12;GO:0001917,cellular_component photoreceptor inner segment;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007224,biological_process smoothened signaling pathway;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0070201,biological_process regulation of establishment of protein localization	NA	KIAA0586 [Source:HGNC Symbol%3BAcc:HGNC:19960]
ENSG00000205707	48.21	50.18	53.58	55.39	53.76	50.18	-0.0555841342504089	4.45319637516075	0.530264739420203	0.838930668171643	12:25195215-25209645:+	ETFRF1	3;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0022904,biological_process respiratory electron transport chain	NA	electron transfer flavoprotein regulatory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:27052]
ENSG00000100216	87.04	94.44	74.12	88.76	95.60	83.69	-0.0609203152335423	5.22052599082207	0.53033279262445	0.838930668171643	22:38681947-38685421:+	TOMM22	18;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008320,molecular_function protein transmembrane transporter activity;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0045040,biological_process protein import into mitochondrial outer membrane;GO:0071806,biological_process protein transmembrane transport	NA	translocase of outer mitochondrial membrane 22 [Source:HGNC Symbol%3BAcc:HGNC:18002]
ENSG00000147251	5.04	4.60	5.20	4.57	5.51	5.50	-0.0555323325640354	5.00192629148191	0.530338270614911	0.838930668171643	X:118495897-118686163:+	DOCK11	12;GO:0001782,biological_process B cell homeostasis;GO:0002315,biological_process marginal zone B cell differentiation;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007596,biological_process blood coagulation;GO:0017048,molecular_function Rho GTPase binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051491,biological_process positive regulation of filopodium assembly	NA	dedicator of cytokinesis 11 [Source:HGNC Symbol%3BAcc:HGNC:23483]
ENSG00000146232	8.38	7.45	7.80	8.78	7.69	8.63	-0.0700908897882372	3.6292321638033	0.530447125127803	0.838995943452016	6:44258165-44265788:-	NFKBIE	9;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0042942,biological_process D-serine transport;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0048471,cellular_component perinuclear region of cytoplasm	NFKBIE; NF-kappa-B inhibitor epsilon; K05872	NFKB inhibitor epsilon [Source:HGNC Symbol%3BAcc:HGNC:7799]
ENSG00000076321	9.63	7.95	9.06	7.95	8.34	9.39	0.0711453751386567	4.01303056216977	0.530614328809116	0.839066073035631	1:173714940-173786702:+	KLHL20	26;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0007010,biological_process cytoskeleton organization;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016567,biological_process protein ubiquitination;GO:0016605,cellular_component PML body;GO:0019964,molecular_function interferon-gamma binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0035455,biological_process response to interferon-alpha;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:1990390,biological_process protein K33-linked ubiquitination	NA	kelch like family member 20 [Source:HGNC Symbol%3BAcc:HGNC:25056]
ENSG00000108826	48.87	53.46	54.66	48.60	56.03	47.29	0.0583569241223223	4.7303073237499	0.530674917833489	0.839066073035631	17:50367856-50373214:-	MRPL27	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27; K02899	mitochondrial ribosomal protein L27 [Source:HGNC Symbol%3BAcc:HGNC:14483]
ENSG00000065717	1.83	1.40	1.44	1.44	1.61	1.29	0.130383901469934	1.91115859383667	0.530694251140154	0.839066073035631	19:2997637-3047635:-	TLE2	15;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0009887,biological_process organ morphogenesis;GO:0016055,biological_process Wnt signaling pathway;GO:0016604,cellular_component nuclear body;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1904837,biological_process beta-catenin-TCF complex assembly	NA	transducin like enhancer of split 2 [Source:HGNC Symbol%3BAcc:HGNC:11838]
ENSG00000213672	12.09	10.60	12.56	11.13	12.05	11.08	0.0600565501873701	4.73012369605518	0.530768805102107	0.839075004022481	3:48673843-48686364:-	NCKIPSD	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008180,cellular_component COP9 signalosome;GO:0010976,biological_process positive regulation of neuron projection development;GO:0017124,molecular_function SH3 domain binding;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis	NA	NCK interacting protein with SH3 domain [Source:HGNC Symbol%3BAcc:HGNC:15486]
ENSG00000063177	798.13	804.26	789.79	803.43	756.39	791.88	0.0362975054924525	8.97313352964447	0.530835092772782	0.839075004022481	19:48615327-48619536:-	RPL18	19;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L18e, RPL18; large subunit ribosomal protein L18e; K02883	ribosomal protein L18 [Source:HGNC Symbol%3BAcc:HGNC:10310]
ENSG00000119707	55.84	52.07	53.63	51.84	57.03	58.92	-0.0421545206383362	7.15088739331925	0.53094206323887	0.839137233382238	14:73058435-73123898:+	RBM25	12;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0042981,biological_process regulation of apoptotic process	RBM25, S164; RNA-binding protein 25; K12822	RNA binding motif protein 25 [Source:HGNC Symbol%3BAcc:HGNC:23244]
ENSG00000120686	45.46	39.95	43.88	44.46	46.30	45.43	-0.0563127595364655	4.23522112819796	0.531200826734902	0.839343806057923	13:38349848-38363619:+	UFM1	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043066,biological_process negative regulation of apoptotic process;GO:0070062,cellular_component extracellular exosome;GO:0071569,biological_process protein ufmylation;GO:1990592,biological_process protein K69-linked ufmylation	NA	ubiquitin fold modifier 1 [Source:HGNC Symbol%3BAcc:HGNC:20597]
ENSG00000083896	58.12	59.04	57.82	53.87	60.29	57.30	0.0408465138196238	7.02575936245988	0.531208002931688	0.839343806057923	4:68310386-68350089:-	YTHDC1	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:1990247,molecular_function N6-methyladenosine-containing RNA binding	NA	YTH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30626]
ENSG00000198561	70.07	78.14	70.04	75.31	76.33	74.70	-0.0418704441166623	7.7657341723703	0.531371572222447	0.839495395952302	11:57753242-57819546:+	CTNND1	27;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005915,cellular_component zonula adherens;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007155,biological_process cell adhesion;GO:0007420,biological_process brain development;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0034332,biological_process adherens junction organization;GO:0035635,biological_process entry of bacterium into host cell;GO:0043197,cellular_component dendritic spine;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0050839,molecular_function cell adhesion molecule binding;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	CTNND1; catenin (cadherin-associated protein), delta 1; K05690	catenin delta 1 [Source:HGNC Symbol%3BAcc:HGNC:2515]
ENSG00000139675	6.69	5.48	7.21	6.63	6.56	7.91	-0.100122211427611	2.73919784369407	0.531528088432168	0.839562418443266	13:52640785-52643796:+	HNRNPA1L2	11;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0051028,biological_process mRNA transport	HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3; K12741	heterogeneous nuclear ribonucleoprotein A1-like 2 [Source:HGNC Symbol%3BAcc:HGNC:27067]
ENSG00000131238	55.11	54.88	51.54	50.98	54.77	52.43	0.0413961826317764	6.04740199182575	0.531549266619321	0.839562418443266	1:40071460-40097727:-	PPT1	53;GO:0002084,biological_process protein depalmitoylation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005764,cellular_component lysosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006907,biological_process pinocytosis;GO:0007040,biological_process lysosome organization;GO:0007042,biological_process lysosomal lumen acidification;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0007601,biological_process visual perception;GO:0007625,biological_process grooming behavior;GO:0008021,cellular_component synaptic vesicle;GO:0008306,biological_process associative learning;GO:0008344,biological_process adult locomotory behavior;GO:0008474,molecular_function palmitoyl-(protein) hydrolase activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016290,molecular_function palmitoyl-CoA hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0030149,biological_process sphingolipid catabolic process;GO:0030163,biological_process protein catabolic process;GO:0030308,biological_process negative regulation of cell growth;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031579,biological_process membrane raft organization;GO:0032429,biological_process regulation of phospholipase A2 activity;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043202,cellular_component lysosomal lumen;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044257,biological_process cellular protein catabolic process;GO:0044265,biological_process cellular macromolecule catabolic process;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0048549,biological_process positive regulation of pinocytosis;GO:0048666,biological_process neuron development;GO:0050803,biological_process regulation of synapse structure or activity;GO:0050896,biological_process response to stimulus;GO:0051181,biological_process cofactor transport;GO:0051186,biological_process cofactor metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0098599,molecular_function palmitoyl hydrolase activity	PPT; palmitoyl-protein thioesterase [EC:3.1.2.22]; K01074	palmitoyl-protein thioesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:9325]
ENSG00000123268	19.12	19.81	21.66	21.79	19.71	22.21	-0.0611110090259679	4.28313488287078	0.531622154453415	0.839570712879166	12:50763709-50821122:+	ATF1	22;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014070,biological_process response to organic cyclic compound;GO:0032025,biological_process response to cobalt ion;GO:0032403,molecular_function protein complex binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043623,biological_process cellular protein complex assembly;GO:0045740,biological_process positive regulation of DNA replication;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:1990590,cellular_component ATF1-ATF4 transcription factor complex	ATF1; activating transcription factor 1; K09053	activating transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:783]
ENSG00000187951	7.76	8.83	10.20	7.38	8.81	8.95	0.100973746168353	2.82431431992905	0.531770265398696	0.839697787100117	15:30624493-30772993:+	ARHGAP11B	6;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0021987,biological_process cerebral cortex development;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 11B [Source:HGNC Symbol%3BAcc:HGNC:15782]
ENSG00000184840	314.26	334.55	295.45	307.45	315.10	302.32	0.0408298523425504	7.78040411115173	0.531977074859862	0.839917505753685	5:177592157-177596124:+	TMED9	20;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0010638,biological_process positive regulation of organelle organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019905,molecular_function syntaxin binding;GO:0030133,cellular_component transport vesicle;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0048205,biological_process COPI coating of Golgi vesicle;GO:0070062,cellular_component extracellular exosome	NA	transmembrane p24 trafficking protein 9 [Source:HGNC Symbol%3BAcc:HGNC:24878]
ENSG00000113966	7.44	10.07	8.90	8.02	8.12	8.38	0.102005130633008	2.3320020823063	0.532124055225341	0.840042718747571	3:97764520-97801242:+	ARL6	37;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005543,molecular_function phospholipid binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005879,cellular_component axonemal microtubule;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007368,biological_process determination of left/right symmetry;GO:0007420,biological_process brain development;GO:0007601,biological_process visual perception;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0010842,biological_process retina layer formation;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030030,biological_process cell projection organization;GO:0030117,cellular_component membrane coat;GO:0032402,biological_process melanosome transport;GO:0034464,cellular_component BBSome;GO:0042995,cellular_component cell projection;GO:0045444,biological_process fat cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0050896,biological_process response to stimulus;GO:0051258,biological_process protein polymerization;GO:0060271,biological_process cilium morphogenesis;GO:0061512,biological_process protein localization to cilium;GO:0070062,cellular_component extracellular exosome;GO:0097499,biological_process protein localization to nonmotile primary cilium;GO:1903445,biological_process protein transport from ciliary membrane to plasma membrane	NA	ADP ribosylation factor like GTPase 6 [Source:HGNC Symbol%3BAcc:HGNC:13210]
ENSG00000177542	11.18	10.29	13.19	12.78	11.71	12.47	-0.0732072676264345	3.66952704328873	0.532203759565006	0.840061707461905	11:790474-798333:-	SLC25A22	15;GO:0005280,molecular_function hydrogen:amino acid symporter activity;GO:0005313,molecular_function L-glutamate transmembrane transporter activity;GO:0005314,molecular_function high-affinity glutamate transmembrane transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006839,biological_process mitochondrial transport;GO:0015293,molecular_function symporter activity;GO:0015813,biological_process L-glutamate transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0089711,biological_process L-glutamate transmembrane transport	NA	solute carrier family 25 member 22 [Source:HGNC Symbol%3BAcc:HGNC:19954]
ENSG00000165138	13.02	11.34	13.60	12.62	13.07	11.17	0.0603369013705943	5.0629852381802	0.532328810434162	0.840152259875303	9:98731328-98796965:-	ANKS6	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0042995,cellular_component cell projection	NA	ankyrin repeat and sterile alpha motif domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:26724]
ENSG00000128228	5.11	6.92	5.66	5.08	5.72	5.41	0.119009604998105	1.95158193461065	0.532442843046162	0.840225401822021	22:21642260-21644298:+	SDF2L1	14;GO:0004169,molecular_function dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035269,biological_process protein O-linked mannosylation;GO:0042981,biological_process regulation of apoptotic process;GO:0051087,molecular_function chaperone binding;GO:0051117,molecular_function ATPase binding;GO:0051787,molecular_function misfolded protein binding;GO:0071218,biological_process cellular response to misfolded protein;GO:0071712,biological_process ER-associated misfolded protein catabolic process	NA	stromal cell derived factor 2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:10676]
ENSG00000270168	0.79	0.71	0.82	0.74	0.24	0.96	0.264237120563102	0.383261218025272	0.53260365302897	0.840372333170027	16:2988255-3002016:+	AC004233.2	NA	NA	NA
ENSG00000132507	406.21	447.74	361.87	412.26	446.16	409.65	-0.0497361378403133	8.06869911993662	0.532747384100588	0.840492282516599	17:7306998-7312463:+	EIF5A	39;GO:0003723,molecular_function RNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005642,cellular_component annulate lamellae;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006406,biological_process mRNA export from nucleus;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0006452,biological_process translational frameshifting;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006915,biological_process apoptotic process;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007568,biological_process aging;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008612,biological_process peptidyl-lysine modification to peptidyl-hypusine;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017070,molecular_function U6 snRNA binding;GO:0030425,cellular_component dendrite;GO:0043022,molecular_function ribosome binding;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045901,biological_process positive regulation of translational elongation;GO:0045905,biological_process positive regulation of translational termination;GO:0047485,molecular_function protein N-terminus binding;GO:0051028,biological_process mRNA transport;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	NA	eukaryotic translation initiation factor 5A [Source:HGNC Symbol%3BAcc:HGNC:3300]
ENSG00000007202	27.37	31.85	26.08	26.38	30.60	25.79	0.0539896918246913	7.55520151050226	0.533291200037765	0.841243317584036	17:28614439-28645454:-	KIAA0100	2;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region	NA	KIAA0100 [Source:HGNC Symbol%3BAcc:HGNC:28960]
ENSG00000157985	10.04	9.52	10.38	10.72	9.94	10.53	-0.0446566036842062	5.27732492415028	0.533596493723472	0.841616015615881	2:235494088-236131800:+	AGAP1	10;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005525,molecular_function GTP binding;GO:0005543,molecular_function phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11; K12491	ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 1 [Source:HGNC Symbol%3BAcc:HGNC:16922]
ENSG00000118007	13.44	11.35	12.64	12.36	13.51	13.20	-0.0455812886190048	5.6526177443749	0.533663067663949	0.841616015615881	3:136336232-136752403:-	STAG1	19;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0008278,cellular_component cohesin complex;GO:0016363,cellular_component nuclear matrix;GO:0016604,cellular_component nuclear body;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051301,biological_process cell division;GO:0097431,cellular_component mitotic spindle pole	STAG1_2, SCC3, IRR1; cohesin complex subunit SA-1/2; K06671	stromal antigen 1 [Source:HGNC Symbol%3BAcc:HGNC:11354]
ENSG00000053702	1.68	2.04	1.22	1.51	1.44	2.75	-0.225327260732383	0.719453885806942	0.533800776280322	0.841715489562123	12:2825347-2835544:-	NRIP2	7;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis	NA	nuclear receptor interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:23078]
ENSG00000143995	1.83	2.82	2.70	1.62	3.15	1.78	0.171172442765382	1.98511050809088	0.533965455342859	0.841715489562123	2:66433451-66573869:+	MEIS1	25;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007626,biological_process locomotory behavior;GO:0030097,biological_process hemopoiesis;GO:0035855,biological_process megakaryocyte development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048514,biological_process blood vessel morphogenesis;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:0060216,biological_process definitive hemopoiesis	MEIS1; homeobox protein Meis1; K15613	Meis homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:7000]
ENSG00000214706	24.19	23.55	24.44	24.17	21.03	25.06	0.0505410125586996	5.17905130226478	0.534068138627477	0.841715489562123	3:50287731-50292918:-	IFRD2	3;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	interferon related developmental regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:5457]
ENSG00000139734	7.69	8.06	6.88	6.66	7.68	7.56	0.0547856772609323	4.79415869412725	0.53407001097802	0.841715489562123	13:59665582-60163987:-	DIAPH3	9;GO:0003779,molecular_function actin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007283,biological_process spermatogenesis;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0045296,molecular_function cadherin binding	DIAPH3, DRF3; diaphanous 3; K05745	diaphanous related formin 3 [Source:HGNC Symbol%3BAcc:HGNC:15480]
ENSG00000109265	0.23	0.36	0.30	0.20	0.22	0.32	0.218689141977377	0.205521276422125	0.534176161537348	0.841715489562123	4:56049072-56328625:+	KIAA1211	NA	NA	KIAA1211 [Source:HGNC Symbol%3BAcc:HGNC:29219]
ENSG00000174652	24.23	24.66	23.10	22.14	22.84	25.19	0.0460273253737248	5.29215488580741	0.534183663917672	0.841715489562123	19:9412597-9435578:-	ZNF266	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 266 [Source:HGNC Symbol%3BAcc:HGNC:13059]
ENSG00000164818	16.02	14.65	14.68	15.90	16.54	14.85	-0.0458221200697313	5.34683034712525	0.534260496034073	0.841715489562123	7:726700-786475:+	DNAAF5	6;GO:0003341,biological_process cilium movement;GO:0005737,cellular_component cytoplasm;GO:0030030,biological_process cell projection organization;GO:0036158,biological_process outer dynein arm assembly;GO:0036159,biological_process inner dynein arm assembly;GO:0045505,molecular_function dynein intermediate chain binding	NA	dynein axonemal assembly factor 5 [Source:HGNC Symbol%3BAcc:HGNC:26013]
ENSG00000140332	11.63	10.07	12.38	11.91	10.53	10.65	0.0602437280236014	5.01426780601509	0.534268616954803	0.841715489562123	15:70047789-70098176:-	TLE3	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0009887,biological_process organ morphogenesis;GO:0016055,biological_process Wnt signaling pathway;GO:1904837,biological_process beta-catenin-TCF complex assembly	NA	transducin like enhancer of split 3 [Source:HGNC Symbol%3BAcc:HGNC:11839]
ENSG00000139926	14.13	11.02	15.60	13.63	11.53	13.96	0.0774450792316076	4.70162566909396	0.53449431640677	0.841964206796604	14:51489099-51730727:+	FRMD6	11;GO:0003383,biological_process apical constriction;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0031032,biological_process actomyosin structure organization;GO:0032970,biological_process regulation of actin filament-based process;GO:0034613,biological_process cellular protein localization;GO:0043296,cellular_component apical junction complex	FRMD6; FERM domain-containing protein 6; K16822	FERM domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:19839]
ENSG00000105186	17.87	18.09	17.75	18.36	16.61	17.62	0.04144495372412	5.83002295203737	0.534661283780941	0.842120354723108	19:32597006-32676597:-	ANKRD27	29;GO:0000149,molecular_function SNARE binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030133,cellular_component transport vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035544,biological_process negative regulation of SNARE complex assembly;GO:0035646,biological_process endosome to melanosome transport;GO:0042470,cellular_component melanosome;GO:0043005,cellular_component neuron projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045022,biological_process early endosome to late endosome transport;GO:0048812,biological_process neuron projection morphogenesis;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0061024,biological_process membrane organization;GO:0097422,cellular_component tubular endosome;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	ankyrin repeat domain 27 [Source:HGNC Symbol%3BAcc:HGNC:25310]
ENSG00000111640	4944.29	5065.44	5043.66	5321.57	5103.03	5121.91	-0.0347510567878755	12.3444207242402	0.535056846248511	0.842636466947827	12:6533926-6538374:+	GAPDH	49;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004365,molecular_function glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006006,biological_process glucose metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0006417,biological_process regulation of translation;GO:0006915,biological_process apoptotic process;GO:0008017,molecular_function microtubule binding;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016491,molecular_function oxidoreductase activity;GO:0016620,molecular_function oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0016740,molecular_function transferase activity;GO:0017148,biological_process negative regulation of translation;GO:0019828,molecular_function aspartic-type endopeptidase inhibitor activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0031640,biological_process killing of cells of other organism;GO:0031965,cellular_component nuclear membrane;GO:0031982,cellular_component vesicle;GO:0035605,molecular_function peptidyl-cysteine S-nitrosylase activity;GO:0035606,biological_process peptidyl-cysteine S-trans-nitrosylation;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050661,molecular_function NADP binding;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0050821,biological_process protein stabilization;GO:0050832,biological_process defense response to fungus;GO:0051287,molecular_function NAD binding;GO:0051402,biological_process neuron apoptotic process;GO:0051873,biological_process killing by host of symbiont cells;GO:0052501,biological_process positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction;GO:0055114,biological_process oxidation-reduction process;GO:0061621,biological_process canonical glycolysis;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070062,cellular_component extracellular exosome;GO:0071346,biological_process cellular response to interferon-gamma;GO:0097452,cellular_component GAIT complex;GO:0097718,molecular_function disordered domain specific binding	GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]; K00134	glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:4141]
ENSG00000180354	3.49	3.54	5.06	3.83	5.48	4.46	-0.165776269056394	1.38326185379519	0.535195661738336	0.842725919542048	7:30134809-30162762:+	MTURN	1;GO:0007275,biological_process multicellular organism development	NA	maturin%2C neural progenitor differentiation regulator homolog [Source:HGNC Symbol%3BAcc:HGNC:25457]
ENSG00000103423	38.67	37.50	39.68	43.83	37.03	39.79	-0.0456831108382261	5.92335723544278	0.535249427992388	0.842725919542048	16:4425804-4456775:+	DNAJA3	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0006264,biological_process mitochondrial DNA replication;GO:0006457,biological_process protein folding;GO:0006915,biological_process apoptotic process;GO:0006924,biological_process activation-induced cell death of T cells;GO:0007005,biological_process mitochondrion organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007528,biological_process neuromuscular junction development;GO:0007569,biological_process cell aging;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009408,biological_process response to heat;GO:0016020,cellular_component membrane;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0030054,cellular_component cell junction;GO:0030544,molecular_function Hsp70 protein binding;GO:0030695,molecular_function GTPase regulator activity;GO:0031072,molecular_function heat shock protein binding;GO:0031594,cellular_component neuromuscular junction;GO:0033077,biological_process T cell differentiation in thymus;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043069,biological_process negative regulation of programmed cell death;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051082,molecular_function unfolded protein binding;GO:0071340,biological_process skeletal muscle acetylcholine-gated channel clustering	DNAJA3; DnaJ homolog subfamily A member 3; K09504	DnaJ heat shock protein family (Hsp40) member A3 [Source:HGNC Symbol%3BAcc:HGNC:11808]
ENSG00000104660	8.67	8.61	7.86	9.49	8.59	8.58	-0.0739131676977658	3.45730480682813	0.535670455871041	0.843211716080065	8:30095397-30177208:+	LEPROTL1	6;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032511,biological_process late endosome to vacuole transport via multivesicular body sorting pathway;GO:2000009,biological_process negative regulation of protein localization to cell surface	NA	leptin receptor overlapping transcript like 1 [Source:HGNC Symbol%3BAcc:HGNC:6555]
ENSG00000149506	10.15	8.69	11.46	10.44	10.34	11.28	-0.0622788387978618	4.33164613369861	0.535749702037223	0.843211716080065	11:60867561-60875693:+	ZP1	10;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007338,biological_process single fertilization;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030141,cellular_component secretory granule;GO:0031012,cellular_component extracellular matrix	NA	zona pellucida glycoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:13187]
ENSG00000119471	68.32	67.22	67.97	68.24	70.22	72.34	-0.0389231060103007	6.439829782381	0.535819043810402	0.843211716080065	9:112379936-112472410:+	HSDL2	7;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	hydroxysteroid dehydrogenase like 2 [Source:HGNC Symbol%3BAcc:HGNC:18572]
ENSG00000070366	15.27	15.06	14.57	16.78	15.24	14.65	-0.0441043088022736	6.043648660402	0.535838215772407	0.843211716080065	17:2059838-2303771:-	SMG6	31;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000333,cellular_component telomerase catalytic core complex;GO:0000781,cellular_component chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006406,biological_process mRNA export from nucleus;GO:0016787,molecular_function hydrolase activity;GO:0032204,biological_process regulation of telomere maintenance;GO:0032210,biological_process regulation of telomere maintenance via telomerase;GO:0035145,cellular_component exon-exon junction complex;GO:0035303,biological_process regulation of dephosphorylation;GO:0042162,molecular_function telomeric DNA binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043487,biological_process regulation of RNA stability;GO:0046872,molecular_function metal ion binding;GO:0051972,biological_process regulation of telomerase activity;GO:0070034,molecular_function telomerase RNA binding;GO:0070182,molecular_function DNA polymerase binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:1904354,biological_process negative regulation of telomere capping	SMG6, EST1A; protein SMG6 [EC:3.1.-.-]; K11124	SMG6%2C nonsense mediated mRNA decay factor [Source:HGNC Symbol%3BAcc:HGNC:17809]
ENSG00000143771	130.24	124.28	126.10	136.52	124.03	134.67	-0.0417169363702032	5.82257924950498	0.535939619553929	0.843211716080065	1:224356849-224379459:+	CNIH4	10;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031730,molecular_function CCR5 chemokine receptor binding	NA	cornichon family AMPA receptor auxiliary protein 4 [Source:HGNC Symbol%3BAcc:HGNC:25013]
ENSG00000146247	5.96	6.40	5.59	5.54	5.87	6.04	0.0479372024553777	5.01591489033072	0.535965555455708	0.843211716080065	6:78935866-79078236:-	PHIP	17;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007010,biological_process cytoskeleton organization;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008360,biological_process regulation of cell shape;GO:0022604,biological_process regulation of cell morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043568,biological_process positive regulation of insulin-like growth factor receptor signaling pathway;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070062,cellular_component extracellular exosome;GO:0070577,molecular_function lysine-acetylated histone binding;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	pleckstrin homology domain interacting protein [Source:HGNC Symbol%3BAcc:HGNC:15673]
ENSG00000154328	10.02	11.74	10.29	9.50	10.30	10.68	0.0737281755210738	3.39959034372792	0.536213605254578	0.843406472793946	8:11769638-11787346:+	NEIL2	26;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003824,molecular_function catalytic activity;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005876,cellular_component spindle microtubule;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008017,molecular_function microtubule binding;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016799,molecular_function hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0016829,molecular_function lyase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0045008,biological_process depyrimidination;GO:0046872,molecular_function metal ion binding	NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]; K10568	nei like DNA glycosylase 2 [Source:HGNC Symbol%3BAcc:HGNC:18956]
ENSG00000143178	2.79	1.79	2.50	2.85	1.73	1.85	0.167727103996357	1.77820903907738	0.536313770493125	0.843406472793946	1:168281039-168314426:+	TBX19	16;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0009653,biological_process anatomical structure morphogenesis;GO:0021983,biological_process pituitary gland development;GO:0042127,biological_process regulation of cell proliferation;GO:0045165,biological_process cell fate commitment;GO:0045595,biological_process regulation of cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	T-box 19 [Source:HGNC Symbol%3BAcc:HGNC:11596]
ENSG00000151151	4.30	5.13	4.66	4.44	4.86	3.89	0.100097281669998	2.53514669940369	0.53635727744785	0.843406472793946	10:58191516-58267934:-	IPMK	14;GO:0000166,molecular_function nucleotide binding;GO:0000823,molecular_function inositol-1,4,5-trisphosphate 6-kinase activity;GO:0000824,molecular_function inositol tetrakisphosphate 3-kinase activity;GO:0000825,molecular_function inositol tetrakisphosphate 6-kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0008440,molecular_function inositol-1,4,5-trisphosphate 3-kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0047326,molecular_function inositol tetrakisphosphate 5-kinase activity	NA	inositol polyphosphate multikinase [Source:HGNC Symbol%3BAcc:HGNC:20739]
ENSG00000140694	21.81	23.84	24.15	24.68	22.62	25.32	-0.0478651629642757	5.58018394303812	0.536361129157771	0.843406472793946	16:14435700-14632728:-	PARN	28;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006402,biological_process mRNA catabolic process;GO:0007292,biological_process female gamete generation;GO:0009451,biological_process RNA modification;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0043169,molecular_function cation binding;GO:0043488,biological_process regulation of mRNA stability;GO:0046872,molecular_function metal ion binding;GO:0051973,biological_process positive regulation of telomerase activity;GO:0070034,molecular_function telomerase RNA binding;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0090669,biological_process telomerase RNA stabilization;GO:0110008,biological_process ncRNA deadenylation;GO:1904872,biological_process regulation of telomerase RNA localization to Cajal body	PARN, PNLDC1; poly(A)-specific ribonuclease [EC:3.1.13.4]; K01148	poly(A)-specific ribonuclease [Source:HGNC Symbol%3BAcc:HGNC:8609]
ENSG00000159840	69.82	65.76	68.05	71.88	72.49	66.81	-0.039718864248709	7.0583662164987	0.536484297871524	0.843493298224094	7:143381079-143391111:+	ZYX	22;GO:0001725,cellular_component stress fiber;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0016032,biological_process viral process;GO:0030054,cellular_component cell junction;GO:0043149,biological_process stress fiber assembly;GO:0046872,molecular_function metal ion binding;GO:0050727,biological_process regulation of inflammatory response	ZYX; zyxin; K06273	zyxin [Source:HGNC Symbol%3BAcc:HGNC:13200]
ENSG00000162869	17.22	19.21	18.96	19.47	19.57	18.54	-0.0466156117247881	5.54552904224096	0.536667665102647	0.843657285786697	2:48440597-48515391:+	PPP1R21	2;GO:0016020,cellular_component membrane;GO:0019902,molecular_function phosphatase binding	NA	protein phosphatase 1 regulatory subunit 21 [Source:HGNC Symbol%3BAcc:HGNC:30595]
ENSG00000137478	15.03	13.91	14.77	14.57	13.59	14.54	0.0483913398926264	5.07204673399892	0.536724529594582	0.843657285786697	11:72836744-73142261:-	FCHSD2	5;GO:0005515,molecular_function protein binding;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0030833,biological_process regulation of actin filament polymerization;GO:0031594,cellular_component neuromuscular junction;GO:0055037,cellular_component recycling endosome	NA	FCH and double SH3 domains 2 [Source:HGNC Symbol%3BAcc:HGNC:29114]
ENSG00000196367	12.71	14.64	12.72	12.06	14.40	12.53	0.0501921321318157	7.26420168216065	0.536856553676568	0.843757964141205	7:98877932-99013243:+	TRRAP	25;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000125,cellular_component PCAF complex;GO:0000812,cellular_component Swr1 complex;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0030914,cellular_component STAGA complex;GO:0033276,cellular_component transcription factor TFTC complex;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:1904837,biological_process beta-catenin-TCF complex assembly	TRRAP; transformation/transcription domain-associated protein; K08874	transformation/transcription domain associated protein [Source:HGNC Symbol%3BAcc:HGNC:12347]
ENSG00000136816	24.93	25.58	23.38	23.71	24.24	23.85	0.0499877291261926	4.63836201793062	0.536933993287583	0.843772839432683	9:129803152-129811281:+	TOR1B	18;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006986,biological_process response to unfolded protein;GO:0007029,biological_process endoplasmic reticulum organization;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0031965,cellular_component nuclear membrane;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051260,biological_process protein homooligomerization;GO:0070062,cellular_component extracellular exosome;GO:0071763,biological_process nuclear membrane organization	NA	torsin family 1 member B [Source:HGNC Symbol%3BAcc:HGNC:11995]
ENSG00000231924	2.79	2.92	1.98	2.74	3.05	2.67	-0.136755802376851	1.90731750793363	0.537069307175124	0.843878646830989	19:42866463-42879822:-	PSG1	4;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0007565,biological_process female pregnancy;GO:0050900,biological_process leukocyte migration	NA	pregnancy specific beta-1-glycoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:9514]
ENSG00000185761	5.96	4.39	4.92	5.00	5.22	4.18	0.110122794211281	2.90803533774229	0.537220218977791	0.844003729763082	19:1505017-1513604:-	ADAMTSL5	5;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0008270,molecular_function zinc ion binding	NA	ADAMTS like 5 [Source:HGNC Symbol%3BAcc:HGNC:27912]
ENSG00000157326	39.39	40.03	37.86	35.77	36.83	41.57	0.0478947964762914	5.12432112269873	0.537284900716013	0.844003729763082	14:23953585-23969279:+	DHRS4	19;GO:0000253,molecular_function 3-keto sterol reductase activity;GO:0004090,molecular_function carbonyl reductase (NADPH) activity;GO:0005102,molecular_function receptor binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006066,biological_process alcohol metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016655,molecular_function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018455,molecular_function alcohol dehydrogenase [NAD(P)+] activity;GO:0042180,biological_process cellular ketone metabolic process;GO:0042572,biological_process retinol metabolic process;GO:0051262,biological_process protein tetramerization;GO:0052650,molecular_function NADP-retinol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	DHRS4; dehydrogenase/reductase SDR family member 4 [EC:1.1.-.-]; K11147	dehydrogenase/reductase 4 [Source:HGNC Symbol%3BAcc:HGNC:16985]
ENSG00000162804	1.13	0.64	0.96	0.91	0.96	1.17	-0.123716457624057	2.18584453842415	0.537407064209974	0.844051799405162	2:240998837-241095568:+	SNED1	4;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0007160,biological_process cell-matrix adhesion;GO:0070062,cellular_component extracellular exosome	NA	sushi%2C nidogen and EGF like domains 1 [Source:HGNC Symbol%3BAcc:HGNC:24696]
ENSG00000104356	9.49	9.61	8.34	9.41	9.97	9.29	-0.0540952845368886	4.8519801302111	0.537451496213518	0.844051799405162	8:98117296-98159834:+	POP1	21;GO:0000171,molecular_function ribonuclease MRP activity;GO:0000172,cellular_component ribonuclease MRP complex;GO:0001682,biological_process tRNA 5'-leader removal;GO:0003723,molecular_function RNA binding;GO:0004526,molecular_function ribonuclease P activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005655,cellular_component nucleolar ribonuclease P complex;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0006396,biological_process RNA processing;GO:0008033,biological_process tRNA processing;GO:0016078,biological_process tRNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030681,cellular_component multimeric ribonuclease P complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]; K01164	POP1 homolog%2C ribonuclease P/MRP subunit [Source:HGNC Symbol%3BAcc:HGNC:30129]
ENSG00000164751	62.91	62.56	58.08	64.89	63.91	61.63	-0.0421448008556379	5.83812092941373	0.537671996488059	0.844127216237005	8:76980257-77001044:-	PEX2	18;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0006635,biological_process fatty acid beta-oxidation;GO:0007031,biological_process peroxisome organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016558,biological_process protein import into peroxisome matrix;GO:0016567,biological_process protein ubiquitination;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0031648,biological_process protein destabilization;GO:0046872,molecular_function metal ion binding;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0061630,molecular_function ubiquitin protein ligase activity	PEX2, PXMP3; peroxin-2; K06664	peroxisomal biogenesis factor 2 [Source:HGNC Symbol%3BAcc:HGNC:9717]
ENSG00000196628	2.11	2.06	2.17	1.75	2.10	2.14	0.0939211020504083	2.78984397597307	0.537685470877225	0.844127216237005	18:55222330-55664787:-	TCF4	37;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001011,molecular_function transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001087,molecular_function transcription factor activity, TFIIB-class binding;GO:0001093,molecular_function TFIIB-class transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0010629,biological_process negative regulation of gene expression;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030154,biological_process cell differentiation;GO:0032993,cellular_component protein-DNA complex;GO:0042118,biological_process endothelial cell activation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043621,molecular_function protein self-association;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0065004,biological_process protein-DNA complex assembly;GO:0070888,molecular_function E-box binding;GO:1900746,biological_process regulation of vascular endothelial growth factor signaling pathway	NA	transcription factor 4 [Source:HGNC Symbol%3BAcc:HGNC:11634]
ENSG00000197779	1.28	0.89	0.94	1.17	0.67	0.93	0.18960426808679	1.11446466196172	0.537764200324338	0.844127216237005	X:47836901-48002561:+	ZNF81	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 81 [Source:HGNC Symbol%3BAcc:HGNC:13156]
ENSG00000090776	7.48	7.18	8.79	9.45	6.94	8.94	-0.0952789188493911	3.10924369421981	0.537815110750109	0.844127216237005	X:68828996-68842147:+	EFNB1	22;GO:0001755,biological_process neural crest cell migration;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0009880,biological_process embryonic pattern specification;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0031295,biological_process T cell costimulation;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0070062,cellular_component extracellular exosome	EFNB; ephrin-B; K05463	ephrin B1 [Source:HGNC Symbol%3BAcc:HGNC:3226]
ENSG00000162600	15.10	15.50	15.78	15.06	17.40	16.05	-0.0532872376441431	4.72797143387574	0.537891981357543	0.844127216237005	1:58415383-58546802:-	OMA1	22;GO:0002024,biological_process diet induced thermogenesis;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006006,biological_process glucose metabolic process;GO:0006508,biological_process proteolysis;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006950,biological_process response to stress;GO:0007005,biological_process mitochondrion organization;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0010637,biological_process negative regulation of mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0034982,biological_process mitochondrial protein processing;GO:0042407,biological_process cristae formation;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0097009,biological_process energy homeostasis	NA	OMA1 zinc metallopeptidase [Source:HGNC Symbol%3BAcc:HGNC:29661]
ENSG00000121989	4.63	4.84	6.03	4.96	5.27	6.49	-0.0966753773244857	3.07931855163913	0.538511782019822	0.844127216237005	2:147844516-147930826:+	ACVR2A	53;GO:0000166,molecular_function nucleotide binding;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0007368,biological_process determination of left/right symmetry;GO:0007498,biological_process mesoderm development;GO:0008584,biological_process male gonad development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009966,biological_process regulation of signal transduction;GO:0009986,cellular_component cell surface;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017002,molecular_function activin-activated receptor activity;GO:0019838,molecular_function growth factor binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030165,molecular_function PDZ domain binding;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0030510,biological_process regulation of BMP signaling pathway;GO:0032924,biological_process activin receptor signaling pathway;GO:0032927,biological_process positive regulation of activin receptor signaling pathway;GO:0034673,cellular_component inhibin-betaglycan-ActRII complex;GO:0034711,molecular_function inhibin binding;GO:0042713,biological_process sperm ejaculation;GO:0043084,biological_process penile erection;GO:0043235,cellular_component receptor complex;GO:0043621,molecular_function protein self-association;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048185,molecular_function activin binding;GO:0048706,biological_process embryonic skeletal system development;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0060011,biological_process Sertoli cell proliferation;GO:0071773,biological_process cellular response to BMP stimulus;GO:0098821,molecular_function BMP receptor activity	ACVR2A; activin receptor type-2A [EC:2.7.11.30]; K04670	activin A receptor type 2A [Source:HGNC Symbol%3BAcc:HGNC:173]
ENSG00000102908	6.41	5.75	6.54	6.08	6.29	5.86	0.0540992552895123	4.88007265760477	0.538567477378259	0.844127216237005	16:69565093-69704666:+	NFAT5	21;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001816,biological_process cytokine production;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006970,biological_process response to osmotic stress;GO:0007165,biological_process signal transduction;GO:0007588,biological_process excretion;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070884,biological_process regulation of calcineurin-NFAT signaling cascade	NA	nuclear factor of activated T-cells 5 [Source:HGNC Symbol%3BAcc:HGNC:7774]
ENSG00000162241	1.00	0.97	0.97	0.91	1.31	1.28	-0.237925955300427	0.281945892833552	0.538633380565076	0.844127216237005	11:65375191-65383701:-	SLC25A45	8;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 45 [Source:HGNC Symbol%3BAcc:HGNC:27442]
ENSG00000100580	3.98	4.90	4.83	4.76	3.11	4.69	0.127743508036373	2.14085979859961	0.538653368174181	0.844127216237005	14:77335020-77377109:-	TMED8	2;GO:0006810,biological_process transport;GO:0016021,cellular_component integral component of membrane	NA	transmembrane p24 trafficking protein family member 8 [Source:HGNC Symbol%3BAcc:HGNC:18633]
ENSG00000064703	8.88	8.81	8.58	8.60	8.32	8.59	0.0526938765881308	4.44506992274314	0.538697542563412	0.844127216237005	1:111755244-111768016:+	DDX20	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008380,biological_process RNA splicing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019904,molecular_function protein domain specific binding;GO:0030674,molecular_function protein binding, bridging;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0042826,molecular_function histone deacetylase binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048477,biological_process oogenesis;GO:0050810,biological_process regulation of steroid biosynthetic process;GO:0051170,biological_process nuclear import;GO:0070491,molecular_function repressing transcription factor binding;GO:0090571,cellular_component RNA polymerase II transcription repressor complex;GO:0097504,cellular_component Gemini of coiled bodies	DDX20, GEMIN3; ATP-dependent RNA helicase DDX20 [EC:3.6.4.13]; K13131	DEAD-box helicase 20 [Source:HGNC Symbol%3BAcc:HGNC:2743]
ENSG00000198231	70.97	67.89	69.91	68.95	72.59	74.53	-0.0374438731239213	7.66853452106947	0.5387233623683	0.844127216237005	17:63773602-63819317:+	DDX42	20;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008104,biological_process protein localization;GO:0010501,biological_process RNA secondary structure unwinding;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0042981,biological_process regulation of apoptotic process	DDX42, SF3B125; ATP-dependent RNA helicase DDX42 [EC:3.6.4.13]; K12835	DEAD-box helicase 42 [Source:HGNC Symbol%3BAcc:HGNC:18676]
ENSG00000148290	31.39	29.31	28.79	29.20	26.71	31.02	0.0537680112849292	4.73584181701301	0.538736587966691	0.844127216237005	9:133351754-133356676:-	SURF1	14;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0006119,biological_process oxidative phosphorylation;GO:0006754,biological_process ATP biosynthetic process;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly;GO:0055114,biological_process oxidation-reduction process;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	SURF1%2C cytochrome c oxidase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:11474]
ENSG00000039123	17.94	19.03	18.85	19.37	19.67	18.82	-0.0410585517070586	5.90699341734623	0.538788015014977	0.844127216237005	5:55307759-55425581:+	SKIV2L2	21;GO:0000166,molecular_function nucleotide binding;GO:0000178,cellular_component exosome (RNase complex);GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0006401,biological_process RNA catabolic process;GO:0008380,biological_process RNA splicing;GO:0016787,molecular_function hydrolase activity;GO:0071013,cellular_component catalytic step 2 spliceosome	MTR4, SKIV2L2; ATP-dependent RNA helicase DOB1 [EC:3.6.4.13]; K12598	Ski2 like RNA helicase 2 [Source:HGNC Symbol%3BAcc:HGNC:18734]
ENSG00000104897	54.49	54.03	56.36	57.55	55.36	57.89	-0.0386275214408547	6.28730068539508	0.538998283135691	0.844127216237005	19:2236503-2248679:+	SF3A2	18;GO:0000389,biological_process mRNA 3'-splice site recognition;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016607,cellular_component nuclear speck;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0046872,molecular_function metal ion binding;GO:0071004,cellular_component U2-type prespliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	SF3A2, SAP62; splicing factor 3A subunit 2; K12826	splicing factor 3a subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:10766]
ENSG00000109686	8.65	7.77	8.16	6.86	8.50	8.44	0.0607621087400155	4.73726406396459	0.539012234833348	0.844127216237005	4:151102750-151325632:-	SH3D19	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0022604,biological_process regulation of cell morphogenesis;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis	NA	SH3 domain containing 19 [Source:HGNC Symbol%3BAcc:HGNC:30418]
ENSG00000102977	11.24	10.30	9.65	11.78	9.89	11.24	-0.0651391750260131	4.13998983499862	0.539035699775251	0.844127216237005	16:67657511-67660815:-	ACD	28;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001501,biological_process skeletal system development;GO:0001655,biological_process urogenital system development;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006886,biological_process intracellular protein transport;GO:0016233,biological_process telomere capping;GO:0016604,cellular_component nuclear body;GO:0030326,biological_process embryonic limb morphogenesis;GO:0031848,biological_process protection from non-homologous end joining at telomere;GO:0032202,biological_process telomere assembly;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0035282,biological_process segmentation;GO:0042162,molecular_function telomeric DNA binding;GO:0044877,molecular_function macromolecular complex binding;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060381,biological_process positive regulation of single-stranded telomeric DNA binding;GO:0070182,molecular_function DNA polymerase binding;GO:0070187,cellular_component telosome;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0070200,biological_process establishment of protein localization to telomere	NA	ACD%2C shelterin complex subunit and telomerase recruitment factor [Source:HGNC Symbol%3BAcc:HGNC:25070]
ENSG00000072195	0.12	0.13	0.16	0.09	0.14	0.13	0.208520772818307	0.628047072609191	0.539049374823508	0.844127216237005	2:219434845-219498287:+	SPEG	14;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006468,biological_process protein phosphorylation;GO:0007517,biological_process muscle organ development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0042692,biological_process muscle cell differentiation	NA	SPEG complex locus [Source:HGNC Symbol%3BAcc:HGNC:16901]
ENSG00000101574	15.47	19.56	15.82	16.09	16.82	16.03	0.057655032687708	4.60654650347951	0.539072853166376	0.844127216237005	18:2537524-2571509:-	METTL4	8;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0009007,molecular_function site-specific DNA-methyltransferase (adenine-specific) activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0032775,biological_process DNA methylation on adenine	NA	methyltransferase like 4 [Source:HGNC Symbol%3BAcc:HGNC:24726]
ENSG00000101331	2.10	3.40	1.98	2.62	3.14	2.46	-0.14971999807292	2.19607528020934	0.539078479701488	0.844127216237005	20:32010449-32032180:+	CCM2L	10;GO:0003209,biological_process cardiac atrium morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0032091,biological_process negative regulation of protein binding;GO:0034111,biological_process negative regulation of homotypic cell-cell adhesion;GO:0042060,biological_process wound healing;GO:0055017,biological_process cardiac muscle tissue growth;GO:0090271,biological_process positive regulation of fibroblast growth factor production	NA	CCM2 like scaffolding protein [Source:HGNC Symbol%3BAcc:HGNC:16153]
ENSG00000204815	3.35	2.69	3.56	4.18	2.92	3.40	-0.106227130974981	2.80371694628205	0.539093091906455	0.844127216237005	17:41930634-41965651:+	TTC25	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0042995,cellular_component cell projection	NA	tetratricopeptide repeat domain 25 [Source:HGNC Symbol%3BAcc:HGNC:25280]
ENSG00000168014	3.68	4.06	3.96	3.64	4.63	4.02	-0.060354403235425	4.92817608224584	0.539131477904945	0.844127216237005	11:74012713-74171210:-	C2CD3	26;GO:0001701,biological_process in utero embryonic development;GO:0001947,biological_process heart looping;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007389,biological_process pattern specification process;GO:0007420,biological_process brain development;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0016485,biological_process protein processing;GO:0021915,biological_process neural tube development;GO:0021997,biological_process neural plate axis specification;GO:0030030,biological_process cell projection organization;GO:0030162,biological_process regulation of proteolysis;GO:0030326,biological_process embryonic limb morphogenesis;GO:0034451,cellular_component centriolar satellite;GO:0036064,cellular_component ciliary basal body;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0061511,biological_process centriole elongation;GO:0071539,biological_process protein localization to centrosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1905515,biological_process non-motile cilium assembly	NA	C2 calcium dependent domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:24564]
ENSG00000139629	1.48	1.08	1.46	0.80	1.42	1.39	0.174823314242983	1.34731737255609	0.539229134096352	0.844127216237005	12:51351246-51392867:-	GALNT6	13;GO:0000139,cellular_component Golgi membrane;GO:0004653,molecular_function polypeptide N-acetylgalactosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]; K00710	polypeptide N-acetylgalactosaminyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:4128]
ENSG00000196263	3.72	3.71	3.53	4.23	3.15	2.92	0.103400201793534	2.76436624137279	0.539362036133851	0.844127216237005	19:56507842-56530221:+	ZNF471	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 471 [Source:HGNC Symbol%3BAcc:HGNC:23226]
ENSG00000213988	2.58	3.69	2.19	3.83	2.50	3.01	-0.147695911073059	2.53266882603669	0.539364592779301	0.844127216237005	19:20077993-20127076:+	ZNF90	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 90 [Source:HGNC Symbol%3BAcc:HGNC:13165]
ENSG00000066117	26.05	26.21	25.16	25.55	28.49	26.46	-0.0452517181577729	5.39938825699219	0.539418140586204	0.844127216237005	12:50084971-50100712:+	SMARCD1	19;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0032947,molecular_function protein complex scaffold;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0071398,biological_process cellular response to fatty acid;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:0090544,cellular_component BAF-type complex	SMARCD; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D; K11650	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily d%2C member 1 [Source:HGNC Symbol%3BAcc:HGNC:11106]
ENSG00000180530	19.29	18.62	18.54	19.48	18.32	20.81	-0.042335218167964	6.06269568366623	0.539431240095435	0.844127216237005	21:14961234-15065936:-	NRIP1	32;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001543,biological_process ovarian follicle rupture;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007623,biological_process circadian rhythm;GO:0016607,cellular_component nuclear speck;GO:0019915,biological_process lipid storage;GO:0030331,molecular_function estrogen receptor binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030728,biological_process ovulation;GO:0032922,biological_process circadian regulation of gene expression;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0042826,molecular_function histone deacetylase binding;GO:0042974,molecular_function retinoic acid receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046965,molecular_function retinoid X receptor binding;GO:0048511,biological_process rhythmic process;GO:0050681,molecular_function androgen receptor binding;GO:0071392,biological_process cellular response to estradiol stimulus	NA	nuclear receptor interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8001]
ENSG00000180346	7.98	6.98	7.52	7.99	7.08	8.88	-0.0756153537858786	3.63135396022229	0.539542121018536	0.844127216237005	4:89111499-89114899:+	TIGD2	3;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	tigger transposable element derived 2 [Source:HGNC Symbol%3BAcc:HGNC:18333]
ENSG00000067646	2.44	2.94	2.39	2.93	2.84	2.55	-0.0974308759615115	2.71563540047447	0.539602359438185	0.844127216237005	Y:2935280-2982506:+	ZFY	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein%2C Y-linked [Source:HGNC Symbol%3BAcc:HGNC:12870]
ENSG00000213064	19.86	21.10	24.53	20.59	21.17	20.80	0.0794123854768612	3.3787456391253	0.539609782959246	0.844127216237005	1:168225937-168253025:+	SFT2D2	8;GO:0003674,molecular_function molecular_function;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0070062,cellular_component extracellular exosome	NA	SFT2 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25140]
ENSG00000174718	7.34	7.24	7.50	7.10	7.11	7.41	0.0434061682901185	5.26111603748219	0.539636686383912	0.844127216237005	12:31959369-31993107:+	KIAA1551	NA	NA	KIAA1551 [Source:HGNC Symbol%3BAcc:HGNC:25559]
ENSG00000184640	94.50	91.54	100.76	102.08	95.22	99.81	-0.038768370239202	8.12912423212219	0.539657141556336	0.844127216237005	17:77280568-77500596:+	SEPT9	18;GO:0000166,molecular_function nucleotide binding;GO:0001725,cellular_component stress fiber;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005930,cellular_component axoneme;GO:0007049,biological_process cell cycle;GO:0015629,cellular_component actin cytoskeleton;GO:0031105,cellular_component septin complex;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051291,biological_process protein heterooligomerization;GO:0051301,biological_process cell division;GO:0097730,cellular_component non-motile cilium;GO:1902857,biological_process positive regulation of nonmotile primary cilium assembly	SEPT3_9_12; septin 3/9/12; K16938	septin 9 [Source:HGNC Symbol%3BAcc:HGNC:7323]
ENSG00000156860	19.75	19.99	20.35	20.78	20.74	20.71	-0.0388975711621836	5.91011701692427	0.539724612962141	0.844127216237005	16:30658430-30670814:+	FBRS	NA	NA	fibrosin [Source:HGNC Symbol%3BAcc:HGNC:20442]
ENSG00000184508	15.72	16.74	16.86	15.69	15.27	16.23	0.0721562911227244	3.31807306363889	0.539743632906881	0.844127216237005	15:90929963-90932569:-	HDDC3	4;GO:0005515,molecular_function protein binding;GO:0008893,molecular_function guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]; K01139	HD domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:30522]
ENSG00000143850	12.69	14.99	13.38	13.55	15.68	13.62	-0.053346720757298	5.75386175745461	0.539869825862655	0.844163272647576	1:204218850-204377665:-	PLEKHA6	NA	NA	pleckstrin homology domain containing A6 [Source:HGNC Symbol%3BAcc:HGNC:17053]
ENSG00000184227	2.68	2.12	2.33	2.49	1.50	2.51	0.152595082488025	1.60324079220614	0.539902700519545	0.844163272647576	14:73537113-73543794:+	ACOT1	11;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006637,biological_process acyl-CoA metabolic process;GO:0016290,molecular_function palmitoyl-CoA hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0016790,molecular_function thiolester hydrolase activity;GO:0047617,molecular_function acyl-CoA hydrolase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0102991,molecular_function myristoyl-CoA hydrolase activity	ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]; K01068	acyl-CoA thioesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:33128]
ENSG00000206053	247.07	241.37	243.13	245.87	256.58	253.85	-0.036022541115275	7.76673163838285	0.540085125206271	0.84434214851202	16:1678255-1702280:+	JPT2	4;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane	NA	Jupiter microtubule associated homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:14137]
ENSG00000130726	78.83	83.24	76.42	76.18	80.40	77.46	0.0382602464107101	7.66887954696888	0.540317213552945	0.844598611236961	19:58544090-58550722:+	TRIM28	55;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001701,biological_process in utero embryonic development;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005719,cellular_component nuclear euchromatin;GO:0005720,cellular_component nuclear heterochromatin;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007265,biological_process Ras protein signal transduction;GO:0007566,biological_process embryo implantation;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0016925,biological_process protein sumoylation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035851,molecular_function Krueppel-associated box domain binding;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043045,biological_process DNA methylation involved in embryo development;GO:0043388,biological_process positive regulation of DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045087,biological_process innate immune response;GO:0045739,biological_process positive regulation of DNA repair;GO:0045869,biological_process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051259,biological_process protein oligomerization;GO:0060028,biological_process convergent extension involved in axis elongation;GO:0060669,biological_process embryonic placenta morphogenesis;GO:0070087,molecular_function chromo shadow domain binding;GO:0090309,biological_process positive regulation of methylation-dependent chromatin silencing;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1901536,biological_process negative regulation of DNA demethylation;GO:1902187,biological_process negative regulation of viral release from host cell;GO:1990841,molecular_function promoter-specific chromatin binding;GO:2000653,biological_process regulation of genetic imprinting	NA	tripartite motif containing 28 [Source:HGNC Symbol%3BAcc:HGNC:16384]
ENSG00000171823	6.59	7.32	9.45	9.55	7.38	8.30	-0.0977238713033705	3.36892667138392	0.540589279435129	0.844819500015376	12:1565992-1594165:-	FBXL14	7;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 14 [Source:HGNC Symbol%3BAcc:HGNC:28624]
ENSG00000089847	0.77	0.69	0.86	0.72	0.65	0.77	0.141328652651455	1.59762166936846	0.540594641796675	0.844819500015376	19:4183353-4224814:+	ANKRD24	NA	NA	ankyrin repeat domain 24 [Source:HGNC Symbol%3BAcc:HGNC:29424]
ENSG00000033327	2.05	2.59	2.32	2.36	1.98	2.12	0.107903337753211	2.2222547378624	0.540692078033178	0.844847822373922	11:78215296-78418348:-	GAB2	15;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007411,biological_process axon guidance;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0030316,biological_process osteoclast differentiation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043306,biological_process positive regulation of mast cell degranulation;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0048015,biological_process phosphatidylinositol-mediated signaling	GAB2; growth factor receptor bound protein 2-associated protein 2; K08091	GRB2 associated binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:14458]
ENSG00000227057	30.64	29.04	30.04	30.93	31.29	30.82	-0.0386276530958589	5.80625909218157	0.540853478491005	0.844847822373922	6:33279107-33289527:-	WDR46	10;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030686,cellular_component 90S preribosome;GO:0032040,cellular_component small-subunit processome;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	WD repeat domain 46 [Source:HGNC Symbol%3BAcc:HGNC:13923]
ENSG00000176946	20.30	22.73	21.03	20.70	23.35	22.65	-0.0504560064219387	5.31161026569743	0.540884324296071	0.844847822373922	2:241584404-241637449:-	THAP4	3;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:23187]
ENSG00000177311	74.88	73.12	76.13	74.85	80.09	76.85	-0.0364332890243293	8.09149130751199	0.54088501123061	0.844847822373922	3:141324212-141449792:+	ZBTB38	17;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006275,biological_process regulation of DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008327,molecular_function methyl-CpG binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0072562,cellular_component blood microparticle	NA	zinc finger and BTB domain containing 38 [Source:HGNC Symbol%3BAcc:HGNC:26636]
ENSG00000114541	7.93	10.01	7.48	6.91	9.60	7.71	0.0767274003160881	4.76630276066119	0.541067206319953	0.845026073483842	3:69169989-69542583:-	FRMD4B	5;GO:0001726,cellular_component ruffle;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0090162,biological_process establishment of epithelial cell polarity	NA	FERM domain containing 4B [Source:HGNC Symbol%3BAcc:HGNC:24886]
ENSG00000167112	30.09	30.89	30.83	30.01	31.93	33.71	-0.0490824497093669	4.96350706787129	0.541145374031192	0.845041832664384	9:128305160-128322742:-	TRUB2	8;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity	NA	TruB pseudouridine synthase family member 2 [Source:HGNC Symbol%3BAcc:HGNC:17170]
ENSG00000176170	11.92	9.61	15.87	16.29	9.82	14.72	-0.110806144386069	4.26453339024004	0.541292277557155	0.845053631925357	17:76376583-76387860:+	SPHK1	47;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001568,biological_process blood vessel development;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006670,biological_process sphingosine metabolic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007420,biological_process brain development;GO:0008152,biological_process metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008481,molecular_function sphinganine kinase activity;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017050,molecular_function D-erythro-sphingosine kinase activity;GO:0019722,biological_process calcium-mediated signaling;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032651,biological_process regulation of interleukin-1 beta production;GO:0035556,biological_process intracellular signal transduction;GO:0038036,molecular_function sphingosine-1-phosphate receptor activity;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046512,biological_process sphingosine biosynthetic process;GO:0046521,biological_process sphingoid catabolic process;GO:0046834,biological_process lipid phosphorylation;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051721,molecular_function protein phosphatase 2A binding	SPHK; sphingosine kinase [EC:2.7.1.91]; K04718	sphingosine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:11240]
ENSG00000122033	27.86	22.23	20.56	25.05	26.28	23.61	-0.0681967289154374	4.3533725561155	0.541333896351746	0.845053631925357	13:27435642-27450591:-	MTIF3	10;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0032790,biological_process ribosome disassembly;GO:0043022,molecular_function ribosome binding;GO:0043024,molecular_function ribosomal small subunit binding;GO:0070124,biological_process mitochondrial translational initiation	NA	mitochondrial translational initiation factor 3 [Source:HGNC Symbol%3BAcc:HGNC:29788]
ENSG00000163807	35.77	37.85	39.83	39.06	32.50	37.75	0.0636000802344366	4.1133975076932	0.541357164349508	0.845053631925357	3:44737660-44761662:-	KIAA1143	1;GO:0005515,molecular_function protein binding	NA	KIAA1143 [Source:HGNC Symbol%3BAcc:HGNC:29198]
ENSG00000182087	63.78	61.34	70.30	65.33	60.05	65.85	0.0439631604362297	7.07927198586816	0.541444342958674	0.845083443876024	19:1009647-1021179:-	TMEM259	7;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:1901215,biological_process negative regulation of neuron death;GO:1904294,biological_process positive regulation of ERAD pathway	NA	transmembrane protein 259 [Source:HGNC Symbol%3BAcc:HGNC:17039]
ENSG00000143621	140.68	162.06	137.66	152.55	158.18	147.17	-0.0459449640238294	7.5213984732946	0.54156511441509	0.845149484638822	1:153661787-153671048:-	ILF2	20;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006955,biological_process immune response;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	interleukin enhancer binding factor 2 [Source:HGNC Symbol%3BAcc:HGNC:6037]
ENSG00000148110	35.04	33.75	34.29	34.30	32.65	34.15	0.0407348937593928	5.7038692733309	0.541622826899366	0.845149484638822	9:94374550-94461042:+	MFSD14B	5;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	major facilitator superfamily domain containing 14B [Source:HGNC Symbol%3BAcc:HGNC:23376]
ENSG00000164180	6.60	6.08	6.33	7.13	6.39	6.65	-0.0692845166459458	3.53224917537889	0.541803789879919	0.845290096019611	5:88189632-88269476:-	TMEM161B	4;GO:0003676,molecular_function nucleic acid binding;GO:0015074,biological_process DNA integration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 161B [Source:HGNC Symbol%3BAcc:HGNC:28483]
ENSG00000113558	306.39	302.47	276.49	289.95	322.21	306.44	-0.0417161952274949	7.52551991115735	0.541950566070161	0.845290096019611	5:134148934-134177038:-	SKP1	33;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008013,molecular_function beta-catenin binding;GO:0010265,biological_process SCF complex assembly;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019904,molecular_function protein domain specific binding;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031467,cellular_component Cul7-RING ubiquitin ligase complex;GO:0031519,cellular_component PcG protein complex;GO:0035518,biological_process histone H2A monoubiquitination;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051457,biological_process maintenance of protein location in nucleus;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0097602,molecular_function cullin family protein binding	SKP1, CBF3D; S-phase kinase-associated protein 1; K03094	S-phase kinase associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10899]
ENSG00000171051	5.92	5.92	4.91	6.92	5.42	5.76	-0.104177497530222	2.64295422160402	0.542037656127823	0.845290096019611	19:51745171-51804110:-	FPR1	28;GO:0000187,biological_process activation of MAPK activity;GO:0002430,biological_process complement receptor mediated signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0004875,molecular_function complement receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004982,molecular_function N-formyl peptide receptor activity;GO:0005124,molecular_function scavenger receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007263,biological_process nitric oxide mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030667,cellular_component secretory granule membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0050786,molecular_function RAGE receptor binding;GO:0050900,biological_process leukocyte migration;GO:0060326,biological_process cell chemotaxis;GO:0101003,cellular_component ficolin-1-rich granule membrane	FPR1; formyl peptide receptor 1; K04172	formyl peptide receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:3826]
ENSG00000214447	1.22	0.83	1.42	0.95	1.12	1.04	0.197548555850521	1.21981248001147	0.542038639037391	0.845290096019611	17:44899711-44905390:+	FAM187A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 187 member A [Source:HGNC Symbol%3BAcc:HGNC:35153]
ENSG00000164022	68.66	66.18	66.30	73.39	64.03	71.50	-0.0427611173612948	6.11085832768331	0.54210725721051	0.845290096019611	4:106315543-106349226:+	AIMP1	35;GO:0000049,molecular_function tRNA binding;GO:0001525,biological_process angiogenesis;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0003723,molecular_function RNA binding;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006915,biological_process apoptotic process;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0009611,biological_process response to wounding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0017102,cellular_component methionyl glutamyl tRNA synthetase complex;GO:0030133,cellular_component transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042803,molecular_function protein homodimerization activity;GO:0048514,biological_process blood vessel morphogenesis;GO:0050900,biological_process leukocyte migration;GO:0051020,molecular_function GTPase binding;GO:0051607,biological_process defense response to virus	NA	aminoacyl tRNA synthetase complex interacting multifunctional protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10648]
ENSG00000172992	39.13	36.27	36.00	34.68	35.35	38.36	0.0525474350023082	4.67637253568849	0.542121522147114	0.845290096019611	17:45023339-45061109:-	DCAKD	7;GO:0000166,molecular_function nucleotide binding;GO:0004140,molecular_function dephospho-CoA kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0016020,cellular_component membrane;GO:0016310,biological_process phosphorylation	NA	dephospho-CoA kinase domain containing [Source:HGNC Symbol%3BAcc:HGNC:26238]
ENSG00000112297	32.26	33.55	34.41	32.91	31.47	34.03	0.0379000674443504	7.74491392110724	0.542431580803489	0.845584976124241	6:106360807-106571978:+	CRYBG1	4;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0030246,molecular_function carbohydrate binding	NA	crystallin beta-gamma domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:356]
ENSG00000049883	6.34	4.93	6.26	5.59	5.30	5.81	0.0950843805776331	2.88270982013782	0.54251312728055	0.845584976124241	5:72320366-72368395:+	PTCD2	11;GO:0001822,biological_process kidney development;GO:0001889,biological_process liver development;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0006397,biological_process mRNA processing;GO:0007005,biological_process mitochondrion organization;GO:0007507,biological_process heart development;GO:0010468,biological_process regulation of gene expression;GO:0048747,biological_process muscle fiber development;GO:0050684,biological_process regulation of mRNA processing;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis	NA	pentatricopeptide repeat domain 2 [Source:HGNC Symbol%3BAcc:HGNC:25734]
ENSG00000221968	70.16	60.06	71.66	74.60	66.32	69.65	-0.0464101843819779	6.55367719475417	0.542515004419033	0.845584976124241	11:61873518-61892051:-	FADS3	11;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	fatty acid desaturase 3 [Source:HGNC Symbol%3BAcc:HGNC:3576]
ENSG00000092020	20.35	19.09	22.10	19.46	19.03	21.43	0.0530243151650264	4.99249392600555	0.543102761863741	0.846394800127384	14:35085466-35122517:-	PPP2R3C	18;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001782,biological_process B cell homeostasis;GO:0002759,biological_process regulation of antimicrobial humoral response;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0030865,biological_process cortical cytoskeleton organization;GO:0032147,biological_process activation of protein kinase activity;GO:0043029,biological_process T cell homeostasis;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048536,biological_process spleen development;GO:0050864,biological_process regulation of B cell activation;GO:0051900,biological_process regulation of mitochondrial depolarization	PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''; K11583	protein phosphatase 2 regulatory subunit B''gamma [Source:HGNC Symbol%3BAcc:HGNC:17485]
ENSG00000256235	135.76	131.14	128.80	147.66	131.88	134.39	-0.0522966148488242	4.61268250571417	0.543328879419099	0.846508387672038	5:150777945-150796734:+	SMIM3	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:30248]
ENSG00000142676	1403.53	1339.46	1366.11	1444.44	1380.79	1418.59	-0.0347018342618291	9.60266749554773	0.54334907626965	0.846508387672038	1:23691778-23696425:+	RPL11	40;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006605,biological_process protein targeting;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008097,molecular_function 5S rRNA binding;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034504,biological_process protein localization to nucleus;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0043234,cellular_component protein complex;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1901798,biological_process positive regulation of signal transduction by p53 class mediator;GO:1902255,biological_process positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:1904667,biological_process negative regulation of ubiquitin protein ligase activity;GO:1990948,molecular_function ubiquitin ligase inhibitor activity;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000435,biological_process negative regulation of protein neddylation	RP-L11e, RPL11; large subunit ribosomal protein L11e; K02868	ribosomal protein L11 [Source:HGNC Symbol%3BAcc:HGNC:10301]
ENSG00000134668	1.25	0.77	1.19	1.12	0.52	1.25	0.182232704919114	2.03432655006385	0.54338023305976	0.846508387672038	1:31790421-31816051:-	SPOCD1	2;GO:0006351,biological_process transcription, DNA-templated;GO:0010923,biological_process negative regulation of phosphatase activity	NA	SPOC domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26338]
ENSG00000112651	33.89	31.67	33.49	37.87	30.80	34.96	-0.0514729156183913	5.14892633950856	0.543548777869872	0.84666469816774	6:43054028-43059806:-	MRPL2	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L2, MRPL2, rplB; large subunit ribosomal protein L2; K02886	mitochondrial ribosomal protein L2 [Source:HGNC Symbol%3BAcc:HGNC:14056]
ENSG00000151612	7.68	6.61	6.76	7.22	8.15	6.78	-0.0558601511180567	4.75168983277599	0.543669388249708	0.846746313217518	4:145757626-145938635:-	ZNF827	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 827 [Source:HGNC Symbol%3BAcc:HGNC:27193]
ENSG00000189144	2.08	1.91	2.43	2.21	2.17	2.59	-0.101210320525207	2.41341444851383	0.544269407370052	0.847365259786048	19:37735832-37817300:-	ZNF573	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 573 [Source:HGNC Symbol%3BAcc:HGNC:26420]
ENSG00000100319	28.11	25.11	30.59	32.59	28.70	27.71	-0.0665985388192946	3.89635074496212	0.544325298877017	0.847365259786048	22:29730955-29767011:-	ZMAT5	10;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0046872,molecular_function metal ion binding	NA	zinc finger matrin-type 5 [Source:HGNC Symbol%3BAcc:HGNC:28046]
ENSG00000075151	29.04	28.53	29.25	27.97	29.23	28.15	0.0368231618220725	7.33584790980319	0.544330231549767	0.847365259786048	1:20806291-21176888:-	EIF4G3	11;GO:0000339,molecular_function RNA cap binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0016032,biological_process viral process;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex	EIF4G; translation initiation factor 4G; K03260	eukaryotic translation initiation factor 4 gamma 3 [Source:HGNC Symbol%3BAcc:HGNC:3298]
ENSG00000108523	69.06	76.30	78.63	73.21	76.04	69.76	0.0434658508463574	6.38026242706118	0.544346967091087	0.847365259786048	17:4940007-4945222:+	RNF167	12;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0045786,biological_process negative regulation of cell cycle;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 167 [Source:HGNC Symbol%3BAcc:HGNC:24544]
ENSG00000163382	58.84	61.84	56.68	58.06	58.16	57.46	0.0393990757003404	5.77725647711209	0.544408116232477	0.847365259786048	1:156591761-156594299:+	NAXE	24;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0006734,biological_process NADH metabolic process;GO:0006739,biological_process NADP metabolic process;GO:0008150,biological_process biological_process;GO:0016853,molecular_function isomerase activity;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044297,cellular_component cell body;GO:0046496,biological_process nicotinamide nucleotide metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0052856,molecular_function NADHX epimerase activity;GO:0052857,molecular_function NADPHX epimerase activity;GO:0070062,cellular_component extracellular exosome	NA	NAD(P)HX epimerase [Source:HGNC Symbol%3BAcc:HGNC:18453]
ENSG00000177380	1.30	1.23	1.25	1.13	1.16	1.24	0.112766574027453	2.17688565279329	0.544499330402823	0.847400976465678	19:49119388-49151026:+	PPFIA3	10;GO:0001669,cellular_component acrosomal vesicle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007269,biological_process neurotransmitter secretion;GO:0014047,biological_process glutamate secretion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:0048786,cellular_component presynaptic active zone;GO:0098875,cellular_component epididymosome	NA	PTPRF interacting protein alpha 3 [Source:HGNC Symbol%3BAcc:HGNC:9247]
ENSG00000117407	15.75	13.18	18.78	17.08	12.12	15.95	0.0981970742628202	3.61178111187413	0.544654193415769	0.847510273312992	1:43933319-43937241:+	ARTN	15;GO:0000165,biological_process MAPK cascade;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0007165,biological_process signal transduction;GO:0007405,biological_process neuroblast proliferation;GO:0007411,biological_process axon guidance;GO:0007422,biological_process peripheral nervous system development;GO:0008083,molecular_function growth factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050930,biological_process induction of positive chemotaxis;GO:0061146,biological_process Peyer's patch morphogenesis;GO:0097021,biological_process lymphocyte migration into lymphoid organs	NA	artemin [Source:HGNC Symbol%3BAcc:HGNC:727]
ENSG00000114805	3.13	3.37	2.69	2.96	3.11	2.75	0.0657960752213568	3.97164758095802	0.54470611137445	0.847510273312992	3:155375579-155745067:-	PLCH1	18;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0035556,biological_process intracellular signal transduction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050429,molecular_function calcium-dependent phospholipase C activity	NA	phospholipase C eta 1 [Source:HGNC Symbol%3BAcc:HGNC:29185]
ENSG00000122707	6.52	6.46	6.82	6.50	6.98	7.29	-0.0562527725484294	4.31356066413708	0.544887714374225	0.847617839028531	9:36036432-36124451:+	RECK	17;GO:0001955,biological_process blood vessel maturation;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007566,biological_process embryo implantation;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0010466,biological_process negative regulation of peptidase activity;GO:0016020,cellular_component membrane;GO:0030198,biological_process extracellular matrix organization;GO:0030336,biological_process negative regulation of cell migration;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031225,cellular_component anchored component of membrane;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:1904684,biological_process negative regulation of metalloendopeptidase activity	RECK, ST15; reversion-inducing-cysteine-rich protein with kazal motifs; K17461	reversion inducing cysteine rich protein with kazal motifs [Source:HGNC Symbol%3BAcc:HGNC:11345]
ENSG00000121067	37.00	39.16	40.17	41.11	40.05	39.56	-0.0426918489428071	5.56162365533442	0.544911814665889	0.847617839028531	17:49598883-49678234:-	SPOP	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042593,biological_process glucose homeostasis;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:2000676,biological_process positive regulation of type B pancreatic cell apoptotic process	SPOP; speckle-type POZ protein; K10523	speckle type BTB/POZ protein [Source:HGNC Symbol%3BAcc:HGNC:11254]
ENSG00000107949	39.82	41.03	42.64	43.96	41.39	42.80	-0.0419345674351112	5.60988192876935	0.545308516950015	0.848064665185704	10:125823545-125853695:+	BCCIP	23;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000922,cellular_component spindle pole;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0019207,molecular_function kinase regulator activity;GO:0019908,cellular_component nuclear cyclin-dependent protein kinase holoenzyme complex;GO:0034453,biological_process microtubule anchoring;GO:0061101,biological_process neuroendocrine cell differentiation;GO:0090307,biological_process mitotic spindle assembly;GO:0097431,cellular_component mitotic spindle pole	NA	BRCA2 and CDKN1A interacting protein [Source:HGNC Symbol%3BAcc:HGNC:978]
ENSG00000188760	1.70	1.60	2.20	1.15	1.60	2.15	0.18027079707832	1.34753742751268	0.545342681259141	0.848064665185704	2:219543662-219550595:+	TMEM198	7;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0031410,cellular_component cytoplasmic vesicle;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	transmembrane protein 198 [Source:HGNC Symbol%3BAcc:HGNC:33704]
ENSG00000095574	9.94	9.43	8.67	9.59	9.41	7.83	0.077354878373675	3.54070165601348	0.545505658947309	0.848064665185704	10:122990805-123008817:-	IKZF5	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0019904,molecular_function protein domain specific binding;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0051291,biological_process protein heterooligomerization	NA	IKAROS family zinc finger 5 [Source:HGNC Symbol%3BAcc:HGNC:14283]
ENSG00000062650	23.70	22.70	22.95	24.35	22.56	25.00	-0.0401534565387808	6.39714964179898	0.54558013731977	0.848064665185704	10:86435255-86521815:-	WAPL	26;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0000795,cellular_component synaptonemal complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0008156,biological_process negative regulation of DNA replication;GO:0008278,cellular_component cohesin complex;GO:0009636,biological_process response to toxic substance;GO:0016032,biological_process viral process;GO:0035562,biological_process negative regulation of chromatin binding;GO:0045132,biological_process meiotic chromosome segregation;GO:0045875,biological_process negative regulation of sister chromatid cohesion;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051301,biological_process cell division;GO:0051983,biological_process regulation of chromosome segregation;GO:0060623,biological_process regulation of chromosome condensation;GO:0071168,biological_process protein localization to chromatin;GO:0071922,biological_process regulation of cohesin loading	NA	WAPL cohesin release factor [Source:HGNC Symbol%3BAcc:HGNC:23293]
ENSG00000133247	7.64	6.34	6.69	6.81	5.86	7.10	0.0827308065098331	3.252172990246	0.545587563523447	0.848064665185704	19:55339852-55348120:+	KMT5C	17;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005720,cellular_component nuclear heterochromatin;GO:0005721,cellular_component pericentric heterochromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034773,biological_process histone H4-K20 trimethylation;GO:0042799,molecular_function histone methyltransferase activity (H4-K20 specific)	SUV420H; [histone H4]-N-methyl-L-lysine20 N-methyltransferase [EC:2.1.1.362]; K11429	lysine methyltransferase 5C [Source:HGNC Symbol%3BAcc:HGNC:28405]
ENSG00000172954	10.50	8.26	9.02	9.23	9.49	10.77	-0.0667871273625043	3.9307699178116	0.545657435965197	0.848064665185704	2:30447225-30644225:+	LCLAT1	17;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0007275,biological_process multicellular organism development;GO:0008152,biological_process metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0035965,biological_process cardiolipin acyl-chain remodeling	LCLAT1, AGPAT8; lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]; K13513	lysocardiolipin acyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:26756]
ENSG00000198722	1.97	2.31	1.90	1.94	2.45	2.11	-0.0643541186869415	5.03096059378779	0.545721760477856	0.848064665185704	9:35161991-35405338:+	UNC13B	42;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0007528,biological_process neuromuscular junction development;GO:0010808,biological_process positive regulation of synaptic vesicle priming;GO:0014047,biological_process glutamate secretion;GO:0016020,cellular_component membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016081,biological_process synaptic vesicle docking;GO:0016082,biological_process synaptic vesicle priming;GO:0017137,molecular_function Rab GTPase binding;GO:0019992,molecular_function diacylglycerol binding;GO:0030054,cellular_component cell junction;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031594,cellular_component neuromuscular junction;GO:0031914,biological_process negative regulation of synaptic plasticity;GO:0032009,cellular_component early phagosome;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043195,cellular_component terminal bouton;GO:0044305,cellular_component calyx of Held;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0048172,biological_process regulation of short-term neuronal synaptic plasticity;GO:0048786,cellular_component presynaptic active zone;GO:0050714,biological_process positive regulation of protein secretion;GO:0060384,biological_process innervation;GO:0071333,biological_process cellular response to glucose stimulus;GO:0090382,biological_process phagosome maturation;GO:0097151,biological_process positive regulation of inhibitory postsynaptic potential;GO:0097470,cellular_component ribbon synapse;GO:0098793,cellular_component presynapse;GO:0099525,biological_process presynaptic dense core vesicle exocytosis;GO:1900426,biological_process positive regulation of defense response to bacterium	UNC13A_B_C, MUNC13; protein unc-13 A/B/C; K15293	unc-13 homolog B [Source:HGNC Symbol%3BAcc:HGNC:12566]
ENSG00000133641	20.76	17.75	15.93	16.36	16.87	19.06	0.0710213734375611	4.17762917739151	0.5458139321711	0.848064665185704	12:88033845-88050160:+	C12orf29	1;GO:0002244,biological_process hematopoietic progenitor cell differentiation	NA	chromosome 12 open reading frame 29 [Source:HGNC Symbol%3BAcc:HGNC:25322]
ENSG00000110107	66.99	71.88	67.98	72.28	71.14	70.69	-0.0395102244860339	6.75141841264827	0.545851323122794	0.848064665185704	11:60890729-60906588:-	PRPF19	41;GO:0000209,biological_process protein polyubiquitination;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000245,biological_process spliceosomal complex assembly;GO:0000349,biological_process generation of catalytic spliceosome for first transesterification step;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0001833,biological_process inner cell mass cell proliferation;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006397,biological_process mRNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008380,biological_process RNA splicing;GO:0008610,biological_process lipid biosynthetic process;GO:0010498,biological_process proteasomal protein catabolic process;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0034613,biological_process cellular protein localization;GO:0035861,cellular_component site of double-strand break;GO:0042802,molecular_function identical protein binding;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0071006,cellular_component U2-type catalytic step 1 spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0072422,biological_process signal transduction involved in DNA damage checkpoint	PRPF19, PRP19; pre-mRNA-processing factor 19 [EC:2.3.2.27]; K10599	pre-mRNA processing factor 19 [Source:HGNC Symbol%3BAcc:HGNC:17896]
ENSG00000171703	26.63	22.29	25.82	24.17	22.22	26.19	0.0594233112588242	4.77573498927164	0.545882274618044	0.848064665185704	20:64049835-64072347:+	TCEA2	14;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006354,biological_process DNA-templated transcription, elongation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006414,biological_process translational elongation;GO:0008023,cellular_component transcription elongation factor complex;GO:0008270,molecular_function zinc ion binding;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	transcription elongation factor A2 [Source:HGNC Symbol%3BAcc:HGNC:11614]
ENSG00000142396	59.96	52.28	61.84	61.27	57.42	63.86	-0.0508573674230981	4.77629087684616	0.546448578618673	0.848817087138145	19:58305318-58315663:+	AC020915.1	NA	NA	NA
ENSG00000136444	11.50	11.32	13.43	10.22	13.16	11.45	0.0735245966425818	3.98926157813073	0.546503356191739	0.848817087138145	17:50478799-50485975:+	RSAD1	10;GO:0003824,molecular_function catalytic activity;GO:0004109,molecular_function coproporphyrinogen oxidase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process	NA	radical S-adenosyl methionine domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25634]
ENSG00000175548	5.54	7.76	5.77	7.03	5.79	4.97	0.100917279797189	3.14484931308772	0.546603843678179	0.84886694752624	12:38316577-38329728:+	ALG10B	12;GO:0004583,molecular_function dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0060050,biological_process positive regulation of protein glycosylation;GO:1901980,biological_process positive regulation of inward rectifier potassium channel activity	ALG10; alpha-1,2-glucosyltransferase [EC:2.4.1.256]; K03850	ALG10B%2C alpha-1%2C2-glucosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:31088]
ENSG00000140931	40.46	36.72	39.51	44.34	35.13	43.11	-0.0572145040531653	4.85668610081318	0.546772932683839	0.848876221524375	16:66603873-66613892:+	CMTM3	9;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006935,biological_process chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0050861,biological_process positive regulation of B cell receptor signaling pathway	NA	CKLF like MARVEL transmembrane domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:19174]
ENSG00000143786	8.83	6.77	10.58	11.54	7.58	9.96	-0.125305859467212	2.20693740727858	0.546810803695581	0.848876221524375	1:224434659-224740549:+	CNIH3	19;GO:0000139,cellular_component Golgi membrane;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016247,molecular_function channel regulator activity;GO:0030054,cellular_component cell junction;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0042391,biological_process regulation of membrane potential;GO:0043198,cellular_component dendritic shaft;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048208,biological_process COPII vesicle coating;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	NA	cornichon family AMPA receptor auxiliary protein 3 [Source:HGNC Symbol%3BAcc:HGNC:26802]
ENSG00000121210	3.77	4.02	3.93	4.23	4.24	3.81	-0.0576780790258587	4.28332295002268	0.546920816297279	0.848876221524375	4:153466345-153636711:+	TMEM131L	8;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0033088,biological_process negative regulation of immature T cell proliferation in thymus;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	transmembrane 131 like [Source:HGNC Symbol%3BAcc:HGNC:29146]
ENSG00000095397	2.31	2.05	2.55	2.02	2.30	2.23	0.0966705104371618	2.80223356822958	0.546922639250369	0.848876221524375	9:114402079-114505450:-	WHRN	27;GO:0001895,biological_process retina homeostasis;GO:0001917,cellular_component photoreceptor inner segment;GO:0002141,cellular_component stereocilia ankle link;GO:0002142,cellular_component stereocilia ankle link complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005884,cellular_component actin filament;GO:0005929,cellular_component cilium;GO:0007605,biological_process sensory perception of sound;GO:0010628,biological_process positive regulation of gene expression;GO:0021694,biological_process cerebellar Purkinje cell layer formation;GO:0030426,cellular_component growth cone;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0032420,cellular_component stereocilium;GO:0032421,cellular_component stereocilium bundle;GO:0032426,cellular_component stereocilium tip;GO:0036064,cellular_component ciliary basal body;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0045184,biological_process establishment of protein localization;GO:0046982,molecular_function protein heterodimerization activity;GO:0050953,biological_process sensory perception of light stimulus;GO:0060088,biological_process auditory receptor cell stereocilium organization;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:1990075,cellular_component periciliary membrane compartment;GO:1990227,biological_process paranodal junction maintenance;GO:1990696,cellular_component USH2 complex	NA	whirlin [Source:HGNC Symbol%3BAcc:HGNC:16361]
ENSG00000106336	0.34	0.60	0.57	0.66	0.22	0.38	0.265519810641333	0.124203740693176	0.546995894423846	0.848876221524375	7:100583981-100601117:+	FBXO24	4;GO:0000151,cellular_component ubiquitin ligase complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0016567,biological_process protein ubiquitination	NA	F-box protein 24 [Source:HGNC Symbol%3BAcc:HGNC:13595]
ENSG00000160352	4.22	4.61	5.40	4.47	5.24	5.49	-0.0850610249433136	3.25299882746589	0.547020131795172	0.848876221524375	19:21082158-21125270:+	ZNF714	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 714 [Source:HGNC Symbol%3BAcc:HGNC:27124]
ENSG00000102226	26.50	24.28	25.55	27.76	25.78	25.68	-0.0395367336603046	6.23152439929298	0.547210559915537	0.848924903713125	X:47232689-47248328:+	USP11	15;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 11 [Source:HGNC Symbol%3BAcc:HGNC:12609]
ENSG00000178184	1.03	1.07	1.01	0.77	1.04	0.85	0.234239318515954	0.341362611257236	0.547212950455177	0.848924903713125	18:80157231-80247546:-	PARD6G	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007049,biological_process cell cycle;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0043234,cellular_component protein complex;GO:0051301,biological_process cell division;GO:0070830,biological_process bicellular tight junction assembly	PARD6; partitioning defective protein 6; K06093	par-6 family cell polarity regulator gamma [Source:HGNC Symbol%3BAcc:HGNC:16076]
ENSG00000083828	2.61	2.01	1.78	2.62	1.98	2.51	-0.133902211717941	1.89088578377035	0.547330926223129	0.848924903713125	19:57769654-57819939:+	ZNF586	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 586 [Source:HGNC Symbol%3BAcc:HGNC:25949]
ENSG00000100207	13.74	12.92	13.82	13.37	13.50	12.88	0.0400894858538894	6.30488929058235	0.547405449108106	0.848924903713125	22:42160012-42343616:-	TCF20	12;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016604,cellular_component nuclear body;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	transcription factor 20 [Source:HGNC Symbol%3BAcc:HGNC:11631]
ENSG00000097096	1.52	1.89	1.62	1.76	1.78	1.86	-0.103695024988373	2.66983909703521	0.54741852446321	0.848924903713125	1:85156872-85201046:-	SYDE2	7;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0090630,biological_process activation of GTPase activity	NA	synapse defective Rho GTPase homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:25841]
ENSG00000196812	6.09	5.13	6.77	6.38	6.97	6.13	-0.0894720548508095	2.74561964012883	0.547465022069764	0.848924903713125	6:28124559-28130082:+	ZSCAN16	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 16 [Source:HGNC Symbol%3BAcc:HGNC:20813]
ENSG00000118690	1.42	1.27	1.20	1.34	1.53	1.42	-0.119579095629565	1.90625397197192	0.547551932263276	0.848924903713125	6:108848415-108974472:+	ARMC2	1;GO:0005515,molecular_function protein binding	NA	armadillo repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:23045]
ENSG00000151014	6.41	5.23	5.85	6.90	5.97	5.90	-0.079887649600002	3.04443435585646	0.547598622736727	0.848924903713125	4:139015788-139045939:+	NOCT	31;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0007623,biological_process circadian rhythm;GO:0009991,biological_process response to extracellular stimulus;GO:0010629,biological_process negative regulation of gene expression;GO:0016787,molecular_function hydrolase activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0032922,biological_process circadian regulation of gene expression;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0042752,biological_process regulation of circadian rhythm;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045995,biological_process regulation of embryonic development;GO:0046872,molecular_function metal ion binding;GO:0048255,biological_process mRNA stabilization;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048511,biological_process rhythmic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	nocturnin [Source:HGNC Symbol%3BAcc:HGNC:14254]
ENSG00000135503	14.40	15.86	14.18	13.98	14.93	14.26	0.0479258990339004	4.78026355924384	0.547771267850436	0.849086506971461	12:51951666-51997078:+	ACVR1B	51;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0001701,biological_process in utero embryonic development;GO:0001942,biological_process hair follicle development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007417,biological_process central nervous system development;GO:0009966,biological_process regulation of signal transduction;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016361,molecular_function activin receptor activity, type I;GO:0016740,molecular_function transferase activity;GO:0017002,molecular_function activin-activated receptor activity;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019838,molecular_function growth factor binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030308,biological_process negative regulation of cell growth;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032924,biological_process activin receptor signaling pathway;GO:0032927,biological_process positive regulation of activin receptor signaling pathway;GO:0034711,molecular_function inhibin binding;GO:0038092,biological_process nodal signaling pathway;GO:0043235,cellular_component receptor complex;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046545,biological_process development of primary female sexual characteristics;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048179,cellular_component activin receptor complex;GO:0048185,molecular_function activin binding;GO:0070062,cellular_component extracellular exosome;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1901165,biological_process positive regulation of trophoblast cell migration	ACVR1B, ALK4; activin receptor type-1B [EC:2.7.11.30]; K13567	activin A receptor type 1B [Source:HGNC Symbol%3BAcc:HGNC:172]
ENSG00000179104	3.24	3.40	3.38	3.06	3.28	3.23	0.0752617295936079	3.11784623499218	0.547900970264588	0.849157006774064	12:82686879-83134870:+	TMTC2	6;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055074,biological_process calcium ion homeostasis	NA	transmembrane and tetratricopeptide repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25440]
ENSG00000079101	1.03	1.10	0.80	1.73	1.01	0.68	-0.212207494131854	0.917062844382651	0.548038333965718	0.849157006774064	18:596987-650334:+	CLUL1	1;GO:0005576,cellular_component extracellular region	NA	clusterin like 1 [Source:HGNC Symbol%3BAcc:HGNC:2096]
ENSG00000151611	7.16	7.36	9.19	6.94	7.27	8.34	0.0858023873826744	3.32027725934773	0.548102056631295	0.849157006774064	4:145618262-145660035:+	MMAA	9;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0009235,biological_process cobalamin metabolic process;GO:0009236,biological_process cobalamin biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0019626,biological_process short-chain fatty acid catabolic process	NA	methylmalonic aciduria (cobalamin deficiency) cblA type [Source:HGNC Symbol%3BAcc:HGNC:18871]
ENSG00000170903	21.09	22.81	22.12	21.85	23.23	23.78	-0.0533397726823636	4.54953109273628	0.548171551177858	0.849157006774064	11:105995622-106022403:-	MSANTD4	1;GO:0005634,cellular_component nucleus	NA	Myb/SANT DNA binding domain containing 4 with coiled-coils [Source:HGNC Symbol%3BAcc:HGNC:29383]
ENSG00000005238	12.08	13.80	12.95	12.57	12.73	12.29	0.0524255681737818	4.36965946817972	0.548209733308952	0.849157006774064	9:35104111-35116341:-	FAM214B	2;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	family with sequence similarity 214 member B [Source:HGNC Symbol%3BAcc:HGNC:25666]
ENSG00000160050	8.62	6.89	8.04	7.75	5.73	8.59	0.112074514695461	2.75057570816064	0.548227201505466	0.849157006774064	1:32200385-32205387:+	CCDC28B	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0060271,biological_process cilium morphogenesis	NA	coiled-coil domain containing 28B [Source:HGNC Symbol%3BAcc:HGNC:28163]
ENSG00000125779	21.44	16.99	19.63	19.92	19.03	22.00	-0.0527590689464818	5.09556992983562	0.548305285563268	0.849171991228552	20:3888838-3929882:+	PANK2	20;GO:0000166,molecular_function nucleotide binding;GO:0004594,molecular_function pantothenate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0007286,biological_process spermatid development;GO:0009060,biological_process aerobic respiration;GO:0009108,biological_process coenzyme biosynthetic process;GO:0015937,biological_process coenzyme A biosynthetic process;GO:0015939,biological_process pantothenate metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019217,biological_process regulation of fatty acid metabolic process;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0070584,biological_process mitochondrion morphogenesis;GO:0090207,biological_process regulation of triglyceride metabolic process;GO:1904251,biological_process regulation of bile acid metabolic process	coaW; type II pantothenate kinase [EC:2.7.1.33]; K09680	pantothenate kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:15894]
ENSG00000103111	15.74	15.19	14.96	13.81	15.69	15.17	0.0515463770117195	4.6838775408872	0.54846815484753	0.849318264236825	16:77190834-77202405:+	MON1B	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0012505,cellular_component endomembrane system;GO:0016192,biological_process vesicle-mediated transport;GO:0019085,biological_process early viral transcription;GO:0019086,biological_process late viral transcription	NA	MON1 homolog B%2C secretory trafficking associated [Source:HGNC Symbol%3BAcc:HGNC:25020]
ENSG00000068079	37.03	41.81	39.78	40.04	40.55	42.73	-0.0494321858632776	5.12859152654004	0.548654292475733	0.849500527940786	17:43006724-43014456:+	IFI35	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0060337,biological_process type I interferon signaling pathway	NA	interferon induced protein 35 [Source:HGNC Symbol%3BAcc:HGNC:5399]
ENSG00000100395	10.48	10.75	10.76	11.02	10.50	9.58	0.053112814725833	4.61169022744926	0.549058033920713	0.84995302115841	22:41205204-41231271:+	L3MBTL2	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0016925,biological_process protein sumoylation;GO:0035064,molecular_function methylated histone binding;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding	HK; hexokinase [EC:2.7.1.1]; K00844	L3MBTL2%2C polycomb repressive complex 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:18594]
ENSG00000143110	1.22	2.47	2.85	2.42	0.82	2.27	0.23145265072363	0.107016074979342	0.549083483176451	0.84995302115841	1:111473791-111478512:+	C1orf162	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 1 open reading frame 162 [Source:HGNC Symbol%3BAcc:HGNC:28344]
ENSG00000187079	15.87	18.32	14.75	16.45	18.03	16.72	-0.0606130819199333	4.75047434573946	0.549454021623755	0.850404677089346	11:12674590-12944483:+	TEAD1	25;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001134,molecular_function transcription factor activity, transcription factor recruiting;GO:0001159,molecular_function core promoter proximal region DNA binding;GO:0001223,molecular_function transcription coactivator binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0035329,biological_process hippo signaling;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048568,biological_process embryonic organ development;GO:0071148,cellular_component TEAD-1-YAP complex;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter	TEAD; transcriptional enhancer factor; K09448	TEA domain transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11714]
ENSG00000102547	4.73	4.61	3.69	4.20	4.85	5.12	-0.115636394847618	2.25162290061103	0.549519477816609	0.850404677089346	13:49308649-49444126:-	CAB39L	4;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007050,biological_process cell cycle arrest;GO:0070062,cellular_component extracellular exosome	CAB39, MO25; calcium binding protein 39; K08272	calcium binding protein 39 like [Source:HGNC Symbol%3BAcc:HGNC:20290]
ENSG00000163626	11.44	8.55	10.02	12.43	11.23	8.74	-0.0870587459361729	3.4148317058533	0.549580787852311	0.850404677089346	4:73052361-73069755:-	COX18	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0051204,biological_process protein insertion into mitochondrial membrane;GO:0051205,biological_process protein insertion into membrane	NA	COX18%2C cytochrome c oxidase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:26801]
ENSG00000124782	6.41	6.95	6.31	7.08	6.94	6.45	-0.0489123675927902	5.13262106118341	0.549672361119125	0.850440361282774	6:7107596-7251980:+	RREB1	27;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007265,biological_process Ras protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1903691,biological_process positive regulation of wound healing, spreading of epidermal cells;GO:2000394,biological_process positive regulation of lamellipodium morphogenesis	NA	ras responsive element binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10449]
ENSG00000150316	89.34	91.95	94.06	96.89	92.62	95.60	-0.0389951785943412	6.00828763802972	0.549832142245957	0.850581553053224	11:94962621-94973612:-	CWC15	11;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005739,cellular_component mitochondrion;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	CWC15 spliceosome associated protein homolog [Source:HGNC Symbol%3BAcc:HGNC:26939]
ENSG00000124226	39.01	39.69	41.06	42.19	39.19	43.15	-0.0451339338938204	5.19971913473771	0.549947027025043	0.850653264356618	20:49936335-49953892:+	RNF114	16;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 114 [Source:HGNC Symbol%3BAcc:HGNC:13094]
ENSG00000151790	3.25	2.28	2.84	2.77	2.18	2.77	0.143980014232401	1.78340900093653	0.550304446003403	0.851100060832325	4:155854737-155920406:+	TDO2	16;GO:0004833,molecular_function tryptophan 2,3-dioxygenase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006568,biological_process tryptophan metabolic process;GO:0006569,biological_process tryptophan catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016597,molecular_function amino acid binding;GO:0019441,biological_process tryptophan catabolic process to kynurenine;GO:0019442,biological_process tryptophan catabolic process to acetyl-CoA;GO:0019825,molecular_function oxygen binding;GO:0020037,molecular_function heme binding;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process	TDO2, kynA; tryptophan 2,3-dioxygenase [EC:1.13.11.11]; K00453	tryptophan 2%2C3-dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:11708]
ENSG00000138182	8.34	9.80	8.90	9.05	11.21	8.20	-0.0639995588230398	5.66132645466904	0.550401988168578	0.851120774979956	10:89701609-89774939:+	KIF20B	48;GO:0000166,molecular_function nucleotide binding;GO:0000922,cellular_component spindle pole;GO:0001843,biological_process neural tube closure;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008017,molecular_function microtubule binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016887,molecular_function ATPase activity;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035372,biological_process protein localization to microtubule;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048812,biological_process neuron projection morphogenesis;GO:0050699,molecular_function WW domain binding;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0070201,biological_process regulation of establishment of protein localization;GO:0070938,cellular_component contractile ring;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0097431,cellular_component mitotic spindle pole;GO:1903438,biological_process positive regulation of mitotic cytokinetic process;GO:1990023,cellular_component mitotic spindle midzone;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2001222,biological_process regulation of neuron migration;GO:2001224,biological_process positive regulation of neuron migration	NA	kinesin family member 20B [Source:HGNC Symbol%3BAcc:HGNC:7212]
ENSG00000156535	65.41	65.85	67.83	65.96	62.90	66.99	0.0354882518822719	8.15832150541429	0.550454973136155	0.851120774979956	6:73695784-73828316:+	CD109	22;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001942,biological_process hair follicle development;GO:0002576,biological_process platelet degranulation;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0009986,cellular_component cell surface;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0030414,molecular_function peptidase inhibitor activity;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031092,cellular_component platelet alpha granule membrane;GO:0031225,cellular_component anchored component of membrane;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0050431,molecular_function transforming growth factor beta binding;GO:0061045,biological_process negative regulation of wound healing;GO:0072675,biological_process osteoclast fusion	NA	CD109 molecule [Source:HGNC Symbol%3BAcc:HGNC:21685]
ENSG00000102043	0.90	0.90	0.73	0.89	1.15	0.83	-0.164543470746609	1.03731566599444	0.55072858822083	0.851300718740184	X:64268080-64395431:-	MTMR8	12;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0010506,biological_process regulation of autophagy;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	NA	myotubularin related protein 8 [Source:HGNC Symbol%3BAcc:HGNC:16825]
ENSG00000014164	14.40	13.95	15.28	13.97	15.67	15.80	-0.0447679391861239	5.47732664744288	0.550746038681153	0.851300718740184	8:143437654-143541453:-	ZC3H3	17;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004521,molecular_function endoribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006378,biological_process mRNA polyadenylation;GO:0006810,biological_process transport;GO:0010793,biological_process regulation of mRNA export from nucleus;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0031124,biological_process mRNA 3'-end processing;GO:0032927,biological_process positive regulation of activin receptor signaling pathway;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0051028,biological_process mRNA transport;GO:0070412,molecular_function R-SMAD binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	zinc finger CCCH-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28972]
ENSG00000103671	13.76	12.74	12.77	15.03	13.00	13.12	-0.0531083851214625	4.63365133867081	0.550777094352889	0.851300718740184	15:64387747-64455303:+	TRIP4	27;GO:0002020,molecular_function protease binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016604,cellular_component nuclear body;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019901,molecular_function protein kinase binding;GO:0030331,molecular_function estrogen receptor binding;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0031594,cellular_component neuromuscular junction;GO:0035035,molecular_function histone acetyltransferase binding;GO:0043234,cellular_component protein complex;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0045661,biological_process regulation of myoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0099053,cellular_component activating signal cointegrator 1 complex;GO:1901998,biological_process toxin transport	NA	thyroid hormone receptor interactor 4 [Source:HGNC Symbol%3BAcc:HGNC:12310]
ENSG00000185112	1.06	0.98	1.86	1.59	0.78	2.22	-0.216757241647769	0.981092810249397	0.55093516305665	0.851363551459523	3:194686543-194689037:+	FAM43A	NA	NA	family with sequence similarity 43 member A [Source:HGNC Symbol%3BAcc:HGNC:26888]
ENSG00000163875	62.11	54.67	57.80	63.75	59.34	58.84	-0.0433688289638279	5.34448835947394	0.550954918945811	0.851363551459523	1:37492574-37514774:-	MEAF6	23;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016604,cellular_component nuclear body;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0043968,biological_process histone H2A acetylation;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043983,biological_process histone H4-K12 acetylation;GO:0044154,biological_process histone H3-K14 acetylation;GO:0070776,cellular_component MOZ/MORF histone acetyltransferase complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	MYST/Esa1 associated factor 6 [Source:HGNC Symbol%3BAcc:HGNC:25674]
ENSG00000168612	10.34	9.39	8.55	9.93	8.70	8.51	0.0730562119942192	3.76501844515335	0.551056430911039	0.85137010671952	20:45881226-45885266:+	ZSWIM1	3;GO:0005634,cellular_component nucleus;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger SWIM-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16155]
ENSG00000176422	6.37	7.39	4.74	6.27	7.82	6.11	-0.128986119978794	2.04729000377571	0.551133385293665	0.85137010671952	12:56468566-56479707:+	SPRYD4	4;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process	NA	SPRY domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:27468]
ENSG00000101310	26.55	26.50	25.59	27.20	24.72	25.15	0.0402622021152899	5.90421443382485	0.55116492206542	0.85137010671952	20:18507492-18561415:+	SEC23B	16;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008270,molecular_function zinc ion binding;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030127,cellular_component COPII vesicle coat;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	SEC23; protein transport protein SEC23; K14006	Sec23 homolog B%2C coat complex II component [Source:HGNC Symbol%3BAcc:HGNC:10702]
ENSG00000104953	1.36	1.39	1.20	1.57	1.19	1.64	-0.152932175707466	1.34804276675624	0.551339960502281	0.8514946963909	19:2977445-2995184:+	TLE6	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005938,cellular_component cell cortex;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043234,cellular_component protein complex;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0050769,biological_process positive regulation of neurogenesis;GO:0060136,biological_process embryonic process involved in female pregnancy	NA	transducin like enhancer of split 6 [Source:HGNC Symbol%3BAcc:HGNC:30788]
ENSG00000168140	18.78	21.77	20.16	18.76	22.88	21.77	-0.0546476357665809	5.3887783932661	0.551382773671961	0.8514946963909	16:4371847-4383528:+	VASN	16;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0009986,cellular_component cell surface;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0045296,molecular_function cadherin binding;GO:0050431,molecular_function transforming growth factor beta binding;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia;GO:0071461,biological_process cellular response to redox state	NA	vasorin [Source:HGNC Symbol%3BAcc:HGNC:18517]
ENSG00000164403	2.74	4.00	3.34	3.66	4.09	3.08	-0.104490282342629	3.17041881167481	0.551498184535995	0.851566981545629	5:132822140-132830898:-	SHROOM1	8;GO:0000902,biological_process cell morphogenesis;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0016460,cellular_component myosin II complex;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly	NA	shroom family member 1 [Source:HGNC Symbol%3BAcc:HGNC:24084]
ENSG00000158079	5.89	5.00	7.02	5.98	6.57	6.51	-0.068238168104741	3.96982155802699	0.551718976664632	0.85180194743011	9:94030793-94109856:+	PTPDC1	14;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0007224,biological_process smoothened signaling pathway;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030030,biological_process cell projection organization;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0060271,biological_process cilium morphogenesis	NA	protein tyrosine phosphatase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30184]
ENSG00000051523	247.05	241.11	242.40	237.47	245.54	235.94	0.0350697407971138	7.92116652732179	0.551856971790253	0.851835760359859	16:88643282-88651152:-	CYBA	73;GO:0001666,biological_process response to hypoxia;GO:0001725,cellular_component stress fiber;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003106,biological_process negative regulation of glomerular filtration by angiotensin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006801,biological_process superoxide metabolic process;GO:0006954,biological_process inflammatory response;GO:0008217,biological_process regulation of blood pressure;GO:0009055,molecular_function electron carrier activity;GO:0014823,biological_process response to activity;GO:0014895,biological_process smooth muscle hypertrophy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016175,molecular_function superoxide-generating NADPH oxidase activity;GO:0016324,cellular_component apical plasma membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0017004,biological_process cytochrome complex assembly;GO:0017124,molecular_function SH3 domain binding;GO:0020037,molecular_function heme binding;GO:0030141,cellular_component secretory granule;GO:0030307,biological_process positive regulation of cell growth;GO:0030425,cellular_component dendrite;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031667,biological_process response to nutrient levels;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0033864,biological_process positive regulation of NAD(P)H oxidase activity;GO:0034137,biological_process positive regulation of toll-like receptor 2 signaling pathway;GO:0034599,biological_process cellular response to oxidative stress;GO:0035579,cellular_component specific granule membrane;GO:0042493,biological_process response to drug;GO:0042554,biological_process superoxide anion generation;GO:0043020,cellular_component NADPH oxidase complex;GO:0043025,cellular_component neuronal cell body;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0045454,biological_process cell redox homeostasis;GO:0045730,biological_process respiratory burst;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050665,biological_process hydrogen peroxide biosynthetic process;GO:0050766,biological_process positive regulation of phagocytosis;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0055114,biological_process oxidation-reduction process;GO:0070257,biological_process positive regulation of mucus secretion;GO:0070555,biological_process response to interleukin-1;GO:0070821,cellular_component tertiary granule membrane;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071310,biological_process cellular response to organic substance;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071480,biological_process cellular response to gamma radiation;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0097038,cellular_component perinuclear endoplasmic reticulum;GO:1900426,biological_process positive regulation of defense response to bacterium;GO:1903428,biological_process positive regulation of reactive oxygen species biosynthetic process;GO:1904044,biological_process response to aldosterone;GO:1904385,biological_process cellular response to angiotensin;GO:1904845,biological_process cellular response to L-glutamine	CYBA, P22PHOX; cytochrome b-245, alpha polypeptide; K08009	cytochrome b-245 alpha chain [Source:HGNC Symbol%3BAcc:HGNC:2577]
ENSG00000138311	1.35	1.55	2.08	1.50	1.81	1.24	0.145114094521595	1.79588998019057	0.551878126545878	0.851835760359859	10:62374191-62672011:+	ZNF365	10;GO:0000281,biological_process mitotic cytokinesis;GO:0000930,cellular_component gamma-tubulin complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0033566,biological_process gamma-tubulin complex localization;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	zinc finger protein 365 [Source:HGNC Symbol%3BAcc:HGNC:18194]
ENSG00000216588	1.29	2.56	1.70	1.73	1.57	1.46	0.193047378262036	0.617638797773494	0.552211347621523	0.852152348451932	19:44613629-44636781:+	IGSF23	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	immunoglobulin superfamily member 23 [Source:HGNC Symbol%3BAcc:HGNC:40040]
ENSG00000165406	5.55	6.06	5.78	7.27	5.16	6.18	-0.0907480978328584	3.38757841819743	0.552220534193776	0.852152348451932	10:45454584-45594906:-	MARCH8	16;GO:0000209,biological_process protein polyubiquitination;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0046872,molecular_function metal ion binding	NA	membrane associated ring-CH-type finger 8 [Source:HGNC Symbol%3BAcc:HGNC:23356]
ENSG00000115421	5.82	6.97	6.90	5.09	6.49	7.17	0.0769335436472227	3.83550257415463	0.552340190727633	0.852231048788328	2:60756229-60802085:+	PAPOLG	16;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004652,molecular_function polynucleotide adenylyltransferase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0031123,biological_process RNA 3'-end processing;GO:0043631,biological_process RNA polyadenylation;GO:0046872,molecular_function metal ion binding	PAP; poly(A) polymerase [EC:2.7.7.19]; K14376	poly(A) polymerase gamma [Source:HGNC Symbol%3BAcc:HGNC:14982]
ENSG00000126254	50.47	44.86	45.85	51.06	48.61	46.98	-0.0406101263700227	6.11519560832307	0.55249636456045	0.85236606677714	19:35629029-35637686:+	RBM42	6;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome	NA	RNA binding motif protein 42 [Source:HGNC Symbol%3BAcc:HGNC:28117]
ENSG00000104267	78.92	97.25	81.21	82.00	99.64	87.59	-0.0560962880049292	6.2244806573936	0.552769008458035	0.852649430612352	8:85463851-85481493:+	CA2	39;GO:0001822,biological_process kidney development;GO:0002009,biological_process morphogenesis of an epithelium;GO:0004064,molecular_function arylesterase activity;GO:0004089,molecular_function carbonate dehydratase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006730,biological_process one-carbon metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009268,biological_process response to pH;GO:0010033,biological_process response to organic substance;GO:0010043,biological_process response to zinc ion;GO:0015670,biological_process carbon dioxide transport;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016829,molecular_function lyase activity;GO:0030424,cellular_component axon;GO:0032230,biological_process positive regulation of synaptic transmission, GABAergic;GO:0032849,biological_process positive regulation of cellular pH reduction;GO:0038166,biological_process angiotensin-activated signaling pathway;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043209,cellular_component myelin sheath;GO:0043627,biological_process response to estrogen;GO:0044070,biological_process regulation of anion transport;GO:0045177,cellular_component apical part of cell;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045780,biological_process positive regulation of bone resorption;GO:0046872,molecular_function metal ion binding;GO:0046903,biological_process secretion;GO:0048545,biological_process response to steroid hormone;GO:0051453,biological_process regulation of intracellular pH;GO:0070062,cellular_component extracellular exosome;GO:0071498,biological_process cellular response to fluid shear stress;GO:2001150,biological_process positive regulation of dipeptide transmembrane transport;GO:2001225,biological_process regulation of chloride transport	CA; carbonic anhydrase [EC:4.2.1.1]; K01672	carbonic anhydrase 2 [Source:HGNC Symbol%3BAcc:HGNC:1373]
ENSG00000196776	104.00	91.91	95.61	103.21	91.83	108.37	-0.0447617412007733	6.66428284385872	0.552817418639185	0.852649430612352	3:108043297-108091025:-	CD47	21;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008228,biological_process opsonization;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009617,biological_process response to bacterium;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050870,biological_process positive regulation of T cell activation;GO:0050900,biological_process leukocyte migration;GO:0070053,molecular_function thrombospondin receptor activity;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane	CD47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); K06266	CD47 molecule [Source:HGNC Symbol%3BAcc:HGNC:1682]
ENSG00000278311	52.83	53.68	56.31	53.84	52.39	53.74	0.0373635410990993	6.94506824154218	0.552890804023611	0.852656671679102	17:36544887-36589848:+	GGNBP2	13;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033140,biological_process negative regulation of peptidyl-serine phosphorylation of STAT protein;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0060711,biological_process labyrinthine layer development;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity	NA	gametogenetin binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:19357]
ENSG00000018510	47.14	43.50	45.35	46.17	45.56	49.25	-0.0390321653460266	6.53698898175105	0.553073844653988	0.852689491955356	2:177392643-177559299:+	AGPS	18;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0006629,biological_process lipid metabolic process;GO:0008609,molecular_function alkylglycerone-phosphate synthase activity;GO:0008610,biological_process lipid biosynthetic process;GO:0008611,biological_process ether lipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016614,molecular_function oxidoreductase activity, acting on CH-OH group of donors;GO:0016740,molecular_function transferase activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	AGPS, agpS; alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]; K00803	alkylglycerone phosphate synthase [Source:HGNC Symbol%3BAcc:HGNC:327]
ENSG00000178665	2.99	2.60	2.37	2.20	2.61	2.57	0.124256054399381	1.89674922277414	0.553111527059481	0.852689491955356	7:55887474-55942225:+	ZNF713	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 713 [Source:HGNC Symbol%3BAcc:HGNC:22043]
ENSG00000188986	40.86	42.00	39.34	41.41	43.44	41.62	-0.0389272572566309	6.29018804369938	0.553118165570332	0.852689491955356	9:137255172-137273546:+	NELFB	13;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0032021,cellular_component NELF complex;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0050434,biological_process positive regulation of viral transcription	NA	negative elongation factor complex member B [Source:HGNC Symbol%3BAcc:HGNC:24324]
ENSG00000165474	32.50	18.61	31.37	29.26	18.68	29.04	0.117394356904986	4.19747573117263	0.553275703683615	0.85276686011859	13:20187469-20192898:-	GJB2	35;GO:0002931,biological_process response to ischemia;GO:0005243,molecular_function gap junction channel activity;GO:0005737,cellular_component cytoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005921,cellular_component gap junction;GO:0005922,cellular_component connexon complex;GO:0006810,biological_process transport;GO:0007154,biological_process cell communication;GO:0007267,biological_process cell-cell signaling;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0007605,biological_process sensory perception of sound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016264,biological_process gap junction assembly;GO:0016328,cellular_component lateral plasma membrane;GO:0030054,cellular_component cell junction;GO:0032355,biological_process response to estradiol;GO:0032496,biological_process response to lipopolysaccharide;GO:0032526,biological_process response to retinoic acid;GO:0032570,biological_process response to progesterone;GO:0034599,biological_process cellular response to oxidative stress;GO:0044297,cellular_component cell body;GO:0044752,biological_process response to human chorionic gonadotropin;GO:0046677,biological_process response to antibiotic;GO:0046697,biological_process decidualization;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048839,biological_process inner ear development;GO:0055085,biological_process transmembrane transport;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0097449,cellular_component astrocyte projection;GO:1905867,biological_process epididymis development	GJB2, CX26; gap junction beta-2 protein; K07621	gap junction protein beta 2 [Source:HGNC Symbol%3BAcc:HGNC:4284]
ENSG00000147324	4.30	3.75	2.96	3.51	3.80	4.50	-0.0903399454388204	3.6070132554588	0.553305751340943	0.85276686011859	8:8783353-8893645:-	MFHAS1	5;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction	NA	malignant fibrous histiocytoma amplified sequence 1 [Source:HGNC Symbol%3BAcc:HGNC:16982]
ENSG00000147274	112.27	128.44	114.41	118.06	130.33	120.33	-0.0439347314882137	7.23806074893522	0.553434918668917	0.852857444187489	X:136848003-136880764:-	RBMX	36;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001047,molecular_function core promoter binding;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005719,cellular_component nuclear euchromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0019904,molecular_function protein domain specific binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042802,molecular_function identical protein binding;GO:0044530,cellular_component supraspliceosomal complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0051259,biological_process protein oligomerization;GO:0051260,biological_process protein homooligomerization;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071347,biological_process cellular response to interleukin-1	RBMX, HNRNPG; heterogeneous nuclear ribonucleoprotein G; K12885	RNA binding motif protein%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:9910]
ENSG00000078043	21.67	20.95	23.22	24.26	21.31	22.96	-0.044062652232189	5.55478879892835	0.553501939126272	0.852857444187489	18:46803223-46920160:-	PIAS2	25;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0061665,molecular_function SUMO ligase activity	PIAS2; E3 SUMO-protein ligase PIAS2 [EC:2.3.2.-]; K16063	protein inhibitor of activated STAT 2 [Source:HGNC Symbol%3BAcc:HGNC:17311]
ENSG00000047230	10.47	10.34	10.64	10.43	12.57	10.09	-0.0590530134187787	4.36106586115164	0.553577777423516	0.852868431321597	X:16588002-16712936:-	CTPS2	12;GO:0000166,molecular_function nucleotide binding;GO:0003883,molecular_function CTP synthase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006220,biological_process pyrimidine nucleotide metabolic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016874,molecular_function ligase activity;GO:0044210,biological_process 'de novo' CTP biosynthetic process	pyrG, CTPS; CTP synthase [EC:6.3.4.2]; K01937	CTP synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:2520]
ENSG00000122674	30.38	28.48	28.05	28.74	26.07	30.10	0.0456962047949173	5.37864329793202	0.553806042312349	0.853048798054975	7:5898724-5926550:+	CCZ1	12;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016235,cellular_component aggresome;GO:0031982,cellular_component vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	CCZ1 homolog%2C vacuolar protein trafficking and biogenesis associated [Source:HGNC Symbol%3BAcc:HGNC:21691]
ENSG00000104998	3.96	4.01	4.47	3.49	4.01	4.31	0.0860849186118583	2.9776883409594	0.55383229384718	0.853048798054975	19:14031747-14053216:+	IL27RA	15;GO:0002827,biological_process positive regulation of T-helper 1 type immune response;GO:0002829,biological_process negative regulation of type 2 immune response;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0045509,molecular_function interleukin-27 receptor activity;GO:0048302,biological_process regulation of isotype switching to IgG isotypes;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0070106,biological_process interleukin-27-mediated signaling pathway	NA	interleukin 27 receptor subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:17290]
ENSG00000142937	1698.87	1596.43	1658.62	1697.10	1551.00	1622.84	0.0361623837846473	9.9981522907041	0.554083623934812	0.853217745758049	1:44775250-44778779:+	RPS8	22;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein S8 [Source:HGNC Symbol%3BAcc:HGNC:10441]
ENSG00000130821	80.38	83.93	83.14	82.57	80.63	80.10	0.0357578417646834	7.36532296369395	0.554155981752088	0.853217745758049	X:153688098-153696593:+	SLC6A8	20;GO:0003674,molecular_function molecular_function;GO:0005308,molecular_function creatine transmembrane transporter activity;GO:0005309,molecular_function creatine:sodium symporter activity;GO:0005328,molecular_function neurotransmitter:sodium symporter activity;GO:0005575,cellular_component cellular_component;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006600,biological_process creatine metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006836,biological_process neurotransmitter transport;GO:0006936,biological_process muscle contraction;GO:0008150,biological_process biological_process;GO:0015293,molecular_function symporter activity;GO:0015881,biological_process creatine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:1902598,biological_process creatine transmembrane transport	NA	solute carrier family 6 member 8 [Source:HGNC Symbol%3BAcc:HGNC:11055]
ENSG00000147677	277.72	272.44	276.11	288.89	275.24	288.85	-0.0340443520844827	8.66420610168366	0.554193095209992	0.853217745758049	8:116642129-116766925:-	EIF3H	15;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016020,cellular_component membrane;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0070062,cellular_component extracellular exosome;GO:0071541,cellular_component eukaryotic translation initiation factor 3 complex, eIF3m	EIF3H; translation initiation factor 3 subunit H; K03247	eukaryotic translation initiation factor 3 subunit H [Source:HGNC Symbol%3BAcc:HGNC:3273]
ENSG00000137411	10.27	8.95	10.62	10.62	10.32	10.25	-0.0452406441219122	5.06997575602175	0.554261309541922	0.853217745758049	6:30908241-30926459:+	VARS2	11;GO:0000166,molecular_function nucleotide binding;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004832,molecular_function valine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006438,biological_process valyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0016874,molecular_function ligase activity	VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]; K01873	valyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:21642]
ENSG00000256294	3.93	3.68	4.57	3.75	4.05	3.85	0.0851135172732649	3.12699822141592	0.554345353909455	0.853217745758049	19:44112180-44134816:+	ZNF225	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 225 [Source:HGNC Symbol%3BAcc:HGNC:13018]
ENSG00000164776	1.34	1.43	1.80	1.77	1.08	1.22	0.182860131421639	0.982814698751754	0.554354396160369	0.853217745758049	7:56080282-56092996:-	PHKG1	21;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004689,molecular_function phosphorylase kinase activity;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005964,cellular_component phosphorylase kinase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0005980,biological_process glycogen catabolic process;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0035556,biological_process intracellular signal transduction;GO:0050321,molecular_function tau-protein kinase activity	PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]; K00871	phosphorylase kinase catalytic subunit gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:8930]
ENSG00000158411	44.87	37.31	43.96	45.18	39.17	48.03	-0.0533484585143202	5.14868285134675	0.55488317802906	0.85383301615823	2:99161426-99181058:-	MITD1	17;GO:0000281,biological_process mitotic cytokinesis;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0019898,cellular_component extrinsic component of membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030496,cellular_component midbody;GO:0031902,cellular_component late endosome membrane;GO:0032091,biological_process negative regulation of protein binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome	NA	microtubule interacting and trafficking domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25207]
ENSG00000170881	44.28	45.38	44.34	42.32	46.18	43.00	0.0385186357560498	6.46482563334871	0.554900446430552	0.85383301615823	8:124474737-124487914:+	RNF139	30;GO:0000209,biological_process protein polyubiquitination;GO:0002020,molecular_function protease binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0017148,biological_process negative regulation of translation;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031648,biological_process protein destabilization;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:0060628,biological_process regulation of ER to Golgi vesicle-mediated transport;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070613,biological_process regulation of protein processing;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904380,biological_process endoplasmic reticulum mannose trimming;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	ring finger protein 139 [Source:HGNC Symbol%3BAcc:HGNC:17023]
ENSG00000178982	162.75	178.11	166.83	171.66	168.28	157.55	0.0396903537445192	6.85500372014579	0.554960507078434	0.85383301615823	19:38619081-38636955:+	EIF3K	16;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016020,cellular_component membrane;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0033290,cellular_component eukaryotic 48S preinitiation complex;GO:0043022,molecular_function ribosome binding;GO:0070062,cellular_component extracellular exosome	NA	eukaryotic translation initiation factor 3 subunit K [Source:HGNC Symbol%3BAcc:HGNC:24656]
ENSG00000158850	28.63	29.34	28.72	28.51	29.20	27.02	0.0441451799334856	5.08039940769444	0.55510850755146	0.853851213217321	1:161171309-161177968:-	B4GALT3	17;GO:0000139,cellular_component Golgi membrane;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945,molecular_function N-acetyllactosamine synthase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006682,biological_process galactosylceramide biosynthetic process;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	B4GALT3; beta-1,4-galactosyltransferase 3 [EC:2.4.1.90 2.4.1.38 2.4.1.-]; K07968	beta-1%2C4-galactosyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:926]
ENSG00000187239	19.70	19.49	21.24	21.36	21.36	20.14	-0.0427629078431883	5.26971829455395	0.555109908214274	0.853851213217321	9:129887186-130043194:-	FNBP1	14;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005938,cellular_component cell cortex;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042802,molecular_function identical protein binding;GO:0061024,biological_process membrane organization	NA	formin binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17069]
ENSG00000182108	24.29	29.84	24.53	24.17	29.80	30.10	-0.0976370753862742	2.97456731230595	0.555387624823634	0.854172542056223	16:10928890-10942460:-	DEXI	NA	NA	Dexi homolog [Source:HGNC Symbol%3BAcc:HGNC:13267]
ENSG00000214063	103.42	113.66	110.74	114.59	112.14	112.64	-0.0400085209076757	6.42470388629962	0.55549114856931	0.854225920117796	11:842807-867116:+	TSPAN4	11;GO:0003823,molecular_function antigen binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006461,biological_process protein complex assembly;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031982,cellular_component vesicle	NA	tetraspanin 4 [Source:HGNC Symbol%3BAcc:HGNC:11859]
ENSG00000011007	21.54	22.79	20.41	22.83	22.11	22.15	-0.0427497360938857	5.72111810766947	0.555661336763813	0.854336064688858	1:23743154-23762059:+	ELOA	13;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006414,biological_process translational elongation;GO:0016021,cellular_component integral component of membrane;GO:0070449,cellular_component elongin complex	NA	elongin A [Source:HGNC Symbol%3BAcc:HGNC:11620]
ENSG00000136536	45.69	45.15	48.19	48.30	45.52	50.27	-0.0393517856106333	6.67558345991694	0.555700425867867	0.854336064688858	2:159712456-159771027:+	MARCH7	6;GO:0002643,biological_process regulation of tolerance induction;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0046872,molecular_function metal ion binding	NA	membrane associated ring-CH-type finger 7 [Source:HGNC Symbol%3BAcc:HGNC:17393]
ENSG00000174640	7.91	5.00	8.93	8.03	6.64	9.04	-0.0975345377521314	3.90262172949376	0.555893493668094	0.854527051009542	3:133932695-134052184:-	SLCO2A1	13;GO:0005215,molecular_function transporter activity;GO:0005319,molecular_function lipid transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006869,biological_process lipid transport;GO:0015132,molecular_function prostaglandin transmembrane transporter activity;GO:0015347,molecular_function sodium-independent organic anion transmembrane transporter activity;GO:0015732,biological_process prostaglandin transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043252,biological_process sodium-independent organic anion transport	NA	solute carrier organic anion transporter family member 2A1 [Source:HGNC Symbol%3BAcc:HGNC:10955]
ENSG00000143420	85.65	93.79	90.73	95.48	94.70	89.67	-0.0409557429865128	6.11051872678299	0.55613613275469	0.854794182254082	1:150600850-150629612:-	ENSA	22;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007584,biological_process response to nutrient;GO:0008200,molecular_function ion channel inhibitor activity;GO:0009749,biological_process response to glucose;GO:0019212,molecular_function phosphatase inhibitor activity;GO:0019870,molecular_function potassium channel inhibitor activity;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0035308,biological_process negative regulation of protein dephosphorylation;GO:0043086,biological_process negative regulation of catalytic activity;GO:0050790,biological_process regulation of catalytic activity;GO:0050796,biological_process regulation of insulin secretion;GO:0051301,biological_process cell division;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0065009,biological_process regulation of molecular function	NA	endosulfine alpha [Source:HGNC Symbol%3BAcc:HGNC:3360]
ENSG00000050165	135.62	137.05	126.31	134.66	126.61	130.40	0.0377088587680224	7.17106545157327	0.556365354978948	0.854887549501725	11:11963105-12009769:-	DKK3	13;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016055,biological_process Wnt signaling pathway;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030325,biological_process adrenal gland development;GO:0032348,biological_process negative regulation of aldosterone biosynthetic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1902613,biological_process negative regulation of anti-Mullerian hormone signaling pathway;GO:2000065,biological_process negative regulation of cortisol biosynthetic process	NA	dickkopf WNT signaling pathway inhibitor 3 [Source:HGNC Symbol%3BAcc:HGNC:2893]
ENSG00000173442	37.90	33.79	37.29	37.43	32.26	36.92	0.0442140580772539	7.3732508552086	0.556437426725553	0.854887549501725	11:65576037-65592650:+	EHBP1L1	4;GO:0003674,molecular_function molecular_function;GO:0005768,cellular_component endosome;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane	NA	EH domain binding protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:30682]
ENSG00000125534	210.03	240.28	225.71	234.96	221.57	244.94	-0.0438951448282868	6.59377372986291	0.556468779640914	0.854887549501725	20:63520723-63522206:+	PPDPF	4;GO:0001708,biological_process cell fate specification;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0031017,biological_process exocrine pancreas development	NA	pancreatic progenitor cell differentiation and proliferation factor [Source:HGNC Symbol%3BAcc:HGNC:16142]
ENSG00000197724	9.73	10.75	11.82	10.43	10.10	10.91	0.0495788473238359	5.13316039711122	0.556610054964248	0.854887549501725	9:93576406-93679587:+	PHF2	26;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001889,biological_process liver development;GO:0003713,molecular_function transcription coactivator activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006482,biological_process protein demethylation;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0035064,molecular_function methylated histone binding;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0061188,biological_process negative regulation of chromatin silencing at rDNA	NA	PHD finger protein 2 [Source:HGNC Symbol%3BAcc:HGNC:8920]
ENSG00000183580	7.00	7.46	6.94	7.16	6.43	6.92	0.0670675873331853	3.38301811284582	0.556625182992536	0.854887549501725	5:15500195-15939795:+	FBXL7	20;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0000278,biological_process mitotic cell cycle;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0010265,biological_process SCF complex assembly;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0051301,biological_process cell division	NA	F-box and leucine rich repeat protein 7 [Source:HGNC Symbol%3BAcc:HGNC:13604]
ENSG00000136271	47.39	48.02	46.64	49.63	46.02	51.47	-0.0397549850336302	6.45903700582808	0.556652165529385	0.854887549501725	7:44565416-44575051:-	DDX56	15;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0042254,biological_process ribosome biogenesis	NA	DEAD-box helicase 56 [Source:HGNC Symbol%3BAcc:HGNC:18193]
ENSG00000169093	30.90	28.78	27.18	30.18	25.08	29.40	0.0486073030859216	5.74019890936624	0.556678970645488	0.854887549501725	X:1403138-1453762:-	ASMTL	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0008168,molecular_function methyltransferase activity;GO:0008171,molecular_function O-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0047429,molecular_function nucleoside-triphosphate diphosphatase activity	NA	acetylserotonin O-methyltransferase like [Source:HGNC Symbol%3BAcc:HGNC:751]
ENSG00000132017	11.86	12.47	12.85	13.31	12.54	12.93	-0.0501678631835031	4.63321732196336	0.556794345028384	0.854958956560777	19:13952491-13961449:+	DCAF15	1;GO:0016567,biological_process protein ubiquitination	NA	DDB1 and CUL4 associated factor 15 [Source:HGNC Symbol%3BAcc:HGNC:25095]
ENSG00000104853	66.29	70.77	71.11	69.07	75.77	70.72	-0.0390535450465729	7.31219870141303	0.556979304291307	0.855137180478416	19:44954584-44993341:+	CLPTM1	8;GO:0005515,molecular_function protein binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0033081,biological_process regulation of T cell differentiation in thymus	NA	CLPTM1%2C transmembrane protein [Source:HGNC Symbol%3BAcc:HGNC:2087]
ENSG00000133678	12.92	12.40	11.29	11.82	12.64	14.52	-0.0817270563599951	3.12265644232032	0.557209622798043	0.855384992306716	10:80078645-80092557:+	TMEM254	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 254 [Source:HGNC Symbol%3BAcc:HGNC:25804]
ENSG00000104343	0.69	1.72	1.69	1.35	0.75	1.27	0.25689788271169	-0.152388437619875	0.557349676466802	0.855483384765798	8:73780096-73878910:-	UBE2W	21;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006513,biological_process protein monoubiquitination;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0071218,biological_process cellular response to misfolded protein	UBE2W, UBC16; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.25]; K10688	ubiquitin conjugating enzyme E2 W [Source:HGNC Symbol%3BAcc:HGNC:25616]
ENSG00000261221	6.00	6.35	7.18	6.48	6.02	6.42	0.0582920808681868	4.35916950030958	0.557411553692562	0.855483384765798	19:55605404-55617269:+	ZNF865	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 865 [Source:HGNC Symbol%3BAcc:HGNC:38705]
ENSG00000125691	1288.11	1288.10	1299.24	1304.46	1251.47	1262.49	0.0331401020669512	9.55728791823016	0.557789677099018	0.855957876354322	17:38847864-38853843:-	RPL23	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001223,molecular_function transcription coactivator binding;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032986,biological_process protein-DNA complex disassembly;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome;GO:0070180,molecular_function large ribosomal subunit rRNA binding;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0072717,biological_process cellular response to actinomycin D;GO:1901798,biological_process positive regulation of signal transduction by p53 class mediator;GO:1904667,biological_process negative regulation of ubiquitin protein ligase activity;GO:1990948,molecular_function ubiquitin ligase inhibitor activity;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	RP-L23e, RPL23; large subunit ribosomal protein L23e; K02894	ribosomal protein L23 [Source:HGNC Symbol%3BAcc:HGNC:10316]
ENSG00000160695	15.25	14.97	15.30	15.83	15.17	13.51	0.0454076565165006	5.64357591187867	0.558080210161412	0.856209977547735	11:119067691-119081978:+	VPS11	39;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005884,cellular_component actin filament;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006914,biological_process autophagy;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019904,molecular_function protein domain specific binding;GO:0019905,molecular_function syntaxin binding;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030139,cellular_component endocytic vesicle;GO:0030674,molecular_function protein binding, bridging;GO:0030897,cellular_component HOPS complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031647,biological_process regulation of protein stability;GO:0031902,cellular_component late endosome membrane;GO:0033263,cellular_component CORVET complex;GO:0034058,biological_process endosomal vesicle fusion;GO:0035542,biological_process regulation of SNARE complex assembly;GO:0046872,molecular_function metal ion binding;GO:1901998,biological_process toxin transport;GO:1902115,biological_process regulation of organelle assembly;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2000643,biological_process positive regulation of early endosome to late endosome transport	NA	VPS11%2C CORVET/HOPS core subunit [Source:HGNC Symbol%3BAcc:HGNC:14583]
ENSG00000163170	28.11	24.38	20.47	22.54	33.28	23.14	-0.0998037803498823	3.33389371468816	0.558091913988458	0.856209977547735	2:74135397-74147994:-	BOLA3	4;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process	NA	bolA family member 3 [Source:HGNC Symbol%3BAcc:HGNC:24415]
ENSG00000162849	1.44	0.90	1.30	1.24	1.02	1.17	0.113635289173058	2.94422469583524	0.558402069724824	0.8565799421026	1:245154984-245709431:+	KIF26B	14;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0007275,biological_process multicellular organism development;GO:0008017,molecular_function microtubule binding;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030010,biological_process establishment of cell polarity;GO:0072092,biological_process ureteric bud invasion	NA	kinesin family member 26B [Source:HGNC Symbol%3BAcc:HGNC:25484]
ENSG00000203499	0.71	0.59	0.91	0.88	1.11	0.59	-0.182734720592039	0.662796492109403	0.558839366124019	0.856936331847435	8:143734139-143790644:+	IQANK1	NA	NA	IQ motif and ankyrin repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:49576]
ENSG00000062370	2.78	3.01	2.64	2.71	2.96	2.34	0.0816914425745237	2.95883670344945	0.558876334351989	0.856936331847435	19:44326554-44367217:-	ZNF112	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 112 [Source:HGNC Symbol%3BAcc:HGNC:12892]
ENSG00000047410	35.00	39.16	36.76	35.02	38.26	35.51	0.039022255399866	8.06865245323406	0.558886000588499	0.856936331847435	1:186311651-186375693:-	TPR	67;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000189,biological_process MAPK import into nucleus;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0003674,molecular_function molecular_function;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0006110,biological_process regulation of glycolytic process;GO:0006404,biological_process RNA import into nucleus;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006999,biological_process nuclear pore organization;GO:0007049,biological_process cell cycle;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0008150,biological_process biological_process;GO:0010965,biological_process regulation of mitotic sister chromatid separation;GO:0015031,biological_process protein transport;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0019898,cellular_component extrinsic component of membrane;GO:0031072,molecular_function heat shock protein binding;GO:0031453,biological_process positive regulation of heterochromatin assembly;GO:0031965,cellular_component nuclear membrane;GO:0031990,biological_process mRNA export from nucleus in response to heat stress;GO:0034399,cellular_component nuclear periphery;GO:0034605,biological_process cellular response to heat;GO:0035457,biological_process cellular response to interferon-alpha;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042405,cellular_component nuclear inclusion body;GO:0042803,molecular_function protein homodimerization activity;GO:0043657,cellular_component host cell;GO:0044615,cellular_component nuclear pore nuclear basket;GO:0045947,biological_process negative regulation of translational initiation;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0046832,biological_process negative regulation of RNA export from nucleus;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051028,biological_process mRNA transport;GO:0051301,biological_process cell division;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070840,molecular_function dynein complex binding;GO:0070849,biological_process response to epidermal growth factor;GO:0072686,cellular_component mitotic spindle;GO:0075733,biological_process intracellular transport of virus;GO:0090267,biological_process positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:1900034,biological_process regulation of cellular response to heat;GO:1901673,biological_process regulation of mitotic spindle assembly	TPR, MLP1, MLP2; nucleoprotein TPR; K09291	translocated promoter region%2C nuclear basket protein [Source:HGNC Symbol%3BAcc:HGNC:12017]
ENSG00000156500	4.06	3.21	3.09	3.50	4.00	3.96	-0.124561360313965	1.67938009180699	0.558910540774739	0.856936331847435	X:134796788-134854610:+	FAM122C	NA	NA	family with sequence similarity 122C [Source:HGNC Symbol%3BAcc:HGNC:25202]
ENSG00000168389	3.25	2.64	3.21	3.26	3.40	3.24	-0.0951065191770529	2.41697650724439	0.559061351301777	0.856950983493308	1:39955111-39969968:+	MFSD2A	20;GO:0005548,molecular_function phospholipid transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0015245,molecular_function fatty acid transporter activity;GO:0015293,molecular_function symporter activity;GO:0015908,biological_process fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021766,biological_process hippocampus development;GO:0045056,biological_process transcytosis;GO:0051977,biological_process lysophospholipid transport;GO:0051978,molecular_function lysophospholipid transporter activity;GO:0055085,biological_process transmembrane transport;GO:0060856,biological_process establishment of blood-brain barrier;GO:1990379,biological_process lipid transport across blood brain barrier	NA	major facilitator superfamily domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:25897]
ENSG00000129932	8.73	10.44	10.07	10.08	11.47	9.62	-0.0860184140161847	3.21043321091464	0.559087499305881	0.856950983493308	19:3490821-3500940:-	DOHH	9;GO:0004497,molecular_function monooxygenase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0008612,biological_process peptidyl-lysine modification to peptidyl-hypusine;GO:0016491,molecular_function oxidoreductase activity;GO:0019135,molecular_function deoxyhypusine monooxygenase activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	deoxyhypusine hydroxylase [Source:HGNC Symbol%3BAcc:HGNC:28662]
ENSG00000198783	22.15	20.72	21.10	18.45	20.39	23.19	0.0568525123159959	4.56225412418507	0.5591272065828	0.856950983493308	17:34961529-34963775:+	ZNF830	23;GO:0000278,biological_process mitotic cell cycle;GO:0001541,biological_process ovarian follicle development;GO:0001546,biological_process preantral ovarian follicle growth;GO:0001832,biological_process blastocyst growth;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0016607,cellular_component nuclear speck;GO:0033260,biological_process nuclear DNA replication;GO:0033314,biological_process mitotic DNA replication checkpoint;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044773,biological_process mitotic DNA damage checkpoint;GO:0046872,molecular_function metal ion binding;GO:0048478,biological_process replication fork protection;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0060729,biological_process intestinal epithelial structure maintenance	NA	zinc finger protein 830 [Source:HGNC Symbol%3BAcc:HGNC:28291]
ENSG00000069849	101.40	114.04	91.21	93.02	102.63	103.09	0.0470366796435694	6.59490436104552	0.559251372045698	0.857035466815216	3:141876123-141926514:+	ATP1B3	32;GO:0001671,molecular_function ATPase activator activity;GO:0005391,molecular_function sodium:potassium-exchanging ATPase activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005890,cellular_component sodium:potassium-exchanging ATPase complex;GO:0005901,cellular_component caveola;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0010107,biological_process potassium ion import;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0030007,biological_process cellular potassium ion homeostasis;GO:0032781,biological_process positive regulation of ATPase activity;GO:0034220,biological_process ion transmembrane transport;GO:0036376,biological_process sodium ion export from cell;GO:0042470,cellular_component melanosome;GO:0050821,biological_process protein stabilization;GO:0050900,biological_process leukocyte migration;GO:0051117,molecular_function ATPase binding;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane;GO:0086009,biological_process membrane repolarization;GO:0090662,biological_process ATP hydrolysis coupled transmembrane transport;GO:1901018,biological_process positive regulation of potassium ion transmembrane transporter activity;GO:1903278,biological_process positive regulation of sodium ion export from cell;GO:1903288,biological_process positive regulation of potassium ion import;GO:1903779,biological_process regulation of cardiac conduction	ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta; K01540	ATPase Na+/K+ transporting subunit beta 3 [Source:HGNC Symbol%3BAcc:HGNC:806]
ENSG00000117362	152.07	146.15	140.88	148.72	153.20	152.28	-0.0368981307760677	6.90435894447341	0.559374408225767	0.857118198902167	1:150265398-150269580:-	APH1A	23;GO:0001656,biological_process metanephros development;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0032580,cellular_component Golgi cisterna membrane;GO:0034205,biological_process beta-amyloid formation;GO:0042982,biological_process amyloid precursor protein metabolic process;GO:0042987,biological_process amyloid precursor protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0070765,cellular_component gamma-secretase complex	APH1A; gamma-secretase subunit APH-1A; K06172	aph-1 homolog A%2C gamma-secretase subunit [Source:HGNC Symbol%3BAcc:HGNC:29509]
ENSG00000181392	1.31	0.92	1.54	1.02	0.92	1.42	0.197652179580567	0.71867175728363	0.559529306200225	0.857130710238604	19:36003306-36008793:-	SYNE4	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031309,cellular_component integral component of nuclear outer membrane;GO:0045198,biological_process establishment of epithelial cell apical/basal polarity	NA	spectrin repeat containing nuclear envelope family member 4 [Source:HGNC Symbol%3BAcc:HGNC:26703]
ENSG00000186283	14.47	13.80	14.53	14.56	14.29	12.68	0.0595593888217848	4.24451218256477	0.559576850526698	0.857130710238604	1:179081376-179098023:+	TOR3A	7;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0016887,molecular_function ATPase activity;GO:0070062,cellular_component extracellular exosome	NA	torsin family 3 member A [Source:HGNC Symbol%3BAcc:HGNC:11997]
ENSG00000119778	2.30	1.82	2.13	2.02	2.57	2.13	-0.0800367791803069	3.2970484563473	0.55961305345903	0.857130710238604	2:23748663-23927114:-	ATAD2B	9;GO:0000166,molecular_function nucleotide binding;GO:0003682,molecular_function chromatin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016887,molecular_function ATPase activity;GO:0031936,biological_process negative regulation of chromatin silencing;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070577,molecular_function lysine-acetylated histone binding	NA	ATPase family%2C AAA domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:29230]
ENSG00000125356	272.41	254.39	241.48	283.09	249.56	265.87	-0.0434497486751094	5.782523711286	0.559718414580411	0.857130710238604	X:119871486-119876662:+	NDUFA1	12;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005829,cellular_component cytosol;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1; K03945	NADH:ubiquinone oxidoreductase subunit A1 [Source:HGNC Symbol%3BAcc:HGNC:7683]
ENSG00000183395	14.98	19.69	16.80	22.08	15.47	17.76	-0.102596253479089	3.15866028387021	0.559763658321923	0.857130710238604	12:102196458-102197845:-	PMCH	10;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0007218,biological_process neuropeptide signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007631,biological_process feeding behavior;GO:0030154,biological_process cell differentiation;GO:0030354,molecular_function melanin-concentrating hormone activity	PMCH; pro-melanin-concentrating hormone; K05229	pro-melanin concentrating hormone [Source:HGNC Symbol%3BAcc:HGNC:9109]
ENSG00000125945	27.40	23.99	24.32	25.28	21.41	26.88	0.054940516778494	5.14161284702945	0.559796879715166	0.857130710238604	1:23359447-23369442:-	ZNF436	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 436 [Source:HGNC Symbol%3BAcc:HGNC:20814]
ENSG00000168310	11.84	11.53	15.23	14.38	13.31	13.23	-0.0662894457123111	4.09731835629334	0.559891851928712	0.857170394424162	4:184387712-184474580:-	IRF2	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000975,molecular_function regulatory region DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007596,biological_process blood coagulation;GO:0008283,biological_process cell proliferation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway	NA	interferon regulatory factor 2 [Source:HGNC Symbol%3BAcc:HGNC:6117]
ENSG00000105767	2.73	2.38	2.09	2.25	3.06	2.66	-0.131575267440592	1.63351160850824	0.560063144427852	0.857326897494504	19:43622367-43639839:-	CADM4	13;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008037,biological_process cell recognition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0050839,molecular_function cell adhesion molecule binding;GO:0070062,cellular_component extracellular exosome	NA	cell adhesion molecule 4 [Source:HGNC Symbol%3BAcc:HGNC:30825]
ENSG00000186174	38.10	36.38	40.51	36.96	37.32	38.72	0.0378447111995937	7.41943396784884	0.560245667787461	0.85736862834848	11:118893874-118925608:-	BCL9L	16;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008013,molecular_function beta-catenin binding;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060070,biological_process canonical Wnt signaling pathway;GO:1903506,biological_process regulation of nucleic acid-templated transcription;GO:1904837,biological_process beta-catenin-TCF complex assembly	NA	B-cell CLL/lymphoma 9 like [Source:HGNC Symbol%3BAcc:HGNC:23688]
ENSG00000135916	68.07	75.78	71.67	75.28	72.63	75.24	-0.0405595730264211	6.57200350008341	0.560297455612015	0.85736862834848	2:230864638-230879248:+	ITM2C	15;GO:0001540,molecular_function beta-amyloid binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030182,biological_process neuron differentiation;GO:0042985,biological_process negative regulation of amyloid precursor protein biosynthetic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	NA	integral membrane protein 2C [Source:HGNC Symbol%3BAcc:HGNC:6175]
ENSG00000146457	72.78	66.83	74.72	75.77	70.00	76.63	-0.0398061326308258	6.5085470678038	0.560297616463617	0.85736862834848	6:159725584-159756319:+	WTAP	12;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0008380,biological_process RNA splicing;GO:0016070,biological_process RNA metabolic process;GO:0016607,cellular_component nuclear speck;GO:0031965,cellular_component nuclear membrane;GO:0036396,cellular_component MIS complex;GO:0080009,biological_process mRNA methylation	NA	WT1 associated protein [Source:HGNC Symbol%3BAcc:HGNC:16846]
ENSG00000160345	9.34	11.65	8.21	8.97	13.01	9.88	-0.127027388533114	2.33554322758037	0.560448269817877	0.857474890256357	9:135495180-135501734:-	C9orf116	1;GO:0005515,molecular_function protein binding	NA	chromosome 9 open reading frame 116 [Source:HGNC Symbol%3BAcc:HGNC:28435]
ENSG00000184786	0.71	1.77	1.12	1.51	1.79	1.07	-0.313199754061961	-0.112102202817541	0.560551218422711	0.857474890256357	6:169740113-169751587:-	TCTE3	7;GO:0003774,molecular_function motor activity;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0030286,cellular_component dynein complex	NA	t-complex-associated-testis-expressed 3 [Source:HGNC Symbol%3BAcc:HGNC:11695]
ENSG00000184956	0.35	0.41	0.31	0.43	0.28	0.26	0.15053083367281	1.44674534578712	0.560616854482637	0.857474890256357	11:1012820-1036706:-	MUC6	7;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0016266,biological_process O-glycan processing;GO:0030277,biological_process maintenance of gastrointestinal epithelium	NA	mucin 6%2C oligomeric mucus/gel-forming [Source:HGNC Symbol%3BAcc:HGNC:7517]
ENSG00000141258	31.67	30.67	32.99	31.51	32.00	30.15	0.0385465099373907	6.74428351508459	0.560690094501463	0.857474890256357	17:2337497-2381058:+	SGSM2	10;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0034499,biological_process late endosome to Golgi transport;GO:0042470,cellular_component melanosome;GO:0043547,biological_process positive regulation of GTPase activity;GO:0090630,biological_process activation of GTPase activity	NA	small G protein signaling modulator 2 [Source:HGNC Symbol%3BAcc:HGNC:29026]
ENSG00000108588	61.79	69.50	60.17	60.57	64.70	62.03	0.0409983371057848	6.58415757371548	0.560765431583983	0.857474890256357	17:63745249-63776351:-	CCDC47	13;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0006983,biological_process ER overload response;GO:0007029,biological_process endoplasmic reticulum organization;GO:0009791,biological_process post-embryonic development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0055074,biological_process calcium ion homeostasis	NA	coiled-coil domain containing 47 [Source:HGNC Symbol%3BAcc:HGNC:24856]
ENSG00000126106	8.65	9.52	7.18	7.68	8.38	7.91	0.082164583324138	3.06557603833869	0.560788128133905	0.857474890256357	1:44635237-44674555:-	TMEM53	3;GO:0005634,cellular_component nucleus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 53 [Source:HGNC Symbol%3BAcc:HGNC:26186]
ENSG00000100376	24.37	19.48	22.50	22.27	21.35	20.97	0.0588516492772053	4.72000759111807	0.56086225427693	0.857474890256357	22:45308967-45341955:+	FAM118A	4;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042802,molecular_function identical protein binding	NA	family with sequence similarity 118 member A [Source:HGNC Symbol%3BAcc:HGNC:1313]
ENSG00000066583	12.96	13.47	11.28	13.82	13.32	12.66	-0.0712979615380011	3.54688365024863	0.561024565613397	0.857474890256357	5:129094750-129114028:+	ISOC1	8;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process;GO:0070062,cellular_component extracellular exosome	NA	isochorismatase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24254]
ENSG00000107140	14.03	12.57	16.46	15.95	14.94	14.42	-0.0551656768452482	4.80195889100614	0.561027926916708	0.857474890256357	9:35605304-35610041:+	TESK1	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007283,biological_process spermatogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	testis-specific kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:11731]
ENSG00000100024	0.84	0.92	0.82	1.11	0.62	0.47	0.239682782328155	0.282760879247257	0.56105784731025	0.857474890256357	22:24494106-24528390:+	UPB1	12;GO:0003824,molecular_function catalytic activity;GO:0003837,molecular_function beta-ureidopropionase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006807,biological_process nitrogen compound metabolic process;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0019483,biological_process beta-alanine biosynthetic process;GO:0046135,biological_process pyrimidine nucleoside catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	UPB1, pydC; beta-ureidopropionase [EC:3.5.1.6]; K01431	beta-ureidopropionase 1 [Source:HGNC Symbol%3BAcc:HGNC:16297]
ENSG00000171223	67.91	48.01	72.12	63.80	43.79	70.59	0.0914251190794797	5.99874168901268	0.561340025397516	0.857732174820305	19:12791495-12793315:+	JUNB	43;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001570,biological_process vasculogenesis;GO:0001649,biological_process osteoblast differentiation;GO:0001701,biological_process in utero embryonic development;GO:0001829,biological_process trophectodermal cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0009314,biological_process response to radiation;GO:0009612,biological_process response to mechanical stimulus;GO:0009987,biological_process cellular process;GO:0010941,biological_process regulation of cell death;GO:0030316,biological_process osteoclast differentiation;GO:0032496,biological_process response to lipopolysaccharide;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033687,biological_process osteoblast proliferation;GO:0034097,biological_process response to cytokine;GO:0035976,cellular_component AP1 complex;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046697,biological_process decidualization;GO:0051591,biological_process response to cAMP;GO:0051726,biological_process regulation of cell cycle;GO:0060136,biological_process embryonic process involved in female pregnancy;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0071277,biological_process cellular response to calcium ion	JUNB; transcription factor jun-B; K09028	JunB proto-oncogene%2C AP-1 transcription factor subunit [Source:HGNC Symbol%3BAcc:HGNC:6205]
ENSG00000100802	14.05	13.03	14.50	13.08	12.83	14.51	0.0554959578055615	4.47600578486419	0.561364391222118	0.857732174820305	14:22985907-23010166:-	C14orf93	3;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region	NA	chromosome 14 open reading frame 93 [Source:HGNC Symbol%3BAcc:HGNC:20162]
ENSG00000076108	22.49	22.17	22.04	22.73	21.46	21.38	0.0366747054203921	6.98531652460635	0.561546795860144	0.857737261433994	12:56595595-56636816:-	BAZ2A	21;GO:0000183,biological_process chromatin silencing at rDNA;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005677,cellular_component chromatin silencing complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006306,biological_process DNA methylation;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016607,cellular_component nuclear speck;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0033553,cellular_component rDNA heterochromatin;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding;GO:0070577,molecular_function lysine-acetylated histone binding	NA	bromodomain adjacent to zinc finger domain 2A [Source:HGNC Symbol%3BAcc:HGNC:962]
ENSG00000180914	1.76	1.23	1.64	1.60	1.56	2.17	-0.177068560910975	1.0796102069795	0.561609834211201	0.857737261433994	3:8750407-8769628:-	OXTR	57;GO:0001967,biological_process suckling behavior;GO:0001975,biological_process response to amphetamine;GO:0001992,biological_process regulation of systemic arterial blood pressure by vasopressin;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004990,molecular_function oxytocin receptor activity;GO:0005000,molecular_function vasopressin receptor activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005902,cellular_component microvillus;GO:0005913,cellular_component cell-cell adherens junction;GO:0006936,biological_process muscle contraction;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007507,biological_process heart development;GO:0007565,biological_process female pregnancy;GO:0007595,biological_process lactation;GO:0007613,biological_process memory;GO:0010701,biological_process positive regulation of norepinephrine secretion;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017046,molecular_function peptide hormone binding;GO:0021537,biological_process telencephalon development;GO:0030431,biological_process sleep;GO:0032230,biological_process positive regulation of synaptic transmission, GABAergic;GO:0032355,biological_process response to estradiol;GO:0032570,biological_process response to progesterone;GO:0032870,biological_process cellular response to hormone stimulus;GO:0034059,biological_process response to anoxia;GO:0034097,biological_process response to cytokine;GO:0035176,biological_process social behavior;GO:0042220,biological_process response to cocaine;GO:0042277,molecular_function peptide binding;GO:0042493,biological_process response to drug;GO:0042711,biological_process maternal behavior;GO:0042713,biological_process sperm ejaculation;GO:0042755,biological_process eating behavior;GO:0043434,biological_process response to peptide hormone;GO:0044058,biological_process regulation of digestive system process;GO:0044849,biological_process estrous cycle;GO:0045777,biological_process positive regulation of blood pressure;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0048545,biological_process response to steroid hormone;GO:0048565,biological_process digestive tract development;GO:0051965,biological_process positive regulation of synapse assembly;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060137,biological_process maternal process involved in parturition;GO:0060406,biological_process positive regulation of penile erection;GO:0060455,biological_process negative regulation of gastric acid secretion;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070474,biological_process positive regulation of uterine smooth muscle contraction;GO:1901652,biological_process response to peptide	OXTR; oxytocin receptor; K04229	oxytocin receptor [Source:HGNC Symbol%3BAcc:HGNC:8529]
ENSG00000172172	157.52	173.77	150.92	167.27	167.17	165.13	-0.0420155504749519	6.4515530510314	0.56165742420706	0.857737261433994	8:120380760-120445402:-	MRPL13	13;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L13, MRPL13, rplM; large subunit ribosomal protein L13; K02871	mitochondrial ribosomal protein L13 [Source:HGNC Symbol%3BAcc:HGNC:14278]
ENSG00000126216	6.03	6.36	6.49	6.16	5.83	6.32	0.0533430504852193	4.18767382735741	0.561691139874166	0.857737261433994	13:112485004-112588167:-	TUBGCP3	26;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000922,cellular_component spindle pole;GO:0000923,cellular_component equatorial microtubule organizing center;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005827,cellular_component polar microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007020,biological_process microtubule nucleation;GO:0007338,biological_process single fertilization;GO:0008275,cellular_component gamma-tubulin small complex;GO:0016020,cellular_component membrane;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0043015,molecular_function gamma-tubulin binding;GO:0051011,molecular_function microtubule minus-end binding;GO:0051298,biological_process centrosome duplication;GO:0051321,biological_process meiotic cell cycle;GO:0051415,biological_process interphase microtubule nucleation by interphase microtubule organizing center;GO:0090307,biological_process mitotic spindle assembly	NA	tubulin gamma complex associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:18598]
ENSG00000160208	14.60	13.87	14.18	15.18	13.54	15.71	-0.0467738483632093	5.05334930704442	0.561713219866023	0.857737261433994	21:43659547-43696079:+	RRP1B	10;GO:0000791,cellular_component euchromatin;GO:0000792,cellular_component heterochromatin;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0030688,cellular_component preribosome, small subunit precursor	NA	ribosomal RNA processing 1B [Source:HGNC Symbol%3BAcc:HGNC:23818]
ENSG00000133818	80.27	87.38	73.90	83.49	81.43	85.57	-0.0446762423909652	5.94000459880639	0.561977876030488	0.857743125353882	11:14277925-14364506:-	RRAS2	16;GO:0000166,molecular_function nucleotide binding;GO:0001649,biological_process osteoblast differentiation;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0009987,biological_process cellular process;GO:0016020,cellular_component membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0070062,cellular_component extracellular exosome;GO:1901214,biological_process regulation of neuron death	RRAS2, TC21; Ras-related protein R-Ras2; K07830	related RAS viral (r-ras) oncogene homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:17271]
ENSG00000011376	7.22	8.11	6.44	6.66	8.76	7.55	-0.0713717264297942	4.34461017944153	0.561978433383841	0.857743125353882	3:45388505-45549421:+	LARS2	13;GO:0000166,molecular_function nucleotide binding;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004823,molecular_function leucine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006429,biological_process leucyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0016874,molecular_function ligase activity;GO:0032543,biological_process mitochondrial translation	LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]; K01869	leucyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:17095]
ENSG00000144488	0.66	1.03	0.77	0.65	0.44	1.06	0.173470542621571	1.47289034389929	0.561992637089659	0.857743125353882	2:238100156-238133287:+	ESPNL	4;GO:0005737,cellular_component cytoplasm;GO:0031941,cellular_component filamentous actin;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly	NA	espin like [Source:HGNC Symbol%3BAcc:HGNC:27937]
ENSG00000186468	578.42	537.45	536.10	598.30	524.45	589.38	-0.0396640268510109	8.27815920054261	0.561993461572796	0.857743125353882	5:82273357-82278577:-	RPS23	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0018126,biological_process protein hydroxylation;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	ribosomal protein S23 [Source:HGNC Symbol%3BAcc:HGNC:10410]
ENSG00000272602	4.40	5.18	5.78	5.20	4.42	4.99	0.0814046812487727	3.32201657554987	0.562416385838488	0.857865079216326	4:53284-88211:+	ZNF595	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 595 [Source:HGNC Symbol%3BAcc:HGNC:27196]
ENSG00000141965	7.18	8.19	7.88	7.39	8.73	8.34	-0.0664437083534964	4.00890252394198	0.562427055832263	0.857865079216326	19:4791680-4801273:+	FEM1A	8;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0031867,molecular_function EP4 subtype prostaglandin E2 receptor binding;GO:0043687,biological_process post-translational protein modification;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051438,biological_process regulation of ubiquitin-protein transferase activity	NA	fem-1 homolog A [Source:HGNC Symbol%3BAcc:HGNC:16934]
ENSG00000108061	28.07	26.00	30.01	29.37	28.19	29.84	-0.0407338307759812	5.64818723112505	0.562456416175874	0.857865079216326	10:110919546-111013667:+	SHOC2	13;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007265,biological_process Ras protein signal transduction;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0019903,molecular_function protein phosphatase binding;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0050790,biological_process regulation of catalytic activity	NA	SHOC2%2C leucine rich repeat scaffold protein [Source:HGNC Symbol%3BAcc:HGNC:15454]
ENSG00000101935	13.43	16.36	14.22	15.51	14.65	16.05	-0.0700132625657587	3.92072170872346	0.562466732520539	0.857865079216326	X:110194185-110440233:-	AMMECR1	5;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process	NA	Alport syndrome%2C mental retardation%2C midface hypoplasia and elliptocytosis chromosomal region gene 1 [Source:HGNC Symbol%3BAcc:HGNC:467]
ENSG00000123739	33.13	38.77	36.61	38.82	36.65	37.83	-0.057427146079584	4.39859913526943	0.562473520087036	0.857865079216326	4:109709988-109730077:-	PLA2G12A	21;GO:0004623,molecular_function phospholipase A2 activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008150,biological_process biological_process;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0036149,biological_process phosphatidylinositol acyl-chain remodeling;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0046872,molecular_function metal ion binding;GO:0047498,molecular_function calcium-dependent phospholipase A2 activity;GO:0050482,biological_process arachidonic acid secretion	PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]; K01047	phospholipase A2 group XIIA [Source:HGNC Symbol%3BAcc:HGNC:18554]
ENSG00000133773	36.28	30.39	32.49	33.14	34.61	36.04	-0.0484483494855931	4.77391489237283	0.562488027047585	0.857865079216326	12:82223680-82358805:-	CCDC59	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0044267,biological_process cellular protein metabolic process	NA	coiled-coil domain containing 59 [Source:HGNC Symbol%3BAcc:HGNC:25005]
ENSG00000165502	274.73	302.62	268.48	263.23	281.90	283.26	0.0392771202782299	6.47363773461464	0.562664506188536	0.857984681983092	14:49618518-49620685:-	RPL36AL	11;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L44e, RPL44; large subunit ribosomal protein L44e; K02929	ribosomal protein L36a like [Source:HGNC Symbol%3BAcc:HGNC:10346]
ENSG00000175854	36.69	39.38	35.28	40.13	35.37	32.54	0.052678011920318	4.95810791839438	0.562704688312604	0.857984681983092	9:128275378-128288990:+	SWI5	8;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000730,biological_process DNA recombinase assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0032798,cellular_component Swi5-Sfr1 complex;GO:0071479,biological_process cellular response to ionizing radiation	NA	SWI5 homologous recombination repair protein [Source:HGNC Symbol%3BAcc:HGNC:31412]
ENSG00000227345	8.59	8.32	8.19	8.46	7.85	8.17	0.0486804194242885	4.60653438706747	0.562905867897959	0.85818601550201	10:49818278-49970203:-	PARG	12;GO:0004649,molecular_function poly(ADP-ribose) glycohydrolase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:1990966,biological_process ATP generation from poly-ADP-D-ribose	NA	poly(ADP-ribose) glycohydrolase [Source:HGNC Symbol%3BAcc:HGNC:8605]
ENSG00000197958	2485.46	2370.41	2469.13	2611.44	2387.89	2567.11	-0.0349581503050104	10.2638294391798	0.563074292690843	0.858337368926861	9:127447673-127451405:-	RPL12	19;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	RP-L12e, RPL12; large subunit ribosomal protein L12e; K02870	ribosomal protein L12 [Source:HGNC Symbol%3BAcc:HGNC:10302]
ENSG00000244045	18.31	16.08	14.42	16.52	19.19	16.28	-0.0757719556347005	3.46660189388648	0.563256132358659	0.858468038042155	17:28357580-28363683:+	TMEM199	13;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007042,biological_process lysosomal lumen acidification;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0036295,biological_process cellular response to increased oxygen levels;GO:1905146,biological_process lysosomal protein catabolic process	NA	transmembrane protein 199 [Source:HGNC Symbol%3BAcc:HGNC:18085]
ENSG00000175893	7.64	7.93	9.17	7.72	9.83	9.11	-0.0938692341369975	2.80262752107666	0.563298329964824	0.858468038042155	9:14611070-14693471:-	ZDHHC21	14;GO:0000139,cellular_component Golgi membrane;GO:0001942,biological_process hair follicle development;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018230,biological_process peptidyl-L-cysteine S-palmitoylation;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0048733,biological_process sebaceous gland development;GO:0050999,biological_process regulation of nitric-oxide synthase activity	NA	zinc finger DHHC-type containing 21 [Source:HGNC Symbol%3BAcc:HGNC:20750]
ENSG00000215421	1.87	2.10	2.02	1.98	1.91	1.89	0.0579706416109651	3.77581717128365	0.563485679701025	0.858648139225243	18:74597869-75065671:+	ZNF407	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 407 [Source:HGNC Symbol%3BAcc:HGNC:19904]
ENSG00000261115	5.68	5.82	5.36	6.51	7.42	4.51	-0.115361433022065	2.47307859472786	0.564258385146253	0.859518897145269	7:141074231-141480380:+	TMEM178B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 178B [Source:HGNC Symbol%3BAcc:HGNC:44112]
ENSG00000080845	17.58	16.64	19.26	19.16	18.91	17.55	-0.0414797663765994	5.84184136385627	0.564331851435724	0.859518897145269	20:36306335-36528637:+	DLGAP4	7;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0023052,biological_process signaling;GO:0045202,cellular_component synapse	NA	DLG associated protein 4 [Source:HGNC Symbol%3BAcc:HGNC:24476]
ENSG00000066427	13.13	11.58	14.08	13.11	14.81	13.02	-0.0572875613651801	4.12352512917209	0.564451274133923	0.859518897145269	14:92038651-92106621:-	ATXN3	43;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006289,biological_process nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010810,biological_process regulation of cell-substrate adhesion;GO:0016363,cellular_component nuclear matrix;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0034605,biological_process cellular response to heat;GO:0035520,biological_process monoubiquitinated protein deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042405,cellular_component nuclear inclusion body;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0051117,molecular_function ATPase binding;GO:0061578,molecular_function Lys63-specific deubiquitinase activity;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0071218,biological_process cellular response to misfolded protein;GO:1904294,biological_process positive regulation of ERAD pathway;GO:1904379,biological_process protein localization to cytosolic proteasome complex involved in ERAD pathway;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	ATXN3, MJD; Ataxin-3 [EC:3.4.22.-]; K11863	ataxin 3 [Source:HGNC Symbol%3BAcc:HGNC:7106]
ENSG00000273604	1.68	2.10	1.55	1.19	1.47	2.04	0.169510811992805	1.02866663831854	0.564456271687917	0.859518897145269	17:38671702-38675421:-	EPOP	9;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0035098,cellular_component ESC/E(Z) complex;GO:0035616,biological_process histone H2B conserved C-terminal lysine deubiquitination;GO:0048663,biological_process neuron fate commitment;GO:0048863,biological_process stem cell differentiation;GO:0070449,cellular_component elongin complex	NA	elongin BC and polycomb repressive complex 2 associated protein [Source:HGNC Symbol%3BAcc:HGNC:34493]
ENSG00000106723	62.36	55.93	61.33	62.39	61.66	62.45	-0.0383030919315703	5.59098272394472	0.564515063955449	0.859518897145269	9:88388418-88478694:+	SPIN1	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007276,biological_process gamete generation;GO:0009303,biological_process rRNA transcription;GO:0016055,biological_process Wnt signaling pathway;GO:0016569,biological_process covalent chromatin modification;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0031965,cellular_component nuclear membrane;GO:0035064,molecular_function methylated histone binding;GO:0051321,biological_process meiotic cell cycle	NA	spindlin 1 [Source:HGNC Symbol%3BAcc:HGNC:11243]
ENSG00000113721	0.27	0.14	0.22	0.34	0.14	0.31	-0.259384571002346	-0.0556895823139173	0.564536796258209	0.859518897145269	5:150113836-150155872:-	PDGFRB	108;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0004992,molecular_function platelet activating factor receptor activity;GO:0005017,molecular_function platelet-derived growth factor-activated receptor activity;GO:0005019,molecular_function platelet-derived growth factor beta-receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006468,biological_process protein phosphorylation;GO:0006935,biological_process chemotaxis;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007568,biological_process aging;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0009636,biological_process response to toxic substance;GO:0009986,cellular_component cell surface;GO:0010863,biological_process positive regulation of phospholipase C activity;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070,biological_process response to organic cyclic compound;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030335,biological_process positive regulation of cell migration;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032355,biological_process response to estradiol;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0032526,biological_process response to retinoic acid;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0033993,biological_process response to lipid;GO:0034405,biological_process response to fluid shear stress;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035441,biological_process cell migration involved in vasculogenesis;GO:0035556,biological_process intracellular signal transduction;GO:0035789,biological_process metanephric mesenchymal cell migration;GO:0035791,biological_process platelet-derived growth factor receptor-beta signaling pathway;GO:0035793,biological_process positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0035909,biological_process aorta morphogenesis;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0038085,molecular_function vascular endothelial growth factor binding;GO:0038091,biological_process positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042060,biological_process wound healing;GO:0042542,biological_process response to hydrogen peroxide;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043202,cellular_component lysosomal lumen;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043548,molecular_function phosphatidylinositol 3-kinase binding;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0043627,biological_process response to estrogen;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048407,molecular_function platelet-derived growth factor binding;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048839,biological_process inner ear development;GO:0050921,biological_process positive regulation of chemotaxis;GO:0055003,biological_process cardiac myofibril assembly;GO:0055093,biological_process response to hyperoxia;GO:0060326,biological_process cell chemotaxis;GO:0060437,biological_process lung growth;GO:0060981,biological_process cell migration involved in coronary angiogenesis;GO:0061298,biological_process retina vasculature development in camera-type eye;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071670,biological_process smooth muscle cell chemotaxis;GO:0072075,biological_process metanephric mesenchyme development;GO:0072262,biological_process metanephric glomerular mesangial cell proliferation involved in metanephros development;GO:0072275,biological_process metanephric glomerulus morphogenesis;GO:0072277,biological_process metanephric glomerular capillary formation;GO:0072278,biological_process metanephric comma-shaped body morphogenesis;GO:0072284,biological_process metanephric S-shaped body morphogenesis;GO:0090280,biological_process positive regulation of calcium ion import;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2000491,biological_process positive regulation of hepatic stellate cell activation;GO:2000573,biological_process positive regulation of DNA biosynthetic process;GO:2000587,biological_process negative regulation of platelet-derived growth factor receptor-beta signaling pathway	PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]; K05089	platelet derived growth factor receptor beta [Source:HGNC Symbol%3BAcc:HGNC:8804]
ENSG00000102158	43.78	41.90	38.09	37.94	42.79	40.18	0.0452373572754427	5.50949668232166	0.564606681150221	0.859518897145269	X:77826363-77895593:-	MAGT1	19;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006810,biological_process transport;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0050890,biological_process cognition;GO:0055085,biological_process transmembrane transport;GO:1903830,biological_process magnesium ion transmembrane transport	NA	magnesium transporter 1 [Source:HGNC Symbol%3BAcc:HGNC:28880]
ENSG00000164011	10.09	10.59	8.65	8.51	10.32	9.16	0.0737789564895428	3.31546500932663	0.564611059963145	0.859518897145269	1:42846572-42852477:+	ZNF691	4;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 691 [Source:HGNC Symbol%3BAcc:HGNC:28028]
ENSG00000101152	30.62	27.62	34.48	31.22	29.73	28.97	0.0637550400276319	4.21137729093305	0.564725495864454	0.859587686102449	20:63895181-63936031:+	DNAJC5	18;GO:0005739,cellular_component mitochondrion;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0007269,biological_process neurotransmitter secretion;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0042470,cellular_component melanosome;GO:0043008,molecular_function ATP-dependent protein binding;GO:0043195,cellular_component terminal bouton;GO:0043312,biological_process neutrophil degranulation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045055,biological_process regulated exocytosis;GO:0061202,cellular_component clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0070062,cellular_component extracellular exosome	NA	DnaJ heat shock protein family (Hsp40) member C5 [Source:HGNC Symbol%3BAcc:HGNC:16235]
ENSG00000164118	7.99	7.91	7.58	7.66	7.82	7.08	0.0709387219337761	3.31823902796136	0.564828619301294	0.859639241219588	4:174283676-174333380:+	CEP44	7;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0030496,cellular_component midbody	NA	centrosomal protein 44 [Source:HGNC Symbol%3BAcc:HGNC:29356]
ENSG00000007372	9.40	9.48	11.90	9.81	9.17	10.70	0.0667834867385018	4.26276314973124	0.56511465764141	0.859969136361754	11:31784778-31818062:-	PAX6	101;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001568,biological_process blood vessel development;GO:0001654,biological_process eye development;GO:0001709,biological_process cell fate determination;GO:0001764,biological_process neuron migration;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002088,biological_process lens development in camera-type eye;GO:0003002,biological_process regionalization;GO:0003309,biological_process type B pancreatic cell differentiation;GO:0003322,biological_process pancreatic A cell development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0007435,biological_process salivary gland morphogenesis;GO:0007601,biological_process visual perception;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009611,biological_process response to wounding;GO:0009786,biological_process regulation of asymmetric cell division;GO:0009887,biological_process organ morphogenesis;GO:0009950,biological_process dorsal/ventral axis specification;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0019901,molecular_function protein kinase binding;GO:0021543,biological_process pallium development;GO:0021778,biological_process oligodendrocyte cell fate specification;GO:0021796,biological_process cerebral cortex regionalization;GO:0021798,biological_process forebrain dorsal/ventral pattern formation;GO:0021902,biological_process commitment of neuronal cell to specific neuron type in forebrain;GO:0021905,biological_process forebrain-midbrain boundary formation;GO:0021912,biological_process regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification;GO:0021913,biological_process regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification;GO:0021918,biological_process regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment;GO:0021978,biological_process telencephalon regionalization;GO:0021983,biological_process pituitary gland development;GO:0021986,biological_process habenula development;GO:0023019,biological_process signal transduction involved in regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030334,biological_process regulation of cell migration;GO:0030858,biological_process positive regulation of epithelial cell differentiation;GO:0030900,biological_process forebrain development;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032808,biological_process lacrimal gland development;GO:0033365,biological_process protein localization to organelle;GO:0035035,molecular_function histone acetyltransferase binding;GO:0042462,biological_process eye photoreceptor cell development;GO:0042593,biological_process glucose homeostasis;GO:0043010,biological_process camera-type eye development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045165,biological_process cell fate commitment;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048505,biological_process regulation of timing of cell differentiation;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0048663,biological_process neuron fate commitment;GO:0048708,biological_process astrocyte differentiation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050767,biological_process regulation of neurogenesis;GO:0050768,biological_process negative regulation of neurogenesis;GO:0060041,biological_process retina development in camera-type eye;GO:0061072,biological_process iris morphogenesis;GO:0061303,biological_process cornea development in camera-type eye;GO:0070410,molecular_function co-SMAD binding;GO:0070412,molecular_function R-SMAD binding;GO:0071837,molecular_function HMG box domain binding;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000178,biological_process negative regulation of neural precursor cell proliferation	PAX6; paired box protein 6; K08031	paired box 6 [Source:HGNC Symbol%3BAcc:HGNC:8620]
ENSG00000173786	34.45	39.35	36.31	36.22	35.19	36.19	0.0401154340153619	5.52173825227198	0.565209475457919	0.85997091778897	17:41966740-41977731:+	CNP	31;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0003723,molecular_function RNA binding;GO:0004113,molecular_function 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0007268,biological_process chemical synaptic transmission;GO:0007409,biological_process axonogenesis;GO:0007568,biological_process aging;GO:0008344,biological_process adult locomotory behavior;GO:0009214,biological_process cyclic nucleotide catabolic process;GO:0009636,biological_process response to toxic substance;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0021762,biological_process substantia nigra development;GO:0030551,molecular_function cyclic nucleotide binding;GO:0030900,biological_process forebrain development;GO:0031143,cellular_component pseudopodium;GO:0032496,biological_process response to lipopolysaccharide;GO:0035748,cellular_component myelin sheath abaxonal region;GO:0035749,cellular_component myelin sheath adaxonal region;GO:0042470,cellular_component melanosome;GO:0042995,cellular_component cell projection;GO:0043209,cellular_component myelin sheath;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048709,biological_process oligodendrocyte differentiation;GO:0070062,cellular_component extracellular exosome	NA	2'%2C3'-cyclic nucleotide 3' phosphodiesterase [Source:HGNC Symbol%3BAcc:HGNC:2158]
ENSG00000100124	10.98	10.60	8.54	12.03	9.27	10.86	-0.0863713083508395	3.34645668651096	0.565254387999694	0.85997091778897	22:37830854-37849327:-	ANKRD54	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006913,biological_process nucleocytoplasmic transport;GO:0019887,molecular_function protein kinase regulator activity;GO:0030496,cellular_component midbody;GO:0032403,molecular_function protein complex binding;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045859,biological_process regulation of protein kinase activity;GO:1902531,biological_process regulation of intracellular signal transduction	NA	ankyrin repeat domain 54 [Source:HGNC Symbol%3BAcc:HGNC:25185]
ENSG00000188938	17.42	16.60	17.10	20.44	15.62	18.02	-0.068156722570286	3.88972808243229	0.565386864990201	0.860067053323941	9:93446493-93453592:-	FAM120AOS	NA	NA	family with sequence similarity 120A opposite strand [Source:HGNC Symbol%3BAcc:HGNC:23389]
ENSG00000219435	1.88	0.48	1.47	0.62	1.77	2.46	-0.278622125950256	0.0706706148673531	0.565585669854215	0.860264050961937	11:64300390-64304770:+	CATSPERZ	11;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007140,biological_process male meiosis;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0030317,biological_process sperm motility;GO:0036128,cellular_component CatSper complex;GO:0042995,cellular_component cell projection;GO:0048240,biological_process sperm capacitation;GO:0097228,cellular_component sperm principal piece	NA	catsper channel auxiliary subunit zeta [Source:HGNC Symbol%3BAcc:HGNC:19231]
ENSG00000137947	29.87	25.71	24.53	28.12	29.84	26.11	-0.0536717025819392	4.7079024900327	0.565763798200105	0.860429554895602	1:88852931-88891944:-	GTF2B	23;GO:0001047,molecular_function core promoter binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0016604,cellular_component nuclear body;GO:0017025,molecular_function TBP-class protein binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0050434,biological_process positive regulation of viral transcription;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:0070897,biological_process DNA-templated transcriptional preinitiation complex assembly;GO:0097550,cellular_component transcriptional preinitiation complex;GO:1904798,biological_process positive regulation of core promoter binding	TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB; K03124	general transcription factor IIB [Source:HGNC Symbol%3BAcc:HGNC:4648]
ENSG00000198718	4.63	4.04	4.52	4.30	4.25	4.32	0.0539630916311508	4.54391283460512	0.56586201321172	0.86047349871335	14:44962207-45074431:+	TOGARAM1	10;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0030030,biological_process cell projection organization;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0035082,biological_process axoneme assembly;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:1905515,biological_process non-motile cilium assembly	NA	TOG array regulator of axonemal microtubules 1 [Source:HGNC Symbol%3BAcc:HGNC:19959]
ENSG00000114857	24.70	24.59	26.46	23.96	25.49	24.97	0.0377351937922679	6.79103554219378	0.565934053262486	0.860477633898485	3:42600613-42648741:+	NKTR	10;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0016018,molecular_function cyclosporin A binding;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity	NA	natural killer cell triggering receptor [Source:HGNC Symbol%3BAcc:HGNC:7833]
ENSG00000130270	7.11	7.10	7.13	8.02	7.33	6.90	-0.0470748873272083	4.95321211145453	0.566054447210891	0.860555279023735	19:1782074-1812276:-	ATP8B3	21;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001669,cellular_component acrosomal vesicle;GO:0002080,cellular_component acrosomal membrane;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0007030,biological_process Golgi organization;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding	NA	ATPase phospholipid transporting 8B3 [Source:HGNC Symbol%3BAcc:HGNC:13535]
ENSG00000066777	34.08	32.93	33.44	34.25	33.66	35.84	-0.0344362244923752	7.6193572946533	0.566159312199181	0.860609299819793	8:67173510-67343677:-	ARFGEF1	31;GO:0000139,cellular_component Golgi membrane;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0007030,biological_process Golgi organization;GO:0010256,biological_process endomembrane system organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0017022,molecular_function myosin binding;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0031175,biological_process neuron projection development;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0034260,biological_process negative regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0090284,biological_process positive regulation of protein glycosylation in Golgi;GO:0090303,biological_process positive regulation of wound healing;GO:2000114,biological_process regulation of establishment of cell polarity	NA	ADP ribosylation factor guanine nucleotide exchange factor 1 [Source:HGNC Symbol%3BAcc:HGNC:15772]
ENSG00000165233	27.06	25.41	30.90	27.24	25.72	28.16	0.055660660737133	4.68246672846554	0.566429567438792	0.860713438561895	9:93096217-93113283:+	CARD19	10;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050700,molecular_function CARD domain binding	NA	caspase recruitment domain family member 19 [Source:HGNC Symbol%3BAcc:HGNC:28148]
ENSG00000224877	34.24	38.44	36.09	32.18	37.61	34.87	0.0617648929487713	3.70466851316263	0.566686271593168	0.860713438561895	17:81239238-81241281:+	NDUFAF8	3;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NA	NADH:ubiquinone oxidoreductase complex assembly factor 8 [Source:HGNC Symbol%3BAcc:HGNC:33551]
ENSG00000196659	3.26	3.74	3.39	3.72	3.80	3.56	-0.0889319252985462	2.86308643930214	0.566779711204123	0.860713438561895	2:177548997-177553014:-	TTC30B	9;GO:0005515,molecular_function protein binding;GO:0005929,cellular_component cilium;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip	NA	tetratricopeptide repeat domain 30B [Source:HGNC Symbol%3BAcc:HGNC:26425]
ENSG00000184470	11.04	8.24	9.82	8.42	10.05	9.65	0.0701632731562853	4.33994754225075	0.566829210701838	0.860713438561895	22:19875516-19941992:-	TXNRD2	14;GO:0000305,biological_process response to oxygen radical;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0016668,molecular_function oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor;GO:0034599,biological_process cellular response to oxidative stress;GO:0045454,biological_process cell redox homeostasis;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0098869,biological_process cellular oxidant detoxification	trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]; K00384	thioredoxin reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:18155]
ENSG00000106077	12.55	12.47	13.15	12.24	13.19	14.75	-0.0633737504885976	3.80708198117212	0.566892758491699	0.860713438561895	7:73736093-73738867:-	ABHD11	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity	NA	abhydrolase domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:16407]
ENSG00000177700	318.34	395.57	313.45	303.21	389.40	298.06	0.0618568263729168	6.07967481102858	0.566915942789077	0.860713438561895	11:837355-842545:-	POLR2L	34;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001054,molecular_function RNA polymerase I activity;GO:0001055,molecular_function RNA polymerase II activity;GO:0001056,molecular_function RNA polymerase III activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006356,biological_process regulation of transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008270,molecular_function zinc ion binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0032481,biological_process positive regulation of type I interferon production;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	NA	RNA polymerase II subunit L [Source:HGNC Symbol%3BAcc:HGNC:9199]
ENSG00000169629	1.88	1.57	1.47	1.52	1.57	1.61	0.0815899068385136	3.14560087006882	0.567008659111285	0.860713438561895	2:112370091-112434488:-	RGPD8	6;GO:0000042,biological_process protein targeting to Golgi;GO:0005622,cellular_component intracellular;GO:0005643,cellular_component nuclear pore;GO:0008150,biological_process biological_process;GO:0008536,molecular_function Ran GTPase binding;GO:0046907,biological_process intracellular transport	NA	RANBP2-like and GRIP domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:9849]
ENSG00000108953	672.90	682.49	666.58	692.93	699.18	692.32	-0.032221005054383	9.05598986291919	0.567043144828836	0.860713438561895	17:1344271-1400378:-	YWHAE	58;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000165,biological_process MAPK cascade;GO:0001764,biological_process neuron migration;GO:0003064,biological_process regulation of heart rate by hormone;GO:0003723,molecular_function RNA binding;GO:0005246,molecular_function calcium channel regulator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005871,cellular_component kinesin complex;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006605,biological_process protein targeting;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0021762,biological_process substantia nigra development;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0023026,molecular_function MHC class II protein complex binding;GO:0030424,cellular_component axon;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0034605,biological_process cellular response to heat;GO:0035308,biological_process negative regulation of protein dephosphorylation;GO:0035329,biological_process hippo signaling;GO:0035556,biological_process intracellular signal transduction;GO:0042470,cellular_component melanosome;GO:0042826,molecular_function histone deacetylase binding;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044325,molecular_function ion channel binding;GO:0045296,molecular_function cadherin binding;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0046982,molecular_function protein heterodimerization activity;GO:0050815,molecular_function phosphoserine binding;GO:0051219,molecular_function phosphoprotein binding;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0060306,biological_process regulation of membrane repolarization;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0086013,biological_process membrane repolarization during cardiac muscle cell action potential;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0090724,cellular_component central region of growth cone;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1900034,biological_process regulation of cellular response to heat;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1901016,biological_process regulation of potassium ion transmembrane transporter activity;GO:1901020,biological_process negative regulation of calcium ion transmembrane transporter activity;GO:1902309,biological_process negative regulation of peptidyl-serine dephosphorylation;GO:1905913,biological_process negative regulation of calcium ion export from cell	YWHAE; 14-3-3 protein epsilon; K06630	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [Source:HGNC Symbol%3BAcc:HGNC:12851]
ENSG00000139998	8.51	7.38	6.20	7.44	8.78	7.57	-0.0926084924290408	2.74399411417624	0.567044121355277	0.860713438561895	14:64945813-64972776:-	RAB15	16;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0009306,biological_process protein secretion;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:1903307,biological_process positive regulation of regulated secretory pathway	NA	RAB15%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:20150]
ENSG00000187097	10.11	8.89	8.77	9.14	8.93	11.40	-0.0725428377500951	3.73636197360834	0.5671033843883	0.860713438561895	14:73958009-74019399:-	ENTPD5	17;GO:0004382,molecular_function guanosine-diphosphatase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0008283,biological_process cell proliferation;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016049,biological_process cell growth;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0045134,molecular_function uridine-diphosphatase activity;GO:0045821,biological_process positive regulation of glycolytic process;GO:0046034,biological_process ATP metabolic process;GO:0051084,biological_process 'de novo' posttranslational protein folding;GO:0070062,cellular_component extracellular exosome	ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6]; K01511	ectonucleoside triphosphate diphosphohydrolase 5 [Source:HGNC Symbol%3BAcc:HGNC:3367]
ENSG00000165259	0.75	1.02	0.68	0.83	0.62	0.68	0.179041116808459	0.775080251315592	0.567110596266883	0.860713438561895	X:84317873-84502479:-	HDX	2;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	highly divergent homeobox [Source:HGNC Symbol%3BAcc:HGNC:26411]
ENSG00000136244	6.51	5.54	7.18	7.60	2.80	6.86	0.170768288421249	2.2618315756609	0.567165685002598	0.860713438561895	7:22725883-22732002:+	IL6	132;GO:0001781,biological_process neutrophil apoptotic process;GO:0001878,biological_process response to yeast;GO:0002262,biological_process myeloid cell homeostasis;GO:0002384,biological_process hepatic immune response;GO:0002446,biological_process neutrophil mediated immunity;GO:0002526,biological_process acute inflammatory response;GO:0002548,biological_process monocyte chemotaxis;GO:0002675,biological_process positive regulation of acute inflammatory response;GO:0002690,biological_process positive regulation of leukocyte chemotaxis;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005138,molecular_function interleukin-6 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005896,cellular_component interleukin-6 receptor complex;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006953,biological_process acute-phase response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0006959,biological_process humoral immune response;GO:0007568,biological_process aging;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009408,biological_process response to heat;GO:0009409,biological_process response to cold;GO:0009611,biological_process response to wounding;GO:0009612,biological_process response to mechanical stimulus;GO:0009617,biological_process response to bacterium;GO:0009897,cellular_component external side of plasma membrane;GO:0010574,biological_process regulation of vascular endothelial growth factor production;GO:0010628,biological_process positive regulation of gene expression;GO:0010888,biological_process negative regulation of lipid storage;GO:0010976,biological_process positive regulation of neuron projection development;GO:0010996,biological_process response to auditory stimulus;GO:0014070,biological_process response to organic cyclic compound;GO:0016049,biological_process cell growth;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030168,biological_process platelet activation;GO:0031000,biological_process response to caffeine;GO:0031018,biological_process endocrine pancreas development;GO:0031175,biological_process neuron projection development;GO:0031294,biological_process lymphocyte costimulation;GO:0031667,biological_process response to nutrient levels;GO:0031669,biological_process cellular response to nutrient levels;GO:0032494,biological_process response to peptidoglycan;GO:0032496,biological_process response to lipopolysaccharide;GO:0032722,biological_process positive regulation of chemokine production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032868,biological_process response to insulin;GO:0032966,biological_process negative regulation of collagen biosynthetic process;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0034097,biological_process response to cytokine;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0042060,biological_process wound healing;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042110,biological_process T cell activation;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042593,biological_process glucose homeostasis;GO:0042832,biological_process defense response to protozoan;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043200,biological_process response to amino acid;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045079,biological_process negative regulation of chemokine biosynthetic process;GO:0045188,biological_process regulation of circadian sleep/wake cycle, non-REM sleep;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045454,biological_process cell redox homeostasis;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045630,biological_process positive regulation of T-helper 2 cell differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045721,biological_process negative regulation of gluconeogenesis;GO:0045727,biological_process positive regulation of translation;GO:0045740,biological_process positive regulation of DNA replication;GO:0045765,biological_process regulation of angiogenesis;GO:0045779,biological_process negative regulation of bone resorption;GO:0045837,biological_process negative regulation of membrane potential;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0046677,biological_process response to antibiotic;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046849,biological_process bone remodeling;GO:0046888,biological_process negative regulation of hormone secretion;GO:0048635,biological_process negative regulation of muscle organ development;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050710,biological_process negative regulation of cytokine secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0050871,biological_process positive regulation of B cell activation;GO:0051024,biological_process positive regulation of immunoglobulin secretion;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051384,biological_process response to glucocorticoid;GO:0051592,biological_process response to calcium ion;GO:0051602,biological_process response to electrical stimulus;GO:0051607,biological_process defense response to virus;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051971,biological_process positive regulation of transmission of nerve impulse;GO:0060445,biological_process branching involved in salivary gland morphogenesis;GO:0060664,biological_process epithelial cell proliferation involved in salivary gland morphogenesis;GO:0070091,biological_process glucagon secretion;GO:0070102,biological_process interleukin-6-mediated signaling pathway;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0071864,biological_process positive regulation of cell proliferation in bone marrow;GO:0072540,biological_process T-helper 17 cell lineage commitment;GO:1901215,biological_process negative regulation of neuron death;GO:1990646,biological_process cellular response to prolactin;GO:2000366,biological_process positive regulation of STAT protein import into nucleus;GO:2000553,biological_process positive regulation of T-helper 2 cell cytokine production;GO:2000660,biological_process negative regulation of interleukin-1-mediated signaling pathway;GO:2000676,biological_process positive regulation of type B pancreatic cell apoptotic process	IL6; interleukin 6; K05405	interleukin 6 [Source:HGNC Symbol%3BAcc:HGNC:6018]
ENSG00000048649	13.33	13.55	13.81	13.18	13.21	13.60	0.0363764862267333	5.8657340677108	0.567234417000626	0.860713438561895	11:77659995-77821017:-	RSF1	18;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016584,biological_process nucleosome positioning;GO:0031213,cellular_component RSF complex;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0042393,molecular_function histone binding;GO:0043392,biological_process negative regulation of DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0050434,biological_process positive regulation of viral transcription	NA	remodeling and spacing factor 1 [Source:HGNC Symbol%3BAcc:HGNC:18118]
ENSG00000116819	1.65	2.09	2.22	2.09	1.77	1.59	0.134689818889721	1.4123321159097	0.567281317228476	0.860713438561895	1:35573369-35595328:+	TFAP2E	15;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0042127,biological_process regulation of cell proliferation;GO:0042803,molecular_function protein homodimerization activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048856,biological_process anatomical structure development	NA	transcription factor AP-2 epsilon [Source:HGNC Symbol%3BAcc:HGNC:30774]
ENSG00000167470	22.21	18.89	21.12	19.88	19.99	20.96	0.0502109949415437	4.98489605412816	0.567285180163123	0.860713438561895	19:1248552-1259140:+	MIDN	9;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0019900,molecular_function kinase binding;GO:0033132,biological_process negative regulation of glucokinase activity;GO:0046676,biological_process negative regulation of insulin secretion	NA	midnolin [Source:HGNC Symbol%3BAcc:HGNC:16298]
ENSG00000170684	0.84	0.60	0.88	0.95	1.01	0.79	-0.19917203761298	0.451621982663126	0.56737369509857	0.860713438561895	19:45071499-45076588:-	ZNF296	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007283,biological_process spermatogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 296 [Source:HGNC Symbol%3BAcc:HGNC:15981]
ENSG00000123610	10.62	11.85	10.98	11.53	14.42	9.90	-0.089932103126386	3.28210088078034	0.567420929996768	0.860713438561895	2:151357591-151380048:+	TNFAIP6	14;GO:0005515,molecular_function protein binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0030335,biological_process positive regulation of cell migration;GO:0030728,biological_process ovulation;GO:0043312,biological_process neutrophil degranulation;GO:0050728,biological_process negative regulation of inflammatory response;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	TNF alpha induced protein 6 [Source:HGNC Symbol%3BAcc:HGNC:11898]
ENSG00000117174	27.25	23.99	27.77	26.02	23.40	27.68	0.0508947993437553	5.20652509771592	0.567475935002864	0.860713438561895	1:85649422-85708433:-	ZNHIT6	12;GO:0000492,biological_process box C/D snoRNP assembly;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0005515,molecular_function protein binding;GO:0019899,molecular_function enzyme binding;GO:0042254,biological_process ribosome biogenesis;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0048254,biological_process snoRNA localization;GO:0051117,molecular_function ATPase binding;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome;GO:0070761,cellular_component pre-snoRNP complex	NA	zinc finger HIT-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:26089]
ENSG00000143793	28.02	24.59	28.08	27.90	27.20	29.41	-0.0489688269475608	4.45580903213107	0.56786223402927	0.860713961345349	1:228100725-228105411:-	C1orf35	6;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	chromosome 1 open reading frame 35 [Source:HGNC Symbol%3BAcc:HGNC:19032]
ENSG00000155329	9.61	13.27	8.36	10.08	11.49	11.93	-0.108157181796602	2.96206204475197	0.5678628910708	0.860713961345349	5:132996984-133026604:-	ZCCHC10	4;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 10 [Source:HGNC Symbol%3BAcc:HGNC:25954]
ENSG00000160209	65.39	70.54	66.98	67.72	65.46	66.17	0.0358643031355048	6.94338172510608	0.567876056064266	0.860713961345349	21:43719093-43762307:+	PDXK	26;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008478,molecular_function pyridoxal kinase activity;GO:0009443,biological_process pyridoxal 5'-phosphate salvage;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030955,molecular_function potassium ion binding;GO:0031402,molecular_function sodium ion binding;GO:0031403,molecular_function lithium ion binding;GO:0034774,cellular_component secretory granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0042816,biological_process vitamin B6 metabolic process;GO:0042823,biological_process pyridoxal phosphate biosynthetic process;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]; K00868	pyridoxal kinase [Source:HGNC Symbol%3BAcc:HGNC:8819]
ENSG00000143061	16.31	18.42	16.67	16.45	19.45	17.53	-0.046677548009579	5.99460260029069	0.567890960276266	0.860713961345349	1:116574398-116667755:-	IGSF3	7;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032808,biological_process lacrimal gland development	NA	immunoglobulin superfamily member 3 [Source:HGNC Symbol%3BAcc:HGNC:5950]
ENSG00000238083	1.12	1.54	0.89	1.19	1.25	1.41	-0.12302573183172	2.67678966220609	0.56795468437633	0.860713961345349	17:46511510-46555650:+	LRRC37A2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	leucine rich repeat containing 37 member A2 [Source:HGNC Symbol%3BAcc:HGNC:32404]
ENSG00000184047	21.16	23.23	22.17	22.01	21.57	21.29	0.0444371526539333	4.78765246521045	0.567961269233771	0.860713961345349	12:122207661-122227534:-	DIABLO	17;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035631,cellular_component CD40 receptor complex;GO:0043065,biological_process positive regulation of apoptotic process;GO:0051402,biological_process neuron apoptotic process;GO:0097193,biological_process intrinsic apoptotic signaling pathway	DIABLO, SMAC; diablo; K10522	diablo IAP-binding mitochondrial protein [Source:HGNC Symbol%3BAcc:HGNC:21528]
ENSG00000115170	25.39	22.66	26.80	26.87	21.66	24.31	0.054710523300638	5.24101960350282	0.567994660251165	0.860713961345349	2:157736443-157875862:-	ACVR1	69;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0001569,biological_process patterning of blood vessels;GO:0001701,biological_process in utero embryonic development;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001707,biological_process mesoderm formation;GO:0001755,biological_process neural crest cell migration;GO:0002526,biological_process acute inflammatory response;GO:0003143,biological_process embryonic heart tube morphogenesis;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003183,biological_process mitral valve morphogenesis;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003274,biological_process endocardial cushion fusion;GO:0003289,biological_process atrial septum primum morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005025,molecular_function transforming growth factor beta receptor activity, type I;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007281,biological_process germ cell development;GO:0007368,biological_process determination of left/right symmetry;GO:0007369,biological_process gastrulation;GO:0007498,biological_process mesoderm development;GO:0007507,biological_process heart development;GO:0009968,biological_process negative regulation of signal transduction;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016361,molecular_function activin receptor activity, type I;GO:0016740,molecular_function transferase activity;GO:0017046,molecular_function peptide hormone binding;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019838,molecular_function growth factor binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030278,biological_process regulation of ossification;GO:0030335,biological_process positive regulation of cell migration;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0032924,biological_process activin receptor signaling pathway;GO:0032926,biological_process negative regulation of activin receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0045177,cellular_component apical part of cell;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0048179,cellular_component activin receptor complex;GO:0048185,molecular_function activin binding;GO:0050431,molecular_function transforming growth factor beta binding;GO:0051145,biological_process smooth muscle cell differentiation;GO:0060037,biological_process pharyngeal system development;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060923,biological_process cardiac muscle cell fate commitment;GO:0061312,biological_process BMP signaling pathway involved in heart development;GO:0061445,biological_process endocardial cushion cell fate commitment;GO:0071773,biological_process cellular response to BMP stimulus;GO:1905007,biological_process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:2000017,biological_process positive regulation of determination of dorsal identity;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	ACVR1, ALK2; activin receptor type-1 [EC:2.7.11.30]; K04675	activin A receptor type 1 [Source:HGNC Symbol%3BAcc:HGNC:171]
ENSG00000164236	3.62	3.51	3.49	3.89	4.51	3.12	-0.0991618308612619	2.58029620556989	0.568357653342382	0.860713961345349	5:10564329-10657816:+	ANKRD33B	NA	NA	ankyrin repeat domain 33B [Source:HGNC Symbol%3BAcc:HGNC:35240]
ENSG00000196110	3.45	3.92	4.09	3.50	4.25	4.49	-0.0893093203317843	2.95684912234587	0.568358839090341	0.860713961345349	19:9294274-9309838:-	ZNF699	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 699 [Source:HGNC Symbol%3BAcc:HGNC:24750]
ENSG00000077152	48.76	51.74	47.32	53.59	55.31	45.57	-0.0532266955317936	4.9024251191539	0.568455624591431	0.860713961345349	1:202331656-202341980:-	UBE2T	25;GO:0000166,molecular_function nucleotide binding;GO:0003682,molecular_function chromatin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035519,biological_process protein K29-linked ubiquitination;GO:0036297,biological_process interstrand cross-link repair;GO:0044314,biological_process protein K27-linked ubiquitination;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0085020,biological_process protein K6-linked ubiquitination	UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]; K13960	ubiquitin conjugating enzyme E2 T [Source:HGNC Symbol%3BAcc:HGNC:25009]
ENSG00000215183	41.66	40.79	40.42	44.71	46.01	38.45	-0.0578426949871965	4.14375792164886	0.568497288962083	0.860713961345349	9:35752989-35756613:-	MSMP	5;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process	NA	microseminoprotein%2C prostate associated [Source:HGNC Symbol%3BAcc:HGNC:29663]
ENSG00000145337	41.10	31.58	38.52	33.28	33.93	39.68	0.0779457245175332	3.66117950644076	0.568510616786859	0.860713961345349	4:88520984-88523813:-	PYURF	6;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0009893,biological_process positive regulation of metabolic process	NA	PIGY upstream reading frame [Source:HGNC Symbol%3BAcc:HGNC:44317]
ENSG00000121350	10.59	10.08	11.47	11.57	10.68	11.47	-0.0531929212054881	4.08362882972164	0.568518924671316	0.860713961345349	12:21437614-21471252:+	PYROXD1	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016491,molecular_function oxidoreductase activity;GO:0030017,cellular_component sarcomere;GO:0034599,biological_process cellular response to oxidative stress;GO:0055114,biological_process oxidation-reduction process	NA	pyridine nucleotide-disulphide oxidoreductase domain 1 [Source:HGNC Symbol%3BAcc:HGNC:26162]
ENSG00000119771	3.71	4.33	4.85	4.93	4.19	4.58	-0.0784371714470491	3.56010059980774	0.56860902748246	0.860713961345349	2:23385216-23708611:+	KLHL29	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	kelch like family member 29 [Source:HGNC Symbol%3BAcc:HGNC:29404]
ENSG00000067113	9.61	10.44	10.52	9.15	12.58	10.89	-0.0834493268304951	3.42721799335777	0.568710638400653	0.860713961345349	5:55424853-55535050:-	PLPP1	21;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008354,biological_process germ cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042392,molecular_function sphingosine-1-phosphate phosphatase activity;GO:0042577,molecular_function lipid phosphatase activity;GO:0046839,biological_process phospholipid dephosphorylation;GO:0070062,cellular_component extracellular exosome	PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]; K01080	phospholipid phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:9228]
ENSG00000106415	6.33	6.36	5.90	5.82	6.71	5.26	0.0752706799505915	3.37108951765626	0.56880360379337	0.860713961345349	7:7968793-8094272:+	GLCCI1	NA	NA	glucocorticoid induced 1 [Source:HGNC Symbol%3BAcc:HGNC:18713]
ENSG00000138758	56.33	56.59	57.26	52.78	57.42	57.05	0.0367604817862615	6.28493122037046	0.568819613827209	0.860713961345349	4:76949702-77040384:+	SEPT11	15;GO:0000166,molecular_function nucleotide binding;GO:0001725,cellular_component stress fiber;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0045202,cellular_component synapse;GO:0051291,biological_process protein heterooligomerization;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome	SEPT6_8_11; septin 6/8/11; K16939	septin 11 [Source:HGNC Symbol%3BAcc:HGNC:25589]
ENSG00000177595	7.04	6.93	7.31	7.19	6.54	8.64	-0.0617492164776884	4.34146577040662	0.568871374299688	0.860713961345349	11:799178-809753:-	PIDD1	19;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001235,biological_process positive regulation of apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	LRDD, PIDD; leucine-rich repeats and death domain-containing protein; K10130	p53-induced death domain protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16491]
ENSG00000127947	91.69	85.92	92.71	94.53	86.95	98.42	-0.037899557479212	7.77029171559078	0.568964796486337	0.860713961345349	7:77537274-77640071:+	PTPN12	22;GO:0002102,cellular_component podosome;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006470,biological_process protein dephosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030054,cellular_component cell junction;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042058,biological_process regulation of epidermal growth factor receptor signaling pathway;GO:0042246,biological_process tissue regeneration;GO:0042995,cellular_component cell projection;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:2000587,biological_process negative regulation of platelet-derived growth factor receptor-beta signaling pathway	NA	protein tyrosine phosphatase%2C non-receptor type 12 [Source:HGNC Symbol%3BAcc:HGNC:9645]
ENSG00000138079	9.96	10.62	8.74	8.54	10.12	9.68	0.055386031039905	4.51996068328695	0.568973821251699	0.860713961345349	2:44275457-44321494:+	SLC3A1	22;GO:0003333,biological_process amino acid transmembrane transport;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005774,cellular_component vacuolar membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015174,molecular_function basic amino acid transmembrane transporter activity;GO:0015184,molecular_function L-cystine transmembrane transporter activity;GO:0015802,biological_process basic amino acid transport;GO:0015811,biological_process L-cystine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031526,cellular_component brush border membrane;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome;GO:1990822,biological_process basic amino acid transmembrane transport	SLC3A1, RBAT; solute carrier family 3 (neutral and basic amino acid transporter), member 1; K14210	solute carrier family 3 member 1 [Source:HGNC Symbol%3BAcc:HGNC:11025]
ENSG00000080293	0.96	1.63	1.71	1.28	1.76	1.82	-0.182745408567975	1.25225736517284	0.569001425294716	0.860713961345349	2:119439842-119525301:-	SCTR	14;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007586,biological_process digestion;GO:0007588,biological_process excretion;GO:0015055,molecular_function secretin receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	SCTR; secretin receptor; K04588	secretin receptor [Source:HGNC Symbol%3BAcc:HGNC:10608]
ENSG00000196584	6.47	7.39	6.83	7.84	6.05	8.37	-0.103234288326348	2.62497064401226	0.569070635381275	0.860713961345349	7:152644778-152676165:-	XRCC2	41;GO:0000150,molecular_function recombinase activity;GO:0000278,biological_process mitotic cell cycle;GO:0000400,molecular_function four-way junction DNA binding;GO:0000707,biological_process meiotic DNA recombinase assembly;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0001701,biological_process in utero embryonic development;GO:0001756,biological_process somitogenesis;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006312,biological_process mitotic recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007098,biological_process centrosome cycle;GO:0007131,biological_process reciprocal meiotic recombination;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0010165,biological_process response to X-ray;GO:0010212,biological_process response to ionizing radiation;GO:0010332,biological_process response to gamma radiation;GO:0022008,biological_process neurogenesis;GO:0033063,cellular_component Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0035264,biological_process multicellular organism growth;GO:0042148,biological_process strand invasion;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0050769,biological_process positive regulation of neurogenesis;GO:0051321,biological_process meiotic cell cycle;GO:2000269,biological_process regulation of fibroblast apoptotic process	XRCC2; DNA-repair protein XRCC2; K10879	X-ray repair cross complementing 2 [Source:HGNC Symbol%3BAcc:HGNC:12829]
ENSG00000100138	158.12	150.96	133.29	161.66	147.72	150.26	-0.0441420905604567	5.92169720376139	0.569071093270062	0.860713961345349	22:41673929-41690504:-	SNU13	28;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000470,biological_process maturation of LSU-rRNA;GO:0000492,biological_process box C/D snoRNP assembly;GO:0001651,cellular_component dense fibrillar component;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0006397,biological_process mRNA processing;GO:0007338,biological_process single fertilization;GO:0008380,biological_process RNA splicing;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030621,molecular_function U4 snRNA binding;GO:0030622,molecular_function U4atac snRNA binding;GO:0031428,cellular_component box C/D snoRNP complex;GO:0032040,cellular_component small-subunit processome;GO:0034511,molecular_function U3 snoRNA binding;GO:0034512,molecular_function box C/D snoRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0043234,cellular_component protein complex;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0051117,molecular_function ATPase binding;GO:0071011,cellular_component precatalytic spliceosome	NA	small nuclear ribonucleoprotein 13 [Source:HGNC Symbol%3BAcc:HGNC:7819]
ENSG00000166780	13.74	11.42	15.72	13.22	14.03	12.04	0.0802410726480743	3.68267702807872	0.569203871935565	0.860809900382086	16:15434294-15625028:+	C16orf45	4;GO:0005515,molecular_function protein binding;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0015630,cellular_component microtubule cytoskeleton;GO:0021822,biological_process negative regulation of cell motility involved in cerebral cortex radial glia guided migration	NA	chromosome 16 open reading frame 45 [Source:HGNC Symbol%3BAcc:HGNC:19213]
ENSG00000182093	41.95	43.84	39.54	44.68	47.93	38.44	-0.0538041787362375	4.98685490427436	0.569320960415973	0.860861097607532	21:39380243-39428528:+	WRB	6;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0071816,biological_process tail-anchored membrane protein insertion into ER membrane	NA	tryptophan rich basic protein [Source:HGNC Symbol%3BAcc:HGNC:12790]
ENSG00000255561	0.66	1.14	0.88	1.28	0.75	0.22	0.254342406065109	0.765392224886196	0.569413170267454	0.860861097607532	11:111874055-111881243:-	FDXACB1	4;GO:0004826,molecular_function phenylalanine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0006432,biological_process phenylalanyl-tRNA aminoacylation;GO:0009328,cellular_component phenylalanine-tRNA ligase complex	NA	ferredoxin-fold anticodon binding domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25110]
ENSG00000186654	3.20	2.42	2.32	2.07	3.26	1.95	0.150001566574453	1.78997818763491	0.569445780428216	0.860861097607532	22:44668546-44737681:+	PRR5	9;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0031295,biological_process T cell costimulation;GO:0031932,cellular_component TORC2 complex;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038203,biological_process TORC2 signaling;GO:0048015,biological_process phosphatidylinositol-mediated signaling	NA	proline rich 5 [Source:HGNC Symbol%3BAcc:HGNC:31682]
ENSG00000163485	30.64	35.70	34.40	30.48	39.20	27.17	0.0673759372686946	5.06232520861666	0.569570682365362	0.860945065781933	1:203090653-203167405:+	ADORA1	79;GO:0000186,biological_process activation of MAPKK activity;GO:0001609,molecular_function G-protein coupled adenosine receptor activity;GO:0001659,biological_process temperature homeostasis;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001666,biological_process response to hypoxia;GO:0001883,molecular_function purine nucleoside binding;GO:0001973,biological_process adenosine receptor signaling pathway;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0002674,biological_process negative regulation of acute inflammatory response;GO:0002686,biological_process negative regulation of leukocyte migration;GO:0002793,biological_process positive regulation of peptide secretion;GO:0003093,biological_process regulation of glomerular filtration;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006612,biological_process protein targeting to membrane;GO:0006909,biological_process phagocytosis;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0012505,cellular_component endomembrane system;GO:0014050,biological_process negative regulation of glutamate secretion;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016323,cellular_component basolateral plasma membrane;GO:0030425,cellular_component dendrite;GO:0030673,cellular_component axolemma;GO:0031072,molecular_function heat shock protein binding;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0032229,biological_process negative regulation of synaptic transmission, GABAergic;GO:0032244,biological_process positive regulation of nucleoside transport;GO:0032279,cellular_component asymmetric synapse;GO:0032795,molecular_function heterotrimeric G-protein binding;GO:0032900,biological_process negative regulation of neurotrophin production;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0035814,biological_process negative regulation of renal sodium excretion;GO:0042321,biological_process negative regulation of circadian sleep/wake cycle, sleep;GO:0042323,biological_process negative regulation of circadian sleep/wake cycle, non-REM sleep;GO:0042734,cellular_component presynaptic membrane;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043195,cellular_component terminal bouton;GO:0043197,cellular_component dendritic spine;GO:0043268,biological_process positive regulation of potassium ion transport;GO:0044297,cellular_component cell body;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045741,biological_process positive regulation of epidermal growth factor-activated receptor activity;GO:0045776,biological_process negative regulation of blood pressure;GO:0045777,biological_process positive regulation of blood pressure;GO:0045822,biological_process negative regulation of heart contraction;GO:0046888,biological_process negative regulation of hormone secretion;GO:0046982,molecular_function protein heterodimerization activity;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048786,cellular_component presynaptic active zone;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050890,biological_process cognition;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain;GO:0050995,biological_process negative regulation of lipid catabolic process;GO:0051930,biological_process regulation of sensory perception of pain;GO:0051967,biological_process negative regulation of synaptic transmission, glutamatergic;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0055118,biological_process negative regulation of cardiac muscle contraction;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060087,biological_process relaxation of vascular smooth muscle;GO:0070256,biological_process negative regulation of mucus secretion;GO:0097190,biological_process apoptotic signaling pathway;GO:0097756,biological_process negative regulation of blood vessel diameter;GO:1900453,biological_process negative regulation of long term synaptic depression	ADORA1; adenosine receptor A1; K04265	adenosine A1 receptor [Source:HGNC Symbol%3BAcc:HGNC:262]
ENSG00000009844	46.16	48.46	47.79	45.61	51.14	51.00	-0.043107205258678	5.48254315867014	0.569652623808242	0.860964083688264	6:142147161-142224689:+	VTA1	19;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008022,molecular_function protein C-terminus binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0036258,biological_process multivesicular body assembly;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046755,biological_process viral budding;GO:0070062,cellular_component extracellular exosome;GO:0071985,biological_process multivesicular body sorting pathway;GO:1904903,biological_process ESCRT III complex disassembly	VTA1, LIP5; vacuolar protein sorting-associated protein VTA1; K12199	vesicle trafficking 1 [Source:HGNC Symbol%3BAcc:HGNC:20954]
ENSG00000062194	35.78	33.07	32.43	35.39	34.38	35.21	-0.0384611253100017	5.69424168289761	0.569749888960745	0.861006254159937	5:57173947-57264679:+	GPBP1	11;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	GC-rich promoter binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29520]
ENSG00000182552	16.65	16.10	14.49	13.94	15.06	16.08	0.0761281818554325	3.14239197470598	0.569843477987521	0.861042859678526	4:183639634-183659225:-	RWDD4	NA	NA	RWD domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:23750]
ENSG00000137218	4.47	4.69	5.66	4.93	5.29	5.63	-0.0840744440085218	3.01601404980943	0.569958462823358	0.861086036747458	6:41770175-41786542:-	FRS3	12;GO:0000165,biological_process MAPK cascade;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005104,molecular_function fibroblast growth factor receptor binding;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0042802,molecular_function identical protein binding;GO:0043547,biological_process positive regulation of GTPase activity	GUCA1; guanylate cyclase activator 1; K08328	fibroblast growth factor receptor substrate 3 [Source:HGNC Symbol%3BAcc:HGNC:16970]
ENSG00000145476	11.84	9.59	11.59	10.51	11.08	10.45	0.0661565413420636	4.11160853924193	0.570010792230231	0.861086036747458	4:186191519-186213456:+	CYP4V2	17;GO:0001523,biological_process retinoid metabolic process;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0007601,biological_process visual perception;GO:0010430,biological_process fatty acid omega-oxidation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016125,biological_process sterol metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037,molecular_function heme binding;GO:0046872,molecular_function metal ion binding;GO:0050896,biological_process response to stimulus;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome P450 family 4 subfamily V member 2 [Source:HGNC Symbol%3BAcc:HGNC:23198]
ENSG00000188010	61.54	74.33	62.63	71.37	64.98	70.93	-0.0600389017952689	4.53845680239628	0.570275355037072	0.861276178222532	2:38875961-38929072:+	MORN2	6;GO:0001669,cellular_component acrosomal vesicle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle	NA	MORN repeat containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30166]
ENSG00000185158	3.72	2.94	4.24	3.47	3.30	3.66	0.0861598817638894	3.57216044569164	0.57027542969556	0.861276178222532	17:32007871-32053504:+	LRRC37B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	leucine rich repeat containing 37B [Source:HGNC Symbol%3BAcc:HGNC:29070]
ENSG00000183337	10.30	10.51	11.53	10.67	10.47	10.60	0.0397180864841137	5.84793632793712	0.570482475006002	0.861423041639349	X:40049814-40177329:-	BCOR	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000415,biological_process negative regulation of histone H3-K36 methylation;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0016569,biological_process covalent chromatin modification;GO:0030502,biological_process negative regulation of bone mineralization;GO:0031072,molecular_function heat shock protein binding;GO:0031519,cellular_component PcG protein complex;GO:0035518,biological_process histone H2A monoubiquitination;GO:0042476,biological_process odontogenesis;GO:0042826,molecular_function histone deacetylase binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051572,biological_process negative regulation of histone H3-K4 methylation;GO:0060021,biological_process palate development;GO:0065001,biological_process specification of axis polarity;GO:0070171,biological_process negative regulation of tooth mineralization	NA	BCL6 corepressor [Source:HGNC Symbol%3BAcc:HGNC:20893]
ENSG00000158290	28.76	30.08	27.32	26.91	28.01	29.59	0.0374930385130529	6.31946608772122	0.570532292300658	0.861423041639349	X:120524608-120575794:-	CUL4B	33;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0010498,biological_process proteasomal protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0031175,biological_process neuron projection development;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031465,cellular_component Cul4B-RING E3 ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0035518,biological_process histone H2A monoubiquitination;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070914,biological_process UV-damage excision repair;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle	CUL4; cullin 4; K10609	cullin 4B [Source:HGNC Symbol%3BAcc:HGNC:2555]
ENSG00000182117	322.97	377.28	330.06	328.34	331.81	347.20	0.0398534958746084	6.02921924682829	0.570612822771174	0.861423041639349	15:34341712-34343177:-	NOP10	24;GO:0000454,biological_process snoRNA guided rRNA pseudouridine synthesis;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0006364,biological_process rRNA processing;GO:0007004,biological_process telomere maintenance via telomerase;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031118,biological_process rRNA pseudouridine synthesis;GO:0031120,biological_process snRNA pseudouridine synthesis;GO:0031429,cellular_component box H/ACA snoRNP complex;GO:0034513,molecular_function box H/ACA snoRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0070034,molecular_function telomerase RNA binding;GO:0072589,cellular_component box H/ACA scaRNP complex;GO:0090661,cellular_component box H/ACA telomerase RNP complex;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NOP10, NOLA3; H/ACA ribonucleoprotein complex subunit 3; K11130	NOP10 ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:14378]
ENSG00000163126	2.55	1.98	1.69	2.70	1.99	2.38	-0.165665302437169	1.1312792241968	0.57070899345302	0.861423041639349	2:96824525-96857934:-	ANKRD23	8;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0009612,biological_process response to mechanical stimulus;GO:0014704,cellular_component intercalated disc;GO:0015629,cellular_component actin cytoskeleton;GO:0030016,cellular_component myofibril;GO:0031432,molecular_function titin binding	NA	ankyrin repeat domain 23 [Source:HGNC Symbol%3BAcc:HGNC:24470]
ENSG00000163075	1.37	1.53	1.20	1.35	1.31	1.15	0.106362265745965	2.00232888250196	0.570752564623762	0.861423041639349	2:119544431-119662251:+	CFAP221	11;GO:0003341,biological_process cilium movement;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0008285,biological_process negative regulation of cell proliferation;GO:0030030,biological_process cell projection organization;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0060271,biological_process cilium morphogenesis	NA	cilia and flagella associated protein 221 [Source:HGNC Symbol%3BAcc:HGNC:33720]
ENSG00000173451	7.81	6.09	6.89	6.13	6.41	7.13	0.101794169327087	2.42381119535784	0.571018052680922	0.861423041639349	12:71663008-71680639:+	THAP2	4;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005730,cellular_component nucleolus;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20854]
ENSG00000164307	13.85	12.35	14.26	13.36	13.30	13.00	0.0462835079967883	5.29633642519065	0.571154690350373	0.861423041639349	5:96760809-96808100:-	ERAP1	39;GO:0001525,biological_process angiogenesis;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0004175,molecular_function endopeptidase activity;GO:0004177,molecular_function aminopeptidase activity;GO:0005138,molecular_function interleukin-6 receptor binding;GO:0005151,molecular_function interleukin-1, Type II receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008217,biological_process regulation of blood pressure;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009617,biological_process response to bacterium;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019885,biological_process antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0045088,biological_process regulation of innate immune response;GO:0045444,biological_process fat cell differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome	NA	endoplasmic reticulum aminopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:18173]
ENSG00000148925	45.57	43.04	41.31	40.91	44.82	41.74	0.0398762828291034	6.05923566243073	0.571181357621009	0.861423041639349	11:13388000-13463297:-	BTBD10	6;GO:0001650,cellular_component fibrillar center;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0042327,biological_process positive regulation of phosphorylation;GO:0044342,biological_process type B pancreatic cell proliferation;GO:1901215,biological_process negative regulation of neuron death	NA	BTB domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:21445]
ENSG00000187240	5.13	5.17	4.91	4.73	5.27	4.93	0.0382448388639584	6.0269050823186	0.57120697525534	0.861423041639349	11:103109430-103479863:+	DYNC2H1	43;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007018,biological_process microtubule-based movement;GO:0007030,biological_process Golgi organization;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008105,biological_process asymmetric protein localization;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0016020,cellular_component membrane;GO:0016485,biological_process protein processing;GO:0016887,molecular_function ATPase activity;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0030030,biological_process cell projection organization;GO:0030182,biological_process neuron differentiation;GO:0030286,cellular_component dynein complex;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030900,biological_process forebrain development;GO:0031514,cellular_component motile cilium;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0045177,cellular_component apical part of cell;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0060976,biological_process coronary vasculature development;GO:0070062,cellular_component extracellular exosome;GO:0097542,cellular_component ciliary tip;GO:1905515,biological_process non-motile cilium assembly	DYNC2H, DNCH2; dynein heavy chain 2, cytosolic; K10414	dynein cytoplasmic 2 heavy chain 1 [Source:HGNC Symbol%3BAcc:HGNC:2962]
ENSG00000148143	7.79	8.14	7.30	7.76	7.38	7.63	0.0373864026129848	5.90305410192599	0.5712915140715	0.861423041639349	9:106863096-107013634:+	ZNF462	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043392,biological_process negative regulation of DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 462 [Source:HGNC Symbol%3BAcc:HGNC:21684]
ENSG00000185864	2.52	2.27	2.37	2.93	1.56	2.21	0.10957242849224	3.15617321682033	0.571382044666945	0.861423041639349	16:21834568-21880827:-	NPIPB4	3;GO:0005654,cellular_component nucleoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear pore complex interacting protein family member B4 [Source:HGNC Symbol%3BAcc:HGNC:41985]
ENSG00000163281	18.61	16.15	20.81	19.33	17.09	22.42	-0.0657024739958047	4.18471536279976	0.571390701030476	0.861423041639349	4:44682199-44726595:-	GNPDA2	9;GO:0004342,molecular_function glucosamine-6-phosphate deaminase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006043,biological_process glucosamine catabolic process;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0016787,molecular_function hydrolase activity	nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]; K02564	glucosamine-6-phosphate deaminase 2 [Source:HGNC Symbol%3BAcc:HGNC:21526]
ENSG00000146858	10.28	7.75	13.66	12.73	9.86	11.80	-0.0948371239070299	3.34407396878215	0.571391856617186	0.861423041639349	7:139025705-139036029:-	ZC3HAV1L	2;GO:0005829,cellular_component cytosol;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing%2C antiviral 1 like [Source:HGNC Symbol%3BAcc:HGNC:22423]
ENSG00000168916	26.94	28.25	27.92	25.68	29.33	26.52	0.0390676756660704	6.96201008081653	0.571394797126455	0.861423041639349	5:124636912-124748807:-	ZNF608	2;GO:0003676,molecular_function nucleic acid binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 608 [Source:HGNC Symbol%3BAcc:HGNC:29238]
ENSG00000120327	0.44	0.84	0.86	0.59	0.38	0.88	0.190366709855074	0.795778610334277	0.571489139019074	0.861423041639349	5:141222931-141227759:+	PCDHB14	11;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007268,biological_process chemical synaptic transmission;GO:0007416,biological_process synapse assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NA	protocadherin beta 14 [Source:HGNC Symbol%3BAcc:HGNC:8685]
ENSG00000065615	17.39	20.63	17.61	15.40	19.20	19.14	0.0554866795254057	4.85261947775866	0.571507621685545	0.861423041639349	6:83859642-83967424:+	CYB5R4	18;GO:0003032,biological_process detection of oxygen;GO:0004128,molecular_function cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006801,biological_process superoxide metabolic process;GO:0015701,biological_process bicarbonate transport;GO:0016174,molecular_function NAD(P)H oxidase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016653,molecular_function oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor;GO:0020037,molecular_function heme binding;GO:0030073,biological_process insulin secretion;GO:0042593,biological_process glucose homeostasis;GO:0046677,biological_process response to antibiotic;GO:0046872,molecular_function metal ion binding;GO:0048468,biological_process cell development;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome b5 reductase 4 [Source:HGNC Symbol%3BAcc:HGNC:20147]
ENSG00000183060	3.31	3.51	2.75	3.61	2.68	2.63	0.106734708970414	2.22208112806191	0.571601835249373	0.861423041639349	15:99715696-99733561:-	LYSMD4	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	LysM domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:26571]
ENSG00000155592	2.91	3.45	3.24	3.16	3.52	3.45	-0.0761541015722844	3.27945719720698	0.571621815353526	0.861423041639349	16:25236000-25257931:-	ZKSCAN2	13;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger with KRAB and SCAN domains 2 [Source:HGNC Symbol%3BAcc:HGNC:25677]
ENSG00000172716	18.71	19.83	17.51	18.48	19.73	19.88	-0.0429375285737693	5.68824331261835	0.571766834161658	0.861466501023646	17:35350304-35373701:-	SLFN11	11;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0016235,cellular_component aggresome;GO:0051607,biological_process defense response to virus;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	schlafen family member 11 [Source:HGNC Symbol%3BAcc:HGNC:26633]
ENSG00000170647	9.12	12.10	8.56	6.77	10.19	10.18	0.125613951258702	1.92284638646724	0.571789454759834	0.861466501023646	11:100991988-100993941:+	TMEM133	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 133 [Source:HGNC Symbol%3BAcc:HGNC:24033]
ENSG00000137936	34.17	31.44	32.44	33.50	30.44	32.37	0.0390512264609585	6.37737105266346	0.57192840529862	0.861565949224466	1:93561785-93847150:-	BCAR3	11;GO:0002089,biological_process lens morphogenesis in camera-type eye;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0042493,biological_process response to drug;GO:0043547,biological_process positive regulation of GTPase activity	NA	breast cancer anti-estrogen resistance 3 [Source:HGNC Symbol%3BAcc:HGNC:973]
ENSG00000089692	0.80	0.90	0.46	0.66	0.85	0.31	0.245209002293625	0.25284525903452	0.572046278353121	0.861565949224466	12:6772511-6778455:+	LAG3	12;GO:0003823,molecular_function antigen binding;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042289,molecular_function MHC class II protein binding;GO:0045085,biological_process negative regulation of interleukin-2 biosynthetic process;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0050868,biological_process negative regulation of T cell activation	NA	lymphocyte activating 3 [Source:HGNC Symbol%3BAcc:HGNC:6476]
ENSG00000164045	4.30	4.18	3.69	4.37	3.85	4.82	-0.091860579191297	2.76272190938801	0.572098654466104	0.861565949224466	3:48157145-48188402:-	CDC25A	25;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0009314,biological_process response to radiation;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019901,molecular_function protein kinase binding;GO:0034644,biological_process cellular response to UV;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0051087,molecular_function chaperone binding;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle;GO:1902751,biological_process positive regulation of cell cycle G2/M phase transition	CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]; K06645	cell division cycle 25A [Source:HGNC Symbol%3BAcc:HGNC:1725]
ENSG00000106080	30.00	37.00	30.46	27.70	33.88	32.18	0.058991687028686	4.35155442744901	0.572171062854039	0.861565949224466	7:30010586-30026684:-	FKBP14	11;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005509,molecular_function calcium ion binding;GO:0005528,molecular_function FK506 binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0016853,molecular_function isomerase activity;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0046872,molecular_function metal ion binding;GO:0061077,biological_process chaperone-mediated protein folding	NA	FK506 binding protein 14 [Source:HGNC Symbol%3BAcc:HGNC:18625]
ENSG00000188315	6.41	6.02	6.33	5.89	5.88	5.96	0.0968831945630628	2.37305971919387	0.572202504262185	0.861565949224466	3:49268601-49277909:-	C3orf62	1;GO:0005515,molecular_function protein binding	NA	chromosome 3 open reading frame 62 [Source:HGNC Symbol%3BAcc:HGNC:24771]
ENSG00000183773	0.66	0.63	0.84	0.45	0.62	0.77	0.223095942024091	0.45183021594975	0.57241625710864	0.861783262521473	22:20965107-20981360:+	AIFM3	12;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0097194,biological_process execution phase of apoptosis	NA	apoptosis inducing factor%2C mitochondria associated 3 [Source:HGNC Symbol%3BAcc:HGNC:26398]
ENSG00000169689	37.09	31.56	27.85	31.25	31.31	30.32	0.0700652334270977	3.80012018697505	0.572525380704352	0.861843020941441	17:82018701-82024107:-	CENPX	21;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0031297,biological_process replication fork processing;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0051301,biological_process cell division;GO:0051382,biological_process kinetochore assembly;GO:0071821,cellular_component FANCM-MHF complex	STRA13, CENPX, MHF2; centromere protein X; K15360	centromere protein X [Source:HGNC Symbol%3BAcc:HGNC:11422]
ENSG00000242485	64.16	56.82	57.25	55.31	62.75	56.17	0.0478818737239362	5.29718217969198	0.573140193270042	0.862663904336247	1:1401907-1407313:-	MRPL20	15;GO:0000027,biological_process ribosomal large subunit assembly;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0019843,molecular_function rRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L20 [Source:HGNC Symbol%3BAcc:HGNC:14478]
ENSG00000023734	144.62	156.12	143.69	143.21	154.05	138.89	0.0379487789966506	7.3221057496741	0.573248762658813	0.862722707430146	12:15882390-15903478:+	STRAP	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0003723,molecular_function RNA binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0030277,biological_process maintenance of gastrointestinal epithelium;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060394,biological_process negative regulation of pathway-restricted SMAD protein phosphorylation	STRAP, UNRIP; serine-threonine kinase receptor-associated protein; K13137	serine/threonine kinase receptor associated protein [Source:HGNC Symbol%3BAcc:HGNC:30796]
ENSG00000198464	8.21	8.53	8.60	7.96	9.80	8.92	-0.063043345323015	3.89946732838642	0.573344355201454	0.862738248177133	19:52297176-52325922:+	ZNF480	8;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 480 [Source:HGNC Symbol%3BAcc:HGNC:23305]
ENSG00000131849	2.69	2.37	2.80	2.69	3.09	2.68	-0.0816843734939742	2.65918548607332	0.573423924388915	0.862738248177133	19:58432813-58440222:-	ZNF132	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 132 [Source:HGNC Symbol%3BAcc:HGNC:12916]
ENSG00000148362	24.81	25.30	22.25	25.57	21.56	22.52	0.0633403793803949	3.86982269563848	0.573467597334208	0.862738248177133	9:136992417-136993984:+	PAXX	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0032947,molecular_function protein complex scaffold;GO:0035861,cellular_component site of double-strand break;GO:0042803,molecular_function protein homodimerization activity;GO:0043564,cellular_component Ku70:Ku80 complex;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0070062,cellular_component extracellular exosome;GO:0070419,cellular_component nonhomologous end joining complex	NA	PAXX%2C non-homologous end joining factor [Source:HGNC Symbol%3BAcc:HGNC:27849]
ENSG00000100263	11.89	11.38	13.03	10.55	11.58	12.94	0.0632412843253868	3.94257923843168	0.573775035567828	0.863004274440919	22:29259851-29268209:-	RHBDD3	12;GO:0000165,biological_process MAPK cascade;GO:0001889,biological_process liver development;GO:0002673,biological_process regulation of acute inflammatory response;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005622,cellular_component intracellular;GO:0006508,biological_process proteolysis;GO:0009410,biological_process response to xenobiotic stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032815,biological_process negative regulation of natural killer cell activation;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0050708,biological_process regulation of protein secretion	NA	rhomboid domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:1308]
ENSG00000037637	13.02	13.83	13.37	13.05	13.29	12.97	0.0425581914343388	4.85252864129678	0.573794340186865	0.863004274440919	1:16246838-16352454:-	FBXO42	1;GO:0005515,molecular_function protein binding	NA	F-box protein 42 [Source:HGNC Symbol%3BAcc:HGNC:29249]
ENSG00000155957	12.04	11.67	9.96	9.97	11.10	11.14	0.0729637867598501	3.33983678895097	0.573852999374474	0.863004274440919	12:66135845-66170072:-	TMBIM4	9;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0050848,biological_process regulation of calcium-mediated signaling	NA	transmembrane BAX inhibitor motif containing 4 [Source:HGNC Symbol%3BAcc:HGNC:24257]
ENSG00000168872	2.64	2.79	2.89	2.99	3.41	2.63	-0.104459976637491	2.23674794870286	0.573941041689219	0.863032119986466	16:70346828-70373383:+	DDX19A	23;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0008380,biological_process RNA splicing;GO:0010468,biological_process regulation of gene expression;GO:0010501,biological_process RNA secondary structure unwinding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031965,cellular_component nuclear membrane;GO:0051028,biological_process mRNA transport;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	DEAD-box helicase 19A [Source:HGNC Symbol%3BAcc:HGNC:25628]
ENSG00000151208	8.97	7.89	8.32	9.14	8.44	8.57	-0.0395221574793053	5.64971476302962	0.574047425548079	0.863087008981267	10:77790790-77926526:-	DLG5	38;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0006461,biological_process protein complex assembly;GO:0007165,biological_process signal transduction;GO:0008013,molecular_function beta-catenin binding;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030011,biological_process maintenance of cell polarity;GO:0030054,cellular_component cell junction;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030336,biological_process negative regulation of cell migration;GO:0030859,biological_process polarized epithelial cell differentiation;GO:0030901,biological_process midbrain development;GO:0035331,biological_process negative regulation of hippo signaling;GO:0035332,biological_process positive regulation of hippo signaling;GO:0035556,biological_process intracellular signal transduction;GO:0036064,cellular_component ciliary basal body;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0045176,biological_process apical protein localization;GO:0045186,biological_process zonula adherens assembly;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0051965,biological_process positive regulation of synapse assembly;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0071896,biological_process protein localization to adherens junction;GO:0072205,biological_process metanephric collecting duct development	NA	discs large MAGUK scaffold protein 5 [Source:HGNC Symbol%3BAcc:HGNC:2904]
ENSG00000176749	1.30	1.25	1.12	1.79	1.48	0.99	-0.197195709890984	0.452283867478458	0.574116606232041	0.863087008981267	17:32486618-32491256:+	CDK5R1	61;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001764,biological_process neuron migration;GO:0004672,molecular_function protein kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007158,biological_process neuron cell-cell adhesion;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0007413,biological_process axonal fasciculation;GO:0007420,biological_process brain development;GO:0008283,biological_process cell proliferation;GO:0009790,biological_process embryo development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016533,cellular_component cyclin-dependent protein kinase 5 holoenzyme complex;GO:0016534,molecular_function cyclin-dependent protein kinase 5 activator activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0021549,biological_process cerebellum development;GO:0021722,biological_process superior olivary nucleus maturation;GO:0021766,biological_process hippocampus development;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0021819,biological_process layer formation in cerebral cortex;GO:0030182,biological_process neuron differentiation;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030517,biological_process negative regulation of axon extension;GO:0031175,biological_process neuron projection development;GO:0031594,cellular_component neuromuscular junction;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0042501,biological_process serine phosphorylation of STAT protein;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043292,cellular_component contractile fiber;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0045296,molecular_function cadherin binding;GO:0045664,biological_process regulation of neuron differentiation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048511,biological_process rhythmic process;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	CDK5R1; cyclin-dependent kinase 5 activator 1; K11716	cyclin dependent kinase 5 regulatory subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:1775]
ENSG00000064666	94.02	92.61	88.70	88.08	93.45	89.20	0.0358704777539681	6.88018719465065	0.574259355624862	0.863197067252532	19:1026580-1039068:+	CNN2	24;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005576,cellular_component extracellular region;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0007010,biological_process cytoskeleton organization;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0030097,biological_process hemopoiesis;GO:0030336,biological_process negative regulation of cell migration;GO:0031032,biological_process actomyosin structure organization;GO:0032970,biological_process regulation of actin filament-based process;GO:0035580,cellular_component specific granule lumen;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0043312,biological_process neutrophil degranulation;GO:0045296,molecular_function cadherin binding;GO:0050765,biological_process negative regulation of phagocytosis;GO:0070062,cellular_component extracellular exosome;GO:0071260,biological_process cellular response to mechanical stimulus;GO:1904724,cellular_component tertiary granule lumen	NA	calponin 2 [Source:HGNC Symbol%3BAcc:HGNC:2156]
ENSG00000161642	1.31	2.06	1.93	2.02	2.28	1.63	-0.164501107646955	1.35656812220374	0.574452195326436	0.863318599772033	12:54369132-54391298:-	ZNF385A	34;GO:0000790,cellular_component nuclear chromatin;GO:0002039,molecular_function p53 binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007599,biological_process hemostasis;GO:0007611,biological_process learning or memory;GO:0007626,biological_process locomotory behavior;GO:0008270,molecular_function zinc ion binding;GO:0008298,biological_process intracellular mRNA localization;GO:0010609,biological_process mRNA localization resulting in posttranscriptional regulation of gene expression;GO:0030220,biological_process platelet formation;GO:0030425,cellular_component dendrite;GO:0035855,biological_process megakaryocyte development;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0070889,biological_process platelet alpha granule organization;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902164,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000765,biological_process regulation of cytoplasmic translation	NA	zinc finger protein 385A [Source:HGNC Symbol%3BAcc:HGNC:17521]
ENSG00000162302	13.42	15.56	15.22	14.26	14.18	14.66	0.0431907907909387	5.07985300709711	0.574479306704019	0.863318599772033	11:64359147-64372215:+	RPS6KA4	29;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001818,biological_process negative regulation of cytokine production;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004711,molecular_function ribosomal protein S6 kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016572,biological_process histone phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035556,biological_process intracellular signal transduction;GO:0043987,biological_process histone H3-S10 phosphorylation;GO:0043988,biological_process histone H3-S28 phosphorylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070498,biological_process interleukin-1-mediated signaling pathway	RPS6KA4, MSK2; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]; K16510	ribosomal protein S6 kinase A4 [Source:HGNC Symbol%3BAcc:HGNC:10433]
ENSG00000175155	19.39	19.27	20.20	22.44	18.91	21.47	-0.0815934228367779	2.88895518206015	0.574615211529615	0.863418305376723	17:59331688-59401729:+	YPEL2	3;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0046872,molecular_function metal ion binding	NA	yippee like 2 [Source:HGNC Symbol%3BAcc:HGNC:18326]
ENSG00000258388	1.45	0.31	1.27	0.97	1.47	1.29	-0.220377897110775	0.295579429682307	0.574897924219396	0.863595769825424	6:32153844-32171978:+	PPT2-EGFL8	6;GO:0008474,molecular_function palmitoyl-(protein) hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016790,molecular_function thiolester hydrolase activity;GO:0098599,molecular_function palmitoyl hydrolase activity;GO:0098734,biological_process macromolecule depalmitoylation	PPT; palmitoyl-protein thioesterase [EC:3.1.2.22]; K01074	PPT2-EGFL8 readthrough (NMD candidate) [Source:HGNC Symbol%3BAcc:HGNC:48343]
ENSG00000132294	55.86	47.22	56.14	53.18	53.39	58.95	-0.0423840350932144	7.11462972553936	0.575010444480079	0.863595769825424	8:131904087-132013642:+	EFR3A	8;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0070062,cellular_component extracellular exosome;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	EFR3 homolog A [Source:HGNC Symbol%3BAcc:HGNC:28970]
ENSG00000204231	33.27	30.73	33.58	30.86	32.15	32.87	0.0400308044314021	5.70511298835352	0.575123846510443	0.863595769825424	6:33193587-33200688:-	RXRB	21;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004886,molecular_function 9-cis retinoic acid receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048384,biological_process retinoic acid receptor signaling pathway	RXRB, NR2B2; retinoid X receptor beta; K08525	retinoid X receptor beta [Source:HGNC Symbol%3BAcc:HGNC:10478]
ENSG00000105865	22.34	22.72	22.46	20.78	24.38	25.47	-0.0551331502554086	4.50708511880708	0.575128071170706	0.863595769825424	7:107563483-107578464:+	DUS4L	7;GO:0002943,biological_process tRNA dihydrouridine synthesis;GO:0003824,molecular_function catalytic activity;GO:0008033,biological_process tRNA processing;GO:0016491,molecular_function oxidoreductase activity;GO:0017150,molecular_function tRNA dihydrouridine synthase activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	dihydrouridine synthase 4 like [Source:HGNC Symbol%3BAcc:HGNC:21517]
ENSG00000183569	8.11	4.89	10.37	7.19	5.30	8.95	0.14563018187538	2.88939799441984	0.575213791722353	0.863595769825424	22:42553616-42574382:+	SERHL2	9;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	serine hydrolase like 2 [Source:HGNC Symbol%3BAcc:HGNC:29446]
ENSG00000184154	8.39	8.93	8.53	8.72	9.67	8.72	-0.0594045149171977	3.94960065118224	0.575239767621491	0.863595769825424	11:72080330-72110782:+	LRTOMT	17;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006584,biological_process catecholamine metabolic process;GO:0007605,biological_process sensory perception of sound;GO:0008168,molecular_function methyltransferase activity;GO:0008171,molecular_function O-methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016206,molecular_function catechol O-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0042135,biological_process neurotransmitter catabolic process;GO:0042424,biological_process catecholamine catabolic process;GO:0060117,biological_process auditory receptor cell development;GO:0102084,molecular_function L-dopa O-methyltransferase activity;GO:0102938,molecular_function orcinol O-methyltransferase activity	NA	leucine rich transmembrane and O-methyltransferase domain containing [Source:HGNC Symbol%3BAcc:HGNC:25033]
ENSG00000104856	6.62	5.60	5.73	6.56	4.48	6.04	0.087256157350068	3.38582716572682	0.575279427880011	0.863595769825424	19:45001429-45038198:+	RELB	39;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0010628,biological_process positive regulation of gene expression;GO:0019882,biological_process antigen processing and presentation;GO:0019901,molecular_function protein kinase binding;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0032922,biological_process circadian regulation of gene expression;GO:0033256,cellular_component I-kappaB/NF-kappaB complex;GO:0034097,biological_process response to cytokine;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0042088,biological_process T-helper 1 type immune response;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0043234,cellular_component protein complex;GO:0045063,biological_process T-helper 1 cell differentiation;GO:0045087,biological_process innate immune response;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process;GO:0071470,biological_process cellular response to osmotic stress	RELB; transcription factor RelB; K09253	RELB proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol%3BAcc:HGNC:9956]
ENSG00000132801	1.76	2.01	2.15	1.90	1.63	1.99	0.106239093771946	2.04630312070676	0.575368608477727	0.863595769825424	20:45857616-45879122:+	ZSWIM3	2;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger SWIM-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:16157]
ENSG00000184634	16.62	16.80	17.77	17.35	16.45	16.54	0.0364970228310175	6.80048232394658	0.575402385531289	0.863595769825424	X:71118555-71142454:+	MED12	48;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001756,biological_process somitogenesis;GO:0001843,biological_process neural tube closure;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007492,biological_process endoderm development;GO:0007507,biological_process heart development;GO:0008013,molecular_function beta-catenin binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0014003,biological_process oligodendrocyte development;GO:0014044,biological_process Schwann cell development;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0019904,molecular_function protein domain specific binding;GO:0021510,biological_process spinal cord development;GO:0021915,biological_process neural tube development;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0036342,biological_process post-anal tail morphogenesis;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0048568,biological_process embryonic organ development;GO:0048702,biological_process embryonic neurocranium morphogenesis;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0090245,biological_process axis elongation involved in somitogenesis;GO:1990403,biological_process embryonic brain development	MED12; mediator of RNA polymerase II transcription subunit 12; K15162	mediator complex subunit 12 [Source:HGNC Symbol%3BAcc:HGNC:11957]
ENSG00000135108	15.11	16.29	15.52	18.37	14.24	16.45	-0.0555751449365197	4.93821794315584	0.575488133980207	0.863595769825424	12:117141987-117190531:-	FBXO21	7;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	F-box protein 21 [Source:HGNC Symbol%3BAcc:HGNC:13592]
ENSG00000100908	30.46	25.29	27.55	25.50	26.72	28.68	0.0600770650519387	4.24255922372942	0.575498606944003	0.863595769825424	14:24138958-24141588:-	EMC9	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 9 [Source:HGNC Symbol%3BAcc:HGNC:20273]
ENSG00000182446	27.23	26.83	27.42	28.54	27.06	28.62	-0.0356319944807159	5.98762661574046	0.575702652880572	0.863750844212122	17:81556886-81648465:-	NPLOC4	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007030,biological_process Golgi organization;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032480,biological_process negative regulation of type I interferon production;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0036501,cellular_component UFD1-NPL4 complex;GO:0039536,biological_process negative regulation of RIG-I signaling pathway;GO:0042175,cellular_component nuclear outer membrane-endoplasmic reticulum membrane network;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070987,biological_process error-free translesion synthesis	NPLOC4, NPL4; nuclear protein localization protein 4 homolog; K14015	NPL4 homolog%2C ubiquitin recognition factor [Source:HGNC Symbol%3BAcc:HGNC:18261]
ENSG00000176055	2.81	2.63	1.88	2.67	2.40	1.51	0.166977469621668	1.26798046527976	0.575741116975034	0.863750844212122	5:90458202-90474768:-	MBLAC2	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	metallo-beta-lactamase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:33711]
ENSG00000164169	3.90	5.35	3.86	4.84	4.16	3.30	0.0945063575941754	3.43243794756128	0.575953892839613	0.863965640098866	4:147637784-147684230:-	PRMT9	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0019918,biological_process peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0032259,biological_process methylation;GO:0035243,molecular_function protein-arginine omega-N symmetric methyltransferase activity;GO:0035246,biological_process peptidyl-arginine N-methylation	NA	protein arginine methyltransferase 9 [Source:HGNC Symbol%3BAcc:HGNC:25099]
ENSG00000159445	11.93	12.80	12.71	10.68	12.53	12.67	0.0688471351371915	3.30888239793576	0.576121353176926	0.864048885003297	1:151873583-151909808:-	THEM4	20;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016290,molecular_function palmitoyl-CoA hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043491,biological_process protein kinase B signaling;GO:0047617,molecular_function acyl-CoA hydrolase activity;GO:0102991,molecular_function myristoyl-CoA hydrolase activity;GO:1902108,biological_process regulation of mitochondrial membrane permeability involved in apoptotic process	THEM4, CTMP; acyl-coenzyme A thioesterase THEM4 [EC:3.1.2.2]; K16339	thioesterase superfamily member 4 [Source:HGNC Symbol%3BAcc:HGNC:17947]
ENSG00000157077	12.90	12.41	13.12	12.79	13.04	13.96	-0.0373390685277923	5.8061750690311	0.576148603977466	0.864048885003297	1:52142093-52346686:+	ZFYVE9	18;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006897,biological_process endocytosis;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007183,biological_process SMAD protein complex assembly;GO:0007184,biological_process SMAD protein import into nucleus;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0031901,cellular_component early endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding	MADHIP, SARA; MAD, mothers against decapentaplegic interacting protein; K04679	zinc finger FYVE-type containing 9 [Source:HGNC Symbol%3BAcc:HGNC:6775]
ENSG00000064726	46.60	47.72	47.29	42.15	47.41	49.26	0.0393700690000363	6.08246143879007	0.576282688835919	0.864114044432855	15:83016421-83067354:-	BTBD1	14;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0022008,biological_process neurogenesis;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0043393,biological_process regulation of protein binding;GO:0043687,biological_process post-translational protein modification	NA	BTB domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:1120]
ENSG00000197323	8.14	9.27	9.19	8.28	8.68	8.96	0.0446939258099955	4.92392466048364	0.576331279614888	0.864114044432855	1:114392776-114511160:-	TRIM33	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070410,molecular_function co-SMAD binding;GO:0070412,molecular_function R-SMAD binding	NA	tripartite motif containing 33 [Source:HGNC Symbol%3BAcc:HGNC:16290]
ENSG00000115368	26.25	23.50	25.66	26.19	23.11	24.67	0.0420369147539749	6.02125068531526	0.576577102650435	0.864136276686829	2:189441432-189475565:+	WDR75	12;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0042254,biological_process ribosome biogenesis;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:2000234,biological_process positive regulation of rRNA processing	NAN1, UTP17, WDR75; NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17); K14552	WD repeat domain 75 [Source:HGNC Symbol%3BAcc:HGNC:25725]
ENSG00000167088	126.02	115.91	106.79	122.48	115.57	124.48	-0.0439960419702441	5.41004370360018	0.576620013182473	0.864136276686829	18:21612266-21633524:+	SNRPD1	30;GO:0000243,cellular_component commitment complex;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005685,cellular_component U1 snRNP;GO:0005686,cellular_component U2 snRNP;GO:0005687,cellular_component U4 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0034709,cellular_component methylosome;GO:0034715,cellular_component pICln-Sm protein complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0071010,cellular_component prespliceosome;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097526,cellular_component spliceosomal tri-snRNP complex;GO:1990446,molecular_function U1 snRNP binding	SNRPD1, SMD1; small nuclear ribonucleoprotein D1; K11087	small nuclear ribonucleoprotein D1 polypeptide [Source:HGNC Symbol%3BAcc:HGNC:11158]
ENSG00000148843	9.32	9.02	9.58	9.44	8.80	9.19	0.0385946004389805	5.70290174061325	0.57668478599769	0.864136276686829	10:103396647-103446292:+	PDCD11	14;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466,biological_process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008134,molecular_function transcription factor binding;GO:0032040,cellular_component small-subunit processome	NA	programmed cell death 11 [Source:HGNC Symbol%3BAcc:HGNC:13408]
ENSG00000137770	21.70	21.94	22.06	23.05	21.42	23.73	-0.0437204201541732	5.02913073552659	0.576723476711371	0.864136276686829	15:44427233-44529038:+	CTDSPL2	8;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0046827,biological_process positive regulation of protein export from nucleus	NA	CTD small phosphatase like 2 [Source:HGNC Symbol%3BAcc:HGNC:26936]
ENSG00000067829	30.78	31.69	27.76	30.98	28.49	28.68	0.0424824623922865	5.34536736014608	0.576729133964567	0.864136276686829	X:153785765-153794523:-	IDH3G	16;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004449,molecular_function isocitrate dehydrogenase (NAD+) activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006102,biological_process isocitrate metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0046872,molecular_function metal ion binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process	IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]; K00030	isocitrate dehydrogenase 3 (NAD(+)) gamma [Source:HGNC Symbol%3BAcc:HGNC:5386]
ENSG00000124608	6.31	6.40	6.03	6.44	7.08	6.12	-0.0560073030798851	4.25172514409042	0.576763800237685	0.864136276686829	6:44299653-44313326:-	AARS2	19;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004813,molecular_function alanine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006400,biological_process tRNA modification;GO:0006412,biological_process translation;GO:0006419,biological_process alanyl-tRNA aminoacylation;GO:0016597,molecular_function amino acid binding;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0033108,biological_process mitochondrial respiratory chain complex assembly;GO:0043039,biological_process tRNA aminoacylation;GO:0046872,molecular_function metal ion binding;GO:0070143,biological_process mitochondrial alanyl-tRNA aminoacylation	AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]; K01872	alanyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:21022]
ENSG00000159335	548.78	586.12	525.01	526.45	582.98	518.48	0.0391550981626633	7.71490987550223	0.577106656117224	0.864422372111523	12:6765515-6770952:+	PTMS	3;GO:0002376,biological_process immune system process;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication	NA	parathymosin [Source:HGNC Symbol%3BAcc:HGNC:9629]
ENSG00000163214	7.54	7.48	7.57	8.01	7.13	8.36	-0.0463687999810803	5.01329854368002	0.577116556681535	0.864422372111523	2:38797728-38875934:-	DHX57	11;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0006396,biological_process RNA processing;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	DExH-box helicase 57 [Source:HGNC Symbol%3BAcc:HGNC:20086]
ENSG00000181450	0.93	1.20	0.77	1.31	1.25	0.73	-0.186014871707432	1.01126849143019	0.577226952773748	0.864422372111523	1:227563542-227677443:+	ZNF678	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 678 [Source:HGNC Symbol%3BAcc:HGNC:28652]
ENSG00000105877	2.49	2.73	2.05	2.23	2.44	2.38	0.0528646390719108	5.02230183882953	0.577281515987563	0.864422372111523	7:21543214-21901839:+	DNAH11	23;GO:0000166,molecular_function nucleotide binding;GO:0003341,biological_process cilium movement;GO:0003356,biological_process regulation of cilium beat frequency;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007018,biological_process microtubule-based movement;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0016887,molecular_function ATPase activity;GO:0030286,cellular_component dynein complex;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding	NA	dynein axonemal heavy chain 11 [Source:HGNC Symbol%3BAcc:HGNC:2942]
ENSG00000108187	8.28	8.26	7.17	6.92	8.75	6.85	0.0858058002468735	2.97927589249636	0.577302945686339	0.864422372111523	10:68282659-68333049:-	PBLD	15;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0009058,biological_process biosynthetic process;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0016853,molecular_function isomerase activity;GO:0030277,biological_process maintenance of gastrointestinal epithelium;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060392,biological_process negative regulation of SMAD protein import into nucleus;GO:0060394,biological_process negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0070062,cellular_component extracellular exosome	NA	phenazine biosynthesis like protein domain containing [Source:HGNC Symbol%3BAcc:HGNC:23301]
ENSG00000153113	55.29	53.02	54.92	54.16	51.63	54.91	0.0347096112489641	7.17678734454861	0.577705582629705	0.86482872883551	5:96525266-96779595:+	CAST	13;GO:0003723,molecular_function RNA binding;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004869,molecular_function cysteine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010859,molecular_function calcium-dependent cysteine-type endopeptidase inhibitor activity;GO:0016020,cellular_component membrane;GO:0030414,molecular_function peptidase inhibitor activity;GO:0045296,molecular_function cadherin binding;GO:0097340,biological_process inhibition of cysteine-type endopeptidase activity;GO:2000675,biological_process negative regulation of type B pancreatic cell apoptotic process	CAST; calpastatin; K04281	calpastatin [Source:HGNC Symbol%3BAcc:HGNC:1515]
ENSG00000183741	17.71	19.48	17.86	19.75	18.29	19.29	-0.0519289096931525	4.5416876644974	0.577713672722472	0.86482872883551	22:38861449-38872314:-	CBX6	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000792,cellular_component heterochromatin;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0031519,cellular_component PcG protein complex	NA	chromobox 6 [Source:HGNC Symbol%3BAcc:HGNC:1556]
ENSG00000117713	13.61	13.94	13.98	14.16	15.06	13.74	-0.0369366008689088	6.61286815278183	0.577848833627268	0.864893292002691	1:26693235-26782104:+	ARID1A	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001704,biological_process formation of primary germ layer;GO:0001843,biological_process neural tube closure;GO:0003205,biological_process cardiac chamber development;GO:0003408,biological_process optic cup formation involved in camera-type eye development;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006325,biological_process chromatin organization;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006344,biological_process maintenance of chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007369,biological_process gastrulation;GO:0007399,biological_process nervous system development;GO:0007566,biological_process embryo implantation;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019827,biological_process stem cell population maintenance;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030900,biological_process forebrain development;GO:0031491,molecular_function nucleosome binding;GO:0042766,biological_process nucleosome mobilization;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060674,biological_process placenta blood vessel development;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:0090544,cellular_component BAF-type complex;GO:1901998,biological_process toxin transport	ARID1; AT-rich interactive domain-containing protein 1; K11653	AT-rich interaction domain 1A [Source:HGNC Symbol%3BAcc:HGNC:11110]
ENSG00000105849	13.51	12.53	13.79	12.40	15.18	14.42	-0.06049573397439	3.80951399245374	0.577896154343859	0.864893292002691	7:19695461-19709087:-	TWISTNB	12;GO:0001054,molecular_function RNA polymerase I activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:1990830,biological_process cellular response to leukemia inhibitory factor	RPA43; DNA-directed RNA polymerase I subunit RPA43; K03004	TWIST neighbor [Source:HGNC Symbol%3BAcc:HGNC:18027]
ENSG00000196576	74.57	72.68	75.43	77.27	76.06	76.16	-0.0314977037500948	8.71835854536733	0.578170135053304	0.86494330080392	22:50274978-50307627:-	PLXNB2	22;GO:0001843,biological_process neural tube closure;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007405,biological_process neuroblast proliferation;GO:0007420,biological_process brain development;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0043087,biological_process regulation of GTPase activity;GO:0050772,biological_process positive regulation of axonogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:2001222,biological_process regulation of neuron migration	PLXNB; plexin B; K06821	plexin B2 [Source:HGNC Symbol%3BAcc:HGNC:9104]
ENSG00000111837	1.94	1.34	1.84	1.99	1.44	1.30	0.148637746246374	1.78911569781106	0.578175164485145	0.86494330080392	6:10762722-10838555:-	MAK	34;GO:0000166,molecular_function nucleotide binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0003713,molecular_function transcription coactivator activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0030496,cellular_component midbody;GO:0035556,biological_process intracellular signal transduction;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0045494,biological_process photoreceptor cell maintenance;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0060271,biological_process cilium morphogenesis;GO:0072686,cellular_component mitotic spindle	NA	male germ cell associated kinase [Source:HGNC Symbol%3BAcc:HGNC:6816]
ENSG00000197561	1.85	0.95	1.47	1.68	0.57	1.49	0.227956261322159	0.311004394110633	0.578213337588201	0.86494330080392	19:851013-856247:+	ELANE	48;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001878,biological_process response to yeast;GO:0002020,molecular_function protease binding;GO:0002438,biological_process acute inflammatory response to antigenic stimulus;GO:0002523,biological_process leukocyte migration involved in inflammatory response;GO:0002812,biological_process biosynthetic process of antibacterial peptides active against Gram-negative bacteria;GO:0004175,molecular_function endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006909,biological_process phagocytosis;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009411,biological_process response to UV;GO:0009986,cellular_component cell surface;GO:0016787,molecular_function hydrolase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019730,biological_process antimicrobial humoral response;GO:0019955,molecular_function cytokine binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0030141,cellular_component secretory granule;GO:0030163,biological_process protein catabolic process;GO:0032496,biological_process response to lipopolysaccharide;GO:0035578,cellular_component azurophil granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0042742,biological_process defense response to bacterium;GO:0043312,biological_process neutrophil degranulation;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0044130,biological_process negative regulation of growth of symbiont in host;GO:0045079,biological_process negative regulation of chemokine biosynthetic process;GO:0045415,biological_process negative regulation of interleukin-8 biosynthetic process;GO:0045416,biological_process positive regulation of interleukin-8 biosynthetic process;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050778,biological_process positive regulation of immune response;GO:0050832,biological_process defense response to fungus;GO:0050900,biological_process leukocyte migration;GO:0050922,biological_process negative regulation of chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:0070945,biological_process neutrophil mediated killing of gram-negative bacterium;GO:0070947,biological_process neutrophil mediated killing of fungus;GO:1903238,biological_process positive regulation of leukocyte tethering or rolling	ELANE; leukocyte elastase [EC:3.4.21.37]; K01327	elastase%2C neutrophil expressed [Source:HGNC Symbol%3BAcc:HGNC:3309]
ENSG00000177106	154.31	150.38	159.27	158.18	158.44	161.78	-0.0321224120805706	8.43562603879924	0.578243342907609	0.86494330080392	11:694437-727727:+	EPS8L2	15;GO:0003779,molecular_function actin binding;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007266,biological_process Rho protein signal transduction;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0031982,cellular_component vesicle;GO:0032587,cellular_component ruffle membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:1900029,biological_process positive regulation of ruffle assembly	NA	EPS8 like 2 [Source:HGNC Symbol%3BAcc:HGNC:21296]
ENSG00000160298	8.84	9.56	8.82	9.24	7.86	8.93	0.0697236048667214	3.32031648126237	0.578295147467072	0.86494330080392	21:46300180-46323875:-	C21orf58	NA	NA	chromosome 21 open reading frame 58 [Source:HGNC Symbol%3BAcc:HGNC:1300]
ENSG00000133703	19.40	13.12	16.11	17.67	16.28	18.01	-0.0704582736459584	3.58012656566537	0.578347651387459	0.86494330080392	12:25204788-25250936:-	KRAS	51;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001889,biological_process liver development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007411,biological_process axon guidance;GO:0007565,biological_process female pregnancy;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008542,biological_process visual learning;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019002,molecular_function GMP binding;GO:0019003,molecular_function GDP binding;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0021897,biological_process forebrain astrocyte development;GO:0030036,biological_process actin cytoskeleton organization;GO:0030275,molecular_function LRR domain binding;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031647,biological_process regulation of protein stability;GO:0032228,biological_process regulation of synaptic transmission, GABAergic;GO:0032403,molecular_function protein complex binding;GO:0035022,biological_process positive regulation of Rac protein signal transduction;GO:0035900,biological_process response to isolation stress;GO:0038002,biological_process endocrine signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045121,cellular_component membrane raft;GO:0045596,biological_process negative regulation of cell differentiation;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050900,biological_process leukocyte migration;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051146,biological_process striated muscle cell differentiation;GO:0051384,biological_process response to glucocorticoid;GO:0051385,biological_process response to mineralocorticoid;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:2000774,biological_process positive regulation of cellular senescence	KRAS, KRAS2; GTPase KRas; K07827	KRAS proto-oncogene%2C GTPase [Source:HGNC Symbol%3BAcc:HGNC:6407]
ENSG00000179886	5.39	5.56	6.27	5.91	4.69	5.88	0.0750359593571964	3.4567651371317	0.578631484899376	0.865263537170937	8:143597834-143603224:+	TIGD5	6;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process	NA	tigger transposable element derived 5 [Source:HGNC Symbol%3BAcc:HGNC:18336]
ENSG00000110048	24.36	25.54	27.33	26.13	23.28	26.26	0.0407756282951277	5.9515237944966	0.578701239755137	0.865263609862747	11:59574397-59616144:-	OSBP	23;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006699,biological_process bile acid biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008142,molecular_function oxysterol binding;GO:0008289,molecular_function lipid binding;GO:0015248,molecular_function sterol transporter activity;GO:0015918,biological_process sterol transport;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0044128,biological_process positive regulation of growth of symbiont in host;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	oxysterol binding protein [Source:HGNC Symbol%3BAcc:HGNC:8503]
ENSG00000126091	12.77	12.34	13.48	12.01	13.21	12.37	0.0531071815030323	4.41377437325731	0.57888912112253	0.865440281885338	1:43705823-43931165:+	ST3GAL3	17;GO:0000139,cellular_component Golgi membrane;GO:0003836,molecular_function beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008118,molecular_function N-acetyllactosaminide alpha-2,3-sialyltransferase activity;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0032580,cellular_component Golgi cisterna membrane;GO:0097503,biological_process sialylation	SIAT6; neolactotetraosylceramide alpha-2,3-sialyltransferase (sialyltransferase 6) [EC:2.4.99.6]; K00781	ST3 beta-galactoside alpha-2%2C3-sialyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:10866]
ENSG00000100077	2.36	1.53	1.85	2.18	2.24	1.91	-0.104708369647653	2.11763233520437	0.579084418653261	0.865540030286574	22:25564848-25729294:+	GRK3	14;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004703,molecular_function G-protein coupled receptor kinase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031623,biological_process receptor internalization;GO:0047696,molecular_function beta-adrenergic receptor kinase activity	ADRBK, GRK; beta-adrenergic-receptor kinase [EC:2.7.11.15]; K00910	G protein-coupled receptor kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:290]
ENSG00000167182	8.96	9.84	10.43	9.79	9.37	9.23	0.05282373074863	4.33611753033447	0.579095299406267	0.865540030286574	17:47896149-47928957:+	SP2	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0035264,biological_process multicellular organism growth;GO:0042826,molecular_function histone deacetylase binding;GO:0046872,molecular_function metal ion binding	NA	Sp2 transcription factor [Source:HGNC Symbol%3BAcc:HGNC:11207]
ENSG00000198598	0.74	0.95	0.57	0.70	0.59	0.66	0.195551042181851	0.492444910299941	0.579204741802615	0.865599381169739	12:131828392-131851783:+	MMP17	19;GO:0001822,biological_process kidney development;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0008047,molecular_function enzyme activator activity;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031012,cellular_component extracellular matrix;GO:0031225,cellular_component anchored component of membrane;GO:0042756,biological_process drinking behavior;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity	MMP17; matrix metalloproteinase-17 (membrane-inserted) [EC:3.4.24.-]; K07997	matrix metallopeptidase 17 [Source:HGNC Symbol%3BAcc:HGNC:7163]
ENSG00000047249	61.39	60.96	56.42	53.55	63.75	57.76	0.0417277634163295	6.43187013037537	0.579405014317036	0.865794443567758	8:53715556-53843558:-	ATP6V1H	24;GO:0000221,cellular_component vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006897,biological_process endocytosis;GO:0007035,biological_process vacuolar acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016032,biological_process viral process;GO:0016241,biological_process regulation of macroautophagy;GO:0016820,molecular_function hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;GO:0016887,molecular_function ATPase activity;GO:0030234,molecular_function enzyme regulator activity;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0050790,biological_process regulation of catalytic activity;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV1H; V-type H+-transporting ATPase subunit H; K02144	ATPase H+ transporting V1 subunit H [Source:HGNC Symbol%3BAcc:HGNC:18303]
ENSG00000156876	5.27	5.24	5.15	5.43	5.27	5.82	-0.067316749798511	3.42456944519731	0.579637017596523	0.865994200178158	1:100083562-100132955:-	SASS6	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007099,biological_process centriole replication;GO:0051298,biological_process centrosome duplication;GO:0098536,cellular_component deuterosome	NA	SAS-6 centriolar assembly protein [Source:HGNC Symbol%3BAcc:HGNC:25403]
ENSG00000166130	33.63	35.91	31.72	32.19	33.94	33.18	0.0368641716018378	5.97980454796417	0.579818454599893	0.865994200178158	12:98613404-98645113:-	IKBIP	6;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0010165,biological_process response to X-ray;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	IKBKB interacting protein [Source:HGNC Symbol%3BAcc:HGNC:26430]
ENSG00000088256	39.21	41.14	42.86	41.80	44.95	40.94	-0.0398730504765552	5.71511547472799	0.579870473352352	0.865994200178158	19:3094409-3124004:+	GNA11	30;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001508,biological_process action potential;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007507,biological_process heart development;GO:0007603,biological_process phototransduction, visible light;GO:0009649,biological_process entrainment of circadian clock;GO:0016020,cellular_component membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0030168,biological_process platelet activation;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031826,molecular_function type 2A serotonin receptor binding;GO:0045634,biological_process regulation of melanocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0048066,biological_process developmental pigmentation;GO:0060158,biological_process phospholipase C-activating dopamine receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071467,biological_process cellular response to pH	GNA11; guanine nucleotide-binding protein subunit alpha-11; K04635	G protein subunit alpha 11 [Source:HGNC Symbol%3BAcc:HGNC:4379]
ENSG00000044459	7.55	6.42	7.56	6.76	7.24	7.06	0.0513256073852096	4.92376382968467	0.580009809862379	0.865994200178158	9:17134981-17503923:+	CNTLN	12;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0010457,biological_process centriole-centriole cohesion;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030674,molecular_function protein binding, bridging;GO:0033365,biological_process protein localization to organelle;GO:0070062,cellular_component extracellular exosome	NA	centlein [Source:HGNC Symbol%3BAcc:HGNC:23432]
ENSG00000104886	22.30	23.18	22.56	19.55	22.61	23.96	0.0501057117855549	4.60308720346308	0.580039782261231	0.865994200178158	19:2230083-2237704:-	PLEKHJ1	7;GO:0001881,biological_process receptor recycling;GO:0005769,cellular_component early endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0007032,biological_process endosome organization;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0055037,cellular_component recycling endosome	NA	pleckstrin homology domain containing J1 [Source:HGNC Symbol%3BAcc:HGNC:18211]
ENSG00000143384	111.23	104.84	101.28	109.45	109.58	108.96	-0.0353834803659755	6.83743353157808	0.580145699887431	0.865994200178158	1:150574550-150579738:-	MCL1	33;GO:0001709,biological_process cell fate determination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0010507,biological_process negative regulation of autophagy;GO:0015266,molecular_function protein channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019725,biological_process cellular homeostasis;GO:0030154,biological_process cell differentiation;GO:0034097,biological_process response to cytokine;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0051434,molecular_function BH3 domain binding;GO:0071806,biological_process protein transmembrane transport;GO:0097136,cellular_component Bcl-2 family protein complex;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1903378,biological_process positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:2000811,biological_process negative regulation of anoikis;GO:2001020,biological_process regulation of response to DNA damage stimulus;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	MCL1; myeloid leukemia cell differntiation protein MCL-1; K02539	MCL1%2C BCL2 family apoptosis regulator [Source:HGNC Symbol%3BAcc:HGNC:6943]
ENSG00000143643	5.49	5.47	5.61	5.20	5.65	5.21	0.0583654788047907	3.93255748006908	0.580150422112167	0.865994200178158	1:230906242-230978875:-	TTC13	NA	NA	tetratricopeptide repeat domain 13 [Source:HGNC Symbol%3BAcc:HGNC:26204]
ENSG00000090686	38.05	37.71	35.57	36.74	35.82	36.98	0.0347054467815699	6.91347824905443	0.580245864432809	0.865994200178158	1:21678297-21783606:-	USP48	13;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 48 [Source:HGNC Symbol%3BAcc:HGNC:18533]
ENSG00000064309	3.76	2.46	3.52	2.98	3.67	3.80	-0.0776667908032365	3.73871094989643	0.580247555543577	0.865994200178158	11:125955795-126063335:-	CDON	29;GO:0001708,biological_process cell fate specification;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002088,biological_process lens development in camera-type eye;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007224,biological_process smoothened signaling pathway;GO:0007520,biological_process myoblast fusion;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010172,biological_process embryonic body morphogenesis;GO:0014816,biological_process skeletal muscle satellite cell differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021987,biological_process cerebral cortex development;GO:0031012,cellular_component extracellular matrix;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045664,biological_process regulation of neuron differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048598,biological_process embryonic morphogenesis;GO:0048643,biological_process positive regulation of skeletal muscle tissue development;GO:0051057,biological_process positive regulation of small GTPase mediated signal transduction;GO:0051146,biological_process striated muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0060059,biological_process embryonic retina morphogenesis in camera-type eye;GO:2000179,biological_process positive regulation of neural precursor cell proliferation	NA	cell adhesion associated%2C oncogene regulated [Source:HGNC Symbol%3BAcc:HGNC:17104]
ENSG00000180884	1.68	2.17	2.17	1.90	2.12	1.52	0.12645389736975	1.91793930893041	0.580262559629172	0.865994200178158	19:34956353-34964049:-	ZNF792	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 792 [Source:HGNC Symbol%3BAcc:HGNC:24751]
ENSG00000197312	4.21	4.28	5.37	4.22	4.90	5.88	-0.101434698567739	2.58152365656332	0.580306111099808	0.865994200178158	1:15617499-15669044:+	DDI2	5;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0042802,molecular_function identical protein binding;GO:0043130,molecular_function ubiquitin binding	NA	DNA damage inducible 1 homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:24578]
ENSG00000239305	21.65	19.44	20.09	19.24	22.11	18.44	0.0485126736026393	5.37942666937031	0.580460623512948	0.866120653884628	2:86603392-86623866:-	RNF103	14;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007417,biological_process central nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904380,biological_process endoplasmic reticulum mannose trimming	NA	ring finger protein 103 [Source:HGNC Symbol%3BAcc:HGNC:12859]
ENSG00000117318	5.93	10.17	5.57	6.08	11.68	6.70	-0.185484349746028	1.51332519761122	0.580602490804706	0.866170814910803	1:23557917-23559794:-	ID3	33;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001656,biological_process metanephros development;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006275,biological_process regulation of DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007417,biological_process central nervous system development;GO:0007507,biological_process heart development;GO:0007517,biological_process muscle organ development;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0009611,biological_process response to wounding;GO:0010629,biological_process negative regulation of gene expression;GO:0019904,molecular_function protein domain specific binding;GO:0030182,biological_process neuron differentiation;GO:0030855,biological_process epithelial cell differentiation;GO:0030903,biological_process notochord development;GO:0042476,biological_process odontogenesis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0051726,biological_process regulation of cell cycle;GO:0072750,biological_process cellular response to leptomycin B;GO:1901707,molecular_function leptomycin B binding	ID1; DNA-binding protein inhibitor ID1; K04680	inhibitor of DNA binding 3%2C HLH protein [Source:HGNC Symbol%3BAcc:HGNC:5362]
ENSG00000173674	133.24	128.53	117.05	133.28	125.70	133.47	-0.0401514015148795	5.80012693263713	0.580633799313042	0.866170814910803	X:20124517-20141844:-	EIF1AX	7;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding	EIF1A; translation initiation factor 1A; K03236	eukaryotic translation initiation factor 1A%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:3250]
ENSG00000022267	40.69	32.77	42.66	41.51	36.63	43.57	-0.0513932928950767	5.51910442258021	0.580710118591438	0.866180569824023	X:136146701-136211359:+	FHL1	19;GO:0003254,biological_process regulation of membrane depolarization;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0009887,biological_process organ morphogenesis;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0043268,biological_process positive regulation of potassium ion transport;GO:0044325,molecular_function ion channel binding;GO:0046872,molecular_function metal ion binding;GO:1901016,biological_process regulation of potassium ion transmembrane transporter activity;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	FHL1, SLIM1; four and a half LIM domains protein 1; K14365	four and a half LIM domains 1 [Source:HGNC Symbol%3BAcc:HGNC:3702]
ENSG00000197081	88.01	88.10	94.70	91.46	87.62	87.67	0.0336303341980196	9.39456987818891	0.580929018513777	0.86640296849832	6:159969098-160113507:+	IGF2R	53;GO:0001889,biological_process liver development;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0001972,molecular_function retinoic acid binding;GO:0004872,molecular_function receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005010,molecular_function insulin-like growth factor-activated receptor activity;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005537,molecular_function mannose binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005641,cellular_component nuclear envelope lumen;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0009791,biological_process post-embryonic development;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0030118,cellular_component clathrin coat;GO:0030133,cellular_component transport vesicle;GO:0030139,cellular_component endocytic vesicle;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0031100,biological_process organ regeneration;GO:0031995,molecular_function insulin-like growth factor II binding;GO:0032526,biological_process response to retinoic acid;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051219,molecular_function phosphoprotein binding;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	IGF2R, CD222; insulin-like growth factor 2 receptor; K06564	insulin like growth factor 2 receptor [Source:HGNC Symbol%3BAcc:HGNC:5467]
ENSG00000114062	29.59	27.00	29.71	27.78	27.46	29.62	0.0383031181565418	6.26661864291649	0.581010961144837	0.866421078891262	15:25333727-25439056:-	UBE3A	32;GO:0000502,cellular_component proteasome complex;GO:0001541,biological_process ovarian follicle development;GO:0003713,molecular_function transcription coactivator activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007420,biological_process brain development;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0035037,biological_process sperm entry;GO:0042220,biological_process response to cocaine;GO:0042542,biological_process response to hydrogen peroxide;GO:0042752,biological_process regulation of circadian rhythm;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0051865,biological_process protein autoubiquitination;GO:0060736,biological_process prostate gland growth;GO:0061002,biological_process negative regulation of dendritic spine morphogenesis;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1990416,biological_process cellular response to brain-derived neurotrophic factor stimulus;GO:2000058,biological_process regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:2.3.2.26]; K10587	ubiquitin protein ligase E3A [Source:HGNC Symbol%3BAcc:HGNC:12496]
ENSG00000170906	25.44	30.49	27.70	28.98	29.90	28.61	-0.0619853971107455	4.00316874997493	0.581220116346764	0.866628865370856	19:54102727-54109257:+	NDUFA3	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3; K03947	NADH:ubiquinone oxidoreductase subunit A3 [Source:HGNC Symbol%3BAcc:HGNC:7686]
ENSG00000144642	8.08	8.97	7.55	7.51	8.18	8.00	0.0575436556766097	3.79085668952955	0.581360618046398	0.866698768324319	3:28574790-30010391:+	RBMS3	5;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005737,cellular_component cytoplasm;GO:0045727,biological_process positive regulation of translation	NA	RNA binding motif single stranded interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:13427]
ENSG00000177463	11.35	11.34	11.72	10.44	11.23	11.87	0.047808813729039	4.56347259126876	0.581419074786044	0.866698768324319	3:14947583-15053600:+	NR2C2	24;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0007399,biological_process nervous system development;GO:0008270,molecular_function zinc ion binding;GO:0030154,biological_process cell differentiation;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	NA	nuclear receptor subfamily 2 group C member 2 [Source:HGNC Symbol%3BAcc:HGNC:7972]
ENSG00000126461	19.38	19.09	17.84	18.74	18.75	17.85	0.0365577054701405	6.19939217116178	0.581476463595016	0.866698768324319	19:49642124-49658642:+	SCAF1	6;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0019904,molecular_function protein domain specific binding	NA	SR-related CTD associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:30403]
ENSG00000175395	8.36	6.92	9.58	9.41	7.65	9.51	-0.0756485995961129	3.57939461470887	0.581651190231285	0.866853629445746	10:37949571-37976633:-	ZNF25	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 25 [Source:HGNC Symbol%3BAcc:HGNC:13043]
ENSG00000047662	1.84	1.86	1.78	2.17	1.38	1.59	0.104882918988027	2.53076262695142	0.581720030071946	0.866853629445746	4:17629305-17781512:-	FAM184B	NA	NA	family with sequence similarity 184 member B [Source:HGNC Symbol%3BAcc:HGNC:29235]
ENSG00000166377	5.89	5.76	5.33	5.35	5.61	5.59	0.0478660100211313	4.52755542441016	0.581920135877963	0.867047730963047	18:79069284-79378283:+	ATP9B	17;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005524,molecular_function ATP binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006897,biological_process endocytosis;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	ATPase phospholipid transporting 9B (putative) [Source:HGNC Symbol%3BAcc:HGNC:13541]
ENSG00000063245	47.01	51.38	48.29	44.97	50.30	48.65	0.0375887287687341	6.68834943090949	0.582018108993992	0.867089628773695	19:55675225-55709858:+	EPN1	15;GO:0001701,biological_process in utero embryonic development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006897,biological_process endocytosis;GO:0007219,biological_process Notch signaling pathway;GO:0007565,biological_process female pregnancy;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0048568,biological_process embryonic organ development;GO:0061024,biological_process membrane organization	EPN; epsin; K12471	epsin 1 [Source:HGNC Symbol%3BAcc:HGNC:21604]
ENSG00000130957	1.25	0.85	1.23	1.62	1.42	0.90	-0.196133501606858	0.478202333430062	0.582159428058813	0.867152211606901	9:94558719-94593793:-	FBP2	24;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0005986,biological_process sucrose biosynthetic process;GO:0006000,biological_process fructose metabolic process;GO:0006002,biological_process fructose 6-phosphate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0008152,biological_process metabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030388,biological_process fructose 1,6-bisphosphate metabolic process;GO:0042132,molecular_function fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042578,molecular_function phosphoric ester hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	FBP, fbp; fructose-1,6-bisphosphatase I [EC:3.1.3.11]; K03841	fructose-bisphosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:3607]
ENSG00000117632	357.31	424.47	335.38	372.84	424.51	367.65	-0.0497330814278368	7.81348409580677	0.582199833362758	0.867152211606901	1:25884180-25906991:-	STMN1	32;GO:0000281,biological_process mitotic cytokinesis;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007019,biological_process microtubule depolymerization;GO:0007052,biological_process mitotic spindle organization;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0007420,biological_process brain development;GO:0009615,biological_process response to virus;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0031110,biological_process regulation of microtubule polymerization or depolymerization;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0031175,biological_process neuron projection development;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043005,cellular_component neuron projection;GO:0048012,biological_process hepatocyte growth factor receptor signaling pathway;GO:0051272,biological_process positive regulation of cellular component movement;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0061436,biological_process establishment of skin barrier;GO:0070062,cellular_component extracellular exosome;GO:0070495,biological_process negative regulation of thrombin receptor signaling pathway;GO:1905098,biological_process negative regulation of guanyl-nucleotide exchange factor activity	STMN1; stathmin; K04381	stathmin 1 [Source:HGNC Symbol%3BAcc:HGNC:6510]
ENSG00000196670	8.76	9.10	9.65	8.18	9.52	9.09	0.0497980467291214	4.62032697159308	0.582396089506318	0.867266024710745	5:180847610-180861285:-	ZFP62	5;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	ZFP62 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:23241]
ENSG00000204599	2.90	2.85	2.38	2.42	2.59	2.62	0.0968054596438224	2.1281147032517	0.582415981792377	0.867266024710745	6:30326478-30343729:+	TRIM39	13;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	tripartite motif containing 39 [Source:HGNC Symbol%3BAcc:HGNC:10065]
ENSG00000151150	0.15	0.20	0.10	0.13	0.18	0.19	-0.171265538158941	1.28297553420358	0.582659438221526	0.86747311942736	10:60026297-60733490:-	ANK3	64;GO:0000281,biological_process mitotic cytokinesis;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007009,biological_process plasma membrane organization;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007165,biological_process signal transduction;GO:0007409,biological_process axonogenesis;GO:0007528,biological_process neuromuscular junction development;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009925,cellular_component basal plasma membrane;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010650,biological_process positive regulation of cell communication by electrical coupling;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0010960,biological_process magnesium ion homeostasis;GO:0014704,cellular_component intercalated disc;GO:0014731,cellular_component spectrin-associated cytoskeleton;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0019228,biological_process neuronal action potential;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030315,cellular_component T-tubule;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030507,molecular_function spectrin binding;GO:0030674,molecular_function protein binding, bridging;GO:0031594,cellular_component neuromuscular junction;GO:0033268,cellular_component node of Ranvier;GO:0034112,biological_process positive regulation of homotypic cell-cell adhesion;GO:0042383,cellular_component sarcolemma;GO:0042995,cellular_component cell projection;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043005,cellular_component neuron projection;GO:0043034,cellular_component costamere;GO:0043194,cellular_component axon initial segment;GO:0043266,biological_process regulation of potassium ion transport;GO:0044325,molecular_function ion channel binding;GO:0045184,biological_process establishment of protein localization;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045296,molecular_function cadherin binding;GO:0045838,biological_process positive regulation of membrane potential;GO:0071286,biological_process cellular response to magnesium ion;GO:0071709,biological_process membrane assembly;GO:0072659,biological_process protein localization to plasma membrane;GO:0072660,biological_process maintenance of protein location in plasma membrane;GO:0072661,biological_process protein targeting to plasma membrane;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1900827,biological_process positive regulation of membrane depolarization during cardiac muscle cell action potential;GO:1902260,biological_process negative regulation of delayed rectifier potassium channel activity;GO:2000651,biological_process positive regulation of sodium ion transmembrane transporter activity;GO:2001259,biological_process positive regulation of cation channel activity	ANK; ankyrin; K10380	ankyrin 3 [Source:HGNC Symbol%3BAcc:HGNC:494]
ENSG00000165637	125.70	126.99	105.72	119.11	109.81	121.55	0.0427684844480831	6.82469317706666	0.58275207580942	0.86747311942736	10:75210153-75231448:+	VDAC2	23;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0008021,cellular_component synaptic vesicle;GO:0008308,molecular_function voltage-gated anion channel activity;GO:0015288,molecular_function porin activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032272,biological_process negative regulation of protein polymerization;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043209,cellular_component myelin sheath;GO:0046930,cellular_component pore complex;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0098656,biological_process anion transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	VDAC2; voltage-dependent anion channel protein 2; K15040	voltage dependent anion channel 2 [Source:HGNC Symbol%3BAcc:HGNC:12672]
ENSG00000124207	65.19	68.57	60.03	63.36	63.24	63.85	0.0358657927813473	7.54505502060153	0.582764709812677	0.86747311942736	20:49046245-49096960:+	CSE1L	17;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006915,biological_process apoptotic process;GO:0008283,biological_process cell proliferation;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	NA	chromosome segregation 1 like [Source:HGNC Symbol%3BAcc:HGNC:2431]
ENSG00000138193	3.96	4.45	3.90	3.87	5.05	3.99	-0.0603775765006785	4.9233075992528	0.582897025957536	0.867566041152386	10:94030811-94332823:+	PLCE1	43;GO:0000139,cellular_component Golgi membrane;GO:0000187,biological_process activation of MAPK activity;GO:0001558,biological_process regulation of cell growth;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006651,biological_process diacylglycerol biosynthetic process;GO:0006940,biological_process regulation of smooth muscle contraction;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0007507,biological_process heart development;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0017016,molecular_function Ras GTPase binding;GO:0019722,biological_process calcium-mediated signaling;GO:0019899,molecular_function enzyme binding;GO:0032835,biological_process glomerulus development;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0045859,biological_process regulation of protein kinase activity;GO:0046578,biological_process regulation of Ras protein signal transduction;GO:0046872,molecular_function metal ion binding;GO:0048016,biological_process inositol phosphate-mediated signaling	PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]; K05860	phospholipase C epsilon 1 [Source:HGNC Symbol%3BAcc:HGNC:17175]
ENSG00000182179	18.01	16.65	18.59	17.53	16.64	18.14	0.0402579545243494	5.74538102766892	0.583146991307793	0.867661056177193	3:49805206-49813946:-	UBA7	19;GO:0000166,molecular_function nucleotide binding;GO:0004839,molecular_function ubiquitin activating enzyme activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008641,molecular_function small protein activating enzyme activity;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0019782,molecular_function ISG15 activating enzyme activity;GO:0019941,biological_process modification-dependent protein catabolic process;GO:0019985,biological_process translesion synthesis;GO:0032020,biological_process ISG15-protein conjugation;GO:0032480,biological_process negative regulation of type I interferon production	UBE1L, UBA7; ubiquitin-activating enzyme E1-like [EC:6.2.1.45]; K10698	ubiquitin like modifier activating enzyme 7 [Source:HGNC Symbol%3BAcc:HGNC:12471]
ENSG00000166579	20.45	22.65	24.36	21.14	22.86	21.84	0.0458188596041531	5.08681060819165	0.58317108972925	0.867661056177193	17:8413130-8490411:+	NDEL1	61;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001764,biological_process neuron migration;GO:0001833,biological_process inner cell mass cell proliferation;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0007020,biological_process microtubule nucleation;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007100,biological_process mitotic centrosome separation;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008017,molecular_function microtubule binding;GO:0008021,cellular_component synaptic vesicle;GO:0008090,biological_process retrograde axonal transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010975,biological_process regulation of neuron projection development;GO:0016477,biological_process cell migration;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0021955,biological_process central nervous system neuron axonogenesis;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0031175,biological_process neuron projection development;GO:0031252,cellular_component cell leading edge;GO:0032403,molecular_function protein complex binding;GO:0033157,biological_process regulation of intracellular protein transport;GO:0042802,molecular_function identical protein binding;GO:0043014,molecular_function alpha-tubulin binding;GO:0043203,cellular_component axon hillock;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044297,cellular_component cell body;GO:0045773,biological_process positive regulation of axon extension;GO:0047496,biological_process vesicle transport along microtubule;GO:0048487,molecular_function beta-tubulin binding;GO:0048680,biological_process positive regulation of axon regeneration;GO:0051081,biological_process nuclear envelope disassembly;GO:0051303,biological_process establishment of chromosome localization;GO:0051642,biological_process centrosome localization;GO:0060052,biological_process neurofilament cytoskeleton organization;GO:0060053,cellular_component neurofilament cytoskeleton;GO:0070012,molecular_function oligopeptidase activity;GO:0090630,biological_process activation of GTPase activity;GO:0090724,cellular_component central region of growth cone;GO:1904115,cellular_component axon cytoplasm;GO:1990138,biological_process neuron projection extension;GO:2000574,biological_process regulation of microtubule motor activity	NA	nudE neurodevelopment protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:17620]
ENSG00000163157	1.47	1.44	0.90	0.99	1.36	1.00	0.191907298204873	0.492150704144492	0.583226456076592	0.867661056177193	1:151169985-151176284:-	TMOD4	10;GO:0003779,molecular_function actin binding;GO:0005523,molecular_function tropomyosin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005865,cellular_component striated muscle thin filament;GO:0006936,biological_process muscle contraction;GO:0007015,biological_process actin filament organization;GO:0030239,biological_process myofibril assembly;GO:0051015,molecular_function actin filament binding;GO:0051694,biological_process pointed-end actin filament capping	NA	tropomodulin 4 [Source:HGNC Symbol%3BAcc:HGNC:11874]
ENSG00000162692	247.46	220.10	246.40	239.61	207.24	251.87	0.043234574329836	9.02942289474208	0.583240461833763	0.867661056177193	1:100719741-100739045:+	VCAM1	48;GO:0001666,biological_process response to hypoxia;GO:0002102,cellular_component podosome;GO:0002526,biological_process acute inflammatory response;GO:0002544,biological_process chronic inflammatory response;GO:0005178,molecular_function integrin binding;GO:0005615,cellular_component extracellular space;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0008131,molecular_function primary amine oxidase activity;GO:0009308,biological_process amine metabolic process;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010043,biological_process response to zinc ion;GO:0010212,biological_process response to ionizing radiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0022614,biological_process membrane to membrane docking;GO:0030175,cellular_component filopodium;GO:0030183,biological_process B cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0032496,biological_process response to lipopolysaccharide;GO:0035094,biological_process response to nicotine;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042383,cellular_component sarcolemma;GO:0045177,cellular_component apical part of cell;GO:0045471,biological_process response to ethanol;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050901,biological_process leukocyte tethering or rolling;GO:0055114,biological_process oxidation-reduction process;GO:0060326,biological_process cell chemotaxis;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071065,cellular_component alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;GO:0071356,biological_process cellular response to tumor necrosis factor	VCAM1, CD106; vascular cell adhesion molecule 1; K06527	vascular cell adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:12663]
ENSG00000177599	0.59	0.95	0.67	0.80	0.40	0.64	0.234187571878041	0.0377591927760276	0.583328280577271	0.86768771082153	19:11797666-11809622:+	ZNF491	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 491 [Source:HGNC Symbol%3BAcc:HGNC:23706]
ENSG00000186652	2.86	0.86	2.76	1.91	2.28	1.58	0.233857855030761	0.626511079537733	0.583403822768524	0.867696100170823	11:57386793-57390657:-	PRG2	15;GO:0002215,biological_process defense response to nematode;GO:0002376,biological_process immune system process;GO:0005576,cellular_component extracellular region;GO:0006955,biological_process immune response;GO:0008201,molecular_function heparin binding;GO:0030133,cellular_component transport vesicle;GO:0030246,molecular_function carbohydrate binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032693,biological_process negative regulation of interleukin-10 production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0042035,biological_process regulation of cytokine biosynthetic process;GO:0042742,biological_process defense response to bacterium;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	PRG2, MBP; bone marrow proteoglycan; K10786	proteoglycan 2%2C pro eosinophil major basic protein [Source:HGNC Symbol%3BAcc:HGNC:9362]
ENSG00000143033	15.56	18.48	17.50	17.17	19.57	17.00	-0.0525247631584752	4.9695211313324	0.583595258214811	0.867805861598203	1:93079234-93139081:+	MTF2	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007379,biological_process segment specification;GO:0016569,biological_process covalent chromatin modification;GO:0019827,biological_process stem cell population maintenance;GO:0035064,molecular_function methylated histone binding;GO:0035098,cellular_component ESC/E(Z) complex;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048863,biological_process stem cell differentiation;GO:0061086,biological_process negative regulation of histone H3-K27 methylation;GO:0061087,biological_process positive regulation of histone H3-K27 methylation;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	metal response element binding transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:29535]
ENSG00000074582	17.59	19.77	18.74	20.61	19.25	18.57	-0.0514917692613632	4.59247123087391	0.583617444020124	0.867805861598203	2:218658763-218663443:+	BCS1L	12;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0007005,biological_process mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly	NA	BCS1 homolog%2C ubiquinol-cytochrome c reductase complex chaperone [Source:HGNC Symbol%3BAcc:HGNC:1020]
ENSG00000111269	50.81	54.15	52.95	47.00	46.98	58.60	0.0566327554528597	4.23158881149309	0.58369324822218	0.86781462332997	12:12611826-12645108:+	CREBL2	14;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0030154,biological_process cell differentiation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046326,biological_process positive regulation of glucose import;GO:0046889,biological_process positive regulation of lipid biosynthetic process;GO:0050821,biological_process protein stabilization	NA	cAMP responsive element binding protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:2350]
ENSG00000063046	228.06	215.46	225.33	216.09	222.03	221.65	0.0317927769880781	8.74318808233495	0.584160368288455	0.868405107971807	12:53006157-53042209:+	EIF4B	19;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex;GO:0030425,cellular_component dendrite;GO:0033592,molecular_function RNA strand annealing activity;GO:0034057,molecular_function RNA strand-exchange activity;GO:0043024,molecular_function ribosomal small subunit binding;GO:0043025,cellular_component neuronal cell body;GO:0097010,biological_process eukaryotic translation initiation factor 4F complex assembly	EIF4B; translation initiation factor 4B; K03258	eukaryotic translation initiation factor 4B [Source:HGNC Symbol%3BAcc:HGNC:3285]
ENSG00000086061	198.06	205.33	191.39	192.81	199.51	193.54	0.0330502495469411	7.87421307459794	0.584247069680614	0.868429993527177	9:33025210-33039907:+	DNAJA1	42;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006986,biological_process response to unfolded protein;GO:0007283,biological_process spermatogenesis;GO:0009408,biological_process response to heat;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0030317,biological_process sperm motility;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030544,molecular_function Hsp70 protein binding;GO:0030957,molecular_function Tat protein binding;GO:0031072,molecular_function heat shock protein binding;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043508,biological_process negative regulation of JUN kinase activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051223,biological_process regulation of protein transport;GO:0055131,molecular_function C3HC4-type RING finger domain binding;GO:0070062,cellular_component extracellular exosome;GO:0070585,biological_process protein localization to mitochondrion;GO:0098554,cellular_component cytoplasmic side of endoplasmic reticulum membrane;GO:1901998,biological_process toxin transport;GO:1903748,biological_process negative regulation of establishment of protein localization to mitochondrion;GO:1905259,biological_process negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	NA	DnaJ heat shock protein family (Hsp40) member A1 [Source:HGNC Symbol%3BAcc:HGNC:5229]
ENSG00000162585	31.76	31.21	33.49	29.58	29.64	34.86	0.0478140290751699	4.89979190641927	0.584405458634864	0.868519543591264	1:2184460-2212720:-	FAAP20	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016604,cellular_component nuclear body;GO:0019985,biological_process translesion synthesis;GO:0030054,cellular_component cell junction;GO:0031593,molecular_function polyubiquitin binding;GO:0036297,biological_process interstrand cross-link repair;GO:0043130,molecular_function ubiquitin binding;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0046872,molecular_function metal ion binding;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0140036,Molecular_Function ubiquitin-dependent protein binding	NA	Fanconi anemia core complex associated protein 20 [Source:HGNC Symbol%3BAcc:HGNC:26428]
ENSG00000128973	8.86	10.80	9.11	10.25	11.64	8.59	-0.0779778783063122	3.59367141355422	0.584447252688136	0.868519543591264	15:68206991-68257211:-	CLN6	17;GO:0001573,biological_process ganglioside metabolic process;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007040,biological_process lysosome organization;GO:0007042,biological_process lysosomal lumen acidification;GO:0007601,biological_process visual perception;GO:0008203,biological_process cholesterol metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030163,biological_process protein catabolic process;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0031987,biological_process locomotion involved in locomotory behavior;GO:0042803,molecular_function protein homodimerization activity;GO:0044265,biological_process cellular macromolecule catabolic process;GO:0045862,biological_process positive regulation of proteolysis	NA	CLN6%2C transmembrane ER protein [Source:HGNC Symbol%3BAcc:HGNC:2077]
ENSG00000153214	19.30	17.33	18.30	19.83	16.94	20.57	-0.0479034449277485	4.97193581957787	0.584539034111977	0.868551954803923	2:112055222-112119318:+	TMEM87B	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi	NA	transmembrane protein 87B [Source:HGNC Symbol%3BAcc:HGNC:25913]
ENSG00000163637	4.95	5.02	5.11	5.11	5.01	4.47	0.0605675027853423	3.76702182265657	0.584727219959217	0.868727586038751	3:64092241-64445476:-	PRICKLE2	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0031965,cellular_component nuclear membrane;GO:0046872,molecular_function metal ion binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway	PRICKLE; prickle; K04511	prickle planar cell polarity protein 2 [Source:HGNC Symbol%3BAcc:HGNC:20340]
ENSG00000181061	40.03	31.76	24.68	38.21	30.61	34.85	-0.0903034211227396	3.51421909013568	0.584804618912472	0.86873754480845	3:42784297-42804531:-	HIGD1A	11;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0055114,biological_process oxidation-reduction process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070469,cellular_component respiratory chain	NA	HIG1 hypoxia inducible domain family member 1A [Source:HGNC Symbol%3BAcc:HGNC:29527]
ENSG00000166704	4.92	4.18	4.65	4.49	5.35	4.71	-0.0609193058801238	3.62923311140988	0.584909246042799	0.86873754480845	19:57977052-58003349:-	ZNF606	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 606 [Source:HGNC Symbol%3BAcc:HGNC:25879]
ENSG00000137824	15.91	12.51	14.41	16.26	13.89	14.87	-0.0523252957175526	4.55507838770238	0.585073963776891	0.86873754480845	15:40735883-40755851:-	RMDN3	15;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0031966,cellular_component mitochondrial membrane	NA	regulator of microtubule dynamics 3 [Source:HGNC Symbol%3BAcc:HGNC:25550]
ENSG00000171488	1.50	1.37	1.51	1.13	1.40	1.55	0.114655307468953	1.85153816293355	0.585075343339784	0.86873754480845	1:89633071-89769903:+	LRRC8C	17;GO:0005225,molecular_function volume-sensitive anion channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034702,cellular_component ion channel complex;GO:0044070,biological_process regulation of anion transport;GO:0045444,biological_process fat cell differentiation;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	leucine rich repeat containing 8 family member C [Source:HGNC Symbol%3BAcc:HGNC:25075]
ENSG00000100426	8.60	8.68	9.72	9.85	9.37	8.91	-0.0444837694419863	5.02089398187745	0.58511974596364	0.86873754480845	22:49853841-49890078:+	ZBED4	11;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity	NA	zinc finger BED-type containing 4 [Source:HGNC Symbol%3BAcc:HGNC:20721]
ENSG00000119953	43.03	42.56	43.60	45.82	46.74	41.76	-0.0424960879020843	4.97877098106713	0.585153839695759	0.86873754480845	10:110290729-110304951:-	SMNDC1	13;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck	SMNDC1, SPF30; survival of motor neuron-related-splicing factor 30; K12839	survival motor neuron domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16900]
ENSG00000141642	4.11	2.36	5.07	4.49	4.28	4.03	-0.11365461700453	2.26786425427771	0.585468748833254	0.869043630086423	18:50967990-50988121:+	ELAC1	13;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0016891,molecular_function endoribonuclease activity, producing 5'-phosphomonoesters;GO:0034414,biological_process tRNA 3'-trailer cleavage, endonucleolytic;GO:0042779,biological_process tRNA 3'-trailer cleavage;GO:0042781,molecular_function 3'-tRNA processing endoribonuclease activity;GO:0046872,molecular_function metal ion binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	rnz; ribonuclease Z [EC:3.1.26.11]; K00784	elaC ribonuclease Z 1 [Source:HGNC Symbol%3BAcc:HGNC:14197]
ENSG00000155846	0.32	0.46	0.31	0.36	0.37	0.51	-0.202683574036227	0.517690240608111	0.585500030485197	0.869043630086423	5:149730297-149855022:+	PPARGC1B	32;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001503,biological_process ossification;GO:0003676,molecular_function nucleic acid binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0007015,biological_process actin filament organization;GO:0008134,molecular_function transcription factor binding;GO:0010694,biological_process positive regulation of alkaline phosphatase activity;GO:0016592,cellular_component mediator complex;GO:0030331,molecular_function estrogen receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0030546,molecular_function receptor activator activity;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0042327,biological_process positive regulation of phosphorylation;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045780,biological_process positive regulation of bone resorption;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050682,molecular_function AF-2 domain binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051384,biological_process response to glucocorticoid;GO:0051591,biological_process response to cAMP;GO:0060346,biological_process bone trabecula formation;GO:1903506,biological_process regulation of nucleic acid-templated transcription;GO:2000273,biological_process positive regulation of receptor activity	NA	PPARG coactivator 1 beta [Source:HGNC Symbol%3BAcc:HGNC:30022]
ENSG00000108669	15.79	12.11	10.97	13.57	14.27	13.34	-0.0666942323371711	4.135640906262	0.585647322584363	0.869121485366722	17:78674047-78782297:-	CYTH1	16;GO:0000139,cellular_component Golgi membrane;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030155,biological_process regulation of cell adhesion;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0090162,biological_process establishment of epithelial cell polarity	NA	cytohesin 1 [Source:HGNC Symbol%3BAcc:HGNC:9501]
ENSG00000084112	5.45	4.54	4.93	5.66	5.08	4.97	-0.0539151141527344	4.19085297737642	0.585692517932219	0.869121485366722	12:108778191-108857590:-	SSH1	35;GO:0000902,biological_process cell morphogenesis;GO:0003779,molecular_function actin binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0008064,biological_process regulation of actin polymerization or depolymerization;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0031252,cellular_component cell leading edge;GO:0031915,biological_process positive regulation of synaptic plasticity;GO:0032154,cellular_component cleavage furrow;GO:0032268,biological_process regulation of cellular protein metabolic process;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042995,cellular_component cell projection;GO:0050770,biological_process regulation of axonogenesis;GO:0071318,biological_process cellular response to ATP;GO:0098976,biological_process excitatory chemical synaptic transmission;GO:1901216,biological_process positive regulation of neuron death;GO:1904719,biological_process positive regulation of AMPA glutamate receptor clustering;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential	SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]; K05766	slingshot protein phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:30579]
ENSG00000181284	3.89	5.77	4.73	4.23	4.98	4.34	0.0844828800631066	2.8453182467697	0.585978351875088	0.869311806766169	17:7435442-7437679:+	TMEM102	17;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0010820,biological_process positive regulation of T cell chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034097,biological_process response to cytokine;GO:0042981,biological_process regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045785,biological_process positive regulation of cell adhesion;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:1901028,biological_process regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:2000406,biological_process positive regulation of T cell migration	NA	transmembrane protein 102 [Source:HGNC Symbol%3BAcc:HGNC:26722]
ENSG00000119541	32.07	35.41	35.22	32.67	38.71	35.32	-0.0449414335925484	5.56495605709222	0.585978786787718	0.869311806766169	18:63389189-63422483:-	VPS4B	54;GO:0000166,molecular_function nucleotide binding;GO:0000920,biological_process cell separation after cytokinesis;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006813,biological_process potassium ion transport;GO:0006997,biological_process nucleus organization;GO:0007032,biological_process endosome organization;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008022,molecular_function protein C-terminus binding;GO:0010008,cellular_component endosome membrane;GO:0010824,biological_process regulation of centrosome duplication;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0019058,biological_process viral life cycle;GO:0019076,biological_process viral release from host cell;GO:0030301,biological_process cholesterol transport;GO:0031902,cellular_component late endosome membrane;GO:0032510,biological_process endosome to lysosome transport via multivesicular body sorting pathway;GO:0033993,biological_process response to lipid;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042623,molecular_function ATPase activity, coupled;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0048524,biological_process positive regulation of viral process;GO:0050792,biological_process regulation of viral process;GO:0051261,biological_process protein depolymerization;GO:0051301,biological_process cell division;GO:0060548,biological_process negative regulation of cell death;GO:0061738,biological_process late endosomal microautophagy;GO:0070062,cellular_component extracellular exosome;GO:0090543,cellular_component Flemming body;GO:0090611,biological_process ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1902188,biological_process positive regulation of viral release from host cell;GO:1903542,biological_process negative regulation of exosomal secretion;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903724,biological_process positive regulation of centriole elongation;GO:1903902,biological_process positive regulation of viral life cycle;GO:1904903,biological_process ESCRT III complex disassembly	VPS4; vacuolar protein-sorting-associated protein 4; K12196	vacuolar protein sorting 4 homolog B [Source:HGNC Symbol%3BAcc:HGNC:10895]
ENSG00000151239	53.26	56.60	59.74	56.18	61.17	58.23	-0.0384028672670302	6.51124243691981	0.586030870782188	0.869311806766169	12:43793722-43806375:-	TWF1	22;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005524,molecular_function ATP binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0015629,cellular_component actin cytoskeleton;GO:0030016,cellular_component myofibril;GO:0030175,cellular_component filopodium;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0032403,molecular_function protein complex binding;GO:0032587,cellular_component ruffle membrane;GO:0042989,biological_process sequestering of actin monomers;GO:0043538,biological_process regulation of actin phosphorylation;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051016,biological_process barbed-end actin filament capping	NA	twinfilin actin binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9620]
ENSG00000144635	28.23	29.17	29.83	30.65	30.70	28.90	-0.0372720456074645	5.70629398791125	0.586103046866795	0.869314986349328	3:32525970-32570874:-	DYNC1LI1	35;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0003723,molecular_function RNA binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019003,molecular_function GDP binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030286,cellular_component dynein complex;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0045504,molecular_function dynein heavy chain binding;GO:0051301,biological_process cell division;GO:0090267,biological_process positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0101003,cellular_component ficolin-1-rich granule membrane	DYNC1LI, DNCLI; dynein light intermediate chain 1, cytosolic; K10416	dynein cytoplasmic 1 light intermediate chain 1 [Source:HGNC Symbol%3BAcc:HGNC:18745]
ENSG00000061676	94.29	95.65	96.47	94.50	93.45	94.67	0.030915767383893	8.33543546058482	0.586423273351227	0.86968603251001	2:182909114-183038858:-	NCKAP1	24;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006915,biological_process apoptotic process;GO:0007417,biological_process central nervous system development;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016601,biological_process Rac protein signal transduction;GO:0030027,cellular_component lamellipodium;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031209,cellular_component SCAR complex;GO:0031258,cellular_component lamellipodium membrane;GO:0031941,cellular_component filamentous actin;GO:0032403,molecular_function protein complex binding;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0070062,cellular_component extracellular exosome;GO:2000601,biological_process positive regulation of Arp2/3 complex-mediated actin nucleation	NCKAP1, NAP125; NCK-associated protein 1; K05750	NCK associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7666]
ENSG00000213965	9.73	9.60	10.86	11.38	9.64	10.88	-0.0650825205588785	3.56342702224672	0.586763733627828	0.870015202182163	19:32691960-32713796:+	NUDT19	10;GO:0005102,molecular_function receptor binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0008150,biological_process biological_process;GO:0009062,biological_process fatty acid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0047617,molecular_function acyl-CoA hydrolase activity	NUDT19; nucleoside diphosphate-linked moiety X motif 19, mitochondrial [EC:3.6.1.-]; K13355	nudix hydrolase 19 [Source:HGNC Symbol%3BAcc:HGNC:32036]
ENSG00000169696	6.85	7.21	6.85	8.04	6.59	7.25	-0.0571348869008195	4.22421692674684	0.586805415055812	0.870015202182163	17:81976806-82017406:+	ASPSCR1	21;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0008150,biological_process biological_process;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0012505,cellular_component endomembrane system;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0019898,cellular_component extrinsic component of membrane;GO:0031401,biological_process positive regulation of protein modification process;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042593,biological_process glucose homeostasis;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046324,biological_process regulation of glucose import;GO:0048471,cellular_component perinuclear region of cytoplasm	ASPSCR1, ASPL; tether containing UBX domain for GLUT4; K15627	ASPSCR1%2C UBX domain containing tether for SLC2A4 [Source:HGNC Symbol%3BAcc:HGNC:13825]
ENSG00000104723	85.66	87.47	81.85	81.64	85.13	84.02	0.0345089012618083	6.48699278614749	0.586908452713119	0.870015202182163	8:15417214-15766649:+	TUSC3	18;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006810,biological_process transport;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0050890,biological_process cognition;GO:0055085,biological_process transmembrane transport;GO:1903830,biological_process magnesium ion transmembrane transport	OST3, OST6; oligosaccharyltransferase complex subunit gamma; K12669	tumor suppressor candidate 3 [Source:HGNC Symbol%3BAcc:HGNC:30242]
ENSG00000172977	24.28	27.04	26.03	25.52	25.19	25.07	0.0376172963047228	5.46450428790908	0.586925586326708	0.870015202182163	11:65711995-65719604:+	KAT5	44;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000812,cellular_component Swr1 complex;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0010212,biological_process response to ionizing radiation;GO:0016032,biological_process viral process;GO:0016407,molecular_function acetyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0030521,biological_process androgen receptor signaling pathway;GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0032777,cellular_component Piccolo NuA4 histone acetyltransferase complex;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050681,molecular_function androgen receptor binding;GO:0070491,molecular_function repressing transcription factor binding;GO:0071392,biological_process cellular response to estradiol stimulus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1901985,biological_process positive regulation of protein acetylation;GO:1904837,biological_process beta-catenin-TCF complex assembly	TIP60, KAT5, ESA1; histone acetyltransferase HTATIP [EC:2.3.1.48]; K11304	lysine acetyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:5275]
ENSG00000138614	24.24	22.88	22.24	26.06	22.18	23.83	-0.042862187860214	5.45317123602707	0.587170663632982	0.870143207088748	15:65578752-65611289:-	INTS14	6;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 14 [Source:HGNC Symbol%3BAcc:HGNC:25372]
ENSG00000197903	45.40	39.44	44.98	42.78	44.14	39.25	0.0617740566222948	4.02820670575102	0.587189250319712	0.870143207088748	6:27146417-27146798:-	HIST1H2BK	18;GO:0000786,cellular_component nucleosome;GO:0002227,biological_process innate immune response in mucosa;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006334,biological_process nucleosome assembly;GO:0016567,biological_process protein ubiquitination;GO:0019731,biological_process antibacterial humoral response;GO:0031640,biological_process killing of cells of other organism;GO:0042742,biological_process defense response to bacterium;GO:0046982,molecular_function protein heterodimerization activity;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide	NA	histone cluster 1 H2B family member k [Source:HGNC Symbol%3BAcc:HGNC:13954]
ENSG00000005448	40.63	35.79	37.07	35.77	37.57	38.03	0.0426219006084045	5.34131995055538	0.587222238442153	0.870143207088748	2:74421677-74425755:+	WDR54	NA	NA	WD repeat domain 54 [Source:HGNC Symbol%3BAcc:HGNC:25770]
ENSG00000149177	27.35	24.89	26.75	26.32	24.99	26.41	0.0366117630327816	6.72473472565347	0.587345078339409	0.870221348463485	11:47980557-48170841:+	PTPRJ	44;GO:0001772,cellular_component immunological synapse;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006470,biological_process protein dephosphorylation;GO:0008013,molecular_function beta-catenin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010642,biological_process negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030155,biological_process regulation of cell adhesion;GO:0030308,biological_process negative regulation of cell growth;GO:0030336,biological_process negative regulation of cell migration;GO:0032587,cellular_component ruffle membrane;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035579,cellular_component specific granule membrane;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042995,cellular_component cell projection;GO:0043116,biological_process negative regulation of vascular permeability;GO:0043312,biological_process neutrophil degranulation;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0045295,molecular_function gamma-catenin binding;GO:0045785,biological_process positive regulation of cell adhesion;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0050918,biological_process positive chemotaxis;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060242,biological_process contact inhibition;GO:0070062,cellular_component extracellular exosome;GO:0070097,molecular_function delta-catenin binding	PTPRJ, DEP1, CD148; receptor-type tyrosine-protein phosphatase eta [EC:3.1.3.48]; K05698	protein tyrosine phosphatase%2C receptor type J [Source:HGNC Symbol%3BAcc:HGNC:9673]
ENSG00000197410	0.23	0.24	0.23	0.23	0.21	0.20	0.134878280492853	1.35585582785205	0.587529963140952	0.870391387094957	4:154232036-154491716:-	DCHS2	11;GO:0003674,molecular_function molecular_function;GO:0005509,molecular_function calcium ion binding;GO:0005575,cellular_component cellular_component;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0072006,biological_process nephron development;GO:0072137,biological_process condensed mesenchymal cell proliferation	DCHS1_2, PCDH16_23; protocadherin-16/23; K16507	dachsous cadherin-related 2 [Source:HGNC Symbol%3BAcc:HGNC:23111]
ENSG00000103540	9.71	8.29	8.52	8.49	9.32	9.90	-0.0481692312679813	4.8050646371804	0.587612680655754	0.870410048326954	16:19523810-19553408:+	CCP110	21;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007099,biological_process centriole replication;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0030030,biological_process cell projection organization;GO:0032053,biological_process ciliary basal body organization;GO:0032465,biological_process regulation of cytokinesis;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0045724,biological_process positive regulation of cilium assembly;GO:0051298,biological_process centrosome duplication;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1902018,biological_process negative regulation of cilium assembly	NA	centriolar coiled-coil protein 110 [Source:HGNC Symbol%3BAcc:HGNC:24342]
ENSG00000147123	97.20	98.30	92.72	98.76	101.28	97.93	-0.0374420559316423	5.58324655827649	0.587738175739596	0.870492062457417	X:47142215-47145504:-	NDUFB11	10;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11; K11351	NADH:ubiquinone oxidoreductase subunit B11 [Source:HGNC Symbol%3BAcc:HGNC:20372]
ENSG00000149428	64.47	62.51	62.64	64.83	60.80	61.18	0.0334199724867708	7.57799584354744	0.587991837134622	0.870763859979964	11:119044188-119057202:-	HYOU1	21;GO:0000166,molecular_function nucleotide binding;GO:0002931,biological_process response to ischemia;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005925,cellular_component focal adhesion;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0016020,cellular_component membrane;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043066,biological_process negative regulation of apoptotic process;GO:0051087,molecular_function chaperone binding;GO:0070062,cellular_component extracellular exosome;GO:0071456,biological_process cellular response to hypoxia;GO:0071682,cellular_component endocytic vesicle lumen;GO:1903298,biological_process negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:1903382,biological_process negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	HYOU1; hypoxia up-regulated 1; K09486	hypoxia up-regulated 1 [Source:HGNC Symbol%3BAcc:HGNC:16931]
ENSG00000223496	7.36	8.08	7.76	9.27	7.71	7.84	-0.0903938052873205	2.7394027971811	0.588233661875509	0.870826455530739	16:70246777-70251930:-	EXOSC6	21;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0016075,biological_process rRNA catabolic process;GO:0031125,biological_process rRNA 3'-end processing;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045006,biological_process DNA deamination;GO:0045190,biological_process isotype switching;GO:0045830,biological_process positive regulation of isotype switching;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071051,biological_process polyadenylation-dependent snoRNA 3'-end processing	MTR3, EXOSC6; exosome complex component MTR3; K12587	exosome component 6 [Source:HGNC Symbol%3BAcc:HGNC:19055]
ENSG00000188868	3.31	2.34	2.89	2.94	2.71	3.69	-0.103479141170969	2.15434871181789	0.588246528193946	0.870826455530739	19:12317476-12333720:-	ZNF563	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 563 [Source:HGNC Symbol%3BAcc:HGNC:30498]
ENSG00000141627	16.43	17.93	17.03	18.38	15.84	19.17	-0.0471879807232639	5.39419110286553	0.588256001446254	0.870826455530739	18:49041473-49461347:-	DYM	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0019899,molecular_function enzyme binding;GO:0060348,biological_process bone development	NA	dymeclin [Source:HGNC Symbol%3BAcc:HGNC:21317]
ENSG00000177409	9.97	7.76	10.50	8.74	9.02	9.72	0.0562458514387297	5.47370324382083	0.588314722958251	0.870826455530739	7:93130054-93148369:-	SAMD9L	4;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0034058,biological_process endosomal vesicle fusion	NA	sterile alpha motif domain containing 9 like [Source:HGNC Symbol%3BAcc:HGNC:1349]
ENSG00000105483	11.09	12.79	9.77	10.99	10.48	11.00	0.0540426142922044	4.35833100170749	0.588445272423682	0.870915841969139	19:48180769-48255946:-	CARD8	22;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0031665,biological_process negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032089,molecular_function NACHT domain binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0050700,molecular_function CARD domain binding;GO:0050713,biological_process negative regulation of interleukin-1 beta secretion;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0072559,cellular_component NLRP3 inflammasome complex;GO:0097340,biological_process inhibition of cysteine-type endopeptidase activity	CARD8, CARDINAL; caspase recruitment domain-containing protein 8; K12801	caspase recruitment domain family member 8 [Source:HGNC Symbol%3BAcc:HGNC:17057]
ENSG00000005801	9.31	10.02	8.46	10.76	9.39	8.92	-0.0571445383391822	4.49478264083706	0.588608518586083	0.871032754808089	11:3339260-3379222:-	ZNF195	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 195 [Source:HGNC Symbol%3BAcc:HGNC:12986]
ENSG00000118804	19.99	22.25	21.31	22.73	21.61	21.74	-0.0490776489093853	4.54492191257416	0.588664608079035	0.871032754808089	4:76306025-76311599:+	STBD1	26;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005980,biological_process glycogen catabolic process;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0030246,molecular_function carbohydrate binding;GO:0030247,molecular_function polysaccharide binding;GO:0030315,cellular_component T-tubule;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0043312,biological_process neutrophil degranulation;GO:0046907,biological_process intracellular transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061723,biological_process glycophagy;GO:0070821,cellular_component tertiary granule membrane;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:2001069,molecular_function glycogen binding;GO:2001070,molecular_function starch binding	NA	starch binding domain 1 [Source:HGNC Symbol%3BAcc:HGNC:24854]
ENSG00000152433	3.36	2.70	3.07	3.18	2.31	3.09	0.111097054320795	2.04938555437553	0.588800501419612	0.871083043231231	19:57363476-57379565:+	ZNF547	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 547 [Source:HGNC Symbol%3BAcc:HGNC:26432]
ENSG00000173020	24.96	22.32	23.56	23.46	23.04	23.18	0.0391601392877606	5.690793097542	0.588887346662012	0.871083043231231	11:67266409-67286556:+	GRK2	34;GO:0000166,molecular_function nucleotide binding;GO:0002026,biological_process regulation of the force of heart contraction;GO:0002029,biological_process desensitization of G-protein coupled receptor protein signaling pathway;GO:0003108,biological_process negative regulation of the force of heart contraction by chemical signal;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004703,molecular_function G-protein coupled receptor kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007217,biological_process tachykinin receptor signaling pathway;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019079,biological_process viral genome replication;GO:0031623,biological_process receptor internalization;GO:0031694,molecular_function alpha-2A adrenergic receptor binding;GO:0031755,molecular_function Edg-2 lysophosphatidic acid receptor binding;GO:0033605,biological_process positive regulation of catecholamine secretion;GO:0045988,biological_process negative regulation of striated muscle contraction;GO:0046718,biological_process viral entry into host cell;GO:0047696,molecular_function beta-adrenergic receptor kinase activity;GO:0060048,biological_process cardiac muscle contraction	ADRBK, GRK; beta-adrenergic-receptor kinase [EC:2.7.11.15]; K00910	G protein-coupled receptor kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:289]
ENSG00000147403	1286.72	1192.82	1260.85	1265.14	1171.63	1249.09	0.0330341657635586	10.2082426552277	0.588909119374566	0.871083043231231	X:154389954-154409168:+	RPL10	22;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex	RP-L10e, RPL10; large subunit ribosomal protein L10e; K02866	ribosomal protein L10 [Source:HGNC Symbol%3BAcc:HGNC:10298]
ENSG00000093009	9.86	11.14	8.17	9.88	9.17	11.71	-0.0735802896278602	4.19345625541879	0.589081185299075	0.871159295713575	22:19479458-19520612:+	CDC45	24;GO:0000076,biological_process DNA replication checkpoint;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000727,biological_process double-strand break repair via break-induced replication;GO:0003682,molecular_function chromatin binding;GO:0003688,molecular_function DNA replication origin binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005656,cellular_component nuclear pre-replicative complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0006260,biological_process DNA replication;GO:0006267,biological_process pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0007049,biological_process cell cycle;GO:0031261,cellular_component DNA replication preinitiation complex;GO:0031298,cellular_component replication fork protection complex;GO:0031938,biological_process regulation of chromatin silencing at telomere;GO:0032508,biological_process DNA duplex unwinding;GO:0043138,molecular_function 3'-5' DNA helicase activity;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1902977,biological_process mitotic DNA replication preinitiation complex assembly	CDC45; cell division control protein 45; K06628	cell division cycle 45 [Source:HGNC Symbol%3BAcc:HGNC:1739]
ENSG00000004660	15.93	14.02	16.26	16.76	14.14	17.51	-0.0512809145028275	4.76675817901791	0.589101033450395	0.871159295713575	17:3860314-3894891:-	CAMKK1	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0045860,biological_process positive regulation of protein kinase activity	CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]; K07359	calcium/calmodulin dependent protein kinase kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:1469]
ENSG00000114650	23.08	23.31	21.88	21.67	23.41	22.05	0.0354234359909855	6.44357080209826	0.589440509811594	0.871409103273971	3:47413693-47477126:-	SCAP	26;GO:0000139,cellular_component Golgi membrane;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0007568,biological_process aging;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019217,biological_process regulation of fatty acid metabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032403,molecular_function protein complex binding;GO:0032868,biological_process response to insulin;GO:0032933,biological_process SREBP signaling pathway;GO:0042304,biological_process regulation of fatty acid biosynthetic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045541,biological_process negative regulation of cholesterol biosynthetic process;GO:0045716,biological_process positive regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0051082,molecular_function unfolded protein binding	NA	SREBF chaperone [Source:HGNC Symbol%3BAcc:HGNC:30634]
ENSG00000165280	144.70	171.65	136.06	141.45	163.07	136.10	0.0493178224503495	8.49247919040908	0.589575448398196	0.871409103273971	9:35056063-35073249:-	VCP	90;GO:0000166,molecular_function nucleotide binding;GO:0000502,cellular_component proteasome complex;GO:0003723,molecular_function RNA binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006457,biological_process protein folding;GO:0006479,biological_process protein methylation;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006734,biological_process NADH metabolic process;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006914,biological_process autophagy;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008289,molecular_function lipid binding;GO:0010498,biological_process proteasomal protein catabolic process;GO:0010918,biological_process positive regulation of mitochondrial membrane potential;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0019079,biological_process viral genome replication;GO:0019903,molecular_function protein phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0019985,biological_process translesion synthesis;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031593,molecular_function polyubiquitin binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032510,biological_process endosome to lysosome transport via multivesicular body sorting pathway;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0034214,biological_process protein hexamerization;GO:0034774,cellular_component secretory granule lumen;GO:0035578,cellular_component azurophil granule lumen;GO:0035800,molecular_function deubiquitinase activator activity;GO:0035861,cellular_component site of double-strand break;GO:0036435,molecular_function K48-linked polyubiquitin binding;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042288,molecular_function MHC class I protein binding;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043209,cellular_component myelin sheath;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043531,molecular_function ADP binding;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0045184,biological_process establishment of protein localization;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046034,biological_process ATP metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051260,biological_process protein homooligomerization;GO:0055085,biological_process transmembrane transport;GO:0061857,biological_process endoplasmic reticulum stress-induced pre-emptive quality control;GO:0070062,cellular_component extracellular exosome;GO:0070842,biological_process aggresome assembly;GO:0070987,biological_process error-free translesion synthesis;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:0072389,biological_process flavin adenine dinucleotide catabolic process;GO:0097352,biological_process autophagosome maturation;GO:1903006,biological_process positive regulation of protein K63-linked deubiquitination;GO:1903007,biological_process positive regulation of Lys63-specific deubiquitinase activity;GO:1903715,biological_process regulation of aerobic respiration;GO:1903862,biological_process positive regulation of oxidative phosphorylation;GO:1904288,molecular_function BAT3 complex binding;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1904949,cellular_component ATPase complex;GO:1990381,molecular_function ubiquitin-specific protease binding;GO:1990730,cellular_component VCP-NSFL1C complex;GO:2000158,biological_process positive regulation of ubiquitin-specific protease activity;GO:2001171,biological_process positive regulation of ATP biosynthetic process	VCP, CDC48; transitional endoplasmic reticulum ATPase; K13525	valosin containing protein [Source:HGNC Symbol%3BAcc:HGNC:12666]
ENSG00000153086	8.34	8.44	6.94	7.28	8.73	9.21	-0.0832973564806153	3.0657024546116	0.589608762555566	0.871409103273971	2:134838546-134902034:+	ACMSD	16;GO:0001760,molecular_function aminocarboxymuconate-semialdehyde decarboxylase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006569,biological_process tryptophan catabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0046872,molecular_function metal ion binding;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome;GO:1904985,biological_process negative regulation of quinolinate biosynthetic process;GO:1905004,biological_process picolinic acid biosynthetic process;GO:1905012,biological_process regulation of 'de novo' NAD biosynthetic process from tryptophan	ACMSD; aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45]; K03392	aminocarboxymuconate semialdehyde decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:19288]
ENSG00000079739	65.72	69.05	65.34	66.73	62.59	67.56	0.034116856778518	7.04006403475109	0.589652374714736	0.871409103273971	1:63593275-63660245:+	PGM1	22;GO:0000287,molecular_function magnesium ion binding;GO:0004614,molecular_function phosphoglucomutase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0005980,biological_process glycogen catabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0015629,cellular_component actin cytoskeleton;GO:0016853,molecular_function isomerase activity;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0019388,biological_process galactose catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071704,biological_process organic substance metabolic process;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	pgm; phosphoglucomutase [EC:5.4.2.2]; K01835	phosphoglucomutase 1 [Source:HGNC Symbol%3BAcc:HGNC:8905]
ENSG00000133398	156.42	151.25	163.74	159.91	158.61	168.94	-0.0351876010151749	6.02141434311319	0.589681520059183	0.871409103273971	5:6371880-6378594:-	MED10	15;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070847,cellular_component core mediator complex	NA	mediator complex subunit 10 [Source:HGNC Symbol%3BAcc:HGNC:28760]
ENSG00000059804	48.51	44.51	46.29	49.90	39.47	46.82	0.0454585944872653	6.12987309912085	0.589691167928894	0.871409103273971	12:7919229-7936275:-	SLC2A3	25;GO:0005215,molecular_function transporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005536,molecular_function glucose binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0030667,cellular_component secretory granule membrane;GO:0033300,molecular_function dehydroascorbic acid transporter activity;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0055056,molecular_function D-glucose transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0070837,biological_process dehydroascorbic acid transport;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 2 member 3 [Source:HGNC Symbol%3BAcc:HGNC:11007]
ENSG00000013588	16.27	17.27	16.22	15.08	17.33	15.88	0.0515778161499839	4.18774183108816	0.58983976126958	0.87148419176431	12:12890781-12917937:+	GPRC5A	17;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	NA	G protein-coupled receptor class C group 5 member A [Source:HGNC Symbol%3BAcc:HGNC:9836]
ENSG00000162402	11.82	13.31	11.35	11.35	12.30	12.09	0.0388280163399449	6.58537311012593	0.589933209083883	0.87148419176431	1:55066358-55215113:-	USP24	8;GO:0005654,cellular_component nucleoplasm;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 24 [Source:HGNC Symbol%3BAcc:HGNC:12623]
ENSG00000173418	124.08	148.29	132.91	150.97	142.33	127.87	-0.0463405544973262	6.24801038516676	0.590044785901968	0.87148419176431	20:20017115-20033655:+	NAA20	10;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017196,biological_process N-terminal peptidyl-methionine acetylation;GO:0031416,cellular_component NatB complex	NA	N(alpha)-acetyltransferase 20%2C NatB catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:15908]
ENSG00000117543	34.36	30.74	30.99	34.59	31.31	34.21	-0.0445617269118998	4.81596046518007	0.590137684598295	0.87148419176431	1:100989622-101026088:-	DPH5	8;GO:0004164,molecular_function diphthine synthase activity;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0017183,biological_process peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0032259,biological_process methylation	NA	diphthamide biosynthesis 5 [Source:HGNC Symbol%3BAcc:HGNC:24270]
ENSG00000155827	18.64	19.77	18.62	18.30	19.76	17.91	0.0370393766105581	5.7872700015058	0.590143277758857	0.87148419176431	9:101533850-101563344:+	RNF20	29;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0002039,molecular_function p53 binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0003824,molecular_function catalytic activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0010390,biological_process histone monoubiquitination;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016574,biological_process histone ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030336,biological_process negative regulation of cell migration;GO:0031062,biological_process positive regulation of histone methylation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033503,cellular_component HULC complex;GO:0033523,biological_process histone H2B ubiquitination;GO:0042393,molecular_function histone binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:1900364,biological_process negative regulation of mRNA polyadenylation;GO:2001168,biological_process positive regulation of histone H2B ubiquitination	NA	ring finger protein 20 [Source:HGNC Symbol%3BAcc:HGNC:10062]
ENSG00000106404	10.90	8.65	10.59	11.29	10.29	10.52	-0.066520712086824	3.19284944885482	0.59016878558516	0.87148419176431	7:101232091-101238820:-	CLDN15	11;GO:0005198,molecular_function structural molecule activity;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016338,biological_process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030054,cellular_component cell junction;GO:0042802,molecular_function identical protein binding	CLDN; claudin; K06087	claudin 15 [Source:HGNC Symbol%3BAcc:HGNC:2036]
ENSG00000138629	19.21	18.53	16.14	19.77	18.49	18.01	-0.0522647309188159	4.39810361879707	0.590284333009033	0.87148419176431	15:74445976-74461182:-	UBL7	1;GO:0005515,molecular_function protein binding	NA	ubiquitin like 7 [Source:HGNC Symbol%3BAcc:HGNC:28221]
ENSG00000154269	0.52	0.63	0.65	0.50	0.70	0.83	-0.16549086321369	0.916214880285348	0.590341701828136	0.87148419176431	6:131628441-131747418:+	ENPP3	22;GO:0003676,molecular_function nucleic acid binding;GO:0003824,molecular_function catalytic activity;GO:0004528,molecular_function phosphodiesterase I activity;GO:0004551,molecular_function nucleotide diphosphatase activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005576,cellular_component extracellular region;GO:0005887,cellular_component integral component of plasma membrane;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006955,biological_process immune response;GO:0008152,biological_process metabolic process;GO:0009143,biological_process nucleoside triphosphate catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030247,molecular_function polysaccharide binding;GO:0035529,molecular_function NADH pyrophosphatase activity;GO:0046872,molecular_function metal ion binding;GO:0047429,molecular_function nucleoside-triphosphate diphosphatase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]; K01513	ectonucleotide pyrophosphatase/phosphodiesterase 3 [Source:HGNC Symbol%3BAcc:HGNC:3358]
ENSG00000027697	46.77	45.02	45.41	43.68	42.90	48.28	0.0365942731850852	6.11331263137792	0.590440958558299	0.87148419176431	6:137197483-137219449:-	IFNGR1	17;GO:0004906,molecular_function interferon-gamma receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0009615,biological_process response to virus;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019955,molecular_function cytokine binding;GO:0030425,cellular_component dendrite;GO:0031982,cellular_component vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway	IFNGR1, CD119; interferon gamma receptor 1; K05132	interferon gamma receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:5439]
ENSG00000168300	49.08	45.44	53.10	47.95	48.22	48.92	0.0398053898019748	5.97579751055652	0.590501491643629	0.87148419176431	8:51817574-51899186:-	PCMTD1	6;GO:0004719,molecular_function protein-L-isoaspartate (D-aspartate) O-methyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0006479,biological_process protein methylation;GO:0016020,cellular_component membrane;GO:0032259,biological_process methylation	NA	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30483]
ENSG00000148377	1.97	2.39	2.16	1.76	2.00	1.96	0.184750494979765	0.616561756908789	0.590514262219416	0.87148419176431	10:1018906-1025859:-	IDI2	16;GO:0004452,molecular_function isopentenyl-diphosphate delta-isomerase activity;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0009240,biological_process isopentenyl diphosphate biosynthetic process;GO:0016126,biological_process sterol biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0016853,molecular_function isomerase activity;GO:0046490,biological_process isopentenyl diphosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050992,biological_process dimethylallyl diphosphate biosynthetic process	idi, IDI; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]; K01823	isopentenyl-diphosphate delta isomerase 2 [Source:HGNC Symbol%3BAcc:HGNC:23487]
ENSG00000152049	6.07	4.47	5.66	6.10	3.66	5.30	0.129563831253348	1.86091144917898	0.590653099269289	0.871546951041901	2:223051813-223198399:+	KCNE4	13;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005515,molecular_function protein binding;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0044325,molecular_function ion channel binding;GO:0071805,biological_process potassium ion transmembrane transport	NA	potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:6244]
ENSG00000167034	1.81	2.45	3.04	1.81	1.73	2.90	0.177328788423852	0.816150888194611	0.590697212528439	0.871546951041901	8:23678692-23682927:-	NKX3-1	67;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0001047,molecular_function core promoter binding;GO:0001655,biological_process urogenital system development;GO:0001656,biological_process metanephros development;GO:0001756,biological_process somitogenesis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004882,molecular_function androgen receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007431,biological_process salivary gland development;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010942,biological_process positive regulation of cell death;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030284,molecular_function estrogen receptor activity;GO:0030295,molecular_function protein kinase activator activity;GO:0030331,molecular_function estrogen receptor binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030850,biological_process prostate gland development;GO:0032147,biological_process activation of protein kinase activity;GO:0033574,biological_process response to testosterone;GO:0035690,biological_process cellular response to drug;GO:0035907,biological_process dorsal aorta development;GO:0042826,molecular_function histone deacetylase binding;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043491,biological_process protein kinase B signaling;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043569,biological_process negative regulation of insulin-like growth factor receptor signaling pathway;GO:0043621,molecular_function protein self-association;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051781,biological_process positive regulation of cell division;GO:0060037,biological_process pharyngeal system development;GO:0060442,biological_process branching involved in prostate gland morphogenesis;GO:0060664,biological_process epithelial cell proliferation involved in salivary gland morphogenesis;GO:0060770,biological_process negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0071850,biological_process mitotic cell cycle arrest;GO:0071899,biological_process negative regulation of estrogen receptor binding;GO:0097162,molecular_function MADS box domain binding;GO:2000836,biological_process positive regulation of androgen secretion;GO:2001022,biological_process positive regulation of response to DNA damage stimulus;GO:2001235,biological_process positive regulation of apoptotic signaling pathway;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	NKX3-1; homeobox protein Nkx-3.1; K09348	NK3 homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:7838]
ENSG00000104880	0.48	0.43	0.82	0.49	0.63	0.46	0.170423105613537	1.07190157889862	0.590928673220403	0.87178483725753	19:7395112-7472477:+	ARHGEF18	19;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045177,cellular_component apical part of cell;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome	NA	Rho/Rac guanine nucleotide exchange factor 18 [Source:HGNC Symbol%3BAcc:HGNC:17090]
ENSG00000153922	6.49	5.90	6.54	6.27	5.98	6.32	0.0435210894359833	5.08437798390416	0.591059746207587	0.871849980798402	5:98853984-98928957:-	CHD1	18;GO:0000166,molecular_function nucleotide binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0035064,molecular_function methylated histone binding;GO:0043923,biological_process positive regulation by host of viral transcription	NA	chromodomain helicase DNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1915]
ENSG00000175691	3.20	2.81	2.48	3.25	3.20	2.71	-0.0947192254903989	2.31181485713769	0.591113303665459	0.871849980798402	19:2933217-2944971:-	ZNF77	9;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 77 [Source:HGNC Symbol%3BAcc:HGNC:13150]
ENSG00000105127	17.49	16.78	15.77	19.22	14.91	14.36	0.0574774839648475	5.11141697352322	0.591285228612818	0.871999945677903	19:15353384-15379798:-	AKAP8	34;GO:0000278,biological_process mitotic cell cycle;GO:0000793,cellular_component condensed chromosome;GO:0001939,cellular_component female pronucleus;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0007076,biological_process mitotic chromosome condensation;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0033127,biological_process regulation of histone phosphorylation;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0042826,molecular_function histone deacetylase binding;GO:0044839,biological_process cell cycle G2/M phase transition;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051059,molecular_function NF-kappaB binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071380,biological_process cellular response to prostaglandin E stimulus	NA	A-kinase anchoring protein 8 [Source:HGNC Symbol%3BAcc:HGNC:378]
ENSG00000211456	30.16	29.47	31.18	31.16	28.81	29.31	0.0375306998661609	5.72939661159741	0.591456397251211	0.872041693584733	3:45689055-45745424:+	SACM1L	19;GO:0000139,cellular_component Golgi membrane;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0034593,molecular_function phosphatidylinositol bisphosphate phosphatase activity;GO:0034596,molecular_function phosphatidylinositol phosphate 4-phosphatase activity;GO:0042578,molecular_function phosphoric ester hydrolase activity;GO:0043812,molecular_function phosphatidylinositol-4-phosphate phosphatase activity;GO:0046856,biological_process phosphatidylinositol dephosphorylation	NA	SAC1 like phosphatidylinositide phosphatase [Source:HGNC Symbol%3BAcc:HGNC:17059]
ENSG00000138413	173.78	181.13	164.74	163.73	181.36	165.66	0.0361240424737391	7.73832511921035	0.591469850214125	0.872041693584733	2:208236226-208266074:-	IDH1	36;GO:0000287,molecular_function magnesium ion binding;GO:0004448,molecular_function isocitrate dehydrogenase activity;GO:0004450,molecular_function isocitrate dehydrogenase (NADP+) activity;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0005829,cellular_component cytosol;GO:0006097,biological_process glyoxylate cycle;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006102,biological_process isocitrate metabolic process;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006740,biological_process NADPH regeneration;GO:0006749,biological_process glutathione metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0008585,biological_process female gonad development;GO:0014070,biological_process response to organic cyclic compound;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0034774,cellular_component secretory granule lumen;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0048545,biological_process response to steroid hormone;GO:0050661,molecular_function NADP binding;GO:0051287,molecular_function NAD binding;GO:0051990,molecular_function (R)-2-hydroxyglutarate dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060696,biological_process regulation of phospholipid catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0071071,biological_process regulation of phospholipid biosynthetic process;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]; K00031	isocitrate dehydrogenase (NADP(+)) 1%2C cytosolic [Source:HGNC Symbol%3BAcc:HGNC:5382]
ENSG00000168116	7.93	9.23	8.57	9.16	7.93	7.83	0.0517697889595868	4.32514897810862	0.591715976884332	0.872041693584733	6:57046531-57055239:+	KIAA1586	4;GO:0003676,molecular_function nucleic acid binding;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0061665,molecular_function SUMO ligase activity	NA	KIAA1586 [Source:HGNC Symbol%3BAcc:HGNC:21360]
ENSG00000198729	2.00	2.90	3.12	2.72	1.84	4.69	-0.214662237935989	0.662562757440167	0.591718401790689	0.872041693584733	6:150143075-150250357:+	PPP1R14C	6;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0004865,molecular_function protein serine/threonine phosphatase inhibitor activity;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0042325,biological_process regulation of phosphorylation;GO:0043086,biological_process negative regulation of catalytic activity	NA	protein phosphatase 1 regulatory inhibitor subunit 14C [Source:HGNC Symbol%3BAcc:HGNC:14952]
ENSG00000095787	63.60	62.12	63.81	66.86	61.64	67.20	-0.0342178536066054	7.09144832578138	0.5917335517638	0.872041693584733	10:28532492-28623112:+	WAC	18;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010390,biological_process histone monoubiquitination;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0044783,biological_process G1 DNA damage checkpoint;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0071894,biological_process histone H2B conserved C-terminal lysine ubiquitination	NA	WW domain containing adaptor with coiled-coil [Source:HGNC Symbol%3BAcc:HGNC:17327]
ENSG00000117139	16.86	15.57	16.60	15.09	17.20	15.89	0.0388051917922994	6.30189001759932	0.591831016796872	0.872041693584733	1:202724490-202809470:-	KDM5B	39;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007338,biological_process single fertilization;GO:0008270,molecular_function zinc ion binding;GO:0009791,biological_process post-embryonic development;GO:0010628,biological_process positive regulation of gene expression;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0032452,molecular_function histone demethylase activity;GO:0032453,molecular_function histone demethylase activity (H3-K4 specific);GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0034647,molecular_function histone demethylase activity (H3-trimethyl-K4 specific);GO:0034648,molecular_function histone demethylase activity (H3-dimethyl-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0034721,biological_process histone H3-K4 demethylation, trimethyl-H3-K4-specific;GO:0042393,molecular_function histone binding;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0060763,biological_process mammary duct terminal end bud growth;GO:0060992,biological_process response to fungicide;GO:0061038,biological_process uterus morphogenesis;GO:0070306,biological_process lens fiber cell differentiation;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:1990837,molecular_function sequence-specific double-stranded DNA binding;GO:2000864,biological_process regulation of estradiol secretion	NA	lysine demethylase 5B [Source:HGNC Symbol%3BAcc:HGNC:18039]
ENSG00000136261	77.93	79.30	77.82	82.85	77.05	82.79	-0.0351448129028263	6.64819408133391	0.591970088849012	0.872041693584733	7:16646130-16706523:+	BZW2	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0045296,molecular_function cadherin binding	NA	basic leucine zipper and W2 domains 2 [Source:HGNC Symbol%3BAcc:HGNC:18808]
ENSG00000267360	1.14	2.10	1.36	1.56	1.58	0.90	0.171702941083291	0.453631310418675	0.591970664466292	0.872041693584733	19:37093018-37210512:-	AC012309.1	3;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated	KRAB; KRAB domain-containing zinc finger protein; K09228	NA
ENSG00000176915	24.18	23.69	23.92	25.77	22.73	25.78	-0.0374701920624195	6.12410146928478	0.591988677556422	0.872041693584733	12:132725502-132761888:-	ANKLE2	16;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007049,biological_process cell cycle;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0007417,biological_process central nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0042326,biological_process negative regulation of phosphorylation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0050790,biological_process regulation of catalytic activity;GO:0051301,biological_process cell division;GO:0051721,molecular_function protein phosphatase 2A binding	NA	ankyrin repeat and LEM domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29101]
ENSG00000169738	16.85	11.95	13.67	14.00	12.09	14.76	0.07733235358076	3.62441211055716	0.592045210681129	0.872041693584733	17:82035135-82037732:-	DCXR	20;GO:0005634,cellular_component nucleus;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005903,cellular_component brush border;GO:0005975,biological_process carbohydrate metabolic process;GO:0005997,biological_process xylulose metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006739,biological_process NADP metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016614,molecular_function oxidoreductase activity, acting on CH-OH group of donors;GO:0016655,molecular_function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0019640,biological_process glucuronate catabolic process to xylulose 5-phosphate;GO:0042732,biological_process D-xylose metabolic process;GO:0042802,molecular_function identical protein binding;GO:0050038,molecular_function L-xylulose reductase (NADP+) activity;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	DCXR; L-xylulose reductase [EC:1.1.1.10]; K03331	dicarbonyl and L-xylulose reductase [Source:HGNC Symbol%3BAcc:HGNC:18985]
ENSG00000154813	26.41	45.84	34.11	42.31	41.93	30.87	-0.114903546025205	3.19238708689072	0.592086312215591	0.872041693584733	3:16257977-16264972:-	DPH3	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0017183,biological_process peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0046872,molecular_function metal ion binding;GO:0050709,biological_process negative regulation of protein secretion;GO:0051099,biological_process positive regulation of binding	NA	diphthamide biosynthesis 3 [Source:HGNC Symbol%3BAcc:HGNC:27717]
ENSG00000176340	231.33	246.53	212.27	227.51	231.92	216.05	0.0394697845743089	5.56162019168678	0.592323273484945	0.872287198216707	11:63974606-63976543:+	COX8A	10;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	COX8; cytochrome c oxidase subunit 8; K02273	cytochrome c oxidase subunit 8A [Source:HGNC Symbol%3BAcc:HGNC:2294]
ENSG00000138180	45.50	46.61	37.39	43.01	48.65	43.14	-0.0479685603846556	5.98123461864832	0.592473792487171	0.872376353112164	10:93496631-93529092:+	CEP55	17;GO:0000281,biological_process mitotic cytokinesis;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0030496,cellular_component midbody;GO:0032154,cellular_component cleavage furrow;GO:0045171,cellular_component intercellular bridge;GO:0045184,biological_process establishment of protein localization;GO:0051301,biological_process cell division;GO:0090543,cellular_component Flemming body	NA	centrosomal protein 55 [Source:HGNC Symbol%3BAcc:HGNC:1161]
ENSG00000118200	16.55	15.12	16.96	15.22	15.79	16.80	0.03854104256629	6.17575731585119	0.592779401884814	0.872376353112164	1:200739557-200860704:+	CAMSAP2	14;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0030507,molecular_function spectrin binding;GO:0031175,biological_process neuron projection development;GO:0033043,biological_process regulation of organelle organization;GO:0051011,molecular_function microtubule minus-end binding;GO:1990752,cellular_component microtubule end	NA	calmodulin regulated spectrin associated protein family member 2 [Source:HGNC Symbol%3BAcc:HGNC:29188]
ENSG00000123124	36.15	37.77	33.34	35.79	37.08	38.00	-0.0376179389947663	6.70962229006412	0.592943461102931	0.872376353112164	8:86342737-86478420:+	WWP1	21;GO:0000151,cellular_component ubiquitin ligase complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007165,biological_process signal transduction;GO:0007417,biological_process central nervous system development;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0034220,biological_process ion transmembrane transport;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046718,biological_process viral entry into host cell;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome	WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]; K05633	WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:17004]
ENSG00000198917	13.12	9.98	12.60	11.86	12.73	13.18	-0.0575834489030341	3.86194590553968	0.592946609717879	0.872376353112164	9:128819650-128829821:-	SPOUT1	19;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0008150,biological_process biological_process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031616,cellular_component spindle pole centrosome;GO:0032259,biological_process methylation;GO:0051301,biological_process cell division;GO:0051661,biological_process maintenance of centrosome location;GO:0072686,cellular_component mitotic spindle	NA	SPOUT domain containing methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:26933]
ENSG00000230989	344.97	389.54	337.29	362.77	388.97	357.87	-0.0399181104177894	7.11555572660336	0.593049435064232	0.872376353112164	16:83807842-83819737:+	HSBP1	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006936,biological_process muscle contraction;GO:0035987,biological_process endodermal cell differentiation;GO:0042802,molecular_function identical protein binding;GO:1900034,biological_process regulation of cellular response to heat	NA	heat shock factor binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:5203]
ENSG00000049449	411.18	384.65	410.99	416.47	410.00	417.05	-0.0311328456752684	8.94072591504332	0.593051135142721	0.872376353112164	11:31812390-32105755:+	RCN1	9;GO:0001701,biological_process in utero embryonic development;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0043010,biological_process camera-type eye development;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding	NA	reticulocalbin 1 [Source:HGNC Symbol%3BAcc:HGNC:9934]
ENSG00000085872	9.73	10.27	9.69	9.72	9.44	9.86	0.040884471499022	4.77350053264164	0.593096717329397	0.872376353112164	19:16517888-16542530:-	CHERP	17;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0006396,biological_process RNA processing;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0044325,molecular_function ion channel binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0051533,biological_process positive regulation of NFAT protein import into nucleus	CHERP; calcium homeostasis endoplasmic reticulum protein; K12841	calcium homeostasis endoplasmic reticulum protein [Source:HGNC Symbol%3BAcc:HGNC:16930]
ENSG00000158106	11.63	10.94	12.19	11.03	10.90	12.03	0.0480670609787387	4.53722442522134	0.593141133751279	0.872376353112164	8:143368886-143384220:+	RHPN1	3;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction	NA	rhophilin Rho GTPase binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19973]
ENSG00000130304	11.28	11.53	10.97	11.09	10.43	11.43	0.04446653442408	4.53629945359137	0.593180787972161	0.872376353112164	19:17468768-17506168:+	SLC27A1	36;GO:0000166,molecular_function nucleotide binding;GO:0001579,biological_process medium-chain fatty acid transport;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006655,biological_process phosphatidylglycerol biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006659,biological_process phosphatidylserine biosynthetic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008152,biological_process metabolic process;GO:0009409,biological_process response to cold;GO:0012505,cellular_component endomembrane system;GO:0015245,molecular_function fatty acid transporter activity;GO:0015908,biological_process fatty acid transport;GO:0015909,biological_process long-chain fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0031652,biological_process positive regulation of heat generation;GO:0031957,molecular_function very long-chain fatty acid-CoA ligase activity;GO:0032049,biological_process cardiolipin biosynthetic process;GO:0032868,biological_process response to insulin;GO:0033211,biological_process adiponectin-activated signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0071072,biological_process negative regulation of phospholipid biosynthetic process;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity	SLC27A1_4, FATP1, FATP4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]; K08745	solute carrier family 27 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10995]
ENSG00000143321	265.40	293.54	267.71	265.02	286.49	260.96	0.0360278269606942	7.97646333189368	0.593233584080023	0.872376353112164	1:156742106-156766925:-	HDGF	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001222,molecular_function transcription corepressor binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008283,biological_process cell proliferation;GO:0009987,biological_process cellular process;GO:0017053,cellular_component transcriptional repressor complex;GO:0036498,biological_process IRE1-mediated unfolded protein response	NA	heparin binding growth factor [Source:HGNC Symbol%3BAcc:HGNC:4856]
ENSG00000055044	56.77	55.88	51.65	60.09	54.63	55.26	-0.0377980443469586	6.49562240867574	0.593258541246377	0.872376353112164	2:202265715-202303666:+	NOP58	22;GO:0000154,biological_process rRNA modification;GO:0001094,molecular_function TFIID-class transcription factor binding;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031428,cellular_component box C/D snoRNP complex;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis;GO:0048254,biological_process snoRNA localization;GO:0051117,molecular_function ATPase binding;GO:0070761,cellular_component pre-snoRNP complex	NOP58; nucleolar protein 58; K14565	NOP58 ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:29926]
ENSG00000105248	18.95	19.53	19.22	17.69	22.46	20.32	-0.057187667343109	4.26633904670379	0.593430221885971	0.872376353112164	19:4247078-4269090:+	CCDC94	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 94 [Source:HGNC Symbol%3BAcc:HGNC:25518]
ENSG00000144711	5.57	6.12	6.94	6.10	6.36	5.63	0.0555519643687505	4.40942963364142	0.593439163901085	0.872376353112164	3:12897219-13073117:-	IQSEC1	12;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity	IQSEC; IQ motif and SEC7 domain-containing protein; K12495	IQ motif and Sec7 domain 1 [Source:HGNC Symbol%3BAcc:HGNC:29112]
ENSG00000137207	87.74	94.65	88.86	87.84	88.25	90.82	0.0334281666218051	6.82143711431548	0.593441762139787	0.872376353112164	6:43511826-43516990:-	YIPF3	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0030154,biological_process cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	Yip1 domain family member 3 [Source:HGNC Symbol%3BAcc:HGNC:21023]
ENSG00000070759	3.05	3.18	3.22	3.45	3.32	3.33	-0.0848281463904286	2.52058990072581	0.593532222027893	0.872376353112164	1:45343882-45491166:-	TESK2	22;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007283,biological_process spermatogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030036,biological_process actin cytoskeleton organization;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding;GO:0048041,biological_process focal adhesion assembly	NA	testis-specific kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:11732]
ENSG00000170260	8.05	9.01	6.47	7.71	8.64	8.42	-0.0718466180103293	3.81053792705222	0.593708687714179	0.872376353112164	7:149239650-149255609:+	ZNF212	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 212 [Source:HGNC Symbol%3BAcc:HGNC:13004]
ENSG00000124787	9.41	10.27	9.94	11.37	9.83	9.99	-0.0671380460642176	3.53087018357776	0.593838424616302	0.872376353112164	6:4994731-5004063:-	RPP40	11;GO:0001682,biological_process tRNA 5'-leader removal;GO:0004526,molecular_function ribonuclease P activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005655,cellular_component nucleolar ribonuclease P complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	RPP40; ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]; K14530	ribonuclease P/MRP subunit p40 [Source:HGNC Symbol%3BAcc:HGNC:20992]
ENSG00000104218	12.98	13.24	13.24	12.56	14.39	13.91	-0.0388482336970149	5.69961633102533	0.593838882995731	0.872376353112164	8:67062425-67196263:+	CSPP1	9;GO:0000922,cellular_component spindle pole;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0032467,biological_process positive regulation of cytokinesis;GO:0051781,biological_process positive regulation of cell division	NA	centrosome and spindle pole associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:26193]
ENSG00000136280	34.15	39.50	35.45	35.09	36.77	35.00	0.0373550145658469	5.8055574052205	0.593887157431208	0.872376353112164	7:44999474-45076469:+	CCM2	20;GO:0001568,biological_process blood vessel development;GO:0001570,biological_process vasculogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001885,biological_process endothelial cell development;GO:0001944,biological_process vasculature development;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0035264,biological_process multicellular organism growth;GO:0043234,cellular_component protein complex;GO:0045216,biological_process cell-cell junction organization;GO:0048839,biological_process inner ear development;GO:0048845,biological_process venous blood vessel morphogenesis;GO:0051403,biological_process stress-activated MAPK cascade;GO:0060039,biological_process pericardium development;GO:0060837,biological_process blood vessel endothelial cell differentiation;GO:0061154,biological_process endothelial tube morphogenesis	NA	CCM2 scaffolding protein [Source:HGNC Symbol%3BAcc:HGNC:21708]
ENSG00000100387	199.45	205.58	194.23	201.97	204.82	211.61	-0.0354459488017579	6.04291400740578	0.5939812646367	0.872376353112164	22:40951346-40973309:+	RBX1	55;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0010265,biological_process SCF complex assembly;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019788,molecular_function NEDD8 transferase activity;GO:0030163,biological_process protein catabolic process;GO:0030891,cellular_component VCB complex;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0031465,cellular_component Cul4B-RING E3 ubiquitin ligase complex;GO:0031466,cellular_component Cul5-RING ubiquitin ligase complex;GO:0031467,cellular_component Cul7-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043224,cellular_component nuclear SCF ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0046872,molecular_function metal ion binding;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097602,molecular_function cullin family protein binding	RBX1, ROC1; RING-box protein 1 [EC:2.3.2.32]; K03868	ring-box 1 [Source:HGNC Symbol%3BAcc:HGNC:9928]
ENSG00000154803	23.33	22.63	26.22	24.22	23.65	22.93	0.0426438474563723	5.50126265970772	0.594006343085361	0.872376353112164	17:17212211-17237188:-	FLCN	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001701,biological_process in utero embryonic development;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007043,biological_process cell-cell junction assembly;GO:0010508,biological_process positive regulation of autophagy;GO:0010629,biological_process negative regulation of gene expression;GO:0010823,biological_process negative regulation of mitochondrion organization;GO:0030097,biological_process hemopoiesis;GO:0030308,biological_process negative regulation of cell growth;GO:0030336,biological_process negative regulation of cell migration;GO:0030496,cellular_component midbody;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0031929,biological_process TOR signaling;GO:0032006,biological_process regulation of TOR signaling;GO:0032007,biological_process negative regulation of TOR signaling;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032403,molecular_function protein complex binding;GO:0032465,biological_process regulation of cytokinesis;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0035065,biological_process regulation of histone acetylation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044291,cellular_component cell-cell contact zone;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:1900181,biological_process negative regulation of protein localization to nucleus;GO:1901723,biological_process negative regulation of cell proliferation involved in kidney development;GO:2000506,biological_process negative regulation of energy homeostasis;GO:2000973,biological_process regulation of pro-B cell differentiation;GO:2001170,biological_process negative regulation of ATP biosynthetic process	FLCN, BHD; folliculin; K09594	folliculin [Source:HGNC Symbol%3BAcc:HGNC:27310]
ENSG00000141564	7.12	6.53	6.34	6.35	7.05	7.42	-0.0461356688441711	4.92044285269825	0.594040965151116	0.872376353112164	17:80544818-80966371:+	RPTOR	43;GO:0001030,molecular_function RNA polymerase III type 1 promoter DNA binding;GO:0001031,molecular_function RNA polymerase III type 2 promoter DNA binding;GO:0001032,molecular_function RNA polymerase III type 3 promoter DNA binding;GO:0001156,molecular_function TFIIIC-class transcription factor binding;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0007050,biological_process cell cycle arrest;GO:0008361,biological_process regulation of cell size;GO:0009267,biological_process cellular response to starvation;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010506,biological_process regulation of autophagy;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0016049,biological_process cell growth;GO:0016241,biological_process regulation of macroautophagy;GO:0019901,molecular_function protein kinase binding;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0030295,molecular_function protein kinase activator activity;GO:0030307,biological_process positive regulation of cell growth;GO:0030425,cellular_component dendrite;GO:0030674,molecular_function protein binding, bridging;GO:0031669,biological_process cellular response to nutrient levels;GO:0031929,biological_process TOR signaling;GO:0031931,cellular_component TORC1 complex;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032147,biological_process activation of protein kinase activity;GO:0032403,molecular_function protein complex binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0038202,biological_process TORC1 signaling;GO:0042325,biological_process regulation of phosphorylation;GO:0043025,cellular_component neuronal cell body;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071233,biological_process cellular response to leucine;GO:0071889,molecular_function 14-3-3 protein binding;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:1900034,biological_process regulation of cellular response to heat;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle	RAPTOR; regulatory associated protein of mTOR; K07204	regulatory associated protein of MTOR complex 1 [Source:HGNC Symbol%3BAcc:HGNC:30287]
ENSG00000117419	44.08	48.90	45.17	49.13	48.61	45.13	-0.0396537355238397	5.86903358590753	0.594094866363459	0.872376353112164	1:44221069-44355260:-	ERI3	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0006259,biological_process DNA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	ERI1 exoribonuclease family member 3 [Source:HGNC Symbol%3BAcc:HGNC:17276]
ENSG00000066044	49.53	59.75	53.12	56.49	61.01	51.33	-0.0470911301218707	6.07805266893984	0.594109286844253	0.872376353112164	19:7958578-8005659:-	ELAVL1	24;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0017091,molecular_function AU-rich element binding;GO:0019901,molecular_function protein kinase binding;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043488,biological_process regulation of mRNA stability;GO:0045727,biological_process positive regulation of translation;GO:0048255,biological_process mRNA stabilization;GO:0060965,biological_process negative regulation of gene silencing by miRNA;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:1990904,cellular_component ribonucleoprotein complex;GO:2000036,biological_process regulation of stem cell population maintenance	ELAVL1, HUR; ELAV-like protein 1; K13088	ELAV like RNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3312]
ENSG00000165995	0.72	0.72	0.45	0.66	0.47	0.53	0.187837619525471	0.568039584011638	0.594201046951549	0.872376353112164	10:18140676-18541869:+	CACNB2	32;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007528,biological_process neuromuscular junction development;GO:0007601,biological_process visual perception;GO:0008331,molecular_function high voltage-gated calcium channel activity;GO:0016020,cellular_component membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042383,cellular_component sarcolemma;GO:0051015,molecular_function actin filament binding;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0061337,biological_process cardiac conduction;GO:0070509,biological_process calcium ion import;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086007,molecular_function voltage-gated calcium channel activity involved in cardiac muscle cell action potential;GO:0086045,biological_process membrane depolarization during AV node cell action potential;GO:0086056,molecular_function voltage-gated calcium channel activity involved in AV node cell action potential;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0098912,biological_process membrane depolarization during atrial cardiac muscle cell action potential;GO:1901385,biological_process regulation of voltage-gated calcium channel activity;GO:1901843,biological_process positive regulation of high voltage-gated calcium channel activity;GO:1904879,biological_process positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:1990454,cellular_component L-type voltage-gated calcium channel complex	CACNB2; voltage-dependent calcium channel beta-2; K04863	calcium voltage-gated channel auxiliary subunit beta 2 [Source:HGNC Symbol%3BAcc:HGNC:1402]
ENSG00000116151	4.54	6.32	5.57	5.48	4.56	5.53	0.074651919786035	3.17967048140919	0.594256596794643	0.872376353112164	1:2321252-2391707:-	MORN1	NA	NA	MORN repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25852]
ENSG00000117411	50.14	55.85	49.31	51.28	52.14	48.87	0.0365853818828105	5.94913031935964	0.594281353574193	0.872376353112164	1:43978942-43991170:+	B4GALT2	22;GO:0000139,cellular_component Golgi membrane;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945,molecular_function N-acetyllactosamine synthase activity;GO:0004461,molecular_function lactose synthase activity;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0007420,biological_process brain development;GO:0007613,biological_process memory;GO:0007626,biological_process locomotory behavior;GO:0008378,molecular_function galactosyltransferase activity;GO:0008542,biological_process visual learning;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0021680,biological_process cerebellar Purkinje cell layer development;GO:0032580,cellular_component Golgi cisterna membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	B4GALT2; beta-1,4-galactosyltransferase 2 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]; K07967	beta-1%2C4-galactosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:925]
ENSG00000145414	5.38	5.34	6.10	5.15	5.45	5.57	0.0715835183580779	3.18876536480272	0.594371330162991	0.872405264433393	4:163110072-163166921:-	NAF1	19;GO:0000454,biological_process snoRNA guided rRNA pseudouridine synthesis;GO:0000493,biological_process box H/ACA snoRNP assembly;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0042254,biological_process ribosome biogenesis;GO:0043489,biological_process RNA stabilization;GO:0051973,biological_process positive regulation of telomerase activity;GO:0070034,molecular_function telomerase RNA binding;GO:0090669,biological_process telomerase RNA stabilization;GO:1904358,biological_process positive regulation of telomere maintenance via telomere lengthening;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body;GO:1905323,biological_process telomerase holoenzyme complex assembly	NA	nuclear assembly factor 1 ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:25126]
ENSG00000113460	63.62	54.33	56.02	64.97	55.36	60.49	-0.0416555056819534	5.9745446021228	0.594482637987926	0.872465474739196	5:34915375-34925996:+	BRIX1	5;GO:0000027,biological_process ribosomal large subunit assembly;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0042254,biological_process ribosome biogenesis	NA	BRX1%2C biogenesis of ribosomes [Source:HGNC Symbol%3BAcc:HGNC:24170]
ENSG00000175283	7.96	8.05	7.07	7.00	8.88	8.45	-0.0679122133331238	3.69035769278221	0.594576264236101	0.872499724312888	9:128945529-128947619:-	DOLK	13;GO:0004168,molecular_function dolichol kinase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006489,biological_process dolichyl diphosphate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0043048,biological_process dolichyl monophosphate biosynthetic process	DOLK; dolichol kinase [EC:2.7.1.108]; K00902	dolichol kinase [Source:HGNC Symbol%3BAcc:HGNC:23406]
ENSG00000128266	2.19	1.44	1.80	1.55	1.78	1.58	0.178130439433442	1.00033853770862	0.594686250728375	0.872557970483608	22:23070360-23125037:+	GNAZ	24;GO:0000166,molecular_function nucleotide binding;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005525,molecular_function GTP binding;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0030425,cellular_component dendrite;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031821,molecular_function G-protein coupled serotonin receptor binding;GO:0044297,cellular_component cell body;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	GNAZ; guanine nucleotide-binding protein G(z) subunit alpha; K04535	G protein subunit alpha z [Source:HGNC Symbol%3BAcc:HGNC:4395]
ENSG00000134531	4.11	4.14	5.49	4.69	1.81	5.77	0.172144631449197	1.62101404255287	0.594926713694785	0.872807622868853	12:13196715-13219939:+	EMP1	10;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008219,biological_process cell death;GO:0008283,biological_process cell proliferation;GO:0008544,biological_process epidermis development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0032060,biological_process bleb assembly	NA	epithelial membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3333]
ENSG00000065268	27.12	25.57	25.82	27.36	25.61	28.46	-0.0401812141469776	5.12011834376419	0.595047460430529	0.872881603205408	19:984270-998438:+	WDR18	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0007275,biological_process multicellular organism development	NA	WD repeat domain 18 [Source:HGNC Symbol%3BAcc:HGNC:17956]
ENSG00000112599	4.12	3.34	5.64	3.49	3.54	4.92	0.157328921672862	1.42392448445622	0.595254951355015	0.873082797018765	6:42184400-42194916:-	GUCA1B	18;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0007168,biological_process receptor guanylyl cyclase signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007589,biological_process body fluid secretion;GO:0007601,biological_process visual perception;GO:0007602,biological_process phototransduction;GO:0008048,molecular_function calcium sensitive guanylate cyclase activator activity;GO:0016020,cellular_component membrane;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0030249,molecular_function guanylate cyclase regulator activity;GO:0031282,biological_process regulation of guanylate cyclase activity;GO:0031284,biological_process positive regulation of guanylate cyclase activity;GO:0046872,molecular_function metal ion binding;GO:0050896,biological_process response to stimulus;GO:0097381,cellular_component photoreceptor disc membrane	GUCA1; guanylate cyclase activator 1; K08328	guanylate cyclase activator 1B [Source:HGNC Symbol%3BAcc:HGNC:4679]
ENSG00000160710	76.73	73.74	78.86	82.59	74.96	79.15	-0.0334447020164423	8.16014133687814	0.595395104908064	0.873185188707916	1:154582061-154627999:-	ADAR	41;GO:0001649,biological_process osteoblast differentiation;GO:0001701,biological_process in utero embryonic development;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002376,biological_process immune system process;GO:0002566,biological_process somatic diversification of immune receptors via somatic mutation;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003726,molecular_function double-stranded RNA adenosine deaminase activity;GO:0004000,molecular_function adenosine deaminase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006382,biological_process adenosine to inosine editing;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016553,biological_process base conversion or substitution editing;GO:0016787,molecular_function hydrolase activity;GO:0030218,biological_process erythrocyte differentiation;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0035280,biological_process miRNA loading onto RISC involved in gene silencing by miRNA;GO:0035455,biological_process response to interferon-alpha;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044387,biological_process negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0044530,cellular_component supraspliceosomal complex;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0060216,biological_process definitive hemopoiesis;GO:0060337,biological_process type I interferon signaling pathway;GO:0060339,biological_process negative regulation of type I interferon-mediated signaling pathway;GO:0061484,biological_process hematopoietic stem cell homeostasis;GO:0098586,biological_process cellular response to virus;GO:1900369,biological_process negative regulation of RNA interference	ADAR, ADAR1; double-stranded RNA-specific adenosine deaminase [EC:3.5.4.37]; K12968	adenosine deaminase%2C RNA specific [Source:HGNC Symbol%3BAcc:HGNC:225]
ENSG00000197971	20.06	14.93	20.38	19.13	16.13	18.43	0.0631558929693696	4.94866071322607	0.595660053702215	0.873470554826414	18:76978826-77133683:-	MBP	30;GO:0000165,biological_process MAPK cascade;GO:0002020,molecular_function protease binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0007268,biological_process chemical synaptic transmission;GO:0007417,biological_process central nervous system development;GO:0007605,biological_process sensory perception of sound;GO:0008366,biological_process axon ensheathment;GO:0009636,biological_process response to toxic substance;GO:0016020,cellular_component membrane;GO:0019911,molecular_function structural constituent of myelin sheath;GO:0021762,biological_process substantia nigra development;GO:0033269,cellular_component internode region of axon;GO:0034115,biological_process negative regulation of heterotypic cell-cell adhesion;GO:0035633,biological_process maintenance of blood-brain barrier;GO:0042552,biological_process myelination;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043209,cellular_component myelin sheath;GO:0043218,cellular_component compact myelin;GO:0043234,cellular_component protein complex;GO:0061024,biological_process membrane organization;GO:0071944,cellular_component cell periphery;GO:1904209,biological_process positive regulation of chemokine (C-C motif) ligand 2 secretion;GO:1904685,biological_process positive regulation of metalloendopeptidase activity;GO:2000778,biological_process positive regulation of interleukin-6 secretion	NA	myelin basic protein [Source:HGNC Symbol%3BAcc:HGNC:6925]
ENSG00000090975	4.81	4.93	5.80	5.48	5.15	5.62	-0.0507622962097967	4.55603483843626	0.595790153957182	0.873558136200154	12:122983479-123150015:-	PITPNM2	13;GO:0005509,molecular_function calcium ion binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0008152,biological_process metabolic process;GO:0008289,molecular_function lipid binding;GO:0008526,molecular_function phosphatidylinositol transporter activity;GO:0012505,cellular_component endomembrane system;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	phosphatidylinositol transfer protein membrane associated 2 [Source:HGNC Symbol%3BAcc:HGNC:21044]
ENSG00000112759	36.96	29.48	38.63	40.17	30.49	39.89	-0.058294366552894	5.62904986046125	0.595939742629365	0.873656117413676	6:44219504-44234151:+	SLC29A1	18;GO:0005337,molecular_function nucleoside transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006810,biological_process transport;GO:0007595,biological_process lactation;GO:0015858,biological_process nucleoside transport;GO:0015862,biological_process uridine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030431,biological_process sleep;GO:0060079,biological_process excitatory postsynaptic potential;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0098794,cellular_component postsynapse;GO:1901642,biological_process nucleoside transmembrane transport	SLC29A1_2_3, ENT1_2_3; solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3; K15014	solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol%3BAcc:HGNC:11003]
ENSG00000147687	50.95	48.35	54.60	52.09	47.71	60.40	-0.0450538702003214	5.94280245925849	0.595997744482318	0.873656117413676	8:124488484-124539458:-	TATDN1	12;GO:0004518,molecular_function nuclease activity;GO:0004536,molecular_function deoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006259,biological_process DNA metabolic process;GO:0006308,biological_process DNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0016888,molecular_function endodeoxyribonuclease activity, producing 5'-phosphomonoesters;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	TatD DNase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24220]
ENSG00000196591	121.82	125.36	117.68	121.56	127.48	127.14	-0.0329475422995274	7.5362933877583	0.596159354239498	0.873789829280304	6:113933027-114011308:-	HDAC2	84;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001975,biological_process response to amphetamine;GO:0003300,biological_process cardiac muscle hypertrophy;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006344,biological_process maintenance of chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009913,biological_process epidermal cell differentiation;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010870,biological_process positive regulation of receptor biosynthetic process;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016358,biological_process dendrite development;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016580,cellular_component Sin3 complex;GO:0016581,cellular_component NuRD complex;GO:0016787,molecular_function hydrolase activity;GO:0019213,molecular_function deacetylase activity;GO:0019899,molecular_function enzyme binding;GO:0031000,biological_process response to caffeine;GO:0031072,molecular_function heat shock protein binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0032496,biological_process response to lipopolysaccharide;GO:0032732,biological_process positive regulation of interleukin-1 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032922,biological_process circadian regulation of gene expression;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0033558,molecular_function protein deacetylase activity;GO:0034605,biological_process cellular response to heat;GO:0035094,biological_process response to nicotine;GO:0035098,cellular_component ESC/E(Z) complex;GO:0042220,biological_process response to cocaine;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042493,biological_process response to drug;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042826,molecular_function histone deacetylase binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043392,biological_process negative regulation of DNA binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045347,biological_process negative regulation of MHC class II biosynthetic process;GO:0045862,biological_process positive regulation of proteolysis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048149,biological_process behavioral response to ethanol;GO:0048511,biological_process rhythmic process;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0051059,molecular_function NF-kappaB binding;GO:0055093,biological_process response to hyperoxia;GO:0060789,biological_process hair follicle placode formation;GO:0061000,biological_process negative regulation of dendritic spine development;GO:0061029,biological_process eyelid development in camera-type eye;GO:0061198,biological_process fungiform papilla formation;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070932,biological_process histone H3 deacetylation;GO:0070933,biological_process histone H4 deacetylation;GO:0071300,biological_process cellular response to retinoic acid;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1903351,biological_process cellular response to dopamine;GO:2000757,biological_process negative regulation of peptidyl-lysine acetylation	HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]; K06067	histone deacetylase 2 [Source:HGNC Symbol%3BAcc:HGNC:4853]
ENSG00000254901	3.74	2.72	1.65	1.22	4.02	1.72	0.24217007604236	0.465669430039915	0.596383178293599	0.874014686205248	19:19176902-19192591:-	BORCS8	6;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0099078,cellular_component BORC complex	NA	BLOC-1 related complex subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:37247]
ENSG00000126804	32.66	31.36	34.75	34.63	33.92	33.56	-0.0341070129630998	6.18967339958522	0.596707460617885	0.874281740443939	14:64503711-64533690:+	ZBTB1	31;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002376,biological_process immune system process;GO:0002711,biological_process positive regulation of T cell mediated immunity;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016604,cellular_component nuclear body;GO:0019985,biological_process translesion synthesis;GO:0030154,biological_process cell differentiation;GO:0030183,biological_process B cell differentiation;GO:0031965,cellular_component nuclear membrane;GO:0032825,biological_process positive regulation of natural killer cell differentiation;GO:0033077,biological_process T cell differentiation in thymus;GO:0034644,biological_process cellular response to UV;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0045087,biological_process innate immune response;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048538,biological_process thymus development;GO:0051260,biological_process protein homooligomerization;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:2000176,biological_process positive regulation of pro-T cell differentiation	NA	zinc finger and BTB domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20259]
ENSG00000167323	38.18	36.86	38.59	39.40	34.87	37.46	0.0367212586316256	6.56238737024746	0.596753943145685	0.874281740443939	11:3854526-4093210:+	STIM1	37;GO:0002020,molecular_function protease binding;GO:0002115,biological_process store-operated calcium entry;GO:0005246,molecular_function calcium channel regulator activity;GO:0005509,molecular_function calcium ion binding;GO:0005513,biological_process detection of calcium ion;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0014902,biological_process myotube differentiation;GO:0015279,molecular_function store-operated calcium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030426,cellular_component growth cone;GO:0032237,biological_process activation of store-operated calcium channel activity;GO:0032541,cellular_component cortical endoplasmic reticulum;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0051010,molecular_function microtubule plus-end binding;GO:0051924,biological_process regulation of calcium ion transport;GO:0070166,biological_process enamel mineralization;GO:0070588,biological_process calcium ion transmembrane transport;GO:1903779,biological_process regulation of cardiac conduction;GO:2001256,biological_process regulation of store-operated calcium entry	STIM1; stromal interaction molecule 1; K16059	stromal interaction molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:11386]
ENSG00000116604	12.73	9.46	13.57	14.60	10.27	13.17	-0.0709474840880354	4.40367192170354	0.596776700779948	0.874281740443939	1:156463726-156500828:-	MEF2D	32;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001649,biological_process osteoblast differentiation;GO:0001958,biological_process endochondral ossification;GO:0002062,biological_process chondrocyte differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007512,biological_process adult heart development;GO:0007517,biological_process muscle organ development;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0033613,molecular_function activating transcription factor binding;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity	MEF2D; MADS-box transcription enhancer factor 2D; K09262	myocyte enhancer factor 2D [Source:HGNC Symbol%3BAcc:HGNC:6997]
ENSG00000172346	10.32	8.06	6.98	9.36	8.91	9.11	-0.0919247131181055	2.58785830616802	0.59696442651497	0.874453555148728	22:41560762-41577741:+	CSDC2	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008134,molecular_function transcription factor binding;GO:0043488,biological_process regulation of mRNA stability	NA	cold shock domain containing C2 [Source:HGNC Symbol%3BAcc:HGNC:30359]
ENSG00000143799	47.16	54.37	46.50	47.10	50.78	47.27	0.0384920909434056	7.31640170130672	0.597170718642399	0.874635027234887	1:226360690-226408079:-	PARP1	87;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003910,molecular_function DNA ligase (ATP) activity;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006273,biological_process lagging strand elongation;GO:0006281,biological_process DNA repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006302,biological_process double-strand break repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006471,biological_process protein ADP-ribosylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007005,biological_process mitochondrion organization;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0010332,biological_process response to gamma radiation;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0010990,biological_process regulation of SMAD protein complex assembly;GO:0016020,cellular_component membrane;GO:0016540,biological_process protein autoprocessing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018312,biological_process peptidyl-serine ADP-ribosylation;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0023019,biological_process signal transduction involved in regulation of gene expression;GO:0030225,biological_process macrophage differentiation;GO:0030331,molecular_function estrogen receptor binding;GO:0032042,biological_process mitochondrial DNA metabolic process;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032993,cellular_component protein-DNA complex;GO:0033148,biological_process positive regulation of intracellular estrogen receptor signaling pathway;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034599,biological_process cellular response to oxidative stress;GO:0036211,biological_process protein modification process;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042802,molecular_function identical protein binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043234,cellular_component protein complex;GO:0043504,biological_process mitochondrial DNA repair;GO:0044030,biological_process regulation of DNA methylation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0050790,biological_process regulation of catalytic activity;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0051287,molecular_function NAD binding;GO:0051901,biological_process positive regulation of mitochondrial depolarization;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0070212,biological_process protein poly-ADP-ribosylation;GO:0070412,molecular_function R-SMAD binding;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0071294,biological_process cellular response to zinc ion;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901216,biological_process positive regulation of neuron death;GO:1903376,biological_process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903827,biological_process regulation of cellular protein localization;GO:1904044,biological_process response to aldosterone;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1904646,biological_process cellular response to beta-amyloid;GO:1904762,biological_process positive regulation of myofibroblast differentiation;GO:1990404,molecular_function protein ADP-ribosylase activity;GO:1990966,biological_process ATP generation from poly-ADP-D-ribose;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding;GO:2001170,biological_process negative regulation of ATP biosynthetic process	PARP; poly [ADP-ribose] polymerase [EC:2.4.2.30]; K10798	poly(ADP-ribose) polymerase 1 [Source:HGNC Symbol%3BAcc:HGNC:270]
ENSG00000099984	1.54	1.04	1.31	1.02	0.62	3.17	-0.290030791175872	0.310393747421594	0.597229234741231	0.874635027234887	22:23980057-23983915:+	GSTT2	NA	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase theta 2 (gene/pseudogene) [Source:HGNC Symbol%3BAcc:HGNC:4642]
ENSG00000131778	16.88	19.03	17.53	18.78	17.14	16.36	0.0404809178952552	5.57065241990249	0.597379610819304	0.874672423411686	1:147242640-147295766:+	CHD1L	22;GO:0000166,molecular_function nucleotide binding;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006338,biological_process chromatin remodeling;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0070911,biological_process global genome nucleotide-excision repair	NA	chromodomain helicase DNA binding protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:1916]
ENSG00000214776	0.45	0.50	0.23	0.51	0.29	0.53	-0.1815560384633	0.992074959585635	0.597395698516416	0.874672423411686	12:9467551-9576275:+	AC092821.1	4;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0010951,biological_process negative regulation of endopeptidase activity	NA	NA
ENSG00000078142	12.86	14.29	13.56	12.80	13.40	13.66	0.0375631527959297	5.2353650843619	0.597490709977269	0.874708359824018	18:41955205-42087830:+	PIK3C3	50;GO:0000045,biological_process autophagosome assembly;GO:0000166,molecular_function nucleotide binding;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000910,biological_process cytokinesis;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006468,biological_process protein phosphorylation;GO:0006497,biological_process protein lipidation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0007032,biological_process endosome organization;GO:0007049,biological_process cell cycle;GO:0009267,biological_process cellular response to starvation;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016485,biological_process protein processing;GO:0016740,molecular_function transferase activity;GO:0030242,biological_process pexophagy;GO:0030496,cellular_component midbody;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032465,biological_process regulation of cytokinesis;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0034271,cellular_component phosphatidylinositol 3-kinase complex, class III, type I;GO:0034272,cellular_component phosphatidylinositol 3-kinase complex, class III, type II;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0035004,molecular_function phosphatidylinositol 3-kinase activity;GO:0035032,cellular_component phosphatidylinositol 3-kinase complex, class III;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0042149,biological_process cellular response to glucose starvation;GO:0043201,biological_process response to leucine;GO:0044754,cellular_component autolysosome;GO:0045022,biological_process early endosome to late endosome transport;GO:0045335,cellular_component phagocytic vesicle;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050708,biological_process regulation of protein secretion;GO:0051301,biological_process cell division	PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]; K00914	phosphatidylinositol 3-kinase catalytic subunit type 3 [Source:HGNC Symbol%3BAcc:HGNC:8974]
ENSG00000131725	9.05	9.71	9.38	9.65	9.88	9.66	-0.044403777239026	4.74674873101161	0.59756832568952	0.874718823913209	X:118346072-118449961:+	WDR44	7;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	WD repeat domain 44 [Source:HGNC Symbol%3BAcc:HGNC:30512]
ENSG00000148400	5.22	5.01	5.27	5.61	5.02	5.44	-0.0383933344699335	5.34086276042524	0.597658216280676	0.874747251349136	9:136494443-136545862:-	NOTCH1	191;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000139,cellular_component Golgi membrane;GO:0001047,molecular_function core promoter binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001525,biological_process angiogenesis;GO:0001669,cellular_component acrosomal vesicle;GO:0001701,biological_process in utero embryonic development;GO:0001708,biological_process cell fate specification;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001889,biological_process liver development;GO:0001947,biological_process heart looping;GO:0002040,biological_process sprouting angiogenesis;GO:0002052,biological_process positive regulation of neuroblast proliferation;GO:0002193,cellular_component MAML1-RBP-Jkappa- ICN1 complex;GO:0002437,biological_process inflammatory response to antigenic stimulus;GO:0003157,biological_process endocardium development;GO:0003160,biological_process endocardium morphogenesis;GO:0003162,biological_process atrioventricular node development;GO:0003169,biological_process coronary vein morphogenesis;GO:0003180,biological_process aortic valve morphogenesis;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003184,biological_process pulmonary valve morphogenesis;GO:0003192,biological_process mitral valve formation;GO:0003197,biological_process endocardial cushion development;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003207,biological_process cardiac chamber formation;GO:0003208,biological_process cardiac ventricle morphogenesis;GO:0003209,biological_process cardiac atrium morphogenesis;GO:0003213,biological_process cardiac right atrium morphogenesis;GO:0003214,biological_process cardiac left ventricle morphogenesis;GO:0003219,biological_process cardiac right ventricle formation;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003241,biological_process growth involved in heart morphogenesis;GO:0003256,biological_process regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003264,biological_process regulation of cardioblast proliferation;GO:0003270,biological_process Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation;GO:0003273,biological_process cell migration involved in endocardial cushion formation;GO:0003344,biological_process pericardium morphogenesis;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004857,molecular_function enzyme inhibitor activity;GO:0004872,molecular_function receptor activity;GO:0005112,molecular_function Notch binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0006959,biological_process humoral immune response;GO:0007219,biological_process Notch signaling pathway;GO:0007221,biological_process positive regulation of transcription of Notch receptor target;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007368,biological_process determination of left/right symmetry;GO:0007386,biological_process compartment pattern specification;GO:0007409,biological_process axonogenesis;GO:0007420,biological_process brain development;GO:0007440,biological_process foregut morphogenesis;GO:0007492,biological_process endoderm development;GO:0007507,biological_process heart development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008544,biological_process epidermis development;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0009912,biological_process auditory receptor cell fate commitment;GO:0009986,cellular_component cell surface;GO:0010001,biological_process glial cell differentiation;GO:0010468,biological_process regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0014031,biological_process mesenchymal cell development;GO:0014807,biological_process regulation of somitogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019899,molecular_function enzyme binding;GO:0021515,biological_process cell differentiation in spinal cord;GO:0021915,biological_process neural tube development;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030279,biological_process negative regulation of ossification;GO:0030324,biological_process lung development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030334,biological_process regulation of cell migration;GO:0030335,biological_process positive regulation of cell migration;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030900,biological_process forebrain development;GO:0031069,biological_process hair follicle morphogenesis;GO:0031100,biological_process organ regeneration;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031490,molecular_function chromatin DNA binding;GO:0031960,biological_process response to corticosteroid;GO:0032495,biological_process response to muramyl dipeptide;GO:0032496,biological_process response to lipopolysaccharide;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035148,biological_process tube formation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0042127,biological_process regulation of cell proliferation;GO:0042246,biological_process tissue regeneration;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043235,cellular_component receptor complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045165,biological_process cell fate commitment;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045603,biological_process positive regulation of endothelial cell differentiation;GO:0045607,biological_process regulation of auditory receptor cell differentiation;GO:0045608,biological_process negative regulation of auditory receptor cell differentiation;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045687,biological_process positive regulation of glial cell differentiation;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045955,biological_process negative regulation of calcium ion-dependent exocytosis;GO:0046427,biological_process positive regulation of JAK-STAT cascade;GO:0046533,biological_process negative regulation of photoreceptor cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048103,biological_process somatic stem cell division;GO:0048663,biological_process neuron fate commitment;GO:0048708,biological_process astrocyte differentiation;GO:0048709,biological_process oligodendrocyte differentiation;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0048715,biological_process negative regulation of oligodendrocyte differentiation;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048845,biological_process venous blood vessel morphogenesis;GO:0050678,biological_process regulation of epithelial cell proliferation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050767,biological_process regulation of neurogenesis;GO:0050768,biological_process negative regulation of neurogenesis;GO:0050793,biological_process regulation of developmental process;GO:0055008,biological_process cardiac muscle tissue morphogenesis;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060253,biological_process negative regulation of glial cell proliferation;GO:0060271,biological_process cilium morphogenesis;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0060411,biological_process cardiac septum morphogenesis;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060528,biological_process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060548,biological_process negative regulation of cell death;GO:0060740,biological_process prostate gland epithelium morphogenesis;GO:0060768,biological_process regulation of epithelial cell proliferation involved in prostate gland development;GO:0060842,biological_process arterial endothelial cell differentiation;GO:0060843,biological_process venous endothelial cell differentiation;GO:0060948,biological_process cardiac vascular smooth muscle cell development;GO:0060956,biological_process endocardial cell differentiation;GO:0060979,biological_process vasculogenesis involved in coronary vascular morphogenesis;GO:0060982,biological_process coronary artery morphogenesis;GO:0061314,biological_process Notch signaling involved in heart development;GO:0061384,biological_process heart trabecula morphogenesis;GO:0061419,biological_process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070986,biological_process left/right axis specification;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0071944,cellular_component cell periphery;GO:0072017,biological_process distal tubule development;GO:0072044,biological_process collecting duct development;GO:0072144,biological_process glomerular mesangial cell development;GO:0072602,biological_process interleukin-4 secretion;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097150,biological_process neuronal stem cell population maintenance;GO:1901201,biological_process regulation of extracellular matrix assembly;GO:1902263,biological_process apoptotic process involved in embryonic digit morphogenesis;GO:1903849,biological_process positive regulation of aorta morphogenesis;GO:2000737,biological_process negative regulation of stem cell differentiation;GO:2000811,biological_process negative regulation of anoikis;GO:2000974,biological_process negative regulation of pro-B cell differentiation;GO:2001027,biological_process negative regulation of endothelial cell chemotaxis	NOTCH1; Notch 1; K02599	notch 1 [Source:HGNC Symbol%3BAcc:HGNC:7881]
ENSG00000060762	29.87	34.93	27.13	28.95	29.56	29.32	0.0656214465530976	3.32548173138895	0.597819663994183	0.874781024581025	6:166364918-166383013:-	MPC1	14;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006850,biological_process mitochondrial pyruvate transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0050833,molecular_function pyruvate transmembrane transporter activity;GO:0061732,biological_process mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:1902361,biological_process mitochondrial pyruvate transmembrane transport;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	mitochondrial pyruvate carrier 1 [Source:HGNC Symbol%3BAcc:HGNC:21606]
ENSG00000173120	20.10	18.89	20.82	20.85	20.10	20.86	-0.0337409539652601	6.21322420709057	0.597822237293227	0.874781024581025	11:67119268-67258087:+	KDM2A	18;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0032259,biological_process methylation;GO:0032452,molecular_function histone demethylase activity;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation	NA	lysine demethylase 2A [Source:HGNC Symbol%3BAcc:HGNC:13606]
ENSG00000163964	22.40	20.28	17.55	19.90	20.95	22.31	-0.057051058401585	4.30431416673887	0.598031943478773	0.874984737671147	3:196639774-196736007:+	PIGX	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane	PIGX; GPI mannosyltransferase 1 subunit X; K07541	phosphatidylinositol glycan anchor biosynthesis class X [Source:HGNC Symbol%3BAcc:HGNC:26046]
ENSG00000166167	7.20	6.11	5.80	6.15	5.68	6.59	0.0677594626407309	3.5272858806504	0.598147036892941	0.875034283122664	10:101354032-101557321:+	BTRC	46;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007165,biological_process signal transduction;GO:0008013,molecular_function beta-catenin binding;GO:0016032,biological_process viral process;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030163,biological_process protein catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031648,biological_process protein destabilization;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042752,biological_process regulation of circadian rhythm;GO:0042753,biological_process positive regulation of circadian rhythm;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043687,biological_process post-translational protein modification;GO:0045309,molecular_function protein phosphorylated amino acid binding;GO:0045862,biological_process positive regulation of proteolysis;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051726,biological_process regulation of cell cycle;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071407,biological_process cellular response to organic cyclic compound	FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11; K03362	beta-transducin repeat containing E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:1144]
ENSG00000070761	38.06	43.74	42.20	44.10	44.41	40.56	-0.0501149272040985	4.61761810281927	0.598206793408437	0.875034283122664	16:58113587-58129450:-	CFAP20	17;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007275,biological_process multicellular organism development;GO:0018095,biological_process protein polyglutamylation;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0060296,biological_process regulation of cilium beat frequency involved in ciliary motility;GO:0070062,cellular_component extracellular exosome;GO:2000147,biological_process positive regulation of cell motility;GO:2000253,biological_process positive regulation of feeding behavior	NA	cilia and flagella associated protein 20 [Source:HGNC Symbol%3BAcc:HGNC:29523]
ENSG00000170634	13.16	13.57	13.72	14.38	10.34	14.06	0.0697780234423647	3.55826320846968	0.598367837735793	0.875125200323393	2:53970837-54305300:+	ACYP2	4;GO:0003998,molecular_function acylphosphatase activity;GO:0005515,molecular_function protein binding;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0016787,molecular_function hydrolase activity	acyP; acylphosphatase [EC:3.6.1.7]; K01512	acylphosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:180]
ENSG00000124406	5.59	7.38	5.87	6.03	6.67	5.43	0.0591210735682529	4.48445454269547	0.598409949274548	0.875125200323393	4:42408372-42657105:-	ATP8A1	32;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0007612,biological_process learning;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019829,molecular_function cation-transporting ATPase activity;GO:0030335,biological_process positive regulation of cell migration;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034220,biological_process ion transmembrane transport;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0042584,cellular_component chromaffin granule membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding;GO:0048194,biological_process Golgi vesicle budding;GO:0061092,biological_process positive regulation of phospholipid translocation;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	NA	ATPase phospholipid transporting 8A1 [Source:HGNC Symbol%3BAcc:HGNC:13531]
ENSG00000159692	62.47	66.49	70.11	69.49	68.97	67.15	-0.0350755868489698	7.1395698976195	0.598569474666628	0.875155411137283	4:1211447-1249953:-	CTBP1	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008152,biological_process metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016032,biological_process viral process;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016618,molecular_function hydroxypyruvate reductase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019079,biological_process viral genome replication;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation;GO:0030267,molecular_function glyoxylate reductase (NADP) activity;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0035067,biological_process negative regulation of histone acetylation;GO:0042803,molecular_function protein homodimerization activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0050872,biological_process white fat cell differentiation;GO:0051287,molecular_function NAD binding;GO:0051726,biological_process regulation of cell cycle;GO:0055114,biological_process oxidation-reduction process;GO:0070491,molecular_function repressing transcription factor binding;GO:0090241,biological_process negative regulation of histone H4 acetylation;GO:1903758,biological_process negative regulation of transcription from RNA polymerase II promoter by histone modification	CTBP; C-terminal binding protein; K04496	C-terminal binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2494]
ENSG00000074621	3.95	4.98	4.80	3.82	4.93	4.44	0.0642875813942805	3.95522819727749	0.598571613675625	0.875155411137283	15:65611365-65660995:+	SLC24A1	25;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007601,biological_process visual perception;GO:0008273,molecular_function calcium, potassium:sodium antiporter activity;GO:0009642,biological_process response to light intensity;GO:0015293,molecular_function symporter activity;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019867,cellular_component outer membrane;GO:0030955,molecular_function potassium ion binding;GO:0031402,molecular_function sodium ion binding;GO:0035725,biological_process sodium ion transmembrane transport;GO:0050896,biological_process response to stimulus;GO:0055085,biological_process transmembrane transport;GO:0060291,biological_process long-term synaptic potentiation;GO:0060292,biological_process long term synaptic depression;GO:0070588,biological_process calcium ion transmembrane transport	SLC24A1, NCKX1; solute carrier family 24 (sodium/potassium/calcium exchanger), member 1; K13749	solute carrier family 24 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10975]
ENSG00000100154	3.90	3.64	4.11	4.10	3.93	3.33	0.0528978377819269	4.868388342435	0.598704006602247	0.875245887875833	22:27978013-28679865:-	TTC28	10;GO:0000922,cellular_component spindle pole;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0030496,cellular_component midbody;GO:0051301,biological_process cell division	NA	tetratricopeptide repeat domain 28 [Source:HGNC Symbol%3BAcc:HGNC:29179]
ENSG00000152620	30.70	29.59	28.23	29.37	32.69	29.70	-0.0394929650274544	5.3924697215643	0.598918562718894	0.87545644359746	5:36192591-36242279:-	NADK2	12;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006741,biological_process NADP biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019674,biological_process NAD metabolic process;GO:0042803,molecular_function protein homodimerization activity	NA	NAD kinase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:26404]
ENSG00000114670	5.71	6.22	6.72	6.73	5.33	5.88	0.0658879125452085	3.69804049440234	0.599113937090491	0.87555052368968	3:131026849-131350465:+	NEK11	20;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016572,biological_process histone phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0035556,biological_process intracellular signal transduction;GO:0044772,biological_process mitotic cell cycle phase transition;GO:0046872,molecular_function metal ion binding;GO:1901990,biological_process regulation of mitotic cell cycle phase transition	NA	NIMA related kinase 11 [Source:HGNC Symbol%3BAcc:HGNC:18593]
ENSG00000101843	61.88	64.70	55.91	60.18	62.20	56.11	0.040994331215314	5.3543233932081	0.599195466471097	0.87555052368968	X:108084206-108091618:-	PSMD10	47;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006915,biological_process apoptotic process;GO:0007253,biological_process cytoplasmic sequestering of NF-kappaB;GO:0008134,molecular_function transcription factor binding;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0030307,biological_process positive regulation of cell growth;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0043488,biological_process regulation of mRNA stability;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043687,biological_process post-translational protein modification;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070682,biological_process proteasome regulatory particle assembly;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	NA	proteasome 26S subunit%2C non-ATPase 10 [Source:HGNC Symbol%3BAcc:HGNC:9555]
ENSG00000197070	22.80	25.01	22.67	23.37	22.35	23.27	0.0378256037691933	5.11927813487005	0.599246619622493	0.87555052368968	9:137605653-137615360:+	ARRDC1	4;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0070062,cellular_component extracellular exosome	NA	arrestin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28633]
ENSG00000117602	5.37	3.97	4.48	5.07	4.30	5.74	-0.105667590967129	1.87551855082791	0.599351198563619	0.87555052368968	1:24502350-24541040:+	RCAN3	11;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0008597,molecular_function calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0009653,biological_process anatomical structure morphogenesis;GO:0019722,biological_process calcium-mediated signaling;GO:0031013,molecular_function troponin I binding;GO:0050790,biological_process regulation of catalytic activity;GO:0070884,biological_process regulation of calcineurin-NFAT signaling cascade	NA	RCAN family member 3 [Source:HGNC Symbol%3BAcc:HGNC:3042]
ENSG00000133121	2.31	2.11	1.82	1.79	2.29	1.86	0.0835786308934721	2.92660565382188	0.599353255323906	0.87555052368968	13:33103134-33350630:-	STARD13	15;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0043542,biological_process endothelial cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:0097498,biological_process endothelial tube lumen extension	NA	StAR related lipid transfer domain containing 13 [Source:HGNC Symbol%3BAcc:HGNC:19164]
ENSG00000143742	373.81	365.20	346.80	381.31	365.85	372.69	-0.0329633707644921	7.27283338037727	0.599406134722863	0.87555052368968	1:225777812-225790466:+	SRP9	14;GO:0003723,molecular_function RNA binding;GO:0005047,molecular_function signal recognition particle binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005785,cellular_component signal recognition particle receptor complex;GO:0005786,cellular_component signal recognition particle, endoplasmic reticulum targeting;GO:0005829,cellular_component cytosol;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006616,biological_process SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0008312,molecular_function 7S RNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045900,biological_process negative regulation of translational elongation;GO:0048500,cellular_component signal recognition particle;GO:0070062,cellular_component extracellular exosome	SRP9; signal recognition particle subunit SRP9; K03109	signal recognition particle 9 [Source:HGNC Symbol%3BAcc:HGNC:11304]
ENSG00000103742	2.64	2.06	2.41	1.96	2.73	2.10	0.0908123094935942	3.14931452629271	0.599733306480614	0.875796980570752	15:65381463-65423072:-	IGDCC4	3;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	immunoglobulin superfamily DCC subclass member 4 [Source:HGNC Symbol%3BAcc:HGNC:13770]
ENSG00000007341	9.97	9.95	10.31	10.94	9.64	11.00	-0.0511893349130078	4.25375045782101	0.599740417748759	0.875796980570752	1:112523517-112620825:-	ST7L	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030308,biological_process negative regulation of cell growth	NA	suppression of tumorigenicity 7 like [Source:HGNC Symbol%3BAcc:HGNC:18441]
ENSG00000169884	2.06	3.02	1.53	2.18	1.89	1.87	0.133140030696929	1.39285024852208	0.599835428842047	0.875796980570752	12:48965339-48971763:-	WNT10B	50;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002062,biological_process chondrocyte differentiation;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0007050,biological_process cell cycle arrest;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0014835,biological_process myoblast differentiation involved in skeletal muscle regeneration;GO:0016055,biological_process Wnt signaling pathway;GO:0030182,biological_process neuron differentiation;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030858,biological_process positive regulation of epithelial cell differentiation;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0045165,biological_process cell fate commitment;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045778,biological_process positive regulation of ossification;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048018,molecular_function receptor agonist activity;GO:0048641,biological_process regulation of skeletal muscle tissue development;GO:0048741,biological_process skeletal muscle fiber development;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050821,biological_process protein stabilization;GO:0050909,biological_process sensory perception of taste;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051246,biological_process regulation of protein metabolic process;GO:0051885,biological_process positive regulation of anagen;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060346,biological_process bone trabecula formation;GO:0061196,biological_process fungiform papilla development;GO:0071300,biological_process cellular response to retinoic acid;GO:0071310,biological_process cellular response to organic substance;GO:0071320,biological_process cellular response to cAMP;GO:0071374,biological_process cellular response to parathyroid hormone stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:0071464,biological_process cellular response to hydrostatic pressure;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	WNT10; wingless-type MMTV integration site family, member 10; K01357	Wnt family member 10B [Source:HGNC Symbol%3BAcc:HGNC:12775]
ENSG00000197857	7.83	6.99	7.44	7.43	6.46	7.70	0.0591136880342665	3.98911542644831	0.599943486304908	0.875796980570752	19:12224685-12294887:-	ZNF44	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 44 [Source:HGNC Symbol%3BAcc:HGNC:13110]
ENSG00000135392	9.22	8.94	7.44	8.46	7.89	8.45	0.0550095604171671	4.15652525412309	0.59999462985875	0.875796980570752	12:55820959-55830824:-	DNAJC14	7;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	DnaJ heat shock protein family (Hsp40) member C14 [Source:HGNC Symbol%3BAcc:HGNC:24581]
ENSG00000161813	9.22	9.07	10.33	10.11	8.55	9.18	0.054466537003719	4.41268631163647	0.600024908358187	0.875796980570752	12:50392382-50480004:+	LARP4	14;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006412,biological_process translation;GO:0007010,biological_process cytoskeleton organization;GO:0008143,molecular_function poly(A) binding;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0022604,biological_process regulation of cell morphogenesis;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0045727,biological_process positive regulation of translation	NA	La ribonucleoprotein domain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:24320]
ENSG00000123545	13.05	18.38	19.07	17.97	15.02	21.16	-0.0977425807596388	3.21740371934041	0.600076431023398	0.875796980570752	6:96889312-96897881:-	NDUFAF4	8;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0010257,biological_process NADH dehydrogenase complex assembly;GO:0016020,cellular_component membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NA	NADH:ubiquinone oxidoreductase complex assembly factor 4 [Source:HGNC Symbol%3BAcc:HGNC:21034]
ENSG00000186001	12.41	13.86	14.27	13.54	14.67	13.85	-0.0438193484317525	5.1331396991474	0.600139298858843	0.875796980570752	3:197791225-197888436:+	LRCH3	7;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	leucine rich repeats and calponin homology domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28637]
ENSG00000189043	659.76	760.59	660.29	697.88	749.69	705.21	-0.0388810209550201	7.42309623679882	0.600545921791444	0.876287354789843	7:10931950-10940256:-	NDUFA4	16;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032403,molecular_function protein complex binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4; K03948	NDUFA4%2C mitochondrial complex associated [Source:HGNC Symbol%3BAcc:HGNC:7687]
ENSG00000203722	1.23	1.11	0.71	0.65	0.81	1.16	0.217895365355052	0.172933965779257	0.600806698349907	0.876395350444809	6:149916877-149923121:-	RAET1G	9;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031225,cellular_component anchored component of membrane;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0046703,molecular_function natural killer cell lectin-like receptor binding	RAET1; retinoic acid early transcript 1; K07987	retinoic acid early transcript 1G [Source:HGNC Symbol%3BAcc:HGNC:16795]
ENSG00000196371	4.18	3.73	3.98	4.38	3.96	4.33	-0.0752036783080965	2.74055403864345	0.600819985918524	0.876395350444809	11:94543839-94549898:+	FUT4	15;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008417,molecular_function fucosyltransferase activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0032580,cellular_component Golgi cisterna membrane;GO:0036065,biological_process fucosylation;GO:0042355,biological_process L-fucose catabolic process;GO:0046920,molecular_function alpha-(1->3)-fucosyltransferase activity;GO:0071944,cellular_component cell periphery	FUT4; galactoside alpha-1,3-fucosyltransferase 4 [EC:2.4.1.-]; K07632	fucosyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:4015]
ENSG00000135535	297.87	313.42	299.71	290.29	315.05	292.00	0.0331060082812646	7.73901758259825	0.600851272316528	0.876395350444809	6:109366513-109382457:-	CD164	19;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030097,biological_process hemopoiesis	CD164, MGC24; CD164 antigen; K06546	CD164 molecule [Source:HGNC Symbol%3BAcc:HGNC:1632]
ENSG00000271383	1.87	1.73	1.70	2.10	1.44	1.55	0.067940437420121	4.41776360639037	0.600943599236263	0.876395350444809	1:149390622-149556361:+	NBPF19	1;GO:0005737,cellular_component cytoplasm	NA	NBPF member 19 [Source:HGNC Symbol%3BAcc:HGNC:31999]
ENSG00000105325	24.35	28.19	27.30	26.11	28.14	28.50	-0.0440393582884004	5.33849946107995	0.600972949567889	0.876395350444809	19:3506272-3538330:+	FZR1	27;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010997,molecular_function anaphase-promoting complex binding;GO:0016567,biological_process protein ubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031965,cellular_component nuclear membrane;GO:0040020,biological_process regulation of meiotic nuclear division;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070306,biological_process lens fiber cell differentiation;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0090344,biological_process negative regulation of cell aging;GO:0097027,molecular_function ubiquitin-protein transferase activator activity;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity	CDH1; cell division cycle 20-like protein 1, cofactor of APC complex; K03364	fizzy and cell division cycle 20 related 1 [Source:HGNC Symbol%3BAcc:HGNC:24824]
ENSG00000130723	30.08	29.32	30.74	31.16	30.65	31.05	-0.030741651253239	7.67441817506188	0.601142960664412	0.87643512814028	9:131394092-131500197:+	PRRC2B	3;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0030154,biological_process cell differentiation	NA	proline rich coiled-coil 2B [Source:HGNC Symbol%3BAcc:HGNC:28121]
ENSG00000105287	17.07	15.51	15.26	16.81	13.42	16.45	0.0477255210359722	5.43616564873106	0.601145524518605	0.87643512814028	19:46674274-46717127:-	PRKD2	56;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0008219,biological_process cell death;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030949,biological_process positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0038033,biological_process positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045743,biological_process positive regulation of fibroblast growth factor receptor signaling pathway;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050862,biological_process positive regulation of T cell receptor signaling pathway;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0061154,biological_process endothelial tube morphogenesis;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0089700,biological_process protein kinase D signaling;GO:1901727,biological_process positive regulation of histone deacetylase activity;GO:1902533,biological_process positive regulation of intracellular signal transduction;GO:2000573,biological_process positive regulation of DNA biosynthetic process;GO:2001028,biological_process positive regulation of endothelial cell chemotaxis	PKD; protein kinase D [EC:2.7.11.13]; K06070	protein kinase D2 [Source:HGNC Symbol%3BAcc:HGNC:17293]
ENSG00000122432	1.23	1.11	1.18	1.47	1.71	0.87	-0.173989506316338	0.916570200787073	0.601212045123216	0.87643512814028	1:84506299-84566194:+	SPATA1	NA	NA	spermatogenesis associated 1 [Source:HGNC Symbol%3BAcc:HGNC:14682]
ENSG00000115944	161.21	162.44	173.89	180.98	160.85	172.71	-0.0363203817339607	6.43903576013302	0.601377387834355	0.876489215437332	2:42333545-42425088:-	COX7A2L	10;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	COX7A; cytochrome c oxidase subunit 7a; K02270	cytochrome c oxidase subunit 7A2 like [Source:HGNC Symbol%3BAcc:HGNC:2289]
ENSG00000144815	22.91	23.48	22.12	22.41	23.29	21.51	0.0379962945014886	5.25089079975616	0.601390368797209	0.876489215437332	3:101779201-101827392:+	NXPE3	1;GO:0005576,cellular_component extracellular region	NA	neurexophilin and PC-esterase domain family member 3 [Source:HGNC Symbol%3BAcc:HGNC:28238]
ENSG00000067191	4.03	4.10	5.06	5.26	3.66	5.21	-0.0861688957666917	3.25206389012883	0.601641430953527	0.876693645298498	17:39173455-39197703:-	CACNB1	17;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007528,biological_process neuromuscular junction development;GO:0008331,molecular_function high voltage-gated calcium channel activity;GO:0016020,cellular_component membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042383,cellular_component sarcolemma;GO:0061337,biological_process cardiac conduction;GO:0070588,biological_process calcium ion transmembrane transport;GO:1901385,biological_process regulation of voltage-gated calcium channel activity	CACNB1; voltage-dependent calcium channel beta-1; K04862	calcium voltage-gated channel auxiliary subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:1401]
ENSG00000173848	18.55	17.22	17.88	19.54	18.43	17.72	-0.0385460262479404	5.10761920504872	0.601671889494715	0.876693645298498	10:5412550-5458463:+	NET1	20;GO:0001558,biological_process regulation of cell growth;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0017049,molecular_function GTP-Rho binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051451,biological_process myoblast migration;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071479,biological_process cellular response to ionizing radiation;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	NA	neuroepithelial cell transforming 1 [Source:HGNC Symbol%3BAcc:HGNC:14592]
ENSG00000144048	21.80	19.36	22.66	20.26	22.22	19.97	0.0496770923394701	4.82612465489997	0.601884221231313	0.876808149186666	2:73762183-73780157:-	DUSP11	17;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0004651,molecular_function polynucleotide 5'-phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0006396,biological_process RNA processing;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016070,biological_process RNA metabolic process;GO:0016311,biological_process dephosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0045171,cellular_component intercellular bridge;GO:0098507,biological_process polynucleotide 5' dephosphorylation;GO:0098519,molecular_function nucleotide phosphatase activity, acting on free nucleotides	NA	dual specificity phosphatase 11 [Source:HGNC Symbol%3BAcc:HGNC:3066]
ENSG00000132646	112.03	141.94	106.88	112.83	125.44	112.71	0.0490028013221237	6.53796599464456	0.601908492390188	0.876808149186666	20:5114952-5126626:-	PCNA	65;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000701,molecular_function purine-specific mismatch base pair DNA N-glycosylase activity;GO:0000723,biological_process telomere maintenance;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005663,cellular_component DNA replication factor C complex;GO:0005813,cellular_component centrosome;GO:0006260,biological_process DNA replication;GO:0006266,biological_process DNA ligation;GO:0006272,biological_process leading strand elongation;GO:0006275,biological_process regulation of DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006979,biological_process response to oxidative stress;GO:0007507,biological_process heart development;GO:0008283,biological_process cell proliferation;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016925,biological_process protein sumoylation;GO:0019899,molecular_function enzyme binding;GO:0019985,biological_process translesion synthesis;GO:0030331,molecular_function estrogen receptor binding;GO:0030337,molecular_function DNA polymerase processivity factor activity;GO:0030855,biological_process epithelial cell differentiation;GO:0030894,cellular_component replisome;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031297,biological_process replication fork processing;GO:0032077,biological_process positive regulation of deoxyribonuclease activity;GO:0032139,molecular_function dinucleotide insertion or deletion binding;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0032355,biological_process response to estradiol;GO:0032405,molecular_function MutLalpha complex binding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0033993,biological_process response to lipid;GO:0034644,biological_process cellular response to UV;GO:0035035,molecular_function histone acetyltransferase binding;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042802,molecular_function identical protein binding;GO:0043596,cellular_component nuclear replication fork;GO:0043626,cellular_component PCNA complex;GO:0044849,biological_process estrous cycle;GO:0045739,biological_process positive regulation of DNA repair;GO:0045740,biological_process positive regulation of DNA replication;GO:0046686,biological_process response to cadmium ion;GO:0070062,cellular_component extracellular exosome;GO:0070182,molecular_function DNA polymerase binding;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070557,cellular_component PCNA-p21 complex;GO:0070987,biological_process error-free translesion synthesis;GO:0071548,biological_process response to dexamethasone;GO:0097421,biological_process liver regeneration;GO:1902065,biological_process response to L-glutamate;GO:1902990,biological_process mitotic telomere maintenance via semi-conservative replication	PCNA; proliferating cell nuclear antigen; K04802	proliferating cell nuclear antigen [Source:HGNC Symbol%3BAcc:HGNC:8729]
ENSG00000066855	30.70	31.55	30.14	30.24	32.54	32.79	-0.0392069189523505	5.27776854544314	0.601962381967998	0.876808149186666	8:65644733-65771261:+	MTFR1	6;GO:0000266,biological_process mitochondrial fission;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007005,biological_process mitochondrion organization;GO:0009060,biological_process aerobic respiration	NA	mitochondrial fission regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:29510]
ENSG00000156671	5.05	5.66	6.56	4.89	5.37	6.17	0.080578861174959	3.07220824166995	0.602245583901127	0.876927830991696	10:75099585-75182123:+	SAMD8	20;GO:0002950,molecular_function ceramide phosphoethanolamine synthase activity;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006686,biological_process sphingomyelin biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0033188,molecular_function sphingomyelin synthase activity;GO:0046513,biological_process ceramide biosynthetic process;GO:0047493,molecular_function ceramide cholinephosphotransferase activity;GO:1905373,biological_process ceramide phosphoethanolamine biosynthetic process;GO:2000303,biological_process regulation of ceramide biosynthetic process	NA	sterile alpha motif domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:26320]
ENSG00000152454	1.99	2.13	3.01	2.99	2.30	2.50	-0.108268984901856	2.27779298281141	0.602275750797732	0.876927830991696	19:57940832-57947675:-	ZNF256	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 256 [Source:HGNC Symbol%3BAcc:HGNC:13049]
ENSG00000134375	60.71	67.62	64.42	63.93	72.29	63.88	-0.045162640600772	5.07563117123971	0.602321837067034	0.876927830991696	1:201955490-201970661:+	TIMM17A	14;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0015450,molecular_function P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031305,cellular_component integral component of mitochondrial inner membrane	NA	translocase of inner mitochondrial membrane 17A [Source:HGNC Symbol%3BAcc:HGNC:17315]
ENSG00000244509	62.32	65.39	55.27	58.06	61.87	58.85	0.0413303313415227	5.10790168691976	0.602371294524676	0.876927830991696	22:39014082-39020352:+	APOBEC3C	17;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0009972,biological_process cytidine deamination;GO:0010529,biological_process negative regulation of transposition;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0016814,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0080111,biological_process DNA demethylation	NA	apolipoprotein B mRNA editing enzyme catalytic subunit 3C [Source:HGNC Symbol%3BAcc:HGNC:17353]
ENSG00000180992	116.25	108.31	103.72	113.77	115.59	110.41	-0.0365738801358862	5.60377450831222	0.602470145015719	0.876927830991696	6:44113453-44127457:-	MRPL14	10;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L14, MRPL14, rplN; large subunit ribosomal protein L14; K02874	mitochondrial ribosomal protein L14 [Source:HGNC Symbol%3BAcc:HGNC:14279]
ENSG00000164329	16.93	13.76	15.11	14.39	16.51	13.66	0.0590216662211077	4.46373250679833	0.602575621421483	0.876927830991696	5:79612119-79686648:+	PAPD4	18;GO:0000166,molecular_function nucleotide binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0004652,molecular_function polynucleotide adenylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0016740,molecular_function transferase activity;GO:0021766,biological_process hippocampus development;GO:0030182,biological_process neuron differentiation;GO:0031380,cellular_component nuclear RNA-directed RNA polymerase complex;GO:0043631,biological_process RNA polyadenylation;GO:0046872,molecular_function metal ion binding;GO:0060041,biological_process retina development in camera-type eye;GO:0071044,biological_process histone mRNA catabolic process;GO:1990603,biological_process dark adaptation	NA	poly(A) RNA polymerase D4%2C non-canonical [Source:HGNC Symbol%3BAcc:HGNC:26776]
ENSG00000172530	6.14	8.20	8.60	7.20	8.73	8.34	-0.0753376719859001	3.78632991829974	0.602678906937479	0.876927830991696	16:87949243-88077318:+	BANP	15;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0016569,biological_process covalent chromatin modification;GO:0016604,cellular_component nuclear body;GO:0034504,biological_process protein localization to nucleus;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	BTG3 associated nuclear protein [Source:HGNC Symbol%3BAcc:HGNC:13450]
ENSG00000123983	112.31	120.12	104.71	113.21	123.63	111.83	-0.0374104346178033	7.94916872829328	0.602697164910307	0.876927830991696	2:222860933-222944639:+	ACSL3	35;GO:0000166,molecular_function nucleotide binding;GO:0001676,biological_process long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0004467,molecular_function long-chain fatty acid-CoA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0007420,biological_process brain development;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0031090,cellular_component organelle membrane;GO:0034379,biological_process very-low-density lipoprotein particle assembly;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0042998,biological_process positive regulation of Golgi to plasma membrane protein transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044539,biological_process long-chain fatty acid import;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051047,biological_process positive regulation of secretion;GO:0102391,molecular_function decanoate--CoA ligase activity;GO:2001247,biological_process positive regulation of phosphatidylcholine biosynthetic process	ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]; K01897	acyl-CoA synthetase long chain family member 3 [Source:HGNC Symbol%3BAcc:HGNC:3570]
ENSG00000204438	15.41	17.18	15.23	17.95	15.05	16.92	-0.0573124901269657	4.13210699044171	0.602777451049933	0.876927830991696	6:31661228-31666283:-	GPANK1	2;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding	NA	G-patch domain and ankyrin repeats 1 [Source:HGNC Symbol%3BAcc:HGNC:13920]
ENSG00000153551	22.40	19.28	19.50	22.56	18.15	23.75	-0.0616692422313586	4.12477668699023	0.602904886196171	0.876927830991696	3:32391670-32483067:+	CMTM7	6;GO:0002337,biological_process B-1a B cell differentiation;GO:0005125,molecular_function cytokine activity;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CKLF like MARVEL transmembrane domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:19178]
ENSG00000152056	44.81	50.81	45.11	44.94	46.68	46.05	0.0378871600886882	5.19664027147514	0.602941936322721	0.876927830991696	2:223751685-223838027:-	AP1S3	21;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005905,cellular_component clathrin-coated pit;GO:0006605,biological_process protein targeting;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030117,cellular_component membrane coat;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050690,biological_process regulation of defense response to virus by virus	AP1S3; AP-1 complex subunit sigma-3; K12395	adaptor related protein complex 1 sigma 3 subunit [Source:HGNC Symbol%3BAcc:HGNC:18971]
ENSG00000107341	100.10	96.10	96.79	100.77	94.33	107.74	-0.035766523484591	6.1524499688366	0.602954688363541	0.876927830991696	9:33817566-33920404:+	UBE2R2	14;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006513,biological_process protein monoubiquitination;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070936,biological_process protein K48-linked ubiquitination	NA	ubiquitin conjugating enzyme E2 R2 [Source:HGNC Symbol%3BAcc:HGNC:19907]
ENSG00000213906	3.81	4.09	4.10	3.66	4.09	5.18	-0.102459014892827	2.32596589069818	0.602962945099019	0.876927830991696	14:24305733-24312053:+	LTB4R2	18;GO:0001632,molecular_function leukotriene B4 receptor activity;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004974,molecular_function leukotriene receptor activity;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006935,biological_process chemotaxis;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007194,biological_process negative regulation of adenylate cyclase activity;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0008528,molecular_function G-protein coupled peptide receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051546,biological_process keratinocyte migration;GO:0061737,biological_process leukotriene signaling pathway	LTB4R2; leukotriene B4 receptor 2; K04297	leukotriene B4 receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:19260]
ENSG00000100739	1.85	1.59	2.64	1.64	2.19	1.72	0.163418068837238	1.25135409591311	0.603148025620411	0.877068937128691	14:96255823-96268967:+	BDKRB1	26;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004947,molecular_function bradykinin receptor activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006950,biological_process response to stress;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0009612,biological_process response to mechanical stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0019233,biological_process sensory perception of pain;GO:0030308,biological_process negative regulation of cell growth;GO:0032496,biological_process response to lipopolysaccharide;GO:0042277,molecular_function peptide binding;GO:0043005,cellular_component neuron projection;GO:0045776,biological_process negative regulation of blood pressure;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol	BDKRB1; bradykinin receptor B1; K03915	bradykinin receptor B1 [Source:HGNC Symbol%3BAcc:HGNC:1029]
ENSG00000107796	6.37	4.65	4.62	5.83	4.83	4.10	0.106808703395476	2.56076087525131	0.603201282225701	0.877068937128691	10:88935073-88991339:-	ACTA2	21;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006936,biological_process muscle contraction;GO:0008217,biological_process regulation of blood pressure;GO:0009615,biological_process response to virus;GO:0010628,biological_process positive regulation of gene expression;GO:0014829,biological_process vascular smooth muscle contraction;GO:0015629,cellular_component actin cytoskeleton;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0030485,cellular_component smooth muscle contractile fiber;GO:0043234,cellular_component protein complex;GO:0044297,cellular_component cell body;GO:0070062,cellular_component extracellular exosome;GO:0072144,biological_process glomerular mesangial cell development;GO:0090131,biological_process mesenchyme migration	ACTA2; actin, aortic smooth muscle; K12313	actin%2C alpha 2%2C smooth muscle%2C aorta [Source:HGNC Symbol%3BAcc:HGNC:130]
ENSG00000228486	1.73	1.27	1.96	1.45	1.63	2.52	-0.148420791531439	0.924698649484643	0.603421060051353	0.877229263590881	2:97664216-97703064:+	LINC01125	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	long intergenic non-protein coding RNA 1125 [Source:HGNC Symbol%3BAcc:HGNC:49272]
ENSG00000167395	6.95	7.88	6.30	6.77	6.62	7.21	0.0423140654092888	5.28855746099126	0.60348810885562	0.877229263590881	16:31074421-31084196:+	ZNF646	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 646 [Source:HGNC Symbol%3BAcc:HGNC:29004]
ENSG00000188501	3.40	4.05	3.03	3.57	3.21	3.10	0.083649824070875	2.55728882338942	0.603523556840902	0.877229263590881	15:66547178-66565979:-	LCTL	9;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005903,cellular_component brush border;GO:0005975,biological_process carbohydrate metabolic process;GO:0008422,molecular_function beta-glucosidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1901657,biological_process glycosyl compound metabolic process	NA	lactase like [Source:HGNC Symbol%3BAcc:HGNC:15583]
ENSG00000164031	20.03	18.98	18.12	20.34	20.36	18.77	-0.0444338310263886	4.62270014049504	0.603710685675118	0.877398517888449	4:99896247-99946726:-	DNAJB14	10;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030544,molecular_function Hsp70 protein binding;GO:0031965,cellular_component nuclear membrane;GO:0043623,biological_process cellular protein complex assembly;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0070389,biological_process chaperone cofactor-dependent protein refolding	NA	DnaJ heat shock protein family (Hsp40) member B14 [Source:HGNC Symbol%3BAcc:HGNC:25881]
ENSG00000108055	33.37	32.88	31.67	33.22	32.95	34.80	-0.0329108402602375	6.92189736382016	0.603972547831313	0.877647950724835	10:110567690-110604636:+	SMC3	39;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0000800,cellular_component lateral element;GO:0003682,molecular_function chromatin binding;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005604,cellular_component basement membrane;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006275,biological_process regulation of DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0008278,cellular_component cohesin complex;GO:0016363,cellular_component nuclear matrix;GO:0019827,biological_process stem cell population maintenance;GO:0030893,cellular_component meiotic cohesin complex;GO:0032403,molecular_function protein complex binding;GO:0032876,biological_process negative regulation of DNA endoreduplication;GO:0034991,cellular_component nuclear meiotic cohesin complex;GO:0036033,molecular_function mediator complex binding;GO:0044791,biological_process positive regulation by host of viral release from host cell;GO:0046982,molecular_function protein heterodimerization activity;GO:0048487,molecular_function beta-tubulin binding;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051702,biological_process interaction with symbiont;GO:0070840,molecular_function dynein complex binding;GO:0097431,cellular_component mitotic spindle pole	NA	structural maintenance of chromosomes 3 [Source:HGNC Symbol%3BAcc:HGNC:2468]
ENSG00000100403	48.55	46.79	52.23	50.94	48.67	52.85	-0.0343824969981386	7.19835989432896	0.604023720538328	0.877647950724835	22:41301521-41360147:+	ZC3H7B	6;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016032,biological_process viral process;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 7B [Source:HGNC Symbol%3BAcc:HGNC:30869]
ENSG00000160199	14.58	16.15	17.33	15.28	15.77	15.75	0.0478911512090554	4.38044088732726	0.604309120521977	0.877920384714176	21:42974509-43033931:+	PKNOX1	20;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030097,biological_process hemopoiesis;GO:0030217,biological_process T cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0043010,biological_process camera-type eye development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity	NA	PBX/knotted 1 homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:9022]
ENSG00000152684	16.69	19.03	14.34	18.09	15.43	19.00	-0.0658010015293849	4.31204914894229	0.604352669570824	0.877920384714176	5:52787939-52804046:+	PELO	23;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006412,biological_process translation;GO:0007049,biological_process cell cycle;GO:0007492,biological_process endoderm development;GO:0008283,biological_process cell proliferation;GO:0016787,molecular_function hydrolase activity;GO:0019827,biological_process stem cell population maintenance;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0032790,biological_process ribosome disassembly;GO:0043022,molecular_function ribosome binding;GO:0046872,molecular_function metal ion binding;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0060231,biological_process mesenchymal to epithelial transition;GO:0070481,biological_process nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0070651,biological_process nonfunctional rRNA decay;GO:0070966,biological_process nuclear-transcribed mRNA catabolic process, no-go decay;GO:0071025,biological_process RNA surveillance;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	PELO, DOM34, pelA; protein pelota; K06965	pelota mRNA surveillance and ribosome rescue factor [Source:HGNC Symbol%3BAcc:HGNC:8829]
ENSG00000185298	19.49	19.01	19.33	18.82	16.27	20.90	0.0568173520031263	4.10039311097689	0.604726472213142	0.878360601402028	17:81666363-81673904:+	CCDC137	5;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus	NA	coiled-coil domain containing 137 [Source:HGNC Symbol%3BAcc:HGNC:33451]
ENSG00000116353	22.01	18.50	21.28	21.23	17.61	21.35	0.0547144927319071	4.67474075470327	0.604919439832784	0.878538084315474	1:29192872-29230942:-	MECR	11;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0016491,molecular_function oxidoreductase activity;GO:0019166,molecular_function trans-2-enoyl-CoA reductase (NADPH) activity;GO:0055114,biological_process oxidation-reduction process	MECR, NRBF1; mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38]; K07512	mitochondrial trans-2-enoyl-CoA reductase [Source:HGNC Symbol%3BAcc:HGNC:19691]
ENSG00000079257	33.94	32.23	33.95	33.95	33.90	36.16	-0.0413385889441345	4.72965457703168	0.605077525042752	0.878623875257819	3:158645821-158672693:-	LXN	11;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006954,biological_process inflammatory response;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0008201,molecular_function heparin binding;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain;GO:0070062,cellular_component extracellular exosome	NA	latexin [Source:HGNC Symbol%3BAcc:HGNC:13347]
ENSG00000103254	9.20	8.34	7.86	8.48	7.41	8.33	0.0813014506907866	2.7026084946985	0.60516517478011	0.878623875257819	16:720580-722601:+	FAM173A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 173 member A [Source:HGNC Symbol%3BAcc:HGNC:14152]
ENSG00000186714	0.26	0.17	0.47	0.18	0.28	0.32	0.250479341003215	0.122767552308743	0.605276471117858	0.878623875257819	11:32602245-32794658:-	CCDC73	NA	NA	coiled-coil domain containing 73 [Source:HGNC Symbol%3BAcc:HGNC:23261]
ENSG00000148429	7.74	7.16	7.32	7.56	7.26	8.36	-0.0481262439083369	4.35788283384708	0.605278998628575	0.878623875257819	10:11453945-11611754:-	USP6NL	17;GO:0005096,molecular_function GTPase activator activity;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0007030,biological_process Golgi organization;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0019068,biological_process virion assembly;GO:0031338,biological_process regulation of vesicle fusion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035526,biological_process retrograde transport, plasma membrane to Golgi;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048227,biological_process plasma membrane to endosome transport;GO:0090630,biological_process activation of GTPase activity;GO:1903358,biological_process regulation of Golgi organization	NA	USP6 N-terminal like [Source:HGNC Symbol%3BAcc:HGNC:16858]
ENSG00000005700	44.60	49.05	44.62	45.30	49.15	48.29	-0.0351936441825488	7.58994496095512	0.605332424168603	0.878623875257819	6:82169982-82247754:-	IBTK	9;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030292,molecular_function protein tyrosine kinase inhibitor activity;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity	NA	inhibitor of Bruton tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:17853]
ENSG00000120910	6.54	5.70	5.79	6.63	5.00	5.70	0.0730826763277253	3.37245220231241	0.605473054202405	0.878725245155437	8:22440818-22541142:+	PPP3CC	11;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007420,biological_process brain development;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]; K04348	protein phosphatase 3 catalytic subunit gamma [Source:HGNC Symbol%3BAcc:HGNC:9316]
ENSG00000004777	4.74	4.61	5.32	4.59	4.81	4.90	0.0517991999771661	4.27091562652545	0.605712472439534	0.878810834915185	19:35774531-35788822:+	ARHGAP33	16;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0019901,molecular_function protein kinase binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 33 [Source:HGNC Symbol%3BAcc:HGNC:23085]
ENSG00000213523	25.06	24.74	22.77	23.26	24.32	28.15	-0.0529255706947576	4.30361950365543	0.605729129458217	0.878810834915185	5:140537339-140558252:-	SRA1	19;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0008283,biological_process cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030154,biological_process cell differentiation;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042981,biological_process regulation of apoptotic process;GO:0045171,cellular_component intercellular bridge;GO:2000273,biological_process positive regulation of receptor activity	NA	steroid receptor RNA activator 1 [Source:HGNC Symbol%3BAcc:HGNC:11281]
ENSG00000143314	101.80	108.25	97.79	104.91	105.34	107.32	-0.0359786059698732	6.08112021297481	0.60574442145608	0.878810834915185	1:156737302-156741590:-	MRPL24	10;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L24, MRPL24, rplX; large subunit ribosomal protein L24; K02895	mitochondrial ribosomal protein L24 [Source:HGNC Symbol%3BAcc:HGNC:14037]
ENSG00000144063	5.25	4.23	5.21	4.11	2.28	6.72	0.175448051916095	1.48358847052739	0.606089412143064	0.878969405207368	2:110083869-110116566:-	MALL	13;GO:0000139,cellular_component Golgi membrane;GO:0001766,biological_process membrane raft polarization;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0008104,biological_process protein localization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019911,molecular_function structural constituent of myelin sheath;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042552,biological_process myelination;GO:0042632,biological_process cholesterol homeostasis;GO:0045121,cellular_component membrane raft	NA	mal%2C T-cell differentiation protein like [Source:HGNC Symbol%3BAcc:HGNC:6818]
ENSG00000110497	8.43	8.57	8.30	7.27	8.73	8.72	0.0437704662230841	5.0275547016732	0.606118282964124	0.878969405207368	11:46396413-46594125:-	AMBRA1	29;GO:0000045,biological_process autophagosome assembly;GO:0000422,biological_process mitophagy;GO:0000423,biological_process macromitophagy;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006914,biological_process autophagy;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009267,biological_process cellular response to starvation;GO:0010508,biological_process positive regulation of autophagy;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0016236,biological_process macroautophagy;GO:0021915,biological_process neural tube development;GO:0030154,biological_process cell differentiation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031667,biological_process response to nutrient levels;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045335,cellular_component phagocytic vesicle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051020,molecular_function GTPase binding;GO:0098780,biological_process response to mitochondrial depolarisation	NA	autophagy and beclin 1 regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:25990]
ENSG00000120458	9.64	10.54	9.87	9.55	10.18	9.48	0.0488702497235614	4.06112459607868	0.606165493566218	0.878969405207368	11:124766497-124800673:-	MSANTD2	NA	NA	Myb/SANT DNA binding domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26266]
ENSG00000077238	24.55	23.51	24.78	24.46	22.54	24.74	0.0348013707541412	6.13675987214044	0.606321738335684	0.878969405207368	16:27313667-27364778:+	IL4R	30;GO:0002376,biological_process immune system process;GO:0002532,biological_process production of molecular mediator involved in inflammatory response;GO:0002639,biological_process positive regulation of immunoglobulin production;GO:0004896,molecular_function cytokine receptor activity;GO:0004913,molecular_function interleukin-4 receptor activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016064,biological_process immunoglobulin mediated immune response;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030728,biological_process ovulation;GO:0035771,biological_process interleukin-4-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042832,biological_process defense response to protozoan;GO:0043032,biological_process positive regulation of macrophage activation;GO:0043235,cellular_component receptor complex;GO:0043306,biological_process positive regulation of mast cell degranulation;GO:0043627,biological_process response to estrogen;GO:0045626,biological_process negative regulation of T-helper 1 cell differentiation;GO:0045630,biological_process positive regulation of T-helper 2 cell differentiation;GO:0090197,biological_process positive regulation of chemokine secretion;GO:1901741,biological_process positive regulation of myoblast fusion;GO:1990834,biological_process response to odorant	IL4R, CD124; interleukin 4 receptor; K05071	interleukin 4 receptor [Source:HGNC Symbol%3BAcc:HGNC:6015]
ENSG00000167792	86.26	92.28	85.94	88.71	93.36	90.66	-0.0338345714074772	7.02755999147559	0.606513649281169	0.878969405207368	11:67606851-67612535:+	NDUFV1	19;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005829,cellular_component cytosol;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0010181,molecular_function FMN binding;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0042775,biological_process mitochondrial ATP synthesis coupled electron transport;GO:0046872,molecular_function metal ion binding;GO:0051287,molecular_function NAD binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2 1.6.99.3]; K03942	NADH:ubiquinone oxidoreductase core subunit V1 [Source:HGNC Symbol%3BAcc:HGNC:7716]
ENSG00000144580	28.23	28.11	29.92	29.73	29.20	30.41	-0.0379313036132987	5.08851577240057	0.606528965813192	0.878969405207368	2:218568579-218597080:+	CNOT9	28;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006402,biological_process mRNA catabolic process;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007548,biological_process sex differentiation;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019900,molecular_function kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030014,cellular_component CCR4-NOT complex;GO:0030015,cellular_component CCR4-NOT core complex;GO:0031047,biological_process gene silencing by RNA;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:2000327,biological_process positive regulation of ligand-dependent nuclear receptor transcription coactivator activity	RCD1, CNOT9, CAF40; CCR4-NOT transcription complex subunit 9; K12606	CCR4-NOT transcription complex subunit 9 [Source:HGNC Symbol%3BAcc:HGNC:10445]
ENSG00000143878	76.03	99.30	72.47	63.16	104.86	67.57	0.082853369994679	5.56538360530639	0.606662570488772	0.878969405207368	2:20447073-20449445:+	RHOB	41;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0001525,biological_process angiogenesis;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006915,biological_process apoptotic process;GO:0007155,biological_process cell adhesion;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008333,biological_process endosome to lysosome transport;GO:0010008,cellular_component endosome membrane;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0030334,biological_process regulation of cell migration;GO:0030336,biological_process negative regulation of cell migration;GO:0031902,cellular_component late endosome membrane;GO:0032154,cellular_component cleavage furrow;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045786,biological_process negative regulation of cell cycle;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0061154,biological_process endothelial tube morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071479,biological_process cellular response to ionizing radiation	NA	ras homolog family member B [Source:HGNC Symbol%3BAcc:HGNC:668]
ENSG00000126883	10.58	11.95	11.13	11.19	12.27	11.34	-0.0381249026280995	6.25032251875495	0.606838994302478	0.878969405207368	9:131125560-131234670:+	NUP214	33;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006110,biological_process regulation of glycolytic process;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008139,molecular_function nuclear localization sequence binding;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043488,biological_process regulation of mRNA stability;GO:0043657,cellular_component host cell;GO:0044613,cellular_component nuclear pore central transport channel;GO:0044615,cellular_component nuclear pore nuclear basket;GO:0051028,biological_process mRNA transport;GO:0051726,biological_process regulation of cell cycle;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat;GO:1990876,cellular_component cytoplasmic side of nuclear pore	NUP214, CAN; nuclear pore complex protein Nup214; K14317	nucleoporin 214 [Source:HGNC Symbol%3BAcc:HGNC:8064]
ENSG00000186409	1.37	1.16	1.43	1.12	1.14	1.43	0.126086609476792	1.7297763308677	0.60691833274281	0.878969405207368	1:42463329-42654664:+	CCDC30	1;GO:0070062,cellular_component extracellular exosome	NA	coiled-coil domain containing 30 [Source:HGNC Symbol%3BAcc:HGNC:26103]
ENSG00000197124	1.27	2.26	1.78	1.81	2.40	1.66	-0.15578936821247	1.64166366368837	0.60694116953727	0.878969405207368	19:19997057-20039506:-	ZNF682	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 682 [Source:HGNC Symbol%3BAcc:HGNC:28857]
ENSG00000253797	5.26	5.32	5.16	5.05	6.44	5.11	-0.0644390605208737	3.64768488672997	0.606961985349758	0.878969405207368	13:52024690-52033600:+	UTP14C	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0030490,biological_process maturation of SSU-rRNA;GO:0032040,cellular_component small-subunit processome;GO:0042254,biological_process ribosome biogenesis;GO:0051321,biological_process meiotic cell cycle	UTP14; U3 small nucleolar RNA-associated protein 14; K14567	UTP14C%2C small subunit processome component [Source:HGNC Symbol%3BAcc:HGNC:20321]
ENSG00000110536	27.18	27.92	28.01	29.76	26.84	29.92	-0.0483707462808278	4.34343241422583	0.607012336918195	0.878969405207368	11:47565429-47573461:+	PTPMT1	19;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006655,biological_process phosphatidylglycerol biosynthetic process;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0008962,molecular_function phosphatidylglycerophosphatase activity;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0032049,biological_process cardiolipin biosynthetic process;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation	NA	protein tyrosine phosphatase%2C mitochondrial 1 [Source:HGNC Symbol%3BAcc:HGNC:26965]
ENSG00000114491	17.77	18.16	16.64	20.21	15.75	18.89	-0.0523799423957761	4.78077150504447	0.607032037614704	0.878969405207368	3:124730365-124749273:+	UMPS	20;GO:0003824,molecular_function catalytic activity;GO:0004588,molecular_function orotate phosphoribosyltransferase activity;GO:0004590,molecular_function orotidine-5'-phosphate decarboxylase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006207,biological_process 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0006222,biological_process UMP biosynthetic process;GO:0007565,biological_process female pregnancy;GO:0007595,biological_process lactation;GO:0008152,biological_process metabolic process;GO:0009116,biological_process nucleoside metabolic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0035690,biological_process cellular response to drug;GO:0044205,biological_process 'de novo' UMP biosynthetic process;GO:0046134,biological_process pyrimidine nucleoside biosynthetic process	UMPS; uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23]; K13421	uridine monophosphate synthetase [Source:HGNC Symbol%3BAcc:HGNC:12563]
ENSG00000108578	35.51	36.77	36.80	36.05	37.66	38.87	-0.0352107311745141	5.75617138488446	0.607130089334136	0.878969405207368	17:30248194-30292056:-	BLMH	17;GO:0000209,biological_process protein polyubiquitination;GO:0004177,molecular_function aminopeptidase activity;GO:0004180,molecular_function carboxypeptidase activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0009636,biological_process response to toxic substance;GO:0016787,molecular_function hydrolase activity;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0043418,biological_process homocysteine catabolic process;GO:0070062,cellular_component extracellular exosome	NA	bleomycin hydrolase [Source:HGNC Symbol%3BAcc:HGNC:1059]
ENSG00000110455	11.56	10.24	11.56	11.76	10.90	9.78	0.0597797759427943	4.05850139955943	0.607160693109344	0.878969405207368	11:44065924-44084222:+	ACCS	6;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0009058,biological_process biosynthetic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity	NA	1-aminocyclopropane-1-carboxylate synthase homolog (inactive) [Source:HGNC Symbol%3BAcc:HGNC:23989]
ENSG00000129680	18.35	20.42	19.54	18.21	20.71	18.22	0.0390600342606216	5.67240900461024	0.607180994450906	0.878969405207368	X:136213219-136256482:-	MAP7D3	10;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005198,molecular_function structural molecule activity;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0046785,biological_process microtubule polymerization	NA	MAP7 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25742]
ENSG00000135823	21.97	17.36	19.34	17.91	18.54	20.50	0.062767539536838	3.90260222534905	0.607218102524149	0.878969405207368	1:180972711-181023121:-	STX6	33;GO:0000139,cellular_component Golgi membrane;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006906,biological_process vesicle fusion;GO:0007032,biological_process endosome organization;GO:0008021,cellular_component synaptic vesicle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0032456,biological_process endocytic recycling;GO:0032588,cellular_component trans-Golgi network membrane;GO:0032880,biological_process regulation of protein localization;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043195,cellular_component terminal bouton;GO:0045335,cellular_component phagocytic vesicle;GO:0048193,biological_process Golgi vesicle transport;GO:0048278,biological_process vesicle docking;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090161,biological_process Golgi ribbon formation;GO:1903827,biological_process regulation of cellular protein localization	STX6; syntaxin 6; K08498	syntaxin 6 [Source:HGNC Symbol%3BAcc:HGNC:11441]
ENSG00000204186	3.06	2.81	3.13	3.06	2.89	2.85	0.0501231018093919	4.41222946160409	0.607281074186205	0.878969405207368	2:206274662-206314428:+	ZDBF2	3;GO:0003676,molecular_function nucleic acid binding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger DBF-type containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29313]
ENSG00000181555	20.03	19.33	20.28	19.16	19.99	19.70	0.0316878974852764	7.25993737886814	0.607331773603451	0.878969405207368	3:47016428-47163967:-	SETD2	35;GO:0001525,biological_process angiogenesis;GO:0001570,biological_process vasculogenesis;GO:0001763,biological_process morphogenesis of a branching structure;GO:0001843,biological_process neural tube closure;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006298,biological_process mismatch repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008168,molecular_function methyltransferase activity;GO:0010452,biological_process histone H3-K36 methylation;GO:0010468,biological_process regulation of gene expression;GO:0010793,biological_process regulation of mRNA export from nucleus;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018023,biological_process peptidyl-lysine trimethylation;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030900,biological_process forebrain development;GO:0032259,biological_process methylation;GO:0034728,biological_process nucleosome organization;GO:0034968,biological_process histone lysine methylation;GO:0035441,biological_process cell migration involved in vasculogenesis;GO:0046975,molecular_function histone methyltransferase activity (H3-K36 specific);GO:0048332,biological_process mesoderm morphogenesis;GO:0048568,biological_process embryonic organ development;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048864,biological_process stem cell development;GO:0060039,biological_process pericardium development;GO:0060669,biological_process embryonic placenta morphogenesis;GO:0060977,biological_process coronary vasculature morphogenesis;GO:0097198,biological_process histone H3-K36 trimethylation;GO:0097676,biological_process histone H3-K36 dimethylation	SETD2; [histone H3]-dimethyl-L-lysine36 N-methyltransferase [EC:2.1.1.358]; K11423	SET domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18420]
ENSG00000122085	13.42	15.21	15.29	15.17	15.02	15.42	-0.0467256844434254	4.71238067375996	0.607363154734889	0.878969405207368	2:241072168-241102332:-	MTERF4	19;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0006626,biological_process protein targeting to mitochondrion;GO:0007507,biological_process heart development;GO:0008380,biological_process RNA splicing;GO:0019843,molecular_function rRNA binding;GO:0031167,biological_process rRNA methylation;GO:0032502,biological_process developmental process;GO:0042255,biological_process ribosome assembly;GO:0043010,biological_process camera-type eye development	NA	mitochondrial transcription termination factor 4 [Source:HGNC Symbol%3BAcc:HGNC:28785]
ENSG00000205730	8.17	8.50	7.70	7.70	7.30	8.56	0.054146449636433	3.85897209297839	0.6073732870946	0.878969405207368	16:19113931-19121629:+	ITPRIPL2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	inositol 1%2C4%2C5-trisphosphate receptor interacting protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:27257]
ENSG00000138073	21.87	22.95	21.96	22.39	21.82	21.19	0.0394332249060795	4.87332751409495	0.607411549010618	0.878969405207368	2:27130755-27134675:-	PREB	26;GO:0000139,cellular_component Golgi membrane;GO:0003400,biological_process regulation of COPII vesicle coating;GO:0003677,molecular_function DNA binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005090,molecular_function Sar guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0009306,biological_process protein secretion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0032527,biological_process protein exit from endoplasmic reticulum;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048208,biological_process COPII vesicle coating;GO:0051020,molecular_function GTPase binding;GO:0070971,cellular_component endoplasmic reticulum exit site	PREB, SEC12; prolactin regulatory element-binding protein; K14003	prolactin regulatory element binding [Source:HGNC Symbol%3BAcc:HGNC:9356]
ENSG00000163762	197.47	212.37	187.48	186.87	212.56	186.58	0.038146768402573	6.89574895071547	0.607512306026317	0.87899667777958	3:149318497-149334414:-	TM4SF18	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane 4 L six family member 18 [Source:HGNC Symbol%3BAcc:HGNC:25181]
ENSG00000124164	53.67	59.12	56.74	57.41	55.97	52.86	0.0372746739317623	5.35490584210629	0.607646116465057	0.87899667777958	20:58389121-58451101:+	VAPB	26;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006986,biological_process response to unfolded protein;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0007029,biological_process endoplasmic reticulum organization;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019048,biological_process modulation by virus of host morphology or physiology;GO:0019899,molecular_function enzyme binding;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0033149,molecular_function FFAT motif binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045296,molecular_function cadherin binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048487,molecular_function beta-tubulin binding;GO:0090114,biological_process COPII-coated vesicle budding	VAPB, ALS8; vesicle-associated membrane protein-associated protein B; K10707	VAMP associated protein B and C [Source:HGNC Symbol%3BAcc:HGNC:12649]
ENSG00000122483	6.93	7.52	6.69	6.80	7.80	7.34	-0.0454195413817306	5.0306347413695	0.607686451729393	0.87899667777958	1:93179918-93278730:+	CCDC18	NA	NA	coiled-coil domain containing 18 [Source:HGNC Symbol%3BAcc:HGNC:30370]
ENSG00000095380	32.59	40.53	35.05	37.01	37.49	37.63	-0.0469150328756236	5.40690457138149	0.60778922222843	0.87899667777958	9:98056738-98083075:+	NANS	10;GO:0003824,molecular_function catalytic activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006055,biological_process CMP-N-acetylneuraminate biosynthetic process;GO:0008781,molecular_function N-acylneuraminate cytidylyltransferase activity;GO:0016051,biological_process carbohydrate biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0047444,molecular_function N-acylneuraminate-9-phosphate synthase activity;GO:0050462,molecular_function N-acetylneuraminate synthase activity;GO:0070062,cellular_component extracellular exosome	NANS, SAS; sialic acid synthase [EC:2.5.1.56 2.5.1.57 2.5.1.132]; K05304	N-acetylneuraminate synthase [Source:HGNC Symbol%3BAcc:HGNC:19237]
ENSG00000196712	14.38	14.13	14.94	14.43	14.06	14.37	0.0320225374950963	7.05661361524464	0.60784433679465	0.87899667777958	17:31094926-31382116:+	NF1	90;GO:0000165,biological_process MAPK cascade;GO:0001649,biological_process osteoblast differentiation;GO:0001656,biological_process metanephros development;GO:0001666,biological_process response to hypoxia;GO:0001889,biological_process liver development;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007154,biological_process cell communication;GO:0007165,biological_process signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0007406,biological_process negative regulation of neuroblast proliferation;GO:0007420,biological_process brain development;GO:0007422,biological_process peripheral nervous system development;GO:0007507,biological_process heart development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008429,molecular_function phosphatidylethanolamine binding;GO:0008542,biological_process visual learning;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0010468,biological_process regulation of gene expression;GO:0014044,biological_process Schwann cell development;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0021510,biological_process spinal cord development;GO:0021764,biological_process amygdala development;GO:0021897,biological_process forebrain astrocyte development;GO:0021915,biological_process neural tube development;GO:0021987,biological_process cerebral cortex development;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030036,biological_process actin cytoskeleton organization;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0030325,biological_process adrenal gland development;GO:0030336,biological_process negative regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031210,molecular_function phosphatidylcholine binding;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0032228,biological_process regulation of synaptic transmission, GABAergic;GO:0034605,biological_process cellular response to heat;GO:0035021,biological_process negative regulation of Rac protein signal transduction;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0042992,biological_process negative regulation of transcription factor import into nucleus;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043408,biological_process regulation of MAPK cascade;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0043473,biological_process pigmentation;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043535,biological_process regulation of blood vessel endothelial cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045124,biological_process regulation of bone resorption;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045685,biological_process regulation of glial cell differentiation;GO:0045762,biological_process positive regulation of adenylate cyclase activity;GO:0045765,biological_process regulation of angiogenesis;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0046929,biological_process negative regulation of neurotransmitter secretion;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048485,biological_process sympathetic nervous system development;GO:0048593,biological_process camera-type eye morphogenesis;GO:0048712,biological_process negative regulation of astrocyte differentiation;GO:0048715,biological_process negative regulation of oligodendrocyte differentiation;GO:0048745,biological_process smooth muscle tissue development;GO:0048820,biological_process hair follicle maturation;GO:0048844,biological_process artery morphogenesis;GO:0048853,biological_process forebrain morphogenesis;GO:0050890,biological_process cognition;GO:0061534,biological_process gamma-aminobutyric acid secretion, neurotransmission;GO:0061535,biological_process glutamate secretion, neurotransmission;GO:0098597,biological_process observational learning;GO:0098793,cellular_component presynapse;GO:1900271,biological_process regulation of long-term synaptic potentiation;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	NF1; neurofibromin 1; K08052	neurofibromin 1 [Source:HGNC Symbol%3BAcc:HGNC:7765]
ENSG00000179859	4.21	3.42	4.39	3.46	3.73	3.98	0.130164878632128	1.46472156135433	0.607889759372242	0.87899667777958	17:7913323-7916276:-	AC104581.1	1;GO:0046872,molecular_function metal ion binding	NA	NA
ENSG00000125952	34.48	31.33	37.52	37.63	32.11	38.01	-0.0451099638131813	5.1075531569841	0.607945050850165	0.87899667777958	14:65006173-65102695:-	MAX	39;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0009267,biological_process cellular response to starvation;GO:0010243,biological_process response to organonitrogen compound;GO:0010629,biological_process negative regulation of gene expression;GO:0016605,cellular_component PML body;GO:0030425,cellular_component dendrite;GO:0032403,molecular_function protein complex binding;GO:0032868,biological_process response to insulin;GO:0032993,cellular_component protein-DNA complex;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048678,biological_process response to axon injury;GO:0051402,biological_process neuron apoptotic process;GO:0060041,biological_process retina development in camera-type eye;GO:0070888,molecular_function E-box binding;GO:0071339,cellular_component MLL1 complex;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0090575,cellular_component RNA polymerase II transcription factor complex	MAX; Max protein; K04453	MYC associated factor X [Source:HGNC Symbol%3BAcc:HGNC:6913]
ENSG00000164346	80.31	83.56	80.02	86.77	84.98	79.96	-0.0349179305450957	6.01342173128591	0.608018589549772	0.87899667777958	5:74766990-74780113:+	NSA2	9;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042254,biological_process ribosome biogenesis	NA	NSA2%2C ribosome biogenesis homolog [Source:HGNC Symbol%3BAcc:HGNC:30728]
ENSG00000163166	25.02	27.61	25.74	27.31	26.58	26.94	-0.0357512710271897	6.14695367945505	0.608129616306992	0.87899667777958	2:127436206-127526886:-	IWS1	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0006810,biological_process transport;GO:0008380,biological_process RNA splicing;GO:0010793,biological_process regulation of mRNA export from nucleus;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0050684,biological_process regulation of mRNA processing;GO:0051028,biological_process mRNA transport;GO:0090239,biological_process regulation of histone H4 acetylation;GO:2001253,biological_process regulation of histone H3-K36 trimethylation	NA	IWS1%2C SUPT6H interacting protein [Source:HGNC Symbol%3BAcc:HGNC:25467]
ENSG00000205426	0.89	1.01	1.17	1.28	0.65	1.53	-0.176336160987652	0.856516488412421	0.608138521612103	0.87899667777958	12:52285912-52291534:-	KRT81	8;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0031424,biological_process keratinization;GO:0045095,cellular_component keratin filament;GO:0070268,biological_process cornification	NA	keratin 81 [Source:HGNC Symbol%3BAcc:HGNC:6458]
ENSG00000142751	20.58	19.69	18.99	21.89	20.68	19.24	-0.0472389841423873	4.28973082499283	0.608253925977548	0.879061122733647	1:26876132-26890297:-	GPN2	10;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0044376,biological_process RNA polymerase II complex import to nucleus;GO:1990022,biological_process RNA polymerase III complex localization to nucleus	NA	GPN-loop GTPase 2 [Source:HGNC Symbol%3BAcc:HGNC:25513]
ENSG00000076513	11.22	10.93	10.80	10.66	11.88	11.75	-0.0456466014822907	4.36192787664598	0.608405595520704	0.879177957764669	12:109999185-110039763:+	ANKRD13A	5;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	ankyrin repeat domain 13A [Source:HGNC Symbol%3BAcc:HGNC:21268]
ENSG00000197769	1.92	4.98	3.67	3.06	6.02	3.03	-0.210905709857364	0.838527226423949	0.608607317739714	0.879180299160881	1:241995489-241999073:-	MAP1LC3C	20;GO:0000045,biological_process autophagosome assembly;GO:0000421,cellular_component autophagosome membrane;GO:0000422,biological_process mitophagy;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006914,biological_process autophagy;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0009267,biological_process cellular response to starvation;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0031090,cellular_component organelle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0097352,biological_process autophagosome maturation	MAP1LC; microtubule-associated protein 1 light chain; K10435	microtubule associated protein 1 light chain 3 gamma [Source:HGNC Symbol%3BAcc:HGNC:13353]
ENSG00000188739	38.45	33.74	37.09	37.73	37.24	38.18	-0.0341894290508613	5.68915938173113	0.608640672207965	0.879180299160881	1:235131182-235161457:-	RBM34	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus	NA	RNA binding motif protein 34 [Source:HGNC Symbol%3BAcc:HGNC:28965]
ENSG00000162923	40.83	39.43	42.55	40.51	38.11	42.30	0.0350983381946268	6.38248413602525	0.608671320783014	0.879180299160881	1:224385142-224437033:-	WDR26	4;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	WD repeat domain 26 [Source:HGNC Symbol%3BAcc:HGNC:21208]
ENSG00000186952	0.89	0.48	0.59	0.87	0.34	0.53	0.209671126897867	0.477896022541923	0.608807821139896	0.879180299160881	5:110289232-110738956:-	TMEM232	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 232 [Source:HGNC Symbol%3BAcc:HGNC:37270]
ENSG00000178531	12.06	14.37	14.96	12.17	12.95	13.43	0.106121055551217	1.77460018714185	0.608813193731432	0.879180299160881	19:7924484-7926166:-	CTXN1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031224,cellular_component intrinsic component of membrane	NA	cortexin 1 [Source:HGNC Symbol%3BAcc:HGNC:31108]
ENSG00000109756	3.32	3.25	3.32	3.16	3.61	3.56	-0.0512531083579935	4.14866887028189	0.60884673925147	0.879180299160881	4:159104177-159360169:+	RAPGEF2	73;GO:0000165,biological_process MAPK cascade;GO:0001568,biological_process blood vessel development;GO:0001764,biological_process neuron migration;GO:0004871,molecular_function signal transducer activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017034,molecular_function Rap guanyl-nucleotide exchange factor activity;GO:0019933,biological_process cAMP-mediated signaling;GO:0019992,molecular_function diacylglycerol binding;GO:0021591,biological_process ventricular system development;GO:0021884,biological_process forebrain neuron development;GO:0030033,biological_process microvillus assembly;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0030154,biological_process cell differentiation;GO:0030165,molecular_function PDZ domain binding;GO:0030552,molecular_function cAMP binding;GO:0031175,biological_process neuron projection development;GO:0031547,biological_process brain-derived neurotrophic factor receptor signaling pathway;GO:0031697,molecular_function beta-1 adrenergic receptor binding;GO:0032092,biological_process positive regulation of protein binding;GO:0032486,biological_process Rap protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0038180,biological_process nerve growth factor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043950,biological_process positive regulation of cAMP-mediated signaling;GO:0045202,cellular_component synapse;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0048022,biological_process negative regulation of melanin biosynthetic process;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050699,molecular_function WW domain binding;GO:0050774,biological_process negative regulation of dendrite morphogenesis;GO:0061028,biological_process establishment of endothelial barrier;GO:0070300,molecular_function phosphatidic acid binding;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071320,biological_process cellular response to cAMP;GO:0071321,biological_process cellular response to cGMP;GO:0071880,biological_process adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0072659,biological_process protein localization to plasma membrane;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:1901888,biological_process regulation of cell junction assembly;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000481,biological_process positive regulation of cAMP-dependent protein kinase activity;GO:2000670,biological_process positive regulation of dendritic cell apoptotic process;GO:2001214,biological_process positive regulation of vasculogenesis;GO:2001224,biological_process positive regulation of neuron migration	RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2; K08018	Rap guanine nucleotide exchange factor 2 [Source:HGNC Symbol%3BAcc:HGNC:16854]
ENSG00000141034	5.09	4.85	5.06	4.47	4.84	5.01	0.0800125347030232	2.61586415735933	0.608903007482969	0.879180299160881	17:18039291-18068404:+	GID4	3;GO:0016567,biological_process protein ubiquitination;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	GID complex subunit 4 homolog [Source:HGNC Symbol%3BAcc:HGNC:28453]
ENSG00000103199	4.31	5.22	5.19	4.90	5.11	5.58	-0.0805105633238883	3.01741872780972	0.609141494919465	0.879417080279255	16:4748238-4767624:-	ZNF500	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 500 [Source:HGNC Symbol%3BAcc:HGNC:23716]
ENSG00000100219	123.79	113.28	115.48	115.97	117.17	114.51	0.0329612756841667	7.18674843396857	0.609208690350545	0.879417080279255	22:28794554-28800597:-	XBP1	85;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0001525,biological_process angiogenesis;GO:0001889,biological_process liver development;GO:0001935,biological_process endothelial cell proliferation;GO:0002070,biological_process epithelial cell maturation;GO:0002639,biological_process positive regulation of immunoglobulin production;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0006986,biological_process response to unfolded protein;GO:0006990,biological_process positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010506,biological_process regulation of autophagy;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031017,biological_process exocrine pancreas development;GO:0031648,biological_process protein destabilization;GO:0031670,biological_process cellular response to nutrient;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035356,biological_process cellular triglyceride homeostasis;GO:0035470,biological_process positive regulation of vascular wound healing;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0042149,biological_process cellular response to glucose starvation;GO:0042593,biological_process glucose homeostasis;GO:0042632,biological_process cholesterol homeostasis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045348,biological_process positive regulation of MHC class II biosynthetic process;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048666,biological_process neuron development;GO:0051024,biological_process positive regulation of immunoglobulin secretion;GO:0055089,biological_process fatty acid homeostasis;GO:0055092,biological_process sterol homeostasis;GO:0060612,biological_process adipose tissue development;GO:0060691,biological_process epithelial cell maturation involved in salivary gland development;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071332,biological_process cellular response to fructose stimulus;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071353,biological_process cellular response to interleukin-4;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:1900100,biological_process positive regulation of plasma cell differentiation;GO:1900103,biological_process positive regulation of endoplasmic reticulum unfolded protein response;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903489,biological_process positive regulation of lactation;GO:1990418,biological_process response to insulin-like growth factor stimulus;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000347,biological_process positive regulation of hepatocyte proliferation;GO:2000778,biological_process positive regulation of interleukin-6 secretion	XBP1; X box-binding protein 1; K09027	X-box binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:12801]
ENSG00000115282	15.96	14.23	13.89	13.84	14.17	15.07	0.0470020141590381	4.51215137918647	0.609413942190092	0.879490225328389	2:74483072-74494886:+	TTC31	NA	NA	tetratricopeptide repeat domain 31 [Source:HGNC Symbol%3BAcc:HGNC:25759]
ENSG00000174370	4.71	5.27	4.91	7.40	4.36	4.85	-0.150541500200229	1.28247269696106	0.609456310416637	0.879490225328389	11:128899564-128906035:-	C11orf45	1;GO:0005576,cellular_component extracellular region	NA	chromosome 11 open reading frame 45 [Source:HGNC Symbol%3BAcc:HGNC:28584]
ENSG00000011454	19.06	20.36	19.15	17.96	19.23	20.38	0.034482650138901	6.39759897614818	0.609471918011343	0.879490225328389	9:122940832-123104866:+	RABGAP1	24;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005875,cellular_component microtubule associated complex;GO:0006886,biological_process intracellular protein transport;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0012505,cellular_component endomembrane system;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization;GO:0090630,biological_process activation of GTPase activity	NA	RAB GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17155]
ENSG00000146757	8.20	8.53	7.91	7.20	9.23	7.36	0.061401654262123	3.83990337021739	0.609606988971563	0.879582884354762	7:65373798-65401135:+	ZNF92	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 92 [Source:HGNC Symbol%3BAcc:HGNC:13168]
ENSG00000119487	40.71	42.56	40.95	40.28	41.69	40.42	0.0318941190748007	6.20587685035647	0.609686182773229	0.879594907806147	9:125437392-125707234:-	MAPKAP1	26;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0017016,molecular_function Ras GTPase binding;GO:0019901,molecular_function protein kinase binding;GO:0021762,biological_process substantia nigra development;GO:0030950,biological_process establishment or maintenance of actin cytoskeleton polarity;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031295,biological_process T cell costimulation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031932,cellular_component TORC2 complex;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038203,biological_process TORC2 signaling;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0070300,molecular_function phosphatidic acid binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	mitogen-activated protein kinase associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18752]
ENSG00000124444	12.46	12.55	14.58	12.33	14.42	11.03	0.0852900591741314	2.75030405135017	0.60992524575102	0.879728093537438	19:43596391-43601157:+	ZNF576	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 576 [Source:HGNC Symbol%3BAcc:HGNC:28357]
ENSG00000147536	5.56	5.68	5.91	4.45	6.20	8.15	-0.125010630825172	2.07119078741699	0.609953512281743	0.879728093537438	8:41529205-41545046:+	GINS4	14;GO:0000727,biological_process double-strand break repair via break-induced replication;GO:0000811,cellular_component GINS complex;GO:0001833,biological_process inner cell mass cell proliferation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006271,biological_process DNA strand elongation involved in DNA replication;GO:0031298,cellular_component replication fork protection complex;GO:0032508,biological_process DNA duplex unwinding;GO:0043138,molecular_function 3'-5' DNA helicase activity	NA	GINS complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:28226]
ENSG00000211450	166.14	157.97	158.26	160.38	156.24	158.89	0.0335353798865415	5.87360027367504	0.610163037242796	0.879728093537438	11:57741249-57743554:+	SELENOH	1;GO:0003723,molecular_function RNA binding	NA	selenoprotein H [Source:HGNC Symbol%3BAcc:HGNC:18251]
ENSG00000188993	0.40	0.40	0.50	0.43	0.34	0.37	0.204049710497749	0.297140275567351	0.610169792127479	0.879728093537438	4:51993701-52017620:-	LRRC66	7;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0046426,biological_process negative regulation of JAK-STAT cascade	NA	leucine rich repeat containing 66 [Source:HGNC Symbol%3BAcc:HGNC:34299]
ENSG00000147604	3268.91	3142.36	3110.44	3311.47	3148.07	3337.37	-0.029311580912776	11.2270834983309	0.610258738776145	0.879728093537438	8:73290266-73295789:-	RPL7	26;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000463,biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002181,biological_process cytoplasmic translation;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005844,cellular_component polysome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0070062,cellular_component extracellular exosome	RP-L7e, RPL7; large subunit ribosomal protein L7e; K02937	ribosomal protein L7 [Source:HGNC Symbol%3BAcc:HGNC:10363]
ENSG00000167011	2.37	1.27	2.80	2.78	1.68	2.86	-0.146813636187707	1.48262942553754	0.610268978569489	0.879728093537438	7:101170492-101180276:-	NAT16	5;GO:0006473,biological_process protein acetylation;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups	NA	N-acetyltransferase 16 (putative) [Source:HGNC Symbol%3BAcc:HGNC:22030]
ENSG00000140391	138.93	137.12	130.43	133.76	132.80	134.06	0.0322764296794319	6.67667330815313	0.610371796597778	0.879728093537438	15:77041403-77083984:-	TSPAN3	7;GO:0003674,molecular_function molecular_function;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	tetraspanin 3 [Source:HGNC Symbol%3BAcc:HGNC:17752]
ENSG00000140406	5.07	4.40	4.88	4.41	4.61	4.60	0.0960908773624874	2.38664851538457	0.61039414485664	0.879728093537438	15:81000943-81005788:+	TLNRD1	2;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding	NA	talin rod domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:13519]
ENSG00000101158	55.89	55.73	54.06	52.58	55.04	55.68	0.0322692746207987	6.62548479907139	0.610416343320547	0.879728093537438	20:58981207-58995133:+	NELFCD	2;GO:0005634,cellular_component nucleus;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	negative elongation factor complex member C/D [Source:HGNC Symbol%3BAcc:HGNC:15934]
ENSG00000120318	2.39	2.54	2.73	2.52	2.60	2.93	-0.0621765059560025	3.62133644618657	0.61055166020432	0.879820961007223	5:141653400-141682221:-	ARAP3	22;GO:0001726,cellular_component ruffle;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030027,cellular_component lamellipodium;GO:0030336,biological_process negative regulation of cell migration;GO:0035021,biological_process negative regulation of Rac protein signal transduction;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; K12490	ArfGAP with RhoGAP domain%2C ankyrin repeat and PH domain 3 [Source:HGNC Symbol%3BAcc:HGNC:24097]
ENSG00000117266	18.01	17.87	18.03	20.35	17.73	17.93	-0.042643107556514	4.88574169766972	0.610739803824871	0.879905040669321	1:205504594-205532793:+	CDK18	12;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	cyclin dependent kinase 18 [Source:HGNC Symbol%3BAcc:HGNC:8751]
ENSG00000160014	319.07	336.18	296.20	309.97	345.00	328.15	-0.0365615174221442	7.18273264409515	0.610751778813089	0.879905040669321	19:46601073-46610793:+	CALM3	20;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0014069,cellular_component postsynaptic density;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0043209,cellular_component myelin sheath;GO:0043388,biological_process positive regulation of DNA binding;GO:0046872,molecular_function metal ion binding;GO:0090150,biological_process establishment of protein localization to membrane;GO:0090151,biological_process establishment of protein localization to mitochondrial membrane;GO:1900242,biological_process regulation of synaptic vesicle endocytosis;GO:2000300,biological_process regulation of synaptic vesicle exocytosis	CALM; calmodulin; K02183	calmodulin 3 [Source:HGNC Symbol%3BAcc:HGNC:1449]
ENSG00000211445	1.89	1.92	2.46	2.00	2.70	2.27	-0.135268676108268	1.09783950406277	0.611010273695734	0.880024756047721	5:151020437-151028993:+	GPX3	16;GO:0004601,molecular_function peroxidase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006979,biological_process response to oxidative stress;GO:0006982,biological_process response to lipid hydroperoxide;GO:0008134,molecular_function transcription factor binding;GO:0008430,molecular_function selenium binding;GO:0016491,molecular_function oxidoreductase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9]; K00432	glutathione peroxidase 3 [Source:HGNC Symbol%3BAcc:HGNC:4555]
ENSG00000163701	0.72	0.35	0.78	0.76	0.14	0.68	0.257941148207376	0.503268606308585	0.611101950554525	0.880024756047721	3:9902611-9916402:+	IL17RE	11;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030368,molecular_function interleukin-17 receptor activity;GO:0097398,biological_process cellular response to interleukin-17	IL17RE; interleukin 17 receptor E; K05168	interleukin 17 receptor E [Source:HGNC Symbol%3BAcc:HGNC:18439]
ENSG00000107164	43.34	43.83	45.16	45.94	45.48	44.99	-0.0319023926872874	6.26809549599083	0.611136279794132	0.880024756047721	9:130578964-130638352:+	FUBP3	15;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	far upstream element binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:4005]
ENSG00000183889	4.90	5.07	6.09	5.78	5.26	6.02	-0.0728763811475932	2.99552418869257	0.611151554737311	0.880024756047721	16:16317443-16350590:+	AC138969.1	1;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex-interacting protein family member A5 isoform 2  [Source:RefSeq peptide%3BAcc:NP_001338129]
ENSG00000141519	2.29	1.49	1.76	1.98	1.59	1.70	0.0962675056275018	2.90664362847216	0.611282929225093	0.880024756047721	17:80036631-80100613:+	CCDC40	19;GO:0001947,biological_process heart looping;GO:0003341,biological_process cilium movement;GO:0003351,biological_process epithelial cilium movement;GO:0003356,biological_process regulation of cilium beat frequency;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0030317,biological_process sperm motility;GO:0030324,biological_process lung development;GO:0035082,biological_process axoneme assembly;GO:0035469,biological_process determination of pancreatic left/right asymmetry;GO:0036159,biological_process inner dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry;GO:0070286,biological_process axonemal dynein complex assembly;GO:0071907,biological_process determination of digestive tract left/right asymmetry;GO:0071910,biological_process determination of liver left/right asymmetry	NA	coiled-coil domain containing 40 [Source:HGNC Symbol%3BAcc:HGNC:26090]
ENSG00000164008	7.22	5.76	5.55	7.02	7.11	6.01	-0.0971480022437824	2.00500444349629	0.611338750532462	0.880024756047721	1:42767268-42775747:+	C1orf50	2;GO:0005515,molecular_function protein binding;GO:0042802,molecular_function identical protein binding	NA	chromosome 1 open reading frame 50 [Source:HGNC Symbol%3BAcc:HGNC:28795]
ENSG00000151474	14.29	14.05	14.43	15.27	13.82	15.09	-0.034769132016191	5.77916992556136	0.61138422229706	0.880024756047721	10:13643705-14462142:-	FRMD4A	5;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005923,cellular_component bicellular tight junction;GO:0030674,molecular_function protein binding, bridging;GO:0090162,biological_process establishment of epithelial cell polarity	NA	FERM domain containing 4A [Source:HGNC Symbol%3BAcc:HGNC:25491]
ENSG00000178878	4.74	4.98	4.86	5.03	5.27	5.29	-0.0882691052877281	2.16890992520442	0.611514619322899	0.880024756047721	12:12725916-12829975:+	APOLD1	15;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006869,biological_process lipid transport;GO:0007275,biological_process multicellular organism development;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0042118,biological_process endothelial cell activation;GO:0042157,biological_process lipoprotein metabolic process;GO:0045601,biological_process regulation of endothelial cell differentiation	NA	apolipoprotein L domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25268]
ENSG00000127948	52.99	54.55	51.93	52.36	54.26	50.54	0.0322811719343313	7.00787657233	0.611573531678394	0.880024756047721	7:75899199-75986855:+	POR	43;GO:0003420,biological_process regulation of growth plate cartilage chondrocyte proliferation;GO:0003958,molecular_function NADPH-hemoprotein reductase activity;GO:0004128,molecular_function cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006805,biological_process xenobiotic metabolic process;GO:0007584,biological_process response to nutrient;GO:0008941,molecular_function nitric oxide dioxygenase activity;GO:0009055,molecular_function electron carrier activity;GO:0009437,biological_process carnitine metabolic process;GO:0009812,biological_process flavonoid metabolic process;GO:0010181,molecular_function FMN binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016787,molecular_function hydrolase activity;GO:0018393,biological_process internal peptidyl-lysine acetylation;GO:0019395,biological_process fatty acid oxidation;GO:0019899,molecular_function enzyme binding;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0032770,biological_process positive regulation of monooxygenase activity;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043602,biological_process nitrate catabolic process;GO:0045542,biological_process positive regulation of cholesterol biosynthetic process;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0046210,biological_process nitric oxide catabolic process;GO:0047726,molecular_function iron-cytochrome-c reductase activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process;GO:0060192,biological_process negative regulation of lipase activity;GO:0070988,biological_process demethylation;GO:0071371,biological_process cellular response to gonadotropin stimulus;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0071375,biological_process cellular response to peptide hormone stimulus;GO:0090031,biological_process positive regulation of steroid hormone biosynthetic process;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:0090346,biological_process cellular organofluorine metabolic process	NA	cytochrome p450 oxidoreductase [Source:HGNC Symbol%3BAcc:HGNC:9208]
ENSG00000147586	31.23	33.94	26.32	31.50	33.36	30.51	-0.0536616726645115	4.71357036824545	0.611717741902284	0.880024756047721	8:79918716-80030289:-	MRPS28	9;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0008150,biological_process biological_process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S28 [Source:HGNC Symbol%3BAcc:HGNC:14513]
ENSG00000110435	25.29	26.08	25.23	25.53	26.14	27.44	-0.0369945153899328	5.42183106166994	0.611815837654798	0.880024756047721	11:34915828-35020591:+	PDHX	11;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006090,biological_process pyruvate metabolic process;GO:0008152,biological_process metabolic process;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0034604,molecular_function pyruvate dehydrogenase (NAD+) activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0045254,cellular_component pyruvate dehydrogenase complex;GO:0061732,biological_process mitochondrial acetyl-CoA biosynthetic process from pyruvate	PDHX; dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; K13997	pyruvate dehydrogenase complex component X [Source:HGNC Symbol%3BAcc:HGNC:21350]
ENSG00000008516	4.15	4.93	5.18	4.19	5.30	4.13	0.0755069138638301	3.08916734915156	0.611820834889338	0.880024756047721	16:3046680-3060726:+	MMP25	18;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006954,biological_process inflammatory response;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031012,cellular_component extracellular matrix;GO:0031225,cellular_component anchored component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0060022,biological_process hard palate development	MMP25; matrix metalloproteinase-25 (membrane-inserted) [EC:3.4.24.-]; K08003	matrix metallopeptidase 25 [Source:HGNC Symbol%3BAcc:HGNC:14246]
ENSG00000089006	95.28	91.97	94.81	98.39	91.39	88.07	0.0339807008685071	7.17057679458159	0.611875310951747	0.880024756047721	20:17941596-17968980:-	SNX5	33;GO:0001726,cellular_component ruffle;GO:0001891,cellular_component phagocytic cup;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0006907,biological_process pinocytosis;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0016241,biological_process regulation of macroautophagy;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030904,cellular_component retromer complex;GO:0030905,cellular_component retromer, tubulation complex;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031313,cellular_component extrinsic component of endosome membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0034452,molecular_function dynactin binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0070685,cellular_component macropinocytic cup;GO:0097422,cellular_component tubular endosome	NA	sorting nexin 5 [Source:HGNC Symbol%3BAcc:HGNC:14969]
ENSG00000110876	0.55	0.97	1.03	0.64	0.95	0.66	0.178765384188761	0.221485076201341	0.611940533427855	0.880024756047721	12:108622276-108633959:-	SELPLG	16;GO:0001618,molecular_function virus receptor activity;GO:0001931,cellular_component uropod;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0044853,cellular_component plasma membrane raft;GO:0046718,biological_process viral entry into host cell;GO:0050900,biological_process leukocyte migration;GO:0050901,biological_process leukocyte tethering or rolling;GO:0050902,biological_process leukocyte adhesive activation;GO:0071354,biological_process cellular response to interleukin-6	SELPLG, CD162; selectin P ligand; K06544	selectin P ligand [Source:HGNC Symbol%3BAcc:HGNC:10722]
ENSG00000118689	14.38	12.73	14.76	12.94	14.65	13.41	0.0483573144637765	4.81237633671594	0.611990569354379	0.880024756047721	6:108559834-108684774:+	FOXO3	58;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001047,molecular_function core promoter binding;GO:0001221,molecular_function transcription cofactor binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001542,biological_process ovulation from ovarian follicle;GO:0001544,biological_process initiation of primordial ovarian follicle growth;GO:0001547,biological_process antral ovarian follicle growth;GO:0001556,biological_process oocyte maturation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006417,biological_process regulation of translation;GO:0006915,biological_process apoptotic process;GO:0007568,biological_process aging;GO:0008013,molecular_function beta-catenin binding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0031490,molecular_function chromatin DNA binding;GO:0031667,biological_process response to nutrient levels;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034599,biological_process cellular response to oxidative stress;GO:0042493,biological_process response to drug;GO:0042593,biological_process glucose homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048854,biological_process brain morphogenesis;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071386,biological_process cellular response to corticosterone stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0071548,biological_process response to dexamethasone;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097150,biological_process neuronal stem cell population maintenance;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1901300,biological_process positive regulation of hydrogen peroxide-mediated programmed cell death;GO:1903428,biological_process positive regulation of reactive oxygen species biosynthetic process;GO:1904646,biological_process cellular response to beta-amyloid;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990785,biological_process response to water-immersion restraint stress;GO:2000177,biological_process regulation of neural precursor cell proliferation;GO:2000353,biological_process positive regulation of endothelial cell apoptotic process;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	FOXO3; forkhead box protein O3; K09408	forkhead box O3 [Source:HGNC Symbol%3BAcc:HGNC:3821]
ENSG00000187815	0.94	0.79	1.17	1.00	0.58	0.98	0.202449680982471	0.673983024176207	0.612003885070379	0.880024756047721	1:40477214-40496343:+	ZFP69	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP69 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:24708]
ENSG00000168646	3.16	4.24	2.99	3.35	4.01	3.63	-0.0848214016554108	3.23369849690428	0.612040096589058	0.880024756047721	17:65528562-65561647:-	AXIN2	39;GO:0001756,biological_process somitogenesis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001957,biological_process intramembranous ossification;GO:0003139,biological_process secondary heart field specification;GO:0003413,biological_process chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0008013,molecular_function beta-catenin binding;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010942,biological_process positive regulation of cell death;GO:0016055,biological_process Wnt signaling pathway;GO:0016579,biological_process protein deubiquitination;GO:0019899,molecular_function enzyme binding;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030282,biological_process bone mineralization;GO:0030877,cellular_component beta-catenin destruction complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032423,biological_process regulation of mismatch repair;GO:0034613,biological_process cellular protein localization;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0042476,biological_process odontogenesis;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043570,biological_process maintenance of DNA repeat elements;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0048255,biological_process mRNA stabilization;GO:0061181,biological_process regulation of chondrocyte development;GO:0070411,molecular_function I-SMAD binding;GO:0070602,biological_process regulation of centromeric sister chromatid cohesion;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1904837,biological_process beta-catenin-TCF complex assembly	AXIN2; axin 2; K04385	axin 2 [Source:HGNC Symbol%3BAcc:HGNC:904]
ENSG00000013523	7.69	6.74	6.50	5.85	7.38	6.98	0.0641361829567678	3.85504314725336	0.612121328983162	0.880039617404214	14:76786177-76826246:-	ANGEL1	7;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005801,cellular_component cis-Golgi network;GO:0005829,cellular_component cytosol;GO:0008190,molecular_function eukaryotic initiation factor 4E binding;GO:0019904,molecular_function protein domain specific binding;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	angel homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:19961]
ENSG00000107651	15.46	14.46	14.31	14.49	16.95	14.48	-0.0401639711886483	5.52887867486663	0.612509675075493	0.880495957928442	10:119892710-119944658:+	SEC23IP	19;GO:0000139,cellular_component Golgi membrane;GO:0003723,molecular_function RNA binding;GO:0004620,molecular_function phospholipase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0048208,biological_process COPII vesicle coating	NA	SEC23 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:17018]
ENSG00000121749	20.28	16.97	20.57	19.25	19.23	21.70	-0.0413375364365477	5.46791849662913	0.612660017391899	0.880610096790834	12:71839706-71927248:+	TBC1D15	13;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0043087,biological_process regulation of GTPase activity;GO:0070062,cellular_component extracellular exosome;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 15 [Source:HGNC Symbol%3BAcc:HGNC:25694]
ENSG00000175087	6.14	5.04	6.55	6.37	5.12	5.50	0.0874408006569713	2.6089293213456	0.612776141690937	0.880645302763482	1:26111164-26125543:+	PDIK1L	11;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	PDLIM1 interacting kinase 1 like [Source:HGNC Symbol%3BAcc:HGNC:18981]
ENSG00000125826	344.67	267.53	362.22	365.10	286.58	370.14	-0.056515585266131	9.24359874194041	0.612826401778052	0.880645302763482	20:407497-430966:+	RBCK1	21;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016032,biological_process viral process;GO:0016740,molecular_function transferase activity;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060546,biological_process negative regulation of necroptotic process;GO:0071797,cellular_component LUBAC complex;GO:0097039,biological_process protein linear polyubiquitination;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]; K10630	RANBP2-type and C3HC4-type zinc finger containing 1 [Source:HGNC Symbol%3BAcc:HGNC:15864]
ENSG00000089505	3.15	3.43	4.40	3.82	2.47	3.90	0.116941203273156	1.76835647672835	0.61331828706248	0.881093850631599	16:66566392-66579137:+	CMTM1	5;GO:0005125,molecular_function cytokine activity;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	CKLF like MARVEL transmembrane domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19172]
ENSG00000134480	19.61	18.78	21.73	22.91	20.46	19.52	-0.0486252055596617	4.40355034876324	0.61333589891053	0.881093850631599	5:87391493-87413019:-	CCNH	31;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005675,cellular_component holo TFIIH complex;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019907,cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045859,biological_process regulation of protein kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050821,biological_process protein stabilization;GO:0070985,cellular_component TFIIK complex;GO:1901409,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain	CCNH; cyclin H; K06634	cyclin H [Source:HGNC Symbol%3BAcc:HGNC:1594]
ENSG00000089220	181.16	195.56	174.88	171.77	199.14	169.97	0.0389292522265439	6.67648727367269	0.613381504523092	0.881093850631599	12:118135857-118145584:+	PEBP1	17;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008289,molecular_function lipid binding;GO:0008429,molecular_function phosphatidylethanolamine binding;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030414,molecular_function peptidase inhibitor activity;GO:0070062,cellular_component extracellular exosome	NA	phosphatidylethanolamine binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8630]
ENSG00000068400	25.67	23.94	27.31	25.55	25.94	28.09	-0.0352622106604908	6.04586159336052	0.613422464928565	0.881093850631599	X:48973719-49002264:-	GRIPAP1	13;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0072562,cellular_component blood microparticle;GO:0098837,cellular_component postsynaptic recycling endosome;GO:0098887,biological_process neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:1905244,biological_process regulation of modification of synaptic structure	NA	GRIP1 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18706]
ENSG00000166986	97.77	83.04	96.39	99.52	91.24	95.99	-0.0361982664370188	8.07377837796473	0.613660727330605	0.88133409792373	12:57475444-57517569:+	MARS	22;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004825,molecular_function methionine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006431,biological_process methionyl-tRNA aminoacylation;GO:0009267,biological_process cellular response to starvation;GO:0009303,biological_process rRNA transcription;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0032869,biological_process cellular response to insulin stimulus;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0070062,cellular_component extracellular exosome;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]; K01874	methionyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:6898]
ENSG00000130255	466.42	419.29	439.46	439.72	396.91	466.30	0.0367680897564792	7.71831378474186	0.613761669870884	0.881377094875901	19:5674946-5691876:+	RPL36	17;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L36e, RPL36; large subunit ribosomal protein L36e; K02920	ribosomal protein L36 [Source:HGNC Symbol%3BAcc:HGNC:13631]
ENSG00000177879	179.45	168.02	168.61	177.27	170.65	184.53	-0.032670977435162	6.74421675039786	0.613856081940881	0.881410705047097	5:115841480-115914081:+	AP3S1	20;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008089,biological_process anterograde axonal transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030133,cellular_component transport vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:1904115,cellular_component axon cytoplasm	AP3S; AP-3 complex subunit sigma; K12399	adaptor related protein complex 3 sigma 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:2013]
ENSG00000137692	55.98	51.99	50.43	59.67	49.00	55.74	-0.0414458237394361	5.63694365851036	0.614137020562281	0.881712102271524	11:103062075-103092215:-	DCUN1D5	12;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032182,molecular_function ubiquitin-like protein binding;GO:0045116,biological_process protein neddylation;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0097602,molecular_function cullin family protein binding	NA	defective in cullin neddylation 1 domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:28409]
ENSG00000143772	1.52	1.28	1.84	1.66	1.74	1.64	-0.0898831990675734	2.25048188856254	0.614467687671205	0.881994718532875	1:226631689-226739323:-	ITPKB	27;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0002262,biological_process myeloid cell homeostasis;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008440,molecular_function inositol-1,4,5-trisphosphate 3-kinase activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030217,biological_process T cell differentiation;GO:0032957,biological_process inositol trisphosphate metabolic process;GO:0033030,biological_process negative regulation of neutrophil apoptotic process;GO:0035726,biological_process common myeloid progenitor cell proliferation;GO:0043647,biological_process inositol phosphate metabolic process;GO:0045059,biological_process positive thymic T cell selection;GO:0045061,biological_process thymic T cell selection;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0046638,biological_process positive regulation of alpha-beta T cell differentiation;GO:0071277,biological_process cellular response to calcium ion	ITPK; 1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127]; K00911	inositol-trisphosphate 3-kinase B [Source:HGNC Symbol%3BAcc:HGNC:6179]
ENSG00000143324	16.44	17.85	16.21	15.63	17.00	16.84	0.0369836619312039	5.12591877496764	0.614496982899878	0.881994718532875	1:180632003-180890251:+	XPR1	17;GO:0000822,molecular_function inositol hexakisphosphate binding;GO:0001618,molecular_function virus receptor activity;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0009615,biological_process response to virus;GO:0015114,molecular_function phosphate ion transmembrane transporter activity;GO:0015562,molecular_function efflux transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030643,biological_process cellular phosphate ion homeostasis;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0046718,biological_process viral entry into host cell	NA	xenotropic and polytropic retrovirus receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:12827]
ENSG00000170456	3.50	3.52	3.56	3.81	3.58	3.66	-0.0512971032371613	3.96384956684914	0.614547032996925	0.881994718532875	12:31382222-31591097:-	DENND5B	10;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005262,molecular_function calcium channel activity;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050982,biological_process detection of mechanical stimulus;GO:0061024,biological_process membrane organization;GO:0070588,biological_process calcium ion transmembrane transport	NA	DENN domain containing 5B [Source:HGNC Symbol%3BAcc:HGNC:28338]
ENSG00000141027	26.72	26.02	27.53	28.12	26.62	27.95	-0.0305352598405858	7.71715540527327	0.614729002873444	0.88215388585758	17:16029156-16218185:-	NCOR1	31;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005876,cellular_component spindle microtubule;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007623,biological_process circadian rhythm;GO:0016020,cellular_component membrane;GO:0016569,biological_process covalent chromatin modification;GO:0016580,cellular_component Sin3 complex;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0017053,cellular_component transcriptional repressor complex;GO:0019216,biological_process regulation of lipid metabolic process;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0042826,molecular_function histone deacetylase binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0051225,biological_process spindle assembly;GO:0072362,biological_process regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter;GO:0072368,biological_process regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter;GO:1903799,biological_process negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:2000191,biological_process regulation of fatty acid transport	NCOR1, N-CoR; nuclear receptor co-repressor 1; K04650	nuclear receptor corepressor 1 [Source:HGNC Symbol%3BAcc:HGNC:7672]
ENSG00000125817	54.39	57.59	50.54	51.46	53.01	55.33	0.0342054997428904	6.59534016324791	0.614861844440353	0.88220696642423	20:3783850-3786690:-	CENPB	12;GO:0000775,cellular_component chromosome, centromeric region;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003696,molecular_function satellite DNA binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0016604,cellular_component nuclear body;GO:0019237,molecular_function centromeric DNA binding;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0043565,molecular_function sequence-specific DNA binding	NA	centromere protein B [Source:HGNC Symbol%3BAcc:HGNC:1852]
ENSG00000133142	115.21	105.26	114.44	112.87	102.18	114.64	0.0356469386730612	6.89786188453497	0.614908134496289	0.88220696642423	X:103576230-103587736:+	TCEAL4	7;GO:0003746,molecular_function translation elongation factor activity;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006414,biological_process translational elongation;GO:0050699,molecular_function WW domain binding	NA	transcription elongation factor A like 4 [Source:HGNC Symbol%3BAcc:HGNC:26121]
ENSG00000157445	3.64	3.94	3.12	3.93	3.47	2.83	0.0721534398262697	3.52843186790991	0.614995137183309	0.882229820623646	3:54122546-55074557:+	CACNA2D3	12;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0046872,molecular_function metal ion binding;GO:0061337,biological_process cardiac conduction;GO:0070588,biological_process calcium ion transmembrane transport	CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3; K04860	calcium voltage-gated channel auxiliary subunit alpha2delta 3 [Source:HGNC Symbol%3BAcc:HGNC:15460]
ENSG00000105185	91.65	91.58	93.90	98.94	94.20	93.06	-0.0340615548835259	5.57012162340575	0.61512400094162	0.882312713622409	19:32581067-32587452:+	PDCD5	18;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008201,molecular_function heparin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010698,molecular_function acetyltransferase activator activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0048487,molecular_function beta-tubulin binding;GO:0070062,cellular_component extracellular exosome;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:1903638,biological_process positive regulation of protein import into mitochondrial outer membrane;GO:1903645,biological_process negative regulation of chaperone-mediated protein folding	NA	programmed cell death 5 [Source:HGNC Symbol%3BAcc:HGNC:8764]
ENSG00000104369	2.71	2.84	3.12	2.76	2.41	3.05	0.08617520533893	2.52043294806666	0.615285633388562	0.882442584315681	8:74234699-74321328:-	JPH1	15;GO:0003674,molecular_function molecular_function;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0007517,biological_process muscle organ development;GO:0008307,molecular_function structural constituent of muscle;GO:0014701,cellular_component junctional sarcoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0030018,cellular_component Z disc;GO:0030314,cellular_component junctional membrane complex;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0060402,biological_process calcium ion transport into cytosol	NA	junctophilin 1 [Source:HGNC Symbol%3BAcc:HGNC:14201]
ENSG00000151576	13.60	12.32	14.40	13.45	15.54	13.28	-0.0484865576895197	4.18057077182919	0.615454282449734	0.882582487066606	3:114005832-114088422:+	QTRT2	13;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008479,molecular_function queuine tRNA-ribosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016763,molecular_function transferase activity, transferring pentosyl groups;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0101030,biological_process tRNA-guanine transglycosylation	NA	queuine tRNA-ribosyltransferase accessory subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:25771]
ENSG00000141741	64.96	64.24	60.23	62.86	71.73	62.36	-0.0443395918825607	4.77939701781623	0.61570635950382	0.882768909391216	17:39728495-39730787:-	MIEN1	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0031235,cellular_component intrinsic component of the cytoplasmic side of the plasma membrane;GO:0043066,biological_process negative regulation of apoptotic process;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0070062,cellular_component extracellular exosome	NA	migration and invasion enhancer 1 [Source:HGNC Symbol%3BAcc:HGNC:28230]
ENSG00000172340	78.17	82.38	81.22	79.89	84.49	84.77	-0.0324520696884514	6.94950067657493	0.615738628834861	0.882768909391216	3:67360459-67654614:-	SUCLG2	20;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004775,molecular_function succinate-CoA ligase (ADP-forming) activity;GO:0004776,molecular_function succinate-CoA ligase (GDP-forming) activity;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006104,biological_process succinyl-CoA metabolic process;GO:0006105,biological_process succinate metabolic process;GO:0008152,biological_process metabolic process;GO:0016874,molecular_function ligase activity;GO:0019003,molecular_function GDP binding;GO:0043234,cellular_component protein complex;GO:0045244,cellular_component succinate-CoA ligase complex (GDP-forming);GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	LSC2; succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]; K01900	succinate-CoA ligase GDP-forming beta subunit [Source:HGNC Symbol%3BAcc:HGNC:11450]
ENSG00000066654	19.08	21.08	18.40	17.96	19.73	19.32	0.0438898248156638	4.39749747121608	0.615875844248369	0.882768909391216	16:20702815-20742084:-	THUMPD1	5;GO:0000154,biological_process rRNA modification;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0006400,biological_process tRNA modification	NA	THUMP domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23807]
ENSG00000183032	2.52	2.88	2.63	3.67	2.71	2.43	-0.127626557256665	1.41200513036748	0.61592796479846	0.882768909391216	14:36678430-37172866:-	SLC25A21	12;GO:0005310,molecular_function dicarboxylic acid transmembrane transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006554,biological_process lysine catabolic process;GO:0006810,biological_process transport;GO:0006835,biological_process dicarboxylic acid transport;GO:0006839,biological_process mitochondrial transport;GO:0015139,molecular_function alpha-ketoglutarate transmembrane transporter activity;GO:0015742,biological_process alpha-ketoglutarate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 21 [Source:HGNC Symbol%3BAcc:HGNC:14411]
ENSG00000168894	65.01	72.65	65.96	70.46	70.49	69.15	-0.0374010174838084	5.7526609210558	0.615939863388167	0.882768909391216	2:85595724-85597613:+	RNF181	10;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 181 [Source:HGNC Symbol%3BAcc:HGNC:28037]
ENSG00000171135	53.13	58.14	54.56	55.37	50.15	56.61	0.039425270640977	4.91386873413797	0.616096120619473	0.882890919562401	3:9890553-9894349:+	JAGN1	18;GO:0002376,biological_process immune system process;GO:0002446,biological_process neutrophil mediated immunity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0007029,biological_process endoplasmic reticulum organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030223,biological_process neutrophil differentiation;GO:0038158,biological_process granulocyte colony-stimulating factor signaling pathway;GO:0050832,biological_process defense response to fungus;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:1904577,biological_process cellular response to tunicamycin;GO:1990266,biological_process neutrophil migration	NA	jagunal homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:26926]
ENSG00000162522	21.68	21.64	22.70	23.28	23.12	21.70	-0.0324375569132702	6.2650687282078	0.616232008895901	0.882966375912197	1:32741884-32774970:+	KIAA1522	1;GO:0030154,biological_process cell differentiation	NA	KIAA1522 [Source:HGNC Symbol%3BAcc:HGNC:29301]
ENSG00000129911	10.04	6.67	8.08	10.46	9.17	7.28	-0.0907025907957991	2.82967280672434	0.61631241103198	0.882966375912197	19:1852398-1863568:-	KLF16	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0046872,molecular_function metal ion binding	NA	Kruppel like factor 16 [Source:HGNC Symbol%3BAcc:HGNC:16857]
ENSG00000099795	120.29	122.31	116.22	120.60	121.05	111.21	0.0352645071805985	5.61180323319425	0.616362172502956	0.882966375912197	19:14566077-14572062:-	NDUFB7	11;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7; K03963	NADH:ubiquinone oxidoreductase subunit B7 [Source:HGNC Symbol%3BAcc:HGNC:7702]
ENSG00000100836	23.36	22.01	24.51	24.04	22.22	26.68	-0.0481119017681993	4.47437277975662	0.616546586064081	0.882995530983766	14:23321288-23326185:+	PABPN1	21;GO:0000165,biological_process MAPK cascade;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0006936,biological_process muscle contraction;GO:0016607,cellular_component nuclear speck;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031124,biological_process mRNA 3'-end processing;GO:0042405,cellular_component nuclear inclusion body;GO:0046778,biological_process modification by virus of host mRNA processing;GO:0070063,molecular_function RNA polymerase binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:1904247,biological_process positive regulation of polynucleotide adenylyltransferase activity	PABPN1, PABP2; polyadenylate-binding protein 2; K14396	poly(A) binding protein nuclear 1 [Source:HGNC Symbol%3BAcc:HGNC:8565]
ENSG00000165609	62.30	63.08	63.92	63.07	70.38	62.29	-0.03607668526472	5.69779998553345	0.61658765976901	0.882995530983766	10:12165324-12196144:-	NUDT5	24;GO:0000287,molecular_function magnesium ion binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006338,biological_process chromatin remodeling;GO:0009117,biological_process nucleotide metabolic process;GO:0009191,biological_process ribonucleoside diphosphate catabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0019144,molecular_function ADP-sugar diphosphatase activity;GO:0019303,biological_process D-ribose catabolic process;GO:0030515,molecular_function snoRNA binding;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0044715,molecular_function 8-oxo-dGDP phosphatase activity;GO:0046872,molecular_function metal ion binding;GO:0047631,molecular_function ADP-ribose diphosphatase activity;GO:0070062,cellular_component extracellular exosome;GO:1990966,biological_process ATP generation from poly-ADP-D-ribose	NUDT5; ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase [EC:3.6.1.13 3.6.1.58 2.7.7.96]; K13987	nudix hydrolase 5 [Source:HGNC Symbol%3BAcc:HGNC:8052]
ENSG00000169718	19.98	18.62	19.20	18.95	18.30	19.62	0.0371579570318662	5.29444894852498	0.616595928668918	0.882995530983766	17:82057505-82065887:-	DUS1L	7;GO:0002943,biological_process tRNA dihydrouridine synthesis;GO:0003824,molecular_function catalytic activity;GO:0008033,biological_process tRNA processing;GO:0016491,molecular_function oxidoreductase activity;GO:0017150,molecular_function tRNA dihydrouridine synthase activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	dihydrouridine synthase 1 like [Source:HGNC Symbol%3BAcc:HGNC:30086]
ENSG00000114302	27.01	31.45	26.57	28.36	29.18	30.49	-0.0449319953087757	5.28627545929703	0.616771858886718	0.883077711773889	3:48744596-48847846:-	PRKAR2A	29;GO:0000166,molecular_function nucleotide binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003091,biological_process renal water homeostasis;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005952,cellular_component cAMP-dependent protein kinase complex;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0007596,biological_process blood coagulation;GO:0008603,molecular_function cAMP-dependent protein kinase regulator activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030552,molecular_function cAMP binding;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034199,biological_process activation of protein kinase A activity;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0035556,biological_process intracellular signal transduction;GO:0044853,cellular_component plasma membrane raft;GO:0045859,biological_process regulation of protein kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0097546,cellular_component ciliary base;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity	PRKAR; cAMP-dependent protein kinase regulator; K04739	protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:9391]
ENSG00000074755	3.86	4.31	3.97	4.07	3.75	4.07	0.0366906109966174	5.17960935057879	0.616822442331994	0.883077711773889	17:4004444-4143020:-	ZZEF1	3;GO:0005509,molecular_function calcium ion binding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger ZZ-type and EF-hand domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29027]
ENSG00000136010	3.26	1.86	3.82	3.49	2.35	3.98	-0.111877458415757	3.16230313150914	0.616866739611004	0.883077711773889	12:105019783-105084577:-	ALDH1L2	15;GO:0003824,molecular_function catalytic activity;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006730,biological_process one-carbon metabolic process;GO:0008152,biological_process metabolic process;GO:0009058,biological_process biosynthetic process;GO:0009258,biological_process 10-formyltetrahydrofolate catabolic process;GO:0016155,molecular_function formyltetrahydrofolate dehydrogenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016742,molecular_function hydroxymethyl-, formyl- and related transferase activity;GO:0046655,biological_process folic acid metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	ALDH1L; formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]; K00289	aldehyde dehydrogenase 1 family member L2 [Source:HGNC Symbol%3BAcc:HGNC:26777]
ENSG00000154124	23.04	22.62	21.20	21.70	20.78	22.87	0.0425610976926432	4.5731359676138	0.617389564364893	0.883613575240432	5:14664663-14699711:+	OTULIN	22;GO:0001525,biological_process angiogenesis;GO:0002040,biological_process sprouting angiogenesis;GO:0002376,biological_process immune system process;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0045087,biological_process innate immune response;GO:0050728,biological_process negative regulation of inflammatory response;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0070431,biological_process nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071797,cellular_component LUBAC complex;GO:1990108,biological_process protein linear deubiquitination	NA	OTU deubiquitinase with linear linkage specificity [Source:HGNC Symbol%3BAcc:HGNC:25118]
ENSG00000135778	69.50	62.56	66.14	73.37	62.19	69.94	-0.0382032760209899	5.66399173104564	0.617408469310277	0.883613575240432	1:232950604-232983882:+	NTPCR	9;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005524,molecular_function ATP binding;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0070062,cellular_component extracellular exosome;GO:0098519,molecular_function nucleotide phosphatase activity, acting on free nucleotides	NTPCR; nucleoside-triphosphatase [EC:3.6.1.15]; K06928	nucleoside-triphosphatase%2C cancer-related [Source:HGNC Symbol%3BAcc:HGNC:28204]
ENSG00000071082	1369.31	1268.57	1283.53	1377.07	1269.28	1395.07	-0.0315802277146443	9.35210917955056	0.61745461626001	0.883613575240432	2:101001714-101024032:+	RPL31	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein L31 [Source:HGNC Symbol%3BAcc:HGNC:10334]
ENSG00000106013	1.99	1.34	1.21	2.11	0.62	1.24	0.216649104453477	0.451798297341665	0.617552361158698	0.883651580295438	7:118214668-118496171:+	ANKRD7	1;GO:0008584,biological_process male gonad development	NA	ankyrin repeat domain 7 [Source:HGNC Symbol%3BAcc:HGNC:18588]
ENSG00000143036	5.23	6.20	4.63	4.82	5.77	4.77	0.0677024622294662	3.44722000660634	0.617743340301693	0.883822969474979	1:94820341-94895246:+	SLC44A3	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0015220,molecular_function choline transmembrane transporter activity;GO:0015871,biological_process choline transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	SLC44A3; solute carrier family 44 (choline transporter-like protein), member 3; K15282	solute carrier family 44 member 3 [Source:HGNC Symbol%3BAcc:HGNC:28689]
ENSG00000116030	152.05	180.17	146.73	156.66	168.47	171.09	-0.0421463715461643	6.67493530109391	0.617943214834395	0.883921885838603	2:202206179-202238608:-	SUMO1	58;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000792,cellular_component heterochromatin;GO:0001222,molecular_function transcription corepressor binding;GO:0001650,cellular_component fibrillar center;GO:0001741,cellular_component XY body;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008022,molecular_function protein C-terminus binding;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0008134,molecular_function transcription factor binding;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0019899,molecular_function enzyme binding;GO:0030425,cellular_component dendrite;GO:0030578,biological_process PML body organization;GO:0030674,molecular_function protein binding, bridging;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031386,molecular_function protein tag;GO:0031510,cellular_component SUMO activating enzyme complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0031965,cellular_component nuclear membrane;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032880,biological_process regulation of protein localization;GO:0034605,biological_process cellular response to heat;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0043392,biological_process negative regulation of DNA binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0044388,molecular_function small protein activating enzyme binding;GO:0045202,cellular_component synapse;GO:0045759,biological_process negative regulation of action potential;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0050821,biological_process protein stabilization;GO:0060021,biological_process palate development;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0071276,biological_process cellular response to cadmium ion;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:0090204,biological_process protein localization to nuclear pore;GO:0097165,cellular_component nuclear stress granule;GO:1901896,biological_process positive regulation of calcium-transporting ATPase activity;GO:1902260,biological_process negative regulation of delayed rectifier potassium channel activity;GO:1903169,biological_process regulation of calcium ion transmembrane transport	SUMO, SMT3; small ubiquitin-related modifier; K12160	small ubiquitin-like modifier 1 [Source:HGNC Symbol%3BAcc:HGNC:12502]
ENSG00000174705	9.30	9.07	9.67	10.37	9.35	9.40	-0.0404277376551717	4.827688755684	0.617976812789923	0.883921885838603	5:172324999-172454523:-	SH3PXD2B	33;GO:0001501,biological_process skeletal system development;GO:0001654,biological_process eye development;GO:0002051,biological_process osteoblast fate commitment;GO:0002102,cellular_component podosome;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006801,biological_process superoxide metabolic process;GO:0007507,biological_process heart development;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0010628,biological_process positive regulation of gene expression;GO:0016176,molecular_function superoxide-generating NADPH oxidase activator activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042169,molecular_function SH2 domain binding;GO:0042995,cellular_component cell projection;GO:0043085,biological_process positive regulation of catalytic activity;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0048705,biological_process skeletal system morphogenesis;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0055114,biological_process oxidation-reduction process;GO:0060348,biological_process bone development;GO:0060378,biological_process regulation of brood size;GO:0060612,biological_process adipose tissue development;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0071800,biological_process podosome assembly;GO:0072657,biological_process protein localization to membrane;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:1904179,biological_process positive regulation of adipose tissue development;GO:1904888,biological_process cranial skeletal system development	NA	SH3 and PX domains 2B [Source:HGNC Symbol%3BAcc:HGNC:29242]
ENSG00000092094	20.98	20.03	20.88	20.73	22.39	21.23	-0.0415017846329137	4.46373992417928	0.618055855133935	0.883921885838603	14:20446410-20455105:-	OSGEP	13;GO:0000408,cellular_component EKC/KEOPS complex;GO:0002949,biological_process tRNA threonylcarbamoyladenosine modification;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0008033,biological_process tRNA processing;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0046872,molecular_function metal ion binding;GO:0061711,molecular_function N(6)-L-threonylcarbamoyladenine synthase	NA	O-sialoglycoprotein endopeptidase [Source:HGNC Symbol%3BAcc:HGNC:18028]
ENSG00000198909	6.09	5.46	5.18	6.75	5.60	5.33	-0.0645550491371588	3.5625831354937	0.618097314837595	0.883921885838603	17:63622414-63696303:+	MAP3K3	25;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001568,biological_process blood vessel development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:1900745,biological_process positive regulation of p38MAPK cascade	MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]; K04421	mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:6855]
ENSG00000185033	111.74	103.73	110.62	116.58	102.16	118.10	-0.03464621690489	8.21188791646025	0.618322225379214	0.884072692059157	15:90160603-90229679:+	SEMA4B	4;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045202,cellular_component synapse	SEMA4, CD100; semaphorin 4; K06521	semaphorin 4B [Source:HGNC Symbol%3BAcc:HGNC:10730]
ENSG00000198625	8.84	7.24	10.96	10.64	8.54	9.55	-0.0666733437373714	3.91604539821503	0.61834521166983	0.884072692059157	1:204516378-204558120:+	MDM4	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006461,biological_process protein complex assembly;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019899,molecular_function enzyme binding;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045023,biological_process G0 to G1 transition;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071456,biological_process cellular response to hypoxia;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	MDM4, MDMX; protein Mdm4; K10127	MDM4%2C p53 regulator [Source:HGNC Symbol%3BAcc:HGNC:6974]
ENSG00000154917	5.30	5.81	5.43	4.36	5.69	5.55	0.0886768420083337	2.09865665797284	0.618728919659107	0.884519414917482	3:133824238-133895836:-	RAB6B	17;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0042147,biological_process retrograde transport, endosome to Golgi	NA	RAB6B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:14902]
ENSG00000124659	20.07	17.58	19.78	18.68	18.56	18.97	0.0498623846258502	4.31195868249149	0.618877710548719	0.884531285276293	6:42744480-42746096:-	TBCC	11;GO:0003924,molecular_function GTPase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0007021,biological_process tubulin complex assembly;GO:0007023,biological_process post-chaperonin tubulin folding pathway;GO:0015631,molecular_function tubulin binding;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0051087,molecular_function chaperone binding	NA	tubulin folding cofactor C [Source:HGNC Symbol%3BAcc:HGNC:11580]
ENSG00000169429	12.80	9.30	12.10	9.80	6.11	15.10	0.157054574301339	1.77730342619621	0.618879740000371	0.884531285276293	4:73740505-73743716:+	CXCL8	38;GO:0001525,biological_process angiogenesis;GO:0002237,biological_process response to molecule of bacterial origin;GO:0005125,molecular_function cytokine activity;GO:0005153,molecular_function interleukin-8 receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0006928,biological_process movement of cell or subcellular component;GO:0006935,biological_process chemotaxis;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008009,molecular_function chemokine activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0019722,biological_process calcium-mediated signaling;GO:0030155,biological_process regulation of cell adhesion;GO:0030593,biological_process neutrophil chemotaxis;GO:0031623,biological_process receptor internalization;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035556,biological_process intracellular signal transduction;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0042119,biological_process neutrophil activation;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045091,biological_process regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048566,biological_process embryonic digestive tract development;GO:0050930,biological_process induction of positive chemotaxis;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:2000535,biological_process regulation of entry of bacterium into host cell	IL8, CXCL8; interleukin 8; K10030	C-X-C motif chemokine ligand 8 [Source:HGNC Symbol%3BAcc:HGNC:6025]
ENSG00000005007	22.83	23.59	22.69	22.84	22.48	22.84	0.0305022516086622	6.27909466309994	0.619094025711608	0.884735682841145	19:18831937-18868236:+	UPF1	37;GO:0000166,molecular_function nucleotide binding;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000294,biological_process nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006406,biological_process mRNA export from nucleus;GO:0006449,biological_process regulation of translational termination;GO:0008270,molecular_function zinc ion binding;GO:0009048,biological_process dosage compensation by inactivation of X chromosome;GO:0016787,molecular_function hydrolase activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0032204,biological_process regulation of telomere maintenance;GO:0035145,cellular_component exon-exon junction complex;GO:0042162,molecular_function telomeric DNA binding;GO:0044530,cellular_component supraspliceosomal complex;GO:0044770,biological_process cell cycle phase transition;GO:0046872,molecular_function metal ion binding;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0071044,biological_process histone mRNA catabolic process;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1	UPF1, RENT1; regulator of nonsense transcripts 1 [EC:3.6.4.-]; K14326	UPF1%2C RNA helicase and ATPase [Source:HGNC Symbol%3BAcc:HGNC:9962]
ENSG00000160094	7.74	8.72	8.65	8.56	8.67	6.92	0.0662588362278984	3.38760625951509	0.619327810456104	0.884967895843401	1:33256544-33300719:+	ZNF362	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 362 [Source:HGNC Symbol%3BAcc:HGNC:18079]
ENSG00000256671	1.40	0.79	1.10	1.49	1.45	0.87	-0.158286796131149	0.673890359749941	0.619426859717102	0.885007551757411	2:110446639-110473075:-	LIMS4	7;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0045216,biological_process cell-cell junction organization;GO:0046872,molecular_function metal ion binding	NA	LIM zinc finger domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:39941]
ENSG00000205923	5.72	8.00	5.66	5.76	6.76	8.35	-0.116742635173725	2.34947778448893	0.619540910388826	0.885068629376971	16:2530034-2531417:-	CEMP1	1;GO:0005737,cellular_component cytoplasm	NA	cementum protein 1 [Source:HGNC Symbol%3BAcc:HGNC:32553]
ENSG00000167635	98.36	89.89	100.24	96.41	90.91	96.97	0.0350728199250543	6.39036650253219	0.619810922217777	0.885142426495839	19:36214601-36238774:+	ZNF146	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008201,molecular_function heparin binding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 146 [Source:HGNC Symbol%3BAcc:HGNC:12931]
ENSG00000198938	14005.71	15303.53	14683.70	14462.13	15088.88	13848.81	0.0313425032035254	13.4803654562951	0.619838801535692	0.885142426495839	MT:9206-9990:+	MT-CO3	13;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0015002,molecular_function heme-copper terminal oxidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019646,biological_process aerobic electron transport chain;GO:0022904,biological_process respiratory electron transport chain;GO:0045277,cellular_component respiratory chain complex IV;GO:1902600,biological_process hydrogen ion transmembrane transport	COX3; cytochrome c oxidase subunit 3; K02262	mitochondrially encoded cytochrome c oxidase III [Source:HGNC Symbol%3BAcc:HGNC:7422]
ENSG00000140749	1.07	1.98	1.53	0.93	1.89	1.07	0.21951337783285	0.206102471633939	0.619918617727033	0.885142426495839	16:21639536-21652660:-	IGSF6	6;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	immunoglobulin superfamily member 6 [Source:HGNC Symbol%3BAcc:HGNC:5953]
ENSG00000197860	6.58	5.76	5.16	5.17	4.91	6.48	0.0912983776394352	2.41760962492911	0.619969694330903	0.885142426495839	5:65665927-65723035:-	SGTB	1;GO:0005515,molecular_function protein binding	NA	small glutamine rich tetratricopeptide repeat containing beta [Source:HGNC Symbol%3BAcc:HGNC:23567]
ENSG00000175711	4.94	4.87	5.34	5.56	5.70	4.92	-0.0775867593966658	2.63375716219552	0.620062958010751	0.885142426495839	17:82942154-83051810:-	B3GNTL1	2;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase like 1 [Source:HGNC Symbol%3BAcc:HGNC:21727]
ENSG00000161904	38.35	35.88	35.34	36.64	33.65	37.53	0.035499055028225	5.77923685952843	0.620133725866538	0.885142426495839	6:33771201-33789136:-	LEMD2	18;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0006998,biological_process nuclear envelope organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022008,biological_process neurogenesis;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0031490,molecular_function chromatin DNA binding;GO:0031965,cellular_component nuclear membrane;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060914,biological_process heart formation;GO:0070197,biological_process meiotic attachment of telomere to nuclear envelope;GO:0071168,biological_process protein localization to chromatin;GO:1902531,biological_process regulation of intracellular signal transduction	NA	LEM domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:21244]
ENSG00000121903	2.67	2.49	2.43	2.00	2.63	2.64	0.0765765423274974	2.99148372449014	0.620167966188672	0.885142426495839	1:33472644-33496507:+	ZSCAN20	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 20 [Source:HGNC Symbol%3BAcc:HGNC:13093]
ENSG00000147003	2.33	3.16	1.77	2.36	2.16	1.90	0.158527090206362	0.720801497016623	0.620210405763798	0.885142426495839	X:15627317-15665031:-	TMEM27	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0008237,molecular_function metallopeptidase activity;GO:0008241,molecular_function peptidyl-dipeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031526,cellular_component brush border membrane;GO:0035543,biological_process positive regulation of SNARE complex assembly;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0051957,biological_process positive regulation of amino acid transport;GO:0070062,cellular_component extracellular exosome	NA	transmembrane protein 27 [Source:HGNC Symbol%3BAcc:HGNC:29437]
ENSG00000135587	7.70	7.67	7.28	9.29	8.92	5.95	-0.0788551940164873	3.46196707736591	0.620293702625707	0.885142426495839	6:109440762-109443919:+	SMPD2	17;GO:0004767,molecular_function sphingomyelin phosphodiesterase activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006684,biological_process sphingomyelin metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0009612,biological_process response to mechanical stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0035556,biological_process intracellular signal transduction;GO:0046513,biological_process ceramide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:2000304,biological_process positive regulation of ceramide biosynthetic process	SMPD2; sphingomyelin phosphodiesterase 2 [EC:3.1.4.12]; K12351	sphingomyelin phosphodiesterase 2 [Source:HGNC Symbol%3BAcc:HGNC:11121]
ENSG00000134242	5.21	4.87	6.32	4.75	5.07	5.98	0.0683221409769776	3.84083415510764	0.620305644734335	0.885142426495839	1:113813810-113871759:-	PTPN22	58;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0002685,biological_process regulation of leukocyte migration;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006914,biological_process autophagy;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010507,biological_process negative regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019900,molecular_function kinase binding;GO:0030217,biological_process T cell differentiation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032496,biological_process response to lipopolysaccharide;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032817,biological_process regulation of natural killer cell proliferation;GO:0034141,biological_process positive regulation of toll-like receptor 3 signaling pathway;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0034157,biological_process positive regulation of toll-like receptor 7 signaling pathway;GO:0034165,biological_process positive regulation of toll-like receptor 9 signaling pathway;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035549,biological_process positive regulation of interferon-beta secretion;GO:0035644,biological_process phosphoanandamide dephosphorylation;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043508,biological_process negative regulation of JUN kinase activity;GO:0045088,biological_process regulation of innate immune response;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050855,biological_process regulation of B cell receptor signaling pathway;GO:0050856,biological_process regulation of T cell receptor signaling pathway;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0050868,biological_process negative regulation of T cell activation;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070433,biological_process negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071225,biological_process cellular response to muramyl dipeptide;GO:0071663,biological_process positive regulation of granzyme B production;GO:1900165,biological_process negative regulation of interleukin-6 secretion;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling;GO:1902523,biological_process positive regulation of protein K63-linked ubiquitination;GO:1902715,biological_process positive regulation of interferon-gamma secretion;GO:1902741,biological_process positive regulation of interferon-alpha secretion;GO:1903169,biological_process regulation of calcium ion transmembrane transport;GO:1903753,biological_process negative regulation of p38MAPK cascade;GO:1990782,molecular_function protein tyrosine kinase binding;GO:2000483,biological_process negative regulation of interleukin-8 secretion;GO:2000566,biological_process positive regulation of CD8-positive, alpha-beta T cell proliferation	NA	protein tyrosine phosphatase%2C non-receptor type 22 [Source:HGNC Symbol%3BAcc:HGNC:9652]
ENSG00000134014	15.32	13.52	15.40	16.55	13.85	15.75	-0.0446619192843603	4.68856269060694	0.620467791325146	0.885272033760808	8:28089672-28191156:+	ELP3	30;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000993,molecular_function RNA polymerase II core binding;GO:0001764,biological_process neuron migration;GO:0003824,molecular_function catalytic activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0007417,biological_process central nervous system development;GO:0008023,cellular_component transcription elongation factor complex;GO:0008080,molecular_function N-acetyltransferase activity;GO:0008607,molecular_function phosphorylase kinase regulator activity;GO:0010484,molecular_function H3 histone acetyltransferase activity;GO:0010485,molecular_function H4 histone acetyltransferase activity;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030335,biological_process positive regulation of cell migration;GO:0033588,cellular_component Elongator holoenzyme complex;GO:0043966,biological_process histone H3 acetylation;GO:0043967,biological_process histone H4 acetylation;GO:0045859,biological_process regulation of protein kinase activity;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding	NA	elongator acetyltransferase complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:20696]
ENSG00000125726	131.34	132.65	120.78	130.31	123.86	124.71	0.0330042620396625	6.58904449286703	0.620655255855268	0.88543773025301	19:6583182-6604103:-	CD70	17;GO:0002020,molecular_function protease binding;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0097191,biological_process extrinsic apoptotic signaling pathway	TNFSF7, CD70; tumor necrosis factor ligand superfamily member 7; K05470	CD70 molecule [Source:HGNC Symbol%3BAcc:HGNC:11937]
ENSG00000205560	16.55	16.06	16.40	15.80	14.50	17.72	0.0404368430899554	5.26708891871595	0.620778708944896	0.885509595781715	22:50568860-50578465:-	CPT1B	15;GO:0004095,molecular_function carnitine O-palmitoyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0006853,biological_process carnitine shuttle;GO:0015909,biological_process long-chain fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0043231,cellular_component intracellular membrane-bounded organelle	CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]; K08765	carnitine palmitoyltransferase 1B [Source:HGNC Symbol%3BAcc:HGNC:2329]
ENSG00000151287	15.66	15.30	15.67	15.94	14.26	14.97	0.058865408932861	3.40292212686331	0.620848305171052	0.885509595781715	13:102765989-102773811:-	TEX30	1;GO:0016787,molecular_function hydrolase activity	NA	testis expressed 30 [Source:HGNC Symbol%3BAcc:HGNC:25188]
ENSG00000093010	106.23	102.76	106.31	109.37	99.92	101.62	0.0325015191153677	6.99762869122865	0.621074954922051	0.885509679813834	22:19941606-19969975:+	COMT	43;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006584,biological_process catecholamine metabolic process;GO:0007565,biological_process female pregnancy;GO:0007612,biological_process learning;GO:0007614,biological_process short-term memory;GO:0008168,molecular_function methyltransferase activity;GO:0008171,molecular_function O-methyltransferase activity;GO:0008210,biological_process estrogen metabolic process;GO:0009712,biological_process catechol-containing compound metabolic process;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016036,biological_process cellular response to phosphate starvation;GO:0016206,molecular_function catechol O-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0032259,biological_process methylation;GO:0032496,biological_process response to lipopolysaccharide;GO:0032502,biological_process developmental process;GO:0035814,biological_process negative regulation of renal sodium excretion;GO:0042135,biological_process neurotransmitter catabolic process;GO:0042417,biological_process dopamine metabolic process;GO:0042420,biological_process dopamine catabolic process;GO:0042493,biological_process response to drug;GO:0043197,cellular_component dendritic spine;GO:0044297,cellular_component cell body;GO:0045211,cellular_component postsynaptic membrane;GO:0045963,biological_process negative regulation of dopamine metabolic process;GO:0046872,molecular_function metal ion binding;GO:0048265,biological_process response to pain;GO:0048609,biological_process multicellular organismal reproductive process;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050668,biological_process positive regulation of homocysteine metabolic process;GO:0051930,biological_process regulation of sensory perception of pain;GO:0070062,cellular_component extracellular exosome;GO:0102084,molecular_function L-dopa O-methyltransferase activity;GO:0102938,molecular_function orcinol O-methyltransferase activity	COMT; catechol O-methyltransferase [EC:2.1.1.6]; K00545	catechol-O-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:2228]
ENSG00000157578	2.18	2.20	1.84	2.02	1.97	2.73	-0.106708213999649	2.18852452949072	0.621175610787309	0.885509679813834	21:39405843-39445805:-	LCA5L	1;GO:0005515,molecular_function protein binding	NA	LCA5L%2C lebercilin like [Source:HGNC Symbol%3BAcc:HGNC:1255]
ENSG00000101191	11.40	12.22	10.76	10.57	11.88	11.34	0.0347998877425847	6.2927677160981	0.621207042010465	0.885509679813834	20:62877737-62937952:-	DIDO1	9;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0097190,biological_process apoptotic signaling pathway	NA	death inducer-obliterator 1 [Source:HGNC Symbol%3BAcc:HGNC:2680]
ENSG00000109576	3.41	3.31	3.77	3.22	4.29	3.76	-0.0858283159498428	2.31513514504849	0.621405735632465	0.885509679813834	4:170060221-170091699:-	AADAT	18;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006554,biological_process lysine catabolic process;GO:0006569,biological_process tryptophan catabolic process;GO:0008483,molecular_function transaminase activity;GO:0009058,biological_process biosynthetic process;GO:0016212,molecular_function kynurenine-oxoglutarate transaminase activity;GO:0016740,molecular_function transferase activity;GO:0019441,biological_process tryptophan catabolic process to kynurenine;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0033512,biological_process L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0042803,molecular_function protein homodimerization activity;GO:0047536,molecular_function 2-aminoadipate transaminase activity;GO:0070189,biological_process kynurenine metabolic process;GO:0097052,biological_process L-kynurenine metabolic process	AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]; K00825	aminoadipate aminotransferase [Source:HGNC Symbol%3BAcc:HGNC:17929]
ENSG00000170191	8.73	11.05	10.88	9.56	9.89	9.83	0.0687598363971935	2.91806282229215	0.62142991768254	0.885509679813834	20:25612934-25624175:-	NANP	9;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006045,biological_process N-acetylglucosamine biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0046380,biological_process N-acetylneuraminate biosynthetic process;GO:0050124,molecular_function N-acylneuraminate-9-phosphatase activity	NANP; N-acylneuraminate-9-phosphatase [EC:3.1.3.29]; K01097	N-acetylneuraminic acid phosphatase [Source:HGNC Symbol%3BAcc:HGNC:16140]
ENSG00000142556	4.91	5.52	5.98	5.69	4.95	5.15	0.0657778732247426	3.34741851042853	0.621518033575337	0.885509679813834	19:52012764-52030240:-	ZNF614	11;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 614 [Source:HGNC Symbol%3BAcc:HGNC:24722]
ENSG00000166173	27.25	17.75	27.03	27.85	18.55	30.60	-0.0816515727118275	5.38318849466615	0.621525322473514	0.885509679813834	15:70829129-70854159:-	LARP6	7;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006417,biological_process regulation of translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	La ribonucleoprotein domain family member 6 [Source:HGNC Symbol%3BAcc:HGNC:24012]
ENSG00000167930	10.27	12.33	9.96	9.92	11.80	9.79	0.0529520518970566	4.47042362130151	0.621536665931991	0.885509679813834	16:234545-268971:+	FAM234A	6;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	family with sequence similarity 234 member A [Source:HGNC Symbol%3BAcc:HGNC:14163]
ENSG00000168575	3.88	5.16	4.34	4.68	5.17	4.29	-0.0790562385359686	3.20183087236698	0.621540268216853	0.885509679813834	8:42416474-42541926:-	SLC20A2	22;GO:0001618,molecular_function virus receptor activity;GO:0004872,molecular_function receptor activity;GO:0005315,molecular_function inorganic phosphate transmembrane transporter activity;GO:0005436,molecular_function sodium:phosphate symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006817,biological_process phosphate ion transport;GO:0015293,molecular_function symporter activity;GO:0015319,molecular_function sodium:inorganic phosphate symporter activity;GO:0015321,molecular_function sodium-dependent phosphate transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0044341,biological_process sodium-dependent phosphate transport;GO:0046718,biological_process viral entry into host cell;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	NA	solute carrier family 20 member 2 [Source:HGNC Symbol%3BAcc:HGNC:10947]
ENSG00000100023	18.78	19.51	18.84	17.16	22.02	20.25	-0.0464103031090342	5.0684055942145	0.621606666714458	0.885509679813834	22:21666008-21700015:+	PPIL2	18;GO:0000209,biological_process protein polyubiquitination;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016853,molecular_function isomerase activity;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0050900,biological_process leukocyte migration;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0072659,biological_process protein localization to plasma membrane	PPIL2, CYC4, CHP60; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]; K10598	peptidylprolyl isomerase like 2 [Source:HGNC Symbol%3BAcc:HGNC:9261]
ENSG00000088038	21.35	21.35	21.48	22.38	21.79	21.96	-0.0315347085921127	5.8731904881995	0.621633074188169	0.885509679813834	19:54137727-54155681:+	CNOT3	18;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001829,biological_process trophectodermal cell differentiation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007275,biological_process multicellular organism development;GO:0017148,biological_process negative regulation of translation;GO:0030014,cellular_component CCR4-NOT complex;GO:0030015,cellular_component CCR4-NOT core complex;GO:0031047,biological_process gene silencing by RNA;GO:2000036,biological_process regulation of stem cell population maintenance	CNOT3, NOT3; CCR4-NOT transcription complex subunit 3; K12580	CCR4-NOT transcription complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:7879]
ENSG00000130706	49.34	52.20	50.63	55.68	51.37	49.99	-0.0348692063242149	5.9793971605018	0.621896551010362	0.885564765684079	20:62302092-62308862:+	ADRM1	19;GO:0000502,cellular_component proteasome complex;GO:0002020,molecular_function protease binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010950,biological_process positive regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0043130,molecular_function ubiquitin binding;GO:0043248,biological_process proteasome assembly;GO:0061133,molecular_function endopeptidase activator activity;GO:0070628,molecular_function proteasome binding	NA	adhesion regulating molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:15759]
ENSG00000128394	8.92	7.94	8.06	8.50	6.67	8.77	0.0717827674903945	3.37375818213459	0.621945548732544	0.885564765684079	22:39040603-39053910:+	APOBEC3F	24;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004126,molecular_function cytidine deaminase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0009972,biological_process cytidine deamination;GO:0010529,biological_process negative regulation of transposition;GO:0016553,biological_process base conversion or substitution editing;GO:0016787,molecular_function hydrolase activity;GO:0016814,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030895,cellular_component apolipoprotein B mRNA editing enzyme complex;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045869,biological_process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0046872,molecular_function metal ion binding;GO:0048525,biological_process negative regulation of viral process;GO:0051607,biological_process defense response to virus;GO:0070383,biological_process DNA cytosine deamination;GO:0080111,biological_process DNA demethylation	NA	apolipoprotein B mRNA editing enzyme catalytic subunit 3F [Source:HGNC Symbol%3BAcc:HGNC:17356]
ENSG00000214595	0.67	0.85	0.44	0.61	0.45	0.72	0.125968029459141	1.91800595843913	0.621966446547994	0.885564765684079	2:54723498-54972025:+	EML6	5;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton	NA	echinoderm microtubule associated protein like 6 [Source:HGNC Symbol%3BAcc:HGNC:35412]
ENSG00000105792	7.03	5.75	9.12	8.11	7.09	7.97	-0.0622066725850017	4.42563092263281	0.621981215487324	0.885564765684079	7:90245173-90311063:+	CFAP69	NA	NA	cilia and flagella associated protein 69 [Source:HGNC Symbol%3BAcc:HGNC:26107]
ENSG00000156261	143.78	144.60	137.15	141.15	148.09	148.71	-0.0300501678155682	7.89063435076921	0.622028453395592	0.885564765684079	21:29055804-29073797:-	CCT8	37;GO:0000166,molecular_function nucleotide binding;GO:0002199,cellular_component zona pellucida receptor complex;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0034774,cellular_component secretory granule lumen;GO:0035578,cellular_component azurophil granule lumen;GO:0042623,molecular_function ATPase activity, coupled;GO:0042995,cellular_component cell projection;GO:0043312,biological_process neutrophil degranulation;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044297,cellular_component cell body;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045296,molecular_function cadherin binding;GO:0046931,biological_process pore complex assembly;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:1901998,biological_process toxin transport;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	chaperonin containing TCP1 subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:1623]
ENSG00000143614	9.26	8.64	9.61	11.03	8.84	8.93	-0.0506534110562276	4.3895657020415	0.622260414643797	0.885793409056588	1:153789029-153923360:-	GATAD2B	16;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016607,cellular_component nuclear speck;GO:0031492,molecular_function nucleosomal DNA binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	GATA zinc finger domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:30778]
ENSG00000204315	6.61	7.21	6.12	6.79	7.32	6.98	-0.0778238710321727	2.86794740448836	0.62255365070841	0.885998061434118	6:32128706-32130291:-	FKBPL	4;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0009314,biological_process response to radiation;GO:0050821,biological_process protein stabilization	NA	FK506 binding protein like [Source:HGNC Symbol%3BAcc:HGNC:13949]
ENSG00000111981	5.89	6.92	6.13	6.85	4.66	6.24	0.0928083233904694	2.20591947804983	0.622691153566144	0.885998061434118	6:149964006-149973710:+	ULBP1	11;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030101,biological_process natural killer cell activation;GO:0031225,cellular_component anchored component of membrane;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0046658,cellular_component anchored component of plasma membrane;GO:0046703,molecular_function natural killer cell lectin-like receptor binding;GO:0050776,biological_process regulation of immune response	ULBP; UL16 binding protein; K07986	UL16 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:14893]
ENSG00000108021	14.50	14.20	15.02	14.31	15.10	15.68	-0.0319507948069032	6.75695652458445	0.622773365458248	0.885998061434118	10:5684837-5763740:+	FAM208B	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 208 member B [Source:HGNC Symbol%3BAcc:HGNC:23484]
ENSG00000099622	152.91	138.34	157.40	147.63	149.79	166.22	-0.0346354060749699	7.60489378441472	0.622931374040235	0.885998061434118	19:1259383-1274880:+	CIRBP	17;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0009409,biological_process response to cold;GO:0009411,biological_process response to UV;GO:0010494,cellular_component cytoplasmic stress granule;GO:0017148,biological_process negative regulation of translation;GO:0030371,molecular_function translation repressor activity;GO:0034063,biological_process stress granule assembly;GO:0045727,biological_process positive regulation of translation;GO:0048255,biological_process mRNA stabilization;GO:0070181,molecular_function small ribosomal subunit rRNA binding	NA	cold inducible RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:1982]
ENSG00000070061	19.29	20.21	17.37	18.30	18.28	19.33	0.0339346383249118	6.24878260677879	0.622945910007572	0.885998061434118	9:108867516-108934116:-	ELP1	22;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000993,molecular_function RNA polymerase II core binding;GO:0002098,biological_process tRNA wobble uridine modification;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006461,biological_process protein complex assembly;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0008023,cellular_component transcription elongation factor complex;GO:0008607,molecular_function phosphorylase kinase regulator activity;GO:0030335,biological_process positive regulation of cell migration;GO:0033588,cellular_component Elongator holoenzyme complex;GO:0045859,biological_process regulation of protein kinase activity	NA	elongator complex protein 1 [Source:HGNC Symbol%3BAcc:HGNC:5959]
ENSG00000162599	2.18	2.71	2.05	2.35	2.27	2.78	-0.0989498995651635	2.27922599010139	0.622957194257654	0.885998061434118	1:60865258-61462793:+	NFIA	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0019079,biological_process viral genome replication;GO:0030054,cellular_component cell junction;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060074,biological_process synapse maturation;GO:0072189,biological_process ureter development	NA	nuclear factor I A [Source:HGNC Symbol%3BAcc:HGNC:7784]
ENSG00000078487	5.95	5.40	6.46	6.00	6.07	6.64	-0.0536896016962638	3.59146713603018	0.622961120603372	0.885998061434118	7:100400825-100428992:-	ZCWPW1	2;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CW-type and PWWP domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23486]
ENSG00000150093	810.10	772.86	780.74	767.99	748.22	819.27	0.0292360948440442	10.9217063050628	0.623041322279939	0.885998061434118	10:32900318-33005792:-	ITGB1	99;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0001618,molecular_function virus receptor activity;GO:0001701,biological_process in utero embryonic development;GO:0001708,biological_process cell fate specification;GO:0001726,cellular_component ruffle;GO:0001968,molecular_function fibronectin binding;GO:0002020,molecular_function protease binding;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0003779,molecular_function actin binding;GO:0004872,molecular_function receptor activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006968,biological_process cellular defense response;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007161,biological_process calcium-independent cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008305,cellular_component integrin complex;GO:0008354,biological_process germ cell migration;GO:0008542,biological_process visual learning;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010710,biological_process regulation of collagen catabolic process;GO:0014704,cellular_component intercalated disc;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016477,biological_process cell migration;GO:0019960,molecular_function C-X3-C chemokine binding;GO:0021943,biological_process formation of radial glial scaffolds;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030183,biological_process B cell differentiation;GO:0030198,biological_process extracellular matrix organization;GO:0031175,biological_process neuron projection development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031589,biological_process cell-substrate adhesion;GO:0031594,cellular_component neuromuscular junction;GO:0031623,biological_process receptor internalization;GO:0032154,cellular_component cleavage furrow;GO:0032403,molecular_function protein complex binding;GO:0032587,cellular_component ruffle membrane;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0033631,biological_process cell-cell adhesion mediated by integrin;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0034665,cellular_component integrin alpha1-beta1 complex;GO:0034666,cellular_component integrin alpha2-beta1 complex;GO:0034667,cellular_component integrin alpha3-beta1 complex;GO:0034677,cellular_component integrin alpha7-beta1 complex;GO:0034678,cellular_component integrin alpha8-beta1 complex;GO:0034680,cellular_component integrin alpha10-beta1 complex;GO:0034681,cellular_component integrin alpha11-beta1 complex;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0035748,cellular_component myelin sheath abaxonal region;GO:0042383,cellular_component sarcolemma;GO:0042470,cellular_component melanosome;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0043235,cellular_component receptor complex;GO:0043236,molecular_function laminin binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0045214,biological_process sarcomere organization;GO:0045296,molecular_function cadherin binding;GO:0045596,biological_process negative regulation of cell differentiation;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048333,biological_process mesodermal cell differentiation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048675,biological_process axon extension;GO:0048738,biological_process cardiac muscle tissue development;GO:0048813,biological_process dendrite morphogenesis;GO:0050776,biological_process regulation of immune response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration;GO:0050901,biological_process leukocyte tethering or rolling;GO:0051726,biological_process regulation of cell cycle;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:0071404,biological_process cellular response to low-density lipoprotein particle stimulus;GO:0071438,cellular_component invadopodium membrane;GO:0071711,biological_process basement membrane organization;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0097060,cellular_component synaptic membrane;GO:0098639,molecular_function collagen binding involved in cell-matrix adhesion;GO:2000811,biological_process negative regulation of anoikis	ITGB1, CD29; integrin beta 1; K05719	integrin subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:6153]
ENSG00000180822	8.10	6.74	9.48	9.05	7.69	9.18	-0.0697083587793722	3.27925834561822	0.623102768892566	0.885998061434118	6:3231402-3303373:+	PSMG4	1;GO:0043248,biological_process proteasome assembly	NA	proteasome assembly chaperone 4 [Source:HGNC Symbol%3BAcc:HGNC:21108]
ENSG00000102858	21.05	23.31	22.13	20.96	22.36	21.96	0.0342255815088317	5.37669061239524	0.623129282572266	0.885998061434118	16:4616492-4690974:+	MGRN1	20;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006513,biological_process protein monoubiquitination;GO:0008333,biological_process endosome to lysosome transport;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0043951,biological_process negative regulation of cAMP-mediated signaling;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome	MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]; K10604	mahogunin ring finger 1 [Source:HGNC Symbol%3BAcc:HGNC:20254]
ENSG00000103248	10.76	10.55	11.37	11.25	11.18	11.70	-0.048967613368158	4.0102464071105	0.623189323643059	0.885998061434118	16:86530175-86555235:-	MTHFSD	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0008298,biological_process intracellular mRNA localization	NA	methenyltetrahydrofolate synthetase domain containing [Source:HGNC Symbol%3BAcc:HGNC:25778]
ENSG00000171940	30.27	30.01	30.60	31.77	30.24	31.61	-0.0310596817552454	6.66393321884645	0.623378773463861	0.886112373029744	20:53567064-53609907:-	ZNF217	17;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 217 [Source:HGNC Symbol%3BAcc:HGNC:13009]
ENSG00000136819	48.47	49.71	46.10	46.11	49.42	53.69	-0.0396929703662797	5.41221883432414	0.623550070293361	0.886112373029744	9:129827289-129835863:-	C9orf78	3;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol	NA	chromosome 9 open reading frame 78 [Source:HGNC Symbol%3BAcc:HGNC:24932]
ENSG00000170542	24.29	20.93	27.40	22.30	23.13	25.43	0.0530569884073291	4.76673247268574	0.623615724646238	0.886112373029744	6:2887265-2903280:-	SERPINB9	24;GO:0002020,molecular_function protease binding;GO:0002448,biological_process mast cell mediated immunity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0009617,biological_process response to bacterium;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010628,biological_process positive regulation of gene expression;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0030414,molecular_function peptidase inhibitor activity;GO:0033668,biological_process negative regulation by symbiont of host apoptotic process;GO:0042270,biological_process protection from natural killer cell mediated cytotoxicity;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070062,cellular_component extracellular exosome;GO:0071391,biological_process cellular response to estrogen stimulus	SERPINB; serpin B; K13963	serpin family B member 9 [Source:HGNC Symbol%3BAcc:HGNC:8955]
ENSG00000198721	62.81	58.62	56.56	63.72	60.46	59.51	-0.0330286464138312	6.46721108133812	0.623657744106998	0.886112373029744	6:4115688-4135597:-	ECI2	15;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0003824,molecular_function catalytic activity;GO:0004165,molecular_function dodecenoyl-CoA delta-isomerase activity;GO:0005102,molecular_function receptor binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0016863,molecular_function intramolecular oxidoreductase activity, transposing C=C bonds;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0043231,cellular_component intracellular membrane-bounded organelle	ECI2, PECI; Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]; K13239	enoyl-CoA delta isomerase 2 [Source:HGNC Symbol%3BAcc:HGNC:14601]
ENSG00000143924	34.72	31.44	34.15	33.18	36.21	34.19	-0.0326166299555824	6.66401220594483	0.623690662769176	0.886112373029744	2:42169349-42332548:+	EML4	9;GO:0000278,biological_process mitotic cell cycle;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007017,biological_process microtubule-based process;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane	EML4; echinoderm microtubule-associated protein-like 4; K15420	echinoderm microtubule associated protein like 4 [Source:HGNC Symbol%3BAcc:HGNC:1316]
ENSG00000185122	55.66	58.29	56.32	56.48	55.56	55.90	0.0305968055640965	6.62352814088635	0.623698042629572	0.886112373029744	8:144291590-144314722:+	HSF1	112;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000791,cellular_component euchromatin;GO:0000792,cellular_component heterochromatin;GO:0000922,cellular_component spindle pole;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001162,molecular_function RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0001892,biological_process embryonic placenta development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0006810,biological_process transport;GO:0006952,biological_process defense response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007143,biological_process female meiotic division;GO:0007283,biological_process spermatogenesis;GO:0007584,biological_process response to nutrient;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009299,biological_process mRNA transcription;GO:0009408,biological_process response to heat;GO:0010243,biological_process response to organonitrogen compound;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0014070,biological_process response to organic cyclic compound;GO:0014823,biological_process response to activity;GO:0016605,cellular_component PML body;GO:0019901,molecular_function protein kinase binding;GO:0031072,molecular_function heat shock protein binding;GO:0031490,molecular_function chromatin DNA binding;GO:0032355,biological_process response to estradiol;GO:0032496,biological_process response to lipopolysaccharide;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0033574,biological_process response to testosterone;GO:0034605,biological_process cellular response to heat;GO:0034620,biological_process cellular response to unfolded protein;GO:0035690,biological_process cellular response to drug;GO:0035865,biological_process cellular response to potassium ion;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0042802,molecular_function identical protein binding;GO:0043200,biological_process response to amino acid;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043497,biological_process regulation of protein heterodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043621,molecular_function protein self-association;GO:0043623,biological_process cellular protein complex assembly;GO:0045120,cellular_component pronucleus;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051028,biological_process mRNA transport;GO:0051260,biological_process protein homooligomerization;GO:0051879,molecular_function Hsp90 protein binding;GO:0060136,biological_process embryonic process involved in female pregnancy;GO:0061408,biological_process positive regulation of transcription from RNA polymerase II promoter in response to heat stress;GO:0061770,molecular_function translation elongation factor binding;GO:0070207,biological_process protein homotrimerization;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071276,biological_process cellular response to cadmium ion;GO:0071280,biological_process cellular response to copper ion;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071478,biological_process cellular response to radiation;GO:0071480,biological_process cellular response to gamma radiation;GO:0072738,biological_process cellular response to diamide;GO:0090084,biological_process negative regulation of inclusion body assembly;GO:0090261,biological_process positive regulation of inclusion body assembly;GO:0097165,cellular_component nuclear stress granule;GO:0097431,cellular_component mitotic spindle pole;GO:0097677,molecular_function STAT family protein binding;GO:0098847,molecular_function sequence-specific single stranded DNA binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1900365,biological_process positive regulation of mRNA polyadenylation;GO:1901215,biological_process negative regulation of neuron death;GO:1901652,biological_process response to peptide;GO:1902512,biological_process positive regulation of apoptotic DNA fragmentation;GO:1903936,biological_process cellular response to sodium arsenite;GO:1904385,biological_process cellular response to angiotensin;GO:1904528,biological_process positive regulation of microtubule binding;GO:1904843,biological_process cellular response to nitroglycerin;GO:1904845,biological_process cellular response to L-glutamine;GO:1990841,molecular_function promoter-specific chromatin binding;GO:1990904,cellular_component ribonucleoprotein complex;GO:1990910,biological_process response to hypobaric hypoxia;GO:1990911,biological_process response to psychosocial stress;GO:2001033,biological_process negative regulation of double-strand break repair via nonhomologous end joining	HSF1; heat shock transcription factor 1; K09414	heat shock transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:5224]
ENSG00000168952	4.76	4.45	3.34	3.03	2.97	5.43	0.136531772802631	1.77350917265424	0.623975580317898	0.886244329683827	14:24809655-25050297:-	STXBP6	15;GO:0000145,cellular_component exocyst;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017049,molecular_function GTP-Rho binding;GO:0035542,biological_process regulation of SNARE complex assembly;GO:0045920,biological_process negative regulation of exocytosis;GO:0051601,biological_process exocyst localization;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	NA	syntaxin binding protein 6 [Source:HGNC Symbol%3BAcc:HGNC:19666]
ENSG00000122140	43.04	42.33	45.69	46.63	42.79	46.11	-0.0353551472272028	5.44099689606297	0.623994632570266	0.886244329683827	9:135499983-135504673:+	MRPS2	12;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015935,cellular_component small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2; K02967	mitochondrial ribosomal protein S2 [Source:HGNC Symbol%3BAcc:HGNC:14495]
ENSG00000121858	425.43	369.91	437.59	433.16	386.68	457.53	-0.0386981792094966	8.46419190162695	0.624032470815189	0.886244329683827	3:172505507-172523507:-	TNFSF10	30;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0008270,molecular_function zinc ion binding;GO:0008584,biological_process male gonad development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032813,molecular_function tumor necrosis factor receptor superfamily binding;GO:0032868,biological_process response to insulin;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10; K04721	TNF superfamily member 10 [Source:HGNC Symbol%3BAcc:HGNC:11925]
ENSG00000204272	155.58	160.03	178.45	168.82	166.35	148.93	0.0430927678381572	5.11811495866322	0.624123394436252	0.886244329683827	X:56729240-56818380:+	NBDY	6;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0010607,biological_process negative regulation of cytoplasmic mRNA processing body assembly	NA	negative regulator of P-body association [Source:HGNC Symbol%3BAcc:HGNC:50713]
ENSG00000019485	2.12	1.90	2.02	2.46	1.97	1.96	-0.0637394572390146	3.30740829587038	0.624163186655112	0.886244329683827	11:45095805-45235110:+	PRDM11	7;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	PR/SET domain 11 [Source:HGNC Symbol%3BAcc:HGNC:13996]
ENSG00000177034	4.17	3.50	6.21	5.33	3.70	6.22	-0.115302053676029	2.316525078966	0.624219300284033	0.886244329683827	5:79976730-79991262:-	MTX3	6;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane	NA	metaxin 3 [Source:HGNC Symbol%3BAcc:HGNC:24812]
ENSG00000169299	19.40	21.09	16.84	20.27	19.84	19.32	-0.0449112933025064	5.27221178970411	0.624429146515715	0.886440873250179	4:37826632-37862937:+	PGM2	22;GO:0000287,molecular_function magnesium ion binding;GO:0004614,molecular_function phosphoglucomutase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0005980,biological_process glycogen catabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0008973,molecular_function phosphopentomutase activity;GO:0016853,molecular_function isomerase activity;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0019388,biological_process galactose catabolic process;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046386,biological_process deoxyribose phosphate catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071704,biological_process organic substance metabolic process;GO:1904813,cellular_component ficolin-1-rich granule lumen	PGM2; phosphoglucomutase / phosphopentomutase [EC:5.4.2.2 5.4.2.7]; K15779	phosphoglucomutase 2 [Source:HGNC Symbol%3BAcc:HGNC:8906]
ENSG00000117477	0.90	0.79	1.46	1.10	1.60	0.90	-0.152825158647854	0.944786091800849	0.624686337417201	0.886663553393203	1:169394869-169460669:-	CCDC181	7;GO:0002177,cellular_component manchette;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0036126,cellular_component sperm flagellum;GO:0042995,cellular_component cell projection	NA	coiled-coil domain containing 181 [Source:HGNC Symbol%3BAcc:HGNC:28051]
ENSG00000127527	26.51	26.82	29.19	27.84	28.50	28.78	-0.0322696792792235	6.30873599217249	0.624767626538774	0.886663553393203	19:16355238-16472085:-	EPS15L1	13;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006897,biological_process endocytosis;GO:0016020,cellular_component membrane;GO:0030132,cellular_component clathrin coat of coated pit;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding;GO:0061024,biological_process membrane organization	NA	epidermal growth factor receptor pathway substrate 15 like 1 [Source:HGNC Symbol%3BAcc:HGNC:24634]
ENSG00000166046	8.56	8.28	10.08	8.58	8.00	9.55	0.0584938353244533	3.88546458873124	0.624800298197885	0.886663553393203	12:106301928-106347015:+	TCP11L2	NA	NA	t-complex 11 like 2 [Source:HGNC Symbol%3BAcc:HGNC:28627]
ENSG00000109079	29.35	27.97	31.16	30.60	29.73	31.43	-0.0375113530213816	4.94435593110556	0.62490026406673	0.886692034396716	17:28335601-28347009:+	TNFAIP1	20;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0006260,biological_process DNA replication;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0009790,biological_process embryo development;GO:0016477,biological_process cell migration;GO:0016567,biological_process protein ubiquitination;GO:0017049,molecular_function GTP-Rho binding;GO:0019904,molecular_function protein domain specific binding;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0043149,biological_process stress fiber assembly;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045740,biological_process positive regulation of DNA replication;GO:0051260,biological_process protein homooligomerization	NA	TNF alpha induced protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11894]
ENSG00000101052	48.65	41.26	46.37	46.32	43.39	44.47	0.0384763951942507	5.89126867081796	0.624963232815344	0.886692034396716	20:43590930-43647296:+	IFT52	24;GO:0001841,biological_process neural tube formation;GO:0001947,biological_process heart looping;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0007368,biological_process determination of left/right symmetry;GO:0008022,molecular_function protein C-terminus binding;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0031514,cellular_component motile cilium;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035720,biological_process intraciliary anterograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0044292,cellular_component dendrite terminus;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060271,biological_process cilium morphogenesis;GO:0070613,biological_process regulation of protein processing;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:1905515,biological_process non-motile cilium assembly	NA	intraflagellar transport 52 [Source:HGNC Symbol%3BAcc:HGNC:15901]
ENSG00000050820	25.45	26.43	26.15	25.38	26.57	25.01	0.0311459523271683	6.27797863427799	0.625096765659572	0.886777307744299	16:75228186-75268053:-	BCAR1	35;GO:0001558,biological_process regulation of cell growth;GO:0001726,cellular_component ruffle;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008283,biological_process cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0015629,cellular_component actin cytoskeleton;GO:0016477,biological_process cell migration;GO:0017124,molecular_function SH3 domain binding;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0042981,biological_process regulation of apoptotic process;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0048012,biological_process hepatocyte growth factor receptor signaling pathway;GO:0050851,biological_process antigen receptor-mediated signaling pathway;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051301,biological_process cell division;GO:0060326,biological_process cell chemotaxis	BCAR1, CAS; breast cancer anti-estrogen resistance 1; K05726	BCAR1%2C Cas family scaffolding protein [Source:HGNC Symbol%3BAcc:HGNC:971]
ENSG00000258890	22.51	20.22	21.97	21.27	20.71	21.84	0.0345775763905131	5.92584547699423	0.625166214458258	0.886777307744299	17:64506587-64542461:+	CEP95	8;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	centrosomal protein 95 [Source:HGNC Symbol%3BAcc:HGNC:25141]
ENSG00000137714	28.92	34.45	28.13	34.99	29.54	30.96	-0.0588234214717807	4.11367191877897	0.625295312047925	0.886832325846952	11:110429882-110464881:+	FDX1	18;GO:0005506,molecular_function iron ion binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0016125,biological_process sterol metabolic process;GO:0042446,biological_process hormone biosynthetic process;GO:0044281,biological_process small molecule metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0071320,biological_process cellular response to cAMP;GO:1904322,biological_process cellular response to forskolin	NA	ferredoxin 1 [Source:HGNC Symbol%3BAcc:HGNC:3638]
ENSG00000136560	39.38	35.19	38.49	37.13	36.31	38.07	0.034679062070165	6.02900653792524	0.62534788915962	0.886832325846952	2:161136907-161236221:+	TANK	20;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0016032,biological_process viral process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0035800,molecular_function deubiquitinase activator activity;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071479,biological_process cellular response to ionizing radiation;GO:1903003,biological_process positive regulation of protein deubiquitination;GO:2000158,biological_process positive regulation of ubiquitin-specific protease activity	TANK; TRAF family member-associated NF-kappa-B activator; K12650	TRAF family member associated NFKB activator [Source:HGNC Symbol%3BAcc:HGNC:11562]
ENSG00000164944	30.71	32.43	31.54	30.48	31.17	31.83	0.029315657794566	7.42885123636085	0.625690928591091	0.887183025290849	8:94487692-94553529:-	VIRMA	10;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0036396,cellular_component MIS complex;GO:0080009,biological_process mRNA methylation	NA	vir like m6A methyltransferase associated [Source:HGNC Symbol%3BAcc:HGNC:24500]
ENSG00000071859	67.85	73.86	78.81	70.01	71.82	75.09	0.0347291406590726	6.21589127199889	0.625738128286585	0.887183025290849	X:154444125-154450654:+	FAM50A	3;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0007283,biological_process spermatogenesis	NA	family with sequence similarity 50 member A [Source:HGNC Symbol%3BAcc:HGNC:18786]
ENSG00000127463	61.09	62.10	58.47	62.02	57.80	59.45	0.0303502738343365	7.49801142420673	0.62588909016686	0.887265829210439	1:19215663-19251552:-	EMC1	5;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:28957]
ENSG00000136840	18.01	16.56	16.73	18.10	19.09	16.53	-0.0496209357387984	4.00285174420501	0.625939488149183	0.887265829210439	9:127907885-127917038:-	ST6GALNAC4	15;GO:0000139,cellular_component Golgi membrane;GO:0001665,molecular_function alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006664,biological_process glycolipid metabolic process;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0047290,molecular_function (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity;GO:0097503,biological_process sialylation	SIAT7D, ST6GalNAc IV; N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D) [EC:2.4.99.7]; K03374	ST6 N-acetylgalactosaminide alpha-2%2C6-sialyltransferase 4 [Source:HGNC Symbol%3BAcc:HGNC:17846]
ENSG00000143933	456.00	475.36	433.11	440.48	471.65	433.47	0.0314466274926435	8.37836610185229	0.626293648794676	0.88755208831326	2:47160081-47176601:-	CALM2	14;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0043388,biological_process positive regulation of DNA binding;GO:0046872,molecular_function metal ion binding;GO:0060315,biological_process negative regulation of ryanodine-sensitive calcium-release channel activity	CALM; calmodulin; K02183	calmodulin 2 [Source:HGNC Symbol%3BAcc:HGNC:1445]
ENSG00000137992	19.06	16.42	15.15	14.90	17.22	17.21	0.0514595476468168	4.62221029387044	0.626326558662437	0.88755208831326	1:100186918-100249834:-	DBT	11;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005947,cellular_component mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043754,molecular_function dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	DBT, bkdB; 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]; K09699	dihydrolipoamide branched chain transacylase E2 [Source:HGNC Symbol%3BAcc:HGNC:2698]
ENSG00000173638	6.59	6.09	5.80	5.80	6.76	5.33	0.0614106078795054	3.87791445838546	0.626355940838166	0.88755208831326	21:45493571-45544411:-	SLC19A1	15;GO:0005542,molecular_function folic acid binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008517,molecular_function folic acid transporter activity;GO:0008518,molecular_function reduced folate carrier activity;GO:0015350,molecular_function methotrexate transporter activity;GO:0015884,biological_process folic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0046655,biological_process folic acid metabolic process;GO:0051958,biological_process methotrexate transport;GO:0098838,biological_process reduced folate transmembrane transport	SLC19A1, RFC1; solute carrier family 19 (folate transporter), member 1; K14609	solute carrier family 19 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10937]
ENSG00000103888	0.67	0.68	0.94	0.55	0.72	0.84	0.128030252322588	1.66241035456452	0.626628170032883	0.887836488370982	15:80779342-80951776:+	CEMIP	25;GO:0004415,molecular_function hyalurononglucosaminidase activity;GO:0005515,molecular_function protein binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0007605,biological_process sensory perception of sound;GO:0008152,biological_process metabolic process;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030213,biological_process hyaluronan biosynthetic process;GO:0030214,biological_process hyaluronan catabolic process;GO:0030335,biological_process positive regulation of cell migration;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0032050,molecular_function clathrin heavy chain binding;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0046923,molecular_function ER retention sequence binding;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1900020,biological_process positive regulation of protein kinase C activity	NA	cell migration inducing hyaluronan binding protein [Source:HGNC Symbol%3BAcc:HGNC:29213]
ENSG00000095015	3.64	4.19	3.62	3.38	4.65	3.98	-0.0625242691130176	4.1588836250651	0.626921044951544	0.88815007201364	5:56815573-56896152:+	MAP3K1	25;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0071260,biological_process cellular response to mechanical stimulus	MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]; K04416	mitogen-activated protein kinase kinase kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:6848]
ENSG00000171044	0.66	0.94	0.93	0.63	1.03	1.19	-0.174689446563896	1.04599429669057	0.626992754235171	0.888150297651624	8:10896044-11201366:-	XKR6	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	XK related 6 [Source:HGNC Symbol%3BAcc:HGNC:27806]
ENSG00000163689	12.93	10.91	11.65	12.13	11.20	11.50	0.044353307751848	4.96925059720593	0.627227613541359	0.888381602794259	3:58717364-59050084:-	C3orf67	NA	NA	chromosome 3 open reading frame 67 [Source:HGNC Symbol%3BAcc:HGNC:24763]
ENSG00000171320	2.54	3.44	2.45	2.73	3.18	3.07	-0.101429366242339	2.4439022608324	0.627481945606092	0.888467670266323	8:27771948-27812640:+	ESCO2	22;GO:0000785,cellular_component chromatin;GO:0001741,cellular_component XY body;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0004468,molecular_function lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0006275,biological_process regulation of DNA replication;GO:0006302,biological_process double-strand break repair;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0008080,molecular_function N-acetyltransferase activity;GO:0010369,cellular_component chromocenter;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030054,cellular_component cell junction;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0034421,biological_process post-translational protein acetylation;GO:0035861,cellular_component site of double-strand break;GO:0046872,molecular_function metal ion binding;GO:0071168,biological_process protein localization to chromatin	NA	establishment of sister chromatid cohesion N-acetyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:27230]
ENSG00000156709	27.25	32.08	27.65	26.61	31.07	27.45	0.0391670337028664	5.82621944722546	0.627520223712186	0.888467670266323	X:130129361-130165887:-	AIFM1	34;GO:0002931,biological_process response to ischemia;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0009636,biological_process response to toxic substance;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016174,molecular_function NAD(P)H oxidase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0030261,biological_process chromosome condensation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0046983,molecular_function protein dimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051402,biological_process neuron apoptotic process;GO:0055114,biological_process oxidation-reduction process;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071732,biological_process cellular response to nitric oxide;GO:0071949,molecular_function FAD binding;GO:0090650,biological_process cellular response to oxygen-glucose deprivation;GO:1902065,biological_process response to L-glutamate;GO:1902510,biological_process regulation of apoptotic DNA fragmentation;GO:1904045,biological_process cellular response to aldosterone	AIFM1, PDCD8; apoptosis-inducing factor 1 [EC:1.-.-.-]; K04727	apoptosis inducing factor mitochondria associated 1 [Source:HGNC Symbol%3BAcc:HGNC:8768]
ENSG00000163322	9.71	10.55	10.01	10.53	10.35	10.57	-0.0479588936691288	4.34113099841948	0.627553890668793	0.888467670266323	4:83459516-83523348:-	ABRAXAS1	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010212,biological_process response to ionizing radiation;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031593,molecular_function polyubiquitin binding;GO:0045739,biological_process positive regulation of DNA repair;GO:0070531,cellular_component BRCA1-A complex	NA	abraxas 1%2C BRCA1 A complex subunit [Source:HGNC Symbol%3BAcc:HGNC:25829]
ENSG00000137074	35.25	36.93	36.32	37.09	35.31	39.68	-0.0377362939382485	5.30948660621642	0.627574682421262	0.888467670266323	9:32972605-33025168:-	APTX	28;GO:0000012,biological_process single strand break repair;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008967,molecular_function phosphoglycolate phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0031647,biological_process regulation of protein stability;GO:0033699,molecular_function DNA 5'-adenosine monophosphate hydrolase activity;GO:0042542,biological_process response to hydrogen peroxide;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0051219,molecular_function phosphoprotein binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	aprataxin [Source:HGNC Symbol%3BAcc:HGNC:15984]
ENSG00000204843	51.06	49.00	46.80	48.04	51.24	52.03	-0.031122304400074	7.64750823699269	0.627675914906405	0.888509651241099	2:74361153-74392087:-	DCTN1	49;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0000278,biological_process mitotic cell cycle;GO:0000776,cellular_component kinetochore;GO:0000922,cellular_component spindle pole;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005869,cellular_component dynactin complex;GO:0005874,cellular_component microtubule;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0008017,molecular_function microtubule binding;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010457,biological_process centriole-centriole cohesion;GO:0010970,biological_process establishment of localization by movement along microtubule;GO:0015629,cellular_component actin cytoskeleton;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030286,cellular_component dynein complex;GO:0030904,cellular_component retromer complex;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031252,cellular_component cell leading edge;GO:0032402,biological_process melanosome transport;GO:0034454,biological_process microtubule anchoring at centrosome;GO:0035371,cellular_component microtubule plus-end;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043234,cellular_component protein complex;GO:0051081,biological_process nuclear envelope disassembly;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0070840,molecular_function dynein complex binding;GO:0090063,biological_process positive regulation of microtubule nucleation;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0099738,cellular_component cell cortex region;GO:1905515,biological_process non-motile cilium assembly	DCTN1; dynactin 1; K04648	dynactin subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:2711]
ENSG00000150527	25.09	23.10	28.50	25.12	25.63	28.79	-0.0393439764316567	6.87945918579559	0.62815899185812	0.888711573725955	14:39230230-39388513:+	CTAGE5	12;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008047,molecular_function enzyme activator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032527,biological_process protein exit from endoplasmic reticulum;GO:0035459,biological_process cargo loading into vesicle;GO:0043085,biological_process positive regulation of catalytic activity;GO:0070971,cellular_component endoplasmic reticulum exit site;GO:0070973,biological_process protein localization to endoplasmic reticulum exit site	NA	CTAGE family member 5%2C ER export factor [Source:HGNC Symbol%3BAcc:HGNC:7057]
ENSG00000128923	3.22	4.09	4.14	3.45	4.14	4.56	-0.0831938376132932	2.9047055014859	0.628248484325783	0.888711573725955	15:58771191-58861900:+	MINDY2	17;GO:0003674,molecular_function molecular_function;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0006508,biological_process proteolysis;GO:0008150,biological_process biological_process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016807,molecular_function cysteine-type carboxypeptidase activity;GO:0036435,molecular_function K48-linked polyubiquitin binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0071795,molecular_function K11-linked polyubiquitin binding;GO:0071796,molecular_function K6-linked polyubiquitin binding;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	NA	MINDY lysine 48 deubiquitinase 2 [Source:HGNC Symbol%3BAcc:HGNC:26954]
ENSG00000166689	4.73	3.36	4.43	4.26	4.64	4.30	-0.0520941327593345	4.21398383124345	0.628266098410969	0.888711573725955	11:16777316-17014443:-	PLEKHA7	13;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005912,cellular_component adherens junction;GO:0005915,cellular_component zonula adherens;GO:0030054,cellular_component cell junction;GO:0045218,biological_process zonula adherens maintenance;GO:0070062,cellular_component extracellular exosome;GO:0070097,molecular_function delta-catenin binding;GO:0090136,biological_process epithelial cell-cell adhesion	NA	pleckstrin homology domain containing A7 [Source:HGNC Symbol%3BAcc:HGNC:27049]
ENSG00000188419	8.33	7.94	9.95	9.36	9.06	9.01	-0.047535624006824	4.15893180546877	0.62827619013578	0.888711573725955	X:85861179-86047562:-	CHM	20;GO:0004663,molecular_function Rab geranylgeranyltransferase activity;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005968,cellular_component Rab-protein geranylgeranyltransferase complex;GO:0006612,biological_process protein targeting to membrane;GO:0006886,biological_process intracellular protein transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007601,biological_process visual perception;GO:0016491,molecular_function oxidoreductase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0018344,biological_process protein geranylgeranylation;GO:0042981,biological_process regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043687,biological_process post-translational protein modification;GO:0050790,biological_process regulation of catalytic activity;GO:0050896,biological_process response to stimulus;GO:0055114,biological_process oxidation-reduction process;GO:0061024,biological_process membrane organization	NA	CHM%2C Rab escort protein 1 [Source:HGNC Symbol%3BAcc:HGNC:1940]
ENSG00000165832	14.98	14.60	14.55	13.80	14.63	14.57	0.0494313061472069	3.9416640542664	0.628293878318044	0.888711573725955	10:114938192-114977676:+	TRUB1	10;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0006396,biological_process RNA processing;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity;GO:1990481,biological_process mRNA pseudouridine synthesis	NA	TruB pseudouridine synthase family member 1 [Source:HGNC Symbol%3BAcc:HGNC:16060]
ENSG00000113742	1.43	1.68	1.79	1.45	1.40	1.74	0.0965315151537933	1.87239057941766	0.628313326786057	0.888711573725955	5:173888279-173961976:+	CPEB4	35;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0002931,biological_process response to ischemia;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0036294,biological_process cellular response to decreased oxygen levels;GO:0042149,biological_process cellular response to glucose starvation;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043022,molecular_function ribosome binding;GO:0043197,cellular_component dendritic spine;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045182,molecular_function translation regulator activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071230,biological_process cellular response to amino acid stimulus;GO:1990124,cellular_component messenger ribonucleoprotein complex;GO:2000766,biological_process negative regulation of cytoplasmic translation	NA	cytoplasmic polyadenylation element binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:21747]
ENSG00000121621	16.28	17.63	15.08	16.59	18.67	15.56	-0.0435683069164357	5.48956841164152	0.628319726981308	0.888711573725955	11:28020619-28108308:-	KIF18A	35;GO:0000166,molecular_function nucleotide binding;GO:0000776,cellular_component kinetochore;GO:0001726,cellular_component ruffle;GO:0003777,molecular_function microtubule motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005828,cellular_component kinetochore microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005901,cellular_component caveola;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007019,biological_process microtubule depolymerization;GO:0007062,biological_process sister chromatid cohesion;GO:0007080,biological_process mitotic metaphase plate congression;GO:0007140,biological_process male meiosis;GO:0008017,molecular_function microtubule binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0015031,biological_process protein transport;GO:0015630,cellular_component microtubule cytoskeleton;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042995,cellular_component cell projection;GO:0051010,molecular_function microtubule plus-end binding;GO:0070463,molecular_function tubulin-dependent ATPase activity;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0072520,biological_process seminiferous tubule development;GO:1990023,cellular_component mitotic spindle midzone	NA	kinesin family member 18A [Source:HGNC Symbol%3BAcc:HGNC:29441]
ENSG00000167842	26.99	26.57	25.73	25.57	24.54	27.21	0.0462961726418175	4.01910475769252	0.628402463993844	0.888727331155929	17:5486284-5490814:+	MIS12	17;GO:0000278,biological_process mitotic cell cycle;GO:0000444,cellular_component MIS12/MIND type complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000818,cellular_component nuclear MIS12/MIND complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0034501,biological_process protein localization to kinetochore;GO:0051301,biological_process cell division;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0051382,biological_process kinetochore assembly	NA	MIS12%2C kinetochore complex component [Source:HGNC Symbol%3BAcc:HGNC:24967]
ENSG00000141446	14.61	14.10	15.45	15.57	14.74	15.35	-0.0342299422070369	5.31440679778375	0.628552832208715	0.888838722511595	18:21529280-21600884:-	ESCO1	15;GO:0000785,cellular_component chromatin;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006275,biological_process regulation of DNA replication;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0008080,molecular_function N-acetyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018394,biological_process peptidyl-lysine acetylation;GO:0034421,biological_process post-translational protein acetylation;GO:0046872,molecular_function metal ion binding;GO:0061733,molecular_function peptide-lysine-N-acetyltransferase activity	NA	establishment of sister chromatid cohesion N-acetyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:24645]
ENSG00000163517	10.91	9.47	11.58	11.23	11.72	10.74	-0.0537150984970511	3.6128085855188	0.628866060911187	0.88898846483748	3:13479723-13506424:+	HDAC11	15;GO:0000118,cellular_component histone deacetylase complex;GO:0004407,molecular_function histone deacetylase activity;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0014003,biological_process oligodendrocyte development;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0070062,cellular_component extracellular exosome;GO:0070932,biological_process histone H3 deacetylation	HDAC11; histone deacetylase 11 [EC:3.5.1.98]; K11418	histone deacetylase 11 [Source:HGNC Symbol%3BAcc:HGNC:19086]
ENSG00000111653	58.11	64.53	68.12	64.40	67.76	65.08	-0.0375931003080906	5.65945157421751	0.628884066697231	0.88898846483748	12:6650279-6663148:-	ING4	23;GO:0000123,cellular_component histone acetyltransferase complex;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006473,biological_process protein acetylation;GO:0006915,biological_process apoptotic process;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0035064,molecular_function methylated histone binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043966,biological_process histone H3 acetylation;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043983,biological_process histone H4-K12 acetylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045926,biological_process negative regulation of growth;GO:0046872,molecular_function metal ion binding	NA	inhibitor of growth family member 4 [Source:HGNC Symbol%3BAcc:HGNC:19423]
ENSG00000085563	3.55	4.43	3.60	3.20	4.35	3.59	0.0612221014819153	3.86998023714544	0.628893273113952	0.88898846483748	7:87503632-87713323:-	ABCB1	29;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0008559,molecular_function xenobiotic-transporting ATPase activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042908,biological_process xenobiotic transport;GO:0045332,biological_process phospholipid translocation;GO:0047484,biological_process regulation of response to osmotic stress;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0072089,biological_process stem cell proliferation;GO:0090554,molecular_function phosphatidylcholine-translocating ATPase activity;GO:0090555,molecular_function phosphatidylethanolamine-translocating ATPase activity;GO:0099038,molecular_function ceramide-translocating ATPase activity;GO:0099040,biological_process ceramide translocation;GO:1901529,biological_process positive regulation of anion channel activity;GO:2001225,biological_process regulation of chloride transport	ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2]; K05658	ATP binding cassette subfamily B member 1 [Source:HGNC Symbol%3BAcc:HGNC:40]
ENSG00000276023	36.50	33.30	37.67	38.44	35.75	37.65	-0.0403300914242066	4.45416007966109	0.628945194409308	0.88898846483748	17:37489830-37513501:+	DUSP14	12;GO:0000188,biological_process inactivation of MAPK activity;GO:0003723,molecular_function RNA binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 14 [Source:HGNC Symbol%3BAcc:HGNC:17007]
ENSG00000084676	7.33	7.03	8.18	7.79	7.94	7.65	-0.0371851557019499	5.07104770946915	0.629144921705626	0.889169522160075	2:24491913-24770702:+	NCOA1	62;GO:0000435,biological_process positive regulation of transcription from RNA polymerase II promoter by galactose;GO:0000790,cellular_component nuclear chromatin;GO:0001012,molecular_function RNA polymerase II regulatory region DNA binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0002155,biological_process regulation of thyroid hormone mediated signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007595,biological_process lactation;GO:0008134,molecular_function transcription factor binding;GO:0008584,biological_process male gonad development;GO:0009725,biological_process response to hormone;GO:0015721,biological_process bile acid and bile salt transport;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0021549,biological_process cerebellum development;GO:0021766,biological_process hippocampus development;GO:0021854,biological_process hypothalamus development;GO:0021987,biological_process cerebral cortex development;GO:0030331,molecular_function estrogen receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0032526,biological_process response to retinoic acid;GO:0032570,biological_process response to progesterone;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033142,molecular_function progesterone receptor binding;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0042974,molecular_function retinoic acid receptor binding;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043967,biological_process histone H4 acetylation;GO:0044849,biological_process estrous cycle;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045925,biological_process positive regulation of female receptivity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046965,molecular_function retinoid X receptor binding;GO:0046983,molecular_function protein dimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0050681,molecular_function androgen receptor binding;GO:0060179,biological_process male mating behavior;GO:0060713,biological_process labyrinthine layer morphogenesis;GO:1904017,biological_process cellular response to Thyroglobulin triiodothyronine;GO:2001038,biological_process regulation of cellular response to drug;GO:2001141,biological_process regulation of RNA biosynthetic process	NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1 [EC:2.3.1.48]; K09101	nuclear receptor coactivator 1 [Source:HGNC Symbol%3BAcc:HGNC:7668]
ENSG00000164494	11.24	11.87	10.83	11.08	12.41	11.87	-0.0515171141261326	3.97064026498487	0.629345164946428	0.889351267358836	6:107152556-107459564:-	PDSS2	12;GO:0000010,molecular_function trans-hexaprenyltranstransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0050347,molecular_function trans-octaprenyltranstransferase activity;GO:0050878,biological_process regulation of body fluid levels;GO:0051290,biological_process protein heterotetramerization;GO:1990234,cellular_component transferase complex	PDSS2; decaprenyl-diphosphate synthase subunit 2 [EC:2.5.1.91]; K12505	decaprenyl diphosphate synthase subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:23041]
ENSG00000149016	3.63	4.36	3.38	3.66	3.07	4.12	0.065952240187559	3.37159084728636	0.62943945797303	0.88938326600105	11:62575044-62592177:-	TUT1	21;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0004652,molecular_function polynucleotide adenylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006378,biological_process mRNA polyadenylation;GO:0006397,biological_process mRNA processing;GO:0016180,biological_process snRNA processing;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019899,molecular_function enzyme binding;GO:0046872,molecular_function metal ion binding;GO:0050265,molecular_function RNA uridylyltransferase activity;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation	NA	terminal uridylyl transferase 1%2C U6 snRNA-specific [Source:HGNC Symbol%3BAcc:HGNC:26184]
ENSG00000070367	29.03	28.61	30.73	29.17	30.68	31.30	-0.0317284682997898	6.00626166542519	0.629512777448377	0.889385625593752	14:57200506-57269008:-	EXOC5	13;GO:0000145,cellular_component exocyst;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0015031,biological_process protein transport;GO:0017160,molecular_function Ral GTPase binding;GO:0030496,cellular_component midbody;GO:0047485,molecular_function protein N-terminus binding;GO:0048278,biological_process vesicle docking	NA	exocyst complex component 5 [Source:HGNC Symbol%3BAcc:HGNC:10696]
ENSG00000006744	25.85	29.10	25.13	25.65	28.15	24.76	0.036343498362303	6.05801842579888	0.630100941077736	0.889934702110137	17:12992390-13018187:-	ELAC2	16;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004549,molecular_function tRNA-specific ribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0042645,cellular_component mitochondrial nucleoid;GO:0042780,biological_process tRNA 3'-end processing;GO:0042781,molecular_function 3'-tRNA processing endoribonuclease activity;GO:0046872,molecular_function metal ion binding;GO:0072684,biological_process mitochondrial tRNA 3'-trailer cleavage, endonucleolytic;GO:0090646,biological_process mitochondrial tRNA processing	rnz; ribonuclease Z [EC:3.1.26.11]; K00784	elaC ribonuclease Z 2 [Source:HGNC Symbol%3BAcc:HGNC:14198]
ENSG00000178035	153.66	151.21	149.84	159.38	145.82	163.09	-0.0306857316569982	7.95952674042141	0.630103024315257	0.889934702110137	3:49024324-49029408:-	IMPDH2	27;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0003938,molecular_function IMP dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005778,cellular_component peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006177,biological_process GMP biosynthetic process;GO:0006183,biological_process GTP biosynthetic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046651,biological_process lymphocyte proliferation;GO:0046872,molecular_function metal ion binding;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0060041,biological_process retina development in camera-type eye;GO:0070062,cellular_component extracellular exosome;GO:0071353,biological_process cellular response to interleukin-4;GO:1904813,cellular_component ficolin-1-rich granule lumen	IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]; K00088	inosine monophosphate dehydrogenase 2 [Source:HGNC Symbol%3BAcc:HGNC:6053]
ENSG00000118900	17.09	17.70	17.69	17.67	17.28	16.82	0.0308522818800082	5.94047899810534	0.630163877165804	0.889934702110137	16:4846664-4882360:+	UBN1	15;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005923,cellular_component bicellular tight junction;GO:0006325,biological_process chromatin organization;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0030054,cellular_component cell junction	NA	ubinuclein 1 [Source:HGNC Symbol%3BAcc:HGNC:12506]
ENSG00000104899	8.53	7.28	7.62	8.51	7.09	9.08	-0.0591978103320494	3.77405277614288	0.630188192342553	0.889934702110137	19:2249308-2252073:+	AMH	22;GO:0001546,biological_process preantral ovarian follicle growth;GO:0001655,biological_process urogenital system development;GO:0001880,biological_process Mullerian duct regression;GO:0005102,molecular_function receptor binding;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007267,biological_process cell-cell signaling;GO:0007506,biological_process gonadal mesoderm development;GO:0007530,biological_process sex determination;GO:0007548,biological_process sex differentiation;GO:0007568,biological_process aging;GO:0008083,molecular_function growth factor activity;GO:0008406,biological_process gonad development;GO:0010628,biological_process positive regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0030154,biological_process cell differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0042493,biological_process response to drug;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:2000355,biological_process negative regulation of ovarian follicle development	AMH; anti-mullerian hormone; K04665	anti-Mullerian hormone [Source:HGNC Symbol%3BAcc:HGNC:464]
ENSG00000119686	3.79	4.45	3.59	3.57	3.86	3.89	0.0616830647452078	2.8410629834632	0.630343126035047	0.890052237910708	14:75578616-75663214:+	FLVCR2	8;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015232,molecular_function heme transporter activity;GO:0015886,biological_process heme transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0020037,molecular_function heme binding;GO:0055085,biological_process transmembrane transport	NA	feline leukemia virus subgroup C cellular receptor family member 2 [Source:HGNC Symbol%3BAcc:HGNC:20105]
ENSG00000113812	19.79	21.53	19.31	19.44	19.41	20.64	0.0339786779982715	5.24741680212376	0.630586131138372	0.890294090743928	3:53867065-53882202:-	ACTR8	17;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005813,cellular_component centrosome;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0031011,cellular_component Ino80 complex;GO:0051301,biological_process cell division	NA	ARP8 actin related protein 8 homolog [Source:HGNC Symbol%3BAcc:HGNC:14672]
ENSG00000168661	3.20	2.65	2.28	2.12	2.59	2.96	0.0968141909649658	2.35109382027142	0.63093538215409	0.890685874977678	19:34926902-34945170:+	ZNF30	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 30 [Source:HGNC Symbol%3BAcc:HGNC:13090]
ENSG00000114268	11.34	10.69	12.33	12.76	12.66	10.56	-0.0487811454828147	4.35124211521318	0.631226933492595	0.890696846796115	3:48517683-48562015:-	PFKFB4	16;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003873,molecular_function 6-phosphofructo-2-kinase activity;GO:0004331,molecular_function fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006000,biological_process fructose metabolic process;GO:0006003,biological_process fructose 2,6-bisphosphate metabolic process;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0045821,biological_process positive regulation of glycolytic process;GO:0046835,biological_process carbohydrate phosphorylation	PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]; K01103	6-phosphofructo-2-kinase/fructose-2%2C6-biphosphatase 4 [Source:HGNC Symbol%3BAcc:HGNC:8875]
ENSG00000206418	57.60	52.87	59.42	59.63	55.43	60.81	-0.0347246035009821	5.40667881756059	0.631516834815745	0.890696846796115	18:8609444-8639381:+	RAB12	22;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0019003,molecular_function GDP binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0044257,biological_process cellular protein catabolic process;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization	NA	RAB12%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:31332]
ENSG00000155463	105.19	100.41	100.00	106.32	101.98	106.18	-0.0292872895733629	7.27883691369358	0.631553669624731	0.890696846796115	14:22766521-22773041:+	OXA1L	21;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0006461,biological_process protein complex assembly;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032592,cellular_component integral component of mitochondrial membrane;GO:0032780,biological_process negative regulation of ATPase activity;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0033615,biological_process mitochondrial proton-transporting ATP synthase complex assembly;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0051205,biological_process protein insertion into membrane;GO:0051262,biological_process protein tetramerization;GO:0051354,biological_process negative regulation of oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0097031,biological_process mitochondrial respiratory chain complex I biogenesis;GO:0097177,molecular_function mitochondrial ribosome binding	yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase; K03217	OXA1L%2C mitochondrial inner membrane protein [Source:HGNC Symbol%3BAcc:HGNC:8526]
ENSG00000069974	39.63	39.06	31.64	38.85	33.06	43.59	-0.0578662371357944	4.65077932244175	0.631557562567756	0.890696846796115	15:55202965-55319113:-	RAB27A	53;GO:0000166,molecular_function nucleotide binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006605,biological_process protein targeting;GO:0006887,biological_process exocytosis;GO:0007596,biological_process blood coagulation;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016324,cellular_component apical plasma membrane;GO:0019003,molecular_function GDP binding;GO:0019882,biological_process antigen processing and presentation;GO:0019904,molecular_function protein domain specific binding;GO:0030141,cellular_component secretory granule;GO:0030318,biological_process melanocyte differentiation;GO:0030425,cellular_component dendrite;GO:0030667,cellular_component secretory granule membrane;GO:0031489,molecular_function myosin V binding;GO:0032400,biological_process melanosome localization;GO:0032402,biological_process melanosome transport;GO:0032585,cellular_component multivesicular body membrane;GO:0033093,cellular_component Weibel-Palade body;GO:0033162,cellular_component melanosome membrane;GO:0035580,cellular_component specific granule lumen;GO:0036257,biological_process multivesicular body organization;GO:0042470,cellular_component melanosome;GO:0043312,biological_process neutrophil degranulation;GO:0043316,biological_process cytotoxic T cell degranulation;GO:0043320,biological_process natural killer cell degranulation;GO:0043473,biological_process pigmentation;GO:0045202,cellular_component synapse;GO:0045921,biological_process positive regulation of exocytosis;GO:0048489,biological_process synaptic vesicle transport;GO:0050766,biological_process positive regulation of phagocytosis;GO:0051875,biological_process pigment granule localization;GO:0051904,biological_process pigment granule transport;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070382,cellular_component exocytic vesicle;GO:0071985,biological_process multivesicular body sorting pathway;GO:0097278,biological_process complement-dependent cytotoxicity;GO:1903307,biological_process positive regulation of regulated secretory pathway;GO:1903428,biological_process positive regulation of reactive oxygen species biosynthetic process;GO:1903435,biological_process positive regulation of constitutive secretory pathway;GO:1990182,biological_process exosomal secretion	NA	RAB27A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9766]
ENSG00000254093	3.06	2.98	2.78	3.04	2.58	2.65	0.104427122176139	1.66326788522375	0.631713471354041	0.890696846796115	8:10764962-10839884:-	PINX1	29;GO:0000228,cellular_component nuclear chromosome;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005819,cellular_component spindle;GO:0007004,biological_process telomere maintenance via telomerase;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010521,molecular_function telomerase inhibitor activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031647,biological_process regulation of protein stability;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0044877,molecular_function macromolecular complex binding;GO:0051972,biological_process regulation of telomerase activity;GO:0051974,biological_process negative regulation of telomerase activity;GO:0070034,molecular_function telomerase RNA binding;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:1902570,biological_process protein localization to nucleolus;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1904744,biological_process positive regulation of telomeric DNA binding;GO:1904751,biological_process positive regulation of protein localization to nucleolus	NA	PIN2/TERF1 interacting telomerase inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:30046]
ENSG00000170234	7.35	7.45	7.51	7.31	7.43	8.48	-0.0482438505193071	4.25278638701984	0.631728020738698	0.890696846796115	5:160061800-160119423:-	PWWP2A	1;GO:0005515,molecular_function protein binding	NA	PWWP domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:29406]
ENSG00000164609	35.15	31.47	29.31	31.22	33.65	34.44	-0.037230477145914	5.84358291127553	0.631748939993331	0.890696846796115	5:160401640-160421711:-	SLU7	28;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000386,molecular_function second spliceosomal transesterification activity;GO:0000389,biological_process mRNA 3'-splice site recognition;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006886,biological_process intracellular protein transport;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0030628,molecular_function pre-mRNA 3'-splice site binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0034605,biological_process cellular response to heat;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0071013,cellular_component catalytic step 2 spliceosome	SLU7; pre-mRNA-processing factor SLU7; K12819	SLU7 homolog%2C splicing factor [Source:HGNC Symbol%3BAcc:HGNC:16939]
ENSG00000135250	29.07	27.73	28.52	31.24	27.31	29.51	-0.0329531754926336	6.17235085622853	0.631818218808968	0.890696846796115	7:105110703-105399308:-	SRPK2	32;GO:0000166,molecular_function nucleotide binding;GO:0000245,biological_process spliceosomal complex assembly;GO:0000287,molecular_function magnesium ion binding;GO:0001525,biological_process angiogenesis;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008380,biological_process RNA splicing;GO:0010628,biological_process positive regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0035063,biological_process nuclear speck organization;GO:0035556,biological_process intracellular signal transduction;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045787,biological_process positive regulation of cell cycle;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0071889,molecular_function 14-3-3 protein binding	NA	SRSF protein kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:11306]
ENSG00000243335	16.13	16.52	17.04	15.97	16.66	16.00	0.0428942860403202	4.38000008068698	0.631832349610146	0.890696846796115	7:66628766-66649067:+	KCTD7	6;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0043687,biological_process post-translational protein modification;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:21957]
ENSG00000035687	42.70	43.31	43.47	42.53	41.03	44.15	0.0307593661066992	5.87831550560614	0.631836982523603	0.890696846796115	1:244408493-244452134:-	ADSS	22;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0002376,biological_process immune system process;GO:0004019,molecular_function adenylosuccinate synthase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006167,biological_process AMP biosynthetic process;GO:0006531,biological_process aspartate metabolic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0014074,biological_process response to purine-containing compound;GO:0016874,molecular_function ligase activity;GO:0042301,molecular_function phosphate ion binding;GO:0044208,biological_process 'de novo' AMP biosynthetic process;GO:0046040,biological_process IMP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0060359,biological_process response to ammonium ion;GO:0070062,cellular_component extracellular exosome;GO:0071257,biological_process cellular response to electrical stimulus	purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]; K01939	adenylosuccinate synthase [Source:HGNC Symbol%3BAcc:HGNC:292]
ENSG00000094914	25.45	26.63	25.49	23.92	26.87	25.47	0.0344701324888401	5.39899073865716	0.631881949873276	0.890696846796115	12:53307455-53324864:-	AAAS	27;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007612,biological_process learning;GO:0009566,biological_process fertilization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0046822,biological_process regulation of nucleocytoplasmic transport;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	AAAS; aladin; K14320	aladin WD repeat nucleoporin [Source:HGNC Symbol%3BAcc:HGNC:13666]
ENSG00000136490	13.72	17.56	16.81	16.70	12.34	16.43	0.0805368634708559	2.60230195033763	0.63194658581697	0.890696846796115	17:63695901-63701172:-	LIMD2	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0046872,molecular_function metal ion binding	NA	LIM domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28142]
ENSG00000149474	13.91	13.77	14.34	14.65	14.84	13.97	-0.0351564575549375	5.07041029263678	0.632011547312795	0.890696846796115	20:18138117-18188387:+	KAT14	10;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0005737,cellular_component cytoplasm;GO:0008080,molecular_function N-acetyltransferase activity;GO:0016573,biological_process histone acetylation;GO:0030274,molecular_function LIM domain binding;GO:0043966,biological_process histone H3 acetylation	NA	lysine acetyltransferase 14 [Source:HGNC Symbol%3BAcc:HGNC:15904]
ENSG00000164332	23.39	24.04	25.54	21.50	24.80	24.99	0.044959165648332	4.53012404237908	0.632155772484977	0.890696846796115	5:159263080-159286040:+	UBLCP1	7;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006470,biological_process protein dephosphorylation;GO:0016787,molecular_function hydrolase activity	NA	ubiquitin like domain containing CTD phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:28110]
ENSG00000070214	53.72	56.07	51.40	52.62	52.66	53.70	0.0301725508246312	6.73222432132724	0.632245251910537	0.890696846796115	9:105244621-105439171:+	SLC44A1	13;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005886,cellular_component plasma membrane;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006810,biological_process transport;GO:0015220,molecular_function choline transmembrane transporter activity;GO:0015871,biological_process choline transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042426,biological_process choline catabolic process;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	SLC44A1, CD92; solute carrier family 44 (choline transporter-like protein), member 1; K06515	solute carrier family 44 member 1 [Source:HGNC Symbol%3BAcc:HGNC:18798]
ENSG00000142186	44.10	44.48	44.00	45.04	43.67	42.16	0.0305035965336002	6.75024212682829	0.632283136633862	0.890696846796115	11:65525076-65538704:+	SCYL1	22;GO:0003677,molecular_function DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030126,cellular_component COPI vesicle coat;GO:0045296,molecular_function cadherin binding	NA	SCY1 like pseudokinase 1 [Source:HGNC Symbol%3BAcc:HGNC:14372]
ENSG00000174446	18.48	14.92	21.12	19.74	18.72	19.43	-0.0613364003830885	3.18446206735577	0.632343436101874	0.890696846796115	15:66490134-66497813:-	SNAPC5	11;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006384,biological_process transcription initiation from RNA polymerase III promoter;GO:0016604,cellular_component nuclear body;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	small nuclear RNA activating complex polypeptide 5 [Source:HGNC Symbol%3BAcc:HGNC:15484]
ENSG00000187210	34.38	34.46	33.82	37.32	33.61	35.05	-0.0347181895718385	5.48636931640574	0.632365315995802	0.890696846796115	9:76419849-76507416:+	GCNT1	20;GO:0000139,cellular_component Golgi membrane;GO:0003829,molecular_function beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006486,biological_process protein glycosylation;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0009101,biological_process glycoprotein biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0031985,cellular_component Golgi cisterna;GO:0032868,biological_process response to insulin;GO:0048729,biological_process tissue morphogenesis;GO:0050901,biological_process leukocyte tethering or rolling;GO:0060352,biological_process cell adhesion molecule production;GO:0060993,biological_process kidney morphogenesis	GCNT1; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase [EC:2.4.1.102]; K00727	glucosaminyl (N-acetyl) transferase 1%2C core 2 [Source:HGNC Symbol%3BAcc:HGNC:4203]
ENSG00000177058	5.41	5.65	6.01	6.16	5.47	6.34	-0.06328908910482	3.39712130948603	0.632392028707789	0.890696846796115	5:55625844-55773194:-	SLC38A9	19;GO:0003333,biological_process amino acid transmembrane transport;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0007050,biological_process cell cycle arrest;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0031902,cellular_component late endosome membrane;GO:0032008,biological_process positive regulation of TOR signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071986,cellular_component Ragulator complex	SLC38A9; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9; K14995	solute carrier family 38 member 9 [Source:HGNC Symbol%3BAcc:HGNC:26907]
ENSG00000136868	33.45	34.03	33.06	33.89	34.33	36.15	-0.04442402574212	4.29510569754083	0.632481020226345	0.890696846796115	9:113221561-113264492:+	SLC31A1	19;GO:0005375,molecular_function copper ion transmembrane transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006825,biological_process copper ion transport;GO:0006855,biological_process drug transmembrane transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0015088,molecular_function copper uptake transmembrane transporter activity;GO:0015677,biological_process copper ion import;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035434,biological_process copper ion transmembrane transport;GO:0043025,cellular_component neuronal cell body;GO:0055037,cellular_component recycling endosome;GO:0072719,biological_process cellular response to cisplatin;GO:0098705,biological_process copper ion import across plasma membrane	SLC31A1, CTR1; solute carrier family 31 (copper transporter), member 1; K14686	solute carrier family 31 member 1 [Source:HGNC Symbol%3BAcc:HGNC:11016]
ENSG00000160633	37.87	37.66	36.31	37.83	37.53	34.94	0.0317292033097072	6.6887255622873	0.632554060567849	0.890696846796115	19:5623034-5668478:+	SAFB	19;GO:0001047,molecular_function core promoter binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:0040007,biological_process growth;GO:0042445,biological_process hormone metabolic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050684,biological_process regulation of mRNA processing	NA	scaffold attachment factor B [Source:HGNC Symbol%3BAcc:HGNC:10520]
ENSG00000189046	14.95	10.24	14.65	15.28	11.61	15.61	-0.0701072229318025	3.46057024515506	0.63262326807812	0.890696846796115	12:109088187-109093631:-	ALKBH2	18;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008198,molecular_function ferrous iron binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016491,molecular_function oxidoreductase activity;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0035511,biological_process oxidative DNA demethylation;GO:0043734,molecular_function DNA-N1-methyladenine dioxygenase activity;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051747,molecular_function cytosine C-5 DNA demethylase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070989,biological_process oxidative demethylation;GO:0080111,biological_process DNA demethylation;GO:0103053,molecular_function 1-ethyladenine demethylase activity	NA	alkB homolog 2%2C alpha-ketoglutarate dependent dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:32487]
ENSG00000100380	268.32	279.48	268.37	273.27	285.57	280.15	-0.028365335079601	8.27921633273748	0.632706868431873	0.890696846796115	22:40824534-40857022:-	ST13	18;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0019904,molecular_function protein domain specific binding;GO:0030544,molecular_function Hsp70 protein binding;GO:0030674,molecular_function protein binding, bridging;GO:0032403,molecular_function protein complex binding;GO:0032564,molecular_function dATP binding;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0046983,molecular_function protein dimerization activity;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051260,biological_process protein homooligomerization;GO:0061084,biological_process negative regulation of protein refolding;GO:0070062,cellular_component extracellular exosome;GO:0070389,biological_process chaperone cofactor-dependent protein refolding	NA	ST13%2C Hsp70 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:11343]
ENSG00000128487	18.01	16.73	16.76	17.50	15.39	17.78	0.0359106865739212	5.83582519091934	0.63271027815374	0.890696846796115	17:20009343-20319026:+	SPECC1	2;GO:0005634,cellular_component nucleus;GO:0016020,cellular_component membrane	NA	sperm antigen with calponin homology and coiled-coil domains 1 [Source:HGNC Symbol%3BAcc:HGNC:30615]
ENSG00000138032	67.45	65.27	66.44	65.40	67.85	71.99	-0.0312157151718105	6.6340053574096	0.632826798172227	0.890696846796115	2:44167968-44244384:+	PPM1B	20;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006499,biological_process N-terminal protein myristoylation;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding;GO:0050687,biological_process negative regulation of defense response to virus	PPM1B, PP2CB; protein phosphatase 1B [EC:3.1.3.16]; K04461	protein phosphatase%2C Mg2+/Mn2+ dependent 1B [Source:HGNC Symbol%3BAcc:HGNC:9276]
ENSG00000112514	138.60	150.65	146.22	139.81	148.43	141.11	0.0309957141951326	6.75086661834815	0.632910149987993	0.890696846796115	6:33416441-33418317:-	CUTA	8;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0008104,biological_process protein localization;GO:0010038,biological_process response to metal ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0070062,cellular_component extracellular exosome	NA	cutA divalent cation tolerance homolog [Source:HGNC Symbol%3BAcc:HGNC:21101]
ENSG00000151746	10.03	10.71	9.01	10.25	10.51	10.03	-0.0426603171588881	5.00447648780907	0.632960365627319	0.890696846796115	12:32106834-32383633:+	BICD1	30;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006396,biological_process RNA processing;GO:0006810,biological_process transport;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008298,biological_process intracellular mRNA localization;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0017137,molecular_function Rab GTPase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031871,molecular_function proteinase activated receptor binding;GO:0033365,biological_process protein localization to organelle;GO:0034063,biological_process stress granule assembly;GO:0034452,molecular_function dynactin binding;GO:0045298,cellular_component tubulin complex;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070840,molecular_function dynein complex binding;GO:0072385,biological_process minus-end-directed organelle transport along microtubule;GO:0072393,biological_process microtubule anchoring at microtubule organizing center;GO:0072517,cellular_component host cell viral assembly compartment;GO:1900275,biological_process negative regulation of phospholipase C activity;GO:1900276,biological_process regulation of proteinase activated receptor activity;GO:1900737,biological_process negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway	NA	BICD cargo adaptor 1 [Source:HGNC Symbol%3BAcc:HGNC:1049]
ENSG00000165185	4.78	4.91	4.98	4.60	4.92	4.78	0.0481353738856423	3.95991582260973	0.632977986119565	0.890696846796115	9:112486846-112669397:+	KIAA1958	6;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter	NA	KIAA1958 [Source:HGNC Symbol%3BAcc:HGNC:23427]
ENSG00000174442	16.73	18.18	14.95	16.47	16.86	15.35	0.0413878414258424	4.87220079159432	0.633024054010741	0.890696846796115	15:66504958-66550128:+	ZWILCH	11;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0051301,biological_process cell division;GO:1990423,cellular_component RZZ complex	NA	zwilch kinetochore protein [Source:HGNC Symbol%3BAcc:HGNC:25468]
ENSG00000134698	6.40	6.10	5.98	6.32	5.67	7.35	-0.0545501611220618	4.04194009550275	0.633207209421558	0.89074088584921	1:35808171-35857890:+	AGO4	36;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006402,biological_process mRNA catabolic process;GO:0006417,biological_process regulation of translation;GO:0007130,biological_process synaptonemal complex assembly;GO:0007140,biological_process male meiosis;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0008584,biological_process male gonad development;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010586,biological_process miRNA metabolic process;GO:0016020,cellular_component membrane;GO:0016442,cellular_component RISC complex;GO:0016604,cellular_component nuclear body;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035194,biological_process posttranscriptional gene silencing by RNA;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0035198,molecular_function miRNA binding;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0035280,biological_process miRNA loading onto RISC involved in gene silencing by miRNA;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0070578,cellular_component RISC-loading complex	ELF2C, AGO; eukaryotic translation initiation factor 2C; K11593	argonaute 4%2C RISC catalytic component [Source:HGNC Symbol%3BAcc:HGNC:18424]
ENSG00000081320	13.54	13.79	12.99	13.62	13.32	12.35	0.0481033494276587	3.90183907183603	0.633274786881747	0.89074088584921	2:196133565-196176503:-	STK17B	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0012501,biological_process programmed cell death;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0046777,biological_process protein autophosphorylation;GO:2000271,biological_process positive regulation of fibroblast apoptotic process	NA	serine/threonine kinase 17b [Source:HGNC Symbol%3BAcc:HGNC:11396]
ENSG00000167378	1.89	1.84	1.65	1.76	1.70	2.33	-0.102074976687266	1.86651788779283	0.633284070420879	0.89074088584921	19:43584368-43596135:-	IRGQ	1;GO:0005525,molecular_function GTP binding	NA	immunity related GTPase Q [Source:HGNC Symbol%3BAcc:HGNC:24868]
ENSG00000197045	52.71	53.79	54.30	55.56	50.78	51.28	0.040297226503772	4.64642949041116	0.633342387698794	0.89074088584921	14:54474483-54489196:-	GMFB	15;GO:0003779,molecular_function actin binding;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004871,molecular_function signal transducer activity;GO:0005622,cellular_component intracellular;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0007612,biological_process learning;GO:0007626,biological_process locomotory behavior;GO:0008047,molecular_function enzyme activator activity;GO:0008083,molecular_function growth factor activity;GO:0034316,biological_process negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0043085,biological_process positive regulation of catalytic activity;GO:0071933,molecular_function Arp2/3 complex binding	NA	glia maturation factor beta [Source:HGNC Symbol%3BAcc:HGNC:4373]
ENSG00000148356	15.47	14.28	16.15	15.67	14.69	17.28	-0.0393173021229563	5.08936948793335	0.6334974578602	0.890837957693201	9:127451485-127503501:+	LRSAM1	22;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0007165,biological_process signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030163,biological_process protein catabolic process;GO:0045806,biological_process negative regulation of endocytosis;GO:0046755,biological_process viral budding;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070086,biological_process ubiquitin-dependent endocytosis;GO:1904417,biological_process positive regulation of xenophagy;GO:2000786,biological_process positive regulation of autophagosome assembly	NA	leucine rich repeat and sterile alpha motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25135]
ENSG00000166295	189.19	184.47	183.78	187.86	191.44	170.04	0.0339660202295922	5.93201829012791	0.633554941635026	0.890837957693201	10:72215999-72235860:+	ANAPC16	18;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	NA	anaphase promoting complex subunit 16 [Source:HGNC Symbol%3BAcc:HGNC:26976]
ENSG00000213995	9.85	11.24	12.54	9.84	11.01	11.69	0.0565071509864325	3.78119649488318	0.633746325662891	0.890990704327635	13:110615459-110639993:+	NAXD	13;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008150,biological_process biological_process;GO:0016829,molecular_function lyase activity;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0046496,biological_process nicotinamide nucleotide metabolic process;GO:0047453,molecular_function ATP-dependent NAD(P)H-hydrate dehydratase activity;GO:0052855,molecular_function ADP-dependent NAD(P)H-hydrate dehydratase activity	NA	NAD(P)HX dehydratase [Source:HGNC Symbol%3BAcc:HGNC:25576]
ENSG00000154473	110.73	112.64	112.97	117.91	114.52	113.69	-0.0297804641078861	6.83534882998446	0.633807131169984	0.890990704327635	10:123154276-123170467:+	BUB3	26;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0033597,cellular_component mitotic checkpoint complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051321,biological_process meiotic cell cycle;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051983,biological_process regulation of chromosome segregation;GO:0071173,biological_process spindle assembly checkpoint;GO:1990298,cellular_component bub1-bub3 complex	BUB3; cell cycle arrest protein BUB3; K02180	BUB3%2C mitotic checkpoint protein [Source:HGNC Symbol%3BAcc:HGNC:1151]
ENSG00000259956	29.49	29.60	25.83	27.62	28.69	27.26	0.0336089633665798	6.23139339983396	0.634192455462237	0.89143142901741	3:51391267-51397908:+	RBM15B	11;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016032,biological_process viral process	NA	RNA binding motif protein 15B [Source:HGNC Symbol%3BAcc:HGNC:24303]
ENSG00000070778	9.19	7.86	8.94	9.24	9.21	8.56	-0.0367836755711045	4.99081895222037	0.634326816950622	0.891452681607676	14:88465777-88554733:-	PTPN21	10;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006470,biological_process protein dephosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation	NA	protein tyrosine phosphatase%2C non-receptor type 21 [Source:HGNC Symbol%3BAcc:HGNC:9651]
ENSG00000067177	15.53	13.00	14.25	14.13	13.44	14.54	0.0386781054003901	5.72468584633947	0.634404221687145	0.891452681607676	X:72578813-72714319:-	PHKA1	12;GO:0003824,molecular_function catalytic activity;GO:0004689,molecular_function phosphorylase kinase activity;GO:0005516,molecular_function calmodulin binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005964,cellular_component phosphorylase kinase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005980,biological_process glycogen catabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane	PHKA_B; phosphorylase kinase alpha/beta subunit; K07190	phosphorylase kinase regulatory subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:8925]
ENSG00000196730	42.66	38.60	44.56	40.80	41.12	42.19	0.0326952086056299	7.48417447245552	0.634423023388561	0.891452681607676	9:87497227-87708633:+	DAPK1	35;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0010506,biological_process regulation of autophagy;GO:0010508,biological_process positive regulation of autophagy;GO:0015629,cellular_component actin cytoskeleton;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017075,molecular_function syntaxin-1 binding;GO:0017148,biological_process negative regulation of translation;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046777,biological_process protein autophosphorylation;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071447,biological_process cellular response to hydroperoxide;GO:0097190,biological_process apoptotic signaling pathway;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity	DAPK; death-associated protein kinase [EC:2.7.11.1]; K08803	death associated protein kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:2674]
ENSG00000144834	2.94	5.84	3.64	2.82	5.62	2.74	0.144165812856254	1.63750736530355	0.634525108203169	0.891495208616406	3:111998663-112013887:+	TAGLN3	5;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005634,cellular_component nucleus;GO:0007417,biological_process central nervous system development;GO:0043209,cellular_component myelin sheath;GO:0051015,molecular_function actin filament binding	NA	transgelin 3 [Source:HGNC Symbol%3BAcc:HGNC:29868]
ENSG00000182606	10.36	11.87	11.42	11.22	12.94	10.75	-0.0432489132802436	5.33347195395418	0.63460275964869	0.891503401484743	3:42013801-42225889:+	TRAK1	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006493,biological_process protein O-linked glycosylation;GO:0006605,biological_process protein targeting;GO:0008333,biological_process endosome to lysosome transport;GO:0050811,molecular_function GABA receptor binding;GO:0098957,biological_process anterograde axonal transport of mitochondrion;GO:1904115,cellular_component axon cytoplasm	NA	trafficking kinesin protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29947]
ENSG00000013275	46.86	48.39	46.37	49.20	48.51	48.06	-0.0312950762692862	5.9125302847063	0.634799105947295	0.891510136177514	19:39971004-39981441:+	PSMC4	49;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0001824,biological_process blastocyst development;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016234,cellular_component inclusion body;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017025,molecular_function TBP-class protein binding;GO:0022624,cellular_component proteasome accessory complex;GO:0030163,biological_process protein catabolic process;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031595,cellular_component nuclear proteasome complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0036402,molecular_function proteasome-activating ATPase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045202,cellular_component synapse;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	NA	proteasome 26S subunit%2C ATPase 4 [Source:HGNC Symbol%3BAcc:HGNC:9551]
ENSG00000196296	1.41	1.63	1.64	1.35	1.05	1.97	0.0999938828461607	2.27434974771872	0.63481589611635	0.891510136177514	16:28878404-28904509:+	ATP2A1	34;GO:0000166,molecular_function nucleotide binding;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016787,molecular_function hydrolase activity;GO:0031095,cellular_component platelet dense tubular network membrane;GO:0031448,biological_process positive regulation of fast-twitch skeletal muscle fiber contraction;GO:0032470,biological_process positive regulation of endoplasmic reticulum calcium ion concentration;GO:0032471,biological_process negative regulation of endoplasmic reticulum calcium ion concentration;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034220,biological_process ion transmembrane transport;GO:0034704,cellular_component calcium channel complex;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0051659,biological_process maintenance of mitochondrion location;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070509,biological_process calcium ion import;GO:0070588,biological_process calcium ion transmembrane transport;GO:0090076,biological_process relaxation of skeletal muscle;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport;GO:1903779,biological_process regulation of cardiac conduction	ATP2A; P-type Ca2+ transporter type 2A [EC:7.2.2.10]; K05853	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [Source:HGNC Symbol%3BAcc:HGNC:811]
ENSG00000039560	63.43	58.50	59.43	65.36	56.99	64.80	-0.0332443718975187	7.53856491112541	0.634898091658087	0.891510136177514	5:34656236-34832627:+	RAI14	9;GO:0001650,cellular_component fibrillar center;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0097190,biological_process apoptotic signaling pathway;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling	NA	retinoic acid induced 14 [Source:HGNC Symbol%3BAcc:HGNC:14873]
ENSG00000188368	1.41	1.91	0.96	1.04	2.24	1.52	-0.180299301985114	0.907688244699733	0.635011629276894	0.891510136177514	19:42302097-42310821:+	PRR19	1;GO:0005515,molecular_function protein binding	NA	proline rich 19 [Source:HGNC Symbol%3BAcc:HGNC:33728]
ENSG00000161664	3.38	3.94	3.30	3.25	3.24	3.57	0.0760746774928937	2.26810944431044	0.635034892447486	0.891510136177514	17:44170446-44179083:+	ASB16	10;GO:0000151,cellular_component ubiquitin ligase complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	ankyrin repeat and SOCS box containing 16 [Source:HGNC Symbol%3BAcc:HGNC:19768]
ENSG00000114209	114.13	122.62	119.49	123.81	119.70	123.16	-0.0316476071929691	6.32519663445535	0.635059666603176	0.891510136177514	3:167683297-167734939:-	PDCD10	33;GO:0000139,cellular_component Golgi membrane;GO:0001525,biological_process angiogenesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030335,biological_process positive regulation of cell migration;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0036481,biological_process intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0042542,biological_process response to hydrogen peroxide;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0044319,biological_process wound healing, spreading of cells;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0047485,molecular_function protein N-terminus binding;GO:0050821,biological_process protein stabilization;GO:0051683,biological_process establishment of Golgi localization;GO:0070062,cellular_component extracellular exosome;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:0090168,biological_process Golgi reassembly;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:1903588,biological_process negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	programmed cell death 10 [Source:HGNC Symbol%3BAcc:HGNC:8761]
ENSG00000242110	121.97	151.35	127.20	115.33	153.33	121.26	0.0498430416075459	7.69416073045585	0.635136699880373	0.891510136177514	5:33986177-34008108:-	AMACR	14;GO:0003824,molecular_function catalytic activity;GO:0005102,molecular_function receptor binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0005886,cellular_component plasma membrane;GO:0006631,biological_process fatty acid metabolic process;GO:0006699,biological_process bile acid biosynthetic process;GO:0008111,molecular_function alpha-methylacyl-CoA racemase activity;GO:0008206,biological_process bile acid metabolic process;GO:0016853,molecular_function isomerase activity;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0043231,cellular_component intracellular membrane-bounded organelle	E5.1.99.4, AMACR, mcr; alpha-methylacyl-CoA racemase [EC:5.1.99.4]; K01796	alpha-methylacyl-CoA racemase [Source:HGNC Symbol%3BAcc:HGNC:451]
ENSG00000157617	4.80	4.81	5.78	5.38	5.59	5.22	-0.0564939940415297	3.48115813995156	0.635182119097231	0.891510136177514	21:41885111-41953890:-	C2CD2	4;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	C2 calcium dependent domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:1266]
ENSG00000068305	21.15	22.14	22.40	21.79	22.71	23.31	-0.0358383139499325	5.20755983390917	0.635557288705632	0.891767914235252	15:99565416-99716466:+	MEF2A	46;GO:0000002,biological_process mitochondrial genome maintenance;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007507,biological_process heart development;GO:0007517,biological_process muscle organ development;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0019901,molecular_function protein kinase binding;GO:0030154,biological_process cell differentiation;GO:0033613,molecular_function activating transcription factor binding;GO:0035035,molecular_function histone acetyltransferase binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048311,biological_process mitochondrion distribution;GO:0048813,biological_process dendrite morphogenesis;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0055005,biological_process ventricular cardiac myofibril assembly;GO:0061337,biological_process cardiac conduction;GO:0070375,biological_process ERK5 cascade;GO:0071277,biological_process cellular response to calcium ion	MEF2A; MADS-box transcription enhancer factor 2A; K09260	myocyte enhancer factor 2A [Source:HGNC Symbol%3BAcc:HGNC:6993]
ENSG00000165269	0.82	0.89	1.66	1.40	1.24	1.20	-0.156874317373842	0.773606443008127	0.635695450855782	0.891767914235252	9:33383178-33402682:-	AQP7	14;GO:0005215,molecular_function transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006810,biological_process transport;GO:0006833,biological_process water transport;GO:0007588,biological_process excretion;GO:0015250,molecular_function water channel activity;GO:0015254,molecular_function glycerol channel activity;GO:0015793,biological_process glycerol transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	AQP7; aquaporin-7; K08771	aquaporin 7 [Source:HGNC Symbol%3BAcc:HGNC:640]
ENSG00000023572	24.73	18.68	19.06	25.00	18.28	22.90	-0.0657814756166006	3.74248792243302	0.63573904649709	0.891767914235252	1:193096467-193106114:-	GLRX2	29;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006749,biological_process glutathione metabolic process;GO:0006915,biological_process apoptotic process;GO:0007568,biological_process aging;GO:0008794,molecular_function arsenate reductase (glutaredoxin) activity;GO:0009055,molecular_function electron carrier activity;GO:0009266,biological_process response to temperature stimulus;GO:0009966,biological_process regulation of signal transduction;GO:0010033,biological_process response to organic substance;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015038,molecular_function glutathione disulfide oxidoreductase activity;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0042262,biological_process DNA protection;GO:0042542,biological_process response to hydrogen peroxide;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045454,biological_process cell redox homeostasis;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0051775,biological_process response to redox state;GO:0055114,biological_process oxidation-reduction process;GO:0071451,biological_process cellular response to superoxide	NA	glutaredoxin 2 [Source:HGNC Symbol%3BAcc:HGNC:16065]
ENSG00000046651	16.24	17.36	17.80	18.75	16.37	17.98	-0.0363992087338713	5.73096227712573	0.635757641807779	0.891767914235252	X:13734744-13769353:+	OFD1	22;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0034451,cellular_component centriolar satellite;GO:0036064,cellular_component ciliary basal body;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043014,molecular_function alpha-tubulin binding;GO:0043015,molecular_function gamma-tubulin binding;GO:0060271,biological_process cilium morphogenesis;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	OFD1%2C centriole and centriolar satellite protein [Source:HGNC Symbol%3BAcc:HGNC:2567]
ENSG00000133315	20.06	23.62	22.57	22.50	22.01	24.23	-0.0485990854004002	4.46432324604493	0.635919866329619	0.891767914235252	11:63998557-64166106:-	MACROD1	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019213,molecular_function deacetylase activity;GO:0042278,biological_process purine nucleoside metabolic process;GO:0051725,biological_process protein de-ADP-ribosylation	NA	MACRO domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29598]
ENSG00000198805	69.35	70.79	65.32	67.57	74.93	69.33	-0.0335055599924472	6.11620792540857	0.635951907898428	0.891767914235252	14:20468953-20477094:+	PNP	33;GO:0001882,molecular_function nucleoside binding;GO:0002060,molecular_function purine nucleobase binding;GO:0003824,molecular_function catalytic activity;GO:0004731,molecular_function purine-nucleoside phosphorylase activity;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006148,biological_process inosine catabolic process;GO:0006195,biological_process purine nucleotide catabolic process;GO:0006738,biological_process nicotinamide riboside catabolic process;GO:0006955,biological_process immune response;GO:0008144,molecular_function drug binding;GO:0009116,biological_process nucleoside metabolic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016763,molecular_function transferase activity, transferring pentosyl groups;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0034418,biological_process urate biosynthetic process;GO:0034774,cellular_component secretory granule lumen;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042278,biological_process purine nucleoside metabolic process;GO:0042301,molecular_function phosphate ion binding;GO:0042493,biological_process response to drug;GO:0043101,biological_process purine-containing compound salvage;GO:0043312,biological_process neutrophil degranulation;GO:0046638,biological_process positive regulation of alpha-beta T cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0070970,biological_process interleukin-2 secretion;GO:1904813,cellular_component ficolin-1-rich granule lumen	punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1]; K03783	purine nucleoside phosphorylase [Source:HGNC Symbol%3BAcc:HGNC:7892]
ENSG00000179588	1.33	1.03	1.15	1.07	1.28	0.99	0.100099929841906	1.90625860937581	0.635969640941465	0.891767914235252	16:88453316-88537016:+	ZFPM1	46;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0002295,biological_process T-helper cell lineage commitment;GO:0003151,biological_process outflow tract morphogenesis;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003192,biological_process mitral valve formation;GO:0003195,biological_process tricuspid valve formation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007507,biological_process heart development;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0010724,biological_process regulation of definitive erythrocyte differentiation;GO:0017053,cellular_component transcriptional repressor complex;GO:0030218,biological_process erythrocyte differentiation;GO:0030219,biological_process megakaryocyte differentiation;GO:0030220,biological_process platelet formation;GO:0030851,biological_process granulocyte differentiation;GO:0032091,biological_process negative regulation of protein binding;GO:0032642,biological_process regulation of chemokine production;GO:0035162,biological_process embryonic hemopoiesis;GO:0035855,biological_process megakaryocyte development;GO:0045078,biological_process positive regulation of interferon-gamma biosynthetic process;GO:0045403,biological_process negative regulation of interleukin-4 biosynthetic process;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048872,biological_process homeostasis of number of cells;GO:0055008,biological_process cardiac muscle tissue morphogenesis;GO:0060318,biological_process definitive erythrocyte differentiation;GO:0060319,biological_process primitive erythrocyte differentiation;GO:0060377,biological_process negative regulation of mast cell differentiation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060413,biological_process atrial septum morphogenesis;GO:0071733,biological_process transcriptional activation by promoter-enhancer looping	NA	zinc finger protein%2C FOG family member 1 [Source:HGNC Symbol%3BAcc:HGNC:19762]
ENSG00000167447	8.96	9.43	8.08	8.80	8.25	8.83	0.0395226452954481	4.70694256103084	0.635993655942044	0.891767914235252	17:59209399-59215247:+	SMG8	5;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0045859,biological_process regulation of protein kinase activity	NA	SMG8%2C nonsense mediated mRNA decay factor [Source:HGNC Symbol%3BAcc:HGNC:25551]
ENSG00000243279	5.84	3.56	5.49	3.64	4.55	5.70	0.131620707092526	1.65523229241115	0.636023999118278	0.891767914235252	X:49071155-49074071:-	PRAF2	7;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0015813,biological_process L-glutamate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	PRA1 domain family member 2 [Source:HGNC Symbol%3BAcc:HGNC:28911]
ENSG00000169727	32.91	36.12	33.78	32.44	36.22	32.44	0.0336946165213466	5.86985790472679	0.636099064282482	0.891767914235252	17:82050690-82057470:+	GPS1	15;GO:0000188,biological_process inactivation of MAPK activity;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0007049,biological_process cell cycle;GO:0007254,biological_process JNK cascade;GO:0008180,cellular_component COP9 signalosome;GO:0034260,biological_process negative regulation of GTPase activity;GO:0043687,biological_process post-translational protein modification	NA	G protein pathway suppressor 1 [Source:HGNC Symbol%3BAcc:HGNC:4549]
ENSG00000136888	205.89	201.93	202.09	223.35	207.17	198.44	-0.0320020548044289	6.19569975191646	0.636200603785717	0.891767914235252	9:114587745-114598373:+	ATP6V1G1	23;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008553,molecular_function hydrogen-exporting ATPase activity, phosphorylative mechanism;GO:0015992,biological_process proton transport;GO:0016241,biological_process regulation of macroautophagy;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0016820,molecular_function hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;GO:0016887,molecular_function ATPase activity;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0036295,biological_process cellular response to increased oxygen levels;GO:0051117,molecular_function ATPase binding;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification;GO:1902600,biological_process hydrogen ion transmembrane transport	ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G; K02152	ATPase H+ transporting V1 subunit G1 [Source:HGNC Symbol%3BAcc:HGNC:864]
ENSG00000137815	25.94	25.33	25.42	24.51	25.60	25.59	0.0310163936905856	5.77864882445864	0.636227877907628	0.891767914235252	15:41408407-41483563:+	RTF1	25;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001711,biological_process endodermal cell fate commitment;GO:0001832,biological_process blastocyst growth;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016570,biological_process histone modification;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0019827,biological_process stem cell population maintenance;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0080182,biological_process histone H3-K4 trimethylation;GO:1990269,molecular_function RNA polymerase II C-terminal domain phosphoserine binding	NA	RTF1 homolog%2C Paf1/RNA polymerase II complex component [Source:HGNC Symbol%3BAcc:HGNC:28996]
ENSG00000176428	3.10	3.05	4.11	3.88	2.12	3.46	0.132488964896993	1.39723374917925	0.636375527228183	0.891874158234553	7:73667824-73672112:+	VPS37D	15;GO:0000813,cellular_component ESCRT I complex;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0043657,cellular_component host cell;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus	VPS37; ESCRT-I complex subunit VPS37; K12185	VPS37D%2C ESCRT-I subunit [Source:HGNC Symbol%3BAcc:HGNC:18287]
ENSG00000068724	10.08	9.50	10.53	9.96	9.31	10.28	0.0407616298359711	4.81849781070134	0.636493998613464	0.891939490267434	2:46916156-47076137:+	TTC7A	6;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006879,biological_process cellular iron ion homeostasis;GO:0016020,cellular_component membrane;GO:0030097,biological_process hemopoiesis;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	tetratricopeptide repeat domain 7A [Source:HGNC Symbol%3BAcc:HGNC:19750]
ENSG00000151657	25.99	22.80	21.05	24.77	25.47	22.49	-0.0438620020220046	4.82126548573109	0.636886623302983	0.892107633811215	10:7750961-7787981:-	KIN	19;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006397,biological_process mRNA processing;GO:0006479,biological_process protein methylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016032,biological_process viral process;GO:0016363,cellular_component nuclear matrix;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding	NA	Kin17 DNA and RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:6327]
ENSG00000181544	2.06	1.45	1.51	1.45	2.44	1.61	-0.109907062016075	2.2314126729913	0.636919431351387	0.892107633811215	X:14843406-14873069:-	FANCB	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex	FANCB; fanconi anemia group B protein; K10889	Fanconi anemia complementation group B [Source:HGNC Symbol%3BAcc:HGNC:3583]
ENSG00000156958	14.28	13.83	14.63	14.28	13.46	14.22	0.0402410326064921	4.62964770637802	0.636929041864403	0.892107633811215	15:49155655-49367869:+	GALK2	14;GO:0000166,molecular_function nucleotide binding;GO:0004335,molecular_function galactokinase activity;GO:0005524,molecular_function ATP binding;GO:0005534,molecular_function galactose binding;GO:0005737,cellular_component cytoplasm;GO:0005975,biological_process carbohydrate metabolic process;GO:0006012,biological_process galactose metabolic process;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0033858,molecular_function N-acetylgalactosamine kinase activity;GO:0046835,biological_process carbohydrate phosphorylation	galK; galactokinase [EC:2.7.1.6]; K00849	galactokinase 2 [Source:HGNC Symbol%3BAcc:HGNC:4119]
ENSG00000151503	11.79	12.68	10.74	12.03	12.95	11.42	-0.0389615827045172	5.80672447319882	0.637199114083654	0.892107633811215	11:134150118-134225454:-	NCAPD3	15;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000799,cellular_component nuclear condensin complex;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0010032,biological_process meiotic chromosome condensation;GO:0016020,cellular_component membrane;GO:0030261,biological_process chromosome condensation;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0035064,molecular_function methylated histone binding;GO:0051301,biological_process cell division;GO:0051304,biological_process chromosome separation	NA	non-SMC condensin II complex subunit D3 [Source:HGNC Symbol%3BAcc:HGNC:28952]
ENSG00000151131	6.57	6.21	8.91	8.85	7.73	6.86	-0.0873034745993348	2.39691995114117	0.637220708801872	0.892107633811215	12:104986309-105074197:+	C12orf45	NA	NA	chromosome 12 open reading frame 45 [Source:HGNC Symbol%3BAcc:HGNC:28628]
ENSG00000037965	5.06	4.08	3.04	5.98	3.55	3.87	-0.123127290614036	1.7026062643687	0.637239153461964	0.892107633811215	12:54009105-54012362:+	HOXC8	13;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030182,biological_process neuron differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048705,biological_process skeletal system morphogenesis	NA	homeobox C8 [Source:HGNC Symbol%3BAcc:HGNC:5129]
ENSG00000203666	4.00	4.11	4.03	3.59	3.78	4.12	0.087147884144819	2.06369204235693	0.637307804208242	0.892107633811215	1:244969704-245127164:+	EFCAB2	1;GO:0005509,molecular_function calcium ion binding	NA	EF-hand calcium binding domain 2 [Source:HGNC Symbol%3BAcc:HGNC:28166]
ENSG00000106799	8.92	8.29	8.66	8.32	8.53	8.37	0.0530124100978946	3.71361890152656	0.637317249719743	0.892107633811215	9:99104037-99154192:+	TGFBR1	112;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001501,biological_process skeletal system development;GO:0001525,biological_process angiogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0001824,biological_process blastocyst development;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002088,biological_process lens development in camera-type eye;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003223,biological_process ventricular compact myocardium morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005024,molecular_function transforming growth factor beta-activated receptor activity;GO:0005025,molecular_function transforming growth factor beta receptor activity, type I;GO:0005057,molecular_function receptor signaling protein activity;GO:0005102,molecular_function receptor binding;GO:0005114,molecular_function type II transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005623,cellular_component cell;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007507,biological_process heart development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008354,biological_process germ cell migration;GO:0008584,biological_process male gonad development;GO:0009791,biological_process post-embryonic development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009986,cellular_component cell surface;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019838,molecular_function growth factor binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030199,biological_process collagen fibril organization;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031396,biological_process regulation of protein ubiquitination;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0032924,biological_process activin receptor signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0042060,biological_process wound healing;GO:0042118,biological_process endothelial cell activation;GO:0043062,biological_process extracellular structure organization;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043235,cellular_component receptor complex;GO:0043393,biological_process regulation of protein binding;GO:0043542,biological_process endothelial cell migration;GO:0045121,cellular_component membrane raft;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0048538,biological_process thymus development;GO:0048663,biological_process neuron fate commitment;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0048762,biological_process mesenchymal cell differentiation;GO:0048844,biological_process artery morphogenesis;GO:0048870,biological_process cell motility;GO:0050431,molecular_function transforming growth factor beta binding;GO:0051272,biological_process positive regulation of cellular component movement;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060017,biological_process parathyroid gland development;GO:0060021,biological_process palate development;GO:0060037,biological_process pharyngeal system development;GO:0060043,biological_process regulation of cardiac muscle cell proliferation;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060978,biological_process angiogenesis involved in coronary vascular morphogenesis;GO:0060982,biological_process coronary artery morphogenesis;GO:0070022,cellular_component transforming growth factor beta receptor homodimeric complex;GO:0070411,molecular_function I-SMAD binding;GO:0070723,biological_process response to cholesterol;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1905007,biological_process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:1905075,biological_process positive regulation of occluding junction disassembly;GO:1905223,biological_process epicardium morphogenesis;GO:2001235,biological_process positive regulation of apoptotic signaling pathway;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]; K04674	transforming growth factor beta receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:11772]
ENSG00000081721	26.07	23.31	24.01	27.15	23.67	25.43	-0.0400020009990656	4.74917768872777	0.637412232828123	0.892107633811215	1:161749757-161757238:+	DUSP12	18;GO:0003676,molecular_function nucleic acid binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008270,molecular_function zinc ion binding;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019900,molecular_function kinase binding;GO:0033133,biological_process positive regulation of glucokinase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0046872,molecular_function metal ion binding	NA	dual specificity phosphatase 12 [Source:HGNC Symbol%3BAcc:HGNC:3067]
ENSG00000067082	66.73	62.93	65.92	63.67	65.91	63.60	0.0315412050680038	6.04542478653782	0.637449121218513	0.892107633811215	10:3775995-3785281:-	KLF6	17;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030183,biological_process B cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	Kruppel like factor 6 [Source:HGNC Symbol%3BAcc:HGNC:2235]
ENSG00000138443	29.53	27.85	31.63	32.67	28.69	30.68	-0.0341456606365207	5.9067714460537	0.637485431763482	0.892107633811215	2:203328218-203447723:+	ABI2	26;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006928,biological_process movement of cell or subcellular component;GO:0007010,biological_process cytoskeleton organization;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008154,biological_process actin polymerization or depolymerization;GO:0016032,biological_process viral process;GO:0016477,biological_process cell migration;GO:0016601,biological_process Rac protein signal transduction;GO:0017124,molecular_function SH3 domain binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019900,molecular_function kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0030296,molecular_function protein tyrosine kinase activator activity;GO:0031209,cellular_component SCAR complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0042995,cellular_component cell projection;GO:0048365,molecular_function Rac GTPase binding;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070064,molecular_function proline-rich region binding;GO:2000601,biological_process positive regulation of Arp2/3 complex-mediated actin nucleation	ABI2; abl interactor 2; K05751	abl interactor 2 [Source:HGNC Symbol%3BAcc:HGNC:24011]
ENSG00000132510	9.38	8.88	9.82	9.70	9.38	9.91	-0.0319097901070497	5.59158403445767	0.637518159725747	0.892107633811215	17:7839903-7854796:+	KDM6B	27;GO:0002437,biological_process inflammatory response to antigenic stimulus;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006954,biological_process inflammatory response;GO:0008013,molecular_function beta-catenin binding;GO:0010468,biological_process regulation of gene expression;GO:0014823,biological_process response to activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016577,biological_process histone demethylation;GO:0021766,biological_process hippocampus development;GO:0032452,molecular_function histone demethylase activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045165,biological_process cell fate commitment;GO:0045446,biological_process endothelial cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048333,biological_process mesodermal cell differentiation;GO:0051213,molecular_function dioxygenase activity;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055114,biological_process oxidation-reduction process;GO:0060992,biological_process response to fungicide;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071557,biological_process histone H3-K27 demethylation;GO:0071558,molecular_function histone demethylase activity (H3-K27 specific)	NA	lysine demethylase 6B [Source:HGNC Symbol%3BAcc:HGNC:29012]
ENSG00000163482	11.57	12.18	12.17	10.72	12.48	12.10	0.0351135862152004	5.56920005485501	0.637548281603101	0.892107633811215	2:218672025-218702716:+	STK36	24;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003351,biological_process epithelial cilium movement;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007228,biological_process positive regulation of hh target transcription factor activity;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0008134,molecular_function transcription factor binding;GO:0009791,biological_process post-embryonic development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030030,biological_process cell projection organization;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0060271,biological_process cilium morphogenesis	FU; fused [EC:2.7.11.1]; K06228	serine/threonine kinase 36 [Source:HGNC Symbol%3BAcc:HGNC:17209]
ENSG00000066926	20.00	20.82	17.17	19.23	20.03	20.89	-0.0460792332035469	4.75373049731267	0.637812358368296	0.8923765559542	18:57548282-57586772:-	FECH	25;GO:0004325,molecular_function ferrochelatase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0008198,molecular_function ferrous iron binding;GO:0009416,biological_process response to light stimulus;GO:0010038,biological_process response to metal ion;GO:0010288,biological_process response to lead ion;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0017085,biological_process response to insecticide;GO:0042493,biological_process response to drug;GO:0045471,biological_process response to ethanol;GO:0046501,biological_process protoporphyrinogen IX metabolic process;GO:0046685,biological_process response to arsenic-containing substance;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0051597,biological_process response to methylmercury;GO:0070541,biological_process response to platinum ion;GO:0071549,biological_process cellular response to dexamethasone stimulus	hemH, FECH; protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1 4.99.1.9]; K01772	ferrochelatase [Source:HGNC Symbol%3BAcc:HGNC:3647]
ENSG00000140265	9.27	7.20	7.93	8.33	8.06	9.14	-0.0465638266566867	4.43007062216795	0.637984785594344	0.892517203153679	15:43358171-43371025:-	ZSCAN29	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 29 [Source:HGNC Symbol%3BAcc:HGNC:26673]
ENSG00000116704	5.44	5.38	4.98	5.69	4.70	4.69	0.0779208488775466	2.49222931878758	0.638067442496178	0.892532247431266	1:66999331-67054099:-	SLC35D1	11;GO:0005461,molecular_function UDP-glucuronic acid transmembrane transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006065,biological_process UDP-glucuronate biosynthetic process;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015165,molecular_function pyrimidine nucleotide-sugar transmembrane transporter activity;GO:0015787,biological_process UDP-glucuronic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0090481,biological_process pyrimidine nucleotide-sugar transmembrane transport	NA	solute carrier family 35 member D1 [Source:HGNC Symbol%3BAcc:HGNC:20800]
ENSG00000118420	5.71	4.65	4.55	5.43	5.44	4.99	-0.0680545221428814	2.67645857567969	0.638316384917273	0.892779863208801	6:82892397-83065841:-	UBE3D	10;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0005737,cellular_component cytoplasm;GO:0006513,biological_process protein monoubiquitination;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030332,molecular_function cyclin binding;GO:0044390,molecular_function ubiquitin-like protein conjugating enzyme binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ubiquitin protein ligase E3D [Source:HGNC Symbol%3BAcc:HGNC:21381]
ENSG00000221983	609.29	591.56	614.51	645.10	594.12	627.59	-0.0283640526042735	8.39269529635714	0.63846041444451	0.89285096685842	19:18571729-18577550:+	UBA52	106;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000187,biological_process activation of MAPK activity;GO:0000209,biological_process protein polyubiquitination;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0005978,biological_process glycogen biosynthetic process;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006457,biological_process protein folding;GO:0006464,biological_process cellular protein modification process;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007219,biological_process Notch signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016055,biological_process Wnt signaling pathway;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019058,biological_process viral life cycle;GO:0019068,biological_process virion assembly;GO:0019083,biological_process viral transcription;GO:0019985,biological_process translesion synthesis;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031982,cellular_component vesicle;GO:0032479,biological_process regulation of type I interferon production;GO:0032480,biological_process negative regulation of type I interferon production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034220,biological_process ion transmembrane transport;GO:0035635,biological_process entry of bacterium into host cell;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0036297,biological_process interstrand cross-link repair;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043657,cellular_component host cell;GO:0044267,biological_process cellular protein metabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0045087,biological_process innate immune response;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060544,biological_process regulation of necroptotic process;GO:0061024,biological_process membrane organization;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070987,biological_process error-free translesion synthesis;GO:0075733,biological_process intracellular transport of virus;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904380,biological_process endoplasmic reticulum mannose trimming	RP-L40e, RPL40; large subunit ribosomal protein L40e; K02927	ubiquitin A-52 residue ribosomal protein fusion product 1 [Source:HGNC Symbol%3BAcc:HGNC:12458]
ENSG00000245680	0.44	0.71	0.63	0.79	0.32	0.47	0.163401773178881	0.652358561303395	0.638547725805971	0.89285096685842	19:37181578-37218153:-	ZNF585B	7;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 585B [Source:HGNC Symbol%3BAcc:HGNC:30948]
ENSG00000159256	12.81	11.01	13.18	12.45	10.99	12.85	0.0440078066110696	5.20255954812686	0.638583008440269	0.89285096685842	21:36320188-36386148:+	MORC3	15;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007569,biological_process cell aging;GO:0008270,molecular_function zinc ion binding;GO:0009791,biological_process post-embryonic development;GO:0016032,biological_process viral process;GO:0016363,cellular_component nuclear matrix;GO:0016605,cellular_component PML body;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0050821,biological_process protein stabilization;GO:0051457,biological_process maintenance of protein location in nucleus	NA	MORC family CW-type zinc finger 3 [Source:HGNC Symbol%3BAcc:HGNC:23572]
ENSG00000018625	0.55	0.41	0.63	0.56	0.69	0.53	-0.1316086094025	0.91572514381977	0.638745064931282	0.892976967112514	1:160115758-160143591:+	ATP1A2	72;GO:0000166,molecular_function nucleotide binding;GO:0001504,biological_process neurotransmitter uptake;GO:0002026,biological_process regulation of the force of heart contraction;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0005391,molecular_function sodium:potassium-exchanging ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005890,cellular_component sodium:potassium-exchanging ATPase complex;GO:0005901,cellular_component caveola;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006883,biological_process cellular sodium ion homeostasis;GO:0006937,biological_process regulation of muscle contraction;GO:0006940,biological_process regulation of smooth muscle contraction;GO:0006942,biological_process regulation of striated muscle contraction;GO:0008144,molecular_function drug binding;GO:0008217,biological_process regulation of blood pressure;GO:0008344,biological_process adult locomotory behavior;GO:0008542,biological_process visual learning;GO:0010107,biological_process potassium ion import;GO:0010248,biological_process establishment or maintenance of transmembrane electrochemical gradient;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014704,cellular_component intercalated disc;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0019229,biological_process regulation of vasoconstriction;GO:0019829,molecular_function cation-transporting ATPase activity;GO:0030007,biological_process cellular potassium ion homeostasis;GO:0030315,cellular_component T-tubule;GO:0030955,molecular_function potassium ion binding;GO:0031402,molecular_function sodium ion binding;GO:0034220,biological_process ion transmembrane transport;GO:0035094,biological_process response to nicotine;GO:0036376,biological_process sodium ion export from cell;GO:0040011,biological_process locomotion;GO:0042383,cellular_component sarcolemma;GO:0043005,cellular_component neuron projection;GO:0043197,cellular_component dendritic spine;GO:0043209,cellular_component myelin sheath;GO:0045202,cellular_component synapse;GO:0045822,biological_process negative regulation of heart contraction;GO:0045988,biological_process negative regulation of striated muscle contraction;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0051481,biological_process negative regulation of cytosolic calcium ion concentration;GO:0051946,biological_process regulation of glutamate uptake involved in transmission of nerve impulse;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060048,biological_process cardiac muscle contraction;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:0086009,biological_process membrane repolarization;GO:0086012,biological_process membrane depolarization during cardiac muscle cell action potential;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0090662,biological_process ATP hydrolysis coupled transmembrane transport;GO:1903170,biological_process negative regulation of calcium ion transmembrane transport;GO:1903280,biological_process negative regulation of calcium:sodium antiporter activity;GO:1903416,biological_process response to glycoside;GO:1903561,cellular_component extracellular vesicle;GO:1903779,biological_process regulation of cardiac conduction;GO:1990239,molecular_function steroid hormone binding;GO:1990573,biological_process potassium ion import across plasma membrane	ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]; K01539	ATPase Na+/K+ transporting subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:800]
ENSG00000170425	9.57	7.39	8.79	9.10	6.09	9.39	0.0853150757692537	3.09761423534669	0.63881896569213	0.892979709587433	17:15944916-15975746:+	ADORA2B	28;GO:0000187,biological_process activation of MAPK activity;GO:0001609,molecular_function G-protein coupled adenosine receptor activity;GO:0001973,biological_process adenosine receptor signaling pathway;GO:0002882,biological_process positive regulation of chronic inflammatory response to non-antigenic stimulus;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006968,biological_process cellular defense response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007254,biological_process JNK cascade;GO:0007588,biological_process excretion;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0030828,biological_process positive regulation of cGMP biosynthetic process;GO:0031284,biological_process positive regulation of guanylate cyclase activity;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032722,biological_process positive regulation of chemokine production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0043306,biological_process positive regulation of mast cell degranulation;GO:0044267,biological_process cellular protein metabolic process;GO:0060087,biological_process relaxation of vascular smooth muscle	ADORA2B; adenosine receptor A2b; K04267	adenosine A2b receptor [Source:HGNC Symbol%3BAcc:HGNC:264]
ENSG00000196267	2.88	2.56	3.42	3.18	2.47	2.87	0.0781434328921893	3.12416359591017	0.638954955837004	0.892999845532983	19:52153863-52171643:-	ZNF836	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 836 [Source:HGNC Symbol%3BAcc:HGNC:34333]
ENSG00000115541	118.51	145.93	96.67	110.07	126.19	113.39	0.0534186231288114	5.37824450841587	0.638977251915247	0.892999845532983	2:197499993-197503457:+	HSPE1	16;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006457,biological_process protein folding;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0046872,molecular_function metal ion binding;GO:0051082,molecular_function unfolded protein binding;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051087,molecular_function chaperone binding;GO:0070062,cellular_component extracellular exosome	NA	heat shock protein family E (Hsp10) member 1 [Source:HGNC Symbol%3BAcc:HGNC:5269]
ENSG00000123191	1.68	1.73	1.68	1.83	1.92	1.62	-0.0664217512293361	2.97390965292451	0.639499601345321	0.893534436965571	13:51930435-52012125:-	ATP7B	40;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0004008,molecular_function copper-exporting ATPase activity;GO:0005375,molecular_function copper ion transmembrane transporter activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006825,biological_process copper ion transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0007595,biological_process lactation;GO:0015677,biological_process copper ion import;GO:0015680,biological_process intracellular copper ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0019829,molecular_function cation-transporting ATPase activity;GO:0030001,biological_process metal ion transport;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0034220,biological_process ion transmembrane transport;GO:0035434,biological_process copper ion transmembrane transport;GO:0043682,molecular_function copper-transporting ATPase activity;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051208,biological_process sequestering of calcium ion;GO:0060003,biological_process copper ion export;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	NA	ATPase copper transporting beta [Source:HGNC Symbol%3BAcc:HGNC:870]
ENSG00000214736	272.64	306.93	302.03	290.72	300.64	276.20	0.0330385264599058	6.01915782552785	0.639539658467487	0.893534436965571	6:41787661-41789898:+	TOMM6	7;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy	NA	translocase of outer mitochondrial membrane 6 [Source:HGNC Symbol%3BAcc:HGNC:34528]
ENSG00000132763	4.34	7.23	4.18	3.72	6.01	4.82	0.104808601658596	2.12284033081332	0.639575724840014	0.893534436965571	1:45500052-45513382:+	MMACHC	16;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0009235,biological_process cobalamin metabolic process;GO:0009236,biological_process cobalamin biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0031419,molecular_function cobalamin binding;GO:0032451,molecular_function demethylase activity;GO:0033787,molecular_function cyanocobalamin reductase (cyanide-eliminating) activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043295,molecular_function glutathione binding;GO:0055114,biological_process oxidation-reduction process;GO:0070988,biological_process demethylation;GO:0071949,molecular_function FAD binding	MMACHC; cyanocobalamin reductase (cyanide-eliminating) / alkylcobalamin dealkylase [EC:1.16.1.6 2.5.1.151]; K14618	methylmalonic aciduria (cobalamin deficiency) cblC type%2C with homocystinuria [Source:HGNC Symbol%3BAcc:HGNC:24525]
ENSG00000112139	0.47	0.92	0.69	0.80	0.98	0.51	-0.154578666417845	1.20701958816794	0.639706229688163	0.893558257602843	6:37630678-37699306:-	MDGA1	14;GO:0001764,biological_process neuron migration;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0016020,cellular_component membrane;GO:0021527,biological_process spinal cord association neuron differentiation;GO:0030154,biological_process cell differentiation;GO:0031225,cellular_component anchored component of membrane;GO:0046658,cellular_component anchored component of plasma membrane	NA	MAM domain containing glycosylphosphatidylinositol anchor 1 [Source:HGNC Symbol%3BAcc:HGNC:19267]
ENSG00000182973	16.88	16.04	16.36	18.13	14.67	18.32	-0.0412270603817268	5.39530478658324	0.639736746581524	0.893558257602843	3:32685144-32773875:+	CNOT10	12;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0016020,cellular_component membrane;GO:0030014,cellular_component CCR4-NOT complex;GO:0031047,biological_process gene silencing by RNA	CNOT10; CCR4-NOT transcription complex subunit 10; K12607	CCR4-NOT transcription complex subunit 10 [Source:HGNC Symbol%3BAcc:HGNC:23817]
ENSG00000130165	33.46	29.79	35.44	34.20	35.11	33.53	-0.0401296446113133	4.45811186114411	0.639902499205978	0.893565906511487	19:11551146-11559236:-	ELOF1	11;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006414,biological_process translational elongation;GO:0008023,cellular_component transcription elongation factor complex;GO:0046872,molecular_function metal ion binding;GO:0048096,biological_process chromatin-mediated maintenance of transcription	NA	elongation factor 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:28691]
ENSG00000136827	28.51	33.97	39.02	33.38	37.69	34.81	-0.0499781249468663	5.11196915096694	0.639926133295942	0.893565906511487	9:129812943-129824134:-	TOR1A	50;GO:0000166,molecular_function nucleotide binding;GO:0000338,biological_process protein deneddylation;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006979,biological_process response to oxidative stress;GO:0006996,biological_process organelle organization;GO:0006998,biological_process nuclear envelope organization;GO:0007155,biological_process cell adhesion;GO:0008021,cellular_component synaptic vesicle;GO:0008092,molecular_function cytoskeletal protein binding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0019894,molecular_function kinesin binding;GO:0030054,cellular_component cell junction;GO:0030133,cellular_component transport vesicle;GO:0030141,cellular_component secretory granule;GO:0030426,cellular_component growth cone;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031175,biological_process neuron projection development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031965,cellular_component nuclear membrane;GO:0034504,biological_process protein localization to nucleus;GO:0042406,cellular_component extrinsic component of endoplasmic reticulum membrane;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044319,biological_process wound healing, spreading of cells;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0045202,cellular_component synapse;GO:0048489,biological_process synaptic vesicle transport;GO:0051082,molecular_function unfolded protein binding;GO:0051085,biological_process chaperone mediated protein folding requiring cofactor;GO:0051260,biological_process protein homooligomerization;GO:0051584,biological_process regulation of dopamine uptake involved in synaptic transmission;GO:0051787,molecular_function misfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:0071763,biological_process nuclear membrane organization;GO:0072321,biological_process chaperone-mediated protein transport;GO:1900244,biological_process positive regulation of synaptic vesicle endocytosis;GO:2000008,biological_process regulation of protein localization to cell surface	NA	torsin family 1 member A [Source:HGNC Symbol%3BAcc:HGNC:3098]
ENSG00000257591	3.76	5.78	4.87	4.89	5.08	5.27	-0.0888990584962882	2.64185889419202	0.640023867083347	0.893565906511487	19:12142089-12156729:-	ZNF625	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 625 [Source:HGNC Symbol%3BAcc:HGNC:30571]
ENSG00000007376	8.23	8.93	7.51	8.21	8.25	7.29	0.0597801907155463	3.25380019586169	0.640030167952439	0.893565906511487	16:784973-788397:-	RPUSD1	10;GO:0000455,biological_process enzyme-directed rRNA pseudouridine synthesis;GO:0001522,biological_process pseudouridine synthesis;GO:0003674,molecular_function molecular_function;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0019239,molecular_function deaminase activity;GO:0031119,biological_process tRNA pseudouridine synthesis	NA	RNA pseudouridylate synthase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14173]
ENSG00000127081	3.70	3.23	3.23	3.75	2.94	3.08	0.0719362015807755	3.12520697893817	0.64028898350263	0.893727023249349	9:92845030-92878038:-	ZNF484	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 484 [Source:HGNC Symbol%3BAcc:HGNC:23385]
ENSG00000169972	9.71	11.67	9.15	9.88	9.93	9.51	0.0570678147416352	3.19772305385748	0.640289568819501	0.893727023249349	1:1308566-1311677:+	PUSL1	8;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity;GO:0031119,biological_process tRNA pseudouridine synthesis;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	pseudouridylate synthase-like 1 [Source:HGNC Symbol%3BAcc:HGNC:26914]
ENSG00000120925	10.40	8.89	11.29	9.57	11.17	11.65	-0.0622044252740611	3.38816734871104	0.640382939852669	0.893756850954708	8:42849636-42897290:-	RNF170	8;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 170 [Source:HGNC Symbol%3BAcc:HGNC:25358]
ENSG00000240764	0.75	0.86	0.71	0.50	0.83	0.80	0.124492949495571	1.24463830791059	0.640619939427138	0.893883191361236	5:141489120-141512979:+	PCDHGC5	11;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050808,biological_process synapse organization;GO:0070062,cellular_component extracellular exosome	NA	protocadherin gamma subfamily C%2C 5 [Source:HGNC Symbol%3BAcc:HGNC:8718]
ENSG00000162086	8.34	6.53	8.20	8.23	8.50	7.62	-0.0527218607307435	3.43973250169485	0.640789315847932	0.893883191361236	16:3305405-3318852:+	ZNF75A	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 75a [Source:HGNC Symbol%3BAcc:HGNC:13146]
ENSG00000198342	1.39	1.07	0.70	0.72	1.33	1.50	-0.153024963139008	1.1802371645257	0.640858606104523	0.893883191361236	19:12345948-12365905:-	ZNF442	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 442 [Source:HGNC Symbol%3BAcc:HGNC:20877]
ENSG00000113851	30.68	28.61	28.86	29.90	30.64	30.41	-0.0313494425325698	5.50073873475187	0.640925657012042	0.893883191361236	3:3144627-3179727:-	CRBN	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0032463,biological_process negative regulation of protein homooligomerization;GO:0034766,biological_process negative regulation of ion transmembrane transport;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0090073,biological_process positive regulation of protein homodimerization activity	NA	cereblon [Source:HGNC Symbol%3BAcc:HGNC:30185]
ENSG00000143702	18.07	17.48	17.46	17.38	18.25	18.97	-0.0306142965071624	6.51772081494255	0.641029707220305	0.893883191361236	1:243124427-243255348:-	CEP170	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane	NA	centrosomal protein 170 [Source:HGNC Symbol%3BAcc:HGNC:28920]
ENSG00000171885	2.26	2.96	3.34	3.25	2.11	2.54	0.120950978753925	1.48578174136031	0.641106682604359	0.893883191361236	18:26852037-26865818:-	AQP4	17;GO:0003091,biological_process renal water homeostasis;GO:0005215,molecular_function transporter activity;GO:0005372,molecular_function water transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006833,biological_process water transport;GO:0009897,cellular_component external side of plasma membrane;GO:0015250,molecular_function water channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0034220,biological_process ion transmembrane transport;GO:0050891,biological_process multicellular organismal water homeostasis;GO:0071346,biological_process cellular response to interferon-gamma	AQP4; aquaporin-4; K09866	aquaporin 4 [Source:HGNC Symbol%3BAcc:HGNC:637]
ENSG00000100034	10.34	10.30	11.41	9.66	10.60	10.99	0.0492913872757987	4.00273650028785	0.641161897089377	0.893883191361236	22:21919419-21952837:-	PPM1F	30;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006470,biological_process protein dephosphorylation;GO:0006915,biological_process apoptotic process;GO:0010628,biological_process positive regulation of gene expression;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010811,biological_process positive regulation of cell-substrate adhesion;GO:0016576,biological_process histone dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0033192,molecular_function calmodulin-dependent protein phosphatase activity;GO:0035690,biological_process cellular response to drug;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0043169,molecular_function cation binding;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044387,biological_process negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045927,biological_process positive regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050921,biological_process positive regulation of chemotaxis;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0097193,biological_process intrinsic apoptotic signaling pathway	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1F [Source:HGNC Symbol%3BAcc:HGNC:19388]
ENSG00000101654	30.63	30.96	31.40	30.70	31.63	33.50	-0.0324439187650395	5.6305389141324	0.641243561401158	0.893883191361236	18:13726659-13764558:+	RNMT	17;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0004482,molecular_function mRNA (guanine-N7-)-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005845,cellular_component mRNA cap binding complex;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006397,biological_process mRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031533,cellular_component mRNA cap methyltransferase complex;GO:0032259,biological_process methylation;GO:0043235,cellular_component receptor complex;GO:0106005,biological_process RNA 5'-cap (guanine-N7)-methylation;GO:1990830,biological_process cellular response to leukemia inhibitory factor	RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]; K00565	RNA guanine-7 methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:10075]
ENSG00000106052	119.71	116.60	120.87	121.15	120.52	125.26	-0.0267829693453795	8.34387700973846	0.641257331506056	0.893883191361236	7:27739330-27844564:+	TAX1BP1	10;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0019900,molecular_function kinase binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	Tax1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11575]
ENSG00000172197	4.14	4.25	4.86	4.44	4.80	4.78	-0.0684444652184947	2.78949544603835	0.641394249368799	0.893883191361236	6:20102144-20212399:-	MBOAT1	12;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity	MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]; K13517	membrane bound O-acyltransferase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21579]
ENSG00000129354	9.23	9.59	6.82	7.96	10.04	6.47	0.0761480361876485	3.82286365476549	0.641554902797511	0.893883191361236	19:10572670-10587315:-	AP1M2	21;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006605,biological_process protein targeting;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006903,biological_process vesicle targeting;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030131,cellular_component clathrin adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050690,biological_process regulation of defense response to virus by virus	AP1M; AP-1 complex subunit mu; K12393	adaptor related protein complex 1 mu 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:558]
ENSG00000132664	9.24	12.30	12.42	9.87	10.40	12.24	0.0655913725068096	3.40968840524356	0.641627017279862	0.893883191361236	20:18467126-18484643:+	POLR3F	15;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0051607,biological_process defense response to virus	RPC6, POLR3F; DNA-directed RNA polymerase III subunit RPC6; K03025	RNA polymerase III subunit F [Source:HGNC Symbol%3BAcc:HGNC:15763]
ENSG00000163702	17.59	17.85	19.47	19.39	16.17	18.35	0.0386215309593703	5.52772080906896	0.641645642121486	0.893883191361236	3:9917073-9933630:+	IL17RC	13;GO:0005102,molecular_function receptor binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030368,molecular_function interleukin-17 receptor activity;GO:0050832,biological_process defense response to fungus;GO:0071621,biological_process granulocyte chemotaxis;GO:0097398,biological_process cellular response to interleukin-17;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response;GO:2000778,biological_process positive regulation of interleukin-6 secretion	IL17RC, IL17RL; interleukin 17 receptor C; K05166	interleukin 17 receptor C [Source:HGNC Symbol%3BAcc:HGNC:18358]
ENSG00000129028	3.75	4.37	4.37	4.35	5.44	3.74	-0.104274494966776	1.86791800237593	0.641677767401659	0.893883191361236	15:70881341-70892785:-	THAP10	4;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:23193]
ENSG00000187051	77.62	76.19	85.30	79.36	70.60	84.58	0.0406247556616063	5.10706482937151	0.641737441615564	0.893883191361236	22:39529092-39532855:-	RPS19BP1	8;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0019899,molecular_function enzyme binding	NA	ribosomal protein S19 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:28749]
ENSG00000123505	54.05	55.51	56.04	55.45	57.37	57.63	-0.0306473085224865	5.83234079819595	0.641788666834874	0.893883191361236	6:110874769-110895713:+	AMD1	11;GO:0004014,molecular_function adenosylmethionine decarboxylase activity;GO:0005829,cellular_component cytosol;GO:0006557,biological_process S-adenosylmethioninamine biosynthetic process;GO:0006595,biological_process polyamine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0006597,biological_process spermine biosynthetic process;GO:0008295,biological_process spermidine biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0019810,molecular_function putrescine binding;GO:0046500,biological_process S-adenosylmethionine metabolic process	speD, AMD1; S-adenosylmethionine decarboxylase [EC:4.1.1.50]; K01611	adenosylmethionine decarboxylase 1 [Source:HGNC Symbol%3BAcc:HGNC:457]
ENSG00000163608	25.48	24.59	27.11	26.75	25.58	27.39	-0.0327611635008729	5.48307394642098	0.641788739746967	0.893883191361236	3:113002439-113019861:-	NEPRO	5;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0007275,biological_process multicellular organism development;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045747,biological_process positive regulation of Notch signaling pathway	NA	nucleolus and neural progenitor protein [Source:HGNC Symbol%3BAcc:HGNC:24496]
ENSG00000176473	4.26	5.12	5.29	6.13	4.65	4.74	-0.0736006109695742	3.20817245642939	0.641825788257591	0.893883191361236	14:100376417-100530303:+	WDR25	1;GO:0005515,molecular_function protein binding	NA	WD repeat domain 25 [Source:HGNC Symbol%3BAcc:HGNC:21064]
ENSG00000180190	5.21	4.84	3.96	4.95	4.43	3.67	0.116001549921052	1.62259924161891	0.641855742271844	0.893883191361236	8:489791-545781:-	TDRP	6;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007283,biological_process spermatogenesis;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	testis development related protein [Source:HGNC Symbol%3BAcc:HGNC:26951]
ENSG00000117682	16.30	17.02	16.46	17.10	16.84	14.72	0.0441531230933822	4.36986107161332	0.641918895899309	0.893883191361236	1:26432281-26471294:+	DHDDS	10;GO:0002094,molecular_function polyprenyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006489,biological_process dolichyl diphosphate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016094,biological_process polyprenol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016765,molecular_function transferase activity, transferring alkyl or aryl (other than methyl) groups	DHDDS, RER2, SRT1; ditrans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.87]; K11778	dehydrodolichyl diphosphate synthase subunit [Source:HGNC Symbol%3BAcc:HGNC:20603]
ENSG00000196151	27.05	25.16	23.86	25.74	26.45	26.44	-0.0349247036029014	5.20997593602217	0.6419857126388	0.893883191361236	2:159235792-159286799:-	WDSUB1	2;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination	NA	WD repeat%2C sterile alpha motif and U-box domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26697]
ENSG00000115525	4.85	6.37	4.84	4.56	6.89	5.61	-0.0844808036188866	3.52544682044677	0.642077679487398	0.893910973023449	2:85837119-85905199:-	ST3GAL5	18;GO:0000139,cellular_component Golgi membrane;GO:0001574,biological_process ganglioside biosynthetic process;GO:0003836,molecular_function beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0004513,molecular_function neolactotetraosylceramide alpha-2,3-sialyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006688,biological_process glycosphingolipid biosynthetic process;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0047291,molecular_function lactosylceramide alpha-2,3-sialyltransferase activity;GO:0097503,biological_process sialylation	SIAT9; lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9) [EC:2.4.99.9]; K03370	ST3 beta-galactoside alpha-2%2C3-sialyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:10872]
ENSG00000102886	3.08	2.28	4.82	2.88	2.99	3.58	0.137158425823867	1.73983782905273	0.642339734176811	0.894076757339593	16:30104809-30113856:-	GDPD3	7;GO:0006629,biological_process lipid metabolic process;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	glycerophosphodiester phosphodiesterase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28638]
ENSG00000095906	18.50	21.54	18.84	19.84	19.75	17.89	0.0404606519302372	4.70492241747778	0.642398582893247	0.894076757339593	16:1782900-1789191:+	NUBP2	16;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0030030,biological_process cell projection organization;GO:0031616,cellular_component spindle pole centrosome;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding	NA	nucleotide binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:8042]
ENSG00000172955	1.44	1.53	0.92	1.13	2.02	1.19	-0.15538930794119	0.753072186714779	0.642440611592775	0.894076757339593	4:99202637-99219537:-	ADH6	11;GO:0004022,molecular_function alcohol dehydrogenase (NAD) activity;GO:0004024,molecular_function alcohol dehydrogenase activity, zinc-dependent;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006069,biological_process ethanol oxidation;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]; K13952	alcohol dehydrogenase 6 (class V) [Source:HGNC Symbol%3BAcc:HGNC:255]
ENSG00000102890	1.01	1.24	1.78	1.32	1.34	1.06	0.126162425204672	1.6518842085487	0.642484868723852	0.894076757339593	16:67199110-67204029:+	ELMO3	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006909,biological_process phagocytosis;GO:0006915,biological_process apoptotic process;GO:0016477,biological_process cell migration;GO:0017124,molecular_function SH3 domain binding	NA	engulfment and cell motility 3 [Source:HGNC Symbol%3BAcc:HGNC:17289]
ENSG00000125846	8.45	8.98	11.35	9.19	10.16	8.60	0.0568316035907998	4.40586226398512	0.642754326881696	0.894169284179917	20:18288282-18316996:+	ZNF133	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 133 [Source:HGNC Symbol%3BAcc:HGNC:12917]
ENSG00000059915	0.28	0.18	0.56	0.34	0.23	0.32	0.227281369930537	0.281333570508696	0.642806492896468	0.894169284179917	10:102402616-102421539:-	PSD	17;GO:0004871,molecular_function signal transducer activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0031175,biological_process neuron projection development;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0032154,cellular_component cleavage furrow;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0098999,cellular_component extrinsic component of postsynaptic endosome membrane	PSD; PH and SEC7 domain-containing protein; K12494	pleckstrin and Sec7 domain containing [Source:HGNC Symbol%3BAcc:HGNC:9507]
ENSG00000025434	4.89	5.73	5.40	5.06	6.00	5.77	-0.0674149469681027	3.2546924385195	0.642878052224594	0.894169284179917	11:47248299-47269032:+	NR1H3	58;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0010870,biological_process positive regulation of receptor biosynthetic process;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0010887,biological_process negative regulation of cholesterol storage;GO:0015485,molecular_function cholesterol binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032369,biological_process negative regulation of lipid transport;GO:0032376,biological_process positive regulation of cholesterol transport;GO:0032570,biological_process response to progesterone;GO:0032810,molecular_function sterol response element binding;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0042632,biological_process cholesterol homeostasis;GO:0042752,biological_process regulation of circadian rhythm;GO:0043031,biological_process negative regulation of macrophage activation;GO:0043235,cellular_component receptor complex;GO:0043277,biological_process apoptotic cell clearance;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044255,biological_process cellular lipid metabolic process;GO:0045723,biological_process positive regulation of fatty acid biosynthetic process;GO:0045861,biological_process negative regulation of proteolysis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048550,biological_process negative regulation of pinocytosis;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051006,biological_process positive regulation of lipoprotein lipase activity;GO:0055088,biological_process lipid homeostasis;GO:0055092,biological_process sterol homeostasis;GO:0060336,biological_process negative regulation of interferon-gamma-mediated signaling pathway;GO:0070328,biological_process triglyceride homeostasis;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0090188,biological_process negative regulation of pancreatic juice secretion;GO:0090341,biological_process negative regulation of secretion of lysosomal enzymes;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:2000188,biological_process regulation of cholesterol homeostasis;GO:2000189,biological_process positive regulation of cholesterol homeostasis	NR1H3, LXRA; liver X receptor alpha; K08536	nuclear receptor subfamily 1 group H member 3 [Source:HGNC Symbol%3BAcc:HGNC:7966]
ENSG00000170448	6.16	6.06	5.80	6.32	6.03	6.36	-0.0432563961890135	4.1409031432744	0.642910668747317	0.894169284179917	4:47847232-47914667:-	NFXL1	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	nuclear transcription factor%2C X-box binding like 1 [Source:HGNC Symbol%3BAcc:HGNC:18726]
ENSG00000176463	8.32	9.53	8.87	9.19	8.39	8.47	0.0422669822496066	4.29318919210052	0.642977069954252	0.894169284179917	15:91853694-92172435:+	SLCO3A1	10;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015347,molecular_function sodium-independent organic anion transmembrane transporter activity;GO:0015732,biological_process prostaglandin transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043252,biological_process sodium-independent organic anion transport	NA	solute carrier organic anion transporter family member 3A1 [Source:HGNC Symbol%3BAcc:HGNC:10952]
ENSG00000204406	6.33	7.11	7.31	6.30	8.19	7.09	-0.0465010975441459	5.22673586407418	0.642983568081039	0.894169284179917	2:148021010-148516971:+	MBD5	14;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0007399,biological_process nervous system development;GO:0010369,cellular_component chromocenter;GO:0016579,biological_process protein deubiquitination;GO:0030496,cellular_component midbody;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042593,biological_process glucose homeostasis;GO:0044708,biological_process single-organism behavior;GO:0060399,biological_process positive regulation of growth hormone receptor signaling pathway;GO:0070062,cellular_component extracellular exosome	NA	methyl-CpG binding domain protein 5 [Source:HGNC Symbol%3BAcc:HGNC:20444]
ENSG00000213281	68.51	71.46	70.75	69.19	72.90	65.23	0.0346286491972358	5.30933290126315	0.643301852764891	0.89451169467577	1:114704468-114716894:-	NRAS	20;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0032403,molecular_function protein complex binding;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0043312,biological_process neutrophil degranulation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane	NA	NRAS proto-oncogene%2C GTPase [Source:HGNC Symbol%3BAcc:HGNC:7989]
ENSG00000128463	102.72	120.23	109.32	107.04	111.60	108.25	0.031829477840255	6.15361141259025	0.643419481595164	0.894575047607614	15:34224998-34230156:+	EMC4	5;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0072546,cellular_component ER membrane protein complex	NA	ER membrane protein complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:28032]
ENSG00000160961	4.10	3.73	4.14	4.02	3.50	4.08	0.0624899198402413	3.17599803514936	0.643565752681282	0.894678204505852	19:14689800-14733746:+	ZNF333	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 333 [Source:HGNC Symbol%3BAcc:HGNC:15624]
ENSG00000150456	8.25	7.00	8.25	6.18	5.79	10.08	0.105206863731753	2.33915695286247	0.643759657663551	0.894794993208644	13:20728730-20773958:-	EEF1AKMT1	10;GO:0003676,molecular_function nucleic acid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0032259,biological_process methylation;GO:0070062,cellular_component extracellular exosome	NA	EEF1A lysine methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:27351]
ENSG00000128283	27.34	28.43	27.80	30.45	28.58	27.34	-0.0367746788042565	5.0608073816885	0.643807726735158	0.894794993208644	22:37560446-37569405:+	CDC42EP1	17;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0007266,biological_process Rho protein signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0017049,molecular_function GTP-Rho binding;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0043547,biological_process positive regulation of GTPase activity;GO:0098609,biological_process cell-cell adhesion;GO:0098641,molecular_function cadherin binding involved in cell-cell adhesion	NA	CDC42 effector protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17014]
ENSG00000104361	3.78	3.17	4.25	3.12	4.51	4.48	-0.090003679860208	2.25020029091845	0.643901375578072	0.894794993208644	8:98189832-98294393:-	NIPAL2	5;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1903830,biological_process magnesium ion transmembrane transport	NA	NIPA like domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25854]
ENSG00000188687	0.62	0.71	0.69	0.35	0.63	0.85	0.144144543393958	1.31184646722811	0.644032896327426	0.894794993208644	2:74216241-74343414:-	SLC4A5	26;GO:0002064,biological_process epithelial cell development;GO:0003014,biological_process renal system process;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0005215,molecular_function transporter activity;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006820,biological_process anion transport;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0008510,molecular_function sodium:bicarbonate symporter activity;GO:0010468,biological_process regulation of gene expression;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015698,biological_process inorganic anion transport;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0033326,biological_process cerebrospinal fluid secretion;GO:0035725,biological_process sodium ion transmembrane transport;GO:0048311,biological_process mitochondrion distribution;GO:0051453,biological_process regulation of intracellular pH;GO:0060041,biological_process retina development in camera-type eye;GO:0098656,biological_process anion transmembrane transport	SLC4A5, NBC4; solute carrier family 4 (sodium bicarbonate cotransporter), member 5; K13857	solute carrier family 4 member 5 [Source:HGNC Symbol%3BAcc:HGNC:18168]
ENSG00000172840	7.39	9.15	7.79	7.93	7.74	7.80	0.0523118631436931	3.67180169730213	0.64404305199017	0.894794993208644	16:66878588-66895754:+	PDP2	11;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004741,molecular_function [pyruvate dehydrogenase (lipoamide)] phosphatase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006470,biological_process protein dephosphorylation;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016787,molecular_function hydrolase activity;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding	NA	pyruvate dehyrogenase phosphatase catalytic subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:30263]
ENSG00000186919	24.07	24.85	23.12	23.88	26.59	23.92	-0.0361376707338041	5.33349418985357	0.644136399896742	0.894794993208644	17:76071960-76083666:+	ZACN	14;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0010043,biological_process response to zinc ion;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022850,molecular_function serotonin-gated cation channel activity;GO:0034220,biological_process ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	zinc activated ion channel [Source:HGNC Symbol%3BAcc:HGNC:29504]
ENSG00000146966	17.34	18.14	16.48	16.61	17.15	17.43	0.030340808288351	5.73374483349597	0.644206188508108	0.894794993208644	7:140518419-140673993:-	DENND2A	11;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	DENN domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:22212]
ENSG00000112893	18.71	20.02	19.34	19.29	19.36	18.64	0.0295867160366507	6.04742811573364	0.644326001419456	0.894794993208644	5:109689365-109869625:+	MAN2A1	31;GO:0000139,cellular_component Golgi membrane;GO:0001701,biological_process in utero embryonic development;GO:0001889,biological_process liver development;GO:0003824,molecular_function catalytic activity;GO:0004559,molecular_function alpha-mannosidase activity;GO:0004572,molecular_function mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0005797,cellular_component Golgi medial cisterna;GO:0005801,cellular_component cis-Golgi network;GO:0005975,biological_process carbohydrate metabolic process;GO:0006013,biological_process mannose metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006491,biological_process N-glycan processing;GO:0006517,biological_process protein deglycosylation;GO:0007005,biological_process mitochondrion organization;GO:0007033,biological_process vacuole organization;GO:0007585,biological_process respiratory gaseous exchange;GO:0008152,biological_process metabolic process;GO:0015923,molecular_function mannosidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016799,molecular_function hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding;GO:0048286,biological_process lung alveolus development;GO:0050769,biological_process positive regulation of neurogenesis;GO:0060042,biological_process retina morphogenesis in camera-type eye;GO:0070062,cellular_component extracellular exosome	MAN2; alpha-mannosidase II [EC:3.2.1.114]; K01231	mannosidase alpha class 2A member 1 [Source:HGNC Symbol%3BAcc:HGNC:6824]
ENSG00000078304	47.22	50.29	47.98	51.00	48.63	50.01	-0.0299760932247168	7.016447918269	0.644339628035973	0.894794993208644	14:101761797-101927989:+	PPP2R5C	17;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0008233,molecular_function peptidase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050790,biological_process regulation of catalytic activity	PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'; K11584	protein phosphatase 2 regulatory subunit B'gamma [Source:HGNC Symbol%3BAcc:HGNC:9311]
ENSG00000108379	1.39	0.90	1.04	1.12	1.42	1.25	-0.155535217645273	0.516757219915159	0.644370615023932	0.894794993208644	17:46762505-46833154:-	WNT3	46;GO:0000902,biological_process cell morphogenesis;GO:0001707,biological_process mesoderm formation;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007276,biological_process gamete generation;GO:0007411,biological_process axon guidance;GO:0009948,biological_process anterior/posterior axis specification;GO:0009950,biological_process dorsal/ventral axis specification;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010628,biological_process positive regulation of gene expression;GO:0016055,biological_process Wnt signaling pathway;GO:0019904,molecular_function protein domain specific binding;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030182,biological_process neuron differentiation;GO:0030666,cellular_component endocytic vesicle membrane;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0044338,biological_process canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation;GO:0044339,biological_process canonical Wnt signaling pathway involved in osteoblast differentiation;GO:0045165,biological_process cell fate commitment;GO:0048018,molecular_function receptor agonist activity;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048697,biological_process positive regulation of collateral sprouting in absence of injury;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0050767,biological_process regulation of neurogenesis;GO:0060064,biological_process Spemann organizer formation at the anterior end of the primitive streak;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060173,biological_process limb development;GO:0060174,biological_process limb bud formation;GO:0060323,biological_process head morphogenesis;GO:0061180,biological_process mammary gland epithelium development;GO:0070062,cellular_component extracellular exosome;GO:0071300,biological_process cellular response to retinoic acid;GO:0072089,biological_process stem cell proliferation;GO:1904954,biological_process canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;GO:1905474,biological_process canonical Wnt signaling pathway involved in stem cell proliferation;GO:1990909,cellular_component Wnt signalosome	WNT3; wingless-type MMTV integration site family, member 3; K00312	Wnt family member 3 [Source:HGNC Symbol%3BAcc:HGNC:12782]
ENSG00000144504	4.87	5.36	4.79	5.93	4.37	5.42	-0.058738343902107	4.10641004183238	0.644710391845399	0.895126294929545	2:240479421-240569209:-	ANKMY1	1;GO:0046872,molecular_function metal ion binding	NA	ankyrin repeat and MYND domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20987]
ENSG00000166261	7.19	9.05	9.54	8.13	7.92	8.93	0.0514235146245647	4.05101431393238	0.644753420040688	0.895126294929545	11:123724176-123741675:-	ZNF202	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 202 [Source:HGNC Symbol%3BAcc:HGNC:12994]
ENSG00000072506	69.81	77.62	67.21	69.04	78.94	73.64	-0.0378775756418566	5.83431545960217	0.644910655775963	0.895244460987142	X:53431257-53434373:-	HSD17B10	19;GO:0003723,molecular_function RNA binding;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0007005,biological_process mitochondrion organization;GO:0008033,biological_process tRNA processing;GO:0008709,molecular_function cholate 7-alpha-dehydrogenase activity;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0030283,molecular_function testosterone dehydrogenase [NAD(P)] activity;GO:0030678,cellular_component mitochondrial ribonuclease P complex;GO:0047015,molecular_function 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070901,biological_process mitochondrial tRNA methylation;GO:0090646,biological_process mitochondrial tRNA processing	HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]; K08683	hydroxysteroid 17-beta dehydrogenase 10 [Source:HGNC Symbol%3BAcc:HGNC:4800]
ENSG00000087460	265.27	265.31	269.58	274.20	274.74	272.07	-0.0253386757057222	10.1324564904144	0.645174131926599	0.895510063692819	20:58839717-58911192:+	GNAS	76;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001726,cellular_component ruffle;GO:0001894,biological_process tissue homeostasis;GO:0001958,biological_process endochondral ossification;GO:0003091,biological_process renal water homeostasis;GO:0003674,molecular_function molecular_function;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0006112,biological_process energy reserve metabolic process;GO:0006306,biological_process DNA methylation;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007191,biological_process adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007565,biological_process female pregnancy;GO:0007606,biological_process sensory perception of chemical stimulus;GO:0007608,biological_process sensory perception of smell;GO:0009306,biological_process protein secretion;GO:0009791,biological_process post-embryonic development;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0030133,cellular_component transport vesicle;GO:0030425,cellular_component dendrite;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031224,cellular_component intrinsic component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031698,molecular_function beta-2 adrenergic receptor binding;GO:0031748,molecular_function D1 dopamine receptor binding;GO:0031852,molecular_function mu-type opioid receptor binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035264,biological_process multicellular organism growth;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0040032,biological_process post-embryonic body morphogenesis;GO:0042493,biological_process response to drug;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043588,biological_process skin development;GO:0043950,biological_process positive regulation of cAMP-mediated signaling;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0046872,molecular_function metal ion binding;GO:0046907,biological_process intracellular transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048589,biological_process developmental growth;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0050796,biological_process regulation of insulin secretion;GO:0050890,biological_process cognition;GO:0051216,biological_process cartilage development;GO:0051430,molecular_function corticotropin-releasing hormone receptor 1 binding;GO:0060348,biological_process bone development;GO:0060789,biological_process hair follicle placode formation;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0071107,biological_process response to parathyroid hormone;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071514,biological_process genetic imprinting;GO:0071870,biological_process cellular response to catecholamine stimulus;GO:0071880,biological_process adenylate cyclase-activating adrenergic receptor signaling pathway;GO:2000828,biological_process regulation of parathyroid hormone secretion	NA	GNAS complex locus [Source:HGNC Symbol%3BAcc:HGNC:4392]
ENSG00000165684	5.61	5.92	5.90	5.90	5.66	5.54	0.0377478209594622	4.67235686402566	0.645369321122639	0.89552944546131	9:136375576-136400168:-	SNAPC4	18;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001135,molecular_function transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0009301,biological_process snRNA transcription;GO:0019185,cellular_component snRNA-activating protein complex;GO:0030154,biological_process cell differentiation;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042796,biological_process snRNA transcription from RNA polymerase III promoter;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding	NA	small nuclear RNA activating complex polypeptide 4 [Source:HGNC Symbol%3BAcc:HGNC:11137]
ENSG00000085719	55.76	53.09	58.02	53.73	55.79	55.35	0.030934669984235	6.48081985485763	0.645383000920482	0.89552944546131	8:86514426-86561498:+	CPNE3	27;GO:0003723,molecular_function RNA binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0035577,cellular_component azurophil granule membrane;GO:0038128,biological_process ERBB2 signaling pathway;GO:0043312,biological_process neutrophil degranulation;GO:0046474,biological_process glycerophospholipid biosynthetic process;GO:0048306,molecular_function calcium-dependent protein binding;GO:0070062,cellular_component extracellular exosome;GO:0071277,biological_process cellular response to calcium ion;GO:0071363,biological_process cellular response to growth factor stimulus	NA	copine 3 [Source:HGNC Symbol%3BAcc:HGNC:2316]
ENSG00000108788	22.44	22.98	24.45	22.19	21.89	24.30	0.0418178924857535	4.37641846891806	0.645404529049938	0.89552944546131	17:42567067-42573239:+	MLX	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0031965,cellular_component nuclear membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity	MLX; MAX-like protein X; K09113	MLX%2C MAX dimerization protein [Source:HGNC Symbol%3BAcc:HGNC:11645]
ENSG00000172534	10.01	11.67	10.00	11.27	10.88	10.54	-0.037211970753632	6.06696860150247	0.645570359849709	0.895659425149709	X:153947552-153971807:-	HCFC1	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000123,cellular_component histone acetyltransferase complex;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007005,biological_process mitochondrion organization;GO:0007049,biological_process cell cycle;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0019046,biological_process release from viral latency;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0033613,molecular_function activating transcription factor binding;GO:0042802,molecular_function identical protein binding;GO:0043025,cellular_component neuronal cell body;GO:0043254,biological_process regulation of protein complex assembly;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0045296,molecular_function cadherin binding;GO:0045787,biological_process positive regulation of cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific);GO:0048188,cellular_component Set1C/COMPASS complex;GO:0050821,biological_process protein stabilization;GO:0070461,cellular_component SAGA-type complex;GO:0071339,cellular_component MLL1 complex;GO:0071407,biological_process cellular response to organic cyclic compound	HCFC; host cell factor; K14966	host cell factor C1 [Source:HGNC Symbol%3BAcc:HGNC:4839]
ENSG00000130803	17.06	18.71	18.69	18.08	17.18	18.23	0.0342417020538628	5.07002587951421	0.645731905013013	0.895665534878258	19:9140379-9163424:+	ZNF317	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 317 [Source:HGNC Symbol%3BAcc:HGNC:13507]
ENSG00000112742	21.47	24.96	20.34	21.62	26.04	21.61	-0.044545988791366	5.9065467084494	0.645773545332893	0.895665534878258	6:80003886-80042527:+	TTK	32;GO:0000166,molecular_function nucleotide binding;GO:0000776,cellular_component kinetochore;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0006468,biological_process protein phosphorylation;GO:0007051,biological_process spindle organization;GO:0007052,biological_process mitotic spindle organization;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016321,biological_process female meiosis chromosome segregation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0033316,biological_process meiotic spindle assembly checkpoint;GO:0034501,biological_process protein localization to kinetochore;GO:0034502,biological_process protein localization to chromosome;GO:0042803,molecular_function protein homodimerization activity;GO:0046777,biological_process protein autophosphorylation;GO:0051304,biological_process chromosome separation;GO:1903096,biological_process protein localization to meiotic spindle midzone	TTK, MPS1; serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]; K08866	TTK protein kinase [Source:HGNC Symbol%3BAcc:HGNC:12401]
ENSG00000169231	20.05	18.86	23.25	21.30	18.11	21.53	0.0422200768855898	5.88512010007767	0.645812437643144	0.895665534878258	1:155195587-155209051:-	THBS3	9;GO:0003417,biological_process growth plate cartilage development;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0008201,molecular_function heparin binding;GO:0043931,biological_process ossification involved in bone maturation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060346,biological_process bone trabecula formation	THBS2S; thrombospondin 2/3/4/5; K04659	thrombospondin 3 [Source:HGNC Symbol%3BAcc:HGNC:11787]
ENSG00000198918	3046.14	2655.85	2700.15	2969.92	2712.48	2980.94	-0.0321323822548398	8.76700337593629	0.645863385377852	0.895665534878258	X:119786503-119791643:-	RPL39	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002227,biological_process innate immune response in mucosa;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0019731,biological_process antibacterial humoral response;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0061844,biological_process antimicrobial humoral immune response mediated by antimicrobial peptide	NA	ribosomal protein L39 [Source:HGNC Symbol%3BAcc:HGNC:10350]
ENSG00000165181	0.95	0.91	0.97	1.18	0.85	1.00	-0.0861105385038118	2.25137124501743	0.646193736427447	0.896023553426486	9:111686172-111795008:-	C9orf84	NA	NA	chromosome 9 open reading frame 84 [Source:HGNC Symbol%3BAcc:HGNC:26535]
ENSG00000034533	6.22	6.86	7.06	7.07	6.15	6.35	0.0497574912325811	3.85077891138909	0.646377305330608	0.896166444196773	3:131013874-131027649:-	ASTE1	4;GO:0004518,molecular_function nuclease activity;GO:0005515,molecular_function protein binding;GO:0006281,biological_process DNA repair;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	asteroid homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:25021]
ENSG00000172175	39.23	36.03	41.71	40.13	35.44	39.63	0.0355382606538469	6.58396005696039	0.646441177905253	0.896166444196773	18:58671385-58754477:+	MALT1	42;GO:0001650,cellular_component fibrillar center;GO:0001923,biological_process B-1 B cell differentiation;GO:0002020,molecular_function protease binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002237,biological_process response to molecule of bacterial origin;GO:0002726,biological_process positive regulation of T cell cytokine production;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006952,biological_process defense response;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0008233,molecular_function peptidase activity;GO:0009620,biological_process response to fungus;GO:0016567,biological_process protein ubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019209,molecular_function kinase activator activity;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032449,cellular_component CBM complex;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042098,biological_process T cell proliferation;GO:0042113,biological_process B cell activation;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043621,molecular_function protein self-association;GO:0045087,biological_process innate immune response;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050856,biological_process regulation of T cell receptor signaling pathway;GO:0050870,biological_process positive regulation of T cell activation;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051168,biological_process nuclear export;GO:0051259,biological_process protein oligomerization	MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]; K07369	MALT1 paracaspase [Source:HGNC Symbol%3BAcc:HGNC:6819]
ENSG00000145365	21.11	24.06	20.00	24.14	23.49	20.64	-0.0624642670693305	3.6317330217333	0.646613290151381	0.896283634324239	4:112274541-112285903:-	TIFA	3;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling	NA	TRAF interacting protein with forkhead associated domain [Source:HGNC Symbol%3BAcc:HGNC:19075]
ENSG00000146083	11.79	10.45	13.84	12.86	13.64	11.41	-0.0511574200836879	4.19996763373795	0.646692197039142	0.896283634324239	5:176526696-176538025:-	RNF44	4;GO:0016567,biological_process protein ubiquitination;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 44 [Source:HGNC Symbol%3BAcc:HGNC:19180]
ENSG00000178691	27.36	28.06	26.79	29.01	27.85	27.72	-0.0303455602490126	5.9496734362971	0.646760631902056	0.896283634324239	17:31937017-32001045:+	SUZ12	29;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001739,cellular_component sex chromatin;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016574,biological_process histone ubiquitination;GO:0016586,cellular_component RSC complex;GO:0016604,cellular_component nuclear body;GO:0031490,molecular_function chromatin DNA binding;GO:0032993,cellular_component protein-DNA complex;GO:0035064,molecular_function methylated histone binding;GO:0035098,cellular_component ESC/E(Z) complex;GO:0042054,molecular_function histone methyltransferase activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0046976,molecular_function histone methyltransferase activity (H3-K27 specific);GO:0070734,biological_process histone H3-K27 methylation;GO:1990841,molecular_function promoter-specific chromatin binding	NA	SUZ12 polycomb repressive complex 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:17101]
ENSG00000149798	9.08	7.43	9.23	9.15	5.18	9.82	0.10790176014241	2.4401935426199	0.646814532850764	0.896283634324239	11:65314817-65322429:+	CDC42EP2	19;GO:0001515,molecular_function opioid peptide activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007015,biological_process actin filament organization;GO:0007266,biological_process Rho protein signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0012505,cellular_component endomembrane system;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0017049,molecular_function GTP-Rho binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031274,biological_process positive regulation of pseudopodium assembly;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0043547,biological_process positive regulation of GTPase activity	NA	CDC42 effector protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16263]
ENSG00000138138	35.02	34.33	34.39	36.78	35.86	34.41	-0.0325090804179989	5.25652292774618	0.646923623914458	0.89633474089186	10:87751511-87841343:-	ATAD1	17;GO:0000166,molecular_function nucleotide binding;GO:0002092,biological_process positive regulation of receptor internalization;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005886,cellular_component plasma membrane;GO:0007612,biological_process learning;GO:0007613,biological_process memory;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0051967,biological_process negative regulation of synaptic transmission, glutamatergic	NA	ATPase family%2C AAA domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25903]
ENSG00000155868	26.98	27.07	25.38	27.64	26.37	28.47	-0.0452581840175354	4.24976270929513	0.647052383314053	0.896413084160417	5:157137411-157159019:-	MED7	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0016604,cellular_component nuclear body;GO:0019827,biological_process stem cell population maintenance;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	mediator complex subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:2378]
ENSG00000145390	7.46	7.02	6.84	7.38	7.57	7.17	-0.0386384653832278	4.5570457231362	0.647304481349947	0.896589022831275	4:119212586-119295517:+	USP53	13;GO:0001508,biological_process action potential;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006915,biological_process apoptotic process;GO:0007605,biological_process sensory perception of sound;GO:0008150,biological_process biological_process;GO:0010996,biological_process response to auditory stimulus;GO:0016579,biological_process protein deubiquitination;GO:0030054,cellular_component cell junction;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0051402,biological_process neuron apoptotic process	NA	ubiquitin specific peptidase 53 [Source:HGNC Symbol%3BAcc:HGNC:29255]
ENSG00000136870	12.51	10.23	11.63	11.42	12.18	12.21	-0.0393636664764186	4.56171214737345	0.647359427108896	0.896589022831275	9:101398872-101410660:+	ZNF189	9;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 189 [Source:HGNC Symbol%3BAcc:HGNC:12980]
ENSG00000114120	49.30	44.57	53.49	49.89	46.48	48.74	0.0379783286343701	5.62869377353164	0.647396069575181	0.896589022831275	3:140941829-140979933:+	SLC25A36	13;GO:0000002,biological_process mitochondrial genome maintenance;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0006864,biological_process pyrimidine nucleotide transport;GO:0007005,biological_process mitochondrion organization;GO:0015218,molecular_function pyrimidine nucleotide transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055085,biological_process transmembrane transport;GO:1990519,biological_process mitochondrial pyrimidine nucleotide import	NA	solute carrier family 25 member 36 [Source:HGNC Symbol%3BAcc:HGNC:25554]
ENSG00000155099	21.66	18.42	21.97	22.00	16.93	21.40	0.0575361861976698	4.13531470631016	0.647473182871659	0.896595785250547	8:90993795-91041064:-	TMEM55A	9;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031902,cellular_component late endosome membrane;GO:0034597,molecular_function phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity;GO:0046856,biological_process phosphatidylinositol dephosphorylation	TMEM55; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]; K13084	transmembrane protein 55A [Source:HGNC Symbol%3BAcc:HGNC:25452]
ENSG00000248333	14.29	13.76	16.44	15.28	14.61	16.21	-0.0368421999362406	5.40881693248414	0.647639617788156	0.896726221484035	1:1635226-1659012:-	CDK11B	4;GO:0004672,molecular_function protein kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0051301,biological_process cell division	NA	cyclin dependent kinase 11B [Source:HGNC Symbol%3BAcc:HGNC:1729]
ENSG00000132383	61.95	61.54	58.27	61.34	64.39	61.26	-0.0295384508290721	6.83020728539996	0.647827156455822	0.896731389704125	17:1829701-1900082:+	RPA1	39;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005662,cellular_component DNA replication factor A complex;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006284,biological_process base-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016605,cellular_component PML body;GO:0019985,biological_process translesion synthesis;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034502,biological_process protein localization to chromosome;GO:0036297,biological_process interstrand cross-link repair;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0046872,molecular_function metal ion binding;GO:0070987,biological_process error-free translesion synthesis;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RFA1, RPA1, rpa; replication factor A1; K07466	replication protein A1 [Source:HGNC Symbol%3BAcc:HGNC:10289]
ENSG00000154310	12.97	13.56	13.55	12.89	13.69	12.96	0.0302264626233783	5.80248019647478	0.647882128882966	0.896731389704125	3:171061338-171460408:-	TNIK	33;GO:0000166,molecular_function nucleotide binding;GO:0000185,biological_process activation of MAPKKK activity;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0007010,biological_process cytoskeleton organization;GO:0007256,biological_process activation of JNKK activity;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007399,biological_process nervous system development;GO:0008349,molecular_function MAP kinase kinase kinase kinase activity;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0030033,biological_process microvillus assembly;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0035556,biological_process intracellular signal transduction;GO:0042981,biological_process regulation of apoptotic process;GO:0046777,biological_process protein autophosphorylation;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane	TNIK; TRAF2 and NCK interacting kinase [EC:2.7.11.1]; K08840	TRAF2 and NCK interacting kinase [Source:HGNC Symbol%3BAcc:HGNC:30765]
ENSG00000134285	11.92	11.57	15.09	13.41	13.35	10.48	0.0697258762787643	3.62948793032985	0.647899380307253	0.896731389704125	12:48921517-48926474:-	FKBP11	8;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005528,molecular_function FK506 binding;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016853,molecular_function isomerase activity;GO:0061077,biological_process chaperone-mediated protein folding	NA	FK506 binding protein 11 [Source:HGNC Symbol%3BAcc:HGNC:18624]
ENSG00000102471	30.83	32.52	29.35	25.48	33.78	31.18	0.0449094104867336	4.94949779394906	0.647960360422627	0.896731389704125	13:79481123-79556075:+	NDFIP2	24;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0007034,biological_process vacuolar transport;GO:0007165,biological_process signal transduction;GO:0010008,cellular_component endosome membrane;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032410,biological_process negative regulation of transporter activity;GO:0032585,cellular_component multivesicular body membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050699,molecular_function WW domain binding;GO:0051224,biological_process negative regulation of protein transport	NA	Nedd4 family interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18537]
ENSG00000198130	25.24	24.14	25.54	24.89	27.16	25.38	-0.032894428096459	5.20102135324532	0.648004556968178	0.896731389704125	2:190189734-190344193:-	HIBCH	7;GO:0003860,molecular_function 3-hydroxyisobutyryl-CoA hydrolase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006574,biological_process valine catabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	HIBCH; 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4]; K05605	3-hydroxyisobutyryl-CoA hydrolase [Source:HGNC Symbol%3BAcc:HGNC:4908]
ENSG00000101363	125.47	129.17	119.43	131.92	114.74	120.55	0.0361878365139356	5.08203543039844	0.648191272332937	0.896876908394151	20:37289637-37317260:+	MANBAL	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	mannosidase beta like [Source:HGNC Symbol%3BAcc:HGNC:15799]
ENSG00000178026	17.59	14.41	15.99	15.60	17.15	17.44	-0.0449891361878682	4.06277731447716	0.64825421913416	0.896876908394151	22:24585619-24593208:-	LRRC75B	NA	NA	leucine rich repeat containing 75B [Source:HGNC Symbol%3BAcc:HGNC:33155]
ENSG00000141401	196.40	217.03	188.87	195.69	230.17	196.80	-0.0368719867305154	7.8358554127607	0.648416001104849	0.896994442909014	18:11981024-12030883:+	IMPA2	17;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006020,biological_process inositol metabolic process;GO:0006021,biological_process inositol biosynthetic process;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0007165,biological_process signal transduction;GO:0008934,molecular_function inositol monophosphate 1-phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046872,molecular_function metal ion binding;GO:0052832,molecular_function inositol monophosphate 3-phosphatase activity;GO:0052833,molecular_function inositol monophosphate 4-phosphatase activity;GO:0052834,molecular_function inositol monophosphate phosphatase activity	E3.1.3.25, IMPA, suhB; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]; K01092	inositol monophosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:6051]
ENSG00000174177	5.12	5.79	6.02	5.39	6.25	6.14	-0.0622227021619511	3.4271795801429	0.648483696984249	0.896994442909014	16:88706462-88715386:+	CTU2	13;GO:0000049,molecular_function tRNA binding;GO:0002098,biological_process tRNA wobble uridine modification;GO:0002143,biological_process tRNA wobble position uridine thiolation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016783,molecular_function sulfurtransferase activity;GO:0032447,biological_process protein urmylation;GO:0034227,biological_process tRNA thio-modification;GO:0043234,cellular_component protein complex	CTU2, NCS2; cytoplasmic tRNA 2-thiolation protein 2; K14169	cytosolic thiouridylase subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:28005]
ENSG00000047578	9.61	9.97	9.51	9.81	9.55	9.33	0.0303588123057524	5.5977333802281	0.648643182570456	0.897025342245828	16:27550132-27780369:+	KIAA0556	4;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0042995,cellular_component cell projection	NA	KIAA0556 [Source:HGNC Symbol%3BAcc:HGNC:29068]
ENSG00000176681	0.47	0.51	0.48	0.56	0.46	0.55	-0.1072035230116	1.44538732728004	0.64868027587362	0.897025342245828	17:46292732-46337794:+	LRRC37A	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	leucine rich repeat containing 37A [Source:HGNC Symbol%3BAcc:HGNC:29069]
ENSG00000166596	1.59	1.65	1.31	1.37	1.58	1.95	-0.109915703484659	1.66282726717309	0.648722830688858	0.897025342245828	17:9576626-9643459:+	CFAP52	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0042995,cellular_component cell projection	NA	cilia and flagella associated protein 52 [Source:HGNC Symbol%3BAcc:HGNC:16053]
ENSG00000135541	6.16	6.14	6.36	5.77	6.36	6.19	0.0395697360103066	4.57076253018245	0.648944832073903	0.8972323680701	6:135283531-135497776:-	AHI1	40;GO:0001738,biological_process morphogenesis of a polarized epithelium;GO:0001947,biological_process heart looping;GO:0002092,biological_process positive regulation of receptor internalization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005929,cellular_component cilium;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007417,biological_process central nervous system development;GO:0010842,biological_process retina layer formation;GO:0016192,biological_process vesicle-mediated transport;GO:0030030,biological_process cell projection organization;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030862,biological_process positive regulation of polarized epithelial cell differentiation;GO:0030902,biological_process hindbrain development;GO:0034613,biological_process cellular protein localization;GO:0035844,biological_process cloaca development;GO:0035845,biological_process photoreceptor cell outer segment organization;GO:0036038,cellular_component MKS complex;GO:0036064,cellular_component ciliary basal body;GO:0039008,biological_process pronephric nephron tubule morphogenesis;GO:0039023,biological_process pronephric duct morphogenesis;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050795,biological_process regulation of behavior;GO:0060271,biological_process cilium morphogenesis;GO:0065001,biological_process specification of axis polarity;GO:0070121,biological_process Kupffer's vesicle development;GO:0070986,biological_process left/right axis specification;GO:0071599,biological_process otic vesicle development;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0097730,cellular_component non-motile cilium	NA	Abelson helper integration site 1 [Source:HGNC Symbol%3BAcc:HGNC:21575]
ENSG00000120662	6.04	6.22	5.67	5.51	5.10	6.61	0.0638459210667077	3.07661864226196	0.649035411402901	0.897257663631163	13:41216368-41263577:-	MTRF1	5;GO:0003747,molecular_function translation release factor activity;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0006415,biological_process translational termination;GO:0006449,biological_process regulation of translational termination	NA	mitochondrial translation release factor 1 [Source:HGNC Symbol%3BAcc:HGNC:7469]
ENSG00000160294	14.87	14.61	14.37	14.97	13.90	14.44	0.0294141181818434	6.43481584310177	0.649348731198481	0.897554809527476	21:46235125-46286297:-	MCM3AP	16;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0031965,cellular_component nuclear membrane;GO:0051028,biological_process mRNA transport	NA	minichromosome maintenance complex component 3 associated protein [Source:HGNC Symbol%3BAcc:HGNC:6946]
ENSG00000136930	162.71	171.54	164.07	170.76	172.50	168.81	-0.0283005743065428	7.32529080413824	0.649394968530271	0.897554809527476	9:124353465-124415444:-	PSMB7	45;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMB7; 20S proteasome subunit beta 2 [EC:3.4.25.1]; K02739	proteasome subunit beta 7 [Source:HGNC Symbol%3BAcc:HGNC:9544]
ENSG00000166037	40.42	40.82	40.79	41.50	42.22	41.77	-0.0287581684157195	6.10164169134259	0.649572364079556	0.89759211500341	11:95789964-95832693:+	CEP57	23;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007286,biological_process spermatid development;GO:0008017,molecular_function microtubule binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0017134,molecular_function fibroblast growth factor binding;GO:0034453,biological_process microtubule anchoring;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043015,molecular_function gamma-tubulin binding;GO:0051260,biological_process protein homooligomerization;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 57 [Source:HGNC Symbol%3BAcc:HGNC:30794]
ENSG00000100852	39.79	40.74	41.59	40.94	39.68	40.20	0.027245109759252	7.53569337812773	0.649626060627106	0.89759211500341	14:32076113-32159728:+	ARHGAP5	15;GO:0003924,molecular_function GTPase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0016020,cellular_component membrane;GO:0030879,biological_process mammary gland development;GO:0042169,molecular_function SH2 domain binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	ARHGAP5; Rho GTPase-activating protein 5; K13709	Rho GTPase activating protein 5 [Source:HGNC Symbol%3BAcc:HGNC:675]
ENSG00000243708	0.21	0.33	0.44	0.45	0.26	0.45	-0.241087713841343	-0.0174960262798428	0.649720174284092	0.89759211500341	15:41837774-41848147:+	PLA2G4B	34;GO:0004620,molecular_function phospholipase activity;GO:0004622,molecular_function lysophospholipase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006954,biological_process inflammatory response;GO:0007567,biological_process parturition;GO:0008152,biological_process metabolic process;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0009395,biological_process phospholipid catabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0019722,biological_process calcium-mediated signaling;GO:0031901,cellular_component early endosome membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047498,molecular_function calcium-dependent phospholipase A2 activity	PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]; K16342	phospholipase A2 group IVB [Source:HGNC Symbol%3BAcc:HGNC:9036]
ENSG00000168152	3.61	3.20	3.49	3.23	3.68	3.92	-0.0564597879195893	3.3193413650696	0.64984941797438	0.89759211500341	4:82900683-82919969:+	THAP9	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004803,molecular_function transposase activity;GO:0006310,biological_process DNA recombination;GO:0006313,biological_process transposition, DNA-mediated;GO:0015074,biological_process DNA integration;GO:0016740,molecular_function transferase activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:23192]
ENSG00000142784	14.88	15.53	15.73	15.23	15.35	14.82	0.0344555685939272	4.96052223582042	0.649865756966081	0.89759211500341	1:27234515-27308633:+	WDTC1	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001701,biological_process in utero embryonic development;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006006,biological_process glucose metabolic process;GO:0008361,biological_process regulation of cell size;GO:0016567,biological_process protein ubiquitination;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035264,biological_process multicellular organism growth;GO:0042393,molecular_function histone binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043687,biological_process post-translational protein modification;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0055082,biological_process cellular chemical homeostasis	NA	WD and tetratricopeptide repeats 1 [Source:HGNC Symbol%3BAcc:HGNC:29175]
ENSG00000170632	65.30	61.04	62.14	64.02	64.28	65.66	-0.0281947202517689	6.26992149238885	0.649881803996911	0.89759211500341	7:103074880-103099764:+	ARMC10	6;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0040008,biological_process regulation of growth	NA	armadillo repeat containing 10 [Source:HGNC Symbol%3BAcc:HGNC:21706]
ENSG00000139684	78.50	78.42	74.46	83.61	78.10	76.51	-0.0307831254662734	6.20781355089703	0.649928134185986	0.89759211500341	13:46771255-46797232:-	ESD	14;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0018738,molecular_function S-formylglutathione hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042802,molecular_function identical protein binding;GO:0046294,biological_process formaldehyde catabolic process;GO:0047374,molecular_function methylumbelliferyl-acetate deacetylase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:1901687,biological_process glutathione derivative biosynthetic process	NA	esterase D [Source:HGNC Symbol%3BAcc:HGNC:3465]
ENSG00000186088	9.59	8.73	10.72	10.46	7.90	9.91	0.0535740617739037	4.62604247209428	0.650072500931916	0.897691617985078	7:77310750-77416400:-	GSAP	5;GO:0001540,molecular_function beta-amyloid binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0030162,biological_process regulation of proteolysis;GO:1902004,biological_process positive regulation of beta-amyloid formation	NA	gamma-secretase activating protein [Source:HGNC Symbol%3BAcc:HGNC:28042]
ENSG00000111785	5.63	5.59	4.73	5.12	5.66	5.97	-0.0632008575134082	3.41656806973661	0.650448706091002	0.897762121870538	12:106774594-106889316:+	RIC8B	10;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0043547,biological_process positive regulation of GTPase activity	NA	RIC8 guanine nucleotide exchange factor B [Source:HGNC Symbol%3BAcc:HGNC:25555]
ENSG00000128534	96.95	91.41	87.77	89.29	82.20	99.14	0.0400294437642316	4.8840452030152	0.65056526659394	0.897762121870538	7:118184031-118192824:+	LSM8	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005688,cellular_component U6 snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0017070,molecular_function U6 snRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071011,cellular_component precatalytic spliceosome	NA	LSM8 homolog%2C U6 small nuclear RNA associated [Source:HGNC Symbol%3BAcc:HGNC:20471]
ENSG00000106346	5.52	5.88	6.82	5.63	6.60	6.75	-0.0474220400677486	4.67193545428914	0.65058920421341	0.897762121870538	7:6104883-6161564:+	USP42	12;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007283,biological_process spermatogenesis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 42 [Source:HGNC Symbol%3BAcc:HGNC:20068]
ENSG00000132792	23.87	23.02	23.42	24.52	22.02	22.74	0.0342013261810683	5.32827529400523	0.650622415952143	0.897762121870538	20:37693954-37872129:+	CTNNBL1	14;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016445,biological_process somatic diversification of immunoglobulins;GO:0019899,molecular_function enzyme binding;GO:0043065,biological_process positive regulation of apoptotic process	CTNNBL1; beta-catenin-like protein 1; K12864	catenin beta like 1 [Source:HGNC Symbol%3BAcc:HGNC:15879]
ENSG00000163666	2.67	2.07	1.72	2.97	1.78	2.53	-0.152984307558631	0.516988898426403	0.650710629096381	0.897762121870538	3:57197842-57226521:-	HESX1	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0008022,molecular_function protein C-terminus binding;GO:0021983,biological_process pituitary gland development;GO:0030916,biological_process otic vesicle formation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043584,biological_process nose development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0047485,molecular_function protein N-terminus binding;GO:0048853,biological_process forebrain morphogenesis	HESX1; homeobox protein expressed in ES cells 1; K09354	HESX homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:4877]
ENSG00000124459	7.28	6.49	7.34	7.47	7.30	7.32	-0.0458365497453869	3.90003427847326	0.650771863069601	0.897762121870538	19:43912628-43935278:-	ZNF45	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 45 [Source:HGNC Symbol%3BAcc:HGNC:13111]
ENSG00000101400	22.33	24.47	21.42	21.70	24.48	24.32	-0.0404122014014139	5.13587785378293	0.650818337445931	0.897762121870538	20:33407954-33443892:-	SNTA1	27;GO:0002027,biological_process regulation of heart rate;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006936,biological_process muscle contraction;GO:0016013,cellular_component syntrophin complex;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0017080,molecular_function sodium channel regulator activity;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0031594,cellular_component neuromuscular junction;GO:0042383,cellular_component sarcolemma;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0051117,molecular_function ATPase binding;GO:0060307,biological_process regulation of ventricular cardiac muscle cell membrane repolarization;GO:0065009,biological_process regulation of molecular function;GO:0086005,biological_process ventricular cardiac muscle cell action potential;GO:1902083,biological_process negative regulation of peptidyl-cysteine S-nitrosylation;GO:1902305,biological_process regulation of sodium ion transmembrane transport	NA	syntrophin alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:11167]
ENSG00000177971	31.47	29.60	30.67	32.28	27.62	29.68	0.0488787877028002	4.0750807030438	0.650893046576983	0.897762121870538	15:75639084-75648706:-	IMP3	12;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032040,cellular_component small-subunit processome;GO:0034457,cellular_component Mpp10 complex;GO:0042254,biological_process ribosome biogenesis	IMP3; U3 small nucleolar ribonucleoprotein protein IMP3; K14560	IMP3%2C U3 small nucleolar ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:14497]
ENSG00000128965	14.80	11.70	14.40	13.23	13.12	13.50	0.0619106614831147	3.44148631982876	0.650903932699445	0.897762121870538	15:40952961-40956519:+	CHAC1	19;GO:0003839,molecular_function gamma-glutamylcyclotransferase activity;GO:0005112,molecular_function Notch binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006750,biological_process glutathione biosynthetic process;GO:0006751,biological_process glutathione catabolic process;GO:0006915,biological_process apoptotic process;GO:0006986,biological_process response to unfolded protein;GO:0007219,biological_process Notch signaling pathway;GO:0007399,biological_process nervous system development;GO:0010955,biological_process negative regulation of protein processing;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0022008,biological_process neurogenesis;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	CHAC, chaC; glutathione-specific gamma-glutamylcyclotransferase [EC:4.3.2.7]; K07232	ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:28680]
ENSG00000183155	12.63	16.06	13.16	14.81	13.98	10.67	0.0866265764760832	2.35424231846722	0.650934348377348	0.897762121870538	1:202878956-202889135:-	RABIF	12;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0061025,biological_process membrane fusion	NA	RAB interacting factor [Source:HGNC Symbol%3BAcc:HGNC:9797]
ENSG00000100354	4.42	4.27	3.59	3.95	4.55	3.43	0.0531347219072081	4.50958089015733	0.650941747278329	0.897762121870538	22:40044816-40335808:+	TNRC6B	16;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0031047,biological_process gene silencing by RNA;GO:0035194,biological_process posttranscriptional gene silencing by RNA;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	NA	trinucleotide repeat containing 6B [Source:HGNC Symbol%3BAcc:HGNC:29190]
ENSG00000066135	28.28	28.80	28.02	27.19	31.77	28.79	-0.0327961684552504	6.52584265672115	0.651033454254823	0.897762121870538	1:43650157-43705515:+	KDM4A	34;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005721,cellular_component pericentric heterochromatin;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0010507,biological_process negative regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0016032,biological_process viral process;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016577,biological_process histone demethylation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031667,biological_process response to nutrient levels;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0035064,molecular_function methylated histone binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048712,biological_process negative regulation of astrocyte differentiation;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0060548,biological_process negative regulation of cell death;GO:0070544,biological_process histone H3-K36 demethylation;GO:1900113,biological_process negative regulation of histone H3-K9 trimethylation	NA	lysine demethylase 4A [Source:HGNC Symbol%3BAcc:HGNC:22978]
ENSG00000006015	23.05	22.23	24.38	18.87	25.85	22.83	0.0587651319299419	3.8403174485069	0.651063773550196	0.897762121870538	19:18588684-18592336:+	C19orf60	1;GO:0005515,molecular_function protein binding	NA	chromosome 19 open reading frame 60 [Source:HGNC Symbol%3BAcc:HGNC:26098]
ENSG00000156384	14.41	8.58	13.12	12.12	10.42	12.05	0.0894970955888503	3.15440563482588	0.651338512905297	0.897860797105209	10:104122057-104126385:+	SFR1	11;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0032798,cellular_component Swi5-Sfr1 complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0071391,biological_process cellular response to estrogen stimulus	NA	SWI5 dependent homologous recombination repair protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29574]
ENSG00000146267	2.65	3.66	2.76	2.93	3.21	3.55	-0.108786412769395	1.98835348634592	0.651347936306551	0.897860797105209	6:99271168-99350062:-	FAXC	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	failed axon connections homolog [Source:HGNC Symbol%3BAcc:HGNC:20742]
ENSG00000196967	0.48	0.93	1.06	0.86	0.48	0.87	0.157575572217863	0.983367111444914	0.651352330454557	0.897860797105209	19:37106733-37172741:-	ZNF585A	7;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 585A [Source:HGNC Symbol%3BAcc:HGNC:26305]
ENSG00000160194	13.24	13.07	12.14	12.61	12.29	12.69	0.042333535056152	4.18058035624251	0.651583109051914	0.89807918417293	21:42879643-42913304:+	NDUFV3	12;GO:0003723,molecular_function RNA binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0042775,biological_process mitochondrial ATP synthesis coupled electron transport;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3; K03944	NADH:ubiquinone oxidoreductase subunit V3 [Source:HGNC Symbol%3BAcc:HGNC:7719]
ENSG00000167257	12.59	11.69	12.88	12.96	11.36	12.17	0.0416837123785323	4.70510428062435	0.651712958660064	0.898158427428376	11:117232624-117286445:+	RNF214	1;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 214 [Source:HGNC Symbol%3BAcc:HGNC:25335]
ENSG00000123106	17.65	16.54	19.98	18.14	19.43	18.68	-0.0376192000310697	4.86983736067153	0.651922961115933	0.898262544293939	12:28133248-28581511:+	CCDC91	10;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0042802,molecular_function identical protein binding;GO:0048193,biological_process Golgi vesicle transport;GO:0090160,biological_process Golgi to lysosome transport	NA	coiled-coil domain containing 91 [Source:HGNC Symbol%3BAcc:HGNC:24855]
ENSG00000007541	13.78	15.40	14.83	13.35	15.87	13.97	0.0366169914696585	5.37594961125825	0.65202050145841	0.898262544293939	16:566994-584136:+	PIGQ	10;GO:0000506,cellular_component glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0017176,molecular_function phosphatidylinositol N-acetylglucosaminyltransferase activity	PIGQ, GPI1; phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; K03860	phosphatidylinositol glycan anchor biosynthesis class Q [Source:HGNC Symbol%3BAcc:HGNC:14135]
ENSG00000103222	20.32	19.34	19.94	20.79	19.98	20.56	-0.0284102434359949	6.5552972993297	0.65212299269083	0.898262544293939	16:15949576-16143074:+	ABCC1	28;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006691,biological_process leukotriene metabolic process;GO:0006810,biological_process transport;GO:0006855,biological_process drug transmembrane transport;GO:0008559,molecular_function xenobiotic-transporting ATPase activity;GO:0009235,biological_process cobalamin metabolic process;GO:0015420,molecular_function cobalamin-transporting ATPase activity;GO:0015431,molecular_function glutathione S-conjugate-exporting ATPase activity;GO:0015889,biological_process cobalamin transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0034634,molecular_function glutathione transmembrane transporter activity;GO:0034775,biological_process glutathione transmembrane transport;GO:0035461,biological_process vitamin transmembrane transport;GO:0042493,biological_process response to drug;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042908,biological_process xenobiotic transport;GO:0043225,molecular_function anion transmembrane-transporting ATPase activity;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport	ABCC1; ATP-binding cassette, subfamily C (CFTR/MRP), member 1 [EC:7.6.2.3]; K05665	ATP binding cassette subfamily C member 1 [Source:HGNC Symbol%3BAcc:HGNC:51]
ENSG00000275111	4.94	4.44	4.82	4.90	4.39	5.83	-0.0765706801199747	2.72349795149576	0.652134168257197	0.898262544293939	2:95165431-95184317:+	ZNF2	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 2 [Source:HGNC Symbol%3BAcc:HGNC:12991]
ENSG00000117228	15.27	11.14	13.14	15.18	12.34	13.94	-0.0488572830324318	4.59958579485007	0.652231393471692	0.898262544293939	1:89052318-89065360:-	GBP1	31;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003779,molecular_function actin binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019003,molecular_function GDP binding;GO:0019899,molecular_function enzyme binding;GO:0019955,molecular_function cytokine binding;GO:0030507,molecular_function spectrin binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0050848,biological_process regulation of calcium-mediated signaling;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0051260,biological_process protein homooligomerization;GO:0051607,biological_process defense response to virus;GO:0051879,molecular_function Hsp90 protein binding;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:1900041,biological_process negative regulation of interleukin-2 secretion;GO:1903076,biological_process regulation of protein localization to plasma membrane;GO:1903077,biological_process negative regulation of protein localization to plasma membrane	NA	guanylate binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4182]
ENSG00000007866	8.00	8.03	8.88	9.30	7.65	9.20	-0.0578913700355572	3.56346633199101	0.652291830758314	0.898262544293939	6:35473596-35497076:-	TEAD3	18;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007565,biological_process female pregnancy;GO:0035329,biological_process hippo signaling;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048568,biological_process embryonic organ development;GO:0055059,biological_process asymmetric neuroblast division	TEAD; transcriptional enhancer factor; K09448	TEA domain transcription factor 3 [Source:HGNC Symbol%3BAcc:HGNC:11716]
ENSG00000106460	52.14	57.01	54.42	49.23	61.20	58.82	-0.0396412062800811	5.67297985968387	0.652432417853009	0.898262544293939	7:12211240-12243367:+	TMEM106B	15;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0007040,biological_process lysosome organization;GO:0007041,biological_process lysosomal transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane;GO:0032418,biological_process lysosome localization;GO:0048813,biological_process dendrite morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:1900006,biological_process positive regulation of dendrite development	NA	transmembrane protein 106B [Source:HGNC Symbol%3BAcc:HGNC:22407]
ENSG00000212864	3.25	3.42	2.91	3.73	3.00	3.59	-0.104855771261328	1.4588304342432	0.652457672288677	0.898262544293939	9:137220246-137221581:-	RNF208	6;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination	NA	ring finger protein 208 [Source:HGNC Symbol%3BAcc:HGNC:25420]
ENSG00000173482	52.23	46.99	55.71	54.28	49.81	55.82	-0.0330211372860635	7.90019695100489	0.652492469727786	0.898262544293939	18:7566781-8406861:+	PTPRM	30;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0006470,biological_process protein dephosphorylation;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007165,biological_process signal transduction;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0010842,biological_process retina layer formation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030027,cellular_component lamellipodium;GO:0031175,biological_process neuron projection development;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm	PTPRM; receptor-type tyrosine-protein phosphatase mu [EC:3.1.3.48]; K05693	protein tyrosine phosphatase%2C receptor type M [Source:HGNC Symbol%3BAcc:HGNC:9675]
ENSG00000160401	1.37	0.98	0.97	0.94	1.08	1.05	0.140104299742581	1.01867803238436	0.652547088818883	0.898262544293939	9:127706988-127716002:+	CFAP157	12;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007283,biological_process spermatogenesis;GO:0007288,biological_process sperm axoneme assembly;GO:0008017,molecular_function microtubule binding;GO:0030154,biological_process cell differentiation;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	cilia and flagella associated protein 157 [Source:HGNC Symbol%3BAcc:HGNC:27843]
ENSG00000198690	9.92	8.47	9.21	8.07	9.13	9.86	0.0442516771980577	4.8683697471479	0.652663283848603	0.898262544293939	15:30903851-30943108:+	FAN1	25;GO:0000287,molecular_function magnesium ion binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004528,molecular_function phosphodiesterase I activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0017108,molecular_function 5'-flap endonuclease activity;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0036297,biological_process interstrand cross-link repair;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding;GO:0070336,molecular_function flap-structured DNA binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0140036,Molecular_Function ubiquitin-dependent protein binding	FAN1, MTMR15; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]; K15363	FANCD2 and FANCI associated nuclease 1 [Source:HGNC Symbol%3BAcc:HGNC:29170]
ENSG00000103356	8.66	9.40	9.14	8.06	9.67	10.65	-0.0535014751205921	4.26209957076382	0.652722596776558	0.898262544293939	16:23522013-23557731:-	EARS2	18;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004818,molecular_function glutamate-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006424,biological_process glutamyl-tRNA aminoacylation;GO:0008270,molecular_function zinc ion binding;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0043039,biological_process tRNA aminoacylation;GO:0050561,molecular_function glutamate-tRNA(Gln) ligase activity;GO:0070127,biological_process tRNA aminoacylation for mitochondrial protein translation	EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]; K01885	glutamyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:29419]
ENSG00000160318	1.86	2.66	1.51	2.08	1.33	1.85	0.169126295904415	0.505514160188207	0.652731419435369	0.898262544293939	19:51367097-51369003:-	CLDND2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	claudin domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28511]
ENSG00000171962	2.43	2.39	2.54	1.71	2.66	2.58	0.0964179619803492	2.15236785781596	0.652857588966103	0.898262544293939	17:17972812-18016889:+	DRC3	4;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005930,cellular_component axoneme;GO:0042995,cellular_component cell projection	NA	dynein regulatory complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:25384]
ENSG00000197265	26.16	27.76	27.26	26.36	25.55	27.72	0.0360505900839947	4.64207830038145	0.652930482019401	0.898262544293939	8:30578317-30658251:-	GTF2E2	15;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005673,cellular_component transcription factor TFIIE complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0016607,cellular_component nuclear speck;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	TFIIE2, GTF2E2, TFA2; transcription initiation factor TFIIE subunit beta; K03137	general transcription factor IIE subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:4651]
ENSG00000067066	34.11	30.79	34.83	36.39	30.73	35.97	-0.0346810628926126	6.80116042794689	0.65306820846585	0.898262544293939	2:230415941-230544090:+	SP100	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000723,biological_process telomere maintenance;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0016032,biological_process viral process;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0019900,molecular_function kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030870,cellular_component Mre11 complex;GO:0034340,biological_process response to type I interferon;GO:0034341,biological_process response to interferon-gamma;GO:0042803,molecular_function protein homodimerization activity;GO:0043392,biological_process negative regulation of DNA binding;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045185,biological_process maintenance of protein location;GO:0045765,biological_process regulation of angiogenesis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046826,biological_process negative regulation of protein export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0051271,biological_process negative regulation of cellular component movement;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0070087,molecular_function chromo shadow domain binding;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902044,biological_process regulation of Fas signaling pathway	SP100; nuclear autoantigen Sp-100; K15413	SP100 nuclear antigen [Source:HGNC Symbol%3BAcc:HGNC:11206]
ENSG00000158792	4.30	5.09	4.20	3.70	5.19	4.01	0.0771955907334517	2.56644435614855	0.653108426802868	0.898262544293939	16:89696342-89701705:-	SPATA2L	NA	NA	spermatogenesis associated 2 like [Source:HGNC Symbol%3BAcc:HGNC:28393]
ENSG00000137266	1.78	1.92	1.54	1.76	1.75	1.44	0.0876848920166436	2.06480712886308	0.653112619152328	0.898262544293939	6:3268961-3457022:-	SLC22A23	10;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0015711,biological_process organic anion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 22 member 23 [Source:HGNC Symbol%3BAcc:HGNC:21106]
ENSG00000109083	39.54	40.28	38.57	40.64	35.62	39.81	0.0379750069001795	4.66001803644179	0.653248492557199	0.898262544293939	17:28328324-28335489:-	IFT20	46;GO:0000139,cellular_component Golgi membrane;GO:0001736,biological_process establishment of planar polarity;GO:0001750,cellular_component photoreceptor outer segment;GO:0001822,biological_process kidney development;GO:0002046,molecular_function opsin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0005902,cellular_component microvillus;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0008542,biological_process visual learning;GO:0017137,molecular_function Rab GTPase binding;GO:0022008,biological_process neurogenesis;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0031514,cellular_component motile cilium;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0032420,cellular_component stereocilium;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0035845,biological_process photoreceptor cell outer segment organization;GO:0036064,cellular_component ciliary basal body;GO:0036372,biological_process opsin transport;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0044292,cellular_component dendrite terminus;GO:0051642,biological_process centrosome localization;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0060271,biological_process cilium morphogenesis;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0061351,biological_process neural precursor cell proliferation;GO:0061512,biological_process protein localization to cilium;GO:0070062,cellular_component extracellular exosome;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0090102,biological_process cochlea development;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:1902017,biological_process regulation of cilium assembly;GO:1902636,cellular_component kinociliary basal body;GO:2000785,biological_process regulation of autophagosome assembly	NA	intraflagellar transport 20 [Source:HGNC Symbol%3BAcc:HGNC:30989]
ENSG00000138346	4.06	3.84	3.85	2.75	4.01	4.52	0.0710650427146519	3.72801817900809	0.65329601431517	0.898262544293939	10:68414063-68472121:-	DNA2	46;GO:0000076,biological_process DNA replication checkpoint;GO:0000166,molecular_function nucleotide binding;GO:0000723,biological_process telomere maintenance;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003824,molecular_function catalytic activity;GO:0004386,molecular_function helicase activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005760,cellular_component gamma DNA polymerase complex;GO:0006260,biological_process DNA replication;GO:0006264,biological_process mitochondrial DNA replication;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0016890,molecular_function site-specific endodeoxyribonuclease activity, specific for altered base;GO:0017108,molecular_function 5'-flap endonuclease activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0032508,biological_process DNA duplex unwinding;GO:0033567,biological_process DNA replication, Okazaki fragment processing;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043137,biological_process DNA replication, removal of RNA primer;GO:0043139,molecular_function 5'-3' DNA helicase activity;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0043504,biological_process mitochondrial DNA repair;GO:0044806,biological_process G-quadruplex DNA unwinding;GO:0045740,biological_process positive regulation of DNA replication;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090656,biological_process t-circle formation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902990,biological_process mitotic telomere maintenance via semi-conservative replication	DNA2; DNA replication ATP-dependent helicase Dna2 [EC:3.6.4.12]; K10742	DNA replication helicase/nuclease 2 [Source:HGNC Symbol%3BAcc:HGNC:2939]
ENSG00000198947	0.26	0.30	0.31	0.30	0.29	0.22	0.104861261453198	1.73169522942303	0.653308164817988	0.898262544293939	X:31097676-33339441:-	DMD	100;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002027,biological_process regulation of heart rate;GO:0002162,molecular_function dystroglycan binding;GO:0003779,molecular_function actin binding;GO:0005178,molecular_function integrin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005856,cellular_component cytoskeleton;GO:0005883,cellular_component neurofilament;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007010,biological_process cytoskeleton organization;GO:0007517,biological_process muscle organ development;GO:0007519,biological_process skeletal muscle tissue development;GO:0007568,biological_process aging;GO:0008065,biological_process establishment of blood-nerve barrier;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008307,molecular_function structural constituent of muscle;GO:0009414,biological_process response to water deprivation;GO:0009986,cellular_component cell surface;GO:0010468,biological_process regulation of gene expression;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0014809,biological_process regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0014819,biological_process regulation of skeletal muscle contraction;GO:0014894,biological_process response to denervation involved in regulation of muscle adaptation;GO:0014904,biological_process myotube cell development;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016013,cellular_component syntrophin complex;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0017022,molecular_function myosin binding;GO:0017166,molecular_function vinculin binding;GO:0021629,biological_process olfactory nerve structural organization;GO:0021987,biological_process cerebral cortex development;GO:0030016,cellular_component myofibril;GO:0030018,cellular_component Z disc;GO:0030027,cellular_component lamellipodium;GO:0030049,biological_process muscle filament sliding;GO:0030054,cellular_component cell junction;GO:0030055,cellular_component cell-substrate junction;GO:0030141,cellular_component secretory granule;GO:0030154,biological_process cell differentiation;GO:0030165,molecular_function PDZ domain binding;GO:0030175,cellular_component filopodium;GO:0030182,biological_process neuron differentiation;GO:0030424,cellular_component axon;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031527,cellular_component filopodium membrane;GO:0032403,molecular_function protein complex binding;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034613,biological_process cellular protein localization;GO:0035994,biological_process response to muscle stretch;GO:0042383,cellular_component sarcolemma;GO:0042391,biological_process regulation of membrane potential;GO:0042692,biological_process muscle cell differentiation;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043034,cellular_component costamere;GO:0043043,biological_process peptide biosynthetic process;GO:0043234,cellular_component protein complex;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0043623,biological_process cellular protein complex assembly;GO:0044306,cellular_component neuron projection terminus;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045213,biological_process neurotransmitter receptor metabolic process;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048747,biological_process muscle fiber development;GO:0048812,biological_process neuron projection morphogenesis;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0051647,biological_process nucleus localization;GO:0051726,biological_process regulation of cell cycle;GO:0060048,biological_process cardiac muscle contraction;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0060857,biological_process establishment of glial blood-brain barrier;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0086001,biological_process cardiac muscle cell action potential;GO:0090287,biological_process regulation of cellular response to growth factor stimulus;GO:0097449,cellular_component astrocyte projection;GO:0099617,cellular_component matrix side of mitochondrial inner membrane;GO:1901385,biological_process regulation of voltage-gated calcium channel activity;GO:1902083,biological_process negative regulation of peptidyl-cysteine S-nitrosylation;GO:2000651,biological_process positive regulation of sodium ion transmembrane transporter activity	DMD; dystrophin; K10366	dystrophin [Source:HGNC Symbol%3BAcc:HGNC:2928]
ENSG00000099194	2492.63	2724.99	2540.57	2680.93	2730.82	2562.92	-0.0279892569630332	11.4646289259023	0.653506969413944	0.898314606235143	10:100347123-100364834:+	SCD	18;GO:0004768,molecular_function stearoyl-CoA 9-desaturase activity;GO:0005506,molecular_function iron ion binding;GO:0005730,cellular_component nucleolus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016717,molecular_function oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0055114,biological_process oxidation-reduction process;GO:1903966,biological_process monounsaturated fatty acid biosynthetic process	SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]; K00507	stearoyl-CoA desaturase [Source:HGNC Symbol%3BAcc:HGNC:10571]
ENSG00000237172	3.16	1.82	2.32	1.61	2.20	2.97	0.13210836805392	1.59601547192763	0.653613216213492	0.898314606235143	16:67148104-67151214:-	B3GNT9	9;GO:0000139,cellular_component Golgi membrane;GO:0001650,cellular_component fibrillar center;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase 9 [Source:HGNC Symbol%3BAcc:HGNC:28714]
ENSG00000089159	21.99	23.01	23.99	24.80	20.38	22.69	0.0349658078128349	6.36850502821664	0.653643944090823	0.898314606235143	12:120210438-120265771:-	PXN	29;GO:0001725,cellular_component stress fiber;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006936,biological_process muscle contraction;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007165,biological_process signal transduction;GO:0007172,biological_process signal complex assembly;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008013,molecular_function beta-catenin binding;GO:0017166,molecular_function vinculin binding;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0060396,biological_process growth hormone receptor signaling pathway;GO:1901652,biological_process response to peptide	PXN; paxillin; K05760	paxillin [Source:HGNC Symbol%3BAcc:HGNC:9718]
ENSG00000132305	57.73	60.46	52.27	59.44	58.56	57.54	-0.0319165751043642	7.05019411224753	0.653656728945567	0.898314606235143	2:86143931-86195770:-	IMMT	11;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042407,biological_process cristae formation;GO:0043209,cellular_component myelin sheath;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0061617,cellular_component MICOS complex	NA	inner membrane mitochondrial protein [Source:HGNC Symbol%3BAcc:HGNC:6047]
ENSG00000079785	78.87	82.87	73.90	75.78	77.67	79.28	0.0286279966455566	7.44920345806643	0.653707873851772	0.898314606235143	2:15591177-15631111:+	DDX1	43;GO:0000166,molecular_function nucleotide binding;GO:0000245,biological_process spliceosomal complex assembly;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0003725,molecular_function double-stranded RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006302,biological_process double-strand break repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0006446,biological_process regulation of translational initiation;GO:0007275,biological_process multicellular organism development;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0008033,biological_process tRNA processing;GO:0008143,molecular_function poly(A) binding;GO:0009615,biological_process response to virus;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032508,biological_process DNA duplex unwinding;GO:0033677,molecular_function DNA/RNA helicase activity;GO:0043330,biological_process response to exogenous dsRNA;GO:0071920,cellular_component cleavage body;GO:0072669,cellular_component tRNA-splicing ligase complex;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1903608,biological_process protein localization to cytoplasmic stress granule	NA	DEAD-box helicase 1 [Source:HGNC Symbol%3BAcc:HGNC:2734]
ENSG00000065150	36.17	34.83	35.47	35.07	32.83	37.25	0.0298892132728762	7.00636986350573	0.653831631232137	0.898340356371376	13:97953657-98024297:+	IPO5	24;GO:0000060,biological_process protein import into nucleus, translocation;GO:0003723,molecular_function RNA binding;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0031965,cellular_component nuclear membrane;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034399,cellular_component nuclear periphery;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0071230,biological_process cellular response to amino acid stimulus	NA	importin 5 [Source:HGNC Symbol%3BAcc:HGNC:6402]
ENSG00000112584	18.00	18.07	16.06	18.52	18.52	16.77	-0.035146595438769	5.63898037189905	0.653871354210536	0.898340356371376	6:170290702-170407065:+	FAM120B	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0035357,biological_process peroxisome proliferator activated receptor signaling pathway;GO:0045444,biological_process fat cell differentiation	NA	family with sequence similarity 120B [Source:HGNC Symbol%3BAcc:HGNC:21109]
ENSG00000137628	5.07	4.07	5.03	4.33	4.63	4.93	0.049059973982613	4.61639436616665	0.653984034598044	0.898395730573873	4:168216292-168318807:-	DDX60	19;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0009615,biological_process response to virus;GO:0016787,molecular_function hydrolase activity;GO:0045087,biological_process innate immune response;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051607,biological_process defense response to virus;GO:1900245,biological_process positive regulation of MDA-5 signaling pathway;GO:1900246,biological_process positive regulation of RIG-I signaling pathway	NA	DExD/H-box helicase 60 [Source:HGNC Symbol%3BAcc:HGNC:25942]
ENSG00000163155	17.24	16.13	15.19	17.65	18.83	14.61	-0.0580528117232715	3.59250763062081	0.654135928918524	0.898504955811181	1:151159747-151165948:-	LYSMD1	1;GO:0005515,molecular_function protein binding	NA	LysM domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:32070]
ENSG00000156411	122.03	123.64	113.98	129.21	118.10	123.02	-0.0321406796301482	5.82021509100085	0.654291370465278	0.898619028721565	14:103912287-103928269:-	C14orf2	8;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane	NA	chromosome 14 open reading frame 2 [Source:HGNC Symbol%3BAcc:HGNC:1188]
ENSG00000175701	26.44	28.16	27.02	20.26	29.49	28.87	0.0624737802056584	3.48569983087279	0.654410213758713	0.898682817057961	2:110211528-110245420:-	LINC00116	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	long intergenic non-protein coding RNA 116 [Source:HGNC Symbol%3BAcc:HGNC:27339]
ENSG00000154556	0.40	0.69	0.67	0.63	0.67	0.61	-0.129955546814684	1.59926383855013	0.654622113063385	0.898857873881617	4:185585443-185956652:-	SORBS2	23;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008150,biological_process biological_process;GO:0008307,molecular_function structural constituent of muscle;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0030018,cellular_component Z disc;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0042995,cellular_component cell projection;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061049,biological_process cell growth involved in cardiac muscle cell development	NA	sorbin and SH3 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24098]
ENSG00000163104	15.93	16.02	15.16	16.72	16.67	15.18	-0.03238732878593	5.64649462512656	0.654734903019544	0.898857873881617	4:94207610-94291292:+	SMARCAD1	28;GO:0000018,biological_process regulation of DNA recombination;GO:0000166,molecular_function nucleotide binding;GO:0000729,biological_process DNA double-strand break processing;GO:0000792,cellular_component heterochromatin;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009117,biological_process nucleotide metabolic process;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0035861,cellular_component site of double-strand break;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043596,cellular_component nuclear replication fork;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051260,biological_process protein homooligomerization;GO:0051304,biological_process chromosome separation;GO:0070932,biological_process histone H3 deacetylation;GO:0070933,biological_process histone H4 deacetylation	SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 [EC:3.6.4.12]; K14439	SWI/SNF-related%2C matrix-associated actin-dependent regulator of chromatin%2C subfamily a%2C containing DEAD/H box 1 [Source:HGNC Symbol%3BAcc:HGNC:18398]
ENSG00000068001	10.70	15.69	12.71	12.82	13.31	11.60	0.0535112497033927	4.18668720792703	0.654754925935517	0.898857873881617	3:50317789-50322906:-	HYAL2	67;GO:0000139,cellular_component Golgi membrane;GO:0000302,biological_process response to reactive oxygen species;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001618,molecular_function virus receptor activity;GO:0001822,biological_process kidney development;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003824,molecular_function catalytic activity;GO:0004415,molecular_function hyalurononglucosaminidase activity;GO:0005515,molecular_function protein binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008152,biological_process metabolic process;GO:0009615,biological_process response to virus;GO:0009986,cellular_component cell surface;GO:0010259,biological_process multicellular organism aging;GO:0010764,biological_process negative regulation of fibroblast migration;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019064,biological_process fusion of virus membrane with host plasma membrane;GO:0019087,biological_process transformation of host cell by virus;GO:0019899,molecular_function enzyme binding;GO:0030139,cellular_component endocytic vesicle;GO:0030214,biological_process hyaluronan catabolic process;GO:0030294,molecular_function receptor signaling protein tyrosine kinase inhibitor activity;GO:0030308,biological_process negative regulation of cell growth;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031225,cellular_component anchored component of membrane;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033906,molecular_function hyaluronoglucuronidase activity;GO:0035810,biological_process positive regulation of urine volume;GO:0042117,biological_process monocyte activation;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045121,cellular_component membrane raft;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046658,cellular_component anchored component of plasma membrane;GO:0046677,biological_process response to antibiotic;GO:0046718,biological_process viral entry into host cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048705,biological_process skeletal system morphogenesis;GO:0050431,molecular_function transforming growth factor beta binding;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051216,biological_process cartilage development;GO:0051607,biological_process defense response to virus;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060586,biological_process multicellular organismal iron ion homeostasis;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity;GO:0070295,biological_process renal water absorption;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071493,biological_process cellular response to UV-B;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:2000484,biological_process positive regulation of interleukin-8 secretion;GO:2000778,biological_process positive regulation of interleukin-6 secretion;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	hya; hyaluronoglucosaminidase [EC:3.2.1.35]; K01197	hyaluronoglucosaminidase 2 [Source:HGNC Symbol%3BAcc:HGNC:5321]
ENSG00000107593	0.17	0.43	0.30	0.18	0.40	0.49	-0.292692805534879	-0.0735629989300625	0.654874209866457	0.898922212437503	10:100288153-100330486:-	PKD2L1	39;GO:0001581,biological_process detection of chemical stimulus involved in sensory perception of sour taste;GO:0005227,molecular_function calcium activated cation channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006816,biological_process calcium ion transport;GO:0007224,biological_process smoothened signaling pathway;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0009986,cellular_component cell surface;GO:0015269,molecular_function calcium-activated potassium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033040,molecular_function sour taste receptor activity;GO:0034703,cellular_component cation channel complex;GO:0034704,cellular_component calcium channel complex;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043235,cellular_component receptor complex;GO:0050915,biological_process sensory perception of sour taste;GO:0050982,biological_process detection of mechanical stimulus;GO:0051371,molecular_function muscle alpha-actinin binding;GO:0051393,molecular_function alpha-actinin binding;GO:0060170,cellular_component ciliary membrane;GO:0070207,biological_process protein homotrimerization;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071468,biological_process cellular response to acidic pH;GO:0071805,biological_process potassium ion transmembrane transport;GO:0097730,cellular_component non-motile cilium	PKD2L1; polycystin 2L1; K04990	polycystin 2 like 1%2C transient receptor potential cation channel [Source:HGNC Symbol%3BAcc:HGNC:9011]
ENSG00000204248	0.40	0.34	0.38	0.43	0.33	0.28	0.139705380434993	1.03711840310223	0.655084835761473	0.899111904722155	6:33162680-33192499:-	COL11A2	22;GO:0001501,biological_process skeletal system development;GO:0001649,biological_process osteoblast differentiation;GO:0001894,biological_process tissue homeostasis;GO:0002062,biological_process chondrocyte differentiation;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005592,cellular_component collagen type XI trimer;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005840,cellular_component ribosome;GO:0007605,biological_process sensory perception of sound;GO:0030020,molecular_function extracellular matrix structural constituent conferring tensile strength;GO:0030199,biological_process collagen fibril organization;GO:0030574,biological_process collagen catabolic process;GO:0030674,molecular_function protein binding, bridging;GO:0046872,molecular_function metal ion binding;GO:0048705,biological_process skeletal system morphogenesis;GO:0051216,biological_process cartilage development;GO:0060021,biological_process palate development;GO:0060023,biological_process soft palate development	COL1A; collagen, type I, alpha; K06236	collagen type XI alpha 2 chain [Source:HGNC Symbol%3BAcc:HGNC:2187]
ENSG00000004478	65.52	71.06	65.23	65.91	71.50	70.27	-0.0314394306764424	6.70013384512275	0.655390235569623	0.899431619029932	12:2794952-2805423:+	FKBP4	43;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005528,molecular_function FK506 binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0006463,biological_process steroid hormone receptor complex assembly;GO:0006825,biological_process copper ion transport;GO:0007566,biological_process embryo implantation;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016853,molecular_function isomerase activity;GO:0030424,cellular_component axon;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030674,molecular_function protein binding, bridging;GO:0030850,biological_process prostate gland development;GO:0031072,molecular_function heat shock protein binding;GO:0031111,biological_process negative regulation of microtubule polymerization or depolymerization;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0031503,biological_process protein complex localization;GO:0032767,molecular_function copper-dependent protein binding;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0044295,cellular_component axonal growth cone;GO:0046661,biological_process male sex differentiation;GO:0048156,molecular_function tau protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048608,biological_process reproductive structure development;GO:0051219,molecular_function phosphoprotein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:1900034,biological_process regulation of cellular response to heat	FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]; K09571	FK506 binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:3720]
ENSG00000137337	13.00	14.53	12.57	14.13	14.57	12.69	-0.0360813099576442	6.41360545206001	0.655562769590121	0.899511119890293	6:30699806-30717889:-	MDC1	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005925,cellular_component focal adhesion;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0016604,cellular_component nuclear body;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0070975,molecular_function FHA domain binding	NA	mediator of DNA damage checkpoint 1 [Source:HGNC Symbol%3BAcc:HGNC:21163]
ENSG00000075089	29.63	27.03	25.77	26.87	29.86	28.51	-0.0350657913323357	5.24916807543042	0.655593096080519	0.899511119890293	12:100199121-100241865:+	ACTR6	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006338,biological_process chromatin remodeling	NA	ARP6 actin related protein 6 homolog [Source:HGNC Symbol%3BAcc:HGNC:24025]
ENSG00000032219	10.76	10.31	9.69	10.00	9.43	10.83	0.0348262625062894	5.26886613684144	0.655773214834372	0.899601538873719	14:58298384-58373887:+	ARID4A	23;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0016575,biological_process histone deacetylation;GO:0017053,cellular_component transcriptional repressor complex;GO:0034773,biological_process histone H4-K20 trimethylation;GO:0036124,biological_process histone H3-K9 trimethylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048821,biological_process erythrocyte development;GO:0080182,biological_process histone H3-K4 trimethylation;GO:0097368,biological_process establishment of Sertoli cell barrier	NA	AT-rich interaction domain 4A [Source:HGNC Symbol%3BAcc:HGNC:9885]
ENSG00000140511	0.88	1.96	1.45	1.37	1.94	1.39	-0.152343342626584	1.116818527942	0.655803941453982	0.899601538873719	15:88877287-88895626:-	HAPLN3	8;GO:0001501,biological_process skeletal system development;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005540,molecular_function hyaluronic acid binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0007155,biological_process cell adhesion;GO:0007417,biological_process central nervous system development	NA	hyaluronan and proteoglycan link protein 3 [Source:HGNC Symbol%3BAcc:HGNC:21446]
ENSG00000169908	361.64	380.27	335.48	370.91	370.63	366.45	-0.029419056161538	7.93675484641776	0.655925470173895	0.899668824449565	3:149369021-149377865:-	TM4SF1	5;GO:0003674,molecular_function molecular_function;GO:0005887,cellular_component integral component of plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane 4 L six family member 1 [Source:HGNC Symbol%3BAcc:HGNC:11853]
ENSG00000173914	14.56	15.85	17.52	16.47	18.63	14.98	-0.0506533639943787	4.2604924715244	0.656056790452003	0.899749523796344	11:66664997-66677921:-	RBM4B	16;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0006417,biological_process regulation of translation;GO:0007623,biological_process circadian rhythm;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0010628,biological_process positive regulation of gene expression;GO:0032922,biological_process circadian regulation of gene expression;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0046872,molecular_function metal ion binding	NA	RNA binding motif protein 4B [Source:HGNC Symbol%3BAcc:HGNC:28842]
ENSG00000111412	9.76	13.67	8.38	9.98	11.72	8.23	0.0853376206893307	2.67881370436131	0.656243097335894	0.899873516438191	12:116710184-116738070:-	C12orf49	2;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region	NA	chromosome 12 open reading frame 49 [Source:HGNC Symbol%3BAcc:HGNC:26128]
ENSG00000175592	104.42	90.51	106.55	121.66	82.47	110.88	-0.0504998048769572	6.38975570800691	0.656292189181901	0.899873516438191	11:65892048-65900573:-	FOSL1	41;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006935,biological_process chemotaxis;GO:0006968,biological_process cellular defense response;GO:0007296,biological_process vitellogenesis;GO:0007565,biological_process female pregnancy;GO:0007612,biological_process learning;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009612,biological_process response to mechanical stimulus;GO:0009615,biological_process response to virus;GO:0009629,biological_process response to gravity;GO:0014070,biological_process response to organic cyclic compound;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0032570,biological_process response to progesterone;GO:0034097,biological_process response to cytokine;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042734,cellular_component presynaptic membrane;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045787,biological_process positive regulation of cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051412,biological_process response to corticosterone;GO:0051591,biological_process response to cAMP;GO:0060674,biological_process placenta blood vessel development;GO:0061614,biological_process pri-miRNA transcription from RNA polymerase II promoter;GO:2000144,biological_process positive regulation of DNA-templated transcription, initiation	FOSL1; fos-like antigen 1; K04502	FOS like 1%2C AP-1 transcription factor subunit [Source:HGNC Symbol%3BAcc:HGNC:13718]
ENSG00000112031	20.03	16.75	16.54	19.09	18.25	18.15	-0.0406115362256226	4.52160395494337	0.656465959927177	0.900012365868793	6:152987361-153002685:-	MTRF1L	6;GO:0003747,molecular_function translation release factor activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006415,biological_process translational termination;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial translational release factor 1 like [Source:HGNC Symbol%3BAcc:HGNC:21051]
ENSG00000139433	15.91	16.79	19.67	15.51	17.99	17.32	0.0564993871010492	3.53800709781022	0.656613126675552	0.900104683947587	12:109850942-109880488:-	GLTP	14;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0017089,molecular_function glycolipid transporter activity;GO:0046836,biological_process glycolipid transport;GO:0051861,molecular_function glycolipid binding;GO:0070062,cellular_component extracellular exosome;GO:0120009,biological_process intermembrane lipid transfer;GO:0120013,molecular_function intermembrane lipid transfer activity	NA	glycolipid transfer protein [Source:HGNC Symbol%3BAcc:HGNC:24867]
ENSG00000169213	2.69	3.78	2.58	3.19	2.42	2.57	0.129528969082801	1.0113432943393	0.656834517312267	0.900104683947587	1:51907955-51990764:-	RAB3B	23;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008021,cellular_component synaptic vesicle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017157,biological_process regulation of exocytosis;GO:0018125,biological_process peptidyl-cysteine methylation;GO:0019003,molecular_function GDP binding;GO:0019882,biological_process antigen processing and presentation;GO:0030141,cellular_component secretory granule;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031489,molecular_function myosin V binding;GO:0031982,cellular_component vesicle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051586,biological_process positive regulation of dopamine uptake involved in synaptic transmission;GO:0070062,cellular_component extracellular exosome;GO:0097494,biological_process regulation of vesicle size	NA	RAB3B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9778]
ENSG00000163050	7.20	6.45	7.20	7.17	6.45	6.74	0.0532315344821656	3.75682542139147	0.656869257266308	0.900104683947587	1:226897535-226987545:+	COQ8A	11;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043531,molecular_function ADP binding	NA	coenzyme Q8A [Source:HGNC Symbol%3BAcc:HGNC:16812]
ENSG00000159685	11.41	13.23	11.70	13.25	10.31	11.45	0.0575412801998422	3.23237906640241	0.656896392008675	0.900104683947587	3:126704219-126960406:+	CHCHD6	8;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016020,cellular_component membrane;GO:0042407,biological_process cristae formation;GO:0061617,cellular_component MICOS complex	NA	coiled-coil-helix-coiled-coil-helix domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:28184]
ENSG00000014641	170.96	179.56	152.66	166.12	188.79	164.67	-0.0352952647982338	7.50573066174801	0.656929089055997	0.900104683947587	2:63588608-63607197:+	MDH1	24;GO:0003824,molecular_function catalytic activity;GO:0004470,molecular_function malic enzyme activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006108,biological_process malate metabolic process;GO:0006734,biological_process NADH metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016615,molecular_function malate dehydrogenase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019674,biological_process NAD metabolic process;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030060,molecular_function L-malate dehydrogenase activity;GO:0043209,cellular_component myelin sheath;GO:0047860,molecular_function diiodophenylpyruvate reductase activity;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	MDH1; malate dehydrogenase [EC:1.1.1.37]; K00025	malate dehydrogenase 1 [Source:HGNC Symbol%3BAcc:HGNC:6970]
ENSG00000142552	1.65	1.40	1.15	1.09	1.26	1.44	0.157210226142245	0.603986184237205	0.657032118794486	0.900104683947587	19:49527617-49546962:+	RCN3	5;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0046872,molecular_function metal ion binding	NA	reticulocalbin 3 [Source:HGNC Symbol%3BAcc:HGNC:21145]
ENSG00000113328	146.52	166.93	145.59	138.09	164.16	149.12	0.0347483980592224	7.11396418841443	0.657159085896058	0.900104683947587	5:163437568-163446151:+	CCNG1	7;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	CCNG1; cyclin G1; K10145	cyclin G1 [Source:HGNC Symbol%3BAcc:HGNC:1592]
ENSG00000101997	9.01	9.81	8.33	8.40	8.95	10.95	-0.0553135809496494	4.13204733147268	0.657161404504412	0.900104683947587	X:49235466-49250526:+	CCDC22	16;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0007253,biological_process cytoplasmic sequestering of NF-kappaB;GO:0015031,biological_process protein transport;GO:0016567,biological_process protein ubiquitination;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043687,biological_process post-translational protein modification;GO:0097602,molecular_function cullin family protein binding;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	coiled-coil domain containing 22 [Source:HGNC Symbol%3BAcc:HGNC:28909]
ENSG00000172476	2.38	2.65	2.57	2.52	2.19	2.28	0.123216963301504	1.11548110116122	0.657237068271372	0.900104683947587	X:103499129-103519489:-	RAB40A	11;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0030667,cellular_component secretory granule membrane;GO:0035556,biological_process intracellular signal transduction;GO:0072659,biological_process protein localization to plasma membrane	NA	RAB40A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:18283]
ENSG00000159377	236.76	236.86	231.30	231.33	238.16	228.18	0.0265866891872416	7.53452106280875	0.657373827981738	0.900104683947587	1:151399533-151401944:+	PSMB4	42;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0001530,molecular_function lipopolysaccharide binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002862,biological_process negative regulation of inflammatory response to antigenic stimulus;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMB4; 20S proteasome subunit beta 7 [EC:3.4.25.1]; K02736	proteasome subunit beta 4 [Source:HGNC Symbol%3BAcc:HGNC:9541]
ENSG00000165633	5.58	5.77	5.13	5.64	5.71	4.44	0.0728170644972061	2.56580681185388	0.657416908968531	0.900104683947587	10:49014244-49115509:-	VSTM4	4;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	V-set and transmembrane domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:26470]
ENSG00000149021	7.24	9.80	7.28	9.87	10.28	6.44	-0.130764482799632	1.29099170186061	0.657471221866762	0.900104683947587	11:62405102-62423195:+	SCGB1A1	33;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0007165,biological_process signal transduction;GO:0007565,biological_process female pregnancy;GO:0007566,biological_process embryo implantation;GO:0009410,biological_process response to xenobiotic stimulus;GO:0010033,biological_process response to organic substance;GO:0010193,biological_process response to ozone;GO:0019834,molecular_function phospholipase A2 inhibitor activity;GO:0030141,cellular_component secretory granule;GO:0032496,biological_process response to lipopolysaccharide;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032696,biological_process negative regulation of interleukin-13 production;GO:0032713,biological_process negative regulation of interleukin-4 production;GO:0032714,biological_process negative regulation of interleukin-5 production;GO:0034021,biological_process response to silicon dioxide;GO:0034097,biological_process response to cytokine;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042493,biological_process response to drug;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043488,biological_process regulation of mRNA stability;GO:0050727,biological_process regulation of inflammatory response;GO:0051384,biological_process response to glucocorticoid;GO:0070062,cellular_component extracellular exosome;GO:0071774,biological_process response to fibroblast growth factor;GO:0097160,molecular_function polychlorinated biphenyl binding	NA	secretoglobin family 1A member 1 [Source:HGNC Symbol%3BAcc:HGNC:12523]
ENSG00000122705	163.59	171.37	149.96	151.04	171.67	155.11	0.0323079008924141	7.38430395919094	0.657499746085097	0.900104683947587	9:36190855-36304781:+	CLTA	37;GO:0003674,molecular_function molecular_function;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030118,cellular_component clathrin coat;GO:0030125,cellular_component clathrin vesicle coat;GO:0030130,cellular_component clathrin coat of trans-Golgi network vesicle;GO:0030132,cellular_component clathrin coat of coated pit;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032050,molecular_function clathrin heavy chain binding;GO:0032403,molecular_function protein complex binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0036020,cellular_component endolysosome membrane;GO:0042277,molecular_function peptide binding;GO:0048268,biological_process clathrin coat assembly;GO:0051020,molecular_function GTPase binding;GO:0051301,biological_process cell division;GO:0061024,biological_process membrane organization;GO:0071439,cellular_component clathrin complex;GO:0072583,biological_process clathrin-mediated endocytosis	CLTA, LCA; clathrin light chain A; K04644	clathrin light chain A [Source:HGNC Symbol%3BAcc:HGNC:2090]
ENSG00000153395	125.91	138.70	116.60	124.79	132.18	136.03	-0.0332416154777182	7.69287171142518	0.65762147496578	0.900104683947587	5:1456479-1523977:-	LPCAT1	32;GO:0000139,cellular_component Golgi membrane;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0035577,cellular_component azurophil granule membrane;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0043129,biological_process surfactant homeostasis;GO:0043312,biological_process neutrophil degranulation;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047159,molecular_function 1-alkenylglycerophosphocholine O-acyltransferase activity;GO:0047184,molecular_function 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047191,molecular_function 1-alkylglycerophosphocholine O-acyltransferase activity;GO:0047192,molecular_function 1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0060041,biological_process retina development in camera-type eye;GO:2001246,biological_process negative regulation of phosphatidylcholine biosynthetic process	LPCAT1_2; lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]; K13510	lysophosphatidylcholine acyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:25718]
ENSG00000069702	0.98	1.15	1.47	1.04	1.25	1.61	-0.110480825424104	1.80502877482179	0.657671146772884	0.900104683947587	1:91680342-91906335:-	TGFBR3	63;GO:0001666,biological_process response to hypoxia;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001889,biological_process liver development;GO:0003007,biological_process heart morphogenesis;GO:0003150,biological_process muscular septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003223,biological_process ventricular compact myocardium morphogenesis;GO:0005024,molecular_function transforming growth factor beta-activated receptor activity;GO:0005114,molecular_function type II transforming growth factor beta receptor binding;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006955,biological_process immune response;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007181,biological_process transforming growth factor beta receptor complex assembly;GO:0008201,molecular_function heparin binding;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0016477,biological_process cell migration;GO:0017134,molecular_function fibroblast growth factor binding;GO:0030165,molecular_function PDZ domain binding;GO:0030509,biological_process BMP signaling pathway;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031100,biological_process organ regeneration;GO:0032354,biological_process response to follicle-stimulating hormone;GO:0034673,cellular_component inhibin-betaglycan-ActRII complex;GO:0034695,biological_process response to prostaglandin E;GO:0034699,biological_process response to luteinizing hormone;GO:0035556,biological_process intracellular signal transduction;GO:0043235,cellular_component receptor complex;GO:0043393,biological_process regulation of protein binding;GO:0046332,molecular_function SMAD binding;GO:0048185,molecular_function activin binding;GO:0050431,molecular_function transforming growth factor beta binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051271,biological_process negative regulation of cellular component movement;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0060021,biological_process palate development;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060216,biological_process definitive hemopoiesis;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0060318,biological_process definitive erythrocyte differentiation;GO:0060347,biological_process heart trabecula formation;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060939,biological_process epicardium-derived cardiac fibroblast cell development;GO:0060979,biological_process vasculogenesis involved in coronary vascular morphogenesis;GO:0061384,biological_process heart trabecula morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070123,molecular_function transforming growth factor beta receptor activity, type III	NA	transforming growth factor beta receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:11774]
ENSG00000174007	6.04	8.90	5.04	6.41	5.62	6.42	0.0977365071269202	1.7975514877288	0.658106075790141	0.900104683947587	3:196706276-196712293:-	CEP19	8;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection	NA	centrosomal protein 19 [Source:HGNC Symbol%3BAcc:HGNC:28209]
ENSG00000121318	0.69	1.14	1.28	0.65	0.91	1.07	0.23221694576865	0.0374066785115209	0.658305128289859	0.900104683947587	12:10825316-10826358:-	TAS2R10	12;GO:0001580,biological_process detection of chemical stimulus involved in sensory perception of bitter taste;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008527,molecular_function taste receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033038,molecular_function bitter taste receptor activity;GO:0050896,biological_process response to stimulus;GO:0050909,biological_process sensory perception of taste	TAS2R; taste receptor type 2; K08474	taste 2 receptor member 10 [Source:HGNC Symbol%3BAcc:HGNC:14918]
ENSG00000166435	4.94	3.58	4.69	4.87	3.82	4.10	0.0717210068330722	3.40871585224923	0.658350074122609	0.900104683947587	11:74807738-74949200:-	XRRA1	6;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0010165,biological_process response to X-ray;GO:0016604,cellular_component nuclear body	NA	X-ray radiation resistance associated 1 [Source:HGNC Symbol%3BAcc:HGNC:18868]
ENSG00000053372	52.11	51.18	52.97	55.24	53.42	52.47	-0.0310369607802987	5.25231273423036	0.658366050491913	0.900104683947587	1:19251538-19260128:+	MRTO4	10;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0042254,biological_process ribosome biogenesis	NA	MRT4 homolog%2C ribosome maturation factor [Source:HGNC Symbol%3BAcc:HGNC:18477]
ENSG00000170445	31.71	36.15	33.14	33.81	36.58	33.69	-0.0352134806041099	5.71010892405573	0.658428955582298	0.900104683947587	5:140673172-140692024:-	HARS	12;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004821,molecular_function histidine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006427,biological_process histidyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity;GO:0032543,biological_process mitochondrial translation	HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]; K01892	histidyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:4816]
ENSG00000185049	17.37	16.74	19.84	17.78	17.33	20.88	-0.0400269523388857	5.28738074309181	0.658471313520829	0.900104683947587	4:1982713-2041903:-	NELFA	16;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0016604,cellular_component nuclear body;GO:0032021,cellular_component NELF complex;GO:0034244,biological_process negative regulation of transcription elongation from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050434,biological_process positive regulation of viral transcription;GO:0051571,biological_process positive regulation of histone H3-K4 methylation	NA	negative elongation factor complex member A [Source:HGNC Symbol%3BAcc:HGNC:12768]
ENSG00000124383	18.20	18.38	16.61	18.13	17.98	18.70	-0.0341382467560948	5.30602280741227	0.65861676355126	0.900104683947587	2:71130313-71150101:+	MPHOSPH10	17;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0008380,biological_process RNA splicing;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032040,cellular_component small-subunit processome;GO:0034457,cellular_component Mpp10 complex;GO:0042254,biological_process ribosome biogenesis	MPP10; U3 small nucleolar RNA-associated protein MPP10; K14559	M-phase phosphoprotein 10 [Source:HGNC Symbol%3BAcc:HGNC:7213]
ENSG00000134186	41.43	37.94	42.24	41.29	40.40	43.64	-0.029259433131496	6.0910661864556	0.658638282085109	0.900104683947587	1:108692322-108701803:+	PRPF38B	6;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0071011,cellular_component precatalytic spliceosome	PRPF38B; pre-mRNA-splicing factor 38B; K12850	pre-mRNA processing factor 38B [Source:HGNC Symbol%3BAcc:HGNC:25512]
ENSG00000174827	234.51	251.28	224.82	213.51	264.16	220.75	0.0364740848398257	8.51562473583689	0.65864909960305	0.900104683947587	1:145670851-145708148:-	PDZK1	19;GO:0005124,molecular_function scavenger receptor binding;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008283,biological_process cell proliferation;GO:0015879,biological_process carnitine transport;GO:0015893,biological_process drug transport;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030165,molecular_function PDZ domain binding;GO:0031526,cellular_component brush border membrane;GO:0031528,cellular_component microvillus membrane;GO:0032403,molecular_function protein complex binding;GO:0034767,biological_process positive regulation of ion transmembrane transport;GO:0044070,biological_process regulation of anion transport;GO:0045121,cellular_component membrane raft;GO:0070062,cellular_component extracellular exosome;GO:0090314,biological_process positive regulation of protein targeting to membrane	NA	PDZ domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:8821]
ENSG00000042429	3.67	3.09	3.16	2.55	3.49	3.50	0.0734556040152159	2.9628468524079	0.658657663578706	0.900104683947587	11:93784226-93814963:+	MED17	21;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016592,cellular_component mediator complex;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding	MED17; mediator of RNA polymerase II transcription subunit 17; K15133	mediator complex subunit 17 [Source:HGNC Symbol%3BAcc:HGNC:2375]
ENSG00000104756	22.55	20.70	21.36	22.69	21.82	22.40	-0.0350131509633887	4.68933195458154	0.658668480675609	0.900104683947587	8:25427846-25458476:-	KCTD9	8;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0043621,molecular_function protein self-association;GO:0051260,biological_process protein homooligomerization;GO:0097602,molecular_function cullin family protein binding	NA	potassium channel tetramerization domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:22401]
ENSG00000279767	47.92	52.11	59.23	47.42	56.16	51.90	0.0468405167151551	4.47185576447738	0.658722568492563	0.900104683947587	1:153772370-153774079:-	AL513523.10	NA	NA	NA
ENSG00000114744	47.26	48.49	43.73	45.58	51.86	46.74	-0.0382708157991254	5.01319112004115	0.658896465451274	0.900104683947587	3:149738469-149752499:-	COMMD2	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	COMM domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24993]
ENSG00000064989	1.33	1.52	0.48	0.70	1.15	1.07	0.170543979710607	0.652412861386557	0.65902441707489	0.900104683947587	2:187343128-187448460:-	CALCRL	32;GO:0001525,biological_process angiogenesis;GO:0001605,molecular_function adrenomedullin receptor activity;GO:0001635,molecular_function calcitonin gene-related peptide receptor activity;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004948,molecular_function calcitonin receptor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006171,biological_process cAMP biosynthetic process;GO:0006816,biological_process calcium ion transport;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007187,biological_process G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007507,biological_process heart development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031623,biological_process receptor internalization;GO:0045986,biological_process negative regulation of smooth muscle contraction;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050728,biological_process negative regulation of inflammatory response;GO:0071329,biological_process cellular response to sucrose stimulus	CALCRL; calcitonin receptor-like; K04577	calcitonin receptor like receptor [Source:HGNC Symbol%3BAcc:HGNC:16709]
ENSG00000177853	6.45	5.58	6.93	6.16	6.49	7.07	-0.0389842114603698	4.85464772562194	0.659030975867257	0.900104683947587	10:96129714-96205288:+	ZNF518A	9;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 518A [Source:HGNC Symbol%3BAcc:HGNC:29009]
ENSG00000141084	7.69	7.81	7.62	7.23	8.07	7.28	0.0453627567970212	3.95675103837927	0.659163350621311	0.900104683947587	16:67723065-67806652:-	RANBP10	3;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	RAN binding protein 10 [Source:HGNC Symbol%3BAcc:HGNC:29285]
ENSG00000152078	10.47	8.48	8.49	8.07	10.67	7.58	0.0814493366125953	2.85436314161755	0.659209050820703	0.900104683947587	1:95117337-95197607:+	TMEM56	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 56 [Source:HGNC Symbol%3BAcc:HGNC:26477]
ENSG00000082996	37.00	37.55	37.15	36.82	39.80	38.42	-0.0313832595692357	5.45107928457612	0.659215966942042	0.900104683947587	3:149812707-149962139:+	RNF13	22;GO:0000139,cellular_component Golgi membrane;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005654,cellular_component nucleoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031902,cellular_component late endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 13 [Source:HGNC Symbol%3BAcc:HGNC:10057]
ENSG00000169188	13.86	15.56	14.49	15.08	13.42	14.43	0.0384016997071172	4.4994951906233	0.659250944583812	0.900104683947587	X:55000356-55009057:+	APEX2	22;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0008311,molecular_function double-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0016829,molecular_function lyase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	APEX2; AP endonuclease 2 [EC:4.2.99.18]; K10772	apurinic/apyrimidinic endodeoxyribonuclease 2 [Source:HGNC Symbol%3BAcc:HGNC:17889]
ENSG00000149503	14.31	15.37	12.59	13.32	17.49	13.25	-0.0500677388966516	5.31220466793266	0.659260724555569	0.900104683947587	11:62123972-62153163:+	INCENP	26;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000795,cellular_component synaptonemal complex;GO:0000800,cellular_component lateral element;GO:0000801,cellular_component central element;GO:0000910,biological_process cytokinesis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005721,cellular_component pericentric heterochromatin;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0010369,cellular_component chromocenter;GO:0016604,cellular_component nuclear body;GO:0016925,biological_process protein sumoylation;GO:0030496,cellular_component midbody;GO:0043234,cellular_component protein complex;GO:0051301,biological_process cell division	NA	inner centromere protein [Source:HGNC Symbol%3BAcc:HGNC:6058]
ENSG00000063601	7.26	7.55	6.42	6.81	6.96	8.36	-0.0547413906379349	3.9906030011181	0.659292142991171	0.900104683947587	X:150692970-150765103:+	MTMR1	15;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	NA	myotubularin related protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7449]
ENSG00000198887	14.03	13.74	13.88	13.92	13.69	13.54	0.0303396410378121	5.51602072702478	0.659340527551559	0.900104683947587	9:70258961-70354888:+	SMC5	25;GO:0000166,molecular_function nucleotide binding;GO:0000722,biological_process telomere maintenance via recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000781,cellular_component chromosome, telomeric region;GO:0000803,cellular_component sex chromosome;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0030054,cellular_component cell junction;GO:0030915,cellular_component Smc5-Smc6 complex;GO:0034184,biological_process positive regulation of maintenance of mitotic sister chromatid cohesion;GO:0035061,cellular_component interchromatin granule;GO:0035861,cellular_component site of double-strand break;GO:0051301,biological_process cell division;GO:0051984,biological_process positive regulation of chromosome segregation;GO:0090398,biological_process cellular senescence	NA	structural maintenance of chromosomes 5 [Source:HGNC Symbol%3BAcc:HGNC:20465]
ENSG00000163412	10.30	11.66	14.24	11.81	10.95	12.03	0.0687264653345845	3.01929139660809	0.659342273604335	0.900104683947587	3:71675415-71754773:-	EIF4E3	8;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005845,cellular_component mRNA cap binding complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation	NA	eukaryotic translation initiation factor 4E family member 3 [Source:HGNC Symbol%3BAcc:HGNC:31837]
ENSG00000250305	1.98	1.84	2.15	1.97	2.22	2.26	-0.0911199974785658	1.89128364984711	0.659361305980457	0.900104683947587	8:12945641-13031503:+	KIAA1456	16;GO:0000049,molecular_function tRNA binding;GO:0002098,biological_process tRNA wobble uridine modification;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0008175,molecular_function tRNA methyltransferase activity;GO:0008198,molecular_function ferrous iron binding;GO:0016300,molecular_function tRNA (uracil) methyltransferase activity;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0055114,biological_process oxidation-reduction process	NA	KIAA1456 [Source:HGNC Symbol%3BAcc:HGNC:26725]
ENSG00000143376	13.27	13.41	13.12	12.49	14.75	14.01	-0.0411442567811325	4.4981257382064	0.659462907235444	0.900144388334459	1:151612064-151699091:+	SNX27	22;GO:0001770,biological_process establishment of natural killer cell polarity;GO:0001772,cellular_component immunological synapse;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0030904,cellular_component retromer complex;GO:0031901,cellular_component early endosome membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0071203,cellular_component WASH complex;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	sorting nexin family member 27 [Source:HGNC Symbol%3BAcc:HGNC:20073]
ENSG00000103932	7.35	7.65	7.27	7.49	7.87	7.59	-0.0346309385912214	5.04027233567288	0.659559077383564	0.900176671529651	15:41517175-41544269:-	RPAP1	7;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity	NA	RNA polymerase II associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:24567]
ENSG00000108352	2.04	1.90	2.82	2.30	1.72	2.36	0.100594613060879	2.26589098194362	0.659921134595395	0.900571794605611	17:40177009-40195656:+	RAPGEFL1	9;GO:0005057,molecular_function receptor signaling protein activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity	NA	Rap guanine nucleotide exchange factor like 1 [Source:HGNC Symbol%3BAcc:HGNC:17428]
ENSG00000155275	5.68	5.40	5.57	5.92	5.54	5.90	-0.046735573188561	3.72423582676367	0.66009190014066	0.90070581031615	4:8436139-8493531:+	TRMT44	8;GO:0005737,cellular_component cytoplasm;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016300,molecular_function tRNA (uracil) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	tRNA methyltransferase 44 homolog (S. cerevisiae) [Source:HGNC Symbol%3BAcc:HGNC:26653]
ENSG00000148057	10.02	6.78	11.05	11.51	8.61	9.72	-0.0726542846694623	3.06426039726444	0.660376008352441	0.900971572075637	9:83623048-83644130:+	IDNK	10;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0005524,molecular_function ATP binding;GO:0005975,biological_process carbohydrate metabolic process;GO:0008150,biological_process biological_process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046177,biological_process D-gluconate catabolic process;GO:0046316,molecular_function gluconokinase activity	NA	IDNK%2C gluconokinase [Source:HGNC Symbol%3BAcc:HGNC:31367]
ENSG00000139508	3.20	3.44	2.75	2.85	3.33	2.73	0.0800505960257058	2.12884576880325	0.660489253245646	0.900971572075637	13:28700063-28718970:-	SLC46A3	6;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1; K14613	solute carrier family 46 member 3 [Source:HGNC Symbol%3BAcc:HGNC:27501]
ENSG00000101265	14.80	14.07	12.87	15.31	14.97	13.30	-0.0488857673269035	3.81392728622205	0.660504415200862	0.900971572075637	20:4780022-4823645:-	RASSF2	31;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0038168,biological_process epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046849,biological_process bone remodeling;GO:0048872,biological_process homeostasis of number of cells;GO:0050821,biological_process protein stabilization;GO:1901222,biological_process regulation of NIK/NF-kappaB signaling;GO:1901223,biological_process negative regulation of NIK/NF-kappaB signaling	RASSF2_4; Ras association domain-containing protein 2/4; K09851	Ras association domain family member 2 [Source:HGNC Symbol%3BAcc:HGNC:9883]
ENSG00000181513	19.34	14.32	17.49	17.93	15.49	20.33	-0.052675380683229	4.21616905670104	0.660705535092219	0.901082631907425	17:45132599-45144181:+	ACBD4	4;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	acyl-CoA binding domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:23337]
ENSG00000163536	0.91	0.85	1.37	1.33	1.17	1.02	-0.13631977174046	0.615752970810324	0.660764851639052	0.901082631907425	3:167735242-167825568:+	SERPINI1	16;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007417,biological_process central nervous system development;GO:0007422,biological_process peripheral nervous system development;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0010976,biological_process positive regulation of neuron projection development;GO:0030155,biological_process regulation of cell adhesion;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034774,cellular_component secretory granule lumen;GO:0043025,cellular_component neuronal cell body;GO:0043204,cellular_component perikaryon;GO:0060205,cellular_component cytoplasmic membrane-bounded vesicle lumen;GO:0070062,cellular_component extracellular exosome	NA	serpin family I member 1 [Source:HGNC Symbol%3BAcc:HGNC:8943]
ENSG00000169564	250.50	257.53	249.68	255.25	261.19	260.99	-0.025627374752404	8.09573602680973	0.660803608978755	0.901082631907425	2:70087453-70089203:+	PCBP1	22;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0016607,cellular_component nuclear speck;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0039694,biological_process viral RNA genome replication;GO:0045296,molecular_function cadherin binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070062,cellular_component extracellular exosome;GO:0098847,molecular_function sequence-specific single stranded DNA binding	NA	poly(rC) binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8647]
ENSG00000151689	3.13	2.00	3.69	3.69	3.42	2.58	-0.0996130617152712	1.95765007159624	0.661045170391314	0.901243661440582	2:190343469-190371665:+	INPP1	10;GO:0004441,molecular_function inositol-1,4-bisphosphate 1-phosphatase activity;GO:0005829,cellular_component cytosol;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0007165,biological_process signal transduction;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0052829,molecular_function inositol-1,3,4-trisphosphate 1-phosphatase activity	INPP1; inositol polyphosphate 1-phosphatase [EC:3.1.3.57]; K01107	inositol polyphosphate-1-phosphatase [Source:HGNC Symbol%3BAcc:HGNC:6071]
ENSG00000204228	3.52	3.05	2.82	2.49	2.32	3.86	0.121692195516963	1.33319534545946	0.661252024455197	0.901243661440582	6:33204641-33206831:+	HSD17B8	22;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0004303,molecular_function estradiol 17-beta-dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006703,biological_process estrogen biosynthetic process;GO:0008209,biological_process androgen metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0047025,molecular_function 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity;GO:0047035,molecular_function testosterone dehydrogenase (NAD+) activity;GO:0051290,biological_process protein heterotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0070404,molecular_function NADH binding	HSD17B8; 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 3-oxoacyl-[acyl-carrier protein] reductase alpha subunit [EC:1.1.1.62 1.1.1.239]; K13370	hydroxysteroid 17-beta dehydrogenase 8 [Source:HGNC Symbol%3BAcc:HGNC:3554]
ENSG00000011426	45.06	53.16	39.60	43.60	57.61	42.77	-0.0521880973372923	7.34016700669027	0.661271349980756	0.901243661440582	7:36389805-36453791:+	ANLN	20;GO:0000281,biological_process mitotic cytokinesis;GO:0000921,biological_process septin ring assembly;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003779,molecular_function actin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005826,cellular_component actomyosin contractile ring;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0007049,biological_process cell cycle;GO:0007096,biological_process regulation of exit from mitosis;GO:0015629,cellular_component actin cytoskeleton;GO:0032059,cellular_component bleb;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0051301,biological_process cell division;GO:0090521,biological_process glomerular visceral epithelial cell migration;GO:0099738,cellular_component cell cortex region;GO:1904172,biological_process positive regulation of bleb assembly	NA	anillin actin binding protein [Source:HGNC Symbol%3BAcc:HGNC:14082]
ENSG00000240771	6.54	6.75	7.04	6.59	6.44	6.80	0.046563023903886	3.72672175635482	0.661299096710365	0.901243661440582	12:57610179-57619379:+	ARHGEF25	10;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030016,cellular_component myofibril;GO:0030017,cellular_component sarcomere;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	Rho guanine nucleotide exchange factor 25 [Source:HGNC Symbol%3BAcc:HGNC:30275]
ENSG00000174943	14.97	13.22	12.86	12.19	14.49	13.38	0.04995817283572	4.19835038315383	0.661320723244352	0.901243661440582	16:29905011-29927035:-	KCTD13	16;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0016477,biological_process cell migration;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0017049,molecular_function GTP-Rho binding;GO:0019904,molecular_function protein domain specific binding;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0042802,molecular_function identical protein binding;GO:0043149,biological_process stress fiber assembly;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045740,biological_process positive regulation of DNA replication;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 13 [Source:HGNC Symbol%3BAcc:HGNC:22234]
ENSG00000067048	32.23	27.92	29.86	28.97	31.30	32.65	-0.0310790750657108	5.94781423425002	0.661585517751035	0.901243661440582	Y:12904107-12920478:+	DDX3Y	18;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006413,biological_process translational initiation;GO:0007059,biological_process chromosome segregation;GO:0010468,biological_process regulation of gene expression;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule	DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]; K11594	DEAD-box helicase 3%2C Y-linked [Source:HGNC Symbol%3BAcc:HGNC:2699]
ENSG00000259120	10.63	6.17	11.08	10.06	10.19	5.29	0.17498140355175	0.866601934506249	0.66166366796726	0.901243661440582	17:75646242-75647977:+	SMIM6	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 6 [Source:HGNC Symbol%3BAcc:HGNC:40032]
ENSG00000172171	13.39	12.97	12.56	12.45	14.24	11.18	0.0537863716585833	3.84684743341836	0.661752404570696	0.901243661440582	17:30897335-30906820:-	TEFM	13;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006119,biological_process oxidative phosphorylation;GO:0006259,biological_process DNA metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0030337,molecular_function DNA polymerase processivity factor activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042645,cellular_component mitochondrial nucleoid	NA	transcription elongation factor%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:26223]
ENSG00000117597	13.13	14.54	13.74	13.57	12.99	14.12	0.0321160619171603	5.04625564326852	0.661768545979733	0.901243661440582	1:209828006-209857565:+	DIEXF	11;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0007275,biological_process multicellular organism development;GO:0019843,molecular_function rRNA binding;GO:0032040,cellular_component small-subunit processome;GO:0034511,molecular_function U3 snoRNA binding	NA	digestive organ expansion factor homolog (zebrafish) [Source:HGNC Symbol%3BAcc:HGNC:28440]
ENSG00000167283	331.98	374.00	343.70	363.50	371.25	345.51	-0.031420246614255	6.84770324727784	0.661796106365491	0.901243661440582	11:118401153-118431496:+	ATP5L	19;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeFG, ATP5L, ATP20; F-type H+-transporting ATPase subunit g; K02140	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit G [Source:HGNC Symbol%3BAcc:HGNC:14247]
ENSG00000221823	11.77	7.54	8.01	9.06	10.78	9.62	-0.0810526949024777	2.48298605233521	0.661922156434521	0.901243661440582	2:68178856-68256237:-	PPP3R1	21;GO:0004723,molecular_function calcium-dependent protein serine/threonine phosphatase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005955,cellular_component calcineurin complex;GO:0006470,biological_process protein dephosphorylation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0016018,molecular_function cyclosporin A binding;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0033173,biological_process calcineurin-NFAT signaling cascade;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042383,cellular_component sarcolemma;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit; K06268	protein phosphatase 3 regulatory subunit B%2C alpha [Source:HGNC Symbol%3BAcc:HGNC:9317]
ENSG00000099810	17.41	17.65	17.14	20.33	16.42	17.52	-0.0451429239252259	4.37962243250203	0.66196360147543	0.901243661440582	9:21802542-21937651:+	MTAP	17;GO:0003824,molecular_function catalytic activity;GO:0004645,molecular_function phosphorylase activity;GO:0004731,molecular_function purine-nucleoside phosphorylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006166,biological_process purine ribonucleoside salvage;GO:0009116,biological_process nucleoside metabolic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016763,molecular_function transferase activity, transferring pentosyl groups;GO:0017061,molecular_function S-methyl-5-thioadenosine phosphorylase activity;GO:0019509,biological_process L-methionine biosynthetic process from methylthioadenosine;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome	mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]; K00772	methylthioadenosine phosphorylase [Source:HGNC Symbol%3BAcc:HGNC:7413]
ENSG00000134490	5.11	3.61	5.56	5.11	5.25	5.02	-0.0719342148963124	2.29508709256745	0.662004162882715	0.901243661440582	18:23197143-23437961:-	TMEM241	8;GO:0005338,molecular_function nucleotide-sugar transmembrane transporter activity;GO:0005457,molecular_function GDP-fucose transmembrane transporter activity;GO:0005794,cellular_component Golgi apparatus;GO:0008643,biological_process carbohydrate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036085,biological_process GDP-fucose import into Golgi lumen;GO:1990570,biological_process GDP-mannose transmembrane transport	NA	transmembrane protein 241 [Source:HGNC Symbol%3BAcc:HGNC:31723]
ENSG00000132256	25.99	28.65	28.30	28.40	28.51	28.43	-0.0322029228247201	5.63067660242958	0.662020535722262	0.901243661440582	11:5663556-5938619:-	TRIM5	34;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0002218,biological_process activation of innate immune response;GO:0002221,biological_process pattern recognition receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0008270,molecular_function zinc ion binding;GO:0008329,molecular_function signaling pattern recognition receptor activity;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0030674,molecular_function protein binding, bridging;GO:0031664,biological_process regulation of lipopolysaccharide-mediated signaling pathway;GO:0032880,biological_process regulation of protein localization;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045087,biological_process innate immune response;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0070534,biological_process protein K63-linked ubiquitination;GO:1902187,biological_process negative regulation of viral release from host cell;GO:1990462,cellular_component omegasome	TRIM5; tripartite motif-containing protein 5 [EC:2.3.2.27]; K10648	tripartite motif containing 5 [Source:HGNC Symbol%3BAcc:HGNC:16276]
ENSG00000101003	18.74	23.24	18.28	21.90	19.48	16.50	0.0612544491098167	3.54370260070663	0.662076336899031	0.901243661440582	20:25407726-25452628:+	GINS1	10;GO:0000811,cellular_component GINS complex;GO:0001833,biological_process inner cell mass cell proliferation;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006271,biological_process DNA strand elongation involved in DNA replication;GO:0032508,biological_process DNA duplex unwinding;GO:0043138,molecular_function 3'-5' DNA helicase activity;GO:1902983,biological_process DNA strand elongation involved in mitotic DNA replication	NA	GINS complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:28980]
ENSG00000171109	21.06	23.00	20.06	19.60	22.01	21.45	0.0321295269083327	5.56192647022694	0.662083376192433	0.901243661440582	3:179347691-179394931:+	MFN1	17;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0008053,biological_process mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0046039,biological_process GTP metabolic process;GO:0051646,biological_process mitochondrion localization;GO:0098799,cellular_component outer mitochondrial membrane protein complex;GO:1990613,biological_process mitochondrial membrane fusion	MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]; K06030	mitofusin 1 [Source:HGNC Symbol%3BAcc:HGNC:18262]
ENSG00000009724	3.89	3.33	3.31	3.76	3.48	3.87	-0.0622731688078769	2.93432877472328	0.662317450477937	0.90127531541972	1:11026522-11047233:-	MASP2	18;GO:0001855,molecular_function complement component C4b binding;GO:0001867,biological_process complement activation, lectin pathway;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0006956,biological_process complement activation;GO:0006958,biological_process complement activation, classical pathway;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0070062,cellular_component extracellular exosome	MASP2; mannan-binding lectin serine protease 2 [EC:3.4.21.104]; K03993	mannan binding lectin serine peptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:6902]
ENSG00000008710	8.86	7.69	8.99	8.67	7.67	8.83	0.0351083037613205	6.77351398850383	0.662385842432266	0.90127531541972	16:2088709-2135898:-	PKD1	71;GO:0000139,cellular_component Golgi membrane;GO:0001502,biological_process cartilage condensation;GO:0001568,biological_process blood vessel development;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0001889,biological_process liver development;GO:0001892,biological_process embryonic placenta development;GO:0002133,cellular_component polycystin complex;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005929,cellular_component cilium;GO:0006611,biological_process protein export from nucleus;GO:0006807,biological_process nitrogen compound metabolic process;GO:0006816,biological_process calcium ion transport;GO:0007050,biological_process cell cycle arrest;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007160,biological_process cell-matrix adhesion;GO:0007161,biological_process calcium-independent cell-matrix adhesion;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007259,biological_process JAK-STAT cascade;GO:0007507,biological_process heart development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0021510,biological_process spinal cord development;GO:0021915,biological_process neural tube development;GO:0030010,biological_process establishment of cell polarity;GO:0030155,biological_process regulation of cell adhesion;GO:0030246,molecular_function carbohydrate binding;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0031514,cellular_component motile cilium;GO:0031659,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0032092,biological_process positive regulation of protein binding;GO:0034405,biological_process response to fluid shear stress;GO:0036303,biological_process lymph vessel morphogenesis;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0042995,cellular_component cell projection;GO:0043588,biological_process skin development;GO:0044325,molecular_function ion channel binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048565,biological_process digestive tract development;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048806,biological_process genitalia development;GO:0050982,biological_process detection of mechanical stimulus;GO:0051216,biological_process cartilage development;GO:0060170,cellular_component ciliary membrane;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0060428,biological_process lung epithelium development;GO:0060674,biological_process placenta blood vessel development;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport;GO:0072001,biological_process renal system development;GO:0072164,biological_process mesonephric tubule development;GO:0072177,biological_process mesonephric duct development;GO:0072205,biological_process metanephric collecting duct development;GO:0072218,biological_process metanephric ascending thin limb development;GO:0072237,biological_process metanephric proximal tubule development;GO:0072287,biological_process metanephric distal tubule morphogenesis	NA	polycystin 1%2C transient receptor potential channel interacting [Source:HGNC Symbol%3BAcc:HGNC:9008]
ENSG00000181090	13.79	14.16	13.76	14.21	15.00	13.70	-0.0295883677492192	5.99857396687968	0.662468173149523	0.90127531541972	9:137618962-137870016:+	EHMT1	32;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002039,molecular_function p53 binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006306,biological_process DNA methylation;GO:0006325,biological_process chromatin organization;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0009790,biological_process embryo development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0018027,biological_process peptidyl-lysine dimethylation;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046974,molecular_function histone methyltransferase activity (H3-K9 specific);GO:0046976,molecular_function histone methyltransferase activity (H3-K27 specific);GO:0051567,biological_process histone H3-K9 methylation;GO:0060992,biological_process response to fungicide;GO:0070734,biological_process histone H3-K27 methylation;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]; K11420	euchromatic histone lysine methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:24650]
ENSG00000243156	25.46	24.61	24.86	25.25	26.45	25.24	-0.0261569706411898	7.54422293419097	0.662507492154466	0.90127531541972	22:17787648-18024559:-	MICAL3	23;GO:0003779,molecular_function actin binding;GO:0004497,molecular_function monooxygenase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006887,biological_process exocytosis;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0016491,molecular_function oxidoreductase activity;GO:0016709,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0017137,molecular_function Rab GTPase binding;GO:0030042,biological_process actin filament depolymerization;GO:0030496,cellular_component midbody;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	NA	microtubule associated monooxygenase%2C calponin and LIM domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:24694]
ENSG00000174928	5.33	4.29	4.56	4.71	6.00	4.49	-0.0746536188897723	2.49090366854326	0.662523740736095	0.90127531541972	3:155762616-155806351:-	C3orf33	6;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	NA	chromosome 3 open reading frame 33 [Source:HGNC Symbol%3BAcc:HGNC:26434]
ENSG00000128606	0.95	1.50	0.99	0.90	1.88	1.11	-0.181186021939098	0.81727541726169	0.662542274486824	0.90127531541972	7:102912990-102944949:+	LRRC17	5;GO:0001503,biological_process ossification;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0048539,biological_process bone marrow development	NA	leucine rich repeat containing 17 [Source:HGNC Symbol%3BAcc:HGNC:16895]
ENSG00000169136	12.43	11.59	15.32	14.06	13.83	13.43	-0.0511635065221065	3.66987611856849	0.662738750914017	0.901372658953024	19:49928701-49933935:+	ATF5	39;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007623,biological_process circadian rhythm;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009791,biological_process post-embryonic development;GO:0010468,biological_process regulation of gene expression;GO:0015631,molecular_function tubulin binding;GO:0019900,molecular_function kinase binding;GO:0021889,biological_process olfactory bulb interneuron differentiation;GO:0021891,biological_process olfactory bulb interneuron development;GO:0021930,biological_process cerebellar granule cell precursor proliferation;GO:0021988,biological_process olfactory lobe development;GO:0035264,biological_process multicellular organism growth;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045444,biological_process fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046605,biological_process regulation of centrosome cycle;GO:1902750,biological_process negative regulation of cell cycle G2/M phase transition	NA	activating transcription factor 5 [Source:HGNC Symbol%3BAcc:HGNC:790]
ENSG00000134294	177.34	180.17	183.38	184.43	184.49	185.96	-0.025118871688103	8.18802045317434	0.662759063744804	0.901372658953024	12:46358188-46372867:-	SLC38A2	24;GO:0003333,biological_process amino acid transmembrane transport;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006865,biological_process amino acid transport;GO:0007565,biological_process female pregnancy;GO:0014047,biological_process glutamate secretion;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021987,biological_process cerebral cortex development;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031460,biological_process glycine betaine transport;GO:0032328,biological_process alanine transport;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042383,cellular_component sarcolemma;GO:0043025,cellular_component neuronal cell body;GO:0071260,biological_process cellular response to mechanical stimulus	SLC38A2, SNAT2; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 2; K14207	solute carrier family 38 member 2 [Source:HGNC Symbol%3BAcc:HGNC:13448]
ENSG00000261052	1.47	1.04	1.69	1.80	1.16	1.77	-0.136504552771587	0.615183805086379	0.662876049587584	0.901432997757524	16:30199227-30204310:+	SULT1A3	24;GO:0004062,molecular_function aryl sulfotransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006068,biological_process ethanol catabolic process;GO:0006584,biological_process catecholamine metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0008146,molecular_function sulfotransferase activity;GO:0008202,biological_process steroid metabolic process;GO:0009812,biological_process flavonoid metabolic process;GO:0016740,molecular_function transferase activity;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042420,biological_process dopamine catabolic process;GO:0043199,molecular_function sulfate binding;GO:0047685,molecular_function amine sulfotransferase activity;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0051923,biological_process sulfation;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0097720,biological_process calcineurin-mediated signaling;GO:0098989,biological_process NMDA selective glutamate receptor signaling pathway;GO:1901215,biological_process negative regulation of neuron death;GO:1903351,biological_process cellular response to dopamine	SULT1A; aryl sulfotransferase [EC:2.8.2.1]; K01014	sulfotransferase family 1A member 3 [Source:HGNC Symbol%3BAcc:HGNC:11455]
ENSG00000105058	75.60	80.38	80.56	76.23	82.56	74.14	0.0330647579244277	5.2865891700779	0.663095480303679	0.901623357774957	19:16185379-16192046:+	FAM32A	7;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0008150,biological_process biological_process	NA	family with sequence similarity 32 member A [Source:HGNC Symbol%3BAcc:HGNC:24563]
ENSG00000115266	3.90	3.90	3.99	3.89	4.26	3.42	0.0423071929673824	4.75810766720702	0.663161303189024	0.901623357774957	19:1446301-1473244:+	APC2	20;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005884,cellular_component actin filament;GO:0008013,molecular_function beta-catenin binding;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016055,biological_process Wnt signaling pathway;GO:0016342,cellular_component catenin complex;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0031258,cellular_component lamellipodium membrane;GO:0031941,cellular_component filamentous actin;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090630,biological_process activation of GTPase activity	APC; adenomatosis polyposis coli protein; K02085	APC2%2C WNT signaling pathway regulator [Source:HGNC Symbol%3BAcc:HGNC:24036]
ENSG00000109133	26.63	25.51	25.17	27.44	30.28	22.81	-0.044549324045672	4.49981588045448	0.663313321814966	0.901729085478048	4:41935119-41960572:+	TMEM33	19;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0034613,biological_process cellular protein localization;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0042470,cellular_component melanosome;GO:0051292,biological_process nuclear pore complex assembly;GO:0070062,cellular_component extracellular exosome;GO:1903371,biological_process regulation of endoplasmic reticulum tubular network organization;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response;GO:1903899,biological_process positive regulation of PERK-mediated unfolded protein response	NA	transmembrane protein 33 [Source:HGNC Symbol%3BAcc:HGNC:25541]
ENSG00000213316	4.07	1.27	1.63	2.82	2.35	2.96	-0.163645045796764	0.396190958982231	0.663404856784192	0.901729085478048	5:179793979-179796647:+	LTC4S	21;GO:0004364,molecular_function glutathione transferase activity;GO:0004464,molecular_function leukotriene-C4 synthase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005640,cellular_component nuclear outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006691,biological_process leukotriene metabolic process;GO:0008047,molecular_function enzyme activator activity;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0019370,biological_process leukotriene biosynthetic process;GO:0019372,biological_process lipoxygenase pathway;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0098869,biological_process cellular oxidant detoxification;GO:2001300,biological_process lipoxin metabolic process	LTC4S; leukotriene-C4 synthase [EC:4.4.1.20]; K00807	leukotriene C4 synthase [Source:HGNC Symbol%3BAcc:HGNC:6719]
ENSG00000100614	32.20	30.92	31.05	30.10	32.98	33.98	-0.0313584427311871	5.55141403172641	0.663483150427152	0.901729085478048	14:60245751-60299087:+	PPM1A	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006499,biological_process N-terminal protein myristoylation;GO:0007050,biological_process cell cycle arrest;GO:0010991,biological_process negative regulation of SMAD protein complex assembly;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0033192,molecular_function calmodulin-dependent protein phosphatase activity;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043169,molecular_function cation binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0046872,molecular_function metal ion binding;GO:0070412,molecular_function R-SMAD binding;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus	PPM1A, PP2CA; protein phosphatase 1A [EC:3.1.3.16]; K04457	protein phosphatase%2C Mg2+/Mn2+ dependent 1A [Source:HGNC Symbol%3BAcc:HGNC:9275]
ENSG00000106144	15.60	17.34	15.73	16.49	15.45	15.69	0.0374601601786466	4.49165747351103	0.663559871610574	0.901729085478048	7:143288214-143307696:+	CASP2	35;GO:0001554,biological_process luteolysis;GO:0003407,biological_process neural retina development;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007420,biological_process brain development;GO:0007568,biological_process aging;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016020,cellular_component membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0035234,biological_process ectopic germ cell programmed cell death;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0097153,molecular_function cysteine-type endopeptidase activity involved in apoptotic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097194,biological_process execution phase of apoptosis;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	CASP2; caspase 2 [EC:3.4.22.55]; K02186	caspase 2 [Source:HGNC Symbol%3BAcc:HGNC:1503]
ENSG00000149782	15.93	16.19	16.10	16.44	14.85	16.32	0.0290891236946312	5.89023833020263	0.663605904654653	0.901729085478048	11:64251522-64269150:+	PLCB3	20;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0004435,molecular_function phosphatidylinositol phospholipase C activity;GO:0004629,molecular_function phospholipase C activity;GO:0004871,molecular_function signal transducer activity;GO:0005509,molecular_function calcium ion binding;GO:0005516,molecular_function calmodulin binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0035556,biological_process intracellular signal transduction;GO:0043234,cellular_component protein complex;GO:0043647,biological_process inositol phosphate metabolic process;GO:0045296,molecular_function cadherin binding	PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]; K05858	phospholipase C beta 3 [Source:HGNC Symbol%3BAcc:HGNC:9056]
ENSG00000146416	249.24	246.74	248.33	254.32	258.76	250.81	-0.0255636254769407	7.64293633664618	0.663775999711057	0.901729085478048	6:143060495-143340304:+	AIG1	4;GO:0005515,molecular_function protein binding;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	androgen induced 1 [Source:HGNC Symbol%3BAcc:HGNC:21607]
ENSG00000164344	0.30	0.59	0.31	0.39	0.54	0.43	-0.216073717663632	0.0555799317870807	0.663800761273105	0.901729085478048	4:186208978-186258471:+	KLKB1	27;GO:0002542,biological_process Factor XII activation;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0004497,molecular_function monooxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006954,biological_process inflammatory response;GO:0007596,biological_process blood coagulation;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0007599,biological_process hemostasis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016787,molecular_function hydrolase activity;GO:0020037,molecular_function heme binding;GO:0022617,biological_process extracellular matrix disassembly;GO:0031638,biological_process zymogen activation;GO:0031639,biological_process plasminogen activation;GO:0042730,biological_process fibrinolysis;GO:0046872,molecular_function metal ion binding;GO:0051919,biological_process positive regulation of fibrinolysis;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	KLKB1; plasma kallikrein [EC:3.4.21.34]; K01324	kallikrein B1 [Source:HGNC Symbol%3BAcc:HGNC:6371]
ENSG00000099949	11.50	13.41	11.86	11.71	12.68	11.68	0.033984851944861	5.091121498536	0.663906846078207	0.901729085478048	22:20979461-20999038:+	LZTR1	4;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005794,cellular_component Golgi apparatus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009653,biological_process anatomical structure morphogenesis	NA	leucine zipper like transcription regulator 1 [Source:HGNC Symbol%3BAcc:HGNC:6742]
ENSG00000128710	49.85	36.73	51.38	48.89	43.57	51.50	-0.0447340067761176	5.59324074638533	0.663936075820793	0.901729085478048	2:176108789-176119942:+	HOXD10	29;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007338,biological_process single fertilization;GO:0007519,biological_process skeletal muscle tissue development;GO:0008344,biological_process adult locomotory behavior;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009954,biological_process proximal/distal pattern formation;GO:0010468,biological_process regulation of gene expression;GO:0021520,biological_process spinal cord motor neuron cell fate specification;GO:0030326,biological_process embryonic limb morphogenesis;GO:0035136,biological_process forelimb morphogenesis;GO:0035137,biological_process hindlimb morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048935,biological_process peripheral nervous system neuron development;GO:0050905,biological_process neuromuscular process	NA	homeobox D10 [Source:HGNC Symbol%3BAcc:HGNC:5133]
ENSG00000171497	23.26	26.24	20.97	22.77	23.33	22.79	0.0374433829300494	4.7455027737268	0.663965507231883	0.901729085478048	4:158709133-158723396:-	PPID	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006461,biological_process protein complex assembly;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0008134,molecular_function transcription factor binding;GO:0015031,biological_process protein transport;GO:0016018,molecular_function cyclosporin A binding;GO:0016853,molecular_function isomerase activity;GO:0019076,biological_process viral release from host cell;GO:0030331,molecular_function estrogen receptor binding;GO:0030544,molecular_function Hsp70 protein binding;GO:0031072,molecular_function heat shock protein binding;GO:0034389,biological_process lipid particle organization;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045070,biological_process positive regulation of viral genome replication;GO:0050714,biological_process positive regulation of protein secretion;GO:0051879,molecular_function Hsp90 protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0071492,biological_process cellular response to UV-A	PPID, CYPD; peptidyl-prolyl isomerase D [EC:5.2.1.8]; K05864	peptidylprolyl isomerase D [Source:HGNC Symbol%3BAcc:HGNC:9257]
ENSG00000041880	28.38	25.46	29.17	29.03	27.49	25.27	0.0377656679292815	5.4872497928363	0.664150480123747	0.901771562696869	3:51942344-51948867:+	PARP3	22;GO:0000723,biological_process telomere maintenance;GO:0003824,molecular_function catalytic activity;GO:0003910,molecular_function DNA ligase (ATP) activity;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006273,biological_process lagging strand elongation;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006471,biological_process protein ADP-ribosylation;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0035861,cellular_component site of double-strand break;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0051106,biological_process positive regulation of DNA ligation;GO:0060236,biological_process regulation of mitotic spindle organization;GO:1990166,biological_process protein localization to site of double-strand break	PARP; poly [ADP-ribose] polymerase [EC:2.4.2.30]; K10798	poly(ADP-ribose) polymerase family member 3 [Source:HGNC Symbol%3BAcc:HGNC:273]
ENSG00000239382	17.02	19.13	18.82	14.74	21.79	16.55	0.0608716302881134	4.0034517295223	0.664280930514949	0.901771562696869	19:36009119-36014239:-	ALKBH6	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005925,cellular_component focal adhesion;GO:0008198,molecular_function ferrous iron binding;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	alkB homolog 6 [Source:HGNC Symbol%3BAcc:HGNC:28243]
ENSG00000066557	22.64	21.17	21.44	22.35	23.27	21.69	-0.0302395383989814	5.32525030101868	0.664383965083004	0.901771562696869	1:70144804-70205620:-	LRRC40	3;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane	NA	leucine rich repeat containing 40 [Source:HGNC Symbol%3BAcc:HGNC:26004]
ENSG00000149100	142.53	131.68	139.58	142.96	128.32	137.72	0.0293516394205102	7.31506045952402	0.664443354880655	0.901771562696869	11:32583797-32606262:+	EIF3M	10;GO:0002183,biological_process cytoplasmic translational initiation;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0031369,molecular_function translation initiation factor binding;GO:0071541,cellular_component eukaryotic translation initiation factor 3 complex, eIF3m	NA	eukaryotic translation initiation factor 3 subunit M [Source:HGNC Symbol%3BAcc:HGNC:24460]
ENSG00000186141	31.48	32.03	31.29	33.93	30.58	33.05	-0.0310090154069836	5.6877343060693	0.664510116192162	0.901771562696869	1:145824087-145842505:+	POLR3C	17;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0051607,biological_process defense response to virus	RPC3, POLR3C; DNA-directed RNA polymerase III subunit RPC3; K03023	RNA polymerase III subunit C [Source:HGNC Symbol%3BAcc:HGNC:30076]
ENSG00000000457	6.22	6.14	6.98	6.05	5.89	6.89	0.05067059462193	3.84209010726691	0.664518770480332	0.901771562696869	1:169849630-169894267:-	SCYL3	9;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0016477,biological_process cell migration;GO:0030027,cellular_component lamellipodium;GO:0042995,cellular_component cell projection	NA	SCY1 like pseudokinase 3 [Source:HGNC Symbol%3BAcc:HGNC:19285]
ENSG00000101247	7.99	8.51	9.42	9.58	7.81	9.91	-0.0651587541352875	3.2833043920667	0.664575914181167	0.901771562696869	20:13784949-13821582:+	NDUFAF5	14;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016740,molecular_function transferase activity;GO:0030961,biological_process peptidyl-arginine hydroxylation;GO:0031314,cellular_component extrinsic component of mitochondrial inner membrane;GO:0032259,biological_process methylation;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process	NA	NADH:ubiquinone oxidoreductase complex assembly factor 5 [Source:HGNC Symbol%3BAcc:HGNC:15899]
ENSG00000050426	28.46	24.42	26.13	26.01	25.77	26.09	0.0382671942785775	4.96465265829338	0.664577963067023	0.901771562696869	12:51047961-51060424:+	LETMD1	9;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006875,biological_process cellular metal ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043022,molecular_function ribosome binding	NA	LETM1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24241]
ENSG00000151458	7.94	8.60	7.90	7.88	8.30	7.87	0.0314168078564955	5.11985089345838	0.664689331789325	0.901784526646903	4:124664051-124712732:-	ANKRD50	5;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	ankyrin repeat domain 50 [Source:HGNC Symbol%3BAcc:HGNC:29223]
ENSG00000112339	21.87	24.96	22.77	22.94	23.40	25.32	-0.0331385800265171	6.42860275313196	0.664759166823184	0.901784526646903	6:134960377-135103056:-	HBS1L	14;GO:0000166,molecular_function nucleotide binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0070062,cellular_component extracellular exosome	HBS1; elongation factor 1 alpha-like protein; K14416	HBS1 like translational GTPase [Source:HGNC Symbol%3BAcc:HGNC:4834]
ENSG00000116212	47.85	47.86	40.76	46.12	43.53	44.69	0.0323691029298569	5.86049892791296	0.66490423952824	0.901784526646903	1:53946076-53968168:+	LRRC42	NA	NA	leucine rich repeat containing 42 [Source:HGNC Symbol%3BAcc:HGNC:28792]
ENSG00000127314	136.73	140.83	140.37	137.05	139.43	136.92	0.0269521654731305	6.4393941389903	0.665186403863668	0.901784526646903	12:68610838-68671901:+	RAP1B	33;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008283,biological_process cell proliferation;GO:0009743,biological_process response to carbohydrate;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030054,cellular_component cell junction;GO:0032403,molecular_function protein complex binding;GO:0032486,biological_process Rap protein signal transduction;GO:0035577,cellular_component azurophil granule membrane;GO:0035690,biological_process cellular response to drug;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043312,biological_process neutrophil degranulation;GO:0045955,biological_process negative regulation of calcium ion-dependent exocytosis;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071320,biological_process cellular response to cAMP;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0097211,biological_process cellular response to gonadotropin-releasing hormone;GO:1901888,biological_process regulation of cell junction assembly;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000301,biological_process negative regulation of synaptic vesicle exocytosis	NA	RAP1B%2C member of RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9857]
ENSG00000138802	16.76	16.01	17.13	15.20	16.97	17.12	0.0310570564358053	6.01458654231482	0.665220726678595	0.901784526646903	4:109433771-109540896:+	SEC24B	35;GO:0000139,cellular_component Golgi membrane;GO:0001843,biological_process neural tube closure;GO:0002093,biological_process auditory receptor cell morphogenesis;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0003151,biological_process outflow tract morphogenesis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008270,molecular_function zinc ion binding;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0021747,biological_process cochlear nucleus development;GO:0030127,cellular_component COPII vesicle coat;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0035909,biological_process aorta morphogenesis;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060088,biological_process auditory receptor cell stereocilium organization;GO:0060425,biological_process lung morphogenesis;GO:0060463,biological_process lung lobe morphogenesis;GO:0060982,biological_process coronary artery morphogenesis;GO:0061156,biological_process pulmonary artery morphogenesis;GO:0072358,biological_process cardiovascular system development;GO:0090110,biological_process cargo loading into COPII-coated vesicle;GO:0090178,biological_process regulation of establishment of planar polarity involved in neural tube closure;GO:1901301,biological_process regulation of cargo loading into COPII-coated vesicle	SEC24; protein transport protein SEC24; K14007	SEC24 homolog B%2C COPII coat complex component [Source:HGNC Symbol%3BAcc:HGNC:10704]
ENSG00000253710	4.97	5.84	5.95	4.53	5.83	5.78	0.0602766292726352	3.08403986313901	0.665242571719059	0.901784526646903	13:52012397-52029664:+	ALG11	10;GO:0004377,molecular_function GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006490,biological_process oligosaccharide-lipid intermediate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0033577,biological_process protein glycosylation in endoplasmic reticulum;GO:0097502,biological_process mannosylation	UTP14; U3 small nucleolar RNA-associated protein 14; K14567	ALG11%2C alpha-1%2C2-mannosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:32456]
ENSG00000152894	43.78	40.35	40.96	39.90	42.47	41.40	0.0275476312247169	7.6490698598833	0.665579513015545	0.901784526646903	6:127968778-128520674:-	PTPRK	40;GO:0001750,cellular_component photoreceptor outer segment;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0006470,biological_process protein dephosphorylation;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0008013,molecular_function beta-catenin binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030336,biological_process negative regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031175,biological_process neuron projection development;GO:0031256,cellular_component leading edge membrane;GO:0034394,biological_process protein localization to cell surface;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0034644,biological_process cellular response to UV;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045295,molecular_function gamma-catenin binding;GO:0045786,biological_process negative regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048041,biological_process focal adhesion assembly	NA	protein tyrosine phosphatase%2C receptor type K [Source:HGNC Symbol%3BAcc:HGNC:9674]
ENSG00000156313	3.56	2.65	3.51	3.60	2.83	3.01	0.0648029309365804	3.93586265958433	0.665607330416606	0.901784526646903	X:38269162-38327564:-	RPGR	20;GO:0001750,cellular_component photoreceptor outer segment;GO:0003723,molecular_function RNA binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006886,biological_process intracellular protein transport;GO:0007601,biological_process visual perception;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0036126,cellular_component sperm flagellum;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050896,biological_process response to stimulus;GO:0060271,biological_process cilium morphogenesis	NA	retinitis pigmentosa GTPase regulator [Source:HGNC Symbol%3BAcc:HGNC:10295]
ENSG00000184677	7.30	7.28	7.43	7.82	7.49	7.42	-0.0340686918224871	4.80102274062493	0.665614760012745	0.901784526646903	1:22451850-22531157:+	ZBTB40	9;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0030282,biological_process bone mineralization;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 40 [Source:HGNC Symbol%3BAcc:HGNC:29045]
ENSG00000165030	96.31	75.43	94.68	88.00	81.10	92.64	0.0394433249797572	6.93526656860932	0.665638467473077	0.901784526646903	9:91409044-91423862:-	NFIL3	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0007623,biological_process circadian rhythm;GO:0010628,biological_process positive regulation of gene expression;GO:0048511,biological_process rhythmic process;GO:0071353,biological_process cellular response to interleukin-4	NA	nuclear factor%2C interleukin 3 regulated [Source:HGNC Symbol%3BAcc:HGNC:7787]
ENSG00000161265	5.89	6.24	8.90	8.24	6.51	5.10	0.101838809219195	2.53372267208716	0.665697909244413	0.901784526646903	19:35742463-35745445:-	U2AF1L4	17;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0030628,molecular_function pre-mRNA 3'-splice site binding;GO:0031124,biological_process mRNA 3'-end processing;GO:0046872,molecular_function metal ion binding;GO:0089701,cellular_component U2AF	U2AF1; splicing factor U2AF 35 kDa subunit; K12836	U2 small nuclear RNA auxiliary factor 1 like 4 [Source:HGNC Symbol%3BAcc:HGNC:23020]
ENSG00000134871	80.42	76.08	77.09	79.15	81.76	78.76	-0.0251203718488752	8.68546914009277	0.665766261077671	0.901784526646903	13:110305811-110513027:+	COL4A2	19;GO:0001525,biological_process angiogenesis;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005587,cellular_component collagen type IV trimer;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006351,biological_process transcription, DNA-templated;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0035987,biological_process endodermal cell differentiation;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus	COL4A; collagen, type IV, alpha; K06237	collagen type IV alpha 2 chain [Source:HGNC Symbol%3BAcc:HGNC:2203]
ENSG00000103064	7.33	6.28	6.88	6.28	6.77	6.91	0.0568148253415855	3.50637020578772	0.665774462610337	0.901784526646903	16:68264515-68301823:+	SLC7A6	17;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015179,molecular_function L-amino acid transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015807,biological_process L-amino acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050900,biological_process leukocyte migration;GO:1902475,biological_process L-alpha-amino acid transmembrane transport	NA	solute carrier family 7 member 6 [Source:HGNC Symbol%3BAcc:HGNC:11064]
ENSG00000231274	1.17	0.86	0.83	1.07	0.74	1.43	-0.16211465539088	0.603248117254004	0.665788235357245	0.901784526646903	19:55540655-55545543:-	SBK3	8;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	SH3 domain binding kinase family member 3 [Source:HGNC Symbol%3BAcc:HGNC:44121]
ENSG00000204392	94.66	93.55	107.17	96.15	99.26	110.78	-0.0385409624265305	4.84726516764842	0.665795627243193	0.901784526646903	6:31797395-31806984:-	LSM2	19;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005688,cellular_component U6 snRNP;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0017070,molecular_function U6 snRNA binding;GO:0017160,molecular_function Ral GTPase binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1990726,cellular_component Lsm1-7-Pat1 complex	LSM2; U6 snRNA-associated Sm-like protein LSm2; K12621	LSM2 homolog%2C U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol%3BAcc:HGNC:13940]
ENSG00000188234	5.14	5.47	3.68	4.43	4.93	4.34	0.0653233946648589	3.28098255298008	0.665858043281787	0.901784526646903	10:45825593-45853875:-	AGAP4	3;GO:0005096,molecular_function GTPase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	NA	ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 4 [Source:HGNC Symbol%3BAcc:HGNC:23459]
ENSG00000175602	66.66	61.34	62.06	63.38	56.69	77.51	-0.0440599748917062	5.29969667199039	0.665909418853345	0.901784526646903	11:65890111-65891635:+	CCDC85B	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0040008,biological_process regulation of growth;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	coiled-coil domain containing 85B [Source:HGNC Symbol%3BAcc:HGNC:24926]
ENSG00000137463	1.86	2.39	2.04	2.39	1.47	1.76	0.158153781457179	0.652062828238265	0.666008847739683	0.901784526646903	4:139266162-139280338:-	MGARP	16;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0008089,biological_process anterograde axonal transport;GO:0008090,biological_process retrograde axonal transport;GO:0010821,biological_process regulation of mitochondrion organization;GO:0010822,biological_process positive regulation of mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019896,biological_process axonal transport of mitochondrion;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0097211,biological_process cellular response to gonadotropin-releasing hormone;GO:1904115,cellular_component axon cytoplasm	NA	mitochondria localized glutamic acid rich protein [Source:HGNC Symbol%3BAcc:HGNC:29969]
ENSG00000015520	0.69	0.80	0.78	0.64	0.93	0.53	0.116295189891799	1.63505297465225	0.666094768947841	0.901784526646903	7:44512534-44541315:-	NPC1L1	22;GO:0005319,molecular_function lipid transporter activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006869,biological_process lipid transport;GO:0008144,molecular_function drug binding;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030299,biological_process intestinal cholesterol absorption;GO:0030301,biological_process cholesterol transport;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0031526,cellular_component brush border membrane;GO:0042157,biological_process lipoprotein metabolic process;GO:0042493,biological_process response to drug;GO:0098856,biological_process intestinal lipid absorption	NPC1L1; Niemann-Pick C1-like protein 1; K14461	NPC1 like intracellular cholesterol transporter 1 [Source:HGNC Symbol%3BAcc:HGNC:7898]
ENSG00000167716	5.65	6.76	5.34	5.00	6.51	5.78	0.0444354824262361	5.10577269545276	0.666099742964186	0.901784526646903	17:1716522-1738599:+	WDR81	2;GO:0005739,cellular_component mitochondrion;GO:0010923,biological_process negative regulation of phosphatase activity	NA	WD repeat domain 81 [Source:HGNC Symbol%3BAcc:HGNC:26600]
ENSG00000137522	27.03	24.79	26.68	28.24	25.40	23.48	0.0417275067340747	4.82677261270417	0.666113133394462	0.901784526646903	11:71928700-71997597:+	RNF121	9;GO:0000139,cellular_component Golgi membrane;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 121 [Source:HGNC Symbol%3BAcc:HGNC:21070]
ENSG00000173064	4.85	4.55	4.55	4.80	4.59	4.96	-0.0284988670973777	5.99767277371609	0.666339327287563	0.901992374004419	12:112160187-112382439:-	HECTD4	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity	NA	HECT domain E3 ubiquitin protein ligase 4 [Source:HGNC Symbol%3BAcc:HGNC:26611]
ENSG00000151093	12.41	12.49	10.74	13.59	12.34	11.23	-0.0502710908403969	4.07468734799448	0.666444879828562	0.902036887287313	3:25782916-25794534:+	OXSM	14;GO:0003824,molecular_function catalytic activity;GO:0004315,molecular_function 3-oxoacyl-[acyl-carrier-protein] synthase activity;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0051790,biological_process short-chain fatty acid biosynthetic process;GO:0051792,biological_process medium-chain fatty acid biosynthetic process	fabF, OXSM, CEM1; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]; K09458	3-oxoacyl-ACP synthase%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:26063]
ENSG00000168653	490.16	534.02	477.02	499.15	563.09	485.15	-0.032881267628297	7.33773653010906	0.66663928283722	0.902201637359182	1:39026317-39034636:+	NDUFS5	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5; K03938	NADH:ubiquinone oxidoreductase subunit S5 [Source:HGNC Symbol%3BAcc:HGNC:7712]
ENSG00000166783	13.88	13.79	14.01	13.93	13.86	13.46	0.0274551275741393	6.18563163471175	0.667179352510902	0.902562222935504	16:15594385-15643166:-	MARF1	14;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005777,cellular_component peroxisome;GO:0005794,cellular_component Golgi apparatus;GO:0006302,biological_process double-strand break repair;GO:0007143,biological_process female meiotic division;GO:0010468,biological_process regulation of gene expression;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048477,biological_process oogenesis;GO:0051321,biological_process meiotic cell cycle	NA	meiosis regulator and mRNA stability factor 1 [Source:HGNC Symbol%3BAcc:HGNC:29562]
ENSG00000204839	1.38	1.22	1.78	1.60	1.42	1.73	-0.0931194178733501	1.81491671038028	0.667215210286038	0.902562222935504	8:143566186-143572971:-	MROH6	NA	NA	maestro heat like repeat family member 6 [Source:HGNC Symbol%3BAcc:HGNC:27814]
ENSG00000066468	9.56	13.66	8.87	8.70	13.18	8.84	0.0708669048363998	4.9810946300905	0.667256446667098	0.902562222935504	10:121478333-121598458:-	FGFR2	141;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001657,biological_process ureteric bud development;GO:0001701,biological_process in utero embryonic development;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003149,biological_process membranous septum morphogenesis;GO:0003416,biological_process endochondral bone growth;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005007,molecular_function fibroblast growth factor-activated receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007267,biological_process cell-cell signaling;GO:0007409,biological_process axonogenesis;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0009791,biological_process post-embryonic development;GO:0009880,biological_process embryonic pattern specification;GO:0009887,biological_process organ morphogenesis;GO:0009986,cellular_component cell surface;GO:0010453,biological_process regulation of cell fate commitment;GO:0010518,biological_process positive regulation of phospholipase activity;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0016740,molecular_function transferase activity;GO:0017134,molecular_function fibroblast growth factor binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021769,biological_process orbitofrontal cortex development;GO:0021847,biological_process ventricular zone neuroblast division;GO:0021860,biological_process pyramidal neuron development;GO:0022612,biological_process gland morphogenesis;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030282,biological_process bone mineralization;GO:0030324,biological_process lung development;GO:0030855,biological_process epithelial cell differentiation;GO:0030901,biological_process midbrain development;GO:0030916,biological_process otic vesicle formation;GO:0031012,cellular_component extracellular matrix;GO:0031069,biological_process hair follicle morphogenesis;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032496,biological_process response to lipopolysaccharide;GO:0032808,biological_process lacrimal gland development;GO:0033688,biological_process regulation of osteoblast proliferation;GO:0035264,biological_process multicellular organism growth;GO:0035265,biological_process organ growth;GO:0035602,biological_process fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow;GO:0035603,biological_process fibroblast growth factor receptor signaling pathway involved in hemopoiesis;GO:0035604,biological_process fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow;GO:0035607,biological_process fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0040014,biological_process regulation of multicellular organism growth;GO:0040036,biological_process regulation of fibroblast growth factor receptor signaling pathway;GO:0042060,biological_process wound healing;GO:0042472,biological_process inner ear morphogenesis;GO:0042476,biological_process odontogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045165,biological_process cell fate commitment;GO:0045471,biological_process response to ethanol;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0045787,biological_process positive regulation of cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048286,biological_process lung alveolus development;GO:0048333,biological_process mesodermal cell differentiation;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048562,biological_process embryonic organ morphogenesis;GO:0048565,biological_process digestive tract development;GO:0048568,biological_process embryonic organ development;GO:0048608,biological_process reproductive structure development;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0048730,biological_process epidermis morphogenesis;GO:0048755,biological_process branching morphogenesis of a nerve;GO:0048762,biological_process mesenchymal cell differentiation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051150,biological_process regulation of smooth muscle cell differentiation;GO:0051781,biological_process positive regulation of cell division;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060076,cellular_component excitatory synapse;GO:0060174,biological_process limb bud formation;GO:0060348,biological_process bone development;GO:0060349,biological_process bone morphogenesis;GO:0060442,biological_process branching involved in prostate gland morphogenesis;GO:0060445,biological_process branching involved in salivary gland morphogenesis;GO:0060449,biological_process bud elongation involved in lung branching;GO:0060463,biological_process lung lobe morphogenesis;GO:0060484,biological_process lung-associated mesenchyme development;GO:0060501,biological_process positive regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0060512,biological_process prostate gland morphogenesis;GO:0060523,biological_process prostate epithelial cord elongation;GO:0060527,biological_process prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0060529,biological_process squamous basal epithelial stem cell differentiation involved in prostate gland acinus development;GO:0060595,biological_process fibroblast growth factor receptor signaling pathway involved in mammary gland specification;GO:0060601,biological_process lateral sprouting from an epithelium;GO:0060615,biological_process mammary gland bud formation;GO:0060664,biological_process epithelial cell proliferation involved in salivary gland morphogenesis;GO:0060667,biological_process branch elongation involved in salivary gland morphogenesis;GO:0060670,biological_process branching involved in labyrinthine layer morphogenesis;GO:0060687,biological_process regulation of branching involved in prostate gland morphogenesis;GO:0060688,biological_process regulation of morphogenesis of a branching structure;GO:0060915,biological_process mesenchymal cell differentiation involved in lung development;GO:0060916,biological_process mesenchymal cell proliferation involved in lung development;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071300,biological_process cellular response to retinoic acid;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]; K05093	fibroblast growth factor receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:3689]
ENSG00000135999	8.27	7.04	7.64	7.60	7.67	8.58	-0.03870324666544	4.40567451927274	0.667503371208129	0.902562222935504	2:148644439-148787568:+	EPC2	11;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0032777,cellular_component Piccolo NuA4 histone acetyltransferase complex;GO:0035267,cellular_component NuA4 histone acetyltransferase complex	NA	enhancer of polycomb homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:24543]
ENSG00000145916	7.73	8.29	7.62	8.41	8.80	7.54	-0.056847530928801	3.48475244814704	0.667545405626062	0.902562222935504	5:178130995-178150565:+	RMND5B	6;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0034657,cellular_component GID complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	NA	required for meiotic nuclear division 5 homolog B [Source:HGNC Symbol%3BAcc:HGNC:26181]
ENSG00000121417	7.25	7.11	8.20	7.10	7.30	7.66	0.0465883466954323	3.95141981219986	0.667669400710647	0.902562222935504	19:57630394-57642779:+	ZNF211	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 211 [Source:HGNC Symbol%3BAcc:HGNC:13003]
ENSG00000175879	18.51	15.71	19.63	20.48	15.26	20.85	-0.0548931945530706	4.02205650845517	0.667736463725785	0.902562222935504	2:176129693-176132695:+	HOXD8	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008595,biological_process anterior/posterior axis specification, embryo;GO:0009952,biological_process anterior/posterior pattern specification;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048705,biological_process skeletal system morphogenesis	NA	homeobox D8 [Source:HGNC Symbol%3BAcc:HGNC:5139]
ENSG00000102595	8.25	8.00	8.98	8.47	8.39	8.03	0.0343551614255947	5.28909818946209	0.667737374232954	0.902562222935504	13:95801579-96053482:-	UGGT2	17;GO:0003980,molecular_function UDP-glucose:glycoprotein glucosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006486,biological_process protein glycosylation;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0043234,cellular_component protein complex;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0051082,molecular_function unfolded protein binding;GO:0051084,biological_process 'de novo' posttranslational protein folding;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:0097359,biological_process UDP-glucosylation;GO:1904380,biological_process endoplasmic reticulum mannose trimming	HUGT; UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-]; K11718	UDP-glucose glycoprotein glucosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:15664]
ENSG00000178607	3.77	2.45	3.39	3.32	2.85	4.08	-0.071342899457747	3.38874039501414	0.667739488312348	0.902562222935504	17:64039141-64130819:-	ERN1	64;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001935,biological_process endothelial cell proliferation;GO:0003824,molecular_function catalytic activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005637,cellular_component nuclear inner membrane;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006379,biological_process mRNA cleavage;GO:0006397,biological_process mRNA processing;GO:0006402,biological_process mRNA catabolic process;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006986,biological_process response to unfolded protein;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0007050,biological_process cell cycle arrest;GO:0007257,biological_process activation of JUN kinase activity;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030544,molecular_function Hsp70 protein binding;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0033120,biological_process positive regulation of RNA splicing;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0036289,biological_process peptidyl-serine autophosphorylation;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043531,molecular_function ADP binding;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051879,molecular_function Hsp90 protein binding;GO:0070054,biological_process mRNA splicing, via endonucleolytic cleavage and ligation;GO:0070055,biological_process mRNA endonucleolytic cleavage involved in unfolded protein response;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071333,biological_process cellular response to glucose stimulus;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:1900103,biological_process positive regulation of endoplasmic reticulum unfolded protein response;GO:1901142,biological_process insulin metabolic process;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1990332,cellular_component Ire1 complex;GO:1990579,biological_process peptidyl-serine trans-autophosphorylation;GO:1990597,cellular_component AIP1-IRE1 complex;GO:1990604,cellular_component IRE1-TRAF2-ASK1 complex;GO:1990630,cellular_component IRE1-RACK1-PP2A complex	ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]; K08852	endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol%3BAcc:HGNC:3449]
ENSG00000243660	4.02	3.66	3.09	3.61	3.28	3.30	0.091333633950558	1.57389707161416	0.667772241304018	0.902562222935504	10:43436840-43483179:+	ZNF487	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 487 [Source:HGNC Symbol%3BAcc:HGNC:23488]
ENSG00000130638	96.51	102.39	92.08	99.50	99.84	99.56	-0.028216499016681	7.37045590751399	0.667789069967564	0.902562222935504	22:45671797-45845307:+	ATXN10	15;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0019899,molecular_function enzyme binding;GO:0030425,cellular_component dendrite;GO:0031175,biological_process neuron projection development;GO:0042802,molecular_function identical protein binding;GO:0043025,cellular_component neuronal cell body;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060271,biological_process cilium morphogenesis;GO:0070207,biological_process protein homotrimerization	NA	ataxin 10 [Source:HGNC Symbol%3BAcc:HGNC:10549]
ENSG00000162604	34.59	34.33	32.98	35.29	32.87	32.29	0.0324198843371543	5.1931336909523	0.667873458095009	0.902562222935504	1:61681045-61725423:-	TM2D1	8;GO:0001540,molecular_function beta-amyloid binding;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0097190,biological_process apoptotic signaling pathway	NA	TM2 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24142]
ENSG00000103522	3.11	3.02	3.51	3.43	2.54	3.22	0.0824079081470533	2.3867861041149	0.667891604233113	0.902562222935504	16:27402161-27452042:+	IL21R	7;GO:0001532,molecular_function interleukin-21 receptor activity;GO:0004896,molecular_function cytokine receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030101,biological_process natural killer cell activation;GO:0038114,biological_process interleukin-21-mediated signaling pathway	IL21R, CD360; interleukin 21 receptor; K05075	interleukin 21 receptor [Source:HGNC Symbol%3BAcc:HGNC:6006]
ENSG00000109332	275.51	291.04	295.12	298.76	309.65	277.73	-0.0288395114650646	7.48939782287601	0.668031260716103	0.902562222935504	4:102794382-102868896:-	UBE2D3	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030509,biological_process BMP signaling pathway;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865,biological_process protein autoubiquitination;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070062,cellular_component extracellular exosome;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol%3BAcc:HGNC:12476]
ENSG00000110911	14.57	16.08	15.86	16.06	16.65	15.30	-0.0365701628483315	4.94697281669179	0.668055917733629	0.902562222935504	12:50979400-51028566:-	SLC11A2	65;GO:0005215,molecular_function transporter activity;GO:0005375,molecular_function copper ion transmembrane transporter activity;GO:0005381,molecular_function iron ion transmembrane transporter activity;GO:0005384,molecular_function manganese ion transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005773,cellular_component vacuole;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005903,cellular_component brush border;GO:0006778,biological_process porphyrin-containing compound metabolic process;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006824,biological_process cobalt ion transport;GO:0006825,biological_process copper ion transport;GO:0006826,biological_process iron ion transport;GO:0006828,biological_process manganese ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007611,biological_process learning or memory;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0010039,biological_process response to iron ion;GO:0012505,cellular_component endomembrane system;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015086,molecular_function cadmium ion transmembrane transporter activity;GO:0015087,molecular_function cobalt ion transmembrane transporter activity;GO:0015093,molecular_function ferrous iron transmembrane transporter activity;GO:0015094,molecular_function lead ion transmembrane transporter activity;GO:0015295,molecular_function solute:proton symporter activity;GO:0015639,molecular_function ferrous iron uptake transmembrane transporter activity;GO:0015684,biological_process ferrous iron transport;GO:0015692,biological_process lead ion transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031526,cellular_component brush border membrane;GO:0031902,cellular_component late endosome membrane;GO:0034755,biological_process iron ion transmembrane transport;GO:0035434,biological_process copper ion transmembrane transport;GO:0045177,cellular_component apical part of cell;GO:0045178,cellular_component basal part of cell;GO:0046870,molecular_function cadmium ion binding;GO:0046915,molecular_function transition metal ion transmembrane transporter activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048813,biological_process dendrite morphogenesis;GO:0048821,biological_process erythrocyte development;GO:0055037,cellular_component recycling endosome;GO:0055072,biological_process iron ion homeostasis;GO:0060586,biological_process multicellular organismal iron ion homeostasis;GO:0070574,biological_process cadmium ion transmembrane transport;GO:0070627,biological_process ferrous iron import;GO:0070826,cellular_component paraferritin complex;GO:0071421,biological_process manganese ion transmembrane transport;GO:1902600,biological_process hydrogen ion transmembrane transport;GO:1903874,biological_process ferrous iron transmembrane transport	SLC11A1, NRAMP1; natural resistance-associated macrophage protein 1; K12347	solute carrier family 11 member 2 [Source:HGNC Symbol%3BAcc:HGNC:10908]
ENSG00000233276	364.95	370.52	345.62	361.82	354.05	354.40	0.0258218403708179	7.8685273831171	0.668092813431192	0.902562222935504	3:49357175-49358600:-	GPX1	60;GO:0000302,biological_process response to reactive oxygen species;GO:0001659,biological_process temperature homeostasis;GO:0001885,biological_process endothelial cell development;GO:0002862,biological_process negative regulation of inflammatory response to antigenic stimulus;GO:0004601,molecular_function peroxidase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006195,biological_process purine nucleotide catabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006749,biological_process glutathione metabolic process;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0007605,biological_process sensory perception of sound;GO:0008283,biological_process cell proliferation;GO:0008631,biological_process intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0009410,biological_process response to xenobiotic stimulus;GO:0009609,biological_process response to symbiotic bacterium;GO:0009611,biological_process response to wounding;GO:0009636,biological_process response to toxic substance;GO:0009650,biological_process UV protection;GO:0010269,biological_process response to selenium ion;GO:0010332,biological_process response to gamma radiation;GO:0014902,biological_process myotube differentiation;GO:0016491,molecular_function oxidoreductase activity;GO:0017124,molecular_function SH3 domain binding;GO:0018158,biological_process protein oxidation;GO:0019372,biological_process lipoxygenase pathway;GO:0033194,biological_process response to hydroperoxide;GO:0033599,biological_process regulation of mammary gland epithelial cell proliferation;GO:0034599,biological_process cellular response to oxidative stress;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042311,biological_process vasodilation;GO:0042542,biological_process response to hydrogen peroxide;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043534,biological_process blood vessel endothelial cell migration;GO:0045444,biological_process fat cell differentiation;GO:0045454,biological_process cell redox homeostasis;GO:0048741,biological_process skeletal muscle fiber development;GO:0051450,biological_process myoblast proliferation;GO:0051702,biological_process interaction with symbiont;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0055114,biological_process oxidation-reduction process;GO:0060047,biological_process heart contraction;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097413,cellular_component Lewy body;GO:0098869,biological_process cellular oxidant detoxification;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1902905,biological_process positive regulation of fibril organization	gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9]; K00432	glutathione peroxidase 1 [Source:HGNC Symbol%3BAcc:HGNC:4553]
ENSG00000125375	11.11	13.08	13.29	11.64	12.29	12.51	0.0469642225396806	3.74038258891289	0.668141808310187	0.902562222935504	14:50312325-50335558:+	ATP5S	12;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046872,molecular_function metal ion binding	NA	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit s (factor B) [Source:HGNC Symbol%3BAcc:HGNC:18799]
ENSG00000183691	15.02	13.32	15.33	18.18	11.55	16.47	-0.066057648453862	3.40928719841713	0.668294844146079	0.902670718213849	17:56593698-56595590:+	NOG	79;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001501,biological_process skeletal system development;GO:0001649,biological_process osteoblast differentiation;GO:0001655,biological_process urogenital system development;GO:0001657,biological_process ureteric bud development;GO:0001701,biological_process in utero embryonic development;GO:0001706,biological_process endoderm formation;GO:0001707,biological_process mesoderm formation;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001839,biological_process neural plate morphogenesis;GO:0001843,biological_process neural tube closure;GO:0003149,biological_process membranous septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003223,biological_process ventricular compact myocardium morphogenesis;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0007492,biological_process endoderm development;GO:0008045,biological_process motor neuron axon guidance;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0019955,molecular_function cytokine binding;GO:0021510,biological_process spinal cord development;GO:0021533,biological_process cell differentiation in hindbrain;GO:0021915,biological_process neural tube development;GO:0021983,biological_process pituitary gland development;GO:0030154,biological_process cell differentiation;GO:0030336,biological_process negative regulation of cell migration;GO:0030509,biological_process BMP signaling pathway;GO:0030510,biological_process regulation of BMP signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042060,biological_process wound healing;GO:0042474,biological_process middle ear morphogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0045596,biological_process negative regulation of cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048318,biological_process axial mesoderm development;GO:0048570,biological_process notochord morphogenesis;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0048712,biological_process negative regulation of astrocyte differentiation;GO:0048762,biological_process mesenchymal cell differentiation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051216,biological_process cartilage development;GO:0055009,biological_process atrial cardiac muscle tissue morphogenesis;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:0060173,biological_process limb development;GO:0060272,biological_process embryonic skeletal joint morphogenesis;GO:0060302,biological_process negative regulation of cytokine activity;GO:0060325,biological_process face morphogenesis;GO:0060394,biological_process negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060425,biological_process lung morphogenesis;GO:0060513,biological_process prostatic bud formation;GO:0060676,biological_process ureteric bud formation;GO:0060825,biological_process fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0061037,biological_process negative regulation of cartilage development;GO:0061053,biological_process somite development;GO:0061312,biological_process BMP signaling pathway involved in heart development;GO:0061384,biological_process heart trabecula morphogenesis;GO:0061626,biological_process pharyngeal arch artery morphogenesis;GO:0071773,biological_process cellular response to BMP stimulus;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0090193,biological_process positive regulation of glomerulus development;GO:1905006,biological_process negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:2000313,biological_process regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	NA	noggin [Source:HGNC Symbol%3BAcc:HGNC:7866]
ENSG00000198324	2.97	3.53	2.81	3.33	2.61	4.20	-0.132856829350687	1.4319083255814	0.668464199356527	0.902801230183067	12:111360650-111369121:-	FAM109A	13;GO:0001881,biological_process receptor recycling;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0007032,biological_process endosome organization;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042803,molecular_function protein homodimerization activity;GO:0055037,cellular_component recycling endosome	NA	family with sequence similarity 109 member A [Source:HGNC Symbol%3BAcc:HGNC:26509]
ENSG00000197714	3.77	3.00	3.49	4.13	3.24	3.59	-0.0699729907610459	2.62050000087482	0.668588393698222	0.902853690629968	19:57280050-57293569:+	ZNF460	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 460 [Source:HGNC Symbol%3BAcc:HGNC:21628]
ENSG00000243896	2.05	1.75	2.53	2.09	2.53	2.42	-0.125002703796394	1.16407769619614	0.66870087674346	0.902853690629968	7:144257662-144264792:-	OR2A7	13;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004984,molecular_function olfactory receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007608,biological_process sensory perception of smell;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050896,biological_process response to stimulus;GO:0050907,biological_process detection of chemical stimulus involved in sensory perception;GO:0050911,biological_process detection of chemical stimulus involved in sensory perception of smell	OLFR; olfactory receptor; K04257	olfactory receptor family 2 subfamily A member 7 [Source:HGNC Symbol%3BAcc:HGNC:8234]
ENSG00000112182	0.28	0.83	0.44	0.53	0.39	0.42	0.159975423234151	0.413414964293151	0.668765515283705	0.902853690629968	6:89926528-90296908:-	BACH2	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001206,molecular_function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:1902593,biological_process single-organism nuclear import	NA	BTB domain and CNC homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:14078]
ENSG00000143486	39.35	39.29	41.75	41.47	37.92	39.61	0.0290927062795443	6.17048464195795	0.66879398093471	0.902853690629968	1:206571291-206612463:-	EIF2D	13;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0004872,molecular_function receptor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006886,biological_process intracellular protein transport;GO:0016604,cellular_component nuclear body;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0032790,biological_process ribosome disassembly;GO:0075522,biological_process IRES-dependent viral translational initiation	NA	eukaryotic translation initiation factor 2D [Source:HGNC Symbol%3BAcc:HGNC:6583]
ENSG00000112167	7.76	12.74	11.80	10.52	10.25	13.68	-0.0966432379216827	2.65569453489295	0.668930220470926	0.902870584428668	6:39104063-39115189:-	SAYSD1	5;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	SAYSVFN motif domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21025]
ENSG00000271601	33.95	31.48	30.50	33.55	33.91	31.65	-0.0328709388111845	5.04651078171597	0.668964667896512	0.902870584428668	1:145933422-145958001:-	LIX1L	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0097352,biological_process autophagosome maturation	LIX1L; LIX1-like protein; K16673	limb and CNS expressed 1 like [Source:HGNC Symbol%3BAcc:HGNC:28715]
ENSG00000228474	863.42	902.28	883.88	901.16	952.47	870.42	-0.0287897511796265	6.63813177343533	0.669024702777321	0.902870584428668	2:27070471-27071773:-	OST4	7;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine	NA	oligosaccharyltransferase complex subunit 4%2C non-catalytic [Source:HGNC Symbol%3BAcc:HGNC:32483]
ENSG00000131469	949.04	927.32	946.43	965.53	955.55	972.66	-0.0239206878891403	8.865309550978	0.669303690327083	0.902944691764719	17:42998272-43002959:+	RPL27	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	RP-L27e, RPL27; large subunit ribosomal protein L27e; K02901	ribosomal protein L27 [Source:HGNC Symbol%3BAcc:HGNC:10328]
ENSG00000184619	2.49	3.63	2.79	2.23	2.77	3.33	0.0839842004535012	2.12512979168939	0.669338015019184	0.902944691764719	17:8368636-8376711:-	KRBA2	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0015074,biological_process DNA integration	NA	KRAB-A domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26989]
ENSG00000205464	8.51	4.84	4.93	5.91	4.63	6.59	0.118131151020041	2.05684457523272	0.669368354989225	0.902944691764719	5:82279461-82386977:+	ATP6AP1L	6;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033180,cellular_component proton-transporting V-type ATPase, V1 domain;GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism	NA	ATPase H+ transporting accessory protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:28091]
ENSG00000111644	0.77	0.87	1.17	0.82	0.88	0.86	0.153230922659219	0.697291741660158	0.669370583551031	0.902944691764719	12:6638074-6647460:-	ACRBP	8;GO:0001669,cellular_component acrosomal vesicle;GO:0002080,cellular_component acrosomal membrane;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048240,biological_process sperm capacitation	NA	acrosin binding protein [Source:HGNC Symbol%3BAcc:HGNC:17195]
ENSG00000069275	244.33	247.50	237.46	249.98	248.33	249.92	-0.0256649740578776	7.49004921234093	0.66969440307204	0.903283345141067	1:205712818-205750276:-	NUCKS1	31;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001678,biological_process cellular glucose homeostasis;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006275,biological_process regulation of DNA replication;GO:0006325,biological_process chromatin organization;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0019046,biological_process release from viral latency;GO:0031297,biological_process replication fork processing;GO:0035822,biological_process gene conversion;GO:0036297,biological_process interstrand cross-link repair;GO:0042593,biological_process glucose homeostasis;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0044829,biological_process positive regulation by host of viral genome replication;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0060382,biological_process regulation of DNA strand elongation;GO:0071481,biological_process cellular response to X-ray;GO:1990968,biological_process modulation by host of RNA binding by virus;GO:1990969,biological_process modulation by host of viral RNA-binding transcription factor activity	NA	nuclear casein kinase and cyclin dependent kinase substrate 1 [Source:HGNC Symbol%3BAcc:HGNC:29923]
ENSG00000184076	289.10	357.63	281.32	286.51	335.39	286.59	0.0391655831573917	6.10669128825646	0.670186670087688	0.903849102107613	22:29767368-29770413:+	UQCR10	12;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	QCR9, UCRC; ubiquinol-cytochrome c reductase subunit 9; K00419	ubiquinol-cytochrome c reductase%2C complex III subunit X [Source:HGNC Symbol%3BAcc:HGNC:30863]
ENSG00000138162	2.27	2.01	2.11	2.39	1.99	2.25	-0.0409317115866268	4.38077647127033	0.670305779816001	0.903888184527353	10:121989173-122254545:+	TACC2	12;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0008283,biological_process cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0021987,biological_process cerebral cortex development;GO:0035257,molecular_function nuclear hormone receptor binding	NA	transforming acidic coiled-coil containing protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11523]
ENSG00000100196	61.11	77.36	63.48	63.82	65.95	68.10	0.0347130861464027	5.54148330570467	0.670361284682092	0.903888184527353	22:38468061-38483447:+	KDELR3	13;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006621,biological_process protein retention in ER lumen;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0046923,molecular_function ER retention sequence binding	KDELR; ER lumen protein retaining receptor; K10949	KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:6306]
ENSG00000123144	135.91	149.75	142.40	137.39	139.83	145.59	0.0271890951831811	6.36965436162718	0.670468634328093	0.903934740731467	19:12730639-12734775:-	TRIR	1;GO:0005515,molecular_function protein binding	NA	telomerase RNA component interacting RNase [Source:HGNC Symbol%3BAcc:HGNC:28424]
ENSG00000167703	1.61	1.11	1.09	1.27	1.45	0.82	0.141109302687541	1.30445314595381	0.670568063152562	0.903961956318572	17:1569266-1628886:-	SLC43A2	14;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015179,molecular_function L-amino acid transmembrane transporter activity;GO:0015804,biological_process neutral amino acid transport;GO:0015807,biological_process L-amino acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:1902475,biological_process L-alpha-amino acid transmembrane transport	NA	solute carrier family 43 member 2 [Source:HGNC Symbol%3BAcc:HGNC:23087]
ENSG00000127946	12.36	12.01	12.95	12.95	11.87	11.99	0.0332725575654862	5.28648150291933	0.670689858327592	0.903961956318572	7:75533299-75738962:-	HIP1	53;GO:0003779,molecular_function actin binding;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007010,biological_process cytoskeleton organization;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0030100,biological_process regulation of endocytosis;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030154,biological_process cell differentiation;GO:0030276,molecular_function clathrin binding;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032051,molecular_function clathrin light chain binding;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035254,molecular_function glutamate receptor binding;GO:0035612,molecular_function AP-2 adaptor complex binding;GO:0035615,molecular_function clathrin adaptor activity;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0046982,molecular_function protein heterodimerization activity;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0048268,biological_process clathrin coat assembly;GO:0050821,biological_process protein stabilization;GO:0051015,molecular_function actin filament binding;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:0097190,biological_process apoptotic signaling pathway;GO:0098793,cellular_component presynapse;GO:0098794,cellular_component postsynapse;GO:0098888,cellular_component extrinsic component of presynaptic membrane;GO:0098890,cellular_component extrinsic component of postsynaptic membrane;GO:0099637,biological_process neurotransmitter receptor transport;GO:2000588,biological_process positive regulation of platelet-derived growth factor receptor-beta signaling pathway	HIP1; huntingtin interacting protein 1; K04559	huntingtin interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4913]
ENSG00000182979	56.23	50.63	56.31	56.68	52.11	59.32	-0.0298361980753251	6.93982159445761	0.67070729216902	0.903961956318572	14:105419819-105470729:+	MTA1	36;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006302,biological_process double-strand break repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0010212,biological_process response to ionizing radiation;GO:0016575,biological_process histone deacetylation;GO:0016925,biological_process protein sumoylation;GO:0032922,biological_process circadian regulation of gene expression;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045475,biological_process locomotor rhythm;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:1902499,biological_process positive regulation of protein autoubiquitination;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	metastasis associated 1 [Source:HGNC Symbol%3BAcc:HGNC:7410]
ENSG00000102753	11.60	10.01	10.58	9.42	11.39	10.69	0.0485692078392753	4.07083391611224	0.671028779606862	0.904146659602514	13:49699306-49792921:-	KPNA3	20;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006461,biological_process protein complex assembly;GO:0006606,biological_process protein import into nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0008022,molecular_function protein C-terminus binding;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0019054,biological_process modulation by virus of host process;GO:0043657,cellular_component host cell;GO:0046718,biological_process viral entry into host cell;GO:0075732,biological_process viral penetration into host nucleus;GO:0075733,biological_process intracellular transport of virus	NA	karyopherin subunit alpha 3 [Source:HGNC Symbol%3BAcc:HGNC:6396]
ENSG00000149483	26.08	23.84	27.62	24.21	24.68	26.81	0.0518670640034184	3.69857989851459	0.671045834877197	0.904146659602514	11:61362000-61369509:+	TMEM138	8;GO:0005773,cellular_component vacuole;GO:0005774,cellular_component vacuolar membrane;GO:0005929,cellular_component cilium;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	transmembrane protein 138 [Source:HGNC Symbol%3BAcc:HGNC:26944]
ENSG00000167550	4.83	4.86	4.33	5.12	3.98	4.02	0.104716590111755	1.58034880565098	0.671062851439456	0.904146659602514	12:49064684-49070025:-	RHEBL1	11;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0031929,biological_process TOR signaling;GO:0046872,molecular_function metal ion binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	NA	Ras homolog enriched in brain like 1 [Source:HGNC Symbol%3BAcc:HGNC:21166]
ENSG00000133316	27.46	25.74	26.86	30.22	24.68	27.98	-0.0364129154001448	5.05192988849142	0.671380932630504	0.904477047616935	11:62832341-62841809:-	WDR74	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008150,biological_process biological_process;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0042273,biological_process ribosomal large subunit biogenesis	NA	WD repeat domain 74 [Source:HGNC Symbol%3BAcc:HGNC:25529]
ENSG00000213930	12.79	8.65	9.01	10.92	9.66	8.78	0.0733939435068496	3.59715553753342	0.671680343564395	0.904780829300078	9:34638132-34651035:+	GALT	15;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006011,biological_process UDP-glucose metabolic process;GO:0006012,biological_process galactose metabolic process;GO:0006258,biological_process UDP-glucose catabolic process;GO:0008108,molecular_function UDP-glucose:hexose-1-phosphate uridylyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019388,biological_process galactose catabolic process;GO:0033499,biological_process galactose catabolic process via UDP-galactose;GO:0046872,molecular_function metal ion binding	galT, GALT; UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]; K00965	galactose-1-phosphate uridylyltransferase [Source:HGNC Symbol%3BAcc:HGNC:4135]
ENSG00000040199	2.35	2.69	2.59	2.37	2.28	2.74	0.0506736173980054	3.43443962467691	0.671752205174375	0.904780829300078	16:71637834-71724701:-	PHLPP2	15;GO:0001917,cellular_component photoreceptor inner segment;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0021766,biological_process hippocampus development;GO:0042622,cellular_component photoreceptor outer segment membrane;GO:0046872,molecular_function metal ion binding	PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]; K16340	PH domain and leucine rich repeat protein phosphatase 2 [Source:HGNC Symbol%3BAcc:HGNC:29149]
ENSG00000100300	195.02	175.67	190.17	193.01	168.29	192.23	0.0321667559176893	6.56131839678521	0.671930482015489	0.904813007259754	22:43151513-43163242:+	TSPO	59;GO:0005497,molecular_function androgen binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006694,biological_process steroid biosynthetic process;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0006821,biological_process chloride transport;GO:0006869,biological_process lipid transport;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007568,biological_process aging;GO:0008202,biological_process steroid metabolic process;GO:0008283,biological_process cell proliferation;GO:0008347,biological_process glial cell migration;GO:0008503,molecular_function benzodiazepine receptor activity;GO:0010042,biological_process response to manganese ion;GO:0010266,biological_process response to vitamin B1;GO:0010823,biological_process negative regulation of mitochondrion organization;GO:0010940,biological_process positive regulation of necrotic cell death;GO:0014012,biological_process peripheral nervous system axon regeneration;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017127,molecular_function cholesterol transporter activity;GO:0030301,biological_process cholesterol transport;GO:0030325,biological_process adrenal gland development;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031966,cellular_component mitochondrial membrane;GO:0032374,biological_process regulation of cholesterol transport;GO:0032570,biological_process response to progesterone;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0033574,biological_process response to testosterone;GO:0042493,biological_process response to drug;GO:0043065,biological_process positive regulation of apoptotic process;GO:0044325,molecular_function ion channel binding;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0048265,biological_process response to pain;GO:0048266,biological_process behavioral response to pain;GO:0048678,biological_process response to axon injury;GO:0050810,biological_process regulation of steroid biosynthetic process;GO:0051901,biological_process positive regulation of mitochondrial depolarization;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0060242,biological_process contact inhibition;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0060253,biological_process negative regulation of glial cell proliferation;GO:0070062,cellular_component extracellular exosome;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071294,biological_process cellular response to zinc ion;GO:0071476,biological_process cellular hypotonic response;GO:0072655,biological_process establishment of protein localization to mitochondrion;GO:0072656,biological_process maintenance of protein location in mitochondrion;GO:1903147,biological_process negative regulation of mitophagy;GO:1903579,biological_process negative regulation of ATP metabolic process;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process	TSPO, BZRP; translocator protein; K05770	translocator protein [Source:HGNC Symbol%3BAcc:HGNC:1158]
ENSG00000117877	17.10	15.62	16.48	16.28	15.55	16.62	0.0375059299081321	4.6550825128762	0.671957659348596	0.904813007259754	19:45406208-45410766:+	CD3EAP	17;GO:0000120,cellular_component RNA polymerase I transcription factor complex;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009303,biological_process rRNA transcription;GO:0045815,biological_process positive regulation of gene expression, epigenetic	NA	CD3e molecule associated protein [Source:HGNC Symbol%3BAcc:HGNC:24219]
ENSG00000171448	5.07	5.35	5.95	5.49	6.42	5.37	-0.0635726490881832	2.92140187653619	0.672043539734285	0.904813007259754	9:122915565-122931500:-	ZBTB26	11;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 26 [Source:HGNC Symbol%3BAcc:HGNC:23383]
ENSG00000170545	15.09	19.67	16.12	21.34	13.41	19.48	-0.0926426848659354	2.75910696949201	0.672068563817248	0.904813007259754	12:51244557-51270890:-	SMAGP	17;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008037,biological_process cell recognition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042803,molecular_function protein homodimerization activity;GO:0050839,molecular_function cell adhesion molecule binding	NA	small cell adhesion glycoprotein [Source:HGNC Symbol%3BAcc:HGNC:26918]
ENSG00000100109	25.72	22.53	25.22	26.41	24.11	25.22	-0.0289738138902192	5.99496302337568	0.672227768853085	0.904813007259754	22:26491224-26512505:-	TFIP11	25;GO:0000390,biological_process spliceosomal complex disassembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031214,biological_process biomineral tissue development;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031848,biological_process protection from non-homologous end joining at telomere;GO:0032091,biological_process negative regulation of protein binding;GO:0071008,cellular_component U2-type post-mRNA release spliceosomal complex;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1904876,biological_process negative regulation of DNA ligase activity;GO:2001033,biological_process negative regulation of double-strand break repair via nonhomologous end joining	NA	tuftelin interacting protein 11 [Source:HGNC Symbol%3BAcc:HGNC:17165]
ENSG00000114742	20.74	19.07	20.66	20.47	21.54	20.35	-0.0287550538995956	5.41261550111394	0.672258946410841	0.904813007259754	3:39051997-39096671:+	WDR48	24;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0008584,biological_process male gonad development;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0035264,biological_process multicellular organism growth;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043588,biological_process skin development;GO:0048568,biological_process embryonic organ development;GO:0048705,biological_process skeletal system morphogenesis;GO:0048872,biological_process homeostasis of number of cells;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0072520,biological_process seminiferous tubule development;GO:1902525,biological_process regulation of protein monoubiquitination	WDR48, UAF1; WD repeat-containing protein 48; K15361	WD repeat domain 48 [Source:HGNC Symbol%3BAcc:HGNC:30914]
ENSG00000159761	0.70	0.77	1.19	0.60	1.09	0.63	0.218230220820742	0.106755646958104	0.672343546511552	0.904813007259754	16:67666815-67668758:+	C16orf86	NA	NA	chromosome 16 open reading frame 86 [Source:HGNC Symbol%3BAcc:HGNC:33755]
ENSG00000107443	3.38	4.24	3.40	3.39	4.36	3.98	-0.093322881385047	2.16591540392652	0.672406306012742	0.904813007259754	10:96043393-96060870:+	CCNJ	1;GO:0005634,cellular_component nucleus	NA	cyclin J [Source:HGNC Symbol%3BAcc:HGNC:23434]
ENSG00000189157	0.29	0.77	0.55	0.86	0.31	0.71	-0.26595648455975	0.00158642946398272	0.672432126961349	0.904813007259754	4:76214039-76283780:+	FAM47E	3;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process	NA	family with sequence similarity 47 member E [Source:HGNC Symbol%3BAcc:HGNC:34343]
ENSG00000186184	42.06	46.41	40.89	47.67	44.31	41.52	-0.0377437730911572	5.13803796682368	0.672711571484201	0.905090910127182	13:27620741-27744237:+	POLR1D	18;GO:0001054,molecular_function RNA polymerase I activity;GO:0001056,molecular_function RNA polymerase III activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0032481,biological_process positive regulation of type I interferon production;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046983,molecular_function protein dimerization activity	RPC19, POLR1D; DNA-directed RNA polymerases I and III subunit RPAC2; K03020	RNA polymerase I subunit D [Source:HGNC Symbol%3BAcc:HGNC:20422]
ENSG00000166793	2.97	2.01	3.09	2.75	1.79	2.77	0.17384499562227	0.18851817122098	0.672947882782026	0.905310726018564	11:57645086-57649944:-	YPEL4	3;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0046872,molecular_function metal ion binding	NA	yippee like 4 [Source:HGNC Symbol%3BAcc:HGNC:18328]
ENSG00000169570	3.55	4.81	3.38	5.16	3.49	3.92	-0.105091716173462	1.93712268316482	0.673037589788753	0.905333290208906	5:118837321-118988545:-	DTWD2	1;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	DTW domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:19334]
ENSG00000089876	31.30	29.37	30.81	31.47	29.40	33.28	-0.0286896867604084	6.11280373078412	0.67315497062912	0.905393070800657	10:125836336-125896436:-	DHX32	12;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0016787,molecular_function hydrolase activity	NA	DEAH-box helicase 32 (putative) [Source:HGNC Symbol%3BAcc:HGNC:16717]
ENSG00000125901	33.42	31.70	30.16	28.85	30.58	33.84	0.0413609238392615	4.28529660653852	0.673271994587673	0.905452358485026	20:3045944-3048254:+	MRPS26	11;GO:0003723,molecular_function RNA binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043043,biological_process peptide biosynthetic process;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S26 [Source:HGNC Symbol%3BAcc:HGNC:14045]
ENSG00000163935	8.89	8.35	9.15	8.30	8.70	8.99	0.0374675209404051	4.51534814174153	0.673570214382605	0.905696708454492	3:52903571-53046750:-	SFMBT1	12;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007283,biological_process spermatogenesis;GO:0016569,biological_process covalent chromatin modification;GO:0030154,biological_process cell differentiation;GO:0042393,molecular_function histone binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048635,biological_process negative regulation of muscle organ development	NA	Scm-like with four mbt domains 1 [Source:HGNC Symbol%3BAcc:HGNC:20255]
ENSG00000171943	7.80	6.66	7.64	7.61	7.49	8.12	-0.0513084273223233	3.40595139151073	0.673610949657878	0.905696708454492	1:121184809-121392822:+	SRGAP2C	12;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0007399,biological_process nervous system development;GO:0021816,biological_process extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration;GO:0030336,biological_process negative regulation of cell migration;GO:0042803,molecular_function protein homodimerization activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0048365,molecular_function Rac GTPase binding;GO:0051490,biological_process negative regulation of filopodium assembly;GO:0061000,biological_process negative regulation of dendritic spine development;GO:2001224,biological_process positive regulation of neuron migration	NA	SLIT-ROBO Rho GTPase activating protein 2C [Source:HGNC Symbol%3BAcc:HGNC:30584]
ENSG00000152332	14.63	13.94	12.82	13.73	13.33	13.49	0.0410651704122071	4.166145688233	0.673672577874835	0.905696708454492	1:162497250-162529629:+	UHMK1	31;GO:0000166,molecular_function nucleotide binding;GO:0000243,cellular_component commitment complex;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0007050,biological_process cell cycle arrest;GO:0008187,molecular_function poly-pyrimidine tract binding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030424,cellular_component axon;GO:0030628,molecular_function pre-mRNA 3'-splice site binding;GO:0031175,biological_process neuron projection development;GO:0032839,cellular_component dendrite cytoplasm;GO:0035770,cellular_component ribonucleoprotein granule;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0045948,biological_process positive regulation of translational initiation;GO:0046777,biological_process protein autophosphorylation;GO:0046825,biological_process regulation of protein export from nucleus;GO:0071004,cellular_component U2-type prespliceosome;GO:0071598,cellular_component neuronal ribonucleoprotein granule;GO:0089701,cellular_component U2AF	NA	U2AF homology motif kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:19683]
ENSG00000254996	0.29	0.34	0.41	0.39	0.30	0.28	0.117886243555076	1.47255489508029	0.673932622977302	0.905948196774664	5:140401907-140549569:+	ANKHD1-EIF4EBP3	3;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0045087,biological_process innate immune response	NA	ANKHD1-EIF4EBP3 readthrough [Source:HGNC Symbol%3BAcc:HGNC:33530]
ENSG00000162714	10.66	10.23	11.38	10.90	11.77	10.80	-0.0363660763763078	4.36874784842223	0.674016266398552	0.905962524613452	1:247297411-247331846:-	ZNF496	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016604,cellular_component nuclear body;GO:0043621,molecular_function protein self-association;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 496 [Source:HGNC Symbol%3BAcc:HGNC:23713]
ENSG00000125834	6.92	7.10	8.45	7.76	7.76	7.99	-0.0505073611461341	3.63885989503756	0.674173348543185	0.90607554953081	20:2101610-2177038:+	STK35	12;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity	NA	serine/threonine kinase 35 [Source:HGNC Symbol%3BAcc:HGNC:16254]
ENSG00000131844	14.91	16.59	15.62	16.89	15.96	15.74	-0.0373005784638318	4.84324325614622	0.674407005100738	0.90629145331985	5:71587287-71658704:+	MCCC2	15;GO:0000166,molecular_function nucleotide binding;GO:0002169,cellular_component 3-methylcrotonyl-CoA carboxylase complex, mitochondrial;GO:0004485,molecular_function methylcrotonoyl-CoA carboxylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006552,biological_process leucine catabolic process;GO:0006768,biological_process biotin metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0015936,biological_process coenzyme A metabolic process;GO:0016874,molecular_function ligase activity;GO:0051291,biological_process protein heterooligomerization;GO:1905202,cellular_component methylcrotonoyl-CoA carboxylase complex	E6.4.1.4B; 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4]; K01969	methylcrotonoyl-CoA carboxylase 2 [Source:HGNC Symbol%3BAcc:HGNC:6937]
ENSG00000169895	63.60	65.97	62.45	63.24	66.58	67.39	-0.0284610436054077	6.10185385464624	0.674514133079481	0.906305471080257	X:16719631-16765336:+	SYAP1	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0070062,cellular_component extracellular exosome	NA	synapse associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16273]
ENSG00000165630	8.15	8.28	8.29	8.16	8.12	7.73	0.0543905468560258	3.1489892064647	0.674563461476717	0.906305471080257	10:13586926-13630868:+	PRPF18	11;GO:0000350,biological_process generation of catalytic spliceosome for second transesterification step;GO:0000386,molecular_function second spliceosomal transesterification activity;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex;GO:0071021,cellular_component U2-type post-spliceosomal complex;GO:0071048,biological_process nuclear retention of unspliced pre-mRNA at the site of transcription	PRPF18, PRP18; pre-mRNA-splicing factor 18; K12817	pre-mRNA processing factor 18 [Source:HGNC Symbol%3BAcc:HGNC:17351]
ENSG00000198585	9.25	10.22	7.95	7.85	11.53	9.58	-0.0736045428874658	3.1845059949155	0.674786544900693	0.906507075958042	3:131381670-131388830:+	NUDT16	38;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006382,biological_process adenosine to inosine editing;GO:0006402,biological_process mRNA catabolic process;GO:0006508,biological_process proteolysis;GO:0008235,molecular_function metalloexopeptidase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009117,biological_process nucleotide metabolic process;GO:0016077,biological_process snoRNA catabolic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0030515,molecular_function snoRNA binding;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0035863,biological_process dITP catabolic process;GO:0035870,molecular_function dITP diphosphatase activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046709,biological_process IDP catabolic process;GO:0046872,molecular_function metal ion binding;GO:0050072,molecular_function m7G(5')pppN diphosphatase activity;GO:0050897,molecular_function cobalt ion binding;GO:0090068,biological_process positive regulation of cell cycle process;GO:0097383,molecular_function dIDP diphosphatase activity;GO:0098519,molecular_function nucleotide phosphatase activity, acting on free nucleotides;GO:1901639,biological_process XDP catabolic process;GO:1901640,molecular_function XTP binding;GO:1901641,molecular_function ITP binding;GO:1990003,molecular_function IDP phosphatase activity;GO:2000233,biological_process negative regulation of rRNA processing;GO:2000781,biological_process positive regulation of double-strand break repair	NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]; K16855	nudix hydrolase 16 [Source:HGNC Symbol%3BAcc:HGNC:26442]
ENSG00000072110	206.44	210.53	202.13	211.80	210.65	212.05	-0.0238019695300489	9.30030045841496	0.674934048776778	0.906564913701235	14:68874142-68979440:-	ACTN1	44;GO:0001725,cellular_component stress fiber;GO:0001726,cellular_component ruffle;GO:0002576,biological_process platelet degranulation;GO:0003725,molecular_function double-stranded RNA binding;GO:0003779,molecular_function actin binding;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005911,cellular_component cell-cell junction;GO:0005916,cellular_component fascia adherens;GO:0005925,cellular_component focal adhesion;GO:0007015,biological_process actin filament organization;GO:0016020,cellular_component membrane;GO:0017166,molecular_function vinculin binding;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030220,biological_process platelet formation;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031143,cellular_component pseudopodium;GO:0036344,biological_process platelet morphogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0044325,molecular_function ion channel binding;GO:0046872,molecular_function metal ion binding;GO:0048041,biological_process focal adhesion assembly;GO:0051015,molecular_function actin filament binding;GO:0051017,biological_process actin filament bundle assembly;GO:0051271,biological_process negative regulation of cellular component movement;GO:0051639,biological_process actin filament network formation;GO:0051764,biological_process actin crosslink formation;GO:0070062,cellular_component extracellular exosome;GO:1903506,biological_process regulation of nucleic acid-templated transcription	ACTN1_4; actinin alpha 1/4; K05699	actinin alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:163]
ENSG00000180425	10.28	8.19	11.19	10.10	9.26	9.03	0.0919388951934434	2.23144448311488	0.67515039682764	0.906564913701235	11:114391442-114400511:-	C11orf71	NA	NA	chromosome 11 open reading frame 71 [Source:HGNC Symbol%3BAcc:HGNC:25937]
ENSG00000267368	3.49	4.24	4.57	4.65	3.46	5.08	-0.0981410073615964	1.81078696351105	0.675191841927651	0.906564913701235	7:102637024-102642791:-	UPK3BL1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	uroplakin 3B like 1 [Source:HGNC Symbol%3BAcc:HGNC:37278]
ENSG00000060069	6.81	6.56	6.82	6.60	6.71	6.54	0.0394211501143665	4.27829072326042	0.6753116708296	0.906564913701235	18:79679800-79756623:+	CTDP1	30;GO:0000922,cellular_component spindle pole;GO:0001096,molecular_function TFIIF-class transcription factor binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0008420,molecular_function CTD phosphatase activity;GO:0010458,biological_process exit from mitosis;GO:0015629,cellular_component actin cytoskeleton;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0030496,cellular_component midbody;GO:0030957,molecular_function Tat protein binding;GO:0043234,cellular_component protein complex;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0050434,biological_process positive regulation of viral transcription;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0061052,biological_process negative regulation of cell growth involved in cardiac muscle cell development;GO:0070940,biological_process dephosphorylation of RNA polymerase II C-terminal domain	NA	CTD phosphatase subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:2498]
ENSG00000197841	8.73	7.77	7.98	6.90	8.06	8.88	0.05219602587235	3.91111339459743	0.675355509095387	0.906564913701235	19:34734154-34745378:+	ZNF181	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 181 [Source:HGNC Symbol%3BAcc:HGNC:12971]
ENSG00000167196	16.10	14.14	15.66	16.17	15.59	15.86	-0.034508259030762	4.29964548190414	0.675380981180789	0.906564913701235	15:75903858-75942510:+	FBXO22	17;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005549,molecular_function odorant binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006913,biological_process nucleocytoplasmic transport;GO:0009267,biological_process cellular response to starvation;GO:0010830,biological_process regulation of myotube differentiation;GO:0030018,cellular_component Z disc;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0048742,biological_process regulation of skeletal muscle fiber development;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	F-box protein 22 [Source:HGNC Symbol%3BAcc:HGNC:13593]
ENSG00000169760	5.94	7.97	6.56	6.53	7.79	7.00	-0.0567906362557796	4.18020519999401	0.675383623349659	0.906564913701235	3:173396283-174286644:+	NLGN1	77;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0004872,molecular_function receptor activity;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006605,biological_process protein targeting;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007158,biological_process neuron cell-cell adhesion;GO:0007399,biological_process nervous system development;GO:0007416,biological_process synapse assembly;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010841,biological_process positive regulation of circadian sleep/wake cycle, wakefulness;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016080,biological_process synaptic vesicle targeting;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0017146,cellular_component NMDA selective glutamate receptor complex;GO:0023041,biological_process neuronal signal transduction;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030425,cellular_component dendrite;GO:0031175,biological_process neuron projection development;GO:0032230,biological_process positive regulation of synaptic transmission, GABAergic;GO:0032433,cellular_component filopodium tip;GO:0035418,biological_process protein localization to synapse;GO:0042043,molecular_function neurexin family protein binding;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0045184,biological_process establishment of protein localization;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045664,biological_process regulation of neuron differentiation;GO:0046983,molecular_function protein dimerization activity;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0048489,biological_process synaptic vesicle transport;GO:0048511,biological_process rhythmic process;GO:0048789,biological_process cytoskeletal matrix organization at active zone;GO:0050804,biological_process modulation of synaptic transmission;GO:0050808,biological_process synapse organization;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051260,biological_process protein homooligomerization;GO:0051290,biological_process protein heterotetramerization;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051965,biological_process positive regulation of synapse assembly;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0060076,cellular_component excitatory synapse;GO:0060291,biological_process long-term synaptic potentiation;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0061002,biological_process negative regulation of dendritic spine morphogenesis;GO:0072553,biological_process terminal button organization;GO:0097091,biological_process synaptic vesicle clustering;GO:0097104,biological_process postsynaptic membrane assembly;GO:0097105,biological_process presynaptic membrane assembly;GO:0097110,molecular_function scaffold protein binding;GO:0097113,biological_process AMPA glutamate receptor clustering;GO:0097114,biological_process NMDA glutamate receptor clustering;GO:0097115,biological_process neurexin clustering involved in presynaptic membrane assembly;GO:0097119,biological_process postsynaptic density protein 95 clustering;GO:0097120,biological_process receptor localization to synapse;GO:0098793,cellular_component presynapse;GO:0098942,biological_process retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0099055,cellular_component integral component of postsynaptic membrane;GO:1900029,biological_process positive regulation of ruffle assembly;GO:1900244,biological_process positive regulation of synaptic vesicle endocytosis;GO:1902474,biological_process positive regulation of protein localization to synapse;GO:1902533,biological_process positive regulation of intracellular signal transduction;GO:1904861,biological_process excitatory synapse assembly;GO:1905520,biological_process positive regulation of presynaptic active zone assembly;GO:2000302,biological_process positive regulation of synaptic vesicle exocytosis;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000809,biological_process positive regulation of synaptic vesicle clustering	NLGN; neuroligin; K07378	neuroligin 1 [Source:HGNC Symbol%3BAcc:HGNC:14291]
ENSG00000172037	62.18	50.67	62.21	59.19	50.27	62.42	0.0389084784667987	8.28715082115174	0.675499296125399	0.906564913701235	3:49121113-49133118:-	LAMB2	31;GO:0000904,biological_process cell morphogenesis involved in differentiation;GO:0005178,molecular_function integrin binding;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005605,cellular_component basal lamina;GO:0005608,cellular_component laminin-3 complex;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007155,biological_process cell adhesion;GO:0007411,biological_process axon guidance;GO:0007528,biological_process neuromuscular junction development;GO:0007601,biological_process visual perception;GO:0014002,biological_process astrocyte development;GO:0014044,biological_process Schwann cell development;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0031175,biological_process neuron projection development;GO:0043083,cellular_component synaptic cleft;GO:0043256,cellular_component laminin complex;GO:0043260,cellular_component laminin-11 complex;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045202,cellular_component synapse;GO:0048677,biological_process axon extension involved in regeneration;GO:0050808,biological_process synapse organization;GO:0060041,biological_process retina development in camera-type eye;GO:0070062,cellular_component extracellular exosome;GO:0072249,biological_process metanephric glomerular visceral epithelial cell development;GO:0072274,biological_process metanephric glomerular basement membrane development	LAMB2; laminin, beta 2; K06243	laminin subunit beta 2 [Source:HGNC Symbol%3BAcc:HGNC:6487]
ENSG00000091592	2.44	1.87	2.51	2.34	1.72	2.52	0.0710947576919485	3.35735009317165	0.675564802201893	0.906564913701235	17:5499426-5619424:-	NLRP1	29;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954,biological_process inflammatory response;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0016032,biological_process viral process;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0032495,biological_process response to muramyl dipeptide;GO:0042742,biological_process defense response to bacterium;GO:0042981,biological_process regulation of apoptotic process;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0045087,biological_process innate immune response;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050727,biological_process regulation of inflammatory response;GO:0051402,biological_process neuron apoptotic process;GO:0061702,cellular_component inflammasome complex;GO:0072558,cellular_component NLRP1 inflammasome complex;GO:0097110,molecular_function scaffold protein binding;GO:1904784,biological_process NLRP1 inflammasome complex assembly	NLRP1, CARD7; NACHT, LRR and PYD domains-containing protein 1; K12798	NLR family pyrin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14374]
ENSG00000015133	2.40	2.38	2.47	2.77	2.38	2.39	-0.0439217347462551	3.97665316029608	0.675574869738186	0.906564913701235	14:91271322-91417844:-	CCDC88C	13;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0008017,molecular_function microtubule binding;GO:0016055,biological_process Wnt signaling pathway;GO:0030165,molecular_function PDZ domain binding;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031648,biological_process protein destabilization;GO:0043621,molecular_function protein self-association;GO:0051260,biological_process protein homooligomerization;GO:0051959,molecular_function dynein light intermediate chain binding	NA	coiled-coil domain containing 88C [Source:HGNC Symbol%3BAcc:HGNC:19967]
ENSG00000170145	10.19	9.39	10.54	11.16	10.05	10.00	-0.0338741474152832	4.8382454171382	0.675707437113921	0.906564913701235	11:111602390-111730853:+	SIK2	18;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032870,biological_process cellular response to hormone stimulus;GO:0035556,biological_process intracellular signal transduction;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding	SIK2; serine/threonine-protein kinase SIK2 [EC:2.7.11.1]; K16311	salt inducible kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:21680]
ENSG00000171453	29.19	29.21	27.71	28.59	28.36	27.95	0.0311350139909504	5.0313801429408	0.675738447102391	0.906564913701235	6:43509701-43529585:+	POLR1C	19;GO:0001054,molecular_function RNA polymerase I activity;GO:0001056,molecular_function RNA polymerase III activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006360,biological_process transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0032481,biological_process positive regulation of type I interferon production;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046983,molecular_function protein dimerization activity	RPC40, POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1; K03027	RNA polymerase I subunit C [Source:HGNC Symbol%3BAcc:HGNC:20194]
ENSG00000174903	167.60	182.73	164.17	167.62	174.07	166.52	0.0275720903882949	6.68556574960584	0.675779033793404	0.906564913701235	11:66268532-66277492:+	RAB1B	26;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019068,biological_process virion assembly;GO:0030133,cellular_component transport vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0043687,biological_process post-translational protein modification;GO:0048208,biological_process COPII vesicle coating;GO:0070062,cellular_component extracellular exosome;GO:1903020,biological_process positive regulation of glycoprotein metabolic process;GO:2000785,biological_process regulation of autophagosome assembly	RAB1B; Ras-related protein Rab-1B; K07875	RAB1B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:18370]
ENSG00000186806	1.84	1.95	1.81	1.55	2.01	1.78	0.0747001285668344	2.29032894915705	0.676030363726826	0.90674210732802	19:51331535-51342124:-	VSIG10L	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	V-set and immunoglobulin domain containing 10 like [Source:HGNC Symbol%3BAcc:HGNC:27111]
ENSG00000251192	2.07	2.01	2.08	2.45	2.23	1.91	-0.0774041435932215	1.99650642150317	0.676057214478436	0.90674210732802	X:46497726-46545457:-	ZNF674	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 674 [Source:HGNC Symbol%3BAcc:HGNC:17625]
ENSG00000100359	27.85	29.36	28.59	29.53	25.86	29.30	0.0290553380343593	6.08078187538224	0.676341623868646	0.90700761965846	22:40370590-40410289:+	SGSM3	17;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005921,cellular_component gap junction;GO:0006886,biological_process intracellular protein transport;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0032483,biological_process regulation of Rab protein signal transduction;GO:0032486,biological_process Rap protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0048227,biological_process plasma membrane to endosome transport;GO:0090630,biological_process activation of GTPase activity	NA	small G protein signaling modulator 3 [Source:HGNC Symbol%3BAcc:HGNC:25228]
ENSG00000133884	48.77	46.56	50.22	51.21	47.13	45.49	0.0311706849273626	5.87795520166462	0.676401315973444	0.90700761965846	11:65333753-65353249:+	DPF2	15;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0097190,biological_process apoptotic signaling pathway	NA	double PHD fingers 2 [Source:HGNC Symbol%3BAcc:HGNC:9964]
ENSG00000213923	10.89	11.87	14.43	11.30	12.94	14.71	-0.0546477539164156	4.29356023349962	0.676503789111666	0.907047044096253	22:38290690-38318084:-	CSNK1E	38;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006364,biological_process rRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030426,cellular_component growth cone;GO:0032091,biological_process negative regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032922,biological_process circadian regulation of gene expression;GO:0042752,biological_process regulation of circadian rhythm;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0048511,biological_process rhythmic process;GO:0048512,biological_process circadian behavior;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1902004,biological_process positive regulation of beta-amyloid formation;GO:1903827,biological_process regulation of cellular protein localization;GO:1905426,biological_process positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000052,biological_process positive regulation of non-canonical Wnt signaling pathway	CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]; K08960	casein kinase 1 epsilon [Source:HGNC Symbol%3BAcc:HGNC:2453]
ENSG00000143179	31.21	28.80	28.58	32.70	28.28	30.80	-0.0375479042339387	4.56862403526523	0.67669983457214	0.907066364489344	1:165827530-165911618:+	UCK2	15;GO:0000166,molecular_function nucleotide binding;GO:0004849,molecular_function uridine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0006206,biological_process pyrimidine nucleobase metabolic process;GO:0006238,biological_process CMP salvage;GO:0008152,biological_process metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0044206,biological_process UMP salvage;GO:0044211,biological_process CTP salvage	udk, UCK; uridine kinase [EC:2.7.1.48]; K00876	uridine-cytidine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:12562]
ENSG00000170949	24.60	23.42	25.36	22.31	24.42	25.75	0.0306078631257521	6.00043036062964	0.676732748532481	0.907066364489344	19:53066605-53103436:-	ZNF160	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030097,biological_process hemopoiesis;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 160 [Source:HGNC Symbol%3BAcc:HGNC:12948]
ENSG00000130363	12.49	10.92	11.43	10.47	12.14	11.59	0.0432460227042829	4.2873307258138	0.676788207260914	0.907066364489344	6:158972870-159000187:-	RSPH3	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0042995,cellular_component cell projection	NA	radial spoke head 3 homolog [Source:HGNC Symbol%3BAcc:HGNC:21054]
ENSG00000213398	5.30	4.54	5.12	5.05	4.80	4.65	0.0666622150849981	2.86889098931998	0.67681049447356	0.907066364489344	16:67939749-67944131:-	LCAT	26;GO:0004607,molecular_function phosphatidylcholine-sterol O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030301,biological_process cholesterol transport;GO:0034186,molecular_function apolipoprotein A-I binding;GO:0034364,cellular_component high-density lipoprotein particle;GO:0034372,biological_process very-low-density lipoprotein particle remodeling;GO:0034375,biological_process high-density lipoprotein particle remodeling;GO:0034435,biological_process cholesterol esterification;GO:0042158,biological_process lipoprotein biosynthetic process;GO:0042632,biological_process cholesterol homeostasis;GO:0043691,biological_process reverse cholesterol transport;GO:0046470,biological_process phosphatidylcholine metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0090107,biological_process regulation of high-density lipoprotein particle assembly	LCAT; lecithin-cholesterol acyltransferase [EC:2.3.1.43]; K00650	lecithin-cholesterol acyltransferase [Source:HGNC Symbol%3BAcc:HGNC:6522]
ENSG00000155636	6.60	7.88	5.06	6.02	6.46	6.23	0.0608758123820672	3.22797686946613	0.677064798772424	0.907087910668763	2:178112423-178139011:+	RBM45	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0030154,biological_process cell differentiation	NA	RNA binding motif protein 45 [Source:HGNC Symbol%3BAcc:HGNC:24468]
ENSG00000184451	2.34	1.76	1.69	0.83	2.37	2.07	0.15392066690841	1.11454246136249	0.677122481158578	0.907087910668763	17:42678888-42683917:-	CCR10	16;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004950,molecular_function chemokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006935,biological_process chemotaxis;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016493,molecular_function C-C chemokine receptor activity;GO:0070098,biological_process chemokine-mediated signaling pathway	CCR10; C-C chemokine receptor type 10; K04185	C-C motif chemokine receptor 10 [Source:HGNC Symbol%3BAcc:HGNC:4474]
ENSG00000172244	7.20	8.69	7.42	8.76	8.00	7.46	-0.0524617140246082	3.93259733436584	0.677273231476691	0.907087910668763	5:43486700-43515145:-	C5orf34	NA	NA	chromosome 5 open reading frame 34 [Source:HGNC Symbol%3BAcc:HGNC:24738]
ENSG00000160803	17.12	18.02	17.51	17.90	18.30	18.02	-0.0328349288943175	5.01210866043383	0.677300086448346	0.907087910668763	1:156035300-156053794:-	UBQLN4	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031593,molecular_function polyubiquitin binding;GO:0031595,cellular_component nuclear proteasome complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:1901097,biological_process negative regulation of autophagosome maturation	UBQLN, DSK2; ubiquilin; K04523	ubiquilin 4 [Source:HGNC Symbol%3BAcc:HGNC:1237]
ENSG00000157837	26.36	25.72	28.81	28.99	29.17	25.58	-0.0343092196665396	4.99083431422093	0.677445197890569	0.907087910668763	12:120762509-120904371:-	SPPL3	27;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0032092,biological_process positive regulation of protein binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0033619,biological_process membrane protein proteolysis;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0042500,molecular_function aspartic endopeptidase activity, intramembrane cleaving;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051533,biological_process positive regulation of NFAT protein import into nucleus;GO:0070886,biological_process positive regulation of calcineurin-NFAT signaling cascade;GO:0071458,cellular_component integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane	NA	signal peptide peptidase like 3 [Source:HGNC Symbol%3BAcc:HGNC:30424]
ENSG00000171456	26.32	27.11	26.19	26.85	27.28	27.57	-0.0260930779148756	6.97685606086649	0.677498746319916	0.907087910668763	20:32358343-32439319:+	ASXL1	34;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000902,biological_process cell morphogenesis;GO:0003007,biological_process heart morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009887,biological_process organ morphogenesis;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0030097,biological_process hemopoiesis;GO:0032526,biological_process response to retinoic acid;GO:0035359,biological_process negative regulation of peroxisome proliferator activated receptor signaling pathway;GO:0035517,cellular_component PR-DUB complex;GO:0035522,biological_process monoubiquitinated histone H2A deubiquitination;GO:0042974,molecular_function retinoic acid receptor binding;GO:0042975,molecular_function peroxisome proliferator activated receptor binding;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048386,biological_process positive regulation of retinoic acid receptor signaling pathway;GO:0048387,biological_process negative regulation of retinoic acid receptor signaling pathway;GO:0048534,biological_process hematopoietic or lymphoid organ development;GO:0048538,biological_process thymus development;GO:0048539,biological_process bone marrow development;GO:0048872,biological_process homeostasis of number of cells;GO:0060348,biological_process bone development;GO:0060430,biological_process lung saccule development;GO:0070062,cellular_component extracellular exosome	NA	additional sex combs like 1%2C transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:18318]
ENSG00000175213	5.46	4.69	5.72	4.26	5.65	5.50	0.0608819675817845	3.51868703244914	0.677615173962631	0.907087910668763	11:46700817-46705912:+	ZNF408	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 408 [Source:HGNC Symbol%3BAcc:HGNC:20041]
ENSG00000196872	0.40	0.13	0.32	0.35	0.40	0.23	-0.143817716195908	0.122599763882982	0.677630022411527	0.907087910668763	2:98793845-98936259:-	KIAA1211L	NA	NA	KIAA1211 like [Source:HGNC Symbol%3BAcc:HGNC:33454]
ENSG00000156650	5.89	5.52	6.44	5.16	6.10	6.29	0.0389597223505841	5.20600630119275	0.677630680287557	0.907087910668763	10:74825581-75032622:+	KAT6B	24;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0016407,molecular_function acetyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0032403,molecular_function protein complex binding;GO:0043966,biological_process histone H3 acetylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0070776,cellular_component MOZ/MORF histone acetyltransferase complex;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	lysine acetyltransferase 6B [Source:HGNC Symbol%3BAcc:HGNC:17582]
ENSG00000119396	87.60	89.49	90.95	89.50	89.01	86.67	0.0270884223344481	5.8454270700594	0.677661966021762	0.907087910668763	9:121178136-121223014:-	RAB14	46;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009790,biological_process embryo development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019003,molecular_function GDP binding;GO:0030100,biological_process regulation of endocytosis;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0031901,cellular_component early endosome membrane;GO:0032456,biological_process endocytic recycling;GO:0032880,biological_process regulation of protein localization;GO:0042175,cellular_component nuclear outer membrane-endoplasmic reticulum membrane network;GO:0042742,biological_process defense response to bacterium;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045335,cellular_component phagocytic vesicle;GO:0046907,biological_process intracellular transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0090382,biological_process phagosome maturation	NA	RAB14%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:16524]
ENSG00000131503	0.24	0.20	0.32	0.26	0.32	0.25	-0.111426455911556	1.15599196600387	0.677793984673843	0.907087910668763	5:140401813-140539856:+	ANKHD1	5;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0045087,biological_process innate immune response	NA	ankyrin repeat and KH domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24714]
ENSG00000081041	5.28	8.34	6.19	3.97	4.73	9.20	0.128577787484486	1.10719726376236	0.677794050527538	0.907087910668763	4:74097034-74099293:-	CXCL2	17;GO:0002237,biological_process response to molecule of bacterial origin;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008009,molecular_function chemokine activity;GO:0032496,biological_process response to lipopolysaccharide;GO:0042127,biological_process regulation of cell proliferation;GO:0045236,molecular_function CXCR chemokine receptor binding;GO:0060326,biological_process cell chemotaxis;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0090023,biological_process positive regulation of neutrophil chemotaxis	CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3; K05505	C-X-C motif chemokine ligand 2 [Source:HGNC Symbol%3BAcc:HGNC:4603]
ENSG00000186638	2.39	1.96	2.30	2.28	2.40	2.31	-0.0506749077591592	3.2518053204314	0.677957342146521	0.907087910668763	9:34252380-34311371:-	KIF24	19;GO:0000166,molecular_function nucleotide binding;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0007019,biological_process microtubule depolymerization;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity;GO:0030030,biological_process cell projection organization;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking	KIF2_24, MCAK; kinesin family member 2/24; K10393	kinesin family member 24 [Source:HGNC Symbol%3BAcc:HGNC:19916]
ENSG00000104687	57.50	62.61	57.53	54.89	62.28	58.15	0.029086652607976	6.52779976412651	0.67796446473475	0.907087910668763	8:30678060-30727926:-	GSR	18;GO:0004362,molecular_function glutathione-disulfide reductase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0009897,cellular_component external side of plasma membrane;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016491,molecular_function oxidoreductase activity;GO:0016668,molecular_function oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor;GO:0034599,biological_process cellular response to oxidative stress;GO:0045454,biological_process cell redox homeostasis;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	GSR, gor; glutathione reductase (NADPH) [EC:1.8.1.7]; K00383	glutathione-disulfide reductase [Source:HGNC Symbol%3BAcc:HGNC:4623]
ENSG00000116497	25.56	21.00	21.17	24.16	23.42	22.69	-0.0360095296795373	4.82647262299483	0.678008444709329	0.907087910668763	1:32816766-32858879:+	S100PBP	4;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0016607,cellular_component nuclear speck;GO:0048306,molecular_function calcium-dependent protein binding	NA	S100P binding protein [Source:HGNC Symbol%3BAcc:HGNC:25768]
ENSG00000196843	4.16	3.32	4.01	4.37	3.36	3.35	0.0760174932787957	2.78363802240608	0.678076791788222	0.907087910668763	2:96536742-96552638:+	ARID5A	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0030331,molecular_function estrogen receptor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045087,biological_process innate immune response;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046965,molecular_function retinoid X receptor binding;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0050681,molecular_function androgen receptor binding;GO:0071391,biological_process cellular response to estrogen stimulus	NA	AT-rich interaction domain 5A [Source:HGNC Symbol%3BAcc:HGNC:17361]
ENSG00000177103	10.74	9.00	11.17	10.89	9.82	11.26	-0.0334482890551689	6.06065683223162	0.678124124530376	0.907087910668763	11:117427772-117817525:-	DSCAML1	17;GO:0001709,biological_process cell fate determination;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0042803,molecular_function protein homodimerization activity;GO:0045202,cellular_component synapse;GO:0048704,biological_process embryonic skeletal system morphogenesis	NA	DS cell adhesion molecule like 1 [Source:HGNC Symbol%3BAcc:HGNC:14656]
ENSG00000259494	17.88	14.46	14.15	16.67	15.46	16.40	-0.044326199720052	3.93334809423459	0.678141932732307	0.907087910668763	15:88459475-88467419:-	MRPL46	14;GO:0003674,molecular_function molecular_function;GO:0003735,molecular_function structural constituent of ribosome;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0030054,cellular_component cell junction;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L46 [Source:HGNC Symbol%3BAcc:HGNC:1192]
ENSG00000063322	27.08	25.57	27.77	26.50	26.18	30.78	-0.0402134171384707	4.48274303767853	0.678231788930625	0.907110354056228	19:39391302-39400637:+	MED29	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016592,cellular_component mediator complex	NA	mediator complex subunit 29 [Source:HGNC Symbol%3BAcc:HGNC:23074]
ENSG00000184785	16.73	21.49	8.28	18.94	16.45	15.25	-0.129058749499354	2.04839346344302	0.678493569836576	0.907362710879273	X:134990937-134992473:+	SMIM10	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 10 [Source:HGNC Symbol%3BAcc:HGNC:41913]
ENSG00000179431	4.31	5.61	4.49	5.77	4.22	5.20	-0.0795166248614815	2.72114595058889	0.67875169708825	0.907610127755731	11:35618418-35620868:+	FJX1	4;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007267,biological_process cell-cell signaling;GO:0010842,biological_process retina layer formation	FJX1; four-jointed box protein 1; K16674	four jointed box 1 [Source:HGNC Symbol%3BAcc:HGNC:17166]
ENSG00000168502	31.30	29.62	31.69	31.14	31.86	32.04	-0.0247371077401884	7.60625883000088	0.679052386595797	0.907859723243564	18:8705660-8832778:+	MTCL1	19;GO:0000922,cellular_component spindle pole;GO:0001578,biological_process microtubule bundle formation;GO:0003723,molecular_function RNA binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0008017,molecular_function microtubule binding;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016327,cellular_component apicolateral plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0030496,cellular_component midbody;GO:0042803,molecular_function protein homodimerization activity;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0097427,cellular_component microtubule bundle;GO:2000576,biological_process positive regulation of microtubule motor activity	NA	microtubule crosslinking factor 1 [Source:HGNC Symbol%3BAcc:HGNC:29121]
ENSG00000153179	9.59	10.40	9.31	10.24	9.45	10.79	-0.0531003969491617	3.44083861985675	0.679093873717936	0.907859723243564	12:64507000-64697567:+	RASSF3	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process	NA	Ras association domain family member 3 [Source:HGNC Symbol%3BAcc:HGNC:14271]
ENSG00000186470	36.33	38.83	37.45	33.63	42.27	34.67	0.0373166965764705	5.32350789553288	0.679157769277349	0.907859723243564	6:26365158-26378320:+	BTN3A2	7;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002456,biological_process T cell mediated immunity;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0072643,biological_process interferon-gamma secretion	NA	butyrophilin subfamily 3 member A2 [Source:HGNC Symbol%3BAcc:HGNC:1139]
ENSG00000038219	12.32	12.26	12.18	12.07	13.31	12.39	-0.0269272129561127	6.85948141955663	0.679609672828692	0.908310379575076	4:13568737-13627723:-	BOD1L1	5;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0031297,biological_process replication fork processing	NA	biorientation of chromosomes in cell division 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:31792]
ENSG00000152904	62.78	49.48	51.77	52.91	58.15	58.83	-0.0350557874472279	5.65423806213221	0.679644569323032	0.908310379575076	1:235327349-235344532:+	GGPS1	16;GO:0004161,molecular_function dimethylallyltranstransferase activity;GO:0004311,molecular_function farnesyltranstransferase activity;GO:0004337,molecular_function geranyltranstransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006720,biological_process isoprenoid metabolic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0033384,biological_process geranyl diphosphate biosynthetic process;GO:0033386,biological_process geranylgeranyl diphosphate biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0045337,biological_process farnesyl diphosphate biosynthetic process;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046872,molecular_function metal ion binding	GGPS1; geranylgeranyl diphosphate synthase, type III [EC:2.5.1.1 2.5.1.10 2.5.1.29]; K00804	geranylgeranyl diphosphate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:4249]
ENSG00000197496	1.32	1.67	1.29	1.35	1.33	1.31	0.0914050378257407	1.27562892186589	0.679714421644476	0.908310379575076	20:46709486-46736347:+	SLC2A10	22;GO:0005215,molecular_function transporter activity;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0008645,biological_process hexose transport;GO:0012505,cellular_component endomembrane system;GO:0015758,biological_process glucose transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0035428,biological_process hexose transmembrane transport;GO:0046323,biological_process glucose import;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055056,molecular_function D-glucose transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 2 member 10 [Source:HGNC Symbol%3BAcc:HGNC:13444]
ENSG00000161929	4.43	2.64	3.53	4.56	2.80	2.47	0.149947588081322	1.00945415363888	0.679947480736606	0.908354652323956	17:5208960-5234860:-	SCIMP	8;GO:0001772,cellular_component immunological synapse;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031256,cellular_component leading edge membrane;GO:0031259,cellular_component uropod membrane;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0097197,cellular_component tetraspanin-enriched microdomain	NA	SLP adaptor and CSK interacting membrane protein [Source:HGNC Symbol%3BAcc:HGNC:33504]
ENSG00000183826	2.55	2.79	2.33	2.33	2.44	2.54	0.0702856555299295	2.37406910471873	0.679951293372194	0.908354652323956	6:38168450-38640148:-	BTBD9	15;GO:0005737,cellular_component cytoplasm;GO:0007616,biological_process long-term memory;GO:0008344,biological_process adult locomotory behavior;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042428,biological_process serotonin metabolic process;GO:0042748,biological_process circadian sleep/wake cycle, non-REM sleep;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048512,biological_process circadian behavior;GO:0050804,biological_process modulation of synaptic transmission;GO:0050951,biological_process sensory perception of temperature stimulus;GO:0060586,biological_process multicellular organismal iron ion homeostasis;GO:1900242,biological_process regulation of synaptic vesicle endocytosis	NA	BTB domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:21228]
ENSG00000100504	93.76	92.25	91.50	94.00	86.01	94.80	0.0258413759955226	7.91530880741325	0.67996708526498	0.908354652323956	14:50857890-50944736:-	PYGL	32;GO:0000166,molecular_function nucleotide binding;GO:0002060,molecular_function purine nucleobase binding;GO:0003824,molecular_function catalytic activity;GO:0004645,molecular_function phosphorylase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005536,molecular_function glucose binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005980,biological_process glycogen catabolic process;GO:0006015,biological_process 5-phosphoribose 1-diphosphate biosynthetic process;GO:0008144,molecular_function drug binding;GO:0008152,biological_process metabolic process;GO:0008184,molecular_function glycogen phosphorylase activity;GO:0016208,molecular_function AMP binding;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019842,molecular_function vitamin binding;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0030246,molecular_function carbohydrate binding;GO:0032052,molecular_function bile acid binding;GO:0034774,cellular_component secretory granule lumen;GO:0042593,biological_process glucose homeostasis;GO:0042803,molecular_function protein homodimerization activity;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0070266,biological_process necroptotic process;GO:0102499,molecular_function SHG alpha-glucan phosphorylase activity;GO:1904813,cellular_component ficolin-1-rich granule lumen	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]; K00688	glycogen phosphorylase L [Source:HGNC Symbol%3BAcc:HGNC:9725]
ENSG00000140943	54.91	56.93	52.57	55.22	59.60	54.08	-0.0276465632711633	7.54255658746765	0.680159228927475	0.908513559526175	16:84053760-84116906:-	MBTPS1	28;GO:0000139,cellular_component Golgi membrane;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0007040,biological_process lysosome organization;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0042990,biological_process regulation of transcription factor import into nucleus;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0051004,biological_process regulation of lipoprotein lipase activity	MBTPS1; membrane-bound transcription factor site-1 protease [EC:3.4.21.112]; K08653	membrane bound transcription factor peptidase%2C site 1 [Source:HGNC Symbol%3BAcc:HGNC:15456]
ENSG00000143183	76.30	80.09	74.73	78.59	76.92	72.89	0.0272258001918986	6.02109255431466	0.680323510720653	0.908635220419138	1:165724292-165827755:-	TMCO1	14;GO:0000139,cellular_component Golgi membrane;GO:0005262,molecular_function calcium channel activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006983,biological_process ER overload response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0070588,biological_process calcium ion transmembrane transport	NA	transmembrane and coiled-coil domains 1 [Source:HGNC Symbol%3BAcc:HGNC:18188]
ENSG00000160392	3.99	4.74	4.11	4.90	4.18	3.15	0.0768300781890828	2.62738196476871	0.68044814670273	0.908703910169015	19:40319535-40348527:-	C19orf47	2;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm	NA	chromosome 19 open reading frame 47 [Source:HGNC Symbol%3BAcc:HGNC:26723]
ENSG00000137193	31.74	26.77	29.39	31.81	28.43	30.85	-0.0340019783914085	4.81996923230584	0.680657771989823	0.908886071827632	6:37170202-37175426:+	PIM1	32;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008134,molecular_function transcription factor binding;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030145,molecular_function manganese ion binding;GO:0030212,biological_process hyaluronan metabolic process;GO:0043024,molecular_function ribosomal small subunit binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0070561,biological_process vitamin D receptor signaling pathway;GO:1905062,biological_process positive regulation of cardioblast proliferation	NA	Pim-1 proto-oncogene%2C serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:8986]
ENSG00000156502	13.54	13.62	15.39	14.10	13.86	13.99	0.0341625505157204	5.06144815011043	0.680852147736473	0.909042861603025	10:69180231-69209099:+	SUPV3L1	31;GO:0000166,molecular_function nucleotide binding;GO:0000958,biological_process mitochondrial mRNA catabolic process;GO:0000962,biological_process positive regulation of mitochondrial RNA catabolic process;GO:0000965,biological_process mitochondrial RNA 3'-end processing;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006310,biological_process DNA recombination;GO:0006401,biological_process RNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0030307,biological_process positive regulation of cell growth;GO:0032508,biological_process DNA duplex unwinding;GO:0034458,molecular_function 3'-5' RNA helicase activity;GO:0035945,biological_process mitochondrial ncRNA surveillance;GO:0035946,biological_process mitochondrial mRNA surveillance;GO:0042645,cellular_component mitochondrial nucleoid;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045025,cellular_component mitochondrial degradosome;GO:0070584,biological_process mitochondrion morphogenesis;GO:0070827,biological_process chromatin maintenance;GO:2000827,biological_process mitochondrial RNA surveillance	NA	Suv3 like RNA helicase [Source:HGNC Symbol%3BAcc:HGNC:11471]
ENSG00000134070	5.99	6.01	6.99	7.35	5.70	6.86	-0.0548778260608931	3.62533168808133	0.680956310370288	0.909042861603025	3:10164864-10243743:+	IRAK2	31;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001959,biological_process regulation of cytokine-mediated signaling pathway;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0010008,cellular_component endosome membrane;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0042803,molecular_function protein homodimerization activity;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0070555,biological_process response to interleukin-1	IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]; K04731	interleukin 1 receptor associated kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6113]
ENSG00000100568	108.60	107.36	106.58	112.31	102.04	104.75	0.0272514460129782	6.36710240687034	0.681053600679965	0.909042861603025	14:67647074-67674831:-	VTI1B	41;GO:0000149,molecular_function SNARE binding;GO:0002576,biological_process platelet degranulation;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006623,biological_process protein targeting to vacuole;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0006896,biological_process Golgi to vacuole transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0008283,biological_process cell proliferation;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019869,molecular_function chloride channel inhibitor activity;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031201,cellular_component SNARE complex;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048280,biological_process vesicle fusion with Golgi apparatus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061025,biological_process membrane fusion;GO:0065009,biological_process regulation of molecular function;GO:1903076,biological_process regulation of protein localization to plasma membrane	VTI1; vesicle transport through interaction with t-SNAREs 1; K08493	vesicle transport through interaction with t-SNAREs 1B [Source:HGNC Symbol%3BAcc:HGNC:17793]
ENSG00000167394	3.85	4.17	3.10	3.23	4.76	3.80	-0.0797861934538641	2.90315103939338	0.681068123169913	0.909042861603025	16:31060842-31074320:-	ZNF668	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 668 [Source:HGNC Symbol%3BAcc:HGNC:25821]
ENSG00000118263	10.90	7.91	11.21	10.49	7.06	11.22	0.0817640257350778	3.29504614193883	0.681290063109973	0.909241323877442	2:207074136-207167267:-	KLF7	18;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0008270,molecular_function zinc ion binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048813,biological_process dendrite morphogenesis	NA	Kruppel like factor 7 [Source:HGNC Symbol%3BAcc:HGNC:6350]
ENSG00000198742	27.03	28.57	29.49	31.06	25.01	27.71	0.0334493633119561	6.00220566389515	0.681452295655433	0.909324289564333	7:99027437-99144100:-	SMURF1	41;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006611,biological_process protein export from nucleus;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007398,biological_process ectoderm development;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0030279,biological_process negative regulation of ossification;GO:0030424,cellular_component axon;GO:0030509,biological_process BMP signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030579,biological_process ubiquitin-dependent SMAD protein catabolic process;GO:0032801,biological_process receptor catabolic process;GO:0034394,biological_process protein localization to cell surface;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043025,cellular_component neuronal cell body;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048185,molecular_function activin binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061734,biological_process parkin-mediated mitophagy in response to mitochondrial depolarization;GO:0061736,biological_process engulfment of target by autophagosome;GO:0061753,biological_process substrate localization to autophagosome;GO:0070062,cellular_component extracellular exosome;GO:0070411,molecular_function I-SMAD binding;GO:0070412,molecular_function R-SMAD binding;GO:0071211,biological_process protein targeting to vacuole involved in autophagy;GO:0072661,biological_process protein targeting to plasma membrane;GO:1903861,biological_process positive regulation of dendrite extension;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	SMURF; E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]; K04678	SMAD specific E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:16807]
ENSG00000100246	55.19	52.74	60.73	59.12	50.15	56.29	0.0418834480928779	4.36310698593222	0.681498740499234	0.909324289564333	22:38778507-38794198:-	DNAL4	17;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007017,biological_process microtubule-based process;GO:0007018,biological_process microtubule-based movement;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0030286,cellular_component dynein complex;GO:0042995,cellular_component cell projection;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:2000582,biological_process positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	DNAL4; dynein light chain 4, axonemal; K10412	dynein axonemal light chain 4 [Source:HGNC Symbol%3BAcc:HGNC:2955]
ENSG00000168090	113.39	118.36	115.69	118.53	115.04	110.24	0.0263022369234385	6.82292768291103	0.68161476042935	0.909381343638169	7:100088953-100092200:+	COPS6	12;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0008180,cellular_component COP9 signalosome;GO:0016032,biological_process viral process;GO:0043687,biological_process post-translational protein modification;GO:0070062,cellular_component extracellular exosome	NA	COP9 signalosome subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:21749]
ENSG00000141367	146.21	159.55	141.93	138.82	156.07	147.69	0.0282113215953822	9.56877207937142	0.681765802522201	0.909468978327812	17:59619688-59696956:+	CLTC	61;GO:0000278,biological_process mitotic cell cycle;GO:0001649,biological_process osteoblast differentiation;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0005925,cellular_component focal adhesion;GO:0006886,biological_process intracellular protein transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006914,biological_process autophagy;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019901,molecular_function protein kinase binding;GO:0030117,cellular_component membrane coat;GO:0030118,cellular_component clathrin coat;GO:0030130,cellular_component clathrin coat of trans-Golgi network vesicle;GO:0030132,cellular_component clathrin coat of coated pit;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031012,cellular_component extracellular matrix;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031623,biological_process receptor internalization;GO:0032051,molecular_function clathrin light chain binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0033572,biological_process transferrin transport;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0036020,cellular_component endolysosome membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042470,cellular_component melanosome;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0045056,biological_process transcytosis;GO:0048268,biological_process clathrin coat assembly;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0051301,biological_process cell division;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0071439,cellular_component clathrin complex;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0097718,molecular_function disordered domain specific binding;GO:1900126,biological_process negative regulation of hyaluronan biosynthetic process;GO:1903077,biological_process negative regulation of protein localization to plasma membrane;GO:1903561,cellular_component extracellular vesicle;GO:1990498,cellular_component mitotic spindle microtubule	CLTC; clathrin heavy chain; K04646	clathrin heavy chain [Source:HGNC Symbol%3BAcc:HGNC:2092]
ENSG00000188761	7.41	9.09	6.43	10.76	5.30	8.74	-0.114223398006337	2.08173843237044	0.681896956667378	0.909468978327812	1:113878167-113887547:-	BCL2L15	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0042981,biological_process regulation of apoptotic process	NA	BCL2 like 15 [Source:HGNC Symbol%3BAcc:HGNC:33624]
ENSG00000115392	26.61	29.20	26.18	27.36	27.90	29.10	-0.0349830844871769	5.10569108709485	0.681907433379472	0.909468978327812	2:58159242-58241372:-	FANCL	20;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007276,biological_process gamete generation;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0036297,biological_process interstrand cross-link repair;GO:0042127,biological_process regulation of cell proliferation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]; K10606	Fanconi anemia complementation group L [Source:HGNC Symbol%3BAcc:HGNC:20748]
ENSG00000111775	96.11	110.18	88.23	111.05	98.80	94.83	-0.0426867786805442	5.03348130772075	0.681973515691233	0.909468978327812	12:120438089-120440742:+	COX6A1	12;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030234,molecular_function enzyme regulator activity;GO:0050790,biological_process regulation of catalytic activity;GO:1902600,biological_process hydrogen ion transmembrane transport	COX6A; cytochrome c oxidase subunit 6a; K02266	cytochrome c oxidase subunit 6A1 [Source:HGNC Symbol%3BAcc:HGNC:2277]
ENSG00000117533	24.88	21.01	21.58	21.42	23.13	26.27	-0.0535698381123234	3.31354186485927	0.682273894677802	0.90971209517797	1:171700159-171742247:-	VAMP4	23;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035493,biological_process SNARE complex assembly;GO:0061024,biological_process membrane organization;GO:0090161,biological_process Golgi ribbon formation	VAMP4; vesicle-associated membrane protein 4; K08513	vesicle associated membrane protein 4 [Source:HGNC Symbol%3BAcc:HGNC:12645]
ENSG00000105321	24.56	21.90	26.06	25.57	21.19	24.59	0.0390330875476771	5.26435591631184	0.68230239314484	0.90971209517797	19:47255979-47271953:+	CCDC9	2;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:24560]
ENSG00000283486	4.67	8.90	7.51	7.31	6.15	6.23	0.0909857382695209	2.20815702613786	0.682580857589072	0.909853460465103	9:38540568-38577207:-	FAM95C	NA	NA	family with sequence similarity 95 member C [Source:HGNC Symbol%3BAcc:HGNC:45272]
ENSG00000102580	9.86	8.15	8.62	8.81	8.58	8.70	0.0491905223577774	3.75225923215928	0.682682789552817	0.909853460465103	13:95677138-95794989:+	DNAJC3	28;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0031205,cellular_component endoplasmic reticulum Sec complex;GO:0035578,cellular_component azurophil granule lumen;GO:0036494,biological_process positive regulation of translation initiation in response to endoplasmic reticulum stress;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0051087,molecular_function chaperone binding;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0051607,biological_process defense response to virus;GO:0051787,molecular_function misfolded protein binding;GO:0070062,cellular_component extracellular exosome;GO:0070417,biological_process cellular response to cold;GO:1903561,cellular_component extracellular vesicle;GO:1903912,biological_process negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	DNAJC3; DnaJ homolog subfamily C member 3; K09523	DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol%3BAcc:HGNC:9439]
ENSG00000101412	8.83	7.36	6.57	7.42	6.71	7.94	0.0584993164750829	3.31811510753112	0.68279694257619	0.909853460465103	20:33675682-33686404:-	E2F1	49;GO:0000077,biological_process DNA damage checkpoint;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001047,molecular_function core promoter binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0007283,biological_process spermatogenesis;GO:0008134,molecular_function transcription factor binding;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010628,biological_process positive regulation of gene expression;GO:0019901,molecular_function protein kinase binding;GO:0030900,biological_process forebrain development;GO:0035189,cellular_component Rb-E2F complex;GO:0043276,biological_process anoikis;GO:0043392,biological_process negative regulation of DNA binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048255,biological_process mRNA stabilization;GO:0051726,biological_process regulation of cell cycle;GO:0070345,biological_process negative regulation of fat cell proliferation;GO:0071398,biological_process cellular response to fatty acid;GO:0071456,biological_process cellular response to hypoxia;GO:0071466,biological_process cellular response to xenobiotic stimulus;GO:0071930,biological_process negative regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1990086,biological_process lens fiber cell apoptotic process;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	E2F1; transcription factor E2F1; K17454	E2F transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:3113]
ENSG00000115808	11.44	11.72	10.38	10.65	11.70	12.29	-0.0390025791802754	4.7413138739828	0.682955120925676	0.909853460465103	2:36843639-36966472:-	STRN	20;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005923,cellular_component bicellular tight junction;GO:0007626,biological_process locomotory behavior;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016358,biological_process dendrite development;GO:0030331,molecular_function estrogen receptor binding;GO:0032403,molecular_function protein complex binding;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0045211,cellular_component postsynaptic membrane;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070016,molecular_function armadillo repeat domain binding;GO:0070830,biological_process bicellular tight junction assembly	NA	striatin [Source:HGNC Symbol%3BAcc:HGNC:11424]
ENSG00000163795	1.09	1.59	1.86	1.34	1.68	1.95	-0.130988044993666	1.44546524952886	0.683001142962283	0.909853460465103	2:27377230-27380790:-	ZNF513	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007601,biological_process visual perception;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0046872,molecular_function metal ion binding;GO:0050896,biological_process response to stimulus;GO:0060041,biological_process retina development in camera-type eye	NA	zinc finger protein 513 [Source:HGNC Symbol%3BAcc:HGNC:26498]
ENSG00000134222	25.89	28.30	24.42	25.71	29.02	26.41	-0.0385065338303969	4.90555296278679	0.683018710053199	0.909853460465103	1:109279555-109283186:-	PSRC1	21;GO:0000922,cellular_component spindle pole;GO:0001578,biological_process microtubule bundle formation;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008017,molecular_function microtubule binding;GO:0009987,biological_process cellular process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030308,biological_process negative regulation of cell growth;GO:0030496,cellular_component midbody;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization	NA	proline and serine rich coiled-coil 1 [Source:HGNC Symbol%3BAcc:HGNC:24472]
ENSG00000151651	0.90	0.72	0.63	0.79	0.65	1.03	-0.119401072314832	1.1801304193005	0.68304950886338	0.909853460465103	10:133262402-133276868:-	ADAM8	57;GO:0000902,biological_process cell morphogenesis;GO:0001525,biological_process angiogenesis;GO:0002102,cellular_component podosome;GO:0002523,biological_process leukocyte migration involved in inflammatory response;GO:0002675,biological_process positive regulation of acute inflammatory response;GO:0002693,biological_process positive regulation of cellular extravasation;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0006954,biological_process inflammatory response;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009986,cellular_component cell surface;GO:0010954,biological_process positive regulation of protein processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016787,molecular_function hydrolase activity;GO:0022407,biological_process regulation of cell-cell adhesion;GO:0022617,biological_process extracellular matrix disassembly;GO:0032010,cellular_component phagolysosome;GO:0032127,cellular_component dense core granule membrane;GO:0033089,biological_process positive regulation of T cell differentiation in thymus;GO:0035419,biological_process activation of MAPK activity involved in innate immune response;GO:0035579,cellular_component specific granule membrane;GO:0042581,cellular_component specific granule;GO:0043312,biological_process neutrophil degranulation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043621,molecular_function protein self-association;GO:0045780,biological_process positive regulation of bone resorption;GO:0045785,biological_process positive regulation of cell adhesion;GO:0046872,molecular_function metal ion binding;GO:0048247,biological_process lymphocyte chemotaxis;GO:0050714,biological_process positive regulation of protein secretion;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070245,biological_process positive regulation of thymocyte apoptotic process;GO:0070820,cellular_component tertiary granule;GO:0070821,cellular_component tertiary granule membrane;GO:0071065,cellular_component alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;GO:0071133,cellular_component alpha9-beta1 integrin-ADAM8 complex;GO:0071456,biological_process cellular response to hypoxia;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:2000309,biological_process positive regulation of tumor necrosis factor (ligand) superfamily member 11 production;GO:2000391,biological_process positive regulation of neutrophil extravasation;GO:2000406,biological_process positive regulation of T cell migration;GO:2000415,biological_process positive regulation of fibronectin-dependent thymocyte migration;GO:2000418,biological_process positive regulation of eosinophil migration	NA	ADAM metallopeptidase domain 8 [Source:HGNC Symbol%3BAcc:HGNC:215]
ENSG00000178028	19.34	21.19	20.15	19.64	22.92	20.11	-0.0373729967149265	4.93285709098035	0.683050153156948	0.909853460465103	1:44213454-44220681:+	DMAP1	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006306,biological_process DNA methylation;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0045471,biological_process response to ethanol;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	DNA methyltransferase 1 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18291]
ENSG00000127334	10.91	7.90	9.70	10.22	8.51	9.16	0.0539824368566261	4.20398769918383	0.683096480898915	0.909853460465103	12:67648337-67665406:+	DYRK2	29;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030145,molecular_function manganese ion binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045725,biological_process positive regulation of glycogen biosynthetic process;GO:0051534,biological_process negative regulation of NFAT protein import into nucleus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:3093]
ENSG00000173163	22.77	26.89	20.01	21.48	22.59	23.63	0.0424395852489708	4.07467007697892	0.683282028756232	0.909853460465103	2:61888723-62147247:+	COMMD1	37;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0048227,biological_process plasma membrane to endosome transport;GO:0055037,cellular_component recycling endosome;GO:0055070,biological_process copper ion homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0070300,molecular_function phosphatidic acid binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:1902306,biological_process negative regulation of sodium ion transmembrane transport;GO:2000009,biological_process negative regulation of protein localization to cell surface	NA	copper metabolism domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23024]
ENSG00000104731	9.57	8.81	8.22	9.58	8.74	9.20	-0.0365102587445712	4.65197915230835	0.68329140149758	0.909853460465103	16:87696484-87765992:-	KLHDC4	1;GO:0005515,molecular_function protein binding	NA	kelch domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25272]
ENSG00000120334	9.30	9.96	11.20	10.30	9.53	9.86	0.0488448318947924	3.57101643224441	0.683380947269364	0.909853460465103	1:173799549-173824720:-	CENPL	8;GO:0000775,cellular_component chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0034080,biological_process CENP-A containing nucleosome assembly	NA	centromere protein L [Source:HGNC Symbol%3BAcc:HGNC:17879]
ENSG00000163510	13.92	12.56	13.64	12.89	13.92	14.61	-0.0307186592138006	5.21925829738388	0.683431586067793	0.909853460465103	2:179944875-180007113:-	CWC22	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0071006,cellular_component U2-type catalytic step 1 spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	CWC22 spliceosome associated protein homolog [Source:HGNC Symbol%3BAcc:HGNC:29322]
ENSG00000162924	3.00	1.96	2.97	2.86	2.78	1.93	0.100353806550893	2.31790094873268	0.683457389280938	0.909853460465103	2:60881520-60931610:+	REL	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0010629,biological_process negative regulation of gene expression;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0033256,cellular_component I-kappaB/NF-kappaB complex;GO:0034097,biological_process response to cytokine;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045087,biological_process innate immune response;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1901215,biological_process negative regulation of neuron death	REL; c-Rel proto-oncogene protein; K09254	REL proto-oncogene%2C NF-kB subunit [Source:HGNC Symbol%3BAcc:HGNC:9954]
ENSG00000165996	22.41	25.89	25.96	25.66	22.27	24.87	0.0361407735334391	4.75989795472134	0.683580956485094	0.909853460465103	10:17589031-17617377:-	HACD1	19;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0018812,molecular_function 3-hydroxyacyl-CoA dehydratase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030497,biological_process fatty acid elongation;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0080023,molecular_function 3R-hydroxyacyl-CoA dehydratase activity;GO:0102343,molecular_function 3-hydroxy-arachidoyl-CoA dehydratase activity;GO:0102344,molecular_function 3-hydroxy-behenoyl-CoA dehydratase activity;GO:0102345,molecular_function 3-hydroxy-lignoceroyl-CoA dehydratase activity	HACD, PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]; K10703	3-hydroxyacyl-CoA dehydratase 1 [Source:HGNC Symbol%3BAcc:HGNC:9639]
ENSG00000125703	14.40	14.30	14.00	14.73	14.26	15.15	-0.0370541424925985	4.33527855005955	0.68358119490031	0.909853460465103	1:62784134-62865513:+	ATG4C	17;GO:0000045,biological_process autophagosome assembly;GO:0000422,biological_process mitophagy;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006501,biological_process C-terminal protein lipidation;GO:0006508,biological_process proteolysis;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0015031,biological_process protein transport;GO:0016787,molecular_function hydrolase activity;GO:0044804,biological_process nucleophagy;GO:0051697,biological_process protein delipidation	ATG4; cysteine protease ATG4 [EC:3.4.22.-]; K08342	autophagy related 4C cysteine peptidase [Source:HGNC Symbol%3BAcc:HGNC:16040]
ENSG00000112312	50.80	55.48	48.13	52.66	52.13	54.17	-0.0360130234433435	5.03907076639509	0.683660153332009	0.909860993171462	6:24774930-24786099:+	GMNN	19;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006275,biological_process regulation of DNA replication;GO:0006461,biological_process protein complex assembly;GO:0007049,biological_process cell cycle;GO:0008156,biological_process negative regulation of DNA replication;GO:0009887,biological_process organ morphogenesis;GO:0035563,biological_process positive regulation of chromatin binding;GO:0042826,molecular_function histone deacetylase binding;GO:0045786,biological_process negative regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070491,molecular_function repressing transcription factor binding;GO:0071163,biological_process DNA replication preinitiation complex assembly;GO:2000104,biological_process negative regulation of DNA-dependent DNA replication	NA	geminin%2C DNA replication inhibitor [Source:HGNC Symbol%3BAcc:HGNC:17493]
ENSG00000143367	19.93	16.76	17.59	20.24	18.25	17.94	-0.0377285636548129	4.45831934814362	0.683794916901523	0.909942785538015	1:151540304-151583583:+	TUFT1	7;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0030282,biological_process bone mineralization;GO:0030345,molecular_function structural constituent of tooth enamel;GO:0031214,biological_process biomineral tissue development;GO:0042476,biological_process odontogenesis	NA	tuftelin 1 [Source:HGNC Symbol%3BAcc:HGNC:12422]
ENSG00000115207	21.82	21.11	19.97	20.92	23.00	20.78	-0.0286070280553949	5.98734751402237	0.684075908494761	0.910162044130333	2:27325848-27357034:-	GTF3C2	8;GO:0000127,cellular_component transcription factor TFIIIC complex;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0042791,biological_process 5S class rRNA transcription from RNA polymerase III type 1 promoter;GO:0042797,biological_process tRNA transcription from RNA polymerase III promoter	NA	general transcription factor IIIC subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:4665]
ENSG00000132003	6.21	6.32	5.60	5.69	5.95	6.12	0.0372186049164384	4.33126923281073	0.684106329794248	0.910162044130333	19:13795459-13832230:+	ZSWIM4	2;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger SWIM-type containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25704]
ENSG00000138658	1.99	1.86	1.78	1.90	2.10	1.87	-0.0467134387769807	3.64980040340748	0.684376845284563	0.910334173362486	4:112539332-112636995:-	ZGRF1	3;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	zinc finger GRF-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25654]
ENSG00000205744	7.41	6.12	7.69	7.20	7.80	7.14	-0.0384878635928157	4.13626270917329	0.684382381843126	0.910334173362486	19:6467206-6482557:-	DENND1C	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	DENN domain containing 1C [Source:HGNC Symbol%3BAcc:HGNC:26225]
ENSG00000168438	14.66	14.61	15.03	14.33	15.70	15.70	-0.0336173328617938	4.75863653192257	0.684621933325108	0.910437184443307	6:110180140-110254275:+	CDC40	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0031124,biological_process mRNA 3'-end processing;GO:0071013,cellular_component catalytic step 2 spliceosome	CDC40, PRP17; pre-mRNA-processing factor 17; K12816	cell division cycle 40 [Source:HGNC Symbol%3BAcc:HGNC:17350]
ENSG00000030066	15.68	16.66	15.07	16.17	16.55	15.95	-0.028412313564921	6.16082127608857	0.684649215536976	0.910437184443307	11:47778086-47848555:-	NUP160	23;GO:0000776,cellular_component kinetochore;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031080,cellular_component nuclear pore outer ring;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP160, NUP120; nuclear pore complex protein Nup160; K14303	nucleoporin 160 [Source:HGNC Symbol%3BAcc:HGNC:18017]
ENSG00000183648	53.14	47.33	59.82	60.37	56.34	50.67	-0.0424070803045328	4.12169838149399	0.684737181955847	0.910437184443307	14:92116121-92121917:-	NDUFB1	13;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain	NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1; K03957	NADH:ubiquinone oxidoreductase subunit B1 [Source:HGNC Symbol%3BAcc:HGNC:7695]
ENSG00000171097	8.13	7.96	7.41	7.84	8.16	6.96	0.0465224471439206	3.75770606262269	0.684753206635198	0.910437184443307	9:128832941-128882494:-	KYAT1	24;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0006569,biological_process tryptophan catabolic process;GO:0006575,biological_process cellular modified amino acid metabolic process;GO:0008483,molecular_function transaminase activity;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009058,biological_process biosynthetic process;GO:0016212,molecular_function kynurenine-oxoglutarate transaminase activity;GO:0016740,molecular_function transferase activity;GO:0016829,molecular_function lyase activity;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042803,molecular_function protein homodimerization activity;GO:0047312,molecular_function L-phenylalanine:pyruvate aminotransferase activity;GO:0047316,molecular_function glutamine-phenylpyruvate transaminase activity;GO:0047804,molecular_function cysteine-S-conjugate beta-lyase activity;GO:0047945,molecular_function L-glutamine:pyruvate aminotransferase activity;GO:0070189,biological_process kynurenine metabolic process;GO:0070548,molecular_function L-glutamine aminotransferase activity;GO:0097052,biological_process L-kynurenine metabolic process;GO:0097053,biological_process L-kynurenine catabolic process	CCBL; kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.7 4.4.1.13 2.6.1.64]; K00816	kynurenine aminotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:1564]
ENSG00000101236	19.50	14.14	22.50	17.43	17.35	19.56	0.0724507889926442	3.25774829621715	0.684882486721647	0.910511546286367	20:3927308-4015582:-	RNF24	11;GO:0000139,cellular_component Golgi membrane;GO:0000209,biological_process protein polyubiquitination;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 24 [Source:HGNC Symbol%3BAcc:HGNC:13779]
ENSG00000111696	3.09	1.90	2.19	3.41	2.35	2.09	-0.0999880072205326	2.16324204526666	0.685049513862042	0.910636069347776	12:103770452-103841197:-	NT5DC3	5;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0043235,cellular_component receptor complex;GO:0046872,molecular_function metal ion binding	NA	5'-nucleotidase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:30826]
ENSG00000204209	30.95	31.30	30.37	31.30	32.49	31.26	-0.0261841731911407	6.12150097427634	0.685126659899814	0.910641099618416	6:33318557-33329286:-	DAXX	46;GO:0000775,cellular_component chromosome, centromeric region;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002039,molecular_function p53 binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006334,biological_process nucleosome assembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0007257,biological_process activation of JUN kinase activity;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030295,molecular_function protein kinase activator activity;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031072,molecular_function heat shock protein binding;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032183,molecular_function SUMO binding;GO:0034605,biological_process cellular response to heat;GO:0034620,biological_process cellular response to unfolded protein;GO:0042393,molecular_function histone binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0050681,molecular_function androgen receptor binding;GO:0070603,cellular_component SWI/SNF superfamily-type complex;GO:0071276,biological_process cellular response to cadmium ion;GO:0071280,biological_process cellular response to copper ion;GO:0072738,biological_process cellular response to diamide;GO:1901216,biological_process positive regulation of neuron death;GO:1903936,biological_process cellular response to sodium arsenite	DAXX; death-associated protein 6; K02308	death domain associated protein [Source:HGNC Symbol%3BAcc:HGNC:2681]
ENSG00000130724	104.56	100.49	104.71	104.63	108.09	105.34	-0.0251628017598332	6.38227695685712	0.685437452334896	0.910956648376131	19:58551565-58555124:-	CHMP2A	39;GO:0000785,cellular_component chromatin;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005635,cellular_component nuclear envelope;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007080,biological_process mitotic metaphase plate congression;GO:0010324,biological_process membrane invagination;GO:0010458,biological_process exit from mitosis;GO:0010824,biological_process regulation of centrosome duplication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0019904,molecular_function protein domain specific binding;GO:0030117,cellular_component membrane coat;GO:0031210,molecular_function phosphatidylcholine binding;GO:0031468,biological_process nuclear envelope reassembly;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0045184,biological_process establishment of protein localization;GO:0050792,biological_process regulation of viral process;GO:0051258,biological_process protein polymerization;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1902188,biological_process positive regulation of viral release from host cell;GO:1903543,biological_process positive regulation of exosomal secretion;GO:1903723,biological_process negative regulation of centriole elongation;GO:1904903,biological_process ESCRT III complex disassembly	NA	charged multivesicular body protein 2A [Source:HGNC Symbol%3BAcc:HGNC:30216]
ENSG00000140157	49.50	49.73	47.77	48.67	47.05	49.68	0.0263425198833742	5.72262408982139	0.685797450592002	0.911221664909005	15:22838640-22868384:+	NIPA2	10;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1903830,biological_process magnesium ion transmembrane transport	NA	non imprinted in Prader-Willi/Angelman syndrome 2 [Source:HGNC Symbol%3BAcc:HGNC:17044]
ENSG00000075407	4.75	3.94	4.12	5.38	3.99	4.21	-0.0640251387288088	2.99299163661574	0.685850156617103	0.911221664909005	10:38094333-38150293:+	ZNF37A	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 37A [Source:HGNC Symbol%3BAcc:HGNC:13102]
ENSG00000184988	3.14	3.40	2.81	3.05	3.18	2.50	0.105107957068461	1.32738230751031	0.685857086541918	0.911221664909005	17:43211834-43220041:+	TMEM106A	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	transmembrane protein 106A [Source:HGNC Symbol%3BAcc:HGNC:28288]
ENSG00000106031	4.73	2.55	3.92	3.67	3.06	3.93	0.105088876078749	2.15374307591536	0.686174003197369	0.911383014624408	7:27193502-27200106:-	HOXA13	9;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045111,cellular_component intermediate filament cytoskeleton	NA	homeobox A13 [Source:HGNC Symbol%3BAcc:HGNC:5102]
ENSG00000145868	15.60	15.47	16.27	15.42	15.47	15.98	0.0267638585433472	5.81149239638948	0.686291792654778	0.911383014624408	5:148383934-148442836:+	FBXO38	3;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0010976,biological_process positive regulation of neuron projection development	NA	F-box protein 38 [Source:HGNC Symbol%3BAcc:HGNC:28844]
ENSG00000196867	4.52	4.88	5.11	4.80	5.05	4.33	0.0467505393382757	3.74711291423997	0.686357067246359	0.911383014624408	19:56538947-56556810:+	ZFP28	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP28 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:17801]
ENSG00000119574	7.56	8.29	8.02	7.08	8.91	7.20	0.0510342091773889	3.60292275457633	0.686456132634793	0.911383014624408	19:58513529-58538911:-	ZBTB45	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007399,biological_process nervous system development;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 45 [Source:HGNC Symbol%3BAcc:HGNC:23715]
ENSG00000178149	41.26	37.81	38.65	39.62	40.75	40.59	-0.025513560382216	6.10877293512085	0.686531806409566	0.911383014624408	3:49015487-49022293:-	DALRD3	7;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004814,molecular_function arginine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006420,biological_process arginyl-tRNA aminoacylation	NA	DALR anticodon binding domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25536]
ENSG00000113070	0.68	2.30	1.53	1.80	1.46	0.56	0.207844398785298	-0.0157286270677716	0.686564318864588	0.911383014624408	5:140332842-140346631:-	HBEGF	41;GO:0000165,biological_process MAPK cascade;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007517,biological_process muscle organ development;GO:0008016,biological_process regulation of heart contraction;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0035313,biological_process wound healing, spreading of epidermal cells;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051545,biological_process negative regulation of elastin biosynthetic process;GO:0051549,biological_process positive regulation of keratinocyte migration;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060326,biological_process cell chemotaxis;GO:0090303,biological_process positive regulation of wound healing;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:2000145,biological_process regulation of cell motility	HBEGF; heparin-binding EGF-like growth factor; K08523	heparin binding EGF like growth factor [Source:HGNC Symbol%3BAcc:HGNC:3059]
ENSG00000166436	4.04	4.03	4.85	4.92	4.11	4.45	-0.0457729150470023	4.05905821991677	0.686676043807996	0.911383014624408	11:8612036-8671866:-	TRIM66	6;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008270,molecular_function zinc ion binding;GO:0016235,cellular_component aggresome;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 66 [Source:HGNC Symbol%3BAcc:HGNC:29005]
ENSG00000188042	548.87	472.61	553.84	539.85	502.64	580.47	-0.0304944954589337	8.33275568981594	0.686676240007112	0.911383014624408	2:234493040-234497053:-	ARL4C	16;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0030175,cellular_component filopodium;GO:0032456,biological_process endocytic recycling;GO:0042995,cellular_component cell projection;GO:0043014,molecular_function alpha-tubulin binding	NA	ADP ribosylation factor like GTPase 4C [Source:HGNC Symbol%3BAcc:HGNC:698]
ENSG00000163374	27.12	26.34	26.95	26.96	25.31	27.35	0.0263072967692014	6.22928094266333	0.686712026242678	0.911383014624408	1:155659442-155689000:-	YY1AP1	12;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008283,biological_process cell proliferation;GO:0030154,biological_process cell differentiation;GO:0031011,cellular_component Ino80 complex;GO:0051726,biological_process regulation of cell cycle	NA	YY1 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30935]
ENSG00000068784	5.21	5.79	4.76	5.49	5.64	5.21	-0.0479398556500486	4.00784984528075	0.686785561585277	0.911383014624408	2:45388679-45612165:-	SRBD1	3;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0006139,biological_process nucleobase-containing compound metabolic process	NA	S1 RNA binding domain 1 [Source:HGNC Symbol%3BAcc:HGNC:25521]
ENSG00000165501	11.15	11.67	11.45	12.16	11.80	11.52	-0.0403276877101698	3.95165376382855	0.686858336595995	0.911383014624408	14:49598696-49614672:+	LRR1	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0016853,molecular_function isomerase activity;GO:0043687,biological_process post-translational protein modification	NA	leucine rich repeat protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19742]
ENSG00000102048	3.42	6.84	5.91	3.91	5.79	5.44	0.0909520202628823	2.45550948260967	0.686859590897554	0.911383014624408	X:15235287-15270467:-	ASB9	8;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification;GO:0045732,biological_process positive regulation of protein catabolic process	NA	ankyrin repeat and SOCS box containing 9 [Source:HGNC Symbol%3BAcc:HGNC:17184]
ENSG00000184708	16.55	17.27	15.89	16.47	18.48	16.22	-0.0315161891129415	5.65245177758146	0.68707585044209	0.911473158659718	22:31436976-31496108:-	EIF4ENIF1	19;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006413,biological_process translational initiation;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0017148,biological_process negative regulation of translation;GO:0019827,biological_process stem cell population maintenance;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045665,biological_process negative regulation of neuron differentiation	NA	eukaryotic translation initiation factor 4E nuclear import factor 1 [Source:HGNC Symbol%3BAcc:HGNC:16687]
ENSG00000091009	1.95	1.98	1.62	1.81	1.96	2.08	-0.0687371762694368	2.63105740852558	0.687132109121593	0.911473158659718	5:146203599-146289132:+	RBM27	7;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding	NA	RNA binding motif protein 27 [Source:HGNC Symbol%3BAcc:HGNC:29243]
ENSG00000132323	21.36	22.79	24.93	24.09	20.42	23.33	0.0370193837016354	4.8946280691505	0.687170181536782	0.911473158659718	2:238170400-238203729:-	ILKAP	12;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding	NA	ILK associated serine/threonine phosphatase [Source:HGNC Symbol%3BAcc:HGNC:15566]
ENSG00000198793	9.69	11.08	9.87	10.99	10.50	10.01	-0.0312185415159535	6.30970775421902	0.687221243204407	0.911473158659718	1:11106534-11262507:-	MTOR	150;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0001030,molecular_function RNA polymerase III type 1 promoter DNA binding;GO:0001031,molecular_function RNA polymerase III type 2 promoter DNA binding;GO:0001032,molecular_function RNA polymerase III type 3 promoter DNA binding;GO:0001156,molecular_function TFIIIC-class transcription factor binding;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0003007,biological_process heart morphogenesis;GO:0003179,biological_process heart valve morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005942,cellular_component phosphatidylinositol 3-kinase complex;GO:0005979,biological_process regulation of glycogen biosynthetic process;GO:0006109,biological_process regulation of carbohydrate metabolic process;GO:0006112,biological_process energy reserve metabolic process;GO:0006207,biological_process 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006281,biological_process DNA repair;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007281,biological_process germ cell development;GO:0007420,biological_process brain development;GO:0007569,biological_process cell aging;GO:0007584,biological_process response to nutrient;GO:0007616,biological_process long-term memory;GO:0008361,biological_process regulation of cell size;GO:0008542,biological_process visual learning;GO:0009267,biological_process cellular response to starvation;GO:0009791,biological_process post-embryonic development;GO:0010507,biological_process negative regulation of autophagy;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0010628,biological_process positive regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010831,biological_process positive regulation of myotube differentiation;GO:0010942,biological_process positive regulation of cell death;GO:0010976,biological_process positive regulation of neuron projection development;GO:0012505,cellular_component endomembrane system;GO:0014042,biological_process positive regulation of neuron maturation;GO:0014736,biological_process negative regulation of muscle atrophy;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016241,biological_process regulation of macroautophagy;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0021510,biological_process spinal cord development;GO:0030030,biological_process cell projection organization;GO:0030163,biological_process protein catabolic process;GO:0030425,cellular_component dendrite;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031090,cellular_component organelle membrane;GO:0031295,biological_process T cell costimulation;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031529,biological_process ruffle organization;GO:0031641,biological_process regulation of myelination;GO:0031669,biological_process cellular response to nutrient levels;GO:0031929,biological_process TOR signaling;GO:0031931,cellular_component TORC1 complex;GO:0031932,cellular_component TORC2 complex;GO:0031998,biological_process regulation of fatty acid beta-oxidation;GO:0032095,biological_process regulation of response to food;GO:0032868,biological_process response to insulin;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0032991,cellular_component macromolecular complex;GO:0034198,biological_process cellular response to amino acid starvation;GO:0035176,biological_process social behavior;GO:0035264,biological_process multicellular organism growth;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038202,biological_process TORC1 signaling;GO:0040007,biological_process growth;GO:0042060,biological_process wound healing;GO:0042220,biological_process response to cocaine;GO:0043022,molecular_function ribosome binding;GO:0043025,cellular_component neuronal cell body;GO:0043087,biological_process regulation of GTPase activity;GO:0043200,biological_process response to amino acid;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043276,biological_process anoikis;GO:0043278,biological_process response to morphine;GO:0043610,biological_process regulation of carbohydrate utilization;GO:0044877,molecular_function macromolecular complex binding;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045727,biological_process positive regulation of translation;GO:0045792,biological_process negative regulation of cell size;GO:0045859,biological_process regulation of protein kinase activity;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0046777,biological_process protein autophosphorylation;GO:0046889,biological_process positive regulation of lipid biosynthetic process;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048255,biological_process mRNA stabilization;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0048738,biological_process cardiac muscle tissue development;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050769,biological_process positive regulation of neurogenesis;GO:0050882,biological_process voluntary musculoskeletal movement;GO:0051219,molecular_function phosphoprotein binding;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051534,biological_process negative regulation of NFAT protein import into nucleus;GO:0051549,biological_process positive regulation of keratinocyte migration;GO:0051896,biological_process regulation of protein kinase B signaling;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0055006,biological_process cardiac cell development;GO:0055013,biological_process cardiac muscle cell development;GO:0060048,biological_process cardiac muscle contraction;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0061051,biological_process positive regulation of cell growth involved in cardiac muscle cell development;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071233,biological_process cellular response to leucine;GO:0071456,biological_process cellular response to hypoxia;GO:0090335,biological_process regulation of brown fat cell differentiation;GO:0090559,biological_process regulation of membrane permeability;GO:1900034,biological_process regulation of cellular response to heat;GO:1901216,biological_process positive regulation of neuron death;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1903691,biological_process positive regulation of wound healing, spreading of epidermal cells;GO:1904000,biological_process positive regulation of eating behavior;GO:1904056,biological_process positive regulation of cholangiocyte proliferation;GO:1904058,biological_process positive regulation of sensory perception of pain;GO:1904193,biological_process negative regulation of cholangiocyte apoptotic process;GO:1904197,biological_process positive regulation of granulosa cell proliferation;GO:1904206,biological_process positive regulation of skeletal muscle hypertrophy;GO:1904213,biological_process negative regulation of iodide transmembrane transport;GO:1990253,biological_process cellular response to leucine starvation	MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]; K07203	mechanistic target of rapamycin [Source:HGNC Symbol%3BAcc:HGNC:3942]
ENSG00000173581	9.84	12.86	12.00	12.39	12.01	11.80	-0.0601351137518877	3.32861341642646	0.687371278719645	0.911478687370724	19:55641061-55653161:+	CCDC106	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol	NA	coiled-coil domain containing 106 [Source:HGNC Symbol%3BAcc:HGNC:30181]
ENSG00000108406	42.37	42.73	40.72	42.32	42.97	43.81	-0.0260817119538073	6.63658714969673	0.687372270400173	0.911478687370724	17:59565524-59608345:+	DHX40	11;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0016787,molecular_function hydrolase activity	NA	DEAH-box helicase 40 [Source:HGNC Symbol%3BAcc:HGNC:18018]
ENSG00000169193	2.86	2.50	2.98	2.50	2.35	2.68	0.167983237222553	0.340898717238037	0.687493592141384	0.911542187486755	7:23597378-23644708:+	CCDC126	5;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0006487,biological_process protein N-linked glycosylation;GO:0016020,cellular_component membrane;GO:0030144,molecular_function alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	NA	coiled-coil domain containing 126 [Source:HGNC Symbol%3BAcc:HGNC:22398]
ENSG00000011243	39.73	34.39	39.67	36.87	34.96	40.53	0.0323699709057743	6.35574738466006	0.687721325850247	0.911683151944839	19:15380047-15419141:-	AKAP8L	28;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0007076,biological_process mitotic chromosome condensation;GO:0008150,biological_process biological_process;GO:0008380,biological_process RNA splicing;GO:0010793,biological_process regulation of mRNA export from nucleus;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016363,cellular_component nuclear matrix;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0017151,molecular_function DEAD/H-box RNA helicase binding;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0033127,biological_process regulation of histone phosphorylation;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0042826,molecular_function histone deacetylase binding;GO:0044839,biological_process cell cycle G2/M phase transition;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051081,biological_process nuclear envelope disassembly	NA	A-kinase anchoring protein 8 like [Source:HGNC Symbol%3BAcc:HGNC:29857]
ENSG00000059758	13.03	13.27	11.46	12.55	13.08	13.40	-0.0405924232497988	4.42241778371228	0.687800938475606	0.911683151944839	12:96278260-96400560:-	CDK17	11;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	cyclin dependent kinase 17 [Source:HGNC Symbol%3BAcc:HGNC:8750]
ENSG00000109881	20.89	17.92	19.75	20.09	20.79	19.81	-0.0324665323566014	4.5888914130464	0.6879233749379	0.911683151944839	11:27330826-27363868:-	CCDC34	NA	NA	coiled-coil domain containing 34 [Source:HGNC Symbol%3BAcc:HGNC:25079]
ENSG00000186792	3.38	2.59	3.64	3.11	2.84	3.25	0.0912361723517652	2.04013897914146	0.687952974776239	0.911683151944839	3:50292830-50299468:-	HYAL3	19;GO:0003824,molecular_function catalytic activity;GO:0004415,molecular_function hyalurononglucosaminidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0006954,biological_process inflammatory response;GO:0008152,biological_process metabolic process;GO:0009615,biological_process response to virus;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030214,biological_process hyaluronan catabolic process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033906,molecular_function hyaluronoglucuronidase activity;GO:0046677,biological_process response to antibiotic;GO:0051216,biological_process cartilage development;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071493,biological_process cellular response to UV-B	hya; hyaluronoglucosaminidase [EC:3.2.1.35]; K01197	hyaluronoglucosaminidase 3 [Source:HGNC Symbol%3BAcc:HGNC:5322]
ENSG00000079435	0.71	0.90	0.76	0.71	0.99	0.52	0.106544770278277	1.4402742052165	0.687967138022018	0.911683151944839	19:42401506-42427426:-	LIPE	21;GO:0004806,molecular_function triglyceride lipase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006468,biological_process protein phosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016298,molecular_function lipase activity;GO:0016787,molecular_function hydrolase activity;GO:0019433,biological_process triglyceride catabolic process;GO:0019901,molecular_function protein kinase binding;GO:0033878,molecular_function hormone-sensitive lipase activity;GO:0042758,biological_process long-chain fatty acid catabolic process;GO:0046340,biological_process diacylglycerol catabolic process	LIPE, HSL; hormone-sensitive lipase [EC:3.1.1.79]; K07188	lipase E%2C hormone sensitive type [Source:HGNC Symbol%3BAcc:HGNC:6621]
ENSG00000106682	322.85	324.59	320.32	331.99	324.78	334.77	-0.0234048648521131	7.92634981648571	0.688169434463872	0.911853884500432	7:74174244-74197101:+	EIF4H	24;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016281,cellular_component eukaryotic translation initiation factor 4F complex;GO:0019953,biological_process sexual reproduction;GO:0033592,molecular_function RNA strand annealing activity;GO:0034057,molecular_function RNA strand-exchange activity;GO:0043024,molecular_function ribosomal small subunit binding;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048589,biological_process developmental growth;GO:0097010,biological_process eukaryotic translation initiation factor 4F complex assembly	NA	eukaryotic translation initiation factor 4H [Source:HGNC Symbol%3BAcc:HGNC:12741]
ENSG00000168286	17.02	16.64	17.89	16.37	15.30	18.74	0.0439203733916805	4.01686976728991	0.688268875104605	0.911888306828206	16:67842081-67844195:+	THAP11	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:23194]
ENSG00000185760	1.45	0.91	1.12	1.14	1.03	1.15	0.0966447197221364	1.91468854439866	0.688649275922378	0.912294926576786	6:72621791-73198851:+	KCNQ5	17;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030118,cellular_component clathrin coat;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport	KCNQ5, KV7.5; potassium voltage-gated channel KQT-like subfamily member 5; K04930	potassium voltage-gated channel subfamily Q member 5 [Source:HGNC Symbol%3BAcc:HGNC:6299]
ENSG00000004142	96.79	96.69	97.27	103.76	95.42	99.24	-0.0258503590364671	6.76336314148652	0.68877597832682	0.912302522948766	17:28347176-28357522:-	POLDIP2	8;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0016242,biological_process negative regulation of macroautophagy;GO:0042645,cellular_component mitochondrial nucleoid;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0070584,biological_process mitochondrion morphogenesis	NA	DNA polymerase delta interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:23781]
ENSG00000171700	3.58	4.40	3.50	3.22	3.73	3.78	0.0923307914860237	1.34908861600332	0.688802001536763	0.912302522948766	20:64073180-64079988:-	RGS19	16;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005903,cellular_component brush border;GO:0006914,biological_process autophagy;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045121,cellular_component membrane raft	NA	regulator of G protein signaling 19 [Source:HGNC Symbol%3BAcc:HGNC:13735]
ENSG00000130340	100.22	94.33	98.71	99.49	97.47	103.88	-0.0243782030881633	7.46804567139152	0.689039301203958	0.912482700431135	6:157700386-157945077:+	SNX9	39;GO:0000278,biological_process mitotic cell cycle;GO:0000281,biological_process mitotic cytokinesis;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007049,biological_process cell cycle;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032461,biological_process positive regulation of protein oligomerization;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036089,biological_process cleavage furrow formation;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0051301,biological_process cell division;GO:0060988,biological_process lipid tube assembly;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0071933,molecular_function Arp2/3 complex binding;GO:0097320,biological_process membrane tubulation	NA	sorting nexin 9 [Source:HGNC Symbol%3BAcc:HGNC:14973]
ENSG00000184995	4.64	2.76	3.42	3.24	3.16	3.83	0.114544478166831	1.24281078073129	0.68908505871598	0.912482700431135	9:21480838-21482313:-	IFNE	18;GO:0002250,biological_process adaptive immune response;GO:0002286,biological_process T cell activation involved in immune response;GO:0002323,biological_process natural killer cell activation involved in immune response;GO:0005125,molecular_function cytokine activity;GO:0005126,molecular_function cytokine receptor binding;GO:0005132,molecular_function type I interferon receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006952,biological_process defense response;GO:0006959,biological_process humoral immune response;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030183,biological_process B cell differentiation;GO:0033141,biological_process positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0042100,biological_process B cell proliferation;GO:0042742,biological_process defense response to bacterium;GO:0043330,biological_process response to exogenous dsRNA;GO:0045087,biological_process innate immune response;GO:0051607,biological_process defense response to virus	IFNE; interferon epsilon; K05442	interferon epsilon [Source:HGNC Symbol%3BAcc:HGNC:18163]
ENSG00000102934	11.59	11.05	10.73	11.54	11.69	11.78	-0.0563157933327509	2.80015989367512	0.689269214116274	0.912495491302728	16:57248546-57284687:-	PLLP	13;GO:0001766,biological_process membrane raft polarization;GO:0005515,molecular_function protein binding;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008104,biological_process protein localization;GO:0009611,biological_process response to wounding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019911,molecular_function structural constituent of myelin sheath;GO:0042552,biological_process myelination;GO:0043218,cellular_component compact myelin;GO:0045121,cellular_component membrane raft;GO:0070062,cellular_component extracellular exosome	NA	plasmolipin [Source:HGNC Symbol%3BAcc:HGNC:18553]
ENSG00000099860	102.02	86.14	109.08	112.95	90.32	104.76	-0.0368093219315873	6.01731092184176	0.689296067605943	0.912495491302728	19:2476121-2478259:+	GADD45B	14;GO:0000185,biological_process activation of MAPKKK activity;GO:0000186,biological_process activation of MAPKK activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046330,biological_process positive regulation of JNK cascade;GO:0051726,biological_process regulation of cell cycle;GO:1900745,biological_process positive regulation of p38MAPK cascade	GADD45; growth arrest and DNA-damage-inducible protein; K04402	growth arrest and DNA damage inducible beta [Source:HGNC Symbol%3BAcc:HGNC:4096]
ENSG00000244687	5.31	5.11	5.91	4.88	4.57	6.00	0.0932222975275074	1.73563289438276	0.68931525190894	0.912495491302728	20:50081123-50115959:-	UBE2V1	27;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000187,biological_process activation of MAPK activity;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006282,biological_process regulation of DNA repair;GO:0006301,biological_process postreplication repair;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007254,biological_process JNK cascade;GO:0030154,biological_process cell differentiation;GO:0031371,cellular_component ubiquitin conjugating enzyme complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035370,cellular_component UBC13-UEV1A complex;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070534,biological_process protein K63-linked ubiquitination	UBE2V; ubiquitin-conjugating enzyme E2 variant; K10704	ubiquitin conjugating enzyme E2 V1 [Source:HGNC Symbol%3BAcc:HGNC:12494]
ENSG00000234857	0.41	0.17	0.53	0.67	0.37	0.25	-0.154892845501008	0.0888677269834108	0.689558700010074	0.912720424741421	11:62690274-62727384:-	HNRNPUL2-BSCL2	NA	NA	HNRNPUL2-BSCL2 readthrough (NMD candidate) [Source:HGNC Symbol%3BAcc:HGNC:49189]
ENSG00000115183	9.31	10.77	9.85	9.58	10.41	9.52	0.0286888453333442	5.79194191695433	0.689777786655922	0.912913068105337	2:158968670-159232659:+	TANC1	12;GO:0005886,cellular_component plasma membrane;GO:0007520,biological_process myoblast fusion;GO:0008542,biological_process visual learning;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0043025,cellular_component neuronal cell body;GO:0043679,cellular_component axon terminus;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0097062,biological_process dendritic spine maintenance	NA	tetratricopeptide repeat%2C ankyrin repeat and coiled-coil containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29364]
ENSG00000130731	31.99	29.65	36.84	32.62	31.57	38.01	-0.0384199215312783	4.96278011058076	0.690049211676865	0.913174932254256	16:634426-636366:-	METTL26	NA	NA	methyltransferase like 26 [Source:HGNC Symbol%3BAcc:HGNC:14141]
ENSG00000163001	41.17	38.39	41.14	41.91	39.05	43.25	-0.0274613352470873	5.67616914545087	0.690342563141194	0.913401325049446	2:55519603-55545879:+	CFAP36	3;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0042995,cellular_component cell projection	NA	cilia and flagella associated protein 36 [Source:HGNC Symbol%3BAcc:HGNC:30540]
ENSG00000185220	3.90	3.50	3.48	3.63	3.72	3.17	0.0681707456864906	2.69732362850298	0.690396297613316	0.913401325049446	1:248906195-248919946:+	PGBD2	NA	NA	piggyBac transposable element derived 2 [Source:HGNC Symbol%3BAcc:HGNC:19399]
ENSG00000164061	0.03	0.09	0.12	0.04	0.09	0.08	0.198160860843809	0.0197096102896532	0.690529665511539	0.913401325049446	3:49554488-49671545:+	BSN	21;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007268,biological_process chemical synaptic transmission;GO:0007416,biological_process synapse assembly;GO:0009986,cellular_component cell surface;GO:0014069,cellular_component postsynaptic density;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0035418,biological_process protein localization to synapse;GO:0043005,cellular_component neuron projection;GO:0044306,cellular_component neuron projection terminus;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0048786,cellular_component presynaptic active zone;GO:0048788,cellular_component cytoskeleton of presynaptic active zone;GO:0060076,cellular_component excitatory synapse;GO:0098793,cellular_component presynapse;GO:0098831,cellular_component presynaptic active zone cytoplasmic component;GO:0099526,biological_process presynapse to nucleus signaling pathway	NA	bassoon presynaptic cytomatrix protein [Source:HGNC Symbol%3BAcc:HGNC:1117]
ENSG00000181220	6.40	5.76	5.92	5.72	6.18	6.94	-0.0455971351139687	3.62615481752172	0.690581636381757	0.913401325049446	7:149472793-149497817:-	ZNF746	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1901216,biological_process positive regulation of neuron death	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 746 [Source:HGNC Symbol%3BAcc:HGNC:21948]
ENSG00000104447	4.39	4.52	4.60	4.51	4.64	4.11	0.0403110083278207	4.15887832733261	0.690588208780235	0.913401325049446	8:115408495-115809673:-	TRPS1	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0008270,molecular_function zinc ion binding;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0043234,cellular_component protein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051291,biological_process protein heterooligomerization	NA	transcriptional repressor GATA binding 1 [Source:HGNC Symbol%3BAcc:HGNC:12340]
ENSG00000164237	55.92	58.90	55.08	52.87	62.12	59.99	-0.0331016550469381	5.40605997972753	0.690712232117877	0.913468030820286	5:10275874-10308026:-	CMBL	5;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006805,biological_process xenobiotic metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	carboxymethylenebutenolidase homolog [Source:HGNC Symbol%3BAcc:HGNC:25090]
ENSG00000126653	25.65	24.87	28.05	27.53	23.60	26.41	0.0323599806784884	5.70896873286788	0.690806664606417	0.913495592602477	17:30115520-30186475:+	NSRP1	12;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006397,biological_process mRNA processing;GO:0006913,biological_process nucleocytoplasmic transport;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032502,biological_process developmental process	NA	nuclear speckle splicing regulatory protein 1 [Source:HGNC Symbol%3BAcc:HGNC:25305]
ENSG00000163131	1.71	2.06	1.98	1.88	1.09	2.34	0.111454429347023	1.14017759804299	0.691123682738532	0.913781539413214	1:150730195-150765957:-	CTSS	33;GO:0001968,molecular_function fibronectin binding;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0006955,biological_process immune response;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010447,biological_process response to acidic pH;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0019882,biological_process antigen processing and presentation;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0022617,biological_process extracellular matrix disassembly;GO:0030574,biological_process collagen catabolic process;GO:0034769,biological_process basement membrane disassembly;GO:0036021,cellular_component endolysosome lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043236,molecular_function laminin binding;GO:0043312,biological_process neutrophil degranulation;GO:0043394,molecular_function proteoglycan binding;GO:0048002,biological_process antigen processing and presentation of peptide antigen;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2001259,biological_process positive regulation of cation channel activity	CTSS; cathepsin S [EC:3.4.22.27]; K01368	cathepsin S [Source:HGNC Symbol%3BAcc:HGNC:2545]
ENSG00000125753	60.57	58.13	62.91	64.16	59.76	62.63	-0.0256195094229988	6.36035281753808	0.691201935391902	0.913781539413214	19:45506578-45526983:+	VASP	27;GO:0001843,biological_process neural tube closure;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0005925,cellular_component focal adhesion;GO:0007411,biological_process axon guidance;GO:0008154,biological_process actin polymerization or depolymerization;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031258,cellular_component lamellipodium membrane;GO:0031527,cellular_component filopodium membrane;GO:0034329,biological_process cell junction assembly;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0051289,biological_process protein homotetramerization;GO:0070062,cellular_component extracellular exosome	VASP; vasodilator-stimulated phosphoprotein; K06274	vasodilator stimulated phosphoprotein [Source:HGNC Symbol%3BAcc:HGNC:12652]
ENSG00000184990	45.01	37.53	41.27	40.11	42.27	45.98	-0.0349170797100932	4.67215179021916	0.691398886699804	0.913781539413214	14:104753099-104768494:+	SIVA1	13;GO:0001618,molecular_function virus receptor activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005175,molecular_function CD27 receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0016032,biological_process viral process;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0097191,biological_process extrinsic apoptotic signaling pathway	NA	SIVA1 apoptosis inducing factor [Source:HGNC Symbol%3BAcc:HGNC:17712]
ENSG00000149679	3.20	2.33	2.51	2.61	3.17	1.81	0.11111469198174	1.96385094659346	0.691406039463753	0.913781539413214	20:62388631-62407285:-	CABLES2	3;GO:0007049,biological_process cell cycle;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	NA	Cdk5 and Abl enzyme substrate 2 [Source:HGNC Symbol%3BAcc:HGNC:16143]
ENSG00000136935	9.13	9.01	8.34	9.10	7.48	9.34	0.0403877971013224	4.34726624932636	0.691437664320916	0.913781539413214	9:124878356-124948492:-	GOLGA1	8;GO:0000042,biological_process protein targeting to Golgi;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0032580,cellular_component Golgi cisterna membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	golgin A1 [Source:HGNC Symbol%3BAcc:HGNC:4424]
ENSG00000127564	15.65	17.77	14.41	15.55	16.58	17.19	-0.0394305220426214	5.03437136317889	0.691464593547758	0.913781539413214	16:2968023-2980539:-	PKMYT1	27;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0051726,biological_process regulation of cell cycle	PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]; K06633	protein kinase%2C membrane associated tyrosine/threonine 1 [Source:HGNC Symbol%3BAcc:HGNC:29650]
ENSG00000126456	38.60	40.82	40.97	37.69	41.20	40.19	0.0264044890156494	5.89031004070084	0.691748378810025	0.914059253371178	19:49659568-49665875:-	IRF3	49;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000975,molecular_function regulatory region DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009617,biological_process response to bacterium;GO:0016032,biological_process viral process;GO:0019904,molecular_function protein domain specific binding;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032479,biological_process regulation of type I interferon production;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032496,biological_process response to lipopolysaccharide;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0039530,biological_process MDA-5 signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043330,biological_process response to exogenous dsRNA;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045087,biological_process innate immune response;GO:0045351,biological_process type I interferon biosynthetic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050715,biological_process positive regulation of cytokine secretion;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071359,biological_process cellular response to dsRNA;GO:0071888,biological_process macrophage apoptotic process;GO:0097300,biological_process programmed necrotic cell death	IRF3; interferon regulatory factor 3; K05411	interferon regulatory factor 3 [Source:HGNC Symbol%3BAcc:HGNC:6118]
ENSG00000101298	2.36	3.20	2.42	1.95	2.58	2.96	0.0809653512742249	2.09952648920364	0.692051096744724	0.914305399104097	20:1266315-1309328:+	SNPH	17;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0007269,biological_process neurotransmitter secretion;GO:0007420,biological_process brain development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016081,biological_process synaptic vesicle docking;GO:0017075,molecular_function syntaxin-1 binding;GO:0030054,cellular_component cell junction;GO:0030182,biological_process neuron differentiation;GO:0031966,cellular_component mitochondrial membrane;GO:0042734,cellular_component presynaptic membrane;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0045202,cellular_component synapse	NA	syntaphilin [Source:HGNC Symbol%3BAcc:HGNC:15931]
ENSG00000161980	14.82	13.57	16.36	17.79	15.92	13.89	-0.0664841020435595	2.36567116854363	0.692081972930162	0.914305399104097	16:46406-53628:-	POLR3K	18;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006379,biological_process mRNA cleavage;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0006386,biological_process termination of RNA polymerase III transcription;GO:0008270,molecular_function zinc ion binding;GO:0032481,biological_process positive regulation of type I interferon production;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus	RPC11, POLR3K; DNA-directed RNA polymerase III subunit RPC11; K03019	RNA polymerase III subunit K [Source:HGNC Symbol%3BAcc:HGNC:14121]
ENSG00000177728	12.56	12.94	14.28	12.70	13.76	14.50	-0.0303089626046591	5.82443524537067	0.692294153176857	0.914433882648279	17:75441158-75500090:+	TMEM94	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 94 [Source:HGNC Symbol%3BAcc:HGNC:28983]
ENSG00000100280	18.83	21.50	18.24	19.32	20.87	17.43	0.0324931660048473	5.92956318699187	0.692386858526006	0.914433882648279	22:29327679-29423179:-	AP1B1	25;GO:0000139,cellular_component Golgi membrane;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019901,molecular_function protein kinase binding;GO:0030117,cellular_component membrane coat;GO:0030131,cellular_component clathrin adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050690,biological_process regulation of defense response to virus by virus	AP1B1; AP-1 complex subunit beta-1; K12392	adaptor related protein complex 1 beta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:554]
ENSG00000160972	29.78	28.84	30.90	30.01	28.49	30.10	0.0282663292350776	5.56158256600822	0.692400230646191	0.914433882648279	8:144477968-144502121:+	PPP1R16A	5;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0050790,biological_process regulation of catalytic activity	NA	protein phosphatase 1 regulatory subunit 16A [Source:HGNC Symbol%3BAcc:HGNC:14941]
ENSG00000167397	0.72	0.98	1.01	0.96	1.10	1.02	-0.184743011483466	0.355609644814379	0.692551652138213	0.914465995524272	16:31090841-31095980:-	VKORC1	13;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0017144,biological_process drug metabolic process;GO:0017187,biological_process peptidyl-glutamic acid carboxylation;GO:0042373,biological_process vitamin K metabolic process;GO:0047057,molecular_function vitamin-K-epoxide reductase (warfarin-sensitive) activity;GO:0048038,molecular_function quinone binding;GO:0055114,biological_process oxidation-reduction process;GO:0060348,biological_process bone development	VKORC1; vitamin-K-epoxide reductase (warfarin-sensitive) [EC:1.17.4.4]; K05357	vitamin K epoxide reductase complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:23663]
ENSG00000050327	6.19	7.44	6.91	7.31	6.81	7.05	-0.037274882832102	5.06274853449228	0.69257188624214	0.914465995524272	7:144355287-144380632:+	ARHGEF5	29;GO:0002102,cellular_component podosome;GO:0002408,biological_process myeloid dendritic cell chemotaxis;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008289,molecular_function lipid binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0071803,biological_process positive regulation of podosome assembly;GO:0071944,cellular_component cell periphery;GO:1904591,biological_process positive regulation of protein import	NA	Rho guanine nucleotide exchange factor 5 [Source:HGNC Symbol%3BAcc:HGNC:13209]
ENSG00000148335	26.51	26.36	22.50	24.42	25.64	23.78	0.0388722652014991	4.38360256661347	0.692711979550916	0.914553690934431	9:129608883-129636131:+	NTMT1	20;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006480,biological_process N-terminal protein amino acid methylation;GO:0007051,biological_process spindle organization;GO:0007059,biological_process chromosome segregation;GO:0008168,molecular_function methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018011,biological_process N-terminal peptidyl-alanine methylation;GO:0018012,biological_process N-terminal peptidyl-alanine trimethylation;GO:0018013,biological_process N-terminal peptidyl-glycine methylation;GO:0018016,biological_process N-terminal peptidyl-proline dimethylation;GO:0032259,biological_process methylation;GO:0035572,biological_process N-terminal peptidyl-serine dimethylation;GO:0035573,biological_process N-terminal peptidyl-serine trimethylation;GO:0042054,molecular_function histone methyltransferase activity;GO:0071885,molecular_function N-terminal protein N-methyltransferase activity	NA	N-terminal Xaa-Pro-Lys N-methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:23373]
ENSG00000111860	2.08	1.35	1.88	1.56	1.67	2.51	-0.0883601361129945	2.29380125400776	0.692951318353947	0.914693776511803	6:118460771-118710075:-	CEP85L	4;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton	NA	centrosomal protein 85 like [Source:HGNC Symbol%3BAcc:HGNC:21638]
ENSG00000148331	8.44	9.91	10.72	8.48	9.85	9.91	0.050354784246205	3.60958771099172	0.693038469234628	0.914693776511803	9:129634603-129642169:-	ASB6	7;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	ankyrin repeat and SOCS box containing 6 [Source:HGNC Symbol%3BAcc:HGNC:17181]
ENSG00000183605	17.12	16.26	17.11	17.48	16.73	18.08	-0.036826070754623	4.12954353890867	0.693103950078826	0.914693776511803	10:119140766-119165667:-	SFXN4	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015075,molecular_function ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0055072,biological_process iron ion homeostasis;GO:0055085,biological_process transmembrane transport	NA	sideroflexin 4 [Source:HGNC Symbol%3BAcc:HGNC:16088]
ENSG00000256223	1.89	2.84	1.97	2.22	2.07	2.00	0.074278491116288	1.93797638957547	0.693249601493017	0.914693776511803	12:133130574-133159465:+	ZNF10	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 10 [Source:HGNC Symbol%3BAcc:HGNC:12879]
ENSG00000005889	5.86	5.17	5.00	4.55	6.08	4.97	0.0542525456918966	3.75640769172584	0.693334984407123	0.914693776511803	X:24149172-24216255:+	ZFX	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:12869]
ENSG00000152990	16.15	16.83	16.73	16.19	15.76	17.24	0.0254474087552204	6.06198886443881	0.693371829754656	0.914693776511803	4:22345070-22516054:-	ADGRA3	9;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	adhesion G protein-coupled receptor A3 [Source:HGNC Symbol%3BAcc:HGNC:13839]
ENSG00000125378	4.07	4.62	4.42	3.91	5.38	4.60	-0.0771998279094197	2.56511353997278	0.693444283797862	0.914693776511803	14:53949735-53958761:-	BMP4	208;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000186,biological_process activation of MAPKK activity;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001525,biological_process angiogenesis;GO:0001568,biological_process blood vessel development;GO:0001649,biological_process osteoblast differentiation;GO:0001656,biological_process metanephros development;GO:0001657,biological_process ureteric bud development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001707,biological_process mesoderm formation;GO:0001759,biological_process organ induction;GO:0001822,biological_process kidney development;GO:0001823,biological_process mesonephros development;GO:0001843,biological_process neural tube closure;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001944,biological_process vasculature development;GO:0001958,biological_process endochondral ossification;GO:0002043,biological_process blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0002062,biological_process chondrocyte differentiation;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002320,biological_process lymphoid progenitor cell differentiation;GO:0003014,biological_process renal system process;GO:0003130,biological_process BMP signaling pathway involved in heart induction;GO:0003139,biological_process secondary heart field specification;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003149,biological_process membranous septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003180,biological_process aortic valve morphogenesis;GO:0003184,biological_process pulmonary valve morphogenesis;GO:0003197,biological_process endocardial cushion development;GO:0003279,biological_process cardiac septum development;GO:0003323,biological_process type B pancreatic cell development;GO:0003337,biological_process mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0007182,biological_process common-partner SMAD protein phosphorylation;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007281,biological_process germ cell development;GO:0007492,biological_process endoderm development;GO:0007500,biological_process mesodermal cell fate determination;GO:0007507,biological_process heart development;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009791,biological_process post-embryonic development;GO:0009888,biological_process tissue development;GO:0009948,biological_process anterior/posterior axis specification;GO:0010159,biological_process specification of organ position;GO:0010453,biological_process regulation of cell fate commitment;GO:0010468,biological_process regulation of gene expression;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0010942,biological_process positive regulation of cell death;GO:0021537,biological_process telencephalon development;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021978,biological_process telencephalon regionalization;GO:0021983,biological_process pituitary gland development;GO:0030154,biological_process cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030224,biological_process monocyte differentiation;GO:0030225,biological_process macrophage differentiation;GO:0030324,biological_process lung development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030335,biological_process positive regulation of cell migration;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030900,biological_process forebrain development;GO:0032092,biological_process positive regulation of protein binding;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0033085,biological_process negative regulation of T cell differentiation in thymus;GO:0033088,biological_process negative regulation of immature T cell proliferation in thymus;GO:0034504,biological_process protein localization to nucleus;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035990,biological_process tendon cell differentiation;GO:0035993,biological_process deltoid tuberosity development;GO:0039706,molecular_function co-receptor binding;GO:0042056,molecular_function chemoattractant activity;GO:0042306,biological_process regulation of protein import into nucleus;GO:0042326,biological_process negative regulation of phosphorylation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042476,biological_process odontogenesis;GO:0042487,biological_process regulation of odontogenesis of dentin-containing tooth;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043010,biological_process camera-type eye development;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045165,biological_process cell fate commitment;GO:0045595,biological_process regulation of cell differentiation;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045603,biological_process positive regulation of endothelial cell differentiation;GO:0045606,biological_process positive regulation of epidermal cell differentiation;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045778,biological_process positive regulation of ossification;GO:0045786,biological_process negative regulation of cell cycle;GO:0045839,biological_process negative regulation of mitotic nuclear division;GO:0045843,biological_process negative regulation of striated muscle tissue development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048286,biological_process lung alveolus development;GO:0048333,biological_process mesodermal cell differentiation;GO:0048392,biological_process intermediate mesodermal cell differentiation;GO:0048593,biological_process camera-type eye morphogenesis;GO:0048598,biological_process embryonic morphogenesis;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048660,biological_process regulation of smooth muscle cell proliferation;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0048663,biological_process neuron fate commitment;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0048745,biological_process smooth muscle tissue development;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050918,biological_process positive chemotaxis;GO:0051145,biological_process smooth muscle cell differentiation;GO:0051150,biological_process regulation of smooth muscle cell differentiation;GO:0051216,biological_process cartilage development;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055020,biological_process positive regulation of cardiac muscle fiber development;GO:0060113,biological_process inner ear receptor cell differentiation;GO:0060197,biological_process cloacal septation;GO:0060235,biological_process lens induction in camera-type eye;GO:0060272,biological_process embryonic skeletal joint morphogenesis;GO:0060348,biological_process bone development;GO:0060363,biological_process cranial suture morphogenesis;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060393,biological_process regulation of pathway-restricted SMAD protein phosphorylation;GO:0060395,biological_process SMAD protein signal transduction;GO:0060425,biological_process lung morphogenesis;GO:0060429,biological_process epithelium development;GO:0060433,biological_process bronchus development;GO:0060438,biological_process trachea development;GO:0060440,biological_process trachea formation;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060442,biological_process branching involved in prostate gland morphogenesis;GO:0060449,biological_process bud elongation involved in lung branching;GO:0060502,biological_process epithelial cell proliferation involved in lung morphogenesis;GO:0060503,biological_process bud dilation involved in lung branching;GO:0060512,biological_process prostate gland morphogenesis;GO:0060548,biological_process negative regulation of cell death;GO:0060592,biological_process mammary gland formation;GO:0060684,biological_process epithelial-mesenchymal cell signaling;GO:0060686,biological_process negative regulation of prostatic bud formation;GO:0060687,biological_process regulation of branching involved in prostate gland morphogenesis;GO:0060688,biological_process regulation of morphogenesis of a branching structure;GO:0060976,biological_process coronary vasculature development;GO:0061035,biological_process regulation of cartilage development;GO:0061036,biological_process positive regulation of cartilage development;GO:0061047,biological_process positive regulation of branching involved in lung morphogenesis;GO:0061149,biological_process BMP signaling pathway involved in ureter morphogenesis;GO:0061151,biological_process BMP signaling pathway involved in renal system segmentation;GO:0061155,biological_process pulmonary artery endothelial tube morphogenesis;GO:0061312,biological_process BMP signaling pathway involved in heart development;GO:0061626,biological_process pharyngeal arch artery morphogenesis;GO:0070244,biological_process negative regulation of thymocyte apoptotic process;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070700,molecular_function BMP receptor binding;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071773,biological_process cellular response to BMP stimulus;GO:0071893,biological_process BMP signaling pathway involved in nephric duct formation;GO:0072001,biological_process renal system development;GO:0072015,biological_process glomerular visceral epithelial cell development;GO:0072097,biological_process negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway;GO:0072101,biological_process specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway;GO:0072104,biological_process glomerular capillary formation;GO:0072125,biological_process negative regulation of glomerular mesangial cell proliferation;GO:0072138,biological_process mesenchymal cell proliferation involved in ureteric bud development;GO:0072161,biological_process mesenchymal cell differentiation involved in kidney development;GO:0072192,biological_process ureter epithelial cell differentiation;GO:0072193,biological_process ureter smooth muscle cell differentiation;GO:0072198,biological_process mesenchymal cell proliferation involved in ureter development;GO:0072200,biological_process negative regulation of mesenchymal cell proliferation involved in ureter development;GO:0072205,biological_process metanephric collecting duct development;GO:0090184,biological_process positive regulation of kidney development;GO:0090191,biological_process negative regulation of branching involved in ureteric bud morphogenesis;GO:0090194,biological_process negative regulation of glomerulus development;GO:1901964,biological_process positive regulation of cell proliferation involved in outflow tract morphogenesis;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903800,biological_process positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1905312,Biological_Process positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:2000005,biological_process negative regulation of metanephric S-shaped body morphogenesis;GO:2000007,biological_process negative regulation of metanephric comma-shaped body morphogenesis;GO:2000105,biological_process positive regulation of DNA-dependent DNA replication;GO:2000137,biological_process negative regulation of cell proliferation involved in heart morphogenesis;GO:2001012,biological_process mesenchymal cell differentiation involved in renal system development;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	BMP4; bone morphogenetic protein 4; K04662	bone morphogenetic protein 4 [Source:HGNC Symbol%3BAcc:HGNC:1071]
ENSG00000114770	8.79	8.52	7.59	8.26	7.87	8.42	0.0305169071114426	5.29163091903179	0.693492631334611	0.914693776511803	3:183919933-184018015:-	ABCC5	15;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008514,molecular_function organic anion transmembrane transporter activity;GO:0015711,biological_process organic anion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0030213,biological_process hyaluronan biosynthetic process;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0043225,molecular_function anion transmembrane-transporting ATPase activity;GO:0055085,biological_process transmembrane transport;GO:0099133,biological_process ATP hydrolysis coupled anion transmembrane transport	ABCC5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; K05668	ATP binding cassette subfamily C member 5 [Source:HGNC Symbol%3BAcc:HGNC:56]
ENSG00000174839	10.24	11.03	10.43	10.97	9.77	10.34	0.0354615829243137	4.29492670331034	0.693508871456839	0.914693776511803	3:57625456-57693089:-	DENND6A	10;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0055037,cellular_component recycling endosome;GO:0061024,biological_process membrane organization;GO:2000049,biological_process positive regulation of cell-cell adhesion mediated by cadherin	NA	DENN domain containing 6A [Source:HGNC Symbol%3BAcc:HGNC:26635]
ENSG00000138593	11.56	12.84	13.00	12.19	13.33	12.97	-0.0318673721838723	5.40373815120234	0.693554968543389	0.914693776511803	15:48988475-49046563:-	SECISBP2L	7;GO:0001514,biological_process selenocysteine incorporation;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035368,molecular_function selenocysteine insertion sequence binding;GO:0043021,molecular_function ribonucleoprotein complex binding	NA	SECIS binding protein 2 like [Source:HGNC Symbol%3BAcc:HGNC:28997]
ENSG00000100949	8.36	8.65	8.50	7.90	9.63	7.34	0.0480270765279029	3.86888187980065	0.693847413085636	0.914769804504958	14:24265537-24271739:-	RABGGTA	17;GO:0004659,molecular_function prenyltransferase activity;GO:0004663,molecular_function Rab geranylgeranyltransferase activity;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005968,cellular_component Rab-protein geranylgeranyltransferase complex;GO:0006461,biological_process protein complex assembly;GO:0006464,biological_process cellular protein modification process;GO:0007601,biological_process visual perception;GO:0008270,molecular_function zinc ion binding;GO:0008318,molecular_function protein prenyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0018342,biological_process protein prenylation;GO:0018344,biological_process protein geranylgeranylation;GO:0042981,biological_process regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0046982,molecular_function protein heterodimerization activity	NA	Rab geranylgeranyltransferase alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:9795]
ENSG00000145782	55.41	62.49	60.86	62.35	60.53	61.12	-0.0341326650212251	4.98090949588992	0.693970168918381	0.914769804504958	5:115828199-115841858:-	ATG12	18;GO:0000045,biological_process autophagosome assembly;GO:0000422,biological_process mitophagy;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006501,biological_process C-terminal protein lipidation;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0019776,molecular_function Atg8 ligase activity;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0034274,cellular_component Atg12-Atg5-Atg16 complex;GO:0043234,cellular_component protein complex;GO:0044804,biological_process nucleophagy;GO:0045087,biological_process innate immune response	ATG12; ubiquitin-like protein ATG12; K08336	autophagy related 12 [Source:HGNC Symbol%3BAcc:HGNC:588]
ENSG00000116580	9.18	9.20	8.90	8.69	9.49	8.83	0.0262401263134873	5.96292887027995	0.694021094676135	0.914769804504958	1:155749661-155859400:-	GON4L	9;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016604,cellular_component nuclear body;GO:0030183,biological_process B cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	gon-4 like [Source:HGNC Symbol%3BAcc:HGNC:25973]
ENSG00000166246	1.17	0.93	1.01	1.07	0.83	1.01	0.123183065565266	0.935229973356019	0.694138034425458	0.914769804504958	16:4734271-4749396:+	C16orf71	NA	NA	chromosome 16 open reading frame 71 [Source:HGNC Symbol%3BAcc:HGNC:25081]
ENSG00000148908	18.92	18.28	18.43	19.40	18.33	20.30	-0.0491605078038735	3.4679384982756	0.694169829834131	0.914769804504958	10:119499827-119542708:-	RGS10	12;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005096,molecular_function GTPase activator activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043679,cellular_component axon terminus	NA	regulator of G protein signaling 10 [Source:HGNC Symbol%3BAcc:HGNC:9992]
ENSG00000171729	72.11	66.10	65.36	73.69	63.75	72.26	-0.0300226696729015	5.71429069837347	0.694341000349429	0.914769804504958	1:15152531-15220480:+	TMEM51	6;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 51 [Source:HGNC Symbol%3BAcc:HGNC:25488]
ENSG00000173275	6.14	5.70	7.09	6.50	5.74	6.19	0.0568267133515347	3.42230980929036	0.694381615383554	0.914769804504958	X:135344795-135363152:+	ZNF449	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 449 [Source:HGNC Symbol%3BAcc:HGNC:21039]
ENSG00000205078	15.35	13.76	13.70	14.85	14.94	14.90	-0.0458390562215453	3.44781682911847	0.694414723786996	0.914769804504958	16:77199396-77213215:+	SYCE1L	5;GO:0000795,cellular_component synaptonemal complex;GO:0007130,biological_process synaptonemal complex assembly;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051321,biological_process meiotic cell cycle;GO:0070193,biological_process synaptonemal complex organization	NA	synaptonemal complex central element protein 1 like [Source:HGNC Symbol%3BAcc:HGNC:37236]
ENSG00000198933	5.97	5.28	6.10	5.60	5.88	6.67	-0.0468704072570947	3.47472958623566	0.694431682913345	0.914769804504958	17:47694080-47712050:+	TBKBP1	4;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0016032,biological_process viral process;GO:0045087,biological_process innate immune response	TBKBP1; TANK-binding kinase 1-binding protein; K12652	TBK1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30140]
ENSG00000177873	2.69	3.50	3.45	3.74	3.48	2.93	-0.0700552182045766	2.70731844485863	0.694496385689943	0.914769804504958	3:40477112-40490236:+	ZNF619	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 619 [Source:HGNC Symbol%3BAcc:HGNC:26910]
ENSG00000116688	33.74	34.42	33.12	33.56	35.33	31.30	0.027026979462532	6.25609202816977	0.69454287025959	0.914769804504958	1:11980180-12013514:+	MFN2	28;GO:0000166,molecular_function nucleotide binding;GO:0001825,biological_process blastocyst formation;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006986,biological_process response to unfolded protein;GO:0007006,biological_process mitochondrial membrane organization;GO:0007596,biological_process blood coagulation;GO:0008053,biological_process mitochondrial fusion;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0031306,cellular_component intrinsic component of mitochondrial outer membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0046580,biological_process negative regulation of Ras protein signal transduction;GO:0048593,biological_process camera-type eye morphogenesis;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0051646,biological_process mitochondrion localization;GO:0061734,biological_process parkin-mediated mitophagy in response to mitochondrial depolarization	MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]; K06030	mitofusin 2 [Source:HGNC Symbol%3BAcc:HGNC:16877]
ENSG00000204653	2.88	1.52	2.25	2.80	1.81	2.79	-0.113354287168523	1.17118000522954	0.694580139104698	0.914769804504958	19:50511599-50514690:-	ASPDH	7;GO:0006742,biological_process NADP catabolic process;GO:0009435,biological_process NAD biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0033735,molecular_function aspartate dehydrogenase activity;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process	NA	aspartate dehydrogenase domain containing [Source:HGNC Symbol%3BAcc:HGNC:33856]
ENSG00000163521	7.49	7.94	8.32	8.24	7.17	9.29	-0.0479273855558536	4.02826653443824	0.694706381126752	0.914769804504958	2:219236605-219245478:-	GLB1L	9;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004565,molecular_function beta-galactosidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005773,cellular_component vacuole;GO:0005975,biological_process carbohydrate metabolic process;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds	NA	galactosidase beta 1 like [Source:HGNC Symbol%3BAcc:HGNC:28129]
ENSG00000007968	0.75	0.95	1.52	1.54	1.04	1.02	-0.14188850281717	0.719529820676789	0.694802491976261	0.914769804504958	1:23506429-23531220:-	E2F2	21;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0008134,molecular_function transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0051726,biological_process regulation of cell cycle;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1990086,biological_process lens fiber cell apoptotic process	E2F2; transcription factor E2F2; K09389	E2F transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:3114]
ENSG00000187147	30.41	30.14	30.61	32.48	29.56	31.57	-0.0265050978621299	5.8309741555851	0.694847942586125	0.914769804504958	1:44405193-44651724:+	RNF220	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	ring finger protein 220 [Source:HGNC Symbol%3BAcc:HGNC:25552]
ENSG00000166441	1678.83	1654.83	1640.17	1706.96	1594.49	1634.13	0.0228592661881712	9.70811217252714	0.694885438288425	0.914769804504958	11:8682410-8714759:+	RPL27A	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015934,cellular_component large ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L27Ae, RPL27A; large subunit ribosomal protein L27Ae; K02900	ribosomal protein L27a [Source:HGNC Symbol%3BAcc:HGNC:10329]
ENSG00000176732	2.37	1.48	3.23	1.74	2.55	4.00	-0.187332092233335	0.219671618912604	0.694933718335578	0.914769804504958	2:24115370-24123477:-	PFN4	7;GO:0003785,molecular_function actin monomer binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005938,cellular_component cell cortex;GO:0008289,molecular_function lipid binding;GO:0015629,cellular_component actin cytoskeleton;GO:0042989,biological_process sequestering of actin monomers	PFN; profilin; K05759	profilin family member 4 [Source:HGNC Symbol%3BAcc:HGNC:31103]
ENSG00000132300	29.19	29.69	29.20	29.01	29.45	28.80	0.0245016805343396	5.98608711485167	0.694986227219555	0.914769804504958	2:86106181-86142157:+	PTCD3	15;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0006417,biological_process regulation of translation;GO:0019843,molecular_function rRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0043024,molecular_function ribosomal small subunit binding;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	pentatricopeptide repeat domain 3 [Source:HGNC Symbol%3BAcc:HGNC:24717]
ENSG00000136378	0.15	0.11	0.29	0.21	0.18	0.26	-0.181222719862918	0.250899515701673	0.695012811269335	0.914769804504958	15:78759202-78811431:-	ADAMTS7	19;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009986,cellular_component cell surface;GO:0016787,molecular_function hydrolase activity;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0036066,biological_process protein O-linked fucosylation;GO:0046872,molecular_function metal ion binding;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071773,biological_process cellular response to BMP stimulus	NA	ADAM metallopeptidase with thrombospondin type 1 motif 7 [Source:HGNC Symbol%3BAcc:HGNC:223]
ENSG00000091483	49.39	49.84	46.23	49.96	51.50	47.84	-0.0266822597580164	6.23541934649056	0.695419594343463	0.915047735157937	1:241497602-241519761:-	FH	13;GO:0003824,molecular_function catalytic activity;GO:0004333,molecular_function fumarate hydratase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006106,biological_process fumarate metabolic process;GO:0006108,biological_process malate metabolic process;GO:0016829,molecular_function lyase activity;GO:0045239,cellular_component tricarboxylic acid cycle enzyme complex;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0070062,cellular_component extracellular exosome	E4.2.1.2B, fumC, FH; fumarate hydratase, class II [EC:4.2.1.2]; K01679	fumarate hydratase [Source:HGNC Symbol%3BAcc:HGNC:3700]
ENSG00000104341	268.89	304.73	255.23	265.32	313.02	276.01	-0.0325971035630786	8.0966743907682	0.695446005952354	0.915047735157937	8:97775056-97853013:+	LAPTM4B	5;GO:0005515,molecular_function protein binding;GO:0006810,biological_process transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	LAPTM; lysosomal-associated transmembrane protein; K12387	lysosomal protein transmembrane 4 beta [Source:HGNC Symbol%3BAcc:HGNC:13646]
ENSG00000162601	9.92	9.27	9.01	8.20	9.86	9.62	0.0394267889395399	4.54297072538531	0.695475282809528	0.915047735157937	1:58654738-58700092:-	MYSM1	24;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030334,biological_process regulation of cell migration;GO:0032403,molecular_function protein complex binding;GO:0035522,biological_process monoubiquitinated histone H2A deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042393,molecular_function histone binding;GO:0043473,biological_process pigmentation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051797,biological_process regulation of hair follicle development	NA	Myb like%2C SWIRM and MPN domains 1 [Source:HGNC Symbol%3BAcc:HGNC:29401]
ENSG00000220205	12.52	12.18	10.40	11.82	13.45	7.99	0.0925179908443093	2.08646540442249	0.695518841634991	0.915047735157937	17:8159148-8163546:-	VAMP2	60;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005543,molecular_function phospholipid binding;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006887,biological_process exocytosis;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006906,biological_process vesicle fusion;GO:0007269,biological_process neurotransmitter secretion;GO:0008021,cellular_component synaptic vesicle;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0009749,biological_process response to glucose;GO:0014047,biological_process glutamate secretion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016192,biological_process vesicle-mediated transport;GO:0017075,molecular_function syntaxin-1 binding;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0017157,biological_process regulation of exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030141,cellular_component secretory granule;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0032869,biological_process cellular response to insulin stimulus;GO:0042589,cellular_component zymogen granule membrane;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043005,cellular_component neuron projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043308,biological_process eosinophil degranulation;GO:0043621,molecular_function protein self-association;GO:0044306,cellular_component neuron projection terminus;GO:0045202,cellular_component synapse;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060203,cellular_component clathrin-sculpted glutamate transport vesicle membrane;GO:0060291,biological_process long-term synaptic potentiation;GO:0060627,biological_process regulation of vesicle-mediated transport;GO:0061024,biological_process membrane organization;GO:0061025,biological_process membrane fusion;GO:0061202,cellular_component clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0070032,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0070033,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex;GO:0070044,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0070062,cellular_component extracellular exosome;GO:0070083,cellular_component clathrin-sculpted monoamine transport vesicle membrane;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:1902259,biological_process regulation of delayed rectifier potassium channel activity	VAMP2; vesicle-associated membrane protein 2; K13504	vesicle associated membrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:12643]
ENSG00000095066	15.77	14.99	16.88	16.85	14.41	15.73	0.0342308178007308	5.18213197720803	0.695599981802131	0.915057500435551	19:12763002-12872740:-	HOOK2	22;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0008017,molecular_function microtubule binding;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0030897,cellular_component HOPS complex;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045022,biological_process early endosome to late endosome transport;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0070695,cellular_component FHF complex	NA	hook microtubule tethering protein 2 [Source:HGNC Symbol%3BAcc:HGNC:19885]
ENSG00000198700	41.68	42.38	40.49	41.96	40.18	41.30	0.0239510459533492	7.0944703604174	0.695768343696288	0.915150361107224	1:201829140-201884294:+	IPO9	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0042393,molecular_function histone binding	NA	importin 9 [Source:HGNC Symbol%3BAcc:HGNC:19425]
ENSG00000204428	0.64	0.75	1.57	1.68	0.77	1.03	-0.202882018448654	0.156357593015465	0.695857888422868	0.915150361107224	6:31676683-31684040:-	LY6G5C	7;GO:0005576,cellular_component extracellular region;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0051260,biological_process protein homooligomerization	NA	lymphocyte antigen 6 family member G5C [Source:HGNC Symbol%3BAcc:HGNC:13932]
ENSG00000145147	1.50	2.05	1.55	1.84	1.99	1.52	-0.0694286867459083	3.09308160252187	0.695891747240078	0.915150361107224	4:20253259-20620561:+	SLIT2	55;GO:0001657,biological_process ureteric bud development;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0002689,biological_process negative regulation of leukocyte chemotaxis;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006935,biological_process chemotaxis;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0008045,biological_process motor neuron axon guidance;GO:0008201,molecular_function heparin binding;GO:0010593,biological_process negative regulation of lamellipodium assembly;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0021836,biological_process chemorepulsion involved in postnatal olfactory bulb interneuron migration;GO:0021972,biological_process corticospinal neuron axon guidance through spinal cord;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0030336,biological_process negative regulation of cell migration;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0032870,biological_process cellular response to hormone stimulus;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035385,biological_process Roundabout signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043116,biological_process negative regulation of vascular permeability;GO:0043237,molecular_function laminin-1 binding;GO:0043394,molecular_function proteoglycan binding;GO:0048495,molecular_function Roundabout binding;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048846,biological_process axon extension involved in axon guidance;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050919,biological_process negative chemotaxis;GO:0050929,biological_process induction of negative chemotaxis;GO:0051058,biological_process negative regulation of small GTPase mediated signal transduction;GO:0051414,biological_process response to cortisol;GO:0061364,biological_process apoptotic process involved in luteolysis;GO:0070062,cellular_component extracellular exosome;GO:0070100,biological_process negative regulation of chemokine-mediated signaling pathway;GO:0071504,biological_process cellular response to heparin;GO:0071672,biological_process negative regulation of smooth muscle cell chemotaxis;GO:0071676,biological_process negative regulation of mononuclear cell migration;GO:0090024,biological_process negative regulation of neutrophil chemotaxis;GO:0090027,biological_process negative regulation of monocyte chemotaxis;GO:0090260,biological_process negative regulation of retinal ganglion cell axon guidance;GO:0090288,biological_process negative regulation of cellular response to growth factor stimulus	SLIT2; slit 2; K06839	slit guidance ligand 2 [Source:HGNC Symbol%3BAcc:HGNC:11086]
ENSG00000151929	16.85	17.22	16.63	16.39	18.27	15.23	0.034871558409498	4.86602120794479	0.696048284089674	0.915182065375074	10:119651369-119677819:+	BAG3	27;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0006915,biological_process apoptotic process;GO:0007420,biological_process brain development;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0010664,biological_process negative regulation of striated muscle cell apoptotic process;GO:0021510,biological_process spinal cord development;GO:0030018,cellular_component Z disc;GO:0032403,molecular_function protein complex binding;GO:0034605,biological_process cellular response to heat;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043005,cellular_component neuron projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045296,molecular_function cadherin binding;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0050790,biological_process regulation of catalytic activity;GO:0050821,biological_process protein stabilization;GO:0051087,molecular_function chaperone binding;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097201,biological_process negative regulation of transcription from RNA polymerase II promoter in response to stress;GO:1900034,biological_process regulation of cellular response to heat	NA	BCL2 associated athanogene 3 [Source:HGNC Symbol%3BAcc:HGNC:939]
ENSG00000170791	58.39	62.21	54.29	58.56	55.00	58.13	0.03272378014941	4.55246711966706	0.696123230310269	0.915182065375074	8:56211685-56218798:+	CHCHD7	2;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space	NA	coiled-coil-helix-coiled-coil-helix domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:28314]
ENSG00000163900	10.21	10.19	11.18	11.47	9.20	12.50	-0.0594328815000301	3.16762004700345	0.696137038691005	0.915182065375074	3:185476495-185499057:-	TMEM41A	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 41A [Source:HGNC Symbol%3BAcc:HGNC:30544]
ENSG00000132600	10.50	9.37	10.30	10.30	11.06	9.90	-0.0335916288367329	4.48848953432998	0.696662231007815	0.915775524038972	16:68310973-68358563:+	PRMT7	35;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0001650,cellular_component fibrillar center;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0008469,molecular_function histone-arginine N-methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016277,molecular_function [myelin basic protein]-arginine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018216,biological_process peptidyl-arginine methylation;GO:0019918,biological_process peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0019919,biological_process peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0030154,biological_process cell differentiation;GO:0032259,biological_process methylation;GO:0034969,biological_process histone arginine methylation;GO:0035241,molecular_function protein-arginine omega-N monomethyltransferase activity;GO:0035242,molecular_function protein-arginine omega-N asymmetric methyltransferase activity;GO:0035243,molecular_function protein-arginine omega-N symmetric methyltransferase activity;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0035247,biological_process peptidyl-arginine omega-N-methylation;GO:0042393,molecular_function histone binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043046,biological_process DNA methylation involved in gamete generation;GO:0043393,biological_process regulation of protein binding;GO:0043985,biological_process histone H4-R3 methylation;GO:0044020,molecular_function histone methyltransferase activity (H4-R3 specific)	NA	protein arginine methyltransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:25557]
ENSG00000168781	3.01	3.17	3.46	3.61	3.59	2.83	-0.0446112455240538	3.94264094806949	0.696736104156949	0.915775652361309	15:43533461-43590253:-	PPIP5K1	22;GO:0000166,molecular_function nucleotide binding;GO:0000827,molecular_function inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828,molecular_function inositol hexakisphosphate kinase activity;GO:0000829,molecular_function inositol heptakisphosphate kinase activity;GO:0000832,molecular_function inositol hexakisphosphate 5-kinase activity;GO:0003993,molecular_function acid phosphatase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006020,biological_process inositol metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016740,molecular_function transferase activity;GO:0032958,biological_process inositol phosphate biosynthetic process;GO:0033857,molecular_function diphosphoinositol-pentakisphosphate kinase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0052723,molecular_function inositol hexakisphosphate 1-kinase activity;GO:0052724,molecular_function inositol hexakisphosphate 3-kinase activity	PPIP5K, VIP; inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase [EC:2.7.4.24]; K13024	diphosphoinositol pentakisphosphate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:29023]
ENSG00000197226	43.33	43.21	44.54	43.44	44.36	42.20	0.0240065235763052	7.37324208955227	0.696875985517555	0.915794672532186	5:179862065-179907859:-	TBC1D9B	11;GO:0005096,molecular_function GTPase activator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 9B [Source:HGNC Symbol%3BAcc:HGNC:29097]
ENSG00000089693	226.26	234.11	208.00	225.10	229.19	231.34	-0.0259767898219558	7.45399500824054	0.696898129117782	0.915794672532186	12:6747995-6767475:-	MLF2	5;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006952,biological_process defense response;GO:0016020,cellular_component membrane	NA	myeloid leukemia factor 2 [Source:HGNC Symbol%3BAcc:HGNC:7126]
ENSG00000188747	7.85	8.05	10.36	9.46	6.96	9.03	0.0592444416837763	3.66331570508259	0.697121918639117	0.915939786917969	9:137423349-137434406:+	NOXA1	14;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006801,biological_process superoxide metabolic process;GO:0010310,biological_process regulation of hydrogen peroxide metabolic process;GO:0016020,cellular_component membrane;GO:0016176,molecular_function superoxide-generating NADPH oxidase activator activity;GO:0017124,molecular_function SH3 domain binding;GO:0019899,molecular_function enzyme binding;GO:0043020,cellular_component NADPH oxidase complex;GO:0043085,biological_process positive regulation of catalytic activity;GO:0048365,molecular_function Rac GTPase binding;GO:0060263,biological_process regulation of respiratory burst	NA	NADPH oxidase activator 1 [Source:HGNC Symbol%3BAcc:HGNC:10668]
ENSG00000198826	25.08	28.37	23.16	25.26	28.31	25.34	-0.0335090180889491	6.32496570770976	0.697183665153316	0.915939786917969	15:32615143-32639949:+	ARHGAP11A	5;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 11A [Source:HGNC Symbol%3BAcc:HGNC:15783]
ENSG00000188321	3.82	3.94	3.76	3.59	3.73	3.87	0.0497701019784447	3.11764284556992	0.697282848535207	0.915939786917969	19:9323771-9351162:+	ZNF559	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 559 [Source:HGNC Symbol%3BAcc:HGNC:28197]
ENSG00000187446	44.94	44.70	47.08	45.29	47.39	48.23	-0.03098198110221	4.81663684889384	0.697356979357404	0.915939786917969	15:41230838-41281890:+	CHP1	52;GO:0000139,cellular_component Golgi membrane;GO:0001578,biological_process microtubule bundle formation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005215,molecular_function transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006813,biological_process potassium ion transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008017,molecular_function microtubule binding;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0015459,molecular_function potassium channel regulator activity;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0019900,molecular_function kinase binding;GO:0022406,biological_process membrane docking;GO:0030133,cellular_component transport vesicle;GO:0030214,biological_process hyaluronan catabolic process;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031953,biological_process negative regulation of protein autophosphorylation;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032417,biological_process positive regulation of sodium:proton antiporter activity;GO:0042308,biological_process negative regulation of protein import into nucleus;GO:0046872,molecular_function metal ion binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0050821,biological_process protein stabilization;GO:0051222,biological_process positive regulation of protein transport;GO:0051259,biological_process protein oligomerization;GO:0051453,biological_process regulation of intracellular pH;GO:0060050,biological_process positive regulation of protein glycosylation;GO:0061024,biological_process membrane organization;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome;GO:0070885,biological_process negative regulation of calcineurin-NFAT signaling cascade;GO:0071468,biological_process cellular response to acidic pH;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1901214,biological_process regulation of neuron death	PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit; K06268	calcineurin like EF-hand protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17433]
ENSG00000169223	204.89	208.12	209.54	210.27	221.27	206.51	-0.0237390504764213	7.84245006923767	0.697377501503402	0.915939786917969	5:177331561-177351852:-	LMAN2	20;GO:0000139,cellular_component Golgi membrane;GO:0005537,molecular_function mannose binding;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0009986,cellular_component cell surface;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0031072,molecular_function heat shock protein binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0046872,molecular_function metal ion binding;GO:0050766,biological_process positive regulation of phagocytosis;GO:0070062,cellular_component extracellular exosome	LMAN2, VIP36; lectin, mannose-binding 2; K10082	lectin%2C mannose binding 2 [Source:HGNC Symbol%3BAcc:HGNC:16986]
ENSG00000089009	1083.83	1067.37	1031.78	1098.82	1005.53	1052.74	0.0234824823378754	9.8356633399299	0.697746649536386	0.916327672523822	12:112405189-112418838:-	RPL6	22;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0045296,molecular_function cadherin binding	RP-L6e, RPL6; large subunit ribosomal protein L6e; K02934	ribosomal protein L6 [Source:HGNC Symbol%3BAcc:HGNC:10362]
ENSG00000087302	162.00	154.58	151.32	166.31	147.02	167.44	-0.0273690468154852	6.85782701610338	0.697832696083694	0.916343727545425	14:51989474-52010691:+	C14orf166	18;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0016032,biological_process viral process;GO:0042802,molecular_function identical protein binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050658,biological_process RNA transport;GO:0072669,cellular_component tRNA-splicing ligase complex	NA	chromosome 14 open reading frame 166 [Source:HGNC Symbol%3BAcc:HGNC:23169]
ENSG00000111752	17.26	15.87	17.77	17.91	16.24	18.26	-0.0277560685913843	5.7341785136237	0.698038648363042	0.916517214103072	12:8913895-8941467:+	PHC1	10;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0016574,biological_process histone ubiquitination;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex;GO:0046872,molecular_function metal ion binding	NA	polyhomeotic homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:3182]
ENSG00000049618	12.99	13.56	13.19	13.95	13.49	13.31	-0.0253394741698972	6.69683701527198	0.698216611754123	0.916653918741822	6:156777373-157210779:+	ARID1B	19;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007270,biological_process neuron-neuron synaptic transmission;GO:0007399,biological_process nervous system development;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0060996,biological_process dendritic spine development;GO:0071565,cellular_component nBAF complex;GO:0090544,cellular_component BAF-type complex;GO:0097026,biological_process dendritic cell dendrite assembly	ARID1; AT-rich interactive domain-containing protein 1; K11653	AT-rich interaction domain 1B [Source:HGNC Symbol%3BAcc:HGNC:18040]
ENSG00000135317	55.96	56.28	56.72	54.83	56.19	56.62	0.0230738382823463	7.34579203664943	0.698502463950908	0.916913236460479	6:85505495-85594156:-	SNX14	14;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0031902,cellular_component late endosome membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042995,cellular_component cell projection;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:0097352,biological_process autophagosome maturation	NA	sorting nexin 14 [Source:HGNC Symbol%3BAcc:HGNC:14977]
ENSG00000102078	10.44	9.48	8.61	8.89	9.01	9.87	0.0501694486833729	3.34959923455504	0.698578309334265	0.916913236460479	X:130339887-130373361:+	SLC25A14	13;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0009060,biological_process aerobic respiration;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0031966,cellular_component mitochondrial membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 14 [Source:HGNC Symbol%3BAcc:HGNC:10984]
ENSG00000184602	12.31	12.67	13.38	13.33	15.23	12.52	-0.0839551853656937	1.8672722609044	0.698635735957723	0.916913236460479	16:11668413-11679159:+	SNN	7;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0009636,biological_process response to toxic substance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	stannin [Source:HGNC Symbol%3BAcc:HGNC:11149]
ENSG00000118939	13.85	15.06	11.85	12.31	12.12	14.99	0.0504420343129051	3.57491688729679	0.698924709226127	0.917119514120637	13:75549479-75606020:+	UCHL3	19;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019784,molecular_function NEDD8-specific protease activity;GO:0030163,biological_process protein catabolic process;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043130,molecular_function ubiquitin binding;GO:0043687,biological_process post-translational protein modification;GO:0070062,cellular_component extracellular exosome	NA	ubiquitin C-terminal hydrolase L3 [Source:HGNC Symbol%3BAcc:HGNC:12515]
ENSG00000157601	1.79	1.38	1.69	1.86	1.55	1.82	-0.0803482866363238	1.83038968649659	0.698940675387193	0.917119514120637	21:41420303-41459214:+	MX1	28;GO:0000166,molecular_function nucleotide binding;GO:0000266,biological_process mitochondrial fission;GO:0002376,biological_process immune system process;GO:0003374,biological_process dynamin polymerization involved in mitochondrial fission;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006952,biological_process defense response;GO:0007165,biological_process signal transduction;GO:0008017,molecular_function microtubule binding;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0031965,cellular_component nuclear membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0034340,biological_process response to type I interferon;GO:0042802,molecular_function identical protein binding;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0061025,biological_process membrane fusion	MX1; interferon-induced GTP-binding protein Mx1; K14754	MX dynamin like GTPase 1 [Source:HGNC Symbol%3BAcc:HGNC:7532]
ENSG00000144366	28.70	29.23	31.31	29.61	27.84	30.73	0.0289376196178996	5.35006152219035	0.69914964553644	0.917195047413124	2:188291668-188595931:+	GULP1	8;GO:0004871,molecular_function signal transducer activity;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006909,biological_process phagocytosis;GO:0006911,biological_process phagocytosis, engulfment;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction	NA	GULP%2C engulfment adaptor PTB domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18649]
ENSG00000197748	0.88	0.91	0.91	1.01	0.87	0.98	-0.0746206266213225	2.27074555832139	0.69928612553534	0.917195047413124	10:104129887-104232362:-	CFAP43	1;GO:0042995,cellular_component cell projection	NA	cilia and flagella associated protein 43 [Source:HGNC Symbol%3BAcc:HGNC:26684]
ENSG00000125629	62.53	62.55	60.32	63.67	59.19	60.48	0.0271283050530689	5.46296626407409	0.699292446411018	0.917195047413124	2:118088451-118110997:+	INSIG2	24;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006991,biological_process response to sterol depletion;GO:0008134,molecular_function transcription factor binding;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0010894,biological_process negative regulation of steroid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0032868,biological_process response to insulin;GO:0032933,biological_process SREBP signaling pathway;GO:0032937,cellular_component SREBP-SCAP-Insig complex;GO:0033993,biological_process response to lipid;GO:0042472,biological_process inner ear morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0060021,biological_process palate development;GO:0060363,biological_process cranial suture morphogenesis;GO:0070542,biological_process response to fatty acid	NA	insulin induced gene 2 [Source:HGNC Symbol%3BAcc:HGNC:20452]
ENSG00000116478	145.35	152.67	138.35	148.92	150.16	148.22	-0.0247610217945022	7.73612386009367	0.699293799139435	0.917195047413124	1:32292085-32333635:+	HDAC1	71;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0002039,molecular_function p53 binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0006338,biological_process chromatin remodeling;GO:0006346,biological_process methylation-dependent chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006476,biological_process protein deacetylation;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009913,biological_process epidermal cell differentiation;GO:0010629,biological_process negative regulation of gene expression;GO:0010870,biological_process positive regulation of receptor biosynthetic process;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016580,cellular_component Sin3 complex;GO:0016581,cellular_component NuRD complex;GO:0016787,molecular_function hydrolase activity;GO:0019213,molecular_function deacetylase activity;GO:0019899,molecular_function enzyme binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0032922,biological_process circadian regulation of gene expression;GO:0033558,molecular_function protein deacetylase activity;GO:0033613,molecular_function activating transcription factor binding;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042826,molecular_function histone deacetylase binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0048511,biological_process rhythmic process;GO:0051059,molecular_function NF-kappaB binding;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0060789,biological_process hair follicle placode formation;GO:0061029,biological_process eyelid development in camera-type eye;GO:0061198,biological_process fungiform papilla formation;GO:0070491,molecular_function repressing transcription factor binding;GO:0070932,biological_process histone H3 deacetylation;GO:0070933,biological_process histone H4 deacetylation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904837,biological_process beta-catenin-TCF complex assembly	HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]; K06067	histone deacetylase 1 [Source:HGNC Symbol%3BAcc:HGNC:4852]
ENSG00000115257	4.46	2.95	4.16	3.34	3.92	3.94	0.0746494241893536	3.14085522330361	0.699426357667334	0.91723286220094	19:1481427-1490752:-	PCSK4	17;GO:0001669,cellular_component acrosomal vesicle;GO:0002080,cellular_component acrosomal membrane;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0006508,biological_process proteolysis;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0007340,biological_process acrosome reaction;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009566,biological_process fertilization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0022414,biological_process reproductive process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048240,biological_process sperm capacitation	NA	proprotein convertase subtilisin/kexin type 4 [Source:HGNC Symbol%3BAcc:HGNC:8746]
ENSG00000131480	0.59	0.88	0.62	0.86	0.54	0.90	-0.152515329204524	0.847468906597162	0.699491850773932	0.91723286220094	17:42844599-42850707:+	AOC2	18;GO:0005507,molecular_function copper ion binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006584,biological_process catecholamine metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0007601,biological_process visual perception;GO:0008131,molecular_function primary amine oxidase activity;GO:0009055,molecular_function electron carrier activity;GO:0009308,biological_process amine metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0048038,molecular_function quinone binding;GO:0052593,molecular_function tryptamine:oxygen oxidoreductase (deaminating) activity;GO:0052594,molecular_function aminoacetone:oxygen oxidoreductase(deaminating) activity;GO:0052595,molecular_function aliphatic-amine oxidase activity;GO:0052596,molecular_function phenethylamine:oxygen oxidoreductase (deaminating) activity;GO:0055114,biological_process oxidation-reduction process	AOC3, AOC2, tynA; primary-amine oxidase [EC:1.4.3.21]; K00276	amine oxidase%2C copper containing 2 [Source:HGNC Symbol%3BAcc:HGNC:549]
ENSG00000253250	65.80	60.17	62.28	65.27	58.77	61.50	0.036174060820889	4.46283964847759	0.699544308906493	0.91723286220094	8:90958636-90985257:-	C8orf88	3;GO:0005737,cellular_component cytoplasm;GO:0008190,molecular_function eukaryotic initiation factor 4E binding;GO:0045947,biological_process negative regulation of translational initiation	NA	chromosome 8 open reading frame 88 [Source:HGNC Symbol%3BAcc:HGNC:44672]
ENSG00000119979	28.42	27.66	28.79	30.48	24.93	28.17	0.0348833410104624	4.9189252234307	0.699764867477321	0.917392260829164	10:119104085-119137984:+	FAM45A	NA	NA	family with sequence similarity 45 member A [Source:HGNC Symbol%3BAcc:HGNC:31793]
ENSG00000254726	1.00	1.41	0.94	1.25	1.75	0.68	-0.134109194710616	0.965521620112189	0.699813688696637	0.917392260829164	1:156072012-156081998:-	MEX3A	7;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0046872,molecular_function metal ion binding	NA	mex-3 RNA binding family member A [Source:HGNC Symbol%3BAcc:HGNC:33482]
ENSG00000005189	4.38	3.83	3.87	4.39	4.12	4.12	-0.0456378816652028	3.28305838226609	0.700159250477533	0.917520678370215	16:20806428-20849668:+	REXO5	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005730,cellular_component nucleolus;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	REX1, REXO1, RNH70; RNA exonuclease 1 [EC:3.1.-.-]; K14570	RNA exonuclease 5 [Source:HGNC Symbol%3BAcc:HGNC:24661]
ENSG00000168924	11.95	13.36	12.38	12.77	13.48	12.56	-0.0348545263488731	4.82750601693857	0.700194820344959	0.917520678370215	4:1811478-1856247:-	LETM1	20;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0006875,biological_process cellular metal ion homeostasis;GO:0015297,molecular_function antiporter activity;GO:0015369,molecular_function calcium:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034214,biological_process protein hexamerization;GO:0042407,biological_process cristae formation;GO:0043022,molecular_function ribosome binding;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0099093,biological_process mitochondrial calcium release	NA	leucine zipper and EF-hand containing transmembrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6556]
ENSG00000160789	193.01	185.26	187.42	188.49	184.93	188.35	0.021954160024811	8.80456551779227	0.700196011412891	0.917520678370215	1:156082572-156140089:+	LMNA	30;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005638,cellular_component lamin filament;GO:0005652,cellular_component nuclear lamina;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0006997,biological_process nucleus organization;GO:0006998,biological_process nuclear envelope organization;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016607,cellular_component nuclear speck;GO:0030334,biological_process regulation of cell migration;GO:0030951,biological_process establishment or maintenance of microtubule cytoskeleton polarity;GO:0031012,cellular_component extracellular matrix;GO:0031965,cellular_component nuclear membrane;GO:0034504,biological_process protein localization to nucleus;GO:0035105,biological_process sterol regulatory element binding protein import into nucleus;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0055015,biological_process ventricular cardiac muscle cell development;GO:0071456,biological_process cellular response to hypoxia;GO:0072201,biological_process negative regulation of mesenchymal cell proliferation;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0090343,biological_process positive regulation of cell aging;GO:1900180,biological_process regulation of protein localization to nucleus;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	LMNA; lamin A/C; K12641	lamin A/C [Source:HGNC Symbol%3BAcc:HGNC:6636]
ENSG00000178297	1.76	1.50	2.20	1.79	1.62	1.84	0.0803301489992158	2.55059493773632	0.700207313800133	0.917520678370215	19:2389770-2426239:+	TMPRSS9	9;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity	NA	transmembrane protease%2C serine 9 [Source:HGNC Symbol%3BAcc:HGNC:30079]
ENSG00000026103	11.70	12.28	12.86	13.96	13.52	10.95	-0.0475853698877729	3.80814172877661	0.700463741335682	0.917658100808327	10:88990581-89015785:+	FAS	76;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002377,biological_process immunoglobulin production;GO:0003014,biological_process renal system process;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005576,cellular_component extracellular region;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006924,biological_process activation-induced cell death of T cells;GO:0006925,biological_process inflammatory cell apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007623,biological_process circadian rhythm;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0009636,biological_process response to toxic substance;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010467,biological_process gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016604,cellular_component nuclear body;GO:0019724,biological_process B cell mediated immunity;GO:0019900,molecular_function kinase binding;GO:0031264,cellular_component death-inducing signaling complex;GO:0031265,cellular_component CD95 death-inducing signaling complex;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0032496,biological_process response to lipopolysaccharide;GO:0032872,biological_process regulation of stress-activated MAPK cascade;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034198,biological_process cellular response to amino acid starvation;GO:0036337,biological_process Fas signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043029,biological_process T cell homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043120,molecular_function tumor necrosis factor binding;GO:0045060,biological_process negative thymic T cell selection;GO:0045121,cellular_component membrane raft;GO:0045619,biological_process regulation of lymphocyte differentiation;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0048536,biological_process spleen development;GO:0050869,biological_process negative regulation of B cell activation;GO:0051260,biological_process protein homooligomerization;GO:0051384,biological_process response to glucocorticoid;GO:0051402,biological_process neuron apoptotic process;GO:0070062,cellular_component extracellular exosome;GO:0070230,biological_process positive regulation of lymphocyte apoptotic process;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071285,biological_process cellular response to lithium ion;GO:0071455,biological_process cellular response to hyperoxia;GO:0097049,biological_process motor neuron apoptotic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097284,biological_process hepatocyte apoptotic process;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097527,biological_process necroptotic signaling pathway;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001235,biological_process positive regulation of apoptotic signaling pathway;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway;GO:2001241,biological_process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001269,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6; K04390	Fas cell surface death receptor [Source:HGNC Symbol%3BAcc:HGNC:11920]
ENSG00000182154	56.54	47.67	52.65	52.28	52.78	57.66	-0.03507841663674	4.46704588994265	0.700626914325656	0.917658100808327	9:137551198-137552555:+	MRPL41	13;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L41 [Source:HGNC Symbol%3BAcc:HGNC:14492]
ENSG00000102699	34.26	34.65	34.07	32.57	35.34	34.21	0.0236328084587332	7.46796678316376	0.700633103855483	0.917658100808327	13:24420925-24512810:-	PARP4	24;GO:0003677,molecular_function DNA binding;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0006281,biological_process DNA repair;GO:0006464,biological_process cellular protein modification process;GO:0006471,biological_process protein ADP-ribosylation;GO:0006810,biological_process transport;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008219,biological_process cell death;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019899,molecular_function enzyme binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042493,biological_process response to drug;GO:0051972,biological_process regulation of telomerase activity;GO:0070062,cellular_component extracellular exosome	PARP; poly [ADP-ribose] polymerase [EC:2.4.2.30]; K10798	poly(ADP-ribose) polymerase family member 4 [Source:HGNC Symbol%3BAcc:HGNC:271]
ENSG00000067900	20.39	19.45	20.66	20.21	19.33	20.44	0.0254111382471854	6.37152243128017	0.700640677142189	0.917658100808327	18:20946905-21111851:-	ROCK1	63;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0003383,biological_process apical constriction;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006939,biological_process smooth muscle contraction;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007266,biological_process Rho protein signal transduction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016740,molecular_function transferase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0017049,molecular_function GTP-Rho binding;GO:0022614,biological_process membrane to membrane docking;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030155,biological_process regulation of cell adhesion;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0032059,cellular_component bleb;GO:0032060,biological_process bleb assembly;GO:0032091,biological_process negative regulation of protein binding;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0032970,biological_process regulation of actin filament-based process;GO:0034774,cellular_component secretory granule lumen;GO:0035509,biological_process negative regulation of myosin-light-chain-phosphatase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042995,cellular_component cell projection;GO:0043312,biological_process neutrophil degranulation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0050901,biological_process leukocyte tethering or rolling;GO:0051451,biological_process myoblast migration;GO:0051492,biological_process regulation of stress fiber assembly;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0097194,biological_process execution phase of apoptosis;GO:1903140,biological_process regulation of establishment of endothelial barrier;GO:1903347,biological_process negative regulation of bicellular tight junction assembly;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000145,biological_process regulation of cell motility	ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.1]; K04514	Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:10251]
ENSG00000111554	6.61	6.40	4.93	5.81	5.70	5.98	0.0445489725824661	3.86694920215065	0.700729418971735	0.917658100808327	12:68272442-68332381:-	MDM1	11;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0046600,biological_process negative regulation of centriole replication;GO:0060041,biological_process retina development in camera-type eye	NA	Mdm1 nuclear protein [Source:HGNC Symbol%3BAcc:HGNC:29917]
ENSG00000110675	1.69	3.15	1.69	1.64	2.12	2.18	0.105998556664222	1.13386821209483	0.700784974819936	0.917658100808327	11:107591090-107666779:+	ELMOD1	6;GO:0005096,molecular_function GTPase activator activity;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0031647,biological_process regulation of protein stability;GO:0043547,biological_process positive regulation of GTPase activity;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	ELMO domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25334]
ENSG00000125089	1.48	1.50	1.61	1.59	1.47	1.77	-0.0605832915154942	2.80238202858935	0.700829678213401	0.917658100808327	4:8182071-8241803:+	SH3TC1	2;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	SH3 domain and tetratricopeptide repeats 1 [Source:HGNC Symbol%3BAcc:HGNC:26009]
ENSG00000119328	17.35	20.27	19.37	17.79	16.69	20.86	0.0451653334636219	3.57005061844549	0.700914019242369	0.917671735139281	9:108934180-108950744:+	FAM206A	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016607,cellular_component nuclear speck;GO:0030425,cellular_component dendrite	NA	family with sequence similarity 206 member A [Source:HGNC Symbol%3BAcc:HGNC:1364]
ENSG00000137700	35.70	37.29	37.64	36.36	38.68	34.35	0.0280384322429491	5.63730444730116	0.701393501756941	0.918090906126188	11:119024113-119030906:-	SLC37A4	26;GO:0001780,biological_process neutrophil homeostasis;GO:0001816,biological_process cytokine production;GO:0002318,biological_process myeloid progenitor cell differentiation;GO:0005215,molecular_function transporter activity;GO:0005977,biological_process glycogen metabolic process;GO:0006089,biological_process lactate metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006810,biological_process transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007584,biological_process response to nutrient;GO:0008202,biological_process steroid metabolic process;GO:0009749,biological_process response to glucose;GO:0014070,biological_process response to organic cyclic compound;GO:0015152,molecular_function glucose-6-phosphate transmembrane transporter activity;GO:0015760,biological_process glucose-6-phosphate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030593,biological_process neutrophil chemotaxis;GO:0032682,biological_process negative regulation of chemokine production;GO:0035166,biological_process post-embryonic hemopoiesis;GO:0042593,biological_process glucose homeostasis;GO:0042632,biological_process cholesterol homeostasis;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045730,biological_process respiratory burst;GO:0055085,biological_process transmembrane transport	SLC37A4; MFS transporter, OPA family, solute carrier family 37 (glycerol-6-phosphate transporter), member 4; K08171	solute carrier family 37 member 4 [Source:HGNC Symbol%3BAcc:HGNC:4061]
ENSG00000103042	7.34	7.17	7.65	6.45	7.42	7.78	0.0463923591565974	3.58993049379591	0.701398395866936	0.918090906126188	16:58665108-58685104:-	SLC38A7	30;GO:0005290,molecular_function L-histidine transmembrane transporter activity;GO:0005313,molecular_function L-glutamate transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006865,biological_process amino acid transport;GO:0006867,biological_process asparagine transport;GO:0006868,biological_process glutamine transport;GO:0015179,molecular_function L-amino acid transmembrane transporter activity;GO:0015180,molecular_function L-alanine transmembrane transporter activity;GO:0015182,molecular_function L-asparagine transmembrane transporter activity;GO:0015183,molecular_function L-aspartate transmembrane transporter activity;GO:0015186,molecular_function L-glutamine transmembrane transporter activity;GO:0015190,molecular_function L-leucine transmembrane transporter activity;GO:0015191,molecular_function L-methionine transmembrane transporter activity;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015803,biological_process branched-chain amino acid transport;GO:0015808,biological_process L-alanine transport;GO:0015821,biological_process methionine transport;GO:0015825,biological_process L-serine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030424,cellular_component axon;GO:0043025,cellular_component neuronal cell body;GO:0089709,biological_process L-histidine transmembrane transport;GO:0089711,biological_process L-glutamate transmembrane transport;GO:0089712,biological_process L-aspartate transmembrane transport;GO:0098655,biological_process cation transmembrane transport;GO:1902475,biological_process L-alpha-amino acid transmembrane transport	NA	solute carrier family 38 member 7 [Source:HGNC Symbol%3BAcc:HGNC:25582]
ENSG00000133424	10.11	10.42	10.38	10.08	11.70	10.16	-0.0351824621839035	4.6287879328303	0.701467676808775	0.918090906126188	22:33162225-33922841:-	LARGE1	25;GO:0000139,cellular_component Golgi membrane;GO:0003824,molecular_function catalytic activity;GO:0005794,cellular_component Golgi apparatus;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0006688,biological_process glycosphingolipid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0009101,biological_process glycoprotein biosynthetic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030145,molecular_function manganese ion binding;GO:0030173,cellular_component integral component of Golgi membrane;GO:0035252,molecular_function UDP-xylosyltransferase activity;GO:0035269,biological_process protein O-linked mannosylation;GO:0042285,molecular_function xylosyltransferase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046872,molecular_function metal ion binding;GO:0060538,biological_process skeletal muscle organ development	LARGE; glycosyltransferase-like protein LARGE [EC:2.4.2.- 2.4.1.-]; K09668	LARGE xylosyl- and glucuronyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:6511]
ENSG00000101474	129.15	122.69	132.10	127.08	131.83	121.67	0.0253477820244325	7.34313291894089	0.701559966085969	0.918090906126188	20:24962924-24992979:-	APMAP	9;GO:0004064,molecular_function arylesterase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0008150,biological_process biological_process;GO:0009058,biological_process biosynthetic process;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016844,molecular_function strictosidine synthase activity;GO:0070062,cellular_component extracellular exosome	NA	adipocyte plasma membrane associated protein [Source:HGNC Symbol%3BAcc:HGNC:13238]
ENSG00000152422	6.38	7.58	6.43	7.72	7.60	6.07	-0.0653791029471499	2.83615720739185	0.701695636210342	0.918090906126188	5:83077497-83353787:+	XRCC4	20;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005958,cellular_component DNA-dependent protein kinase-DNA ligase 4 complex;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008022,molecular_function protein C-terminus binding;GO:0010165,biological_process response to X-ray;GO:0032807,cellular_component DNA ligase IV complex;GO:0042802,molecular_function identical protein binding;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0051351,biological_process positive regulation of ligase activity;GO:0070419,cellular_component nonhomologous end joining complex;GO:0071285,biological_process cellular response to lithium ion;GO:0075713,biological_process establishment of integrated proviral latency	XRCC4; DNA-repair protein XRCC4; K10886	X-ray repair cross complementing 4 [Source:HGNC Symbol%3BAcc:HGNC:12831]
ENSG00000104299	4.85	5.34	4.29	4.62	5.73	4.76	-0.0558629788278922	3.34824365161259	0.701720216814876	0.918090906126188	8:28767660-28890242:-	INTS9	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0016180,biological_process snRNA processing;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 9 [Source:HGNC Symbol%3BAcc:HGNC:25592]
ENSG00000188070	6.28	5.16	5.24	5.19	6.00	6.29	-0.0489560811759912	3.55916357885863	0.701751914712421	0.918090906126188	11:63759891-63768775:-	C11orf95	1;GO:0003676,molecular_function nucleic acid binding	NA	chromosome 11 open reading frame 95 [Source:HGNC Symbol%3BAcc:HGNC:28449]
ENSG00000113448	0.38	0.32	0.33	0.21	0.30	0.42	0.16674915832941	0.397297957228792	0.701864615158297	0.91809751095853	5:58969037-60522120:-	PDE4D	51;GO:0002027,biological_process regulation of heart rate;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005891,cellular_component voltage-gated calcium channel complex;GO:0006198,biological_process cAMP catabolic process;GO:0006939,biological_process smooth muscle contraction;GO:0007165,biological_process signal transduction;GO:0007568,biological_process aging;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008144,molecular_function drug binding;GO:0010469,biological_process regulation of receptor activity;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0019933,biological_process cAMP-mediated signaling;GO:0030552,molecular_function cAMP binding;GO:0030593,biological_process neutrophil chemotaxis;GO:0030814,biological_process regulation of cAMP metabolic process;GO:0031698,molecular_function beta-2 adrenergic receptor binding;GO:0031965,cellular_component nuclear membrane;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0032754,biological_process positive regulation of interleukin-5 production;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034704,cellular_component calcium channel complex;GO:0035264,biological_process multicellular organism growth;GO:0044325,molecular_function ion channel binding;GO:0045822,biological_process negative regulation of heart contraction;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0051117,molecular_function ATPase binding;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0061028,biological_process establishment of endothelial barrier;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071872,biological_process cellular response to epinephrine stimulus;GO:0071875,biological_process adrenergic receptor signaling pathway;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:0086024,biological_process adrenergic receptor signaling pathway involved in positive regulation of heart rate;GO:0097110,molecular_function scaffold protein binding;GO:1901844,biological_process regulation of cell communication by electrical coupling involved in cardiac conduction;GO:1901898,biological_process negative regulation of relaxation of cardiac muscle	cpdP; 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]; K01120	phosphodiesterase 4D [Source:HGNC Symbol%3BAcc:HGNC:8783]
ENSG00000126453	19.88	20.79	18.81	20.31	20.58	17.45	0.0380639186491572	4.41486068498031	0.70190488834258	0.91809751095853	19:49665141-49673916:+	BCL2L12	9;GO:0002039,molecular_function p53 binding;GO:0005634,cellular_component nucleus;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0042981,biological_process regulation of apoptotic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1990001,biological_process inhibition of cysteine-type endopeptidase activity involved in apoptotic process;GO:2000773,biological_process negative regulation of cellular senescence	NA	BCL2 like 12 [Source:HGNC Symbol%3BAcc:HGNC:13787]
ENSG00000141646	29.39	26.32	27.21	29.22	26.78	25.99	0.0311767218755581	5.55175133353721	0.702205700859255	0.918394201323984	18:51028393-51085045:+	SMAD4	116;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0000988,molecular_function transcription factor activity, protein binding;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001541,biological_process ovarian follicle development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001822,biological_process kidney development;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003190,biological_process atrioventricular valve formation;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003220,biological_process left ventricular cardiac muscle tissue morphogenesis;GO:0003251,biological_process positive regulation of cell proliferation involved in heart valve morphogenesis;GO:0003279,biological_process cardiac septum development;GO:0003360,biological_process brainstem development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007183,biological_process SMAD protein complex assembly;GO:0007283,biological_process spermatogenesis;GO:0007338,biological_process single fertilization;GO:0007369,biological_process gastrulation;GO:0007411,biological_process axon guidance;GO:0007492,biological_process endoderm development;GO:0007498,biological_process mesoderm development;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0008585,biological_process female gonad development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010614,biological_process negative regulation of cardiac muscle hypertrophy;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0014033,biological_process neural crest cell differentiation;GO:0016579,biological_process protein deubiquitination;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030308,biological_process negative regulation of cell growth;GO:0030509,biological_process BMP signaling pathway;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030616,molecular_function transforming growth factor beta receptor, common-partner cytoplasmic mediator activity;GO:0032444,cellular_component activin responsive factor complex;GO:0032525,biological_process somite rostral/caudal axis specification;GO:0032909,biological_process regulation of transforming growth factor beta2 production;GO:0033686,biological_process positive regulation of luteinizing hormone secretion;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035556,biological_process intracellular signal transduction;GO:0036302,biological_process atrioventricular canal development;GO:0042118,biological_process endothelial cell activation;GO:0042127,biological_process regulation of cell proliferation;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043199,molecular_function sulfate binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046881,biological_process positive regulation of follicle-stimulating hormone secretion;GO:0046982,molecular_function protein heterodimerization activity;GO:0048589,biological_process developmental growth;GO:0048663,biological_process neuron fate commitment;GO:0048729,biological_process tissue morphogenesis;GO:0048733,biological_process sebaceous gland development;GO:0048859,biological_process formation of anatomical boundary;GO:0051098,biological_process regulation of binding;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0051797,biological_process regulation of hair follicle development;GO:0060021,biological_process palate development;GO:0060065,biological_process uterus development;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060395,biological_process SMAD protein signal transduction;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060548,biological_process negative regulation of cell death;GO:0060956,biological_process endocardial cell differentiation;GO:0061040,biological_process female gonad morphogenesis;GO:0070102,biological_process interleukin-6-mediated signaling pathway;GO:0070207,biological_process protein homotrimerization;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070411,molecular_function I-SMAD binding;GO:0070412,molecular_function R-SMAD binding;GO:0071141,cellular_component SMAD protein complex;GO:0071559,biological_process response to transforming growth factor beta;GO:0071773,biological_process cellular response to BMP stimulus;GO:0072133,biological_process metanephric mesenchyme morphogenesis;GO:0072134,biological_process nephrogenic mesenchyme morphogenesis;GO:0072520,biological_process seminiferous tubule development;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1901522,biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:1905305,biological_process negative regulation of cardiac myofibril assembly;GO:2000617,biological_process positive regulation of histone H3-K9 acetylation	SMAD4; mothers against decapentaplegic homolog 4; K04501	SMAD family member 4 [Source:HGNC Symbol%3BAcc:HGNC:6770]
ENSG00000008256	23.48	25.48	22.45	25.33	25.47	22.79	-0.0354117866331484	4.86419868752851	0.702360736848524	0.918500192425276	7:6161775-6272644:-	CYTH3	18;GO:0000139,cellular_component Golgi membrane;GO:0001726,cellular_component ruffle;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045785,biological_process positive regulation of cell adhesion;GO:0048193,biological_process Golgi vesicle transport;GO:0090162,biological_process establishment of epithelial cell polarity	NA	cytohesin 3 [Source:HGNC Symbol%3BAcc:HGNC:9504]
ENSG00000176222	0.59	0.86	0.40	0.63	0.50	0.93	-0.187614193245653	0.297480244103446	0.702563443562307	0.91866849520056	19:43872362-43901385:-	ZNF404	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 404 [Source:HGNC Symbol%3BAcc:HGNC:19417]
ENSG00000110318	2.53	2.59	2.81	2.20	2.66	2.86	0.0500153213564147	3.57328722845274	0.702692927406896	0.918741026743396	11:101915014-102001058:+	CEP126	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007052,biological_process mitotic spindle organization;GO:0030030,biological_process cell projection organization;GO:0030496,cellular_component midbody;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097546,cellular_component ciliary base;GO:1905515,biological_process non-motile cilium assembly	NA	centrosomal protein 126 [Source:HGNC Symbol%3BAcc:HGNC:29264]
ENSG00000114737	5.18	4.86	5.57	4.87	5.65	6.07	-0.0720871224165605	2.2354805306424	0.702893998903426	0.91882486338735	3:50606489-50611831:-	CISH	18;GO:0001558,biological_process regulation of cell growth;GO:0003674,molecular_function molecular_function;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0043687,biological_process post-translational protein modification;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway	CISH; cytokine inducible SH2-containing protein; K04701	cytokine inducible SH2 containing protein [Source:HGNC Symbol%3BAcc:HGNC:1984]
ENSG00000085832	23.02	22.90	25.41	25.68	22.91	24.75	-0.0274132933629943	6.02316482460071	0.702905091656028	0.91882486338735	1:51354262-51519328:-	EPS15	39;GO:0001921,biological_process positive regulation of receptor recycling;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0006897,biological_process endocytosis;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0008283,biological_process cell proliferation;GO:0009925,cellular_component basal plasma membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016050,biological_process vesicle organization;GO:0016235,cellular_component aggresome;GO:0016324,cellular_component apical plasma membrane;GO:0017124,molecular_function SH3 domain binding;GO:0019065,biological_process receptor-mediated endocytosis of virus by host cell;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030132,cellular_component clathrin coat of coated pit;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031593,molecular_function polyubiquitin binding;GO:0031901,cellular_component early endosome membrane;GO:0032456,biological_process endocytic recycling;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0048268,biological_process clathrin coat assembly;GO:0060170,cellular_component ciliary membrane;GO:0061024,biological_process membrane organization	EPS15; epidermal growth factor receptor substrate 15; K12472	epidermal growth factor receptor pathway substrate 15 [Source:HGNC Symbol%3BAcc:HGNC:3419]
ENSG00000138735	0.98	1.19	0.86	0.93	1.03	0.87	0.0932873434247168	1.44660552780724	0.703041859930808	0.918906876626421	4:119494394-119628991:-	PDE5A	22;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004112,molecular_function cyclic-nucleotide phosphodiesterase activity;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008152,biological_process metabolic process;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0016787,molecular_function hydrolase activity;GO:0030553,molecular_function cGMP binding;GO:0030823,biological_process regulation of cGMP metabolic process;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0046068,biological_process cGMP metabolic process;GO:0046069,biological_process cGMP catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047555,molecular_function 3',5'-cyclic-GMP phosphodiesterase activity;GO:0055118,biological_process negative regulation of cardiac muscle contraction;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060282,biological_process positive regulation of oocyte development	PDE5; cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35]; K13762	phosphodiesterase 5A [Source:HGNC Symbol%3BAcc:HGNC:8784]
ENSG00000130962	4.55	6.69	6.06	7.29	6.87	4.34	-0.0932766188770522	2.15892305573567	0.703236754429697	0.919064838148645	X:37349274-37457295:+	PRRG1	5;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	proline rich and Gla domain 1 [Source:HGNC Symbol%3BAcc:HGNC:9469]
ENSG00000162650	1.39	1.47	1.66	1.66	1.59	1.56	-0.0757288432236748	1.92595666106156	0.703379795460564	0.919118471989376	1:109483478-109492804:+	ATXN7L2	NA	NA	ataxin 7 like 2 [Source:HGNC Symbol%3BAcc:HGNC:28713]
ENSG00000174775	29.40	28.20	26.06	27.82	26.01	28.26	0.0377805691187526	4.12770304546128	0.703425882856607	0.919118471989376	11:532241-537287:-	HRAS	66;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0006935,biological_process chemotaxis;GO:0007050,biological_process cell cycle arrest;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0007411,biological_process axon guidance;GO:0007569,biological_process cell aging;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030335,biological_process positive regulation of cell migration;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035900,biological_process response to isolation stress;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042088,biological_process T-helper 1 type immune response;GO:0042832,biological_process defense response to protozoan;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045740,biological_process positive regulation of DNA replication;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0051291,biological_process protein heterooligomerization;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071480,biological_process cellular response to gamma radiation;GO:0090303,biological_process positive regulation of wound healing;GO:0090398,biological_process cellular senescence;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1900029,biological_process positive regulation of ruffle assembly;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization;GO:2000630,biological_process positive regulation of miRNA metabolic process	HRAS; GTPase HRas; K02833	HRas proto-oncogene%2C GTPase [Source:HGNC Symbol%3BAcc:HGNC:5173]
ENSG00000152242	11.27	10.92	10.02	11.10	10.27	10.21	0.0396927267099772	3.82838872590895	0.703509600714253	0.919131109742766	18:46173552-46266991:+	C18orf25	6;GO:0000209,biological_process protein polyubiquitination;GO:0005515,molecular_function protein binding;GO:0016874,molecular_function ligase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	chromosome 18 open reading frame 25 [Source:HGNC Symbol%3BAcc:HGNC:28172]
ENSG00000188171	2.35	1.46	2.96	2.40	2.15	2.79	-0.0861438279889302	2.18188460304468	0.703628318741821	0.919189467537595	19:20620060-20661596:-	ZNF626	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 626 [Source:HGNC Symbol%3BAcc:HGNC:30461]
ENSG00000196405	15.76	17.86	17.58	18.24	16.68	17.78	-0.034103950627216	5.00880248886744	0.703711742837647	0.919201711443093	14:99971448-100144236:+	EVL	23;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0007015,biological_process actin filament organization;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0008154,biological_process actin polymerization or depolymerization;GO:0009887,biological_process organ morphogenesis;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0030027,cellular_component lamellipodium;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0042995,cellular_component cell projection;GO:0045010,biological_process actin nucleation;GO:0051289,biological_process protein homotetramerization;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:1900028,biological_process negative regulation of ruffle assembly	NA	Enah/Vasp-like [Source:HGNC Symbol%3BAcc:HGNC:20234]
ENSG00000149187	27.71	26.90	32.17	28.84	30.49	30.14	-0.029450113346001	5.50866989412912	0.703866546269787	0.919255557581622	11:47465932-47565569:-	CELF1	23;GO:0000900,molecular_function translation repressor activity, nucleic acid binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0007281,biological_process germ cell development;GO:0007286,biological_process spermatid development;GO:0008380,biological_process RNA splicing;GO:0009790,biological_process embryo development;GO:0016020,cellular_component membrane;GO:0016246,biological_process RNA interference;GO:0017148,biological_process negative regulation of translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031369,molecular_function translation initiation factor binding;GO:0036002,molecular_function pre-mRNA binding;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042835,molecular_function BRE binding;GO:0043484,biological_process regulation of RNA splicing	NA	CUGBP Elav-like family member 1 [Source:HGNC Symbol%3BAcc:HGNC:2549]
ENSG00000164631	18.91	17.09	20.98	19.59	18.79	17.89	0.0353428264671642	5.31105715135691	0.703901077484357	0.919255557581622	7:6688432-6706923:-	ZNF12	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 12 [Source:HGNC Symbol%3BAcc:HGNC:12902]
ENSG00000070950	8.34	7.43	7.53	7.76	6.28	8.62	0.0534987439126064	3.62182643461601	0.703999954204505	0.919287968813436	3:8775401-8963773:-	RAD18	33;GO:0000403,molecular_function Y-form DNA binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006301,biological_process postreplication repair;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0031593,molecular_function polyubiquitin binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0035861,cellular_component site of double-strand break;GO:0042405,cellular_component nuclear inclusion body;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042802,molecular_function identical protein binding;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0051984,biological_process positive regulation of chromosome segregation;GO:0060548,biological_process negative regulation of cell death;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0097505,cellular_component Rad6-Rad18 complex	NA	RAD18%2C E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:18278]
ENSG00000258429	4.55	5.51	4.75	3.08	5.31	5.50	0.0915523539907653	1.85776153890329	0.704208699713274	0.919463825553894	16:69328620-69330595:-	PDF	9;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016787,molecular_function hydrolase activity;GO:0018206,biological_process peptidyl-methionine modification;GO:0031365,biological_process N-terminal protein amino acid modification;GO:0042586,molecular_function peptide deformylase activity;GO:0043686,biological_process co-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	peptide deformylase (mitochondrial) [Source:HGNC Symbol%3BAcc:HGNC:30012]
ENSG00000144802	91.09	100.31	95.98	88.60	104.01	91.47	0.0279219558795205	7.68218641550188	0.704828199007823	0.92001116648397	3:101827990-101861022:+	NFKBIZ	9;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006954,biological_process inflammatory response;GO:0016607,cellular_component nuclear speck	NFKBIZ; NF-kappa-B inhibitor zeta; K14242	NFKB inhibitor zeta [Source:HGNC Symbol%3BAcc:HGNC:29805]
ENSG00000172216	98.19	72.67	83.56	83.12	75.84	105.78	-0.0439792815017152	6.49078752768199	0.704832018604791	0.92001116648397	20:50190733-50192689:+	CEBPB	65;GO:0000779,cellular_component condensed chromosome, centromeric region;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001541,biological_process ovarian follicle development;GO:0001889,biological_process liver development;GO:0001892,biological_process embryonic placenta development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006953,biological_process acute-phase response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007613,biological_process memory;GO:0008134,molecular_function transcription factor binding;GO:0016363,cellular_component nuclear matrix;GO:0019900,molecular_function kinase binding;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0032496,biological_process response to lipopolysaccharide;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0036488,cellular_component CHOP-C/EBP complex;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042742,biological_process defense response to bacterium;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0045408,biological_process regulation of interleukin-6 biosynthetic process;GO:0045444,biological_process fat cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045670,biological_process regulation of osteoclast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0050873,biological_process brown fat cell differentiation;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0060850,biological_process regulation of transcription involved in cell fate commitment;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071347,biological_process cellular response to interleukin-1;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0072574,biological_process hepatocyte proliferation;GO:0097421,biological_process liver regeneration;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	CEBPB; CCAAT/enhancer binding protein (C/EBP), beta; K10048	CCAAT/enhancer binding protein beta [Source:HGNC Symbol%3BAcc:HGNC:1834]
ENSG00000149150	12.28	9.86	12.01	12.04	11.31	10.19	0.0473190703331816	4.27516358545601	0.705097084080989	0.92001116648397	11:57484533-57515786:-	SLC43A1	14;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015179,molecular_function L-amino acid transmembrane transporter activity;GO:0015804,biological_process neutral amino acid transport;GO:0015807,biological_process L-amino acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:1902475,biological_process L-alpha-amino acid transmembrane transport	NA	solute carrier family 43 member 1 [Source:HGNC Symbol%3BAcc:HGNC:9225]
ENSG00000078369	269.49	271.42	265.54	277.10	270.95	277.34	-0.0219046694185312	8.11758614210279	0.705239742220912	0.92001116648397	1:1785284-1891117:-	GNB1	44;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007191,biological_process adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007213,biological_process G-protein coupled acetylcholine receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0008283,biological_process cell proliferation;GO:0010659,biological_process cardiac muscle cell apoptotic process;GO:0016020,cellular_component membrane;GO:0016056,biological_process rhodopsin mediated signaling pathway;GO:0030168,biological_process platelet activation;GO:0030425,cellular_component dendrite;GO:0030507,molecular_function spectrin binding;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0032403,molecular_function protein complex binding;GO:0042622,cellular_component photoreceptor outer segment membrane;GO:0043209,cellular_component myelin sheath;GO:0044297,cellular_component cell body;GO:0047391,molecular_function alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0050909,biological_process sensory perception of taste;GO:0051020,molecular_function GTPase binding;GO:0060041,biological_process retina development in camera-type eye;GO:0070062,cellular_component extracellular exosome;GO:0070208,biological_process protein heterotrimerization;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0071870,biological_process cellular response to catecholamine stimulus;GO:0097381,cellular_component photoreceptor disc membrane;GO:1903561,cellular_component extracellular vesicle	GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; K04536	G protein subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:4396]
ENSG00000118432	4.14	4.66	4.68	4.44	5.36	3.13	0.0728005609999271	2.66789964369613	0.70534055847082	0.92001116648397	6:88139863-88166359:-	CNR1	52;GO:0002866,biological_process positive regulation of acute inflammatory response to antigenic stimulus;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004949,molecular_function cannabinoid receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007187,biological_process G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0007413,biological_process axonal fasciculation;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0007611,biological_process learning or memory;GO:0007613,biological_process memory;GO:0008144,molecular_function drug binding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019233,biological_process sensory perception of pain;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031622,biological_process positive regulation of fever generation;GO:0031999,biological_process negative regulation of fatty acid beta-oxidation;GO:0032228,biological_process regulation of synaptic transmission, GABAergic;GO:0032496,biological_process response to lipopolysaccharide;GO:0033004,biological_process negative regulation of mast cell activation;GO:0033602,biological_process negative regulation of dopamine secretion;GO:0035094,biological_process response to nicotine;GO:0038171,biological_process cannabinoid signaling pathway;GO:0042220,biological_process response to cocaine;GO:0042593,biological_process glucose homeostasis;GO:0042734,cellular_component presynaptic membrane;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043271,biological_process negative regulation of ion transport;GO:0043278,biological_process response to morphine;GO:0045121,cellular_component membrane raft;GO:0045471,biological_process response to ethanol;GO:0045759,biological_process negative regulation of action potential;GO:0045776,biological_process negative regulation of blood pressure;GO:0045777,biological_process positive regulation of blood pressure;GO:0050796,biological_process regulation of insulin secretion;GO:0051001,biological_process negative regulation of nitric-oxide synthase activity;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0060259,biological_process regulation of feeding behavior;GO:0060405,biological_process regulation of penile erection;GO:0099553,biological_process trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	CNR1; cannabinoid receptor 1; K04277	cannabinoid receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:2159]
ENSG00000168488	73.48	67.83	76.60	76.52	71.83	75.20	-0.0243315840379939	8.0460700781241	0.70534279414004	0.92001116648397	16:28823034-28837237:+	ATXN2L	12;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010603,biological_process regulation of cytoplasmic mRNA processing body assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0034063,biological_process stress granule assembly;GO:0045296,molecular_function cadherin binding	NA	ataxin 2 like [Source:HGNC Symbol%3BAcc:HGNC:31326]
ENSG00000133983	20.49	19.47	19.99	17.10	25.05	15.19	0.0812179518536878	2.69532313331158	0.705387191111336	0.92001116648397	14:70325080-70359731:-	COX16	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane	NA	COX16%2C cytochrome c oxidase assembly homolog [Source:HGNC Symbol%3BAcc:HGNC:20213]
ENSG00000161298	4.18	3.45	3.94	3.84	4.10	4.24	-0.0526873898782314	2.8503638522097	0.70540801703156	0.92001116648397	19:36604816-36634113:+	ZNF382	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 382 [Source:HGNC Symbol%3BAcc:HGNC:17409]
ENSG00000136709	20.22	20.62	20.34	19.71	20.32	20.63	0.0235528592507616	6.48697322097417	0.705413245497418	0.92001116648397	2:127701021-127811187:-	WDR33	15;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005581,cellular_component collagen trimer;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006301,biological_process postreplication repair;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006379,biological_process mRNA cleavage;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0007283,biological_process spermatogenesis;GO:0031124,biological_process mRNA 3'-end processing	PFS2; polyadenylation factor subunit 2; K15542	WD repeat domain 33 [Source:HGNC Symbol%3BAcc:HGNC:25651]
ENSG00000165240	2.79	2.51	2.63	2.73	2.71	2.31	0.0516229535907032	3.5767242920459	0.705459674043423	0.92001116648397	X:77910655-78050395:+	ATP7A	105;GO:0000166,molecular_function nucleotide binding;GO:0001568,biological_process blood vessel development;GO:0001701,biological_process in utero embryonic development;GO:0001889,biological_process liver development;GO:0001974,biological_process blood vessel remodeling;GO:0002082,biological_process regulation of oxidative phosphorylation;GO:0004008,molecular_function copper-exporting ATPase activity;GO:0005375,molecular_function copper ion transmembrane transporter activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0006568,biological_process tryptophan metabolic process;GO:0006584,biological_process catecholamine metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006825,biological_process copper ion transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0007005,biological_process mitochondrion organization;GO:0007595,biological_process lactation;GO:0007626,biological_process locomotory behavior;GO:0010041,biological_process response to iron(III) ion;GO:0010042,biological_process response to manganese ion;GO:0010043,biological_process response to zinc ion;GO:0010273,biological_process detoxification of copper ion;GO:0010288,biological_process response to lead ion;GO:0010468,biological_process regulation of gene expression;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0015677,biological_process copper ion import;GO:0015679,biological_process plasma membrane copper ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016532,molecular_function superoxide dismutase copper chaperone activity;GO:0016787,molecular_function hydrolase activity;GO:0018205,biological_process peptidyl-lysine modification;GO:0019430,biological_process removal of superoxide radicals;GO:0019730,biological_process antimicrobial humoral response;GO:0019829,molecular_function cation-transporting ATPase activity;GO:0021702,biological_process cerebellar Purkinje cell differentiation;GO:0021860,biological_process pyramidal neuron development;GO:0021954,biological_process central nervous system neuron development;GO:0030001,biological_process metal ion transport;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030141,cellular_component secretory granule;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031069,biological_process hair follicle morphogenesis;GO:0031252,cellular_component cell leading edge;GO:0031526,cellular_component brush border membrane;GO:0032767,molecular_function copper-dependent protein binding;GO:0034220,biological_process ion transmembrane transport;GO:0034760,biological_process negative regulation of iron ion transmembrane transport;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0042093,biological_process T-helper cell differentiation;GO:0042414,biological_process epinephrine metabolic process;GO:0042415,biological_process norepinephrine metabolic process;GO:0042417,biological_process dopamine metabolic process;GO:0042428,biological_process serotonin metabolic process;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043204,cellular_component perikaryon;GO:0043473,biological_process pigmentation;GO:0043588,biological_process skin development;GO:0045121,cellular_component membrane raft;GO:0045793,biological_process positive regulation of cell size;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0048251,biological_process elastic fiber assembly;GO:0048286,biological_process lung alveolus development;GO:0048365,molecular_function Rac GTPase binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048812,biological_process neuron projection morphogenesis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051087,molecular_function chaperone binding;GO:0051216,biological_process cartilage development;GO:0051353,biological_process positive regulation of oxidoreductase activity;GO:0051542,biological_process elastin biosynthetic process;GO:0060003,biological_process copper ion export;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071236,biological_process cellular response to antibiotic;GO:0071276,biological_process cellular response to cadmium ion;GO:0071279,biological_process cellular response to cobalt ion;GO:0071280,biological_process cellular response to copper ion;GO:0071281,biological_process cellular response to iron ion;GO:0071284,biological_process cellular response to lead ion;GO:0071456,biological_process cellular response to hypoxia;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport;GO:1903036,biological_process positive regulation of response to wounding;GO:1903136,molecular_function cuprous ion binding;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:1904959,biological_process regulation of cytochrome-c oxidase activity	NA	ATPase copper transporting alpha [Source:HGNC Symbol%3BAcc:HGNC:869]
ENSG00000230561	1.29	2.40	1.51	1.28	2.42	2.01	-0.160600749170491	0.785806146620556	0.705506621847786	0.92001116648397	5:127703388-127941634:+	CCDC192	NA	NA	coiled-coil domain containing 192 [Source:HGNC Symbol%3BAcc:HGNC:49566]
ENSG00000167733	6.43	5.85	8.11	6.01	6.85	6.94	0.0624265041416033	3.16119651221171	0.705517303936269	0.92001116648397	19:5680603-5688523:+	HSD11B1L	5;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0016491,molecular_function oxidoreductase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0055114,biological_process oxidation-reduction process	NA	hydroxysteroid 11-beta dehydrogenase 1 like [Source:HGNC Symbol%3BAcc:HGNC:30419]
ENSG00000176101	55.39	53.00	48.24	48.24	53.54	52.00	0.0377384422828664	4.21916047154759	0.705943218677728	0.920369259831008	9:137188646-137190370:+	SSNA1	14;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042802,molecular_function identical protein binding;GO:0060830,biological_process ciliary receptor clustering involved in smoothened signaling pathway;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	SS nuclear autoantigen 1 [Source:HGNC Symbol%3BAcc:HGNC:11321]
ENSG00000105948	9.91	10.58	10.24	10.15	9.21	10.78	0.0348203369730575	4.11141863980226	0.706052741328537	0.920369259831008	7:139133743-139191986:+	TTC26	13;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007224,biological_process smoothened signaling pathway;GO:0007286,biological_process spermatid development;GO:0015031,biological_process protein transport;GO:0030992,cellular_component intraciliary transport particle B;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip	NA	tetratricopeptide repeat domain 26 [Source:HGNC Symbol%3BAcc:HGNC:21882]
ENSG00000140740	100.61	98.30	91.23	92.55	100.19	94.67	0.0251429102043625	7.14689741689617	0.706114404708992	0.920369259831008	16:21952659-21983660:+	UQCRC2	21;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006119,biological_process oxidative phosphorylation;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0006508,biological_process proteolysis;GO:0006627,biological_process protein processing involved in protein targeting to mitochondrion;GO:0008270,molecular_function zinc ion binding;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0032403,molecular_function protein complex binding;GO:0043209,cellular_component myelin sheath;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain	QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2; K00415	ubiquinol-cytochrome c reductase core protein II [Source:HGNC Symbol%3BAcc:HGNC:12586]
ENSG00000148672	101.55	97.68	104.51	104.17	93.96	102.91	0.0251240429638113	7.40116921845753	0.706138945175034	0.920369259831008	10:87050485-87094866:-	GLUD1	24;GO:0000166,molecular_function nucleotide binding;GO:0004352,molecular_function glutamate dehydrogenase (NAD+) activity;GO:0004353,molecular_function glutamate dehydrogenase [NAD(P)+] activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006537,biological_process glutamate biosynthetic process;GO:0006538,biological_process glutamate catabolic process;GO:0006541,biological_process glutamine metabolic process;GO:0007005,biological_process mitochondrion organization;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0021762,biological_process substantia nigra development;GO:0032024,biological_process positive regulation of insulin secretion;GO:0042802,molecular_function identical protein binding;GO:0043531,molecular_function ADP binding;GO:0055114,biological_process oxidation-reduction process;GO:0070403,molecular_function NAD+ binding;GO:0070728,molecular_function leucine binding;GO:0072350,biological_process tricarboxylic acid metabolic process	GLUD1_2, gdhA; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]; K00261	glutamate dehydrogenase 1 [Source:HGNC Symbol%3BAcc:HGNC:4335]
ENSG00000185619	23.97	23.45	26.57	24.63	26.53	25.06	-0.0281826570533539	5.26912055838257	0.706229751766794	0.920369259831008	4:705747-770640:+	PCGF3	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031519,cellular_component PcG protein complex;GO:0046872,molecular_function metal ion binding	PCGF3; polycomb group RING finger protein 3; K11488	polycomb group ring finger 3 [Source:HGNC Symbol%3BAcc:HGNC:10066]
ENSG00000172057	33.24	32.27	34.64	33.44	31.39	33.55	0.03941637417432	3.94107926547386	0.706236784007923	0.920369259831008	17:39921040-39927601:-	ORMDL3	13;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006672,biological_process ceramide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030667,cellular_component secretory granule membrane;GO:0035339,cellular_component SPOTS complex;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0090156,biological_process cellular sphingolipid homeostasis;GO:1900060,biological_process negative regulation of ceramide biosynthetic process	NA	ORMDL sphingolipid biosynthesis regulator 3 [Source:HGNC Symbol%3BAcc:HGNC:16038]
ENSG00000152492	60.71	54.66	60.47	62.60	56.65	61.47	-0.0256075541017882	6.42969102820855	0.706430373787432	0.920474701430259	3:191329076-191398670:+	CCDC50	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007605,biological_process sensory perception of sound;GO:0031625,molecular_function ubiquitin protein ligase binding	NA	coiled-coil domain containing 50 [Source:HGNC Symbol%3BAcc:HGNC:18111]
ENSG00000152348	6.65	8.68	5.68	7.90	6.63	7.58	-0.0811401918456133	2.688038251964	0.706466001814717	0.920474701430259	5:81972024-82276857:+	ATG10	13;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006497,biological_process protein lipidation;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0006983,biological_process ER overload response;GO:0015031,biological_process protein transport;GO:0016236,biological_process macroautophagy;GO:0016874,molecular_function ligase activity;GO:0019777,molecular_function Atg12 transferase activity;GO:0031401,biological_process positive regulation of protein modification process;GO:0032446,biological_process protein modification by small protein conjugation	NA	autophagy related 10 [Source:HGNC Symbol%3BAcc:HGNC:20315]
ENSG00000130520	67.33	72.33	61.57	68.83	64.01	74.05	-0.0316392575054611	6.00500710942663	0.706581202807338	0.920528176999107	19:18306229-18323274:-	LSM4	24;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005688,cellular_component U6 snRNP;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0017070,molecular_function U6 snRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0042731,molecular_function PH domain binding;GO:0043005,cellular_component neuron projection;GO:0043234,cellular_component protein complex;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0097526,cellular_component spliceosomal tri-snRNP complex	LSM4; U6 snRNA-associated Sm-like protein LSm4; K12623	LSM4 homolog%2C U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol%3BAcc:HGNC:17259]
ENSG00000083845	756.27	749.66	741.90	782.99	741.91	775.69	-0.0217247123671468	9.0005114309195	0.706735059820718	0.920585008745675	19:58386399-58394806:+	RPS5	23;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006450,biological_process regulation of translational fidelity;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein S5 [Source:HGNC Symbol%3BAcc:HGNC:10426]
ENSG00000136141	9.07	7.93	8.69	8.18	8.89	9.56	-0.0352868825694071	4.40085934725188	0.706806819693296	0.920585008745675	13:46553167-46753040:+	LRCH1	3;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction	NA	leucine rich repeats and calponin homology domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20309]
ENSG00000125445	65.81	73.86	55.48	67.37	67.03	66.72	-0.0356485927206971	5.95515249544876	0.706934629355894	0.920585008745675	17:75261673-75266373:+	MRPS7	14;GO:0000028,biological_process ribosomal small subunit assembly;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0019843,molecular_function rRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7; K02992	mitochondrial ribosomal protein S7 [Source:HGNC Symbol%3BAcc:HGNC:14499]
ENSG00000164758	38.88	41.16	41.07	41.08	40.19	43.59	-0.0354455214379687	4.4630073744853	0.707019345200399	0.920585008745675	8:117520712-117540262:+	MED30	21;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003712,molecular_function transcription cofactor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0061630,molecular_function ubiquitin protein ligase activity	MED30; mediator of RNA polymerase II transcription subunit 30; K15143	mediator complex subunit 30 [Source:HGNC Symbol%3BAcc:HGNC:23032]
ENSG00000154723	165.70	186.54	163.66	160.72	175.20	173.77	0.0257841693948525	6.15434396812199	0.70704194097533	0.920585008745675	21:25716502-25735673:-	ATP5J	19;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005215,molecular_function transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0021762,biological_process substantia nigra development;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046034,biological_process ATP metabolic process	ATPeF0F6, ATP5J; F-type H+-transporting ATPase subunit 6; K02131	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit F6 [Source:HGNC Symbol%3BAcc:HGNC:847]
ENSG00000215041	6.04	5.85	5.67	5.72	5.53	6.07	0.030578456720989	4.78168914738013	0.707069803704283	0.920585008745675	17:7315627-7329393:-	NEURL4	4;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton	NA	neuralized E3 ubiquitin protein ligase 4 [Source:HGNC Symbol%3BAcc:HGNC:34410]
ENSG00000161835	1.17	0.87	0.30	1.18	0.88	0.64	-0.18631016093591	0.220890116301317	0.70727397864392	0.920752144076117	12:52006939-52015889:+	GRASP	12;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0008104,biological_process protein localization;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030306,molecular_function ADP-ribosylation factor binding;GO:0042802,molecular_function identical protein binding;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	general receptor for phosphoinositides 1 associated scaffold protein [Source:HGNC Symbol%3BAcc:HGNC:18707]
ENSG00000064393	38.14	38.01	37.85	36.12	39.93	36.96	0.0244274082047194	7.12502033187935	0.707346527504217	0.920752144076117	7:139561569-139777778:-	HIPK2	62;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001654,biological_process eye development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003714,molecular_function transcription corepressor activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007224,biological_process smoothened signaling pathway;GO:0007628,biological_process adult walking behavior;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008344,biological_process adult locomotory behavior;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010842,biological_process retina layer formation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019048,biological_process modulation by virus of host morphology or physiology;GO:0030182,biological_process neuron differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030578,biological_process PML body organization;GO:0032092,biological_process positive regulation of protein binding;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043388,biological_process positive regulation of DNA binding;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046332,molecular_function SMAD binding;GO:0046790,molecular_function virion binding;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0050882,biological_process voluntary musculoskeletal movement;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051726,biological_process regulation of cell cycle;GO:0060059,biological_process embryonic retina morphogenesis in camera-type eye;GO:0060235,biological_process lens induction in camera-type eye;GO:0060395,biological_process SMAD protein signal transduction;GO:0061072,biological_process iris morphogenesis;GO:0071456,biological_process cellular response to hypoxia;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]; K08826	homeodomain interacting protein kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:14402]
ENSG00000105705	17.88	18.38	18.10	19.56	18.36	17.93	-0.0281747139678025	5.26886810069575	0.707538859013344	0.92078456052736	19:19276017-19320844:-	SUGP1	10;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing	NA	SURP and G-patch domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18643]
ENSG00000136937	22.60	23.01	22.69	20.78	23.17	23.64	0.025904121456807	5.81332371974384	0.707567174684659	0.92078456052736	9:97633625-97673748:+	NCBP1	43;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000245,biological_process spliceosomal complex assembly;GO:0000339,molecular_function RNA cap binding;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005845,cellular_component mRNA cap binding complex;GO:0005846,cellular_component nuclear cap binding complex;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0006810,biological_process transport;GO:0008334,biological_process histone mRNA metabolic process;GO:0008380,biological_process RNA splicing;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0030307,biological_process positive regulation of cell growth;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031047,biological_process gene silencing by RNA;GO:0031053,biological_process primary miRNA processing;GO:0031124,biological_process mRNA 3'-end processing;GO:0031442,biological_process positive regulation of mRNA 3'-end processing;GO:0034518,cellular_component RNA cap binding complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0051028,biological_process mRNA transport;GO:0051168,biological_process nuclear export;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation;GO:1905216,biological_process positive regulation of RNA binding	NCBP1, CBP80; nuclear cap-binding protein subunit 1; K12882	nuclear cap binding protein subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:7658]
ENSG00000171574	11.87	10.27	14.09	13.92	11.39	12.49	-0.0421931898276994	4.18174842808294	0.707593967845846	0.92078456052736	19:58401503-58418327:+	ZNF584	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 584 [Source:HGNC Symbol%3BAcc:HGNC:27318]
ENSG00000075292	27.12	23.47	26.92	25.48	25.20	26.11	0.0268303430033863	7.38164756167515	0.707775574531765	0.920889640833821	2:71276560-71435069:+	ZNF638	14;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 638 [Source:HGNC Symbol%3BAcc:HGNC:17894]
ENSG00000090372	35.17	33.89	36.04	35.68	34.49	37.67	-0.0245060987949848	6.48565561240318	0.707823093788406	0.920889640833821	19:46719506-46746994:-	STRN4	13;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0032403,molecular_function protein complex binding;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043234,cellular_component protein complex;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070016,molecular_function armadillo repeat domain binding	NA	striatin 4 [Source:HGNC Symbol%3BAcc:HGNC:15721]
ENSG00000144554	10.87	11.69	8.98	10.86	11.30	10.36	-0.0361296922075023	5.60936215853719	0.707963754090075	0.920976113971924	3:10026413-10101930:+	FANCD2	22;GO:0000793,cellular_component condensed chromosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007129,biological_process synapsis;GO:0007276,biological_process gamete generation;GO:0010332,biological_process response to gamma radiation;GO:0016604,cellular_component nuclear body;GO:0034599,biological_process cellular response to oxidative stress;GO:0036297,biological_process interstrand cross-link repair;GO:0045589,biological_process regulation of regulatory T cell differentiation;GO:0048854,biological_process brain morphogenesis;GO:0050727,biological_process regulation of inflammatory response;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0070182,molecular_function DNA polymerase binding;GO:0097150,biological_process neuronal stem cell population maintenance;GO:2000348,biological_process regulation of CD40 signaling pathway	FANCD2; fanconi anemia group D2 protein; K10891	Fanconi anemia complementation group D2 [Source:HGNC Symbol%3BAcc:HGNC:3585]
ENSG00000153944	18.64	20.78	22.96	21.07	22.74	20.65	-0.0359140988756089	4.80077756099037	0.708323333434327	0.921266703601366	17:57255850-57684685:+	MSI2	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0008266,molecular_function poly(U) RNA binding;GO:0048864,biological_process stem cell development	MSI; RNA-binding protein Musashi; K14411	musashi RNA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18585]
ENSG00000122515	41.77	42.29	48.09	46.74	44.58	44.45	-0.0264910337790618	6.9552532928953	0.708337271742292	0.921266703601366	7:44748580-44769881:+	ZMIZ2	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0043596,cellular_component nuclear replication fork;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger MIZ-type containing 2 [Source:HGNC Symbol%3BAcc:HGNC:22229]
ENSG00000198840	3126.32	2899.01	3125.07	3123.20	2913.14	3044.21	0.0229117148157031	10.0392350114892	0.708581978459001	0.921266703601366	MT:10058-10404:+	MT-ND3	17;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006979,biological_process response to oxidative stress;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009642,biological_process response to light intensity;GO:0009725,biological_process response to hormone;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:0071385,biological_process cellular response to glucocorticoid stimulus	ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]; K03880	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:7458]
ENSG00000139746	14.14	16.72	15.38	15.85	16.13	15.53	-0.0314326425309822	5.58131960348822	0.708591091702247	0.921266703601366	13:79311823-79406477:-	RBM26	6;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0006397,biological_process mRNA processing;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0046872,molecular_function metal ion binding	NA	RNA binding motif protein 26 [Source:HGNC Symbol%3BAcc:HGNC:20327]
ENSG00000175198	23.05	20.41	19.97	19.38	21.89	21.44	0.0302566451686097	5.75653398448685	0.70862193998264	0.921266703601366	13:100089014-100530437:+	PCCA	14;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004075,molecular_function biotin carboxylase activity;GO:0004658,molecular_function propionyl-CoA carboxylase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006768,biological_process biotin metabolic process;GO:0009374,molecular_function biotin binding;GO:0016874,molecular_function ligase activity;GO:0019626,biological_process short-chain fatty acid catabolic process;GO:0019899,molecular_function enzyme binding;GO:0046872,molecular_function metal ion binding	PCCA, pccA; propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]; K01965	propionyl-CoA carboxylase alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:8653]
ENSG00000161970	20.67	16.33	13.16	16.77	17.88	18.24	-0.0611476639677868	3.1573328586543	0.708668221990307	0.921266703601366	17:8377519-8383213:-	RPL26	33;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0015934,cellular_component large ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0022626,cellular_component cytosolic ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0034644,biological_process cellular response to UV;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0045727,biological_process positive regulation of translation;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070062,cellular_component extracellular exosome;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071480,biological_process cellular response to gamma radiation;GO:1902164,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:1902167,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1904803,biological_process regulation of translation involved in cellular response to UV;GO:1990904,cellular_component ribonucleoprotein complex	NA	ribosomal protein L26 [Source:HGNC Symbol%3BAcc:HGNC:10327]
ENSG00000205544	27.64	32.41	23.47	30.82	25.72	30.57	-0.061876247217425	3.31185957254488	0.708706658558724	0.921266703601366	17:7402974-7404137:-	TMEM256	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	transmembrane protein 256 [Source:HGNC Symbol%3BAcc:HGNC:28618]
ENSG00000136518	70.41	74.03	69.86	68.34	73.14	78.48	-0.027257280827232	6.57868093817891	0.708811137422061	0.921306036525658	3:179562879-179588408:+	ACTL6A	35;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003407,biological_process neural retina development;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0021510,biological_process spinal cord development;GO:0031011,cellular_component Ino80 complex;GO:0031492,molecular_function nucleosomal DNA binding;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0071564,cellular_component npBAF complex;GO:0090544,cellular_component BAF-type complex;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	ACTL6A, INO80K; actin-like protein 6A; K11340	actin like 6A [Source:HGNC Symbol%3BAcc:HGNC:24124]
ENSG00000170522	52.28	68.19	44.57	50.61	54.86	55.55	0.0420324159380371	5.48480183454883	0.708974868053231	0.921325447266637	4:110045845-110199199:-	ELOVL6	25;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0009922,molecular_function fatty acid elongase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0019367,biological_process fatty acid elongation, saturated fatty acid;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030497,biological_process fatty acid elongation;GO:0034625,biological_process fatty acid elongation, monounsaturated fatty acid;GO:0034626,biological_process fatty acid elongation, polyunsaturated fatty acid;GO:0035338,biological_process long-chain fatty-acyl-CoA biosynthetic process;GO:0042759,biological_process long-chain fatty acid biosynthetic process;GO:0042761,biological_process very long-chain fatty acid biosynthetic process;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0102336,molecular_function 3-oxo-arachidoyl-CoA synthase activity;GO:0102337,molecular_function 3-oxo-cerotoyl-CoA synthase activity;GO:0102338,molecular_function 3-oxo-lignoceronyl-CoA synthase activity	ELOVL6; elongation of very long chain fatty acids protein 6 [EC:2.3.1.199]; K10203	ELOVL fatty acid elongase 6 [Source:HGNC Symbol%3BAcc:HGNC:15829]
ENSG00000039139	0.60	0.57	0.50	0.52	0.61	0.62	-0.0602853522875474	3.01427770208506	0.709042981399229	0.921325447266637	5:13690330-13944543:-	DNAH5	28;GO:0000166,molecular_function nucleotide binding;GO:0003341,biological_process cilium movement;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005858,cellular_component axonemal dynein complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007018,biological_process microtubule-based movement;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0008150,biological_process biological_process;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0016887,molecular_function ATPase activity;GO:0021670,biological_process lateral ventricle development;GO:0030286,cellular_component dynein complex;GO:0030317,biological_process sperm motility;GO:0036157,cellular_component outer dynein arm;GO:0036158,biological_process outer dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis	NA	dynein axonemal heavy chain 5 [Source:HGNC Symbol%3BAcc:HGNC:2950]
ENSG00000180198	32.57	33.70	31.97	33.29	32.43	34.98	-0.0261932280420516	5.87195792661747	0.709048739042792	0.921325447266637	1:28505942-28539300:+	RCC1	28;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000790,cellular_component nuclear chromatin;GO:0000794,cellular_component condensed nuclear chromosome;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005087,molecular_function Ran guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007059,biological_process chromosome segregation;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008536,molecular_function Ran GTPase binding;GO:0016032,biological_process viral process;GO:0031491,molecular_function nucleosome binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031965,cellular_component nuclear membrane;GO:0042393,molecular_function histone binding;GO:0043199,molecular_function sulfate binding;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051225,biological_process spindle assembly;GO:0051290,biological_process protein heterotetramerization;GO:0051301,biological_process cell division	NA	regulator of chromosome condensation 1 [Source:HGNC Symbol%3BAcc:HGNC:1913]
ENSG00000143442	21.42	19.97	21.19	20.37	21.45	20.24	0.0256344455466304	6.50120522878942	0.709225122024818	0.921405141926533	1:151402723-151459465:-	POGZ	14;GO:0000790,cellular_component nuclear chromatin;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0051382,biological_process kinetochore assembly	NA	pogo transposable element derived with ZNF domain [Source:HGNC Symbol%3BAcc:HGNC:18801]
ENSG00000134744	19.78	19.12	21.11	19.72	20.78	18.94	0.0266369358081603	6.69228063515813	0.709320746406705	0.921405141926533	1:52408281-52553487:-	ZCCHC11	26;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0001816,biological_process cytokine production;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0010586,biological_process miRNA metabolic process;GO:0010587,biological_process miRNA catabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019827,biological_process stem cell population maintenance;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0031123,biological_process RNA 3'-end processing;GO:0031664,biological_process regulation of lipopolysaccharide-mediated signaling pathway;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0046872,molecular_function metal ion binding;GO:0050265,molecular_function RNA uridylyltransferase activity;GO:0070062,cellular_component extracellular exosome;GO:0070102,biological_process interleukin-6-mediated signaling pathway	NA	zinc finger CCHC-type containing 11 [Source:HGNC Symbol%3BAcc:HGNC:28981]
ENSG00000118600	15.27	12.19	15.76	15.75	11.79	17.73	-0.0507333893114663	4.34962578173212	0.709332758901954	0.921405141926533	12:63779802-63809558:+	TMEM5	9;GO:0000139,cellular_component Golgi membrane;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0006486,biological_process protein glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035269,biological_process protein O-linked mannosylation;GO:0120053,Molecular_Function ribitol beta-1,4-xylosyltransferase activity	NA	transmembrane protein 5 [Source:HGNC Symbol%3BAcc:HGNC:13530]
ENSG00000167965	28.46	28.44	31.18	29.24	30.70	30.73	-0.0284692628506211	5.06744118859238	0.709559135316273	0.921518520098233	16:2204247-2209416:+	MLST8	20;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007050,biological_process cell cycle arrest;GO:0016241,biological_process regulation of macroautophagy;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031295,biological_process T cell costimulation;GO:0031931,cellular_component TORC1 complex;GO:0031932,cellular_component TORC2 complex;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038202,biological_process TORC1 signaling;GO:0043087,biological_process regulation of GTPase activity;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:1900034,biological_process regulation of cellular response to heat	MLST8, GBL; target of rapamycin complex subunit LST8; K08266	MTOR associated protein%2C LST8 homolog [Source:HGNC Symbol%3BAcc:HGNC:24825]
ENSG00000040608	5.44	5.26	5.13	5.05	5.16	5.22	0.0495469004460175	3.23645261084291	0.709597878887516	0.921518520098233	22:20241414-20283246:-	RTN4R	41;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007409,biological_process axonogenesis;GO:0008201,molecular_function heparin binding;GO:0008289,molecular_function lipid binding;GO:0009986,cellular_component cell surface;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0022038,biological_process corpus callosum development;GO:0023041,biological_process neuronal signal transduction;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030517,biological_process negative regulation of axon extension;GO:0031225,cellular_component anchored component of membrane;GO:0031362,cellular_component anchored component of external side of plasma membrane;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035374,molecular_function chondroitin sulfate binding;GO:0038131,molecular_function neuregulin receptor activity;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043198,cellular_component dendritic shaft;GO:0043204,cellular_component perikaryon;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044295,cellular_component axonal growth cone;GO:0045121,cellular_component membrane raft;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0048681,biological_process negative regulation of axon regeneration;GO:0050771,biological_process negative regulation of axonogenesis;GO:0070062,cellular_component extracellular exosome;GO:1905573,molecular_function ganglioside GM1 binding;GO:1905576,molecular_function ganglioside GT1b binding	NA	reticulon 4 receptor [Source:HGNC Symbol%3BAcc:HGNC:18601]
ENSG00000076604	24.05	21.30	22.53	24.49	23.49	21.98	-0.0270407160365515	5.31059145776855	0.70971585067775	0.921518520098233	17:28743983-28750958:+	TRAF4	29;GO:0003677,molecular_function DNA binding;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0007275,biological_process multicellular organism development;GO:0007585,biological_process respiratory gaseous exchange;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030054,cellular_component cell junction;GO:0030323,biological_process respiratory tube development;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031996,molecular_function thioesterase binding;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050699,molecular_function WW domain binding;GO:0090073,biological_process positive regulation of protein homodimerization activity	TRAF4; TNF receptor-associated factor 4; K09848	TNF receptor associated factor 4 [Source:HGNC Symbol%3BAcc:HGNC:12034]
ENSG00000125970	143.10	144.29	135.58	141.26	144.83	147.22	-0.0238104530155573	7.03595032444904	0.709716994452518	0.921518520098233	20:33993645-34108308:+	RALY	15;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1903506,biological_process regulation of nucleic acid-templated transcription;GO:2000188,biological_process regulation of cholesterol homeostasis	NA	RALY heterogeneous nuclear ribonucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:15921]
ENSG00000181135	11.16	9.09	9.62	10.16	9.22	9.89	0.0490439314772441	3.59786077595909	0.710047438948305	0.921851151518179	8:143684451-143713898:+	ZNF707	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 707 [Source:HGNC Symbol%3BAcc:HGNC:27815]
ENSG00000169903	3.15	5.52	3.89	2.84	5.51	3.13	0.120209345057713	1.34340450553202	0.710154777371047	0.921894086122862	3:149473973-149503281:+	TM4SF4	4;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042246,biological_process tissue regeneration	NA	transmembrane 4 L six family member 4 [Source:HGNC Symbol%3BAcc:HGNC:11856]
ENSG00000064419	55.72	53.03	54.66	53.59	54.63	54.01	0.0228375829691321	7.28622452882904	0.710375940308806	0.92205885469868	7:128954179-129055173:-	TNPO3	12;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0031965,cellular_component nuclear membrane;GO:0035048,biological_process splicing factor protein import into nucleus;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	transportin 3 [Source:HGNC Symbol%3BAcc:HGNC:17103]
ENSG00000165424	2.73	3.29	3.17	2.50	3.18	3.02	0.0801115693339063	1.54331964645822	0.710444413895879	0.92205885469868	10:79382324-79445627:-	ZCCHC24	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 24 [Source:HGNC Symbol%3BAcc:HGNC:26911]
ENSG00000169902	64.77	70.17	64.58	67.25	72.56	64.93	-0.0273636346714933	6.227600817896	0.71050454726439	0.92205885469868	7:66205198-66420543:+	TPST1	9;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006478,biological_process peptidyl-tyrosine sulfation;GO:0006954,biological_process inflammatory response;GO:0008476,molecular_function protein-tyrosine sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process	NA	tyrosylprotein sulfotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:12020]
ENSG00000100379	13.56	17.36	15.71	14.23	15.84	15.47	0.0362180070288244	4.04483742631839	0.710595849394099	0.922080940678334	22:37051735-37063390:+	KCTD17	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0030030,biological_process cell projection organization;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032403,molecular_function protein complex binding;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045724,biological_process positive regulation of cilium assembly;GO:0051260,biological_process protein homooligomerization;GO:0097602,molecular_function cullin family protein binding	NA	potassium channel tetramerization domain containing 17 [Source:HGNC Symbol%3BAcc:HGNC:25705]
ENSG00000197601	32.83	31.02	29.61	30.12	30.70	31.72	0.0262901396829891	5.63414359861367	0.710778666838348	0.922221761415743	11:13668669-13732346:+	FAR1	14;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0006629,biological_process lipid metabolic process;GO:0008611,biological_process ether lipid biosynthetic process;GO:0010025,biological_process wax biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0035336,biological_process long-chain fatty-acyl-CoA metabolic process;GO:0046474,biological_process glycerophospholipid biosynthetic process;GO:0055114,biological_process oxidation-reduction process;GO:0080019,molecular_function fatty-acyl-CoA reductase (alcohol-forming) activity	FAR; alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84]; K13356	fatty acyl-CoA reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:26222]
ENSG00000115520	20.98	23.31	23.06	23.16	21.80	21.08	0.0366068827124705	4.03994451389208	0.711085595717391	0.9223831343869	2:197453422-197475308:+	COQ10B	6;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0045333,biological_process cellular respiration;GO:0048039,molecular_function ubiquinone binding	NA	coenzyme Q10B [Source:HGNC Symbol%3BAcc:HGNC:25819]
ENSG00000154864	0.44	0.30	0.27	0.38	0.31	0.40	-0.0905288764716465	1.68449270900535	0.711187196967149	0.9223831343869	18:10666482-11148762:-	PIEZO2	16;GO:0005261,molecular_function cation channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0008381,molecular_function mechanically-gated ion channel activity;GO:0009612,biological_process response to mechanical stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0042391,biological_process regulation of membrane potential;GO:0050896,biological_process response to stimulus;GO:0050974,biological_process detection of mechanical stimulus involved in sensory perception;GO:0050982,biological_process detection of mechanical stimulus;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0098655,biological_process cation transmembrane transport	NA	piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol%3BAcc:HGNC:26270]
ENSG00000048342	1.46	1.91	1.68	1.73	1.88	1.64	-0.05813534075225	3.14671794216946	0.711201662259837	0.9223831343869	4:15469864-15601557:+	CC2D2A	20;GO:0001843,biological_process neural tube closure;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0030030,biological_process cell projection organization;GO:0035082,biological_process axoneme assembly;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0044458,biological_process motile cilium assembly;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1904491,biological_process protein localization to ciliary transition zone;GO:1905515,biological_process non-motile cilium assembly;GO:1990403,biological_process embryonic brain development	NA	coiled-coil and C2 domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:29253]
ENSG00000106244	319.03	338.01	302.63	320.80	346.69	316.87	-0.025771010326124	7.49213490581136	0.711267392619004	0.9223831343869	7:99392047-99408829:-	PDAP1	6;GO:0003723,molecular_function RNA binding;GO:0005576,cellular_component extracellular region;GO:0007165,biological_process signal transduction;GO:0008283,biological_process cell proliferation;GO:0043312,biological_process neutrophil degranulation;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	PDGFA associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:14634]
ENSG00000182952	115.62	111.49	101.68	113.69	106.46	118.50	-0.0324701366632705	4.91701410437414	0.711274580065367	0.9223831343869	6:26538404-26546254:+	HMGN4	5;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0031492,molecular_function nucleosomal DNA binding	NA	high mobility group nucleosomal binding domain 4 [Source:HGNC Symbol%3BAcc:HGNC:4989]
ENSG00000187514	887.46	984.97	853.81	857.17	949.20	892.57	0.0261015315881629	9.45578277689068	0.711410052548918	0.922462444613989	2:231706894-231713541:+	PTMA	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0033613,molecular_function activating transcription factor binding;GO:0042393,molecular_function histone binding;GO:0043486,biological_process histone exchange;GO:0070062,cellular_component extracellular exosome	NA	prothymosin%2C alpha [Source:HGNC Symbol%3BAcc:HGNC:9623]
ENSG00000196152	2.79	3.77	3.30	3.61	2.49	3.29	0.0671458011148325	2.2986294678809	0.711632797947351	0.922558009675928	9:127424373-127445372:+	ZNF79	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 79 [Source:HGNC Symbol%3BAcc:HGNC:13153]
ENSG00000075651	11.12	10.25	10.89	10.74	10.29	10.94	0.0283450315922538	5.31894222501294	0.711711996571518	0.922558009675928	3:171600404-171810950:-	PLD1	30;GO:0000139,cellular_component Golgi membrane;GO:0003824,molecular_function catalytic activity;GO:0004630,molecular_function phospholipase D activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006935,biological_process chemotaxis;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0030139,cellular_component endocytic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0032534,biological_process regulation of microvillus assembly;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048870,biological_process cell motility;GO:0070290,molecular_function N-acylphosphatidylethanolamine-specific phospholipase D activity;GO:0070821,cellular_component tertiary granule membrane	PLD1_2; phospholipase D1/2 [EC:3.1.4.4]; K01115	phospholipase D1 [Source:HGNC Symbol%3BAcc:HGNC:9067]
ENSG00000107679	35.90	32.66	36.80	38.29	33.25	36.98	-0.0277067551242315	5.55708581673056	0.711714566887004	0.922558009675928	10:122374695-122442602:+	PLEKHA1	31;GO:0001553,biological_process luteinization;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007283,biological_process spermatogenesis;GO:0008209,biological_process androgen metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0008289,molecular_function lipid binding;GO:0008585,biological_process female gonad development;GO:0009791,biological_process post-embryonic development;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0030165,molecular_function PDZ domain binding;GO:0031529,biological_process ruffle organization;GO:0032587,cellular_component ruffle membrane;GO:0033327,biological_process Leydig cell differentiation;GO:0035264,biological_process multicellular organism growth;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0045184,biological_process establishment of protein localization;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048705,biological_process skeletal system morphogenesis;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide	NA	pleckstrin homology domain containing A1 [Source:HGNC Symbol%3BAcc:HGNC:14335]
ENSG00000145734	2.66	2.84	3.06	2.90	2.77	3.17	-0.0354720046884054	4.5254885398398	0.711891737375499	0.922558009675928	5:71455614-71567820:+	BDP1	11;GO:0000126,cellular_component transcription factor TFIIIB complex;GO:0001026,molecular_function TFIIIB-type transcription factor activity;GO:0001156,molecular_function TFIIIC-class transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0070898,biological_process RNA polymerase III transcriptional preinitiation complex assembly	NA	B double prime 1%2C subunit of RNA polymerase III transcription initiation factor IIIB [Source:HGNC Symbol%3BAcc:HGNC:13652]
ENSG00000145348	18.66	18.27	18.74	19.51	19.98	17.70	-0.0257671122279336	5.73641976851129	0.712039710456627	0.922558009675928	4:106041598-106321495:-	TBCK	18;GO:0004672,molecular_function protein kinase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006886,biological_process intracellular protein transport;GO:0008283,biological_process cell proliferation;GO:0012505,cellular_component endomembrane system;GO:0016049,biological_process cell growth;GO:0017137,molecular_function Rab GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030496,cellular_component midbody;GO:0031338,biological_process regulation of vesicle fusion;GO:0032006,biological_process regulation of TOR signaling;GO:0072686,cellular_component mitotic spindle;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain containing kinase [Source:HGNC Symbol%3BAcc:HGNC:28261]
ENSG00000104679	10.45	9.00	8.32	10.07	8.93	9.88	-0.0424452524787809	3.83018667658343	0.712056991787107	0.922558009675928	8:23270119-23296279:+	R3HCC1	2;GO:0003676,molecular_function nucleic acid binding;GO:0035145,cellular_component exon-exon junction complex	NA	R3H domain and coiled-coil containing 1 [Source:HGNC Symbol%3BAcc:HGNC:27329]
ENSG00000132122	5.56	6.49	5.98	6.95	5.29	6.57	-0.0581172084190988	3.2829773672233	0.712078020611491	0.922558009675928	1:48295371-48472208:-	SPATA6	8;GO:0005576,cellular_component extracellular region;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0032027,molecular_function myosin light chain binding;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0097224,cellular_component sperm connecting piece	NA	spermatogenesis associated 6 [Source:HGNC Symbol%3BAcc:HGNC:18309]
ENSG00000104915	60.82	58.20	63.06	62.15	59.23	65.59	-0.0250683672126471	5.85307429338949	0.712129262503975	0.922558009675928	19:13144057-13150383:-	STX10	24;GO:0000139,cellular_component Golgi membrane;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006906,biological_process vesicle fusion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0031201,cellular_component SNARE complex;GO:0031982,cellular_component vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0032880,biological_process regulation of protein localization;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0048193,biological_process Golgi vesicle transport;GO:0048278,biological_process vesicle docking;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061025,biological_process membrane fusion	STX6; syntaxin 6; K08498	syntaxin 10 [Source:HGNC Symbol%3BAcc:HGNC:11428]
ENSG00000106605	68.96	75.66	63.41	69.81	71.06	72.61	-0.0296781493439186	5.96599451355559	0.712174213307115	0.922558009675928	7:43758679-43807342:+	BLVRA	10;GO:0004074,molecular_function biliverdin reductase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0042167,biological_process heme catabolic process;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	BLVRA, bvdR; biliverdin reductase [EC:1.3.1.24]; K00214	biliverdin reductase A [Source:HGNC Symbol%3BAcc:HGNC:1062]
ENSG00000137818	1735.21	1509.94	1522.20	1597.83	1471.56	1649.80	0.0266071184357496	9.13402736413367	0.712407844463595	0.922558009675928	15:69452783-69456194:+	RPLP1	20;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006414,biological_process translational elongation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030295,molecular_function protein kinase activator activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032147,biological_process activation of protein kinase activity;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein lateral stalk subunit P1 [Source:HGNC Symbol%3BAcc:HGNC:10372]
ENSG00000170142	136.05	119.27	140.64	144.23	124.25	139.18	-0.0283129675565328	6.7002200341848	0.712518739500338	0.922558009675928	3:23805902-23891316:+	UBE2E1	24;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0010390,biological_process histone monoubiquitination;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0032020,biological_process ISG15-protein conjugation;GO:0033523,biological_process histone H2B ubiquitination;GO:0042296,molecular_function ISG15 transferase activity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070936,biological_process protein K48-linked ubiquitination	UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]; K06689	ubiquitin conjugating enzyme E2 E1 [Source:HGNC Symbol%3BAcc:HGNC:12477]
ENSG00000148444	15.53	13.35	14.44	11.68	14.88	15.57	0.0567431470205176	3.28813634869893	0.712679114148521	0.922558009675928	10:22315973-22320308:+	COMMD3	11;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0043312,biological_process neutrophil degranulation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PCGF4, BMI1; polycomb group RING finger protein 4; K11459	COMM domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:23332]
ENSG00000180008	12.04	10.86	10.98	10.83	11.84	10.65	0.040893190609475	3.90265239654864	0.712758348035767	0.922558009675928	14:55027229-55049488:+	SOCS4	12;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0009968,biological_process negative regulation of signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0046426,biological_process negative regulation of JAK-STAT cascade	SOCS4; suppressor of cytokine signaling 4; K04697	suppressor of cytokine signaling 4 [Source:HGNC Symbol%3BAcc:HGNC:19392]
ENSG00000103005	17.23	17.79	15.79	18.42	18.50	15.75	-0.0422241925419285	4.04757356944706	0.712767347762877	0.922558009675928	16:57999545-58021618:+	USB1	10;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0004518,molecular_function nuclease activity;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016787,molecular_function hydrolase activity;GO:0034477,biological_process U6 snRNA 3'-end processing;GO:0045171,cellular_component intercellular bridge;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	U6 snRNA biogenesis phosphodiesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:25792]
ENSG00000284308	1.00	1.16	0.86	0.95	1.11	0.75	0.105960184575515	1.03807395063745	0.712902465181582	0.922558009675928	2:74414175-74421591:-	C2orf81	1;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	chromosome 2 open reading frame 81 [Source:HGNC Symbol%3BAcc:HGNC:34350]
ENSG00000168040	46.07	47.78	37.98	43.80	41.57	44.06	0.0332921905999584	4.77033639539838	0.712924002866998	0.922558009675928	11:70203162-70207390:+	FADD	70;GO:0001916,biological_process positive regulation of T cell mediated cytotoxicity;GO:0002020,molecular_function protease binding;GO:0002376,biological_process immune system process;GO:0002821,biological_process positive regulation of adaptive immune response;GO:0005123,molecular_function death receptor binding;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0016032,biological_process viral process;GO:0031264,cellular_component death-inducing signaling complex;GO:0031265,cellular_component CD95 death-inducing signaling complex;GO:0032403,molecular_function protein complex binding;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032813,molecular_function tumor necrosis factor receptor superfamily binding;GO:0033077,biological_process T cell differentiation in thymus;GO:0033612,molecular_function receptor serine/threonine kinase binding;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0035877,molecular_function death effector domain binding;GO:0036462,biological_process TRAIL-activated apoptotic signaling pathway;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0042220,biological_process response to cocaine;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043005,cellular_component neuron projection;GO:0043029,biological_process T cell homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043278,biological_process response to morphine;GO:0044297,cellular_component cell body;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045862,biological_process positive regulation of proteolysis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048148,biological_process behavioral response to cocaine;GO:0048535,biological_process lymph node development;GO:0048536,biological_process spleen development;GO:0048538,biological_process thymus development;GO:0051607,biological_process defense response to virus;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway;GO:0060544,biological_process regulation of necroptotic process;GO:0060546,biological_process negative regulation of necroptotic process;GO:0070236,biological_process negative regulation of activation-induced cell death of T cells;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071550,biological_process death-inducing signaling complex assembly;GO:0089720,molecular_function caspase binding;GO:0097049,biological_process motor neuron apoptotic process;GO:0097190,biological_process apoptotic signaling pathway;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097342,cellular_component ripoptosome;GO:0097527,biological_process necroptotic signaling pathway;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000454,biological_process positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation;GO:2001238,biological_process positive regulation of extrinsic apoptotic signaling pathway	FADD; FAS-associated death domain protein; K02373	Fas associated via death domain [Source:HGNC Symbol%3BAcc:HGNC:3573]
ENSG00000116793	15.88	17.49	14.03	14.71	16.16	15.76	0.0300978667260608	5.21328745493865	0.712930827942413	0.922558009675928	1:113696830-113759489:-	PHTF1	9;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005801,cellular_component cis-Golgi network;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	putative homeodomain transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:8939]
ENSG00000255767	31.16	24.36	31.75	38.90	23.05	32.40	-0.0879167747543877	1.70723349840408	0.712966257539878	0.922558009675928	2:3531983-3547957:-	AC108488.2	3;GO:0003676,molecular_function nucleic acid binding;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]; K03469	NA
ENSG00000105072	7.17	7.95	8.22	8.17	6.58	8.06	0.0405636255197538	3.93622238888503	0.712967998099461	0.922558009675928	19:16496310-16521352:+	C19orf44	1;GO:0005515,molecular_function protein binding	NA	chromosome 19 open reading frame 44 [Source:HGNC Symbol%3BAcc:HGNC:26141]
ENSG00000112078	19.50	21.14	21.25	19.06	23.17	21.65	-0.035981076342723	4.72799705862287	0.713037079487122	0.922558009675928	6:36442766-36491143:+	KCTD20	4;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042327,biological_process positive regulation of phosphorylation	NA	potassium channel tetramerization domain containing 20 [Source:HGNC Symbol%3BAcc:HGNC:21052]
ENSG00000222046	6.41	7.67	6.40	7.01	7.39	6.98	-0.0631430269666325	2.89349347819199	0.713044513399731	0.922558009675928	1:32209093-32216196:+	DCDC2B	3;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0035556,biological_process intracellular signal transduction	NA	doublecortin domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:32576]
ENSG00000156931	11.89	11.06	11.74	10.89	11.41	13.44	-0.0300647185576014	5.76566073824195	0.713342573245928	0.922660653925503	3:184812142-185052614:+	VPS8	8;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0033263,cellular_component CORVET complex;GO:0034058,biological_process endosomal vesicle fusion;GO:0046872,molecular_function metal ion binding	NA	VPS8%2C CORVET complex subunit [Source:HGNC Symbol%3BAcc:HGNC:29122]
ENSG00000158526	39.57	39.86	39.31	39.20	42.49	40.62	-0.03154189626305	4.53500838200458	0.713427148276213	0.922660653925503	X:54440400-54445487:+	TSR2	4;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006364,biological_process rRNA processing	NA	TSR2%2C ribosome maturation factor [Source:HGNC Symbol%3BAcc:HGNC:25455]
ENSG00000069248	19.18	19.57	18.53	19.06	19.16	18.55	0.0233896582846525	6.04630339896168	0.713474531795628	0.922660653925503	1:229440259-229508341:-	NUP133	40;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0000972,biological_process transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006325,biological_process chromatin organization;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006999,biological_process nuclear pore organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0021915,biological_process neural tube development;GO:0022008,biological_process neurogenesis;GO:0031080,cellular_component nuclear pore outer ring;GO:0031081,biological_process nuclear pore distribution;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0048339,biological_process paraxial mesoderm development;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0061053,biological_process somite development;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP133; nuclear pore complex protein Nup133; K14300	nucleoporin 133 [Source:HGNC Symbol%3BAcc:HGNC:18016]
ENSG00000186591	119.77	115.70	122.85	125.42	126.70	115.60	-0.0240360758781633	6.35374657276168	0.713523828350259	0.922660653925503	7:129830731-129952949:-	UBE2H	15;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination	UBE2H, UBC8; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]; K10576	ubiquitin conjugating enzyme E2 H [Source:HGNC Symbol%3BAcc:HGNC:12484]
ENSG00000088854	11.88	9.80	13.24	11.11	10.68	12.57	0.0398699716532349	5.35957028462756	0.713525604217985	0.922660653925503	20:3249304-3407625:-	C20orf194	3;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	chromosome 20 open reading frame 194 [Source:HGNC Symbol%3BAcc:HGNC:17721]
ENSG00000167461	61.04	63.21	63.04	62.02	67.32	62.97	-0.0271792591371407	5.34768746628027	0.713569828219192	0.922660653925503	19:16111628-16134234:+	RAB8A	59;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006914,biological_process autophagy;GO:0007409,biological_process axonogenesis;GO:0008021,cellular_component synaptic vesicle;GO:0009306,biological_process protein secretion;GO:0010506,biological_process regulation of autophagy;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0017157,biological_process regulation of exocytosis;GO:0019003,molecular_function GDP binding;GO:0019901,molecular_function protein kinase binding;GO:0030030,biological_process cell projection organization;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030425,cellular_component dendrite;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031012,cellular_component extracellular matrix;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032880,biological_process regulation of protein localization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043687,biological_process post-translational protein modification;GO:0045335,cellular_component phagocytic vesicle;GO:0048169,biological_process regulation of long-term neuronal synaptic plasticity;GO:0048210,biological_process Golgi vesicle fusion to target membrane;GO:0051223,biological_process regulation of protein transport;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0060271,biological_process cilium morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane;GO:0097546,cellular_component ciliary base;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0097730,cellular_component non-motile cilium;GO:0098969,biological_process neurotransmitter receptor transport to postsynaptic membrane	RAB8A, MEL; Ras-related protein Rab-8A; K07901	RAB8A%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:7007]
ENSG00000112701	40.60	38.53	40.71	42.87	38.78	41.25	-0.0237091464964996	7.11224461653855	0.714015668244998	0.923140973849094	6:75601508-75718278:+	SENP6	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016925,biological_process protein sumoylation;GO:0016926,biological_process protein desumoylation;GO:0016929,molecular_function SUMO-specific protease activity;GO:0070646,biological_process protein modification by small protein removal;GO:0090169,biological_process regulation of spindle assembly;GO:0090234,biological_process regulation of kinetochore assembly	NA	SUMO1/sentrin specific peptidase 6 [Source:HGNC Symbol%3BAcc:HGNC:20944]
ENSG00000092201	55.37	55.66	55.68	58.94	53.01	58.91	-0.0238752085535989	7.58514343321452	0.714212564129178	0.923206591471983	14:21351471-21384266:-	SUPT16H	20;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006337,biological_process nucleosome disassembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0031491,molecular_function nucleosome binding;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0034724,biological_process DNA replication-independent nucleosome organization;GO:0035101,cellular_component FACT complex;GO:0042393,molecular_function histone binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	SPT16 homolog%2C facilitates chromatin remodeling subunit [Source:HGNC Symbol%3BAcc:HGNC:11465]
ENSG00000120253	24.39	24.69	25.93	27.79	22.99	26.59	-0.0332405595970694	4.8911573447234	0.714215169411541	0.923206591471983	6:149724314-149749665:-	NUP43	28;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031080,cellular_component nuclear pore outer ring;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0051301,biological_process cell division;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP43; nuclear pore complex protein Nup43; K14305	nucleoporin 43 [Source:HGNC Symbol%3BAcc:HGNC:21182]
ENSG00000105220	116.59	131.70	117.07	117.80	127.02	116.87	0.0253650244075904	7.76473698508924	0.714334112070642	0.923223982065295	19:34359479-34402156:+	GPI	46;GO:0001525,biological_process angiogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001707,biological_process mesoderm formation;GO:0004347,molecular_function glucose-6-phosphate isomerase activity;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0006959,biological_process humoral immune response;GO:0007599,biological_process hemostasis;GO:0007611,biological_process learning or memory;GO:0008083,molecular_function growth factor activity;GO:0016020,cellular_component membrane;GO:0016853,molecular_function isomerase activity;GO:0016866,molecular_function intramolecular transferase activity;GO:0019242,biological_process methylglyoxal biosynthetic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032355,biological_process response to estradiol;GO:0032570,biological_process response to progesterone;GO:0033574,biological_process response to testosterone;GO:0034101,biological_process erythrocyte homeostasis;GO:0034774,cellular_component secretory granule lumen;GO:0035902,biological_process response to immobilization stress;GO:0035994,biological_process response to muscle stretch;GO:0042593,biological_process glucose homeostasis;GO:0043005,cellular_component neuron projection;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043209,cellular_component myelin sheath;GO:0043278,biological_process response to morphine;GO:0043312,biological_process neutrophil degranulation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046185,biological_process aldehyde catabolic process;GO:0046686,biological_process response to cadmium ion;GO:0048029,molecular_function monosaccharide binding;GO:0051024,biological_process positive regulation of immunoglobulin secretion;GO:0051156,biological_process glucose 6-phosphate metabolic process;GO:0060170,cellular_component ciliary membrane;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]; K01810	glucose-6-phosphate isomerase [Source:HGNC Symbol%3BAcc:HGNC:4458]
ENSG00000257093	15.32	10.92	12.78	11.35	14.28	12.52	0.0533539928199234	4.15301709284998	0.714396307612832	0.923223982065295	7:141656727-141702153:-	KIAA1147	2;GO:0005737,cellular_component cytoplasm;GO:0051179,biological_process localization	NA	KIAA1147 [Source:HGNC Symbol%3BAcc:HGNC:29472]
ENSG00000134851	97.69	115.13	101.12	102.30	104.62	103.51	0.025436639579181	6.8004558973288	0.71445174991696	0.923223982065295	4:55395956-55453397:+	TMEM165	16;GO:0000139,cellular_component Golgi membrane;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006487,biological_process protein N-linked glycosylation;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0032472,biological_process Golgi calcium ion transport;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035751,biological_process regulation of lysosomal lumen pH;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	transmembrane protein 165 [Source:HGNC Symbol%3BAcc:HGNC:30760]
ENSG00000203880	15.93	17.09	16.00	15.72	14.74	17.63	0.0335662825507082	4.45698691019601	0.714827025038202	0.923552242648001	20:64255694-64287821:+	PCMTD2	5;GO:0004719,molecular_function protein-L-isoaspartate (D-aspartate) O-methyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0006479,biological_process protein methylation;GO:0032259,biological_process methylation	NA	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:15882]
ENSG00000151461	13.92	14.85	14.04	13.28	14.67	14.41	0.0244697316101519	5.76332589169824	0.714899088087358	0.923552242648001	10:11920021-12043170:-	UPF2	14;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001889,biological_process liver development;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0006406,biological_process mRNA export from nucleus;GO:0031100,biological_process organ regeneration;GO:0035145,cellular_component exon-exon junction complex;GO:0042162,molecular_function telomeric DNA binding;GO:0048471,cellular_component perinuclear region of cytoplasm	UPF2, RENT2; regulator of nonsense transcripts 2; K14327	UPF2%2C regulator of nonsense mediated mRNA decay [Source:HGNC Symbol%3BAcc:HGNC:17854]
ENSG00000174599	0.77	1.38	1.06	0.88	1.16	1.46	-0.153643344788375	0.465880723234112	0.714999862065518	0.923552242648001	4:117083553-117085576:-	TRAM1L1	6;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	translocation associated membrane protein 1-like 1 [Source:HGNC Symbol%3BAcc:HGNC:28371]
ENSG00000112877	4.33	5.47	3.56	4.44	3.59	4.78	0.0568183473966143	3.09864848388865	0.715114900077791	0.923552242648001	5:612271-667168:+	CEP72	15;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007051,biological_process spindle organization;GO:0007099,biological_process centriole replication;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0033566,biological_process gamma-tubulin complex localization;GO:0034451,cellular_component centriolar satellite;GO:0042802,molecular_function identical protein binding;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1904779,biological_process regulation of protein localization to centrosome	NA	centrosomal protein 72 [Source:HGNC Symbol%3BAcc:HGNC:25547]
ENSG00000168936	20.88	22.41	22.79	21.27	21.54	22.36	0.029196123087656	4.73568174559448	0.715119053676706	0.923552242648001	4:1715951-1721358:-	TMEM129	16;GO:0000209,biological_process protein polyubiquitination;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006986,biological_process response to unfolded protein;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway	NA	transmembrane protein 129 [Source:HGNC Symbol%3BAcc:HGNC:25137]
ENSG00000181896	5.67	5.33	5.29	6.18	5.86	5.05	-0.0524964779038171	2.89450911570876	0.715224165502623	0.923552242648001	19:19668795-19683509:+	ZNF101	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 101 [Source:HGNC Symbol%3BAcc:HGNC:12881]
ENSG00000170214	2.63	3.92	2.08	2.54	3.26	2.25	0.0907066848127099	2.14387381676871	0.715226593778719	0.923552242648001	5:159865079-159972544:+	ADRA1B	32;GO:0001994,biological_process norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004935,molecular_function adrenergic receptor activity;GO:0004937,molecular_function alpha1-adrenergic receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0006937,biological_process regulation of muscle contraction;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019229,biological_process regulation of vasoconstriction;GO:0031965,cellular_component nuclear membrane;GO:0035556,biological_process intracellular signal transduction;GO:0042593,biological_process glucose homeostasis;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046982,molecular_function protein heterodimerization activity;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0071880,biological_process adenylate cyclase-activating adrenergic receptor signaling pathway	ADRA1B; adrenergic receptor alpha-1B; K04136	adrenoceptor alpha 1B [Source:HGNC Symbol%3BAcc:HGNC:278]
ENSG00000114446	42.12	37.74	39.32	36.98	42.11	38.94	0.0287551840812132	5.78077174026769	0.715477111704655	0.923664104780953	3:108160811-108222570:-	IFT57	29;GO:0001843,biological_process neural tube closure;GO:0001947,biological_process heart looping;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007224,biological_process smoothened signaling pathway;GO:0030992,cellular_component intraciliary transport particle B;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0044292,cellular_component dendrite terminus;GO:0044458,biological_process motile cilium assembly;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060271,biological_process cilium morphogenesis;GO:0060972,biological_process left/right pattern formation;GO:0097542,cellular_component ciliary tip;GO:1905515,biological_process non-motile cilium assembly	IFT57, HIPPI, ESRRBL1; intraflagellar transport protein 57; K04638	intraflagellar transport 57 [Source:HGNC Symbol%3BAcc:HGNC:17367]
ENSG00000241404	7.15	5.76	7.03	8.77	5.44	6.96	-0.065114835938831	2.63514874090383	0.71560953822518	0.923664104780953	6:32164582-32168281:+	EGFL8	2;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region	NA	EGF like domain multiple 8 [Source:HGNC Symbol%3BAcc:HGNC:13944]
ENSG00000169967	11.33	10.65	12.68	12.30	12.21	11.40	-0.0327515369794228	4.46228895863339	0.715610271537683	0.923664104780953	2:127298729-127388465:-	MAP3K2	25;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0007257,biological_process activation of JUN kinase activity;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019901,molecular_function protein kinase binding;GO:0042981,biological_process regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0071260,biological_process cellular response to mechanical stimulus	NA	mitogen-activated protein kinase kinase kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6854]
ENSG00000165434	3.37	3.18	2.88	3.45	2.93	3.50	-0.0586962014077901	2.62450885272663	0.715610867290617	0.923664104780953	11:74330317-74398473:-	PGM2L1	14;GO:0004614,molecular_function phosphoglucomutase activity;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0005980,biological_process glycogen catabolic process;GO:0006006,biological_process glucose metabolic process;GO:0016740,molecular_function transferase activity;GO:0016853,molecular_function isomerase activity;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0019388,biological_process galactose catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047933,molecular_function glucose-1,6-bisphosphate synthase activity;GO:0061621,biological_process canonical glycolysis;GO:0071704,biological_process organic substance metabolic process	PGM2L1; glucose-1,6-bisphosphate synthase [EC:2.7.1.106]; K11809	phosphoglucomutase 2 like 1 [Source:HGNC Symbol%3BAcc:HGNC:20898]
ENSG00000036549	38.05	32.46	37.74	37.68	33.31	36.11	0.0295028803173157	6.62016439266741	0.715888079255412	0.923875805196776	1:77562415-77683419:-	ZZZ3	9;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger ZZ-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:24523]
ENSG00000172828	0.57	1.05	0.59	0.52	0.83	0.65	0.114705069543403	0.42643585743842	0.715978791493365	0.923875805196776	16:66961236-66975148:+	CES3	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005829,cellular_component cytosol;GO:0006805,biological_process xenobiotic metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	carboxylesterase 3 [Source:HGNC Symbol%3BAcc:HGNC:1865]
ENSG00000167705	3.46	3.10	2.69	3.30	2.46	3.04	0.0843567095095871	1.91627303062781	0.716104025043204	0.923875805196776	17:1646144-1650077:-	RILP	28;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008333,biological_process endosome to lysosome transport;GO:0010796,biological_process regulation of multivesicular body size;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031267,molecular_function small GTPase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0032509,biological_process endosome transport via multivesicular body sorting pathway;GO:0036064,cellular_component ciliary basal body;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0043234,cellular_component protein complex;GO:0045022,biological_process early endosome to late endosome transport;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046983,molecular_function protein dimerization activity;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0070676,biological_process intralumenal vesicle formation	RILP; Rab-interacting lysosomal protein; K13883	Rab interacting lysosomal protein [Source:HGNC Symbol%3BAcc:HGNC:30266]
ENSG00000107938	6.07	5.47	6.76	6.13	6.30	6.51	-0.0312570103592098	4.68421164341129	0.71616919642277	0.923875805196776	10:125719514-125764143:+	EDRF1	5;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	erythroid differentiation regulatory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:24640]
ENSG00000105323	120.06	125.66	119.55	126.86	125.82	121.14	-0.022011029990142	8.36838213527501	0.716189484529629	0.923875805196776	19:41262495-41307598:+	HNRNPUL1	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0009615,biological_process response to virus;GO:0019013,cellular_component viral nucleocapsid;GO:0019899,molecular_function enzyme binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex	HNRNPUL1, E1BAP5; heterogeneous nuclear ribonucleoprotein U-like protein 1; K15047	heterogeneous nuclear ribonucleoprotein U like 1 [Source:HGNC Symbol%3BAcc:HGNC:17011]
ENSG00000104524	5.89	6.06	5.65	5.33	6.16	5.48	0.062605213415149	2.41210100268852	0.716221451172849	0.923875805196776	8:143603912-143609773:-	PYCR3	10;GO:0004735,molecular_function pyrroline-5-carboxylate reductase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006561,biological_process proline biosynthetic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0042802,molecular_function identical protein binding;GO:0055114,biological_process oxidation-reduction process;GO:0055129,biological_process L-proline biosynthetic process	proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]; K00286	pyrroline-5-carboxylate reductase 3 [Source:HGNC Symbol%3BAcc:HGNC:25846]
ENSG00000148926	266.38	187.15	261.28	261.30	201.49	281.98	-0.0463099350187404	7.19409734564511	0.716342063468921	0.923935373424743	11:10304679-10307397:+	ADM	54;GO:0001570,biological_process vasculogenesis;GO:0001666,biological_process response to hypoxia;GO:0001843,biological_process neural tube closure;GO:0002026,biological_process regulation of the force of heart contraction;GO:0002031,biological_process G-protein coupled receptor internalization;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0005102,molecular_function receptor binding;GO:0005179,molecular_function hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006171,biological_process cAMP biosynthetic process;GO:0006701,biological_process progesterone biosynthetic process;GO:0007165,biological_process signal transduction;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007267,biological_process cell-cell signaling;GO:0007507,biological_process heart development;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0008015,biological_process blood circulation;GO:0008209,biological_process androgen metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009409,biological_process response to cold;GO:0009611,biological_process response to wounding;GO:0010033,biological_process response to organic substance;GO:0010460,biological_process positive regulation of heart rate;GO:0019933,biological_process cAMP-mediated signaling;GO:0030816,biological_process positive regulation of cAMP metabolic process;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031100,biological_process organ regeneration;GO:0031102,biological_process neuron projection regeneration;GO:0031623,biological_process receptor internalization;GO:0031700,molecular_function adrenomedullin receptor binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0032868,biological_process response to insulin;GO:0035809,biological_process regulation of urine volume;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042594,biological_process response to starvation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043116,biological_process negative regulation of vascular permeability;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045906,biological_process negative regulation of vasoconstriction;GO:0046879,biological_process hormone secretion;GO:0048589,biological_process developmental growth;GO:0051384,biological_process response to glucocorticoid;GO:0055074,biological_process calcium ion homeostasis;GO:0060670,biological_process branching involved in labyrinthine layer morphogenesis;GO:0060712,biological_process spongiotrophoblast layer development;GO:0097084,biological_process vascular smooth muscle cell development;GO:0097647,biological_process amylin receptor signaling pathway;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:2001214,biological_process positive regulation of vasculogenesis	ADM; adrenomedullin; K12333	adrenomedullin [Source:HGNC Symbol%3BAcc:HGNC:259]
ENSG00000151779	14.47	14.11	14.63	14.85	14.43	15.01	-0.0226122391008668	6.71598733266356	0.716443887862626	0.923970699224809	2:15166908-15561330:-	NBAS	13;GO:0000149,molecular_function SNARE binding;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070939,cellular_component Dsl1p complex;GO:2000623,biological_process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	NA	neuroblastoma amplified sequence [Source:HGNC Symbol%3BAcc:HGNC:15625]
ENSG00000180340	10.58	10.54	9.55	8.22	11.41	10.33	0.0446956726946023	4.11058307116828	0.716618389479975	0.92401089873809	17:44557458-44559570:+	FZD2	38;GO:0003149,biological_process membranous septum morphogenesis;GO:0003150,biological_process muscular septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007608,biological_process sensory perception of smell;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0017147,molecular_function Wnt-protein binding;GO:0030165,molecular_function PDZ domain binding;GO:0030182,biological_process neuron differentiation;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0030825,biological_process positive regulation of cGMP metabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0035567,biological_process non-canonical Wnt signaling pathway;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060022,biological_process hard palate development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060119,biological_process inner ear receptor cell development;GO:0060412,biological_process ventricular septum morphogenesis;GO:0090103,biological_process cochlea morphogenesis;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:1904886,biological_process beta-catenin destruction complex disassembly	FZD2; frizzled 2; K02235	frizzled class receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:4040]
ENSG00000111832	59.00	62.92	60.78	59.67	60.86	60.29	0.0241388195070764	5.46974395403242	0.716623936369257	0.92401089873809	6:116571366-116597675:+	RWDD1	9;GO:0002181,biological_process cytoplasmic translation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0007569,biological_process cell aging;GO:0030521,biological_process androgen receptor signaling pathway;GO:0034599,biological_process cellular response to oxidative stress;GO:0071394,biological_process cellular response to testosterone stimulus;GO:2000825,biological_process positive regulation of androgen receptor activity	NA	RWD domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20993]
ENSG00000171503	6.60	6.92	6.60	6.59	6.92	6.15	0.0425037715153733	3.63373518227483	0.716920281258975	0.924296993276658	4:158672124-158709623:+	ETFDH	23;GO:0004174,molecular_function electron-transferring-flavoprotein dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006979,biological_process response to oxidative stress;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0017133,cellular_component mitochondrial electron transfer flavoprotein complex;GO:0022900,biological_process electron transport chain;GO:0022904,biological_process respiratory electron transport chain;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0043783,molecular_function oxidoreductase activity, oxidizing metal ions with flavin as acceptor;GO:0046872,molecular_function metal ion binding;GO:0048038,molecular_function quinone binding;GO:0048039,molecular_function ubiquinone binding;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process	NA	electron transfer flavoprotein dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:3483]
ENSG00000137161	72.83	77.92	69.28	74.78	77.30	73.44	-0.0266680799329345	5.95585773220396	0.717039728483972	0.924354984907212	6:42929191-42939287:+	CNPY3	6;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0005102,molecular_function receptor binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0045087,biological_process innate immune response	NA	canopy FGF signaling regulator 3 [Source:HGNC Symbol%3BAcc:HGNC:11968]
ENSG00000197603	6.27	6.79	6.92	7.00	6.47	6.31	0.0258144652729877	6.02400029655101	0.717401662077178	0.924572603350261	5:37106227-37249428:-	C5orf42	17;GO:0001736,biological_process establishment of planar polarity;GO:0001822,biological_process kidney development;GO:0003279,biological_process cardiac septum development;GO:0003281,biological_process ventricular septum development;GO:0005929,cellular_component cilium;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021549,biological_process cerebellum development;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0060021,biological_process palate development;GO:0060271,biological_process cilium morphogenesis;GO:0060976,biological_process coronary vasculature development;GO:1904491,biological_process protein localization to ciliary transition zone	NA	chromosome 5 open reading frame 42 [Source:HGNC Symbol%3BAcc:HGNC:25801]
ENSG00000197599	1.46	1.32	1.20	1.33	1.23	1.70	-0.0899527856862932	1.56071837667976	0.717545843828121	0.924572603350261	16:1434382-1444556:-	CCDC154	2;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome	NA	coiled-coil domain containing 154 [Source:HGNC Symbol%3BAcc:HGNC:34454]
ENSG00000114098	18.85	16.83	17.57	19.32	17.10	18.41	-0.0271398606971187	5.26609264266461	0.717571066657369	0.924572603350261	3:138187247-138298389:+	ARMC8	5;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:1904724,cellular_component tertiary granule lumen	NA	armadillo repeat containing 8 [Source:HGNC Symbol%3BAcc:HGNC:24999]
ENSG00000111961	6.93	6.94	7.76	7.06	7.69	7.53	-0.0292364640674528	4.96472607741542	0.717817913928309	0.924572603350261	6:148272303-148552050:+	SASH1	14;GO:0000209,biological_process protein polyubiquitination;GO:0008022,molecular_function protein C-terminus binding;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0019901,molecular_function protein kinase binding;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0031666,biological_process positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032947,molecular_function protein complex scaffold;GO:0043234,cellular_component protein complex;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045766,biological_process positive regulation of angiogenesis;GO:1900044,biological_process regulation of protein K63-linked ubiquitination;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1902498,biological_process regulation of protein autoubiquitination	NA	SAM and SH3 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19182]
ENSG00000147650	41.41	38.83	43.87	40.50	37.64	44.67	0.027955520892193	6.73246482932487	0.717902422680017	0.924572603350261	8:104489230-104589024:-	LRP12	12;GO:0001764,biological_process neuron migration;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005515,molecular_function protein binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031175,biological_process neuron projection development;GO:0040008,biological_process regulation of growth	NA	LDL receptor related protein 12 [Source:HGNC Symbol%3BAcc:HGNC:31708]
ENSG00000078246	39.44	38.04	37.00	37.92	39.80	39.62	-0.0234507403682803	5.98402282792274	0.718029729624574	0.924572603350261	12:2877222-2941140:+	TULP3	41;GO:0001841,biological_process neural tube formation;GO:0001843,biological_process neural tube closure;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016020,cellular_component membrane;GO:0019899,molecular_function enzyme binding;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021914,biological_process negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning;GO:0021915,biological_process neural tube development;GO:0021953,biological_process central nervous system neuron differentiation;GO:0030991,cellular_component intraciliary transport particle A;GO:0031076,biological_process embryonic camera-type eye development;GO:0032403,molecular_function protein complex binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0048702,biological_process embryonic neurocranium morphogenesis;GO:0060173,biological_process limb development;GO:0060348,biological_process bone development;GO:0060434,biological_process bronchus morphogenesis;GO:0060831,biological_process smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0061548,biological_process ganglion development;GO:0097500,biological_process receptor localization to nonmotile primary cilium;GO:0097546,cellular_component ciliary base;GO:1901621,biological_process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:1903546,biological_process protein localization to photoreceptor outer segment	NA	tubby like protein 3 [Source:HGNC Symbol%3BAcc:HGNC:12425]
ENSG00000145246	10.73	11.60	11.23	10.85	11.80	10.53	0.0261638027995134	5.58153786204775	0.718034367294869	0.924572603350261	4:47485287-47593486:+	ATP10D	19;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004012,molecular_function phospholipid-translocating ATPase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006812,biological_process cation transport;GO:0006869,biological_process lipid transport;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0034220,biological_process ion transmembrane transport;GO:0045332,biological_process phospholipid translocation;GO:0046872,molecular_function metal ion binding	NA	ATPase phospholipid transporting 10D (putative) [Source:HGNC Symbol%3BAcc:HGNC:13549]
ENSG00000033030	18.39	16.87	19.47	18.47	19.14	18.74	-0.0254364180245326	5.30570195446088	0.71807002830067	0.924572603350261	12:122471599-122501073:-	ZCCHC8	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0046872,molecular_function metal ion binding;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	zinc finger CCHC-type containing 8 [Source:HGNC Symbol%3BAcc:HGNC:25265]
ENSG00000150403	54.72	59.11	52.67	54.81	53.01	57.12	0.023685539006089	6.96917058840151	0.718145210385369	0.924572603350261	13:113490994-113554590:+	TMCO3	11;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022890,molecular_function inorganic cation transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:0098655,biological_process cation transmembrane transport;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	transmembrane and coiled-coil domains 3 [Source:HGNC Symbol%3BAcc:HGNC:20329]
ENSG00000164687	147.70	141.34	160.11	152.70	141.39	151.05	0.0268449865102289	5.92115772996347	0.718242139528072	0.924572603350261	8:81280362-81284777:+	FABP5	20;GO:0005215,molecular_function transporter activity;GO:0005504,molecular_function fatty acid binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006006,biological_process glucose metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0008544,biological_process epidermis development;GO:0015758,biological_process glucose transport;GO:0019433,biological_process triglyceride catabolic process;GO:0030667,cellular_component secretory granule membrane;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	FABP5; fatty acid-binding protein 5, epidermal; K08754	fatty acid binding protein 5 [Source:HGNC Symbol%3BAcc:HGNC:3560]
ENSG00000198498	23.19	20.63	22.21	26.00	20.01	22.64	-0.0402975276901241	4.16810274907135	0.718356527261414	0.924572603350261	4:163494441-163520539:+	TMA16	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005840,cellular_component ribosome	NA	translation machinery associated 16 homolog [Source:HGNC Symbol%3BAcc:HGNC:25638]
ENSG00000232070	1.19	1.61	0.90	0.69	1.63	0.86	0.205978539284131	-0.172779970902058	0.718627752865412	0.924572603350261	14:21098936-21103724:+	TMEM253	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 253 [Source:HGNC Symbol%3BAcc:HGNC:32545]
ENSG00000132330	6.36	7.31	7.59	7.23	6.68	8.14	-0.046149049563679	3.85837408824632	0.718641463480306	0.924572603350261	2:238060888-238099413:+	SCLY	14;GO:0001887,biological_process selenium compound metabolic process;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0009000,molecular_function selenocysteine lyase activity;GO:0016261,biological_process selenocysteine catabolic process;GO:0016597,molecular_function amino acid binding;GO:0016740,molecular_function transferase activity;GO:0016829,molecular_function lyase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0070279,molecular_function vitamin B6 binding;GO:1902494,cellular_component catalytic complex	SCLY; selenocysteine lyase [EC:4.4.1.16]; K01763	selenocysteine lyase [Source:HGNC Symbol%3BAcc:HGNC:18161]
ENSG00000162927	4.59	4.58	3.93	4.68	4.19	3.80	0.0583176454939164	2.85059801342189	0.718658122914258	0.924572603350261	2:60940221-61018259:-	PUS10	7;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity;GO:0031119,biological_process tRNA pseudouridine synthesis	NA	pseudouridylate synthase 10 [Source:HGNC Symbol%3BAcc:HGNC:26505]
ENSG00000162757	6.30	4.74	4.47	5.94	5.83	4.79	-0.0698607490394596	2.16413227022214	0.718662078557187	0.924572603350261	1:209779207-209784559:-	C1orf74	NA	NA	chromosome 1 open reading frame 74 [Source:HGNC Symbol%3BAcc:HGNC:26319]
ENSG00000198417	12.46	6.05	5.00	4.07	10.30	12.41	-0.161779680032532	1.02626873289123	0.718664892113799	0.924572603350261	16:56657693-56660698:+	MT1F	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0045926,biological_process negative regulation of growth;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071276,biological_process cellular response to cadmium ion;GO:0071294,biological_process cellular response to zinc ion	MT1_2; metallothionein 1/2; K14739	metallothionein 1F [Source:HGNC Symbol%3BAcc:HGNC:7398]
ENSG00000165480	8.24	9.36	7.27	7.80	7.90	10.23	-0.0592720155012077	3.46273933814697	0.718800602532264	0.924572603350261	13:21153594-21176602:-	SKA3	16;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000940,cellular_component condensed chromosome outer kinetochore;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0031110,biological_process regulation of microtubule polymerization or depolymerization;GO:0051301,biological_process cell division	NA	spindle and kinetochore associated complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:20262]
ENSG00000204178	16.81	16.41	17.48	16.05	16.49	17.61	0.0282001924519326	5.07341388518862	0.719055244766214	0.924572603350261	1:25430857-25500209:+	TMEM57	12;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0007420,biological_process brain development;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030424,cellular_component axon;GO:0031965,cellular_component nuclear membrane;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0044306,cellular_component neuron projection terminus;GO:0045202,cellular_component synapse	NA	transmembrane protein 57 [Source:HGNC Symbol%3BAcc:HGNC:25572]
ENSG00000173852	31.83	34.93	30.83	29.30	34.87	32.24	0.0271530784468341	6.23330114170902	0.719081324378143	0.924572603350261	7:34928875-35038271:-	DPY19L1	7;GO:0000030,molecular_function mannosyltransferase activity;GO:0005637,cellular_component nuclear inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018406,biological_process protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	NA	dpy-19 like 1 [Source:HGNC Symbol%3BAcc:HGNC:22205]
ENSG00000142875	14.95	14.97	18.43	16.28	14.86	16.40	0.0389296660108262	4.49436628718663	0.719098922982497	0.924572603350261	1:84078061-84238498:+	PRKACB	37;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001843,biological_process neural tube closure;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003091,biological_process renal water homeostasis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004691,molecular_function cAMP-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005952,cellular_component cAMP-dependent protein kinase complex;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034199,biological_process activation of protein kinase A activity;GO:0034380,biological_process high-density lipoprotein particle assembly;GO:0045171,cellular_component intercellular bridge;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051447,biological_process negative regulation of meiotic cell cycle;GO:0070062,cellular_component extracellular exosome;GO:0070613,biological_process regulation of protein processing;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0097338,biological_process response to clozapine;GO:0097546,cellular_component ciliary base;GO:1901621,biological_process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	PKA; protein kinase A [EC:2.7.11.11]; K04345	protein kinase cAMP-activated catalytic subunit beta [Source:HGNC Symbol%3BAcc:HGNC:9381]
ENSG00000173681	9.77	7.04	8.51	9.19	9.51	7.72	-0.0396847133433779	4.28987639220799	0.719132759813172	0.924572603350261	X:19912859-19970298:-	BCLAF3	1;GO:0005739,cellular_component mitochondrion	NA	BCLAF1 and THRAP3 family member 3 [Source:HGNC Symbol%3BAcc:HGNC:27413]
ENSG00000107669	6.55	7.03	7.16	6.06	6.52	7.68	0.0413980825349542	3.61303322383472	0.719273190814696	0.924572603350261	10:121740420-121928801:-	ATE1	8;GO:0004057,molecular_function arginyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0010498,biological_process proteasomal protein catabolic process;GO:0016598,biological_process protein arginylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups	NA	arginyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:782]
ENSG00000132357	2.52	2.63	2.21	2.04	2.92	2.15	0.0585626814970845	2.97031209045626	0.719290967142505	0.924572603350261	5:40841183-40860175:+	CARD6	2;GO:0006915,biological_process apoptotic process;GO:0042981,biological_process regulation of apoptotic process	CARD6; caspase recruitment domain-containing protein 6; K12797	caspase recruitment domain family member 6 [Source:HGNC Symbol%3BAcc:HGNC:16394]
ENSG00000197037	6.65	6.37	7.47	6.68	5.42	7.78	0.0554785146008467	3.4849931955187	0.71932148446625	0.924572603350261	7:99616945-99632407:+	ZSCAN25	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 25 [Source:HGNC Symbol%3BAcc:HGNC:21961]
ENSG00000178502	2.43	2.34	2.95	2.33	2.93	2.91	-0.0650763229784975	2.53539301074875	0.719370854988616	0.924572603350261	17:41853544-41865431:-	KLHL11	9;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	kelch like family member 11 [Source:HGNC Symbol%3BAcc:HGNC:19008]
ENSG00000203950	83.75	72.17	91.62	87.90	86.80	81.52	-0.0303740250026569	4.8431061191174	0.719379679913042	0.924572603350261	X:135050931-135052196:-	RTL8A	1;GO:0005515,molecular_function protein binding	NA	retrotransposon Gag like 8A [Source:HGNC Symbol%3BAcc:HGNC:24514]
ENSG00000142733	7.10	6.21	6.69	5.90	7.28	6.53	0.0376283683164536	4.7040494733617	0.719404432096333	0.924572603350261	1:27355183-27366892:-	MAP3K6	15;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007257,biological_process activation of JUN kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]; K04425	mitogen-activated protein kinase kinase kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:6858]
ENSG00000145088	1.44	1.95	1.24	1.62	1.91	1.52	-0.138451075278727	0.568292211737796	0.719451211485984	0.924572603350261	3:121835182-121886526:+	EAF2	17;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0008023,cellular_component transcription elongation factor complex;GO:0016607,cellular_component nuclear speck;GO:0030308,biological_process negative regulation of cell growth;GO:0032783,cellular_component ELL-EAF complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060770,biological_process negative regulation of epithelial cell proliferation involved in prostate gland development	NA	ELL associated factor 2 [Source:HGNC Symbol%3BAcc:HGNC:23115]
ENSG00000146776	1.70	1.74	1.72	1.77	1.85	1.80	-0.0608409687741778	2.50141044269323	0.719528439525439	0.924572603350261	7:105605066-105876604:-	ATXN7L1	1;GO:0005515,molecular_function protein binding	NA	ataxin 7 like 1 [Source:HGNC Symbol%3BAcc:HGNC:22210]
ENSG00000146587	8.18	8.03	8.59	8.07	7.68	8.63	0.0362484695271693	4.14871567135556	0.719552495982238	0.924572603350261	7:5045820-5069488:+	RBAK	9;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	RB associated KRAB zinc finger [Source:HGNC Symbol%3BAcc:HGNC:17680]
ENSG00000126814	16.73	13.77	14.43	14.59	13.72	15.96	0.0375924242009321	4.68404276754656	0.719580925225856	0.924572603350261	14:60971450-60981358:-	TRMT5	12;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0009019,molecular_function tRNA (guanine-N1-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0052906,molecular_function tRNA (guanine(37)-N(1))-methyltransferase activity;GO:0070901,biological_process mitochondrial tRNA methylation	NA	tRNA methyltransferase 5 [Source:HGNC Symbol%3BAcc:HGNC:23141]
ENSG00000106028	233.35	245.37	216.33	236.76	242.22	233.44	-0.0254839398201699	6.70488045680969	0.719635929395299	0.924572603350261	7:141738320-141787922:+	SSBP1	14;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006260,biological_process DNA replication;GO:0007005,biological_process mitochondrion organization;GO:0042645,cellular_component mitochondrial nucleoid;GO:0051096,biological_process positive regulation of helicase activity;GO:0070062,cellular_component extracellular exosome;GO:0070584,biological_process mitochondrion morphogenesis	ssb; single-strand DNA-binding protein; K03111	single stranded DNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11317]
ENSG00000213221	6.61	8.05	7.03	6.31	8.10	6.32	0.068040394839589	1.96535649320647	0.719691995836207	0.924572603350261	9:136359479-136363789:-	DNLZ	8;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006457,biological_process protein folding;GO:0008270,molecular_function zinc ion binding;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0051087,molecular_function chaperone binding	NA	DNL-type zinc finger [Source:HGNC Symbol%3BAcc:HGNC:33879]
ENSG00000109911	15.07	15.64	13.75	15.42	15.65	14.59	-0.0295446223642067	5.26676590857865	0.719774208002495	0.924572603350261	11:31509699-31790328:+	ELP4	17;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000993,molecular_function RNA polymerase II core binding;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008023,cellular_component transcription elongation factor complex;GO:0008607,molecular_function phosphorylase kinase regulator activity;GO:0033588,cellular_component Elongator holoenzyme complex;GO:0043966,biological_process histone H3 acetylation;GO:0043967,biological_process histone H4 acetylation;GO:0045859,biological_process regulation of protein kinase activity	NA	elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:1171]
ENSG00000167862	34.01	38.82	35.99	38.82	34.84	38.33	-0.0360935688504962	4.6465742080582	0.719850302552927	0.924572603350261	17:75012669-75021261:+	MRPL58	15;GO:0003747,molecular_function translation release factor activity;GO:0004045,molecular_function aminoacyl-tRNA hydrolase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0006415,biological_process translational termination;GO:0016150,molecular_function translation release factor activity, codon nonspecific;GO:0016787,molecular_function hydrolase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination;GO:0072344,biological_process rescue of stalled ribosome	NA	mitochondrial ribosomal protein L58 [Source:HGNC Symbol%3BAcc:HGNC:5359]
ENSG00000112159	6.14	6.17	6.16	5.93	6.54	6.47	-0.0237775815955189	6.71321904397127	0.719947321018353	0.924572603350261	6:89642498-89819723:-	MDN1	14;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006461,biological_process protein complex assembly;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051082,molecular_function unfolded protein binding	MDN1, REA1; midasin; K14572	midasin AAA ATPase 1 [Source:HGNC Symbol%3BAcc:HGNC:18302]
ENSG00000128581	57.61	61.16	55.64	55.71	60.57	55.92	0.027013016102784	5.08662928018843	0.720052501554324	0.924572603350261	7:101313366-101321823:-	IFT22	9;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005813,cellular_component centrosome;GO:0005929,cellular_component cilium;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0030992,cellular_component intraciliary transport particle B;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0097542,cellular_component ciliary tip	NA	intraflagellar transport 22 [Source:HGNC Symbol%3BAcc:HGNC:21895]
ENSG00000160325	6.53	7.01	6.60	4.58	7.52	7.17	0.0704184860169965	2.31597367900232	0.720155458514138	0.924572603350261	9:133459964-133470848:+	CACFD1	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport	NA	calcium channel flower domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:1365]
ENSG00000019995	15.76	14.53	16.36	16.71	13.35	15.92	0.0349203540541119	5.04484529543244	0.72024272936848	0.924572603350261	10:124942122-124988189:+	ZRANB1	24;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0007010,biological_process cytoskeleton organization;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016055,biological_process Wnt signaling pathway;GO:0016477,biological_process cell migration;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0035523,biological_process protein K29-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071947,biological_process protein deubiquitination involved in ubiquitin-dependent protein catabolic process;GO:1990168,biological_process protein K33-linked deubiquitination	NA	zinc finger RANBP2-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18224]
ENSG00000165283	93.54	93.96	87.69	87.75	90.36	94.75	0.0231840691312186	6.69737007386129	0.720299366108476	0.924572603350261	9:35099775-35103195:-	STOML2	32;GO:0001772,cellular_component immunological synapse;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007005,biological_process mitochondrion organization;GO:0008180,cellular_component COP9 signalosome;GO:0008289,molecular_function lipid binding;GO:0010876,biological_process lipid localization;GO:0010918,biological_process positive regulation of mitochondrial membrane potential;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0032623,biological_process interleukin-2 production;GO:0034982,biological_process mitochondrial protein processing;GO:0035710,biological_process CD4-positive, alpha-beta T cell activation;GO:0042101,cellular_component T cell receptor complex;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045121,cellular_component membrane raft;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051020,molecular_function GTPase binding;GO:0051259,biological_process protein oligomerization;GO:0090297,biological_process positive regulation of mitochondrial DNA replication;GO:1900210,biological_process positive regulation of cardiolipin metabolic process;GO:1901612,molecular_function cardiolipin binding;GO:1990046,biological_process stress-induced mitochondrial fusion	NA	stomatin like 2 [Source:HGNC Symbol%3BAcc:HGNC:14559]
ENSG00000165959	8.60	8.37	9.11	9.12	8.45	9.29	-0.0294525362141424	4.78183671133752	0.720316945827741	0.924572603350261	14:95181939-95319906:-	CLMN	6;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031175,biological_process neuron projection development	NA	calmin [Source:HGNC Symbol%3BAcc:HGNC:19972]
ENSG00000102898	200.20	226.00	218.10	209.09	221.36	207.45	0.0242060144548851	6.34983230644053	0.720445591483955	0.924572603350261	16:67846731-67872567:+	NUTF2	24;GO:0000060,biological_process protein import into nucleus, translocation;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005640,cellular_component nuclear outer membrane;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0031965,cellular_component nuclear membrane;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0044613,cellular_component nuclear pore central transport channel;GO:0051028,biological_process mRNA transport;GO:0070062,cellular_component extracellular exosome;GO:0090204,biological_process protein localization to nuclear pore;GO:1904046,biological_process negative regulation of vascular endothelial growth factor production	NA	nuclear transport factor 2 [Source:HGNC Symbol%3BAcc:HGNC:13722]
ENSG00000127423	7.13	6.38	8.08	8.09	6.99	7.53	-0.0458557867737252	3.10080710963415	0.720525574302032	0.924572603350261	1:25831912-25859458:-	AUNIP	7;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007051,biological_process spindle organization	NA	aurora kinase A and ninein interacting protein [Source:HGNC Symbol%3BAcc:HGNC:28363]
ENSG00000166819	1.19	1.38	1.37	1.35	1.05	1.27	0.105877757907889	1.17331220127566	0.720526245442209	0.924572603350261	15:89664364-89679427:-	PLIN1	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process	PLIN1; perilipin-1; K08768	perilipin 1 [Source:HGNC Symbol%3BAcc:HGNC:9076]
ENSG00000127054	30.68	28.45	30.66	29.50	26.42	32.86	0.0288913891317969	6.23539146166179	0.720560329075197	0.924572603350261	1:1311584-1324691:-	INTS11	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016180,biological_process snRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0072562,cellular_component blood microparticle	NA	integrator complex subunit 11 [Source:HGNC Symbol%3BAcc:HGNC:26052]
ENSG00000184857	16.91	17.05	18.08	20.15	16.97	16.95	-0.0415835773043804	3.51900810655371	0.720804202410534	0.924747952771918	16:8780383-8797648:-	TMEM186	3;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 186 [Source:HGNC Symbol%3BAcc:HGNC:24530]
ENSG00000165512	28.17	22.04	29.13	27.63	26.52	28.46	-0.0359311726815377	4.20067137776131	0.720845983325633	0.924747952771918	10:45000474-45005326:+	ZNF22	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0042476,biological_process odontogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 22 [Source:HGNC Symbol%3BAcc:HGNC:13012]
ENSG00000143801	5.78	5.70	5.87	6.17	5.20	6.72	-0.0523491035983569	3.12040766963094	0.721039933213051	0.92490117711828	1:226870183-226896105:+	PSEN2	47;GO:0000139,cellular_component Golgi membrane;GO:0000776,cellular_component kinetochore;GO:0001666,biological_process response to hypoxia;GO:0004175,molecular_function endopeptidase activity;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005637,cellular_component nuclear inner membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0006816,biological_process calcium ion transport;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0008233,molecular_function peptidase activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0030018,cellular_component Z disc;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0031594,cellular_component neuromuscular junction;GO:0035253,cellular_component ciliary rootlet;GO:0035556,biological_process intracellular signal transduction;GO:0042500,molecular_function aspartic endopeptidase activity, intramembrane cleaving;GO:0042987,biological_process amyloid precursor protein catabolic process;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043198,cellular_component dendritic shaft;GO:0043234,cellular_component protein complex;GO:0045121,cellular_component membrane raft;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050435,biological_process beta-amyloid metabolic process	PSEN2, PS2; presenilin 2 [EC:3.4.23.-]; K04522	presenilin 2 [Source:HGNC Symbol%3BAcc:HGNC:9509]
ENSG00000169744	1.30	0.67	0.73	0.69	0.75	1.04	0.15611952295761	0.477597020963672	0.721221552726415	0.925038554865983	4:16501540-16898809:-	LDB2	18;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001942,biological_process hair follicle development;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0010669,biological_process epithelial structure maintenance;GO:0019899,molecular_function enzyme binding;GO:0030274,molecular_function LIM domain binding;GO:0030334,biological_process regulation of cell migration;GO:0031252,cellular_component cell leading edge;GO:0035019,biological_process somatic stem cell population maintenance;GO:0043549,biological_process regulation of kinase activity;GO:0044089,biological_process positive regulation of cellular component biogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	LIM domain binding 2 [Source:HGNC Symbol%3BAcc:HGNC:6533]
ENSG00000176087	32.80	34.99	32.18	32.50	36.29	33.81	-0.0285874431086651	5.43936036499159	0.721386059676285	0.925099772565242	5:140564455-140569103:+	SLC35A4	9;GO:0000139,cellular_component Golgi membrane;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032056,biological_process positive regulation of translation in response to stress	NA	solute carrier family 35 member A4 [Source:HGNC Symbol%3BAcc:HGNC:20753]
ENSG00000055208	50.44	47.24	50.57	50.63	48.73	52.62	-0.0228757010837204	6.7230845361994	0.72141833548953	0.925099772565242	6:149218640-149411613:+	TAB2	22;GO:0000187,biological_process activation of MAPK activity;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0007507,biological_process heart development;GO:0010008,cellular_component endosome membrane;GO:0010507,biological_process negative regulation of autophagy;GO:0016020,cellular_component membrane;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070530,molecular_function K63-linked polyubiquitin binding	MAP3K7IP2, TAB2; TAK1-binding protein 2; K04404	TGF-beta activated kinase 1/MAP3K7 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17075]
ENSG00000124486	28.52	28.31	27.84	27.21	28.16	28.74	0.0211151944685875	7.76264283026594	0.721512420464646	0.9251248502456	X:41085634-41236579:+	USP9X	26;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001764,biological_process neuron migration;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007292,biological_process female gamete generation;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030426,cellular_component growth cone;GO:0030509,biological_process BMP signaling pathway;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042995,cellular_component cell projection;GO:0044267,biological_process cellular protein metabolic process;GO:0048675,biological_process axon extension;GO:0051301,biological_process cell division;GO:0070410,molecular_function co-SMAD binding	NA	ubiquitin specific peptidase 9%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:12632]
ENSG00000139613	36.85	36.72	37.13	37.03	38.80	37.48	-0.02178750412176	7.12611248031098	0.721730557489988	0.925264172352863	12:56162982-56189567:-	SMARCC2	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006337,biological_process nucleosome disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007399,biological_process nervous system development;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0017053,cellular_component transcriptional repressor complex;GO:0021882,biological_process regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment;GO:0031492,molecular_function nucleosomal DNA binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0071564,cellular_component npBAF complex;GO:0071565,cellular_component nBAF complex;GO:0090544,cellular_component BAF-type complex	SMARCC; SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C; K11649	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin subfamily c member 2 [Source:HGNC Symbol%3BAcc:HGNC:11105]
ENSG00000241852	2.56	2.91	2.71	2.81	2.35	2.68	0.0619582820763566	2.09448178645874	0.721808757379553	0.925264172352863	8:22599600-22604150:+	C8orf58	NA	NA	chromosome 8 open reading frame 58 [Source:HGNC Symbol%3BAcc:HGNC:32233]
ENSG00000177200	7.03	7.00	7.85	7.53	7.55	7.38	-0.024138133194926	6.02021922352602	0.721920465349296	0.925264172352863	16:53055032-53329150:+	CHD9	13;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016787,molecular_function hydrolase activity;GO:0016817,molecular_function hydrolase activity, acting on acid anhydrides;GO:0019216,biological_process regulation of lipid metabolic process	NA	chromodomain helicase DNA binding protein 9 [Source:HGNC Symbol%3BAcc:HGNC:25701]
ENSG00000132406	35.18	32.35	35.10	38.73	33.25	34.35	-0.0347178933031741	4.19380723080301	0.722006322245115	0.925264172352863	4:4235541-4248212:-	TMEM128	6;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 128 [Source:HGNC Symbol%3BAcc:HGNC:28201]
ENSG00000128708	63.66	64.39	62.12	62.54	61.42	64.72	0.0220855063077422	6.31400466885506	0.722035492382062	0.925264172352863	2:171922447-171983682:+	HAT1	23;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000790,cellular_component nuclear chromatin;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006323,biological_process DNA packaging;GO:0006325,biological_process chromatin organization;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006348,biological_process chromatin silencing at telomere;GO:0006475,biological_process internal protein amino acid acetylation;GO:0007584,biological_process response to nutrient;GO:0010485,molecular_function H4 histone acetyltransferase activity;GO:0016363,cellular_component nuclear matrix;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0042393,molecular_function histone binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043967,biological_process histone H4 acetylation	HAT1, KAT1; histone acetyltransferase 1 [EC:2.3.1.48]; K11303	histone acetyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:4821]
ENSG00000119013	137.65	173.25	132.93	138.54	156.07	141.11	0.0326124299448487	5.43088581788178	0.722068318503358	0.925264172352863	2:201071432-201085750:+	NDUFB3	12;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022900,biological_process electron transport chain;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070469,cellular_component respiratory chain	NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3; K03959	NADH:ubiquinone oxidoreductase subunit B3 [Source:HGNC Symbol%3BAcc:HGNC:7698]
ENSG00000091542	44.99	45.92	44.09	44.59	44.98	48.78	-0.0255785762076897	5.75577527216297	0.722144919696346	0.925266813397062	17:18183077-18209954:+	ALKBH5	19;GO:0001666,biological_process response to hypoxia;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0007283,biological_process spermatogenesis;GO:0016491,molecular_function oxidoreductase activity;GO:0016607,cellular_component nuclear speck;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0030154,biological_process cell differentiation;GO:0035515,molecular_function oxidative RNA demethylase activity;GO:0035553,biological_process oxidative single-stranded RNA demethylation;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	alkB homolog 5%2C RNA demethylase [Source:HGNC Symbol%3BAcc:HGNC:25996]
ENSG00000109189	5.82	7.12	7.37	7.13	6.92	7.09	-0.0537744462270027	3.13275570619573	0.72227062433154	0.92531265947948	4:52590971-52659335:-	USP46	17;GO:0001662,biological_process behavioral fear response;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007610,biological_process behavior;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008343,biological_process adult feeding behavior;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0032228,biological_process regulation of synaptic transmission, GABAergic;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0048149,biological_process behavioral response to ethanol;GO:0060013,biological_process righting reflex;GO:0101005,molecular_function ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 46 [Source:HGNC Symbol%3BAcc:HGNC:20075]
ENSG00000157741	3.30	3.26	2.97	3.17	3.15	3.01	0.0416558442376545	3.68390228634426	0.722329788959652	0.92531265947948	7:139230355-139308236:+	UBN2	3;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm	NA	ubinuclein 2 [Source:HGNC Symbol%3BAcc:HGNC:21931]
ENSG00000127528	1.46	1.53	1.04	1.27	1.00	1.39	0.133763335061018	0.592307334660843	0.722482013135716	0.925355028735835	19:16324816-16327874:+	KLF2	33;GO:0000790,cellular_component nuclear chromatin;GO:0000902,biological_process cell morphogenesis;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0034101,biological_process erythrocyte homeostasis;GO:0034616,biological_process response to laminar fluid shear stress;GO:0035264,biological_process multicellular organism growth;GO:0036003,biological_process positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0043249,biological_process erythrocyte maturation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0060509,biological_process Type I pneumocyte differentiation;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071409,biological_process cellular response to cycloheximide;GO:0071498,biological_process cellular response to fluid shear stress;GO:0071499,biological_process cellular response to laminar fluid shear stress;GO:1901653,biological_process cellular response to peptide	NA	Kruppel like factor 2 [Source:HGNC Symbol%3BAcc:HGNC:6347]
ENSG00000188647	4.99	5.12	6.29	5.93	5.89	5.40	-0.0537347116235397	2.88425332136258	0.722511958310458	0.925355028735835	9:69709521-69759959:-	PTAR1	6;GO:0004659,molecular_function prenyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0008318,molecular_function protein prenyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018342,biological_process protein prenylation;GO:1990234,cellular_component transferase complex	NA	protein prenyltransferase alpha subunit repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30449]
ENSG00000099866	0.63	0.71	0.92	1.11	1.12	0.31	-0.141168347453375	0.297600584796452	0.722590527720509	0.925360179572339	19:489175-505342:+	MADCAM1	16;GO:0002687,biological_process positive regulation of leukocyte migration;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007165,biological_process signal transduction;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007568,biological_process aging;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0043113,biological_process receptor clustering;GO:0050776,biological_process regulation of immune response;GO:0050901,biological_process leukocyte tethering or rolling;GO:0098640,molecular_function integrin binding involved in cell-matrix adhesion	MADCAM1; mucosal vascular addressin cell adhesion molecule 1; K06779	mucosal vascular addressin cell adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:6765]
ENSG00000145041	11.84	13.30	11.62	12.45	13.15	12.10	-0.0286196743077176	5.81322829934116	0.722676108371673	0.925374307119618	3:51395866-51500002:-	DCAF1	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000166,molecular_function nucleotide binding;GO:0001650,cellular_component fibrillar center;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008180,cellular_component COP9 signalosome;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0030183,biological_process B cell differentiation;GO:0030331,molecular_function estrogen receptor binding;GO:0033151,biological_process V(D)J recombination;GO:0035212,biological_process cell competition in a multicellular organism;GO:1990244,molecular_function histone kinase activity (H2A-T120 specific);GO:1990245,biological_process histone H2A-T120 phosphorylation	DCAF1, VPRBP; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]; K11789	DDB1 and CUL4 associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:30911]
ENSG00000185697	10.64	11.27	11.91	11.95	10.86	12.03	-0.032488742059914	4.69979576527606	0.722854609659914	0.925507402754875	8:66562174-66614247:-	MYBL1	12;GO:0000278,biological_process mitotic cell cycle;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001135,molecular_function transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030154,biological_process cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	MYB proto-oncogene like 1 [Source:HGNC Symbol%3BAcc:HGNC:7547]
ENSG00000128915	21.96	21.39	24.79	22.52	23.84	23.64	-0.0249413681539863	6.10300657293048	0.722947237924886	0.92553053469076	15:60419608-60479160:-	ICE2	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008023,cellular_component transcription elongation factor complex;GO:0015030,cellular_component Cajal body;GO:0016604,cellular_component nuclear body;GO:0035327,cellular_component transcriptionally active chromatin;GO:0035363,cellular_component histone locus body;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042796,biological_process snRNA transcription from RNA polymerase III promoter;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter	NA	interactor of little elongation complex ELL subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:29885]
ENSG00000103460	1.19	0.81	0.93	0.79	1.24	1.19	-0.104170332760017	1.07992326134864	0.723330373108541	0.92584493930296	16:52438004-52547802:-	TOX3	13;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0034056,molecular_function estrogen response element binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051219,molecular_function phosphoprotein binding	NA	TOX high mobility group box family member 3 [Source:HGNC Symbol%3BAcc:HGNC:11972]
ENSG00000012174	15.09	14.12	17.27	15.72	15.15	17.21	-0.0328660971434098	4.64836437217288	0.723341998014993	0.92584493930296	X:21839635-21885424:+	MBTPS2	22;GO:0000139,cellular_component Golgi membrane;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006508,biological_process proteolysis;GO:0006629,biological_process lipid metabolic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0051004,biological_process regulation of lipoprotein lipase activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	MBTPS2; S2P endopeptidase [EC:3.4.24.85]; K07765	membrane bound transcription factor peptidase%2C site 2 [Source:HGNC Symbol%3BAcc:HGNC:15455]
ENSG00000186834	62.49	62.56	56.52	57.84	61.05	60.98	0.0237683486663182	6.02334875739663	0.723452978367327	0.925891516700034	17:45148501-45152101:+	HEXIM1	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007507,biological_process heart development;GO:0017069,molecular_function snRNA binding;GO:0045736,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0097322,molecular_function 7SK snRNA binding;GO:1901798,biological_process positive regulation of signal transduction by p53 class mediator	NA	hexamethylene bisacetamide inducible 1 [Source:HGNC Symbol%3BAcc:HGNC:24953]
ENSG00000120129	29.83	21.87	29.68	29.24	22.59	33.15	-0.0462978752744776	4.94731084564649	0.723669476689776	0.926073114860845	5:172768089-172771195:-	DUSP1	41;GO:0000188,biological_process inactivation of MAPK activity;GO:0001706,biological_process endoderm formation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0006979,biological_process response to oxidative stress;GO:0007049,biological_process cell cycle;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008330,molecular_function protein tyrosine/threonine phosphatase activity;GO:0009416,biological_process response to light stimulus;GO:0010033,biological_process response to organic substance;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0019838,molecular_function growth factor binding;GO:0032355,biological_process response to estradiol;GO:0032526,biological_process response to retinoic acid;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033574,biological_process response to testosterone;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0042542,biological_process response to hydrogen peroxide;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0051384,biological_process response to glucocorticoid;GO:0051447,biological_process negative regulation of meiotic cell cycle;GO:0051591,biological_process response to cAMP;GO:0051592,biological_process response to calcium ion;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071850,biological_process mitotic cell cycle arrest;GO:0090266,biological_process regulation of mitotic cell cycle spindle assembly checkpoint;GO:2000279,biological_process negative regulation of DNA biosynthetic process	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:3064]
ENSG00000064042	0.63	0.89	0.69	0.64	0.81	0.64	0.0702364608014859	1.89890665833069	0.723767484829505	0.926101585287736	4:41359606-41700044:+	LIMCH1	3;GO:0003779,molecular_function actin binding;GO:0031032,biological_process actomyosin structure organization;GO:0046872,molecular_function metal ion binding	NA	LIM and calponin homology domains 1 [Source:HGNC Symbol%3BAcc:HGNC:29191]
ENSG00000283154	5.47	5.09	5.05	4.64	5.49	5.09	0.0493082268190349	3.25165643898839	0.723873101030215	0.926101585287736	3:158962234-159897366:+	IQCJ-SCHIP1	NA	NA	IQCJ-SCHIP1 readthrough [Source:HGNC Symbol%3BAcc:HGNC:38842]
ENSG00000111271	8.94	9.53	9.49	9.20	10.06	9.47	-0.0293510044190619	4.96444141974501	0.72395428285281	0.926101585287736	12:111686055-111757107:+	ACAD10	11;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0016787,molecular_function hydrolase activity;GO:0033539,biological_process fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	acyl-CoA dehydrogenase family member 10 [Source:HGNC Symbol%3BAcc:HGNC:21597]
ENSG00000081913	3.13	2.63	2.70	2.89	3.09	2.80	-0.0345407560368298	3.90642650721779	0.724024260642332	0.926101585287736	18:62715449-62980433:+	PHLPP1	22;GO:0002667,biological_process regulation of T cell anergy;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006915,biological_process apoptotic process;GO:0009649,biological_process entrainment of circadian clock;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0031965,cellular_component nuclear membrane;GO:0042981,biological_process regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0046328,biological_process regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0090036,biological_process regulation of protein kinase C signaling;GO:1900744,biological_process regulation of p38MAPK cascade	PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]; K16340	PH domain and leucine rich repeat protein phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:20610]
ENSG00000105298	10.20	10.62	10.57	10.91	10.99	10.40	-0.030557025358417	4.60939169593195	0.724152476974052	0.926101585287736	19:3610640-3626815:-	CACTIN	26;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007275,biological_process multicellular organism development;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031665,biological_process negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0032717,biological_process negative regulation of interleukin-8 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0034122,biological_process negative regulation of toll-like receptor signaling pathway;GO:0045087,biological_process innate immune response;GO:0060339,biological_process negative regulation of type I interferon-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor	NA	cactin%2C spliceosome C complex subunit [Source:HGNC Symbol%3BAcc:HGNC:29938]
ENSG00000156858	15.69	13.94	15.06	14.42	15.13	14.66	0.0329216792587863	4.7117436345414	0.724278157807937	0.926101585287736	16:30650716-30656440:+	PRR14	1;GO:0005515,molecular_function protein binding	NA	proline rich 14 [Source:HGNC Symbol%3BAcc:HGNC:28458]
ENSG00000053900	16.65	15.24	15.68	15.95	16.00	16.92	-0.0249386107405059	5.29356564825904	0.724718457436766	0.926101585287736	4:25377212-25418498:+	ANAPC4	18;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0019903,molecular_function protein phosphatase binding;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC4; anaphase-promoting complex subunit 4; K03351	anaphase promoting complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:19990]
ENSG00000184156	0.49	0.42	0.51	0.44	0.45	0.70	-0.132854910439837	0.615330432675238	0.7248266358524	0.926101585287736	8:132120857-132481019:-	KCNQ3	21;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005516,molecular_function calmodulin binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033268,cellular_component node of Ranvier;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0043194,cellular_component axon initial segment;GO:0055085,biological_process transmembrane transport;GO:0060081,biological_process membrane hyperpolarization;GO:0071805,biological_process potassium ion transmembrane transport	KCNQ3, KV7.3; potassium voltage-gated channel KQT-like subfamily member 3; K04928	potassium voltage-gated channel subfamily Q member 3 [Source:HGNC Symbol%3BAcc:HGNC:6297]
ENSG00000107404	25.27	24.52	28.17	25.90	26.31	27.89	-0.0251095316501409	5.79102948083147	0.725172397313157	0.926101585287736	1:1335275-1349350:-	DVL1	72;GO:0001505,biological_process regulation of neurotransmitter levels;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007269,biological_process neurotransmitter secretion;GO:0007275,biological_process multicellular organism development;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0007528,biological_process neuromuscular junction development;GO:0008013,molecular_function beta-catenin binding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016328,cellular_component lateral plasma membrane;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0021915,biological_process neural tube development;GO:0022007,biological_process convergent extension involved in neural plate elongation;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032091,biological_process negative regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034504,biological_process protein localization to nucleus;GO:0035176,biological_process social behavior;GO:0035372,biological_process protein localization to microtubule;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043113,biological_process receptor clustering;GO:0043197,cellular_component dendritic spine;GO:0045202,cellular_component synapse;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048365,molecular_function Rac GTPase binding;GO:0048668,biological_process collateral sprouting;GO:0048675,biological_process axon extension;GO:0048813,biological_process dendrite morphogenesis;GO:0050808,biological_process synapse organization;GO:0050821,biological_process protein stabilization;GO:0060029,biological_process convergent extension involved in organogenesis;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060134,biological_process prepulse inhibition;GO:0060997,biological_process dendritic spine morphogenesis;GO:0071340,biological_process skeletal muscle acetylcholine-gated channel clustering;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090103,biological_process cochlea morphogenesis;GO:0090179,biological_process planar cell polarity pathway involved in neural tube closure;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0098793,cellular_component presynapse;GO:0099054,biological_process presynapse assembly;GO:1903827,biological_process regulation of cellular protein localization;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:1905386,biological_process positive regulation of protein localization to presynapse;GO:1990909,cellular_component Wnt signalosome;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential	DVL; segment polarity protein dishevelled; K02353	dishevelled segment polarity protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3084]
ENSG00000161955	5.71	5.45	6.25	5.86	5.23	5.69	0.0700346582255222	2.15634722180848	0.725193931353964	0.926101585287736	17:7558291-7561608:+	TNFSF13	18;GO:0002376,biological_process immune system process;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0043488,biological_process regulation of mRNA stability;GO:0048298,biological_process positive regulation of isotype switching to IgA isotypes;GO:0070062,cellular_component extracellular exosome	TNFSF13, APRIL, CD256; tumor necrosis factor ligand superfamily member 13; K05475	TNF superfamily member 13 [Source:HGNC Symbol%3BAcc:HGNC:11928]
ENSG00000025156	14.36	12.72	13.69	11.87	13.73	14.56	0.0368971058657773	4.45239510207824	0.725208206411662	0.926101585287736	6:122399545-122433119:+	HSF2	19;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001162,molecular_function RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	heat shock transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:5225]
ENSG00000167105	26.80	28.25	25.00	28.41	26.87	27.42	-0.0407750085090199	3.70934241396775	0.72525447046869	0.926101585287736	17:50271405-50281485:+	TMEM92	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 92 [Source:HGNC Symbol%3BAcc:HGNC:26579]
ENSG00000178988	86.38	84.78	83.07	84.89	84.60	82.13	0.0270590658818344	5.01289041498643	0.725281423908312	0.926101585287736	4:6707700-6709880:-	MRFAP1L1	2;GO:0005515,molecular_function protein binding;GO:0042802,molecular_function identical protein binding	NA	Morf4 family associated protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:28796]
ENSG00000138606	3.85	3.25	3.21	2.77	3.46	3.73	0.0654753609966348	2.79151009827009	0.72528750141379	0.926101585287736	15:45167213-45201175:-	SHF	4;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0009967,biological_process positive regulation of signal transduction	NA	Src homology 2 domain containing F [Source:HGNC Symbol%3BAcc:HGNC:25116]
ENSG00000136758	93.26	88.92	86.48	85.73	88.51	92.53	0.0220360826119495	7.74461581081045	0.725475022155875	0.926101585287736	10:27110111-27155266:-	YME1L1	23;GO:0000166,molecular_function nucleotide binding;GO:0004176,molecular_function ATP-dependent peptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006508,biological_process proteolysis;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0007005,biological_process mitochondrion organization;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0034214,biological_process protein hexamerization;GO:0034982,biological_process mitochondrial protein processing;GO:0035694,biological_process mitochondrial protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding	NA	YME1 like 1 ATPase [Source:HGNC Symbol%3BAcc:HGNC:12843]
ENSG00000132842	14.83	17.41	16.17	15.30	17.03	17.39	-0.0304064208564248	5.75939251962394	0.725481672470503	0.926101585287736	5:78000524-78294755:-	AP3B1	23;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006622,biological_process protein targeting to lysosome;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007596,biological_process blood coagulation;GO:0008089,biological_process anterograde axonal transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019882,biological_process antigen processing and presentation;GO:0019903,molecular_function protein phosphatase binding;GO:0030117,cellular_component membrane coat;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032438,biological_process melanosome organization;GO:0048007,biological_process antigen processing and presentation, exogenous lipid antigen via MHC class Ib;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0051138,biological_process positive regulation of NK T cell differentiation;GO:1904115,cellular_component axon cytoplasm	AP3B; AP-3 complex subunit beta; K12397	adaptor related protein complex 3 beta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:566]
ENSG00000165646	0.69	0.93	0.95	0.92	1.13	0.78	-0.132129260195961	0.616549451086405	0.725493479415607	0.926101585287736	10:117241092-117279430:+	SLC18A2	26;GO:0001975,biological_process response to amphetamine;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0006837,biological_process serotonin transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0007626,biological_process locomotory behavior;GO:0008021,cellular_component synaptic vesicle;GO:0008504,molecular_function monoamine transmembrane transporter activity;GO:0009636,biological_process response to toxic substance;GO:0009791,biological_process post-embryonic development;GO:0015222,molecular_function serotonin transmembrane transporter activity;GO:0015842,biological_process aminergic neurotransmitter loading into synaptic vesicle;GO:0015844,biological_process monoamine transport;GO:0015872,biological_process dopamine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042137,biological_process sequestering of neurotransmitter;GO:0055085,biological_process transmembrane transport;GO:0070083,cellular_component clathrin-sculpted monoamine transport vesicle membrane;GO:0098700,biological_process neurotransmitter loading into synaptic vesicle;GO:1903427,biological_process negative regulation of reactive oxygen species biosynthetic process	SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2; K08155	solute carrier family 18 member A2 [Source:HGNC Symbol%3BAcc:HGNC:10935]
ENSG00000157653	1.12	1.04	0.75	0.97	1.10	1.12	-0.128038331399558	0.639669583390708	0.725512296312975	0.926101585287736	9:113410053-113429684:+	C9orf43	1;GO:0005515,molecular_function protein binding	NA	chromosome 9 open reading frame 43 [Source:HGNC Symbol%3BAcc:HGNC:23570]
ENSG00000153558	7.33	6.85	7.79	7.62	7.26	7.96	-0.0400058866859799	3.50314344685388	0.725550164436511	0.926101585287736	3:33277024-33403662:+	FBXL2	17;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0010506,biological_process regulation of autophagy;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019903,molecular_function protein phosphatase binding;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0036312,molecular_function phosphatidylinositol 3-kinase regulatory subunit binding	NA	F-box and leucine rich repeat protein 2 [Source:HGNC Symbol%3BAcc:HGNC:13598]
ENSG00000122435	16.90	15.05	15.75	14.95	16.13	18.21	-0.0332924590742619	4.58081250160629	0.725703778294921	0.926101585287736	1:100133149-100150497:+	TRMT13	7;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008175,molecular_function tRNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	tRNA methyltransferase 13 homolog [Source:HGNC Symbol%3BAcc:HGNC:25502]
ENSG00000124225	29.82	15.31	30.80	29.99	19.94	30.69	-0.0700833475626336	4.81332887868365	0.725707818690692	0.926101585287736	20:57648391-57711536:-	PMEPA1	17;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0009968,biological_process negative regulation of signal transduction;GO:0010008,cellular_component endosome membrane;GO:0010991,biological_process negative regulation of SMAD protein complex assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031901,cellular_component early endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050699,molecular_function WW domain binding;GO:0060394,biological_process negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0070412,molecular_function R-SMAD binding	NA	prostate transmembrane protein%2C androgen induced 1 [Source:HGNC Symbol%3BAcc:HGNC:14107]
ENSG00000163624	1.94	1.66	2.39	1.46	2.25	1.98	0.100017671220548	1.51673351780014	0.725720125451757	0.926101585287736	4:84582978-84651338:+	CDS1	17;GO:0004142,molecular_function diacylglycerol cholinephosphotransferase activity;GO:0004605,molecular_function phosphatidate cytidylyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006655,biological_process phosphatidylglycerol biosynthetic process;GO:0006657,biological_process CDP-choline pathway;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007165,biological_process signal transduction;GO:0007602,biological_process phototransduction;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0016779,molecular_function nucleotidyltransferase activity	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]; K00981	CDP-diacylglycerol synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:1800]
ENSG00000167065	8.01	7.46	7.83	8.10	7.53	6.86	0.069550970560452	2.15672348355113	0.72574469557585	0.926101585287736	22:30652050-30667890:-	DUSP18	17;GO:0000188,biological_process inactivation of MAPK activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035970,biological_process peptidyl-threonine dephosphorylation	NA	dual specificity phosphatase 18 [Source:HGNC Symbol%3BAcc:HGNC:18484]
ENSG00000170677	13.42	14.41	12.79	14.83	13.89	13.14	-0.0359037643150679	4.47235025308258	0.725864323273961	0.926101585287736	18:70288900-70330200:+	SOCS6	18;GO:0001772,cellular_component immunological synapse;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006952,biological_process defense response;GO:0007259,biological_process JAK-STAT cascade;GO:0009968,biological_process negative regulation of signal transduction;GO:0010498,biological_process proteasomal protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0043687,biological_process post-translational protein modification;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0050868,biological_process negative regulation of T cell activation	NA	suppressor of cytokine signaling 6 [Source:HGNC Symbol%3BAcc:HGNC:16833]
ENSG00000131944	4.60	5.78	4.91	6.73	5.41	4.14	-0.0878279124856844	1.8175139799673	0.725884310620755	0.926101585287736	19:32972208-32978222:+	FAAP24	10;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0036297,biological_process interstrand cross-link repair;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043240,cellular_component Fanconi anaemia nuclear complex	FAAP24; fanconi anemia-associated protein; K10898	Fanconi anemia core complex associated protein 24 [Source:HGNC Symbol%3BAcc:HGNC:28467]
ENSG00000204070	10.07	11.02	12.19	9.73	11.61	10.76	0.0628609833643328	2.41869689359257	0.726043705609928	0.926101585287736	20:45361936-45376798:+	SYS1	13;GO:0000042,biological_process protein targeting to Golgi;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030173,cellular_component integral component of Golgi membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0043001,biological_process Golgi to plasma membrane protein transport	NA	SYS1%2C golgi trafficking protein [Source:HGNC Symbol%3BAcc:HGNC:16162]
ENSG00000072163	1.15	1.63	1.97	1.82	1.11	1.48	0.107612322537845	1.01958113880653	0.726087242575436	0.926101585287736	2:127638380-127681786:-	LIMS2	15;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030054,cellular_component cell junction;GO:0034329,biological_process cell junction assembly;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045216,biological_process cell-cell junction organization;GO:0046872,molecular_function metal ion binding;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:2000178,biological_process negative regulation of neural precursor cell proliferation;GO:2000346,biological_process negative regulation of hepatocyte proliferation;GO:2001046,biological_process positive regulation of integrin-mediated signaling pathway	NA	LIM zinc finger domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:16084]
ENSG00000120784	7.76	7.46	7.53	8.65	7.57	7.42	-0.0408547200636693	3.64980257471851	0.726254001299289	0.926101585287736	19:37613748-37692337:-	ZFP30	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	ZFP30 zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:29555]
ENSG00000222011	4.74	5.77	5.76	5.48	5.87	5.68	-0.0614666701724695	2.73698822914731	0.726300297913063	0.926101585287736	7:102748970-102809225:+	FAM185A	1;GO:0005829,cellular_component cytosol	NA	family with sequence similarity 185 member A [Source:HGNC Symbol%3BAcc:HGNC:22412]
ENSG00000168701	31.45	29.63	29.75	30.95	32.85	29.92	-0.0302598384621014	4.35147680108245	0.726319001929505	0.926101585287736	16:67227102-67229278:+	TMEM208	7;GO:0005773,cellular_component vacuole;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006624,biological_process vacuolar protein processing;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 208 [Source:HGNC Symbol%3BAcc:HGNC:25015]
ENSG00000125814	5.85	5.17	6.99	6.12	7.28	5.67	-0.0573148961182414	2.52928177316676	0.72639807641502	0.926101585287736	20:23374518-23421519:-	NAPB	17;GO:0005483,molecular_function soluble NSF attachment protein activity;GO:0005515,molecular_function protein binding;GO:0005774,cellular_component vacuolar membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0010807,biological_process regulation of synaptic vesicle priming;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019905,molecular_function syntaxin binding;GO:0031201,cellular_component SNARE complex;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035494,biological_process SNARE complex disassembly;GO:0043209,cellular_component myelin sheath;GO:0061025,biological_process membrane fusion;GO:0070044,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0070062,cellular_component extracellular exosome	NA	NSF attachment protein beta [Source:HGNC Symbol%3BAcc:HGNC:15751]
ENSG00000198818	100.24	106.99	102.76	104.07	101.76	101.28	0.0228023602899718	5.62077997287488	0.726588268850603	0.926101585287736	6:166319727-166342591:-	SFT2D1	5;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport	NA	SFT2 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21102]
ENSG00000130717	19.06	18.20	21.61	21.05	18.06	18.82	0.0400283319730653	4.11731720671427	0.726603590762262	0.926101585287736	9:131523800-131531268:-	UCK1	14;GO:0000166,molecular_function nucleotide binding;GO:0004849,molecular_function uridine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006206,biological_process pyrimidine nucleobase metabolic process;GO:0008152,biological_process metabolic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0043097,biological_process pyrimidine nucleoside salvage;GO:0044206,biological_process UMP salvage;GO:0044211,biological_process CTP salvage	udk, UCK; uridine kinase [EC:2.7.1.48]; K00876	uridine-cytidine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:14859]
ENSG00000180773	19.90	18.39	18.16	20.10	19.91	18.14	-0.0281554371867967	4.86108730177225	0.726641414450258	0.926101585287736	11:93144170-93197964:-	SLC36A4	15;GO:0005774,cellular_component vacuolar membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0015180,molecular_function L-alanine transmembrane transporter activity;GO:0015193,molecular_function L-proline transmembrane transporter activity;GO:0015196,molecular_function L-tryptophan transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015808,biological_process L-alanine transport;GO:0015824,biological_process proline transport;GO:0015827,biological_process tryptophan transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1904271,biological_process L-proline import across plasma membrane;GO:1904556,biological_process L-tryptophan transmembrane transport	SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter); K14209	solute carrier family 36 member 4 [Source:HGNC Symbol%3BAcc:HGNC:19660]
ENSG00000155097	83.01	92.40	87.35	83.76	90.80	85.78	0.0234207144703461	6.64479372070515	0.726725036988498	0.926101585287736	8:103021062-103073051:+	ATP6V1C1	24;GO:0000221,cellular_component vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008553,molecular_function hydrogen-exporting ATPase activity, phosphorylative mechanism;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016241,biological_process regulation of macroautophagy;GO:0016469,cellular_component proton-transporting two-sector ATPase complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033180,cellular_component proton-transporting V-type ATPase, V1 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0045177,cellular_component apical part of cell;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV1C, ATP6C; V-type H+-transporting ATPase subunit C; K02148	ATPase H+ transporting V1 subunit C1 [Source:HGNC Symbol%3BAcc:HGNC:856]
ENSG00000114993	26.08	25.18	24.59	25.13	26.92	25.74	-0.024026153977999	5.58793432357816	0.726787576950768	0.926101585287736	2:74425835-74442422:-	RTKN	14;GO:0000166,molecular_function nucleotide binding;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0017048,molecular_function Rho GTPase binding;GO:0017049,molecular_function GTP-Rho binding;GO:0032185,biological_process septin cytoskeleton organization;GO:0034260,biological_process negative regulation of GTPase activity;GO:0042981,biological_process regulation of apoptotic process	NA	rhotekin [Source:HGNC Symbol%3BAcc:HGNC:10466]
ENSG00000135912	7.79	7.49	6.45	7.29	7.65	6.43	0.0358324254365505	4.69914273151406	0.726916895331107	0.926101585287736	2:218710844-218755416:+	TTLL4	15;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0006464,biological_process cellular protein modification process;GO:0015631,molecular_function tubulin binding;GO:0016874,molecular_function ligase activity;GO:0018095,biological_process protein polyglutamylation;GO:0018200,biological_process peptidyl-glutamic acid modification;GO:0042995,cellular_component cell projection;GO:0070739,molecular_function protein-glutamic acid ligase activity;GO:0070740,molecular_function tubulin-glutamic acid ligase activity	NA	tubulin tyrosine ligase like 4 [Source:HGNC Symbol%3BAcc:HGNC:28976]
ENSG00000152402	1.92	1.91	1.78	1.59	1.87	1.91	0.0713555000919154	2.15678560857336	0.727036694589754	0.926101585287736	11:106674011-107018524:-	GUCY1A2	15;GO:0000166,molecular_function nucleotide binding;GO:0004383,molecular_function guanylate cyclase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006182,biological_process cGMP biosynthetic process;GO:0007165,biological_process signal transduction;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0020037,molecular_function heme binding;GO:0030828,biological_process positive regulation of cGMP biosynthetic process;GO:0035556,biological_process intracellular signal transduction	GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]; K12318	guanylate cyclase 1 soluble subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:4684]
ENSG00000074695	103.22	99.69	97.65	99.73	99.69	99.18	0.02137043395016	7.2577613062565	0.727076218106719	0.926101585287736	18:59327822-59359962:-	LMAN1	29;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005537,molecular_function mannose binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006457,biological_process protein folding;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007030,biological_process Golgi organization;GO:0007596,biological_process blood coagulation;GO:0010638,biological_process positive regulation of organelle organization;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030017,cellular_component sarcomere;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030246,molecular_function carbohydrate binding;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0044220,cellular_component host cell perinuclear region of cytoplasm;GO:0046872,molecular_function metal ion binding;GO:0048208,biological_process COPII vesicle coating;GO:0051082,molecular_function unfolded protein binding;GO:0070062,cellular_component extracellular exosome	LMAN1, ERGIC53; lectin, mannose-binding 1; K10080	lectin%2C mannose binding 1 [Source:HGNC Symbol%3BAcc:HGNC:6631]
ENSG00000144579	32.02	31.86	33.73	33.03	35.63	31.65	-0.0257309474458971	5.34202918072717	0.727114369189674	0.926101585287736	2:218398255-218405941:+	CTDSP1	16;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006470,biological_process protein dephosphorylation;GO:0008420,molecular_function CTD phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0046872,molecular_function metal ion binding;GO:0050768,biological_process negative regulation of neurogenesis;GO:0070062,cellular_component extracellular exosome;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	CTD small phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:21614]
ENSG00000142687	40.80	43.64	38.50	39.47	41.69	40.69	0.0229958240268672	7.00629462329694	0.727182919285321	0.926101585287736	1:35433489-35557950:-	KIAA0319L	8;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0070062,cellular_component extracellular exosome	NA	KIAA0319 like [Source:HGNC Symbol%3BAcc:HGNC:30071]
ENSG00000136631	20.39	20.51	21.44	20.45	20.64	20.71	0.0249554348397078	5.32528398836822	0.727227649131729	0.926101585287736	1:150067292-150145327:+	VPS45	15;GO:0000139,cellular_component Golgi membrane;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0007596,biological_process blood coagulation;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport	VPS45; vacuolar protein sorting-associated protein 45; K12479	vacuolar protein sorting 45 homolog [Source:HGNC Symbol%3BAcc:HGNC:14579]
ENSG00000163041	399.78	476.67	398.19	389.18	456.13	413.53	0.0287872521161278	7.70854404505641	0.727232737961722	0.926101585287736	1:226061850-226072001:+	H3F3A	47;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000228,cellular_component nuclear chromosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000786,cellular_component nucleosome;GO:0000788,cellular_component nuclear nucleosome;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001649,biological_process osteoblast differentiation;GO:0001740,cellular_component Barr body;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006334,biological_process nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006997,biological_process nucleus organization;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0007338,biological_process single fertilization;GO:0007420,biological_process brain development;GO:0007566,biological_process embryo implantation;GO:0007596,biological_process blood coagulation;GO:0008283,biological_process cell proliferation;GO:0008584,biological_process male gonad development;GO:0009725,biological_process response to hormone;GO:0030307,biological_process positive regulation of cell growth;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031508,biological_process pericentric heterochromatin assembly;GO:0031509,biological_process telomeric heterochromatin assembly;GO:0032200,biological_process telomere organization;GO:0035264,biological_process multicellular organism growth;GO:0042393,molecular_function histone binding;GO:0042692,biological_process muscle cell differentiation;GO:0043234,cellular_component protein complex;GO:0044267,biological_process cellular protein metabolic process;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046982,molecular_function protein heterodimerization activity;GO:0048477,biological_process oogenesis;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070062,cellular_component extracellular exosome;GO:0090230,biological_process regulation of centromere complex assembly;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1902340,biological_process negative regulation of chromosome condensation	H3; histone H3; K11253	H3 histone family member 3A [Source:HGNC Symbol%3BAcc:HGNC:4764]
ENSG00000139146	31.63	34.40	37.55	37.99	34.69	34.16	-0.0331919127597251	4.70487298389732	0.727252269463386	0.926101585287736	12:31280583-31327058:-	FAM60A	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016580,cellular_component Sin3 complex;GO:0030336,biological_process negative regulation of cell migration	NA	family with sequence similarity 60 member A [Source:HGNC Symbol%3BAcc:HGNC:30702]
ENSG00000146411	2.33	2.12	1.91	2.43	1.76	1.90	0.0750905444645605	1.99655850995731	0.727257583730597	0.926101585287736	6:133988696-134052636:-	SLC2A12	21;GO:0005215,molecular_function transporter activity;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0008645,biological_process hexose transport;GO:0012505,cellular_component endomembrane system;GO:0015758,biological_process glucose transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0035428,biological_process hexose transmembrane transport;GO:0046323,biological_process glucose import;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055056,molecular_function D-glucose transmembrane transporter activity;GO:0055085,biological_process transmembrane transport;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 2 member 12 [Source:HGNC Symbol%3BAcc:HGNC:18067]
ENSG00000135469	4.34	5.10	4.87	5.30	5.28	4.57	-0.076192107007022	2.12848334788768	0.7272782999579	0.926101585287736	12:56266857-56270966:+	COQ10A	6;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0045333,biological_process cellular respiration;GO:0048039,molecular_function ubiquinone binding	NA	coenzyme Q10A [Source:HGNC Symbol%3BAcc:HGNC:26515]
ENSG00000123607	7.76	8.28	8.05	8.21	8.09	8.42	-0.0286387798691466	5.01257761960365	0.727290121324483	0.926101585287736	2:165857474-165953843:-	TTC21B	15;GO:0000790,cellular_component nuclear chromatin;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007224,biological_process smoothened signaling pathway;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0021591,biological_process ventricular system development;GO:0021798,biological_process forebrain dorsal/ventral pattern formation;GO:0030991,cellular_component intraciliary transport particle A;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0061512,biological_process protein localization to cilium;GO:0097542,cellular_component ciliary tip	NA	tetratricopeptide repeat domain 21B [Source:HGNC Symbol%3BAcc:HGNC:25660]
ENSG00000204387	297.88	238.28	313.05	306.14	260.56	310.96	-0.0323628693610164	6.02451303903951	0.727294598403324	0.926101585287736	6:31834607-31839766:+	C6orf48	NA	NA	chromosome 6 open reading frame 48 [Source:HGNC Symbol%3BAcc:HGNC:19078]
ENSG00000116032	1.99	2.14	2.38	2.75	1.82	2.27	-0.0623521378923488	2.83146784984715	0.727412217459339	0.926101585287736	19:1000418-1009732:+	GRIN3B	26;GO:0004872,molecular_function receptor activity;GO:0004970,molecular_function ionotropic glutamate receptor activity;GO:0005216,molecular_function ion channel activity;GO:0005234,molecular_function extracellular-glutamate-gated ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016594,molecular_function glycine binding;GO:0017146,cellular_component NMDA selective glutamate receptor complex;GO:0030054,cellular_component cell junction;GO:0030594,molecular_function neurotransmitter receptor activity;GO:0034220,biological_process ion transmembrane transport;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0042165,molecular_function neurotransmitter binding;GO:0043025,cellular_component neuronal cell body;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0051205,biological_process protein insertion into membrane;GO:0051924,biological_process regulation of calcium ion transport;GO:0060079,biological_process excitatory postsynaptic potential;GO:0070588,biological_process calcium ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	GRIN3B; glutamate receptor ionotropic, NMDA 3B; K05214	glutamate ionotropic receptor NMDA type subunit 3B [Source:HGNC Symbol%3BAcc:HGNC:16768]
ENSG00000167528	4.20	3.87	2.88	3.24	4.66	2.51	0.0853787590093446	2.38524198787363	0.727422094300768	0.926101585287736	12:48337179-48351414:-	ZNF641	12;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 641 [Source:HGNC Symbol%3BAcc:HGNC:31834]
ENSG00000158458	1.22	1.51	1.65	1.54	1.48	1.60	-0.0724532761487888	2.08119869183793	0.727585500340026	0.926214625753333	5:139846778-140043299:-	NRG2	24;GO:0000165,biological_process MAPK cascade;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0008083,molecular_function growth factor activity;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048513,biological_process animal organ development;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:2000145,biological_process regulation of cell motility	NRG2; neuregulin 2; K05456	neuregulin 2 [Source:HGNC Symbol%3BAcc:HGNC:7998]
ENSG00000007047	13.91	15.55	15.09	14.20	15.55	14.24	0.026811699589087	5.11253768441189	0.727672402123746	0.92621828594893	19:45079287-45305283:+	MARK4	37;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000930,cellular_component gamma-tubulin complex;GO:0001578,biological_process microtubule bundle formation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0008017,molecular_function microtubule binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030010,biological_process establishment of cell polarity;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043015,molecular_function gamma-tubulin binding;GO:0043068,biological_process positive regulation of programmed cell death;GO:0043130,molecular_function ubiquitin binding;GO:0050321,molecular_function tau-protein kinase activity;GO:0051301,biological_process cell division;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	microtubule affinity regulating kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:13538]
ENSG00000089639	6.53	6.50	8.12	7.23	7.17	7.52	-0.0356100509530971	4.39841932836443	0.727737609188747	0.92621828594893	19:19629475-19643667:-	GMIP	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	GEM interacting protein [Source:HGNC Symbol%3BAcc:HGNC:24852]
ENSG00000171530	101.50	94.95	95.68	105.55	99.45	94.70	-0.0233537042813297	5.93937785587457	0.727953104317328	0.926375127357539	5:77691165-77868780:-	TBCA	13;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0007021,biological_process tubulin complex assembly;GO:0007023,biological_process post-chaperonin tubulin folding pathway;GO:0015630,cellular_component microtubule cytoskeleton;GO:0048487,molecular_function beta-tubulin binding;GO:0051087,molecular_function chaperone binding;GO:0070062,cellular_component extracellular exosome	NA	tubulin folding cofactor A [Source:HGNC Symbol%3BAcc:HGNC:11579]
ENSG00000102786	13.31	14.05	14.76	14.64	13.86	14.73	-0.0268312592618376	5.32336602788887	0.728010099683622	0.926375127357539	13:51354076-51454264:-	INTS6	9;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007165,biological_process signal transduction;GO:0015629,cellular_component actin cytoskeleton;GO:0016180,biological_process snRNA processing;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:14879]
ENSG00000064607	31.64	33.47	34.62	34.09	34.68	33.36	-0.0228944073845418	6.94794964532361	0.728158379179664	0.926402589859183	19:18990887-19034023:-	SUGP2	8;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body	NA	SURP and G-patch domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18641]
ENSG00000243646	22.49	17.10	16.70	18.75	19.06	17.49	0.0434222470821141	4.42789786756899	0.728180944917107	0.926402589859183	21:33266357-33310187:+	IL10RB	13;GO:0004872,molecular_function receptor activity;GO:0004920,molecular_function interleukin-10 receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032002,cellular_component interleukin-28 receptor complex;GO:0051607,biological_process defense response to virus;GO:0070062,cellular_component extracellular exosome	IL10RB, CD210B; interleukin 10 receptor beta; K05135	interleukin 10 receptor subunit beta [Source:HGNC Symbol%3BAcc:HGNC:5965]
ENSG00000115524	113.85	118.63	118.04	106.78	123.99	116.96	0.0233344835276217	8.87691591230353	0.728438973418283	0.926635886148918	2:197389783-197435091:-	SF3B1	18;GO:0000245,biological_process spliceosomal complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0034693,cellular_component U11/U12 snRNP;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0071004,cellular_component U2-type prespliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	SF3B1, SAP155; splicing factor 3B subunit 1; K12828	splicing factor 3b subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:10768]
ENSG00000185238	17.67	15.38	17.90	16.69	17.83	18.04	-0.0269624470805803	4.90821889480427	0.728528435089304	0.926647586194625	11:20387529-20509294:+	PRMT3	20;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0008469,molecular_function histone-arginine N-methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0019919,biological_process peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032259,biological_process methylation;GO:0034969,biological_process histone arginine methylation;GO:0035242,molecular_function protein-arginine omega-N asymmetric methyltransferase activity;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0046872,molecular_function metal ion binding	NA	protein arginine methyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:30163]
ENSG00000118557	0.53	1.00	0.66	0.51	0.86	0.65	0.0907630739912538	1.29934067896892	0.728688626478537	0.926647586194625	16:72112156-72176878:-	PMFBP1	1;GO:0005737,cellular_component cytoplasm	NA	polyamine modulated factor 1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17728]
ENSG00000171853	13.69	14.19	12.18	14.30	12.49	14.40	-0.032785650767266	5.10967051557803	0.728700981378903	0.926647586194625	2:3379674-3485094:+	TRAPPC12	20;GO:0000776,cellular_component kinetochore;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051259,biological_process protein oligomerization;GO:0051310,biological_process metaphase plate congression;GO:0061024,biological_process membrane organization;GO:0090234,biological_process regulation of kinetochore assembly;GO:1905342,biological_process positive regulation of protein localization to kinetochore	NA	trafficking protein particle complex 12 [Source:HGNC Symbol%3BAcc:HGNC:24284]
ENSG00000125388	1.13	1.09	1.03	0.93	1.29	1.31	-0.111357206541862	1.22830361473027	0.728746776478847	0.926647586194625	4:2963607-3040747:+	GRK4	22;GO:0000166,molecular_function nucleotide binding;GO:0002029,biological_process desensitization of G-protein coupled receptor protein signaling pathway;GO:0002031,biological_process G-protein coupled receptor internalization;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004703,molecular_function G-protein coupled receptor kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0030425,cellular_component dendrite;GO:0031623,biological_process receptor internalization;GO:0043025,cellular_component neuronal cell body;GO:0050254,molecular_function rhodopsin kinase activity;GO:0097381,cellular_component photoreceptor disc membrane	GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]; K08291	G protein-coupled receptor kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:4543]
ENSG00000077782	36.47	35.19	39.15	38.69	37.36	37.53	-0.0224402774500126	6.76198726197371	0.72895266634044	0.926814447125257	8:38411137-38468834:-	FGFR1	99;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001525,biological_process angiogenesis;GO:0001657,biological_process ureteric bud development;GO:0001701,biological_process in utero embryonic development;GO:0001759,biological_process organ induction;GO:0001764,biological_process neuron migration;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002062,biological_process chondrocyte differentiation;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005007,molecular_function fibroblast growth factor-activated receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0007037,biological_process vacuolar phosphate transport;GO:0007420,biological_process brain development;GO:0007435,biological_process salivary gland morphogenesis;GO:0007605,biological_process sensory perception of sound;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010468,biological_process regulation of gene expression;GO:0010518,biological_process positive regulation of phospholipase activity;GO:0010629,biological_process negative regulation of gene expression;GO:0010863,biological_process positive regulation of phospholipase C activity;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0017134,molecular_function fibroblast growth factor binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021769,biological_process orbitofrontal cortex development;GO:0021847,biological_process ventricular zone neuroblast division;GO:0030324,biological_process lung development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030901,biological_process midbrain development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035607,biological_process fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042472,biological_process inner ear morphogenesis;GO:0042473,biological_process outer ear morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043009,biological_process chordate embryonic development;GO:0043235,cellular_component receptor complex;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045595,biological_process regulation of cell differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045787,biological_process positive regulation of cell cycle;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048339,biological_process paraxial mesoderm development;GO:0048378,biological_process regulation of lateral mesodermal cell fate specification;GO:0048469,biological_process cell maturation;GO:0048514,biological_process blood vessel morphogenesis;GO:0048699,biological_process generation of neurons;GO:0048705,biological_process skeletal system morphogenesis;GO:0048762,biological_process mesenchymal cell differentiation;GO:0051174,biological_process regulation of phosphorus metabolic process;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060117,biological_process auditory receptor cell development;GO:0060445,biological_process branching involved in salivary gland morphogenesis;GO:0060484,biological_process lung-associated mesenchyme development;GO:0060665,biological_process regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling;GO:0070640,biological_process vitamin D3 metabolic process;GO:0090080,biological_process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0090272,biological_process negative regulation of fibroblast growth factor production;GO:0090722,molecular_function receptor-receptor interaction;GO:1903465,biological_process positive regulation of mitotic cell cycle DNA replication;GO:2000546,biological_process positive regulation of endothelial cell chemotaxis to fibroblast growth factor;GO:2000830,biological_process positive regulation of parathyroid hormone secretion;GO:2001239,biological_process regulation of extrinsic apoptotic signaling pathway in absence of ligand	FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]; K04362	fibroblast growth factor receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:3688]
ENSG00000118495	39.25	36.05	36.67	36.87	40.24	33.72	0.029156224983257	5.69413209213002	0.7292697300279	0.927122609467054	6:143940299-144064599:-	PLAGL1	20;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007050,biological_process cell cycle arrest;GO:0016604,cellular_component nuclear body;GO:0030154,biological_process cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	PLAG1 like zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:9046]
ENSG00000117010	2.37	3.43	2.47	3.47	2.54	2.75	-0.0937972539707942	1.87878185222698	0.729634199460701	0.927335243256643	1:40531560-40548169:+	ZNF684	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 684 [Source:HGNC Symbol%3BAcc:HGNC:28418]
ENSG00000005156	9.21	10.97	10.61	9.53	9.63	11.15	0.0296801722142259	5.00250774541033	0.729658856407387	0.927335243256643	17:34980493-35009743:+	LIG3	27;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003909,molecular_function DNA ligase activity;GO:0003910,molecular_function DNA ligase (ATP) activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006260,biological_process DNA replication;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006288,biological_process base-excision repair, DNA ligation;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008270,molecular_function zinc ion binding;GO:0016874,molecular_function ligase activity;GO:0046872,molecular_function metal ion binding;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0051301,biological_process cell division;GO:0071897,biological_process DNA biosynthetic process;GO:0090298,biological_process negative regulation of mitochondrial DNA replication	LIG3; DNA ligase 3 [EC:6.5.1.1]; K10776	DNA ligase 3 [Source:HGNC Symbol%3BAcc:HGNC:6600]
ENSG00000203805	4.88	4.78	4.82	5.80	4.34	5.20	-0.0700094889219103	2.11476674081361	0.72966110697556	0.927335243256643	10:120456953-120589855:+	PLPP4	11;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006644,biological_process phospholipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008195,molecular_function phosphatidate phosphatase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042802,molecular_function identical protein binding;GO:0046839,biological_process phospholipid dephosphorylation	NA	phospholipid phosphatase 4 [Source:HGNC Symbol%3BAcc:HGNC:23531]
ENSG00000176018	6.91	7.01	7.20	5.81	7.18	7.48	0.0551834283977852	2.73877474178169	0.730070314022918	0.927667345285637	5:90515610-90529584:-	LYSMD3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	LysM domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:26969]
ENSG00000055332	19.57	20.81	20.13	19.25	20.46	20.12	0.025010107071826	5.05741237503884	0.730071884000273	0.927667345285637	2:37099209-37157065:-	EIF2AK2	53;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001819,biological_process positive regulation of cytokine production;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004694,molecular_function eukaryotic translation initiation factor 2alpha kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006412,biological_process translation;GO:0006468,biological_process protein phosphorylation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009615,biological_process response to virus;GO:0009636,biological_process response to toxic substance;GO:0010998,biological_process regulation of translational initiation by eIF2 alpha phosphorylation;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017148,biological_process negative regulation of translation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0030683,biological_process evasion or tolerance by virus of host immune response;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032722,biological_process positive regulation of chemokine production;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0033689,biological_process negative regulation of osteoblast proliferation;GO:0034198,biological_process cellular response to amino acid starvation;GO:0035455,biological_process response to interferon-alpha;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046777,biological_process protein autophosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051607,biological_process defense response to virus;GO:1900225,biological_process regulation of NLRP3 inflammasome complex assembly;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1901532,biological_process regulation of hematopoietic progenitor cell differentiation;GO:1902033,biological_process regulation of hematopoietic stem cell proliferation;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]; K16195	eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:9437]
ENSG00000132024	16.78	16.79	17.02	17.47	16.48	16.21	0.0242574000004923	5.59005078994207	0.730388197646951	0.927974278136295	19:13906200-13930879:+	CC2D1A	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	NA	coiled-coil and C2 domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:30237]
ENSG00000111737	22.16	24.92	25.15	24.44	24.65	21.87	0.0352899418883089	4.10766053326325	0.730560566733149	0.928098282147024	12:120095094-120117502:-	RAB35	34;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0008104,biological_process protein localization;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0019003,molecular_function GDP binding;GO:0019882,biological_process antigen processing and presentation;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031175,biological_process neuron projection development;GO:0031253,cellular_component cell projection membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032456,biological_process endocytic recycling;GO:0036010,biological_process protein localization to endosome;GO:0042470,cellular_component melanosome;GO:0045171,cellular_component intercellular bridge;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0048227,biological_process plasma membrane to endosome transport;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:1990090,biological_process cellular response to nerve growth factor stimulus	RAB35, RAB1C; Ras-related protein Rab-35; K07876	RAB35%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9774]
ENSG00000150768	25.22	25.65	25.79	24.42	26.73	24.85	0.0241172067060867	5.63083850980837	0.730864266972	0.928232525026292	11:112024813-112064390:+	DLAT	19;GO:0004742,molecular_function dihydrolipoyllysine-residue acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005967,cellular_component mitochondrial pyruvate dehydrogenase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006086,biological_process acetyl-CoA biosynthetic process from pyruvate;GO:0006090,biological_process pyruvate metabolic process;GO:0006099,biological_process tricarboxylic acid cycle;GO:0008152,biological_process metabolic process;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0030431,biological_process sleep;GO:0034604,molecular_function pyruvate dehydrogenase (NAD+) activity;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0043209,cellular_component myelin sheath;GO:0045254,cellular_component pyruvate dehydrogenase complex	DLAT, aceF, pdhC; pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]; K00627	dihydrolipoamide S-acetyltransferase [Source:HGNC Symbol%3BAcc:HGNC:2896]
ENSG00000120008	22.52	21.60	21.31	20.53	22.39	22.02	0.0229809144363589	6.32190013855381	0.73091428904924	0.928232525026292	10:120851174-120909524:+	WDR11	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	WD repeat domain 11 [Source:HGNC Symbol%3BAcc:HGNC:13831]
ENSG00000117262	3.88	4.38	5.20	4.26	4.86	3.87	0.0654061758551118	2.78289399919463	0.730935352214433	0.928232525026292	1:145607989-145670648:+	GPR89A	17;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0008308,molecular_function voltage-gated anion channel activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0032580,cellular_component Golgi cisterna membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051452,biological_process intracellular pH reduction;GO:1903959,biological_process regulation of anion transmembrane transport	NA	G protein-coupled receptor 89A [Source:HGNC Symbol%3BAcc:HGNC:31984]
ENSG00000168096	12.32	11.14	11.87	11.17	11.50	12.27	0.0320019354912275	4.6030684367775	0.730965353430436	0.928232525026292	16:4696509-4734378:-	ANKS3	1;GO:0005515,molecular_function protein binding	NA	ankyrin repeat and sterile alpha motif domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:29422]
ENSG00000188026	14.05	12.38	15.83	15.76	12.16	13.50	0.0468253895910521	4.19387415060597	0.731171650937526	0.928399519546595	12:123470053-123533718:-	RILPL1	19;GO:0003382,biological_process epithelial cell morphogenesis;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0031267,molecular_function small GTPase binding;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0046983,molecular_function protein dimerization activity;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis;GO:1901214,biological_process regulation of neuron death;GO:1903445,biological_process protein transport from ciliary membrane to plasma membrane	NA	Rab interacting lysosomal protein like 1 [Source:HGNC Symbol%3BAcc:HGNC:26814]
ENSG00000108518	1133.85	1175.27	1033.77	1139.13	1185.97	1099.07	-0.0231389773333507	9.58624471683123	0.731478581389269	0.928692190124839	17:4945651-4949061:-	PFN1	41;GO:0000774,molecular_function adenyl-nucleotide exchange factor activity;GO:0001843,biological_process neural tube closure;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0010033,biological_process response to organic substance;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0032232,biological_process negative regulation of actin filament bundle assembly;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0032781,biological_process positive regulation of ATPase activity;GO:0043005,cellular_component neuron projection;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050434,biological_process positive regulation of viral transcription;GO:0050821,biological_process protein stabilization;GO:0051054,biological_process positive regulation of DNA metabolic process;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0070062,cellular_component extracellular exosome;GO:0070064,molecular_function proline-rich region binding;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0072562,cellular_component blood microparticle;GO:1900029,biological_process positive regulation of ruffle assembly	PFN; profilin; K05759	profilin 1 [Source:HGNC Symbol%3BAcc:HGNC:8881]
ENSG00000135245	170.40	166.86	189.26	194.51	154.90	194.21	-0.0332637526262728	5.08439489880595	0.731590822675459	0.928692190124839	7:128455848-128458418:+	HILPDA	17;GO:0001819,biological_process positive regulation of cytokine production;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006950,biological_process response to stress;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010884,biological_process positive regulation of lipid storage;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030141,cellular_component secretory granule;GO:0034389,biological_process lipid particle organization;GO:0035425,biological_process autocrine signaling	NA	hypoxia inducible lipid droplet associated [Source:HGNC Symbol%3BAcc:HGNC:28859]
ENSG00000116133	203.35	232.56	200.64	205.22	241.49	207.50	-0.0282437573182915	8.38063604985656	0.731679205350827	0.928692190124839	1:54849632-54887218:-	DHCR24	45;GO:0000139,cellular_component Golgi membrane;GO:0000246,molecular_function delta24(24-1) sterol reductase activity;GO:0003824,molecular_function catalytic activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0007050,biological_process cell cycle arrest;GO:0007265,biological_process Ras protein signal transduction;GO:0008104,biological_process protein localization;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009725,biological_process response to hormone;GO:0009888,biological_process tissue development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016125,biological_process sterol metabolic process;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016614,molecular_function oxidoreductase activity, acting on CH-OH group of donors;GO:0016628,molecular_function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0019899,molecular_function enzyme binding;GO:0030539,biological_process male genitalia development;GO:0031639,biological_process plasminogen activation;GO:0033489,biological_process cholesterol biosynthetic process via desmosterol;GO:0033490,biological_process cholesterol biosynthetic process via lathosterol;GO:0042605,molecular_function peptide antigen binding;GO:0042987,biological_process amyloid precursor protein catabolic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043588,biological_process skin development;GO:0050614,molecular_function delta24-sterol reductase activity;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0061024,biological_process membrane organization;GO:1901214,biological_process regulation of neuron death	DHCR24, DWF1; Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-]; K09828	24-dehydrocholesterol reductase [Source:HGNC Symbol%3BAcc:HGNC:2859]
ENSG00000165916	83.70	91.62	79.83	86.65	86.64	88.04	-0.0247319113854537	6.92010074464651	0.731701411376857	0.928692190124839	11:47418768-47426473:-	PSMC3	55;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001824,biological_process blastocyst development;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017025,molecular_function TBP-class protein binding;GO:0022624,cellular_component proteasome accessory complex;GO:0030163,biological_process protein catabolic process;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031595,cellular_component nuclear proteasome complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0036402,molecular_function proteasome-activating ATPase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0043921,biological_process modulation by host of viral transcription;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMC3, RPT5; 26S proteasome regulatory subunit T5; K03065	proteasome 26S subunit%2C ATPase 3 [Source:HGNC Symbol%3BAcc:HGNC:9549]
ENSG00000117593	18.07	22.42	18.30	18.38	21.71	17.62	0.0333952273984642	5.23357493066498	0.73185727222505	0.928795043464834	1:173824502-173858546:+	DARS2	18;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004815,molecular_function aspartate-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0016874,molecular_function ligase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043039,biological_process tRNA aminoacylation;GO:0050560,molecular_function aspartate-tRNA(Asn) ligase activity;GO:0070145,biological_process mitochondrial asparaginyl-tRNA aminoacylation	aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]; K01876	aspartyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:25538]
ENSG00000029364	36.41	40.82	38.83	39.51	40.47	39.01	-0.028062232169958	5.28967151507481	0.731998259515932	0.928879001775839	14:69398014-69462388:+	SLC39A9	8;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 39 member 9 [Source:HGNC Symbol%3BAcc:HGNC:20182]
ENSG00000174227	18.17	17.85	16.89	18.21	18.44	17.55	-0.0233199233298282	5.8046531733412	0.732224923272277	0.929071652108634	4:499209-540196:+	PIGG	12;GO:0003824,molecular_function catalytic activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016780,molecular_function phosphotransferase activity, for other substituted phosphate groups;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0051267,molecular_function CP2 mannose-ethanolamine phosphotransferase activity	PIGG, GPI7; ethanolamine phosphate transferase 2 subunit G [EC:2.7.-.-]; K05310	phosphatidylinositol glycan anchor biosynthesis class G [Source:HGNC Symbol%3BAcc:HGNC:25985]
ENSG00000188243	61.46	68.69	61.04	66.23	61.08	61.02	0.0278683198295947	4.72395336211929	0.732354690873872	0.929108033500807	13:75525218-75549439:-	COMMD6	7;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0051059,molecular_function NF-kappaB binding	NA	COMM domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:24015]
ENSG00000174579	14.08	13.97	13.61	14.32	13.54	13.28	0.0296232397169768	4.58743950462074	0.732420881866174	0.929108033500807	3:136148921-136197241:-	MSL2	7;GO:0005654,cellular_component nucleoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0043984,biological_process histone H4-K16 acetylation;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0072487,cellular_component MSL complex	NA	MSL complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:25544]
ENSG00000181827	6.22	6.99	6.82	5.97	6.71	7.04	0.029014828156883	4.77554878347972	0.732565247344145	0.929108033500807	15:56087279-56243266:-	RFX7	6;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter	NA	regulatory factor X7 [Source:HGNC Symbol%3BAcc:HGNC:25777]
ENSG00000070018	6.95	6.73	7.09	6.65	7.82	6.90	-0.0275073354051098	5.09496297749264	0.732605365912458	0.929108033500807	12:12116024-12267012:-	LRP6	81;GO:0001843,biological_process neural tube closure;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003344,biological_process pericardium morphogenesis;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006897,biological_process endocytosis;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007268,biological_process chemical synaptic transmission;GO:0007275,biological_process multicellular organism development;GO:0009880,biological_process embryonic pattern specification;GO:0009986,cellular_component cell surface;GO:0014029,biological_process neural crest formation;GO:0014033,biological_process neural crest cell differentiation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0017147,molecular_function Wnt-protein binding;GO:0019210,molecular_function kinase inhibitor activity;GO:0019534,molecular_function toxin transporter activity;GO:0021587,biological_process cerebellum morphogenesis;GO:0021794,biological_process thalamus development;GO:0021987,biological_process cerebral cortex development;GO:0030917,biological_process midbrain-hindbrain boundary development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0034185,molecular_function apolipoprotein binding;GO:0034392,biological_process negative regulation of smooth muscle cell apoptotic process;GO:0035261,biological_process external genitalia morphogenesis;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042813,molecular_function Wnt-activated receptor activity;GO:0043025,cellular_component neuronal cell body;GO:0043235,cellular_component receptor complex;GO:0043434,biological_process response to peptide hormone;GO:0044332,biological_process Wnt signaling pathway involved in dorsal/ventral axis specification;GO:0044335,biological_process canonical Wnt signaling pathway involved in neural crest cell differentiation;GO:0044340,biological_process canonical Wnt signaling pathway involved in regulation of cell proliferation;GO:0045121,cellular_component membrane raft;GO:0045202,cellular_component synapse;GO:0045787,biological_process positive regulation of cell cycle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060021,biological_process palate development;GO:0060026,biological_process convergent extension;GO:0060059,biological_process embryonic retina morphogenesis in camera-type eye;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060325,biological_process face morphogenesis;GO:0060535,biological_process trachea cartilage morphogenesis;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0071397,biological_process cellular response to cholesterol;GO:0071542,biological_process dopaminergic neuron differentiation;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0071936,molecular_function coreceptor activity involved in Wnt signaling pathway;GO:0072659,biological_process protein localization to plasma membrane;GO:0090009,biological_process primitive streak formation;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090118,biological_process receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport;GO:0090244,biological_process Wnt signaling pathway involved in somitogenesis;GO:0090245,biological_process axis elongation involved in somitogenesis;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901998,biological_process toxin transport;GO:1904886,biological_process beta-catenin destruction complex disassembly;GO:1904928,molecular_function coreceptor activity involved in canonical Wnt signaling pathway;GO:1904948,biological_process midbrain dopaminergic neuron differentiation;GO:1904953,biological_process Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;GO:1990851,cellular_component Wnt-Frizzled-LRP5/6 complex;GO:1990909,cellular_component Wnt signalosome;GO:2000055,biological_process positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	LRP5_6; low density lipoprotein receptor-related protein 5/6; K03068	LDL receptor related protein 6 [Source:HGNC Symbol%3BAcc:HGNC:6698]
ENSG00000105364	33.66	30.90	35.35	34.59	35.43	32.70	-0.0237535705880181	5.53906927558111	0.732712667690001	0.929108033500807	19:10251900-10260045:+	MRPL4	12;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0022626,cellular_component cytosolic ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L4, MRPL4, rplD; large subunit ribosomal protein L4; K02926	mitochondrial ribosomal protein L4 [Source:HGNC Symbol%3BAcc:HGNC:14276]
ENSG00000198408	65.22	58.47	64.15	63.65	60.16	62.72	0.0230331078393194	7.44891021389593	0.732747621133697	0.929108033500807	10:101784442-101818465:-	MGEA5	16;GO:0004415,molecular_function hyalurononglucosaminidase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006493,biological_process protein O-linked glycosylation;GO:0006516,biological_process glycoprotein catabolic process;GO:0006517,biological_process protein deglycosylation;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016231,molecular_function beta-N-acetylglucosaminidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0102166,molecular_function [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity;GO:0102167,molecular_function [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity;GO:0102571,molecular_function [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	NCOAT, MGEA5; protein O-GlcNAcase / histone acetyltransferase [EC:3.2.1.169 2.3.1.48]; K15719	meningioma expressed antigen 5 (hyaluronidase) [Source:HGNC Symbol%3BAcc:HGNC:7056]
ENSG00000148459	4.62	4.61	4.47	5.07	5.43	3.89	-0.0556529506017662	2.62278315762259	0.732777543540877	0.929108033500807	10:26697658-26746798:+	PDSS1	11;GO:0000010,molecular_function trans-hexaprenyltranstransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050347,molecular_function trans-octaprenyltranstransferase activity;GO:0051290,biological_process protein heterotetramerization;GO:1990234,cellular_component transferase complex	PDSS1; decaprenyl-diphosphate synthase subunit 1 [EC:2.5.1.91]; K12504	decaprenyl diphosphate synthase subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:17759]
ENSG00000034510	17368.60	18237.09	17044.79	16946.59	18251.60	17124.59	0.0207579320423768	11.1744307592877	0.733092706434231	0.929341578288396	2:84905624-84906675:+	TMSB10	6;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization	NA	thymosin beta 10 [Source:HGNC Symbol%3BAcc:HGNC:11879]
ENSG00000197062	12.14	11.17	12.50	11.15	11.88	12.28	0.0368152305228421	4.10625120684889	0.733111474631433	0.929341578288396	6:28267009-28278224:+	ZSCAN26	9;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 26 [Source:HGNC Symbol%3BAcc:HGNC:12978]
ENSG00000148498	53.27	55.86	48.44	50.21	54.15	51.87	0.0232995435241428	7.74618564653618	0.733437776143986	0.929611077888157	10:34109559-34815325:-	PARD3	36;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0005938,cellular_component cell cortex;GO:0006461,biological_process protein complex assembly;GO:0006612,biological_process protein targeting to membrane;GO:0007049,biological_process cell cycle;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0007409,biological_process axonogenesis;GO:0008289,molecular_function lipid binding;GO:0008356,biological_process asymmetric cell division;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0019903,molecular_function protein phosphatase binding;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0031643,biological_process positive regulation of myelination;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0033269,cellular_component internode region of axon;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0044295,cellular_component axonal growth cone;GO:0051301,biological_process cell division;GO:0060341,biological_process regulation of cellular localization;GO:0070830,biological_process bicellular tight junction assembly;GO:0090162,biological_process establishment of epithelial cell polarity	PARD3; partitioning defective protein 3; K04237	par-3 family cell polarity regulator [Source:HGNC Symbol%3BAcc:HGNC:16051]
ENSG00000122484	10.62	10.15	10.18	10.89	9.91	9.69	0.0355491834508142	4.24526535774678	0.733477700986042	0.929611077888157	1:92298964-92402056:+	RPAP2	17;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008420,molecular_function CTD phosphatase activity;GO:0009301,biological_process snRNA transcription;GO:0016591,cellular_component DNA-directed RNA polymerase II, holoenzyme;GO:0016787,molecular_function hydrolase activity;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0070940,biological_process dephosphorylation of RNA polymerase II C-terminal domain	NA	RNA polymerase II associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:25791]
ENSG00000157227	216.63	185.57	216.75	210.76	189.99	212.41	0.0258321266449516	8.66783695187166	0.733548739862603	0.929611077888157	14:22836556-22849027:+	MMP14	63;GO:0001503,biological_process ossification;GO:0001525,biological_process angiogenesis;GO:0001541,biological_process ovarian follicle development;GO:0001666,biological_process response to hypoxia;GO:0001935,biological_process endothelial cell proliferation;GO:0001958,biological_process endochondral ossification;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005796,cellular_component Golgi lumen;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006979,biological_process response to oxidative stress;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008584,biological_process male gonad development;GO:0009612,biological_process response to mechanical stimulus;GO:0009725,biological_process response to hormone;GO:0010831,biological_process positive regulation of myotube differentiation;GO:0010952,biological_process positive regulation of peptidase activity;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0016485,biological_process protein processing;GO:0016504,molecular_function peptidase activator activity;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030307,biological_process positive regulation of cell growth;GO:0030324,biological_process lung development;GO:0030335,biological_process positive regulation of cell migration;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031638,biological_process zymogen activation;GO:0035987,biological_process endodermal cell differentiation;GO:0035988,biological_process chondrocyte proliferation;GO:0042470,cellular_component melanosome;GO:0043615,biological_process astrocyte cell migration;GO:0043627,biological_process response to estrogen;GO:0044354,cellular_component macropinosome;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048771,biological_process tissue remodeling;GO:0048870,biological_process cell motility;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0060348,biological_process bone development;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0097094,biological_process craniofacial suture morphogenesis;GO:1905523,biological_process positive regulation of macrophage migration;GO:1990834,biological_process response to odorant	MMP14; matrix metalloproteinase-14 (membrane-inserted) [EC:3.4.24.80]; K07763	matrix metallopeptidase 14 [Source:HGNC Symbol%3BAcc:HGNC:7160]
ENSG00000126768	34.97	32.42	33.63	33.39	33.20	33.38	0.0303211685703293	4.6248821472369	0.734118659949894	0.930173392820494	X:48893446-48898143:-	TIMM17B	14;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0015450,molecular_function P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031305,cellular_component integral component of mitochondrial inner membrane	NA	translocase of inner mitochondrial membrane 17B [Source:HGNC Symbol%3BAcc:HGNC:17310]
ENSG00000205339	81.74	79.07	77.71	79.24	82.83	81.80	-0.0200887969968978	8.01888397160413	0.734212243483773	0.930173392820494	11:9384621-9448126:+	IPO7	22;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007165,biological_process signal transduction;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0030695,molecular_function GTPase regulator activity;GO:0042393,molecular_function histone binding;GO:0045087,biological_process innate immune response;GO:0046332,molecular_function SMAD binding;GO:0050790,biological_process regulation of catalytic activity	NA	importin 7 [Source:HGNC Symbol%3BAcc:HGNC:9852]
ENSG00000214087	67.90	68.33	64.71	65.71	72.67	67.71	-0.0256428768722736	5.40231120822252	0.734217264388561	0.930173392820494	17:81681173-81683924:-	ARL16	5;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction	NA	ADP ribosylation factor like GTPase 16 [Source:HGNC Symbol%3BAcc:HGNC:27902]
ENSG00000125246	11.35	9.43	12.28	10.71	10.97	12.75	-0.0389549659511677	3.90043973638789	0.734426769239945	0.93034386024854	13:99606668-99897134:+	CLYBL	8;GO:0000287,molecular_function magnesium ion binding;GO:0003824,molecular_function catalytic activity;GO:0004474,molecular_function malate synthase activity;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	citrate lyase beta like [Source:HGNC Symbol%3BAcc:HGNC:18355]
ENSG00000131263	26.48	27.82	22.76	24.88	26.42	27.87	-0.0306403832023517	5.61123648500721	0.734605406917715	0.930433587169006	X:74585216-74614617:-	RLIM	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000209,biological_process protein polyubiquitination;GO:0003714,molecular_function transcription corepressor activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0060816,biological_process random inactivation of X chromosome;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1900095,biological_process regulation of dosage compensation by inactivation of X chromosome	NA	ring finger protein%2C LIM domain interacting [Source:HGNC Symbol%3BAcc:HGNC:13429]
ENSG00000122390	36.31	29.21	33.82	35.69	32.39	34.45	-0.0270326068911312	5.06617421937151	0.734719051342111	0.930433587169006	16:3443610-3486963:+	NAA60	17;GO:0000139,cellular_component Golgi membrane;GO:0004402,molecular_function histone acetyltransferase activity;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006334,biological_process nucleosome assembly;GO:0006474,biological_process N-terminal protein amino acid acetylation;GO:0007059,biological_process chromosome segregation;GO:0008080,molecular_function N-acetyltransferase activity;GO:0008283,biological_process cell proliferation;GO:0010485,molecular_function H4 histone acetyltransferase activity;GO:0016020,cellular_component membrane;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017196,biological_process N-terminal peptidyl-methionine acetylation;GO:0042803,molecular_function protein homodimerization activity;GO:0043967,biological_process histone H4 acetylation	NA	N(alpha)-acetyltransferase 60%2C NatF catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:25875]
ENSG00000109445	50.26	42.33	50.77	47.84	45.55	48.65	0.0302883010238973	5.5273851932566	0.734722470106388	0.930433587169006	4:141220886-141234697:+	ZNF330	9;GO:0000775,cellular_component chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0030496,cellular_component midbody;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 330 [Source:HGNC Symbol%3BAcc:HGNC:15462]
ENSG00000197620	13.39	10.15	14.11	12.48	13.27	10.84	0.0714149557535477	2.61476083637539	0.734906881782828	0.930572184389497	X:149540354-149550510:+	CXorf40A	1;GO:0005515,molecular_function protein binding	NA	chromosome X open reading frame 40A [Source:HGNC Symbol%3BAcc:HGNC:28089]
ENSG00000119661	16.92	11.86	15.31	17.41	16.57	12.54	-0.0507623619285604	3.14434676787891	0.735163264359247	0.93070915042898	14:73644874-73703732:+	DNAL1	4;GO:0036157,cellular_component outer dynein arm;GO:0036158,biological_process outer dynein arm assembly;GO:0043014,molecular_function alpha-tubulin binding;GO:0045504,molecular_function dynein heavy chain binding	DNAL1; dynein light chain 1, axonemal; K10411	dynein axonemal light chain 1 [Source:HGNC Symbol%3BAcc:HGNC:23247]
ENSG00000163026	6.17	4.68	5.44	5.40	5.15	5.43	0.0515018798050125	3.56652066442876	0.735169284736972	0.93070915042898	2:24029339-24049575:-	WDCP	2;GO:0019900,molecular_function kinase binding;GO:0051259,biological_process protein oligomerization	NA	WD repeat and coiled coil containing [Source:HGNC Symbol%3BAcc:HGNC:26157]
ENSG00000075711	52.19	54.32	53.64	52.43	54.94	56.45	-0.0213346863746877	7.41172776137861	0.735239984621492	0.93070915042898	3:197042559-197299300:-	DLG1	105;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001657,biological_process ureteric bud development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001771,biological_process immunological synapse formation;GO:0001772,cellular_component immunological synapse;GO:0001935,biological_process endothelial cell proliferation;GO:0002088,biological_process lens development in camera-type eye;GO:0002369,biological_process T cell cytokine production;GO:0004385,molecular_function guanylate kinase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005605,cellular_component basal lamina;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006470,biological_process protein dephosphorylation;GO:0007015,biological_process actin filament organization;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008104,biological_process protein localization;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008328,cellular_component ionotropic glutamate receptor complex;GO:0008360,biological_process regulation of cell shape;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0014704,cellular_component intercalated disc;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016323,cellular_component basolateral plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0030054,cellular_component cell junction;GO:0030432,biological_process peristalsis;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0030953,biological_process astral microtubule organization;GO:0031253,cellular_component cell projection membrane;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031579,biological_process membrane raft organization;GO:0031594,cellular_component neuromuscular junction;GO:0031641,biological_process regulation of myelination;GO:0032147,biological_process activation of protein kinase activity;GO:0032947,molecular_function protein complex scaffold;GO:0033268,cellular_component node of Ranvier;GO:0034220,biological_process ion transmembrane transport;GO:0034629,biological_process cellular protein complex localization;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035748,cellular_component myelin sheath abaxonal region;GO:0042110,biological_process T cell activation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042383,cellular_component sarcolemma;GO:0042391,biological_process regulation of membrane potential;GO:0042982,biological_process amyloid precursor protein metabolic process;GO:0043113,biological_process receptor clustering;GO:0043219,cellular_component lateral loop;GO:0043268,biological_process positive regulation of potassium ion transport;GO:0043622,biological_process cortical microtubule organization;GO:0044325,molecular_function ion channel binding;GO:0045121,cellular_component membrane raft;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045296,molecular_function cadherin binding;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048608,biological_process reproductive structure development;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048729,biological_process tissue morphogenesis;GO:0048745,biological_process smooth muscle tissue development;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0051660,biological_process establishment of centrosome localization;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060022,biological_process hard palate development;GO:0070062,cellular_component extracellular exosome;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070830,biological_process bicellular tight junction assembly;GO:0072659,biological_process protein localization to plasma membrane;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0097016,molecular_function L27 domain binding;GO:0097025,cellular_component MPP7-DLG1-LIN7 complex;GO:0097120,biological_process receptor localization to synapse;GO:0098911,biological_process regulation of ventricular cardiac muscle cell action potential;GO:1902305,biological_process regulation of sodium ion transmembrane transport;GO:1903286,biological_process regulation of potassium ion import;GO:1903753,biological_process negative regulation of p38MAPK cascade;GO:1903760,biological_process regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:1903764,biological_process regulation of potassium ion export across plasma membrane	DLG1; disks large protein 1; K12076	discs large MAGUK scaffold protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2900]
ENSG00000155393	10.21	9.51	9.09	9.84	11.15	8.82	-0.0344762181887407	4.32881055626835	0.73540104820785	0.930818110676459	16:50065940-50106387:+	HEATR3	4;GO:0005622,cellular_component intracellular;GO:0006606,biological_process protein import into nucleus;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0051082,molecular_function unfolded protein binding	NA	HEAT repeat containing 3 [Source:HGNC Symbol%3BAcc:HGNC:26087]
ENSG00000120519	1.90	1.58	1.73	0.97	2.24	1.65	0.119014887417467	1.0633176911261	0.735477816508543	0.930820364633008	4:146253974-146521964:-	SLC10A7	7;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0015293,molecular_function symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 10 member 7 [Source:HGNC Symbol%3BAcc:HGNC:23088]
ENSG00000166592	59.71	49.55	61.16	57.20	49.80	61.32	0.0324481237147905	6.04620545357899	0.735633652428234	0.930922675868251	16:66921678-66925644:-	RRAD	12;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:1901841,biological_process regulation of high voltage-gated calcium channel activity;GO:1901842,biological_process negative regulation of high voltage-gated calcium channel activity	NA	RRAD%2C Ras related glycolysis inhibitor and calcium channel regulator [Source:HGNC Symbol%3BAcc:HGNC:10446]
ENSG00000129595	10.47	10.68	10.66	10.11	11.79	10.83	-0.0303617670484987	4.47890506937898	0.735713040666665	0.930928233822152	5:112142440-112419316:-	EPB41L4A	8;GO:0003674,molecular_function molecular_function;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008150,biological_process biological_process;GO:0031032,biological_process actomyosin structure organization	NA	erythrocyte membrane protein band 4.1 like 4A [Source:HGNC Symbol%3BAcc:HGNC:13278]
ENSG00000111266	7.22	8.43	8.19	7.81	8.02	8.78	-0.0410391324236032	4.02236542990485	0.735802105934968	0.930946034142367	12:12474209-12562383:-	DUSP16	18;GO:0000188,biological_process inactivation of MAPK activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0045204,biological_process MAPK export from nucleus;GO:0045209,biological_process MAPK phosphatase export from nucleus, leptomycin B sensitive	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 16 [Source:HGNC Symbol%3BAcc:HGNC:17909]
ENSG00000184343	0.78	0.37	0.71	0.90	0.58	0.58	-0.0924452197358904	0.615034534373366	0.736008450162282	0.931112198518591	X:153776411-153785732:+	SRPK3	20;GO:0000166,molecular_function nucleotide binding;GO:0000245,biological_process spliceosomal complex assembly;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0007519,biological_process skeletal muscle tissue development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0035556,biological_process intracellular signal transduction;GO:0050684,biological_process regulation of mRNA processing;GO:0060537,biological_process muscle tissue development	NA	SRSF protein kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:11402]
ENSG00000104522	51.32	55.84	51.66	53.32	54.72	49.29	0.0231894604321134	5.95395192256104	0.73610181822048	0.931135419297954	8:143612617-143618048:-	TSTA3	18;GO:0003824,molecular_function catalytic activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0008152,biological_process metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0009226,biological_process nucleotide-sugar biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016853,molecular_function isomerase activity;GO:0019673,biological_process GDP-mannose metabolic process;GO:0019835,biological_process cytolysis;GO:0042351,biological_process 'de novo' GDP-L-fucose biosynthetic process;GO:0042356,molecular_function GDP-4-dehydro-D-rhamnose reductase activity;GO:0042802,molecular_function identical protein binding;GO:0050577,molecular_function GDP-L-fucose synthase activity;GO:0050662,molecular_function coenzyme binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271]; K02377	tissue specific transplantation antigen P35B [Source:HGNC Symbol%3BAcc:HGNC:12390]
ENSG00000174586	2.05	1.59	1.13	1.48	1.12	1.86	0.105608881859485	1.410810489658	0.736484660870971	0.931524770266085	19:58354356-58362848:-	ZNF497	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 497 [Source:HGNC Symbol%3BAcc:HGNC:23714]
ENSG00000146112	52.58	50.25	53.47	57.20	48.58	54.56	-0.0244424813538304	6.60448971507697	0.736599105601697	0.931574599881188	6:30676388-30687895:-	PPP1R18	5;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0019902,molecular_function phosphatase binding	NA	protein phosphatase 1 regulatory subunit 18 [Source:HGNC Symbol%3BAcc:HGNC:29413]
ENSG00000146576	13.47	13.07	13.02	13.59	13.01	14.10	-0.0296177191051122	4.35909864239235	0.736700276726256	0.931607633965262	7:6590016-6608726:+	C7orf26	NA	NA	chromosome 7 open reading frame 26 [Source:HGNC Symbol%3BAcc:HGNC:21702]
ENSG00000150760	19.56	21.60	19.75	19.21	20.92	20.26	0.0222373427770283	6.83983088519746	0.736789176167004	0.931625144520833	10:126905408-127452517:+	DOCK1	25;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006909,biological_process phagocytosis;GO:0006911,biological_process phagocytosis, engulfment;GO:0006915,biological_process apoptotic process;GO:0007010,biological_process cytoskeleton organization;GO:0007165,biological_process signal transduction;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007596,biological_process blood coagulation;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0017124,molecular_function SH3 domain binding;GO:0032045,cellular_component guanyl-nucleotide exchange factor complex;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading	DOCK1; dedicator of cytokinesis protein 1; K13708	dedicator of cytokinesis 1 [Source:HGNC Symbol%3BAcc:HGNC:2987]
ENSG00000130158	10.15	9.81	11.25	10.85	9.39	10.68	0.0269642217430722	6.08330474198741	0.737417323786206	0.932308622269556	19:11199294-11262481:-	DOCK6	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007596,biological_process blood coagulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	dedicator of cytokinesis 6 [Source:HGNC Symbol%3BAcc:HGNC:19189]
ENSG00000006712	41.61	46.34	39.15	41.46	42.77	41.58	0.023054798720337	6.23481564965101	0.737479929272921	0.932308622269556	19:39385851-39391195:-	PAF1	31;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000993,molecular_function RNA polymerase II core binding;GO:0001711,biological_process endodermal cell fate commitment;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006378,biological_process mRNA polyadenylation;GO:0010390,biological_process histone monoubiquitination;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016570,biological_process histone modification;GO:0016584,biological_process nucleosome positioning;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0019827,biological_process stem cell population maintenance;GO:0030054,cellular_component cell junction;GO:0031062,biological_process positive regulation of histone methylation;GO:0031442,biological_process positive regulation of mRNA 3'-end processing;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0033523,biological_process histone H2B ubiquitination;GO:0034504,biological_process protein localization to nucleus;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:1902808,biological_process positive regulation of cell cycle G1/S phase transition	NA	PAF1 homolog%2C Paf1/RNA polymerase II complex component [Source:HGNC Symbol%3BAcc:HGNC:25459]
ENSG00000186897	4.95	3.35	4.33	4.61	4.99	3.94	-0.0651286652374555	1.71849826821334	0.737611546904945	0.932379573682389	12:49332410-49337188:-	C1QL4	7;GO:0005576,cellular_component extracellular region;GO:0005581,cellular_component collagen trimer;GO:0005615,cellular_component extracellular space;GO:0042802,molecular_function identical protein binding;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	NA	complement C1q like 4 [Source:HGNC Symbol%3BAcc:HGNC:31416]
ENSG00000068078	0.95	1.66	0.79	1.33	1.26	1.06	-0.117449417877575	1.65415851721354	0.737686279959296	0.932379573682389	4:1793306-1808872:+	FGFR3	57;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001958,biological_process endochondral ossification;GO:0002062,biological_process chondrocyte differentiation;GO:0003416,biological_process endochondral bone growth;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005007,molecular_function fibroblast growth factor-activated receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007259,biological_process JAK-STAT cascade;GO:0007267,biological_process cell-cell signaling;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009986,cellular_component cell surface;GO:0010518,biological_process positive regulation of phospholipase activity;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017134,molecular_function fibroblast growth factor binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030133,cellular_component transport vesicle;GO:0030282,biological_process bone mineralization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035988,biological_process chondrocyte proliferation;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042531,biological_process positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048640,biological_process negative regulation of developmental growth;GO:0060349,biological_process bone morphogenesis;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070977,biological_process bone maturation;GO:1902178,biological_process fibroblast growth factor receptor apoptotic signaling pathway	FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]; K05094	fibroblast growth factor receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:3690]
ENSG00000062716	200.02	186.72	202.18	197.51	183.90	203.57	0.022023989938251	7.94426639371284	0.737825318575146	0.93239043899846	17:59707191-59842255:+	VMP1	19;GO:0000407,cellular_component pre-autophagosomal structure;GO:0000421,cellular_component autophagosome membrane;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005773,cellular_component vacuole;GO:0005774,cellular_component vacuolar membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0006914,biological_process autophagy;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007030,biological_process Golgi organization;GO:0007155,biological_process cell adhesion;GO:0007566,biological_process embryo implantation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034329,biological_process cell junction assembly	NA	vacuole membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29559]
ENSG00000175203	91.40	93.24	94.32	92.90	90.65	93.65	0.0206323630845704	6.88762632855708	0.737845104509939	0.93239043899846	12:57530101-57547331:-	DCTN2	28;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000776,cellular_component kinetochore;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005869,cellular_component dynactin complex;GO:0005874,cellular_component microtubule;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007017,biological_process microtubule-based process;GO:0007052,biological_process mitotic spindle organization;GO:0008283,biological_process cell proliferation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030286,cellular_component dynein complex;GO:0030426,cellular_component growth cone;GO:0030507,molecular_function spectrin binding;GO:0031982,cellular_component vesicle;GO:0032402,biological_process melanosome transport;GO:0042802,molecular_function identical protein binding;GO:0070062,cellular_component extracellular exosome;GO:0071539,biological_process protein localization to centrosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	DCTN2; dynactin 2; K10424	dynactin subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:2712]
ENSG00000170340	18.98	21.26	20.76	21.31	20.89	20.49	-0.0316196492985182	4.62590958319434	0.737953069521999	0.932431947473185	2:62196112-62224731:+	B3GNT2	17;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0007411,biological_process axon guidance;GO:0007608,biological_process sensory perception of smell;GO:0008378,molecular_function galactosyltransferase activity;GO:0008499,molecular_function UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0008532,molecular_function N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0030311,biological_process poly-N-acetyllactosamine biosynthetic process;GO:0070062,cellular_component extracellular exosome;GO:1990830,biological_process cellular response to leukemia inhibitory factor	B3GNT2; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.149]; K00741	UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:15629]
ENSG00000129245	25.89	22.00	24.58	23.45	25.71	25.36	-0.0237775027388137	5.63937967611725	0.738154182699684	0.932541725494994	17:7591229-7614871:-	FXR2	15;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome	FMR; fragile X mental retardation protein; K15516	FMR1 autosomal homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:4024]
ENSG00000132376	14.68	13.48	13.42	13.86	13.26	13.94	0.0326706804210013	4.33576513936373	0.738245064949809	0.932541725494994	17:1494570-1516888:-	INPP5K	61;GO:0001701,biological_process in utero embryonic development;GO:0001726,cellular_component ruffle;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445,molecular_function inositol-polyphosphate 5-phosphatase activity;GO:0005000,molecular_function vasopressin receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005979,biological_process regulation of glycogen biosynthetic process;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0010829,biological_process negative regulation of glucose transport;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016312,molecular_function inositol bisphosphate phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0032587,cellular_component ruffle membrane;GO:0032868,biological_process response to insulin;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034485,molecular_function phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0034594,molecular_function phosphatidylinositol trisphosphate phosphatase activity;GO:0034595,molecular_function phosphatidylinositol phosphate 5-phosphatase activity;GO:0035305,biological_process negative regulation of dephosphorylation;GO:0035810,biological_process positive regulation of urine volume;GO:0042577,molecular_function lipid phosphatase activity;GO:0042593,biological_process glucose homeostasis;GO:0043005,cellular_component neuron projection;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0045719,biological_process negative regulation of glycogen biosynthetic process;GO:0045869,biological_process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046030,molecular_function inositol trisphosphate phosphatase activity;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0051926,biological_process negative regulation of calcium ion transport;GO:0052658,molecular_function inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0071320,biological_process cellular response to cAMP;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0072661,biological_process protein targeting to plasma membrane;GO:0090315,biological_process negative regulation of protein targeting to membrane;GO:0097178,biological_process ruffle assembly;GO:2000466,biological_process negative regulation of glycogen (starch) synthase activity;GO:2001153,biological_process positive regulation of renal water transport	E3.1.3.56; inositol-1,4,5-trisphosphate 5-phosphatase [EC:3.1.3.56]; K01106	inositol polyphosphate-5-phosphatase K [Source:HGNC Symbol%3BAcc:HGNC:33882]
ENSG00000167191	24.33	26.90	25.12	23.70	30.42	24.62	-0.0347065651563774	5.02413722330583	0.738265329609225	0.932541725494994	16:19856690-19886167:-	GPRC5B	26;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0030295,molecular_function protein kinase activator activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032147,biological_process activation of protein kinase activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0050729,biological_process positive regulation of inflammatory response;GO:0060907,biological_process positive regulation of macrophage cytokine production;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	G protein-coupled receptor class C group 5 member B [Source:HGNC Symbol%3BAcc:HGNC:13308]
ENSG00000204175	2.00	1.46	1.77	1.47	1.60	1.89	0.101653974214171	1.32562057174869	0.73847441558266	0.932664657307805	10:46549043-46555530:-	GPRIN2	1;GO:0005515,molecular_function protein binding	NA	G protein regulated inducer of neurite outgrowth 2 [Source:HGNC Symbol%3BAcc:HGNC:23730]
ENSG00000175591	4.50	2.28	2.99	3.71	2.48	4.35	-0.0817471861952501	2.01578246582769	0.738569383788208	0.932664657307805	11:73218297-73236352:+	P2RY2	15;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006873,biological_process cellular ion homeostasis;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035589,biological_process G-protein coupled purinergic nucleotide receptor signaling pathway;GO:0045028,molecular_function G-protein coupled purinergic nucleotide receptor activity;GO:0070257,biological_process positive regulation of mucus secretion;GO:0097746,biological_process regulation of blood vessel diameter	P2RY2; P2Y purinoceptor 2; K04269	purinergic receptor P2Y2 [Source:HGNC Symbol%3BAcc:HGNC:8541]
ENSG00000102349	5.65	3.74	5.45	5.10	5.23	5.39	-0.049706375402131	2.6310236697957	0.738626656413629	0.932664657307805	X:56232420-56287889:+	KLF8	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016235,cellular_component aggresome;GO:0046872,molecular_function metal ion binding	NA	Kruppel like factor 8 [Source:HGNC Symbol%3BAcc:HGNC:6351]
ENSG00000185219	9.32	8.54	8.15	8.97	8.40	9.42	-0.029375537276111	4.77910403701186	0.738663195520263	0.932664657307805	3:44431719-44477670:-	ZNF445	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	zinc finger protein 445 [Source:HGNC Symbol%3BAcc:HGNC:21018]
ENSG00000204370	41.43	40.81	34.79	36.98	38.73	44.99	-0.0361707528773854	4.71353943600179	0.738756898873762	0.932688098628967	11:112086772-112120013:+	SDHD	15;GO:0000104,molecular_function succinate dehydrogenase activity;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005749,cellular_component mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0006099,biological_process tricarboxylic acid cycle;GO:0006121,biological_process mitochondrial electron transport, succinate to ubiquinone;GO:0008177,molecular_function succinate dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0020037,molecular_function heme binding;GO:0046872,molecular_function metal ion binding;GO:0048039,molecular_function ubiquinone binding;GO:0055114,biological_process oxidation-reduction process	SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit; K00237	NA
ENSG00000185267	3.01	2.37	2.61	1.86	2.02	3.49	0.129273361412928	0.685175742688617	0.738849048498125	0.932709573782897	10:14819249-14838575:-	CDNF	6;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0008083,molecular_function growth factor activity;GO:0031175,biological_process neuron projection development;GO:0071542,biological_process dopaminergic neuron differentiation	NA	cerebral dopamine neurotrophic factor [Source:HGNC Symbol%3BAcc:HGNC:24913]
ENSG00000073050	14.51	16.24	14.90	14.97	16.08	13.99	0.0277828215777747	4.90220892126443	0.73898000055865	0.932780023076523	19:43543039-43580473:-	XRCC1	30;GO:0000012,biological_process single strand break repair;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000790,cellular_component nuclear chromatin;GO:0001666,biological_process response to hypoxia;GO:0003684,molecular_function damaged DNA binding;GO:0003909,molecular_function DNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006284,biological_process base-excision repair;GO:0006288,biological_process base-excision repair, DNA ligation;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010033,biological_process response to organic substance;GO:0010836,biological_process negative regulation of protein ADP-ribosylation;GO:0019899,molecular_function enzyme binding;GO:0021766,biological_process hippocampus development;GO:0032356,molecular_function oxidized DNA binding;GO:0042493,biological_process response to drug;GO:0061819,biological_process telomeric DNA-containing double minutes formation;GO:0070522,cellular_component ERCC4-ERCC1 complex;GO:1903518,biological_process positive regulation of single strand break repair;GO:1904877,biological_process positive regulation of DNA ligase activity;GO:1905765,biological_process negative regulation of protection from non-homologous end joining at telomere;GO:1990599,molecular_function 3' overhang single-stranded DNA endodeoxyribonuclease activity	XRCC1; DNA-repair protein XRCC1; K10803	X-ray repair cross complementing 1 [Source:HGNC Symbol%3BAcc:HGNC:12828]
ENSG00000251493	3.49	3.15	2.95	2.47	2.34	4.28	0.0858971765956267	2.17570660647548	0.739206500699164	0.932905178609705	5:73444826-73448527:-	FOXD1	28;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001822,biological_process kidney development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007411,biological_process axon guidance;GO:0008301,molecular_function DNA binding, bending;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010628,biological_process positive regulation of gene expression;GO:0030154,biological_process cell differentiation;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0032275,biological_process luteinizing hormone secretion;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060678,biological_process dichotomous subdivision of terminal units involved in ureteric bud branching;GO:0072076,biological_process nephrogenic mesenchyme development;GO:0072210,biological_process metanephric nephron development;GO:0072213,biological_process metanephric capsule development;GO:0072267,biological_process metanephric capsule specification;GO:0072268,biological_process pattern specification involved in metanephros development;GO:0090184,biological_process positive regulation of kidney development	NA	forkhead box D1 [Source:HGNC Symbol%3BAcc:HGNC:3802]
ENSG00000107077	9.10	8.29	10.07	8.49	8.76	9.88	0.0326889426337946	5.0101543042234	0.73937951366178	0.932905178609705	9:6720862-7175648:+	KDM4C	29;GO:0000790,cellular_component nuclear chromatin;GO:0001825,biological_process blastocyst formation;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005721,cellular_component pericentric heterochromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0019899,molecular_function enzyme binding;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation;GO:1900113,biological_process negative regulation of histone H3-K9 trimethylation;GO:2000036,biological_process regulation of stem cell population maintenance;GO:2000736,biological_process regulation of stem cell differentiation	NA	lysine demethylase 4C [Source:HGNC Symbol%3BAcc:HGNC:17071]
ENSG00000174749	12.13	12.55	10.59	10.02	7.28	15.98	0.0871076165677245	2.22790315053767	0.739422889753975	0.932905178609705	4:112145396-112195256:+	C4orf32	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 4 open reading frame 32 [Source:HGNC Symbol%3BAcc:HGNC:26813]
ENSG00000143952	17.88	14.93	14.78	16.24	16.30	16.41	-0.0256149367481368	5.5918583670411	0.739452325193555	0.932905178609705	2:63892145-64019072:-	VPS54	18;GO:0000938,cellular_component GARP complex;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006896,biological_process Golgi to vacuole transport;GO:0007041,biological_process lysosomal transport;GO:0015031,biological_process protein transport;GO:0019905,molecular_function syntaxin binding;GO:0032588,cellular_component trans-Golgi network membrane;GO:0040007,biological_process growth;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0050881,biological_process musculoskeletal movement;GO:0060052,biological_process neurofilament cytoskeleton organization	NA	VPS54%2C GARP complex subunit [Source:HGNC Symbol%3BAcc:HGNC:18652]
ENSG00000155858	2.16	1.33	2.66	1.94	3.09	1.69	-0.0877987771993638	1.31823786700672	0.739454930503576	0.932905178609705	5:157743694-157760709:+	LSM11	15;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005683,cellular_component U7 snRNP;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006398,biological_process mRNA 3'-end processing by stem-loop binding and cleavage;GO:0008334,biological_process histone mRNA metabolic process;GO:0016604,cellular_component nuclear body;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0071204,cellular_component histone pre-mRNA 3'end processing complex;GO:0071209,molecular_function U7 snRNA binding;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle	NA	LSM11%2C U7 small nuclear RNA associated [Source:HGNC Symbol%3BAcc:HGNC:30860]
ENSG00000104973	15.87	15.38	14.74	14.16	16.54	14.81	0.027585189279488	5.21017420325698	0.739548917162529	0.932911572107251	19:49818278-49838816:+	MED25	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0035563,biological_process positive regulation of chromatin binding;GO:0042974,molecular_function retinoic acid receptor binding;GO:0044798,cellular_component nuclear transcription factor complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046965,molecular_function retinoid X receptor binding;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:2001178,biological_process positive regulation of mediator complex assembly	NA	mediator complex subunit 25 [Source:HGNC Symbol%3BAcc:HGNC:28845]
ENSG00000144355	2.21	3.74	4.42	5.08	2.97	3.12	-0.102231366062311	1.53106756566935	0.739610310247922	0.932911572107251	2:172084739-172089677:+	DLX1	32;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009954,biological_process proximal/distal pattern formation;GO:0021544,biological_process subpallium development;GO:0021766,biological_process hippocampus development;GO:0021879,biological_process forebrain neuron differentiation;GO:0021882,biological_process regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment;GO:0021892,biological_process cerebral cortex GABAergic interneuron differentiation;GO:0021893,biological_process cerebral cortex GABAergic interneuron fate commitment;GO:0030154,biological_process cell differentiation;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046533,biological_process negative regulation of photoreceptor cell differentiation;GO:0048706,biological_process embryonic skeletal system development;GO:0048715,biological_process negative regulation of oligodendrocyte differentiation;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071773,biological_process cellular response to BMP stimulus;GO:1902871,biological_process positive regulation of amacrine cell differentiation;GO:1903845,biological_process negative regulation of cellular response to transforming growth factor beta stimulus	NA	distal-less homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:2914]
ENSG00000162222	56.66	45.67	52.55	57.48	50.37	52.23	-0.0285281898676864	4.78625690774113	0.739809485274436	0.932915196983197	11:62728068-62740293:+	TTC9C	1;GO:0005515,molecular_function protein binding	NA	tetratricopeptide repeat domain 9C [Source:HGNC Symbol%3BAcc:HGNC:28432]
ENSG00000034713	128.41	129.23	102.87	124.86	127.55	118.46	-0.0315425466125606	5.42758081245867	0.73984182569209	0.932915196983197	16:75566350-75577881:+	GABARAPL2	27;GO:0000045,biological_process autophagosome assembly;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0000421,cellular_component autophagosome membrane;GO:0000422,biological_process mitophagy;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0006914,biological_process autophagy;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0008017,molecular_function microtubule binding;GO:0015031,biological_process protein transport;GO:0016236,biological_process macroautophagy;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0048487,molecular_function beta-tubulin binding;GO:0050811,molecular_function GABA receptor binding;GO:0051117,molecular_function ATPase binding;GO:0061024,biological_process membrane organization;GO:0097352,biological_process autophagosome maturation;GO:1901799,biological_process negative regulation of proteasomal protein catabolic process	GABARAP, ATG8, LC3; GABA(A) receptor-associated protein; K08341	GABA type A receptor associated protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:13291]
ENSG00000150054	0.71	0.48	0.78	1.04	0.34	0.82	-0.132268178214786	0.503663288421204	0.739997998718799	0.932915196983197	10:28050992-28334486:-	MPP7	17;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005912,cellular_component adherens junction;GO:0005923,cellular_component bicellular tight junction;GO:0009967,biological_process positive regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030010,biological_process establishment of cell polarity;GO:0030054,cellular_component cell junction;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0032947,molecular_function protein complex scaffold;GO:0035591,molecular_function signaling adaptor activity;GO:0045296,molecular_function cadherin binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0070830,biological_process bicellular tight junction assembly;GO:0071896,biological_process protein localization to adherens junction;GO:0097025,cellular_component MPP7-DLG1-LIN7 complex	NA	membrane palmitoylated protein 7 [Source:HGNC Symbol%3BAcc:HGNC:26542]
ENSG00000087995	11.90	14.24	14.34	13.14	13.91	14.82	-0.0435722993826223	3.97320239184054	0.740081207409149	0.932915196983197	17:62423866-62450822:+	METTL2A	5;GO:0008168,molecular_function methyltransferase activity;GO:0016427,molecular_function tRNA (cytosine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	methyltransferase like 2A [Source:HGNC Symbol%3BAcc:HGNC:25755]
ENSG00000111011	42.39	44.38	40.75	40.53	42.49	43.43	0.0212792743191296	5.86990573383701	0.740087064070407	0.932915196983197	12:122503457-122527000:-	RSRC2	1;GO:0003723,molecular_function RNA binding	NA	arginine and serine rich coiled-coil 2 [Source:HGNC Symbol%3BAcc:HGNC:30559]
ENSG00000258465	3.16	2.86	3.12	3.23	3.09	3.23	-0.0456561475897885	2.99541591473583	0.740114688561598	0.932915196983197	1:160217463-160285130:-	AL139011.2	4;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol	NA	NA
ENSG00000259753	0.57	0.65	0.66	0.54	0.87	0.66	-0.130880965799284	0.763478016285132	0.74015483249757	0.932915196983197	17:47253896-47344292:+	AC068234.1	11;GO:0004872,molecular_function receptor activity;GO:0007044,biological_process cell-substrate junction assembly;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030334,biological_process regulation of cell migration;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0070527,biological_process platelet aggregation	ITGB3, CD61; integrin beta 3; K06493	NA
ENSG00000153201	17.82	17.64	17.18	16.92	17.87	17.54	0.0201561660025729	7.40498803429219	0.740296765368865	0.932915196983197	2:108719480-108785811:+	RANBP2	53;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0001975,biological_process response to amphetamine;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005642,cellular_component annulate lamellae;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006457,biological_process protein folding;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0007051,biological_process spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0019789,molecular_function SUMO transferase activity;GO:0031965,cellular_component nuclear membrane;GO:0032403,molecular_function protein complex binding;GO:0033133,biological_process positive regulation of glucokinase activity;GO:0042405,cellular_component nuclear inclusion body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043657,cellular_component host cell;GO:0044614,cellular_component nuclear pore cytoplasmic filaments;GO:0044615,cellular_component nuclear pore nuclear basket;GO:0046604,biological_process positive regulation of mitotic centrosome separation;GO:0046872,molecular_function metal ion binding;GO:0046907,biological_process intracellular transport;GO:0051028,biological_process mRNA transport;GO:0051642,biological_process centrosome localization;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:0090526,biological_process regulation of gluconeogenesis involved in cellular glucose homeostasis;GO:1900034,biological_process regulation of cellular response to heat;GO:1990723,cellular_component cytoplasmic periphery of the nuclear pore complex	RANBP2, NUP358; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]; K12172	RAN binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9848]
ENSG00000109944	6.50	6.00	6.65	6.73	5.74	6.38	0.037937908652494	3.93805685052212	0.740350144826557	0.932915196983197	11:122882527-122959798:+	C11orf63	4;GO:0007420,biological_process brain development;GO:0032053,biological_process ciliary basal body organization;GO:0033326,biological_process cerebrospinal fluid secretion;GO:0035082,biological_process axoneme assembly	NA	chromosome 11 open reading frame 63 [Source:HGNC Symbol%3BAcc:HGNC:26288]
ENSG00000161618	5.61	5.40	4.71	4.92	5.61	4.88	0.0401133335455918	3.65816903217252	0.74037268738296	0.932915196983197	19:49453168-49471048:+	ALDH16A1	6;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	aldehyde dehydrogenase 16 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:28114]
ENSG00000063176	4.56	4.93	4.19	4.13	4.05	5.13	0.0419997450135083	3.35780015993231	0.740510436369786	0.932915196983197	19:48619290-48630717:+	SPHK2	30;GO:0000166,molecular_function nucleotide binding;GO:0001568,biological_process blood vessel development;GO:0003376,biological_process sphingosine-1-phosphate signaling pathway;GO:0003951,molecular_function NAD+ kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0006669,biological_process sphinganine-1-phosphate biosynthetic process;GO:0006670,biological_process sphingosine metabolic process;GO:0007420,biological_process brain development;GO:0007565,biological_process female pregnancy;GO:0008152,biological_process metabolic process;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008481,molecular_function sphinganine kinase activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017016,molecular_function Ras GTPase binding;GO:0017050,molecular_function D-erythro-sphingosine kinase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0038036,molecular_function sphingosine-1-phosphate receptor activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046512,biological_process sphingosine biosynthetic process;GO:0046834,biological_process lipid phosphorylation	SPHK; sphingosine kinase [EC:2.7.1.91]; K04718	sphingosine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:18859]
ENSG00000087301	6.14	6.93	6.02	5.76	7.87	6.17	-0.0452226493789483	4.02613607888927	0.740555583353276	0.932915196983197	14:52430589-52552522:-	TXNDC16	8;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0008150,biological_process biological_process;GO:0045454,biological_process cell redox homeostasis;GO:0070062,cellular_component extracellular exosome	NA	thioredoxin domain containing 16 [Source:HGNC Symbol%3BAcc:HGNC:19965]
ENSG00000213658	3.32	4.22	4.19	2.86	4.24	4.07	0.0717358557583605	2.01090410215698	0.740688040133854	0.932915196983197	16:28984825-28990783:+	LAT	34;GO:0000165,biological_process MAPK cascade;GO:0001772,cellular_component immunological synapse;GO:0002250,biological_process adaptive immune response;GO:0002260,biological_process lymphocyte homeostasis;GO:0002376,biological_process immune system process;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0008180,cellular_component COP9 signalosome;GO:0009967,biological_process positive regulation of signal transduction;GO:0010467,biological_process gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019722,biological_process calcium-mediated signaling;GO:0019901,molecular_function protein kinase binding;GO:0030168,biological_process platelet activation;GO:0035556,biological_process intracellular signal transduction;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042110,biological_process T cell activation;GO:0042629,cellular_component mast cell granule;GO:0043303,biological_process mast cell degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045121,cellular_component membrane raft;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0048872,biological_process homeostasis of number of cells;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050863,biological_process regulation of T cell activation	LAT; linker for activation of T cells; K07362	linker for activation of T-cells [Source:HGNC Symbol%3BAcc:HGNC:18874]
ENSG00000144485	2.26	1.34	2.43	2.99	1.14	2.53	-0.113403423113398	1.20323971436826	0.740793917064672	0.932915196983197	2:238238266-238240662:-	HES6	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0030154,biological_process cell differentiation;GO:0046983,molecular_function protein dimerization activity	HES2_6_7; hairy and enhancer of split 2/6/7; K09087	hes family bHLH transcription factor 6 [Source:HGNC Symbol%3BAcc:HGNC:18254]
ENSG00000130522	58.05	55.98	59.25	58.45	56.94	62.08	-0.0217018903696107	5.96811486316537	0.740877232467817	0.932915196983197	19:18279759-18281622:-	JUND	44;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002076,biological_process osteoblast development;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007568,biological_process aging;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0009314,biological_process response to radiation;GO:0009416,biological_process response to light stimulus;GO:0009612,biological_process response to mechanical stimulus;GO:0010941,biological_process regulation of cell death;GO:0014070,biological_process response to organic cyclic compound;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019899,molecular_function enzyme binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0032870,biological_process cellular response to hormone stimulus;GO:0032993,cellular_component protein-DNA complex;GO:0034097,biological_process response to cytokine;GO:0035976,cellular_component AP1 complex;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0043234,cellular_component protein complex;GO:0043434,biological_process response to peptide hormone;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051591,biological_process response to cAMP;GO:0051726,biological_process regulation of cell cycle;GO:0071277,biological_process cellular response to calcium ion	JUND; transcription factor jun-D; K04449	JunD proto-oncogene%2C AP-1 transcription factor subunit [Source:HGNC Symbol%3BAcc:HGNC:6206]
ENSG00000117751	29.51	28.22	31.87	29.93	26.72	31.92	0.0302517318459298	4.9764652708321	0.740930508628736	0.932915196983197	1:27830777-27851676:+	PPP1R8	27;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0004865,molecular_function protein serine/threonine phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006401,biological_process RNA catabolic process;GO:0008283,biological_process cell proliferation;GO:0008380,biological_process RNA splicing;GO:0008995,molecular_function ribonuclease E activity;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0035308,biological_process negative regulation of protein dephosphorylation;GO:0043086,biological_process negative regulation of catalytic activity;GO:0050790,biological_process regulation of catalytic activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis	NA	protein phosphatase 1 regulatory subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:9296]
ENSG00000100796	32.18	31.73	32.69	32.83	31.99	31.17	0.0215365301804804	6.33362669863583	0.740962453056182	0.932915196983197	14:91457610-91510554:-	PPP4R3A	5;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton	NA	protein phosphatase 4 regulatory subunit 3A [Source:HGNC Symbol%3BAcc:HGNC:20219]
ENSG00000162961	159.56	157.99	150.92	155.54	159.86	164.31	-0.0234543298631509	5.55815104539033	0.740965997507238	0.932915196983197	2:31867808-32039812:-	DPY30	20;GO:0000781,cellular_component chromosome, telomeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0006348,biological_process chromatin silencing at telomere;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016197,biological_process endosomal transport;GO:0016569,biological_process covalent chromatin modification;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0044666,cellular_component MLL3/4 complex;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation	NA	dpy-30%2C histone methyltransferase complex regulatory subunit [Source:HGNC Symbol%3BAcc:HGNC:24590]
ENSG00000176842	10.38	11.13	10.13	8.82	11.81	10.38	0.0379336809269725	4.0783261188347	0.741113244835384	0.933005954172579	16:54930861-54934485:+	IRX5	15;GO:0002027,biological_process regulation of heart rate;GO:0003677,molecular_function DNA binding;GO:0005499,molecular_function vitamin D binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007601,biological_process visual perception;GO:0008406,biological_process gonad development;GO:0010468,biological_process regulation of gene expression;GO:0042551,biological_process neuron maturation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048468,biological_process cell development;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0050896,biological_process response to stimulus;GO:0060040,biological_process retinal bipolar neuron differentiation	NA	iroquois homeobox 5 [Source:HGNC Symbol%3BAcc:HGNC:14361]
ENSG00000162636	2.81	4.84	2.86	3.93	4.05	3.12	-0.0910404624343261	2.02683752054823	0.741316152689866	0.933166758273938	1:108560088-108644900:+	FAM102B	NA	NA	family with sequence similarity 102 member B [Source:HGNC Symbol%3BAcc:HGNC:27637]
ENSG00000120159	24.68	24.97	27.22	26.23	25.35	24.51	0.0282183465247738	4.91782621582212	0.741532563332092	0.933344525313452	9:26840684-26892804:-	CAAP1	1;GO:0006915,biological_process apoptotic process	NA	caspase activity and apoptosis inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:25834]
ENSG00000104969	49.79	51.29	49.46	48.64	51.53	53.99	-0.0245838710804323	5.58077937635548	0.741639774591705	0.933384824293505	19:2754713-2783371:-	SGTA	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0043621,molecular_function protein self-association;GO:1903070,biological_process negative regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1903071,biological_process positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1904288,molecular_function BAT3 complex binding;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	NA	small glutamine rich tetratricopeptide repeat containing alpha [Source:HGNC Symbol%3BAcc:HGNC:10819]
ENSG00000148450	34.26	33.11	27.47	31.60	32.96	33.22	-0.0351215205768476	4.36027009565915	0.741799857685747	0.933491649782358	10:23095505-23122013:+	MSRB2	14;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003779,molecular_function actin binding;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006979,biological_process response to oxidative stress;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0030041,biological_process actin filament polymerization;GO:0030091,biological_process protein repair;GO:0033743,molecular_function peptide-methionine (R)-S-oxide reductase activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	methionine sulfoxide reductase B2 [Source:HGNC Symbol%3BAcc:HGNC:17061]
ENSG00000135018	61.95	63.87	67.89	64.87	64.08	63.47	0.0215979950804743	6.83222539123362	0.742013833093709	0.933534650839286	9:83659962-83708203:-	UBQLN1	31;GO:0000045,biological_process autophagosome assembly;GO:0000502,cellular_component proteasome complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016235,cellular_component aggresome;GO:0016236,biological_process macroautophagy;GO:0019900,molecular_function kinase binding;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031396,biological_process regulation of protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031593,molecular_function polyubiquitin binding;GO:0034140,biological_process negative regulation of toll-like receptor 3 signaling pathway;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035973,biological_process aggrephagy;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0071456,biological_process cellular response to hypoxia;GO:0097352,biological_process autophagosome maturation;GO:1901340,biological_process negative regulation of store-operated calcium channel activity;GO:1902175,biological_process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1903071,biological_process positive regulation of ER-associated ubiquitin-dependent protein catabolic process	UBQLN, DSK2; ubiquilin; K04523	ubiquilin 1 [Source:HGNC Symbol%3BAcc:HGNC:12508]
ENSG00000133874	4.71	5.55	3.64	4.03	3.10	5.75	0.0970815759461415	1.1487855034389	0.742061267008537	0.933534650839286	8:33547754-33567125:-	RNF122	9;GO:0000209,biological_process protein polyubiquitination;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 122 [Source:HGNC Symbol%3BAcc:HGNC:21147]
ENSG00000064999	6.14	5.96	5.17	6.21	5.68	5.91	-0.033970623327757	4.32505434599739	0.7421109188852	0.933534650839286	6:34889264-35091413:+	ANKS1A	11;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006929,biological_process substrate-dependent cell migration;GO:0016322,biological_process neuron remodeling;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:1901187,biological_process regulation of ephrin receptor signaling pathway	NA	ankyrin repeat and sterile alpha motif domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:20961]
ENSG00000165046	1.13	1.54	1.23	1.10	1.98	1.13	-0.110205752511223	1.10764784357588	0.742191678525961	0.933534650839286	8:38386206-38409527:+	LETM2	7;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006875,biological_process cellular metal ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043022,molecular_function ribosome binding	NA	leucine zipper and EF-hand containing transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:14648]
ENSG00000104081	10.11	8.83	10.80	11.12	9.07	11.21	-0.0586424920871558	2.53810240129849	0.742210059545067	0.933534650839286	15:40087889-40108892:-	BMF	16;GO:0001669,cellular_component acrosomal vesicle;GO:0001844,biological_process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0005515,molecular_function protein binding;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0010507,biological_process negative regulation of autophagy;GO:0016459,cellular_component myosin complex;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0034644,biological_process cellular response to UV;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043276,biological_process anoikis;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	BMF; Bcl-2-modifying factor; K17460	Bcl2 modifying factor [Source:HGNC Symbol%3BAcc:HGNC:24132]
ENSG00000198914	15.30	12.23	14.33	13.38	13.60	14.39	0.0373974690131299	4.3950456613884	0.742532158490491	0.933700747493572	2:104855510-104858574:+	POU3F3	28;GO:0001822,biological_process kidney development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0007588,biological_process excretion;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0021869,biological_process forebrain ventricular zone progenitor cell division;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048878,biological_process chemical homeostasis;GO:0071837,molecular_function HMG box domain binding;GO:0072218,biological_process metanephric ascending thin limb development;GO:0072227,biological_process metanephric macula densa development;GO:0072233,biological_process metanephric thick ascending limb development;GO:0072236,biological_process metanephric loop of Henle development;GO:0072240,biological_process metanephric DCT cell differentiation	NA	POU class 3 homeobox 3 [Source:HGNC Symbol%3BAcc:HGNC:9216]
ENSG00000188529	95.95	92.41	92.87	92.99	96.37	98.40	-0.0208230902220467	6.43344733097713	0.742562156307736	0.933700747493572	1:23964803-23980927:-	SRSF10	22;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016482,biological_process cytosolic transport;GO:0016607,cellular_component nuclear speck;GO:0043484,biological_process regulation of RNA splicing;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0050733,molecular_function RS domain binding;GO:0051082,molecular_function unfolded protein binding	FUSIP1; FUS-interacting serine-arginine-rich protein 1; K12900	serine and arginine rich splicing factor 10 [Source:HGNC Symbol%3BAcc:HGNC:16713]
ENSG00000151883	6.77	6.20	6.68	7.71	6.39	6.24	-0.0334287895635827	4.30735279731029	0.742567774047896	0.933700747493572	5:50665898-50846522:+	PARP8	4;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005622,cellular_component intracellular;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	poly(ADP-ribose) polymerase family member 8 [Source:HGNC Symbol%3BAcc:HGNC:26124]
ENSG00000106004	20.93	21.59	20.35	19.69	21.54	20.66	0.0318305370688381	4.08624503645188	0.742681750454862	0.933742462731321	7:27141051-27143668:-	HOXA5	44;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0002009,biological_process morphogenesis of an epithelium;GO:0003016,biological_process respiratory system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0007585,biological_process respiratory gaseous exchange;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010870,biological_process positive regulation of receptor biosynthetic process;GO:0016477,biological_process cell migration;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030324,biological_process lung development;GO:0030878,biological_process thyroid gland development;GO:0033599,biological_process regulation of mammary gland epithelial cell proliferation;GO:0035264,biological_process multicellular organism growth;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045639,biological_process positive regulation of myeloid cell differentiation;GO:0045647,biological_process negative regulation of erythrocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048286,biological_process lung alveolus development;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0060435,biological_process bronchiole development;GO:0060439,biological_process trachea morphogenesis;GO:0060441,biological_process epithelial tube branching involved in lung morphogenesis;GO:0060480,biological_process lung goblet cell differentiation;GO:0060481,biological_process lobar bronchus epithelium development;GO:0060484,biological_process lung-associated mesenchyme development;GO:0060535,biological_process trachea cartilage morphogenesis;GO:0060536,biological_process cartilage morphogenesis;GO:0060574,biological_process intestinal epithelial cell maturation;GO:0060638,biological_process mesenchymal-epithelial cell signaling;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0060749,biological_process mammary gland alveolus development;GO:0060764,biological_process cell-cell signaling involved in mammary gland development	NA	homeobox A5 [Source:HGNC Symbol%3BAcc:HGNC:5106]
ENSG00000080822	150.66	146.48	157.88	155.85	154.02	155.52	-0.019988665361514	7.27248511495459	0.74278685625257	0.933742462731321	3:98497911-98523066:-	CLDND1	4;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane	NA	claudin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:1322]
ENSG00000120093	26.28	25.72	26.27	26.91	25.01	28.34	-0.0244199212852979	5.45275482994637	0.743073208347726	0.933742462731321	17:48548869-48604912:-	HOXB3	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0021546,biological_process rhombomere development;GO:0021615,biological_process glossopharyngeal nerve morphogenesis;GO:0030878,biological_process thyroid gland development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0050767,biological_process regulation of neurogenesis;GO:0051216,biological_process cartilage development;GO:0060216,biological_process definitive hemopoiesis;GO:0060324,biological_process face development	NA	homeobox B3 [Source:HGNC Symbol%3BAcc:HGNC:5114]
ENSG00000196172	1.82	1.53	1.33	1.74	1.92	1.34	-0.0741750864232637	1.71407729308629	0.743334983843247	0.933742462731321	19:23739194-23758891:-	ZNF681	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 681 [Source:HGNC Symbol%3BAcc:HGNC:26457]
ENSG00000105270	1.85	2.39	2.29	2.05	1.94	2.23	0.0658168819678894	1.85790367413358	0.74339997034616	0.933742462731321	19:36014659-36033343:-	CLIP3	25;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008017,molecular_function microtubule binding;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0010828,biological_process positive regulation of glucose transport;GO:0016020,cellular_component membrane;GO:0018230,biological_process peptidyl-L-cysteine S-palmitoylation;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0031901,cellular_component early endosome membrane;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035594,molecular_function ganglioside binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0044091,biological_process membrane biogenesis;GO:0045121,cellular_component membrane raft;GO:0045444,biological_process fat cell differentiation;GO:0045807,biological_process positive regulation of endocytosis;GO:0055038,cellular_component recycling endosome membrane;GO:0072321,biological_process chaperone-mediated protein transport;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane	NA	CAP-Gly domain containing linker protein 3 [Source:HGNC Symbol%3BAcc:HGNC:24314]
ENSG00000142961	8.96	6.18	6.68	7.45	6.13	7.61	0.0659829855013226	2.57472588868087	0.743402320237885	0.933742462731321	1:46607714-46616891:-	MOB3C	2;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	MOB kinase activator 3C [Source:HGNC Symbol%3BAcc:HGNC:29800]
ENSG00000158406	4.57	5.57	6.19	5.33	5.40	4.32	0.127060048536486	0.816660307358706	0.743408152165221	0.933742462731321	6:26277608-26285638:-	HIST1H4H	36;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000228,cellular_component nuclear chromosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000786,cellular_component nucleosome;GO:0000788,cellular_component nuclear nucleosome;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006334,biological_process nucleosome assembly;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0016020,cellular_component membrane;GO:0016233,biological_process telomere capping;GO:0019904,molecular_function protein domain specific binding;GO:0031012,cellular_component extracellular matrix;GO:0032200,biological_process telomere organization;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0042393,molecular_function histone binding;GO:0043234,cellular_component protein complex;GO:0044267,biological_process cellular protein metabolic process;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045653,biological_process negative regulation of megakaryocyte differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046982,molecular_function protein heterodimerization activity;GO:0051290,biological_process protein heterotetramerization;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070062,cellular_component extracellular exosome;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904837,biological_process beta-catenin-TCF complex assembly	NA	histone cluster 1 H4 family member h [Source:HGNC Symbol%3BAcc:HGNC:4788]
ENSG00000176386	92.78	101.56	96.98	98.36	95.47	93.76	0.0263901146707656	4.62852012375275	0.743413550353814	0.933742462731321	9:113255834-113275589:-	CDC26	16;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC12, CDC26; anaphase-promoting complex subunit 12; K03359	cell division cycle 26 [Source:HGNC Symbol%3BAcc:HGNC:17839]
ENSG00000164327	5.75	6.11	6.19	6.14	6.12	6.25	-0.0266526999340131	4.99176655313276	0.743819418865828	0.933742462731321	5:38937918-39074408:-	RICTOR	31;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0008047,molecular_function enzyme activator activity;GO:0009790,biological_process embryo development;GO:0010468,biological_process regulation of gene expression;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030010,biological_process establishment of cell polarity;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0030950,biological_process establishment or maintenance of actin cytoskeleton polarity;GO:0031295,biological_process T cell costimulation;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031929,biological_process TOR signaling;GO:0031932,cellular_component TORC2 complex;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0033135,biological_process regulation of peptidyl-serine phosphorylation;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042325,biological_process regulation of phosphorylation;GO:0043022,molecular_function ribosome binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043087,biological_process regulation of GTPase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050727,biological_process regulation of inflammatory response;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051896,biological_process regulation of protein kinase B signaling;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:2000114,biological_process regulation of establishment of cell polarity	RICTOR; rapamycin-insensitive companion of mTOR; K08267	RPTOR independent companion of MTOR complex 2 [Source:HGNC Symbol%3BAcc:HGNC:28611]
ENSG00000139436	10.61	10.18	10.93	10.14	10.18	11.05	0.0291429527270243	4.61340944595316	0.743821632974757	0.933742462731321	12:109929791-109996389:-	GIT2	9;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005925,cellular_component focal adhesion;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	GIT2; G protein-coupled receptor kinase interactor 2; K12487	GIT ArfGAP 2 [Source:HGNC Symbol%3BAcc:HGNC:4273]
ENSG00000121058	12.14	13.60	12.53	11.76	15.45	12.33	-0.0383843973683598	4.51756762243499	0.743878680109409	0.933742462731321	17:56938186-56961054:-	COIL	10;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0008022,molecular_function protein C-terminus binding;GO:0015030,cellular_component Cajal body;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0042802,molecular_function identical protein binding	NA	coilin [Source:HGNC Symbol%3BAcc:HGNC:2184]
ENSG00000080815	36.76	36.70	36.14	38.43	36.28	37.40	-0.0213495270038523	5.9466341425654	0.743935589516055	0.933742462731321	14:73136417-73223691:+	PSEN1	150;GO:0000045,biological_process autophagosome assembly;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000139,cellular_component Golgi membrane;GO:0000186,biological_process activation of MAPKK activity;GO:0000776,cellular_component kinetochore;GO:0001568,biological_process blood vessel development;GO:0001708,biological_process cell fate specification;GO:0001756,biological_process somitogenesis;GO:0001764,biological_process neuron migration;GO:0001921,biological_process positive regulation of receptor recycling;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001947,biological_process heart looping;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002265,biological_process astrocyte activation involved in immune response;GO:0002286,biological_process T cell activation involved in immune response;GO:0002573,biological_process myeloid leukocyte differentiation;GO:0003407,biological_process neural retina development;GO:0004175,molecular_function endopeptidase activity;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005640,cellular_component nuclear outer membrane;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006486,biological_process protein glycosylation;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0006839,biological_process mitochondrial transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007155,biological_process cell adhesion;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0007176,biological_process regulation of epidermal growth factor-activated receptor activity;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007611,biological_process learning or memory;GO:0007613,biological_process memory;GO:0008013,molecular_function beta-catenin binding;GO:0008233,molecular_function peptidase activity;GO:0009791,biological_process post-embryonic development;GO:0009986,cellular_component cell surface;GO:0015031,biological_process protein transport;GO:0015813,biological_process L-glutamate transport;GO:0015871,biological_process choline transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016080,biological_process synaptic vesicle targeting;GO:0016235,cellular_component aggresome;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0021795,biological_process cerebral cortex cell migration;GO:0021870,biological_process Cajal-Retzius cell differentiation;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021987,biological_process cerebral cortex development;GO:0022008,biological_process neurogenesis;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0030182,biological_process neuron differentiation;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030900,biological_process forebrain development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031594,cellular_component neuromuscular junction;GO:0031965,cellular_component nuclear membrane;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0034205,biological_process beta-amyloid formation;GO:0035253,cellular_component ciliary rootlet;GO:0035282,biological_process segmentation;GO:0035556,biological_process intracellular signal transduction;GO:0035577,cellular_component azurophil granule membrane;GO:0040011,biological_process locomotion;GO:0042325,biological_process regulation of phosphorylation;GO:0042500,molecular_function aspartic endopeptidase activity, intramembrane cleaving;GO:0042982,biological_process amyloid precursor protein metabolic process;GO:0042987,biological_process amyloid precursor protein catabolic process;GO:0043005,cellular_component neuron projection;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043198,cellular_component dendritic shaft;GO:0043227,cellular_component membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043393,biological_process regulation of protein binding;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043589,biological_process skin morphogenesis;GO:0044267,biological_process cellular protein metabolic process;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048143,biological_process astrocyte activation;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048538,biological_process thymus development;GO:0048666,biological_process neuron development;GO:0048705,biological_process skeletal system morphogenesis;GO:0048854,biological_process brain morphogenesis;GO:0050435,biological_process beta-amyloid metabolic process;GO:0050673,biological_process epithelial cell proliferation;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050808,biological_process synapse organization;GO:0050820,biological_process positive regulation of coagulation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051402,biological_process neuron apoptotic process;GO:0051444,biological_process negative regulation of ubiquitin-protein transferase activity;GO:0051563,biological_process smooth endoplasmic reticulum calcium ion homeostasis;GO:0051604,biological_process protein maturation;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060075,biological_process regulation of resting membrane potential;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0070588,biological_process calcium ion transmembrane transport;GO:0070765,cellular_component gamma-secretase complex;GO:0090647,biological_process modulation of age-related behavioral decline;GO:0098793,cellular_component presynapse;GO:1904646,biological_process cellular response to beta-amyloid;GO:1904797,biological_process negative regulation of core promoter binding;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	PSEN1, PS1; presenilin 1 [EC:3.4.23.-]; K04505	presenilin 1 [Source:HGNC Symbol%3BAcc:HGNC:9508]
ENSG00000114902	171.20	192.83	172.03	186.81	184.59	177.39	-0.0246075996614641	6.52055535157067	0.744022863788265	0.933742462731321	3:52704954-52711146:+	SPCS1	16;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005787,cellular_component signal peptidase complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006465,biological_process signal peptide processing;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0031090,cellular_component organelle membrane;GO:0043022,molecular_function ribosome binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045047,biological_process protein targeting to ER	SPCS1; signal peptidase complex subunit 1 [EC:3.4.-.-]; K12946	signal peptidase complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:23401]
ENSG00000144426	2.45	2.25	2.70	2.66	2.49	2.51	-0.0296816415353832	4.36147196370018	0.744026455389944	0.933742462731321	2:203014878-203226378:+	NBEAL1	NA	NA	neurobeachin like 1 [Source:HGNC Symbol%3BAcc:HGNC:20681]
ENSG00000148308	31.26	32.49	31.47	32.28	33.39	31.76	-0.0226731047304599	5.73705191722041	0.744030844261471	0.933742462731321	9:133030674-133058503:+	GTF3C5	15;GO:0000127,cellular_component transcription factor TFIIIC complex;GO:0000999,biological_process RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly;GO:0001002,molecular_function RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003,molecular_function RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0001005,molecular_function transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting;GO:0001009,biological_process transcription from RNA polymerase III type 2 promoter;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0042791,biological_process 5S class rRNA transcription from RNA polymerase III type 1 promoter;GO:0042797,biological_process tRNA transcription from RNA polymerase III promoter	NA	general transcription factor IIIC subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:4668]
ENSG00000183248	0.21	0.50	0.33	0.32	0.41	0.40	-0.161665222523324	0.664238914747423	0.744036781028787	0.933742462731321	19:7868718-7874379:-	PRR36	NA	NA	proline rich 36 [Source:HGNC Symbol%3BAcc:HGNC:26172]
ENSG00000165898	43.77	48.18	44.69	41.53	43.34	49.64	0.0282563817260222	4.43634609443717	0.744063488247176	0.933742462731321	14:74493719-74497106:+	ISCA2	13;GO:0005198,molecular_function structural molecule activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0044281,biological_process small molecule metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0051604,biological_process protein maturation;GO:0097428,biological_process protein maturation by iron-sulfur cluster transfer	NA	iron-sulfur cluster assembly 2 [Source:HGNC Symbol%3BAcc:HGNC:19857]
ENSG00000008853	2.47	2.96	1.96	2.69	2.42	1.96	0.0644588680683269	2.47136493751448	0.744067224205939	0.933742462731321	8:22987416-23020199:+	RHOBTB2	9;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	RHOBTB1_2; Rho-related BTB domain-containing protein 1/2; K07868	Rho related BTB domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:18756]
ENSG00000142039	14.07	15.34	12.88	12.62	13.03	15.76	0.0341254156601302	4.12354727474619	0.744104901861126	0.933742462731321	19:41310188-41324883:+	CCDC97	1;GO:0005686,cellular_component U2 snRNP	NA	coiled-coil domain containing 97 [Source:HGNC Symbol%3BAcc:HGNC:28289]
ENSG00000262814	2.38	3.22	2.11	2.39	2.81	3.20	-0.14338985941792	0.795743211627701	0.744140908463989	0.933742462731321	17:81703356-81707526:+	MRPL12	14;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12; K02935	mitochondrial ribosomal protein L12 [Source:HGNC Symbol%3BAcc:HGNC:10378]
ENSG00000160445	17.12	14.68	17.17	16.39	16.30	15.88	0.029792160192832	5.23247875314041	0.744180631902115	0.933742462731321	9:128729785-128772414:-	ZER1	4;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0051438,biological_process regulation of ubiquitin-protein transferase activity	NA	zyg-11 related cell cycle regulator [Source:HGNC Symbol%3BAcc:HGNC:30960]
ENSG00000129007	4.20	4.23	6.38	5.35	3.61	5.14	0.0893208920009266	1.58533431755303	0.744361600238066	0.933834669564038	15:68190704-68206110:-	CALML4	1;GO:0005509,molecular_function calcium ion binding	NA	calmodulin like 4 [Source:HGNC Symbol%3BAcc:HGNC:18445]
ENSG00000126391	5.21	5.08	4.40	4.88	5.69	3.60	0.0658698296488164	2.88128905175562	0.744404580305821	0.933834669564038	11:65386598-65413525:+	FRMD8	2;GO:0005515,molecular_function protein binding;GO:0005856,cellular_component cytoskeleton	NA	FERM domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:25462]
ENSG00000189164	2.02	2.37	2.83	2.77	2.52	2.34	-0.0682806832464541	2.44241538445262	0.744488986150079	0.933846178767273	19:37371060-37393066:+	ZNF527	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 527 [Source:HGNC Symbol%3BAcc:HGNC:29385]
ENSG00000184254	4.50	5.11	4.90	4.64	4.83	5.60	-0.0521728537921567	3.14037958119635	0.744584799541125	0.93385165655055	15:100877713-100916626:+	ALDH1A3	32;GO:0001758,molecular_function retinal dehydrogenase activity;GO:0002072,biological_process optic cup morphogenesis involved in camera-type eye development;GO:0002138,biological_process retinoic acid biosynthetic process;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0004030,molecular_function aldehyde dehydrogenase [NAD(P)+] activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007626,biological_process locomotory behavior;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0021768,biological_process nucleus accumbens development;GO:0031076,biological_process embryonic camera-type eye development;GO:0042472,biological_process inner ear morphogenesis;GO:0042572,biological_process retinol metabolic process;GO:0042573,biological_process retinoic acid metabolic process;GO:0042574,biological_process retinal metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043584,biological_process nose development;GO:0048048,biological_process embryonic eye morphogenesis;GO:0050885,biological_process neuromuscular process controlling balance;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0060013,biological_process righting reflex;GO:0060166,biological_process olfactory pit development;GO:0060324,biological_process face development;GO:0070062,cellular_component extracellular exosome;GO:0070324,molecular_function thyroid hormone binding;GO:0070384,biological_process Harderian gland development;GO:0070403,molecular_function NAD+ binding	E1.2.1.5; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]; K00129	aldehyde dehydrogenase 1 family member A3 [Source:HGNC Symbol%3BAcc:HGNC:409]
ENSG00000188659	0.75	0.54	0.78	0.53	0.75	0.65	0.138695898218556	0.139818454104136	0.74464381668713	0.93385165655055	15:82262809-82284930:+	SAXO2	1;GO:0008017,molecular_function microtubule binding	NA	stabilizer of axonemal microtubules 2 [Source:HGNC Symbol%3BAcc:HGNC:33727]
ENSG00000181472	11.54	10.29	11.41	11.75	10.53	12.08	-0.0313612784041771	4.13576307837426	0.744918963616935	0.934102343204063	6:151364116-151391548:-	ZBTB2	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:20868]
ENSG00000174607	46.56	52.64	48.52	45.72	52.71	47.88	0.0235868201023645	6.31583258749364	0.745002064207439	0.934112184142115	4:114598454-114678224:+	UGT8	21;GO:0002175,biological_process protein localization to paranode region of axon;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006682,biological_process galactosylceramide biosynthetic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0007010,biological_process cytoskeleton organization;GO:0007417,biological_process central nervous system development;GO:0007422,biological_process peripheral nervous system development;GO:0008152,biological_process metabolic process;GO:0008489,molecular_function UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0030913,biological_process paranodal junction assembly;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0047263,molecular_function N-acylsphingosine galactosyltransferase activity;GO:0048812,biological_process neuron projection morphogenesis	CGT, UGT8; ceramide galactosyltransferase [EC:2.4.1.47]; K04628	UDP glycosyltransferase 8 [Source:HGNC Symbol%3BAcc:HGNC:12555]
ENSG00000131037	1.44	1.60	1.38	1.19	1.39	1.64	0.0654471188445852	1.84727907091588	0.745574330563414	0.93463057834546	19:55072019-55087923:+	EPS8L1	17;GO:0003779,molecular_function actin binding;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007266,biological_process Rho protein signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0032587,cellular_component ruffle membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042608,molecular_function T cell receptor binding;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:1900029,biological_process positive regulation of ruffle assembly	NA	EPS8 like 1 [Source:HGNC Symbol%3BAcc:HGNC:21295]
ENSG00000159110	20.17	17.63	19.64	20.64	17.91	18.34	0.0306223354195529	5.12605983859433	0.745668194483728	0.93463057834546	21:33229900-33265675:+	IFNAR2	20;GO:0004905,molecular_function type I interferon receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007259,biological_process JAK-STAT cascade;GO:0008283,biological_process cell proliferation;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding;GO:0035455,biological_process response to interferon-alpha;GO:0035456,biological_process response to interferon-beta;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway	IFNAR2; interferon receptor 2; K05131	interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:5433]
ENSG00000084731	5.42	4.90	4.56	5.04	5.29	4.24	0.0463050215446768	3.59868836130002	0.745692320441982	0.93463057834546	2:25926595-25982749:-	KIF3C	18;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0072384,biological_process organelle transport along microtubule;GO:0097542,cellular_component ciliary tip	KIF3A; kinesin family member 3A; K10394	kinesin family member 3C [Source:HGNC Symbol%3BAcc:HGNC:6321]
ENSG00000156017	10.16	11.04	11.26	11.17	9.75	10.92	0.0360072018485879	3.82332243413864	0.745716687983036	0.93463057834546	9:74981019-75028423:-	CARNMT1	9;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006548,biological_process histidine catabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030735,molecular_function carnosine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0035498,biological_process carnosine metabolic process	NA	carnosine N-methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:23435]
ENSG00000114480	116.80	126.27	112.86	115.44	124.43	113.42	0.0218049535359968	7.97470805768048	0.745865628990071	0.934686595144574	3:81489698-81762161:-	GBE1	14;GO:0003824,molecular_function catalytic activity;GO:0003844,molecular_function 1,4-alpha-glucan branching enzyme activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030246,molecular_function carbohydrate binding;GO:0043169,molecular_function cation binding;GO:0070062,cellular_component extracellular exosome	GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]; K00700	1%2C4-alpha-glucan branching enzyme 1 [Source:HGNC Symbol%3BAcc:HGNC:4180]
ENSG00000003402	33.69	28.55	30.38	30.65	29.90	34.61	-0.024860002000763	6.00414831691968	0.745984955374572	0.934686595144574	2:201116103-201176687:+	CFLAR	51;GO:0001666,biological_process response to hypoxia;GO:0002020,molecular_function protease binding;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005123,molecular_function death receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0007519,biological_process skeletal muscle tissue development;GO:0008047,molecular_function enzyme activator activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014732,biological_process skeletal muscle atrophy;GO:0014842,biological_process regulation of skeletal muscle satellite cell proliferation;GO:0014866,biological_process skeletal myofibril assembly;GO:0016032,biological_process viral process;GO:0031264,cellular_component death-inducing signaling complex;GO:0031265,cellular_component CD95 death-inducing signaling complex;GO:0032403,molecular_function protein complex binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033574,biological_process response to testosterone;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0045121,cellular_component membrane raft;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060544,biological_process regulation of necroptotic process;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071392,biological_process cellular response to estradiol stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0071732,biological_process cellular response to nitric oxide;GO:0072126,biological_process positive regulation of glomerular mesangial cell proliferation;GO:0097194,biological_process execution phase of apoptosis;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:0097342,cellular_component ripoptosome;GO:1901740,biological_process negative regulation of myoblast fusion;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903055,biological_process positive regulation of extracellular matrix organization;GO:1903427,biological_process negative regulation of reactive oxygen species biosynthetic process;GO:1903845,biological_process negative regulation of cellular response to transforming growth factor beta stimulus;GO:1903944,biological_process negative regulation of hepatocyte apoptotic process;GO:1904036,biological_process negative regulation of epithelial cell apoptotic process;GO:2000347,biological_process positive regulation of hepatocyte proliferation;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator; K04724	CASP8 and FADD like apoptosis regulator [Source:HGNC Symbol%3BAcc:HGNC:1876]
ENSG00000158528	3.95	3.87	3.18	3.34	4.15	3.90	-0.0417025681903649	3.96567069846771	0.746108399112878	0.934686595144574	7:94907201-95296415:+	PPP1R9A	51;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007568,biological_process aging;GO:0008022,molecular_function protein C-terminus binding;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0019722,biological_process calcium-mediated signaling;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030175,cellular_component filopodium;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030833,biological_process regulation of actin filament polymerization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031175,biological_process neuron projection development;GO:0031594,cellular_component neuromuscular junction;GO:0032403,molecular_function protein complex binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0044325,molecular_function ion channel binding;GO:0044326,cellular_component dendritic spine neck;GO:0045202,cellular_component synapse;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0048666,biological_process neuron development;GO:0051015,molecular_function actin filament binding;GO:0051020,molecular_function GTPase binding;GO:0051489,biological_process regulation of filopodium assembly;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0051823,biological_process regulation of synapse structural plasticity;GO:0051963,biological_process regulation of synapse assembly;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0097237,biological_process cellular response to toxic substance;GO:1900272,biological_process negative regulation of long-term synaptic potentiation;GO:1900454,biological_process positive regulation of long term synaptic depression;GO:1904049,biological_process negative regulation of spontaneous neurotransmitter secretion;GO:1990761,cellular_component growth cone lamellipodium	NA	protein phosphatase 1 regulatory subunit 9A [Source:HGNC Symbol%3BAcc:HGNC:14946]
ENSG00000183853	53.75	52.91	55.45	54.95	58.48	52.52	-0.021255439841882	6.98916882040587	0.74618920140596	0.934686595144574	1:157993272-158100262:+	KIRREL1	17;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007411,biological_process axon guidance;GO:0007588,biological_process excretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0017022,molecular_function myosin binding;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031253,cellular_component cell projection membrane;GO:0031295,biological_process T cell costimulation;GO:0043198,cellular_component dendritic shaft;GO:0045121,cellular_component membrane raft;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	kirre like nephrin family adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:15734]
ENSG00000205517	11.27	14.42	17.33	15.44	12.90	13.76	0.0420797654765514	4.96210156538706	0.746206005769153	0.934686595144574	19:11384340-11419342:-	RGL3	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005622,cellular_component intracellular;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008321,molecular_function Ral guanyl-nucleotide exchange factor activity;GO:0017016,molecular_function Ras GTPase binding;GO:0031267,molecular_function small GTPase binding;GO:0043547,biological_process positive regulation of GTPase activity	NA	ral guanine nucleotide dissociation stimulator like 3 [Source:HGNC Symbol%3BAcc:HGNC:30282]
ENSG00000188566	7.81	7.46	7.65	7.54	7.55	7.50	0.0353597404682731	3.80292427686333	0.746232117464583	0.934686595144574	9:137205684-137217009:+	NDOR1	14;GO:0003958,molecular_function NADPH-hemoprotein reductase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008219,biological_process cell death;GO:0010181,molecular_function FMN binding;GO:0016491,molecular_function oxidoreductase activity;GO:0036245,biological_process cellular response to menadione;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process	NA	NADPH dependent diflavin oxidoreductase 1 [Source:HGNC Symbol%3BAcc:HGNC:29838]
ENSG00000154001	27.12	30.83	27.84	31.48	27.01	29.51	-0.029598819813328	5.34730718360389	0.746289566953543	0.934686595144574	14:63371356-63543374:-	PPP2R5E	7;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0050790,biological_process regulation of catalytic activity	PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'; K11584	protein phosphatase 2 regulatory subunit B'epsilon [Source:HGNC Symbol%3BAcc:HGNC:9313]
ENSG00000166321	2.36	2.22	2.12	2.85	2.04	2.29	-0.086009163631208	1.4044390296256	0.746363774355355	0.934686595144574	10:73110374-73131828:+	NUDT13	6;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016462,molecular_function pyrophosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	nudix hydrolase 13 [Source:HGNC Symbol%3BAcc:HGNC:18827]
ENSG00000121769	3.87	2.28	3.15	4.99	2.17	3.18	-0.114162946499075	0.627107670189376	0.746631830264394	0.93478954387307	1:31365624-31376850:-	FABP3	28;GO:0005215,molecular_function transporter activity;GO:0005324,molecular_function long-chain fatty acid transporter activity;GO:0005504,molecular_function fatty acid binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006631,biological_process fatty acid metabolic process;GO:0006810,biological_process transport;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0015909,biological_process long-chain fatty acid transport;GO:0016528,cellular_component sarcoplasm;GO:0019433,biological_process triglyceride catabolic process;GO:0032868,biological_process response to insulin;GO:0036041,molecular_function long-chain fatty acid binding;GO:0042493,biological_process response to drug;GO:0042632,biological_process cholesterol homeostasis;GO:0044539,biological_process long-chain fatty acid import;GO:0046320,biological_process regulation of fatty acid oxidation;GO:0050543,molecular_function icosatetraenoic acid binding;GO:0055091,biological_process phospholipid homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0070538,molecular_function oleic acid binding;GO:0070542,biological_process response to fatty acid;GO:0071073,biological_process positive regulation of phospholipid biosynthetic process;GO:2001245,biological_process regulation of phosphatidylcholine biosynthetic process	FABP3; fatty acid-binding protein 3, muscle and heart; K08752	fatty acid binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:3557]
ENSG00000104368	0.80	0.40	0.35	0.67	0.27	0.46	0.181633086190837	-0.0179167094145905	0.746866496174264	0.93478954387307	8:42175232-42207724:-	PLAT	23;GO:0001666,biological_process response to hypoxia;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0007596,biological_process blood coagulation;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009986,cellular_component cell surface;GO:0014909,biological_process smooth muscle cell migration;GO:0016787,molecular_function hydrolase activity;GO:0030141,cellular_component secretory granule;GO:0031639,biological_process plasminogen activation;GO:0042730,biological_process fibrinolysis;GO:0045177,cellular_component apical part of cell;GO:0045861,biological_process negative regulation of proteolysis;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0051219,molecular_function phosphoprotein binding;GO:0070062,cellular_component extracellular exosome	PLAT; tissue plasminogen activator [EC:3.4.21.68]; K01343	plasminogen activator%2C tissue type [Source:HGNC Symbol%3BAcc:HGNC:9051]
ENSG00000100523	4.83	4.36	5.25	5.50	5.35	4.16	-0.0374919086203485	3.75867331586386	0.746912801564435	0.93478954387307	14:53036744-53153282:-	DDHD1	9;GO:0004620,molecular_function phospholipase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090141,biological_process positive regulation of mitochondrial fission	NA	DDHD domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19714]
ENSG00000156253	21.99	20.57	18.23	22.30	19.81	20.65	-0.0344391733854879	4.31267277148465	0.747049387603135	0.93478954387307	21:29004383-29019378:-	RWDD2B	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	RWD domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:1302]
ENSG00000173065	5.08	7.25	5.63	6.49	6.14	6.01	-0.0574355208524842	3.4407556222227	0.747052647857825	0.93478954387307	17:28755977-28855232:-	FAM222B	1;GO:0005654,cellular_component nucleoplasm	NA	family with sequence similarity 222 member B [Source:HGNC Symbol%3BAcc:HGNC:25563]
ENSG00000139233	69.17	70.62	63.90	65.97	63.30	71.77	0.0265833288066908	4.71464048097328	0.747164115797649	0.93478954387307	12:66116554-66130768:-	LLPH	7;GO:0001099,molecular_function basal RNA polymerase II transcription machinery binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0060999,biological_process positive regulation of dendritic spine development;GO:0097484,biological_process dendrite extension	NA	LLP homolog%2C long-term synaptic facilitation [Source:HGNC Symbol%3BAcc:HGNC:28229]
ENSG00000140463	12.67	12.63	11.95	12.98	10.98	12.79	0.0290792633681326	4.62664599289174	0.747209535417377	0.93478954387307	15:72686178-72738476:+	BBS4	83;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000242,cellular_component pericentriolar material;GO:0000281,biological_process mitotic cytokinesis;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0001764,biological_process neuron migration;GO:0001843,biological_process neural tube closure;GO:0001895,biological_process retina homeostasis;GO:0001917,cellular_component photoreceptor inner segment;GO:0001947,biological_process heart looping;GO:0003085,biological_process negative regulation of systemic arterial blood pressure;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007098,biological_process centrosome cycle;GO:0007286,biological_process spermatid development;GO:0007601,biological_process visual perception;GO:0007608,biological_process sensory perception of smell;GO:0008104,biological_process protein localization;GO:0010629,biological_process negative regulation of gene expression;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016358,biological_process dendrite development;GO:0019216,biological_process regulation of lipid metabolic process;GO:0021591,biological_process ventricular system development;GO:0021756,biological_process striatum development;GO:0021766,biological_process hippocampus development;GO:0021987,biological_process cerebral cortex development;GO:0030030,biological_process cell projection organization;GO:0030534,biological_process adult behavior;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0031514,cellular_component motile cilium;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0032402,biological_process melanosome transport;GO:0032465,biological_process regulation of cytokinesis;GO:0033210,biological_process leptin-mediated signaling pathway;GO:0033365,biological_process protein localization to organelle;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034451,cellular_component centriolar satellite;GO:0034452,molecular_function dynactin binding;GO:0034454,biological_process microtubule anchoring at centrosome;GO:0034464,cellular_component BBSome;GO:0035176,biological_process social behavior;GO:0035845,biological_process photoreceptor cell outer segment organization;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0038108,biological_process negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042995,cellular_component cell projection;GO:0043014,molecular_function alpha-tubulin binding;GO:0044321,biological_process response to leptin;GO:0045444,biological_process fat cell differentiation;GO:0045494,biological_process photoreceptor cell maintenance;GO:0045724,biological_process positive regulation of cilium assembly;GO:0046548,biological_process retinal rod cell development;GO:0046907,biological_process intracellular transport;GO:0048487,molecular_function beta-tubulin binding;GO:0048854,biological_process brain morphogenesis;GO:0050893,biological_process sensory processing;GO:0050896,biological_process response to stimulus;GO:0051457,biological_process maintenance of protein location in nucleus;GO:0051492,biological_process regulation of stress fiber assembly;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0060296,biological_process regulation of cilium beat frequency involved in ciliary motility;GO:0060324,biological_process face development;GO:0060613,biological_process fat pad development;GO:0061512,biological_process protein localization to cilium;GO:0071539,biological_process protein localization to centrosome;GO:0097730,cellular_component non-motile cilium;GO:1902855,biological_process regulation of nonmotile primary cilium assembly;GO:1903546,biological_process protein localization to photoreceptor outer segment;GO:1905515,biological_process non-motile cilium assembly	NA	Bardet-Biedl syndrome 4 [Source:HGNC Symbol%3BAcc:HGNC:969]
ENSG00000005379	0.28	0.20	0.35	0.21	0.33	0.23	0.143857763734103	0.762760590323446	0.747241715808135	0.93478954387307	17:58301227-58328760:-	TSPOAP1	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0007269,biological_process neurotransmitter secretion;GO:0008150,biological_process biological_process;GO:0014047,biological_process glutamate secretion;GO:0030156,molecular_function benzodiazepine receptor binding;GO:0098793,cellular_component presynapse	NA	TSPO associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16831]
ENSG00000166012	77.90	73.20	85.70	82.87	67.46	83.83	0.029101081860054	6.40625439192745	0.747251171844239	0.93478954387307	11:93729947-93784391:-	TAF1D	12;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005668,cellular_component RNA polymerase transcription factor SL1 complex;GO:0005815,cellular_component microtubule organizing center;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0045815,biological_process positive regulation of gene expression, epigenetic	NA	TATA-box binding protein associated factor%2C RNA polymerase I subunit D [Source:HGNC Symbol%3BAcc:HGNC:28759]
ENSG00000034677	27.59	23.76	26.91	25.14	25.10	27.44	0.0256693621148597	6.03576098703841	0.747361292034541	0.93478954387307	8:100257059-100336218:-	RNF19A	19;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008134,molecular_function transcription factor binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 19A%2C RBR E3 ubiquitin protein ligase [Source:HGNC Symbol%3BAcc:HGNC:13432]
ENSG00000132604	11.49	13.59	14.97	12.84	14.38	14.11	-0.035791983422204	4.62966513489418	0.747368768818794	0.93478954387307	16:69355560-69408571:-	TERF2	45;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000783,cellular_component nuclear telomere cap complex;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003720,molecular_function telomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006278,biological_process RNA-dependent DNA biosynthetic process;GO:0007049,biological_process cell cycle;GO:0008022,molecular_function protein C-terminus binding;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016233,biological_process telomere capping;GO:0016604,cellular_component nuclear body;GO:0019899,molecular_function enzyme binding;GO:0030870,cellular_component Mre11 complex;GO:0031627,biological_process telomeric loop formation;GO:0031848,biological_process protection from non-homologous end joining at telomere;GO:0032204,biological_process regulation of telomere maintenance;GO:0032205,biological_process negative regulation of telomere maintenance;GO:0032208,biological_process negative regulation of telomere maintenance via recombination;GO:0032210,biological_process regulation of telomere maintenance via telomerase;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0032214,biological_process negative regulation of telomere maintenance via semi-conservative replication;GO:0042162,molecular_function telomeric DNA binding;GO:0042803,molecular_function protein homodimerization activity;GO:0044877,molecular_function macromolecular complex binding;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0061820,biological_process telomeric D-loop disassembly;GO:0070187,cellular_component telosome;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0090398,biological_process cellular senescence;GO:0098505,molecular_function G-rich strand telomeric DNA binding;GO:1903770,biological_process negative regulation of beta-galactosidase activity;GO:1903824,biological_process negative regulation of telomere single strand break repair;GO:1904354,biological_process negative regulation of telomere capping;GO:1904357,biological_process negative regulation of telomere maintenance via telomere lengthening;GO:1904430,biological_process negative regulation of t-circle formation;GO:1905778,biological_process negative regulation of exonuclease activity;GO:1905839,biological_process negative regulation of telomeric D-loop disassembly;GO:2000773,biological_process negative regulation of cellular senescence	NA	telomeric repeat binding factor 2 [Source:HGNC Symbol%3BAcc:HGNC:11729]
ENSG00000099957	2.62	2.23	3.59	2.83	2.26	3.02	0.0797954146540108	1.99041200999496	0.747384422041313	0.93478954387307	22:21009807-21028830:+	P2RX6	25;GO:0001614,molecular_function purinergic nucleotide receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004931,molecular_function extracellular ATP-gated cation channel activity;GO:0005216,molecular_function ion channel activity;GO:0005524,molecular_function ATP binding;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006936,biological_process muscle contraction;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0015267,molecular_function channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0033198,biological_process response to ATP;GO:0035590,biological_process purinergic nucleotide receptor signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0051260,biological_process protein homooligomerization;GO:0060079,biological_process excitatory postsynaptic potential;GO:0098655,biological_process cation transmembrane transport;GO:0098794,cellular_component postsynapse	P2RX6, P2RXL1; P2X purinoceptor 6; K05221	purinergic receptor P2X 6 [Source:HGNC Symbol%3BAcc:HGNC:8538]
ENSG00000139160	2.07	2.80	3.46	2.76	3.57	2.68	-0.104053490111661	1.27505212072842	0.747424975665852	0.93478954387307	12:31647159-31673114:+	ETFBKMT	14;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0018023,biological_process peptidyl-lysine trimethylation;GO:0031072,molecular_function heat shock protein binding;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex;GO:1904733,biological_process negative regulation of electron carrier activity;GO:1904736,biological_process negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase	NA	electron transfer flavoprotein beta subunit lysine methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:28739]
ENSG00000154518	266.59	283.78	262.44	258.71	281.65	266.58	0.0209560877106619	6.84770513735172	0.747567437674062	0.93487352446586	2:175176257-175184607:-	ATP5G3	21;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005215,molecular_function transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008289,molecular_function lipid binding;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0033177,cellular_component proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism	ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c; K02128	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit C3 (subunit 9) [Source:HGNC Symbol%3BAcc:HGNC:843]
ENSG00000049540	1.17	1.51	1.31	1.58	1.14	1.08	0.0738102090749218	1.73752721913281	0.747899052022089	0.935153869253816	7:74027788-74069907:+	ELN	16;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005739,cellular_component mitochondrion;GO:0007519,biological_process skeletal muscle tissue development;GO:0007585,biological_process respiratory gaseous exchange;GO:0008015,biological_process blood circulation;GO:0008283,biological_process cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0022617,biological_process extracellular matrix disassembly;GO:0030198,biological_process extracellular matrix organization;GO:0030833,biological_process regulation of actin filament polymerization;GO:0043149,biological_process stress fiber assembly;GO:0050840,molecular_function extracellular matrix binding;GO:0071953,cellular_component elastic fiber	ELN; elastin; K14211	elastin [Source:HGNC Symbol%3BAcc:HGNC:3327]
ENSG00000267699	14.23	12.96	9.13	9.58	11.17	13.63	0.0837484971717536	1.67442090059194	0.748223754576118	0.935153869253816	18:50968018-51058144:+	AC091551.1	2;GO:0034414,biological_process tRNA 3'-trailer cleavage, endonucleolytic;GO:0042781,molecular_function 3'-tRNA processing endoribonuclease activity	rnz; ribonuclease Z [EC:3.1.26.11]; K00784	NA
ENSG00000064313	20.29	18.03	19.61	19.11	19.46	20.81	-0.021212886121142	6.23242237205226	0.74825480366118	0.935153869253816	8:119730774-119832863:-	TAF2	20;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0001075,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly;GO:0001129,molecular_function RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0014070,biological_process response to organic cyclic compound;GO:0033276,cellular_component transcription factor TFTC complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF2; transcription initiation factor TFIID subunit 2; K03128	TATA-box binding protein associated factor 2 [Source:HGNC Symbol%3BAcc:HGNC:11536]
ENSG00000125657	34.57	42.52	31.29	32.52	39.02	34.70	0.0335231215831764	4.77133367039278	0.748260768820937	0.935153869253816	19:6530998-6535928:+	TNFSF9	16;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032813,molecular_function tumor necrosis factor receptor superfamily binding;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0045585,biological_process positive regulation of cytotoxic T cell differentiation	TNFSF9, CD137L; tumor necrosis factor ligand superfamily member 9; K05472	TNF superfamily member 9 [Source:HGNC Symbol%3BAcc:HGNC:11939]
ENSG00000106366	140.61	69.18	144.03	166.51	69.18	143.14	-0.0868375960373889	7.20889825553026	0.748321925662031	0.935153869253816	7:101127088-101139266:+	SERPINE1	41;GO:0001300,biological_process chronological cell aging;GO:0001525,biological_process angiogenesis;GO:0002020,molecular_function protease binding;GO:0002576,biological_process platelet degranulation;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007623,biological_process circadian rhythm;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010469,biological_process regulation of receptor activity;GO:0010757,biological_process negative regulation of plasminogen activation;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0030194,biological_process positive regulation of blood coagulation;GO:0030195,biological_process negative regulation of blood coagulation;GO:0030198,biological_process extracellular matrix organization;GO:0030336,biological_process negative regulation of cell migration;GO:0030414,molecular_function peptidase inhibitor activity;GO:0031012,cellular_component extracellular matrix;GO:0031093,cellular_component platelet alpha granule lumen;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0033629,biological_process negative regulation of cell adhesion mediated by integrin;GO:0035491,biological_process positive regulation of leukotriene production involved in inflammatory response;GO:0042730,biological_process fibrinolysis;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048260,biological_process positive regulation of receptor-mediated endocytosis;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0051918,biological_process negative regulation of fibrinolysis;GO:0061044,biological_process negative regulation of vascular wound healing;GO:0061045,biological_process negative regulation of wound healing;GO:0070062,cellular_component extracellular exosome;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0090026,biological_process positive regulation of monocyte chemotaxis;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000098,biological_process negative regulation of smooth muscle cell-matrix adhesion;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	SERPINE1, PAI1; plasminogen activator inhibitor 1; K03982	serpin family E member 1 [Source:HGNC Symbol%3BAcc:HGNC:8583]
ENSG00000010310	1.11	1.44	1.86	1.38	0.99	1.78	0.0920296479680549	1.16463691207032	0.748366588394222	0.935153869253816	19:45668243-45683724:+	GIPR	25;GO:0002029,biological_process desensitization of G-protein coupled receptor protein signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007584,biological_process response to nutrient;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016519,molecular_function gastric inhibitory peptide receptor activity;GO:0017046,molecular_function peptide hormone binding;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031018,biological_process endocrine pancreas development;GO:0032024,biological_process positive regulation of insulin secretion;GO:0038192,biological_process gastric inhibitory peptide signaling pathway;GO:0048678,biological_process response to axon injury;GO:0050796,biological_process regulation of insulin secretion;GO:0051592,biological_process response to calcium ion;GO:0070542,biological_process response to fatty acid	GIPR; gastric inhibitory polypeptide receptor; K04580	gastric inhibitory polypeptide receptor [Source:HGNC Symbol%3BAcc:HGNC:4271]
ENSG00000109084	21.73	24.03	20.85	22.19	23.34	19.66	0.0377876837456534	3.56377162021708	0.748382349902979	0.935153869253816	17:28319094-28328685:+	TMEM97	12;GO:0001558,biological_process regulation of cell growth;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0042632,biological_process cholesterol homeostasis	NA	transmembrane protein 97 [Source:HGNC Symbol%3BAcc:HGNC:28106]
ENSG00000183878	4.94	5.47	5.69	5.69	5.28	4.92	0.0302824641884993	4.63809535587518	0.748394307352567	0.935153869253816	Y:13248378-13480673:-	UTY	11;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0010468,biological_process regulation of gene expression;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0032452,molecular_function histone demethylase activity;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0071557,biological_process histone H3-K27 demethylation;GO:0071558,molecular_function histone demethylase activity (H3-K27 specific)	UTX, KDM6A; lysine-specific demethylase 6A [EC:1.14.11.68]; K11447	ubiquitously transcribed tetratricopeptide repeat containing%2C Y-linked [Source:HGNC Symbol%3BAcc:HGNC:12638]
ENSG00000135951	3.37	3.19	3.37	2.93	3.91	3.56	-0.0503487069906956	2.86153898229958	0.749092835118278	0.935932497465847	2:98997260-99154964:-	TSGA10	11;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0030031,biological_process cell projection assembly;GO:0031514,cellular_component motile cilium;GO:0031965,cellular_component nuclear membrane;GO:0043005,cellular_component neuron projection	NA	testis specific 10 [Source:HGNC Symbol%3BAcc:HGNC:14927]
ENSG00000100897	31.28	35.38	31.91	31.58	33.77	32.30	0.0214422825591609	5.80576564443403	0.749213004653584	0.935945982250448	14:24114194-24125242:+	DCAF11	5;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 11 [Source:HGNC Symbol%3BAcc:HGNC:20258]
ENSG00000166938	12.95	11.52	11.68	12.27	11.80	11.81	0.0265075893711109	5.25419570681155	0.749276495476104	0.935945982250448	15:66293216-66333898:+	DIS3L	16;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006364,biological_process rRNA processing;GO:0016075,biological_process rRNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	DIS3 like exosome 3'-5' exoribonuclease [Source:HGNC Symbol%3BAcc:HGNC:28698]
ENSG00000106554	65.44	62.73	64.91	67.62	64.95	65.01	-0.0199379022446826	5.94056464841497	0.749329829340606	0.935945982250448	7:132784867-133082088:-	CHCHD3	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007007,biological_process inner mitochondrial membrane organization;GO:0008053,biological_process mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019902,molecular_function phosphatase binding;GO:0032947,molecular_function protein complex scaffold;GO:0042407,biological_process cristae formation;GO:0061617,cellular_component MICOS complex;GO:0070062,cellular_component extracellular exosome	NA	coiled-coil-helix-coiled-coil-helix domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:21906]
ENSG00000116266	34.20	32.88	29.47	31.83	34.04	33.06	-0.0240252983463215	5.85892492194731	0.7494136168601	0.935956456996119	1:108746673-108809526:+	STXBP3	27;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0007420,biological_process brain development;GO:0015031,biological_process protein transport;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017075,molecular_function syntaxin-1 binding;GO:0019905,molecular_function syntaxin binding;GO:0022615,biological_process protein to membrane docking;GO:0030073,biological_process insulin secretion;GO:0031091,cellular_component platelet alpha granule;GO:0032868,biological_process response to insulin;GO:0042581,cellular_component specific granule;GO:0043312,biological_process neutrophil degranulation;GO:0045955,biological_process negative regulation of calcium ion-dependent exocytosis;GO:0051291,biological_process protein heterooligomerization;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0070820,cellular_component tertiary granule	NA	syntaxin binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:11446]
ENSG00000254692	0.20	0.47	0.27	0.03	0.28	0.49	0.189173777836339	-0.236160220377057	0.749626418888712	0.936064501942414	14:24189156-24213473:-	AL136295.1	4;GO:0005622,cellular_component intracellular;GO:0007034,biological_process vacuolar transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	NA
ENSG00000180818	16.59	19.28	16.93	16.93	19.74	17.68	-0.0369062423632729	4.20459122570311	0.749690893160011	0.936064501942414	12:53985064-53990279:+	HOXC10	19;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009954,biological_process proximal/distal pattern formation;GO:0016604,cellular_component nuclear body;GO:0019907,cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0021520,biological_process spinal cord motor neuron cell fate specification;GO:0030326,biological_process embryonic limb morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050905,biological_process neuromuscular process	NA	homeobox C10 [Source:HGNC Symbol%3BAcc:HGNC:5122]
ENSG00000131591	6.84	6.24	7.51	7.09	5.96	8.47	-0.0480503474087172	3.28720848377454	0.749726357714612	0.936064501942414	1:1081817-1116361:-	C1orf159	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 1 open reading frame 159 [Source:HGNC Symbol%3BAcc:HGNC:26062]
ENSG00000010270	113.79	124.56	109.98	116.57	128.56	111.79	-0.0253170792723929	6.36892945499177	0.749837569487195	0.936099843619787	7:38178221-38230671:+	STARD3NL	14;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006700,biological_process C21-steroid hormone biosynthetic process;GO:0015485,molecular_function cholesterol binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044232,cellular_component organelle membrane contact site;GO:0099044,biological_process vesicle tethering to endoplasmic reticulum	NA	STARD3 N-terminal like [Source:HGNC Symbol%3BAcc:HGNC:19169]
ENSG00000134697	26.13	26.83	25.49	24.61	24.90	28.28	0.0219171461716504	5.96806440308712	0.749947111032371	0.936099843619787	1:37566815-37595935:-	GNL2	10;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042254,biological_process ribosome biogenesis	NUG2, GNL2; nuclear GTP-binding protein; K14537	G protein nucleolar 2 [Source:HGNC Symbol%3BAcc:HGNC:29925]
ENSG00000214960	0.94	1.91	1.47	1.83	1.74	1.09	-0.122710358446588	1.0999312740055	0.750029676071188	0.936099843619787	7:16087526-16421322:-	ISPD	11;GO:0003824,molecular_function catalytic activity;GO:0005829,cellular_component cytosol;GO:0006486,biological_process protein glycosylation;GO:0007411,biological_process axon guidance;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0035269,biological_process protein O-linked mannosylation;GO:0042803,molecular_function protein homodimerization activity;GO:0047349,molecular_function D-ribitol-5-phosphate cytidylyltransferase activity;GO:0070567,molecular_function cytidylyltransferase activity	NA	isoprenoid synthase domain containing [Source:HGNC Symbol%3BAcc:HGNC:37276]
ENSG00000174915	20.05	21.10	21.81	21.25	19.88	23.52	-0.028784652331618	5.02459994306232	0.750056315527464	0.936099843619787	11:448267-491399:+	PTDSS2	10;GO:0003882,molecular_function CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006659,biological_process phosphatidylserine biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity	PTDSS2; phosphatidylserine synthase 2 [EC:2.7.8.29]; K08730	phosphatidylserine synthase 2 [Source:HGNC Symbol%3BAcc:HGNC:15463]
ENSG00000177889	59.26	76.87	65.71	70.62	71.18	65.55	-0.0328068558561453	5.43645704803874	0.750398695491571	0.936254628836117	12:93405672-93442262:-	UBE2N	46;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0001650,cellular_component fibrillar center;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006282,biological_process regulation of DNA repair;GO:0006301,biological_process postreplication repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007254,biological_process JNK cascade;GO:0016567,biological_process protein ubiquitination;GO:0016574,biological_process histone ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031058,biological_process positive regulation of histone modification;GO:0031372,cellular_component UBC13-MMS2 complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033182,biological_process regulation of histone ubiquitination;GO:0035370,cellular_component UBC13-UEV1A complex;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0043234,cellular_component protein complex;GO:0045739,biological_process positive regulation of DNA repair;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070911,biological_process global genome nucleotide-excision repair	UBE2N, BLU, UBC13; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]; K10580	ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol%3BAcc:HGNC:12492]
ENSG00000126261	64.81	63.17	64.25	65.01	63.79	67.71	-0.0197702686836043	6.97964313983642	0.750430228131363	0.936254628836117	19:34428351-34471251:+	UBA2	21;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0008047,molecular_function enzyme activator activity;GO:0008134,molecular_function transcription factor binding;GO:0008641,molecular_function small protein activating enzyme activity;GO:0016874,molecular_function ligase activity;GO:0016881,molecular_function acid-amino acid ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019948,molecular_function SUMO activating enzyme activity;GO:0031510,cellular_component SUMO activating enzyme complex;GO:0032183,molecular_function SUMO binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0044388,molecular_function small protein activating enzyme binding;GO:0044390,molecular_function ubiquitin-like protein conjugating enzyme binding;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	UBLE1B, SAE2, UBA2; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]; K10685	ubiquitin like modifier activating enzyme 2 [Source:HGNC Symbol%3BAcc:HGNC:30661]
ENSG00000152284	0.80	1.03	0.96	1.19	0.86	0.96	-0.108132904156312	0.887424289915002	0.75045997324721	0.936254628836117	2:85133409-85310388:+	TCF7L1	17;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005829,cellular_component cytosol;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008013,molecular_function beta-catenin binding;GO:0016055,biological_process Wnt signaling pathway;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0060070,biological_process canonical Wnt signaling pathway;GO:1904837,biological_process beta-catenin-TCF complex assembly	TCF7L1; transcription factor 7-like 1; K04490	transcription factor 7 like 1 [Source:HGNC Symbol%3BAcc:HGNC:11640]
ENSG00000165861	12.10	12.51	13.05	12.67	13.19	11.40	0.0283532727220572	4.89773665830665	0.750530877690308	0.936254628836117	14:72969450-73027212:-	ZFYVE1	19;GO:0000407,cellular_component pre-autophagosomal structure;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0008270,molecular_function zinc ion binding;GO:0009267,biological_process cellular response to starvation;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0097629,cellular_component extrinsic component of omegasome membrane;GO:1990462,cellular_component omegasome	NA	zinc finger FYVE-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:13180]
ENSG00000167880	2.51	2.46	3.26	2.83	2.85	2.86	-0.0369497571122792	4.12475020248797	0.750557464879417	0.936254628836117	17:76004501-76027452:-	EVPL	17;GO:0001533,cellular_component cornified envelope;GO:0005198,molecular_function structural molecule activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008544,biological_process epidermis development;GO:0018149,biological_process peptide cross-linking;GO:0019215,molecular_function intermediate filament binding;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0030216,biological_process keratinocyte differentiation;GO:0030674,molecular_function protein binding, bridging;GO:0031424,biological_process keratinization;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification	NA	envoplakin [Source:HGNC Symbol%3BAcc:HGNC:3503]
ENSG00000104517	28.62	26.95	28.95	26.63	27.58	29.80	0.0209467900732017	7.8840142052477	0.750778973672947	0.936373686357431	8:102253011-102412841:-	UBR5	27;GO:0000209,biological_process protein polyubiquitination;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0043130,molecular_function ubiquitin binding;GO:0043234,cellular_component protein complex;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050847,biological_process progesterone receptor signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901315,biological_process negative regulation of histone H2A K63-linked ubiquitination;GO:2000780,biological_process negative regulation of double-strand break repair	EDD1, UBR5; E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]; K10593	ubiquitin protein ligase E3 component n-recognin 5 [Source:HGNC Symbol%3BAcc:HGNC:16806]
ENSG00000101350	17.46	18.51	16.72	16.30	19.66	18.11	-0.028403288178781	5.32244526774959	0.750803778322365	0.936373686357431	20:32277663-32335011:+	KIF3B	37;GO:0000166,molecular_function nucleotide binding;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005873,cellular_component plus-end kinesin complex;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005929,cellular_component cilium;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007052,biological_process mitotic spindle organization;GO:0007100,biological_process mitotic centrosome separation;GO:0007368,biological_process determination of left/right symmetry;GO:0008017,molecular_function microtubule binding;GO:0008089,biological_process anterograde axonal transport;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016939,cellular_component kinesin II complex;GO:0017048,molecular_function Rho GTPase binding;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030424,cellular_component axon;GO:0030496,cellular_component midbody;GO:0030990,cellular_component intraciliary transport particle;GO:0032467,biological_process positive regulation of cytokinesis;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0070062,cellular_component extracellular exosome;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule;GO:0090307,biological_process mitotic spindle assembly;GO:0097542,cellular_component ciliary tip;GO:1904115,cellular_component axon cytoplasm	KIF3A; kinesin family member 3A; K10394	kinesin family member 3B [Source:HGNC Symbol%3BAcc:HGNC:6320]
ENSG00000112531	117.63	99.03	123.09	114.61	107.50	114.68	0.0264219822437194	7.03140512429568	0.750935651221526	0.936377108121128	6:163413999-163578596:+	QKI	22;GO:0001570,biological_process vasculogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0007275,biological_process multicellular organism development;GO:0007286,biological_process spermatid development;GO:0008366,biological_process axon ensheathment;GO:0008380,biological_process RNA splicing;GO:0010628,biological_process positive regulation of gene expression;GO:0017124,molecular_function SH3 domain binding;GO:0030154,biological_process cell differentiation;GO:0042552,biological_process myelination;GO:0042692,biological_process muscle cell differentiation;GO:0042759,biological_process long-chain fatty acid biosynthetic process;GO:0051028,biological_process mRNA transport;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization	NA	QKI%2C KH domain containing RNA binding [Source:HGNC Symbol%3BAcc:HGNC:21100]
ENSG00000023516	5.42	5.31	5.91	5.72	5.63	5.14	0.0286856567083905	4.98549072470656	0.751056129707944	0.936377108121128	13:42272152-42323267:+	AKAP11	11;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0035556,biological_process intracellular signal transduction;GO:0051018,molecular_function protein kinase A binding	NA	A-kinase anchoring protein 11 [Source:HGNC Symbol%3BAcc:HGNC:369]
ENSG00000170921	10.84	10.13	10.92	10.97	10.74	10.93	-0.0196286910583756	6.09832843135763	0.751065160286597	0.936377108121128	17:63009555-63427699:+	TANC2	1;GO:0001701,biological_process in utero embryonic development	NA	tetratricopeptide repeat%2C ankyrin repeat and coiled-coil containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30212]
ENSG00000185338	4.24	3.17	4.07	4.38	3.35	4.67	-0.0845278033912703	1.43068268219379	0.751108262753731	0.936377108121128	16:11254404-11256179:-	SOCS1	30;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001932,biological_process regulation of protein phosphorylation;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007259,biological_process JAK-STAT cascade;GO:0009968,biological_process negative regulation of signal transduction;GO:0010533,biological_process regulation of activation of Janus kinase activity;GO:0016567,biological_process protein ubiquitination;GO:0019210,molecular_function kinase inhibitor activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019901,molecular_function protein kinase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0042509,biological_process regulation of tyrosine phosphorylation of STAT protein;GO:0042532,biological_process negative regulation of tyrosine phosphorylation of STAT protein;GO:0045444,biological_process fat cell differentiation;GO:0045591,biological_process positive regulation of regulatory T cell differentiation;GO:0046425,biological_process regulation of JAK-STAT cascade;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0050707,biological_process regulation of cytokine secretion;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway;GO:0071230,biological_process cellular response to amino acid stimulus	SOCS1, JAB; suppressor of cytokine signaling 1; K04694	suppressor of cytokine signaling 1 [Source:HGNC Symbol%3BAcc:HGNC:19383]
ENSG00000137776	32.55	34.58	33.32	33.06	33.24	36.45	-0.0222622454533298	6.73384292851923	0.751190290777392	0.93638532631249	15:58879044-58933653:-	SLTM	12;GO:0003676,molecular_function nucleic acid binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0016604,cellular_component nuclear body;GO:0043565,molecular_function sequence-specific DNA binding;GO:0050684,biological_process regulation of mRNA processing	NA	SAFB like transcription modulator [Source:HGNC Symbol%3BAcc:HGNC:20709]
ENSG00000179134	29.56	31.03	32.33	32.50	29.47	30.26	0.0222155200835542	6.04314022076073	0.751353486647073	0.936451299118048	19:39342395-39385710:+	SAMD4B	12;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0017148,biological_process negative regulation of translation;GO:0030371,molecular_function translation repressor activity;GO:0043488,biological_process regulation of mRNA stability	NA	sterile alpha motif domain containing 4B [Source:HGNC Symbol%3BAcc:HGNC:25492]
ENSG00000162627	65.74	64.36	65.34	65.29	63.70	65.36	0.0202637702414803	6.57192508283143	0.751394098059756	0.936451299118048	1:98661700-98760500:+	SNX7	12;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0019898,cellular_component extrinsic component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035091,molecular_function phosphatidylinositol binding	NA	sorting nexin 7 [Source:HGNC Symbol%3BAcc:HGNC:14971]
ENSG00000254004	12.11	9.36	8.93	10.78	10.80	10.07	-0.0388926118069901	3.69814047114343	0.751478490666972	0.936453451925845	19:36510694-36528660:-	ZNF260	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 260 [Source:HGNC Symbol%3BAcc:HGNC:13499]
ENSG00000142606	0.48	0.40	0.96	0.63	0.58	0.51	0.144735773383308	0.650887890289157	0.751577223834298	0.936453451925845	1:2590638-2632990:-	MMEL1	9;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	membrane metalloendopeptidase like 1 [Source:HGNC Symbol%3BAcc:HGNC:14668]
ENSG00000181523	3.83	3.61	3.85	3.65	2.82	4.45	0.0586548731722079	2.64442095314919	0.751647495831379	0.936453451925845	17:80206715-80220923:-	SGSH	11;GO:0003824,molecular_function catalytic activity;GO:0005764,cellular_component lysosome;GO:0006027,biological_process glycosaminoglycan catabolic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016250,molecular_function N-sulfoglucosamine sulfohydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0030200,biological_process heparan sulfate proteoglycan catabolic process;GO:0043202,cellular_component lysosomal lumen;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	SGSH; N-sulfoglucosamine sulfohydrolase [EC:3.10.1.1]; K01565	N-sulfoglucosamine sulfohydrolase [Source:HGNC Symbol%3BAcc:HGNC:10818]
ENSG00000166068	14.48	15.21	15.91	15.18	12.70	19.48	-0.0449185869530025	4.3806433096144	0.751697590831315	0.936453451925845	15:38252325-38357249:+	SPRED1	22;GO:0000165,biological_process MAPK cascade;GO:0000188,biological_process inactivation of MAPK activity;GO:0005173,molecular_function stem cell factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0007275,biological_process multicellular organism development;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0009966,biological_process regulation of signal transduction;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0060979,biological_process vasculogenesis involved in coronary vascular morphogenesis;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:0090311,biological_process regulation of protein deacetylation	NA	sprouty related EVH1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20249]
ENSG00000116898	71.45	65.57	67.78	68.07	68.66	66.85	0.0230941148924172	5.7194437497203	0.752127592805589	0.936677302849139	1:36455717-36464437:-	MRPS15	15;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15; K02956	mitochondrial ribosomal protein S15 [Source:HGNC Symbol%3BAcc:HGNC:14504]
ENSG00000163683	91.17	86.82	94.05	88.82	86.25	94.45	0.0272993196102289	4.79779239161329	0.752267192884023	0.936677302849139	4:39546329-39639090:-	SMIM14	5;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 14 [Source:HGNC Symbol%3BAcc:HGNC:27321]
ENSG00000151623	0.52	0.55	0.65	0.63	0.56	0.66	-0.100895498138442	0.944885857962482	0.752323223338812	0.936677302849139	4:148078761-148444698:-	NR3C2	22;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0005496,molecular_function steroid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0043235,cellular_component receptor complex;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NR3C2, MR; mineralocorticoid receptor; K08555	nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol%3BAcc:HGNC:7979]
ENSG00000144647	7.59	7.58	7.91	7.01	8.63	7.03	0.0397649227705818	3.74639526076896	0.752359076440153	0.936677302849139	3:43079231-43106076:-	POMGNT2	13;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0035269,biological_process protein O-linked mannosylation;GO:0097363,molecular_function protein O-GlcNAc transferase activity	NA	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1%2C4-) [Source:HGNC Symbol%3BAcc:HGNC:25902]
ENSG00000128185	43.77	47.49	39.92	43.79	42.75	42.94	0.0248956321963197	4.84731285043453	0.752377183831726	0.936677302849139	22:20314275-20320080:-	DGCR6L	2;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	DiGeorge syndrome critical region gene 6 like [Source:HGNC Symbol%3BAcc:HGNC:18551]
ENSG00000105722	24.70	21.16	22.47	21.63	25.33	23.35	-0.02493717074556	5.25620547124192	0.752434576919442	0.936677302849139	19:42247571-42255157:-	ERF	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding	NA	ETS2 repressor factor [Source:HGNC Symbol%3BAcc:HGNC:3444]
ENSG00000196411	9.28	9.26	8.18	8.82	10.32	8.38	-0.0320842758508886	4.75015871038994	0.752456211480038	0.936677302849139	7:100802564-100827521:-	EPHB4	27;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0003007,biological_process heart morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005003,molecular_function ephrin receptor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0046777,biological_process protein autophosphorylation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0070062,cellular_component extracellular exosome	EPHB4, HTK; Eph receptor B4 [EC:2.7.10.1]; K05113	EPH receptor B4 [Source:HGNC Symbol%3BAcc:HGNC:3395]
ENSG00000109458	5.71	6.19	6.65	5.76	6.26	7.15	-0.0387576382688471	3.87152073319459	0.752517311460734	0.936677302849139	4:143336761-143474568:+	GAB1	17;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0008283,biological_process cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009967,biological_process positive regulation of signal transduction;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0035728,biological_process response to hepatocyte growth factor;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling	GAB1; GRB2-associated-binding protein 1; K09593	GRB2 associated binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:4066]
ENSG00000111843	331.27	343.30	297.03	328.90	329.10	305.55	0.0224781414964114	6.76193335755192	0.75262921579317	0.936677302849139	6:10722914-10731129:+	TMEM14C	6;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006783,biological_process heme biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane	NA	transmembrane protein 14C [Source:HGNC Symbol%3BAcc:HGNC:20952]
ENSG00000173933	21.20	21.45	20.65	20.58	22.02	22.29	-0.0260336616378832	4.93690666797791	0.752860236401118	0.936677302849139	11:66638616-66666682:+	RBM4	34;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0002190,biological_process cap-independent translational initiation;GO:0002192,biological_process IRES-dependent translational initiation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016607,cellular_component nuclear speck;GO:0017148,biological_process negative regulation of translation;GO:0030154,biological_process cell differentiation;GO:0031047,biological_process gene silencing by RNA;GO:0032055,biological_process negative regulation of translation in response to stress;GO:0035198,molecular_function miRNA binding;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0045947,biological_process negative regulation of translational initiation;GO:0046685,biological_process response to arsenic-containing substance;GO:0046822,biological_process regulation of nucleocytoplasmic transport;GO:0046872,molecular_function metal ion binding;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0097157,molecular_function pre-mRNA intronic binding;GO:0097158,molecular_function pre-mRNA intronic pyrimidine-rich binding;GO:0097167,biological_process circadian regulation of translation	NA	RNA binding motif protein 4 [Source:HGNC Symbol%3BAcc:HGNC:9901]
ENSG00000146700	0.74	0.55	0.51	0.69	0.48	0.49	0.137577815236044	0.204908753259836	0.752917532722815	0.936677302849139	7:76389333-76409695:-	SSC4D	5;GO:0005044,molecular_function scavenger receptor activity;GO:0005576,cellular_component extracellular region;GO:0006898,biological_process receptor-mediated endocytosis;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	NA	scavenger receptor cysteine rich family member with 4 domains [Source:HGNC Symbol%3BAcc:HGNC:14461]
ENSG00000198689	7.24	7.60	7.31	6.90	8.62	7.36	-0.0368501235648689	4.07433885877546	0.752918701134924	0.936677302849139	X:135973840-136047269:+	SLC9A6	40;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0006885,biological_process regulation of pH;GO:0010008,cellular_component endosome membrane;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015386,molecular_function potassium:proton antiporter activity;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031547,biological_process brain-derived neurotrophic factor receptor signaling pathway;GO:0031901,cellular_component early endosome membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043679,cellular_component axon terminus;GO:0044308,cellular_component axonal spine;GO:0045202,cellular_component synapse;GO:0048675,biological_process axon extension;GO:0048812,biological_process neuron projection morphogenesis;GO:0050808,biological_process synapse organization;GO:0051386,biological_process regulation of neurotrophin TRK receptor signaling pathway;GO:0051453,biological_process regulation of intracellular pH;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0055085,biological_process transmembrane transport;GO:0060996,biological_process dendritic spine development;GO:0071805,biological_process potassium ion transmembrane transport;GO:0097484,biological_process dendrite extension;GO:0098719,biological_process sodium ion import across plasma membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	solute carrier family 9 member A6 [Source:HGNC Symbol%3BAcc:HGNC:11079]
ENSG00000158169	8.73	8.24	8.49	8.92	9.58	7.84	-0.0329639218190521	3.98962809902396	0.752924639577871	0.936677302849139	9:95099053-95426796:-	FANCC	18;GO:0002262,biological_process myeloid cell homeostasis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006461,biological_process protein complex assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007276,biological_process gamete generation;GO:0007281,biological_process germ cell development;GO:0019430,biological_process removal of superoxide radicals;GO:0034599,biological_process cellular response to oxidative stress;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0048854,biological_process brain morphogenesis;GO:0097150,biological_process neuronal stem cell population maintenance	FANCC; fanconi anemia group C protein; K10890	Fanconi anemia complementation group C [Source:HGNC Symbol%3BAcc:HGNC:3584]
ENSG00000080189	39.67	43.01	43.59	39.65	43.50	42.06	0.0222600909062016	5.63516407364184	0.752933708839822	0.936677302849139	20:46345979-46364458:-	SLC35C2	13;GO:0005654,cellular_component nucleoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006810,biological_process transport;GO:0010629,biological_process negative regulation of gene expression;GO:0015786,biological_process UDP-glucose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0036065,biological_process fucosylation;GO:0036066,biological_process protein O-linked fucosylation;GO:0045747,biological_process positive regulation of Notch signaling pathway	NA	solute carrier family 35 member C2 [Source:HGNC Symbol%3BAcc:HGNC:17117]
ENSG00000165661	15.28	16.52	14.55	13.91	16.99	14.84	0.0277524152873253	5.0114515652431	0.75309518791204	0.936784303793181	9:136206332-136245841:-	QSOX2	16;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016971,molecular_function flavin-linked sulfhydryl oxidase activity;GO:0016972,molecular_function thiol oxidase activity;GO:0030173,cellular_component integral component of Golgi membrane;GO:0031965,cellular_component nuclear membrane;GO:0045454,biological_process cell redox homeostasis;GO:0055114,biological_process oxidation-reduction process	NA	quiescin sulfhydryl oxidase 2 [Source:HGNC Symbol%3BAcc:HGNC:30249]
ENSG00000170633	13.80	14.28	13.27	14.82	13.96	12.02	0.0304804987613208	4.44936957618465	0.753328544042021	0.936980683085532	12:121400040-121430623:+	RNF34	28;GO:0002039,molecular_function p53 binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035872,biological_process nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070417,biological_process cellular response to cold;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1901797,biological_process negative regulation of signal transduction by p53 class mediator;GO:1901981,molecular_function phosphatidylinositol phosphate binding;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000374,biological_process regulation of oxygen metabolic process;GO:2001271,biological_process negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	NA	ring finger protein 34 [Source:HGNC Symbol%3BAcc:HGNC:17297]
ENSG00000161542	45.06	35.71	40.82	44.09	37.64	38.59	0.0315674969768758	5.60322602964921	0.753509515525459	0.937111874182699	17:76309485-76384521:-	PRPSAP1	9;GO:0000287,molecular_function magnesium ion binding;GO:0004749,molecular_function ribose phosphate diphosphokinase activity;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0009116,biological_process nucleoside metabolic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0043086,biological_process negative regulation of catalytic activity	NA	phosphoribosyl pyrophosphate synthetase associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:9466]
ENSG00000115363	30.77	24.41	27.25	31.13	20.58	28.68	0.0525101995576881	3.79895149302388	0.753755478290997	0.93732385814728	2:75469301-75569722:-	EVA1A	13;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process	NA	eva-1 homolog A%2C regulator of programmed cell death [Source:HGNC Symbol%3BAcc:HGNC:25816]
ENSG00000169105	13.21	10.93	13.90	11.42	14.12	14.03	-0.0363956285257776	3.88872591399118	0.753883874182618	0.937363885294748	15:40470997-40474571:+	CHST14	13;GO:0000139,cellular_component Golgi membrane;GO:0001537,molecular_function N-acetylgalactosamine 4-O-sulfotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016051,biological_process carbohydrate biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0042301,molecular_function phosphate ion binding;GO:0050655,biological_process dermatan sulfate proteoglycan metabolic process;GO:0070062,cellular_component extracellular exosome	D4ST1; dermatan 4-sulfotransferase 1 [EC:2.8.2.35]; K08105	carbohydrate sulfotransferase 14 [Source:HGNC Symbol%3BAcc:HGNC:24464]
ENSG00000185567	29.43	27.33	30.14	29.91	29.07	29.81	-0.0189601189739932	8.99320737466107	0.753938695785287	0.937363885294748	14:104937243-104978357:-	AHNAK2	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0030018,cellular_component Z disc;GO:0030315,cellular_component T-tubule;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere	NA	AHNAK nucleoprotein 2 [Source:HGNC Symbol%3BAcc:HGNC:20125]
ENSG00000177479	39.32	38.04	39.33	42.27	36.26	41.04	-0.0228105436744579	5.91330334405832	0.75421845581404	0.937436403990797	3:48918820-48986382:+	ARIH2	22;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031466,cellular_component Cul5-RING ubiquitin ligase complex;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0048588,biological_process developmental cell growth;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	ariadne RBR E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:690]
ENSG00000140553	25.25	28.24	26.18	26.25	27.65	25.14	0.0213708985481416	6.45133763798639	0.754328447102989	0.937436403990797	15:90930179-90954093:+	UNC45A	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0016607,cellular_component nuclear speck;GO:0030154,biological_process cell differentiation;GO:0045296,molecular_function cadherin binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051879,molecular_function Hsp90 protein binding;GO:0061077,biological_process chaperone-mediated protein folding	NA	unc-45 myosin chaperone A [Source:HGNC Symbol%3BAcc:HGNC:30594]
ENSG00000157353	4.76	4.75	4.70	4.36	4.93	4.71	0.0317828882577782	4.01270800219032	0.754394721860404	0.937436403990797	16:70454420-70480274:+	FUK	10;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0042352,biological_process GDP-L-fucose salvage;GO:0046835,biological_process carbohydrate phosphorylation;GO:0050201,molecular_function fucokinase activity	FUK; fucokinase [EC:2.7.1.52]; K05305	fucokinase [Source:HGNC Symbol%3BAcc:HGNC:29500]
ENSG00000177427	5.90	7.75	6.33	5.93	7.63	7.16	-0.0531484376568872	3.48942436317324	0.754417821081548	0.937436403990797	17:18260533-18266552:+	MIEF2	9;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0007005,biological_process mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032464,biological_process positive regulation of protein homooligomerization;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090314,biological_process positive regulation of protein targeting to membrane	NA	mitochondrial elongation factor 2 [Source:HGNC Symbol%3BAcc:HGNC:17920]
ENSG00000009780	5.24	6.34	5.84	5.49	5.96	5.46	0.0455222221858683	2.74047293353072	0.754438942051218	0.937436403990797	1:27725978-27763122:+	FAM76A	1;GO:0005654,cellular_component nucleoplasm	NA	family with sequence similarity 76 member A [Source:HGNC Symbol%3BAcc:HGNC:28530]
ENSG00000126746	24.21	22.56	24.22	24.44	23.34	24.99	-0.0213803020610516	5.45859996544909	0.754504478336436	0.937436403990797	12:6666476-6689572:-	ZNF384	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 384 [Source:HGNC Symbol%3BAcc:HGNC:11955]
ENSG00000080802	14.91	15.42	14.65	13.68	15.95	14.90	0.0244372964366046	5.16320018502292	0.754525667628458	0.937436403990797	7:135361794-135510127:-	CNOT4	15;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030014,cellular_component CCR4-NOT complex;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination	CNOT4, NOT4, MOT2; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]; K10643	CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:7880]
ENSG00000147050	6.51	7.06	7.71	6.96	6.88	7.23	0.026266135009539	4.9859758067766	0.754919139243409	0.93783139265697	X:44873176-45112602:+	KDM6A	31;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0001843,biological_process neural tube closure;GO:0003007,biological_process heart morphogenesis;GO:0003016,biological_process respiratory system process;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007507,biological_process heart development;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0021915,biological_process neural tube development;GO:0031490,molecular_function chromatin DNA binding;GO:0032452,molecular_function histone demethylase activity;GO:0032525,biological_process somite rostral/caudal axis specification;GO:0035097,cellular_component histone methyltransferase complex;GO:0035264,biological_process multicellular organism growth;GO:0042802,molecular_function identical protein binding;GO:0044666,cellular_component MLL3/4 complex;GO:0046872,molecular_function metal ion binding;GO:0048333,biological_process mesodermal cell differentiation;GO:0048568,biological_process embryonic organ development;GO:0048570,biological_process notochord morphogenesis;GO:0051213,molecular_function dioxygenase activity;GO:0051568,biological_process histone H3-K4 methylation;GO:0055114,biological_process oxidation-reduction process;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0071557,biological_process histone H3-K27 demethylation;GO:0071558,molecular_function histone demethylase activity (H3-K27 specific);GO:0072358,biological_process cardiovascular system development	UTX, KDM6A; lysine-specific demethylase 6A [EC:1.14.11.68]; K11447	lysine demethylase 6A [Source:HGNC Symbol%3BAcc:HGNC:12637]
ENSG00000135678	4.88	4.40	3.76	4.26	4.86	4.51	-0.0495445327930221	2.66280522953474	0.755310672309002	0.938223894263148	12:68842196-68971570:-	CPM	21;GO:0004180,molecular_function carboxypeptidase activity;GO:0004181,molecular_function metallocarboxypeptidase activity;GO:0004185,molecular_function serine-type carboxypeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0006508,biological_process proteolysis;GO:0006518,biological_process peptide metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0031225,cellular_component anchored component of membrane;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	carboxypeptidase M [Source:HGNC Symbol%3BAcc:HGNC:2311]
ENSG00000116095	17.23	19.81	20.02	19.67	19.78	19.26	-0.0334055185547877	4.37204942932086	0.755446548587705	0.938241166429393	2:178480467-178516462:+	PLEKHA3	7;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008150,biological_process biological_process;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding	NA	pleckstrin homology domain containing A3 [Source:HGNC Symbol%3BAcc:HGNC:14338]
ENSG00000122965	8.63	7.71	7.57	7.60	8.61	8.42	-0.028320855649884	4.55829992192596	0.755601740997407	0.938241166429393	12:113816737-113966371:-	RBM19	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0040019,biological_process positive regulation of embryonic development	NA	RNA binding motif protein 19 [Source:HGNC Symbol%3BAcc:HGNC:29098]
ENSG00000155545	4.47	3.85	4.02	4.44	4.28	3.36	0.053239322018862	2.85456761612417	0.755705756857288	0.938241166429393	5:56919601-56971675:-	MIER3	6;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043234,cellular_component protein complex	NA	MIER family member 3 [Source:HGNC Symbol%3BAcc:HGNC:26678]
ENSG00000206560	34.09	29.75	32.23	32.77	31.90	33.72	-0.020530807848724	6.68871441668492	0.755855851806106	0.938241166429393	3:15667235-15859771:-	ANKRD28	6;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0048208,biological_process COPII vesicle coating	NA	ankyrin repeat domain 28 [Source:HGNC Symbol%3BAcc:HGNC:29024]
ENSG00000058600	12.10	12.13	12.32	13.32	11.46	12.75	-0.0272173690321083	4.82215562134457	0.755856600564398	0.938241166429393	16:22297374-22335103:+	POLR3E	12;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0032481,biological_process positive regulation of type I interferon production;GO:0045087,biological_process innate immune response;GO:0051607,biological_process defense response to virus	RPC5, POLR3E; DNA-directed RNA polymerase III subunit RPC5; K14721	RNA polymerase III subunit E [Source:HGNC Symbol%3BAcc:HGNC:30347]
ENSG00000123130	37.33	36.01	32.21	38.26	34.75	35.21	-0.0248982773743287	5.6079938573788	0.755861533308752	0.938241166429393	X:23702252-23766475:-	ACOT9	7;GO:0003986,molecular_function acetyl-CoA hydrolase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006637,biological_process acyl-CoA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0047617,molecular_function acyl-CoA hydrolase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity	NA	acyl-CoA thioesterase 9 [Source:HGNC Symbol%3BAcc:HGNC:17152]
ENSG00000171608	6.87	6.15	7.07	6.99	6.25	7.48	-0.0287336970867038	4.50708913739435	0.755988193262227	0.938241166429393	1:9651731-9729114:+	PIK3CD	53;GO:0000166,molecular_function nucleotide binding;GO:0001779,biological_process natural killer cell differentiation;GO:0001816,biological_process cytokine production;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002551,biological_process mast cell chemotaxis;GO:0002679,biological_process respiratory burst involved in defense response;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005942,cellular_component phosphatidylinositol 3-kinase complex;GO:0006468,biological_process protein phosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007411,biological_process axon guidance;GO:0010628,biological_process positive regulation of gene expression;GO:0010818,biological_process T cell chemotaxis;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030101,biological_process natural killer cell activation;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0030217,biological_process T cell differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030593,biological_process neutrophil chemotaxis;GO:0033031,biological_process positive regulation of neutrophil apoptotic process;GO:0035004,molecular_function phosphatidylinositol 3-kinase activity;GO:0035005,molecular_function 1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0035747,biological_process natural killer cell chemotaxis;GO:0035754,biological_process B cell chemotaxis;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042110,biological_process T cell activation;GO:0042113,biological_process B cell activation;GO:0042629,cellular_component mast cell granule;GO:0043303,biological_process mast cell degranulation;GO:0045087,biological_process innate immune response;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050853,biological_process B cell receptor signaling pathway;GO:0060374,biological_process mast cell differentiation;GO:0072672,biological_process neutrophil extravasation	PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]; K00922	phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol%3BAcc:HGNC:8977]
ENSG00000146909	11.39	10.26	9.84	9.87	10.91	11.64	-0.0286656877815794	4.79063088630646	0.756029754181361	0.938241166429393	7:156949722-156973182:+	NOM1	8;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008150,biological_process biological_process;GO:0022008,biological_process neurogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0048820,biological_process hair follicle maturation	NA	nucleolar protein with MIF4G domain 1 [Source:HGNC Symbol%3BAcc:HGNC:13244]
ENSG00000143748	11.24	9.21	11.45	11.25	10.83	10.82	-0.0246006747922872	4.94156498654788	0.756050246246356	0.938241166429393	1:224227333-224330387:-	NVL	12;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0016020,cellular_component membrane;GO:0042254,biological_process ribosome biogenesis;GO:0051973,biological_process positive regulation of telomerase activity;GO:1990275,molecular_function preribosome binding	RIX7, NVL; ribosome biogenesis ATPase; K14571	nuclear VCP-like [Source:HGNC Symbol%3BAcc:HGNC:8070]
ENSG00000172466	19.95	21.17	23.17	21.09	24.28	20.87	-0.0303152656033381	4.60998798982104	0.756080430821978	0.938241166429393	18:35332211-35345482:-	ZNF24	15;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008270,molecular_function zinc ion binding;GO:0042552,biological_process myelination;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 24 [Source:HGNC Symbol%3BAcc:HGNC:13032]
ENSG00000186918	73.15	73.65	81.73	79.35	73.08	81.60	-0.0221322859222664	6.89374935228808	0.756233691153169	0.938275463605225	8:28345584-28402701:-	ZNF395	11;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001158,molecular_function enhancer sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 395 [Source:HGNC Symbol%3BAcc:HGNC:18737]
ENSG00000053524	2.77	2.15	2.33	2.58	2.13	2.88	-0.0474702251605108	3.17414327647313	0.75625924541773	0.938275463605225	3:183178042-183428778:-	MCF2L2	4;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	MCF.2 cell line derived transforming sequence-like 2 [Source:HGNC Symbol%3BAcc:HGNC:30319]
ENSG00000105819	60.28	55.76	53.35	57.31	58.30	57.72	-0.0207516392629808	6.6896649292448	0.756553355239399	0.938469876083733	7:103297421-103329511:+	PMPCB	16;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0005759,cellular_component mitochondrial matrix;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0006508,biological_process proteolysis;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009060,biological_process aerobic respiration;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	peptidase%2C mitochondrial processing beta subunit [Source:HGNC Symbol%3BAcc:HGNC:9119]
ENSG00000065057	14.18	13.96	13.06	14.66	11.92	16.12	-0.0428305766067154	3.80338596335616	0.756674712664903	0.938469876083733	16:2039814-2047866:-	NTHL1	25;GO:0000703,molecular_function oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003824,molecular_function catalytic activity;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006285,biological_process base-excision repair, AP site formation;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008152,biological_process metabolic process;GO:0008534,molecular_function oxidized purine nucleobase lesion DNA N-glycosylase activity;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016829,molecular_function lyase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0045008,biological_process depyrimidination;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding	NTH; endonuclease III [EC:4.2.99.18]; K10773	nth like DNA glycosylase 1 [Source:HGNC Symbol%3BAcc:HGNC:8028]
ENSG00000126267	288.80	329.29	274.72	295.13	318.66	269.28	0.0251050808461267	6.25650100382566	0.756738076873108	0.938469876083733	19:35648222-35658861:+	COX6B1	7;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0021762,biological_process substantia nigra development;GO:1902600,biological_process hydrogen ion transmembrane transport	COX6B; cytochrome c oxidase subunit 6b; K02267	cytochrome c oxidase subunit 6B1 [Source:HGNC Symbol%3BAcc:HGNC:2280]
ENSG00000104164	18.51	18.91	18.89	19.12	22.31	16.92	-0.0379203678477333	3.85190941876559	0.7568054615686	0.938469876083733	15:45587122-45615999:+	BLOC1S6	29;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0007596,biological_process blood coagulation;GO:0008089,biological_process anterograde axonal transport;GO:0016020,cellular_component membrane;GO:0016081,biological_process synaptic vesicle docking;GO:0019898,cellular_component extrinsic component of membrane;GO:0019905,molecular_function syntaxin binding;GO:0030133,cellular_component transport vesicle;GO:0030318,biological_process melanocyte differentiation;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0031201,cellular_component SNARE complex;GO:0032402,biological_process melanosome transport;GO:0032438,biological_process melanosome organization;GO:0032816,biological_process positive regulation of natural killer cell activation;GO:0033299,biological_process secretion of lysosomal enzymes;GO:0035646,biological_process endosome to melanosome transport;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043473,biological_process pigmentation;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0050942,biological_process positive regulation of pigment cell differentiation;GO:0051015,molecular_function actin filament binding;GO:0061025,biological_process membrane fusion;GO:0098793,cellular_component presynapse;GO:1904115,cellular_component axon cytoplasm	NA	biogenesis of lysosomal organelles complex 1 subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:8549]
ENSG00000136250	4.49	4.06	3.55	4.04	4.67	3.90	-0.0453187707248622	3.13401079682599	0.756828620289236	0.938469876083733	7:36512948-36724549:-	AOAH	10;GO:0003824,molecular_function catalytic activity;GO:0004465,molecular_function lipoprotein lipase activity;GO:0005576,cellular_component extracellular region;GO:0006629,biological_process lipid metabolic process;GO:0006954,biological_process inflammatory response;GO:0008653,biological_process lipopolysaccharide metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0050528,molecular_function acyloxyacyl hydrolase activity;GO:0050728,biological_process negative regulation of inflammatory response	NA	acyloxyacyl hydrolase [Source:HGNC Symbol%3BAcc:HGNC:548]
ENSG00000187720	6.29	6.34	5.80	5.84	6.45	5.92	0.0270268868432813	4.43319157149538	0.756869566541066	0.938469876083733	15:71096951-71783383:+	THSD4	9;GO:0001527,cellular_component microfibril;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0031012,cellular_component extracellular matrix;GO:0048251,biological_process elastic fiber assembly;GO:0070062,cellular_component extracellular exosome	NA	thrombospondin type 1 domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25835]
ENSG00000166845	2.92	4.24	2.95	3.98	2.47	4.18	-0.0782970462179223	2.4965013361571	0.757009678401719	0.938476424230006	18:54357916-54385218:+	C18orf54	3;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0008285,biological_process negative regulation of cell proliferation	NA	chromosome 18 open reading frame 54 [Source:HGNC Symbol%3BAcc:HGNC:13796]
ENSG00000175137	15.75	16.13	14.86	15.43	17.50	15.21	-0.0321546081852465	4.23170404277079	0.757030496548978	0.938476424230006	1:248810445-248826633:-	SH3BP5L	6;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0017124,molecular_function SH3 domain binding;GO:0035556,biological_process intracellular signal transduction;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity	NA	SH3 binding domain protein 5 like [Source:HGNC Symbol%3BAcc:HGNC:29360]
ENSG00000077264	1.50	1.32	1.57	1.25	1.83	1.62	-0.0766332818252242	1.48454018687668	0.757101660536476	0.938476424230006	X:110944284-111227361:+	PAK3	50;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003824,molecular_function catalytic activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007266,biological_process Rho protein signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007409,biological_process axonogenesis;GO:0008152,biological_process metabolic process;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0010975,biological_process regulation of neuron projection development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016358,biological_process dendrite development;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0017048,molecular_function Rho GTPase binding;GO:0017124,molecular_function SH3 domain binding;GO:0030833,biological_process regulation of actin filament polymerization;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031295,biological_process T cell costimulation;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0042981,biological_process regulation of apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0050770,biological_process regulation of axonogenesis;GO:0050808,biological_process synapse organization;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051020,molecular_function GTPase binding;GO:0060996,biological_process dendritic spine development;GO:0060997,biological_process dendritic spine morphogenesis;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0071407,biological_process cellular response to organic cyclic compound;GO:2000573,biological_process positive regulation of DNA biosynthetic process	PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]; K05733	p21 (RAC1) activated kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:8592]
ENSG00000147457	9.49	11.50	9.47	11.45	9.81	10.17	-0.0423938972112459	4.02664122785782	0.757179448848236	0.938479131158577	8:23243636-23262000:+	CHMP7	23;GO:0000785,cellular_component chromatin;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007080,biological_process mitotic metaphase plate congression;GO:0008565,molecular_function protein transporter activity;GO:0010458,biological_process exit from mitosis;GO:0015031,biological_process protein transport;GO:0016197,biological_process endosomal transport;GO:0019058,biological_process viral life cycle;GO:0031468,biological_process nuclear envelope reassembly;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0045324,biological_process late endosome to vacuole transport;GO:0071168,biological_process protein localization to chromatin;GO:1904903,biological_process ESCRT III complex disassembly	CHMP7; charged multivesicular body protein 7; K15053	charged multivesicular body protein 7 [Source:HGNC Symbol%3BAcc:HGNC:28439]
ENSG00000116062	30.19	31.08	30.46	32.60	28.96	32.26	-0.0213627599272636	6.99587578824963	0.757369939384457	0.938621511339783	2:47695529-47810101:+	MSH6	42;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000400,molecular_function four-way junction DNA binding;GO:0000710,biological_process meiotic mismatch repair;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008340,biological_process determination of adult lifespan;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009411,biological_process response to UV;GO:0016032,biological_process viral process;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016447,biological_process somatic recombination of immunoglobulin gene segments;GO:0016887,molecular_function ATPase activity;GO:0030983,molecular_function mismatched DNA binding;GO:0032137,molecular_function guanine/thymine mispair binding;GO:0032142,molecular_function single guanine insertion binding;GO:0032143,molecular_function single thymine insertion binding;GO:0032301,cellular_component MutSalpha complex;GO:0032357,molecular_function oxidized purine DNA binding;GO:0032405,molecular_function MutLalpha complex binding;GO:0035064,molecular_function methylated histone binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043531,molecular_function ADP binding;GO:0045190,biological_process isotype switching;GO:0045830,biological_process positive regulation of isotype switching;GO:0045910,biological_process negative regulation of DNA recombination;GO:0051096,biological_process positive regulation of helicase activity;GO:0097193,biological_process intrinsic apoptotic signaling pathway	MSH6; DNA mismatch repair protein MSH6; K08737	mutS homolog 6 [Source:HGNC Symbol%3BAcc:HGNC:7329]
ENSG00000099785	11.87	12.56	14.16	13.59	12.23	11.91	0.0457596217512641	3.25417914271428	0.757588352386654	0.938676059478024	19:8413269-8439017:+	MARCH2	16;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006897,biological_process endocytosis;GO:0008270,molecular_function zinc ion binding;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0046872,molecular_function metal ion binding	NA	membrane associated ring-CH-type finger 2 [Source:HGNC Symbol%3BAcc:HGNC:28038]
ENSG00000023697	53.38	54.34	55.63	55.71	52.79	53.84	0.0205657920763554	5.79578774397428	0.757708565291817	0.938676059478024	12:15911171-16037282:+	DERA	16;GO:0003824,molecular_function catalytic activity;GO:0004139,molecular_function deoxyribose-phosphate aldolase activity;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006098,biological_process pentose-phosphate shunt;GO:0009264,biological_process deoxyribonucleotide catabolic process;GO:0016052,biological_process carbohydrate catabolic process;GO:0016829,molecular_function lyase activity;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046121,biological_process deoxyribonucleoside catabolic process;GO:0046386,biological_process deoxyribose phosphate catabolic process;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]; K01619	deoxyribose-phosphate aldolase [Source:HGNC Symbol%3BAcc:HGNC:24269]
ENSG00000144021	41.11	41.53	40.89	43.51	42.96	40.03	-0.0223951235299115	5.41104553581723	0.757846482622229	0.938676059478024	2:96266131-96273349:+	CIAO1	7;GO:0005515,molecular_function protein binding;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007059,biological_process chromosome segregation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0071817,cellular_component MMXD complex;GO:0097361,cellular_component CIA complex	NA	cytosolic iron-sulfur assembly component 1 [Source:HGNC Symbol%3BAcc:HGNC:14280]
ENSG00000170113	6.26	7.84	8.32	8.19	6.36	7.22	0.0480086049630611	2.9908084268051	0.757979713983588	0.938676059478024	15:22773062-22829791:+	NIPA1	11;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:1903830,biological_process magnesium ion transmembrane transport	NA	non imprinted in Prader-Willi/Angelman syndrome 1 [Source:HGNC Symbol%3BAcc:HGNC:17043]
ENSG00000134644	28.95	31.32	31.07	30.36	32.78	30.28	-0.0213793747056363	6.86199965549079	0.757993821265606	0.938676059478024	1:30931505-31065991:-	PUM1	24;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0007283,biological_process spermatogenesis;GO:0008344,biological_process adult locomotory behavior;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0016441,biological_process posttranscriptional gene silencing;GO:0016607,cellular_component nuclear speck;GO:0030154,biological_process cell differentiation;GO:0043488,biological_process regulation of mRNA stability;GO:0048863,biological_process stem cell differentiation;GO:0051726,biological_process regulation of cell cycle;GO:0051983,biological_process regulation of chromosome segregation;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0061157,biological_process mRNA destabilization;GO:1900246,biological_process positive regulation of RIG-I signaling pathway;GO:2000637,biological_process positive regulation of gene silencing by miRNA	NA	pumilio RNA binding family member 1 [Source:HGNC Symbol%3BAcc:HGNC:14957]
ENSG00000196460	1.51	1.28	1.08	1.64	0.65	1.33	0.104858627059414	1.13988003983699	0.757998806881118	0.938676059478024	2:101397360-101474703:-	RFX8	7;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter	NA	RFX family member 8%2C lacking RFX DNA binding domain [Source:HGNC Symbol%3BAcc:HGNC:37253]
ENSG00000197016	3.72	3.22	3.11	4.14	3.48	2.91	-0.0490362691917178	2.96157947440759	0.758036193189412	0.938676059478024	19:56567510-56588911:+	ZNF470	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016604,cellular_component nuclear body;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 470 [Source:HGNC Symbol%3BAcc:HGNC:22220]
ENSG00000034152	10.58	9.94	9.22	9.24	10.97	9.04	0.038047125154567	3.94229607341433	0.758245001127921	0.938676059478024	17:21284671-21315240:+	MAP2K3	32;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0035897,biological_process proteolysis in other organism;GO:0042035,biological_process regulation of cytokine biosynthetic process;GO:0042981,biological_process regulation of apoptotic process;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0060048,biological_process cardiac muscle contraction	MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]; K04432	mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:6843]
ENSG00000118197	7.83	7.74	7.54	8.79	7.42	7.66	-0.0345295308249065	4.08536332110246	0.758318199018561	0.938676059478024	1:200623895-200669969:-	DDX59	15;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	DEAD-box helicase 59 [Source:HGNC Symbol%3BAcc:HGNC:25360]
ENSG00000122779	18.56	18.72	17.78	16.31	20.13	18.13	0.0245308369425399	5.85090869611747	0.758378939928062	0.938676059478024	7:138460333-138589993:+	TRIM24	42;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005719,cellular_component nuclear euchromatin;GO:0005726,cellular_component perichromatin fibrils;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030163,biological_process protein catabolic process;GO:0031647,biological_process regulation of protein stability;GO:0034056,molecular_function estrogen response element binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0055074,biological_process calcium ion homeostasis;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070562,biological_process regulation of vitamin D receptor signaling pathway;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0071391,biological_process cellular response to estrogen stimulus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	tripartite motif containing 24 [Source:HGNC Symbol%3BAcc:HGNC:11812]
ENSG00000172594	12.26	11.39	14.30	12.40	10.77	14.13	0.0404266485321099	4.10914059760502	0.758431820496135	0.938676059478024	6:122789048-122809720:+	SMPDL3A	10;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0009143,biological_process nucleoside triphosphate catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	sphingomyelin phosphodiesterase acid like 3A [Source:HGNC Symbol%3BAcc:HGNC:17389]
ENSG00000118276	1.72	1.75	1.48	1.76	1.26	1.59	0.105486295954843	0.982841077672059	0.758436744470251	0.938676059478024	18:31622246-31685836:-	B4GALT6	14;GO:0000139,cellular_component Golgi membrane;GO:0001572,biological_process lactosylceramide biosynthetic process;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding	B4GALT6; beta-1,4-galactosyltransferase 6 [EC:2.4.1.274]; K07553	beta-1%2C4-galactosyltransferase 6 [Source:HGNC Symbol%3BAcc:HGNC:929]
ENSG00000163162	80.52	71.11	82.42	84.51	73.88	81.65	-0.0226163498279189	6.61304883768713	0.758455427493709	0.938676059478024	2:101271218-101308701:-	RNF149	10;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031647,biological_process regulation of protein stability;GO:0035690,biological_process cellular response to drug;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome	NA	ring finger protein 149 [Source:HGNC Symbol%3BAcc:HGNC:23137]
ENSG00000083844	5.07	3.91	3.41	4.48	3.82	3.75	0.0579447655614166	3.06053645937467	0.758472639697461	0.938676059478024	19:57191499-57222846:+	ZNF264	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 264 [Source:HGNC Symbol%3BAcc:HGNC:13057]
ENSG00000074590	4.63	5.35	4.97	4.57	4.74	5.32	0.0335063968702126	3.30929297956975	0.758704531199464	0.93874367258811	12:106063339-106140033:-	NUAK1	24;GO:0000166,molecular_function nucleotide binding;GO:0001650,cellular_component fibrillar center;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007155,biological_process cell adhesion;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030155,biological_process regulation of cell adhesion;GO:0035507,biological_process regulation of myosin-light-chain-phosphatase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042127,biological_process regulation of cell proliferation;GO:0046872,molecular_function metal ion binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2000772,biological_process regulation of cellular senescence	NA	NUAK family kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:14311]
ENSG00000112695	135.02	154.14	130.96	138.81	141.64	135.98	0.021249229013013	6.36156552593001	0.758765795404298	0.93874367258811	6:75237674-75250323:-	COX7A2	8;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	COX7A; cytochrome c oxidase subunit 7a; K02270	cytochrome c oxidase subunit 7A2 [Source:HGNC Symbol%3BAcc:HGNC:2288]
ENSG00000272047	162.80	178.12	149.97	163.10	176.61	163.42	-0.0285555318286342	5.14581091922717	0.758823586977002	0.93874367258811	6:158168351-158199344:+	GTF2H5	29;GO:0000182,molecular_function rDNA binding;GO:0000439,cellular_component core TFIIH complex;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006364,biological_process rRNA processing;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0071480,biological_process cellular response to gamma radiation	NA	general transcription factor IIH subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:21157]
ENSG00000177548	6.53	7.04	6.63	6.11	7.14	6.58	0.0346940377002896	3.57345348091901	0.758904043861499	0.93874367258811	16:28904420-28936526:-	RABEP2	11;GO:0005096,molecular_function GTPase activator activity;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0008083,molecular_function growth factor activity;GO:0015031,biological_process protein transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity	NA	rabaptin%2C RAB GTPase binding effector protein 2 [Source:HGNC Symbol%3BAcc:HGNC:24817]
ENSG00000134255	36.50	39.21	35.92	37.08	35.31	41.98	-0.0269547377738785	5.55964766381334	0.758905401951316	0.93874367258811	1:111139626-111185102:+	CEPT1	16;GO:0004142,molecular_function diacylglycerol cholinephosphotransferase activity;GO:0004307,molecular_function ethanolaminephosphotransferase activity;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006657,biological_process CDP-choline pathway;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016780,molecular_function phosphotransferase activity, for other substituted phosphate groups;GO:0031965,cellular_component nuclear membrane;GO:0046872,molecular_function metal ion binding	CEPT1; choline/ethanolamine phosphotransferase [EC:2.7.8.1 2.7.8.2]; K13644	choline/ethanolamine phosphotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:24289]
ENSG00000111328	64.74	67.28	59.22	64.33	62.77	61.83	0.0252863866793107	4.47131376957024	0.759040117016522	0.938816756927669	12:123260970-123272334:-	CDK2AP1	9;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006261,biological_process DNA-dependent DNA replication;GO:0007049,biological_process cell cycle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070182,molecular_function DNA polymerase binding	NA	cyclin dependent kinase 2 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:14002]
ENSG00000142627	40.16	35.54	37.68	39.84	35.75	40.56	-0.0216603696399993	6.81128435037312	0.759219973548189	0.938932802867221	1:16124336-16156087:-	EPHA2	77;GO:0000166,molecular_function nucleotide binding;GO:0001501,biological_process skeletal system development;GO:0001525,biological_process angiogenesis;GO:0001568,biological_process blood vessel development;GO:0001570,biological_process vasculogenesis;GO:0001618,molecular_function virus receptor activity;GO:0001649,biological_process osteoblast differentiation;GO:0001818,biological_process negative regulation of cytokine production;GO:0002043,biological_process blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005003,molecular_function ephrin receptor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009986,cellular_component cell surface;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0014028,biological_process notochord formation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0021915,biological_process neural tube development;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030316,biological_process osteoclast differentiation;GO:0031256,cellular_component leading edge membrane;GO:0031258,cellular_component lamellipodium membrane;GO:0032587,cellular_component ruffle membrane;GO:0032682,biological_process negative regulation of chemokine production;GO:0033598,biological_process mammary gland epithelial cell proliferation;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0036342,biological_process post-anal tail morphogenesis;GO:0042995,cellular_component cell projection;GO:0043491,biological_process protein kinase B signaling;GO:0043535,biological_process regulation of blood vessel endothelial cell migration;GO:0045296,molecular_function cadherin binding;GO:0045765,biological_process regulation of angiogenesis;GO:0046058,biological_process cAMP metabolic process;GO:0046718,biological_process viral entry into host cell;GO:0046849,biological_process bone remodeling;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048320,biological_process axial mesoderm formation;GO:0048514,biological_process blood vessel morphogenesis;GO:0048570,biological_process notochord morphogenesis;GO:0048870,biological_process cell motility;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060035,biological_process notochord cell development;GO:0060326,biological_process cell chemotaxis;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0070309,biological_process lens fiber cell morphogenesis;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0070848,biological_process response to growth factor;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0090630,biological_process activation of GTPase activity;GO:1901491,biological_process negative regulation of lymphangiogenesis;GO:1904238,biological_process pericyte cell differentiation	EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]; K05103	EPH receptor A2 [Source:HGNC Symbol%3BAcc:HGNC:3386]
ENSG00000150764	7.13	7.36	7.91	7.73	6.87	7.46	0.0332861322746289	3.99534319284718	0.759389892215238	0.938932802867221	11:111927143-112022584:+	DIXDC1	21;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0016055,biological_process Wnt signaling pathway;GO:0019904,molecular_function protein domain specific binding;GO:0021795,biological_process cerebral cortex cell migration;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0021846,biological_process cell proliferation in forebrain;GO:0021869,biological_process forebrain ventricular zone progenitor cell division;GO:0030054,cellular_component cell junction;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0043015,molecular_function gamma-tubulin binding;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	NA	DIX domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23695]
ENSG00000129351	106.59	110.14	100.16	105.56	116.99	101.73	-0.0218548148621966	8.2666273750691	0.759412921254333	0.938932802867221	19:10654260-10692417:+	ILF3	19;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051607,biological_process defense response to virus	NA	interleukin enhancer binding factor 3 [Source:HGNC Symbol%3BAcc:HGNC:6038]
ENSG00000161547	85.75	103.78	86.37	81.65	100.21	90.58	0.0264595923317369	5.9227396965426	0.759492638110044	0.938932802867221	17:76734114-76737374:-	SRSF2	25;GO:0000278,biological_process mitotic cell cycle;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0033197,biological_process response to vitamin E;GO:0035061,cellular_component interchromatin granule;GO:0036002,molecular_function pre-mRNA binding;GO:0043484,biological_process regulation of RNA splicing;GO:0070062,cellular_component extracellular exosome;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	SFRS2; splicing factor, arginine/serine-rich 2; K12891	serine and arginine rich splicing factor 2 [Source:HGNC Symbol%3BAcc:HGNC:10783]
ENSG00000103512	55.06	54.92	53.72	54.57	55.04	53.36	0.0181770987856934	7.69540955534101	0.759556667009546	0.938932802867221	16:14833680-14896160:+	NOMO1	5;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding	NA	NODAL modulator 1 [Source:HGNC Symbol%3BAcc:HGNC:30060]
ENSG00000171150	13.57	13.97	14.74	13.27	14.86	15.35	-0.0293241889879609	4.5334524874518	0.759587787512498	0.938932802867221	2:46698951-46763129:+	SOCS5	25;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0007259,biological_process JAK-STAT cascade;GO:0009968,biological_process negative regulation of signal transduction;GO:0016049,biological_process cell growth;GO:0016567,biological_process protein ubiquitination;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0035556,biological_process intracellular signal transduction;GO:0040008,biological_process regulation of growth;GO:0043687,biological_process post-translational protein modification;GO:0045627,biological_process positive regulation of T-helper 1 cell differentiation;GO:0045629,biological_process negative regulation of T-helper 2 cell differentiation;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0050728,biological_process negative regulation of inflammatory response;GO:0071404,biological_process cellular response to low-density lipoprotein particle stimulus;GO:0071638,biological_process negative regulation of monocyte chemotactic protein-1 production;GO:0097699,biological_process vascular endothelial cell response to fluid shear stress	SOCS5; suppressor of cytokine signaling 5; K04698	suppressor of cytokine signaling 5 [Source:HGNC Symbol%3BAcc:HGNC:16852]
ENSG00000166341	0.30	0.35	0.36	0.38	0.42	0.27	-0.0784941140316679	1.8325565790058	0.759829416915137	0.939137961980244	11:6621322-6655854:-	DCHS1	29;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001822,biological_process kidney development;GO:0003007,biological_process heart morphogenesis;GO:0003183,biological_process mitral valve morphogenesis;GO:0003192,biological_process mitral valve formation;GO:0003273,biological_process cell migration involved in endocardial cushion formation;GO:0005509,molecular_function calcium ion binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007389,biological_process pattern specification process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016477,biological_process cell migration;GO:0021915,biological_process neural tube development;GO:0022008,biological_process neurogenesis;GO:0035329,biological_process hippo signaling;GO:0036342,biological_process post-anal tail morphogenesis;GO:0043931,biological_process ossification involved in bone maturation;GO:0045177,cellular_component apical part of cell;GO:0048565,biological_process digestive tract development;GO:0072006,biological_process nephron development;GO:0072137,biological_process condensed mesenchymal cell proliferation;GO:0072659,biological_process protein localization to plasma membrane;GO:0090102,biological_process cochlea development;GO:0098609,biological_process cell-cell adhesion	DCHS1_2, PCDH16_23; protocadherin-16/23; K16507	dachsous cadherin-related 1 [Source:HGNC Symbol%3BAcc:HGNC:13681]
ENSG00000046647	22.67	20.14	20.99	19.18	22.36	21.41	0.0360026331915659	3.95584861200157	0.760446468666449	0.939762779697734	X:14008278-14029893:-	GEMIN8	12;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0097504,cellular_component Gemini of coiled bodies	GEMIN8; gem associated protein 8; K13136	gem nuclear organelle associated protein 8 [Source:HGNC Symbol%3BAcc:HGNC:26044]
ENSG00000128908	10.87	11.04	10.72	10.56	11.15	11.67	-0.0220543403956084	5.71043568789459	0.760486354794469	0.939762779697734	15:40978879-41116354:-	INO80	37;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003779,molecular_function actin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0010571,biological_process positive regulation of nuclear cell cycle DNA replication;GO:0016579,biological_process protein deubiquitination;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0030307,biological_process positive regulation of cell growth;GO:0031011,cellular_component Ino80 complex;GO:0032508,biological_process DNA duplex unwinding;GO:0034644,biological_process cellular response to UV;GO:0043014,molecular_function alpha-tubulin binding;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070914,biological_process UV-damage excision repair;GO:0071479,biological_process cellular response to ionizing radiation;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	NA	INO80 complex subunit [Source:HGNC Symbol%3BAcc:HGNC:26956]
ENSG00000125450	22.87	26.81	24.63	26.27	23.81	23.46	0.0229179834613731	5.65123743374857	0.760880080804629	0.940146724252015	17:75205658-75235758:+	NUP85	36;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006935,biological_process chemotaxis;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0030032,biological_process lamellipodium assembly;GO:0031080,cellular_component nuclear pore outer ring;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048246,biological_process macrophage chemotaxis;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP85; nuclear pore complex protein Nup85; K14304	nucleoporin 85 [Source:HGNC Symbol%3BAcc:HGNC:8734]
ENSG00000166206	2.13	1.90	2.89	2.58	2.16	2.61	-0.0636129030255181	2.20352913319016	0.7609485328736	0.940146724252015	15:26543545-26939539:-	GABRB3	34;GO:0004890,molecular_function GABA-A receptor activity;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0007165,biological_process signal transduction;GO:0007214,biological_process gamma-aminobutyric acid signaling pathway;GO:0007605,biological_process sensory perception of sound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022851,molecular_function GABA-gated chloride ion channel activity;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034220,biological_process ion transmembrane transport;GO:0034707,cellular_component chloride channel complex;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048666,biological_process neuron development;GO:0060021,biological_process palate development;GO:0060080,biological_process inhibitory postsynaptic potential;GO:0060119,biological_process inner ear receptor cell development;GO:0060384,biological_process innervation;GO:0071420,biological_process cellular response to histamine;GO:0090102,biological_process cochlea development;GO:1901215,biological_process negative regulation of neuron death;GO:1902476,biological_process chloride transmembrane transport;GO:1902711,cellular_component GABA-A receptor complex	GABRB; gamma-aminobutyric acid receptor subunit beta; K05181	gamma-aminobutyric acid type A receptor beta3 subunit [Source:HGNC Symbol%3BAcc:HGNC:4083]
ENSG00000265354	61.28	66.00	69.49	67.95	69.19	64.49	-0.0238706162606173	5.38529470068671	0.761028584384712	0.940152051947396	10:45972448-46003734:+	TIMM23	15;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0015450,molecular_function P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031305,cellular_component integral component of mitochondrial inner membrane	NA	translocase of inner mitochondrial membrane 23 [Source:HGNC Symbol%3BAcc:HGNC:17312]
ENSG00000007080	83.19	80.71	69.97	75.32	85.37	79.15	-0.0254935284492618	5.72742940833566	0.76135257879668	0.940337129803412	19:17933015-17943991:+	CCDC124	7;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0030496,cellular_component midbody;GO:0051301,biological_process cell division	NA	coiled-coil domain containing 124 [Source:HGNC Symbol%3BAcc:HGNC:25171]
ENSG00000106006	3.84	3.69	4.63	4.50	3.69	3.42	0.0890591979917129	1.54894872116098	0.761400811035932	0.940337129803412	7:27145395-27150603:-	HOXA6	10;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development	NA	homeobox A6 [Source:HGNC Symbol%3BAcc:HGNC:5107]
ENSG00000132819	4.86	4.93	3.99	3.66	4.21	6.79	-0.0884017150537962	1.90587346141768	0.76144799312871	0.940337129803412	20:57391406-57409333:+	RBM38	12;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0007049,biological_process cell cycle;GO:0008380,biological_process RNA splicing;GO:0010830,biological_process regulation of myotube differentiation;GO:0030154,biological_process cell differentiation;GO:0043484,biological_process regulation of RNA splicing	NA	RNA binding motif protein 38 [Source:HGNC Symbol%3BAcc:HGNC:15818]
ENSG00000256537	44.31	44.50	45.82	43.31	41.64	46.88	0.0407579229562286	3.20481454247324	0.761481416964787	0.940337129803412	12:11171221-11176016:+	SMIM10L1	NA	NA	small integral membrane protein 10 like 1 [Source:HGNC Symbol%3BAcc:HGNC:49847]
ENSG00000165915	31.90	30.32	32.32	31.82	32.57	32.44	-0.0202830349276418	5.43088811461009	0.76161543665576	0.940392226305563	11:47407131-47416501:+	SLC39A13	20;GO:0000139,cellular_component Golgi membrane;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006829,biological_process zinc II ion transport;GO:0006882,biological_process cellular zinc ion homeostasis;GO:0010043,biological_process response to zinc ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030001,biological_process metal ion transport;GO:0030173,cellular_component integral component of Golgi membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0046873,molecular_function metal ion transmembrane transporter activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055085,biological_process transmembrane transport;GO:0061448,biological_process connective tissue development;GO:0071577,biological_process zinc II ion transmembrane transport	NA	solute carrier family 39 member 13 [Source:HGNC Symbol%3BAcc:HGNC:20859]
ENSG00000108312	50.76	51.31	49.08	52.03	50.83	51.52	-0.0192511809687518	6.92732788647554	0.761727725935053	0.940392226305563	17:44205032-44221626:-	UBTF	18;GO:0001164,molecular_function RNA polymerase I CORE element sequence-specific DNA binding;GO:0001165,molecular_function RNA polymerase I upstream control element sequence-specific DNA binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006356,biological_process regulation of transcription from RNA polymerase I promoter;GO:0006360,biological_process transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter	NA	upstream binding transcription factor%2C RNA polymerase I [Source:HGNC Symbol%3BAcc:HGNC:12511]
ENSG00000175294	2.35	1.92	2.48	2.37	2.04	2.19	0.0591634800174638	2.43071263216401	0.761814381197769	0.940392226305563	11:66016751-66026517:-	CATSPER1	30;GO:0005216,molecular_function ion channel activity;GO:0005227,molecular_function calcium activated cation channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007342,biological_process fusion of sperm to egg plasma membrane;GO:0008331,molecular_function high voltage-gated calcium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0032570,biological_process response to progesterone;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035036,biological_process sperm-egg recognition;GO:0036128,cellular_component CatSper complex;GO:0042995,cellular_component cell projection;GO:0051924,biological_process regulation of calcium ion transport;GO:0055085,biological_process transmembrane transport;GO:0060296,biological_process regulation of cilium beat frequency involved in ciliary motility;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086010,biological_process membrane depolarization during action potential	NA	cation channel sperm associated 1 [Source:HGNC Symbol%3BAcc:HGNC:17116]
ENSG00000142583	2.46	1.15	2.21	2.25	2.42	1.65	-0.0735537953378264	1.83456407824281	0.761829068535305	0.940392226305563	1:9035106-9088478:-	SLC2A5	27;GO:0003044,biological_process regulation of systemic arterial blood pressure mediated by a chemical signal;GO:0005215,molecular_function transporter activity;GO:0005353,molecular_function fructose transmembrane transporter activity;GO:0005355,molecular_function glucose transmembrane transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0009750,biological_process response to fructose;GO:0015755,biological_process fructose transport;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0022891,molecular_function substrate-specific transmembrane transporter activity;GO:0035579,cellular_component specific granule membrane;GO:0042383,cellular_component sarcolemma;GO:0043312,biological_process neutrophil degranulation;GO:0055085,biological_process transmembrane transport;GO:0070061,molecular_function fructose binding;GO:0070062,cellular_component extracellular exosome;GO:0071332,biological_process cellular response to fructose stimulus;GO:0106001,biological_process intestinal hexose absorption;GO:1904659,biological_process glucose transmembrane transport;GO:1990539,biological_process fructose import across plasma membrane	SLC2A5, GLUT5; MFS transporter, SP family, solute carrier family 2 (facilitated glucose/fructose transporter), member 5; K08143	solute carrier family 2 member 5 [Source:HGNC Symbol%3BAcc:HGNC:11010]
ENSG00000197050	3.77	4.14	5.00	3.97	4.02	4.65	0.0423440259223973	3.3059684784269	0.762011269568142	0.9404825274487	19:37007856-37130314:+	ZNF420	12;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 420 [Source:HGNC Symbol%3BAcc:HGNC:20649]
ENSG00000081181	36.31	24.48	36.32	36.73	26.92	37.41	-0.0413845656885997	5.14717696770611	0.762092545729344	0.9404825274487	14:67619797-67651720:+	ARG2	11;GO:0000050,biological_process urea cycle;GO:0001657,biological_process ureteric bud development;GO:0004053,molecular_function arginase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006525,biological_process arginine metabolic process;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0006941,biological_process striated muscle contraction;GO:0016787,molecular_function hydrolase activity;GO:0016813,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines;GO:0046872,molecular_function metal ion binding	E3.5.3.1, rocF, arg; arginase [EC:3.5.3.1]; K01476	arginase 2 [Source:HGNC Symbol%3BAcc:HGNC:664]
ENSG00000100490	8.38	7.81	7.27	8.21	7.77	8.40	-0.0432503239930933	3.17645442898183	0.76212952095436	0.9404825274487	14:50329403-50416461:-	CDKL1	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007507,biological_process heart development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051726,biological_process regulation of cell cycle;GO:0070062,cellular_component extracellular exosome	NA	cyclin dependent kinase like 1 [Source:HGNC Symbol%3BAcc:HGNC:1781]
ENSG00000139323	7.23	7.19	7.08	7.10	5.55	8.33	0.0442327213043463	3.36874396798047	0.762428082654429	0.940694448136914	12:89419717-89526024:-	POC1B	12;GO:0000922,cellular_component spindle pole;GO:0001895,biological_process retina homeostasis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0008283,biological_process cell proliferation;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	POC1 centriolar protein B [Source:HGNC Symbol%3BAcc:HGNC:30836]
ENSG00000072818	3.40	2.78	2.86	3.40	2.58	3.47	-0.0483665547391799	2.84261514882828	0.762452819036936	0.940694448136914	17:7336528-7351478:+	ACAP1	10;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0055038,cellular_component recycling endosome membrane	ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein; K12489	ArfGAP with coiled-coil%2C ankyrin repeat and PH domains 1 [Source:HGNC Symbol%3BAcc:HGNC:16467]
ENSG00000162813	25.87	28.22	28.55	26.57	31.05	27.27	-0.0288086995146249	4.77012448140226	0.762677169765533	0.940798767235025	1:220057481-220090462:-	BPNT1	10;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0007399,biological_process nervous system development;GO:0008441,molecular_function 3'(2'),5'-bisphosphate nucleotidase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050427,biological_process 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0070062,cellular_component extracellular exosome	cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]; K01082	3'(2')%2C 5'-bisphosphate nucleotidase 1 [Source:HGNC Symbol%3BAcc:HGNC:1096]
ENSG00000105429	16.89	19.15	18.37	17.25	19.59	18.84	-0.0226207843614761	7.30076176120324	0.762688954699594	0.940798767235025	19:42325608-42378769:+	MEGF8	23;GO:0003143,biological_process embryonic heart tube morphogenesis;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007368,biological_process determination of left/right symmetry;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030509,biological_process BMP signaling pathway;GO:0035108,biological_process limb morphogenesis;GO:0042074,biological_process cell migration involved in gastrulation;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048842,biological_process positive regulation of axon extension involved in axon guidance;GO:0055113,biological_process epiboly involved in gastrulation with mouth forming second;GO:0060971,biological_process embryonic heart tube left/right pattern formation;GO:0060972,biological_process left/right pattern formation;GO:0060976,biological_process coronary vasculature development;GO:0061371,biological_process determination of heart left/right asymmetry;GO:0070062,cellular_component extracellular exosome;GO:0071907,biological_process determination of digestive tract left/right asymmetry;GO:0097094,biological_process craniofacial suture morphogenesis;GO:0097155,biological_process fasciculation of sensory neuron axon	NA	multiple EGF like domains 8 [Source:HGNC Symbol%3BAcc:HGNC:3233]
ENSG00000101104	17.00	14.47	18.99	19.36	14.40	18.45	-0.0335276643617991	5.16542771520647	0.763125543528049	0.941183034384556	20:44910061-44959035:+	PABPC1L	8;GO:0001556,biological_process oocyte maturation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0006338,biological_process chromatin remodeling;GO:0006378,biological_process mRNA polyadenylation;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0051647,biological_process nucleus localization;GO:0070062,cellular_component extracellular exosome	PABPC; polyadenylate-binding protein; K13126	poly(A) binding protein cytoplasmic 1 like [Source:HGNC Symbol%3BAcc:HGNC:15797]
ENSG00000167863	278.32	294.80	261.60	280.73	296.34	276.28	-0.0212529151366301	7.15814903038492	0.763152118027919	0.941183034384556	17:75038862-75046985:-	ATP5H	22;GO:0000274,cellular_component mitochondrial proton-transporting ATP synthase, stator stalk;GO:0000276,cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005829,cellular_component cytosol;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045263,cellular_component proton-transporting ATP synthase complex, coupling factor F(o);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF0D, ATP5H, ATP7; F-type H+-transporting ATPase subunit d; K02138	ATP synthase%2C H+ transporting%2C mitochondrial Fo complex subunit D [Source:HGNC Symbol%3BAcc:HGNC:845]
ENSG00000141858	21.09	19.10	18.40	19.35	18.84	22.08	-0.028718160936122	4.69362224282428	0.763288227454628	0.941247671495676	19:14087839-14091036:-	SAMD1	NA	NA	sterile alpha motif domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17958]
ENSG00000115942	17.42	18.99	16.37	17.60	17.92	18.52	-0.0284154719406768	4.95188317907096	0.76335618375469	0.941247671495676	2:200908972-200963680:-	ORC2	16;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0000792,cellular_component heterochromatin;GO:0000808,cellular_component origin recognition complex;GO:0000939,cellular_component condensed chromosome inner kinetochore;GO:0003688,molecular_function DNA replication origin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0005813,cellular_component centrosome;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0016020,cellular_component membrane	ORC2; origin recognition complex subunit 2; K02604	origin recognition complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:8488]
ENSG00000164885	20.40	23.78	20.08	22.56	22.16	21.27	-0.0352203405543906	4.25756993811225	0.763635024536047	0.941447663289019	7:151053811-151058530:-	CDK5	121;GO:0000166,molecular_function nucleotide binding;GO:0001764,biological_process neuron migration;GO:0001963,biological_process synaptic transmission, dopaminergic;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005176,molecular_function ErbB-2 class receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007160,biological_process cell-matrix adhesion;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0007416,biological_process synapse assembly;GO:0007519,biological_process skeletal muscle tissue development;GO:0008045,biological_process motor neuron axon guidance;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008283,biological_process cell proliferation;GO:0008306,biological_process associative learning;GO:0008542,biological_process visual learning;GO:0009611,biological_process response to wounding;GO:0014044,biological_process Schwann cell development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016533,cellular_component cyclin-dependent protein kinase 5 holoenzyme complex;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019233,biological_process sensory perception of pain;GO:0019901,molecular_function protein kinase binding;GO:0021537,biological_process telencephalon development;GO:0021549,biological_process cerebellum development;GO:0021695,biological_process cerebellar cortex development;GO:0021697,biological_process cerebellar cortex formation;GO:0021766,biological_process hippocampus development;GO:0021819,biological_process layer formation in cerebral cortex;GO:0021954,biological_process central nervous system neuron development;GO:0021987,biological_process cerebral cortex development;GO:0022038,biological_process corpus callosum development;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030182,biological_process neuron differentiation;GO:0030334,biological_process regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030517,biological_process negative regulation of axon extension;GO:0030549,molecular_function acetylcholine receptor activator activity;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0030900,biological_process forebrain development;GO:0031175,biological_process neuron projection development;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031594,cellular_component neuromuscular junction;GO:0031914,biological_process negative regulation of synaptic plasticity;GO:0032092,biological_process positive regulation of protein binding;GO:0032801,biological_process receptor catabolic process;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0035418,biological_process protein localization to synapse;GO:0042220,biological_process response to cocaine;GO:0042501,biological_process serine phosphorylation of STAT protein;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043113,biological_process receptor clustering;GO:0043125,molecular_function ErbB-3 class receptor binding;GO:0043204,cellular_component perikaryon;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045055,biological_process regulated exocytosis;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0045786,biological_process negative regulation of cell cycle;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045861,biological_process negative regulation of proteolysis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0046777,biological_process protein autophosphorylation;GO:0046826,biological_process negative regulation of protein export from nucleus;GO:0046875,molecular_function ephrin receptor binding;GO:0048148,biological_process behavioral response to cocaine;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0048511,biological_process rhythmic process;GO:0048675,biological_process axon extension;GO:0048709,biological_process oligodendrocyte differentiation;GO:0048812,biological_process neuron projection morphogenesis;GO:0048813,biological_process dendrite morphogenesis;GO:0050321,molecular_function tau-protein kinase activity;GO:0051301,biological_process cell division;GO:0051402,biological_process neuron apoptotic process;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060079,biological_process excitatory postsynaptic potential;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0070509,biological_process calcium ion import;GO:0071156,biological_process regulation of cell cycle arrest;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0098793,cellular_component presynapse;GO:1901215,biological_process negative regulation of neuron death;GO:1901216,biological_process positive regulation of neuron death;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1903421,biological_process regulation of synaptic vesicle recycling;GO:2000251,biological_process positive regulation of actin cytoskeleton reorganization;GO:2000273,biological_process positive regulation of receptor activity	CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]; K02090	cyclin dependent kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:1774]
ENSG00000214756	3.53	3.19	2.25	2.70	4.00	1.76	0.0992162346944699	1.15750045837359	0.763773979081924	0.941447663289019	11:62665308-62668496:+	METTL12	4;GO:0005739,cellular_component mitochondrion;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	methyltransferase like 12 [Source:HGNC Symbol%3BAcc:HGNC:33113]
ENSG00000119333	29.90	29.96	30.40	29.34	29.11	31.26	0.0200244882859241	5.71756372558192	0.763798026460029	0.941447663289019	9:128633660-128656787:-	WDR34	18;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042073,biological_process intraciliary transport;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045504,molecular_function dynein heavy chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0097014,cellular_component ciliary plasm;GO:0097542,cellular_component ciliary tip	NA	WD repeat domain 34 [Source:HGNC Symbol%3BAcc:HGNC:28296]
ENSG00000165219	13.16	11.89	12.42	12.36	12.08	12.83	0.0218417633789532	5.86075840754495	0.764061215947775	0.941447663289019	9:125261793-125367207:+	GAPVD1	14;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0032794,molecular_function GTPase activating protein binding;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045296,molecular_function cadherin binding;GO:0051223,biological_process regulation of protein transport;GO:0061024,biological_process membrane organization	NA	GTPase activating protein and VPS9 domains 1 [Source:HGNC Symbol%3BAcc:HGNC:23375]
ENSG00000088682	36.73	44.68	38.28	37.63	43.20	37.30	0.0255838015301979	5.26612324106047	0.764091917732954	0.941447663289019	16:57447424-57461275:+	COQ9	7;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0008289,molecular_function lipid binding;GO:0042803,molecular_function protein homodimerization activity	NA	coenzyme Q9 [Source:HGNC Symbol%3BAcc:HGNC:25302]
ENSG00000092148	31.07	28.82	29.97	28.84	30.49	30.14	0.0187628662556931	7.89416035655379	0.764186939250775	0.941447663289019	14:31100111-31207804:-	HECTD1	7;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	HECT domain E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:20157]
ENSG00000267221	0.49	0.76	0.44	0.48	0.60	0.45	0.109736455339774	0.283188337627467	0.764216948071573	0.941447663289019	17:42038231-42050614:-	C17orf113	NA	NA	chromosome 17 open reading frame 113 [Source:HGNC Symbol%3BAcc:HGNC:53437]
ENSG00000085274	13.54	12.16	12.63	12.65	12.11	13.21	0.0286093128450776	4.5659021131071	0.764237720096992	0.941447663289019	3:169772830-169789716:+	MYNN	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	myoneurin [Source:HGNC Symbol%3BAcc:HGNC:14955]
ENSG00000257727	3.97	2.60	2.40	4.08	2.89	2.81	-0.0906613818376963	0.915823088190872	0.764273848256381	0.941447663289019	12:56309841-56316336:-	CNPY2	8;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005887,cellular_component integral component of plasma membrane;GO:0007167,biological_process enzyme linked receptor protein signaling pathway;GO:0009888,biological_process tissue development;GO:0010629,biological_process negative regulation of gene expression;GO:0010988,biological_process regulation of low-density lipoprotein particle clearance;GO:0045716,biological_process positive regulation of low-density lipoprotein particle receptor biosynthetic process	NA	canopy FGF signaling regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:13529]
ENSG00000113441	4.32	5.00	4.28	4.60	4.27	4.48	0.0293020678164857	3.80020645059599	0.76427681486856	0.941447663289019	5:96935393-97037515:+	LNPEP	31;GO:0000209,biological_process protein polyubiquitination;GO:0002480,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0004177,molecular_function aminopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007565,biological_process female pregnancy;GO:0008217,biological_process regulation of blood pressure;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030163,biological_process protein catabolic process;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031905,cellular_component early endosome lumen;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0060395,biological_process SMAD protein signal transduction;GO:0061024,biological_process membrane organization;GO:0070006,molecular_function metalloaminopeptidase activity	LNPEP; cystinyl aminopeptidase [EC:3.4.11.3]; K01257	leucyl and cystinyl aminopeptidase [Source:HGNC Symbol%3BAcc:HGNC:6656]
ENSG00000118707	4.79	5.55	6.95	6.35	5.97	5.87	-0.05980296540213	2.33387730048501	0.764480004098269	0.941604513878926	20:36573487-36593950:+	TGIF2	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010470,biological_process regulation of gastrulation;GO:0038092,biological_process nodal signaling pathway;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0060041,biological_process retina development in camera-type eye	NA	TGFB induced factor homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:15764]
ENSG00000247626	3.22	3.38	3.10	2.78	3.24	3.36	0.0544424157219282	2.53684277149975	0.764557000804396	0.941605918343582	2:197705368-197708387:+	MARS2	11;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004825,molecular_function methionine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006431,biological_process methionyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]; K01874	methionyl-tRNA synthetase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:25133]
ENSG00000241258	9.02	7.19	9.88	7.47	7.20	10.47	0.0727528708728353	2.43645345088396	0.765157366945656	0.942251824989724	7:66114603-66154568:+	CRCP	23;GO:0000166,molecular_function nucleotide binding;GO:0001056,molecular_function RNA polymerase III activity;GO:0001635,molecular_function calcitonin gene-related peptide receptor activity;GO:0001669,cellular_component acrosomal vesicle;GO:0002376,biological_process immune system process;GO:0003824,molecular_function catalytic activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0006384,biological_process transcription initiation from RNA polymerase III promoter;GO:0007218,biological_process neuropeptide signaling pathway;GO:0009360,cellular_component DNA polymerase III complex;GO:0016020,cellular_component membrane;GO:0032481,biological_process positive regulation of type I interferon production;GO:0044237,biological_process cellular metabolic process;GO:0045087,biological_process innate immune response;GO:0051607,biological_process defense response to virus	NA	CGRP receptor component [Source:HGNC Symbol%3BAcc:HGNC:17888]
ENSG00000116273	20.09	14.33	17.91	18.97	15.34	17.19	0.0453517871276813	3.98322877418947	0.765550221892454	0.942572958807546	1:6613684-6624033:+	PHF13	12;GO:0000278,biological_process mitotic cell cycle;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007076,biological_process mitotic chromosome condensation;GO:0016569,biological_process covalent chromatin modification;GO:0030261,biological_process chromosome condensation;GO:0035064,molecular_function methylated histone binding;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	NA	PHD finger protein 13 [Source:HGNC Symbol%3BAcc:HGNC:22983]
ENSG00000185842	1.27	1.26	1.32	1.32	1.12	1.35	0.0310961961320112	4.27110685108124	0.765583719728923	0.942572958807546	1:224896261-225399292:+	DNAH14	16;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0030286,cellular_component dynein complex;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis	NA	dynein axonemal heavy chain 14 [Source:HGNC Symbol%3BAcc:HGNC:2945]
ENSG00000011405	17.39	15.74	16.83	15.39	17.71	16.55	0.0227924137609419	6.39642851869618	0.765742943828632	0.942572958807546	11:17077729-17207983:-	PIK3C2A	35;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005942,cellular_component phosphatidylinositol 3-kinase complex;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006887,biological_process exocytosis;GO:0006897,biological_process endocytosis;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0008286,biological_process insulin receptor signaling pathway;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014829,biological_process vascular smooth muscle contraction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0035004,molecular_function phosphatidylinositol 3-kinase activity;GO:0035005,molecular_function 1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048268,biological_process clathrin coat assembly;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	PIK3C2; phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]; K00923	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [Source:HGNC Symbol%3BAcc:HGNC:8971]
ENSG00000008513	23.68	17.80	22.66	23.56	20.08	19.65	0.0401799968325486	4.45336731548377	0.765755391466708	0.942572958807546	8:133454847-133571940:-	ST3GAL1	21;GO:0000139,cellular_component Golgi membrane;GO:0003836,molecular_function beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0006054,biological_process N-acetylneuraminate metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0032580,cellular_component Golgi cisterna membrane;GO:0070062,cellular_component extracellular exosome;GO:0097503,biological_process sialylation	SIAT4A; beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.99.4]; K00780	ST3 beta-galactoside alpha-2%2C3-sialyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:10862]
ENSG00000085644	6.75	4.46	7.08	5.72	6.28	5.92	0.058830063993147	3.13049355448943	0.765843810426759	0.942572958807546	16:3129776-3142805:+	ZNF213	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 213 [Source:HGNC Symbol%3BAcc:HGNC:13005]
ENSG00000163636	52.05	53.10	49.09	53.08	49.07	51.09	0.0194601404263649	6.12326166415379	0.765873750304753	0.942572958807546	3:64010548-64024010:-	PSMD6	39;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0016887,molecular_function ATPase activity;GO:0022624,cellular_component proteasome accessory complex;GO:0030234,molecular_function enzyme regulator activity;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050790,biological_process regulation of catalytic activity;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMD6, RPN7; 26S proteasome regulatory subunit N7; K03037	proteasome 26S subunit%2C non-ATPase 6 [Source:HGNC Symbol%3BAcc:HGNC:9564]
ENSG00000009790	1.37	1.86	1.91	1.89	0.94	1.99	0.0899973640087285	1.56788346216003	0.766028270244953	0.942626777382987	1:209756031-209782320:+	TRAF3IP3	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	TRAF3 interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:30766]
ENSG00000171931	1.02	0.69	0.75	0.92	0.68	0.74	0.0982921778915483	1.50372992988323	0.766069357144894	0.942626777382987	17:18744023-18779349:+	FBXW10	4;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	F-box and WD repeat domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:1211]
ENSG00000114999	15.05	15.80	17.18	17.15	16.43	15.85	-0.0288337052888825	4.21217236850935	0.766200693417961	0.942694935810997	2:112482153-112541739:+	TTL	7;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004835,molecular_function tubulin-tyrosine ligase activity;GO:0005524,molecular_function ATP binding;GO:0006464,biological_process cellular protein modification process;GO:0016874,molecular_function ligase activity;GO:0030516,biological_process regulation of axon extension	NA	tubulin tyrosine ligase [Source:HGNC Symbol%3BAcc:HGNC:21586]
ENSG00000167700	16.97	16.39	15.42	14.60	17.98	15.59	0.0308129003322462	4.33089811705158	0.766537938210531	0.942968294194248	8:144509073-144511213:+	MFSD3	7;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0015295,molecular_function solute:proton symporter activity;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	major facilitator superfamily domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25157]
ENSG00000186281	2.46	2.72	2.41	3.11	2.58	2.24	-0.0546683480010733	2.65560684421219	0.766638006427989	0.942968294194248	2:96021945-96039451:-	GPAT2	18;GO:0004366,molecular_function glycerol-3-phosphate O-acyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006072,biological_process glycerol-3-phosphate metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019432,biological_process triglyceride biosynthetic process;GO:0044255,biological_process cellular lipid metabolic process;GO:0102420,molecular_function sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity;GO:1990511,biological_process piRNA biosynthetic process	GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]; K00629	glycerol-3-phosphate acyltransferase 2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:27168]
ENSG00000119711	19.98	17.74	18.80	18.43	20.46	19.19	-0.0225866685101572	4.94792101433922	0.766654343940631	0.942968294194248	14:74056849-74084493:-	ALDH6A1	17;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0003723,molecular_function RNA binding;GO:0004491,molecular_function methylmalonate-semialdehyde dehydrogenase (acylating) activity;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006210,biological_process thymine catabolic process;GO:0006573,biological_process valine metabolic process;GO:0006574,biological_process valine catabolic process;GO:0008152,biological_process metabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0018478,molecular_function malonate-semialdehyde dehydrogenase (acetylating) activity;GO:0019859,biological_process thymine metabolic process;GO:0050873,biological_process brown fat cell differentiation;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	mmsA, iolA, ALDH6A1; malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]; K00140	aldehyde dehydrogenase 6 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:7179]
ENSG00000178904	5.54	6.83	5.16	5.84	6.32	5.92	-0.0444488028060689	3.76926248608741	0.766810638438735	0.942968294194248	19:32405542-32485895:+	DPY19L3	7;GO:0000030,molecular_function mannosyltransferase activity;GO:0005637,cellular_component nuclear inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018406,biological_process protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	NA	dpy-19 like 3 (C. elegans) [Source:HGNC Symbol%3BAcc:HGNC:27120]
ENSG00000178764	104.77	98.23	103.97	103.05	104.11	106.19	-0.0173342883351195	8.02217226614175	0.766851474678801	0.942968294194248	8:122781393-122974512:+	ZHX2	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006402,biological_process mRNA catabolic process;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045665,biological_process negative regulation of neuron differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	NA	zinc fingers and homeoboxes 2 [Source:HGNC Symbol%3BAcc:HGNC:18513]
ENSG00000175970	23.54	30.46	29.03	29.53	29.21	26.71	-0.036009938459565	4.40908951691072	0.766878669934015	0.942968294194248	12:120710434-120723640:+	UNC119B	13;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0030030,biological_process cell projection organization;GO:0030182,biological_process neuron differentiation;GO:0035869,cellular_component ciliary transition zone;GO:0042953,biological_process lipoprotein transport;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis	NA	unc-119 lipid binding chaperone B [Source:HGNC Symbol%3BAcc:HGNC:16488]
ENSG00000205423	16.91	21.31	18.83	21.79	15.31	18.16	0.0477708271487267	3.01667478741461	0.767046279564584	0.94302376875779	16:50024409-50037088:+	CNEP1R1	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0034504,biological_process protein localization to nucleus;GO:0035307,biological_process positive regulation of protein dephosphorylation;GO:0071595,cellular_component Nem1-Spo7 phosphatase complex	NA	CTD nuclear envelope phosphatase 1 regulatory subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:26759]
ENSG00000105983	26.59	26.39	28.11	25.79	29.65	24.98	0.0254034032648817	5.48299651827443	0.76707572650829	0.94302376875779	7:156668945-156893230:-	LMBR1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042733,biological_process embryonic digit morphogenesis	NA	limb development membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:13243]
ENSG00000166387	0.17	0.48	0.42	0.35	0.36	0.24	0.151598623694332	0.174221689182206	0.767430853857539	0.943366923047497	11:7513297-7657127:+	PPFIBP2	5;GO:0003674,molecular_function molecular_function;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0042802,molecular_function identical protein binding	NA	PPFIA binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9250]
ENSG00000183668	0.78	2.49	1.49	1.81	2.52	0.87	-0.134213767334636	1.39463880075656	0.7676912564751	0.94359358021838	19:43211790-43269530:-	PSG9	2;GO:0005576,cellular_component extracellular region;GO:0007565,biological_process female pregnancy	NA	pregnancy specific beta-1-glycoprotein 9 [Source:HGNC Symbol%3BAcc:HGNC:9526]
ENSG00000182134	7.84	9.63	7.54	8.27	8.42	9.05	-0.0420393450731838	3.98888843932367	0.767845601425715	0.94364829423693	1:151770106-151791416:-	TDRKH	15;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0007140,biological_process male meiosis;GO:0007283,biological_process spermatogenesis;GO:0009566,biological_process fertilization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0031047,biological_process gene silencing by RNA;GO:0034587,biological_process piRNA metabolic process;GO:0043046,biological_process DNA methylation involved in gamete generation;GO:0071546,cellular_component pi-body;GO:0071547,cellular_component piP-body	NA	tudor and KH domain containing [Source:HGNC Symbol%3BAcc:HGNC:11713]
ENSG00000163754	16.83	17.85	17.40	17.84	16.84	18.79	-0.0301154719653136	4.29641040286004	0.768074616055824	0.94364829423693	3:148991340-149027668:+	GYG1	16;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005978,biological_process glycogen biosynthetic process;GO:0005980,biological_process glycogen catabolic process;GO:0008466,molecular_function glycogenin glucosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0034774,cellular_component secretory granule lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0102751,molecular_function UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity;GO:1904813,cellular_component ficolin-1-rich granule lumen	GYG1, GYG2; glycogenin [EC:2.4.1.186]; K00750	glycogenin 1 [Source:HGNC Symbol%3BAcc:HGNC:4699]
ENSG00000170471	14.10	13.40	14.07	13.56	15.05	13.91	-0.0193326054128692	5.98181283626459	0.768123385846032	0.94364829423693	20:38472815-38578861:+	RALGAPB	5;GO:0005096,molecular_function GTPase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0090630,biological_process activation of GTPase activity	NA	Ral GTPase activating protein non-catalytic beta subunit [Source:HGNC Symbol%3BAcc:HGNC:29221]
ENSG00000179240	3.08	3.12	3.13	3.41	2.78	2.78	0.0688146801149727	1.69187577951635	0.768191945788931	0.94364829423693	11:76381312-76414619:+	AP002360.1	NA	NA	NA
ENSG00000175130	51.07	61.75	61.52	56.95	63.01	58.90	-0.029054854022347	5.1110618788929	0.76821106894481	0.94364829423693	1:32333831-32336379:-	MARCKSL1	8;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	MARCKSL1, MRP; MARCKS-related protein; K13536	MARCKS like 1 [Source:HGNC Symbol%3BAcc:HGNC:7142]
ENSG00000068697	484.38	512.42	475.41	487.79	534.15	482.27	-0.0196390617090387	8.43916298500294	0.768247614249283	0.94364829423693	2:20032649-20052028:-	LAPTM4A	5;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	LAPTM; lysosomal-associated transmembrane protein; K12387	lysosomal protein transmembrane 4 alpha [Source:HGNC Symbol%3BAcc:HGNC:6924]
ENSG00000164054	90.39	87.18	84.97	91.59	85.41	91.22	-0.0191346218679103	6.93349429765249	0.768267917631388	0.94364829423693	3:48467797-48504826:-	SHISA5	17;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	SCOTIN; scotin; K10135	shisa family member 5 [Source:HGNC Symbol%3BAcc:HGNC:30376]
ENSG00000144218	4.41	3.44	4.83	4.68	3.54	5.00	-0.0409583746720148	4.18845687859267	0.768351165430072	0.943657169930096	2:99545418-100142739:-	AFF3	10;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016604,cellular_component nuclear body;GO:0034612,biological_process response to tumor necrosis factor;GO:0035116,biological_process embryonic hindlimb morphogenesis	NA	AF4/FMR2 family member 3 [Source:HGNC Symbol%3BAcc:HGNC:6473]
ENSG00000166529	8.85	8.94	10.28	8.66	9.45	10.94	-0.03668808433634	3.8093783068838	0.768556830460758	0.943681990326324	7:100049773-100065038:+	ZSCAN21	13;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 21 [Source:HGNC Symbol%3BAcc:HGNC:13104]
ENSG00000117758	19.21	18.86	18.30	17.86	17.50	20.30	0.027561596592101	4.08041854365796	0.768579617998702	0.943681990326324	1:27773182-27824452:+	STX12	26;GO:0000045,biological_process autophagosome assembly;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0000407,cellular_component pre-autophagosomal structure;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006906,biological_process vesicle fusion;GO:0010008,cellular_component endosome membrane;GO:0012505,cellular_component endomembrane system;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031083,cellular_component BLOC-1 complex;GO:0031201,cellular_component SNARE complex;GO:0031982,cellular_component vesicle;GO:0033344,biological_process cholesterol efflux;GO:0045121,cellular_component membrane raft;GO:0045335,cellular_component phagocytic vesicle;GO:0048278,biological_process vesicle docking;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome	STX12, STX13; syntaxin 12/13; K13813	syntaxin 12 [Source:HGNC Symbol%3BAcc:HGNC:11430]
ENSG00000123570	2.69	1.43	2.93	1.86	3.90	2.10	-0.105951246234043	0.740717956253889	0.768599445919531	0.943681990326324	X:103822321-103832228:-	RAB9B	16;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043312,biological_process neutrophil degranulation;GO:0045335,cellular_component phagocytic vesicle	RAB9B; Ras-related protein Rab-9B; K07900	RAB9B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:14090]
ENSG00000136045	32.71	34.77	34.08	33.16	35.07	32.66	0.0199024927812829	5.6951142545647	0.768694026817544	0.943704772513716	12:107685731-107713167:+	PWP1	8;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0033140,biological_process negative regulation of peptidyl-serine phosphorylation of STAT protein;GO:0034773,biological_process histone H4-K20 trimethylation;GO:1990889,molecular_function H4K20me3 modified histone binding;GO:2000738,biological_process positive regulation of stem cell differentiation	NA	PWP1 homolog%2C endonuclein [Source:HGNC Symbol%3BAcc:HGNC:17015]
ENSG00000169241	48.87	39.82	52.57	44.01	43.23	52.32	0.0344960902081149	4.98780070434914	0.768807171367021	0.943750338031926	1:155135343-155138857:+	SLC50A1	15;GO:0000139,cellular_component Golgi membrane;GO:0005634,cellular_component nucleus;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0008645,biological_process hexose transport;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034219,biological_process carbohydrate transmembrane transport;GO:0042946,biological_process glucoside transport;GO:0042947,molecular_function glucoside transmembrane transporter activity;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0051119,molecular_function sugar transmembrane transporter activity	NA	solute carrier family 50 member 1 [Source:HGNC Symbol%3BAcc:HGNC:30657]
ENSG00000184060	2.98	3.21	2.79	3.48	2.29	3.76	-0.0837038234529864	1.90155894141883	0.768950260222111	0.943832649079112	17:30906343-30959322:+	ADAP2	14;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005740,cellular_component mitochondrial envelope;GO:0005886,cellular_component plasma membrane;GO:0007507,biological_process heart development;GO:0016020,cellular_component membrane;GO:0030674,molecular_function protein binding, bridging;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0043533,molecular_function inositol 1,3,4,5 tetrakisphosphate binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	NA	ArfGAP with dual PH domains 2 [Source:HGNC Symbol%3BAcc:HGNC:16487]
ENSG00000070087	345.79	328.10	339.94	356.25	300.33	350.55	0.0215665179605171	7.82882820893561	0.769044491745167	0.943854980821907	3:149964903-150050788:-	PFN2	23;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0030833,biological_process regulation of actin filament polymerization;GO:0030837,biological_process negative regulation of actin filament polymerization;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0032781,biological_process positive regulation of ATPase activity;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0043195,cellular_component terminal bouton;GO:0050821,biological_process protein stabilization;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0070062,cellular_component extracellular exosome;GO:1900028,biological_process negative regulation of ruffle assembly;GO:2000300,biological_process regulation of synaptic vesicle exocytosis	PFN; profilin; K05759	profilin 2 [Source:HGNC Symbol%3BAcc:HGNC:8882]
ENSG00000165804	2.86	3.17	2.41	2.55	3.08	2.58	0.0453650462672842	2.71302228429684	0.769237792033262	0.943998884083923	14:21090045-21104722:-	ZNF219	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001505,biological_process regulation of neurotransmitter levels;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004969,molecular_function histamine receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016021,cellular_component integral component of membrane;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 219 [Source:HGNC Symbol%3BAcc:HGNC:13011]
ENSG00000162396	8.18	7.85	7.28	8.25	8.09	6.56	0.0393392712629438	3.47473832975248	0.769336062740442	0.944026151324348	1:54756897-54764514:-	PARS2	11;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004827,molecular_function proline-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006433,biological_process prolyl-tRNA aminoacylation;GO:0016874,molecular_function ligase activity	PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]; K01881	prolyl-tRNA synthetase 2%2C mitochondrial (putative) [Source:HGNC Symbol%3BAcc:HGNC:30563]
ENSG00000173757	12.59	11.98	12.41	12.59	11.72	12.39	0.0245434200787112	4.86700101078395	0.769520237161817	0.944158812285227	17:42199167-42276707:-	STAT5B	75;GO:0000255,biological_process allantoin metabolic process;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001553,biological_process luteinization;GO:0001779,biological_process natural killer cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006101,biological_process citrate metabolic process;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006105,biological_process succinate metabolic process;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006549,biological_process isoleucine metabolic process;GO:0006573,biological_process valine metabolic process;GO:0006600,biological_process creatine metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0007165,biological_process signal transduction;GO:0007259,biological_process JAK-STAT cascade;GO:0007548,biological_process sex differentiation;GO:0007565,biological_process female pregnancy;GO:0007595,biological_process lactation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019218,biological_process regulation of steroid metabolic process;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019530,biological_process taurine metabolic process;GO:0019915,biological_process lipid storage;GO:0030155,biological_process regulation of cell adhesion;GO:0030856,biological_process regulation of epithelial cell differentiation;GO:0032355,biological_process response to estradiol;GO:0032819,biological_process positive regulation of natural killer cell proliferation;GO:0032825,biological_process positive regulation of natural killer cell differentiation;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033077,biological_process T cell differentiation in thymus;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0040014,biological_process regulation of multicellular organism growth;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0042448,biological_process progesterone metabolic process;GO:0043029,biological_process T cell homeostasis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045086,biological_process positive regulation of interleukin-2 biosynthetic process;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0045588,biological_process positive regulation of gamma-delta T cell differentiation;GO:0045621,biological_process positive regulation of lymphocyte differentiation;GO:0045647,biological_process negative regulation of erythrocyte differentiation;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045954,biological_process positive regulation of natural killer cell mediated cytotoxicity;GO:0046449,biological_process creatinine metabolic process;GO:0046543,biological_process development of secondary female sexual characteristics;GO:0046544,biological_process development of secondary male sexual characteristics;GO:0046983,molecular_function protein dimerization activity;GO:0048541,biological_process Peyer's patch development;GO:0050729,biological_process positive regulation of inflammatory response;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway;GO:0070669,biological_process response to interleukin-2;GO:0070670,biological_process response to interleukin-4;GO:0070672,biological_process response to interleukin-15;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0097531,biological_process mast cell migration	STAT5B; signal transducer and activator of transcription 5B; K11224	signal transducer and activator of transcription 5B [Source:HGNC Symbol%3BAcc:HGNC:11367]
ENSG00000205155	29.04	30.37	25.62	28.34	33.14	26.45	-0.0395837617769853	3.63999472345419	0.769667817586904	0.944246552649362	19:35745113-35747519:+	PSENEN	21;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007219,biological_process Notch signaling pathway;GO:0007220,biological_process Notch receptor processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0032580,cellular_component Golgi cisterna membrane;GO:0034205,biological_process beta-amyloid formation;GO:0042982,biological_process amyloid precursor protein metabolic process;GO:0042987,biological_process amyloid precursor protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0070765,cellular_component gamma-secretase complex	PSENEN, PEN2; presenilin enhancer 2; K06170	presenilin enhancer gamma-secretase subunit [Source:HGNC Symbol%3BAcc:HGNC:30100]
ENSG00000171262	19.74	26.98	19.88	22.16	21.79	21.47	0.0288946157328158	4.93795986040883	0.770001608786306	0.944436898708237	15:38454126-38487710:+	FAM98B	13;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006479,biological_process protein methylation;GO:0008276,molecular_function protein methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0072669,cellular_component tRNA-splicing ligase complex	NA	family with sequence similarity 98 member B [Source:HGNC Symbol%3BAcc:HGNC:26773]
ENSG00000172167	17.06	16.52	19.15	17.10	17.10	19.92	-0.0242225834170754	5.61383620294048	0.770072121542614	0.944436898708237	8:120445399-120542133:+	MTBP	8;GO:0000776,cellular_component kinetochore;GO:0000785,cellular_component chromatin;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007089,biological_process traversing start control point of mitotic cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0034501,biological_process protein localization to kinetochore;GO:0045839,biological_process negative regulation of mitotic nuclear division	NA	MDM2 binding protein [Source:HGNC Symbol%3BAcc:HGNC:7417]
ENSG00000274523	24.10	27.22	27.57	24.97	24.91	28.24	0.022579893688732	5.35571797383373	0.770088279269254	0.944436898708237	7:75027121-75074228:-	RCC1L	4;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process	NA	RCC1 like [Source:HGNC Symbol%3BAcc:HGNC:14948]
ENSG00000073605	14.83	11.72	15.27	13.98	10.88	16.17	0.0443034206588563	4.1279704451909	0.770127309169804	0.944436898708237	17:39904594-39919854:-	GSDMB	5;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane	NA	gasdermin B [Source:HGNC Symbol%3BAcc:HGNC:23690]
ENSG00000175471	7.59	7.87	7.23	7.21	8.07	7.98	-0.0282484808593589	4.59956977852688	0.770463528964984	0.944755881165894	5:94703740-95284575:-	MCTP1	5;GO:0005509,molecular_function calcium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019722,biological_process calcium-mediated signaling	NA	multiple C2 and transmembrane domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26183]
ENSG00000198265	7.83	8.06	7.96	8.29	8.54	7.58	-0.0214695612142043	5.61384822201885	0.770592806045978	0.944821068890629	17:67070437-67245989:-	HELZ	9;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	helicase with zinc finger [Source:HGNC Symbol%3BAcc:HGNC:16878]
ENSG00000115355	15.29	15.01	14.52	15.28	14.32	14.98	0.0191007607468574	6.51968021083188	0.770778960548174	0.944955974052789	2:55287841-55419921:-	CCDC88A	37;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006260,biological_process DNA replication;GO:0006275,biological_process regulation of DNA replication;GO:0007399,biological_process nervous system development;GO:0008017,molecular_function microtubule binding;GO:0010975,biological_process regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0030027,cellular_component lamellipodium;GO:0030030,biological_process cell projection organization;GO:0030032,biological_process lamellipodium assembly;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031252,cellular_component cell leading edge;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031929,biological_process TOR signaling;GO:0032148,biological_process activation of protein kinase B activity;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036064,cellular_component ciliary basal body;GO:0042127,biological_process regulation of cell proliferation;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043422,molecular_function protein kinase B binding;GO:0045724,biological_process positive regulation of cilium assembly;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0061024,biological_process membrane organization;GO:1903566,biological_process positive regulation of protein localization to cilium	NA	coiled-coil domain containing 88A [Source:HGNC Symbol%3BAcc:HGNC:25523]
ENSG00000183655	2.20	2.06	2.50	2.63	1.80	2.07	0.0740982426269806	2.02333417303127	0.771040547539463	0.945046845643698	15:85759322-85795030:-	KLHL25	8;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification	NA	kelch like family member 25 [Source:HGNC Symbol%3BAcc:HGNC:25732]
ENSG00000140043	8.38	6.63	7.83	7.47	7.49	8.88	-0.0404678913646335	3.06967457565302	0.771087595796981	0.945046845643698	14:73851843-73886827:+	PTGR2	7;GO:0005737,cellular_component cytoplasm;GO:0006693,biological_process prostaglandin metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0036132,molecular_function 13-prostaglandin reductase activity;GO:0047522,molecular_function 15-oxoprostaglandin 13-oxidase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	prostaglandin reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:20149]
ENSG00000186889	7.85	6.60	8.30	7.06	6.89	10.06	-0.0609650723429524	2.26885859374968	0.771344819964277	0.945046845643698	2:62500220-62511894:-	TMEM17	12;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0042995,cellular_component cell projection;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:1905515,biological_process non-motile cilium assembly	NA	transmembrane protein 17 [Source:HGNC Symbol%3BAcc:HGNC:26623]
ENSG00000076043	94.26	101.81	91.63	103.29	94.62	96.05	-0.0219474802922246	6.15789257512216	0.771395340407442	0.945046845643698	11:114439385-114450279:+	REXO2	18;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005925,cellular_component focal adhesion;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0009117,biological_process nucleotide metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	orn, REX2, REXO2; oligoribonuclease [EC:3.1.-.-]; K13288	RNA exonuclease 2 [Source:HGNC Symbol%3BAcc:HGNC:17851]
ENSG00000163539	6.75	7.45	7.46	6.05	8.10	7.24	0.0286805166165938	5.16780359794683	0.771446425664517	0.945046845643698	3:33496244-33718356:-	CLASP2	52;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0002162,molecular_function dystroglycan binding;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005828,cellular_component kinetochore microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006903,biological_process vesicle targeting;GO:0007020,biological_process microtubule nucleation;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007030,biological_process Golgi organization;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0008017,molecular_function microtubule binding;GO:0010458,biological_process exit from mitosis;GO:0010470,biological_process regulation of gastrulation;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0016020,cellular_component membrane;GO:0031023,biological_process microtubule organizing center organization;GO:0031110,biological_process regulation of microtubule polymerization or depolymerization;GO:0031252,cellular_component cell leading edge;GO:0032587,cellular_component ruffle membrane;GO:0032886,biological_process regulation of microtubule-based process;GO:0034453,biological_process microtubule anchoring;GO:0042995,cellular_component cell projection;GO:0045180,cellular_component basal cortex;GO:0045921,biological_process positive regulation of exocytosis;GO:0051010,molecular_function microtubule plus-end binding;GO:0051301,biological_process cell division;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0072686,cellular_component mitotic spindle;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0090091,biological_process positive regulation of extracellular matrix disassembly;GO:1903690,biological_process negative regulation of wound healing, spreading of epidermal cells;GO:1904261,biological_process positive regulation of basement membrane assembly involved in embryonic body morphogenesis	NA	cytoplasmic linker associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17078]
ENSG00000101294	163.04	170.30	159.13	159.50	171.90	158.60	0.0184888865718825	7.79847081416729	0.771533515887942	0.945046845643698	20:31514427-31577923:+	HM13	23;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033619,biological_process membrane protein proteolysis;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042500,molecular_function aspartic endopeptidase activity, intramembrane cleaving;GO:0042803,molecular_function protein homodimerization activity;GO:0051289,biological_process protein homotetramerization;GO:0071458,cellular_component integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:1904211,biological_process membrane protein proteolysis involved in retrograde protein transport, ER to cytosol	NA	histocompatibility minor 13 [Source:HGNC Symbol%3BAcc:HGNC:16435]
ENSG00000118640	100.15	111.24	96.89	96.49	105.79	103.12	0.020631316584231	5.47252806534233	0.77154529660804	0.945046845643698	2:85561561-85582031:+	VAMP8	46;GO:0000149,molecular_function SNARE binding;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006906,biological_process vesicle fusion;GO:0006914,biological_process autophagy;GO:0008021,cellular_component synaptic vesicle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016240,biological_process autophagosome docking;GO:0019869,molecular_function chloride channel inhibitor activity;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0046718,biological_process viral entry into host cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0065009,biological_process regulation of molecular function;GO:0070062,cellular_component extracellular exosome;GO:0070254,biological_process mucus secretion;GO:0070821,cellular_component tertiary granule membrane;GO:0097352,biological_process autophagosome maturation;GO:0098594,cellular_component mucin granule;GO:1903076,biological_process regulation of protein localization to plasma membrane;GO:1903531,biological_process negative regulation of secretion by cell;GO:1903595,biological_process positive regulation of histamine secretion by mast cell	VAMP8; vesicle-associated membrane protein 8; K08512	vesicle associated membrane protein 8 [Source:HGNC Symbol%3BAcc:HGNC:12647]
ENSG00000177600	1069.01	985.85	977.08	1056.89	971.00	1069.65	-0.0189205992365495	8.46290922298268	0.771723367497258	0.945046845643698	11:809646-812880:+	RPLP2	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006414,biological_process translational elongation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070062,cellular_component extracellular exosome	RP-LP2, RPLP2; large subunit ribosomal protein LP2; K02943	ribosomal protein lateral stalk subunit P2 [Source:HGNC Symbol%3BAcc:HGNC:10377]
ENSG00000144224	63.04	58.64	60.51	57.77	60.61	62.93	0.0197078030771395	6.69241206422781	0.771736416540855	0.945046845643698	2:135741618-135785055:+	UBXN4	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process	NA	UBX domain protein 4 [Source:HGNC Symbol%3BAcc:HGNC:14860]
ENSG00000005882	10.87	11.74	10.61	10.98	10.50	12.79	-0.0399625115038877	3.79540631040871	0.771795717235561	0.945046845643698	17:50094736-50112152:+	PDK2	26;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004740,molecular_function pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0005967,cellular_component mitochondrial pyruvate dehydrogenase complex;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006468,biological_process protein phosphorylation;GO:0006885,biological_process regulation of pH;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010565,biological_process regulation of cellular ketone metabolic process;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031670,biological_process cellular response to nutrient;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0042593,biological_process glucose homeostasis;GO:0042803,molecular_function protein homodimerization activity;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator	NA	pyruvate dehydrogenase kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:8810]
ENSG00000181619	1.14	1.23	1.04	1.77	0.97	0.95	-0.103878340741728	0.926453154682997	0.771821171190886	0.945046845643698	14:59429021-59465342:-	GPR135	7;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 135 [Source:HGNC Symbol%3BAcc:HGNC:19991]
ENSG00000072832	24.50	26.83	23.22	23.69	25.99	24.23	0.0205889280985801	5.72306833031548	0.771836817922615	0.945046845643698	4:5748083-5893058:-	CRMP1	17;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0030496,cellular_component midbody;GO:0031005,molecular_function filamin binding;GO:0048666,biological_process neuron development;GO:1904530,biological_process negative regulation of actin filament binding	NA	collapsin response mediator protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2365]
ENSG00000108528	44.16	39.87	39.54	43.00	40.74	38.97	0.0247702791756445	5.28013696676978	0.771842819716088	0.945046845643698	17:4937129-4940251:-	SLC25A11	12;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006094,biological_process gluconeogenesis;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0015367,molecular_function oxoglutarate:malate antiporter activity;GO:0015742,biological_process alpha-ketoglutarate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 25 member 11 [Source:HGNC Symbol%3BAcc:HGNC:10981]
ENSG00000179698	0.36	0.25	0.52	0.35	0.37	0.36	0.115625060898752	0.990894617250732	0.772171683601348	0.945170210208315	8:144107725-144118315:+	WDR97	1;GO:0005737,cellular_component cytoplasm	NA	WD repeat domain 97 [Source:HGNC Symbol%3BAcc:HGNC:26959]
ENSG00000171443	10.26	10.38	11.99	11.72	9.58	10.65	0.0440310648124578	3.11904036305653	0.772246596623572	0.945170210208315	19:55600021-55603138:+	ZNF524	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 524 [Source:HGNC Symbol%3BAcc:HGNC:28322]
ENSG00000108774	13.33	15.84	16.26	15.25	16.76	14.89	-0.0381599992172097	3.75545025986178	0.772262430248196	0.945170210208315	17:42124975-42155044:-	RAB5C	22;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005811,cellular_component lipid particle;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030100,biological_process regulation of endocytosis;GO:0030139,cellular_component endocytic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0042470,cellular_component melanosome;GO:0043312,biological_process neutrophil degranulation;GO:0048227,biological_process plasma membrane to endosome transport;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	RAB5C; Ras-related protein Rab-5C; K07889	RAB5C%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9785]
ENSG00000169371	34.07	30.73	30.32	34.97	29.73	29.54	0.0275939960872063	5.13447332288687	0.772276723132577	0.945170210208315	15:75598082-75626469:-	SNUPN	13;GO:0000339,molecular_function RNA cap binding;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0051170,biological_process nuclear import;GO:0061015,biological_process snRNA import into nucleus;GO:0070062,cellular_component extracellular exosome	SNUPN, RNUT1; snurportin-1; K13151	snurportin 1 [Source:HGNC Symbol%3BAcc:HGNC:14245]
ENSG00000233024	0.89	0.90	0.87	0.70	1.01	1.16	-0.110490961429067	0.411257846845923	0.772378762732601	0.945170210208315	16:18358085-18379331:-	AC126755.2	1;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex-interacting protein family member A5 isoform 2  [Source:RefSeq peptide%3BAcc:NP_001338129]
ENSG00000105376	5.50	4.00	5.07	5.21	4.84	5.10	-0.0317048494117107	3.80443742620857	0.772400436022971	0.945170210208315	19:10289980-10296778:+	ICAM5	11;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006909,biological_process phagocytosis;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0050776,biological_process regulation of immune response	NA	intercellular adhesion molecule 5 [Source:HGNC Symbol%3BAcc:HGNC:5348]
ENSG00000185022	9.62	6.99	8.08	8.83	5.24	9.58	0.0812049597187973	2.05296557657454	0.772477481274791	0.945171313461211	22:38200766-38216511:+	MAFF	16;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007567,biological_process parturition;GO:0007596,biological_process blood coagulation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045604,biological_process regulation of epidermal cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	MAF bZIP transcription factor F [Source:HGNC Symbol%3BAcc:HGNC:6780]
ENSG00000132780	69.21	74.71	66.96	68.12	71.51	70.12	0.018318204345766	7.47676001464374	0.772714056982121	0.945360062074275	1:45583845-45618904:+	NASP	19;GO:0000790,cellular_component nuclear chromatin;GO:0001824,biological_process blastocyst development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0008584,biological_process male gonad development;GO:0015031,biological_process protein transport;GO:0033574,biological_process response to testosterone;GO:0042393,molecular_function histone binding;GO:0043234,cellular_component protein complex;GO:0043486,biological_process histone exchange;GO:0051879,molecular_function Hsp90 protein binding	NA	nuclear autoantigenic sperm protein [Source:HGNC Symbol%3BAcc:HGNC:7644]
ENSG00000140632	38.53	40.75	39.28	40.62	41.38	39.07	-0.0199403670598462	6.07088949142921	0.772836547473473	0.945360062074275	16:4803202-4847342:-	GLYR1	14;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0004616,molecular_function phosphogluconate dehydrogenase (decarboxylating) activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0016491,molecular_function oxidoreductase activity;GO:0016607,cellular_component nuclear speck;GO:0035064,molecular_function methylated histone binding;GO:0042393,molecular_function histone binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process	NA	glyoxylate reductase 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:24434]
ENSG00000124217	6.65	9.07	7.52	6.89	8.74	6.98	0.0414336219952799	3.41027576551804	0.772860219925058	0.945360062074275	20:50958825-50963931:+	MOCS3	24;GO:0000166,molecular_function nucleotide binding;GO:0002098,biological_process tRNA wobble uridine modification;GO:0002143,biological_process tRNA wobble position uridine thiolation;GO:0003824,molecular_function catalytic activity;GO:0004792,molecular_function thiosulfate sulfurtransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006777,biological_process Mo-molybdopterin cofactor biosynthetic process;GO:0008033,biological_process tRNA processing;GO:0008152,biological_process metabolic process;GO:0008641,molecular_function small protein activating enzyme activity;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0016783,molecular_function sulfurtransferase activity;GO:0018192,biological_process enzyme active site formation via cysteine modification to L-cysteine persulfide;GO:0032324,biological_process molybdopterin cofactor biosynthetic process;GO:0032447,biological_process protein urmylation;GO:0034227,biological_process tRNA thio-modification;GO:0042292,molecular_function URM1 activating enzyme activity;GO:0046872,molecular_function metal ion binding;GO:0061604,molecular_function molybdopterin-synthase sulfurtransferase activity;GO:0061605,molecular_function molybdopterin-synthase adenylyltransferase activity	MOCS3, UBA4; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]; K11996	molybdenum cofactor synthesis 3 [Source:HGNC Symbol%3BAcc:HGNC:15765]
ENSG00000174500	2.42	2.13	1.77	2.05	1.43	2.29	0.135591833213263	0.41131883082402	0.773218439237637	0.945668761990586	3:112120840-112133305:-	GCSAM	10;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0045159,molecular_function myosin II binding;GO:0050855,biological_process regulation of B cell receptor signaling pathway;GO:2000401,biological_process regulation of lymphocyte migration;GO:2000402,biological_process negative regulation of lymphocyte migration	NA	germinal center associated signaling and motility [Source:HGNC Symbol%3BAcc:HGNC:20253]
ENSG00000065000	45.55	45.96	47.08	48.21	46.82	46.40	-0.0174036538559304	7.45554506258552	0.773297757860936	0.945668761990586	19:2100987-2164465:-	AP3D1	32;GO:0000139,cellular_component Golgi membrane;GO:0005215,molecular_function transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006726,biological_process eye pigment biosynthetic process;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008089,biological_process anterograde axonal transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016182,biological_process synaptic vesicle budding from endosome;GO:0016192,biological_process vesicle-mediated transport;GO:0019882,biological_process antigen processing and presentation;GO:0030117,cellular_component membrane coat;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030424,cellular_component axon;GO:0032438,biological_process melanosome organization;GO:0033365,biological_process protein localization to organelle;GO:0035646,biological_process endosome to melanosome transport;GO:0043195,cellular_component terminal bouton;GO:0048007,biological_process antigen processing and presentation, exogenous lipid antigen via MHC class Ib;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0048499,biological_process synaptic vesicle membrane organization;GO:0051138,biological_process positive regulation of NK T cell differentiation;GO:0061088,biological_process regulation of sequestering of zinc ion;GO:0072657,biological_process protein localization to membrane;GO:0098830,cellular_component presynaptic endosome;GO:0098943,biological_process neurotransmitter receptor transport, postsynaptic endosome to lysosome;GO:1904115,cellular_component axon cytoplasm	AP3D; AP-3 complex subunit delta; K12396	adaptor related protein complex 3 delta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:568]
ENSG00000177374	1.22	1.17	1.71	1.26	1.31	1.38	0.0775487511227184	1.63918261441144	0.773375272896163	0.945668761990586	17:2054153-2063241:+	HIC1	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016055,biological_process Wnt signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0042826,molecular_function histone deacetylase binding;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	HIC ZBTB transcriptional repressor 1 [Source:HGNC Symbol%3BAcc:HGNC:4909]
ENSG00000105486	13.47	15.48	10.45	12.92	13.43	14.23	-0.0360656668421784	5.24836941483703	0.773487126825254	0.945668761990586	19:48115444-48170603:-	LIG1	26;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003909,molecular_function DNA ligase activity;GO:0003910,molecular_function DNA ligase (ATP) activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006260,biological_process DNA replication;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006284,biological_process base-excision repair;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016874,molecular_function ligase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0051301,biological_process cell division;GO:0071897,biological_process DNA biosynthetic process;GO:1903461,biological_process Okazaki fragment processing involved in mitotic DNA replication	LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]; K10747	DNA ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:6598]
ENSG00000181350	1.64	0.65	1.50	1.09	0.88	2.25	-0.115109923324622	0.64927949737141	0.773568207893195	0.945668761990586	17:16441576-16492153:-	LRRC75A	NA	NA	leucine rich repeat containing 75A [Source:HGNC Symbol%3BAcc:HGNC:32403]
ENSG00000129315	9.04	10.40	8.58	8.55	8.98	10.03	0.02610531239506	4.34887832622444	0.773569693809104	0.945668761990586	12:48688457-48716998:-	CCNT1	30;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0017069,molecular_function snRNA binding;GO:0019901,molecular_function protein kinase binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050434,biological_process positive regulation of viral transcription;GO:0051301,biological_process cell division;GO:0070063,molecular_function RNA polymerase binding;GO:0097322,molecular_function 7SK snRNA binding;GO:1900364,biological_process negative regulation of mRNA polyadenylation;GO:1901409,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain	CCNT; cyclin T; K15188	cyclin T1 [Source:HGNC Symbol%3BAcc:HGNC:1599]
ENSG00000166225	5.65	5.77	5.75	4.81	6.07	6.97	-0.0478677452342279	3.18020296296915	0.773718135568623	0.945757086835384	12:69470348-69579789:+	FRS2	45;GO:0000165,biological_process MAPK cascade;GO:0000186,biological_process activation of MAPKK activity;GO:0000187,biological_process activation of MAPK activity;GO:0001702,biological_process gastrulation with mouth forming second;GO:0001759,biological_process organ induction;GO:0002088,biological_process lens development in camera-type eye;GO:0003281,biological_process ventricular septum development;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005104,molecular_function fibroblast growth factor receptor binding;GO:0005158,molecular_function insulin receptor binding;GO:0005168,molecular_function neurotrophin TRKA receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007185,biological_process transmembrane receptor protein tyrosine phosphatase signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007405,biological_process neuroblast proliferation;GO:0007411,biological_process axon guidance;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0008595,biological_process anterior/posterior axis specification, embryo;GO:0012505,cellular_component endomembrane system;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0019211,molecular_function phosphatase activator activity;GO:0030900,biological_process forebrain development;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046619,biological_process optic placode formation involved in camera-type eye formation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050678,biological_process regulation of epithelial cell proliferation;GO:0060527,biological_process prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0070307,biological_process lens fiber cell development;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:2000726,biological_process negative regulation of cardiac muscle cell differentiation	FRS2; fibroblast growth factor receptor substrate 2; K12461	fibroblast growth factor receptor substrate 2 [Source:HGNC Symbol%3BAcc:HGNC:16971]
ENSG00000138867	38.23	37.88	36.05	36.59	37.39	37.39	0.0210107023567782	5.12299737238706	0.773865790328396	0.945844432389364	22:24540422-24555935:-	GUCD1	1;GO:0005515,molecular_function protein binding	NA	guanylyl cyclase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14237]
ENSG00000075240	16.36	15.38	18.68	18.27	15.36	18.26	-0.0268231602785754	4.99153671121044	0.774324302842688	0.94601024841561	22:46576011-46679790:+	GRAMD4	5;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane	NA	GRAM domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:29113]
ENSG00000059145	4.34	4.26	4.97	4.75	4.59	4.72	-0.0356737269091625	3.51490723320592	0.774324603134605	0.94601024841561	16:1363204-1414751:-	UNKL	9;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	unkempt family like zinc finger [Source:HGNC Symbol%3BAcc:HGNC:14184]
ENSG00000095139	110.31	110.00	106.62	110.53	109.99	112.98	-0.0171831400040189	7.63867398386505	0.774326911764162	0.94601024841561	11:118572389-118603033:+	ARCN1	23;GO:0000139,cellular_component Golgi membrane;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0008344,biological_process adult locomotory behavior;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0021691,biological_process cerebellar Purkinje cell layer maturation;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030137,cellular_component COPI-coated vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043473,biological_process pigmentation;GO:0048193,biological_process Golgi vesicle transport	NA	archain 1 [Source:HGNC Symbol%3BAcc:HGNC:649]
ENSG00000158201	13.92	15.16	13.40	15.49	14.26	13.86	-0.0316680307419944	4.25757400276583	0.77435498300153	0.94601024841561	18:21650896-21704805:-	ABHD3	13;GO:0004623,molecular_function phospholipase A2 activity;GO:0005575,cellular_component cellular_component;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046470,biological_process phosphatidylcholine metabolic process;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0052739,molecular_function phosphatidylserine 1-acylhydrolase activity;GO:0052740,molecular_function 1-acyl-2-lysophosphatidylserine acylhydrolase activity	NA	abhydrolase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:18718]
ENSG00000196588	9.73	9.49	10.30	9.78	10.45	9.05	0.0265095100891162	4.94361819251424	0.774400138492181	0.94601024841561	22:40410280-40636702:-	MKL1	27;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001764,biological_process neuron migration;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003779,molecular_function actin binding;GO:0003785,molecular_function actin monomer binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0010735,biological_process positive regulation of transcription via serum response element binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030900,biological_process forebrain development;GO:0031175,biological_process neuron projection development;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043522,molecular_function leucine zipper domain binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051145,biological_process smooth muscle cell differentiation;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	NA	megakaryoblastic leukemia (translocation) 1 [Source:HGNC Symbol%3BAcc:HGNC:14334]
ENSG00000114391	914.39	851.76	846.97	883.01	882.39	900.55	-0.0169254585161305	8.86116934527367	0.774599691817068	0.94601024841561	3:101681090-101686782:-	RPL24	24;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0010458,biological_process exit from mitosis;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0021554,biological_process optic nerve development;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031290,biological_process retinal ganglion cell axon guidance;GO:0045296,molecular_function cadherin binding;GO:0060041,biological_process retina development in camera-type eye;GO:0070062,cellular_component extracellular exosome;GO:1902626,biological_process assembly of large subunit precursor of preribosome	RP-L24e, RPL24; large subunit ribosomal protein L24e; K02896	ribosomal protein L24 [Source:HGNC Symbol%3BAcc:HGNC:10325]
ENSG00000067992	8.16	9.20	9.63	8.89	9.07	8.58	0.0334115557049119	3.49280123106034	0.774638070554531	0.94601024841561	X:24465220-24539837:+	PDK3	22;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004740,molecular_function pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035357,biological_process peroxisome proliferator activated receptor signaling pathway;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071398,biological_process cellular response to fatty acid;GO:0097411,biological_process hypoxia-inducible factor-1alpha signaling pathway;GO:2000377,biological_process regulation of reactive oxygen species metabolic process	NA	pyruvate dehydrogenase kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:8811]
ENSG00000206127	1.00	0.85	1.12	0.94	0.92	1.37	-0.0978295856119614	1.09709071251863	0.774762823173008	0.94601024841561	15:32445105-32455634:-	GOLGA8O	2;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus	NA	golgin A8 family member O [Source:HGNC Symbol%3BAcc:HGNC:44406]
ENSG00000116455	19.75	24.21	17.88	20.66	23.57	19.47	-0.0383039016657137	4.47806166054867	0.774776320231291	0.94601024841561	1:111439889-111449376:-	WDR77	17;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008327,molecular_function methyl-CpG binding;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0034709,cellular_component methylosome;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0060528,biological_process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060770,biological_process negative regulation of epithelial cell proliferation involved in prostate gland development	NA	WD repeat domain 77 [Source:HGNC Symbol%3BAcc:HGNC:29652]
ENSG00000147133	24.88	23.76	26.39	24.48	24.47	25.74	0.0191862764770721	7.19617118700768	0.774791629410359	0.94601024841561	X:71366238-71532374:+	TAF1	67;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000790,cellular_component nuclear chromatin;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001075,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly;GO:0001129,molecular_function RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly;GO:0002039,molecular_function p53 binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0010767,biological_process regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0017025,molecular_function TBP-class protein binding;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030901,biological_process midbrain development;GO:0032092,biological_process positive regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034644,biological_process cellular response to UV;GO:0036369,biological_process transcription factor catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0050821,biological_process protein stabilization;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:0060260,biological_process regulation of transcription initiation from RNA polymerase II promoter;GO:0060261,biological_process positive regulation of transcription initiation from RNA polymerase II promoter;GO:0061628,molecular_function H3K27me3 modified histone binding;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0071318,biological_process cellular response to ATP;GO:0071339,cellular_component MLL1 complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902806,biological_process regulation of cell cycle G1/S phase transition;GO:1903026,biological_process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:1905524,biological_process negative regulation of protein autoubiquitination;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000825,biological_process positive regulation of androgen receptor activity	TAF1; transcription initiation factor TFIID subunit 1 [EC:2.3.1.48 2.7.11.1]; K03125	TATA-box binding protein associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11535]
ENSG00000120438	172.76	181.57	161.84	164.11	176.73	172.75	0.0184688089561981	8.18924427690418	0.774839780523766	0.94601024841561	6:159778497-159789749:-	TCP1	39;GO:0000166,molecular_function nucleotide binding;GO:0000242,cellular_component pericentriolar material;GO:0000792,cellular_component heterochromatin;GO:0001669,cellular_component acrosomal vesicle;GO:0002199,cellular_component zona pellucida receptor complex;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005720,cellular_component nuclear heterochromatin;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007021,biological_process tubulin complex assembly;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043209,cellular_component myelin sheath;GO:0044053,biological_process translocation of peptides or proteins into host cell cytoplasm;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044297,cellular_component cell body;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051973,biological_process positive regulation of telomerase activity;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0090666,biological_process scaRNA localization to Cajal body;GO:1901998,biological_process toxin transport;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body;GO:2000109,biological_process regulation of macrophage apoptotic process	NA	t-complex 1 [Source:HGNC Symbol%3BAcc:HGNC:11655]
ENSG00000173531	5.71	5.84	8.19	6.71	6.20	7.63	-0.0423572776816874	3.88941088848798	0.775001054829387	0.946111509398545	3:49683946-49689501:-	MST1	16;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005773,cellular_component vacuole;GO:0006508,biological_process proteolysis;GO:0007283,biological_process spermatogenesis;GO:0007566,biological_process embryo implantation;GO:0010628,biological_process positive regulation of gene expression;GO:0010758,biological_process regulation of macrophage chemotaxis;GO:0019899,molecular_function enzyme binding;GO:0030317,biological_process sperm motility;GO:0030879,biological_process mammary gland development;GO:0033601,biological_process positive regulation of mammary gland epithelial cell proliferation;GO:0046425,biological_process regulation of JAK-STAT cascade;GO:0060763,biological_process mammary duct terminal end bud growth;GO:0071456,biological_process cellular response to hypoxia;GO:1904036,biological_process negative regulation of epithelial cell apoptotic process	NA	macrophage stimulating 1 [Source:HGNC Symbol%3BAcc:HGNC:7380]
ENSG00000134248	223.41	223.39	208.11	219.59	220.51	211.59	0.0183867173378921	6.90922279644668	0.775075158227166	0.946111509398545	1:110401248-110407942:-	LAMTOR5	19;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0007050,biological_process cell cycle arrest;GO:0008361,biological_process regulation of cell size;GO:0009615,biological_process response to virus;GO:0016241,biological_process regulation of macroautophagy;GO:0019079,biological_process viral genome replication;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032947,molecular_function protein complex scaffold;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061462,biological_process protein localization to lysosome;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071986,cellular_component Ragulator complex	LAMTOR5, HBXIP; ragulator complex protein LAMTOR5; K16344	late endosomal/lysosomal adaptor%2C MAPK and MTOR activator 5 [Source:HGNC Symbol%3BAcc:HGNC:17955]
ENSG00000103507	64.35	59.92	64.23	60.73	63.00	63.97	0.0195655746834536	6.48937725231654	0.775318293608817	0.946267806982466	16:31106106-31112791:+	BCKDK	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005947,cellular_component mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0006468,biological_process protein phosphorylation;GO:0009063,biological_process cellular amino acid catabolic process;GO:0009083,biological_process branched-chain amino acid catabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016772,molecular_function transferase activity, transferring phosphorus-containing groups;GO:0047323,molecular_function [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	NA	branched chain ketoacid dehydrogenase kinase [Source:HGNC Symbol%3BAcc:HGNC:16902]
ENSG00000053371	47.28	53.95	48.11	47.34	50.63	50.14	0.0191268863986217	5.74167441283527	0.775355664611187	0.946267806982466	1:19303964-19312146:-	AKR7A2	16;GO:0004032,molecular_function alditol:NADP+ 1-oxidoreductase activity;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019119,molecular_function phenanthrene-9,10-epoxide hydrolase activity;GO:0044597,biological_process daunorubicin metabolic process;GO:0044598,biological_process doxorubicin metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	AKR7; aflatoxin B1 aldehyde reductase; K15303	aldo-keto reductase family 7 member A2 [Source:HGNC Symbol%3BAcc:HGNC:389]
ENSG00000181826	10.70	10.11	9.31	10.49	10.15	10.50	-0.0362011423229138	3.32264250086945	0.775674558754728	0.946563930183095	4:37590799-37686376:-	RELL1	4;GO:0005886,cellular_component plasma membrane;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	RELT like 1 [Source:HGNC Symbol%3BAcc:HGNC:27379]
ENSG00000137941	2.95	3.33	3.48	3.05	3.53	3.54	-0.0431242251878756	3.19934872596356	0.775764029838631	0.946580055282309	1:83865027-83999150:-	TTLL7	19;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0006464,biological_process cellular protein modification process;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0016874,molecular_function ligase activity;GO:0018095,biological_process protein polyglutamylation;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0043014,molecular_function alpha-tubulin binding;GO:0043204,cellular_component perikaryon;GO:0048487,molecular_function beta-tubulin binding;GO:0070740,molecular_function tubulin-glutamic acid ligase activity	NA	tubulin tyrosine ligase like 7 [Source:HGNC Symbol%3BAcc:HGNC:26242]
ENSG00000100425	13.33	13.32	14.07	14.13	13.50	12.85	0.0213632050912047	5.59854131168637	0.775890461660442	0.946641271927567	22:49773282-49827512:-	BRD1	11;GO:0005634,cellular_component nucleus;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0030425,cellular_component dendrite;GO:0035902,biological_process response to immobilization stress;GO:0042393,molecular_function histone binding;GO:0043204,cellular_component perikaryon;GO:0043966,biological_process histone H3 acetylation;GO:0046872,molecular_function metal ion binding;GO:0051602,biological_process response to electrical stimulus;GO:0070776,cellular_component MOZ/MORF histone acetyltransferase complex	NA	bromodomain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:1102]
ENSG00000126767	20.41	17.86	21.15	20.00	17.90	20.97	0.0301666804885061	4.67488828769215	0.776116603207934	0.946824117505659	X:47635520-47650604:-	ELK1	29;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0009416,biological_process response to light stimulus;GO:0030154,biological_process cell differentiation;GO:0030425,cellular_component dendrite;GO:0043025,cellular_component neuronal cell body;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043679,cellular_component axon terminus;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0071394,biological_process cellular response to testosterone stimulus;GO:0071396,biological_process cellular response to lipid;GO:0071480,biological_process cellular response to gamma radiation;GO:0071774,biological_process response to fibroblast growth factor;GO:1901216,biological_process positive regulation of neuron death	ELK1; ETS domain-containing protein Elk-1; K04375	ELK1%2C ETS transcription factor [Source:HGNC Symbol%3BAcc:HGNC:3321]
ENSG00000277462	3.09	4.75	3.91	4.04	4.61	2.53	0.072636381659666	2.18834060152866	0.776365793041433	0.946955378429326	1:247036783-247078755:-	ZNF670	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 670 [Source:HGNC Symbol%3BAcc:HGNC:28167]
ENSG00000134955	13.96	10.13	15.41	16.51	9.08	15.83	-0.0529548354926287	4.3866497008454	0.776376773243797	0.946955378429326	11:125063066-125090312:+	SLC37A2	14;GO:0005215,molecular_function transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015297,molecular_function antiporter activity;GO:0015760,biological_process glucose-6-phosphate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0061513,molecular_function glucose 6-phosphate:inorganic phosphate antiporter activity;GO:0070062,cellular_component extracellular exosome	NA	solute carrier family 37 member 2 [Source:HGNC Symbol%3BAcc:HGNC:20644]
ENSG00000181588	24.61	21.55	20.55	19.98	24.39	24.19	-0.0260877917611406	5.50806006345327	0.776535924958169	0.947014997871672	19:1554668-1568058:-	MEX3D	9;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0010609,biological_process mRNA localization resulting in posttranscriptional regulation of gene expression;GO:0017091,molecular_function AU-rich element binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0061157,biological_process mRNA destabilization	NA	mex-3 RNA binding family member D [Source:HGNC Symbol%3BAcc:HGNC:16734]
ENSG00000181191	33.08	35.59	33.96	33.44	35.30	33.29	0.0182334828374479	6.08012058182392	0.776645210357924	0.947014997871672	X:69160850-69165793:-	PJA1	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030163,biological_process protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	praja ring finger ubiquitin ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:16648]
ENSG00000185507	3.67	2.83	3.82	4.47	2.61	3.82	-0.0589678280585543	2.59884800342171	0.776678665117586	0.947014997871672	11:612552-615999:-	IRF7	43;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000975,molecular_function regulatory region DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002376,biological_process immune system process;GO:0002819,biological_process regulation of adaptive immune response;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009615,biological_process response to virus;GO:0010008,cellular_component endosome membrane;GO:0016032,biological_process viral process;GO:0016064,biological_process immunoglobulin mediated immune response;GO:0019043,biological_process establishment of viral latency;GO:0032479,biological_process regulation of type I interferon production;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032607,biological_process interferon-alpha production;GO:0032608,biological_process interferon-beta production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0034124,biological_process regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0034127,biological_process regulation of MyD88-independent toll-like receptor signaling pathway;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0039530,biological_process MDA-5 signaling pathway;GO:0045087,biological_process innate immune response;GO:0045351,biological_process type I interferon biosynthetic process;GO:0045655,biological_process regulation of monocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050776,biological_process regulation of immune response;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060337,biological_process type I interferon signaling pathway;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway;GO:2000110,biological_process negative regulation of macrophage apoptotic process	IRF7; interferon regulatory factor 7; K09447	interferon regulatory factor 7 [Source:HGNC Symbol%3BAcc:HGNC:6122]
ENSG00000188869	0.38	0.35	0.40	0.27	0.30	0.47	0.134812896000799	0.438276768708502	0.776730821987552	0.947014997871672	15:81331216-81374213:-	TMC3	4;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane channel like 3 [Source:HGNC Symbol%3BAcc:HGNC:22995]
ENSG00000179029	17.41	19.00	17.85	20.54	16.74	18.87	-0.0434052467724149	3.23307553562728	0.77699344150943	0.94722752441943	17:8173236-8176399:-	TMEM107	13;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021532,biological_process neural tube patterning;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0042733,biological_process embryonic digit morphogenesis;GO:0060271,biological_process cilium morphogenesis;GO:1904491,biological_process protein localization to ciliary transition zone;GO:1905515,biological_process non-motile cilium assembly	NA	transmembrane protein 107 [Source:HGNC Symbol%3BAcc:HGNC:28128]
ENSG00000145736	7.55	7.02	5.77	7.40	6.50	7.23	-0.0453499561626288	3.10853760436526	0.777145859588448	0.94722752441943	5:71032669-71067689:-	GTF2H2	42;GO:0000438,cellular_component core TFIIH complex portion of holo TFIIH complex;GO:0000439,cellular_component core TFIIH complex;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0002031,biological_process G-protein coupled receptor internalization;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005675,cellular_component holo TFIIH complex;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006412,biological_process translation;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0008270,molecular_function zinc ion binding;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0009411,biological_process response to UV;GO:0016607,cellular_component nuclear speck;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0070911,biological_process global genome nucleotide-excision repair	TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2; K03142	general transcription factor IIH subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:4656]
ENSG00000144837	4.13	5.25	5.01	4.01	6.41	4.64	-0.0595595611238916	2.8613957452615	0.777209227971383	0.94722752441943	3:119597841-119629811:+	PLA1A	12;GO:0002080,cellular_component acrosomal membrane;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006629,biological_process lipid metabolic process;GO:0006658,biological_process phosphatidylserine metabolic process;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0052739,molecular_function phosphatidylserine 1-acylhydrolase activity;GO:0070062,cellular_component extracellular exosome	PLA1A; phospholipase A1 member A [EC:3.1.1.-]; K13618	phospholipase A1 member A [Source:HGNC Symbol%3BAcc:HGNC:17661]
ENSG00000163013	5.46	4.91	4.65	5.25	4.77	4.80	0.0361105810083553	3.72484687149292	0.77724766224811	0.94722752441943	2:73254681-73284431:-	FBXO41	4;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	F-box protein 41 [Source:HGNC Symbol%3BAcc:HGNC:29409]
ENSG00000160410	29.56	30.30	28.37	28.08	31.22	30.83	-0.0206251329012085	6.04013423530871	0.777334682429017	0.94722752441943	19:40576850-40591399:+	SHKBP1	4;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0051260,biological_process protein homooligomerization	NA	SH3KBP1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:19214]
ENSG00000135482	2.50	3.60	3.90	3.11	4.19	3.24	-0.0718757117642124	2.19830532574636	0.777362989709235	0.94722752441943	12:56118158-56127514:+	ZC3H10	3;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCCH-type containing 10 [Source:HGNC Symbol%3BAcc:HGNC:25893]
ENSG00000137821	7.45	5.44	7.15	7.96	4.76	8.27	-0.051103504271314	4.05409792766983	0.777762452104553	0.947401737948917	15:70853238-71053657:+	LRRC49	3;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule	NA	leucine rich repeat containing 49 [Source:HGNC Symbol%3BAcc:HGNC:25965]
ENSG00000139350	13.69	13.99	14.12	14.85	13.95	14.01	-0.0231674238156933	4.8421939094167	0.777965087608419	0.947401737948917	12:96907222-96953777:+	NEDD1	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000242,cellular_component pericentriolar material;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0036064,cellular_component ciliary basal body;GO:0045177,cellular_component apical part of cell;GO:0051301,biological_process cell division;GO:0071539,biological_process protein localization to centrosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	neural precursor cell expressed%2C developmentally down-regulated 1 [Source:HGNC Symbol%3BAcc:HGNC:7723]
ENSG00000205138	9.01	8.03	8.75	8.68	11.21	7.54	-0.065716442186325	1.68586701669436	0.778025832905787	0.947401737948917	19:35995198-35996315:+	SDHAF1	4;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0034553,biological_process mitochondrial respiratory chain complex II assembly	NA	succinate dehydrogenase complex assembly factor 1 [Source:HGNC Symbol%3BAcc:HGNC:33867]
ENSG00000183111	6.59	4.25	6.80	6.66	4.87	5.69	0.057961335228225	3.58728993310262	0.778064158347634	0.947401737948917	5:149551946-149634968:+	ARHGEF37	6;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	Rho guanine nucleotide exchange factor 37 [Source:HGNC Symbol%3BAcc:HGNC:34430]
ENSG00000183067	1.04	0.16	1.21	0.61	0.68	0.92	0.186395141384993	0.171267727960211	0.778101774156065	0.947401737948917	21:39745406-39802096:+	IGSF5	6;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction	JAM4, JCAM; junctional adhesion molecule 4; K06786	immunoglobulin superfamily member 5 [Source:HGNC Symbol%3BAcc:HGNC:5952]
ENSG00000260371	4.38	4.29	7.08	7.84	3.08	6.16	-0.0987265225137767	1.45110159398957	0.77823043802328	0.947401737948917	16:69335090-69356306:-	AC026464.3	2;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0017119,cellular_component Golgi transport complex	NA	NA
ENSG00000110057	19.62	23.93	21.87	20.56	22.86	21.31	0.0219203418769789	5.33850693311826	0.778303308105568	0.947401737948917	11:67991103-68004982:-	UNC93B1	20;GO:0000139,cellular_component Golgi membrane;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006886,biological_process intracellular protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032009,cellular_component early phagosome;GO:0034138,biological_process toll-like receptor 3 signaling pathway;GO:0034154,biological_process toll-like receptor 7 signaling pathway;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0035325,molecular_function Toll-like receptor binding;GO:0045087,biological_process innate immune response;GO:0045335,cellular_component phagocytic vesicle;GO:0051607,biological_process defense response to virus	NA	unc-93 homolog B1 (C. elegans) [Source:HGNC Symbol%3BAcc:HGNC:13481]
ENSG00000130699	4.15	4.23	4.72	4.15	4.00	4.77	0.0322211052610019	3.86501122527402	0.778350338915157	0.947401737948917	20:61953468-62065810:-	TAF4	28;GO:0000790,cellular_component nuclear chromatin;GO:0001075,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly;GO:0001541,biological_process ovarian follicle development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0016032,biological_process viral process;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0033276,cellular_component transcription factor TFTC complex;GO:0043234,cellular_component protein complex;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:0071339,cellular_component MLL1 complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF4; transcription initiation factor TFIID subunit 4; K03129	TATA-box binding protein associated factor 4 [Source:HGNC Symbol%3BAcc:HGNC:11537]
ENSG00000258947	1.02	1.18	1.10	1.19	1.29	1.05	-0.0933612822514903	1.23684798855151	0.778377210841485	0.947401737948917	16:89921391-89938761:+	TUBB3	15;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0007411,biological_process axon guidance;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030425,cellular_component dendrite;GO:0070062,cellular_component extracellular exosome	TUBB; tubulin beta; K07375	tubulin beta 3 class III [Source:HGNC Symbol%3BAcc:HGNC:20772]
ENSG00000139133	4.11	4.15	3.76	4.09	4.36	3.20	0.0581442301846591	2.5281059510191	0.778382579124806	0.947401737948917	12:34022280-34029694:+	ALG10	9;GO:0004583,molecular_function dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	ALG10; alpha-1,2-glucosyltransferase [EC:2.4.1.256]; K03850	ALG10%2C alpha-1%2C2-glucosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:23162]
ENSG00000174744	25.37	28.51	26.36	26.50	27.48	28.14	-0.0279006375034055	4.69471783570361	0.778394364501101	0.947401737948917	11:66337332-66345125:-	BRMS1	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0009987,biological_process cellular process;GO:0016575,biological_process histone deacetylation;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0042826,molecular_function histone deacetylase binding;GO:0042981,biological_process regulation of apoptotic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051059,molecular_function NF-kappaB binding;GO:0070822,cellular_component Sin3-type complex;GO:0090312,biological_process positive regulation of protein deacetylation;GO:2000210,biological_process positive regulation of anoikis	NA	breast cancer metastasis suppressor 1 [Source:HGNC Symbol%3BAcc:HGNC:17262]
ENSG00000172766	5.32	4.94	5.43	4.84	5.04	5.59	0.034597853601024	3.79125071793645	0.778439128816669	0.947401737948917	13:41311204-41377030:+	NAA16	15;GO:0004596,molecular_function peptide alpha-N-acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006474,biological_process N-terminal protein amino acid acetylation;GO:0016407,molecular_function acetyltransferase activity;GO:0017196,biological_process N-terminal peptidyl-methionine acetylation;GO:0031415,cellular_component NatA complex;GO:0043022,molecular_function ribosome binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0050821,biological_process protein stabilization;GO:0070062,cellular_component extracellular exosome	NA	N(alpha)-acetyltransferase 16%2C NatA auxiliary subunit [Source:HGNC Symbol%3BAcc:HGNC:26164]
ENSG00000185420	15.93	18.17	17.68	17.18	16.46	17.54	0.0228492462304758	4.48691431224437	0.778647503091682	0.947401737948917	1:245749341-246507312:-	SMYD3	21;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993,molecular_function RNA polymerase II core binding;GO:0001162,molecular_function RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0008168,molecular_function methyltransferase activity;GO:0014904,biological_process myotube cell development;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034968,biological_process histone lysine methylation;GO:0045184,biological_process establishment of protein localization;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0071549,biological_process cellular response to dexamethasone stimulus	SMYD; [histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357]; K11426	SET and MYND domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:15513]
ENSG00000135502	1.22	1.43	1.79	1.50	1.42	1.35	0.0691202444477991	1.70315613736246	0.778746549446832	0.947401737948917	12:57619526-57626151:+	SLC26A10	19;GO:0005254,molecular_function chloride channel activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008271,molecular_function secondary active sulfate transmembrane transporter activity;GO:0008272,biological_process sulfate transport;GO:0015106,molecular_function bicarbonate transmembrane transporter activity;GO:0015116,molecular_function sulfate transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019531,molecular_function oxalate transmembrane transporter activity;GO:0019532,biological_process oxalate transport;GO:0042391,biological_process regulation of membrane potential;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:1902358,biological_process sulfate transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 26 member 10 [Source:HGNC Symbol%3BAcc:HGNC:14470]
ENSG00000082068	24.34	23.48	25.15	25.25	25.58	23.82	-0.0185970652738124	5.64889366631359	0.778790336948007	0.947401737948917	5:37379211-37753435:+	WDR70	1;GO:0019899,molecular_function enzyme binding	NA	WD repeat domain 70 [Source:HGNC Symbol%3BAcc:HGNC:25495]
ENSG00000139722	15.30	10.15	13.65	13.49	13.90	13.33	-0.0320934811671627	3.70265434864396	0.778829482601681	0.947401737948917	12:122865327-122896444:-	VPS37B	22;GO:0000813,cellular_component ESCRT I complex;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0030496,cellular_component midbody;GO:0031902,cellular_component late endosome membrane;GO:0036258,biological_process multivesicular body assembly;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0043657,cellular_component host cell;GO:0048306,molecular_function calcium-dependent protein binding;GO:0070062,cellular_component extracellular exosome;GO:0075733,biological_process intracellular transport of virus;GO:1902188,biological_process positive regulation of viral release from host cell;GO:1903774,biological_process positive regulation of viral budding via host ESCRT complex	VPS37; ESCRT-I complex subunit VPS37; K12185	VPS37B%2C ESCRT-I subunit [Source:HGNC Symbol%3BAcc:HGNC:25754]
ENSG00000182197	97.70	105.36	95.88	98.35	101.08	98.16	0.0174189577346108	7.83426240894176	0.778878076444066	0.947401737948917	8:117794489-118111853:-	EXT1	32;GO:0000139,cellular_component Golgi membrane;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006486,biological_process protein glycosylation;GO:0007165,biological_process signal transduction;GO:0007369,biological_process gastrulation;GO:0007411,biological_process axon guidance;GO:0007420,biological_process brain development;GO:0007492,biological_process endoderm development;GO:0007498,biological_process mesoderm development;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0015014,biological_process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0015020,molecular_function glucuronosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0021772,biological_process olfactory bulb development;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0033692,biological_process cellular polysaccharide biosynthetic process;GO:0042328,molecular_function heparan sulfate N-acetylglucosaminyltransferase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0050508,molecular_function glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509,molecular_function N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity;GO:0072498,biological_process embryonic skeletal joint development	EXT1; glucuronyl/N-acetylglucosaminyl transferase EXT1 [EC:2.4.1.224 2.4.1.225]; K02366	exostosin glycosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:3512]
ENSG00000033178	34.80	31.17	34.56	34.02	32.04	36.80	-0.0198127142334855	6.7790823559131	0.778981155388161	0.947401737948917	4:67612651-67701179:-	UBA6	19;GO:0000166,molecular_function nucleotide binding;GO:0004839,molecular_function ubiquitin activating enzyme activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007612,biological_process learning;GO:0007626,biological_process locomotory behavior;GO:0008641,molecular_function small protein activating enzyme activity;GO:0016567,biological_process protein ubiquitination;GO:0016874,molecular_function ligase activity;GO:0019780,molecular_function FAT10 activating enzyme activity;GO:0021764,biological_process amygdala development;GO:0021766,biological_process hippocampus development;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0060996,biological_process dendritic spine development	UBE1L2, UBA6; ubiquitin-activating enzyme E1-like protein 2 [EC:6.2.1.45]; K10699	ubiquitin like modifier activating enzyme 6 [Source:HGNC Symbol%3BAcc:HGNC:25581]
ENSG00000133606	63.06	62.44	64.98	62.64	63.23	68.67	-0.0184999391614305	6.7793860222172	0.779111738756069	0.947401737948917	7:140453039-140479569:-	MKRN1	10;GO:0000209,biological_process protein polyubiquitination;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	makorin ring finger protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7112]
ENSG00000134245	1.41	1.69	1.87	1.50	1.34	1.90	0.0724240454667667	1.17296432985622	0.779201718887269	0.947401737948917	1:112466540-112530165:+	WNT2B	23;GO:0002062,biological_process chondrocyte differentiation;GO:0002088,biological_process lens development in camera-type eye;GO:0005102,molecular_function receptor binding;GO:0005109,molecular_function frizzled binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0008584,biological_process male gonad development;GO:0009267,biological_process cellular response to starvation;GO:0016055,biological_process Wnt signaling pathway;GO:0021871,biological_process forebrain regionalization;GO:0030182,biological_process neuron differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045165,biological_process cell fate commitment;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060492,biological_process lung induction;GO:0060638,biological_process mesenchymal-epithelial cell signaling;GO:0061072,biological_process iris morphogenesis;GO:0061303,biological_process cornea development in camera-type eye;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway	WNT2; wingless-type MMTV integration site family, member 2; K00182	Wnt family member 2B [Source:HGNC Symbol%3BAcc:HGNC:12781]
ENSG00000106459	9.79	6.96	8.55	8.51	9.49	8.31	-0.0316090682669084	3.77596222691099	0.77927932671524	0.947401737948917	7:129611713-129757082:+	NRF1	19;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007005,biological_process mitochondrion organization;GO:0016491,molecular_function oxidoreductase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NRF1; nuclear respiratory factor 1; K11831	nuclear respiratory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:7996]
ENSG00000101181	13.22	9.96	14.26	14.81	13.45	10.68	-0.0346030733773322	3.97621819233614	0.779330501361906	0.947401737948917	20:62183028-62203568:+	MTG2	14;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0005761,cellular_component mitochondrial ribosome;GO:0006417,biological_process regulation of translation;GO:0016020,cellular_component membrane;GO:0042254,biological_process ribosome biogenesis;GO:0044065,biological_process regulation of respiratory system process;GO:0046872,molecular_function metal ion binding;GO:0070129,biological_process regulation of mitochondrial translation	NA	mitochondrial ribosome associated GTPase 2 [Source:HGNC Symbol%3BAcc:HGNC:16239]
ENSG00000131845	4.60	4.78	4.69	4.63	5.23	4.71	-0.0395969515011831	3.35947447419175	0.779341387580809	0.947401737948917	19:57351306-57359898:+	ZNF304	22;GO:0001525,biological_process angiogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0016569,biological_process covalent chromatin modification;GO:0030335,biological_process positive regulation of cell migration;GO:0035562,biological_process negative regulation of chromatin binding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0090309,biological_process positive regulation of methylation-dependent chromatin silencing;GO:1900114,biological_process positive regulation of histone H3-K9 trimethylation;GO:1902466,biological_process positive regulation of histone H3-K27 trimethylation;GO:1990841,molecular_function promoter-specific chromatin binding;GO:2000811,biological_process negative regulation of anoikis	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 304 [Source:HGNC Symbol%3BAcc:HGNC:13505]
ENSG00000159128	51.73	44.34	46.10	50.54	42.50	48.08	0.0248223886875408	5.77057711631917	0.779393353266888	0.947401737948917	21:33402895-33479348:+	IFNGR2	18;GO:0000139,cellular_component Golgi membrane;GO:0004906,molecular_function interferon-gamma receptor activity;GO:0004920,molecular_function interleukin-10 receptor activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0051607,biological_process defense response to virus;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060334,biological_process regulation of interferon-gamma-mediated signaling pathway	IFNGR2; interferon gamma receptor 2; K05133	interferon gamma receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:5440]
ENSG00000111364	13.91	13.09	13.52	15.77	13.68	12.26	-0.0272306995489536	4.64926226249931	0.779414045592068	0.947401737948917	12:123602076-123620941:+	DDX55	14;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity	NA	DEAD-box helicase 55 [Source:HGNC Symbol%3BAcc:HGNC:20085]
ENSG00000169621	2.80	2.92	2.06	2.58	2.09	2.84	0.0502838589033634	2.83755561458602	0.779508188995308	0.947423396651205	2:68467560-68655862:+	APLF	19;GO:0000012,biological_process single strand break repair;GO:0000166,molecular_function nucleotide binding;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0016829,molecular_function lyase activity;GO:0035861,cellular_component site of double-strand break;GO:0045191,biological_process regulation of isotype switching;GO:0046872,molecular_function metal ion binding;GO:0051106,biological_process positive regulation of DNA ligation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	aprataxin and PNKP like factor [Source:HGNC Symbol%3BAcc:HGNC:28724]
ENSG00000105700	77.08	74.54	75.03	78.35	73.69	79.58	-0.019155048385023	5.67871971723732	0.779735530742514	0.947606926092307	19:18557761-18569387:+	KXD1	8;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031083,cellular_component BLOC-1 complex;GO:0032418,biological_process lysosome localization;GO:0099078,cellular_component BORC complex	NA	KxDL motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28420]
ENSG00000166582	8.15	10.11	8.93	8.82	7.11	10.40	0.0456673044812839	2.91734849711762	0.779836511049542	0.947636868493192	17:16342533-16353656:-	CENPV	22;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001667,biological_process ameboidal-type cell migration;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0008152,biological_process metabolic process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016846,molecular_function carbon-sulfur lyase activity;GO:0031508,biological_process pericentric heterochromatin assembly;GO:0032467,biological_process positive regulation of cytokinesis;GO:0033044,biological_process regulation of chromosome organization;GO:0034508,biological_process centromere complex assembly;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division	NA	centromere protein V [Source:HGNC Symbol%3BAcc:HGNC:29920]
ENSG00000165494	21.04	19.65	21.11	21.11	19.75	20.68	0.0191621584845058	6.7078611853275	0.779985402607111	0.947706224989272	11:83156987-83187451:+	PCF11	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000993,molecular_function RNA polymerase II core binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005849,cellular_component mRNA cleavage factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006379,biological_process mRNA cleavage;GO:0006397,biological_process mRNA processing;GO:0031124,biological_process mRNA 3'-end processing	PCF11; pre-mRNA cleavage complex 2 protein Pcf11; K14400	PCF11 cleavage and polyadenylation factor subunit [Source:HGNC Symbol%3BAcc:HGNC:30097]
ENSG00000077254	37.44	37.82	36.29	36.74	37.21	39.93	-0.0187786512235077	6.73788153762662	0.780046282181213	0.947706224989272	1:77695986-77759852:-	USP33	38;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006897,biological_process endocytosis;GO:0007411,biological_process axon guidance;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009267,biological_process cellular response to starvation;GO:0010506,biological_process regulation of autophagy;GO:0016477,biological_process cell migration;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0017160,molecular_function Ral GTPase binding;GO:0030891,cellular_component VCB complex;GO:0032091,biological_process negative regulation of protein binding;GO:0032092,biological_process positive regulation of protein binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0044297,cellular_component cell body;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050821,biological_process protein stabilization;GO:0051298,biological_process centrosome duplication;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0071108,biological_process protein K48-linked deubiquitination	NA	ubiquitin specific peptidase 33 [Source:HGNC Symbol%3BAcc:HGNC:20059]
ENSG00000090857	9.49	10.78	10.70	10.50	9.72	10.43	0.0223267971148066	4.81670493518948	0.780311905454192	0.947936159953306	16:70113625-70162537:+	PDPR	7;GO:0004741,molecular_function [pyruvate dehydrogenase (lipoamide)] phosphatase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016311,biological_process dephosphorylation;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	pyruvate dehydrogenase phosphatase regulatory subunit [Source:HGNC Symbol%3BAcc:HGNC:30264]
ENSG00000196449	9.70	8.45	8.44	10.20	7.25	10.25	-0.0449132696293997	2.9554214951616	0.780423554712234	0.947979017970737	1:37802943-37808185:-	YRDC	9;GO:0000049,molecular_function tRNA binding;GO:0002949,biological_process tRNA threonylcarbamoyladenosine modification;GO:0003725,molecular_function double-stranded RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006450,biological_process regulation of translational fidelity;GO:0016020,cellular_component membrane;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0051051,biological_process negative regulation of transport	NA	yrdC N6-threonylcarbamoyltransferase domain containing [Source:HGNC Symbol%3BAcc:HGNC:28905]
ENSG00000132837	0.66	0.50	0.69	1.01	0.45	0.55	-0.0933462465126782	0.915860122380809	0.780589458492382	0.948039436319661	5:78997605-79236038:-	DMGDH	10;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006579,biological_process amino-acid betaine catabolic process;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019695,biological_process choline metabolic process;GO:0042426,biological_process choline catabolic process;GO:0047865,molecular_function dimethylglycine dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process	DMGDH; dimethylglycine dehydrogenase [EC:1.5.8.4]; K00315	dimethylglycine dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:24475]
ENSG00000137996	46.55	46.19	55.82	48.88	47.65	50.98	0.0237769246676105	5.81728626446225	0.780683269988627	0.948039436319661	1:100266206-100292769:+	RTCA	9;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0003963,molecular_function RNA-3'-phosphate cyclase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006396,biological_process RNA processing;GO:0016874,molecular_function ligase activity	NA	RNA 3'-terminal phosphate cyclase [Source:HGNC Symbol%3BAcc:HGNC:17981]
ENSG00000169031	0.22	0.25	0.26	0.28	0.27	0.25	-0.120964552513249	0.530166790666298	0.780702418275966	0.948039436319661	2:227164564-227314792:+	COL4A3	27;GO:0005178,molecular_function integrin binding;GO:0005198,molecular_function structural molecule activity;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005587,cellular_component collagen type IV trimer;GO:0005604,cellular_component basement membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007155,biological_process cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007605,biological_process sensory perception of sound;GO:0008015,biological_process blood circulation;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0032836,biological_process glomerular basement membrane development;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0072577,biological_process endothelial cell apoptotic process	COL4A; collagen, type IV, alpha; K06237	collagen type IV alpha 3 chain [Source:HGNC Symbol%3BAcc:HGNC:2204]
ENSG00000166483	22.11	23.99	20.54	23.15	22.51	22.43	-0.0237179762918066	5.51306954408027	0.780864964840582	0.948083004563084	11:9573680-9593457:+	WEE1	26;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000278,biological_process mitotic cell cycle;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030010,biological_process establishment of cell polarity;GO:0046872,molecular_function metal ion binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	WEE1; wee1-like protein kinase [EC:2.7.11.1]; K06632	WEE1 G2 checkpoint kinase [Source:HGNC Symbol%3BAcc:HGNC:12761]
ENSG00000204444	2.93	3.51	3.53	2.87	3.63	4.16	-0.0960029743848015	1.2049873802332	0.780891052819864	0.948083004563084	6:31652415-31658210:+	APOM	25;GO:0001523,biological_process retinoid metabolic process;GO:0005319,molecular_function lipid transporter activity;GO:0005543,molecular_function phospholipid binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0009749,biological_process response to glucose;GO:0016209,molecular_function antioxidant activity;GO:0033344,biological_process cholesterol efflux;GO:0034361,cellular_component very-low-density lipoprotein particle;GO:0034362,cellular_component low-density lipoprotein particle;GO:0034364,cellular_component high-density lipoprotein particle;GO:0034365,cellular_component discoidal high-density lipoprotein particle;GO:0034366,cellular_component spherical high-density lipoprotein particle;GO:0034375,biological_process high-density lipoprotein particle remodeling;GO:0034380,biological_process high-density lipoprotein particle assembly;GO:0034384,biological_process high-density lipoprotein particle clearance;GO:0034445,biological_process negative regulation of plasma lipoprotein particle oxidation;GO:0042157,biological_process lipoprotein metabolic process;GO:0042632,biological_process cholesterol homeostasis;GO:0043691,biological_process reverse cholesterol transport;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	NA	apolipoprotein M [Source:HGNC Symbol%3BAcc:HGNC:13916]
ENSG00000143257	1.73	1.70	1.70	1.89	1.47	1.57	0.0718935814307878	1.26720600441272	0.78111258181622	0.94825921546061	1:161229665-161238302:-	NR1I3	26;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004882,molecular_function androgen receptor activity;GO:0004887,molecular_function thyroid hormone receptor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	nuclear receptor subfamily 1 group I member 3 [Source:HGNC Symbol%3BAcc:HGNC:7969]
ENSG00000169221	13.55	14.23	13.48	12.79	14.61	13.52	0.0216738588153529	5.05926709958253	0.781209182494483	0.948283745580287	16:30357101-30370264:-	TBC1D10B	13;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043087,biological_process regulation of GTPase activity;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 10B [Source:HGNC Symbol%3BAcc:HGNC:24510]
ENSG00000163069	58.13	56.52	60.00	59.21	58.57	56.16	0.0195103989017428	5.89815539698907	0.781360637958204	0.948290606359436	4:52020705-52038482:-	SGCB	15;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007517,biological_process muscle organ development;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016011,cellular_component dystroglycan complex;GO:0016012,cellular_component sarcoglycan complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042383,cellular_component sarcolemma;GO:0048747,biological_process muscle fiber development;GO:0055013,biological_process cardiac muscle cell development;GO:0061024,biological_process membrane organization;GO:0097084,biological_process vascular smooth muscle cell development	SGCB; beta-sarcoglycan; K12566	sarcoglycan beta [Source:HGNC Symbol%3BAcc:HGNC:10806]
ENSG00000099889	1.63	2.14	2.03	1.80	2.22	1.98	-0.051616898603708	2.54718203619701	0.781367624413463	0.948290606359436	22:19969895-20016808:-	ARVCF	9;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NA	armadillo repeat gene deleted in velocardiofacial syndrome [Source:HGNC Symbol%3BAcc:HGNC:728]
ENSG00000110955	339.51	361.73	323.90	333.60	357.23	329.57	0.0181485007506844	9.08086526792459	0.781828903125402	0.948540913603821	12:56638174-56646068:-	ATP5B	44;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001649,biological_process osteoblast differentiation;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005754,cellular_component mitochondrial proton-transporting ATP synthase, catalytic core;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006629,biological_process lipid metabolic process;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006933,biological_process negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0007005,biological_process mitochondrion organization;GO:0009986,cellular_component cell surface;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0031012,cellular_component extracellular matrix;GO:0031966,cellular_component mitochondrial membrane;GO:0042288,molecular_function MHC class I protein binding;GO:0042407,biological_process cristae formation;GO:0042645,cellular_component mitochondrial nucleoid;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0043209,cellular_component myelin sheath;GO:0043532,molecular_function angiostatin binding;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045259,cellular_component proton-transporting ATP synthase complex;GO:0045261,cellular_component proton-transporting ATP synthase complex, catalytic core F(1);GO:0046034,biological_process ATP metabolic process;GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0051453,biological_process regulation of intracellular pH;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF1B, ATP5B, ATP2; F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]; K02133	ATP synthase%2C H+ transporting%2C mitochondrial F1 complex%2C beta polypeptide [Source:HGNC Symbol%3BAcc:HGNC:830]
ENSG00000168724	41.97	35.62	38.50	38.00	36.91	40.57	0.0223354658988116	6.06531801884774	0.781848223578019	0.948540913603821	5:34929592-34958964:+	DNAJC21	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005840,cellular_component ribosome;GO:0006457,biological_process protein folding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	DnaJ heat shock protein family (Hsp40) member C21 [Source:HGNC Symbol%3BAcc:HGNC:27030]
ENSG00000075415	280.61	306.98	275.20	289.10	301.60	289.87	-0.0181439400700881	8.72595046081786	0.781882278992263	0.948540913603821	12:98593590-98606379:+	SLC25A3	14;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0015293,molecular_function symporter activity;GO:0015320,molecular_function phosphate ion carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032403,molecular_function protein complex binding;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0043209,cellular_component myelin sheath;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome	NA	solute carrier family 25 member 3 [Source:HGNC Symbol%3BAcc:HGNC:10989]
ENSG00000114757	4.37	3.42	4.34	4.23	3.72	4.69	-0.0379132671299309	3.10797164309737	0.781949678232092	0.948540913603821	3:179794957-180037053:-	PEX5L	10;GO:0000268,molecular_function peroxisome targeting sequence binding;GO:0005052,molecular_function peroxisome matrix targeting signal-1 binding;GO:0005737,cellular_component cytoplasm;GO:0005778,cellular_component peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016560,biological_process protein import into peroxisome matrix, docking;GO:0031267,molecular_function small GTPase binding;GO:0043235,cellular_component receptor complex;GO:0043949,biological_process regulation of cAMP-mediated signaling	NA	peroxisomal biogenesis factor 5 like [Source:HGNC Symbol%3BAcc:HGNC:30024]
ENSG00000132356	65.17	63.03	69.37	64.66	65.50	66.63	0.0185815667533743	6.86864962826371	0.781955946903078	0.948540913603821	5:40759378-40798374:-	PRKAA1	86;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001666,biological_process response to hypoxia;GO:0003682,molecular_function chromatin binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004679,molecular_function AMP-activated protein kinase activity;GO:0004691,molecular_function cAMP-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006006,biological_process glucose metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006914,biological_process autophagy;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008610,biological_process lipid biosynthetic process;GO:0009411,biological_process response to UV;GO:0009631,biological_process cold acclimation;GO:0010332,biological_process response to gamma radiation;GO:0010508,biological_process positive regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0014823,biological_process response to activity;GO:0016055,biological_process Wnt signaling pathway;GO:0016126,biological_process sterol biosynthetic process;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019395,biological_process fatty acid oxidation;GO:0019900,molecular_function kinase binding;GO:0031000,biological_process response to caffeine;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0031669,biological_process cellular response to nutrient levels;GO:0032007,biological_process negative regulation of TOR signaling;GO:0033135,biological_process regulation of peptidyl-serine phosphorylation;GO:0035174,molecular_function histone serine kinase activity;GO:0035404,biological_process histone-serine phosphorylation;GO:0042149,biological_process cellular response to glucose starvation;GO:0042542,biological_process response to hydrogen peroxide;GO:0042593,biological_process glucose homeostasis;GO:0042752,biological_process regulation of circadian rhythm;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0045542,biological_process positive regulation of cholesterol biosynthetic process;GO:0045821,biological_process positive regulation of glycolytic process;GO:0046318,biological_process negative regulation of glucosylceramide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0047322,molecular_function [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity;GO:0048511,biological_process rhythmic process;GO:0048643,biological_process positive regulation of skeletal muscle tissue development;GO:0050321,molecular_function tau-protein kinase activity;GO:0050405,molecular_function [acetyl-CoA carboxylase] kinase activity;GO:0050995,biological_process negative regulation of lipid catabolic process;GO:0051291,biological_process protein heterooligomerization;GO:0055089,biological_process fatty acid homeostasis;GO:0060627,biological_process regulation of vesicle-mediated transport;GO:0061762,biological_process CAMKK-AMPK signaling cascade;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071361,biological_process cellular response to ethanol;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071417,biological_process cellular response to organonitrogen compound;GO:0071456,biological_process cellular response to hypoxia;GO:1901563,biological_process response to camptothecin;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:2000505,biological_process regulation of energy homeostasis;GO:2001274,biological_process negative regulation of glucose import in response to insulin stimulus	PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]; K07198	protein kinase AMP-activated catalytic subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:9376]
ENSG00000074603	10.67	8.25	8.70	9.20	9.57	8.56	0.0334134833501476	4.6588833387062	0.782074191604334	0.948563882801004	15:65442462-65517704:-	DPP8	9;GO:0004177,molecular_function aminopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006955,biological_process immune response;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0008239,molecular_function dipeptidyl-peptidase activity;GO:0016787,molecular_function hydrolase activity	NA	dipeptidyl peptidase 8 [Source:HGNC Symbol%3BAcc:HGNC:16490]
ENSG00000166266	19.77	18.83	20.48	17.34	19.51	21.76	0.0241097467911689	5.52723722988334	0.782151871176063	0.948563882801004	11:108008732-108107776:+	CUL5	23;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004872,molecular_function receptor activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016032,biological_process viral process;GO:0016567,biological_process protein ubiquitination;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031466,cellular_component Cul5-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070588,biological_process calcium ion transmembrane transport;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex;GO:0097193,biological_process intrinsic apoptotic signaling pathway	CUL5; cullin 5; K10612	cullin 5 [Source:HGNC Symbol%3BAcc:HGNC:2556]
ENSG00000163138	12.22	13.96	12.67	13.86	12.63	13.47	-0.0374077764600278	3.83309581803495	0.782258775528334	0.948563882801004	4:20696281-20752907:+	PACRGL	1;GO:0005515,molecular_function protein binding	NA	parkin coregulated like [Source:HGNC Symbol%3BAcc:HGNC:28442]
ENSG00000254469	2.14	2.67	1.16	2.00	2.85	1.54	-0.105494201027731	0.86845150063567	0.782280550087318	0.948563882801004	11:71865508-71928654:-	AP002495.1	4;GO:0000012,biological_process single strand break repair;GO:0003684,molecular_function damaged DNA binding;GO:0005634,cellular_component nucleus;GO:0006284,biological_process base-excision repair	NA	Putative short transient receptor potential channel 2-like protein  [Source:UniProtKB/Swiss-Prot%3BAcc:Q6ZNB5]
ENSG00000065183	19.43	19.92	19.74	19.04	20.92	18.81	0.0194383503930721	5.82552413355629	0.782380469761204	0.948592378506136	1:117929719-117966542:+	WDR3	10;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030515,molecular_function snoRNA binding;GO:0031965,cellular_component nuclear membrane;GO:0032040,cellular_component small-subunit processome;GO:0034388,cellular_component Pwp2p-containing subcomplex of 90S preribosome	DIP2, UTP12, WDR3; U3 small nucleolar RNA-associated protein 12; K14556	WD repeat domain 3 [Source:HGNC Symbol%3BAcc:HGNC:12755]
ENSG00000170006	2.71	2.50	4.36	4.04	2.64	3.68	-0.0888833207115888	1.05395869382137	0.782699558833399	0.948660174452484	4:152618631-152680165:-	TMEM154	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 154 [Source:HGNC Symbol%3BAcc:HGNC:26489]
ENSG00000122008	6.71	7.79	8.22	7.22	7.26	7.94	0.0272863281674245	4.34666253955553	0.782718375451212	0.948660174452484	5:75511755-75601144:+	POLK	19;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019985,biological_process translesion synthesis;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042276,biological_process error-prone translesion synthesis;GO:0046872,molecular_function metal ion binding;GO:0071897,biological_process DNA biosynthetic process	POLK; DNA polymerase kappa [EC:2.7.7.7]; K03511	DNA polymerase kappa [Source:HGNC Symbol%3BAcc:HGNC:9183]
ENSG00000177383	25.77	26.98	26.93	27.80	24.79	29.09	-0.0270145310292561	4.6402172487579	0.782764847360056	0.948660174452484	3:184710366-184712002:-	MAGEF1	2;GO:0005515,molecular_function protein binding;GO:0070062,cellular_component extracellular exosome	NA	MAGE family member F1 [Source:HGNC Symbol%3BAcc:HGNC:29639]
ENSG00000065308	32.96	33.23	30.57	31.37	30.82	33.83	0.0201321134464203	5.16278539844081	0.782944586574397	0.948660174452484	6:52497401-52576915:-	TRAM2	7;GO:0005515,molecular_function protein binding;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032964,biological_process collagen biosynthetic process;GO:0045048,biological_process protein insertion into ER membrane	NA	translocation associated membrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16855]
ENSG00000275023	20.48	19.10	21.86	20.60	19.50	21.07	0.0207450265619889	6.18497134692447	0.783042033027294	0.948660174452484	17:38705541-38729803:+	MLLT6	10;GO:0003014,biological_process renal system process;GO:0005515,molecular_function protein binding;GO:0007588,biological_process excretion;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0035811,biological_process negative regulation of urine volume;GO:0035812,biological_process renal sodium excretion;GO:0036359,biological_process renal potassium excretion;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:2001161,biological_process negative regulation of histone H3-K79 methylation	NA	MLLT6%2C PHD finger containing [Source:HGNC Symbol%3BAcc:HGNC:7138]
ENSG00000058272	14.90	15.70	16.33	15.96	15.24	15.47	0.0192017173648255	5.64434169086226	0.783146147076852	0.948660174452484	12:79773562-79935460:-	PPP1R12A	29;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000278,biological_process mitotic cell cycle;GO:0000776,cellular_component kinetochore;GO:0004857,molecular_function enzyme inhibitor activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006470,biological_process protein dephosphorylation;GO:0007098,biological_process centrosome cycle;GO:0007165,biological_process signal transduction;GO:0015629,cellular_component actin cytoskeleton;GO:0019208,molecular_function phosphatase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0030018,cellular_component Z disc;GO:0030155,biological_process regulation of cell adhesion;GO:0031672,cellular_component A band;GO:0035507,biological_process regulation of myosin-light-chain-phosphatase activity;GO:0035508,biological_process positive regulation of myosin-light-chain-phosphatase activity;GO:0035690,biological_process cellular response to drug;GO:0043086,biological_process negative regulation of catalytic activity;GO:0043292,cellular_component contractile fiber;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046822,biological_process regulation of nucleocytoplasmic transport;GO:0071889,molecular_function 14-3-3 protein binding;GO:0072357,cellular_component PTW/PP1 phosphatase complex	PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A; K06270	protein phosphatase 1 regulatory subunit 12A [Source:HGNC Symbol%3BAcc:HGNC:7618]
ENSG00000164081	46.96	43.41	42.91	41.26	47.20	43.99	0.0226944773483327	5.38615542591717	0.783163829675549	0.948660174452484	3:51662692-51704323:+	TEX264	5;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0031093,cellular_component platelet alpha granule lumen;GO:0070062,cellular_component extracellular exosome	NA	testis expressed 264 [Source:HGNC Symbol%3BAcc:HGNC:30247]
ENSG00000149091	10.31	10.23	9.61	10.38	9.57	10.01	0.0198919704279896	5.35970149894964	0.783173732877327	0.948660174452484	11:46332904-46380554:+	DGKZ	24;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0030027,cellular_component lamellipodium;GO:0030168,biological_process platelet activation;GO:0035556,biological_process intracellular signal transduction;GO:0046339,biological_process diacylglycerol metabolic process;GO:0046486,biological_process glycerolipid metabolic process;GO:0046834,biological_process lipid phosphorylation;GO:0046872,molecular_function metal ion binding	dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]; K00901	diacylglycerol kinase zeta [Source:HGNC Symbol%3BAcc:HGNC:2857]
ENSG00000125482	8.38	9.33	8.70	8.38	9.08	9.58	-0.0286734271536666	4.60452621252701	0.783262525254306	0.948660174452484	9:132375547-132406851:-	TTF1	21;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001135,molecular_function transcription factor activity, RNA polymerase II transcription factor recruiting;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0008156,biological_process negative regulation of DNA replication;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044267,biological_process cellular protein metabolic process	TTF1; transcription termination factor 1; K15225	transcription termination factor 1 [Source:HGNC Symbol%3BAcc:HGNC:12397]
ENSG00000105771	23.84	25.17	24.01	24.90	22.38	25.18	0.0197691330413823	5.28887285215759	0.783314691503063	0.948660174452484	19:43727991-43754990:-	SMG9	8;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001654,biological_process eye development;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0042802,molecular_function identical protein binding	NA	SMG9%2C nonsense mediated mRNA decay factor [Source:HGNC Symbol%3BAcc:HGNC:25763]
ENSG00000009307	272.38	265.07	270.39	275.95	267.10	280.33	-0.0156033150568679	9.42831479324752	0.783330037498732	0.948660174452484	1:114716912-114758676:-	CSDE1	13;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008584,biological_process male gonad development;GO:0070937,cellular_component CRD-mediated mRNA stability complex;GO:0070966,biological_process nuclear-transcribed mRNA catabolic process, no-go decay	NA	cold shock domain containing E1 [Source:HGNC Symbol%3BAcc:HGNC:29905]
ENSG00000133106	3.22	2.87	2.57	2.80	2.59	2.97	0.0627745992837867	1.86691301882773	0.783404060098365	0.948660174452484	13:42886387-42992271:-	EPSTI1	NA	NA	epithelial stromal interaction 1 [Source:HGNC Symbol%3BAcc:HGNC:16465]
ENSG00000146122	2.31	2.10	2.10	1.96	2.66	1.73	0.0531769063567815	2.88024189691573	0.783429908024846	0.948660174452484	6:39792297-39904877:+	DAAM2	6;GO:0003779,molecular_function actin binding;GO:0007368,biological_process determination of left/right symmetry;GO:0016043,biological_process cellular component organization;GO:0017048,molecular_function Rho GTPase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0070062,cellular_component extracellular exosome	DAAM; dishevelled associated activator of morphogenesis; K04512	dishevelled associated activator of morphogenesis 2 [Source:HGNC Symbol%3BAcc:HGNC:18143]
ENSG00000130052	22.94	25.10	23.00	23.76	24.43	24.29	-0.0198462180390361	6.30931455609757	0.783722100423462	0.948902281799341	X:68647665-68725842:+	STARD8	8;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0030054,cellular_component cell junction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	StAR related lipid transfer domain containing 8 [Source:HGNC Symbol%3BAcc:HGNC:19161]
ENSG00000084754	100.80	107.43	97.05	102.29	108.53	100.77	-0.018442567148035	7.93389933907625	0.783782735461906	0.948902281799341	2:26190634-26244726:-	HADHA	26;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0003824,molecular_function catalytic activity;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0003985,molecular_function acetyl-CoA C-acetyltransferase activity;GO:0003988,molecular_function acetyl-CoA C-acyltransferase activity;GO:0004300,molecular_function enoyl-CoA hydratase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016507,cellular_component mitochondrial fatty acid beta-oxidation multienzyme complex;GO:0016508,molecular_function long-chain-enoyl-CoA hydratase activity;GO:0016509,molecular_function long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0016829,molecular_function lyase activity;GO:0031012,cellular_component extracellular matrix;GO:0032403,molecular_function protein complex binding;GO:0032868,biological_process response to insulin;GO:0035965,biological_process cardiolipin acyl-chain remodeling;GO:0042493,biological_process response to drug;GO:0042645,cellular_component mitochondrial nucleoid;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process	HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]; K07515	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein)%2C alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:4801]
ENSG00000197647	2.90	2.71	2.38	3.04	2.55	2.73	-0.0477647191121019	2.67439006979132	0.784062746294816	0.949042070702911	19:12014731-12035741:-	ZNF433	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 433 [Source:HGNC Symbol%3BAcc:HGNC:20811]
ENSG00000158062	22.57	20.36	23.94	22.88	20.44	23.10	0.0257304154650665	5.14028259705008	0.784150631506384	0.949042070702911	1:26281327-26318363:-	UBXN11	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	NA	UBX domain protein 11 [Source:HGNC Symbol%3BAcc:HGNC:30600]
ENSG00000168216	51.79	54.86	50.66	53.33	51.22	51.96	0.017228447088593	6.40758749985873	0.784209979342927	0.949042070702911	6:69675801-69797111:-	LMBRD1	17;GO:0005158,molecular_function insulin receptor binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0009235,biological_process cobalamin metabolic process;GO:0015235,molecular_function cobalamin transporter activity;GO:0015889,biological_process cobalamin transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0031419,molecular_function cobalamin binding;GO:0038016,biological_process insulin receptor internalization;GO:0045334,cellular_component clathrin-coated endocytic vesicle;GO:0046325,biological_process negative regulation of glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0051898,biological_process negative regulation of protein kinase B signaling	LMBRD1; LMBR1 domain-containing protein 1; K14617	LMBR1 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:23038]
ENSG00000185010	0.27	0.30	0.34	0.32	0.34	0.21	0.0846967100854286	1.16542381127855	0.784377418378183	0.949042070702911	X:154835787-155026940:-	F8	21;GO:0000139,cellular_component Golgi membrane;GO:0002576,biological_process platelet degranulation;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006953,biological_process acute-phase response;GO:0007596,biological_process blood coagulation;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0007599,biological_process hemostasis;GO:0016491,molecular_function oxidoreductase activity;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0030168,biological_process platelet activation;GO:0031093,cellular_component platelet alpha granule lumen;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0046872,molecular_function metal ion binding;GO:0048208,biological_process COPII vesicle coating;GO:0055114,biological_process oxidation-reduction process	F8; coagulation factor VIII; K03899	coagulation factor VIII [Source:HGNC Symbol%3BAcc:HGNC:3546]
ENSG00000163635	7.48	6.13	9.32	7.57	7.43	7.62	0.0395687740086907	4.47660110556187	0.784382235628024	0.949042070702911	3:63864556-64003462:+	ATXN7	21;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006997,biological_process nucleus organization;GO:0007601,biological_process visual perception;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016363,cellular_component nuclear matrix;GO:0016578,biological_process histone deubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042326,biological_process negative regulation of phosphorylation;GO:0043569,biological_process negative regulation of insulin-like growth factor receptor signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	ataxin 7 [Source:HGNC Symbol%3BAcc:HGNC:10560]
ENSG00000188343	30.83	33.06	30.65	33.91	31.19	28.66	0.0218447121840024	5.40606023307177	0.784428147125152	0.949042070702911	8:93698560-93731527:+	FAM92A	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097546,cellular_component ciliary base	NA	family with sequence similarity 92 member A [Source:HGNC Symbol%3BAcc:HGNC:30452]
ENSG00000137310	23.08	25.22	26.08	26.46	21.77	25.35	0.0251543900247114	4.80720338223919	0.784464718139722	0.949042070702911	6:31158541-31167159:+	TCF19	8;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008283,biological_process cell proliferation;GO:0046872,molecular_function metal ion binding	NA	transcription factor 19 [Source:HGNC Symbol%3BAcc:HGNC:11629]
ENSG00000101109	14.01	13.82	14.65	15.83	13.55	14.25	-0.0251399848571087	4.54845110099673	0.784509843509431	0.949042070702911	20:44966473-45079959:+	STK4	52;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000902,biological_process cell morphogenesis;GO:0001569,biological_process patterning of blood vessels;GO:0001841,biological_process neural tube formation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003157,biological_process endocardium development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007417,biological_process central nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030216,biological_process keratinocyte differentiation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032092,biological_process positive regulation of protein binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035329,biological_process hippo signaling;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0046621,biological_process negative regulation of organ growth;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0050821,biological_process protein stabilization;GO:0060215,biological_process primitive hemopoiesis;GO:0060706,biological_process cell differentiation involved in embryonic placenta development;GO:0060800,biological_process regulation of cell differentiation involved in embryonic placenta development;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097284,biological_process hepatocyte apoptotic process;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	STK4, MST1; serine/threonine kinase 4; K04411	serine/threonine kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:11408]
ENSG00000198258	393.76	378.33	365.32	362.39	411.77	356.73	0.0206298505081243	6.37483711291256	0.784817683591063	0.949309522513303	19:9827891-9830115:+	UBL5	9;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006464,biological_process cellular protein modification process;GO:0008150,biological_process biological_process;GO:0031386,molecular_function protein tag;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	UBL5, HUB1; ubiquitin-like protein 5; K13113	ubiquitin like 5 [Source:HGNC Symbol%3BAcc:HGNC:13736]
ENSG00000042980	1.51	1.28	1.52	1.27	1.57	1.37	0.0606172784637881	1.87659305913056	0.784883882184325	0.949309522513303	8:24294039-24359018:+	ADAM28	12;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007283,biological_process spermatogenesis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	ADAM metallopeptidase domain 28 [Source:HGNC Symbol%3BAcc:HGNC:206]
ENSG00000106635	34.87	30.69	33.65	33.66	31.43	36.84	-0.0235549654587861	4.74653402305922	0.785071717361998	0.949444195987381	7:73536355-73558002:-	BCL7B	7;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0006915,biological_process apoptotic process;GO:0008150,biological_process biological_process;GO:0016055,biological_process Wnt signaling pathway;GO:0030154,biological_process cell differentiation	NA	BCL tumor suppressor 7B [Source:HGNC Symbol%3BAcc:HGNC:1005]
ENSG00000164828	65.04	63.38	64.62	66.61	64.88	65.33	-0.0159844288971074	7.64367784816782	0.785193689686808	0.949499198254491	7:816614-896435:+	SUN1	26;GO:0001503,biological_process ossification;GO:0002080,cellular_component acrosomal membrane;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0005737,cellular_component cytoplasm;GO:0006998,biological_process nuclear envelope organization;GO:0007129,biological_process synapsis;GO:0007283,biological_process spermatogenesis;GO:0009612,biological_process response to mechanical stimulus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021817,biological_process nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0030154,biological_process cell differentiation;GO:0031965,cellular_component nuclear membrane;GO:0034993,cellular_component LINC complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043495,molecular_function protein anchor;GO:0051321,biological_process meiotic cell cycle;GO:0051642,biological_process centrosome localization;GO:0070197,biological_process meiotic attachment of telomere to nuclear envelope;GO:0090286,biological_process cytoskeletal anchoring at nuclear membrane;GO:0090292,biological_process nuclear matrix anchoring at nuclear membrane	NA	Sad1 and UNC84 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18587]
ENSG00000137198	3.21	4.06	3.91	4.63	3.37	2.79	0.058397319967087	1.97021102101754	0.785385945403444	0.949554008300634	6:16238579-16295549:+	GMPR	11;GO:0003824,molecular_function catalytic activity;GO:0003920,molecular_function GMP reductase activity;GO:0005829,cellular_component cytosol;GO:0006144,biological_process purine nucleobase metabolic process;GO:0009117,biological_process nucleotide metabolic process;GO:0009409,biological_process response to cold;GO:0016491,molecular_function oxidoreductase activity;GO:0043101,biological_process purine-containing compound salvage;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:1902560,cellular_component GMP reductase complex	E1.7.1.7, guaC; GMP reductase [EC:1.7.1.7]; K00364	guanosine monophosphate reductase [Source:HGNC Symbol%3BAcc:HGNC:4376]
ENSG00000056277	3.90	3.80	4.16	4.17	3.64	3.85	0.0408875194316313	3.14200967058474	0.785397188000733	0.949554008300634	X:130202710-130268899:-	ZNF280C	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 280C [Source:HGNC Symbol%3BAcc:HGNC:25955]
ENSG00000113369	125.84	110.88	135.11	120.27	117.86	131.46	0.0219884175904315	7.26517203831483	0.785468505375889	0.949554008300634	5:91368723-91383359:-	ARRDC3	16;GO:0001659,biological_process temperature homeostasis;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0031651,biological_process negative regulation of heat generation;GO:0031699,molecular_function beta-3 adrenergic receptor binding;GO:0043588,biological_process skin development;GO:0044252,biological_process negative regulation of multicellular organismal metabolic process;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0060613,biological_process fat pad development;GO:0071879,biological_process positive regulation of adrenergic receptor signaling pathway;GO:0090327,biological_process negative regulation of locomotion involved in locomotory behavior	NA	arrestin domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:29263]
ENSG00000185800	9.08	7.89	8.51	8.18	8.53	8.60	0.0273346215514226	4.44178760919458	0.785750208227848	0.949799032773629	19:45782946-45792802:-	DMWD	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0016579,biological_process protein deubiquitination	NA	DM1 locus%2C WD repeat containing [Source:HGNC Symbol%3BAcc:HGNC:2936]
ENSG00000172757	1065.36	1204.28	982.66	1093.25	1239.38	1001.95	-0.0246303916339627	9.40022716126865	0.785824221911316	0.949799032773629	11:65823021-65862026:-	CFL1	41;GO:0000281,biological_process mitotic cytokinesis;GO:0001755,biological_process neural crest cell migration;GO:0001842,biological_process neural fold formation;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007010,biological_process cytoskeleton organization;GO:0007015,biological_process actin filament organization;GO:0007266,biological_process Rho protein signal transduction;GO:0009615,biological_process response to virus;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030010,biological_process establishment of cell polarity;GO:0030036,biological_process actin cytoskeleton organization;GO:0030042,biological_process actin filament depolymerization;GO:0030043,biological_process actin filament fragmentation;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031012,cellular_component extracellular matrix;GO:0031258,cellular_component lamellipodium membrane;GO:0031982,cellular_component vesicle;GO:0032587,cellular_component ruffle membrane;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043200,biological_process response to amino acid;GO:0044794,biological_process positive regulation by host of viral process;GO:0051015,molecular_function actin filament binding;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0070062,cellular_component extracellular exosome	NA	cofilin 1 [Source:HGNC Symbol%3BAcc:HGNC:1874]
ENSG00000214654	8.36	8.29	7.78	8.45	7.74	7.81	0.0353534853395676	3.18351929325088	0.785943518584361	0.949850734708176	9:120793550-120799918:+	AL161911.1	8;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	Putative UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase LOC100288842  [Source:UniProtKB/Swiss-Prot%3BAcc:A8MXE2]
ENSG00000136379	4.01	3.39	2.98	3.64	3.53	3.78	-0.0620579932386959	1.8765923331914	0.786106553025793	0.949897849495171	15:80679683-80755621:+	ABHD17C	1;GO:0016787,molecular_function hydrolase activity	NA	abhydrolase domain containing 17C [Source:HGNC Symbol%3BAcc:HGNC:26925]
ENSG00000140682	42.73	40.23	42.46	41.84	39.70	43.36	0.0192732021588102	5.85810468893661	0.786232485910762	0.949897849495171	16:31471584-31477960:+	TGFB1I1	30;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007155,biological_process cell adhesion;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009408,biological_process response to heat;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016055,biological_process Wnt signaling pathway;GO:0016331,biological_process morphogenesis of embryonic epithelium;GO:0016363,cellular_component nuclear matrix;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030579,biological_process ubiquitin-dependent SMAD protein catabolic process;GO:0030855,biological_process epithelial cell differentiation;GO:0031012,cellular_component extracellular matrix;GO:0045165,biological_process cell fate commitment;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048495,molecular_function Roundabout binding;GO:0050681,molecular_function androgen receptor binding;GO:0070411,molecular_function I-SMAD binding	NA	transforming growth factor beta 1 induced transcript 1 [Source:HGNC Symbol%3BAcc:HGNC:11767]
ENSG00000175634	18.07	16.28	17.24	18.42	17.61	16.93	-0.0210082141727207	4.73816813164593	0.786341603132756	0.949897849495171	11:67428459-67435408:+	RPS6KB2	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004711,molecular_function ribosomal protein S6 kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006412,biological_process translation;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction;GO:0042277,molecular_function peptide binding;GO:0043491,biological_process protein kinase B signaling;GO:0045948,biological_process positive regulation of translational initiation	RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]; K04688	ribosomal protein S6 kinase B2 [Source:HGNC Symbol%3BAcc:HGNC:10437]
ENSG00000086598	236.21	244.27	233.31	228.10	237.49	245.44	0.0166042404509986	7.21337220288145	0.786360331262286	0.949897849495171	12:123584530-123598577:+	TMED2	42;GO:0000139,cellular_component Golgi membrane;GO:0001701,biological_process in utero embryonic development;GO:0001756,biological_process somitogenesis;GO:0001843,biological_process neural tube closure;GO:0001892,biological_process embryonic placenta development;GO:0001893,biological_process maternal placenta development;GO:0001947,biological_process heart looping;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0010628,biological_process positive regulation of gene expression;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0030137,cellular_component COPI-coated vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032525,biological_process somite rostral/caudal axis specification;GO:0032580,cellular_component Golgi cisterna membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034260,biological_process negative regulation of GTPase activity;GO:0035264,biological_process multicellular organism growth;GO:0035459,biological_process cargo loading into vesicle;GO:0036342,biological_process post-anal tail morphogenesis;GO:0042589,cellular_component zymogen granule membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048205,biological_process COPI coating of Golgi vesicle;GO:0048208,biological_process COPII vesicle coating;GO:0048598,biological_process embryonic morphogenesis;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0072661,biological_process protein targeting to plasma membrane	NA	transmembrane p24 trafficking protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16996]
ENSG00000152234	167.35	174.42	146.95	157.75	171.05	157.00	0.0199478738767953	8.39870298237449	0.786365125385674	0.949897849495171	18:46080247-46104334:-	ATP5A1	35;GO:0000166,molecular_function nucleotide binding;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008180,cellular_component COP9 signalosome;GO:0009790,biological_process embryo development;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0031012,cellular_component extracellular matrix;GO:0032559,molecular_function adenyl ribonucleotide binding;GO:0042288,molecular_function MHC class I protein binding;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0043209,cellular_component myelin sheath;GO:0043532,molecular_function angiostatin binding;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045259,cellular_component proton-transporting ATP synthase complex;GO:0045261,cellular_component proton-transporting ATP synthase complex, catalytic core F(1);GO:0046034,biological_process ATP metabolic process;GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF1A, ATP5A1, ATP1; F-type H+-transporting ATPase subunit alpha; K02132	ATP synthase%2C H+ transporting%2C mitochondrial F1 complex%2C alpha subunit 1%2C cardiac muscle [Source:HGNC Symbol%3BAcc:HGNC:823]
ENSG00000070476	7.43	6.97	7.14	7.23	7.00	7.09	0.02852297930973	4.21634088826671	0.786640795898718	0.949969506025376	3:126437600-126475919:-	ZXDC	11;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030275,molecular_function LRR domain binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070742,molecular_function C2H2 zinc finger domain binding	NA	ZXD family zinc finger C [Source:HGNC Symbol%3BAcc:HGNC:28160]
ENSG00000204366	10.82	13.33	11.97	13.27	11.90	11.90	-0.0339181615440587	4.07944260067474	0.78667485582464	0.949969506025376	6:31899606-31901992:-	ZBTB12	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:19066]
ENSG00000117281	2.50	2.57	3.54	3.28	3.11	1.79	0.0983566066035323	1.08990299649199	0.786711521440226	0.949969506025376	1:145719470-145739288:+	CD160	14;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006968,biological_process cellular defense response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031225,cellular_component anchored component of membrane;GO:0032393,molecular_function MHC class I receptor activity;GO:0046658,cellular_component anchored component of plasma membrane;GO:0050776,biological_process regulation of immune response;GO:0050829,biological_process defense response to Gram-negative bacterium	NA	CD160 molecule [Source:HGNC Symbol%3BAcc:HGNC:17013]
ENSG00000235162	266.13	272.85	247.04	256.30	262.70	263.13	0.0174366596904557	6.49730323772605	0.786839106315542	0.949969506025376	12:105235289-105396097:+	C12orf75	NA	NA	chromosome 12 open reading frame 75 [Source:HGNC Symbol%3BAcc:HGNC:35164]
ENSG00000132824	78.44	76.57	81.69	78.41	77.45	80.03	0.0175379071623441	6.80757069207267	0.78699146284045	0.949969506025376	20:44496220-44522109:-	SERINC3	19;GO:0000139,cellular_component Golgi membrane;GO:0002376,biological_process immune system process;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006564,biological_process L-serine biosynthetic process;GO:0006658,biological_process phosphatidylserine metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006810,biological_process transport;GO:0009597,biological_process detection of virus;GO:0015194,molecular_function L-serine transmembrane transporter activity;GO:0015825,biological_process L-serine transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045087,biological_process innate immune response;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051607,biological_process defense response to virus;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1905361,molecular_function L-serine transporter activity	NA	serine incorporator 3 [Source:HGNC Symbol%3BAcc:HGNC:11699]
ENSG00000197535	7.12	6.44	6.75	7.03	6.66	6.51	0.0228671986962568	5.26299091871117	0.787040985032039	0.949969506025376	15:52307282-52529050:-	MYO5A	66;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0001750,cellular_component photoreceptor outer segment;GO:0003723,molecular_function RNA binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005777,cellular_component peroxisome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0005884,cellular_component actin filament;GO:0006582,biological_process melanin metabolic process;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0007268,biological_process chemical synaptic transmission;GO:0007601,biological_process visual perception;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016459,cellular_component myosin complex;GO:0016461,cellular_component unconventional myosin complex;GO:0017137,molecular_function Rab GTPase binding;GO:0030048,biological_process actin filament-based movement;GO:0030050,biological_process vesicle transport along actin filament;GO:0030073,biological_process insulin secretion;GO:0030141,cellular_component secretory granule;GO:0030318,biological_process melanocyte differentiation;GO:0030426,cellular_component growth cone;GO:0031585,biological_process regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0031982,cellular_component vesicle;GO:0031987,biological_process locomotion involved in locomotory behavior;GO:0032252,biological_process secretory granule localization;GO:0032400,biological_process melanosome localization;GO:0032402,biological_process melanosome transport;GO:0032433,cellular_component filopodium tip;GO:0032593,cellular_component insulin-responsive compartment;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035371,cellular_component microtubule plus-end;GO:0042438,biological_process melanin biosynthetic process;GO:0042470,cellular_component melanosome;GO:0042476,biological_process odontogenesis;GO:0042552,biological_process myelination;GO:0042641,cellular_component actomyosin;GO:0042759,biological_process long-chain fatty acid biosynthetic process;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043473,biological_process pigmentation;GO:0048066,biological_process developmental pigmentation;GO:0048820,biological_process hair follicle maturation;GO:0050808,biological_process synapse organization;GO:0051015,molecular_function actin filament binding;GO:0051643,biological_process endoplasmic reticulum localization;GO:0055037,cellular_component recycling endosome;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane;GO:0097718,molecular_function disordered domain specific binding	MYO5; myosin V; K10357	myosin VA [Source:HGNC Symbol%3BAcc:HGNC:7602]
ENSG00000085491	38.15	38.81	38.17	35.85	37.75	40.92	0.0180765759541924	5.92359541741864	0.787169140879239	0.949969506025376	1:108134035-108200849:-	SLC25A24	16;GO:0005347,molecular_function ATP transmembrane transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0010941,biological_process regulation of cell death;GO:0015217,molecular_function ADP transmembrane transporter activity;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034599,biological_process cellular response to oxidative stress;GO:0046872,molecular_function metal ion binding;GO:0055085,biological_process transmembrane transport;GO:0071277,biological_process cellular response to calcium ion	NA	solute carrier family 25 member 24 [Source:HGNC Symbol%3BAcc:HGNC:20662]
ENSG00000138071	187.02	188.73	176.33	183.38	190.87	188.71	-0.0167909316723618	7.84183470100439	0.787185079694259	0.949969506025376	2:65227752-65271253:+	ACTR2	45;GO:0000166,molecular_function nucleotide binding;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006928,biological_process movement of cell or subcellular component;GO:0007015,biological_process actin filament organization;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008306,biological_process associative learning;GO:0008356,biological_process asymmetric cell division;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016344,biological_process meiotic chromosome movement towards spindle pole;GO:0016482,biological_process cytosolic transport;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030478,cellular_component actin cap;GO:0033206,biological_process meiotic cytokinesis;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0035578,cellular_component azurophil granule lumen;GO:0035902,biological_process response to immobilization stress;GO:0035984,biological_process cellular response to trichostatin A;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0043312,biological_process neutrophil degranulation;GO:0045471,biological_process response to ethanol;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0051321,biological_process meiotic cell cycle;GO:0051653,biological_process spindle localization;GO:0060271,biological_process cilium morphogenesis;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0061024,biological_process membrane organization;GO:0061825,cellular_component podosome core;GO:0070062,cellular_component extracellular exosome;GO:0071437,cellular_component invadopodium;GO:1904813,cellular_component ficolin-1-rich granule lumen	ACTR2, ARP2; actin-related protein 2; K17260	ARP2 actin related protein 2 homolog [Source:HGNC Symbol%3BAcc:HGNC:169]
ENSG00000197774	1.93	2.19	2.14	1.78	2.40	1.79	0.0733271147401644	1.29775046123273	0.78721311551998	0.949969506025376	16:1773206-1781708:+	EME2	16;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008821,molecular_function crossover junction endodeoxyribonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0031297,biological_process replication fork processing;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0048476,cellular_component Holliday junction resolvase complex;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	EME2; crossover junction endonuclease EME2; K10883	essential meiotic structure-specific endonuclease subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:27289]
ENSG00000156463	7.82	7.21	6.83	8.11	7.14	7.27	-0.0296269595538363	4.03105252550256	0.787261685635287	0.949969506025376	5:145936578-146081791:+	SH3RF2	9;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019902,molecular_function phosphatase binding;GO:0046872,molecular_function metal ion binding	NA	SH3 domain containing ring finger 2 [Source:HGNC Symbol%3BAcc:HGNC:26299]
ENSG00000186300	4.12	4.82	4.69	4.57	4.87	4.63	-0.0408627750102653	3.14331758938368	0.787266277973338	0.949969506025376	19:2841434-2860484:+	ZNF555	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 555 [Source:HGNC Symbol%3BAcc:HGNC:28382]
ENSG00000091436	20.34	18.92	23.31	20.19	21.13	22.83	-0.0213546528528688	5.88122336382207	0.787412413896994	0.950008972344406	2:173075434-173268010:+	MAP3K20	34;GO:0000075,biological_process cell cycle checkpoint;GO:0000077,biological_process DNA damage checkpoint;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0000287,molecular_function magnesium ion binding;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007257,biological_process activation of JUN kinase activity;GO:0008219,biological_process cell death;GO:0008283,biological_process cell proliferation;GO:0009314,biological_process response to radiation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0035556,biological_process intracellular signal transduction;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0060173,biological_process limb development	ZAK, MLTK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]; K04424	mitogen-activated protein kinase kinase kinase 20 [Source:HGNC Symbol%3BAcc:HGNC:17797]
ENSG00000198440	2.48	2.35	2.85	2.94	2.98	2.18	-0.0539561653690753	2.21684100112221	0.787573682015873	0.950008972344406	19:56397965-56436035:+	ZNF583	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 583 [Source:HGNC Symbol%3BAcc:HGNC:26427]
ENSG00000241343	3.57	4.83	5.50	4.84	3.98	4.40	0.0740499383554097	1.25232359415006	0.78772817878273	0.950008972344406	X:101390823-101396154:+	RPL36A	17;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L44e, RPL44; large subunit ribosomal protein L44e; K02929	ribosomal protein L36a [Source:HGNC Symbol%3BAcc:HGNC:10359]
ENSG00000101255	238.48	223.40	243.04	237.00	229.83	252.60	-0.017029859069254	8.10099091697683	0.787747854467675	0.950008972344406	20:362834-397559:+	TRIB3	34;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0004672,molecular_function protein kinase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006915,biological_process apoptotic process;GO:0010827,biological_process regulation of glucose transport;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031965,cellular_component nuclear membrane;GO:0032092,biological_process positive regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043405,biological_process regulation of MAP kinase activity;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0055106,molecular_function ubiquitin-protein transferase regulator activity;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	tribbles pseudokinase 3 [Source:HGNC Symbol%3BAcc:HGNC:16228]
ENSG00000153936	16.71	17.07	15.84	14.64	18.87	15.46	0.0301407692144104	4.14585015987507	0.787825053806106	0.950008972344406	1:86914647-87109998:+	HS2ST1	8;GO:0000139,cellular_component Golgi membrane;GO:0004394,molecular_function heparan sulfate 2-O-sulfotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity	HS2ST1; heparan sulfate 2-O-sulfotransferase HS2ST1 [EC:2.8.2.-]; K02513	heparan sulfate 2-O-sulfotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:5193]
ENSG00000167770	77.86	83.68	78.80	84.41	78.11	82.70	-0.0193026364543599	6.34875316953312	0.787840404922559	0.950008972344406	11:63985852-64001811:+	OTUB1	24;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006508,biological_process proteolysis;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019784,molecular_function NEDD8-specific protease activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043130,molecular_function ubiquitin binding;GO:0070062,cellular_component extracellular exosome;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0071347,biological_process cellular response to interleukin-1;GO:1901315,biological_process negative regulation of histone H2A K63-linked ubiquitination;GO:2000780,biological_process negative regulation of double-strand break repair	NA	OTU deubiquitinase%2C ubiquitin aldehyde binding 1 [Source:HGNC Symbol%3BAcc:HGNC:23077]
ENSG00000140262	25.70	23.65	24.09	24.97	25.26	24.81	-0.0169859922859784	5.81557069649394	0.787942604206637	0.950008972344406	15:56918622-57299281:+	TCF12	38;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007517,biological_process muscle organ development;GO:0008134,molecular_function transcription factor binding;GO:0010628,biological_process positive regulation of gene expression;GO:0016607,cellular_component nuclear speck;GO:0030154,biological_process cell differentiation;GO:0035326,molecular_function enhancer binding;GO:0035497,molecular_function cAMP response element binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043425,molecular_function bHLH transcription factor binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0070888,molecular_function E-box binding;GO:0071837,molecular_function HMG box domain binding;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	NA	transcription factor 12 [Source:HGNC Symbol%3BAcc:HGNC:11623]
ENSG00000205084	7.62	7.87	8.48	7.33	7.70	8.56	0.033888026638254	3.14194410738561	0.788058754352649	0.950008972344406	16:75536743-75556286:-	TMEM231	18;GO:0001701,biological_process in utero embryonic development;GO:0001944,biological_process vasculature development;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0032880,biological_process regulation of protein localization;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0043010,biological_process camera-type eye development;GO:0060170,cellular_component ciliary membrane;GO:0060271,biological_process cilium morphogenesis;GO:0060563,biological_process neuroepithelial cell differentiation	NA	transmembrane protein 231 [Source:HGNC Symbol%3BAcc:HGNC:37234]
ENSG00000078674	16.49	15.08	16.49	16.65	16.27	16.16	-0.01688138267208	6.66462055320318	0.788067441049819	0.950008972344406	8:17922839-18029944:+	PCM1	35;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000242,cellular_component pericentriolar material;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0022027,biological_process interkinetic nuclear migration;GO:0030030,biological_process cell projection organization;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031965,cellular_component nuclear membrane;GO:0034451,cellular_component centriolar satellite;GO:0034453,biological_process microtubule anchoring;GO:0034454,biological_process microtubule anchoring at centrosome;GO:0035176,biological_process social behavior;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043234,cellular_component protein complex;GO:0045177,cellular_component apical part of cell;GO:0050768,biological_process negative regulation of neurogenesis;GO:0060271,biological_process cilium morphogenesis;GO:0071539,biological_process protein localization to centrosome;GO:0090316,biological_process positive regulation of intracellular protein transport;GO:0097150,biological_process neuronal stem cell population maintenance;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1905515,biological_process non-motile cilium assembly	NA	pericentriolar material 1 [Source:HGNC Symbol%3BAcc:HGNC:8727]
ENSG00000232119	76.59	81.15	77.30	82.27	81.15	76.63	-0.0206291172952574	5.46770800487989	0.788092654612596	0.950008972344406	X:120594009-120621074:+	MCTS1	19;GO:0001731,biological_process formation of translation preinitiation complex;GO:0002188,biological_process translation reinitiation;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0032790,biological_process ribosome disassembly;GO:0040008,biological_process regulation of growth;GO:0075522,biological_process IRES-dependent viral translational initiation	NA	MCTS1%2C re-initiation and release factor [Source:HGNC Symbol%3BAcc:HGNC:23357]
ENSG00000080839	6.74	6.04	6.21	5.77	5.93	7.10	0.0278911327530254	4.37353198455525	0.788140852106879	0.950008972344406	20:36996348-37095995:-	RBL1	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0008134,molecular_function transcription factor binding;GO:0010629,biological_process negative regulation of gene expression;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0043550,biological_process regulation of lipid kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051726,biological_process regulation of cell cycle;GO:1990841,molecular_function promoter-specific chromatin binding	RBL1; retinoblastoma-like protein 1; K04681	RB transcriptional corepressor like 1 [Source:HGNC Symbol%3BAcc:HGNC:9893]
ENSG00000167130	5.44	7.63	6.39	5.66	7.01	6.01	0.0540442483486829	2.21888326661582	0.788302208055686	0.950096199399956	9:129081099-129090438:+	DOLPP1	11;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006489,biological_process dolichyl diphosphate biosynthetic process;GO:0008610,biological_process lipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0047874,molecular_function dolichyldiphosphatase activity	DOLPP1; dolichyldiphosphatase [EC:3.6.1.43]; K07252	dolichyldiphosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:29565]
ENSG00000095587	3.80	3.92	2.73	3.02	4.83	3.07	-0.0542308022402308	3.45470352771391	0.788385849908327	0.950096199399956	10:96364605-96513918:-	TLL2	14;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0006508,biological_process proteolysis;GO:0007275,biological_process multicellular organism development;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030154,biological_process cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0048632,biological_process negative regulation of skeletal muscle tissue growth	NA	tolloid like 2 [Source:HGNC Symbol%3BAcc:HGNC:11844]
ENSG00000204371	20.07	23.44	20.65	20.44	22.82	20.41	0.0197935258217753	6.37172300902324	0.788442838155075	0.950096199399956	6:31879758-31897687:-	EHMT2	50;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0002039,molecular_function p53 binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006275,biological_process regulation of DNA replication;GO:0006306,biological_process DNA methylation;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007130,biological_process synaptonemal complex assembly;GO:0007281,biological_process germ cell development;GO:0007286,biological_process spermatid development;GO:0007616,biological_process long-term memory;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0009267,biological_process cellular response to starvation;GO:0009566,biological_process fertilization;GO:0010424,biological_process DNA methylation on cytosine within a CG sequence;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0018027,biological_process peptidyl-lysine dimethylation;GO:0031667,biological_process response to nutrient levels;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0035265,biological_process organ growth;GO:0035690,biological_process cellular response to drug;GO:0036166,biological_process phenotypic switching;GO:0044030,biological_process regulation of DNA methylation;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0046974,molecular_function histone methyltransferase activity (H3-K9 specific);GO:0046976,molecular_function histone methyltransferase activity (H3-K27 specific);GO:0048148,biological_process behavioral response to cocaine;GO:0048665,biological_process neuron fate specification;GO:0051567,biological_process histone H3-K9 methylation;GO:0051569,biological_process regulation of histone H3-K4 methylation;GO:0051570,biological_process regulation of histone H3-K9 methylation;GO:0060992,biological_process response to fungicide;GO:0070734,biological_process histone H3-K27 methylation;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0071314,biological_process cellular response to cocaine;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902902,biological_process negative regulation of autophagosome assembly;GO:1990841,molecular_function promoter-specific chromatin binding	EHMT; [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]; K11420	euchromatic histone lysine methyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:14129]
ENSG00000171130	4.16	5.63	4.88	2.30	6.05	5.61	0.0749789390334839	2.00662002951666	0.788610247306282	0.950205688197717	7:149872967-149880698:+	ATP6V0E2	20;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007035,biological_process vacuolar acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0016241,biological_process regulation of macroautophagy;GO:0016787,molecular_function hydrolase activity;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0042625,molecular_function ATPase coupled ion transmembrane transporter activity;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0090383,biological_process phagosome acidification	ATPeV0E, ATP6H; V-type H+-transporting ATPase subunit e; K02153	ATPase H+ transporting V0 subunit e2 [Source:HGNC Symbol%3BAcc:HGNC:21723]
ENSG00000162244	1258.16	1089.04	1139.91	1230.63	1138.84	1190.94	-0.0181046271158793	9.37817870697969	0.788740634419939	0.950236799488043	3:51993599-51995942:-	RPL29	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007566,biological_process embryo implantation;GO:0008201,molecular_function heparin binding;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045296,molecular_function cadherin binding	RP-L29e, RPL29; large subunit ribosomal protein L29e; K02905	ribosomal protein L29 [Source:HGNC Symbol%3BAcc:HGNC:10331]
ENSG00000036054	21.33	18.69	20.58	19.46	20.56	20.32	0.0227866327136547	5.43308240544617	0.788789171185435	0.950236799488043	3:100260999-100325251:+	TBC1D23	5;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0032680,biological_process regulation of tumor necrosis factor production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0050727,biological_process regulation of inflammatory response	NA	TBC1 domain family member 23 [Source:HGNC Symbol%3BAcc:HGNC:25622]
ENSG00000123240	85.15	79.08	90.60	91.18	80.44	88.90	-0.0190676792850959	7.35036641113124	0.788879061492232	0.950252866599037	10:13099448-13138308:+	OPTN	41;GO:0000042,biological_process protein targeting to Golgi;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000139,cellular_component Golgi membrane;GO:0001920,biological_process negative regulation of receptor recycling;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005776,cellular_component autophagosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0007030,biological_process Golgi organization;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0008219,biological_process cell death;GO:0010508,biological_process positive regulation of autophagy;GO:0016192,biological_process vesicle-mediated transport;GO:0017137,molecular_function Rab GTPase binding;GO:0030674,molecular_function protein binding, bridging;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031593,molecular_function polyubiquitin binding;GO:0034613,biological_process cellular protein localization;GO:0034620,biological_process cellular response to unfolded protein;GO:0042802,molecular_function identical protein binding;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0061734,biological_process parkin-mediated mitophagy in response to mitochondrial depolarization;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:0090161,biological_process Golgi ribbon formation;GO:1904417,biological_process positive regulation of xenophagy	NA	optineurin [Source:HGNC Symbol%3BAcc:HGNC:17142]
ENSG00000108219	34.18	33.15	36.76	31.95	35.62	35.79	0.0242142360708263	4.86786156057253	0.789035261991495	0.950348797506349	10:80454165-80533123:+	TSPAN14	11;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019899,molecular_function enzyme binding;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0051604,biological_process protein maturation;GO:0070821,cellular_component tertiary granule membrane;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	tetraspanin 14 [Source:HGNC Symbol%3BAcc:HGNC:23303]
ENSG00000157657	5.46	7.59	5.77	5.53	7.45	5.41	0.0371842348038787	4.18284260954248	0.789157946019325	0.950392298088899	9:113876281-114056591:+	ZNF618	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 618 [Source:HGNC Symbol%3BAcc:HGNC:29416]
ENSG00000137877	0.35	0.35	0.33	0.37	0.33	0.37	-0.0655695070647083	2.00088970407682	0.789237755740816	0.950392298088899	15:41848143-41894077:-	SPTBN5	25;GO:0000165,biological_process MAPK cascade;GO:0003779,molecular_function actin binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0007041,biological_process lysosomal transport;GO:0007411,biological_process axon guidance;GO:0008091,cellular_component spectrin;GO:0016020,cellular_component membrane;GO:0019894,molecular_function kinesin binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030507,molecular_function spectrin binding;GO:0032029,molecular_function myosin tail binding;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0034452,molecular_function dynactin binding;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043621,molecular_function protein self-association;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051260,biological_process protein homooligomerization;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome;GO:0097381,cellular_component photoreceptor disc membrane	NA	spectrin beta%2C non-erythrocytic 5 [Source:HGNC Symbol%3BAcc:HGNC:15680]
ENSG00000000460	5.57	6.35	5.48	6.34	5.96	5.57	-0.033211343832587	4.01938307677006	0.78930107153778	0.950392298088899	1:169662006-169854080:+	C1orf112	NA	NA	chromosome 1 open reading frame 112 [Source:HGNC Symbol%3BAcc:HGNC:25565]
ENSG00000143379	14.28	13.42	15.28	14.72	14.41	14.83	-0.01733891022921	5.89123644433516	0.789597068408349	0.950521861620957	1:150926262-150964744:+	SETDB1	24;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007265,biological_process Ras protein signal transduction;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0033273,biological_process response to vitamin;GO:0034968,biological_process histone lysine methylation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding;GO:0090309,biological_process positive regulation of methylation-dependent chromatin silencing;GO:1990841,molecular_function promoter-specific chromatin binding	SETDB1; [histone H3]-lysine9 N-trimethyltransferase SETDB1 [EC:2.1.1.355]; K11421	SET domain bifurcated 1 [Source:HGNC Symbol%3BAcc:HGNC:10761]
ENSG00000196141	75.78	86.82	79.66	78.95	87.85	80.66	-0.0201396759173924	7.31222744923929	0.789687402107158	0.950521861620957	2:200305880-200482263:+	SPATS2L	6;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0043234,cellular_component protein complex	NA	spermatogenesis associated serine rich 2 like [Source:HGNC Symbol%3BAcc:HGNC:24574]
ENSG00000059769	19.91	20.31	18.79	18.54	19.89	20.07	0.0214979571004806	4.52380282299119	0.78977903915277	0.950521861620957	9:111631351-111654351:+	DNAJC25	5;GO:0004871,molecular_function signal transducer activity;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	DnaJ heat shock protein family (Hsp40) member C25 [Source:HGNC Symbol%3BAcc:HGNC:34187]
ENSG00000204308	84.10	89.90	85.19	84.44	93.82	86.47	-0.020933509219731	5.56374596145621	0.789835671317263	0.950521861620957	6:32178353-32180793:+	RNF5	30;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008270,molecular_function zinc ion binding;GO:0009617,biological_process response to bacterium;GO:0010507,biological_process negative regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031648,biological_process protein destabilization;GO:0031966,cellular_component mitochondrial membrane;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0044257,biological_process cellular protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0044390,molecular_function ubiquitin-like protein conjugating enzyme binding;GO:0046872,molecular_function metal ion binding;GO:0055085,biological_process transmembrane transport;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904380,biological_process endoplasmic reticulum mannose trimming;GO:2000785,biological_process regulation of autophagosome assembly	RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27]; K10666	ring finger protein 5 [Source:HGNC Symbol%3BAcc:HGNC:10068]
ENSG00000186815	21.77	20.13	22.53	23.52	19.29	23.19	-0.0215127253881175	5.96514348072506	0.789839867390608	0.950521861620957	12:113221049-113298585:+	TPCN1	24;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0010008,cellular_component endosome membrane;GO:0010508,biological_process positive regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042802,molecular_function identical protein binding;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0072345,molecular_function NAADP-sensitive calcium-release channel activity;GO:0086010,biological_process membrane depolarization during action potential	TPCN1; two pore calcium channel protein 1; K16896	two pore segment channel 1 [Source:HGNC Symbol%3BAcc:HGNC:18182]
ENSG00000185250	10.23	8.77	10.39	11.04	7.78	10.05	0.0426719193307141	3.45851102764862	0.789868122341108	0.950521861620957	6:109390214-109441171:-	PPIL6	4;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0006457,biological_process protein folding;GO:0016853,molecular_function isomerase activity	NA	peptidylprolyl isomerase like 6 [Source:HGNC Symbol%3BAcc:HGNC:21557]
ENSG00000148219	1.70	2.11	1.91	1.74	1.85	2.00	0.0342399458942164	3.07163139009024	0.790233612551855	0.950795941230181	9:116425224-117415070:-	ASTN2	18;GO:0005509,molecular_function calcium ion binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043204,cellular_component perikaryon;GO:0043533,molecular_function inositol 1,3,4,5 tetrakisphosphate binding;GO:0046872,molecular_function metal ion binding;GO:0048105,biological_process establishment of body hair planar orientation;GO:0060187,cellular_component cell pole;GO:2000009,biological_process negative regulation of protein localization to cell surface	NA	astrotactin 2 [Source:HGNC Symbol%3BAcc:HGNC:17021]
ENSG00000103591	26.38	23.87	25.86	24.56	26.48	27.09	-0.021822000324762	4.61467773774914	0.790268487741515	0.950795941230181	15:67201032-67255195:-	AAGAB	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016607,cellular_component nuclear speck	NA	alpha and gamma adaptin binding protein [Source:HGNC Symbol%3BAcc:HGNC:25662]
ENSG00000064932	21.81	19.36	21.19	21.72	20.41	21.60	-0.0172146654190262	6.47034479380288	0.790325668380972	0.950795941230181	19:1107635-1174283:-	SBNO2	18;GO:0001503,biological_process ossification;GO:0002281,biological_process macrophage activation involved in immune response;GO:0005575,cellular_component cellular_component;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0030282,biological_process bone mineralization;GO:0030316,biological_process osteoclast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050727,biological_process regulation of inflammatory response;GO:0061430,biological_process bone trabecula morphogenesis;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071348,biological_process cellular response to interleukin-11;GO:0071354,biological_process cellular response to interleukin-6;GO:0072674,biological_process multinuclear osteoclast differentiation;GO:0072675,biological_process osteoclast fusion;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	strawberry notch homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:29158]
ENSG00000001617	22.50	16.37	22.33	21.33	18.42	20.83	0.0314229157738503	5.6018778704263	0.790470174866788	0.950877631613668	3:50155044-50189075:+	SEMA3F	20;GO:0001755,biological_process neural crest cell migration;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007411,biological_process axon guidance;GO:0021612,biological_process facial nerve structural organization;GO:0021637,biological_process trigeminal nerve structural organization;GO:0021675,biological_process nerve development;GO:0021785,biological_process branchiomotor neuron axon guidance;GO:0036486,biological_process ventral trunk neural crest cell migration;GO:0038191,molecular_function neuropilin binding;GO:0045499,molecular_function chemorepellent activity;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0048846,biological_process axon extension involved in axon guidance;GO:0050919,biological_process negative chemotaxis;GO:0061549,biological_process sympathetic ganglion development;GO:0097490,biological_process sympathetic neuron projection extension;GO:0097491,biological_process sympathetic neuron projection guidance;GO:1901166,biological_process neural crest cell migration involved in autonomic nervous system development;GO:1902285,biological_process semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1902287,biological_process semaphorin-plexin signaling pathway involved in axon guidance	SEMA3; semaphorin 3; K06840	semaphorin 3F [Source:HGNC Symbol%3BAcc:HGNC:10728]
ENSG00000135924	47.59	47.69	46.43	49.43	46.81	48.41	-0.0186355515511715	5.61624769870074	0.790622848684593	0.950969129914909	2:219279266-219286900:+	DNAJB2	21;GO:0001671,molecular_function ATPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006986,biological_process response to unfolded protein;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0030544,molecular_function Hsp70 protein binding;GO:0031396,biological_process regulation of protein ubiquitination;GO:0032091,biological_process negative regulation of protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0042026,biological_process protein refolding;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0090084,biological_process negative regulation of inclusion body assembly;GO:1903644,biological_process regulation of chaperone-mediated protein folding	DNAJB2; DnaJ homolog subfamily B member 2; K09508	DnaJ heat shock protein family (Hsp40) member B2 [Source:HGNC Symbol%3BAcc:HGNC:5228]
ENSG00000170681	1.49	0.61	1.08	1.03	1.39	0.52	0.177572924643215	0.35483779383363	0.790918009506538	0.95121985929653	9:100578078-100587906:+	CAVIN4	17;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030154,biological_process cell differentiation;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042383,cellular_component sarcolemma;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	caveolae associated protein 4 [Source:HGNC Symbol%3BAcc:HGNC:33742]
ENSG00000146414	5.28	4.84	5.65	4.91	5.96	5.33	-0.0231596979841184	4.85948830494267	0.791011686390488	0.95121985929653	6:145864244-145964423:-	SHPRH	19;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006334,biological_process nucleosome assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	SNF2 histone linker PHD RING helicase [Source:HGNC Symbol%3BAcc:HGNC:19336]
ENSG00000204396	2.40	2.54	3.19	2.38	2.58	2.97	0.0490560595950782	2.87392147492739	0.791337108962538	0.95121985929653	6:31765589-31777294:-	VWA7	4;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005576,cellular_component extracellular region;GO:0008150,biological_process biological_process	NA	von Willebrand factor A domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:13939]
ENSG00000143353	39.04	40.32	40.27	42.65	34.13	41.64	0.0244824757988674	4.82658780053083	0.791352951274655	0.95121985929653	1:219173843-219212865:+	LYPLAL1	9;GO:0002084,biological_process protein depalmitoylation;GO:0004622,molecular_function lysophospholipase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008150,biological_process biological_process;GO:0008474,molecular_function palmitoyl-(protein) hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	lysophospholipase like 1 [Source:HGNC Symbol%3BAcc:HGNC:20440]
ENSG00000136457	2.23	2.31	2.26	1.74	2.61	2.15	0.0741079143628636	1.34135486000301	0.791523786797669	0.95121985929653	17:50464495-50468966:-	CHAD	9;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005737,cellular_component cytoplasm;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0060348,biological_process bone development;GO:1900155,biological_process negative regulation of bone trabecula formation	CHAD; chondroadherin; K06248	chondroadherin [Source:HGNC Symbol%3BAcc:HGNC:1909]
ENSG00000161956	10.76	8.74	9.21	9.94	8.91	9.56	0.0332801580291812	4.14611779315486	0.791531484466386	0.95121985929653	17:7561874-7571969:+	SENP3	14;GO:0004175,molecular_function endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0016926,biological_process protein desumoylation;GO:0016929,molecular_function SUMO-specific protease activity;GO:0071339,cellular_component MLL1 complex	NA	SUMO1/sentrin/SMT3 specific peptidase 3 [Source:HGNC Symbol%3BAcc:HGNC:17862]
ENSG00000135521	18.83	14.69	17.51	17.55	17.24	17.76	-0.0217450085130169	4.63538492139513	0.791551039486234	0.95121985929653	6:143843343-143863812:+	LTV1	10;GO:0000056,biological_process ribosomal small subunit export from nucleus;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0030688,cellular_component preribosome, small subunit precursor;GO:0031902,cellular_component late endosome membrane;GO:0034448,cellular_component EGO complex;GO:0042274,biological_process ribosomal small subunit biogenesis	NA	LTV1 ribosome biogenesis factor [Source:HGNC Symbol%3BAcc:HGNC:21173]
ENSG00000145555	28.28	28.10	27.10	29.37	26.75	29.04	-0.0171568998328913	7.46603281471539	0.791579678028858	0.95121985929653	5:16661913-16936276:-	MYO10	34;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016459,cellular_component myosin complex;GO:0022409,biological_process positive regulation of cell-cell adhesion;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0030507,molecular_function spectrin binding;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0031527,cellular_component filopodium membrane;GO:0032433,cellular_component filopodium tip;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0051015,molecular_function actin filament binding;GO:0051489,biological_process regulation of filopodium assembly;GO:0060002,molecular_function plus-end directed microfilament motor activity	MYO10; myosin X; K12559	myosin X [Source:HGNC Symbol%3BAcc:HGNC:7593]
ENSG00000167747	57.55	46.83	50.95	58.23	48.62	53.49	-0.0271108301952712	4.22381798244449	0.791592689127759	0.95121985929653	19:50797703-50804929:-	C19orf48	NA	NA	chromosome 19 open reading frame 48 [Source:HGNC Symbol%3BAcc:HGNC:29667]
ENSG00000143322	4.95	4.37	5.70	5.57	4.00	5.21	0.0384808297981193	4.2157712696895	0.791701283770001	0.95121985929653	1:179099326-179229684:-	ABL2	40;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001784,molecular_function phosphotyrosine binding;GO:0003785,molecular_function actin monomer binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0010506,biological_process regulation of autophagy;GO:0010863,biological_process positive regulation of phospholipase C activity;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015629,cellular_component actin cytoskeleton;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030100,biological_process regulation of endocytosis;GO:0030145,molecular_function manganese ion binding;GO:0030155,biological_process regulation of cell adhesion;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0051353,biological_process positive regulation of oxidoreductase activity;GO:0071300,biological_process cellular response to retinoic acid;GO:2000145,biological_process regulation of cell motility;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]; K08887	ABL proto-oncogene 2%2C non-receptor tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:77]
ENSG00000105643	7.87	6.55	7.56	8.21	6.38	8.19	-0.032845505043503	3.60736558786094	0.791734489205042	0.95121985929653	19:18001131-18014102:+	ARRDC2	2;GO:0005886,cellular_component plasma membrane;GO:0031410,cellular_component cytoplasmic vesicle	NA	arrestin domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25225]
ENSG00000166233	20.15	18.57	19.71	19.54	17.70	20.82	0.0229193225927272	5.11177248411121	0.791763850867441	0.95121985929653	15:72474325-72602985:+	ARIH1	25;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015030,cellular_component Cajal body;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0031462,cellular_component Cul2-RING ubiquitin ligase complex;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0031464,cellular_component Cul4A-RING E3 ubiquitin ligase complex;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0097413,cellular_component Lewy body	NA	ariadne RBR E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:689]
ENSG00000139697	11.19	11.82	11.94	10.93	12.38	11.44	0.0193372502490034	5.60600440734775	0.791853598364167	0.95121985929653	12:123289108-123364843:-	SBNO1	4;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process	NA	strawberry notch homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:22973]
ENSG00000143862	51.13	44.01	52.50	52.73	48.12	45.74	0.0291723747641167	4.7857891042033	0.791904399145913	0.95121985929653	1:202133403-202144743:-	ARL8A	24;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0030496,cellular_component midbody;GO:0031902,cellular_component late endosome membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0043014,molecular_function alpha-tubulin binding;GO:0043312,biological_process neutrophil degranulation;GO:0048487,molecular_function beta-tubulin binding;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	ADP ribosylation factor like GTPase 8A [Source:HGNC Symbol%3BAcc:HGNC:25192]
ENSG00000092208	20.89	21.61	21.53	20.55	20.73	22.15	0.0226937250208429	4.25112104535873	0.791980765796313	0.95121985929653	14:39114222-39136973:+	GEMIN2	18;GO:0000245,biological_process spliceosomal complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0097504,cellular_component Gemini of coiled bodies	GEMIN2, SIP1; gem associated protein 2; K13130	gem nuclear organelle associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:10884]
ENSG00000165689	31.48	29.78	32.42	33.23	29.77	32.82	-0.0187227878595776	5.59287669430124	0.792107649087676	0.951280209764447	9:136401921-136410609:-	SDCCAG3	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0015031,biological_process protein transport;GO:0030496,cellular_component midbody;GO:0030904,cellular_component retromer complex;GO:0032465,biological_process regulation of cytokinesis;GO:0051301,biological_process cell division;GO:0055037,cellular_component recycling endosome;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	serologically defined colon cancer antigen 3 [Source:HGNC Symbol%3BAcc:HGNC:10667]
ENSG00000136897	44.10	52.42	43.17	43.12	55.36	45.25	-0.0350397113393835	4.49071227666033	0.792213248513645	0.951314990209914	9:101387632-101398614:-	MRPL50	7;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L50 [Source:HGNC Symbol%3BAcc:HGNC:16654]
ENSG00000116288	392.93	429.89	363.70	385.75	408.13	386.40	0.0184379110836475	7.88331752428473	0.792406418538294	0.951454911328675	1:7954290-7985505:+	PARK7	141;GO:0000785,cellular_component chromatin;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001963,biological_process synaptic transmission, dopaminergic;GO:0002866,biological_process positive regulation of acute inflammatory response to antigenic stimulus;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005102,molecular_function receptor binding;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006508,biological_process proteolysis;GO:0006517,biological_process protein deglycosylation;GO:0006914,biological_process autophagy;GO:0006954,biological_process inflammatory response;GO:0007005,biological_process mitochondrion organization;GO:0007265,biological_process Ras protein signal transduction;GO:0007338,biological_process single fertilization;GO:0008134,molecular_function transcription factor binding;GO:0008233,molecular_function peptidase activity;GO:0008344,biological_process adult locomotory behavior;GO:0009438,biological_process methylglyoxal metabolic process;GO:0010273,biological_process detoxification of copper ion;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016532,molecular_function superoxide dismutase copper chaperone activity;GO:0016605,cellular_component PML body;GO:0016684,molecular_function oxidoreductase activity, acting on peroxide as acceptor;GO:0016787,molecular_function hydrolase activity;GO:0018323,biological_process enzyme active site formation via L-cysteine sulfinic acid;GO:0019249,biological_process lactate biosynthetic process;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0019955,molecular_function cytokine binding;GO:0030424,cellular_component axon;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032091,biological_process negative regulation of protein binding;GO:0032148,biological_process activation of protein kinase B activity;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0033864,biological_process positive regulation of NAD(P)H oxidase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0036470,molecular_function tyrosine 3-monooxygenase activator activity;GO:0036471,biological_process cellular response to glyoxal;GO:0036478,molecular_function L-dopa decarboxylase activator activity;GO:0036524,molecular_function protein deglycase activity;GO:0036526,biological_process peptidyl-cysteine deglycation;GO:0036527,biological_process peptidyl-arginine deglycation;GO:0036528,biological_process peptidyl-lysine deglycation;GO:0036529,biological_process protein deglycation, glyoxal removal;GO:0036530,biological_process protein deglycation, methylglyoxal removal;GO:0036531,biological_process glutathione deglycation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042542,biological_process response to hydrogen peroxide;GO:0042743,biological_process hydrogen peroxide metabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044297,cellular_component cell body;GO:0044388,molecular_function small protein activating enzyme binding;GO:0044390,molecular_function ubiquitin-like protein conjugating enzyme binding;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0045340,molecular_function mercury ion binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046295,biological_process glycolate biosynthetic process;GO:0046826,biological_process negative regulation of protein export from nucleus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050681,molecular_function androgen receptor binding;GO:0050727,biological_process regulation of inflammatory response;GO:0050787,biological_process detoxification of mercury ion;GO:0050821,biological_process protein stabilization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051444,biological_process negative regulation of ubiquitin-protein transferase activity;GO:0051583,biological_process dopamine uptake involved in synaptic transmission;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0051899,biological_process membrane depolarization;GO:0051920,molecular_function peroxiredoxin activity;GO:0060081,biological_process membrane hyperpolarization;GO:0060548,biological_process negative regulation of cell death;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070491,molecular_function repressing transcription factor binding;GO:0090073,biological_process positive regulation of protein homodimerization activity;GO:0097110,molecular_function scaffold protein binding;GO:0098793,cellular_component presynapse;GO:0098869,biological_process cellular oxidant detoxification;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901215,biological_process negative regulation of neuron death;GO:1901671,biological_process positive regulation of superoxide dismutase activity;GO:1901984,biological_process negative regulation of protein acetylation;GO:1902177,biological_process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902903,biological_process regulation of fibril organization;GO:1902958,biological_process positive regulation of mitochondrial electron transport, NADH to ubiquinone;GO:1903073,biological_process negative regulation of death-inducing signaling complex assembly;GO:1903094,biological_process negative regulation of protein K48-linked deubiquitination;GO:1903122,biological_process negative regulation of TRAIL-activated apoptotic signaling pathway;GO:1903135,molecular_function cupric ion binding;GO:1903136,molecular_function cuprous ion binding;GO:1903168,biological_process positive regulation of pyrroline-5-carboxylate reductase activity;GO:1903178,biological_process positive regulation of tyrosine 3-monooxygenase activity;GO:1903181,biological_process positive regulation of dopamine biosynthetic process;GO:1903189,biological_process glyoxal metabolic process;GO:1903197,biological_process positive regulation of L-dopa biosynthetic process;GO:1903200,biological_process positive regulation of L-dopa decarboxylase activity;GO:1903202,biological_process negative regulation of oxidative stress-induced cell death;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death;GO:1903208,biological_process negative regulation of hydrogen peroxide-induced neuron death;GO:1903377,biological_process negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903384,biological_process negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway;GO:1903428,biological_process positive regulation of reactive oxygen species biosynthetic process;GO:1903599,biological_process positive regulation of mitophagy;GO:1905259,biological_process negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;GO:1990381,molecular_function ubiquitin-specific protease binding;GO:2000157,biological_process negative regulation of ubiquitin-specific protease activity;GO:2000277,biological_process positive regulation of oxidative phosphorylation uncoupler activity;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding;GO:2000825,biological_process positive regulation of androgen receptor activity;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway;GO:2001268,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	NA	Parkinsonism associated deglycase [Source:HGNC Symbol%3BAcc:HGNC:16369]
ENSG00000132906	10.22	10.38	11.19	10.17	11.97	10.58	-0.0282986473507281	3.88830705043738	0.792645851132193	0.951593010039547	1:15490831-15526534:-	CASP9	40;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007568,biological_process aging;GO:0008047,molecular_function enzyme activator activity;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0009411,biological_process response to UV;GO:0014070,biological_process response to organic cyclic compound;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0019901,molecular_function protein kinase binding;GO:0030220,biological_process platelet formation;GO:0032025,biological_process response to cobalt ion;GO:0032355,biological_process response to estradiol;GO:0032496,biological_process response to lipopolysaccharide;GO:0034349,biological_process glial cell apoptotic process;GO:0034644,biological_process cellular response to UV;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043293,cellular_component apoptosome;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0046677,biological_process response to antibiotic;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:0097194,biological_process execution phase of apoptosis;GO:0097200,molecular_function cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:2001020,biological_process regulation of response to DNA damage stimulus	CASP9; caspase 9 [EC:3.4.22.62]; K04399	caspase 9 [Source:HGNC Symbol%3BAcc:HGNC:1511]
ENSG00000162377	15.90	14.20	15.40	17.18	16.74	13.19	-0.03064843396608	3.44183846779101	0.792727051108392	0.951593010039547	1:52684450-52698366:-	COA7	3;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space	NA	cytochrome c oxidase assembly factor 7 (putative) [Source:HGNC Symbol%3BAcc:HGNC:25716]
ENSG00000127022	318.09	322.14	322.94	321.01	325.06	335.08	-0.0148882009195244	9.30850842546443	0.792751415195275	0.951593010039547	5:179678627-179730925:+	CANX	38;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005840,cellular_component ribosome;GO:0006457,biological_process protein folding;GO:0007568,biological_process aging;GO:0009306,biological_process protein secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030246,molecular_function carbohydrate binding;GO:0030424,cellular_component axon;GO:0031012,cellular_component extracellular matrix;GO:0032839,cellular_component dendrite cytoplasm;GO:0034185,molecular_function apolipoprotein binding;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0042470,cellular_component melanosome;GO:0043025,cellular_component neuronal cell body;GO:0043197,cellular_component dendritic spine;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0046872,molecular_function metal ion binding;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0071556,cellular_component integral component of lumenal side of endoplasmic reticulum membrane;GO:0072583,biological_process clathrin-mediated endocytosis	CANX; calnexin; K08054	calnexin [Source:HGNC Symbol%3BAcc:HGNC:1473]
ENSG00000164904	54.82	56.21	51.78	52.95	57.59	55.58	-0.0182970027948433	6.70453397848387	0.792975586293263	0.951770059239825	5:126531199-126595418:-	ALDH7A1	18;GO:0004029,molecular_function aldehyde dehydrogenase (NAD) activity;GO:0004043,molecular_function L-aminoadipate-semialdehyde dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006081,biological_process cellular aldehyde metabolic process;GO:0006554,biological_process lysine catabolic process;GO:0007605,biological_process sensory perception of sound;GO:0008152,biological_process metabolic process;GO:0008802,molecular_function betaine-aldehyde dehydrogenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019285,biological_process glycine betaine biosynthetic process from choline;GO:0042426,biological_process choline catabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]; K14085	aldehyde dehydrogenase 7 family member A1 [Source:HGNC Symbol%3BAcc:HGNC:877]
ENSG00000083093	8.56	8.47	9.01	8.60	8.57	9.48	-0.0214575842847159	4.99613566380202	0.79311738338961	0.951848214252657	16:23603159-23641310:-	PALB2	19;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0001701,biological_process in utero embryonic development;GO:0001756,biological_process somitogenesis;GO:0001833,biological_process inner cell mass cell proliferation;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007498,biological_process mesoderm development;GO:0009887,biological_process organ morphogenesis;GO:0035264,biological_process multicellular organism growth;GO:0036342,biological_process post-anal tail morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0048568,biological_process embryonic organ development	PALB2, FANCN; partner and localizer of BRCA2; K10897	partner and localizer of BRCA2 [Source:HGNC Symbol%3BAcc:HGNC:26144]
ENSG00000197757	11.90	9.29	8.07	9.13	9.77	9.73	0.0490786383043804	2.85106608040589	0.793243246118796	0.951907232605628	12:53990623-54030823:+	HOXC6	14;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048706,biological_process embryonic skeletal system development;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	homeobox C6 [Source:HGNC Symbol%3BAcc:HGNC:5128]
ENSG00000128578	11.90	13.64	12.75	13.69	12.60	12.85	-0.0247587461721395	5.03013197604775	0.793333782497252	0.951908663339561	7:129434432-129488399:+	STRIP2	6;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0016477,biological_process cell migration	NA	striatin interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:22209]
ENSG00000111252	9.18	7.07	8.82	9.28	7.31	8.18	0.0386878103104967	4.04591125726413	0.793397811239112	0.951908663339561	12:111405947-111451623:+	SH2B3	11;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0007596,biological_process blood coagulation;GO:0009967,biological_process positive regulation of signal transduction;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0035162,biological_process embryonic hemopoiesis;GO:0035556,biological_process intracellular signal transduction;GO:0035591,molecular_function signaling adaptor activity	SH2B1_3; SH2B adaptor protein 1/3; K12459	SH2B adaptor protein 3 [Source:HGNC Symbol%3BAcc:HGNC:29605]
ENSG00000103197	18.72	16.51	19.13	19.10	18.01	18.45	-0.017547748183967	6.71703269526798	0.793562041067365	0.95201368665016	16:2047464-2088720:+	TSC2	40;GO:0001843,biological_process neural tube closure;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006606,biological_process protein import into nucleus;GO:0006897,biological_process endocytosis;GO:0007050,biological_process cell cycle arrest;GO:0007507,biological_process heart development;GO:0008104,biological_process protein localization;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016192,biological_process vesicle-mediated transport;GO:0016239,biological_process positive regulation of macroautophagy;GO:0019902,molecular_function phosphatase binding;GO:0030100,biological_process regulation of endocytosis;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0031267,molecular_function small GTPase binding;GO:0032007,biological_process negative regulation of TOR signaling;GO:0033596,cellular_component TSC1-TSC2 complex;GO:0042803,molecular_function protein homodimerization activity;GO:0043276,biological_process anoikis;GO:0043491,biological_process protein kinase B signaling;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050918,biological_process positive chemotaxis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051726,biological_process regulation of cell cycle;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0061024,biological_process membrane organization;GO:1901525,biological_process negative regulation of macromitophagy	TSC2; tuberous sclerosis 2; K07207	tuberous sclerosis 2 [Source:HGNC Symbol%3BAcc:HGNC:12363]
ENSG00000128891	6.90	6.49	7.11	6.34	6.60	7.12	0.0464988912660389	2.54529578730375	0.793770133163666	0.952103856323231	15:40528682-40565057:-	CCDC32	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 32 [Source:HGNC Symbol%3BAcc:HGNC:28295]
ENSG00000171219	0.33	0.29	0.32	0.23	0.36	0.30	0.102623733479736	0.651254834510998	0.793906730394053	0.952103856323231	11:64823386-64844569:-	CDC42BPG	17;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031252,cellular_component cell leading edge;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	CDC42 binding protein kinase gamma [Source:HGNC Symbol%3BAcc:HGNC:29829]
ENSG00000156711	3.74	2.09	2.89	3.28	2.08	3.91	-0.0608645765730938	1.8029884775654	0.793929836286503	0.952103856323231	6:36127808-36144524:+	MAPK13	26;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004707,molecular_function MAP kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006950,biological_process response to stress;GO:0006970,biological_process response to osmotic stress;GO:0007049,biological_process cell cycle;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0035556,biological_process intracellular signal transduction;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0050729,biological_process positive regulation of inflammatory response	P38; p38 MAP kinase [EC:2.7.11.24]; K04441	mitogen-activated protein kinase 13 [Source:HGNC Symbol%3BAcc:HGNC:6875]
ENSG00000175768	12.27	23.02	16.16	16.44	17.57	15.44	0.0474065146842471	2.48282566765403	0.794002735747243	0.952103856323231	9:37582645-37592642:-	TOMM5	10;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy	NA	translocase of outer mitochondrial membrane 5 [Source:HGNC Symbol%3BAcc:HGNC:31369]
ENSG00000138738	1.66	1.71	1.69	1.37	1.74	2.19	-0.0644906573588935	1.82595484055866	0.79402071382084	0.952103856323231	4:120684918-120922870:-	PRDM5	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000278,biological_process mitotic cell cycle;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051567,biological_process histone H3-K9 methylation;GO:0070491,molecular_function repressing transcription factor binding;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	PR/SET domain 5 [Source:HGNC Symbol%3BAcc:HGNC:9349]
ENSG00000221829	12.60	12.75	12.54	11.96	12.27	13.34	0.0220798424694151	4.56291507326075	0.794267346663227	0.952307599162623	9:35073834-35080016:-	FANCG	18;GO:0000075,biological_process cell cycle checkpoint;GO:0001541,biological_process ovarian follicle development;GO:0003684,molecular_function damaged DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007005,biological_process mitochondrion organization;GO:0007286,biological_process spermatid development;GO:0009314,biological_process response to radiation;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex	FANCG; fanconi anemia group G protein; K10894	Fanconi anemia complementation group G [Source:HGNC Symbol%3BAcc:HGNC:3588]
ENSG00000137876	193.27	184.79	208.86	206.71	177.76	216.11	-0.0206621280768343	6.8290302702997	0.79462523879985	0.952440852276078	15:55180805-55197067:-	RSL24D1	12;GO:0000027,biological_process ribosomal large subunit assembly;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0042254,biological_process ribosome biogenesis;GO:1902626,biological_process assembly of large subunit precursor of preribosome	RP-L24e, RPL24; large subunit ribosomal protein L24e; K02896	ribosomal L24 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18479]
ENSG00000167797	64.21	56.47	52.62	56.15	56.41	65.38	-0.0256608352470286	4.83492521082503	0.794671690155044	0.952440852276078	11:67506496-67508649:-	CDK2AP2	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005874,cellular_component microtubule;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:2000035,biological_process regulation of stem cell division;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	cyclin dependent kinase 2 associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:30833]
ENSG00000102317	259.38	257.39	243.70	260.11	258.88	256.17	-0.0161216831636342	7.43471135359971	0.794856580867338	0.952440852276078	X:48574448-48579066:+	RBM3	13;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006417,biological_process regulation of translation;GO:0015934,cellular_component large ribosomal subunit;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0045727,biological_process positive regulation of translation	NA	RNA binding motif (RNP1%2C RRM) protein 3 [Source:HGNC Symbol%3BAcc:HGNC:9900]
ENSG00000169562	1.41	1.80	1.65	1.59	2.05	0.91	0.103985823085729	0.556091098468277	0.794868408200827	0.952440852276078	X:71215193-71225516:+	GJB1	21;GO:0005243,molecular_function gap junction channel activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005921,cellular_component gap junction;GO:0005922,cellular_component connexon complex;GO:0006810,biological_process transport;GO:0007154,biological_process cell communication;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0015868,biological_process purine ribonucleotide transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016264,biological_process gap junction assembly;GO:0016328,cellular_component lateral plasma membrane;GO:0030054,cellular_component cell junction;GO:0042803,molecular_function protein homodimerization activity;GO:0051259,biological_process protein oligomerization;GO:0055085,biological_process transmembrane transport;GO:1905867,biological_process epididymis development	NA	gap junction protein beta 1 [Source:HGNC Symbol%3BAcc:HGNC:4283]
ENSG00000198863	8.30	7.90	8.04	8.02	8.00	7.95	0.0300512556513522	3.90154744133194	0.794910823908661	0.952440852276078	17:42980564-42993690:+	RUNDC1	7;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	RUN domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25418]
ENSG00000141867	21.32	19.63	22.13	22.41	20.22	21.84	-0.0178543108267271	6.52968687417555	0.794912162567075	0.952440852276078	19:15235518-15332545:-	BRD4	22;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000993,molecular_function RNA polymerase II core binding;GO:0002039,molecular_function p53 binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010971,biological_process positive regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050727,biological_process regulation of inflammatory response;GO:0070577,molecular_function lysine-acetylated histone binding;GO:1901407,biological_process regulation of phosphorylation of RNA polymerase II C-terminal domain	NA	bromodomain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:13575]
ENSG00000101452	5.21	5.03	5.88	5.66	6.06	4.95	-0.0308536528878215	3.56116780558702	0.794915590878931	0.952440852276078	20:38962298-39039723:+	DHX35	13;GO:0000166,molecular_function nucleotide binding;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016787,molecular_function hydrolase activity;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	DEAH-box helicase 35 [Source:HGNC Symbol%3BAcc:HGNC:15861]
ENSG00000181026	2.25	2.84	2.72	2.38	2.88	2.24	0.0618217219153787	1.39161689286387	0.795165510441432	0.952542084624403	15:88621295-88632282:+	AEN	14;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010212,biological_process response to ionizing radiation;GO:0016787,molecular_function hydrolase activity;GO:0031965,cellular_component nuclear membrane;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	apoptosis enhancing nuclease [Source:HGNC Symbol%3BAcc:HGNC:25722]
ENSG00000161013	185.93	189.10	187.29	176.34	197.04	187.22	0.0161907710259049	8.45878003443339	0.795320861481196	0.952542084624403	5:179797596-179806952:-	MGAT4B	14;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006491,biological_process N-glycan processing;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0008454,molecular_function alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0046872,molecular_function metal ion binding	MGAT4A_B; alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]; K00738	mannosyl (alpha-1%2C3-)-glycoprotein beta-1%2C4-N-acetylglucosaminyltransferase%2C isozyme B [Source:HGNC Symbol%3BAcc:HGNC:7048]
ENSG00000117481	4.90	4.72	5.04	4.65	5.21	4.66	0.0282164483867455	4.0201929261299	0.795480863815392	0.952542084624403	1:46340176-46365152:+	NSUN4	16;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0009383,molecular_function rRNA (cytosine-C5-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0019843,molecular_function rRNA binding;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0042254,biological_process ribosome biogenesis;GO:0042256,biological_process mature ribosome assembly;GO:0070131,biological_process positive regulation of mitochondrial translation;GO:0070181,molecular_function small ribosomal subunit rRNA binding	NA	NOP2/Sun RNA methyltransferase family member 4 [Source:HGNC Symbol%3BAcc:HGNC:31802]
ENSG00000188612	560.30	626.04	552.65	595.04	592.90	585.98	-0.0184417424445921	7.38411699194315	0.795490106442943	0.952542084624403	17:75165585-75182983:-	SUMO2	13;GO:0001222,molecular_function transcription corepressor binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016605,cellular_component PML body;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0031386,molecular_function protein tag;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070911,biological_process global genome nucleotide-excision repair	SUMO, SMT3; small ubiquitin-related modifier; K12160	small ubiquitin-like modifier 2 [Source:HGNC Symbol%3BAcc:HGNC:11125]
ENSG00000164258	32.19	30.74	33.54	34.02	31.82	33.09	-0.021232969649911	4.61408083535478	0.795498950787096	0.952542084624403	5:53560632-53683340:+	NDUFS4	19;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0007420,biological_process brain development;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0019933,biological_process cAMP-mediated signaling;GO:0022900,biological_process electron transport chain;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0045271,cellular_component respiratory chain complex I;GO:0045333,biological_process cellular respiration;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051591,biological_process response to cAMP;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:0072593,biological_process reactive oxygen species metabolic process	NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4; K03937	NADH:ubiquinone oxidoreductase subunit S4 [Source:HGNC Symbol%3BAcc:HGNC:7711]
ENSG00000100242	48.12	45.24	46.92	49.49	45.30	48.36	-0.016683453314964	6.86553891820193	0.79551406330261	0.952542084624403	22:38734724-38794143:-	SUN2	27;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000794,cellular_component condensed nuclear chromosome;GO:0005515,molecular_function protein binding;GO:0005521,molecular_function lamin binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0005768,cellular_component endosome;GO:0006998,biological_process nuclear envelope organization;GO:0007052,biological_process mitotic spindle organization;GO:0007097,biological_process nuclear migration;GO:0008017,molecular_function microtubule binding;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021817,biological_process nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0030335,biological_process positive regulation of cell migration;GO:0031022,biological_process nuclear migration along microfilament;GO:0031965,cellular_component nuclear membrane;GO:0034993,cellular_component LINC complex;GO:0042802,molecular_function identical protein binding;GO:0043495,molecular_function protein anchor;GO:0051321,biological_process meiotic cell cycle;GO:0051642,biological_process centrosome localization;GO:0090286,biological_process cytoskeletal anchoring at nuclear membrane;GO:0090292,biological_process nuclear matrix anchoring at nuclear membrane	NA	Sad1 and UNC84 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:14210]
ENSG00000076944	25.55	23.74	24.73	23.15	24.78	25.82	0.0183978627697263	6.1698723532759	0.795683897182264	0.952542084624403	19:7636880-7647873:+	STXBP2	25;GO:0001909,biological_process leukocyte mediated cytotoxicity;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016324,cellular_component apical plasma membrane;GO:0017075,molecular_function syntaxin-1 binding;GO:0030348,molecular_function syntaxin-3 binding;GO:0031201,cellular_component SNARE complex;GO:0042581,cellular_component specific granule;GO:0042582,cellular_component azurophil granule;GO:0042589,cellular_component zymogen granule membrane;GO:0043304,biological_process regulation of mast cell degranulation;GO:0043312,biological_process neutrophil degranulation;GO:0044194,cellular_component cytolytic granule;GO:0070062,cellular_component extracellular exosome;GO:0070820,cellular_component tertiary granule	NA	syntaxin binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11445]
ENSG00000163794	4.37	3.60	3.56	3.22	2.85	4.91	0.0788968846015642	0.639175712069748	0.795707218814347	0.952542084624403	2:27307399-27308445:-	UCN	64;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001964,biological_process startle response;GO:0005179,molecular_function hormone activity;GO:0005184,molecular_function neuropeptide hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0006954,biological_process inflammatory response;GO:0006979,biological_process response to oxidative stress;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007218,biological_process neuropeptide signaling pathway;GO:0007565,biological_process female pregnancy;GO:0007605,biological_process sensory perception of sound;GO:0007611,biological_process learning or memory;GO:0007631,biological_process feeding behavior;GO:0008306,biological_process associative learning;GO:0009060,biological_process aerobic respiration;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010996,biological_process response to auditory stimulus;GO:0030157,biological_process pancreatic juice secretion;GO:0030307,biological_process positive regulation of cell growth;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0031064,biological_process negative regulation of histone deacetylation;GO:0031175,biological_process neuron projection development;GO:0032099,biological_process negative regulation of appetite;GO:0032355,biological_process response to estradiol;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034199,biological_process activation of protein kinase A activity;GO:0035176,biological_process social behavior;GO:0035483,biological_process gastric emptying;GO:0042756,biological_process drinking behavior;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043117,biological_process positive regulation of vascular permeability;GO:0043196,cellular_component varicosity;GO:0043204,cellular_component perikaryon;GO:0043679,cellular_component axon terminus;GO:0045727,biological_process positive regulation of translation;GO:0045740,biological_process positive regulation of DNA replication;GO:0045776,biological_process negative regulation of blood pressure;GO:0045792,biological_process negative regulation of cell size;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046811,molecular_function histone deacetylase inhibitor activity;GO:0046888,biological_process negative regulation of hormone secretion;GO:0048265,biological_process response to pain;GO:0051384,biological_process response to glucocorticoid;GO:0051430,molecular_function corticotropin-releasing hormone receptor 1 binding;GO:0051431,molecular_function corticotropin-releasing hormone receptor 2 binding;GO:0051461,biological_process positive regulation of corticotropin secretion;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0060452,biological_process positive regulation of cardiac muscle contraction;GO:0060455,biological_process negative regulation of gastric acid secretion;GO:0060547,biological_process negative regulation of necrotic cell death;GO:0060548,biological_process negative regulation of cell death;GO:0090280,biological_process positive regulation of calcium ion import;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1901215,biological_process negative regulation of neuron death;GO:2000252,biological_process negative regulation of feeding behavior;GO:2000987,biological_process positive regulation of behavioral fear response	NA	urocortin [Source:HGNC Symbol%3BAcc:HGNC:12516]
ENSG00000152558	242.39	236.80	233.84	228.16	265.85	234.14	-0.0182951789325716	7.29995109384457	0.795744061500479	0.952542084624403	11:102396331-102470384:-	TMEM123	7;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0070267,biological_process oncosis	NA	transmembrane protein 123 [Source:HGNC Symbol%3BAcc:HGNC:30138]
ENSG00000272333	7.12	7.15	7.56	7.67	7.24	6.82	0.0192877109850712	5.89048051705226	0.795825586613369	0.952542084624403	19:35718018-35738878:+	KMT2B	27;GO:0001541,biological_process ovarian follicle development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007613,biological_process memory;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0009994,biological_process oocyte differentiation;GO:0016458,biological_process gene silencing;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030728,biological_process ovulation;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0051568,biological_process histone H3-K4 methylation;GO:0051569,biological_process regulation of histone H3-K4 methylation;GO:0080182,biological_process histone H3-K4 trimethylation	MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]; K14959	lysine methyltransferase 2B [Source:HGNC Symbol%3BAcc:HGNC:15840]
ENSG00000109743	3.98	2.78	3.61	4.76	3.03	3.19	-0.0549788999674791	2.03574176252014	0.796098185198116	0.952542084624403	4:15702949-15738313:+	BST1	33;GO:0001931,cellular_component uropod;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0002691,biological_process regulation of cellular extravasation;GO:0003953,molecular_function NAD+ nucleosidase activity;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0006959,biological_process humoral immune response;GO:0007165,biological_process signal transduction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008305,cellular_component integrin complex;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0019674,biological_process NAD metabolic process;GO:0019898,cellular_component extrinsic component of membrane;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031225,cellular_component anchored component of membrane;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0050135,molecular_function NAD(P)+ nucleosidase activity;GO:0050727,biological_process regulation of inflammatory response;GO:0050730,biological_process regulation of peptidyl-tyrosine phosphorylation;GO:0050848,biological_process regulation of calcium-mediated signaling;GO:0061809,molecular_function NAD+ nucleotidase, cyclic ADP-ribose generating;GO:0061811,molecular_function ADP-ribosyl cyclase activity;GO:0061812,molecular_function cyclic ADP-ribose hydrolase;GO:0070062,cellular_component extracellular exosome;GO:0090022,biological_process regulation of neutrophil chemotaxis;GO:0090322,biological_process regulation of superoxide metabolic process;GO:2001044,biological_process regulation of integrin-mediated signaling pathway	CD38; ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]; K01242	bone marrow stromal cell antigen 1 [Source:HGNC Symbol%3BAcc:HGNC:1118]
ENSG00000116984	11.11	11.16	10.90	10.79	11.21	11.01	0.0179143062042682	5.39311804875863	0.79613834307325	0.952542084624403	1:236795280-236903981:+	MTR	20;GO:0000096,biological_process sulfur amino acid metabolic process;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007399,biological_process nervous system development;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0008705,molecular_function methionine synthase activity;GO:0009086,biological_process methionine biosynthetic process;GO:0009235,biological_process cobalamin metabolic process;GO:0016740,molecular_function transferase activity;GO:0031103,biological_process axon regeneration;GO:0031419,molecular_function cobalamin binding;GO:0032259,biological_process methylation;GO:0042558,biological_process pteridine-containing compound metabolic process;GO:0044237,biological_process cellular metabolic process;GO:0046872,molecular_function metal ion binding;GO:0048678,biological_process response to axon injury;GO:0071732,biological_process cellular response to nitric oxide	metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]; K00548	5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:7468]
ENSG00000187109	411.10	391.95	395.03	396.68	385.78	412.88	0.0152240061844741	9.20586522827875	0.796155810924659	0.952542084624403	12:76036586-76085033:-	NAP1L1	8;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0006334,biological_process nucleosome assembly;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0042470,cellular_component melanosome	NA	nucleosome assembly protein 1 like 1 [Source:HGNC Symbol%3BAcc:HGNC:7637]
ENSG00000083812	2.13	2.48	2.35	2.30	2.70	2.25	-0.0528604622175454	2.02440063152085	0.796167847312312	0.952542084624403	19:58467044-58475436:+	ZNF324	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 324 [Source:HGNC Symbol%3BAcc:HGNC:14096]
ENSG00000184924	36.99	40.05	44.16	40.29	40.63	43.53	-0.0277755784716852	4.11798880738862	0.796174054932695	0.952542084624403	2:24789733-24793382:-	PTRHD1	3;GO:0004045,molecular_function aminoacyl-tRNA hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	peptidyl-tRNA hydrolase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:33782]
ENSG00000158417	71.05	75.26	71.21	70.46	76.40	69.90	0.0163976042931982	8.05328026505099	0.796268090597648	0.952542084624403	2:99337352-99401326:+	EIF5B	13;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	EIF5B; translation initiation factor 5B; K03243	eukaryotic translation initiation factor 5B [Source:HGNC Symbol%3BAcc:HGNC:30793]
ENSG00000129219	11.44	12.22	11.64	11.45	12.07	11.54	0.0186780192646125	5.06325508656072	0.796304617106858	0.952542084624403	17:4807095-4823434:+	PLD2	19;GO:0003824,molecular_function catalytic activity;GO:0004630,molecular_function phospholipase D activity;GO:0005515,molecular_function protein binding;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0007010,biological_process cytoskeleton organization;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036465,biological_process synaptic vesicle recycling;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048870,biological_process cell motility;GO:0070290,molecular_function N-acylphosphatidylethanolamine-specific phospholipase D activity;GO:0098793,cellular_component presynapse	PLD1_2; phospholipase D1/2 [EC:3.1.4.4]; K01115	phospholipase D2 [Source:HGNC Symbol%3BAcc:HGNC:9068]
ENSG00000140474	6.06	6.21	6.22	5.57	6.22	6.39	0.033815640535228	3.29912119288349	0.796660739585406	0.952795806347742	15:74836115-74843346:-	ULK3	17;GO:0000166,molecular_function nucleotide binding;GO:0000407,cellular_component pre-autophagosomal structure;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006914,biological_process autophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0046777,biological_process protein autophosphorylation;GO:0090398,biological_process cellular senescence;GO:0097542,cellular_component ciliary tip	ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]; K08269	unc-51 like kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:19703]
ENSG00000141002	55.72	54.80	55.70	55.37	56.68	57.37	-0.01559013263985	7.16058450150436	0.796670238788626	0.952795806347742	16:89873569-89913627:+	TCF25	8;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007507,biological_process heart development	NA	transcription factor 25 [Source:HGNC Symbol%3BAcc:HGNC:29181]
ENSG00000123091	77.05	74.26	75.03	74.06	73.38	77.78	0.0195551762297535	5.12748598159769	0.796874691962042	0.952813670125891	1:51236270-51273455:+	RNF11	17;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008270,molecular_function zinc ion binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination;GO:0055037,cellular_component recycling endosome;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome	NA	ring finger protein 11 [Source:HGNC Symbol%3BAcc:HGNC:10056]
ENSG00000119608	0.68	0.97	0.79	0.55	1.02	0.67	0.108259823528944	0.604999121609752	0.796932229197573	0.952813670125891	14:74852870-74871940:-	PROX2	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001946,biological_process lymphangiogenesis;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030182,biological_process neuron differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060836,biological_process lymphatic endothelial cell differentiation;GO:0070309,biological_process lens fiber cell morphogenesis	NA	prospero homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:26715]
ENSG00000174891	21.49	22.73	20.96	19.34	24.05	23.44	-0.0275292669277699	4.69804558826712	0.797066047912934	0.952813670125891	3:158105854-158545730:+	RSRC1	11;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0006913,biological_process nucleocytoplasmic transport;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0046677,biological_process response to antibiotic	NA	arginine and serine rich coiled-coil 1 [Source:HGNC Symbol%3BAcc:HGNC:24152]
ENSG00000087053	30.53	31.61	30.49	29.34	31.02	31.86	0.0162615692302841	5.89724219983826	0.797247643858721	0.952813670125891	11:95832881-95925315:-	MTMR2	42;GO:0002091,biological_process negative regulation of receptor internalization;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005774,cellular_component vacuolar membrane;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008021,cellular_component synaptic vesicle;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031642,biological_process negative regulation of myelination;GO:0031901,cellular_component early endosome membrane;GO:0032288,biological_process myelin assembly;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0043197,cellular_component dendritic spine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045806,biological_process negative regulation of endocytosis;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048666,biological_process neuron development;GO:0051262,biological_process protein tetramerization;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0052866,molecular_function phosphatidylinositol phosphate phosphatase activity;GO:0070062,cellular_component extracellular exosome;GO:0090394,biological_process negative regulation of excitatory postsynaptic potential;GO:0097060,cellular_component synaptic membrane;GO:0097062,biological_process dendritic spine maintenance;GO:2000643,biological_process positive regulation of early endosome to late endosome transport;GO:2000645,biological_process negative regulation of receptor catabolic process	NA	myotubularin related protein 2 [Source:HGNC Symbol%3BAcc:HGNC:7450]
ENSG00000160087	42.42	39.77	41.97	42.07	40.78	40.83	0.0202529363967168	5.30768956470909	0.797262837829051	0.952813670125891	1:1253908-1273885:-	UBE2J2	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006986,biological_process response to unfolded protein;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	UBE2J2, NCUBE2, UBC6; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]; K04554	ubiquitin conjugating enzyme E2 J2 [Source:HGNC Symbol%3BAcc:HGNC:19268]
ENSG00000142920	7.69	7.47	7.72	7.95	7.24	8.41	-0.0333306361459801	3.55738023753331	0.797274577212689	0.952813670125891	1:33081103-33120530:+	AZIN2	34;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006591,biological_process ornithine metabolic process;GO:0006596,biological_process polyamine biosynthetic process;GO:0006810,biological_process transport;GO:0007283,biological_process spermatogenesis;GO:0008792,molecular_function arginine decarboxylase activity;GO:0015489,molecular_function putrescine transmembrane transporter activity;GO:0015847,biological_process putrescine transport;GO:0016020,cellular_component membrane;GO:0030133,cellular_component transport vesicle;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0033387,biological_process putrescine biosynthetic process from ornithine;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042978,molecular_function ornithine decarboxylase activator activity;GO:0042995,cellular_component cell projection;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043204,cellular_component perikaryon;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0097055,biological_process agmatine biosynthetic process;GO:0098629,biological_process trans-Golgi network membrane organization;GO:1902269,biological_process positive regulation of polyamine transmembrane transport;GO:1990005,cellular_component granular vesicle	E4.1.1.19; arginine decarboxylase [EC:4.1.1.19]; K01583	antizyme inhibitor 2 [Source:HGNC Symbol%3BAcc:HGNC:29957]
ENSG00000108854	12.79	10.03	14.70	12.92	11.54	14.30	-0.029001282926773	4.85202802359208	0.7973176778228	0.952813670125891	17:64542294-64662068:-	SMURF2	31;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0030509,biological_process BMP signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030579,biological_process ubiquitin-dependent SMAD protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0045121,cellular_component membrane raft;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046332,molecular_function SMAD binding;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901165,biological_process positive regulation of trophoblast cell migration	SMURF; E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]; K04678	SMAD specific E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:16809]
ENSG00000198242	1337.43	1339.93	1348.39	1437.60	1324.79	1339.50	-0.0153418109339534	9.91482928823018	0.797328622894404	0.952813670125891	17:28719392-28724359:+	RPL23A	23;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008283,biological_process cell proliferation;GO:0019083,biological_process viral transcription;GO:0019843,molecular_function rRNA binding;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031932,cellular_component TORC2 complex;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	RP-L23Ae, RPL23A; large subunit ribosomal protein L23Ae; K02893	ribosomal protein L23a [Source:HGNC Symbol%3BAcc:HGNC:10317]
ENSG00000198856	166.87	174.62	177.15	170.58	180.36	165.61	0.0173553080305949	6.49308637756272	0.797442096048827	0.952813670125891	4:108650583-108667820:+	OSTC	8;GO:0004579,molecular_function dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0006486,biological_process protein glycosylation;GO:0008250,cellular_component oligosaccharyltransferase complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018279,biological_process protein N-linked glycosylation via asparagine	NA	oligosaccharyltransferase complex non-catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:24448]
ENSG00000213199	3.93	3.92	4.05	4.30	3.20	4.12	0.0454543707958855	2.77645074925146	0.797452768785779	0.952813670125891	7:151048291-151052756:+	ASIC3	31;GO:0005261,molecular_function cation channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0007165,biological_process signal transduction;GO:0007600,biological_process sensory perception;GO:0009408,biological_process response to heat;GO:0009612,biological_process response to mechanical stimulus;GO:0010447,biological_process response to acidic pH;GO:0015280,molecular_function ligand-gated sodium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030165,molecular_function PDZ domain binding;GO:0034220,biological_process ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042930,biological_process enterobactin transport;GO:0042931,molecular_function enterobactin transporter activity;GO:0044736,molecular_function acid-sensing ion channel activity;GO:0050907,biological_process detection of chemical stimulus involved in sensory perception;GO:0050915,biological_process sensory perception of sour taste;GO:0050961,biological_process detection of temperature stimulus involved in sensory perception;GO:0050965,biological_process detection of temperature stimulus involved in sensory perception of pain;GO:0050966,biological_process detection of mechanical stimulus involved in sensory perception of pain;GO:0050968,biological_process detection of chemical stimulus involved in sensory perception of pain;GO:0050974,biological_process detection of mechanical stimulus involved in sensory perception;GO:0098655,biological_process cation transmembrane transport	ASIC3, ACCN3; acid-sensing ion channel 3; K04830	acid sensing ion channel subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:101]
ENSG00000085998	41.47	43.87	41.70	43.04	41.33	42.16	0.0160811206940186	6.58663950950451	0.797596424296161	0.952893591413691	1:46188681-46220305:-	POMGNT1	11;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0047223,molecular_function beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	POMGNT1; beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.-]; K09666	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1%2C2-) [Source:HGNC Symbol%3BAcc:HGNC:19139]
ENSG00000263001	69.90	70.37	68.42	65.05	73.29	69.64	0.0165360835921796	7.70265338374608	0.798087219115648	0.953388186977436	7:74657666-74760692:+	GTF2I	20;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0014886,biological_process transition between slow and fast fiber;GO:0016020,cellular_component membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051481,biological_process negative regulation of cytosolic calcium ion concentration	TFII-I, GTF2I; transcription initiation factor TFII-I; K03121	general transcription factor IIi [Source:HGNC Symbol%3BAcc:HGNC:4659]
ENSG00000139631	8.21	10.12	10.98	9.48	10.29	10.36	-0.032362846731476	4.03713846472622	0.798204845519976	0.953396606585141	12:53157662-53180909:-	CSAD	7;GO:0003824,molecular_function catalytic activity;GO:0004782,molecular_function sulfinoalanine decarboxylase activity;GO:0016829,molecular_function lyase activity;GO:0016831,molecular_function carboxy-lyase activity;GO:0019752,biological_process carboxylic acid metabolic process;GO:0030170,molecular_function pyridoxal phosphate binding;GO:0042412,biological_process taurine biosynthetic process	CSAD; sulfinoalanine decarboxylase [EC:4.1.1.29]; K01594	cysteine sulfinic acid decarboxylase [Source:HGNC Symbol%3BAcc:HGNC:18966]
ENSG00000126226	15.97	16.31	15.53	16.39	13.60	17.26	0.0252216711251521	4.47024692245815	0.798247879822716	0.953396606585141	13:113177538-113208715:-	PCID2	18;GO:0000973,biological_process posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0003690,molecular_function double-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005643,cellular_component nuclear pore;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0035327,cellular_component transcriptionally active chromatin;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043488,biological_process regulation of mRNA stability;GO:0045579,biological_process positive regulation of B cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048536,biological_process spleen development;GO:0070390,cellular_component transcription export complex 2;GO:0071033,biological_process nuclear retention of pre-mRNA at the site of transcription;GO:0090267,biological_process positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:2000117,biological_process negative regulation of cysteine-type endopeptidase activity	NA	PCI domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25653]
ENSG00000042753	267.92	286.70	264.99	284.74	258.84	272.62	0.0165771481184552	7.17143074259635	0.798334746211706	0.953408620812575	19:46838135-46850992:-	AP2S1	29;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007018,biological_process microtubule-based movement;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030100,biological_process regulation of endocytosis;GO:0030117,cellular_component membrane coat;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035615,molecular_function clathrin adaptor activity;GO:0036020,cellular_component endolysosome membrane;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048268,biological_process clathrin coat assembly;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis	AP2S1; AP-2 complex subunit sigma-1; K11827	adaptor related protein complex 2 sigma 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:565]
ENSG00000116663	1.45	1.85	1.67	1.70	2.07	1.52	-0.0892144541869685	0.720116165224691	0.798590066304852	0.953504349157566	1:11664123-11674354:+	FBXO6	19;GO:0000077,biological_process DNA damage checkpoint;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006508,biological_process proteolysis;GO:0006516,biological_process glycoprotein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006986,biological_process response to unfolded protein;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030246,molecular_function carbohydrate binding;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0061630,molecular_function ubiquitin protein ligase activity	FBXO6; F-box protein 6; K10100	F-box protein 6 [Source:HGNC Symbol%3BAcc:HGNC:13585]
ENSG00000119523	26.61	25.64	24.43	26.36	26.05	25.93	-0.0192057207584944	5.16621877762035	0.798649446824903	0.953504349157566	9:99216425-99221956:-	ALG2	20;GO:0000033,molecular_function alpha-1,3-mannosyltransferase activity;GO:0004378,molecular_function GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0033577,biological_process protein glycosylation in endoplasmic reticulum;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051592,biological_process response to calcium ion;GO:0097502,biological_process mannosylation;GO:0102704,molecular_function GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity	ALG2; alpha-1,3/alpha-1,6-mannosyltransferase [EC:2.4.1.132 2.4.1.257]; K03843	ALG2%2C alpha-1%2C3/1%2C6-mannosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:23159]
ENSG00000188167	0.42	1.34	0.92	0.83	0.89	1.14	-0.141097969392994	0.466569080332742	0.798705908106567	0.953504349157566	3:33090420-33096801:-	TMPPE	4;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	transmembrane protein with metallophosphoesterase domain [Source:HGNC Symbol%3BAcc:HGNC:33865]
ENSG00000267041	1.59	1.77	1.61	1.55	1.85	1.43	0.0509933918826218	2.46011408586986	0.798722164065123	0.953504349157566	19:36714382-36772825:-	ZNF850	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 850 [Source:HGNC Symbol%3BAcc:HGNC:27994]
ENSG00000113597	10.03	9.83	8.80	9.19	9.56	9.48	0.0315288568849403	3.58951687871205	0.799001469071978	0.953746055927538	5:65624715-65666233:+	TRAPPC13	5;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 13 [Source:HGNC Symbol%3BAcc:HGNC:25828]
ENSG00000204310	60.31	60.56	61.81	60.85	64.05	56.98	0.0189787484434451	5.69375503310317	0.799080038069003	0.953748126206782	6:32168211-32178096:-	AGPAT1	17;GO:0001819,biological_process positive regulation of cytokine production;GO:0001961,biological_process positive regulation of cytokine-mediated signaling pathway;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0031325,biological_process positive regulation of cellular metabolic process	NA	1-acylglycerol-3-phosphate O-acyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:324]
ENSG00000151500	41.96	43.89	40.78	45.03	39.55	44.90	-0.0242009929444887	4.85641114549465	0.799338455242373	0.953916186098869	11:134248278-134253370:-	THYN1	1;GO:0005634,cellular_component nucleus	NA	thymocyte nuclear protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29560]
ENSG00000119227	1.87	1.98	2.50	1.90	2.40	1.86	0.062227309377293	1.91659824262824	0.799374540223994	0.953916186098869	3:196946342-196969060:-	PIGZ	10;GO:0000026,molecular_function alpha-1,2-mannosyltransferase activity;GO:0000030,molecular_function mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0097502,biological_process mannosylation	PIGZ, SMP3; GPI mannosyltransferase 4 [EC:2.4.1.-]; K08098	phosphatidylinositol glycan anchor biosynthesis class Z [Source:HGNC Symbol%3BAcc:HGNC:30596]
ENSG00000181991	43.32	51.40	39.84	41.94	48.87	41.93	0.0248854096772763	4.70028679618932	0.799454256333643	0.953919608177402	15:88467452-88480773:+	MRPS11	16;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination;GO:0070181,molecular_function small ribosomal subunit rRNA binding	RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11; K02948	mitochondrial ribosomal protein S11 [Source:HGNC Symbol%3BAcc:HGNC:14050]
ENSG00000186767	10.02	9.59	8.57	8.82	9.54	10.83	-0.0420281403108821	2.86912361752536	0.799932195024007	0.954381454480027	X:63347227-63351344:-	SPIN4	1;GO:0007276,biological_process gamete generation	NA	spindlin family member 4 [Source:HGNC Symbol%3BAcc:HGNC:27040]
ENSG00000143368	44.81	50.04	45.07	46.68	44.66	47.76	0.0160917998629864	5.88952329878866	0.79999508852531	0.954381454480027	1:149923316-149928344:-	SF3B4	12;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome	SF3B4, SAP49; splicing factor 3B subunit 4; K12831	splicing factor 3b subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:10771]
ENSG00000183785	0.48	0.44	1.05	0.30	0.82	0.72	0.126904168111096	0.354844633924022	0.800086782648267	0.954392974313892	22:18110330-18146554:+	TUBA8	12;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	TUBA; tubulin alpha; K07374	tubulin alpha 8 [Source:HGNC Symbol%3BAcc:HGNC:12410]
ENSG00000140416	447.00	385.41	446.46	447.23	403.14	456.08	-0.0187185779999284	9.43691147488854	0.800158517979914	0.954392974313892	15:63042631-63071915:+	TPM1	45;GO:0001701,biological_process in utero embryonic development;GO:0001725,cellular_component stress fiber;GO:0003065,biological_process positive regulation of heart rate by epinephrine;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005862,cellular_component muscle thin filament tropomyosin;GO:0005884,cellular_component actin filament;GO:0006928,biological_process movement of cell or subcellular component;GO:0006936,biological_process muscle contraction;GO:0006937,biological_process regulation of muscle contraction;GO:0007010,biological_process cytoskeleton organization;GO:0007015,biological_process actin filament organization;GO:0008016,biological_process regulation of heart contraction;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008307,molecular_function structural constituent of muscle;GO:0008360,biological_process regulation of cell shape;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030016,cellular_component myofibril;GO:0030017,cellular_component sarcomere;GO:0030049,biological_process muscle filament sliding;GO:0030336,biological_process negative regulation of cell migration;GO:0031529,biological_process ruffle organization;GO:0031941,cellular_component filamentous actin;GO:0032059,cellular_component bleb;GO:0032587,cellular_component ruffle membrane;GO:0032781,biological_process positive regulation of ATPase activity;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0042060,biological_process wound healing;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045214,biological_process sarcomere organization;GO:0045785,biological_process positive regulation of cell adhesion;GO:0046982,molecular_function protein heterodimerization activity;GO:0051015,molecular_function actin filament binding;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0060048,biological_process cardiac muscle contraction;GO:1904706,biological_process negative regulation of vascular smooth muscle cell proliferation;GO:1904753,biological_process negative regulation of vascular associated smooth muscle cell migration	TPM1; tropomyosin 1; K10373	tropomyosin 1 [Source:HGNC Symbol%3BAcc:HGNC:12010]
ENSG00000179115	29.91	29.29	30.03	30.55	29.15	29.24	0.017508342016045	5.75410927967603	0.800471989391103	0.954514137437158	19:12922478-12934037:-	FARSA	17;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004826,molecular_function phenylalanine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006432,biological_process phenylalanyl-tRNA aminoacylation;GO:0009328,cellular_component phenylalanine-tRNA ligase complex;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0043039,biological_process tRNA aminoacylation;GO:0051290,biological_process protein heterotetramerization	FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]; K01889	phenylalanyl-tRNA synthetase alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:3592]
ENSG00000186687	10.64	18.99	17.46	16.80	14.83	17.58	-0.0699525940141906	2.35738660369071	0.800537345598886	0.954514137437158	5:131170809-131205426:+	LYRM7	6;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0031966,cellular_component mitochondrial membrane;GO:0034551,biological_process mitochondrial respiratory chain complex III assembly;GO:0045333,biological_process cellular respiration	NA	LYR motif containing 7 [Source:HGNC Symbol%3BAcc:HGNC:28072]
ENSG00000203705	9.83	10.95	9.69	11.22	10.15	10.01	-0.0379883133201434	3.28726167198949	0.800576860641836	0.954514137437158	1:212791827-212816626:+	TATDN3	6;GO:0004518,molecular_function nuclease activity;GO:0005634,cellular_component nucleus;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	TatD DNase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:27010]
ENSG00000161558	4.46	5.97	5.71	6.06	5.47	5.16	-0.0468299875131819	3.01668120645323	0.8006354468698	0.954514137437158	19:48332355-48364237:-	TMEM143	5;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 143 [Source:HGNC Symbol%3BAcc:HGNC:25603]
ENSG00000130684	17.96	17.77	19.05	17.11	17.50	19.85	0.0201281490535131	5.36547395323628	0.80064458221185	0.954514137437158	20:25674214-25696841:-	ZNF337	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 337 [Source:HGNC Symbol%3BAcc:HGNC:15809]
ENSG00000230124	48.75	44.85	44.54	48.68	45.54	43.22	0.0216965900581299	5.28706444148312	0.800920292028981	0.954737358974086	1:180269652-180502954:-	ACBD6	5;GO:0000062,molecular_function fatty-acyl-CoA binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008289,molecular_function lipid binding	NA	acyl-CoA binding domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:23339]
ENSG00000225190	6.82	7.34	7.70	7.97	6.73	7.71	-0.0261512952433981	4.57227381017182	0.800985648622906	0.954737358974086	17:45435899-45490749:-	PLEKHM1	14;GO:0005622,cellular_component intracellular;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0035556,biological_process intracellular signal transduction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	NA	pleckstrin homology and RUN domain containing M1 [Source:HGNC Symbol%3BAcc:HGNC:29017]
ENSG00000213123	4.86	4.88	5.35	5.00	3.58	5.80	0.0768971273113918	1.41107897867237	0.8013582674262	0.955048483754283	3:196291218-196318299:-	TCTEX1D2	11;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005813,cellular_component centrosome;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005930,cellular_component axoneme;GO:0031021,cellular_component interphase microtubule organizing center;GO:0045505,molecular_function dynein intermediate chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0097546,cellular_component ciliary base;GO:1902017,biological_process regulation of cilium assembly;GO:1905799,biological_process regulation of intraciliary retrograde transport	NA	Tctex1 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28482]
ENSG00000135002	26.94	24.66	25.56	26.57	24.18	28.69	-0.0281521138639526	3.80147115657732	0.80140054835935	0.955048483754283	9:76385516-76394517:-	RFK	16;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006771,biological_process riboflavin metabolic process;GO:0006915,biological_process apoptotic process;GO:0008531,molecular_function riboflavin kinase activity;GO:0009231,biological_process riboflavin biosynthetic process;GO:0009398,biological_process FMN biosynthetic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0033864,biological_process positive regulation of NAD(P)H oxidase activity;GO:0046872,molecular_function metal ion binding;GO:0072593,biological_process reactive oxygen species metabolic process	RFK, FMN1; riboflavin kinase [EC:2.7.1.26]; K00861	riboflavin kinase [Source:HGNC Symbol%3BAcc:HGNC:30324]
ENSG00000102452	0.54	0.48	0.82	0.66	0.49	0.62	0.074764040653518	1.72956452859372	0.801639427008601	0.955170821118939	13:101053775-101416492:-	NALCN	22;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005272,molecular_function sodium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006816,biological_process calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022840,molecular_function leak channel activity;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0060075,biological_process regulation of resting membrane potential;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:0086010,biological_process membrane depolarization during action potential;GO:0098655,biological_process cation transmembrane transport	NA	sodium leak channel%2C non-selective [Source:HGNC Symbol%3BAcc:HGNC:19082]
ENSG00000100038	6.87	7.02	7.16	6.99	6.91	7.68	-0.0255263722819652	4.31415519346552	0.801668957226594	0.955170821118939	22:21957024-21982816:-	TOP3B	10;GO:0000793,cellular_component condensed chromosome;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003916,molecular_function DNA topoisomerase activity;GO:0003917,molecular_function DNA topoisomerase type I activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006265,biological_process DNA topological change;GO:0007059,biological_process chromosome segregation;GO:0016853,molecular_function isomerase activity	TOP3; DNA topoisomerase III [EC:5.6.2.1]; K03165	topoisomerase (DNA) III beta [Source:HGNC Symbol%3BAcc:HGNC:11993]
ENSG00000105341	48.45	47.61	46.93	48.10	49.83	48.07	-0.0178624136465256	5.3188265472853	0.801760536303706	0.955170821118939	19:41431317-41440717:-	DMAC2	3;GO:0005739,cellular_component mitochondrion;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NA	distal membrane arm assembly complex 2 [Source:HGNC Symbol%3BAcc:HGNC:25496]
ENSG00000185236	100.12	91.35	89.94	91.17	102.83	93.59	-0.0178492362399897	6.0157490316257	0.80181100105207	0.955170821118939	19:8389980-8404434:+	RAB11B	40;GO:0000166,molecular_function nucleotide binding;GO:0001881,biological_process receptor recycling;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0008021,cellular_component synaptic vesicle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0030054,cellular_component cell junction;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031489,molecular_function myosin V binding;GO:0032402,biological_process melanosome transport;GO:0033572,biological_process transferrin transport;GO:0035773,biological_process insulin secretion involved in cellular response to glucose stimulus;GO:0043687,biological_process post-translational protein modification;GO:0044070,biological_process regulation of anion transport;GO:0045054,biological_process constitutive secretory pathway;GO:0045055,biological_process regulated exocytosis;GO:0045056,biological_process transcytosis;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0045335,cellular_component phagocytic vesicle;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0071468,biological_process cellular response to acidic pH;GO:0090150,biological_process establishment of protein localization to membrane;GO:0098993,cellular_component anchored component of synaptic vesicle membrane;GO:1990126,biological_process retrograde transport, endosome to plasma membrane;GO:2000008,biological_process regulation of protein localization to cell surface;GO:2001135,biological_process regulation of endocytic recycling	RAB11B; Ras-related protein Rab-11B; K07905	RAB11B%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9761]
ENSG00000088179	9.27	7.94	7.42	9.22	8.79	7.36	-0.026712019487658	4.61790532657854	0.801979731160367	0.955242937793623	2:119759630-119983818:+	PTPN4	15;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation	NA	protein tyrosine phosphatase%2C non-receptor type 4 [Source:HGNC Symbol%3BAcc:HGNC:9656]
ENSG00000116221	61.59	62.47	66.31	67.08	63.18	63.91	-0.0164065609202024	6.82636082291025	0.802052413419796	0.955242937793623	1:54184040-54225464:+	MRPL37	11;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L37 [Source:HGNC Symbol%3BAcc:HGNC:14034]
ENSG00000130150	19.45	20.07	19.92	19.76	19.51	19.84	0.0183225042933658	5.03561693384481	0.802164892122328	0.955242937793623	X:14873440-14922327:+	MOSPD2	5;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation	NA	motile sperm domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28381]
ENSG00000013573	15.94	15.46	15.75	16.81	15.38	15.94	-0.0169890005770279	5.72302771492004	0.802202119922305	0.955242937793623	12:31073844-31104791:+	DDX11	60;GO:0000166,molecular_function nucleotide binding;GO:0000790,cellular_component nuclear chromatin;GO:0000922,cellular_component spindle pole;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003688,molecular_function DNA replication origin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007062,biological_process sister chromatid cohesion;GO:0007275,biological_process multicellular organism development;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008186,molecular_function RNA-dependent ATPase activity;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0030496,cellular_component midbody;GO:0031297,biological_process replication fork processing;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0032079,biological_process positive regulation of endodeoxyribonuclease activity;GO:0032091,biological_process negative regulation of protein binding;GO:0032508,biological_process DNA duplex unwinding;GO:0035563,biological_process positive regulation of chromatin binding;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0044806,biological_process G-quadruplex DNA unwinding;GO:0045142,molecular_function triplex DNA binding;GO:0045876,biological_process positive regulation of sister chromatid cohesion;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0051880,molecular_function G-quadruplex DNA binding;GO:0070062,cellular_component extracellular exosome;GO:0072711,biological_process cellular response to hydroxyurea;GO:0072719,biological_process cellular response to cisplatin;GO:1901838,biological_process positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1904976,biological_process cellular response to bleomycin;GO:1990700,biological_process nucleolar chromatin organization;GO:2000781,biological_process positive regulation of double-strand break repair	NA	DEAD/H-box helicase 11 [Source:HGNC Symbol%3BAcc:HGNC:2736]
ENSG00000171295	7.28	7.35	6.32	6.43	7.44	7.72	-0.036256564041836	3.68609794011032	0.802310880942801	0.955242937793623	19:11814283-11835201:+	ZNF440	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 440 [Source:HGNC Symbol%3BAcc:HGNC:20874]
ENSG00000175115	23.68	24.34	26.55	26.99	23.45	25.74	-0.0188013805737361	6.34383321340715	0.802361897698769	0.955242937793623	11:66070362-66244747:+	PACS1	9;GO:0000042,biological_process protein targeting to Golgi;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0016032,biological_process viral process;GO:0030137,cellular_component COPI-coated vesicle;GO:0044325,molecular_function ion channel binding;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0072661,biological_process protein targeting to plasma membrane	NA	phosphofurin acidic cluster sorting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30032]
ENSG00000180332	1.73	2.09	2.27	1.45	2.25	2.08	0.0820494987821201	0.752726234974321	0.802554796532933	0.955242937793623	13:45192852-45194717:-	KCTD4	2;GO:0005515,molecular_function protein binding;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:23227]
ENSG00000145022	17.37	17.94	19.53	20.35	17.18	16.16	0.0449743611297304	2.52101971857803	0.802555357658984	0.955242937793623	3:49412205-49416475:+	TCTA	6;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0072675,biological_process osteoclast fusion	NA	T-cell leukemia translocation altered [Source:HGNC Symbol%3BAcc:HGNC:11692]
ENSG00000061936	14.18	14.48	14.21	14.61	15.07	12.95	0.0202487189892399	5.42718961766828	0.802564134234246	0.955242937793623	12:131711080-131799737:+	SFSWAP	11;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000395,biological_process mRNA 5'-splice site recognition;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome	NA	splicing factor SWAP homolog [Source:HGNC Symbol%3BAcc:HGNC:10790]
ENSG00000205765	39.55	35.11	34.86	37.04	32.65	39.08	0.0230993918506318	5.12006158800941	0.803048502616051	0.955727810448038	5:41904187-41921636:+	C5orf51	2;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol	NA	chromosome 5 open reading frame 51 [Source:HGNC Symbol%3BAcc:HGNC:27750]
ENSG00000090989	32.60	27.65	31.39	29.06	33.11	31.57	-0.0179069548313197	6.37779322293572	0.803238644222482	0.955775551463606	4:55853615-55905034:+	EXOC1	18;GO:0000145,cellular_component exocyst;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0017049,molecular_function GTP-Rho binding;GO:0030496,cellular_component midbody;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050714,biological_process positive regulation of protein secretion;GO:0051601,biological_process exocyst localization;GO:0098592,cellular_component cytoplasmic side of apical plasma membrane	NA	exocyst complex component 1 [Source:HGNC Symbol%3BAcc:HGNC:30380]
ENSG00000157869	26.99	28.81	25.93	27.78	25.41	27.74	0.0206190587711157	4.45856305126461	0.803242612814657	0.955775551463606	4:13361353-13484365:-	RAB28	12;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0035253,cellular_component ciliary rootlet;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:1901998,biological_process toxin transport	NA	RAB28%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9768]
ENSG00000166598	645.61	683.87	624.66	622.62	677.27	649.07	0.0155854628460365	10.6269070955765	0.80358565625072	0.956092087706335	12:103930106-103953645:+	HSP90B1	44;GO:0000166,molecular_function nucleotide binding;GO:0001666,biological_process response to hypoxia;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0003723,molecular_function RNA binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006457,biological_process protein folding;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006950,biological_process response to stress;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0019903,molecular_function protein phosphatase binding;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030496,cellular_component midbody;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0031012,cellular_component extracellular matrix;GO:0031247,biological_process actin rod assembly;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036500,biological_process ATF6-mediated unfolded protein response;GO:0042470,cellular_component melanosome;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043666,biological_process regulation of phosphoprotein phosphatase activity;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046790,molecular_function virion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0051082,molecular_function unfolded protein binding;GO:0051208,biological_process sequestering of calcium ion;GO:0070062,cellular_component extracellular exosome;GO:0071318,biological_process cellular response to ATP;GO:0071682,cellular_component endocytic vesicle lumen	HSP90B, TRA1; heat shock protein 90kDa beta; K09487	heat shock protein 90 beta family member 1 [Source:HGNC Symbol%3BAcc:HGNC:12028]
ENSG00000120509	125.11	119.68	111.80	123.18	126.04	115.02	-0.0183205074625721	5.66210616955559	0.80377525111573	0.956180555181927	X:70286594-70290514:-	PDZD11	16;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005911,cellular_component cell-cell junction;GO:0006768,biological_process biotin metabolic process;GO:0007269,biological_process neurotransmitter secretion;GO:0015939,biological_process pantothenate metabolic process;GO:0016323,cellular_component basolateral plasma membrane;GO:0019730,biological_process antimicrobial humoral response;GO:0034220,biological_process ion transmembrane transport;GO:0045199,biological_process maintenance of epithelial cell apical/basal polarity;GO:0045202,cellular_component synapse;GO:0055085,biological_process transmembrane transport;GO:0098793,cellular_component presynapse;GO:1903361,biological_process protein localization to basolateral plasma membrane	NA	PDZ domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:28034]
ENSG00000143919	6.18	5.40	5.89	5.50	6.07	5.63	0.0436888389591892	2.65661853369009	0.803814073416854	0.956180555181927	2:44361949-44772592:+	CAMKMT	14;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006479,biological_process protein methylation;GO:0007005,biological_process mitochondrion organization;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0018025,molecular_function calmodulin-lysine N-methyltransferase activity;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0031072,molecular_function heat shock protein binding;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex	NA	calmodulin-lysine N-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:26276]
ENSG00000112787	5.54	5.67	6.07	5.45	5.71	6.01	0.0217592383340737	4.67274784102942	0.803947362571363	0.956247471406509	12:132489550-132585188:+	FBRSL1	1;GO:0003723,molecular_function RNA binding	NA	fibrosin like 1 [Source:HGNC Symbol%3BAcc:HGNC:29308]
ENSG00000115649	42.07	38.20	44.30	44.72	43.33	39.42	-0.0175658005472223	5.78948411078438	0.804192663223153	0.956447593042924	2:219171896-219178106:-	CNPPD1	4;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019901,molecular_function protein kinase binding	NA	cyclin Pas1/PHO80 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25220]
ENSG00000118680	931.96	1019.74	927.00	965.94	1006.53	961.42	-0.0160066573906192	8.96667943564881	0.804365292089621	0.956535924383949	18:3261908-3278284:+	MYL12B	15;GO:0001725,cellular_component stress fiber;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005903,cellular_component brush border;GO:0006936,biological_process muscle contraction;GO:0008360,biological_process regulation of cell shape;GO:0016459,cellular_component myosin complex;GO:0016460,cellular_component myosin II complex;GO:0030018,cellular_component Z disc;GO:0032036,molecular_function myosin heavy chain binding;GO:0045177,cellular_component apical part of cell;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0099738,cellular_component cell cortex region	NA	myosin light chain 12B [Source:HGNC Symbol%3BAcc:HGNC:29827]
ENSG00000197969	9.11	10.76	9.72	9.55	10.04	9.84	0.0169988788579428	6.58334580386178	0.804421051691295	0.956535924383949	9:77177352-77421541:+	VPS13A	12;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0006914,biological_process autophagy;GO:0007399,biological_process nervous system development;GO:0007626,biological_process locomotory behavior;GO:0008104,biological_process protein localization;GO:0015031,biological_process protein transport;GO:0031045,cellular_component dense core granule;GO:0035176,biological_process social behavior	NA	vacuolar protein sorting 13 homolog A [Source:HGNC Symbol%3BAcc:HGNC:1908]
ENSG00000035681	29.16	25.49	27.78	29.93	25.89	28.44	-0.0176932760172611	6.36747588881741	0.804707502639225	0.956660753669322	8:58583503-58659844:-	NSMAF	10;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006672,biological_process ceramide metabolic process;GO:0007165,biological_process signal transduction;GO:0016230,molecular_function sphingomyelin phosphodiesterase activator activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:2000304,biological_process positive regulation of ceramide biosynthetic process	NA	neutral sphingomyelinase activation associated factor [Source:HGNC Symbol%3BAcc:HGNC:8017]
ENSG00000173950	4.03	4.63	4.77	3.93	4.92	5.07	-0.0446411756224882	2.82927751569531	0.804756145916681	0.956660753669322	3:195068278-195271167:-	XXYLT1	12;GO:0000287,molecular_function magnesium ion binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030145,molecular_function manganese ion binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0035252,molecular_function UDP-xylosyltransferase activity;GO:0046872,molecular_function metal ion binding	NA	xyloside xylosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:26639]
ENSG00000141179	13.07	13.37	13.23	13.38	14.43	13.01	-0.0299828329653954	3.69066507940419	0.80480840678942	0.956660753669322	17:55750978-55842830:+	PCTP	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0008525,molecular_function phosphatidylcholine transporter activity;GO:0015914,biological_process phospholipid transport;GO:0031210,molecular_function phosphatidylcholine binding	NA	phosphatidylcholine transfer protein [Source:HGNC Symbol%3BAcc:HGNC:8752]
ENSG00000159267	10.46	9.30	11.47	12.15	9.18	10.82	-0.0258789724752229	4.80241752550297	0.804849410940023	0.956660753669322	21:36750887-36990236:-	HLCS	27;GO:0000166,molecular_function nucleotide binding;GO:0000785,cellular_component chromatin;GO:0003824,molecular_function catalytic activity;GO:0004077,molecular_function biotin-[acetyl-CoA-carboxylase] ligase activity;GO:0004078,molecular_function biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity;GO:0004079,molecular_function biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity;GO:0004080,molecular_function biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005652,cellular_component nuclear lamina;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006768,biological_process biotin metabolic process;GO:0008152,biological_process metabolic process;GO:0008283,biological_process cell proliferation;GO:0009305,biological_process protein biotinylation;GO:0009374,molecular_function biotin binding;GO:0016363,cellular_component nuclear matrix;GO:0016570,biological_process histone modification;GO:0016874,molecular_function ligase activity;GO:0018271,molecular_function biotin-protein ligase activity;GO:0019899,molecular_function enzyme binding;GO:0042803,molecular_function protein homodimerization activity;GO:0070781,biological_process response to biotin;GO:0071110,biological_process histone biotinylation	HLCS; biotin---protein ligase [EC:6.3.4.9 6.3.4.10 6.3.4.11 6.3.4.15]; K01942	holocarboxylase synthetase [Source:HGNC Symbol%3BAcc:HGNC:4976]
ENSG00000124313	4.31	4.30	5.13	4.57	4.84	4.22	0.0271228564511132	4.52204257559837	0.805083822097701	0.956660753669322	X:53225827-53321328:-	IQSEC2	5;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0030036,biological_process actin cytoskeleton organization;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	IQ motif and Sec7 domain 2 [Source:HGNC Symbol%3BAcc:HGNC:29059]
ENSG00000108861	35.97	37.76	38.85	35.99	38.30	37.52	0.0204883562371527	4.72100386581308	0.805172629401305	0.956660753669322	17:43766120-43778988:-	DUSP3	23;GO:0000188,biological_process inactivation of MAPK activity;GO:0001701,biological_process in utero embryonic development;GO:0001772,cellular_component immunological synapse;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019901,molecular_function protein kinase binding;GO:0033549,molecular_function MAP kinase phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0046329,biological_process negative regulation of JNK cascade;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0050868,biological_process negative regulation of T cell activation;GO:0070062,cellular_component extracellular exosome;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 3 [Source:HGNC Symbol%3BAcc:HGNC:3069]
ENSG00000167526	1516.14	1424.44	1392.42	1476.41	1401.82	1537.38	-0.0153851115338928	9.96935913069595	0.805354379635955	0.956660753669322	16:89560656-89566828:+	RPL13	17;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0022626,cellular_component cytosolic ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L13e, RPL13; large subunit ribosomal protein L13e; K02873	ribosomal protein L13 [Source:HGNC Symbol%3BAcc:HGNC:10303]
ENSG00000177943	6.69	6.31	8.48	6.97	7.34	7.79	-0.025376778724823	4.7639095634934	0.805503069374235	0.956660753669322	9:136850942-136860799:+	MAMDC4	4;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	MAM domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:24083]
ENSG00000134146	5.14	7.42	6.57	6.91	6.41	6.49	-0.0527299002861386	2.7654692342669	0.805557272840605	0.956660753669322	15:35217344-35546193:-	DPH6	10;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0016874,molecular_function ligase activity;GO:0017178,molecular_function diphthine-ammonia ligase activity;GO:0017183,biological_process peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0031647,biological_process regulation of protein stability;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	diphthamine biosynthesis 6 [Source:HGNC Symbol%3BAcc:HGNC:30543]
ENSG00000137106	63.89	67.42	67.01	63.91	68.12	65.67	0.0156133597157545	6.81927623615991	0.805595307842466	0.956660753669322	9:37422665-37436990:+	GRHPR	20;GO:0005737,cellular_component cytoplasm;GO:0005782,cellular_component peroxisomal matrix;GO:0005829,cellular_component cytosol;GO:0007588,biological_process excretion;GO:0008152,biological_process metabolic process;GO:0008465,molecular_function glycerate dehydrogenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016618,molecular_function hydroxypyruvate reductase activity;GO:0030267,molecular_function glyoxylate reductase (NADP) activity;GO:0031406,molecular_function carboxylic acid binding;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043648,biological_process dicarboxylic acid metabolic process;GO:0050661,molecular_function NADP binding;GO:0051259,biological_process protein oligomerization;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070402,molecular_function NADPH binding	GRHPR; glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]; K00049	glyoxylate and hydroxypyruvate reductase [Source:HGNC Symbol%3BAcc:HGNC:4570]
ENSG00000115091	238.52	237.54	235.24	243.72	242.83	237.65	-0.0141895364456418	8.23058677561521	0.805670328735765	0.956660753669322	2:113889959-113962596:+	ACTR3	32;GO:0000166,molecular_function nucleotide binding;GO:0003779,molecular_function actin binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0005903,cellular_component brush border;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0007015,biological_process actin filament organization;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0008356,biological_process asymmetric cell division;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016344,biological_process meiotic chromosome movement towards spindle pole;GO:0030027,cellular_component lamellipodium;GO:0030030,biological_process cell projection organization;GO:0033206,biological_process meiotic cytokinesis;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0051015,molecular_function actin filament binding;GO:0051321,biological_process meiotic cell cycle;GO:0051653,biological_process spindle localization;GO:0060271,biological_process cilium morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	NA	ARP3 actin related protein 3 homolog [Source:HGNC Symbol%3BAcc:HGNC:170]
ENSG00000186814	9.56	9.13	10.54	8.92	10.19	9.85	0.0296277069538873	4.2226168676878	0.805708810981666	0.956660753669322	18:35251057-35290245:-	ZSCAN30	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 30 [Source:HGNC Symbol%3BAcc:HGNC:33517]
ENSG00000204267	1.69	1.88	1.76	1.47	1.49	2.18	0.0511283255025391	1.95451164676999	0.805721030774653	0.956660753669322	6:32821832-32838780:-	TAP2	36;GO:0000166,molecular_function nucleotide binding;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002489,biological_process antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0015197,molecular_function peptide transporter activity;GO:0015433,molecular_function peptide antigen-transporting ATPase activity;GO:0015440,molecular_function peptide-transporting ATPase activity;GO:0015833,biological_process peptide transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016607,cellular_component nuclear speck;GO:0016887,molecular_function ATPase activity;GO:0019885,biological_process antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0023029,molecular_function MHC class Ib protein binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042287,molecular_function MHC protein binding;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042825,cellular_component TAP complex;GO:0046967,biological_process cytosol to ER transport;GO:0046968,biological_process peptide antigen transport;GO:0046978,molecular_function TAP1 binding;GO:0046980,molecular_function tapasin binding;GO:0055085,biological_process transmembrane transport;GO:1990668,biological_process vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3; K05654	transporter 2%2C ATP binding cassette subfamily B member [Source:HGNC Symbol%3BAcc:HGNC:44]
ENSG00000154099	1.64	1.51	2.00	1.80	1.99	1.60	-0.0440565198390335	2.06308169175629	0.805734058752898	0.956660753669322	16:84145286-84178767:+	DNAAF1	24;GO:0000922,cellular_component spindle pole;GO:0001947,biological_process heart looping;GO:0003341,biological_process cilium movement;GO:0003356,biological_process regulation of cilium beat frequency;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0016607,cellular_component nuclear speck;GO:0030324,biological_process lung development;GO:0035469,biological_process determination of pancreatic left/right asymmetry;GO:0036158,biological_process outer dynein arm assembly;GO:0036159,biological_process inner dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0044458,biological_process motile cilium assembly;GO:0060271,biological_process cilium morphogenesis;GO:0060287,biological_process epithelial cilium movement involved in determination of left/right asymmetry;GO:0060972,biological_process left/right pattern formation;GO:0070286,biological_process axonemal dynein complex assembly;GO:0070840,molecular_function dynein complex binding;GO:0071907,biological_process determination of digestive tract left/right asymmetry;GO:0071910,biological_process determination of liver left/right asymmetry	NA	dynein axonemal assembly factor 1 [Source:HGNC Symbol%3BAcc:HGNC:30539]
ENSG00000005020	119.59	120.52	120.15	114.66	126.91	125.73	-0.0162628346383677	7.06068941287295	0.805753006321013	0.956660753669322	7:26667061-26995239:-	SKAP2	11;GO:0002757,biological_process immune response-activating signal transduction;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006461,biological_process protein complex assembly;GO:0007165,biological_process signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009967,biological_process positive regulation of signal transduction;GO:0042113,biological_process B cell activation	NA	src kinase associated phosphoprotein 2 [Source:HGNC Symbol%3BAcc:HGNC:15687]
ENSG00000215472	2.71	1.84	2.12	2.36	2.18	1.74	0.122159189325803	0.794878325302739	0.805808507378593	0.956660753669322	18:49481680-49492479:-	RPL17-C18orf32	6;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015934,cellular_component large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	RPL17-C18orf32 readthrough [Source:HGNC Symbol%3BAcc:HGNC:44661]
ENSG00000105821	27.44	26.70	28.21	28.31	27.70	28.01	-0.0157582582939938	5.74978010046993	0.80591436679648	0.956660753669322	7:103312473-103344873:-	DNAJC2	21;GO:0001671,molecular_function ATPase activator activity;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0030544,molecular_function Hsp70 protein binding;GO:0031965,cellular_component nuclear membrane;GO:0032781,biological_process positive regulation of ATPase activity;GO:0042393,molecular_function histone binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051083,biological_process 'de novo' cotranslational protein folding;GO:0061649,molecular_function ubiquitinated histone binding;GO:1900034,biological_process regulation of cellular response to heat;GO:2000279,biological_process negative regulation of DNA biosynthetic process	NA	DnaJ heat shock protein family (Hsp40) member C2 [Source:HGNC Symbol%3BAcc:HGNC:13192]
ENSG00000087157	13.52	9.70	11.57	12.76	11.75	11.40	-0.024677314457228	4.43423778025614	0.805947885317173	0.956660753669322	17:78378639-78425114:+	PGS1	15;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005509,molecular_function calcium ion binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0006629,biological_process lipid metabolic process;GO:0006655,biological_process phosphatidylglycerol biosynthetic process;GO:0008444,molecular_function CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0017169,molecular_function CDP-alcohol phosphatidyltransferase activity;GO:0032049,biological_process cardiolipin biosynthetic process;GO:0046339,biological_process diacylglycerol metabolic process	pgsA, PGS1; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]; K00995	phosphatidylglycerophosphate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:30029]
ENSG00000084774	15.90	16.51	15.83	16.15	15.70	16.25	0.0150092049699606	6.78238826353141	0.805990345756366	0.956660753669322	2:27217389-27243943:+	CAD	43;GO:0000050,biological_process urea cycle;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004070,molecular_function aspartate carbamoyltransferase activity;GO:0004087,molecular_function carbamoyl-phosphate synthase (ammonia) activity;GO:0004088,molecular_function carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004151,molecular_function dihydroorotase activity;GO:0004672,molecular_function protein kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006207,biological_process 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006526,biological_process arginine biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0006807,biological_process nitrogen compound metabolic process;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0016597,molecular_function amino acid binding;GO:0016740,molecular_function transferase activity;GO:0016743,molecular_function carboxyl- or carbamoyltransferase activity;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016812,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016874,molecular_function ligase activity;GO:0017144,biological_process drug metabolic process;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043195,cellular_component terminal bouton;GO:0044205,biological_process 'de novo' UMP biosynthetic process;GO:0046134,biological_process pyrimidine nucleoside biosynthetic process;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070335,molecular_function aspartate binding	CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]; K11540	carbamoyl-phosphate synthetase 2%2C aspartate transcarbamylase%2C and dihydroorotase [Source:HGNC Symbol%3BAcc:HGNC:1424]
ENSG00000124074	17.35	16.39	18.36	18.90	14.76	20.05	-0.0307717883687878	4.21043758674132	0.806239230598117	0.95686466865039	16:67662944-67667265:-	ENKD1	3;GO:0005515,molecular_function protein binding;GO:0005881,cellular_component cytoplasmic microtubule;GO:0015630,cellular_component microtubule cytoskeleton	NA	enkurin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25246]
ENSG00000132394	14.18	13.90	15.85	15.79	13.53	15.73	-0.0228392897584816	4.73978047462749	0.806520644847864	0.957071882546748	3:128153453-128408646:+	EEFSEC	13;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0001514,biological_process selenocysteine incorporation;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035368,molecular_function selenocysteine insertion sequence binding;GO:0043021,molecular_function ribonucleoprotein complex binding	NA	eukaryotic elongation factor%2C selenocysteine-tRNA specific [Source:HGNC Symbol%3BAcc:HGNC:24614]
ENSG00000076554	16.61	15.34	14.60	14.49	13.89	17.60	0.0281043708953001	4.04558276173038	0.806678834377199	0.957071882546748	8:80034744-80231232:-	TPD52	10;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030183,biological_process B cell differentiation;GO:0042803,molecular_function protein homodimerization activity;GO:0046903,biological_process secretion;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	tumor protein D52 [Source:HGNC Symbol%3BAcc:HGNC:12005]
ENSG00000160799	60.63	56.41	54.28	56.05	57.76	61.41	-0.0201785935253795	4.96384209572379	0.806745418925192	0.957071882546748	3:46921725-46982010:-	CCDC12	6;GO:0000166,molecular_function nucleotide binding;GO:0004814,molecular_function arginine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006420,biological_process arginyl-tRNA aminoacylation	CCDC12; coiled-coil domain-containing protein 12; K12871	coiled-coil domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:28332]
ENSG00000081154	136.94	131.04	144.71	138.83	133.82	138.97	0.0171745785867281	6.34516337720298	0.80682744438876	0.957071882546748	3:101574094-101594437:+	PCNP	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	NA	PEST proteolytic signal containing nuclear protein [Source:HGNC Symbol%3BAcc:HGNC:30023]
ENSG00000136040	0.31	0.34	0.30	0.30	0.42	0.18	0.102457089009061	0.675311956744598	0.80690162191787	0.957071882546748	12:94148722-94307675:+	PLXNC1	13;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007165,biological_process signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017154,molecular_function semaphorin receptor activity;GO:0043087,biological_process regulation of GTPase activity;GO:0050772,biological_process positive regulation of axonogenesis;GO:0071526,biological_process semaphorin-plexin signaling pathway	PLXNC, CD232; plexin C; K06572	plexin C1 [Source:HGNC Symbol%3BAcc:HGNC:9106]
ENSG00000170558	76.82	72.32	77.78	81.01	70.67	79.86	-0.0168288391644535	7.7516450206472	0.807044381611211	0.957071882546748	18:27950965-28177446:-	CDH2	60;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005916,cellular_component fascia adherens;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008013,molecular_function beta-catenin binding;GO:0009966,biological_process regulation of signal transduction;GO:0009986,cellular_component cell surface;GO:0010001,biological_process glial cell differentiation;GO:0014069,cellular_component postsynaptic density;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016342,cellular_component catenin complex;GO:0016477,biological_process cell migration;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0021537,biological_process telencephalon development;GO:0021987,biological_process cerebral cortex development;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0034332,biological_process adherens junction organization;GO:0042383,cellular_component sarcolemma;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0044331,biological_process cell-cell adhesion mediated by cadherin;GO:0044853,cellular_component plasma membrane raft;GO:0045202,cellular_component synapse;GO:0045294,molecular_function alpha-catenin binding;GO:0045295,molecular_function gamma-catenin binding;GO:0046872,molecular_function metal ion binding;GO:0048514,biological_process blood vessel morphogenesis;GO:0048854,biological_process brain morphogenesis;GO:0048872,biological_process homeostasis of number of cells;GO:0051146,biological_process striated muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0060019,biological_process radial glial cell differentiation;GO:0060563,biological_process neuroepithelial cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0070445,biological_process regulation of oligodendrocyte progenitor proliferation;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0097118,biological_process neuroligin clustering involved in postsynaptic membrane assembly;GO:0097150,biological_process neuronal stem cell population maintenance;GO:1902897,biological_process regulation of postsynaptic density protein 95 clustering;GO:2000809,biological_process positive regulation of synaptic vesicle clustering	CDH2, CDHN, CD325; cadherin 2, type 1, N-cadherin; K06736	cadherin 2 [Source:HGNC Symbol%3BAcc:HGNC:1759]
ENSG00000137404	18.95	24.91	21.51	22.54	22.74	21.62	-0.031510408981888	4.34348818319499	0.807061434489271	0.957071882546748	6:30688046-30691420:-	NRM	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane	NA	nurim (nuclear envelope membrane protein) [Source:HGNC Symbol%3BAcc:HGNC:8003]
ENSG00000213722	24.78	26.80	27.14	24.93	27.46	25.69	0.0215449631795834	4.55657339846865	0.807064519539517	0.957071882546748	6:31727037-31730617:-	DDAH2	18;GO:0000052,biological_process citrulline metabolic process;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006525,biological_process arginine metabolic process;GO:0006527,biological_process arginine catabolic process;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0007263,biological_process nitric oxide mediated signal transduction;GO:0016403,molecular_function dimethylargininase activity;GO:0016597,molecular_function amino acid binding;GO:0016787,molecular_function hydrolase activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0070062,cellular_component extracellular exosome	NA	dimethylarginine dimethylaminohydrolase 2 [Source:HGNC Symbol%3BAcc:HGNC:2716]
ENSG00000115677	300.29	318.41	298.61	310.91	319.18	304.07	-0.0145980030840172	10.2917411007419	0.807169377900445	0.957071882546748	2:241227263-241317061:-	HDLBP	16;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008289,molecular_function lipid binding;GO:0034364,cellular_component high-density lipoprotein particle;GO:0034384,biological_process high-density lipoprotein particle clearance;GO:0045296,molecular_function cadherin binding	NA	high density lipoprotein binding protein [Source:HGNC Symbol%3BAcc:HGNC:4857]
ENSG00000158552	13.47	12.05	14.84	13.84	13.32	14.36	-0.0217913268568843	4.04014818178787	0.807184849623935	0.957071882546748	2:219195236-219209651:+	ZFAND2B	5;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0006616,biological_process SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger AN1-type containing 2B [Source:HGNC Symbol%3BAcc:HGNC:25206]
ENSG00000188895	35.37	32.51	32.84	34.72	32.70	35.35	-0.016128882739896	6.08811339603908	0.807408857515773	0.957246050462588	17:40122297-40136916:+	MSL1	5;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016569,biological_process covalent chromatin modification;GO:0043984,biological_process histone H4-K16 acetylation;GO:0072487,cellular_component MSL complex	NA	male specific lethal 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:27905]
ENSG00000124116	17.36	17.38	14.64	17.87	16.27	16.58	-0.0309669450683341	3.57138190056271	0.807570076958899	0.957345751627429	20:45747943-45791932:-	WFDC3	5;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030414,molecular_function peptidase inhibitor activity	NA	WAP four-disulfide core domain 3 [Source:HGNC Symbol%3BAcc:HGNC:15957]
ENSG00000127980	13.28	13.36	14.30	13.97	13.62	14.20	-0.0166170846879544	5.73527981275915	0.807789400846449	0.957353098313436	7:92487019-92528531:-	PEX1	18;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0006625,biological_process protein targeting to peroxisome;GO:0006810,biological_process transport;GO:0007031,biological_process peroxisome organization;GO:0008022,molecular_function protein C-terminus binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016558,biological_process protein import into peroxisome matrix;GO:0032403,molecular_function protein complex binding;GO:0042623,molecular_function ATPase activity, coupled;GO:0060152,biological_process microtubule-based peroxisome localization;GO:0070062,cellular_component extracellular exosome	PEX1; peroxin-1; K13338	peroxisomal biogenesis factor 1 [Source:HGNC Symbol%3BAcc:HGNC:8850]
ENSG00000118260	21.31	21.18	23.95	22.65	22.28	23.13	-0.0207845402374681	4.6826014653404	0.807792380671279	0.957353098313436	2:207529736-207603431:+	CREB1	92;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000975,molecular_function regulatory region DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001225,molecular_function RNA polymerase II transcription coactivator binding;GO:0001666,biological_process response to hypoxia;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005719,cellular_component nuclear euchromatin;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0007568,biological_process aging;GO:0007595,biological_process lactation;GO:0007613,biological_process memory;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0008361,biological_process regulation of cell size;GO:0008542,biological_process visual learning;GO:0010033,biological_process response to organic substance;GO:0010629,biological_process negative regulation of gene expression;GO:0010944,biological_process negative regulation of transcription by competitive promoter binding;GO:0014823,biological_process response to activity;GO:0016032,biological_process viral process;GO:0019899,molecular_function enzyme binding;GO:0021983,biological_process pituitary gland development;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030544,molecular_function Hsp70 protein binding;GO:0030879,biological_process mammary gland development;GO:0032916,biological_process positive regulation of transforming growth factor beta3 production;GO:0033363,biological_process secretory granule organization;GO:0033762,biological_process response to glucagon;GO:0034670,biological_process chemotaxis to arachidonic acid;GO:0035035,molecular_function histone acetyltransferase binding;GO:0035094,biological_process response to nicotine;GO:0035497,molecular_function cAMP response element binding;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042493,biological_process response to drug;GO:0042752,biological_process regulation of circadian rhythm;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046887,biological_process positive regulation of hormone secretion;GO:0046889,biological_process positive regulation of lipid biosynthetic process;GO:0048145,biological_process regulation of fibroblast proliferation;GO:0048511,biological_process rhythmic process;GO:0050821,biological_process protein stabilization;GO:0055025,biological_process positive regulation of cardiac muscle tissue development;GO:0060251,biological_process regulation of glial cell proliferation;GO:0060428,biological_process lung epithelium development;GO:0060430,biological_process lung saccule development;GO:0060509,biological_process Type I pneumocyte differentiation;GO:0071294,biological_process cellular response to zinc ion;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071398,biological_process cellular response to fatty acid;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1900273,biological_process positive regulation of long-term synaptic potentiation;GO:1901215,biological_process negative regulation of neuron death;GO:1902065,biological_process response to L-glutamate;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990314,biological_process cellular response to insulin-like growth factor stimulus;GO:1990589,cellular_component ATF4-CREB1 transcription factor complex;GO:1990763,molecular_function arrestin family protein binding;GO:1990830,biological_process cellular response to leukemia inhibitory factor	CREB1; cyclic AMP-responsive element-binding protein 1; K05870	cAMP responsive element binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:2345]
ENSG00000160959	5.83	6.53	8.26	6.68	7.95	6.75	-0.0384262769179896	3.39428408394964	0.807808742644223	0.957353098313436	8:144517991-144525178:+	LRRC14	NA	NA	leucine rich repeat containing 14 [Source:HGNC Symbol%3BAcc:HGNC:20419]
ENSG00000198000	21.08	20.61	21.50	21.44	20.69	22.29	-0.0156618396719482	6.28630791096938	0.807936408458094	0.957353098313436	9:92297357-92325636:-	NOL8	7;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:1902570,biological_process protein localization to nucleolus	NA	nucleolar protein 8 [Source:HGNC Symbol%3BAcc:HGNC:23387]
ENSG00000164306	9.54	7.62	9.24	9.58	8.35	9.29	-0.0223118623295411	3.93000057866227	0.80796189945473	0.957353098313436	4:184649612-184694963:+	PRIMPOL	19;GO:0003682,molecular_function chromatin binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0003896,molecular_function DNA primase activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006264,biological_process mitochondrial DNA replication;GO:0006269,biological_process DNA replication, synthesis of RNA primer;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0009411,biological_process response to UV;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019985,biological_process translesion synthesis;GO:0030145,molecular_function manganese ion binding;GO:0031297,biological_process replication fork processing;GO:0032774,biological_process RNA biosynthetic process	NA	primase and DNA directed polymerase [Source:HGNC Symbol%3BAcc:HGNC:26575]
ENSG00000137834	2.14	2.53	2.80	1.69	3.18	2.99	-0.0658190256307097	2.04144611507588	0.808365093937648	0.957739420735709	15:66702227-66782848:+	SMAD6	49;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001657,biological_process ureteric bud development;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003170,biological_process heart valve development;GO:0003183,biological_process mitral valve morphogenesis;GO:0003184,biological_process pulmonary valve morphogenesis;GO:0003281,biological_process ventricular septum development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006955,biological_process immune response;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007352,biological_process zygotic specification of dorsal/ventral axis;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010991,biological_process negative regulation of SMAD protein complex assembly;GO:0016604,cellular_component nuclear body;GO:0030279,biological_process negative regulation of ossification;GO:0030509,biological_process BMP signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514,biological_process negative regulation of BMP signaling pathway;GO:0030617,molecular_function transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity;GO:0031589,biological_process cell-substrate adhesion;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034616,biological_process response to laminar fluid shear stress;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0035904,biological_process aorta development;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043627,biological_process response to estrogen;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045444,biological_process fat cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0060394,biological_process negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0060976,biological_process coronary vasculature development;GO:0070410,molecular_function co-SMAD binding;GO:0070411,molecular_function I-SMAD binding;GO:0070412,molecular_function R-SMAD binding;GO:0070698,molecular_function type I activin receptor binding;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter	SMAD6; mothers against decapentaplegic homolog 6; K04677	SMAD family member 6 [Source:HGNC Symbol%3BAcc:HGNC:6772]
ENSG00000043514	24.47	21.03	23.40	23.35	22.21	25.03	-0.0183907915164874	5.10702988061888	0.808797137704614	0.958073130282482	1:39841021-39883511:-	TRIT1	16;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0004161,molecular_function dimethylallyltranstransferase activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006400,biological_process tRNA modification;GO:0008033,biological_process tRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding;GO:0052381,molecular_function tRNA dimethylallyltransferase activity;GO:0070900,biological_process mitochondrial tRNA modification	NA	tRNA isopentenyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:20286]
ENSG00000081307	33.12	32.78	34.45	33.78	33.54	32.69	0.0181007397530976	5.37712813032285	0.808898997966704	0.958073130282482	3:132654445-132678097:+	UBA5	14;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008641,molecular_function small protein activating enzyme activity;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0071566,molecular_function UFM1 activating enzyme activity;GO:0071569,biological_process protein ufmylation;GO:1990592,biological_process protein K69-linked ufmylation	NA	ubiquitin like modifier activating enzyme 5 [Source:HGNC Symbol%3BAcc:HGNC:23230]
ENSG00000156471	79.87	82.39	80.22	82.13	83.48	81.38	-0.0153253213385793	7.02067132539819	0.809007496217729	0.958073130282482	8:96261714-96336995:+	PTDSS1	8;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006659,biological_process phosphatidylserine biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity	PTDSS1; phosphatidylserine synthase 1 [EC:2.7.8.-]; K08729	phosphatidylserine synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:9587]
ENSG00000162408	8.08	8.44	8.67	8.96	7.96	8.05	0.0240435371038874	4.15024427675396	0.809023087906481	0.958073130282482	1:6521346-6554535:-	NOL9	16;GO:0000166,molecular_function nucleotide binding;GO:0000448,biological_process cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000460,biological_process maturation of 5.8S rRNA;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051731,molecular_function polynucleotide 5'-hydroxyl-kinase activity	NA	nucleolar protein 9 [Source:HGNC Symbol%3BAcc:HGNC:26265]
ENSG00000239521	5.36	6.04	4.53	4.61	6.83	3.89	0.0618155843322571	1.77560952811648	0.809098183052589	0.958073130282482	7:100200652-100272218:-	GATS	NA	NA	GATS%2C stromal antigen 3 opposite strand [Source:HGNC Symbol%3BAcc:HGNC:29954]
ENSG00000197296	8.36	7.17	8.80	7.91	7.91	8.05	0.0505660744315133	2.69892988555129	0.809109854567894	0.958073130282482	20:44302837-44311169:-	FITM2	16;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007010,biological_process cytoskeleton organization;GO:0008654,biological_process phospholipid biosynthetic process;GO:0010866,biological_process regulation of triglyceride biosynthetic process;GO:0010890,biological_process positive regulation of sequestering of triglyceride;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019915,biological_process lipid storage;GO:0022604,biological_process regulation of cell morphogenesis;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030730,biological_process sequestering of triglyceride;GO:0034389,biological_process lipid particle organization;GO:0035356,biological_process cellular triglyceride homeostasis	NA	fat storage inducing transmembrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16135]
ENSG00000164105	27.93	26.79	30.89	28.02	25.05	31.75	0.0266558050377883	4.24396203516176	0.809337561452216	0.958251349704918	4:173369968-173377532:+	SAP30	13;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016575,biological_process histone deacetylation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0046872,molecular_function metal ion binding	NA	Sin3A associated protein 30 [Source:HGNC Symbol%3BAcc:HGNC:10532]
ENSG00000180776	11.01	9.85	10.35	8.39	11.76	10.65	0.0353660761869195	3.54959633680006	0.809514929422345	0.958369939811118	13:21372572-21459370:-	ZDHHC20	8;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 20 [Source:HGNC Symbol%3BAcc:HGNC:20749]
ENSG00000123297	13.09	13.57	12.71	13.17	12.56	13.20	0.024168487146007	4.06108971714666	0.810417702559347	0.959296478672329	12:57782588-57808071:+	TSFM	12;GO:0003723,molecular_function RNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070129,biological_process regulation of mitochondrial translation	NA	Ts translation elongation factor%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:12367]
ENSG00000064115	52.08	54.56	49.64	49.36	60.92	49.51	-0.0209531091211705	6.61291297121997	0.810468556712747	0.959296478672329	12:26973194-27014434:-	TM7SF3	6;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	transmembrane 7 superfamily member 3 [Source:HGNC Symbol%3BAcc:HGNC:23049]
ENSG00000186976	1.24	0.95	1.41	1.09	1.22	1.22	0.0574498947189299	2.48322985266807	0.810529402103873	0.959296478672329	22:43528743-43812337:-	EFCAB6	6;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	EF-hand calcium binding domain 6 [Source:HGNC Symbol%3BAcc:HGNC:24204]
ENSG00000142252	29.83	29.67	34.08	31.24	30.68	34.35	-0.027367391608965	3.65747718027615	0.810900282126083	0.959386403110579	19:45079194-45091524:+	GEMIN7	14;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0097504,cellular_component Gemini of coiled bodies	GEMIN7, SIP3; gem associated protein 7; K13135	gem nuclear organelle associated protein 7 [Source:HGNC Symbol%3BAcc:HGNC:20045]
ENSG00000156172	7.85	6.46	9.24	9.16	7.45	6.34	0.0646594605141248	2.3185436342813	0.810924953427657	0.959386403110579	8:95244918-95269201:-	C8orf37	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0030054,cellular_component cell junction;GO:0097546,cellular_component ciliary base	NA	chromosome 8 open reading frame 37 [Source:HGNC Symbol%3BAcc:HGNC:27232]
ENSG00000165629	272.32	289.47	257.81	264.35	294.98	256.84	0.0172494982130883	7.93223782558029	0.811118450920355	0.959386403110579	10:7788128-7807815:+	ATP5C1	22;GO:0000275,cellular_component mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005759,cellular_component mitochondrial matrix;GO:0006119,biological_process oxidative phosphorylation;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0043209,cellular_component myelin sheath;GO:0045261,cellular_component proton-transporting ATP synthase complex, catalytic core F(1);GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF1G, ATP5C1, ATP3; F-type H+-transporting ATPase subunit gamma; K02136	ATP synthase%2C H+ transporting%2C mitochondrial F1 complex%2C gamma polypeptide 1 [Source:HGNC Symbol%3BAcc:HGNC:833]
ENSG00000168807	5.52	5.29	5.66	5.21	5.74	5.28	0.0379187704420521	3.17283563806189	0.811122053582872	0.959386403110579	16:69187128-69309052:+	SNTB2	17;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005925,cellular_component focal adhesion;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0030658,cellular_component transport vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043234,cellular_component protein complex;GO:0045202,cellular_component synapse;GO:0070062,cellular_component extracellular exosome	NA	syntrophin beta 2 [Source:HGNC Symbol%3BAcc:HGNC:11169]
ENSG00000182324	1.57	0.44	0.62	0.52	1.16	0.81	0.134484719360667	0.368309402568567	0.81127067354952	0.959386403110579	19:48455508-48466980:+	KCNJ14	14;GO:0005242,molecular_function inward rectifier potassium channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0010107,biological_process potassium ion import;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0043025,cellular_component neuronal cell body;GO:0061337,biological_process cardiac conduction	KCNJ14, KIR2.4; potassium inwardly-rectifying channel subfamily J member 14; K05007	potassium voltage-gated channel subfamily J member 14 [Source:HGNC Symbol%3BAcc:HGNC:6260]
ENSG00000213471	0.11	0.43	0.30	0.46	0.15	0.14	0.119833227688438	-0.347462893440434	0.811304745259835	0.959386403110579	15:90249529-90265482:+	TTLL13P	8;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0006464,biological_process cellular protein modification process;GO:0016874,molecular_function ligase activity;GO:0018095,biological_process protein polyglutamylation;GO:0070740,molecular_function tubulin-glutamic acid ligase activity	NA	tubulin tyrosine ligase like 13%2C pseudogene [Source:HGNC Symbol%3BAcc:HGNC:32484]
ENSG00000115221	3.67	4.33	2.65	3.17	4.20	2.97	0.0447809678473342	3.06288436431748	0.811332497029636	0.959386403110579	2:160099665-160271888:-	ITGB6	23;GO:0001618,molecular_function virus receptor activity;GO:0004872,molecular_function receptor activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0034685,cellular_component integrin alphav-beta6 complex;GO:0038044,biological_process transforming growth factor-beta secretion;GO:0043235,cellular_component receptor complex;GO:0046718,biological_process viral entry into host cell;GO:0070062,cellular_component extracellular exosome	ITGB6; integrin beta 6; K06589	integrin subunit beta 6 [Source:HGNC Symbol%3BAcc:HGNC:6161]
ENSG00000125656	44.36	44.05	46.14	46.94	45.09	45.36	-0.017106200522178	5.24224251037021	0.811443198733575	0.959386403110579	19:6361451-6368908:+	CLPP	12;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009368,cellular_component endopeptidase Clp complex;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0051260,biological_process protein homooligomerization;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process	clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]; K01358	caseinolytic mitochondrial matrix peptidase proteolytic subunit [Source:HGNC Symbol%3BAcc:HGNC:2084]
ENSG00000171806	10.25	8.14	9.63	8.59	10.53	8.51	0.0436645115029183	3.39791142055149	0.811655251576959	0.959386403110579	1:169792528-169794966:-	METTL18	7;GO:0005515,molecular_function protein binding;GO:0008150,biological_process biological_process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031072,molecular_function heat shock protein binding;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex	NA	methyltransferase like 18 [Source:HGNC Symbol%3BAcc:HGNC:28793]
ENSG00000119042	6.11	6.13	5.51	6.38	5.00	6.11	0.0290565578416922	3.72819272545344	0.811728067457196	0.959386403110579	2:199269499-199471266:-	SATB2	30;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001764,biological_process neuron migration;GO:0002076,biological_process osteoblast development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009880,biological_process embryonic pattern specification;GO:0010468,biological_process regulation of gene expression;GO:0016363,cellular_component nuclear matrix;GO:0016569,biological_process covalent chromatin modification;GO:0021902,biological_process commitment of neuronal cell to specific neuron type in forebrain;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0051216,biological_process cartilage development;GO:0060021,biological_process palate development;GO:0071310,biological_process cellular response to organic substance	NA	SATB homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:21637]
ENSG00000135835	0.83	0.81	0.88	0.82	0.83	0.80	0.0573197633269509	1.70845132998992	0.811754170961015	0.959386403110579	1:180913153-180951614:+	KIAA1614	NA	NA	KIAA1614 [Source:HGNC Symbol%3BAcc:HGNC:29327]
ENSG00000029363	29.94	34.65	29.02	30.52	34.82	30.29	-0.0212656282337773	6.53255975776264	0.811787508051446	0.959386403110579	6:136256626-136289851:-	BCLAF1	17;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0016607,cellular_component nuclear speck;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043620,biological_process regulation of DNA-templated transcription in response to stress;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000144,biological_process positive regulation of DNA-templated transcription, initiation;GO:2001022,biological_process positive regulation of response to DNA damage stimulus;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	NA	BCL2 associated transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:16863]
ENSG00000213563	15.48	15.56	15.48	13.18	14.62	18.14	0.0275453220879113	4.14425232745072	0.811815022389008	0.959386403110579	8:144525732-144529132:-	C8orf82	NA	NA	chromosome 8 open reading frame 82 [Source:HGNC Symbol%3BAcc:HGNC:33826]
ENSG00000129197	48.16	46.59	44.67	47.83	45.72	45.22	0.0189403889945259	5.06829380587009	0.812055755057827	0.959386403110579	17:5419640-5432876:+	RPAIN	10;GO:0001650,cellular_component fibrillar center;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006606,biological_process protein import into nucleus;GO:0016605,cellular_component PML body;GO:0032403,molecular_function protein complex binding;GO:0046872,molecular_function metal ion binding	NA	RPA interacting protein [Source:HGNC Symbol%3BAcc:HGNC:28641]
ENSG00000182774	464.88	415.99	390.52	437.45	406.20	454.07	-0.0176518668247612	8.18748945628554	0.812069787585176	0.959386403110579	15:82536752-82540564:-	RPS17	21;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0034101,biological_process erythrocyte homeostasis;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0070062,cellular_component extracellular exosome	RP-S17e, RPS17; small subunit ribosomal protein S17e; K02962	ribosomal protein S17 [Source:HGNC Symbol%3BAcc:HGNC:10397]
ENSG00000103266	105.64	98.85	95.60	100.30	102.47	103.21	-0.0156675591152884	6.60292992388658	0.812084287273031	0.959386403110579	16:680223-682870:+	STUB1	51;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0030018,cellular_component Z disc;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030544,molecular_function Hsp70 protein binding;GO:0030579,biological_process ubiquitin-dependent SMAD protein catabolic process;GO:0030674,molecular_function protein binding, bridging;GO:0030911,molecular_function TPR domain binding;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031371,cellular_component ubiquitin conjugating enzyme complex;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0031943,biological_process regulation of glucocorticoid metabolic process;GO:0032091,biological_process negative regulation of protein binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042405,cellular_component nuclear inclusion body;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0046332,molecular_function SMAD binding;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0051604,biological_process protein maturation;GO:0051787,molecular_function misfolded protein binding;GO:0051865,biological_process protein autoubiquitination;GO:0051879,molecular_function Hsp90 protein binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0071218,biological_process cellular response to misfolded protein;GO:0090035,biological_process positive regulation of chaperone-mediated protein complex assembly;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway	STUB1, CHIP; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]; K09561	STIP1 homology and U-box containing protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11427]
ENSG00000106266	35.43	35.73	35.15	37.93	35.75	34.75	-0.0167381562193169	5.69939121292479	0.812099317625931	0.959386403110579	7:2251769-2354318:-	SNX8	17;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0019898,cellular_component extrinsic component of membrane;GO:0030904,cellular_component retromer complex;GO:0031901,cellular_component early endosome membrane;GO:0034498,biological_process early endosome to Golgi transport;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	sorting nexin 8 [Source:HGNC Symbol%3BAcc:HGNC:14972]
ENSG00000164252	11.53	11.30	10.05	10.57	11.16	11.90	-0.0234836829047843	4.71319991323494	0.812137227753186	0.959386403110579	5:77029250-77065234:+	AGGF1	12;GO:0001525,biological_process angiogenesis;GO:0001570,biological_process vasculogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	angiogenic factor with G-patch and FHA domains 1 [Source:HGNC Symbol%3BAcc:HGNC:24684]
ENSG00000168769	3.58	4.19	4.07	4.06	3.83	4.20	-0.0259209060543029	4.62590117723119	0.81214430361149	0.959386403110579	4:105145874-105279816:+	TET2	18;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0006211,biological_process 5-methylcytosine catabolic process;GO:0006493,biological_process protein O-linked glycosylation;GO:0007049,biological_process cell cycle;GO:0008198,molecular_function ferrous iron binding;GO:0008270,molecular_function zinc ion binding;GO:0014070,biological_process response to organic cyclic compound;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0030099,biological_process myeloid cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070579,molecular_function methylcytosine dioxygenase activity;GO:0080111,biological_process DNA demethylation;GO:0080182,biological_process histone H3-K4 trimethylation	NA	tet methylcytosine dioxygenase 2 [Source:HGNC Symbol%3BAcc:HGNC:25941]
ENSG00000172465	17.03	21.44	22.68	22.29	20.19	17.54	0.0350052480688822	3.2862536445263	0.812169445130482	0.959386403110579	X:103628703-103630953:+	TCEAL1	7;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0050699,molecular_function WW domain binding	NA	transcription elongation factor A like 1 [Source:HGNC Symbol%3BAcc:HGNC:11616]
ENSG00000183172	53.46	49.42	45.40	52.71	50.09	44.03	0.0283606572286407	3.99478096741993	0.812228446812944	0.959386403110579	22:42079690-42084284:+	SMDT1	15;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:1990246,cellular_component uniplex complex	NA	single-pass membrane protein with aspartate rich tail 1 [Source:HGNC Symbol%3BAcc:HGNC:25055]
ENSG00000172115	341.92	392.88	340.90	363.90	385.95	347.57	-0.0191019529515404	6.83566977623999	0.812526313401742	0.959646919910164	7:25120090-25125361:-	CYCS	23;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0006470,biological_process protein dephosphorylation;GO:0006915,biological_process apoptotic process;GO:0007005,biological_process mitochondrion organization;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0009055,molecular_function electron carrier activity;GO:0020037,molecular_function heme binding;GO:0034599,biological_process cellular response to oxidative stress;GO:0045155,molecular_function electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity;GO:0045333,biological_process cellular respiration;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:0097193,biological_process intrinsic apoptotic signaling pathway	CYC; cytochrome c; K08738	cytochrome c%2C somatic [Source:HGNC Symbol%3BAcc:HGNC:19986]
ENSG00000170537	0.88	0.49	0.66	0.80	0.45	0.69	0.0965373144497303	0.783636814019949	0.812723194805291	0.959788128352971	16:18983933-19063942:+	TMC7	4;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane channel like 7 [Source:HGNC Symbol%3BAcc:HGNC:23000]
ENSG00000077463	15.91	18.06	16.31	16.10	17.51	16.11	0.0217223672933416	4.17141681005576	0.81296964233335	0.959858872352039	19:4174108-4182604:-	SIRT6	40;GO:0003247,biological_process post-embryonic cardiac muscle cell growth involved in heart morphogenesis;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0003956,molecular_function NAD(P)+-protein-arginine ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005724,cellular_component nuclear telomeric heterochromatin;GO:0005737,cellular_component cytoplasm;GO:0006284,biological_process base-excision repair;GO:0006471,biological_process protein ADP-ribosylation;GO:0006476,biological_process protein deacetylation;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0017136,molecular_function NAD-dependent histone deacetylase activity;GO:0031648,biological_process protein destabilization;GO:0031667,biological_process response to nutrient levels;GO:0031940,biological_process positive regulation of chromatin silencing at telomere;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0033558,molecular_function protein deacetylase activity;GO:0034979,molecular_function NAD-dependent protein deacetylase activity;GO:0042593,biological_process glucose homeostasis;GO:0045820,biological_process negative regulation of glycolytic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046325,biological_process negative regulation of glucose import;GO:0046872,molecular_function metal ion binding;GO:0046969,molecular_function NAD-dependent histone deacetylase activity (H3-K9 specific);GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0061647,biological_process histone H3-K9 modification;GO:0070403,molecular_function NAD+ binding;GO:1902732,biological_process positive regulation of chondrocyte proliferation;GO:1905549,biological_process positive regulation of telomeric heterochromatin assembly;GO:1905555,biological_process positive regulation blood vessel branching;GO:1905564,biological_process positive regulation of vascular endothelial cell proliferation;GO:1990619,biological_process histone H3-K9 deacetylation;GO:2000648,biological_process positive regulation of stem cell proliferation	SIRT6, SIR2L6; NAD+-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]; K11416	sirtuin 6 [Source:HGNC Symbol%3BAcc:HGNC:14934]
ENSG00000164168	13.99	14.36	12.56	13.86	14.50	13.55	-0.0267257904543615	4.19632322192997	0.813031636723748	0.959858872352039	4:147617382-147672044:+	TMEM184C	4;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 184C [Source:HGNC Symbol%3BAcc:HGNC:25587]
ENSG00000101000	38.59	43.80	38.83	41.26	44.29	38.26	-0.0229147946911785	5.12358130772907	0.813061759202222	0.959858872352039	20:35172072-35216240:+	PROCR	15;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005813,cellular_component centrosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050819,biological_process negative regulation of coagulation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome	PROCR, CD201; protein C receptor, endothelial (EPCR); K06557	protein C receptor [Source:HGNC Symbol%3BAcc:HGNC:9452]
ENSG00000109466	9.33	9.08	10.79	10.09	10.42	9.51	-0.0225033927584576	4.27092653719514	0.813097459521336	0.959858872352039	4:165207617-165323156:+	KLHL2	17;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0030027,cellular_component lamellipodium;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043687,biological_process post-translational protein modification	NA	kelch like family member 2 [Source:HGNC Symbol%3BAcc:HGNC:6353]
ENSG00000149262	9.86	10.33	11.29	10.46	10.34	11.40	-0.0209855471313904	4.99102844502705	0.813332810893317	0.959858872352039	11:77878719-77994678:-	INTS4	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016180,biological_process snRNA processing;GO:0032039,cellular_component integrator complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter	NA	integrator complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:25048]
ENSG00000108039	29.30	26.40	26.67	26.79	27.44	29.88	-0.0168145414641525	5.79897003330029	0.813337787650383	0.959858872352039	10:109864765-109923553:-	XPNPEP1	13;GO:0004177,molecular_function aminopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0010815,biological_process bradykinin catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome	NA	X-prolyl aminopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:12822]
ENSG00000136732	143.27	150.57	159.09	158.71	136.87	167.19	-0.0201461381372858	5.87795861971532	0.813474200792571	0.959858872352039	2:126655932-126696675:+	GYPC	15;GO:0004872,molecular_function receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008037,biological_process cell recognition;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030863,cellular_component cortical cytoskeleton;GO:0042803,molecular_function protein homodimerization activity;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050900,biological_process leukocyte migration	GYPC, CD236; glycophorin C; K06576	glycophorin C (Gerbich blood group) [Source:HGNC Symbol%3BAcc:HGNC:4704]
ENSG00000187024	4.94	7.19	5.87	5.30	5.64	6.55	0.033851665620158	2.74660133873815	0.813481119303917	0.959858872352039	9:127690347-127724873:-	PTRH1	5;GO:0003723,molecular_function RNA binding;GO:0004045,molecular_function aminoacyl-tRNA hydrolase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0016787,molecular_function hydrolase activity	NA	peptidyl-tRNA hydrolase 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:27039]
ENSG00000111684	42.62	53.35	39.42	41.65	50.01	42.34	0.0234497040689092	6.07691360697297	0.813503468133541	0.959858872352039	12:6976185-7018510:-	LPCAT3	16;GO:0003841,molecular_function 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0047144,molecular_function 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184,molecular_function 1-acylglycerophosphocholine O-acyltransferase activity;GO:0097006,biological_process regulation of plasma lipoprotein particle levels	LPCAT3, MBOAT5; lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-]; K13515	lysophosphatidylcholine acyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:30244]
ENSG00000235173	7.85	7.02	6.86	7.74	6.61	7.09	0.0342327545409121	3.10189937930438	0.813556368002562	0.959858872352039	8:144137768-144140843:+	HGH1	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	HGH1 homolog [Source:HGNC Symbol%3BAcc:HGNC:24161]
ENSG00000196739	21.31	21.45	21.68	21.34	22.52	21.78	-0.0148068920587576	6.94353930458612	0.813789027043218	0.960042120574745	9:114155559-114312511:+	COL27A1	9;GO:0003431,biological_process growth plate cartilage chondrocyte development;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005583,cellular_component fibrillar collagen trimer;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0030198,biological_process extracellular matrix organization;GO:0046872,molecular_function metal ion binding	COL1A; collagen, type I, alpha; K06236	collagen type XXVII alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:22986]
ENSG00000228672	1.44	1.41	1.69	1.50	1.54	1.69	-0.0426602614080959	2.28522440962287	0.813879409269447	0.960049992435054	5:139390591-139395713:-	PROB1	NA	NA	proline rich basic protein 1 [Source:HGNC Symbol%3BAcc:HGNC:41906]
ENSG00000188266	1.20	1.63	1.50	1.66	1.36	1.62	-0.101128298328096	0.926405333223663	0.813950384305688	0.960049992435054	15:78507563-78537372:+	HYKK	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0006554,biological_process lysine catabolic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0047992,molecular_function hydroxylysine kinase activity	NA	hydroxylysine kinase [Source:HGNC Symbol%3BAcc:HGNC:34403]
ENSG00000133065	14.41	16.08	16.02	15.37	17.35	14.90	-0.02412865231392	4.60161156358679	0.814437862834293	0.960221740546392	1:205789092-205813748:-	SLC41A1	19;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0010961,biological_process cellular magnesium ion homeostasis;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0022892,molecular_function substrate-specific transporter activity;GO:0035725,biological_process sodium ion transmembrane transport;GO:0043234,cellular_component protein complex;GO:0061768,molecular_function magnesium:sodium antiporter activity;GO:0070838,biological_process divalent metal ion transport;GO:0071286,biological_process cellular response to magnesium ion;GO:0072509,molecular_function divalent inorganic cation transmembrane transporter activity;GO:1903830,biological_process magnesium ion transmembrane transport	NA	solute carrier family 41 member 1 [Source:HGNC Symbol%3BAcc:HGNC:19429]
ENSG00000150977	14.95	12.53	10.81	11.35	14.14	14.22	-0.0384582681506051	3.07113255949927	0.814601019509769	0.960221740546392	12:123410682-123436717:-	RILPL2	19;GO:0003382,biological_process epithelial cell morphogenesis;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0031267,molecular_function small GTPase binding;GO:0036064,cellular_component ciliary basal body;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0046983,molecular_function protein dimerization activity;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:1903445,biological_process protein transport from ciliary membrane to plasma membrane	NA	Rab interacting lysosomal protein like 2 [Source:HGNC Symbol%3BAcc:HGNC:28787]
ENSG00000162688	8.46	8.91	7.64	8.10	9.46	8.01	-0.0223563829312306	5.32499635135143	0.814625217575747	0.960221740546392	1:99850083-99924023:+	AGL	30;GO:0003824,molecular_function catalytic activity;GO:0004133,molecular_function glycogen debranching enzyme activity;GO:0004134,molecular_function 4-alpha-glucanotransferase activity;GO:0004135,molecular_function amylo-alpha-1,6-glucosidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0005980,biological_process glycogen catabolic process;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0009725,biological_process response to hormone;GO:0016234,cellular_component inclusion body;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0030246,molecular_function carbohydrate binding;GO:0030247,molecular_function polysaccharide binding;GO:0031593,molecular_function polyubiquitin binding;GO:0034774,cellular_component secretory granule lumen;GO:0043033,cellular_component isoamylase complex;GO:0043312,biological_process neutrophil degranulation;GO:0051384,biological_process response to glucocorticoid;GO:0102500,molecular_function beta-maltose 4-alpha-glucanotransferase activity;GO:1904813,cellular_component ficolin-1-rich granule lumen	AGL; glycogen debranching enzyme [EC:2.4.1.25 3.2.1.33]; K01196	amylo-alpha-1%2C 6-glucosidase%2C 4-alpha-glucanotransferase [Source:HGNC Symbol%3BAcc:HGNC:321]
ENSG00000164010	8.52	8.11	11.16	9.09	11.07	8.64	-0.0320313547011909	3.76890592335182	0.814653620920059	0.960221740546392	1:42817123-42844989:+	ERMAP	4;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	erythroblast membrane associated protein (Scianna blood group) [Source:HGNC Symbol%3BAcc:HGNC:15743]
ENSG00000173465	17.79	16.73	15.76	16.22	17.67	17.80	-0.0278629729495799	3.77215501966329	0.814698326858804	0.960221740546392	11:65570429-65573942:+	SSSCA1	5;GO:0000278,biological_process mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0007049,biological_process cell cycle;GO:0042802,molecular_function identical protein binding;GO:0051301,biological_process cell division	NA	Sjogren syndrome/scleroderma autoantigen 1 [Source:HGNC Symbol%3BAcc:HGNC:11328]
ENSG00000115145	14.57	13.47	13.97	14.69	14.49	13.84	-0.0181656568835198	4.49240004974306	0.814804694657939	0.960221740546392	2:152116800-152175992:-	STAM2	18;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016579,biological_process protein deubiquitination;GO:0031901,cellular_component early endosome membrane;GO:0033565,cellular_component ESCRT-0 complex;GO:0036258,biological_process multivesicular body assembly;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0061024,biological_process membrane organization	STAM; signal transducing adaptor molecule; K04705	signal transducing adaptor molecule 2 [Source:HGNC Symbol%3BAcc:HGNC:11358]
ENSG00000172780	11.49	12.33	14.45	11.66	14.15	13.81	-0.0369851787820665	3.23598440454613	0.814911677305408	0.960221740546392	3:129087568-129122801:-	RAB43	17;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0007030,biological_process Golgi organization;GO:0016020,cellular_component membrane;GO:0019068,biological_process virion assembly;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0035526,biological_process retrograde transport, plasma membrane to Golgi;GO:0045335,cellular_component phagocytic vesicle;GO:0070062,cellular_component extracellular exosome;GO:0090382,biological_process phagosome maturation;GO:1901998,biological_process toxin transport	NA	RAB43%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:19983]
ENSG00000215193	12.21	11.61	12.65	12.80	11.67	13.04	-0.0262534583990532	3.79533666673486	0.815017146314514	0.960221740546392	22:18077919-18131138:+	PEX26	13;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0006810,biological_process transport;GO:0008022,molecular_function protein C-terminus binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016558,biological_process protein import into peroxisome matrix;GO:0032403,molecular_function protein complex binding;GO:0045046,biological_process protein import into peroxisome membrane;GO:0051117,molecular_function ATPase binding	PEX26; peroxin-26; K13340	peroxisomal biogenesis factor 26 [Source:HGNC Symbol%3BAcc:HGNC:22965]
ENSG00000151655	1.12	1.08	0.73	1.11	0.96	1.02	-0.0737689948330668	1.58012104582182	0.815114624717904	0.960221740546392	10:7703268-7749520:+	ITIH2	12;GO:0004866,molecular_function endopeptidase inhibitor activity;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005576,cellular_component extracellular region;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0010466,biological_process negative regulation of peptidase activity;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0030212,biological_process hyaluronan metabolic process;GO:0030414,molecular_function peptidase inhibitor activity;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0072562,cellular_component blood microparticle	NA	inter-alpha-trypsin inhibitor heavy chain 2 [Source:HGNC Symbol%3BAcc:HGNC:6167]
ENSG00000170734	14.40	13.27	15.14	14.21	14.64	14.96	-0.017223462910924	4.95871500800656	0.815149761637013	0.960221740546392	6:43576149-43615660:+	POLH	22;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006282,biological_process regulation of DNA repair;GO:0006290,biological_process pyrimidine dimer repair;GO:0006301,biological_process postreplication repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010225,biological_process response to UV-C;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019985,biological_process translesion synthesis;GO:0046872,molecular_function metal ion binding;GO:0070987,biological_process error-free translesion synthesis;GO:0071494,biological_process cellular response to UV-C;GO:0071897,biological_process DNA biosynthetic process	POLH; DNA polymerase eta [EC:2.7.7.7]; K03509	DNA polymerase eta [Source:HGNC Symbol%3BAcc:HGNC:9181]
ENSG00000185043	155.42	145.62	149.11	152.66	145.99	150.58	0.0156868930428885	6.70219668220572	0.815193692986693	0.960221740546392	15:90229974-90234047:-	CIB1	81;GO:0001525,biological_process angiogenesis;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002931,biological_process response to ischemia;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006302,biological_process double-strand break repair;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007049,biological_process cell cycle;GO:0007113,biological_process endomitotic cell cycle;GO:0007155,biological_process cell adhesion;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0008022,molecular_function protein C-terminus binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008427,molecular_function calcium-dependent protein kinase inhibitor activity;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017016,molecular_function Ras GTPase binding;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030154,biological_process cell differentiation;GO:0030220,biological_process platelet formation;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031982,cellular_component vesicle;GO:0032433,cellular_component filopodium tip;GO:0032587,cellular_component ruffle membrane;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0038163,biological_process thrombopoietin-mediated signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042383,cellular_component sarcolemma;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043495,molecular_function protein anchor;GO:0044325,molecular_function ion channel binding;GO:0045653,biological_process negative regulation of megakaryocyte differentiation;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051301,biological_process cell division;GO:0051302,biological_process regulation of cell division;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070886,biological_process positive regulation of calcineurin-NFAT signaling cascade;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0071944,cellular_component cell periphery;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0090050,biological_process positive regulation of cell migration involved in sprouting angiogenesis;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000256,biological_process positive regulation of male germ cell proliferation	NA	calcium and integrin binding 1 [Source:HGNC Symbol%3BAcc:HGNC:16920]
ENSG00000120594	1.82	2.83	2.46	2.88	2.34	2.17	-0.0605930143066739	1.98446921738417	0.815226815139396	0.960221740546392	10:19816238-20289856:+	PLXDC2	4;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	plexin domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:21013]
ENSG00000241839	2.11	1.63	2.40	2.04	1.96	2.01	0.0637920065108867	1.65619220698087	0.815246674380487	0.960221740546392	15:64841882-64868007:+	PLEKHO2	3;GO:0005576,cellular_component extracellular region;GO:0043312,biological_process neutrophil degranulation;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	pleckstrin homology domain containing O2 [Source:HGNC Symbol%3BAcc:HGNC:30026]
ENSG00000010327	0.69	0.61	0.68	0.65	0.65	0.63	0.0525139587775909	2.37268486308707	0.815258465705202	0.960221740546392	3:52495337-52524495:+	STAB1	19;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007267,biological_process cell-cell signaling;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030666,cellular_component endocytic vesicle membrane;GO:0042742,biological_process defense response to bacterium;GO:0055114,biological_process oxidation-reduction process	NA	stabilin 1 [Source:HGNC Symbol%3BAcc:HGNC:18628]
ENSG00000103495	105.64	102.51	102.04	105.76	109.01	101.13	-0.0143233187064246	7.78039395728409	0.815292529800088	0.960221740546392	16:29806105-29811164:+	MAZ	11;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0046872,molecular_function metal ion binding	NA	MYC associated zinc finger protein [Source:HGNC Symbol%3BAcc:HGNC:6914]
ENSG00000189091	47.14	53.41	46.08	47.47	52.54	45.91	0.0175505758490442	7.48043884349665	0.815333694139932	0.960221740546392	16:70523787-70577670:+	SF3B3	17;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005730,cellular_component nucleolus;GO:0006397,biological_process mRNA processing;GO:0006461,biological_process protein complex assembly;GO:0008380,biological_process RNA splicing;GO:0030532,cellular_component small nuclear ribonucleoprotein complex;GO:0032403,molecular_function protein complex binding;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0071013,cellular_component catalytic step 2 spliceosome	SF3B3, SAP130, RSE1; splicing factor 3B subunit 3; K12830	splicing factor 3b subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:10770]
ENSG00000155363	51.83	48.24	54.23	54.27	50.13	52.93	-0.0152264823105203	7.29093487424228	0.815554383277426	0.96039052837707	1:112673140-112700746:+	MOV10	19;GO:0000166,molecular_function nucleotide binding;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0016787,molecular_function hydrolase activity;GO:0031047,biological_process gene silencing by RNA;GO:0035195,biological_process gene silencing by miRNA;GO:0035279,biological_process mRNA cleavage involved in gene silencing by miRNA;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048015,biological_process phosphatidylinositol-mediated signaling	NA	Mov10 RISC complex RNA helicase [Source:HGNC Symbol%3BAcc:HGNC:7200]
ENSG00000120705	90.59	81.11	81.69	88.08	85.30	85.00	-0.0151420703052261	6.85605420408565	0.815632494064878	0.96039140095118	5:138506094-138543300:-	ETF1	13;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003747,molecular_function translation release factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006415,biological_process translational termination;GO:0006449,biological_process regulation of translational termination;GO:0006479,biological_process protein methylation;GO:0008079,molecular_function translation termination factor activity;GO:0043022,molecular_function ribosome binding;GO:1990825,molecular_function sequence-specific mRNA binding	ETF1, ERF1; peptide chain release factor subunit 1; K03265	eukaryotic translation termination factor 1 [Source:HGNC Symbol%3BAcc:HGNC:3477]
ENSG00000197771	35.97	31.66	35.39	36.58	32.41	36.25	-0.016349275413356	6.06871083207421	0.815883104706819	0.960595369318576	10:119829403-119892556:-	MCMBP	13;GO:0000790,cellular_component nuclear chromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0042555,cellular_component MCM complex;GO:0051301,biological_process cell division	NA	minichromosome maintenance complex binding protein [Source:HGNC Symbol%3BAcc:HGNC:25782]
ENSG00000141556	20.60	23.04	21.04	20.61	22.43	21.36	0.0153308944507757	6.39595151706148	0.816486455696001	0.961113396078939	17:82752063-82945922:+	TBCD	25;GO:0000278,biological_process mitotic cell cycle;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0005923,cellular_component bicellular tight junction;GO:0006457,biological_process protein folding;GO:0007021,biological_process tubulin complex assembly;GO:0007023,biological_process post-chaperonin tubulin folding pathway;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0030054,cellular_component cell junction;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0034333,biological_process adherens junction assembly;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048487,molecular_function beta-tubulin binding;GO:0048667,biological_process cell morphogenesis involved in neuron differentiation;GO:0051087,molecular_function chaperone binding;GO:0070830,biological_process bicellular tight junction assembly	NA	tubulin folding cofactor D [Source:HGNC Symbol%3BAcc:HGNC:11581]
ENSG00000163291	8.64	8.95	9.64	10.31	7.76	8.74	0.0349252200278595	3.25967138021638	0.816596383659493	0.961113396078939	4:78887126-78939438:-	PAQR3	11;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004872,molecular_function receptor activity;GO:0005794,cellular_component Golgi apparatus;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0043407,biological_process negative regulation of MAP kinase activity	NA	progestin and adipoQ receptor family member 3 [Source:HGNC Symbol%3BAcc:HGNC:30130]
ENSG00000073614	9.05	9.14	8.24	8.66	9.33	8.32	0.0177335685944341	5.52041206932408	0.816672923633728	0.961113396078939	12:280128-389454:-	KDM5A	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0008584,biological_process male gonad development;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0019907,cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0031490,molecular_function chromatin DNA binding;GO:0032452,molecular_function histone demethylase activity;GO:0032922,biological_process circadian regulation of gene expression;GO:0032993,cellular_component protein-DNA complex;GO:0034647,molecular_function histone demethylase activity (H3-trimethyl-K4 specific);GO:0034648,molecular_function histone demethylase activity (H3-dimethyl-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0034721,biological_process histone H3-K4 demethylation, trimethyl-H3-K4-specific;GO:0035064,molecular_function methylated histone binding;GO:0042393,molecular_function histone binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:1901726,biological_process negative regulation of histone deacetylase activity	NA	lysine demethylase 5A [Source:HGNC Symbol%3BAcc:HGNC:9886]
ENSG00000131773	38.85	40.36	39.85	36.69	43.16	38.61	0.0183463689928257	5.38128952531625	0.816718962430987	0.961113396078939	8:135457456-135656722:+	KHDRBS3	13;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0017124,molecular_function SH3 domain binding;GO:0019904,molecular_function protein domain specific binding;GO:0042802,molecular_function identical protein binding;GO:0048024,biological_process regulation of mRNA splicing, via spliceosome;GO:0051259,biological_process protein oligomerization	NA	KH RNA binding domain containing%2C signal transduction associated 3 [Source:HGNC Symbol%3BAcc:HGNC:18117]
ENSG00000198218	36.22	42.00	38.54	38.08	41.14	39.81	-0.0184966511940641	6.51886757509877	0.816940833695754	0.961113396078939	3:49029706-49094363:-	QRICH1	13;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process;GO:0022604,biological_process regulation of cell morphogenesis;GO:0042981,biological_process regulation of apoptotic process	NA	glutamine rich 1 [Source:HGNC Symbol%3BAcc:HGNC:24713]
ENSG00000114626	11.84	13.50	16.02	14.02	12.15	14.74	0.0267629885457344	4.35432541860592	0.817191342713736	0.961113396078939	3:127672934-127680920:+	ABTB1	13;GO:0003746,molecular_function translation elongation factor activity;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process	NA	ankyrin repeat and BTB domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18275]
ENSG00000250506	8.80	5.54	7.16	7.69	7.05	7.69	-0.0310991811257929	2.78947414932203	0.8171917991156	0.961113396078939	17:76000905-76005999:+	CDK3	26;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010033,biological_process response to organic substance;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010468,biological_process regulation of gene expression;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030332,molecular_function cyclin binding;GO:0045023,biological_process G0 to G1 transition;GO:0051301,biological_process cell division	NA	cyclin dependent kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:1772]
ENSG00000198879	2.41	2.04	2.59	2.47	2.31	2.52	-0.0301256810655263	2.76168788006214	0.817203550570248	0.961113396078939	10:7158623-7411486:-	SFMBT2	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010629,biological_process negative regulation of gene expression;GO:0016235,cellular_component aggresome;GO:0016607,cellular_component nuclear speck;GO:0042393,molecular_function histone binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	Scm-like with four mbt domains 2 [Source:HGNC Symbol%3BAcc:HGNC:20256]
ENSG00000132141	2.53	2.82	3.19	3.30	2.77	2.87	-0.0526170770528383	2.25960174566002	0.817251331115119	0.961113396078939	17:34927858-34981078:-	CCT6B	15;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0007283,biological_process spermatogenesis;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0044183,molecular_function protein binding involved in protein folding;GO:0051082,molecular_function unfolded protein binding;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0061077,biological_process chaperone-mediated protein folding;GO:1901998,biological_process toxin transport	NA	chaperonin containing TCP1 subunit 6B [Source:HGNC Symbol%3BAcc:HGNC:1621]
ENSG00000115446	67.47	59.18	64.09	65.37	62.65	66.77	-0.0150028038314789	5.77955767433362	0.817403386791089	0.961113396078939	2:98608578-98618515:+	UNC50	11;GO:0000139,cellular_component Golgi membrane;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030173,cellular_component integral component of Golgi membrane	NA	unc-50 inner nuclear membrane RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:16046]
ENSG00000182095	28.85	27.75	29.40	28.89	28.82	28.20	0.0139964174740795	8.02309855435577	0.817460349939358	0.961113396078939	7:5306789-5425414:-	TNRC18	10;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005677,cellular_component chromatin silencing complex;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006342,biological_process chromatin silencing;GO:0031507,biological_process heterochromatin assembly;GO:0031965,cellular_component nuclear membrane	NA	trinucleotide repeat containing 18 [Source:HGNC Symbol%3BAcc:HGNC:11962]
ENSG00000083817	5.63	4.99	4.92	5.21	5.15	4.97	0.0356382293791116	3.22230878353493	0.817551709908936	0.961113396078939	19:57571565-57578927:-	ZNF416	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 416 [Source:HGNC Symbol%3BAcc:HGNC:20645]
ENSG00000171681	9.23	8.81	9.43	9.32	10.09	8.68	-0.0173846550069092	5.18019751595535	0.817630574328182	0.961113396078939	12:14365631-14502935:+	ATF7IP	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005829,cellular_component cytosol;GO:0006306,biological_process DNA methylation;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016032,biological_process viral process;GO:0016604,cellular_component nuclear body;GO:0016887,molecular_function ATPase activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045898,biological_process regulation of RNA polymerase II transcriptional preinitiation complex assembly	NA	activating transcription factor 7 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:20092]
ENSG00000149179	27.84	30.15	29.90	29.94	31.63	28.12	-0.0188045877234493	5.37572516639262	0.817634140137338	0.961113396078939	11:46936688-47164385:+	C11orf49	1;GO:0005515,molecular_function protein binding	NA	chromosome 11 open reading frame 49 [Source:HGNC Symbol%3BAcc:HGNC:28720]
ENSG00000243667	14.24	14.54	11.55	13.28	13.53	13.00	0.0255244811862216	3.85120672046309	0.817638871459164	0.961113396078939	2:68122935-68157560:-	WDR92	3;GO:0005515,molecular_function protein binding;GO:0006915,biological_process apoptotic process;GO:0043130,molecular_function ubiquitin binding	NA	WD repeat domain 92 [Source:HGNC Symbol%3BAcc:HGNC:25176]
ENSG00000260456	2.84	2.52	2.14	2.70	2.63	2.63	-0.0720458792692322	1.00996399243214	0.817715545223654	0.961113396078939	16:87083561-87317420:-	C16orf95	NA	NA	chromosome 16 open reading frame 95 [Source:HGNC Symbol%3BAcc:HGNC:40033]
ENSG00000122042	25.15	22.33	23.28	20.05	25.71	23.84	0.0406242506903305	3.06719373836831	0.8178165071843	0.961113396078939	13:29764370-29850684:-	UBL3	4;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	NA	ubiquitin like 3 [Source:HGNC Symbol%3BAcc:HGNC:12504]
ENSG00000198855	1.01	1.15	1.14	1.12	1.00	1.05	0.0664192491888599	1.01946899942291	0.81787240033837	0.961113396078939	12:108515184-108525837:+	FICD	9;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0018117,biological_process protein adenylylation;GO:0034260,biological_process negative regulation of GTPase activity;GO:0070733,molecular_function protein adenylyltransferase activity	NA	FIC domain containing [Source:HGNC Symbol%3BAcc:HGNC:18416]
ENSG00000164916	12.48	11.54	11.43	13.06	10.95	12.29	-0.0210992883571798	4.72935993105451	0.817930722097486	0.961113396078939	7:4682308-4771443:+	FOXK1	18;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016579,biological_process protein deubiquitination;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	forkhead box K1 [Source:HGNC Symbol%3BAcc:HGNC:23480]
ENSG00000020129	13.61	13.06	11.94	12.69	12.85	13.93	-0.0210023006770968	4.86842306128527	0.818018163401513	0.961113396078939	1:35557472-35567274:+	NCDN	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0030425,cellular_component dendrite;GO:0031175,biological_process neuron projection development;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0045453,biological_process bone resorption;GO:0048168,biological_process regulation of neuronal synaptic plasticity	NA	neurochondrin [Source:HGNC Symbol%3BAcc:HGNC:17597]
ENSG00000152439	8.98	5.74	9.05	8.73	6.75	9.29	-0.0365779171689547	3.55093735548557	0.818052671266981	0.961113396078939	19:57499914-57518404:+	ZNF773	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 773 [Source:HGNC Symbol%3BAcc:HGNC:30487]
ENSG00000249709	5.62	5.31	4.36	4.59	5.05	5.38	0.0345086252381766	3.29162530470673	0.818067364142399	0.961113396078939	19:12525369-12551542:-	ZNF564	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 564 [Source:HGNC Symbol%3BAcc:HGNC:31106]
ENSG00000100083	28.02	25.77	28.98	26.37	26.29	29.83	0.0186996416374917	5.78927346412639	0.818103934823981	0.961113396078939	22:37608474-37633564:+	GGA1	22;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030131,cellular_component clathrin adaptor complex;GO:0030306,molecular_function ADP-ribosylation factor binding;GO:0031901,cellular_component early endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0044267,biological_process cellular protein metabolic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0061024,biological_process membrane organization;GO:1901998,biological_process toxin transport	GGA; ADP-ribosylation factor-binding protein GGA; K12404	golgi associated%2C gamma adaptin ear containing%2C ARF binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17842]
ENSG00000255837	2.06	1.44	2.14	2.26	1.96	1.82	-0.0600978136775253	0.981876996425295	0.818208205061552	0.961144927550775	12:10996494-10997875:-	TAS2R20	11;GO:0001580,biological_process detection of chemical stimulus involved in sensory perception of bitter taste;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033038,molecular_function bitter taste receptor activity;GO:0050896,biological_process response to stimulus;GO:0050909,biological_process sensory perception of taste	TAS2R; taste receptor type 2; K08474	taste 2 receptor member 20 [Source:HGNC Symbol%3BAcc:HGNC:19109]
ENSG00000100418	51.43	48.16	55.64	53.48	45.45	55.25	0.0242259449467953	4.71166352649148	0.818317528180193	0.961182388086746	22:41598027-41621096:-	DESI1	6;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding	NA	desumoylating isopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:24577]
ENSG00000082212	26.10	25.45	27.62	29.61	25.00	26.28	-0.0177711876882164	5.65510789535839	0.818557431351136	0.961362379366306	18:50878733-50954257:+	ME2	16;GO:0003824,molecular_function catalytic activity;GO:0004470,molecular_function malic enzyme activity;GO:0004471,molecular_function malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004473,molecular_function malate dehydrogenase (decarboxylating) (NADP+) activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006090,biological_process pyruvate metabolic process;GO:0006108,biological_process malate metabolic process;GO:0008152,biological_process metabolic process;GO:0008948,molecular_function oxaloacetate decarboxylase activity;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0051287,molecular_function NAD binding;GO:0055114,biological_process oxidation-reduction process;GO:1902031,biological_process regulation of NADP metabolic process	ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]; K00027	malic enzyme 2 [Source:HGNC Symbol%3BAcc:HGNC:6984]
ENSG00000104427	23.71	21.33	24.11	20.96	23.18	24.64	0.0237866648236914	4.6633812833918	0.818625662603872	0.961362379366306	8:78666046-78719765:+	ZC2HC1A	2;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger C2HC-type containing 1A [Source:HGNC Symbol%3BAcc:HGNC:24277]
ENSG00000182957	0.30	0.45	0.46	0.43	0.32	0.54	-0.106684577447746	0.86725353390496	0.818726879224308	0.961390289642545	13:23979804-24307074:+	SPATA13	19;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030175,cellular_component filopodium;GO:0030334,biological_process regulation of cell migration;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0032587,cellular_component ruffle membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046847,biological_process filopodium assembly	NA	NA
ENSG00000147316	4.31	3.54	4.19	4.44	3.78	4.23	-0.0271324283767115	3.38501497388655	0.818816942458624	0.96140509901049	8:6406591-6648504:+	MCPH1	17;GO:0000132,biological_process establishment of mitotic spindle orientation;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0010468,biological_process regulation of gene expression;GO:0021987,biological_process cerebral cortex development;GO:0042802,molecular_function identical protein binding;GO:0043549,biological_process regulation of kinase activity;GO:0046605,biological_process regulation of centrosome cycle;GO:0050727,biological_process regulation of inflammatory response;GO:0060348,biological_process bone development;GO:0060623,biological_process regulation of chromosome condensation;GO:0071539,biological_process protein localization to centrosome;GO:0071850,biological_process mitotic cell cycle arrest;GO:0097150,biological_process neuronal stem cell population maintenance	NA	microcephalin 1 [Source:HGNC Symbol%3BAcc:HGNC:6954]
ENSG00000154736	3.44	3.84	3.90	3.54	4.57	3.43	-0.0338097200774307	3.41973407968031	0.819044909305248	0.961574376964224	21:26917911-26966513:-	ADAMTS5	19;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006508,biological_process proteolysis;GO:0008201,molecular_function heparin binding;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0036066,biological_process protein O-linked fucosylation;GO:0042742,biological_process defense response to bacterium;GO:0044691,biological_process tooth eruption;GO:0046872,molecular_function metal ion binding;GO:0050840,molecular_function extracellular matrix binding	NA	ADAM metallopeptidase with thrombospondin type 1 motif 5 [Source:HGNC Symbol%3BAcc:HGNC:221]
ENSG00000100372	23.01	25.47	20.39	24.85	23.19	22.36	-0.0257677576874726	4.74153674574963	0.819116044632217	0.961574376964224	22:40769629-40819399:-	SLC25A17	32;GO:0000295,molecular_function adenine nucleotide transmembrane transporter activity;GO:0001561,biological_process fatty acid alpha-oxidation;GO:0005215,molecular_function transporter activity;GO:0005347,molecular_function ATP transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0015217,molecular_function ADP transmembrane transporter activity;GO:0015228,molecular_function coenzyme A transmembrane transporter activity;GO:0015230,molecular_function FAD transmembrane transporter activity;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0015908,biological_process fatty acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035349,biological_process coenzyme A transmembrane transport;GO:0035350,biological_process FAD transmembrane transport;GO:0043132,biological_process NAD transport;GO:0044610,molecular_function FMN transmembrane transporter activity;GO:0051087,molecular_function chaperone binding;GO:0051724,molecular_function NAD transporter activity;GO:0055085,biological_process transmembrane transport;GO:0080121,biological_process AMP transport;GO:0080122,molecular_function AMP transmembrane transporter activity;GO:1901679,biological_process nucleotide transmembrane transport	SLC25A17, PMP34; solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17; K13354	solute carrier family 25 member 17 [Source:HGNC Symbol%3BAcc:HGNC:10987]
ENSG00000073849	3.49	3.71	4.09	3.59	3.35	4.06	0.0459224739382184	2.33365828275765	0.819421709275361	0.961842238982039	3:186930484-187078553:+	ST6GAL1	19;GO:0000139,cellular_component Golgi membrane;GO:0003835,molecular_function beta-galactoside alpha-2,6-sialyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005794,cellular_component Golgi apparatus;GO:0006054,biological_process N-acetylneuraminate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006959,biological_process humoral immune response;GO:0008373,molecular_function sialyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0032580,cellular_component Golgi cisterna membrane;GO:0070062,cellular_component extracellular exosome;GO:0097503,biological_process sialylation	SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.99.1]; K00778	ST6 beta-galactoside alpha-2%2C6-sialyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:10860]
ENSG00000116985	1.70	1.35	1.10	1.30	0.88	1.75	0.0833270804948755	0.836169768109233	0.819512818463092	0.961858227645836	1:39757181-39788861:-	BMP8B	17;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0043408,biological_process regulation of MAPK cascade;GO:0048468,biological_process cell development;GO:0051216,biological_process cartilage development;GO:0060395,biological_process SMAD protein signal transduction;GO:0070700,molecular_function BMP receptor binding	BMP8; bone morphogenetic protein 8; K16622	bone morphogenetic protein 8b [Source:HGNC Symbol%3BAcc:HGNC:1075]
ENSG00000103245	10.27	12.14	13.32	12.86	10.70	13.11	-0.0293295930903784	4.30947707048882	0.819709789329977	0.961932624155271	16:729752-741329:-	NARFL	11;GO:0001666,biological_process response to hypoxia;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0010468,biological_process regulation of gene expression;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0032364,biological_process oxygen homeostasis;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0097361,cellular_component CIA complex	NA	nuclear prelamin A recognition factor like [Source:HGNC Symbol%3BAcc:HGNC:14179]
ENSG00000128563	58.21	50.07	48.73	51.11	48.28	56.64	0.0228184470579483	4.94426355405124	0.819731192968215	0.961932624155271	7:102363871-102426676:+	PRKRIP1	10;GO:0003014,biological_process renal system process;GO:0003725,molecular_function double-stranded RNA binding;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0019901,molecular_function protein kinase binding;GO:0042326,biological_process negative regulation of phosphorylation;GO:0070062,cellular_component extracellular exosome	NA	PRKR interacting protein 1 (IL11 inducible) [Source:HGNC Symbol%3BAcc:HGNC:21894]
ENSG00000169740	9.23	6.07	8.09	9.23	8.15	7.04	-0.0321601235101094	2.75028925809133	0.819972997117399	0.962062885661808	10:43643858-43648856:-	ZNF32	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 32 [Source:HGNC Symbol%3BAcc:HGNC:13095]
ENSG00000136021	14.89	15.38	16.63	15.34	15.51	15.89	0.0170011503895888	5.47890725171857	0.820040822891913	0.962062885661808	12:100267139-100341724:+	SCYL2	18;GO:0002092,biological_process positive regulation of receptor internalization;GO:0004672,molecular_function protein kinase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006468,biological_process protein phosphorylation;GO:0008333,biological_process endosome to lysosome transport;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:2000286,biological_process receptor internalization involved in canonical Wnt signaling pathway;GO:2000370,biological_process positive regulation of clathrin-mediated endocytosis	NA	SCY1 like pseudokinase 2 [Source:HGNC Symbol%3BAcc:HGNC:19286]
ENSG00000067836	11.30	13.85	12.55	12.05	12.21	12.92	0.0208834756081974	3.73283809036687	0.820131462524528	0.962062885661808	16:4796967-4802950:-	ROGDI	8;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0007420,biological_process brain development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0022008,biological_process neurogenesis;GO:0030097,biological_process hemopoiesis;GO:0042475,biological_process odontogenesis of dentin-containing tooth	NA	rogdi homolog [Source:HGNC Symbol%3BAcc:HGNC:29478]
ENSG00000163002	11.94	13.69	14.13	12.94	15.21	12.69	-0.0293069881264948	3.82805913698696	0.820187249998245	0.962062885661808	2:183117512-183161680:+	NUP35	33;GO:0003676,molecular_function nucleic acid binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005652,cellular_component nuclear lamina;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006110,biological_process regulation of glycolytic process;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006999,biological_process nuclear pore organization;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0044613,cellular_component nuclear pore central transport channel;GO:0044615,cellular_component nuclear pore nuclear basket;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP35, NUP53; nuclear pore complex protein Nup53; K14313	nucleoporin 35 [Source:HGNC Symbol%3BAcc:HGNC:29797]
ENSG00000115507	3.06	2.84	2.13	2.67	2.38	2.69	0.0584254379192183	1.69738306410503	0.820320639959371	0.962062885661808	2:63050056-63057836:+	OTX1	18;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0022037,biological_process metencephalon development;GO:0030900,biological_process forebrain development;GO:0030901,biological_process midbrain development;GO:0042472,biological_process inner ear morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048852,biological_process diencephalon morphogenesis	OTX1; homeobox protein OTX1; K09326	orthodenticle homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:8521]
ENSG00000180263	3.67	3.26	3.85	3.56	3.33	3.82	0.0282498581076008	3.99641976132197	0.820448691390779	0.962062885661808	12:95076748-95217482:-	FGD6	16;GO:0001726,cellular_component ruffle;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0008360,biological_process regulation of cell shape;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0031267,molecular_function small GTPase binding;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046847,biological_process filopodium assembly;GO:0046872,molecular_function metal ion binding	NA	FYVE%2C RhoGEF and PH domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:21740]
ENSG00000173821	33.70	32.77	34.25	34.14	32.39	34.09	0.0133223853603373	9.07175368686252	0.82072671465061	0.962062885661808	17:80260865-80398786:+	RNF213	17;GO:0000209,biological_process protein polyubiquitination;GO:0001525,biological_process angiogenesis;GO:0002040,biological_process sprouting angiogenesis;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization;GO:0051865,biological_process protein autoubiquitination;GO:2000051,biological_process negative regulation of non-canonical Wnt signaling pathway	NA	ring finger protein 213 [Source:HGNC Symbol%3BAcc:HGNC:14539]
ENSG00000123395	41.84	36.62	38.77	41.27	37.75	37.68	0.0236816970628606	4.68578895396546	0.820775934063557	0.962062885661808	12:52069245-52077494:+	ATG101	11;GO:0000045,biological_process autophagosome assembly;GO:0000407,cellular_component pre-autophagosomal structure;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0032403,molecular_function protein complex binding;GO:0042802,molecular_function identical protein binding	NA	autophagy related 101 [Source:HGNC Symbol%3BAcc:HGNC:25679]
ENSG00000167981	2.28	2.33	2.43	2.06	2.33	3.04	-0.0712341318466173	1.6909769456604	0.820787301309729	0.962062885661808	16:3432421-3443542:-	ZNF597	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 597 [Source:HGNC Symbol%3BAcc:HGNC:26573]
ENSG00000172731	12.03	9.70	10.80	12.89	11.27	9.81	-0.0378058407047999	2.65348375363812	0.820794791865624	0.962062885661808	10:70298969-70382650:-	LRRC20	1;GO:0005515,molecular_function protein binding	NA	leucine rich repeat containing 20 [Source:HGNC Symbol%3BAcc:HGNC:23421]
ENSG00000179094	3.09	3.26	3.42	3.41	3.02	3.23	0.0253521712723077	3.83845859915777	0.820850954122671	0.962062885661808	17:8140471-8156506:-	PER1	38;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0002028,biological_process regulation of sodium ion transport;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0009416,biological_process response to light stimulus;GO:0009649,biological_process entrainment of circadian clock;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0019900,molecular_function kinase binding;GO:0031490,molecular_function chromatin DNA binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0042634,biological_process regulation of hair cycle;GO:0042752,biological_process regulation of circadian rhythm;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043153,biological_process entrainment of circadian clock by photoperiod;GO:0043966,biological_process histone H3 acetylation;GO:0043967,biological_process histone H4 acetylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046329,biological_process negative regulation of JNK cascade;GO:0048511,biological_process rhythmic process;GO:0051591,biological_process response to cAMP;GO:0070888,molecular_function E-box binding;GO:0070932,biological_process histone H3 deacetylation;GO:0097167,biological_process circadian regulation of translation;GO:1900015,biological_process regulation of cytokine production involved in inflammatory response;GO:1900744,biological_process regulation of p38MAPK cascade;GO:2000323,biological_process negative regulation of glucocorticoid receptor signaling pathway	PER2; period circadian protein 2; K02633	period circadian clock 1 [Source:HGNC Symbol%3BAcc:HGNC:8845]
ENSG00000116815	38.34	35.62	41.77	41.81	39.30	37.44	-0.01781635265334	4.92016930360902	0.820929562355595	0.962062885661808	1:116514534-116571039:-	CD58	19;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030667,cellular_component secretory granule membrane;GO:0031225,cellular_component anchored component of membrane;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0043312,biological_process neutrophil degranulation;GO:0050900,biological_process leukocyte migration;GO:0070062,cellular_component extracellular exosome;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:2000484,biological_process positive regulation of interleukin-8 secretion	CD58, LFA3; CD58 antigen; K06492	CD58 molecule [Source:HGNC Symbol%3BAcc:HGNC:1688]
ENSG00000214530	8.87	8.42	9.58	9.98	6.45	9.96	0.0387385740250517	3.55817116083171	0.82093238539828	0.962062885661808	11:72754728-72794168:-	STARD10	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005902,cellular_component microvillus;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0032782,biological_process bile acid secretion;GO:0035360,biological_process positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0042995,cellular_component cell projection;GO:0046581,cellular_component intercellular canaliculus	NA	StAR related lipid transfer domain containing 10 [Source:HGNC Symbol%3BAcc:HGNC:10666]
ENSG00000139531	6.31	8.12	7.29	7.24	7.98	7.05	-0.0335501731862224	3.59637485739996	0.820982948052678	0.962062885661808	12:55997179-56006641:+	SUOX	14;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0006790,biological_process sulfur compound metabolic process;GO:0008482,molecular_function sulfite oxidase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0020037,molecular_function heme binding;GO:0030151,molecular_function molybdenum ion binding;GO:0042128,biological_process nitrate assimilation;GO:0043546,molecular_function molybdopterin cofactor binding;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070221,biological_process sulfide oxidation, using sulfide:quinone oxidoreductase	SUOX; sulfite oxidase [EC:1.8.3.1]; K00387	sulfite oxidase [Source:HGNC Symbol%3BAcc:HGNC:11460]
ENSG00000067208	6.01	5.75	5.56	5.74	6.04	5.95	-0.0223965562345481	3.94601494214015	0.82100476498957	0.962062885661808	1:92508695-92792404:-	EVI5	20;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006886,biological_process intracellular protein transport;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0008283,biological_process cell proliferation;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051301,biological_process cell division;GO:0090630,biological_process activation of GTPase activity	NA	ecotropic viral integration site 5 [Source:HGNC Symbol%3BAcc:HGNC:3501]
ENSG00000124784	10.68	11.05	10.74	10.45	10.80	10.96	0.0205455172510416	4.21847807723976	0.821197268981702	0.962133899686397	6:7389495-7418037:+	RIOK1	19;GO:0000166,molecular_function nucleotide binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016787,molecular_function hydrolase activity;GO:0030490,biological_process maturation of SSU-rRNA;GO:0030688,cellular_component preribosome, small subunit precursor;GO:0042254,biological_process ribosome biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0046872,molecular_function metal ion binding;GO:2000234,biological_process positive regulation of rRNA processing	RIOK1; RIO kinase 1 [EC:2.7.11.1]; K07178	RIO kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:18656]
ENSG00000107882	5.33	5.85	5.83	5.98	5.73	5.05	0.0320040243521849	3.19439779350721	0.821275656579967	0.962133899686397	10:102503986-102633535:+	SUFU	35;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001501,biological_process skeletal system development;GO:0001843,biological_process neural tube closure;GO:0001947,biological_process heart looping;GO:0003281,biological_process ventricular septum development;GO:0003714,molecular_function transcription corepressor activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0019901,molecular_function protein kinase binding;GO:0021513,biological_process spinal cord dorsal/ventral patterning;GO:0021775,biological_process smoothened signaling pathway involved in ventral spinal cord interneuron specification;GO:0021776,biological_process smoothened signaling pathway involved in spinal cord motor neuron cell fate specification;GO:0035904,biological_process aorta development;GO:0042992,biological_process negative regulation of transcription factor import into nucleus;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043588,biological_process skin development;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0060976,biological_process coronary vasculature development;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:1901621,biological_process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:2000059,biological_process negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	SUFU; suppressor of fused; K06229	SUFU negative regulator of hedgehog signaling [Source:HGNC Symbol%3BAcc:HGNC:16466]
ENSG00000160117	0.85	0.62	0.92	0.72	0.73	1.07	-0.0602858247450411	0.96282403170452	0.821297897452434	0.962133899686397	19:17281644-17287646:+	ANKLE1	20;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005639,cellular_component integral component of nuclear inner membrane;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006611,biological_process protein export from nucleus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006998,biological_process nuclear envelope organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031490,molecular_function chromatin DNA binding;GO:0045950,biological_process negative regulation of mitotic recombination;GO:0070197,biological_process meiotic attachment of telomere to nuclear envelope;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1905453,biological_process regulation of myeloid progenitor cell differentiation;GO:1905456,biological_process regulation of lymphoid progenitor cell differentiation;GO:2001022,biological_process positive regulation of response to DNA damage stimulus	NA	ankyrin repeat and LEM domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26812]
ENSG00000011638	61.36	57.47	54.04	65.69	54.27	56.90	-0.0204914345173563	5.10418142551173	0.821439214963256	0.962188618440611	16:21158376-21180616:+	TMEM159	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 159 [Source:HGNC Symbol%3BAcc:HGNC:30136]
ENSG00000178694	6.85	6.93	6.49	7.12	7.58	6.27	-0.0364861141728651	2.8399946919512	0.821501847561936	0.962188618440611	3:94062915-94128545:+	NSUN3	12;GO:0000049,molecular_function tRNA binding;GO:0002127,biological_process wobble base cytosine methylation;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0008168,molecular_function methyltransferase activity;GO:0016428,molecular_function tRNA (cytosine-5-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0070129,biological_process regulation of mitochondrial translation	NA	NOP2/Sun RNA methyltransferase family member 3 [Source:HGNC Symbol%3BAcc:HGNC:26208]
ENSG00000112902	19.64	18.98	15.78	17.80	20.95	16.94	-0.0222989428012605	5.88916823921509	0.821577150314351	0.962188618440611	5:9035025-9546075:-	SEMA5A	32;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002043,biological_process blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007162,biological_process negative regulation of cell adhesion;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007413,biological_process axonal fasciculation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0021536,biological_process diencephalon development;GO:0030154,biological_process cell differentiation;GO:0030215,molecular_function semaphorin receptor binding;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0035373,molecular_function chondroitin sulfate proteoglycan binding;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0038191,molecular_function neuropilin binding;GO:0043395,molecular_function heparan sulfate proteoglycan binding;GO:0045545,molecular_function syndecan binding;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048842,biological_process positive regulation of axon extension involved in axon guidance;GO:0048843,biological_process negative regulation of axon extension involved in axon guidance;GO:0050918,biological_process positive chemotaxis;GO:0050919,biological_process negative chemotaxis;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0060326,biological_process cell chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:1990256,biological_process signal clustering;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2001028,biological_process positive regulation of endothelial cell chemotaxis	SEMA5; semaphorin 5; K06841	semaphorin 5A [Source:HGNC Symbol%3BAcc:HGNC:10736]
ENSG00000134954	59.41	52.66	62.30	63.38	50.87	59.25	0.0207742212651619	6.48238232800059	0.821779727434755	0.962221936736293	11:128458760-128587558:-	ETS1	49;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001666,biological_process response to hypoxia;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0007565,biological_process female pregnancy;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009611,biological_process response to wounding;GO:0009612,biological_process response to mechanical stimulus;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010715,biological_process regulation of extracellular matrix disassembly;GO:0021854,biological_process hypothalamus development;GO:0021983,biological_process pituitary gland development;GO:0030335,biological_process positive regulation of cell migration;GO:0030578,biological_process PML body organization;GO:0032355,biological_process response to estradiol;GO:0034616,biological_process response to laminar fluid shear stress;GO:0035035,molecular_function histone acetyltransferase binding;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044849,biological_process estrous cycle;GO:0045648,biological_process positive regulation of erythrocyte differentiation;GO:0045765,biological_process regulation of angiogenesis;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048870,biological_process cell motility;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050729,biological_process positive regulation of inflammatory response;GO:0051272,biological_process positive regulation of cellular component movement;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0061614,biological_process pri-miRNA transcription from RNA polymerase II promoter;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070555,biological_process response to interleukin-1;GO:1904996,biological_process positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1990837,molecular_function sequence-specific double-stranded DNA binding	ETS1, pnt; C-ets-1; K02678	ETS proto-oncogene 1%2C transcription factor [Source:HGNC Symbol%3BAcc:HGNC:3488]
ENSG00000203791	1.90	2.27	1.97	2.16	1.96	1.74	0.0679317343939573	1.05547867943895	0.821842362345728	0.962221936736293	10:124748148-124791870:-	EEF1AKMT2	9;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0032259,biological_process methylation	NA	EEF1A lysine methyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:33787]
ENSG00000198015	47.60	43.10	47.49	52.11	42.92	42.29	0.0252332849450649	4.77504786085525	0.821856478449058	0.962221936736293	12:93467487-93516213:+	MRPL42	14;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L42 [Source:HGNC Symbol%3BAcc:HGNC:14493]
ENSG00000198612	67.04	70.32	68.55	70.74	68.82	65.60	0.0157421182902071	5.5252696881886	0.821915668671144	0.962221936736293	2:237085311-237100466:+	COPS8	15;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0008180,cellular_component COP9 signalosome;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010387,biological_process COP9 signalosome assembly;GO:0043687,biological_process post-translational protein modification;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	COP9 signalosome subunit 8 [Source:HGNC Symbol%3BAcc:HGNC:24335]
ENSG00000162032	29.18	28.36	29.44	28.96	29.13	28.59	0.0185596849786823	4.95435415193249	0.822148907626138	0.962324469519197	16:1776711-1793700:-	SPSB3	5;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0035556,biological_process intracellular signal transduction;GO:0043687,biological_process post-translational protein modification	NA	splA/ryanodine receptor domain and SOCS box containing 3 [Source:HGNC Symbol%3BAcc:HGNC:30629]
ENSG00000176095	12.60	13.15	15.24	15.11	12.67	12.81	0.0278810996116641	4.18225453130627	0.822209221087447	0.962324469519197	3:49724293-49786542:-	IP6K1	22;GO:0000166,molecular_function nucleotide binding;GO:0000827,molecular_function inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828,molecular_function inositol hexakisphosphate kinase activity;GO:0000829,molecular_function inositol heptakisphosphate kinase activity;GO:0000832,molecular_function inositol hexakisphosphate 5-kinase activity;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008440,molecular_function inositol-1,4,5-trisphosphate 3-kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0052723,molecular_function inositol hexakisphosphate 1-kinase activity;GO:0052724,molecular_function inositol hexakisphosphate 3-kinase activity;GO:0052836,molecular_function inositol 5-diphosphate pentakisphosphate 5-kinase activity;GO:0052839,molecular_function inositol diphosphate tetrakisphosphate kinase activity	IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]; K07756	inositol hexakisphosphate kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:18360]
ENSG00000188636	17.53	14.39	13.96	17.44	12.59	17.46	-0.0347967869381975	3.50546664554993	0.822235827255345	0.962324469519197	22:44492571-44498298:-	RTL6	NA	NA	retrotransposon Gag like 6 [Source:HGNC Symbol%3BAcc:HGNC:13343]
ENSG00000247315	11.68	11.07	10.17	12.20	10.41	11.17	-0.0257818764350151	3.76581634708484	0.822387515242214	0.962411259234619	20:296967-300321:+	ZCCHC3	4;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger CCHC-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:16230]
ENSG00000123064	20.63	20.95	19.92	21.51	20.69	20.44	-0.015834909768961	5.7790685534605	0.822610569248446	0.962446715614553	12:113157173-113185479:-	DDX54	22;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005102,molecular_function receptor binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030331,molecular_function estrogen receptor binding;GO:0030520,biological_process intracellular estrogen receptor signaling pathway;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	DEAD-box helicase 54 [Source:HGNC Symbol%3BAcc:HGNC:20084]
ENSG00000166439	4.19	3.46	3.98	4.23	3.50	4.34	-0.0323593076977152	3.10237159921066	0.822611193667774	0.962446715614553	11:74748867-74842413:+	RNF169	11;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031491,molecular_function nucleosome binding;GO:0035861,cellular_component site of double-strand break;GO:0046872,molecular_function metal ion binding;GO:0070530,molecular_function K63-linked polyubiquitin binding;GO:2000780,biological_process negative regulation of double-strand break repair	NA	ring finger protein 169 [Source:HGNC Symbol%3BAcc:HGNC:26961]
ENSG00000025796	51.55	47.34	53.73	50.37	47.54	54.29	0.0169639523909487	6.93111696370374	0.822725858777543	0.962446715614553	6:107867755-107958189:-	SEC63	21;GO:0001889,biological_process liver development;GO:0003723,molecular_function RNA binding;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006612,biological_process protein targeting to membrane;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006620,biological_process posttranslational protein targeting to membrane;GO:0006807,biological_process nitrogen compound metabolic process;GO:0006810,biological_process transport;GO:0008565,molecular_function protein transporter activity;GO:0010259,biological_process multicellular organism aging;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031204,biological_process posttranslational protein targeting to membrane, translocation;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0072001,biological_process renal system development	SEC63, DNAJC23; translocation protein SEC63; K09540	SEC63 homolog%2C protein translocation regulator [Source:HGNC Symbol%3BAcc:HGNC:21082]
ENSG00000113648	107.18	116.24	98.48	106.72	120.05	101.77	-0.0189048665084576	7.05472727969323	0.822727954514301	0.962446715614553	5:135333899-135399914:-	H2AFY	49;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000182,molecular_function rDNA binding;GO:0000228,cellular_component nuclear chromosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0000786,cellular_component nucleosome;GO:0000790,cellular_component nuclear chromatin;GO:0000793,cellular_component condensed chromosome;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001739,cellular_component sex chromatin;GO:0001740,cellular_component Barr body;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005721,cellular_component pericentric heterochromatin;GO:0005730,cellular_component nucleolus;GO:0006334,biological_process nucleosome assembly;GO:0006342,biological_process chromatin silencing;GO:0007549,biological_process dosage compensation;GO:0010385,molecular_function double-stranded methylated DNA binding;GO:0016569,biological_process covalent chromatin modification;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030291,molecular_function protein serine/threonine kinase inhibitor activity;GO:0031490,molecular_function chromatin DNA binding;GO:0031492,molecular_function nucleosomal DNA binding;GO:0033128,biological_process negative regulation of histone phosphorylation;GO:0034184,biological_process positive regulation of maintenance of mitotic sister chromatid cohesion;GO:0035098,cellular_component ESC/E(Z) complex;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046982,molecular_function protein heterodimerization activity;GO:0051572,biological_process negative regulation of histone H3-K4 methylation;GO:0061086,biological_process negative regulation of histone H3-K27 methylation;GO:0070062,cellular_component extracellular exosome;GO:0071169,biological_process establishment of protein localization to chromatin;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:1901837,biological_process negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;GO:1902750,biological_process negative regulation of cell cycle G2/M phase transition;GO:1902882,biological_process regulation of response to oxidative stress;GO:1904815,biological_process negative regulation of protein localization to chromosome, telomeric region	H2A; histone H2A; K11251	H2A histone family member Y [Source:HGNC Symbol%3BAcc:HGNC:4740]
ENSG00000175305	9.11	8.12	7.22	8.27	7.44	8.37	0.034651287392733	3.41092845707296	0.823217298748887	0.962808805111269	8:94879769-94896678:-	CCNE2	19;GO:0000075,biological_process cell cycle checkpoint;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000723,biological_process telomere maintenance;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006270,biological_process DNA replication initiation;GO:0007049,biological_process cell cycle;GO:0007129,biological_process synapsis;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0045859,biological_process regulation of protein kinase activity;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle;GO:0070192,biological_process chromosome organization involved in meiotic cell cycle;GO:0097135,cellular_component cyclin E2-CDK2 complex;GO:1903827,biological_process regulation of cellular protein localization	CCNE; G1/S-specific cyclin-E1; K06626	cyclin E2 [Source:HGNC Symbol%3BAcc:HGNC:1590]
ENSG00000092098	5.79	6.28	7.32	6.73	6.05	6.45	0.0230545774499326	4.40204916038627	0.823293057230136	0.962808805111269	14:24146682-24160661:+	RNF31	21;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0023035,biological_process CD40 signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035631,cellular_component CD40 receptor complex;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043130,molecular_function ubiquitin binding;GO:0046872,molecular_function metal ion binding;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0071797,cellular_component LUBAC complex;GO:0097039,biological_process protein linear polyubiquitination;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	RNF31, HOIP; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]; K11974	ring finger protein 31 [Source:HGNC Symbol%3BAcc:HGNC:16031]
ENSG00000089154	17.08	19.09	16.56	17.02	18.54	16.97	0.0156713181318813	7.13695450519347	0.823300946781239	0.962808805111269	12:120127202-120194710:-	GCN1	19;GO:0003723,molecular_function RNA binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005844,cellular_component polysome;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0016020,cellular_component membrane;GO:0019887,molecular_function protein kinase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0033554,biological_process cellular response to stress;GO:0033674,biological_process positive regulation of kinase activity;GO:0034198,biological_process cellular response to amino acid starvation;GO:0036003,biological_process positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0043022,molecular_function ribosome binding;GO:0045296,molecular_function cadherin binding;GO:0045859,biological_process regulation of protein kinase activity;GO:1990253,biological_process cellular response to leucine starvation	NA	GCN1%2C eIF2 alpha kinase activator homolog [Source:HGNC Symbol%3BAcc:HGNC:4199]
ENSG00000146535	35.36	33.98	35.16	36.82	32.52	34.89	0.0166510562420694	5.778541591286	0.823347737553864	0.962808805111269	7:2728111-2844324:-	GNA12	33;GO:0000166,molecular_function nucleotide binding;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001701,biological_process in utero embryonic development;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007188,biological_process adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007596,biological_process blood coagulation;GO:0008360,biological_process regulation of cell shape;GO:0010762,biological_process regulation of fibroblast migration;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0031526,cellular_component brush border membrane;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031752,molecular_function D5 dopamine receptor binding;GO:0032006,biological_process regulation of TOR signaling;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035556,biological_process intracellular signal transduction;GO:0042493,biological_process response to drug;GO:0042733,biological_process embryonic digit morphogenesis;GO:0046872,molecular_function metal ion binding	GNA12; guanine nucleotide-binding protein subunit alpha-12; K04346	G protein subunit alpha 12 [Source:HGNC Symbol%3BAcc:HGNC:4380]
ENSG00000162695	8.87	8.59	8.73	9.08	8.60	8.22	0.0306248978484885	3.33763364012803	0.823626984831239	0.963044627233437	1:100896075-100981753:+	SLC30A7	20;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006829,biological_process zinc II ion transport;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0010043,biological_process response to zinc ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0032119,biological_process sequestering of zinc ion;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055085,biological_process transmembrane transport;GO:0061088,biological_process regulation of sequestering of zinc ion;GO:0070062,cellular_component extracellular exosome;GO:0071577,biological_process zinc II ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	solute carrier family 30 member 7 [Source:HGNC Symbol%3BAcc:HGNC:19306]
ENSG00000213865	20.93	24.38	21.20	24.80	22.32	21.27	-0.0363737103229598	3.46578612703001	0.823832750889764	0.963194493434552	8:66667614-66685564:+	C8orf44	1;GO:0005654,cellular_component nucleoplasm	NA	chromosome 8 open reading frame 44 [Source:HGNC Symbol%3BAcc:HGNC:25646]
ENSG00000095321	25.73	24.53	24.90	24.89	27.32	24.47	-0.0151046814751478	5.79954661818616	0.824059792027543	0.963367142874135	9:129094809-129111189:-	CRAT	15;GO:0004092,molecular_function carnitine O-acetyltransferase activity;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019254,biological_process carnitine metabolic process, CoA-linked;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase	E2.3.1.7; carnitine O-acetyltransferase [EC:2.3.1.7]; K00624	carnitine O-acetyltransferase [Source:HGNC Symbol%3BAcc:HGNC:2342]
ENSG00000143373	10.87	12.46	12.84	12.63	12.19	12.08	-0.0191902735046741	5.54402498520766	0.824135639263711	0.963367142874135	1:151281617-151292180:+	ZNF687	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 687 [Source:HGNC Symbol%3BAcc:HGNC:29277]
ENSG00000119242	31.02	31.60	30.03	30.40	30.64	31.17	0.0164845562849677	4.94537658317963	0.824256789326773	0.963418034455106	12:123918659-123972831:-	CCDC92	7;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	coiled-coil domain containing 92 [Source:HGNC Symbol%3BAcc:HGNC:29563]
ENSG00000132470	3.49	3.05	3.67	3.61	3.02	3.88	-0.0244879154087178	4.31746272456928	0.824759662480386	0.963904426250684	17:75721327-75757818:+	ITGB4	31;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0006914,biological_process autophagy;GO:0007154,biological_process cell communication;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009611,biological_process response to wounding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030056,cellular_component hemidesmosome;GO:0030198,biological_process extracellular matrix organization;GO:0031252,cellular_component cell leading edge;GO:0031581,biological_process hemidesmosome assembly;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0035878,biological_process nail development;GO:0038132,molecular_function neuregulin binding;GO:0043235,cellular_component receptor complex;GO:0043588,biological_process skin development;GO:0048333,biological_process mesodermal cell differentiation;GO:0048565,biological_process digestive tract development;GO:0048870,biological_process cell motility;GO:0070062,cellular_component extracellular exosome;GO:0072001,biological_process renal system development;GO:0097186,biological_process amelogenesis	ITGB4, CD104; integrin beta 4; K06525	integrin subunit beta 4 [Source:HGNC Symbol%3BAcc:HGNC:6158]
ENSG00000150712	17.68	17.92	17.52	16.97	18.25	18.93	-0.0174793030740836	5.3535164489307	0.8248282297297	0.963904426250684	5:32226993-32313009:-	MTMR12	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0019208,molecular_function phosphatase regulator activity;GO:0050790,biological_process regulation of catalytic activity;GO:1901998,biological_process toxin transport	NA	myotubularin related protein 12 [Source:HGNC Symbol%3BAcc:HGNC:18191]
ENSG00000183340	21.57	22.68	21.12	22.10	20.22	22.68	0.0159341221047372	5.10023165872567	0.824979025167394	0.96391385971983	11:96389988-96507574:+	JRKL	4;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0007417,biological_process central nervous system development	NA	JRK like [Source:HGNC Symbol%3BAcc:HGNC:6200]
ENSG00000157540	15.11	14.35	15.40	15.35	13.66	16.85	-0.0193287463465113	5.17233228564451	0.825038582386965	0.96391385971983	21:37365789-37517450:+	DYRK1A	30;GO:0000166,molecular_function nucleotide binding;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007399,biological_process nervous system development;GO:0007623,biological_process circadian rhythm;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042802,molecular_function identical protein binding;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043621,molecular_function protein self-association;GO:0046777,biological_process protein autophosphorylation;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0048156,molecular_function tau protein binding;GO:0090312,biological_process positive regulation of protein deacetylation	NA	dual specificity tyrosine phosphorylation regulated kinase 1A [Source:HGNC Symbol%3BAcc:HGNC:3091]
ENSG00000152465	34.05	32.46	30.55	30.69	33.80	32.25	0.0166854404679218	5.63880306369698	0.82506926283116	0.96391385971983	10:15102583-15168693:-	NMT2	14;GO:0004379,molecular_function glycylpeptide N-tetradecanoyltransferase activity;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006499,biological_process N-terminal protein myristoylation;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018008,biological_process N-terminal peptidyl-glycine N-myristoylation;GO:0019898,cellular_component extrinsic component of membrane;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0043657,cellular_component host cell;GO:0075733,biological_process intracellular transport of virus	NA	N-myristoyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:7858]
ENSG00000130005	28.55	26.60	25.16	25.43	28.09	26.34	0.0210929560340732	4.6665201849815	0.825173989400701	0.963934676030156	19:1397025-1401570:-	GAMT	16;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006600,biological_process creatine metabolic process;GO:0006601,biological_process creatine biosynthetic process;GO:0006936,biological_process muscle contraction;GO:0007283,biological_process spermatogenesis;GO:0008168,molecular_function methyltransferase activity;GO:0009887,biological_process organ morphogenesis;GO:0016740,molecular_function transferase activity;GO:0030731,molecular_function guanidinoacetate N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0040014,biological_process regulation of multicellular organism growth;GO:0046498,biological_process S-adenosylhomocysteine metabolic process;GO:0046500,biological_process S-adenosylmethionine metabolic process;GO:0070062,cellular_component extracellular exosome	GAMT; guanidinoacetate N-methyltransferase [EC:2.1.1.2]; K00542	guanidinoacetate N-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:4136]
ENSG00000177105	21.82	25.68	23.76	22.34	25.28	25.40	-0.0319132404703288	3.79806670300215	0.825354765073589	0.963934676030156	11:3826977-3840983:-	RHOG	25;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016601,biological_process Rac protein signal transduction;GO:0030036,biological_process actin cytoskeleton organization;GO:0030168,biological_process platelet activation;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0060326,biological_process cell chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0090630,biological_process activation of GTPase activity;GO:1900027,biological_process regulation of ruffle assembly	RHOG; Ras homolog gene family, member G; K07863	ras homolog family member G [Source:HGNC Symbol%3BAcc:HGNC:672]
ENSG00000066422	11.10	10.30	10.89	10.30	10.94	10.96	0.018523890961009	5.13820465611405	0.825393364461551	0.963934676030156	3:101648888-101677495:-	ZBTB11	9;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 11 [Source:HGNC Symbol%3BAcc:HGNC:16740]
ENSG00000151687	0.65	0.57	1.09	0.73	0.75	0.96	-0.0503600808193998	1.8553154102814	0.825401049974306	0.963934676030156	2:189674289-189761193:+	ANKAR	4;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	ankyrin and armadillo repeat containing [Source:HGNC Symbol%3BAcc:HGNC:26350]
ENSG00000106868	18.18	17.81	17.46	18.01	17.28	18.01	0.0156256736632633	5.44370905563086	0.82547535698063	0.963934676030156	9:112040784-112175408:-	SUSD1	3;GO:0005509,molecular_function calcium ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	sushi domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25413]
ENSG00000157796	17.89	17.45	19.03	17.27	18.40	19.76	-0.015625205052544	6.20957748339079	0.825555859955691	0.96393800109397	4:39182403-39285810:+	WDR19	28;GO:0000902,biological_process cell morphogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001750,cellular_component photoreceptor outer segment;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007224,biological_process smoothened signaling pathway;GO:0008406,biological_process gonad development;GO:0030030,biological_process cell projection organization;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030991,cellular_component intraciliary transport particle A;GO:0031076,biological_process embryonic camera-type eye development;GO:0031514,cellular_component motile cilium;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0035721,biological_process intraciliary retrograde transport;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042471,biological_process ear morphogenesis;GO:0042995,cellular_component cell projection;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0050877,biological_process neurological system process;GO:0055123,biological_process digestive system development;GO:0060271,biological_process cilium morphogenesis;GO:0060830,biological_process ciliary receptor clustering involved in smoothened signaling pathway;GO:0060831,biological_process smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0061055,biological_process myotome development;GO:0097542,cellular_component ciliary tip;GO:0097730,cellular_component non-motile cilium	NA	WD repeat domain 19 [Source:HGNC Symbol%3BAcc:HGNC:18340]
ENSG00000117625	21.01	19.51	22.56	20.29	21.68	20.95	0.019666538382291	5.31548508555721	0.825671277738693	0.963951648280934	1:211258376-211316385:+	RCOR3	12;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0017053,cellular_component transcriptional repressor complex;GO:0044212,molecular_function transcription regulatory region DNA binding	NA	REST corepressor 3 [Source:HGNC Symbol%3BAcc:HGNC:25594]
ENSG00000141985	66.98	65.01	62.33	69.92	62.65	61.15	0.0164374594021677	6.16167422649775	0.8257228612077	0.963951648280934	19:4360369-4400547:-	SH3GL1	18;GO:0002102,cellular_component podosome;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0007417,biological_process central nervous system development;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016191,biological_process synaptic vesicle uncoating;GO:0019902,molecular_function phosphatase binding;GO:0030054,cellular_component cell junction;GO:0031901,cellular_component early endosome membrane;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0045202,cellular_component synapse;GO:0045296,molecular_function cadherin binding;GO:0051020,molecular_function GTPase binding	SH3GL; endophilin-A; K11247	SH3 domain containing GRB2 like 1%2C endophilin A2 [Source:HGNC Symbol%3BAcc:HGNC:10830]
ENSG00000072062	40.14	50.05	45.43	47.91	45.37	41.45	0.0178695964203977	5.9487704642818	0.826000343732123	0.964184903775329	19:14091687-14118084:-	PRKACA	79;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001669,cellular_component acrosomal vesicle;GO:0001707,biological_process mesoderm formation;GO:0001843,biological_process neural tube closure;GO:0002027,biological_process regulation of heart rate;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003091,biological_process renal water homeostasis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004691,molecular_function cAMP-dependent protein kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0005952,cellular_component cAMP-dependent protein kinase complex;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0007596,biological_process blood coagulation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030145,molecular_function manganese ion binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031514,cellular_component motile cilium;GO:0031594,cellular_component neuromuscular junction;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034199,biological_process activation of protein kinase A activity;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0034380,biological_process high-density lipoprotein particle assembly;GO:0034605,biological_process cellular response to heat;GO:0034704,cellular_component calcium channel complex;GO:0035584,biological_process calcium-mediated signaling using intracellular calcium source;GO:0036126,cellular_component sperm flagellum;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043393,biological_process regulation of protein binding;GO:0044853,cellular_component plasma membrane raft;GO:0045171,cellular_component intercellular bridge;GO:0045667,biological_process regulation of osteoblast differentiation;GO:0046777,biological_process protein autophosphorylation;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0048240,biological_process sperm capacitation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050804,biological_process modulation of synaptic transmission;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0055117,biological_process regulation of cardiac muscle contraction;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0061136,biological_process regulation of proteasomal protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0070613,biological_process regulation of protein processing;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071374,biological_process cellular response to parathyroid hormone stimulus;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0071872,biological_process cellular response to epinephrine stimulus;GO:0086064,biological_process cell communication by electrical coupling involved in cardiac conduction;GO:0097546,cellular_component ciliary base;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1901621,biological_process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:1903779,biological_process regulation of cardiac conduction;GO:2000810,biological_process regulation of bicellular tight junction assembly	PKA; protein kinase A [EC:2.7.11.11]; K04345	protein kinase cAMP-activated catalytic subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:9380]
ENSG00000163739	10.78	9.23	6.88	9.80	6.38	9.64	0.0670836883633625	1.57345630413871	0.82614186981278	0.964248390279282	4:73869392-73871242:+	CXCL1	27;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007399,biological_process nervous system development;GO:0008009,molecular_function chemokine activity;GO:0008047,molecular_function enzyme activator activity;GO:0008083,molecular_function growth factor activity;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0030036,biological_process actin cytoskeleton organization;GO:0032496,biological_process response to lipopolysaccharide;GO:0035556,biological_process intracellular signal transduction;GO:0035580,cellular_component specific granule lumen;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043312,biological_process neutrophil degranulation;GO:0045236,molecular_function CXCR chemokine receptor binding;GO:0060326,biological_process cell chemotaxis;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:1904724,cellular_component tertiary granule lumen	CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3; K05505	C-X-C motif chemokine ligand 1 [Source:HGNC Symbol%3BAcc:HGNC:4602]
ENSG00000164221	12.91	10.96	11.87	10.90	12.04	12.58	0.0261374967644428	4.2522582706163	0.826210092565089	0.964248390279282	5:115267187-115296831:-	CCDC112	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 112 [Source:HGNC Symbol%3BAcc:HGNC:28599]
ENSG00000163132	3.19	2.94	3.89	3.79	2.75	4.02	-0.059195896573337	1.71856551527123	0.826438490455456	0.964424272071409	4:4859665-4863936:+	MSX1	62;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000902,biological_process cell morphogenesis;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0002039,molecular_function p53 binding;GO:0003007,biological_process heart morphogenesis;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0007517,biological_process muscle organ development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010463,biological_process mesenchymal cell proliferation;GO:0021983,biological_process pituitary gland development;GO:0023019,biological_process signal transduction involved in regulation of gene expression;GO:0030308,biological_process negative regulation of cell growth;GO:0030326,biological_process embryonic limb morphogenesis;GO:0030509,biological_process BMP signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030900,biological_process forebrain development;GO:0030901,biological_process midbrain development;GO:0034504,biological_process protein localization to nucleus;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0035326,molecular_function enhancer binding;GO:0035880,biological_process embryonic nail plate morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042476,biological_process odontogenesis;GO:0042481,biological_process regulation of odontogenesis;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043392,biological_process negative regulation of DNA binding;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048863,biological_process stem cell differentiation;GO:0050821,biological_process protein stabilization;GO:0051154,biological_process negative regulation of striated muscle cell differentiation;GO:0051216,biological_process cartilage development;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis;GO:0060349,biological_process bone morphogenesis;GO:0060536,biological_process cartilage morphogenesis;GO:0061180,biological_process mammary gland epithelium development;GO:0061312,biological_process BMP signaling pathway involved in heart development;GO:0071316,biological_process cellular response to nicotine;GO:0090427,biological_process activation of meiosis;GO:1902255,biological_process positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding;GO:2001055,biological_process positive regulation of mesenchymal cell apoptotic process	MSX; homeobox protein MSX; K09341	msh homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:7391]
ENSG00000154277	502.85	478.22	475.00	499.72	482.02	499.51	-0.0128367253401883	8.49078488962576	0.826717388042405	0.964638230640251	4:41256412-41268455:+	UCHL1	42;GO:0002931,biological_process response to ischemia;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007409,biological_process axonogenesis;GO:0007412,biological_process axon target recognition;GO:0007628,biological_process adult walking behavior;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008242,molecular_function omega peptidase activity;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016874,molecular_function ligase activity;GO:0019233,biological_process sensory perception of pain;GO:0019896,biological_process axonal transport of mitochondrion;GO:0030424,cellular_component axon;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031694,molecular_function alpha-2A adrenergic receptor binding;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042755,biological_process eating behavior;GO:0043025,cellular_component neuronal cell body;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043209,cellular_component myelin sheath;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0044306,cellular_component neuron projection terminus;GO:0048747,biological_process muscle fiber development;GO:0050905,biological_process neuromuscular process;GO:0070062,cellular_component extracellular exosome;GO:1904115,cellular_component axon cytoplasm	UCHL1; ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]; K05611	ubiquitin C-terminal hydrolase L1 [Source:HGNC Symbol%3BAcc:HGNC:12513]
ENSG00000180011	11.24	14.96	11.91	11.78	12.67	14.67	-0.0393862324084902	3.87371310082288	0.826783635202097	0.964638230640251	18:75195107-75209348:-	ZADH2	11;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0006693,biological_process prostaglandin metabolic process;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0036132,molecular_function 13-prostaglandin reductase activity;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0047522,molecular_function 15-oxoprostaglandin 13-oxidase activity;GO:0055114,biological_process oxidation-reduction process	NA	zinc binding alcohol dehydrogenase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28697]
ENSG00000128833	3.71	4.16	3.58	3.37	4.39	3.96	-0.0271374616748384	4.34688824863077	0.826854972529789	0.964638230640251	15:52192321-52295798:-	MYO5C	7;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0016459,cellular_component myosin complex;GO:0070062,cellular_component extracellular exosome	MYO5; myosin V; K10357	myosin VC [Source:HGNC Symbol%3BAcc:HGNC:7604]
ENSG00000184371	140.80	121.70	143.53	136.27	123.19	145.13	0.0178245607480998	7.86451081812117	0.827011153980083	0.964729767348442	1:109910241-109930992:+	CSF1	52;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002158,biological_process osteoclast proliferation;GO:0002376,biological_process immune system process;GO:0003006,biological_process developmental process involved in reproduction;GO:0005125,molecular_function cytokine activity;GO:0005157,molecular_function macrophage colony-stimulating factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008083,molecular_function growth factor activity;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010628,biological_process positive regulation of gene expression;GO:0010743,biological_process regulation of macrophage derived foam cell differentiation;GO:0010744,biological_process positive regulation of macrophage derived foam cell differentiation;GO:0010759,biological_process positive regulation of macrophage chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030225,biological_process macrophage differentiation;GO:0030278,biological_process regulation of ossification;GO:0030316,biological_process osteoclast differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032946,biological_process positive regulation of mononuclear cell proliferation;GO:0038145,biological_process macrophage colony-stimulating factor signaling pathway;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042117,biological_process monocyte activation;GO:0042488,biological_process positive regulation of odontogenesis of dentin-containing tooth;GO:0042803,molecular_function protein homodimerization activity;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0045087,biological_process innate immune response;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045657,biological_process positive regulation of monocyte differentiation;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0060444,biological_process branching involved in mammary gland duct morphogenesis;GO:0060611,biological_process mammary gland fat development;GO:0060763,biological_process mammary duct terminal end bud growth;GO:0070062,cellular_component extracellular exosome;GO:1902228,biological_process positive regulation of macrophage colony-stimulating factor signaling pathway;GO:1904141,biological_process positive regulation of microglial cell migration;GO:1990682,cellular_component CSF1-CSF1R complex	CSF1, MCSF; macrophage colony-stimulating factor 1; K05453	colony stimulating factor 1 [Source:HGNC Symbol%3BAcc:HGNC:2432]
ENSG00000176531	1.61	1.43	1.90	1.36	1.49	1.97	0.0573046256101365	1.72957455359887	0.827218495206339	0.964816705859636	19:43474953-43504935:-	PHLDB3	1;GO:0019899,molecular_function enzyme binding	NA	pleckstrin homology like domain family B member 3 [Source:HGNC Symbol%3BAcc:HGNC:30499]
ENSG00000080603	0.20	0.30	0.26	0.18	0.35	0.18	0.0813652393038098	1.32838041930271	0.82724113433208	0.964816705859636	16:30698208-30741409:+	SRCAP	20;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004386,molecular_function helicase activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0043234,cellular_component protein complex;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	Snf2 related CREBBP activator protein [Source:HGNC Symbol%3BAcc:HGNC:16974]
ENSG00000186787	3.34	3.57	4.85	3.45	3.58	4.37	0.0577779160044166	1.70794851892925	0.82733607416413	0.964836780214143	X:57118550-57121546:-	SPIN2B	7;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007276,biological_process gamete generation;GO:0051726,biological_process regulation of cell cycle	NA	spindlin family member 2B [Source:HGNC Symbol%3BAcc:HGNC:33147]
ENSG00000121741	12.79	11.15	12.29	11.94	11.95	13.11	-0.0151122804980441	5.66328671270104	0.82746020656216	0.964872300790161	13:19958669-20091829:+	ZMYM2	19;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0007275,biological_process multicellular organism development;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0016605,cellular_component PML body;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0022604,biological_process regulation of cell morphogenesis;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger MYM-type containing 2 [Source:HGNC Symbol%3BAcc:HGNC:12989]
ENSG00000115290	26.14	24.81	25.81	25.70	24.00	26.85	0.0168987979358707	5.39351684746788	0.827521994216713	0.964872300790161	2:164492811-164621848:-	GRB14	15;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0050900,biological_process leukocyte migration	NA	growth factor receptor bound protein 14 [Source:HGNC Symbol%3BAcc:HGNC:4565]
ENSG00000144935	14.31	14.34	16.34	15.01	13.84	15.93	0.0193911850797309	5.1617430348102	0.827682229204827	0.964968489820561	3:142724073-142807888:+	TRPC1	22;GO:0005216,molecular_function ion channel activity;GO:0005261,molecular_function cation channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006828,biological_process manganese ion transport;GO:0015279,molecular_function store-operated calcium channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042438,biological_process melanin biosynthetic process;GO:0043235,cellular_component receptor complex;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0051480,biological_process regulation of cytosolic calcium ion concentration;GO:0051592,biological_process response to calcium ion;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0070679,molecular_function inositol 1,4,5 trisphosphate binding;GO:1903779,biological_process regulation of cardiac conduction	TRPC1; transient receptor potential cation channel subfamily C member 1; K04964	transient receptor potential cation channel subfamily C member 1 [Source:HGNC Symbol%3BAcc:HGNC:12333]
ENSG00000174672	0.92	0.59	0.76	0.37	1.22	0.84	-0.070307429727883	1.14743116430174	0.827996088846467	0.965141404030763	11:1389898-1462689:+	BRSK2	38;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006887,biological_process exocytosis;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030010,biological_process establishment of cell polarity;GO:0030182,biological_process neuron differentiation;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0036503,biological_process ERAD pathway;GO:0043462,biological_process regulation of ATPase activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048812,biological_process neuron projection morphogenesis;GO:0050321,molecular_function tau-protein kinase activity;GO:0051117,molecular_function ATPase binding;GO:0051301,biological_process cell division;GO:0060590,molecular_function ATPase regulator activity;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1904152,biological_process regulation of retrograde protein transport, ER to cytosol	NA	BR serine/threonine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:11405]
ENSG00000100625	2.53	2.16	2.01	2.01	2.36	2.19	0.0468354661684268	2.41795047566408	0.828097178453851	0.965141404030763	14:60709527-60724348:-	SIX4	46;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008582,biological_process regulation of synaptic growth at neuromuscular junction;GO:0008584,biological_process male gonad development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010468,biological_process regulation of gene expression;GO:0030238,biological_process male sex determination;GO:0030910,biological_process olfactory placode formation;GO:0032880,biological_process regulation of protein localization;GO:0034504,biological_process protein localization to nucleus;GO:0042472,biological_process inner ear morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043586,biological_process tongue development;GO:0045214,biological_process sarcomere organization;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046661,biological_process male sex differentiation;GO:0048538,biological_process thymus development;GO:0048699,biological_process generation of neurons;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048856,biological_process anatomical structure development;GO:0050678,biological_process regulation of epithelial cell proliferation;GO:0051451,biological_process myoblast migration;GO:0060037,biological_process pharyngeal system development;GO:0061055,biological_process myotome development;GO:0061197,biological_process fungiform papilla morphogenesis;GO:0061551,biological_process trigeminal ganglion development;GO:0072075,biological_process metanephric mesenchyme development;GO:0072095,biological_process regulation of branch elongation involved in ureteric bud branching;GO:0072107,biological_process positive regulation of ureteric bud formation;GO:0090190,biological_process positive regulation of branching involved in ureteric bud morphogenesis;GO:0098528,biological_process skeletal muscle fiber differentiation;GO:1902725,biological_process negative regulation of satellite cell differentiation	SIX4; homeobox protein SIX4; K15615	SIX homeobox 4 [Source:HGNC Symbol%3BAcc:HGNC:10890]
ENSG00000132676	70.05	64.70	67.33	70.21	61.40	69.95	0.0163550057756011	6.50899570675347	0.828182074773349	0.965141404030763	1:155687959-155739010:+	DAP3	17;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006915,biological_process apoptotic process;GO:0015935,cellular_component small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination;GO:0097190,biological_process apoptotic signaling pathway	NA	death associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:2673]
ENSG00000257365	1.19	1.97	1.24	1.14	1.56	1.45	0.0551228735629965	0.993273339656241	0.828200661811546	0.965141404030763	14:64986719-65062652:+	FNTB	27;GO:0003824,molecular_function catalytic activity;GO:0004311,molecular_function farnesyltranstransferase activity;GO:0004659,molecular_function prenyltransferase activity;GO:0004660,molecular_function protein farnesyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005875,cellular_component microtubule associated complex;GO:0005965,cellular_component protein farnesyltransferase complex;GO:0008144,molecular_function drug binding;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010035,biological_process response to inorganic substance;GO:0014070,biological_process response to organic cyclic compound;GO:0016740,molecular_function transferase activity;GO:0018343,biological_process protein farnesylation;GO:0019840,molecular_function isoprenoid binding;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0034097,biological_process response to cytokine;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0042277,molecular_function peptide binding;GO:0043234,cellular_component protein complex;GO:0045787,biological_process positive regulation of cell cycle;GO:0046872,molecular_function metal ion binding;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051770,biological_process positive regulation of nitric-oxide synthase biosynthetic process	FNTB; protein farnesyltransferase subunit beta [EC:2.5.1.58]; K05954	farnesyltransferase%2C CAAX box%2C beta [Source:HGNC Symbol%3BAcc:HGNC:3785]
ENSG00000133119	8.32	9.52	7.67	8.95	8.86	8.41	-0.0384497430900165	3.26895175457917	0.828390619195911	0.965141404030763	13:33818048-33966558:+	RFC3	24;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005663,cellular_component DNA replication factor C complex;GO:0006260,biological_process DNA replication;GO:0006271,biological_process DNA strand elongation involved in DNA replication;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0016887,molecular_function ATPase activity;GO:0019985,biological_process translesion synthesis;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0046683,biological_process response to organophosphorus;GO:0070987,biological_process error-free translesion synthesis;GO:1900264,biological_process positive regulation of DNA-directed DNA polymerase activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RFC3_5; replication factor C subunit 3/5; K10756	replication factor C subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:9971]
ENSG00000060688	26.82	29.76	25.34	28.30	27.95	27.25	-0.0216008755071982	4.99942094253634	0.82856028291214	0.965141404030763	1:31259567-31296782:-	SNRNP40	18;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005682,cellular_component U5 snRNP;GO:0005732,cellular_component small nucleolar ribonucleoprotein complex;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016607,cellular_component nuclear speck;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	SNRNP40, PRP8BP; Prp8 binding protein; K12857	small nuclear ribonucleoprotein U5 subunit 40 [Source:HGNC Symbol%3BAcc:HGNC:30857]
ENSG00000139505	8.87	9.08	9.24	9.00	9.08	8.91	0.0223668184362409	4.08571748803392	0.828625316911407	0.965141404030763	13:25246200-25288009:-	MTMR6	18;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0015269,molecular_function calcium-activated potassium channel activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0052866,molecular_function phosphatidylinositol phosphate phosphatase activity;GO:0071805,biological_process potassium ion transmembrane transport	NA	myotubularin related protein 6 [Source:HGNC Symbol%3BAcc:HGNC:7453]
ENSG00000167384	4.11	5.65	4.25	4.13	4.45	5.13	0.0273136812361307	3.42320186163109	0.828692168228668	0.965141404030763	19:44474427-44500524:-	ZNF180	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 180 [Source:HGNC Symbol%3BAcc:HGNC:12970]
ENSG00000090554	3.67	3.11	2.40	3.30	1.87	3.65	0.0657063207148858	1.83605669650218	0.82880567152966	0.965141404030763	19:49474206-49486231:+	FLT3LG	26;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030098,biological_process lymphocyte differentiation;GO:0030885,biological_process regulation of myeloid dendritic cell activation;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031233,cellular_component intrinsic component of external side of plasma membrane;GO:0032825,biological_process positive regulation of natural killer cell differentiation;GO:0035162,biological_process embryonic hemopoiesis;GO:0042803,molecular_function protein homodimerization activity;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045787,biological_process positive regulation of cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0071864,biological_process positive regulation of cell proliferation in bone marrow;GO:0071866,biological_process negative regulation of apoptotic process in bone marrow;GO:0090290,biological_process positive regulation of osteoclast proliferation;GO:1901741,biological_process positive regulation of myoblast fusion	FLT3LG; fms-related tyrosine kinase 3 ligand; K05454	fms related tyrosine kinase 3 ligand [Source:HGNC Symbol%3BAcc:HGNC:3766]
ENSG00000166889	48.34	44.64	52.32	48.65	46.98	49.37	0.0163960359611625	6.80813946273383	0.828823518374171	0.965141404030763	11:59636715-59668980:-	PATL1	14;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008266,molecular_function poly(U) RNA binding;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0030014,cellular_component CCR4-NOT complex;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0034046,molecular_function poly(G) binding;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	PATL1, PAT1; DNA topoisomerase 2-associated protein PAT1; K12617	PAT1 homolog 1%2C processing body mRNA decay factor [Source:HGNC Symbol%3BAcc:HGNC:26721]
ENSG00000159214	11.01	10.73	12.29	11.81	10.41	11.48	0.0288092046934367	3.62571555392512	0.828881262031088	0.965141404030763	1:43991358-43996528:+	CCDC24	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 24 [Source:HGNC Symbol%3BAcc:HGNC:28688]
ENSG00000072682	71.43	62.73	69.76	73.00	62.88	72.19	-0.01596616158082	6.92165336639031	0.828912124480573	0.965141404030763	5:132191837-132295315:-	P4HA2	16;GO:0004656,molecular_function procollagen-proline 4-dioxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005829,cellular_component cytosol;GO:0009055,molecular_function electron carrier activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0019511,biological_process peptidyl-proline hydroxylation;GO:0031418,molecular_function L-ascorbic acid binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	P4HA; prolyl 4-hydroxylase [EC:1.14.11.2]; K00472	prolyl 4-hydroxylase subunit alpha 2 [Source:HGNC Symbol%3BAcc:HGNC:8547]
ENSG00000156983	9.51	7.75	8.16	8.88	8.60	8.57	-0.0166921827068809	4.98347638325496	0.828991032758938	0.965141404030763	3:9731728-9748018:+	BRPF1	18;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0043966,biological_process histone H3 acetylation;GO:0043972,biological_process histone H3-K23 acetylation;GO:0043994,molecular_function histone acetyltransferase activity (H3-K23 specific);GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070776,cellular_component MOZ/MORF histone acetyltransferase complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	bromodomain and PHD finger containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14255]
ENSG00000164291	4.22	4.83	4.96	4.43	5.68	4.37	-0.0379127545430442	3.05597513051282	0.829076865329456	0.965141404030763	5:95555073-95605064:+	ARSK	10;GO:0003824,molecular_function catalytic activity;GO:0004065,molecular_function arylsulfatase activity;GO:0005576,cellular_component extracellular region;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0008484,molecular_function sulfuric ester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	arylsulfatase family member K [Source:HGNC Symbol%3BAcc:HGNC:25239]
ENSG00000134202	69.09	74.21	64.18	74.46	68.82	68.11	-0.0185764035307598	5.68288561485004	0.829159051648828	0.965141404030763	1:109733931-109741038:-	GSTM3	20;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0008065,biological_process establishment of blood-nerve barrier;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0018916,biological_process nitrobenzene metabolic process;GO:0019899,molecular_function enzyme binding;GO:0035686,cellular_component sperm fibrous sheath;GO:0042178,biological_process xenobiotic catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043295,molecular_function glutathione binding;GO:0043627,biological_process response to estrogen;GO:0070062,cellular_component extracellular exosome;GO:0070458,biological_process cellular detoxification of nitrogen compound;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase mu 3 [Source:HGNC Symbol%3BAcc:HGNC:4635]
ENSG00000112874	10.45	10.34	9.51	11.18	9.25	10.65	-0.0279396477010874	3.84181727742069	0.829162107452865	0.965141404030763	5:103548854-103562793:-	NUDT12	12;GO:0000210,molecular_function NAD+ diphosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006742,biological_process NADP catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019677,biological_process NAD catabolic process;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0035529,molecular_function NADH pyrophosphatase activity;GO:0046872,molecular_function metal ion binding	E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22]; K03426	nudix hydrolase 12 [Source:HGNC Symbol%3BAcc:HGNC:18826]
ENSG00000129534	8.46	9.65	8.60	8.25	10.25	8.79	-0.0234126748802617	4.9608168840934	0.829511182288319	0.965141404030763	14:45203189-45253540:-	MIS18BP1	10;GO:0000775,cellular_component chromosome, centromeric region;GO:0000778,cellular_component condensed nuclear chromosome kinetochore;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0007049,biological_process cell cycle;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0051301,biological_process cell division	NA	MIS18 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20190]
ENSG00000215305	12.40	11.54	10.99	12.37	11.03	11.37	0.0198298975987919	4.87876168227971	0.829536551791946	0.965141404030763	20:2840702-2866732:+	VPS16	27;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006914,biological_process autophagy;GO:0007033,biological_process vacuole organization;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030424,cellular_component axon;GO:0030897,cellular_component HOPS complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0032889,biological_process regulation of vacuole fusion, non-autophagic;GO:0035542,biological_process regulation of SNARE complex assembly;GO:0043025,cellular_component neuronal cell body;GO:0051015,molecular_function actin filament binding;GO:0055037,cellular_component recycling endosome;GO:0097352,biological_process autophagosome maturation	NA	VPS16%2C CORVET/HOPS core subunit [Source:HGNC Symbol%3BAcc:HGNC:14584]
ENSG00000076662	5.47	6.75	5.66	5.54	6.56	5.45	0.0293373411405735	3.3989585234342	0.829623969652211	0.965141404030763	19:10333775-10339823:-	ICAM3	14;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0005102,molecular_function receptor binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006909,biological_process phagocytosis;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0050776,biological_process regulation of immune response;GO:0070062,cellular_component extracellular exosome	ICAM3, CD50; intercellular adhesion molecule 3; K06486	intercellular adhesion molecule 3 [Source:HGNC Symbol%3BAcc:HGNC:5346]
ENSG00000125484	10.91	11.97	12.18	11.66	11.93	12.18	-0.019912567747352	4.87116355029334	0.829661267620517	0.965141404030763	9:132670034-132694955:+	GTF3C4	17;GO:0000127,cellular_component transcription factor TFIIIC complex;GO:0003677,molecular_function DNA binding;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0006384,biological_process transcription initiation from RNA polymerase III promoter;GO:0008047,molecular_function enzyme activator activity;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0042791,biological_process 5S class rRNA transcription from RNA polymerase III type 1 promoter;GO:0042797,biological_process tRNA transcription from RNA polymerase III promoter;GO:0043085,biological_process positive regulation of catalytic activity	NA	general transcription factor IIIC subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:4667]
ENSG00000172269	31.23	35.35	31.58	32.89	32.65	34.39	-0.0193868886298834	5.501220738387	0.82969902704685	0.965141404030763	11:119096502-119108331:-	DPAGT1	18;GO:0003975,molecular_function UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity;GO:0003976,molecular_function UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006047,biological_process UDP-N-acetylglucosamine metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0006489,biological_process dolichyl diphosphate biosynthetic process;GO:0008963,molecular_function phospho-N-acetylmuramoyl-pentapeptide-transferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019348,biological_process dolichol metabolic process;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051259,biological_process protein oligomerization	ALG7; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [EC:2.7.8.15]; K01001	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:2995]
ENSG00000197702	48.95	45.59	46.18	44.66	48.00	50.79	-0.0150619473404	5.90902497984579	0.829848131125823	0.965141404030763	11:12377184-12530801:+	PARVA	16;GO:0002040,biological_process sprouting angiogenesis;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003779,molecular_function actin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0015629,cellular_component actin cytoskeleton;GO:0030027,cellular_component lamellipodium;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0070252,biological_process actin-mediated cell contraction;GO:0071670,biological_process smooth muscle cell chemotaxis	PARV; parvin; K06275	parvin alpha [Source:HGNC Symbol%3BAcc:HGNC:14652]
ENSG00000255423	2.68	1.76	1.62	1.74	2.79	1.21	0.113557295749667	0.816120949032012	0.829900678453746	0.965141404030763	3:73061658-73063337:+	EBLN2	NA	NA	endogenous Bornavirus like nucleoprotein 2 [Source:HGNC Symbol%3BAcc:HGNC:25493]
ENSG00000108963	18.01	17.91	18.97	17.58	17.86	19.22	0.0184265013218031	4.76390911894787	0.829974784729477	0.965141404030763	17:2030109-2043430:+	DPH1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008283,biological_process cell proliferation;GO:0016740,molecular_function transferase activity;GO:0017183,biological_process peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0030054,cellular_component cell junction	NA	diphthamide biosynthesis 1 [Source:HGNC Symbol%3BAcc:HGNC:3003]
ENSG00000108306	7.98	7.67	7.78	8.03	7.36	7.85	0.0257496982326639	3.43672091369376	0.830006748299472	0.965141404030763	17:39252643-39402523:-	FBXL20	7;GO:0000209,biological_process protein polyubiquitination;GO:0001662,biological_process behavioral fear response;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0043687,biological_process post-translational protein modification	NA	F-box and leucine rich repeat protein 20 [Source:HGNC Symbol%3BAcc:HGNC:24679]
ENSG00000197191	4.61	3.46	3.20	3.26	3.57	3.95	0.0846637312619827	1.13130684409365	0.830100374684013	0.965141404030763	9:137224634-137226311:+	CYSRT1	NA	NA	cysteine rich tail 1 [Source:HGNC Symbol%3BAcc:HGNC:30529]
ENSG00000174206	5.17	5.78	5.92	5.64	5.66	6.00	-0.0308863957229992	3.02846502582146	0.830147217202865	0.965141404030763	12:64186315-64222296:-	C12orf66	8;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0016020,cellular_component membrane;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042149,biological_process cellular response to glucose starvation;GO:0061462,biological_process protein localization to lysosome;GO:0140007,cellular_component KICSTOR complex;GO:1904262,biological_process negative regulation of TORC1 signaling	NA	chromosome 12 open reading frame 66 [Source:HGNC Symbol%3BAcc:HGNC:26517]
ENSG00000171928	44.52	45.59	42.21	45.54	43.73	45.66	-0.0194409228654187	4.82525407029216	0.830148233616549	0.965141404030763	17:18780994-18806714:+	TVP23B	5;GO:0009306,biological_process protein secretion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030173,cellular_component integral component of Golgi membrane	NA	trans-golgi network vesicle protein 23 homolog B [Source:HGNC Symbol%3BAcc:HGNC:20399]
ENSG00000122678	5.66	7.52	6.24	6.08	6.58	6.45	0.0215283469248309	3.68088551353156	0.83015608559559	0.965141404030763	7:44072246-44082540:-	POLM	16;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0030183,biological_process B cell differentiation;GO:0034061,molecular_function DNA polymerase activity;GO:0046872,molecular_function metal ion binding;GO:0071897,biological_process DNA biosynthetic process	POLM; DNA polymerase mu [EC:2.7.7.7]; K03513	DNA polymerase mu [Source:HGNC Symbol%3BAcc:HGNC:9185]
ENSG00000118564	33.66	33.34	34.35	34.73	30.91	35.46	0.0151778462813397	6.17147423301925	0.830163116960965	0.965141404030763	4:15604538-15681679:-	FBXL5	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006879,biological_process cellular iron ion homeostasis;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055072,biological_process iron ion homeostasis;GO:1903364,biological_process positive regulation of cellular protein catabolic process	NA	F-box and leucine rich repeat protein 5 [Source:HGNC Symbol%3BAcc:HGNC:13602]
ENSG00000094631	19.89	20.99	19.27	19.30	20.96	19.72	0.0138930726409056	6.19325811568385	0.830378139040289	0.96523412233274	X:48801376-48824982:+	HDAC6	97;GO:0000118,cellular_component histone deacetylase complex;GO:0000209,biological_process protein polyubiquitination;GO:0001047,molecular_function core promoter binding;GO:0003779,molecular_function actin binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005771,cellular_component multivesicular body;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005901,cellular_component caveola;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006476,biological_process protein deacetylation;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006515,biological_process misfolded or incompletely synthesized protein catabolic process;GO:0006886,biological_process intracellular protein transport;GO:0006914,biological_process autophagy;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0008013,molecular_function beta-catenin binding;GO:0008017,molecular_function microtubule binding;GO:0008270,molecular_function zinc ion binding;GO:0009636,biological_process response to toxic substance;GO:0009967,biological_process positive regulation of signal transduction;GO:0010033,biological_process response to organic substance;GO:0010469,biological_process regulation of receptor activity;GO:0010506,biological_process regulation of autophagy;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010727,biological_process negative regulation of hydrogen peroxide metabolic process;GO:0010870,biological_process positive regulation of receptor biosynthetic process;GO:0016234,cellular_component inclusion body;GO:0016235,cellular_component aggresome;GO:0016241,biological_process regulation of macroautophagy;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0030286,cellular_component dynein complex;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031252,cellular_component cell leading edge;GO:0031593,molecular_function polyubiquitin binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0032418,biological_process lysosome localization;GO:0034983,biological_process peptidyl-lysine deacetylation;GO:0035967,biological_process cellular response to topologically incorrect protein;GO:0040029,biological_process regulation of gene expression, epigenetic;GO:0042826,molecular_function histone deacetylase binding;GO:0042903,molecular_function tubulin deacetylase activity;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043014,molecular_function alpha-tubulin binding;GO:0043130,molecular_function ubiquitin binding;GO:0043162,biological_process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043204,cellular_component perikaryon;GO:0043234,cellular_component protein complex;GO:0043241,biological_process protein complex disassembly;GO:0043242,biological_process negative regulation of protein complex disassembly;GO:0044297,cellular_component cell body;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045861,biological_process negative regulation of proteolysis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048156,molecular_function tau protein binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048487,molecular_function beta-tubulin binding;GO:0048668,biological_process collateral sprouting;GO:0051354,biological_process negative regulation of oxidoreductase activity;GO:0051646,biological_process mitochondrion localization;GO:0051787,molecular_function misfolded protein binding;GO:0051788,biological_process response to misfolded protein;GO:0051879,molecular_function Hsp90 protein binding;GO:0060271,biological_process cilium morphogenesis;GO:0060632,biological_process regulation of microtubule-based movement;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0060997,biological_process dendritic spine morphogenesis;GO:0061734,biological_process parkin-mediated mitophagy in response to mitochondrial depolarization;GO:0070201,biological_process regulation of establishment of protein localization;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0070840,molecular_function dynein complex binding;GO:0070842,biological_process aggresome assembly;GO:0070845,biological_process polyubiquitinated misfolded protein transport;GO:0070846,biological_process Hsp90 deacetylation;GO:0070848,biological_process response to growth factor;GO:0070932,biological_process histone H3 deacetylation;GO:0071218,biological_process cellular response to misfolded protein;GO:0090035,biological_process positive regulation of chaperone-mediated protein complex assembly;GO:0090042,biological_process tubulin deacetylation;GO:0098779,biological_process mitophagy in response to mitochondrial depolarization;GO:1901300,biological_process positive regulation of hydrogen peroxide-mediated programmed cell death;GO:1903146,biological_process regulation of mitophagy	HDAC6; histone deacetylase 6 [EC:3.5.1.98]; K11407	histone deacetylase 6 [Source:HGNC Symbol%3BAcc:HGNC:14064]
ENSG00000123636	5.80	5.59	6.06	5.89	5.65	5.87	0.0171701075590185	5.27590713279123	0.830398388172991	0.96523412233274	2:159318978-159616692:-	BAZ2B	6;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	bromodomain adjacent to zinc finger domain 2B [Source:HGNC Symbol%3BAcc:HGNC:963]
ENSG00000115956	6.19	5.82	4.28	4.42	6.14	5.36	0.0416054430779519	2.53068118740026	0.830700405633006	0.965469707371323	2:68365172-68397453:+	PLEK	33;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002576,biological_process platelet degranulation;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0010572,biological_process positive regulation of platelet activation;GO:0010920,biological_process negative regulation of inositol phosphate biosynthetic process;GO:0010925,biological_process positive regulation of inositol-polyphosphate 5-phosphatase activity;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0030836,biological_process positive regulation of actin filament depolymerization;GO:0030845,biological_process phospholipase C-inhibiting G-protein coupled receptor signaling pathway;GO:0030866,biological_process cortical actin cytoskeleton organization;GO:0031529,biological_process ruffle organization;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0032587,cellular_component ruffle membrane;GO:0033625,biological_process positive regulation of integrin activation;GO:0035556,biological_process intracellular signal transduction;GO:0042803,molecular_function protein homodimerization activity;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0045744,biological_process negative regulation of G-protein coupled receptor protein signaling pathway;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0050849,biological_process negative regulation of calcium-mediated signaling;GO:0060305,biological_process regulation of cell diameter;GO:0070493,biological_process thrombin receptor signaling pathway;GO:0070527,biological_process platelet aggregation;GO:0070528,biological_process protein kinase C signaling;GO:0070560,biological_process protein secretion by platelet	NA	pleckstrin [Source:HGNC Symbol%3BAcc:HGNC:9070]
ENSG00000169951	2.60	2.81	2.65	2.51	3.47	2.41	-0.0482908970585836	1.80640984638509	0.831067029433908	0.965469707371323	16:30553763-30558498:-	ZNF764	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 764 [Source:HGNC Symbol%3BAcc:HGNC:28200]
ENSG00000214160	24.49	26.71	23.79	24.09	25.72	24.77	0.0148289309106056	5.17266112777892	0.83109078516078	0.965469707371323	3:184242300-184249548:-	ALG3	13;GO:0000033,molecular_function alpha-1,3-mannosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0052925,molecular_function dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity;GO:0097502,biological_process mannosylation	ALG3; alpha-1,3-mannosyltransferase [EC:2.4.1.258]; K03845	ALG3%2C alpha-1%2C3- mannosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:23056]
ENSG00000142512	0.37	0.59	0.35	0.39	0.47	0.57	-0.156800394688097	0.140626583487471	0.831187582824807	0.965469707371323	19:51410020-51417803:-	SIGLEC10	6;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding	NA	sialic acid binding Ig like lectin 10 [Source:HGNC Symbol%3BAcc:HGNC:15620]
ENSG00000109927	0.28	0.31	0.13	0.13	0.29	0.25	0.0919622065444286	0.709170986579085	0.831192784565434	0.965469707371323	11:121101172-121191493:+	TECTA	10;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005886,cellular_component plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0007160,biological_process cell-matrix adhesion;GO:0007605,biological_process sensory perception of sound;GO:0016020,cellular_component membrane;GO:0031225,cellular_component anchored component of membrane;GO:0070062,cellular_component extracellular exosome	NA	tectorin alpha [Source:HGNC Symbol%3BAcc:HGNC:11720]
ENSG00000169857	12.75	9.68	11.52	12.69	11.73	10.68	-0.0239522474015014	3.66777828694891	0.831237227988059	0.965469707371323	15:33866226-34039176:-	AVEN	6;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006915,biological_process apoptotic process;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0043066,biological_process negative regulation of apoptotic process	NA	apoptosis and caspase activation inhibitor [Source:HGNC Symbol%3BAcc:HGNC:13509]
ENSG00000108821	0.22	0.17	0.19	0.28	0.23	0.12	-0.0975485635114833	0.106608857320973	0.831310851753043	0.965469707371323	17:50183288-50201632:-	COL1A1	73;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001568,biological_process blood vessel development;GO:0001649,biological_process osteoblast differentiation;GO:0001957,biological_process intramembranous ossification;GO:0001958,biological_process endochondral ossification;GO:0002020,molecular_function protease binding;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005584,cellular_component collagen type I trimer;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0007584,biological_process response to nutrient;GO:0007596,biological_process blood coagulation;GO:0007601,biological_process visual perception;GO:0007605,biological_process sensory perception of sound;GO:0009612,biological_process response to mechanical stimulus;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0015031,biological_process protein transport;GO:0030141,cellular_component secretory granule;GO:0030168,biological_process platelet activation;GO:0030198,biological_process extracellular matrix organization;GO:0030199,biological_process collagen fibril organization;GO:0030335,biological_process positive regulation of cell migration;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0031667,biological_process response to nutrient levels;GO:0031960,biological_process response to corticosteroid;GO:0032355,biological_process response to estradiol;GO:0032964,biological_process collagen biosynthetic process;GO:0034504,biological_process protein localization to nucleus;GO:0034505,biological_process tooth mineralization;GO:0038063,biological_process collagen-activated tyrosine kinase receptor signaling pathway;GO:0042060,biological_process wound healing;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0043434,biological_process response to peptide hormone;GO:0043588,biological_process skin development;GO:0043589,biological_process skin morphogenesis;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0044691,biological_process tooth eruption;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048407,molecular_function platelet-derived growth factor binding;GO:0048545,biological_process response to steroid hormone;GO:0048705,biological_process skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0050776,biological_process regulation of immune response;GO:0050900,biological_process leukocyte migration;GO:0051591,biological_process response to cAMP;GO:0055093,biological_process response to hyperoxia;GO:0060325,biological_process face morphogenesis;GO:0060346,biological_process bone trabecula formation;GO:0060351,biological_process cartilage development involved in endochondral bone morphogenesis;GO:0070208,biological_process protein heterotrimerization;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071300,biological_process cellular response to retinoic acid;GO:0071306,biological_process cellular response to vitamin E;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902617,biological_process response to fluoride;GO:1902618,biological_process cellular response to fluoride	NA	collagen type I alpha 1 chain [Source:HGNC Symbol%3BAcc:HGNC:2197]
ENSG00000109099	90.32	78.31	94.52	91.78	79.97	90.58	0.0193645667490609	6.04949733942503	0.831483352349433	0.965469707371323	17:15229776-15265326:-	PMP22	14;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007268,biological_process chemical synaptic transmission;GO:0007422,biological_process peripheral nervous system development;GO:0008219,biological_process cell death;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0032060,biological_process bleb assembly;GO:0042552,biological_process myelination;GO:0043218,cellular_component compact myelin	NA	peripheral myelin protein 22 [Source:HGNC Symbol%3BAcc:HGNC:9118]
ENSG00000159216	19.54	18.02	19.13	19.85	16.91	19.69	0.0204103410913824	4.87280817538662	0.8316088784087	0.965469707371323	21:34787800-36004667:-	RUNX1	35;GO:0000975,molecular_function regulatory region DNA binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001503,biological_process ossification;GO:0001959,biological_process regulation of cytokine-mediated signaling pathway;GO:0002062,biological_process chondrocyte differentiation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030097,biological_process hemopoiesis;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030854,biological_process positive regulation of granulocyte differentiation;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045589,biological_process regulation of regulatory T cell differentiation;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048935,biological_process peripheral nervous system neuron development;GO:0050855,biological_process regulation of B cell receptor signaling pathway;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:2000810,biological_process regulation of bicellular tight junction assembly	RUNX1, AML1; runt-related transcription factor 1; K08367	runt related transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:10471]
ENSG00000187118	54.12	45.96	50.94	53.34	50.11	47.09	0.0239759344802721	4.49636702088626	0.831677074327275	0.965469707371323	3:28241583-28325142:+	CMC1	2;GO:0005739,cellular_component mitochondrion;GO:0046872,molecular_function metal ion binding	NA	C-X9-C motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28783]
ENSG00000213588	7.07	8.49	7.68	7.07	7.96	8.77	-0.0338549401764767	3.49276919141402	0.83184799642469	0.965469707371323	6:33453969-33457548:+	ZBTB9	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:28323]
ENSG00000106290	58.12	53.21	57.37	58.30	57.77	55.75	-0.0130794203909799	7.00235465576861	0.83188080731066	0.965469707371323	7:100107069-100119841:-	TAF6	22;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0017162,molecular_function aryl hydrocarbon receptor binding;GO:0033276,cellular_component transcription factor TFTC complex;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0043234,cellular_component protein complex;GO:0045786,biological_process negative regulation of cell cycle;GO:0046982,molecular_function protein heterodimerization activity;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0071339,cellular_component MLL1 complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF6; transcription initiation factor TFIID subunit 6; K03131	TATA-box binding protein associated factor 6 [Source:HGNC Symbol%3BAcc:HGNC:11540]
ENSG00000213638	1.41	1.74	2.01	1.56	2.34	1.60	-0.0825153923849837	1.07262927358372	0.831885044755752	0.965469707371323	19:1905377-1913447:+	ADAT3	1;GO:0003824,molecular_function catalytic activity	NA	adenosine deaminase%2C tRNA specific 3 [Source:HGNC Symbol%3BAcc:HGNC:25151]
ENSG00000171951	0.42	0.62	0.48	0.44	0.61	0.61	-0.152755863024074	0.173296518496998	0.831998741954117	0.965469707371323	2:223596939-223602503:-	SCG2	24;GO:0000165,biological_process MAPK cascade;GO:0001525,biological_process angiogenesis;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006954,biological_process inflammatory response;GO:0009306,biological_process protein secretion;GO:0030141,cellular_component secretory granule;GO:0031045,cellular_component dense core granule;GO:0035556,biological_process intracellular signal transduction;GO:0042056,molecular_function chemoattractant activity;GO:0043542,biological_process endothelial cell migration;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0048245,biological_process eosinophil chemotaxis;GO:0050918,biological_process positive chemotaxis;GO:0050930,biological_process induction of positive chemotaxis;GO:0098992,cellular_component neuronal dense core vesicle;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	secretogranin II [Source:HGNC Symbol%3BAcc:HGNC:10575]
ENSG00000006210	6.25	6.09	5.72	6.50	5.33	6.80	-0.0369954654186551	2.91825027318773	0.832050595120078	0.965469707371323	16:57372457-57385048:+	CX3CL1	42;GO:0002523,biological_process leukocyte migration involved in inflammatory response;GO:0002548,biological_process monocyte chemotaxis;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006935,biological_process chemotaxis;GO:0006952,biological_process defense response;GO:0006955,biological_process immune response;GO:0007155,biological_process cell adhesion;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008009,molecular_function chemokine activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030336,biological_process negative regulation of cell migration;GO:0030593,biological_process neutrophil chemotaxis;GO:0030595,biological_process leukocyte chemotaxis;GO:0031737,molecular_function CX3C chemokine receptor binding;GO:0032914,biological_process positive regulation of transforming growth factor beta1 production;GO:0033622,biological_process integrin activation;GO:0042060,biological_process wound healing;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045766,biological_process positive regulation of angiogenesis;GO:0048020,molecular_function CCR chemokine receptor binding;GO:0048246,biological_process macrophage chemotaxis;GO:0048247,biological_process lymphocyte chemotaxis;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050902,biological_process leukocyte adhesive activation;GO:0051041,biological_process positive regulation of calcium-independent cell-cell adhesion;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0060326,biological_process cell chemotaxis;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	CX3CL1, NTT; C-X3-C motif chemokine 1; K05508	C-X3-C motif chemokine ligand 1 [Source:HGNC Symbol%3BAcc:HGNC:10647]
ENSG00000116691	13.17	11.00	12.96	12.29	13.62	12.32	-0.0198980319638367	3.88987844704501	0.832055744660222	0.965469707371323	1:12019465-12032045:+	MIIP	3;GO:0005515,molecular_function protein binding;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0030336,biological_process negative regulation of cell migration	NA	migration and invasion inhibitory protein [Source:HGNC Symbol%3BAcc:HGNC:25715]
ENSG00000119522	7.10	8.17	8.29	8.41	7.48	7.49	0.019589802903335	4.6235329867881	0.832142653521425	0.965469707371323	9:123379653-123930152:-	DENND1A	28;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017124,molecular_function SH3 domain binding;GO:0017137,molecular_function Rab GTPase binding;GO:0030054,cellular_component cell junction;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030425,cellular_component dendrite;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0032456,biological_process endocytic recycling;GO:0032483,biological_process regulation of Rab protein signal transduction;GO:0042734,cellular_component presynaptic membrane;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0061024,biological_process membrane organization;GO:1901981,molecular_function phosphatidylinositol phosphate binding	NA	DENN domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:29324]
ENSG00000151366	29.09	27.98	22.65	25.27	29.17	27.57	-0.0318841349538889	3.46083946276393	0.832175090048592	0.965469707371323	11:78068303-78080219:-	NDUFC2	14;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005886,cellular_component plasma membrane;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2; K03968	NADH:ubiquinone oxidoreductase subunit C2 [Source:HGNC Symbol%3BAcc:HGNC:7706]
ENSG00000204304	37.06	34.67	36.17	36.62	36.98	36.41	-0.0134998586640243	5.55654600188701	0.832179074614332	0.965469707371323	6:32184740-32190186:-	PBX2	16;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0009954,biological_process proximal/distal pattern formation;GO:0030326,biological_process embryonic limb morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	PBX homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:8633]
ENSG00000182944	147.79	146.27	144.72	145.75	150.51	149.88	-0.0121928176094651	8.33828379714967	0.832247998577304	0.965469707371323	22:29268008-29300525:+	EWSR1	13;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	EWSR1; RNA-binding protein EWS; K13209	EWS RNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:3508]
ENSG00000117614	105.79	97.66	107.02	107.43	101.23	107.74	-0.0133612059830661	6.2558858221629	0.83230972855552	0.965469707371323	1:25222678-25232502:-	SYF2	17;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000974,cellular_component Prp19 complex;GO:0001701,biological_process in utero embryonic development;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0007369,biological_process gastrulation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0048568,biological_process embryonic organ development;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0071014,cellular_component post-mRNA release spliceosomal complex	SYF2; pre-mRNA-splicing factor SYF2; K12868	SYF2 pre-mRNA splicing factor [Source:HGNC Symbol%3BAcc:HGNC:19824]
ENSG00000115947	48.49	48.66	47.55	45.85	49.52	51.99	-0.0154263998508699	5.99685363831895	0.832332550448878	0.965469707371323	2:147930396-148021604:-	ORC4	15;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000808,cellular_component origin recognition complex;GO:0003677,molecular_function DNA binding;GO:0003688,molecular_function DNA replication origin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation	ORC4; origin recognition complex subunit 4; K02606	origin recognition complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:8490]
ENSG00000198919	12.61	11.10	13.71	11.30	14.02	11.91	0.0230115665097094	5.50259192625418	0.832389978916289	0.965469707371323	3:108589681-108694846:+	DZIP3	20;GO:0000209,biological_process protein polyubiquitination;GO:0000836,cellular_component Hrd1p ubiquitin ligase complex;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019902,molecular_function phosphatase binding;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0031593,molecular_function polyubiquitin binding;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:0051082,molecular_function unfolded protein binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1990381,molecular_function ubiquitin-specific protease binding	NA	DAZ interacting zinc finger protein 3 [Source:HGNC Symbol%3BAcc:HGNC:30938]
ENSG00000154781	18.97	17.00	21.13	19.42	17.74	21.38	-0.019898359737373	4.77804238417816	0.832632979378968	0.965521833304026	3:14651745-14672659:+	CCDC174	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm	NA	coiled-coil domain containing 174 [Source:HGNC Symbol%3BAcc:HGNC:28033]
ENSG00000180979	10.93	10.66	10.57	11.38	9.10	11.18	0.0335180638830763	2.96137507990061	0.832665324807596	0.965521833304026	15:42537819-42548802:-	LRRC57	2;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	NA	leucine rich repeat containing 57 [Source:HGNC Symbol%3BAcc:HGNC:26719]
ENSG00000180573	32.60	22.30	29.82	33.21	23.92	30.65	-0.0289058251678686	3.51785624766697	0.832720448619569	0.965521833304026	6:26124144-26139116:+	HIST1H2AC	10;GO:0000786,cellular_component nucleosome;GO:0000790,cellular_component nuclear chromatin;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006342,biological_process chromatin silencing;GO:0008285,biological_process negative regulation of cell proliferation;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome	H2A; histone H2A; K11251	histone cluster 1 H2A family member c [Source:HGNC Symbol%3BAcc:HGNC:4733]
ENSG00000120837	46.75	47.63	44.51	45.99	46.95	45.32	0.0164194283562345	4.87028708165144	0.832746052312326	0.965521833304026	12:104117076-104138289:-	NFYB	19;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016602,cellular_component CCAAT-binding factor complex;GO:0032403,molecular_function protein complex binding;GO:0032993,cellular_component protein-DNA complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0070491,molecular_function repressing transcription factor binding;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NFYB; nuclear transcription Y subunit beta; K08065	nuclear transcription factor Y subunit beta [Source:HGNC Symbol%3BAcc:HGNC:7805]
ENSG00000090565	18.61	18.36	18.76	19.27	17.05	19.25	0.0159567734326531	5.49745585567617	0.833047902015961	0.965762727115253	16:425618-523011:+	RAB11FIP3	30;GO:0000910,biological_process cytokinesis;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017137,molecular_function Rab GTPase binding;GO:0030306,molecular_function ADP-ribosylation factor binding;GO:0030496,cellular_component midbody;GO:0032154,cellular_component cleavage furrow;GO:0032456,biological_process endocytic recycling;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045171,cellular_component intercellular bridge;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061512,biological_process protein localization to cilium;GO:0070164,biological_process negative regulation of adiponectin secretion	RAB11FIP3_4; Rab11 family-interacting protein 3/4; K12485	RAB11 family interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:17224]
ENSG00000172183	4.05	3.48	4.09	4.03	3.16	4.03	0.0701848100850894	1.23587935133548	0.833109424148081	0.965762727115253	15:88636152-88656483:+	ISG20	29;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000738,biological_process DNA catabolic process, exonucleolytic;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0006401,biological_process RNA catabolic process;GO:0008283,biological_process cell proliferation;GO:0008310,molecular_function single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0008859,molecular_function exoribonuclease II activity;GO:0009615,biological_process response to virus;GO:0015030,cellular_component Cajal body;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0030619,molecular_function U1 snRNA binding;GO:0030620,molecular_function U2 snRNA binding;GO:0034511,molecular_function U3 snoRNA binding;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	interferon stimulated exonuclease gene 20 [Source:HGNC Symbol%3BAcc:HGNC:6130]
ENSG00000169139	124.84	117.17	116.01	124.83	121.44	118.34	-0.0133968715406202	6.26561113752738	0.833255945698676	0.965822020031796	8:48008399-48064708:+	UBE2V2	24;GO:0000209,biological_process protein polyubiquitination;GO:0000729,biological_process DNA double-strand break processing;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006282,biological_process regulation of DNA repair;GO:0006301,biological_process postreplication repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0008283,biological_process cell proliferation;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016567,biological_process protein ubiquitination;GO:0031372,cellular_component UBC13-MMS2 complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042275,biological_process error-free postreplication DNA repair;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045739,biological_process positive regulation of DNA repair;GO:0051965,biological_process positive regulation of synapse assembly;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070062,cellular_component extracellular exosome;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070911,biological_process global genome nucleotide-excision repair	UBE2V; ubiquitin-conjugating enzyme E2 variant; K10704	ubiquitin conjugating enzyme E2 V2 [Source:HGNC Symbol%3BAcc:HGNC:12495]
ENSG00000117118	77.12	76.56	73.43	73.75	76.37	76.62	0.013493987526284	6.04424459230524	0.83331618742774	0.965822020031796	1:17018721-17054170:-	SDHB	24;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005749,cellular_component mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0005886,cellular_component plasma membrane;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006105,biological_process succinate metabolic process;GO:0008177,molecular_function succinate dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0022904,biological_process respiratory electron transport chain;GO:0031966,cellular_component mitochondrial membrane;GO:0045273,cellular_component respiratory chain complex II;GO:0046872,molecular_function metal ion binding;GO:0048039,molecular_function ubiquinone binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0051538,molecular_function 3 iron, 4 sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]; K00235	succinate dehydrogenase complex iron sulfur subunit B [Source:HGNC Symbol%3BAcc:HGNC:10681]
ENSG00000162437	7.19	7.98	6.25	8.60	6.62	6.75	-0.0312032678040455	3.91656797697852	0.833401512302501	0.965830732164219	1:64745094-64833232:+	RAVER2	5;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm	NA	ribonucleoprotein%2C PTB binding 2 [Source:HGNC Symbol%3BAcc:HGNC:25577]
ENSG00000100417	59.85	55.34	61.39	61.20	53.46	61.47	0.0175662346125745	5.72862223274913	0.833480163779065	0.965831709577067	22:41576893-41589890:-	PMM1	12;GO:0004615,molecular_function phosphomannomutase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006013,biological_process mannose metabolic process;GO:0006487,biological_process protein N-linked glycosylation;GO:0009298,biological_process GDP-mannose biosynthetic process;GO:0016853,molecular_function isomerase activity;GO:0043025,cellular_component neuronal cell body;GO:0045047,biological_process protein targeting to ER;GO:0046872,molecular_function metal ion binding;GO:1990830,biological_process cellular response to leukemia inhibitory factor	manB; phosphomannomutase [EC:5.4.2.8]; K01840	phosphomannomutase 1 [Source:HGNC Symbol%3BAcc:HGNC:9114]
ENSG00000183576	40.59	40.65	39.03	41.04	38.33	40.68	0.0134696187382716	6.21346868433431	0.833599639819802	0.965879989646523	14:99397745-99480889:-	SETD3	24;GO:0000790,cellular_component nuclear chromatin;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0010452,biological_process histone H3-K36 methylation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0018023,biological_process peptidyl-lysine trimethylation;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0018026,biological_process peptidyl-lysine monomethylation;GO:0018027,biological_process peptidyl-lysine dimethylation;GO:0032259,biological_process methylation;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046975,molecular_function histone methyltransferase activity (H3-K36 specific);GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051568,biological_process histone H3-K4 methylation;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	SET domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:20493]
ENSG00000047315	56.14	59.64	54.40	56.74	60.07	56.35	-0.0141166032447335	7.65986912476364	0.833844217452736	0.965981899913098	4:56977721-57031168:+	POLR2B	28;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001055,molecular_function RNA polymerase II activity;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032549,molecular_function ribonucleoside binding;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB2, POLR2B; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]; K03010	RNA polymerase II subunit B [Source:HGNC Symbol%3BAcc:HGNC:9188]
ENSG00000100325	16.90	18.83	19.20	18.38	20.34	17.34	-0.0184522450381769	5.51317149410397	0.833897757395803	0.965981899913098	22:29788607-29838304:-	ASCC2	6;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0099053,cellular_component activating signal cointegrator 1 complex	NA	activating signal cointegrator 1 complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:24103]
ENSG00000112039	2.37	2.50	2.70	2.42	2.50	2.49	0.0411462364733971	2.05930118639145	0.833921053691191	0.965981899913098	6:35452360-35467103:+	FANCE	7;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex	FANCE; fanconi anemia group E protein; K10892	Fanconi anemia complementation group E [Source:HGNC Symbol%3BAcc:HGNC:3586]
ENSG00000075420	36.74	35.49	37.72	37.64	34.96	37.23	0.0138906683336737	7.0728527947108	0.83401793180047	0.966003973820961	3:172039627-172401665:+	FNDC3B	3;GO:0003723,molecular_function RNA binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	fibronectin type III domain containing 3B [Source:HGNC Symbol%3BAcc:HGNC:24670]
ENSG00000183309	20.69	19.49	17.48	19.98	17.50	21.47	-0.0213347849676523	4.97441784441937	0.834546436050278	0.966520059866882	8:143636012-143656418:+	ZNF623	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 623 [Source:HGNC Symbol%3BAcc:HGNC:29084]
ENSG00000101945	5.87	6.31	5.26	5.52	5.12	6.44	0.0300052696091517	2.91690724225833	0.834831057703217	0.966520059866882	X:48695553-48709012:+	SUV39H1	40;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000775,cellular_component chromosome, centromeric region;GO:0000792,cellular_component heterochromatin;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005652,cellular_component nuclear lamina;GO:0005654,cellular_component nucleoplasm;GO:0005677,cellular_component chromatin silencing complex;GO:0005694,cellular_component chromosome;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016032,biological_process viral process;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030154,biological_process cell differentiation;GO:0032259,biological_process methylation;GO:0033553,cellular_component rDNA heterochromatin;GO:0034968,biological_process histone lysine methylation;GO:0036123,biological_process histone H3-K9 dimethylation;GO:0036124,biological_process histone H3-K9 trimethylation;GO:0042054,molecular_function histone methyltransferase activity;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046974,molecular_function histone methyltransferase activity (H3-K9 specific);GO:0047485,molecular_function protein N-terminus binding;GO:0048511,biological_process rhythmic process;GO:0071456,biological_process cellular response to hypoxia	SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]; K11419	suppressor of variegation 3-9 homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:11479]
ENSG00000133250	6.20	5.49	4.74	4.71	5.65	5.79	0.0368126180904433	2.83890158052907	0.83498913038422	0.966520059866882	19:8509677-8514164:-	ZNF414	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 414 [Source:HGNC Symbol%3BAcc:HGNC:20630]
ENSG00000131188	17.53	14.18	16.03	13.66	14.49	18.99	0.0342499157339197	3.72441262295242	0.835026392920664	0.966520059866882	5:177446444-177456286:+	PRR7	6;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	proline rich 7%2C synaptic [Source:HGNC Symbol%3BAcc:HGNC:28130]
ENSG00000154134	2.16	1.48	2.09	1.92	1.73	2.03	0.040753111789208	3.0558078796266	0.835066196163829	0.966520059866882	11:124865385-124881470:+	ROBO3	10;GO:0006935,biological_process chemotaxis;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016199,biological_process axon midline choice point recognition;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0035385,biological_process Roundabout signaling pathway	ROBO3; roundabout, axon guidance receptor 3; K06755	roundabout guidance receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:13433]
ENSG00000129187	44.04	40.64	40.29	38.73	44.35	41.42	0.019604534982596	4.86401214590189	0.835182082583608	0.966520059866882	4:182890059-182917936:-	DCTD	16;GO:0003824,molecular_function catalytic activity;GO:0004132,molecular_function dCMP deaminase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006220,biological_process pyrimidine nucleotide metabolic process;GO:0006226,biological_process dUMP biosynthetic process;GO:0006231,biological_process dTMP biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009165,biological_process nucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	comEB; dCMP deaminase [EC:3.5.4.12]; K01493	dCMP deaminase [Source:HGNC Symbol%3BAcc:HGNC:2710]
ENSG00000113360	29.66	31.02	29.77	30.30	30.32	31.37	-0.0137308718514206	6.97203271407199	0.835239683560746	0.966520059866882	5:31400496-31532196:-	DROSHA	39;GO:0001530,molecular_function lipopolysaccharide binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0004525,molecular_function ribonuclease III activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006396,biological_process RNA processing;GO:0010468,biological_process regulation of gene expression;GO:0010586,biological_process miRNA metabolic process;GO:0010628,biological_process positive regulation of gene expression;GO:0016075,biological_process rRNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0017151,molecular_function DEAD/H-box RNA helicase binding;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0031047,biological_process gene silencing by RNA;GO:0031053,biological_process primary miRNA processing;GO:0031054,biological_process pre-miRNA processing;GO:0042254,biological_process ribosome biogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0045589,biological_process regulation of regulatory T cell differentiation;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0050727,biological_process regulation of inflammatory response;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0070412,molecular_function R-SMAD binding;GO:0070877,cellular_component microprocessor complex;GO:0070878,molecular_function primary miRNA binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:2000628,biological_process regulation of miRNA metabolic process	rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]; K03685	drosha ribonuclease III [Source:HGNC Symbol%3BAcc:HGNC:17904]
ENSG00000189171	266.65	255.17	264.61	273.51	259.00	268.12	-0.0129450089581547	6.28529926111521	0.835278966982368	0.966520059866882	1:153618786-153631360:-	S100A13	29;GO:0005507,molecular_function copper ion binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008360,biological_process regulation of cell shape;GO:0015031,biological_process protein transport;GO:0017134,molecular_function fibroblast growth factor binding;GO:0042629,cellular_component mast cell granule;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043303,biological_process mast cell degranulation;GO:0046688,biological_process response to copper ion;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050663,biological_process cytokine secretion;GO:0050703,biological_process interleukin-1 alpha secretion;GO:0050786,molecular_function RAGE receptor binding;GO:0051602,biological_process response to electrical stimulus;GO:0070062,cellular_component extracellular exosome	NA	S100 calcium binding protein A13 [Source:HGNC Symbol%3BAcc:HGNC:10490]
ENSG00000114956	62.98	53.36	61.47	64.24	57.77	59.66	-0.0144956888349748	5.64529619196062	0.83528721153943	0.966520059866882	2:73926825-73958961:+	DGUOK	21;GO:0000166,molecular_function nucleotide binding;GO:0004138,molecular_function deoxyguanosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006468,biological_process protein phosphorylation;GO:0008617,biological_process guanosine metabolic process;GO:0009157,biological_process deoxyribonucleoside monophosphate biosynthetic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0043101,biological_process purine-containing compound salvage;GO:0046070,biological_process dGTP metabolic process;GO:0046122,biological_process purine deoxyribonucleoside metabolic process	DGUOK; deoxyguanosine kinase [EC:2.7.1.113]; K00904	deoxyguanosine kinase [Source:HGNC Symbol%3BAcc:HGNC:2858]
ENSG00000173124	0.61	0.38	0.98	0.60	0.56	0.70	0.134022491690228	0.172183294824538	0.835304788032086	0.966520059866882	10:95194199-95228928:+	ACSM6	19;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003996,molecular_function acyl-CoA ligase activity;GO:0004321,molecular_function fatty-acyl-CoA synthase activity;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0008152,biological_process metabolic process;GO:0015645,molecular_function fatty acid ligase activity;GO:0016874,molecular_function ligase activity;GO:0031647,biological_process regulation of protein stability;GO:0046872,molecular_function metal ion binding;GO:0047760,molecular_function butyrate-CoA ligase activity;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	acyl-CoA synthetase medium chain family member 6 [Source:HGNC Symbol%3BAcc:HGNC:31665]
ENSG00000169282	0.53	0.51	0.55	0.68	0.57	0.49	-0.106815908952363	0.251812218133195	0.83532354002357	0.966520059866882	3:156037700-156539138:+	KCNAB1	40;GO:0004033,molecular_function aldo-keto reductase (NADP) activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007519,biological_process skeletal muscle tissue development;GO:0007611,biological_process learning or memory;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019904,molecular_function protein domain specific binding;GO:0030424,cellular_component axon;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0032839,cellular_component dendrite cytoplasm;GO:0034705,cellular_component potassium channel complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0043025,cellular_component neuronal cell body;GO:0043204,cellular_component perikaryon;GO:0044224,cellular_component juxtaparanode region of axon;GO:0044325,molecular_function ion channel binding;GO:0045445,biological_process myoblast differentiation;GO:0055085,biological_process transmembrane transport;GO:0055114,biological_process oxidation-reduction process;GO:0060539,biological_process diaphragm development;GO:0070402,molecular_function NADPH binding;GO:0071805,biological_process potassium ion transmembrane transport;GO:1901016,biological_process regulation of potassium ion transmembrane transporter activity;GO:1901379,biological_process regulation of potassium ion transmembrane transport;GO:1902259,biological_process regulation of delayed rectifier potassium channel activity;GO:1902260,biological_process negative regulation of delayed rectifier potassium channel activity;GO:1903817,biological_process negative regulation of voltage-gated potassium channel activity;GO:1990635,cellular_component proximal dendrite	NA	potassium voltage-gated channel subfamily A member regulatory beta subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:6228]
ENSG00000112658	13.49	14.49	15.21	13.46	14.83	14.63	0.0190733970007975	4.46107461018014	0.835450700732326	0.966520059866882	6:43171298-43181507:+	SRF	106;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001569,biological_process patterning of blood vessels;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001707,biological_process mesoderm formation;GO:0001764,biological_process neuron migration;GO:0001829,biological_process trophectodermal cell differentiation;GO:0001947,biological_process heart looping;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0002521,biological_process leukocyte differentiation;GO:0003257,biological_process positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007015,biological_process actin filament organization;GO:0007160,biological_process cell-matrix adhesion;GO:0007275,biological_process multicellular organism development;GO:0007369,biological_process gastrulation;GO:0007507,biological_process heart development;GO:0007616,biological_process long-term memory;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008306,biological_process associative learning;GO:0009636,biological_process response to toxic substance;GO:0009725,biological_process response to hormone;GO:0010669,biological_process epithelial structure maintenance;GO:0010735,biological_process positive regulation of transcription via serum response element binding;GO:0010736,molecular_function serum response element binding;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0021766,biological_process hippocampus development;GO:0022028,biological_process tangential migration from the subventricular zone to the olfactory bulb;GO:0030036,biological_process actin cytoskeleton organization;GO:0030038,biological_process contractile actin filament bundle assembly;GO:0030155,biological_process regulation of cell adhesion;GO:0030168,biological_process platelet activation;GO:0030220,biological_process platelet formation;GO:0030336,biological_process negative regulation of cell migration;GO:0030878,biological_process thyroid gland development;GO:0030900,biological_process forebrain development;GO:0031175,biological_process neuron projection development;GO:0031490,molecular_function chromatin DNA binding;GO:0033561,biological_process regulation of water loss via skin;GO:0034097,biological_process response to cytokine;GO:0035855,biological_process megakaryocyte development;GO:0035912,biological_process dorsal aorta morphogenesis;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0042826,molecular_function histone deacetylase binding;GO:0043149,biological_process stress fiber assembly;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043589,biological_process skin morphogenesis;GO:0045059,biological_process positive thymic T cell selection;GO:0045214,biological_process sarcomere organization;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045773,biological_process positive regulation of axon extension;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045987,biological_process positive regulation of smooth muscle contraction;GO:0046016,biological_process positive regulation of transcription by glucose;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046983,molecular_function protein dimerization activity;GO:0048538,biological_process thymus development;GO:0048589,biological_process developmental growth;GO:0048666,biological_process neuron development;GO:0048821,biological_process erythrocyte development;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051150,biological_process regulation of smooth muscle cell differentiation;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0055003,biological_process cardiac myofibril assembly;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0060218,biological_process hematopoietic stem cell differentiation;GO:0060261,biological_process positive regulation of transcription initiation from RNA polymerase II promoter;GO:0060292,biological_process long term synaptic depression;GO:0060324,biological_process face development;GO:0060347,biological_process heart trabecula formation;GO:0060425,biological_process lung morphogenesis;GO:0060532,biological_process bronchus cartilage development;GO:0060534,biological_process trachea cartilage development;GO:0060947,biological_process cardiac vascular smooth muscle cell differentiation;GO:0061029,biological_process eyelid development in camera-type eye;GO:0061145,biological_process lung smooth muscle development;GO:0070830,biological_process bicellular tight junction assembly;GO:0070878,molecular_function primary miRNA binding;GO:0071333,biological_process cellular response to glucose stimulus;GO:0090009,biological_process primitive streak formation;GO:0090136,biological_process epithelial cell-cell adhesion;GO:0090398,biological_process cellular senescence;GO:1900222,biological_process negative regulation of beta-amyloid clearance;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter	SRF; serum response factor; K04378	serum response factor [Source:HGNC Symbol%3BAcc:HGNC:11291]
ENSG00000197451	124.66	137.98	121.49	132.45	131.96	118.47	0.0149539578268938	6.99406393837736	0.83547573047383	0.966520059866882	5:178204506-178211163:+	HNRNPAB	13;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0003676,molecular_function nucleic acid binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0090575,cellular_component RNA polymerase II transcription factor complex	NA	heterogeneous nuclear ribonucleoprotein A/B [Source:HGNC Symbol%3BAcc:HGNC:5034]
ENSG00000196683	264.81	245.20	263.98	274.63	245.42	268.35	-0.0138086644796514	6.96599486703675	0.836012222188432	0.96700233795535	7:22812627-22822852:-	TOMM7	18;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0008320,molecular_function protein transmembrane transporter activity;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016236,biological_process macroautophagy;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0031647,biological_process regulation of protein stability;GO:0045040,biological_process protein import into mitochondrial outer membrane;GO:0098779,biological_process mitophagy in response to mitochondrial depolarization;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	translocase of outer mitochondrial membrane 7 [Source:HGNC Symbol%3BAcc:HGNC:21648]
ENSG00000213793	11.15	11.93	11.48	11.19	11.65	11.52	0.0162527804967082	4.63746018283162	0.83604842430813	0.96700233795535	19:52904416-52923481:-	ZNF888	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 888 [Source:HGNC Symbol%3BAcc:HGNC:38695]
ENSG00000197044	4.99	5.05	5.06	4.93	4.48	5.51	0.0256567772327313	3.4024698430598	0.836261061532606	0.967158162378108	19:11766999-11784078:+	ZNF441	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 441 [Source:HGNC Symbol%3BAcc:HGNC:20875]
ENSG00000139826	6.99	7.66	5.39	6.74	7.43	6.47	-0.0410133103426859	2.80218437200879	0.836370045247078	0.967194090893608	13:108218378-108234255:+	ABHD13	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity	NA	abhydrolase domain containing 13 [Source:HGNC Symbol%3BAcc:HGNC:20293]
ENSG00000149480	43.91	44.35	44.07	43.71	44.24	44.25	0.0128806896406819	6.46850767589369	0.836470565021765	0.967220225767599	11:62593213-62601840:-	MTA2	33;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006306,biological_process DNA methylation;GO:0006333,biological_process chromatin assembly or disassembly;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0010762,biological_process regulation of fibroblast migration;GO:0016020,cellular_component membrane;GO:0016575,biological_process histone deacetylation;GO:0016581,cellular_component NuRD complex;GO:0031492,molecular_function nucleosomal DNA binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043234,cellular_component protein complex;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	metastasis associated 1 family member 2 [Source:HGNC Symbol%3BAcc:HGNC:7411]
ENSG00000145439	9.14	7.23	12.58	10.06	9.26	10.82	-0.0336959263676702	3.05143148686453	0.836711806073748	0.967409058196109	4:168863769-169010275:-	CBR4	19;GO:0003955,molecular_function NAD(P)H dehydrogenase (quinone) activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0008753,molecular_function NADPH dehydrogenase (quinone) activity;GO:0016491,molecular_function oxidoreductase activity;GO:0044597,biological_process daunorubicin metabolic process;GO:0044598,biological_process doxorubicin metabolic process;GO:0046949,biological_process fatty-acyl-CoA biosynthetic process;GO:0047025,molecular_function 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity;GO:0048038,molecular_function quinone binding;GO:0051289,biological_process protein homotetramerization;GO:0051290,biological_process protein heterotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0070402,molecular_function NADPH binding;GO:1990204,cellular_component oxidoreductase complex	CBR4; carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]; K11539	carbonyl reductase 4 [Source:HGNC Symbol%3BAcc:HGNC:25891]
ENSG00000198736	19.05	18.52	18.81	18.09	18.53	21.13	-0.0238010728982115	3.77832937732468	0.836826989227188	0.967452120450506	16:1938209-1943326:-	MSRB1	20;GO:0002376,biological_process immune system process;GO:0003779,molecular_function actin binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006979,biological_process response to oxidative stress;GO:0008270,molecular_function zinc ion binding;GO:0015629,cellular_component actin cytoskeleton;GO:0016491,molecular_function oxidoreductase activity;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0030041,biological_process actin filament polymerization;GO:0030091,biological_process protein repair;GO:0033743,molecular_function peptide-methionine (R)-S-oxide reductase activity;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070191,molecular_function methionine-R-sulfoxide reductase activity	NA	methionine sulfoxide reductase B1 [Source:HGNC Symbol%3BAcc:HGNC:14133]
ENSG00000141448	5.06	5.09	4.78	5.12	5.18	5.04	-0.0289070164367615	3.19534397557685	0.837028478022953	0.967588364370594	18:22169442-22202528:+	GATA6	68;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0001889,biological_process liver development;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003309,biological_process type B pancreatic cell differentiation;GO:0003310,biological_process pancreatic A cell differentiation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006644,biological_process phospholipid metabolic process;GO:0007493,biological_process endodermal cell fate determination;GO:0007596,biological_process blood coagulation;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008584,biological_process male gonad development;GO:0010468,biological_process regulation of gene expression;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0019901,molecular_function protein kinase binding;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0030855,biological_process epithelial cell differentiation;GO:0031016,biological_process pancreas development;GO:0031965,cellular_component nuclear membrane;GO:0032911,biological_process negative regulation of transforming growth factor beta1 production;GO:0032912,biological_process negative regulation of transforming growth factor beta2 production;GO:0035239,biological_process tube morphogenesis;GO:0035987,biological_process endodermal cell differentiation;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043627,biological_process response to estrogen;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044267,biological_process cellular protein metabolic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048645,biological_process organ formation;GO:0048738,biological_process cardiac muscle tissue development;GO:0051145,biological_process smooth muscle cell differentiation;GO:0051891,biological_process positive regulation of cardioblast differentiation;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060430,biological_process lung saccule development;GO:0060486,biological_process Clara cell differentiation;GO:0060510,biological_process Type II pneumocyte differentiation;GO:0060575,biological_process intestinal epithelial cell differentiation;GO:0060947,biological_process cardiac vascular smooth muscle cell differentiation;GO:0070848,biological_process response to growth factor;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071371,biological_process cellular response to gonadotropin stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0071773,biological_process cellular response to BMP stimulus;GO:0110024,Biological_Process positive regulation of cardiac muscle myoblast proliferation	GATA4; GATA-binding protein 4; K09183	GATA binding protein 6 [Source:HGNC Symbol%3BAcc:HGNC:4174]
ENSG00000240891	9.03	9.06	9.22	7.90	11.26	9.06	-0.0341279176268661	3.3927024122615	0.837378050231199	0.967588364370594	3:111674675-111846447:+	PLCXD2	7;GO:0004871,molecular_function signal transducer activity;GO:0005634,cellular_component nucleus;GO:0006629,biological_process lipid metabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity	NA	phosphatidylinositol specific phospholipase C X domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26462]
ENSG00000141040	1.73	1.26	1.00	1.41	1.20	1.60	-0.0605421507498462	1.71845355910779	0.837507389731337	0.967588364370594	17:16551386-16569206:-	ZNF287	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042035,biological_process regulation of cytokine biosynthetic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 287 [Source:HGNC Symbol%3BAcc:HGNC:13502]
ENSG00000147166	0.60	0.82	0.98	0.78	1.44	0.40	-0.107681299077181	0.0375979222033251	0.837543611247803	0.967588364370594	X:71301733-71305371:+	ITGB1BP2	9;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0007165,biological_process signal transduction;GO:0007517,biological_process muscle organ development;GO:0008270,molecular_function zinc ion binding;GO:0017124,molecular_function SH3 domain binding;GO:0030018,cellular_component Z disc;GO:0046872,molecular_function metal ion binding	NA	integrin subunit beta 1 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6154]
ENSG00000203896	1.92	2.10	2.70	1.65	2.46	2.43	0.0529408418146272	1.18087444517685	0.837632897719127	0.967588364370594	20:63736282-63739103:+	LIME1	10;GO:0000390,biological_process spliceosomal complex disassembly;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050853,biological_process B cell receptor signaling pathway;GO:0071008,cellular_component U2-type post-mRNA release spliceosomal complex	NA	Lck interacting transmembrane adaptor 1 [Source:HGNC Symbol%3BAcc:HGNC:26016]
ENSG00000147642	1.81	2.08	1.99	1.85	1.76	2.14	0.0340000216801207	2.05510275479141	0.837727013887182	0.967588364370594	8:109573977-109691791:-	SYBU	16;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0008017,molecular_function microtubule binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017075,molecular_function syntaxin-1 binding;GO:0019894,molecular_function kinesin binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0061178,biological_process regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0097433,cellular_component dense body	NA	syntabulin [Source:HGNC Symbol%3BAcc:HGNC:26011]
ENSG00000197579	12.75	14.05	11.67	12.25	14.71	12.31	-0.021320242589148	5.34785465813239	0.837786333460467	0.967588364370594	9:32540543-32552553:-	TOPORS	41;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0000922,cellular_component spindle pole;GO:0000930,cellular_component gamma-tubulin complex;GO:0003677,molecular_function DNA binding;GO:0003823,molecular_function antigen binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005814,cellular_component centriole;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010842,biological_process retina layer formation;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0030496,cellular_component midbody;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0034504,biological_process protein localization to nucleus;GO:0035845,biological_process photoreceptor cell outer segment organization;GO:0036064,cellular_component ciliary basal body;GO:0042127,biological_process regulation of cell proliferation;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044547,molecular_function DNA topoisomerase binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046548,biological_process retinal rod cell development;GO:0046549,biological_process retinal cone cell development;GO:0046872,molecular_function metal ion binding;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0051457,biological_process maintenance of protein location in nucleus;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination	NA	TOP1 binding arginine/serine rich protein [Source:HGNC Symbol%3BAcc:HGNC:21653]
ENSG00000073578	115.57	117.19	109.29	112.94	120.86	114.11	-0.0130906063054015	7.93523463500174	0.837910318187594	0.967588364370594	5:218240-256700:+	SDHA	21;GO:0000104,molecular_function succinate dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005749,cellular_component mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0006099,biological_process tricarboxylic acid cycle;GO:0006105,biological_process succinate metabolic process;GO:0006121,biological_process mitochondrial electron transport, succinate to ubiquinone;GO:0007399,biological_process nervous system development;GO:0008177,molecular_function succinate dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0009061,biological_process anaerobic respiration;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0022900,biological_process electron transport chain;GO:0022904,biological_process respiratory electron transport chain;GO:0043209,cellular_component myelin sheath;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]; K00234	succinate dehydrogenase complex flavoprotein subunit A [Source:HGNC Symbol%3BAcc:HGNC:10680]
ENSG00000112110	125.43	139.28	122.40	133.66	125.70	126.44	0.0133006135357474	6.12280024349691	0.837935063710223	0.967588364370594	6:159789811-159798436:+	MRPL18	16;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0006810,biological_process transport;GO:0008097,molecular_function 5S rRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035928,biological_process rRNA import into mitochondrion;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L18, MRPL18, rplR; large subunit ribosomal protein L18; K02881	mitochondrial ribosomal protein L18 [Source:HGNC Symbol%3BAcc:HGNC:14477]
ENSG00000166526	24.77	24.55	22.13	24.82	23.38	24.61	-0.0175998046142532	5.14011504338223	0.837973892571586	0.967588364370594	7:100064032-100082548:-	ZNF3	14;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0030154,biological_process cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0045321,biological_process leukocyte activation;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 3 [Source:HGNC Symbol%3BAcc:HGNC:13089]
ENSG00000160783	4.87	6.93	5.25	5.34	6.97	5.36	-0.056335252735848	2.29197621347181	0.838002682885196	0.967588364370594	1:156212992-156240042:+	PMF1	21;GO:0000444,cellular_component MIS12/MIND type complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005694,cellular_component chromosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043522,molecular_function leucine zipper domain binding;GO:0051301,biological_process cell division	NA	polyamine modulated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:9112]
ENSG00000170802	6.34	5.32	7.46	6.08	8.21	5.60	-0.034544967570245	3.10331443015621	0.838145046053889	0.967588364370594	2:48314636-48379294:+	FOXN2	11;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	forkhead box N2 [Source:HGNC Symbol%3BAcc:HGNC:5281]
ENSG00000099800	122.91	148.21	136.87	133.72	144.77	137.18	-0.0203614088775851	5.29393370601596	0.83830668833965	0.967588364370594	19:2425623-2427894:-	TIMM13	14;GO:0001650,cellular_component fibrillar center;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0007605,biological_process sensory perception of sound;GO:0008270,molecular_function zinc ion binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0042719,cellular_component mitochondrial intermembrane space protein transporter complex;GO:0045039,biological_process protein import into mitochondrial inner membrane;GO:0046872,molecular_function metal ion binding;GO:0072321,biological_process chaperone-mediated protein transport	NA	translocase of inner mitochondrial membrane 13 [Source:HGNC Symbol%3BAcc:HGNC:11816]
ENSG00000118046	45.74	46.10	50.99	50.44	47.40	47.67	-0.0140838816722173	6.09309948412215	0.838393175787598	0.967588364370594	19:1177557-1228435:+	STK11	65;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001558,biological_process regulation of cell growth;GO:0001894,biological_process tissue homeostasis;GO:0001944,biological_process vasculature development;GO:0002039,molecular_function p53 binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007283,biological_process spermatogenesis;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010212,biological_process response to ionizing radiation;GO:0010508,biological_process positive regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0030010,biological_process establishment of cell polarity;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030154,biological_process cell differentiation;GO:0030275,molecular_function LRR domain binding;GO:0030295,molecular_function protein kinase activator activity;GO:0030308,biological_process negative regulation of cell growth;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0032147,biological_process activation of protein kinase activity;GO:0036398,cellular_component TCR signalosome;GO:0036399,biological_process TCR signalosome assembly;GO:0042593,biological_process glucose homeostasis;GO:0043276,biological_process anoikis;GO:0045059,biological_process positive thymic T cell selection;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051055,biological_process negative regulation of lipid biosynthetic process;GO:0051645,biological_process Golgi localization;GO:0051896,biological_process regulation of protein kinase B signaling;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060770,biological_process negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0070062,cellular_component extracellular exosome;GO:0071493,biological_process cellular response to UV-B;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:0097484,biological_process dendrite extension;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904262,biological_process negative regulation of TORC1 signaling	STK11, LKB1; serine/threonine-protein kinase 11 [EC:2.7.11.1]; K07298	serine/threonine kinase 11 [Source:HGNC Symbol%3BAcc:HGNC:11389]
ENSG00000128626	46.40	61.17	58.13	50.64	59.90	53.33	0.0219229246433623	4.51287565465225	0.838515979338839	0.967588364370594	19:38930547-38933162:+	MRPS12	15;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0015935,cellular_component small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12; K02950	mitochondrial ribosomal protein S12 [Source:HGNC Symbol%3BAcc:HGNC:10380]
ENSG00000139370	33.37	31.30	32.44	34.65	31.33	31.00	0.0160485954633493	5.81257533548393	0.838619311572633	0.967588364370594	12:128793190-128823983:-	SLC15A4	16;GO:0005215,molecular_function transporter activity;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006857,biological_process oligopeptide transport;GO:0015031,biological_process protein transport;GO:0015293,molecular_function symporter activity;GO:0015333,molecular_function peptide:proton symporter activity;GO:0015833,biological_process peptide transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 15 member 4 [Source:HGNC Symbol%3BAcc:HGNC:23090]
ENSG00000180758	2.04	2.85	1.68	2.23	1.89	2.17	0.0441183333084731	1.19036088914246	0.838630639316029	0.967588364370594	1:9100304-9129170:-	GPR157	16;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0042995,cellular_component cell projection;GO:0048512,biological_process circadian behavior;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0060019,biological_process radial glial cell differentiation;GO:0060170,cellular_component ciliary membrane	NA	G protein-coupled receptor 157 [Source:HGNC Symbol%3BAcc:HGNC:23687]
ENSG00000110315	47.25	44.80	50.71	48.82	45.68	47.94	0.0184260301808101	5.07338390834495	0.83867196251813	0.967588364370594	11:10511677-10541230:-	RNF141	6;GO:0003677,molecular_function DNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0046872,molecular_function metal ion binding;GO:0051865,biological_process protein autoubiquitination	NA	ring finger protein 141 [Source:HGNC Symbol%3BAcc:HGNC:21159]
ENSG00000100351	1.35	0.68	1.11	0.83	1.07	1.14	0.0975629853104845	0.250946251976036	0.838685267707612	0.967588364370594	22:39901081-39973721:+	GRAP2	21;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007265,biological_process Ras protein signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0009967,biological_process positive regulation of signal transduction;GO:0016477,biological_process cell migration;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031295,biological_process T cell costimulation;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0045087,biological_process innate immune response;GO:0050852,biological_process T cell receptor signaling pathway	GRAP2, GADS; GRB2-related adaptor protein 2; K07366	GRB2-related adaptor protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4563]
ENSG00000167595	9.21	10.63	9.55	10.86	9.84	9.35	-0.0269654328626509	3.9652046494702	0.838703926320591	0.967588364370594	19:35758142-35771028:+	PROSER3	NA	NA	proline and serine rich 3 [Source:HGNC Symbol%3BAcc:HGNC:25204]
ENSG00000075413	40.20	37.36	39.91	42.80	36.47	40.45	-0.0145891535152513	6.63765386431597	0.838732002236465	0.967588364370594	14:103385391-103503831:+	MARK3	17;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030010,biological_process establishment of cell polarity;GO:0035331,biological_process negative regulation of hippo signaling;GO:0070062,cellular_component extracellular exosome	NA	microtubule affinity regulating kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:6897]
ENSG00000132005	5.26	6.06	6.52	6.65	6.05	4.95	0.0254483572701622	4.15097146569777	0.838779425324991	0.967588364370594	19:13961537-14007039:-	RFX1	11;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006955,biological_process immune response;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	regulatory factor X1 [Source:HGNC Symbol%3BAcc:HGNC:9982]
ENSG00000164062	46.93	53.39	45.86	47.69	51.20	46.82	0.0143348854499988	6.77583446706276	0.838992996901235	0.967588364370594	3:49674001-49683963:+	APEH	17;GO:0003723,molecular_function RNA binding;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006415,biological_process translational termination;GO:0006508,biological_process proteolysis;GO:0008236,molecular_function serine-type peptidase activity;GO:0008242,molecular_function omega peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0031965,cellular_component nuclear membrane;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation;GO:0050435,biological_process beta-amyloid metabolic process;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	acylaminoacyl-peptide hydrolase [Source:HGNC Symbol%3BAcc:HGNC:586]
ENSG00000010539	10.31	9.68	10.06	11.82	9.22	9.91	-0.0273540998116154	3.61102829354647	0.839077624128492	0.967588364370594	16:3222324-3236221:-	ZNF200	7;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 200 [Source:HGNC Symbol%3BAcc:HGNC:12993]
ENSG00000105738	9.62	10.02	8.93	9.99	8.92	10.19	-0.0175360201193605	5.73410875286228	0.839219216119146	0.967588364370594	19:37907227-38208372:+	SIPA1L3	15;GO:0001654,biological_process eye development;GO:0001725,cellular_component stress fiber;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003382,biological_process epithelial cell morphogenesis;GO:0005096,molecular_function GTPase activator activity;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007010,biological_process cytoskeleton organization;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045177,cellular_component apical part of cell;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0061689,cellular_component tricellular tight junction;GO:0090162,biological_process establishment of epithelial cell polarity	NA	signal induced proliferation associated 1 like 3 [Source:HGNC Symbol%3BAcc:HGNC:23801]
ENSG00000189057	5.93	8.29	6.32	6.29	7.72	7.03	-0.0341830222686878	3.93793430601821	0.839234032333724	0.967588364370594	11:59107184-59127410:+	FAM111B	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 111 member B [Source:HGNC Symbol%3BAcc:HGNC:24200]
ENSG00000065491	13.43	12.81	11.13	11.42	13.02	13.83	-0.0250697540192602	4.26753774052724	0.839400909980803	0.967588364370594	6:37257771-37332970:+	TBC1D22B	9;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0071889,molecular_function 14-3-3 protein binding;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 22B [Source:HGNC Symbol%3BAcc:HGNC:21602]
ENSG00000204427	18.59	21.09	21.06	20.00	21.95	19.97	-0.0185139845735554	5.23145015982138	0.839496559986586	0.967588364370594	6:31686948-31703444:-	ABHD16A	7;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0047372,molecular_function acylglycerol lipase activity;GO:0052651,biological_process monoacylglycerol catabolic process;GO:1905344,biological_process prostaglandin catabolic process	NA	abhydrolase domain containing 16A [Source:HGNC Symbol%3BAcc:HGNC:13921]
ENSG00000179387	24.50	29.70	23.70	26.48	28.97	24.15	-0.0263906781263405	4.54281830326543	0.839562885984226	0.967588364370594	4:140524157-140553770:+	ELMOD2	5;GO:0005096,molecular_function GTPase activator activity;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0050688,biological_process regulation of defense response to virus;GO:0051607,biological_process defense response to virus	NA	ELMO domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28111]
ENSG00000149196	72.72	61.18	66.84	65.43	63.91	70.98	0.0188949198104483	5.43172920976284	0.839590354234796	0.967588364370594	11:86302210-86345931:+	HIKESHI	15;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007030,biological_process Golgi organization;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0030324,biological_process lung development;GO:0030544,molecular_function Hsp70 protein binding;GO:0034605,biological_process cellular response to heat;GO:0070062,cellular_component extracellular exosome;GO:1900034,biological_process regulation of cellular response to heat	NA	Hikeshi%2C heat shock protein nuclear import factor [Source:HGNC Symbol%3BAcc:HGNC:26938]
ENSG00000221874	7.88	5.74	8.53	7.93	7.05	8.15	-0.0323965298728047	2.45312305627608	0.839649253962439	0.967588364370594	19:52928474-52962823:-	ZNF816-ZNF321P	3;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	ZNF816-ZNF321P readthrough [Source:HGNC Symbol%3BAcc:HGNC:38879]
ENSG00000164919	599.53	535.59	508.99	565.70	551.80	557.23	-0.0142000475367587	6.96254027918808	0.839712542631865	0.967588364370594	8:99873199-99894062:-	COX6C	8;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	COX6C; cytochrome c oxidase subunit 6c; K02268	cytochrome c oxidase subunit 6C [Source:HGNC Symbol%3BAcc:HGNC:2285]
ENSG00000144306	16.90	16.56	16.84	16.46	16.73	16.93	0.0178368272423138	4.49062022883276	0.839896799299387	0.967588364370594	2:174395729-174429575:+	SCRN3	3;GO:0006508,biological_process proteolysis;GO:0006887,biological_process exocytosis;GO:0016805,molecular_function dipeptidase activity	NA	secernin 3 [Source:HGNC Symbol%3BAcc:HGNC:30382]
ENSG00000142546	35.20	42.53	37.92	38.57	39.71	39.47	-0.0207497669207623	5.21922904798441	0.839934534033072	0.967588364370594	19:49555710-49590262:-	NOSIP	14;GO:0000139,cellular_component Golgi membrane;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0043086,biological_process negative regulation of catalytic activity;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051001,biological_process negative regulation of nitric-oxide synthase activity;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	nitric oxide synthase interacting protein [Source:HGNC Symbol%3BAcc:HGNC:17946]
ENSG00000103196	3.35	2.79	3.10	3.64	2.21	3.19	0.047186237702684	2.28488001544249	0.839962427187985	0.967588364370594	16:84819983-84920768:+	CRISPLD2	12;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0008201,molecular_function heparin binding;GO:0030133,cellular_component transport vesicle;GO:0030198,biological_process extracellular matrix organization;GO:0030324,biological_process lung development;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0060325,biological_process face morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	cysteine rich secretory protein LCCL domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25248]
ENSG00000197558	0.04	0.06	0.09	0.07	0.04	0.08	-0.111822919581869	0.189003521171464	0.839964505667545	0.967588364370594	7:149776041-149833979:+	SSPO	4;GO:0007399,biological_process nervous system development;GO:0010466,biological_process negative regulation of peptidase activity;GO:0030154,biological_process cell differentiation;GO:0030414,molecular_function peptidase inhibitor activity	NA	SCO-spondin [Source:HGNC Symbol%3BAcc:HGNC:21998]
ENSG00000213020	8.70	9.14	7.04	8.33	9.04	7.23	0.0249066259565905	4.22024507456867	0.840063871720229	0.967588364370594	19:52702812-52735073:-	ZNF611	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 611 [Source:HGNC Symbol%3BAcc:HGNC:28766]
ENSG00000120899	1.26	1.32	1.51	1.46	1.30	1.23	0.0503416184206197	2.08119712753921	0.840089871091916	0.967588364370594	8:27311481-27459391:+	PTK2B	146;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000302,biological_process response to reactive oxygen species;GO:0001525,biological_process angiogenesis;GO:0001556,biological_process oocyte maturation;GO:0001666,biological_process response to hypoxia;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0002040,biological_process sprouting angiogenesis;GO:0002250,biological_process adaptive immune response;GO:0002315,biological_process marginal zone B cell differentiation;GO:0002376,biological_process immune system process;GO:0002688,biological_process regulation of leukocyte chemotaxis;GO:0004672,molecular_function protein kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0004972,molecular_function NMDA glutamate receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006461,biological_process protein complex assembly;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0006968,biological_process cellular defense response;GO:0006970,biological_process response to osmotic stress;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007172,biological_process signal complex assembly;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008360,biological_process regulation of cell shape;GO:0009612,biological_process response to mechanical stimulus;GO:0009725,biological_process response to hormone;GO:0009749,biological_process response to glucose;GO:0010226,biological_process response to lithium ion;GO:0010243,biological_process response to organonitrogen compound;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010656,biological_process negative regulation of muscle cell apoptotic process;GO:0010752,biological_process regulation of cGMP-mediated signaling;GO:0010758,biological_process regulation of macrophage chemotaxis;GO:0010976,biological_process positive regulation of neuron projection development;GO:0014009,biological_process glial cell proliferation;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017146,cellular_component NMDA selective glutamate receptor complex;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030155,biological_process regulation of cell adhesion;GO:0030279,biological_process negative regulation of ossification;GO:0030307,biological_process positive regulation of cell growth;GO:0030334,biological_process regulation of cell migration;GO:0030335,biological_process positive regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030500,biological_process regulation of bone mineralization;GO:0030502,biological_process negative regulation of bone mineralization;GO:0030826,biological_process regulation of cGMP biosynthetic process;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031175,biological_process neuron projection development;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032403,molecular_function protein complex binding;GO:0032960,biological_process regulation of inositol trisphosphate biosynthetic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0035235,biological_process ionotropic glutamate receptor signaling pathway;GO:0035902,biological_process response to immobilization stress;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042976,biological_process activation of Janus kinase activity;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043149,biological_process stress fiber assembly;GO:0043197,cellular_component dendritic spine;GO:0043267,biological_process negative regulation of potassium ion transport;GO:0043423,molecular_function 3-phosphoinositide-dependent protein kinase binding;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043534,biological_process blood vessel endothelial cell migration;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0044297,cellular_component cell body;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0045428,biological_process regulation of nitric oxide biosynthetic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045453,biological_process bone resorption;GO:0045471,biological_process response to ethanol;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045727,biological_process positive regulation of translation;GO:0045765,biological_process regulation of angiogenesis;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046777,biological_process protein autophosphorylation;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048041,biological_process focal adhesion assembly;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050848,biological_process regulation of calcium-mediated signaling;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0051591,biological_process response to cAMP;GO:0051592,biological_process response to calcium ion;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0060291,biological_process long-term synaptic potentiation;GO:0060292,biological_process long term synaptic depression;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071300,biological_process cellular response to retinoic acid;GO:0071498,biological_process cellular response to fluid shear stress;GO:0090630,biological_process activation of GTPase activity;GO:0097440,cellular_component apical dendrite;GO:2000058,biological_process regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000249,biological_process regulation of actin cytoskeleton reorganization;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000538,biological_process positive regulation of B cell chemotaxis;GO:2000573,biological_process positive regulation of DNA biosynthetic process	PTK2B, FAK2; focal adhesion kinase 2 [EC:2.7.10.2]; K05871	protein tyrosine kinase 2 beta [Source:HGNC Symbol%3BAcc:HGNC:9612]
ENSG00000152582	3.30	3.62	3.37	3.17	3.71	3.34	0.0171291225918237	4.74537596800884	0.84014408950656	0.967588364370594	5:35617843-35814611:+	SPEF2	1;GO:0003676,molecular_function nucleic acid binding	NA	sperm flagellar 2 [Source:HGNC Symbol%3BAcc:HGNC:26293]
ENSG00000101367	68.52	78.81	70.58	70.12	79.52	67.26	0.0156688862945584	5.86702601400639	0.84020174596823	0.967588364370594	20:32819892-32850405:+	MAPRE1	34;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0008017,molecular_function microtubule binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030335,biological_process positive regulation of cell migration;GO:0030981,cellular_component cortical microtubule cytoskeleton;GO:0031115,biological_process negative regulation of microtubule polymerization;GO:0031253,cellular_component cell projection membrane;GO:0035371,cellular_component microtubule plus-end;GO:0035372,biological_process protein localization to microtubule;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0045296,molecular_function cadherin binding;GO:0051010,molecular_function microtubule plus-end binding;GO:0051301,biological_process cell division;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1903033,biological_process positive regulation of microtubule plus-end binding;GO:1904527,biological_process negative regulation of microtubule binding	NA	microtubule associated protein RP/EB family member 1 [Source:HGNC Symbol%3BAcc:HGNC:6890]
ENSG00000107362	13.12	16.14	15.25	14.25	16.65	12.99	0.0272255813759006	3.72136187411244	0.840250499530064	0.967588364370594	9:71862451-71910931:-	ABHD17B	3;GO:0005576,cellular_component extracellular region;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity	NA	abhydrolase domain containing 17B [Source:HGNC Symbol%3BAcc:HGNC:24278]
ENSG00000117691	62.82	61.86	57.20	59.93	63.35	57.92	0.0168537972932107	4.97160671168514	0.840420275295429	0.967588364370594	1:212432886-212446379:+	NENF	8;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0008083,molecular_function growth factor activity;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0032099,biological_process negative regulation of appetite;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0046872,molecular_function metal ion binding	NA	neudesin neurotrophic factor [Source:HGNC Symbol%3BAcc:HGNC:30384]
ENSG00000256525	14.80	11.10	16.04	14.15	13.29	14.26	0.0299975971733687	4.36102973591213	0.840561817660396	0.967588364370594	17:64477784-64497036:-	POLG2	22;GO:0000262,cellular_component mitochondrial chromosome;GO:0001701,biological_process in utero embryonic development;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0004820,molecular_function glycine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0007005,biological_process mitochondrion organization;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0022904,biological_process respiratory electron transport chain;GO:0032042,biological_process mitochondrial DNA metabolic process;GO:0042645,cellular_component mitochondrial nucleoid;GO:0042802,molecular_function identical protein binding;GO:0070062,cellular_component extracellular exosome;GO:0070150,biological_process mitochondrial glycyl-tRNA aminoacylation;GO:0070584,biological_process mitochondrion morphogenesis;GO:0071897,biological_process DNA biosynthetic process	NA	DNA polymerase gamma 2%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:9180]
ENSG00000159882	3.79	3.50	3.10	2.84	3.81	4.10	-0.0412723377052898	2.42112025459852	0.840562088760839	0.967588364370594	19:44002947-44013926:+	ZNF230	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 230 [Source:HGNC Symbol%3BAcc:HGNC:13024]
ENSG00000159884	18.53	18.73	15.67	16.36	17.42	18.61	0.0210256230142256	3.97527489333304	0.84063477076997	0.967588364370594	9:35658289-35661511:+	CCDC107	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	coiled-coil domain containing 107 [Source:HGNC Symbol%3BAcc:HGNC:28465]
ENSG00000131981	397.48	346.71	411.37	409.07	348.68	421.17	-0.0165439940230007	8.37485906532864	0.840774940480507	0.967588364370594	14:55124109-55145413:+	LGALS3	43;GO:0001772,cellular_component immunological synapse;GO:0002376,biological_process immune system process;GO:0002548,biological_process monocyte chemotaxis;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005886,cellular_component plasma membrane;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0019863,molecular_function IgE binding;GO:0030154,biological_process cell differentiation;GO:0030246,molecular_function carbohydrate binding;GO:0030593,biological_process neutrophil chemotaxis;GO:0030667,cellular_component secretory granule membrane;GO:0030855,biological_process epithelial cell differentiation;GO:0031012,cellular_component extracellular matrix;GO:0042056,molecular_function chemoattractant activity;GO:0042129,biological_process regulation of T cell proliferation;GO:0043236,molecular_function laminin binding;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0045637,biological_process regulation of myeloid cell differentiation;GO:0045806,biological_process negative regulation of endocytosis;GO:0048245,biological_process eosinophil chemotaxis;GO:0048246,biological_process macrophage chemotaxis;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0050918,biological_process positive chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:0070232,biological_process regulation of T cell apoptotic process;GO:0071674,biological_process mononuclear cell migration;GO:0071677,biological_process positive regulation of mononuclear cell migration;GO:0090280,biological_process positive regulation of calcium ion import;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000521,biological_process negative regulation of immunological synapse formation;GO:2001189,biological_process negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	galectin 3 [Source:HGNC Symbol%3BAcc:HGNC:6563]
ENSG00000103415	37.55	35.98	34.91	35.38	35.38	37.45	0.0147420681497663	5.40226853350986	0.840830759587814	0.967588364370594	16:4474689-4510347:+	HMOX2	20;GO:0001666,biological_process response to hypoxia;GO:0004392,molecular_function heme oxygenase (decyclizing) activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006788,biological_process heme oxidation;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006979,biological_process response to oxidative stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0020037,molecular_function heme binding;GO:0035579,cellular_component specific granule membrane;GO:0042167,biological_process heme catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0046872,molecular_function metal ion binding;GO:0055072,biological_process iron ion homeostasis;GO:0055114,biological_process oxidation-reduction process	HMOX1; heme oxygenase 1 [EC:1.14.14.18]; K00510	heme oxygenase 2 [Source:HGNC Symbol%3BAcc:HGNC:5014]
ENSG00000117523	41.99	42.62	44.73	43.59	44.19	43.71	-0.01182100369854	8.52377421083975	0.84094419008335	0.967588364370594	1:171485550-171593511:+	PRRC2C	4;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003723,molecular_function RNA binding;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane	NA	proline rich coiled-coil 2C [Source:HGNC Symbol%3BAcc:HGNC:24903]
ENSG00000060749	11.39	11.87	10.68	10.53	12.54	10.74	0.0157925684458209	5.96828588452333	0.841083799055248	0.967588364370594	11:32893177-32993316:+	QSER1	NA	NA	glutamine and serine rich 1 [Source:HGNC Symbol%3BAcc:HGNC:26154]
ENSG00000173166	9.03	8.32	9.16	10.52	7.57	9.06	-0.0208248390830191	5.14358924443538	0.841173393505622	0.967588364370594	2:203394344-203535410:-	RAPH1	13;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0031252,cellular_component cell leading edge;GO:0042995,cellular_component cell projection;GO:0048675,biological_process axon extension	NA	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [Source:HGNC Symbol%3BAcc:HGNC:14436]
ENSG00000197892	6.18	5.78	5.38	5.70	6.23	5.77	-0.0166630940995228	5.04470537224176	0.841336272861939	0.967588364370594	8:29067278-29263124:-	KIF13B	25;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005902,cellular_component microvillus;GO:0006605,biological_process protein targeting;GO:0007018,biological_process microtubule-based movement;GO:0007165,biological_process signal transduction;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity;GO:0019901,molecular_function protein kinase binding;GO:0030424,cellular_component axon;GO:0030705,biological_process cytoskeleton-dependent intracellular transport;GO:0033270,cellular_component paranode region of axon;GO:0042110,biological_process T cell activation;GO:0042995,cellular_component cell projection;GO:0050770,biological_process regulation of axonogenesis;GO:0071889,molecular_function 14-3-3 protein binding;GO:0072383,biological_process plus-end-directed vesicle transport along microtubule	NA	kinesin family member 13B [Source:HGNC Symbol%3BAcc:HGNC:14405]
ENSG00000158793	38.28	35.72	35.46	36.36	34.51	40.81	-0.0168537264302515	5.27665792518487	0.84139923424278	0.967588364370594	1:161118085-161125445:+	NIT1	9;GO:0000257,molecular_function nitrilase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006807,biological_process nitrogen compound metabolic process;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0016810,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0070062,cellular_component extracellular exosome	NA	nitrilase 1 [Source:HGNC Symbol%3BAcc:HGNC:7828]
ENSG00000188158	7.07	6.46	6.93	7.10	6.78	7.01	-0.013739837760476	5.11940928390669	0.841496028417916	0.967588364370594	X:17375419-17735994:+	NHS	13;GO:0002088,biological_process lens development in camera-type eye;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0005925,cellular_component focal adhesion;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016604,cellular_component nuclear body;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0042995,cellular_component cell projection	NA	NHS actin remodeling regulator [Source:HGNC Symbol%3BAcc:HGNC:7820]
ENSG00000172765	9.01	10.24	10.10	10.62	9.44	9.90	-0.0228122460544574	4.28644346079069	0.841597788348225	0.967588364370594	3:129647791-129893576:-	TMCC1	12;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007029,biological_process endoplasmic reticulum organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization	NA	transmembrane and coiled-coil domain family 1 [Source:HGNC Symbol%3BAcc:HGNC:29116]
ENSG00000148019	9.94	12.31	9.48	10.68	10.85	9.87	0.0184581327187013	4.51955675636252	0.841677757485968	0.967588364370594	9:78236061-78279690:+	CEP78	14;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0044782,biological_process cilium organization;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 78 [Source:HGNC Symbol%3BAcc:HGNC:25740]
ENSG00000122971	15.14	15.49	15.14	14.53	14.55	16.35	0.0192384897030665	4.39761943243068	0.841797499864049	0.967588364370594	12:120725734-120740008:+	ACADS	14;GO:0003995,molecular_function acyl-CoA dehydrogenase activity;GO:0004085,molecular_function butyryl-CoA dehydrogenase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	ACADS, bcd; butyryl-CoA dehydrogenase [EC:1.3.8.1]; K00248	acyl-CoA dehydrogenase%2C C-2 to C-3 short chain [Source:HGNC Symbol%3BAcc:HGNC:90]
ENSG00000104221	3.93	5.11	4.26	4.56	4.51	3.92	0.0331465907801506	2.56983098712772	0.841966303709564	0.967588364370594	8:37843267-37849904:-	BRF2	10;GO:0001007,molecular_function transcription factor activity, RNA polymerase III transcription factor binding;GO:0001032,molecular_function RNA polymerase III type 3 promoter DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0034599,biological_process cellular response to oxidative stress;GO:0046872,molecular_function metal ion binding;GO:0070897,biological_process DNA-templated transcriptional preinitiation complex assembly	NA	BRF2%2C RNA polymerase III transcription initiation factor subunit [Source:HGNC Symbol%3BAcc:HGNC:17298]
ENSG00000152291	86.93	90.83	91.59	89.87	93.19	90.85	-0.0128458456377306	7.06169940509066	0.841982162208747	0.967588364370594	2:85318019-85328425:-	TGOLN2	17;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006895,biological_process Golgi to endosome transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030133,cellular_component transport vesicle;GO:0030140,cellular_component trans-Golgi network transport vesicle;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0061024,biological_process membrane organization	NA	trans-golgi network protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15450]
ENSG00000180938	2.71	2.89	3.80	3.44	2.77	3.59	-0.0456872750874824	2.39334628189533	0.842087189021355	0.967588364370594	8:124973297-124979389:+	ZNF572	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 572 [Source:HGNC Symbol%3BAcc:HGNC:26758]
ENSG00000141580	82.95	75.22	83.55	84.99	78.75	82.52	-0.0128050878688503	6.4110587914243	0.842151801939977	0.967588364370594	17:82614561-82648553:-	WDR45B	10;GO:0000422,biological_process mitophagy;GO:0005829,cellular_component cytosol;GO:0006497,biological_process protein lipidation;GO:0006914,biological_process autophagy;GO:0019898,cellular_component extrinsic component of membrane;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0044804,biological_process nucleophagy;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding	NA	WD repeat domain 45B [Source:HGNC Symbol%3BAcc:HGNC:25072]
ENSG00000196391	0.69	0.69	1.54	1.42	0.84	0.51	0.109121416814394	0.685862099173289	0.842155125594528	0.967588364370594	15:90352244-90369146:+	ZNF774	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 774 [Source:HGNC Symbol%3BAcc:HGNC:33108]
ENSG00000179044	0.48	0.36	0.50	0.22	0.48	0.57	0.10194777929772	0.251238011368442	0.842283850885166	0.967588364370594	16:67184365-67190204:-	EXOC3L1	9;GO:0000145,cellular_component exocyst;GO:0000149,molecular_function SNARE binding;GO:0003674,molecular_function molecular_function;GO:0006887,biological_process exocytosis;GO:0030072,biological_process peptide hormone secretion;GO:0030133,cellular_component transport vesicle;GO:0030141,cellular_component secretory granule;GO:0031410,cellular_component cytoplasmic vesicle;GO:0051601,biological_process exocyst localization	NA	exocyst complex component 3 like 1 [Source:HGNC Symbol%3BAcc:HGNC:27540]
ENSG00000116698	19.79	19.25	19.43	19.79	19.27	19.39	0.0130165800026579	6.29084020546293	0.842327891320203	0.967588364370594	1:183472215-183598246:+	SMG7	17;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0004540,molecular_function ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006406,biological_process mRNA export from nucleus;GO:0007004,biological_process telomere maintenance via telomerase;GO:0035303,biological_process regulation of dephosphorylation;GO:0042162,molecular_function telomeric DNA binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043487,biological_process regulation of RNA stability;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070034,molecular_function telomerase RNA binding;GO:0090501,biological_process RNA phosphodiester bond hydrolysis	SMG7, EST1C; protein SMG7; K14409	SMG7%2C nonsense mediated mRNA decay factor [Source:HGNC Symbol%3BAcc:HGNC:16792]
ENSG00000178074	10.52	8.69	9.88	9.92	10.11	9.92	-0.0203946686802711	3.53133332718291	0.842444312198261	0.967588364370594	2:199911255-199955935:+	C2orf69	1;GO:0005576,cellular_component extracellular region	NA	chromosome 2 open reading frame 69 [Source:HGNC Symbol%3BAcc:HGNC:26799]
ENSG00000148606	6.60	6.46	5.58	6.19	6.89	5.97	-0.0202940739545381	4.72374604691726	0.84257700437927	0.967588364370594	10:77969250-78029545:-	POLR3A	21;GO:0001056,molecular_function RNA polymerase III activity;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	RPC1, POLR3A; DNA-directed RNA polymerase III subunit RPC1 [EC:2.7.7.6]; K03018	RNA polymerase III subunit A [Source:HGNC Symbol%3BAcc:HGNC:30074]
ENSG00000105993	140.64	141.65	144.40	152.21	129.88	143.92	0.0139535211507524	7.36118400339536	0.842624377677059	0.967588364370594	7:157335380-157417439:+	DNAJB6	27;GO:0001671,molecular_function ATPase activator activity;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0016020,cellular_component membrane;GO:0030018,cellular_component Z disc;GO:0030036,biological_process actin cytoskeleton organization;GO:0030198,biological_process extracellular matrix organization;GO:0031072,molecular_function heat shock protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0032880,biological_process regulation of protein localization;GO:0034504,biological_process protein localization to nucleus;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045109,biological_process intermediate filament organization;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0060710,biological_process chorio-allantoic fusion;GO:0060715,biological_process syncytiotrophoblast cell differentiation involved in labyrinthine layer development;GO:0060717,biological_process chorion development;GO:0090084,biological_process negative regulation of inclusion body assembly;GO:1900034,biological_process regulation of cellular response to heat	NA	DnaJ heat shock protein family (Hsp40) member B6 [Source:HGNC Symbol%3BAcc:HGNC:14888]
ENSG00000101882	19.29	17.35	18.21	17.32	17.48	19.82	0.0200848786045546	4.51843687862322	0.842635988987798	0.967588364370594	X:119920671-119943772:-	NKAP	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007219,biological_process Notch signaling pathway;GO:0019827,biological_process stem cell population maintenance;GO:0030097,biological_process hemopoiesis;GO:0030851,biological_process granulocyte differentiation;GO:0031490,molecular_function chromatin DNA binding;GO:0033077,biological_process T cell differentiation in thymus;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046638,biological_process positive regulation of alpha-beta T cell differentiation;GO:0071425,biological_process hematopoietic stem cell proliferation;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	NFKB activating protein [Source:HGNC Symbol%3BAcc:HGNC:29873]
ENSG00000130305	19.70	17.28	20.64	20.09	18.85	20.01	-0.015131529492185	4.79407084528619	0.842816602322741	0.967588364370594	7:73302516-73308867:-	NSUN5	10;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0070475,biological_process rRNA base methylation	NA	NOP2/Sun RNA methyltransferase family member 5 [Source:HGNC Symbol%3BAcc:HGNC:16385]
ENSG00000183010	140.87	126.91	135.63	140.84	133.66	136.05	-0.0122943104430552	7.24898715020289	0.842868684238706	0.967588364370594	17:81932383-81942412:-	PYCR1	13;GO:0004735,molecular_function pyrroline-5-carboxylate reductase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006561,biological_process proline biosynthetic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0042802,molecular_function identical protein binding;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055114,biological_process oxidation-reduction process;GO:0055129,biological_process L-proline biosynthetic process;GO:1903206,biological_process negative regulation of hydrogen peroxide-induced cell death	proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]; K00286	pyrroline-5-carboxylate reductase 1 [Source:HGNC Symbol%3BAcc:HGNC:9721]
ENSG00000144840	22.05	25.11	25.16	23.90	24.10	25.82	-0.023796653720438	4.12014428803205	0.842995168167392	0.967588364370594	3:120686680-120742993:-	RABL3	4;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction	NA	RAB%2C member of RAS oncogene family like 3 [Source:HGNC Symbol%3BAcc:HGNC:18072]
ENSG00000138107	43.78	47.36	40.82	41.33	47.89	42.17	0.0153410166593259	5.64061983993501	0.843042166340516	0.967588364370594	10:102461880-102502711:-	ACTR1A	25;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0002177,cellular_component manchette;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005869,cellular_component dynactin complex;GO:0005875,cellular_component microtubule associated complex;GO:0005938,cellular_component cell cortex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007283,biological_process spermatogenesis;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030137,cellular_component COPI-coated vesicle;GO:0043209,cellular_component myelin sheath;GO:0070062,cellular_component extracellular exosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0099738,cellular_component cell cortex region	NA	ARP1 actin related protein 1 homolog A [Source:HGNC Symbol%3BAcc:HGNC:167]
ENSG00000135407	1.87	1.56	1.75	1.75	1.65	1.70	0.0451158441486665	2.19233479071916	0.843096025676788	0.967588364370594	12:57797375-57818704:-	AVIL	14;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0007399,biological_process nervous system development;GO:0010975,biological_process regulation of neuron projection development;GO:0010976,biological_process positive regulation of neuron projection development;GO:0015629,cellular_component actin cytoskeleton;GO:0030424,cellular_component axon;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0051015,molecular_function actin filament binding;GO:0051693,biological_process actin filament capping;GO:0060271,biological_process cilium morphogenesis	NA	advillin [Source:HGNC Symbol%3BAcc:HGNC:14188]
ENSG00000166035	3.56	4.64	4.40	4.38	3.59	4.99	-0.041447058991644	2.80382473639898	0.843148760705727	0.967588364370594	15:58410568-58569843:+	LIPC	28;GO:0004620,molecular_function phospholipase activity;GO:0004806,molecular_function triglyceride lipase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006629,biological_process lipid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0008201,molecular_function heparin binding;GO:0008203,biological_process cholesterol metabolic process;GO:0016042,biological_process lipid catabolic process;GO:0016298,molecular_function lipase activity;GO:0016787,molecular_function hydrolase activity;GO:0019433,biological_process triglyceride catabolic process;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030301,biological_process cholesterol transport;GO:0034185,molecular_function apolipoprotein binding;GO:0034364,cellular_component high-density lipoprotein particle;GO:0034372,biological_process very-low-density lipoprotein particle remodeling;GO:0034373,biological_process intermediate-density lipoprotein particle remodeling;GO:0034374,biological_process low-density lipoprotein particle remodeling;GO:0034375,biological_process high-density lipoprotein particle remodeling;GO:0034382,biological_process chylomicron remnant clearance;GO:0034638,biological_process phosphatidylcholine catabolic process;GO:0042632,biological_process cholesterol homeostasis;GO:0043691,biological_process reverse cholesterol transport;GO:0051004,biological_process regulation of lipoprotein lipase activity;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0070328,biological_process triglyceride homeostasis	lip, TGL2; triacylglycerol lipase [EC:3.1.1.3]; K01046	lipase C%2C hepatic type [Source:HGNC Symbol%3BAcc:HGNC:6619]
ENSG00000143512	2.18	2.11	1.83	2.07	1.96	1.97	0.0383174015294716	2.18132922100687	0.843363432910421	0.967588364370594	1:222522257-222548103:-	HHIPL2	3;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region	NA	HHIP like 2 [Source:HGNC Symbol%3BAcc:HGNC:25842]
ENSG00000126351	13.81	10.94	13.66	13.23	12.35	12.69	0.0266590966163261	4.36167943684096	0.843375886561675	0.967588364370594	17:40058289-40093867:+	THRA	52;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001502,biological_process cartilage condensation;GO:0001503,biological_process ossification;GO:0002153,molecular_function steroid receptor RNA activator RNA binding;GO:0002155,biological_process regulation of thyroid hormone mediated signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003727,molecular_function single-stranded RNA binding;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004887,molecular_function thyroid hormone receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0007611,biological_process learning or memory;GO:0008016,biological_process regulation of heart contraction;GO:0008050,biological_process female courtship behavior;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0009409,biological_process response to cold;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0009887,biological_process organ morphogenesis;GO:0010831,biological_process positive regulation of myotube differentiation;GO:0017025,molecular_function TBP-class protein binding;GO:0017055,biological_process negative regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0019904,molecular_function protein domain specific binding;GO:0030218,biological_process erythrocyte differentiation;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0030878,biological_process thyroid gland development;GO:0031490,molecular_function chromatin DNA binding;GO:0032403,molecular_function protein complex binding;GO:0033032,biological_process regulation of myeloid cell apoptotic process;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045925,biological_process positive regulation of female receptivity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050994,biological_process regulation of lipid catabolic process;GO:0060509,biological_process Type I pneumocyte differentiation;GO:0070324,molecular_function thyroid hormone binding;GO:2000143,biological_process negative regulation of DNA-templated transcription, initiation	THRA, NR1A1; thyroid hormone receptor alpha; K05547	thyroid hormone receptor%2C alpha [Source:HGNC Symbol%3BAcc:HGNC:11796]
ENSG00000140650	38.30	40.25	35.50	40.87	35.51	37.06	0.0160006284305354	5.01622402986154	0.843406046670174	0.967588364370594	16:8788822-8849331:+	PMM2	13;GO:0004615,molecular_function phosphomannomutase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006013,biological_process mannose metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0009298,biological_process GDP-mannose biosynthetic process;GO:0016853,molecular_function isomerase activity;GO:0043025,cellular_component neuronal cell body;GO:0045047,biological_process protein targeting to ER;GO:0070062,cellular_component extracellular exosome	manB; phosphomannomutase [EC:5.4.2.8]; K01840	phosphomannomutase 2 [Source:HGNC Symbol%3BAcc:HGNC:9115]
ENSG00000188690	38.49	35.55	34.45	35.56	35.04	37.62	0.0162106433609191	5.18237488306919	0.843478696718063	0.967588364370594	10:125784979-125823248:-	UROS	13;GO:0004852,molecular_function uroporphyrinogen-III synthase activity;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006780,biological_process uroporphyrinogen III biosynthetic process;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0016829,molecular_function lyase activity;GO:0033014,biological_process tetrapyrrole biosynthetic process;GO:0046677,biological_process response to antibiotic;GO:0048037,molecular_function cofactor binding;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0071418,biological_process cellular response to amine stimulus	hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75]; K01719	uroporphyrinogen III synthase [Source:HGNC Symbol%3BAcc:HGNC:12592]
ENSG00000185432	1.93	1.57	0.90	1.13	1.86	1.15	0.102109213791003	0.252016006043032	0.843678857686519	0.967588364370594	12:50923471-50932517:+	METTL7A	12;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005811,cellular_component lipid particle;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen	NA	methyltransferase like 7A [Source:HGNC Symbol%3BAcc:HGNC:24550]
ENSG00000204516	3.38	3.99	3.65	3.58	3.56	4.22	-0.046022571348524	2.14879177332002	0.843763965464145	0.967588364370594	6:31494880-31511124:+	MICB	18;GO:0001913,biological_process T cell mediated cytotoxicity;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002429,biological_process immune response-activating cell surface receptor signaling pathway;GO:0005886,cellular_component plasma membrane;GO:0006979,biological_process response to oxidative stress;GO:0009408,biological_process response to heat;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019835,biological_process cytolysis;GO:0032526,biological_process response to retinoic acid;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0046629,biological_process gamma-delta T cell activation;GO:0046703,molecular_function natural killer cell lectin-like receptor binding;GO:0050689,biological_process negative regulation of defense response to virus by host;GO:0050776,biological_process regulation of immune response	MIC; MHC class I-related protein; K07985	MHC class I polypeptide-related sequence B [Source:HGNC Symbol%3BAcc:HGNC:7091]
ENSG00000138760	150.75	150.77	154.76	151.73	145.65	158.85	0.0119585298919541	8.0438255326481	0.843768848145073	0.967588364370594	4:76158732-76234536:-	SCARB2	22;GO:0001618,molecular_function virus receptor activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006622,biological_process protein targeting to lysosome;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0019899,molecular_function enzyme binding;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031902,cellular_component late endosome membrane;GO:0043202,cellular_component lysosomal lumen;GO:0046718,biological_process viral entry into host cell;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:1904978,biological_process regulation of endosome organization;GO:1905123,biological_process regulation of glucosylceramidase activity;GO:1905671,biological_process regulation of lysosome organization	SCARB2, LIMP2, CD36L2; lysosome membrane protein 2; K12384	scavenger receptor class B member 2 [Source:HGNC Symbol%3BAcc:HGNC:1665]
ENSG00000270170	18.79	14.48	18.83	14.87	15.32	20.83	0.0509488603503438	2.40583778686507	0.843788354506945	0.967588364370594	3:196942622-196943540:+	NCBP2-AS2	NA	NA	NCBP2 antisense RNA 2 (head to head) [Source:HGNC Symbol%3BAcc:HGNC:25121]
ENSG00000067248	6.42	6.59	6.60	7.22	7.22	5.62	-0.0203894766538884	4.77403732388651	0.843871770741288	0.967588364370594	5:55256244-55307722:-	DHX29	19;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0003743,molecular_function translation initiation factor activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0006396,biological_process RNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0016282,cellular_component eukaryotic 43S preinitiation complex;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0043024,molecular_function ribosomal small subunit binding;GO:0045296,molecular_function cadherin binding;GO:0045948,biological_process positive regulation of translational initiation	NA	DExH-box helicase 29 [Source:HGNC Symbol%3BAcc:HGNC:15815]
ENSG00000184205	8.14	6.94	8.76	8.45	8.23	7.06	0.0278231815096296	4.06956526311974	0.843902761183419	0.967588364370594	X:53082366-53088540:+	TSPYL2	17;GO:0000182,molecular_function rDNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006334,biological_process nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008156,biological_process negative regulation of DNA replication;GO:0009966,biological_process regulation of signal transduction;GO:0016569,biological_process covalent chromatin modification;GO:0030308,biological_process negative regulation of cell growth;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0045786,biological_process negative regulation of cell cycle;GO:0045859,biological_process regulation of protein kinase activity	NA	TSPY like 2 [Source:HGNC Symbol%3BAcc:HGNC:24358]
ENSG00000142686	9.87	9.46	9.86	8.61	9.83	10.34	0.0332660895117379	2.76553494585706	0.843906197650822	0.967588364370594	1:35713874-35719472:-	C1orf216	1;GO:0005515,molecular_function protein binding	NA	chromosome 1 open reading frame 216 [Source:HGNC Symbol%3BAcc:HGNC:26800]
ENSG00000165704	64.36	71.60	62.68	66.97	72.60	57.95	0.0175676828758103	5.43561659468626	0.844025775945531	0.967588364370594	X:134460152-134520513:+	HPRT1	37;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001975,biological_process response to amphetamine;GO:0004422,molecular_function hypoxanthine phosphoribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006164,biological_process purine nucleotide biosynthetic process;GO:0006166,biological_process purine ribonucleoside salvage;GO:0006168,biological_process adenine salvage;GO:0006178,biological_process guanine salvage;GO:0007625,biological_process grooming behavior;GO:0007626,biological_process locomotory behavior;GO:0009116,biological_process nucleoside metabolic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019835,biological_process cytolysis;GO:0021756,biological_process striatum development;GO:0021895,biological_process cerebral cortex neuron differentiation;GO:0021954,biological_process central nervous system neuron development;GO:0032264,biological_process IMP salvage;GO:0042417,biological_process dopamine metabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043101,biological_process purine-containing compound salvage;GO:0043103,biological_process hypoxanthine salvage;GO:0045964,biological_process positive regulation of dopamine metabolic process;GO:0046038,biological_process GMP catabolic process;GO:0046040,biological_process IMP metabolic process;GO:0046083,biological_process adenine metabolic process;GO:0046100,biological_process hypoxanthine metabolic process;GO:0046651,biological_process lymphocyte proliferation;GO:0046872,molecular_function metal ion binding;GO:0048813,biological_process dendrite morphogenesis;GO:0051289,biological_process protein homotetramerization;GO:0052657,molecular_function guanine phosphoribosyltransferase activity;GO:0070062,cellular_component extracellular exosome	hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]; K00760	hypoxanthine phosphoribosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:5157]
ENSG00000147439	14.06	11.21	11.88	11.36	12.57	14.31	-0.0234830277908789	3.57090471123579	0.84408854937275	0.967588364370594	8:22620417-22669148:-	BIN3	16;GO:0000910,biological_process cytokinesis;GO:0000917,biological_process barrier septum assembly;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0007015,biological_process actin filament organization;GO:0007049,biological_process cell cycle;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0008104,biological_process protein localization;GO:0009826,biological_process unidimensional cell growth;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0014839,biological_process myoblast migration involved in skeletal muscle regeneration;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0048741,biological_process skeletal muscle fiber development;GO:0051301,biological_process cell division	NA	bridging integrator 3 [Source:HGNC Symbol%3BAcc:HGNC:1054]
ENSG00000198355	17.91	19.35	18.44	18.53	19.39	17.40	0.018801586128758	4.18792620921229	0.844105988629983	0.967588364370594	22:49960512-49964080:+	PIM3	17;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046777,biological_process protein autophosphorylation;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus	NA	Pim-3 proto-oncogene%2C serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:19310]
ENSG00000166839	1.48	1.60	1.28	1.70	1.50	1.34	-0.0568637335536303	1.39127991511352	0.844118309655396	0.967588364370594	15:64911901-64958700:+	ANKDD1A	1;GO:0007165,biological_process signal transduction	NA	ankyrin repeat and death domain containing 1A [Source:HGNC Symbol%3BAcc:HGNC:28002]
ENSG00000131475	82.47	92.36	81.71	83.12	89.05	83.46	0.013019469053152	5.74285290687198	0.844197337793311	0.967588364370594	17:42773435-42779599:+	VPS25	22;GO:0000814,cellular_component ESCRT II complex;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0036258,biological_process multivesicular body assembly;GO:0042803,molecular_function protein homodimerization activity;GO:0043328,biological_process protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0047485,molecular_function protein N-terminus binding;GO:0070062,cellular_component extracellular exosome	VPS25, EAP20; ESCRT-II complex subunit VPS25; K12189	vacuolar protein sorting 25 homolog [Source:HGNC Symbol%3BAcc:HGNC:28122]
ENSG00000173145	10.89	12.94	13.22	12.57	11.95	12.31	0.0164958464265123	4.89129610279379	0.844216254635772	0.967588364370594	10:94333225-94362959:-	NOC3L	7;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0016607,cellular_component nuclear speck;GO:0045444,biological_process fat cell differentiation	NA	NOC3 like DNA replication regulator [Source:HGNC Symbol%3BAcc:HGNC:24034]
ENSG00000149948	6.42	6.27	8.46	7.66	6.42	6.75	0.0423868751423925	2.51362031111705	0.844274040487582	0.967588364370594	12:65824130-65966295:+	HMGA2	78;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000228,cellular_component nuclear chromosome;GO:0000785,cellular_component chromatin;GO:0000975,molecular_function regulatory region DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0002062,biological_process chondrocyte differentiation;GO:0003131,biological_process mesodermal-endodermal cell signaling;GO:0003677,molecular_function DNA binding;GO:0003680,molecular_function AT DNA binding;GO:0003906,molecular_function DNA-(apurinic or apyrimidinic site) lyase activity;GO:0004677,molecular_function DNA-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006284,biological_process base-excision repair;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007049,biological_process cell cycle;GO:0007095,biological_process mitotic G2 DNA damage checkpoint;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0008301,molecular_function DNA binding, bending;GO:0009615,biological_process response to virus;GO:0010564,biological_process regulation of cell cycle process;GO:0010628,biological_process positive regulation of gene expression;GO:0019899,molecular_function enzyme binding;GO:0030261,biological_process chromosome condensation;GO:0031052,biological_process chromosome breakage;GO:0031492,molecular_function nucleosomal DNA binding;GO:0031507,biological_process heterochromatin assembly;GO:0032993,cellular_component protein-DNA complex;GO:0033144,biological_process negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0035497,molecular_function cAMP response element binding;GO:0035500,molecular_function MH2 domain binding;GO:0035501,molecular_function MH1 domain binding;GO:0035978,biological_process histone H2A-S139 phosphorylation;GO:0035985,cellular_component senescence-associated heterochromatin focus;GO:0035986,biological_process senescence-associated heterochromatin focus assembly;GO:0035987,biological_process endodermal cell differentiation;GO:0035988,biological_process chondrocyte proliferation;GO:0040008,biological_process regulation of growth;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043392,biological_process negative regulation of DNA binding;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0045444,biological_process fat cell differentiation;GO:0045869,biological_process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046426,biological_process negative regulation of JAK-STAT cascade;GO:0048333,biological_process mesodermal cell differentiation;GO:0048762,biological_process mesenchymal cell differentiation;GO:0048863,biological_process stem cell differentiation;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051301,biological_process cell division;GO:0051575,molecular_function 5'-deoxyribose-5-phosphate lyase activity;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0071141,cellular_component SMAD protein complex;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0090402,biological_process oncogene-induced cell senescence;GO:2000036,biological_process regulation of stem cell population maintenance;GO:2000648,biological_process positive regulation of stem cell proliferation;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding;GO:2000685,biological_process positive regulation of cellular response to X-ray;GO:2000774,biological_process positive regulation of cellular senescence;GO:2001022,biological_process positive regulation of response to DNA damage stimulus;GO:2001033,biological_process negative regulation of double-strand break repair via nonhomologous end joining;GO:2001038,biological_process regulation of cellular response to drug	HMGA2; high mobility group AT-hook protein 2; K09283	high mobility group AT-hook 2 [Source:HGNC Symbol%3BAcc:HGNC:5009]
ENSG00000101544	12.27	11.35	12.20	12.56	11.76	12.20	-0.013104343956718	5.42532919860122	0.844313165334758	0.967588364370594	18:80109030-80147523:+	ADNP2	14;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030182,biological_process neuron differentiation;GO:0030307,biological_process positive regulation of cell growth;GO:0034599,biological_process cellular response to oxidative stress;GO:0046872,molecular_function metal ion binding;GO:0060548,biological_process negative regulation of cell death;GO:0071300,biological_process cellular response to retinoic acid	NA	ADNP homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:23803]
ENSG00000141582	16.36	15.09	18.80	17.75	14.41	17.80	0.0228313104445341	4.92516767915725	0.844557167074265	0.967588364370594	17:79833155-79839429:-	CBX4	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003727,molecular_function single-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016874,molecular_function ligase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0019899,molecular_function enzyme binding;GO:0031519,cellular_component PcG protein complex;GO:0032183,molecular_function SUMO binding;GO:0035064,molecular_function methylated histone binding;GO:0035102,cellular_component PRC1 complex;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051219,molecular_function phosphoprotein binding	NA	chromobox 4 [Source:HGNC Symbol%3BAcc:HGNC:1554]
ENSG00000110583	16.88	16.40	18.49	16.24	18.68	16.46	0.027189503822053	3.82755892104759	0.844560993086348	0.967588364370594	11:63938958-63957328:+	NAA40	12;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006474,biological_process N-terminal protein amino acid acetylation;GO:0006629,biological_process lipid metabolic process;GO:0008080,molecular_function N-acetyltransferase activity;GO:0010485,molecular_function H4 histone acetyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0043998,molecular_function H2A histone acetyltransferase activity;GO:1990189,molecular_function peptide-serine-N-acetyltransferase activity	NA	N(alpha)-acetyltransferase 40%2C NatD catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:25845]
ENSG00000100393	18.50	17.68	18.28	17.66	19.30	17.47	0.0136295287735168	7.04097667178149	0.844576366280434	0.967588364370594	22:41091785-41180079:+	EP300	92;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001666,biological_process response to hypoxia;GO:0001756,biological_process somitogenesis;GO:0002039,molecular_function p53 binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0004468,molecular_function lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006473,biological_process protein acetylation;GO:0006475,biological_process internal protein amino acid acetylation;GO:0006915,biological_process apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006990,biological_process positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response;GO:0007049,biological_process cell cycle;GO:0007219,biological_process Notch signaling pathway;GO:0007399,biological_process nervous system development;GO:0007507,biological_process heart development;GO:0007519,biological_process skeletal muscle tissue development;GO:0007623,biological_process circadian rhythm;GO:0008013,molecular_function beta-catenin binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0009887,biological_process organ morphogenesis;GO:0010506,biological_process regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0010742,biological_process macrophage derived foam cell differentiation;GO:0016032,biological_process viral process;GO:0016407,molecular_function acetyltransferase activity;GO:0016573,biological_process histone acetylation;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018076,biological_process N-terminal peptidyl-lysine acetylation;GO:0018393,biological_process internal peptidyl-lysine acetylation;GO:0030183,biological_process B cell differentiation;GO:0030220,biological_process platelet formation;GO:0030324,biological_process lung development;GO:0031490,molecular_function chromatin DNA binding;GO:0031648,biological_process protein destabilization;GO:0032092,biological_process positive regulation of protein binding;GO:0032481,biological_process positive regulation of type I interferon production;GO:0033613,molecular_function activating transcription factor binding;GO:0034212,molecular_function peptide N-acetyltransferase activity;GO:0034644,biological_process cellular response to UV;GO:0035257,molecular_function nuclear hormone receptor binding;GO:0035855,biological_process megakaryocyte development;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043234,cellular_component protein complex;GO:0043627,biological_process response to estrogen;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0043967,biological_process histone H4 acetylation;GO:0043969,biological_process histone H2B acetylation;GO:0045444,biological_process fat cell differentiation;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0050681,molecular_function androgen receptor binding;GO:0050821,biological_process protein stabilization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051726,biological_process regulation of cell cycle;GO:0060765,biological_process regulation of androgen receptor signaling pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061733,molecular_function peptide-lysine-N-acetyltransferase activity;GO:0090043,biological_process regulation of tubulin deacetylation;GO:0097157,molecular_function pre-mRNA intronic binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904837,biological_process beta-catenin-TCF complex assembly	EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]; K04498	E1A binding protein p300 [Source:HGNC Symbol%3BAcc:HGNC:3373]
ENSG00000130177	39.38	34.63	40.05	38.68	36.58	38.71	0.016091578512673	6.14894658267487	0.844581975529372	0.967588364370594	13:114234886-114272723:+	CDC16	24;GO:0000278,biological_process mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0008283,biological_process cell proliferation;GO:0016567,biological_process protein ubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0070979,biological_process protein K11-linked ubiquitination	APC6, CDC16; anaphase-promoting complex subunit 6; K03353	cell division cycle 16 [Source:HGNC Symbol%3BAcc:HGNC:1720]
ENSG00000088035	11.55	11.87	12.55	12.34	12.16	12.25	-0.0193046919639903	4.2698641686216	0.844664374091859	0.967588364370594	1:63367589-63438562:+	ALG6	14;GO:0004583,molecular_function dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0006490,biological_process oligosaccharide-lipid intermediate biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0042281,molecular_function dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity;GO:0046527,molecular_function glucosyltransferase activity	ALG6; alpha-1,3-glucosyltransferase [EC:2.4.1.267]; K03848	ALG6%2C alpha-1%2C3-glucosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:23157]
ENSG00000103502	60.62	66.76	60.85	64.43	63.98	59.24	0.0132332383703034	5.8026399660737	0.844686828425029	0.967588364370594	16:29858356-29863736:-	CDIPT	19;GO:0000139,cellular_component Golgi membrane;GO:0003881,molecular_function CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016780,molecular_function phosphotransferase activity, for other substituted phosphate groups;GO:0019992,molecular_function diacylglycerol binding;GO:0030145,molecular_function manganese ion binding;GO:0030246,molecular_function carbohydrate binding;GO:0043178,molecular_function alcohol binding;GO:0046341,biological_process CDP-diacylglycerol metabolic process	CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]; K00999	CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Source:HGNC Symbol%3BAcc:HGNC:1769]
ENSG00000187866	7.73	8.33	10.89	8.12	8.99	9.48	0.0335692791971845	3.16621778045056	0.844695945231944	0.967588364370594	9:68780033-68784608:+	FAM122A	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 122A [Source:HGNC Symbol%3BAcc:HGNC:23490]
ENSG00000108175	15.62	15.52	16.08	15.98	16.20	15.00	0.0141447678734492	5.87080071972286	0.84474837721016	0.967588364370594	10:79069034-79316528:+	ZMIZ1	20;GO:0001570,biological_process vasculogenesis;GO:0001701,biological_process in utero embryonic development;GO:0003007,biological_process heart morphogenesis;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007296,biological_process vitellogenesis;GO:0007569,biological_process cell aging;GO:0008270,molecular_function zinc ion binding;GO:0016607,cellular_component nuclear speck;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045582,biological_process positive regulation of T cell differentiation;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048589,biological_process developmental growth;GO:0048844,biological_process artery morphogenesis	NA	zinc finger MIZ-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:16493]
ENSG00000125434	2.47	4.43	2.86	3.05	3.09	3.26	0.0343509308283397	1.79779924597632	0.844817746962741	0.967588364370594	17:8287762-8295343:-	SLC25A35	8;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 35 [Source:HGNC Symbol%3BAcc:HGNC:31921]
ENSG00000221995	23.13	27.98	24.53	24.31	25.72	27.52	-0.0366304691427787	3.16000680795805	0.845249897758919	0.9678409973263	17:29073520-29078857:-	TIAF1	5;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0006915,biological_process apoptotic process;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0043066,biological_process negative regulation of apoptotic process	NA	TGFB1-induced anti-apoptotic factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11803]
ENSG00000182551	37.02	34.13	31.03	33.30	36.87	34.19	-0.0175922039101628	4.9094775738102	0.845337532767624	0.9678409973263	2:3497360-3519736:-	ADI1	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009086,biological_process methionine biosynthetic process;GO:0010309,molecular_function acireductone dioxygenase [iron(II)-requiring] activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0019509,biological_process L-methionine biosynthetic process from methylthioadenosine;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	mtnD, mtnZ, ADI1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [EC:1.13.11.53 1.13.11.54]; K08967	acireductone dioxygenase 1 [Source:HGNC Symbol%3BAcc:HGNC:30576]
ENSG00000126603	21.34	22.25	21.44	19.81	23.88	21.07	0.0166246951955729	5.09389219037538	0.845508527413144	0.9678409973263	16:4314760-4339597:+	GLIS2	27;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001822,biological_process kidney development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0016607,cellular_component nuclear speck;GO:0030154,biological_process cell differentiation;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060994,biological_process regulation of transcription from RNA polymerase II promoter involved in kidney development;GO:0061005,biological_process cell differentiation involved in kidney development;GO:0097730,cellular_component non-motile cilium;GO:1900182,biological_process positive regulation of protein localization to nucleus	NA	GLIS family zinc finger 2 [Source:HGNC Symbol%3BAcc:HGNC:29450]
ENSG00000242028	54.18	52.02	54.97	61.41	49.35	54.30	-0.0207768908347291	4.43698944579359	0.845550810515342	0.9678409973263	15:43796141-43803043:+	HYPK	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0015630,cellular_component microtubule cytoskeleton;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0047485,molecular_function protein N-terminus binding;GO:0050821,biological_process protein stabilization	NA	huntingtin interacting protein K [Source:HGNC Symbol%3BAcc:HGNC:18418]
ENSG00000168672	24.53	22.09	24.14	21.58	25.44	25.48	-0.0192164412926269	4.48617655330693	0.845763699032643	0.9678409973263	8:126552441-126558393:-	FAM84B	3;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane	NA	family with sequence similarity 84 member B [Source:HGNC Symbol%3BAcc:HGNC:24166]
ENSG00000122729	70.04	72.17	65.57	68.70	74.42	68.24	-0.013426935633334	7.54329991915665	0.845952887133202	0.9678409973263	9:32384602-32454769:+	ACO1	24;GO:0003723,molecular_function RNA binding;GO:0003994,molecular_function aconitate hydratase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006099,biological_process tricarboxylic acid cycle;GO:0006101,biological_process citrate metabolic process;GO:0006417,biological_process regulation of translation;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008152,biological_process metabolic process;GO:0009791,biological_process post-embryonic development;GO:0010040,biological_process response to iron(II) ion;GO:0010468,biological_process regulation of gene expression;GO:0016829,molecular_function lyase activity;GO:0030350,molecular_function iron-responsive element binding;GO:0046872,molecular_function metal ion binding;GO:0050892,biological_process intestinal absorption;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051538,molecular_function 3 iron, 4 sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0070062,cellular_component extracellular exosome	ACO, acnA; aconitate hydratase [EC:4.2.1.3]; K01681	aconitase 1 [Source:HGNC Symbol%3BAcc:HGNC:117]
ENSG00000169155	5.85	4.84	6.15	4.76	5.85	6.02	0.039887857027866	3.00134918866869	0.846048158554439	0.9678409973263	9:126805005-126838210:+	ZBTB43	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 43 [Source:HGNC Symbol%3BAcc:HGNC:17908]
ENSG00000152683	12.21	10.67	9.43	11.67	10.34	11.14	-0.023444372504315	4.12665517699214	0.846050865565838	0.9678409973263	2:32165840-32224379:+	SLC30A6	15;GO:0000139,cellular_component Golgi membrane;GO:0005385,molecular_function zinc ion transmembrane transporter activity;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006829,biological_process zinc II ion transport;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0010043,biological_process response to zinc ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0061088,biological_process regulation of sequestering of zinc ion;GO:0071577,biological_process zinc II ion transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	solute carrier family 30 member 6 [Source:HGNC Symbol%3BAcc:HGNC:19305]
ENSG00000196850	6.89	7.13	5.65	7.47	6.65	6.17	-0.0387203460046718	2.6348452880763	0.846053681124319	0.9678409973263	12:110533244-110583320:-	PPTC7	6;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005739,cellular_component mitochondrion;GO:0006470,biological_process protein dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	PTC7 protein phosphatase homolog [Source:HGNC Symbol%3BAcc:HGNC:30695]
ENSG00000160813	34.62	27.83	27.73	29.20	25.98	34.28	0.0258705138286339	4.52067901706339	0.846061661756568	0.9678409973263	7:100435281-100436565:-	PPP1R35	3;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019902,molecular_function phosphatase binding	NA	protein phosphatase 1 regulatory subunit 35 [Source:HGNC Symbol%3BAcc:HGNC:28320]
ENSG00000108946	98.35	101.32	96.91	99.63	98.38	103.47	-0.0128142893068	6.99661989553407	0.846062498803336	0.9678409973263	17:68511779-68551319:+	PRKAR1A	37;GO:0000166,molecular_function nucleotide binding;GO:0001707,biological_process mesoderm formation;GO:0001772,cellular_component immunological synapse;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003091,biological_process renal water homeostasis;GO:0004862,molecular_function cAMP-dependent protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005952,cellular_component cAMP-dependent protein kinase complex;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007143,biological_process female meiotic division;GO:0007507,biological_process heart development;GO:0007596,biological_process blood coagulation;GO:0008603,molecular_function cAMP-dependent protein kinase regulator activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030552,molecular_function cAMP binding;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0031594,cellular_component neuromuscular junction;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034199,biological_process activation of protein kinase A activity;GO:0034236,molecular_function protein kinase A catalytic subunit binding;GO:0035556,biological_process intracellular signal transduction;GO:0043234,cellular_component protein complex;GO:0044853,cellular_component plasma membrane raft;GO:0045214,biological_process sarcomere organization;GO:0045835,biological_process negative regulation of meiotic nuclear division;GO:0045859,biological_process regulation of protein kinase activity;GO:0046007,biological_process negative regulation of activated T cell proliferation;GO:0060038,biological_process cardiac muscle cell proliferation;GO:0071377,biological_process cellular response to glucagon stimulus;GO:0097546,cellular_component ciliary base;GO:2000480,biological_process negative regulation of cAMP-dependent protein kinase activity	PRKAR; cAMP-dependent protein kinase regulator; K04739	protein kinase cAMP-dependent type I regulatory subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:9388]
ENSG00000254772	1552.10	1530.73	1524.07	1577.34	1496.08	1536.16	0.010903042087305	10.9768082474452	0.846148258657812	0.9678409973263	11:62559600-62574086:-	EEF1G	14;GO:0003746,molecular_function translation elongation factor activity;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0006749,biological_process glutathione metabolic process;GO:0009615,biological_process response to virus;GO:0016020,cellular_component membrane;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	EEF1G; elongation factor 1-gamma; K03233	eukaryotic translation elongation factor 1 gamma [Source:HGNC Symbol%3BAcc:HGNC:3213]
ENSG00000006125	98.64	95.23	95.38	99.52	99.62	94.83	-0.0114453276734477	8.24298453820531	0.846162648445184	0.9678409973263	17:35578045-35726409:+	AP2B1	40;GO:0003279,biological_process cardiac septum development;GO:0003281,biological_process ventricular septum development;GO:0005048,molecular_function signal sequence binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007018,biological_process microtubule-based movement;GO:0007507,biological_process heart development;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030117,cellular_component membrane coat;GO:0030118,cellular_component clathrin coat;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030276,molecular_function clathrin binding;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0032403,molecular_function protein complex binding;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035615,molecular_function clathrin adaptor activity;GO:0035904,biological_process aorta development;GO:0036020,cellular_component endolysosome membrane;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048268,biological_process clathrin coat assembly;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060976,biological_process coronary vasculature development;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0099590,biological_process neurotransmitter receptor internalization	AP2B1; AP-2 complex subunit beta-1; K11825	adaptor related protein complex 2 beta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:563]
ENSG00000139679	1.03	0.93	1.07	0.58	1.40	1.29	-0.0965256414190659	0.31158915946726	0.846287012714611	0.9678409973263	13:48389566-48444704:-	LPAR6	12;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051482,biological_process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;GO:0070915,molecular_function lysophosphatidic acid receptor activity	LPAR6, P2RY5; lysophosphatidic acid receptor 6; K04273	lysophosphatidic acid receptor 6 [Source:HGNC Symbol%3BAcc:HGNC:15520]
ENSG00000114544	18.45	17.55	17.49	18.92	18.27	16.15	0.0182883932017646	5.06306414847863	0.846295594632729	0.9678409973263	3:126006354-126101561:-	SLC41A3	8;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006812,biological_process cation transport;GO:0008324,molecular_function cation transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0098655,biological_process cation transmembrane transport	NA	solute carrier family 41 member 3 [Source:HGNC Symbol%3BAcc:HGNC:31046]
ENSG00000226479	23.07	25.12	24.81	23.75	25.21	25.45	-0.0191946912901153	4.69745802869947	0.846335089384136	0.9678409973263	2:120221277-120223408:-	TMEM185B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 185B [Source:HGNC Symbol%3BAcc:HGNC:18896]
ENSG00000182858	23.79	24.82	22.07	23.77	22.65	24.00	0.0134068700165244	5.23368476968205	0.846363814225166	0.9678409973263	22:49900228-49918458:-	ALG12	14;GO:0000009,molecular_function alpha-1,6-mannosyltransferase activity;GO:0000030,molecular_function mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006457,biological_process protein folding;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0052917,molecular_function dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity;GO:0097502,biological_process mannosylation	ALG12; alpha-1,6-mannosyltransferase [EC:2.4.1.260]; K03847	ALG12%2C alpha-1%2C6-mannosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:19358]
ENSG00000178031	0.47	0.28	0.45	0.47	0.38	0.42	-0.0400818984436448	1.3468529157127	0.846531913505432	0.967944053274036	9:17906562-18910950:+	ADAMTSL1	9;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0036066,biological_process protein O-linked fucosylation	NA	ADAMTS like 1 [Source:HGNC Symbol%3BAcc:HGNC:14632]
ENSG00000172053	76.20	74.58	75.76	76.76	75.22	74.63	0.0116536793572207	7.65241398640976	0.846777086031792	0.968135209442078	3:49095931-49105135:-	QARS	25;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004819,molecular_function glutamine-tRNA ligase activity;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006425,biological_process glutaminyl-tRNA aminoacylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007420,biological_process brain development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0019901,molecular_function protein kinase binding;GO:0032873,biological_process negative regulation of stress-activated MAPK cascade;GO:0043039,biological_process tRNA aminoacylation;GO:0043234,cellular_component protein complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:2001234,biological_process negative regulation of apoptotic signaling pathway	QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18]; K01886	glutaminyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:9751]
ENSG00000134548	3.45	4.39	2.11	3.66	3.27	2.42	0.0759843318113624	0.327505480472816	0.847152776904387	0.968475540588889	12:21526306-21537377:+	SPX	14;GO:0003084,biological_process positive regulation of systemic arterial blood pressure;GO:0005179,molecular_function hormone activity;GO:0005184,molecular_function neuropeptide hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0010459,biological_process negative regulation of heart rate;GO:0030133,cellular_component transport vesicle;GO:0031045,cellular_component dense core granule;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032099,biological_process negative regulation of appetite;GO:0035814,biological_process negative regulation of renal sodium excretion;GO:0044539,biological_process long-chain fatty acid import;GO:0051930,biological_process regulation of sensory perception of pain;GO:1904306,biological_process positive regulation of gastro-intestinal system smooth muscle contraction	NA	spexin hormone [Source:HGNC Symbol%3BAcc:HGNC:28139]
ENSG00000144559	8.30	8.32	9.49	10.77	7.78	8.31	-0.0265010993950004	3.90393765773969	0.847480467682204	0.968677481419402	3:11790441-11846919:-	TAMM41	11;GO:0004605,molecular_function phosphatidate cytidylyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006629,biological_process lipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0031314,cellular_component extrinsic component of mitochondrial inner membrane;GO:0032049,biological_process cardiolipin biosynthetic process	NA	TAM41 mitochondrial translocator assembly and maintenance homolog [Source:HGNC Symbol%3BAcc:HGNC:25187]
ENSG00000205581	549.09	550.65	561.05	533.01	567.76	587.82	-0.0121267141842794	7.78659377826259	0.847485494901692	0.968677481419402	21:39342314-39349647:-	HMGN1	18;GO:0000720,biological_process pyrimidine dimer repair by nucleotide-excision repair;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006325,biological_process chromatin organization;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0010224,biological_process response to UV-B;GO:0010225,biological_process response to UV-C;GO:0031492,molecular_function nucleosomal DNA binding;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0040034,biological_process regulation of development, heterochronic;GO:0048597,biological_process post-embryonic camera-type eye morphogenesis;GO:0050678,biological_process regulation of epithelial cell proliferation;GO:1901666,biological_process positive regulation of NAD+ ADP-ribosyltransferase activity	NA	high mobility group nucleosome binding domain 1 [Source:HGNC Symbol%3BAcc:HGNC:4984]
ENSG00000085185	3.16	3.43	2.86	3.17	3.27	2.93	0.0188955227793512	4.09324372329094	0.847588140095202	0.968705605653415	X:129981106-130058083:+	BCORL1	6;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification	NA	BCL6 corepressor like 1 [Source:HGNC Symbol%3BAcc:HGNC:25657]
ENSG00000196227	3.57	4.41	4.16	3.58	5.21	3.06	0.0421830599673575	2.23826117174707	0.847712898768591	0.968758995803215	20:59933763-59948680:+	FAM217B	2;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol	NA	family with sequence similarity 217 member B [Source:HGNC Symbol%3BAcc:HGNC:16170]
ENSG00000114784	84.17	85.42	77.51	93.42	80.99	77.79	-0.0191007188474277	4.82549914106294	0.848162330796061	0.968948089667876	3:40309683-40312424:+	EIF1B	7;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006446,biological_process regulation of translational initiation	EIF1, SUI1; translation initiation factor 1; K03113	eukaryotic translation initiation factor 1B [Source:HGNC Symbol%3BAcc:HGNC:30792]
ENSG00000213937	1.30	1.32	2.37	2.07	1.51	1.84	-0.0895539867368468	0.36925594509637	0.848237376077077	0.968948089667876	16:3012455-3014505:+	CLDN9	14;GO:0001618,molecular_function virus receptor activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016338,biological_process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030054,cellular_component cell junction;GO:0042802,molecular_function identical protein binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045216,biological_process cell-cell junction organization;GO:0046718,biological_process viral entry into host cell	CLDN; claudin; K06087	claudin 9 [Source:HGNC Symbol%3BAcc:HGNC:2051]
ENSG00000123415	8.39	7.48	6.54	8.17	7.47	7.42	-0.0277529246288181	3.13368047860003	0.848410146660268	0.968948089667876	12:54121276-54189008:-	SMUG1	14;GO:0000703,molecular_function oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity;GO:0003677,molecular_function DNA binding;GO:0004844,molecular_function uracil DNA N-glycosylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016787,molecular_function hydrolase activity;GO:0017065,molecular_function single-strand selective uracil DNA N-glycosylase activity;GO:0019104,molecular_function DNA N-glycosylase activity;GO:0045008,biological_process depyrimidination	SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]; K10800	single-strand-selective monofunctional uracil-DNA glycosylase 1 [Source:HGNC Symbol%3BAcc:HGNC:17148]
ENSG00000117868	48.59	49.98	51.30	51.03	49.21	52.12	-0.012234964085044	7.22443955693149	0.848465723789882	0.968948089667876	7:158730994-158830253:-	ESYT2	23;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0008429,molecular_function phosphatidylethanolamine binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031210,molecular_function phosphatidylcholine binding;GO:0031227,cellular_component intrinsic component of endoplasmic reticulum membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042802,molecular_function identical protein binding;GO:0044232,cellular_component organelle membrane contact site;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding	NA	extended synaptotagmin 2 [Source:HGNC Symbol%3BAcc:HGNC:22211]
ENSG00000213214	11.67	10.99	10.39	10.78	11.39	10.70	0.0216227734272059	4.01022173547477	0.848593481017751	0.968948089667876	7:144186082-144195655:-	ARHGEF35	NA	NA	Rho guanine nucleotide exchange factor 35 [Source:HGNC Symbol%3BAcc:HGNC:33846]
ENSG00000197728	261.62	322.15	274.78	270.62	318.10	265.78	0.0165431278830464	6.62323706820017	0.848610694227328	0.968948089667876	12:56041852-56044675:+	RPS26	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033119,biological_process negative regulation of RNA splicing;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	RP-S26e, RPS26; small subunit ribosomal protein S26e; K02976	ribosomal protein S26 [Source:HGNC Symbol%3BAcc:HGNC:10414]
ENSG00000065621	1.55	1.05	1.51	2.36	1.14	1.06	-0.10950503884494	0.281840978201047	0.848622680350478	0.968948089667876	10:104268872-104304945:+	GSTO2	19;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006749,biological_process glutathione metabolic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0008152,biological_process metabolic process;GO:0009407,biological_process toxin catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016740,molecular_function transferase activity;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0042802,molecular_function identical protein binding;GO:0045174,molecular_function glutathione dehydrogenase (ascorbate) activity;GO:0050610,molecular_function methylarsonate reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	glutathione S-transferase omega 2 [Source:HGNC Symbol%3BAcc:HGNC:23064]
ENSG00000138495	43.68	44.01	41.91	44.07	41.33	46.94	-0.0215705762114605	4.01665255230564	0.848669124778313	0.968948089667876	3:119654512-119677454:-	COX17	15;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006825,biological_process copper ion transport;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016531,molecular_function copper chaperone activity;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly;GO:0046872,molecular_function metal ion binding;GO:1903136,molecular_function cuprous ion binding;GO:1904960,biological_process positive regulation of cytochrome-c oxidase activity	COX17; cytochrome c oxidase assembly protein subunit 17; K02260	COX17%2C cytochrome c oxidase copper chaperone [Source:HGNC Symbol%3BAcc:HGNC:2264]
ENSG00000054690	3.26	2.64	2.66	2.58	2.93	3.32	-0.0270507033685012	3.59244858353199	0.848688536699713	0.968948089667876	14:67533300-67589612:+	PLEKHH1	1;GO:0005856,cellular_component cytoskeleton	NA	pleckstrin homology%2C MyTH4 and FERM domain containing H1 [Source:HGNC Symbol%3BAcc:HGNC:17733]
ENSG00000136731	31.44	33.14	30.89	30.02	34.11	31.21	0.0129009680302614	7.2433881681753	0.848723332740621	0.968948089667876	2:128091199-128195677:+	UGGT1	18;GO:0003980,molecular_function UDP-glucose:glycoprotein glucosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006486,biological_process protein glycosylation;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0043234,cellular_component protein complex;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0051082,molecular_function unfolded protein binding;GO:0051084,biological_process 'de novo' posttranslational protein folding;GO:0070062,cellular_component extracellular exosome;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:0097359,biological_process UDP-glucosylation;GO:1904380,biological_process endoplasmic reticulum mannose trimming	HUGT; UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-]; K11718	UDP-glucose glycoprotein glucosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:15663]
ENSG00000173041	9.48	10.98	9.66	10.93	9.56	10.26	-0.0261332721945527	4.12350747411018	0.848811301962884	0.968948089667876	7:64519883-64563106:-	ZNF680	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 680 [Source:HGNC Symbol%3BAcc:HGNC:26897]
ENSG00000124713	3.51	4.43	3.83	4.91	2.66	3.81	0.0474765440517321	1.82745538918603	0.848815075086481	0.968948089667876	6:42960757-42963880:+	GNMT	17;GO:0005515,molecular_function protein binding;GO:0005542,molecular_function folic acid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005977,biological_process glycogen metabolic process;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006464,biological_process cellular protein modification process;GO:0006555,biological_process methionine metabolic process;GO:0006730,biological_process one-carbon metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016594,molecular_function glycine binding;GO:0016740,molecular_function transferase activity;GO:0017174,molecular_function glycine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0046500,biological_process S-adenosylmethionine metabolic process;GO:0051289,biological_process protein homotetramerization	GNMT; glycine N-methyltransferase [EC:2.1.1.20]; K00552	glycine N-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:4415]
ENSG00000171206	24.87	21.10	27.16	25.05	23.86	25.86	-0.0146766460599465	5.35837226191519	0.849058755511749	0.96913288405972	10:102644495-102658407:+	TRIM8	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0010508,biological_process positive regulation of autophagy;GO:0016567,biological_process protein ubiquitination;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0019827,biological_process stem cell population maintenance;GO:0032897,biological_process negative regulation of viral transcription;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0046597,biological_process negative regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1902187,biological_process negative regulation of viral release from host cell	NA	tripartite motif containing 8 [Source:HGNC Symbol%3BAcc:HGNC:15579]
ENSG00000128272	581.30	560.69	599.15	609.93	581.82	577.64	-0.0113177177429169	9.26842230749851	0.849133106181706	0.96913288405972	22:39519694-39522685:+	ATF4	66;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006094,biological_process gluconeogenesis;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006520,biological_process cellular amino acid metabolic process;GO:0007214,biological_process gamma-aminobutyric acid signaling pathway;GO:0007623,biological_process circadian rhythm;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0032057,biological_process negative regulation of translational initiation in response to stress;GO:0032590,cellular_component dendrite membrane;GO:0032922,biological_process circadian regulation of gene expression;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034399,cellular_component nuclear periphery;GO:0034644,biological_process cellular response to UV;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036003,biological_process positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0036091,biological_process positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0036499,biological_process PERK-mediated unfolded protein response;GO:0042149,biological_process cellular response to glucose starvation;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043267,biological_process negative regulation of potassium ion transport;GO:0043522,molecular_function leucine zipper domain binding;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048511,biological_process rhythmic process;GO:0061395,biological_process positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1903204,biological_process negative regulation of oxidative stress-induced neuron death;GO:1903351,biological_process cellular response to dopamine;GO:1990037,cellular_component Lewy body core;GO:1990440,biological_process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:1990589,cellular_component ATF4-CREB1 transcription factor complex;GO:1990590,cellular_component ATF1-ATF4 transcription factor complex;GO:1990617,cellular_component CHOP-ATF4 complex;GO:1990737,biological_process response to manganese-induced endoplasmic reticulum stress	ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4; K04374	activating transcription factor 4 [Source:HGNC Symbol%3BAcc:HGNC:786]
ENSG00000161328	0.65	0.82	0.54	1.01	0.47	0.43	0.0732294337459737	0.267828401280412	0.849506410656385	0.969426886313776	11:537526-554916:+	LRRC56	NA	NA	leucine rich repeat containing 56 [Source:HGNC Symbol%3BAcc:HGNC:25430]
ENSG00000107771	13.22	12.75	13.82	13.90	12.61	14.03	-0.0139563527126083	5.47796492732418	0.849546899969488	0.969426886313776	10:84328585-84518521:+	CCSER2	3;GO:0001578,biological_process microtubule bundle formation;GO:0008017,molecular_function microtubule binding;GO:0015630,cellular_component microtubule cytoskeleton	NA	coiled-coil serine rich protein 2 [Source:HGNC Symbol%3BAcc:HGNC:29197]
ENSG00000109705	0.99	1.43	0.37	0.82	0.68	1.48	-0.139178599074499	0.140625481091632	0.849810182757715	0.969558402552167	4:13540829-13545050:-	NKX3-2	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007368,biological_process determination of left/right symmetry;GO:0031016,biological_process pancreas development;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0042474,biological_process middle ear morphogenesis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048513,biological_process animal organ development;GO:0048536,biological_process spleen development;GO:0048645,biological_process organ formation;GO:0048705,biological_process skeletal system morphogenesis;GO:0048706,biological_process embryonic skeletal system development;GO:0055123,biological_process digestive system development;GO:0060576,biological_process intestinal epithelial cell development	NA	NK3 homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:951]
ENSG00000189114	7.11	5.68	4.74	6.42	6.38	4.29	0.0560735880888727	1.86739050833695	0.849823990900918	0.969558402552167	19:45178744-45181801:+	BLOC1S3	17;GO:0001654,biological_process eye development;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008089,biological_process anterograde axonal transport;GO:0030133,cellular_component transport vesicle;GO:0030168,biological_process platelet activation;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0032402,biological_process melanosome transport;GO:0032438,biological_process melanosome organization;GO:0035646,biological_process endosome to melanosome transport;GO:0043473,biological_process pigmentation;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0060155,biological_process platelet dense granule organization;GO:1904115,cellular_component axon cytoplasm	NA	biogenesis of lysosomal organelles complex 1 subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:20914]
ENSG00000079335	2.67	2.24	2.85	3.09	2.01	2.98	-0.0392073640433458	2.42342566089445	0.849896477738671	0.969558402552167	1:100345024-100520277:+	CDC14A	30;GO:0000922,cellular_component spindle pole;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0007096,biological_process regulation of exit from mitosis;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008283,biological_process cell proliferation;GO:0016311,biological_process dephosphorylation;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042995,cellular_component cell projection;GO:0051256,biological_process mitotic spindle midzone assembly;GO:0051301,biological_process cell division;GO:0060091,cellular_component kinocilium;GO:0060271,biological_process cilium morphogenesis;GO:0071850,biological_process mitotic cell cycle arrest;GO:0072686,cellular_component mitotic spindle	CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]; K06639	cell division cycle 14A [Source:HGNC Symbol%3BAcc:HGNC:1718]
ENSG00000100227	46.68	48.21	45.09	45.46	47.45	46.91	0.0117216853473548	6.10161480037256	0.850101882053928	0.969611340543309	22:42583720-42614962:-	POLDIP3	21;GO:0000346,cellular_component transcription export complex;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006417,biological_process regulation of translation;GO:0006810,biological_process transport;GO:0016607,cellular_component nuclear speck;GO:0016973,biological_process poly(A)+ mRNA export from nucleus;GO:0031124,biological_process mRNA 3'-end processing;GO:0035145,cellular_component exon-exon junction complex;GO:0045727,biological_process positive regulation of translation;GO:0051028,biological_process mRNA transport	NA	DNA polymerase delta interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:23782]
ENSG00000197147	2.29	1.39	2.47	2.18	2.11	2.16	-0.0319230066443501	2.39817833699631	0.850139881900822	0.969611340543309	1:89524835-89597864:+	LRRC8B	15;GO:0005225,molecular_function volume-sensitive anion channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034702,cellular_component ion channel complex;GO:0044070,biological_process regulation of anion transport;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	leucine rich repeat containing 8 family member B [Source:HGNC Symbol%3BAcc:HGNC:30692]
ENSG00000179361	4.24	3.41	3.54	3.83	4.01	3.22	0.0411203371019118	2.67970564980846	0.850195358118217	0.969611340543309	15:74541176-74598131:+	ARID3B	15;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008150,biological_process biological_process;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	AT-rich interaction domain 3B [Source:HGNC Symbol%3BAcc:HGNC:14350]
ENSG00000104957	29.40	27.04	32.17	30.61	28.43	31.41	-0.0141116105709701	5.34092291204058	0.850255332459028	0.969611340543309	19:13731759-13763296:+	CCDC130	3;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0009615,biological_process response to virus	NA	coiled-coil domain containing 130 [Source:HGNC Symbol%3BAcc:HGNC:28118]
ENSG00000118298	0.78	0.79	1.55	1.17	1.04	0.77	0.0978817319327479	0.340957799189638	0.850510067698855	0.969812738411344	1:150257158-150265078:+	CA14	7;GO:0004089,molecular_function carbonate dehydratase activity;GO:0005886,cellular_component plasma membrane;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0046872,molecular_function metal ion binding	CA; carbonic anhydrase [EC:4.2.1.1]; K01672	carbonic anhydrase 14 [Source:HGNC Symbol%3BAcc:HGNC:1372]
ENSG00000136940	22.78	21.55	19.06	21.73	22.01	19.27	0.0211016511139146	4.29818068573505	0.85062019415186	0.969849221090019	9:122798388-122828631:-	PDCL	14;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0007601,biological_process visual perception;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0008479,molecular_function queuine tRNA-ribosyltransferase activity;GO:0008616,biological_process queuosine biosynthetic process;GO:0032403,molecular_function protein complex binding;GO:0050896,biological_process response to stimulus;GO:0061084,biological_process negative regulation of protein refolding;GO:1902605,biological_process heterotrimeric G-protein complex assembly	NA	phosducin like [Source:HGNC Symbol%3BAcc:HGNC:8770]
ENSG00000159259	13.48	14.76	14.57	14.78	12.93	14.84	0.0160893630552371	4.5853930126409	0.850755229354522	0.969914094597509	21:36385377-36419015:+	CHAF1B	19;GO:0000790,cellular_component nuclear chromatin;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006461,biological_process protein complex assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0031497,biological_process chromatin assembly;GO:0033186,cellular_component CAF-1 complex;GO:0042393,molecular_function histone binding;GO:0043234,cellular_component protein complex;GO:0051082,molecular_function unfolded protein binding	NA	chromatin assembly factor 1 subunit B [Source:HGNC Symbol%3BAcc:HGNC:1911]
ENSG00000188283	5.10	4.44	5.91	6.06	5.03	4.90	-0.0260434380769055	3.01556691479988	0.85094709684304	0.970010345499054	19:37217925-37248738:+	ZNF383	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031965,cellular_component nuclear membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 383 [Source:HGNC Symbol%3BAcc:HGNC:18609]
ENSG00000167554	3.62	3.45	3.13	3.78	3.28	3.50	-0.0398231021282903	2.30816554336741	0.851082399515828	0.970010345499054	19:52336244-52367778:+	ZNF610	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 610 [Source:HGNC Symbol%3BAcc:HGNC:26687]
ENSG00000119820	58.72	51.29	52.86	58.11	51.83	56.20	-0.0138447522523245	5.42071475560984	0.851114702828829	0.970010345499054	2:32277909-32316594:+	YIPF4	7;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	Yip1 domain family member 4 [Source:HGNC Symbol%3BAcc:HGNC:28145]
ENSG00000171345	356.90	394.53	341.33	361.63	385.53	364.37	-0.0132872290356607	8.78535810111195	0.851229842095992	0.970010345499054	17:41523616-41528308:-	KRT19	23;GO:0005198,molecular_function structural molecule activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0007219,biological_process Notch signaling pathway;GO:0008307,molecular_function structural constituent of muscle;GO:0016010,cellular_component dystrophin-associated glycoprotein complex;GO:0016032,biological_process viral process;GO:0016327,cellular_component apicolateral plasma membrane;GO:0030018,cellular_component Z disc;GO:0031424,biological_process keratinization;GO:0032403,molecular_function protein complex binding;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0043627,biological_process response to estrogen;GO:0045214,biological_process sarcomere organization;GO:0060706,biological_process cell differentiation involved in embryonic placenta development;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0071944,cellular_component cell periphery;GO:1990357,cellular_component terminal web	KRT1; type I keratin, acidic; K07604	keratin 19 [Source:HGNC Symbol%3BAcc:HGNC:6436]
ENSG00000010244	89.93	94.26	90.81	92.76	96.58	90.18	-0.0123800774992495	7.15523179681072	0.851230378918972	0.970010345499054	17:32350116-32381886:+	ZNF207	33;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0001578,biological_process microtubule bundle formation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0008017,molecular_function microtubule binding;GO:0008201,molecular_function heparin binding;GO:0008270,molecular_function zinc ion binding;GO:0008608,biological_process attachment of spindle microtubules to kinetochore;GO:0046785,biological_process microtubule polymerization;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0051301,biological_process cell division;GO:0051983,biological_process regulation of chromosome segregation;GO:0090307,biological_process mitotic spindle assembly;GO:1990047,cellular_component spindle matrix	NA	zinc finger protein 207 [Source:HGNC Symbol%3BAcc:HGNC:12998]
ENSG00000071246	1.56	2.04	1.83	1.65	2.09	1.89	-0.0570255204729813	1.49237344163468	0.851351338371375	0.970059130090314	14:76762188-76783015:+	VASH1	19;GO:0001525,biological_process angiogenesis;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0009611,biological_process response to wounding;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0016525,biological_process negative regulation of angiogenesis;GO:0043537,biological_process negative regulation of blood vessel endothelial cell migration;GO:0045177,cellular_component apical part of cell;GO:0045765,biological_process regulation of angiogenesis;GO:0060674,biological_process placenta blood vessel development;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:1901491,biological_process negative regulation of lymphangiogenesis;GO:2000772,biological_process regulation of cellular senescence	NA	vasohibin 1 [Source:HGNC Symbol%3BAcc:HGNC:19964]
ENSG00000130479	8.78	8.15	8.34	8.11	9.32	8.37	-0.0149648022152257	4.92822832182609	0.851573378533971	0.970114666130947	19:17719241-17734516:+	MAP1S	30;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001578,biological_process microtubule bundle formation;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0008017,molecular_function microtubule binding;GO:0010848,biological_process regulation of chromatin disassembly;GO:0015630,cellular_component microtubule cytoskeleton;GO:0015631,molecular_function tubulin binding;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0045202,cellular_component synapse;GO:0047497,biological_process mitochondrion transport along microtubule;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048487,molecular_function beta-tubulin binding;GO:0048812,biological_process neuron projection morphogenesis;GO:0051015,molecular_function actin filament binding	NA	microtubule associated protein 1S [Source:HGNC Symbol%3BAcc:HGNC:15715]
ENSG00000138792	87.05	89.68	86.58	80.65	99.84	87.65	-0.0145465806950752	7.99454174119749	0.851610189207772	0.970114666130947	4:110365732-110565285:+	ENPEP	29;GO:0001525,biological_process angiogenesis;GO:0002003,biological_process angiotensin maturation;GO:0002005,biological_process angiotensin catabolic process in blood;GO:0003081,biological_process regulation of systemic arterial blood pressure by renin-angiotensin;GO:0004177,molecular_function aminopeptidase activity;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005903,cellular_component brush border;GO:0006508,biological_process proteolysis;GO:0007267,biological_process cell-cell signaling;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032835,biological_process glomerulus development;GO:0042277,molecular_function peptide binding;GO:0043171,biological_process peptide catabolic process;GO:0045177,cellular_component apical part of cell;GO:0046872,molecular_function metal ion binding;GO:0070006,molecular_function metalloaminopeptidase activity;GO:0070062,cellular_component extracellular exosome	ENPEP, CD249; glutamyl aminopeptidase [EC:3.4.11.7]; K11141	glutamyl aminopeptidase [Source:HGNC Symbol%3BAcc:HGNC:3355]
ENSG00000138398	33.32	31.06	30.13	30.78	34.13	31.30	-0.0128839285581632	6.28114122219438	0.851634537728908	0.970114666130947	2:169584339-169641406:+	PPIG	13;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0008380,biological_process RNA splicing;GO:0016018,molecular_function cyclosporin A binding;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0016853,molecular_function isomerase activity	NA	peptidylprolyl isomerase G [Source:HGNC Symbol%3BAcc:HGNC:14650]
ENSG00000131462	31.41	39.54	33.31	34.64	38.08	33.49	-0.0199495012113522	5.6116826333019	0.85197264271588	0.970410755554434	17:42609675-42615234:+	TUBG1	32;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000212,biological_process meiotic spindle organization;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000242,cellular_component pericentriolar material;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000930,cellular_component gamma-tubulin complex;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005827,cellular_component polar microtubule;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005929,cellular_component cilium;GO:0007017,biological_process microtubule-based process;GO:0007020,biological_process microtubule nucleation;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031252,cellular_component cell leading edge;GO:0036064,cellular_component ciliary basal body;GO:0045177,cellular_component apical part of cell;GO:0055037,cellular_component recycling endosome;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:0097730,cellular_component non-motile cilium	TUBG; tubulin gamma; K10389	tubulin gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:12417]
ENSG00000180964	100.61	107.00	95.62	103.88	100.69	97.56	0.0133153980886927	5.15147849621282	0.852490770680624	0.970837272079537	X:103252994-103255203:-	TCEAL8	5;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0050699,molecular_function WW domain binding	NA	transcription elongation factor A like 8 [Source:HGNC Symbol%3BAcc:HGNC:28683]
ENSG00000119139	8.24	8.88	7.84	8.41	8.31	8.67	-0.0179905342721751	5.06045149314688	0.852664961769427	0.970837272079537	9:69121263-69255208:+	TJP2	25;GO:0004385,molecular_function guanylate kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005923,cellular_component bicellular tight junction;GO:0008022,molecular_function protein C-terminus binding;GO:0010033,biological_process response to organic substance;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030674,molecular_function protein binding, bridging;GO:0035329,biological_process hippo signaling;GO:0045296,molecular_function cadherin binding;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0050892,biological_process intestinal absorption;GO:0070160,cellular_component occluding junction;GO:0071847,biological_process TNFSF11-mediated signaling pathway;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:0090559,biological_process regulation of membrane permeability;GO:2001205,biological_process negative regulation of osteoclast development	TJP2, ZO2; tight junction protein 2; K06098	tight junction protein 2 [Source:HGNC Symbol%3BAcc:HGNC:11828]
ENSG00000205143	1.26	0.54	1.01	0.67	0.80	1.19	0.126196527032277	0.382409568440045	0.852666150461883	0.970837272079537	9:34621378-34628107:-	ARID3C	11;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045121,cellular_component membrane raft;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	AT-rich interaction domain 3C [Source:HGNC Symbol%3BAcc:HGNC:21209]
ENSG00000146005	0.49	0.58	0.35	0.68	0.20	0.46	0.0772098005890477	0.26749758010243	0.852726666200594	0.970837272079537	5:139795820-139844466:+	PSD2	12;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005543,molecular_function phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0032154,cellular_component cleavage furrow;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043547,biological_process positive regulation of GTPase activity	PSD; PH and SEC7 domain-containing protein; K12494	pleckstrin and Sec7 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:19092]
ENSG00000215301	78.45	73.05	73.99	71.44	78.03	76.02	0.0123770772950478	7.43098943797951	0.852775183963864	0.970837272079537	X:41333347-41364472:+	DDX3X	77;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006417,biological_process regulation of translation;GO:0006915,biological_process apoptotic process;GO:0007059,biological_process chromosome segregation;GO:0008134,molecular_function transcription factor binding;GO:0008143,molecular_function poly(A) binding;GO:0008190,molecular_function eukaryotic initiation factor 4E binding;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0009615,biological_process response to virus;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016055,biological_process Wnt signaling pathway;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0017148,biological_process negative regulation of translation;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030307,biological_process positive regulation of cell growth;GO:0030308,biological_process negative regulation of cell growth;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031369,molecular_function translation initiation factor binding;GO:0032508,biological_process DNA duplex unwinding;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0033592,molecular_function RNA strand annealing activity;GO:0034063,biological_process stress granule assembly;GO:0034774,cellular_component secretory granule lumen;GO:0035556,biological_process intracellular signal transduction;GO:0035613,molecular_function RNA stem-loop binding;GO:0042254,biological_process ribosome biogenesis;GO:0042256,biological_process mature ribosome assembly;GO:0043024,molecular_function ribosomal small subunit binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043273,molecular_function CTPase activity;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043312,biological_process neutrophil degranulation;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045296,molecular_function cadherin binding;GO:0045727,biological_process positive regulation of translation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045948,biological_process positive regulation of translational initiation;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070062,cellular_component extracellular exosome;GO:0071243,biological_process cellular response to arsenic-containing substance;GO:0071470,biological_process cellular response to osmotic stress;GO:0071651,biological_process positive regulation of chemokine (C-C motif) ligand 5 production;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1903608,biological_process protein localization to cytoplasmic stress granule;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]; K11594	DEAD-box helicase 3%2C X-linked [Source:HGNC Symbol%3BAcc:HGNC:2745]
ENSG00000167202	6.93	6.96	5.96	6.41	6.89	6.94	-0.0207072127575932	4.43354365961668	0.852892256793246	0.970837272079537	15:77984035-78077724:-	TBC1D2B	8;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 2B [Source:HGNC Symbol%3BAcc:HGNC:29183]
ENSG00000168958	68.49	73.02	68.22	73.56	66.60	73.06	-0.0143445837030442	6.17977705278078	0.852894582456082	0.970837272079537	2:227325150-227357836:+	MFF	25;GO:0000266,biological_process mitochondrial fission;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0006626,biological_process protein targeting to mitochondrion;GO:0008021,cellular_component synaptic vesicle;GO:0008053,biological_process mitochondrial fusion;GO:0010821,biological_process regulation of mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016559,biological_process peroxisome fission;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032592,cellular_component integral component of mitochondrial membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0045202,cellular_component synapse;GO:0051260,biological_process protein homooligomerization;GO:0070584,biological_process mitochondrion morphogenesis;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1900063,biological_process regulation of peroxisome organization	NA	mitochondrial fission factor [Source:HGNC Symbol%3BAcc:HGNC:24858]
ENSG00000111817	20.79	18.92	21.20	20.84	19.63	21.58	-0.0121706635639325	5.88641831849899	0.853173259080683	0.970945815805313	6:116254172-116444860:+	DSE	12;GO:0000139,cellular_component Golgi membrane;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016853,molecular_function isomerase activity;GO:0030206,biological_process chondroitin sulfate biosynthetic process;GO:0030208,biological_process dermatan sulfate biosynthetic process;GO:0047757,molecular_function chondroitin-glucuronate 5-epimerase activity	DSE; chondroitin-glucuronate 5-epimerase [EC:5.1.3.19]; K01794	dermatan sulfate epimerase [Source:HGNC Symbol%3BAcc:HGNC:21144]
ENSG00000169021	104.13	105.91	95.72	101.74	102.23	101.46	0.0119432149684536	6.39066987567819	0.853233985548993	0.970945815805313	19:29205320-29213541:-	UQCRFS1	23;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0009725,biological_process response to hormone;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016679,molecular_function oxidoreductase activity, acting on diphenols and related substances as donors;GO:0031966,cellular_component mitochondrial membrane;GO:0032403,molecular_function protein complex binding;GO:0042493,biological_process response to drug;GO:0043209,cellular_component myelin sheath;GO:0046677,biological_process response to antibiotic;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]; K00411	ubiquinol-cytochrome c reductase%2C Rieske iron-sulfur polypeptide 1 [Source:HGNC Symbol%3BAcc:HGNC:12587]
ENSG00000137409	89.61	88.45	86.59	89.27	86.92	88.49	0.0114592541008378	7.00273109698924	0.853319437646819	0.970945815805313	6:36968140-36986298:-	MTCH1	12;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045161,biological_process neuronal ion channel clustering	NA	mitochondrial carrier 1 [Source:HGNC Symbol%3BAcc:HGNC:17586]
ENSG00000121644	15.80	17.56	18.97	20.52	14.94	18.23	-0.0276281382535591	3.59522469671711	0.853322252858387	0.970945815805313	1:244652934-244709033:+	DESI2	4;GO:0005737,cellular_component cytoplasm;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity	NA	desumoylating isopeptidase 2 [Source:HGNC Symbol%3BAcc:HGNC:24264]
ENSG00000100099	30.57	26.27	30.90	30.78	28.05	30.62	-0.0126652234788188	6.09563822631106	0.853381131618156	0.970945815805313	22:26443422-26483837:-	HPS4	25;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006605,biological_process protein targeting;GO:0006996,biological_process organelle organization;GO:0007040,biological_process lysosome organization;GO:0007596,biological_process blood coagulation;GO:0007599,biological_process hemostasis;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030318,biological_process melanocyte differentiation;GO:0031085,cellular_component BLOC-3 complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042470,cellular_component melanosome;GO:0042803,molecular_function protein homodimerization activity;GO:0042827,cellular_component platelet dense granule;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046983,molecular_function protein dimerization activity;GO:0048075,biological_process positive regulation of eye pigmentation;GO:0050821,biological_process protein stabilization;GO:0061024,biological_process membrane organization;GO:1903232,biological_process melanosome assembly;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	HPS4%2C biogenesis of lysosomal organelles complex 3 subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:15844]
ENSG00000107779	13.85	13.47	13.33	13.23	13.54	13.75	0.0167651018006138	4.44357601217841	0.853459260150791	0.970945815805313	10:86756600-86932838:+	BMPR1A	95;GO:0000166,molecular_function nucleotide binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001701,biological_process in utero embryonic development;GO:0001707,biological_process mesoderm formation;GO:0001756,biological_process somitogenesis;GO:0001880,biological_process Mullerian duct regression;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002062,biological_process chondrocyte differentiation;GO:0003007,biological_process heart morphogenesis;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003161,biological_process cardiac conduction system development;GO:0003183,biological_process mitral valve morphogenesis;GO:0003186,biological_process tricuspid valve morphogenesis;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003223,biological_process ventricular compact myocardium morphogenesis;GO:0003272,biological_process endocardial cushion formation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005886,cellular_component plasma membrane;GO:0005901,cellular_component caveola;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007389,biological_process pattern specification process;GO:0007398,biological_process ectoderm development;GO:0007399,biological_process nervous system development;GO:0007492,biological_process endoderm development;GO:0007507,biological_process heart development;GO:0009897,cellular_component external side of plasma membrane;GO:0009950,biological_process dorsal/ventral axis specification;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0014032,biological_process neural crest cell development;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019827,biological_process stem cell population maintenance;GO:0021983,biological_process pituitary gland development;GO:0021998,biological_process neural plate mediolateral regionalization;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0030425,cellular_component dendrite;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0035137,biological_process hindlimb morphogenesis;GO:0035912,biological_process dorsal aorta morphogenesis;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042803,molecular_function protein homodimerization activity;GO:0043025,cellular_component neuronal cell body;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0048339,biological_process paraxial mesoderm development;GO:0048352,biological_process paraxial mesoderm structural organization;GO:0048368,biological_process lateral mesoderm development;GO:0048378,biological_process regulation of lateral mesodermal cell fate specification;GO:0048382,biological_process mesendoderm development;GO:0048568,biological_process embryonic organ development;GO:0048589,biological_process developmental growth;GO:0048598,biological_process embryonic morphogenesis;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050768,biological_process negative regulation of neurogenesis;GO:0051216,biological_process cartilage development;GO:0060021,biological_process palate development;GO:0060043,biological_process regulation of cardiac muscle cell proliferation;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060896,biological_process neural plate pattern specification;GO:0060914,biological_process heart formation;GO:0061312,biological_process BMP signaling pathway involved in heart development;GO:0061626,biological_process pharyngeal arch artery morphogenesis;GO:0071773,biological_process cellular response to BMP stimulus;GO:0098821,molecular_function BMP receptor activity;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1904414,biological_process positive regulation of cardiac ventricle development;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1905285,biological_process fibrous ring of heart morphogenesis;GO:1990712,cellular_component HFE-transferrin receptor complex;GO:2000772,biological_process regulation of cellular senescence	BMPR1A, ALK3, CD292; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]; K04673	bone morphogenetic protein receptor type 1A [Source:HGNC Symbol%3BAcc:HGNC:1076]
ENSG00000114450	7.06	7.87	6.42	6.97	7.36	6.69	0.0254751105600863	2.87375607956145	0.853718839173371	0.971071712523806	3:179396088-179451590:-	GNB4	10;GO:0004871,molecular_function signal transducer activity;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0021762,biological_process substantia nigra development;GO:0032403,molecular_function protein complex binding;GO:0043209,cellular_component myelin sheath;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus	GNB4; guanine nucleotide-binding protein subunit beta-4; K04538	G protein subunit beta 4 [Source:HGNC Symbol%3BAcc:HGNC:20731]
ENSG00000150991	324.26	317.34	322.16	328.67	318.21	317.75	0.01050558374559	9.36870654934205	0.85399727950693	0.971071712523806	12:124911603-124917368:-	UBC	96;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0000209,biological_process protein polyubiquitination;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0002020,molecular_function protease binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005978,biological_process glycogen biosynthetic process;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006457,biological_process protein folding;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007219,biological_process Notch signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016055,biological_process Wnt signaling pathway;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0019058,biological_process viral life cycle;GO:0019068,biological_process virion assembly;GO:0019985,biological_process translesion synthesis;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031982,cellular_component vesicle;GO:0032479,biological_process regulation of type I interferon production;GO:0032480,biological_process negative regulation of type I interferon production;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0034220,biological_process ion transmembrane transport;GO:0035635,biological_process entry of bacterium into host cell;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0036297,biological_process interstrand cross-link repair;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042059,biological_process negative regulation of epidermal growth factor receptor signaling pathway;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043657,cellular_component host cell;GO:0044267,biological_process cellular protein metabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0045087,biological_process innate immune response;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060544,biological_process regulation of necroptotic process;GO:0061024,biological_process membrane organization;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070987,biological_process error-free translesion synthesis;GO:0075733,biological_process intracellular transport of virus;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904380,biological_process endoplasmic reticulum mannose trimming	UBC; ubiquitin C; K08770	ubiquitin C [Source:HGNC Symbol%3BAcc:HGNC:12468]
ENSG00000163617	6.69	7.16	6.90	6.39	7.95	6.86	-0.020955678340932	4.34245827231673	0.854021389056511	0.971071712523806	3:113964136-114056613:-	CCDC191	NA	NA	coiled-coil domain containing 191 [Source:HGNC Symbol%3BAcc:HGNC:29272]
ENSG00000136999	8.64	12.67	11.68	8.60	13.31	10.44	0.0336065111216976	3.55452392201446	0.854045677405716	0.971071712523806	8:119416305-119424353:+	NOV	43;GO:0001525,biological_process angiogenesis;GO:0001558,biological_process regulation of cell growth;GO:0002062,biological_process chondrocyte differentiation;GO:0005112,molecular_function Notch binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005520,molecular_function insulin-like growth factor binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005921,cellular_component gap junction;GO:0007267,biological_process cell-cell signaling;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0010468,biological_process regulation of gene expression;GO:0010761,biological_process fibroblast migration;GO:0010832,biological_process negative regulation of myotube differentiation;GO:0014909,biological_process smooth muscle cell migration;GO:0030054,cellular_component cell junction;GO:0030308,biological_process negative regulation of cell growth;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031012,cellular_component extracellular matrix;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0035767,biological_process endothelial cell chemotaxis;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0043025,cellular_component neuronal cell body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044342,biological_process type B pancreatic cell proliferation;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0046676,biological_process negative regulation of insulin secretion;GO:0048659,biological_process smooth muscle cell proliferation;GO:0050728,biological_process negative regulation of inflammatory response;GO:0060326,biological_process cell chemotaxis;GO:0060392,biological_process negative regulation of SMAD protein import into nucleus;GO:0060548,biological_process negative regulation of cell death;GO:0061484,biological_process hematopoietic stem cell homeostasis;GO:0071603,biological_process endothelial cell-cell adhesion;GO:0090027,biological_process negative regulation of monocyte chemotaxis;GO:1902731,biological_process negative regulation of chondrocyte proliferation;GO:1904057,biological_process negative regulation of sensory perception of pain;GO:1990523,biological_process bone regeneration	NA	nephroblastoma overexpressed [Source:HGNC Symbol%3BAcc:HGNC:7885]
ENSG00000076685	57.66	59.18	60.63	60.54	59.26	60.58	-0.0118528930246485	6.83246186183038	0.854138655873896	0.971071712523806	10:103088016-103193306:-	NT5C2	17;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006195,biological_process purine nucleotide catabolic process;GO:0008152,biological_process metabolic process;GO:0008253,molecular_function 5'-nucleotidase activity;GO:0009117,biological_process nucleotide metabolic process;GO:0016310,biological_process phosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0017144,biological_process drug metabolic process;GO:0046040,biological_process IMP metabolic process;GO:0046085,biological_process adenosine metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050146,molecular_function nucleoside phosphotransferase activity	NA	5'-nucleotidase%2C cytosolic II [Source:HGNC Symbol%3BAcc:HGNC:8022]
ENSG00000198156	0.95	0.93	1.10	0.89	0.74	1.15	0.104686144878864	0.529816292970489	0.854156993471011	0.971071712523806	16:28342554-28363508:-	NPIPB6	1;GO:0005654,cellular_component nucleoplasm	NA	nuclear pore complex interacting protein family member B6 [Source:HGNC Symbol%3BAcc:HGNC:37454]
ENSG00000198894	5.71	6.85	6.19	6.24	5.88	6.33	0.0238534344872729	2.92018115848549	0.854197174324768	0.971071712523806	14:77098096-77117287:+	CIPC	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process	NA	CLOCK interacting pacemaker [Source:HGNC Symbol%3BAcc:HGNC:20365]
ENSG00000196547	8.29	8.14	7.80	7.66	8.27	8.24	0.0150940484726482	4.85535669545864	0.854243918886404	0.971071712523806	15:90902217-90922584:+	MAN2A2	19;GO:0000139,cellular_component Golgi membrane;GO:0003824,molecular_function catalytic activity;GO:0004559,molecular_function alpha-mannosidase activity;GO:0004572,molecular_function mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006013,biological_process mannose metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006491,biological_process N-glycan processing;GO:0006517,biological_process protein deglycosylation;GO:0008152,biological_process metabolic process;GO:0015923,molecular_function mannosidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0016799,molecular_function hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0030246,molecular_function carbohydrate binding;GO:0046872,molecular_function metal ion binding	MAN2; alpha-mannosidase II [EC:3.2.1.114]; K01231	mannosidase alpha class 2A member 2 [Source:HGNC Symbol%3BAcc:HGNC:6825]
ENSG00000133985	7.53	7.32	6.30	6.63	6.15	7.92	0.0359316073631574	2.26308868811957	0.85436845016657	0.971071712523806	14:70641786-70675360:+	TTC9	NA	NA	tetratricopeptide repeat domain 9 [Source:HGNC Symbol%3BAcc:HGNC:20267]
ENSG00000213015	32.99	36.49	34.38	28.88	34.98	39.11	0.0187150602372693	4.16440310617612	0.8544517211945	0.971071712523806	19:55635015-55643469:+	ZNF580	15;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002690,biological_process positive regulation of leukocyte chemotaxis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0046872,molecular_function metal ion binding;GO:0070301,biological_process cellular response to hydrogen peroxide	NA	zinc finger protein 580 [Source:HGNC Symbol%3BAcc:HGNC:29473]
ENSG00000123999	1.54	2.18	2.01	1.84	1.31	2.82	-0.0692995036796512	1.19699743562093	0.854468870012761	0.971071712523806	2:219569161-219575713:+	INHA	44;GO:0001501,biological_process skeletal system development;GO:0001541,biological_process ovarian follicle development;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005179,molecular_function hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007399,biological_process nervous system development;GO:0008083,molecular_function growth factor activity;GO:0008584,biological_process male gonad development;GO:0009605,biological_process response to external stimulus;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030154,biological_process cell differentiation;GO:0030218,biological_process erythrocyte differentiation;GO:0030509,biological_process BMP signaling pathway;GO:0034673,cellular_component inhibin-betaglycan-ActRII complex;GO:0034711,molecular_function inhibin binding;GO:0042127,biological_process regulation of cell proliferation;GO:0042326,biological_process negative regulation of phosphorylation;GO:0042541,biological_process hemoglobin biosynthetic process;GO:0042981,biological_process regulation of apoptotic process;GO:0043025,cellular_component neuronal cell body;GO:0043408,biological_process regulation of MAPK cascade;GO:0043512,cellular_component inhibin A complex;GO:0043513,cellular_component inhibin B complex;GO:0045077,biological_process negative regulation of interferon-gamma biosynthetic process;GO:0045578,biological_process negative regulation of B cell differentiation;GO:0045650,biological_process negative regulation of macrophage differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0046881,biological_process positive regulation of follicle-stimulating hormone secretion;GO:0046882,biological_process negative regulation of follicle-stimulating hormone secretion;GO:0046982,molecular_function protein heterodimerization activity;GO:0048468,biological_process cell development;GO:0051726,biological_process regulation of cell cycle;GO:0060395,biological_process SMAD protein signal transduction	INHA; inhibin, alpha; K05500	inhibin alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:6065]
ENSG00000113638	12.49	12.78	12.36	12.58	11.87	12.93	0.018280291666863	3.84470750151278	0.854558705127306	0.971071712523806	5:40512332-40755975:-	TTC33	1;GO:0005515,molecular_function protein binding	NA	tetratricopeptide repeat domain 33 [Source:HGNC Symbol%3BAcc:HGNC:29959]
ENSG00000131470	17.88	18.68	18.84	20.01	17.49	17.51	0.0211798573655106	3.72592941867803	0.854631897901483	0.971071712523806	17:42572314-42577831:-	PSMC3IP	9;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006310,biological_process DNA recombination;GO:0007131,biological_process reciprocal meiotic recombination;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0051321,biological_process meiotic cell cycle;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	PSMC3 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:17928]
ENSG00000077232	65.38	69.65	63.59	64.91	71.13	65.89	-0.0129479383607902	7.32391929381977	0.854877214532863	0.971071712523806	2:182716040-182794464:+	DNAJC10	24;GO:0001671,molecular_function ATPase activator activity;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015036,molecular_function disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016671,molecular_function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030544,molecular_function Hsp70 protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0034663,cellular_component endoplasmic reticulum chaperone complex;GO:0034975,biological_process protein folding in endoplasmic reticulum;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0045454,biological_process cell redox homeostasis;GO:0051087,molecular_function chaperone binding;GO:0051117,molecular_function ATPase binding;GO:0051787,molecular_function misfolded protein binding;GO:0055114,biological_process oxidation-reduction process;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	DNAJC10; DnaJ homolog subfamily C member 10; K09530	DnaJ heat shock protein family (Hsp40) member C10 [Source:HGNC Symbol%3BAcc:HGNC:24637]
ENSG00000112394	1.70	1.60	1.18	1.39	1.31	2.00	-0.0676398452279629	1.39720127265859	0.855011296201821	0.971071712523806	6:111087502-111231194:+	SLC16A10	16;GO:0003333,biological_process amino acid transmembrane transport;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006865,biological_process amino acid transport;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015173,molecular_function aromatic amino acid transmembrane transporter activity;GO:0015349,molecular_function thyroid hormone transmembrane transporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0015801,biological_process aromatic amino acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0055085,biological_process transmembrane transport;GO:0070327,biological_process thyroid hormone transport	SLC16A10; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 10; K08187	solute carrier family 16 member 10 [Source:HGNC Symbol%3BAcc:HGNC:17027]
ENSG00000102218	12.98	10.83	12.13	11.20	11.77	12.79	0.0264103533733017	3.67225910251423	0.855190667237441	0.971071712523806	X:46836939-46882358:+	RP2	26;GO:0000166,molecular_function nucleotide binding;GO:0003779,molecular_function actin binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005814,cellular_component centriole;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006457,biological_process protein folding;GO:0006810,biological_process transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0007010,biological_process cytoskeleton organization;GO:0007601,biological_process visual perception;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0031410,cellular_component cytoplasmic vesicle;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051082,molecular_function unfolded protein binding;GO:0070062,cellular_component extracellular exosome;GO:1990075,cellular_component periciliary membrane compartment	NA	RP2%2C ARL3 GTPase activating protein [Source:HGNC Symbol%3BAcc:HGNC:10274]
ENSG00000112763	24.12	21.66	23.11	23.23	22.98	24.01	-0.0122243540867166	5.2546099811946	0.855193055022977	0.971071712523806	6:26457903-26476621:+	BTN2A1	7;GO:0003674,molecular_function molecular_function;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	butyrophilin subfamily 2 member A1 [Source:HGNC Symbol%3BAcc:HGNC:1136]
ENSG00000187790	2.11	2.02	1.82	1.90	2.21	1.99	-0.0234989409945474	3.66897091503525	0.855206732876989	0.971071712523806	14:45135939-45200890:+	FANCM	18;GO:0000166,molecular_function nucleotide binding;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004386,molecular_function helicase activity;GO:0004518,molecular_function nuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016787,molecular_function hydrolase activity;GO:0031297,biological_process replication fork processing;GO:0036297,biological_process interstrand cross-link repair;GO:0043240,cellular_component Fanconi anaemia nuclear complex;GO:0071821,cellular_component FANCM-MHF complex;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	FANCM; fanconi anemia group M protein; K10896	Fanconi anemia complementation group M [Source:HGNC Symbol%3BAcc:HGNC:23168]
ENSG00000141526	220.93	225.54	212.62	219.14	218.16	232.28	-0.0112322712784432	8.56451190599424	0.855214346258676	0.971071712523806	17:82228396-82261129:+	SLC16A3	17;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006090,biological_process pyruvate metabolic process;GO:0006810,biological_process transport;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015129,molecular_function lactate transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0035873,biological_process lactate transmembrane transport;GO:0035879,biological_process plasma membrane lactate transport;GO:0050900,biological_process leukocyte migration;GO:0055085,biological_process transmembrane transport	SLC16A3; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 3; K08180	solute carrier family 16 member 3 [Source:HGNC Symbol%3BAcc:HGNC:10924]
ENSG00000123908	8.39	7.60	7.65	7.96	7.45	8.16	0.0191026212396551	4.35501721643912	0.85534346975557	0.971071712523806	8:140520155-140635619:-	AGO2	65;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0000993,molecular_function RNA polymerase II core binding;GO:0001047,molecular_function core promoter binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0005845,cellular_component mRNA cap binding complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0008022,molecular_function protein C-terminus binding;GO:0009791,biological_process post-embryonic development;GO:0010501,biological_process RNA secondary structure unwinding;GO:0010586,biological_process miRNA metabolic process;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016442,cellular_component RISC complex;GO:0016787,molecular_function hydrolase activity;GO:0030054,cellular_component cell junction;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0030425,cellular_component dendrite;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035087,biological_process siRNA loading onto RISC involved in RNA interference;GO:0035194,biological_process posttranscriptional gene silencing by RNA;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0035197,molecular_function siRNA binding;GO:0035198,molecular_function miRNA binding;GO:0035278,biological_process miRNA mediated inhibition of translation;GO:0035279,biological_process mRNA cleavage involved in gene silencing by miRNA;GO:0035280,biological_process miRNA loading onto RISC involved in gene silencing by miRNA;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045947,biological_process negative regulation of translational initiation;GO:0046872,molecular_function metal ion binding;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0060213,biological_process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070062,cellular_component extracellular exosome;GO:0070551,molecular_function endoribonuclease activity, cleaving siRNA-paired mRNA;GO:0070578,cellular_component RISC-loading complex;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0090624,molecular_function endoribonuclease activity, cleaving miRNA-paired mRNA;GO:0090625,biological_process mRNA cleavage involved in gene silencing by siRNA;GO:0098808,molecular_function mRNA cap binding;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1905618,biological_process positive regulation of miRNA mediated inhibition of translation	ELF2C, AGO; eukaryotic translation initiation factor 2C; K11593	argonaute 2%2C RISC catalytic component [Source:HGNC Symbol%3BAcc:HGNC:3263]
ENSG00000111596	23.93	24.79	21.60	22.32	25.82	23.46	-0.0165169182197768	5.52359395834655	0.85540394978791	0.971071712523806	12:70242993-70354993:+	CNOT2	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001226,molecular_function RNA polymerase II transcription corepressor binding;GO:0001829,biological_process trophectodermal cell differentiation;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006417,biological_process regulation of translation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007275,biological_process multicellular organism development;GO:0010606,biological_process positive regulation of cytoplasmic mRNA processing body assembly;GO:0016020,cellular_component membrane;GO:0017148,biological_process negative regulation of translation;GO:0030014,cellular_component CCR4-NOT complex;GO:0030015,cellular_component CCR4-NOT core complex;GO:0031047,biological_process gene silencing by RNA;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:2000036,biological_process regulation of stem cell population maintenance	CNOT2, NOT2; CCR4-NOT transcription complex subunit 2; K12605	CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:7878]
ENSG00000064995	38.83	33.36	35.93	37.85	34.51	38.21	-0.0152924709015304	4.54156860573096	0.855428413196122	0.971071712523806	6:34877777-34888089:-	TAF11	19;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042809,molecular_function vitamin D receptor binding;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF11; transcription initiation factor TFIID subunit 11; K03135	TATA-box binding protein associated factor 11 [Source:HGNC Symbol%3BAcc:HGNC:11544]
ENSG00000198663	42.56	38.24	40.96	42.86	41.06	40.19	-0.011746048981505	5.45097754006851	0.855436749585572	0.971071712523806	6:36871869-36928964:+	C6orf89	14;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030496,cellular_component midbody;GO:0042060,biological_process wound healing;GO:0045787,biological_process positive regulation of cell cycle;GO:0050673,biological_process epithelial cell proliferation;GO:1901727,biological_process positive regulation of histone deacetylase activity	NA	chromosome 6 open reading frame 89 [Source:HGNC Symbol%3BAcc:HGNC:21114]
ENSG00000179598	3.74	3.29	3.41	4.16	3.51	2.51	0.0581803231378443	1.45900649256376	0.855479077106594	0.971071712523806	17:17200994-17206315:-	PLD6	25;GO:0003824,molecular_function catalytic activity;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0008053,biological_process mitochondrial fusion;GO:0010636,biological_process positive regulation of mitochondrial fusion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0030719,biological_process P granule organization;GO:0034587,biological_process piRNA metabolic process;GO:0035755,molecular_function cardiolipin hydrolase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043046,biological_process DNA methylation involved in gamete generation;GO:0046872,molecular_function metal ion binding;GO:0051321,biological_process meiotic cell cycle;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	phospholipase D family member 6 [Source:HGNC Symbol%3BAcc:HGNC:30447]
ENSG00000170468	5.88	5.81	5.78	5.65	5.80	5.89	0.0230184063826836	3.49976765727834	0.855525678575714	0.971071712523806	14:73490963-73493392:+	RIOX1	21;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0030961,biological_process peptidyl-arginine hydroxylation;GO:0032453,molecular_function histone demethylase activity (H3-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation	NA	ribosomal oxygenase 1 [Source:HGNC Symbol%3BAcc:HGNC:20968]
ENSG00000115935	16.63	18.61	18.79	16.64	18.99	19.42	-0.0188865829237301	4.93054935310232	0.855680805147162	0.971158986403193	2:174559571-174682916:-	WIPF1	17;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005522,molecular_function profilin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0006461,biological_process protein complex assembly;GO:0008154,biological_process actin polymerization or depolymerization;GO:0015629,cellular_component actin cytoskeleton;GO:0017124,molecular_function SH3 domain binding;GO:0030048,biological_process actin filament-based movement;GO:0031410,cellular_component cytoplasmic vesicle;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0051707,biological_process response to other organism	NA	WAS/WASL interacting protein family member 1 [Source:HGNC Symbol%3BAcc:HGNC:12736]
ENSG00000176248	9.85	8.87	9.25	7.71	10.52	10.44	-0.0212074248149375	4.55370741075464	0.855944696289897	0.971313043188961	9:137174783-137188549:-	ANAPC2	23;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005680,cellular_component anaphase-promoting complex;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0016567,biological_process protein ubiquitination;GO:0030154,biological_process cell differentiation;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031915,biological_process positive regulation of synaptic plasticity;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045773,biological_process positive regulation of axon extension;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0051301,biological_process cell division;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051439,biological_process regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0090129,biological_process positive regulation of synapse maturation	APC2; anaphase-promoting complex subunit 2; K03349	anaphase promoting complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:19989]
ENSG00000156026	24.56	29.04	27.36	26.17	28.97	27.24	-0.0173608642703848	5.5060815147491	0.85618178812139	0.971313043188961	10:72692130-72887694:+	MCU	23;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0015292,molecular_function uniporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019722,biological_process calcium-mediated signaling;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0032024,biological_process positive regulation of insulin secretion;GO:0034704,cellular_component calcium channel complex;GO:0035786,biological_process protein complex oligomerization;GO:0036444,biological_process calcium ion transmembrane import into mitochondrion;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0051560,biological_process mitochondrial calcium ion homeostasis;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0070588,biological_process calcium ion transmembrane transport;GO:1990246,cellular_component uniplex complex	NA	mitochondrial calcium uniporter [Source:HGNC Symbol%3BAcc:HGNC:23526]
ENSG00000158691	5.50	5.64	5.48	5.99	5.06	5.98	-0.0268692323082085	3.36775902197965	0.856186978772595	0.971313043188961	6:28378954-28399734:-	ZSCAN12	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 12 [Source:HGNC Symbol%3BAcc:HGNC:13172]
ENSG00000116350	57.49	60.93	56.14	59.33	56.69	58.43	0.0111847253295352	6.78522806657226	0.856210977713443	0.971313043188961	1:29147742-29181987:-	SRSF4	17;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0032868,biological_process response to insulin;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:1990825,molecular_function sequence-specific mRNA binding	SFRS4_5_6; splicing factor, arginine/serine-rich 4/5/6; K12893	serine and arginine rich splicing factor 4 [Source:HGNC Symbol%3BAcc:HGNC:10786]
ENSG00000054282	9.29	8.12	10.39	8.64	9.08	9.99	0.0229135169035147	4.46687851548612	0.856286841167718	0.971313043188961	1:243256033-243500092:+	SDCCAG8	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005911,cellular_component cell-cell junction;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0030010,biological_process establishment of cell polarity;GO:0030054,cellular_component cell junction;GO:0031023,biological_process microtubule organizing center organization;GO:0034451,cellular_component centriolar satellite;GO:0035148,biological_process tube formation;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	serologically defined colon cancer antigen 8 [Source:HGNC Symbol%3BAcc:HGNC:10671]
ENSG00000113643	55.78	60.04	52.66	54.35	59.21	54.67	0.0123357316865457	6.88131055174268	0.856345229714535	0.971313043188961	5:168486444-168519299:+	RARS	20;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004814,molecular_function arginine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006420,biological_process arginyl-tRNA aminoacylation;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0034618,molecular_function arginine binding;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]; K01887	arginyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:9870]
ENSG00000177692	4.13	2.22	3.35	3.22	3.52	3.50	-0.0398160896827658	2.0255497173796	0.856364291038426	0.971313043188961	21:33485529-33491720:-	DNAJC28	6;GO:0000301,biological_process retrograde transport, vesicle recycling within Golgi;GO:0005515,molecular_function protein binding;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0017119,cellular_component Golgi transport complex;GO:0048213,biological_process Golgi vesicle prefusion complex stabilization	NA	DnaJ heat shock protein family (Hsp40) member C28 [Source:HGNC Symbol%3BAcc:HGNC:1297]
ENSG00000271303	27.32	26.74	32.05	31.33	27.31	26.86	0.0273556509344878	3.57639569954309	0.856574950907176	0.971463212938399	20:646614-653370:-	SRXN1	12;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006979,biological_process response to oxidative stress;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016667,molecular_function oxidoreductase activity, acting on a sulfur group of donors;GO:0032542,molecular_function sulfiredoxin activity;GO:0034599,biological_process cellular response to oxidative stress;GO:0055114,biological_process oxidation-reduction process;GO:0098869,biological_process cellular oxidant detoxification	NA	sulfiredoxin 1 [Source:HGNC Symbol%3BAcc:HGNC:16132]
ENSG00000139496	8.51	6.57	8.51	8.37	7.60	7.52	0.0296823841436437	4.03940858158186	0.856950150695779	0.971799947066207	13:25301523-25349800:+	NUP58	31;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008139,molecular_function nuclear localization sequence binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0042306,biological_process regulation of protein import into nucleus;GO:0043234,cellular_component protein complex;GO:0043657,cellular_component host cell;GO:0051028,biological_process mRNA transport;GO:0051260,biological_process protein homooligomerization;GO:0051290,biological_process protein heterotetramerization;GO:0051291,biological_process protein heterooligomerization;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0070208,biological_process protein heterotrimerization;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUPL1, NUP49; nucleoporin p58/p45; K14307	nucleoporin 58 [Source:HGNC Symbol%3BAcc:HGNC:20261]
ENSG00000102309	34.12	31.64	29.67	31.53	33.39	30.25	0.0174138834505229	4.82672239235813	0.857302114555453	0.972078376915168	X:72181352-72302926:+	PIN4	14;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0016853,molecular_function isomerase activity;GO:0070062,cellular_component extracellular exosome	NA	peptidylprolyl cis/trans isomerase%2C NIMA-interacting 4 [Source:HGNC Symbol%3BAcc:HGNC:8992]
ENSG00000009954	41.16	37.27	40.32	39.46	39.52	41.76	-0.0111261476242571	7.47495886708107	0.857408472049354	0.972078376915168	7:73440397-73522278:-	BAZ1B	33;GO:0000166,molecular_function nucleotide binding;GO:0000793,cellular_component condensed chromosome;GO:0003007,biological_process heart morphogenesis;GO:0003682,molecular_function chromatin binding;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005721,cellular_component pericentric heterochromatin;GO:0006302,biological_process double-strand break repair;GO:0006333,biological_process chromatin assembly or disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008270,molecular_function zinc ion binding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016572,biological_process histone phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0035173,molecular_function histone kinase activity;GO:0042393,molecular_function histone binding;GO:0043596,cellular_component nuclear replication fork;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0048096,biological_process chromatin-mediated maintenance of transcription;GO:0070577,molecular_function lysine-acetylated histone binding;GO:0071884,molecular_function vitamin D receptor activator activity;GO:2000273,biological_process positive regulation of receptor activity	NA	bromodomain adjacent to zinc finger domain 1B [Source:HGNC Symbol%3BAcc:HGNC:961]
ENSG00000131115	8.19	8.55	8.14	7.98	8.27	9.13	-0.0205759171509498	4.37502644055387	0.857521846238415	0.972078376915168	19:44207546-44237268:+	ZNF227	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 227 [Source:HGNC Symbol%3BAcc:HGNC:13020]
ENSG00000110713	29.16	30.44	27.36	28.81	29.81	28.31	0.0114549655298997	7.32651516926144	0.857554089420571	0.972078376915168	11:3671082-3797792:-	NUP98	55;GO:0000776,cellular_component kinetochore;GO:0000973,biological_process posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005215,molecular_function transporter activity;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006260,biological_process DNA replication;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006508,biological_process proteolysis;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0006999,biological_process nuclear pore organization;GO:0007062,biological_process sister chromatid cohesion;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031080,cellular_component nuclear pore outer ring;GO:0031965,cellular_component nuclear membrane;GO:0034398,biological_process telomere tethering at nuclear periphery;GO:0034399,cellular_component nuclear periphery;GO:0042277,molecular_function peptide binding;GO:0042405,cellular_component nuclear inclusion body;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043657,cellular_component host cell;GO:0044614,cellular_component nuclear pore cytoplasmic filaments;GO:0044615,cellular_component nuclear pore nuclear basket;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0051028,biological_process mRNA transport;GO:0051292,biological_process nuclear pore complex assembly;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat;GO:1990841,molecular_function promoter-specific chromatin binding	NUP98, ADAR2, NUP116; nuclear pore complex protein Nup98-Nup96; K14297	nucleoporin 98 [Source:HGNC Symbol%3BAcc:HGNC:8068]
ENSG00000130921	30.29	34.94	37.38	33.88	33.12	37.80	-0.0229707163055703	4.14149043128437	0.857587231579635	0.972078376915168	12:123232915-123257959:+	C12orf65	9;GO:0003747,molecular_function translation release factor activity;GO:0004045,molecular_function aminoacyl-tRNA hydrolase activity;GO:0005739,cellular_component mitochondrion;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0006412,biological_process translation;GO:0006415,biological_process translational termination;GO:0016150,molecular_function translation release factor activity, codon nonspecific;GO:0070126,biological_process mitochondrial translational termination;GO:0072344,biological_process rescue of stalled ribosome	NA	chromosome 12 open reading frame 65 [Source:HGNC Symbol%3BAcc:HGNC:26784]
ENSG00000162851	24.26	24.86	24.84	24.45	24.32	26.52	-0.0161221070899391	4.89356045908219	0.857867864880192	0.972279836027309	1:246540559-246566324:-	TFB2M	20;GO:0000154,biological_process rRNA modification;GO:0000179,molecular_function rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0003712,molecular_function transcription cofactor activity;GO:0003723,molecular_function RNA binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006390,biological_process transcription from mitochondrial promoter;GO:0006391,biological_process transcription initiation from mitochondrial promoter;GO:0007005,biological_process mitochondrion organization;GO:0008168,molecular_function methyltransferase activity;GO:0008649,molecular_function rRNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030054,cellular_component cell junction;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0042645,cellular_component mitochondrial nucleoid;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	transcription factor B2%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:18559]
ENSG00000165821	1.25	2.01	1.42	1.44	1.80	1.31	0.033201098628061	2.38028134269451	0.858020892414353	0.972279836027309	14:21521080-21537216:-	SALL2	20;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001654,biological_process eye development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007165,biological_process signal transduction;GO:0016581,cellular_component NuRD complex;GO:0021915,biological_process neural tube development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	spalt like transcription factor 2 [Source:HGNC Symbol%3BAcc:HGNC:10526]
ENSG00000159596	40.32	36.88	37.35	36.78	37.67	42.42	-0.0157139900038193	4.84727225117923	0.858108912117846	0.972279836027309	1:45687213-45694443:+	TMEM69	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 69 [Source:HGNC Symbol%3BAcc:HGNC:28035]
ENSG00000163378	14.90	15.40	13.68	13.87	15.62	14.30	0.0147988641692757	4.86720524602761	0.858382370984164	0.972279836027309	3:68975213-69013961:-	EOGT	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006493,biological_process protein O-linked glycosylation;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016262,molecular_function protein N-acetylglucosaminyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	EGF domain specific O-linked N-acetylglucosamine transferase [Source:HGNC Symbol%3BAcc:HGNC:28526]
ENSG00000063241	50.07	54.63	46.63	50.82	48.27	51.55	0.0124447257112913	5.06555805136633	0.858536740082721	0.972279836027309	19:55452984-55462343:-	ISOC2	6;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008152,biological_process metabolic process;GO:0031648,biological_process protein destabilization	NA	isochorismatase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26278]
ENSG00000128039	26.28	25.54	30.17	30.06	26.87	24.77	0.0210076345073054	4.71225168288264	0.858545305783089	0.972279836027309	4:55346108-55373096:+	SRD5A3	19;GO:0003865,molecular_function 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006486,biological_process protein glycosylation;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0006489,biological_process dolichyl diphosphate biosynthetic process;GO:0006629,biological_process lipid metabolic process;GO:0006702,biological_process androgen biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016095,biological_process polyprenol catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0016628,molecular_function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0019348,biological_process dolichol metabolic process;GO:0047751,molecular_function cholestenone 5-alpha-reductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0102389,molecular_function polyprenol reductase activity	SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]; K12345	steroid 5 alpha-reductase 3 [Source:HGNC Symbol%3BAcc:HGNC:25812]
ENSG00000138463	12.21	13.20	11.50	11.96	12.38	12.31	0.015705714646762	4.14610090409123	0.858564682625728	0.972279836027309	3:122794794-122881139:+	DIRC2	6;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	disrupted in renal carcinoma 2 [Source:HGNC Symbol%3BAcc:HGNC:16628]
ENSG00000106351	1.96	3.17	2.59	1.93	2.98	2.57	0.0390492793212016	1.94717174829314	0.858638056752021	0.972279836027309	7:100539210-100568219:+	AGFG2	6;GO:0003674,molecular_function molecular_function;GO:0005096,molecular_function GTPase activator activity;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	NA	ArfGAP with FG repeats 2 [Source:HGNC Symbol%3BAcc:HGNC:5177]
ENSG00000205352	110.08	128.49	114.72	124.37	121.18	106.59	0.0136240615077806	5.98262005414405	0.858842323119271	0.972279836027309	12:53441604-53446645:+	PRR13	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	proline rich 13 [Source:HGNC Symbol%3BAcc:HGNC:24528]
ENSG00000105176	64.51	64.30	64.46	63.55	62.24	67.51	0.0112774833426203	6.84362007810432	0.858865689117798	0.972279836027309	19:29923643-30016608:+	URI1	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001558,biological_process regulation of cell growth;GO:0003682,molecular_function chromatin binding;GO:0004864,molecular_function protein phosphatase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0009615,biological_process response to virus;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019212,molecular_function phosphatase inhibitor activity;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0051219,molecular_function phosphoprotein binding;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	NA	URI1%2C prefoldin like chaperone [Source:HGNC Symbol%3BAcc:HGNC:13236]
ENSG00000177946	10.20	9.37	13.64	11.08	11.36	12.03	-0.0316645069576457	2.70407083116858	0.858895598787884	0.972279836027309	16:89969790-89972534:-	CENPBD1	2;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	CENPB DNA-binding domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:28272]
ENSG00000080031	6.14	3.97	6.09	5.91	4.17	5.97	0.0332419639026893	4.1928032923069	0.858936271438905	0.972279836027309	19:55181247-55209506:-	PTPRH	19;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005902,cellular_component microvillus;GO:0006470,biological_process protein dephosphorylation;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0031528,cellular_component microvillus membrane;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042995,cellular_component cell projection	NA	protein tyrosine phosphatase%2C receptor type H [Source:HGNC Symbol%3BAcc:HGNC:9672]
ENSG00000112679	36.21	29.91	39.05	37.16	33.68	34.06	0.0239145841689662	4.56876155609383	0.858950755366164	0.972279836027309	6:291629-351355:+	DUSP22	21;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000188,biological_process inactivation of MAPK activity;GO:0002710,biological_process negative regulation of T cell mediated immunity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0006915,biological_process apoptotic process;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008283,biological_process cell proliferation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0046330,biological_process positive regulation of JNK cascade;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0050868,biological_process negative regulation of T cell activation	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 22 [Source:HGNC Symbol%3BAcc:HGNC:16077]
ENSG00000001497	20.63	20.92	18.51	20.00	21.58	19.53	-0.0148554642559056	5.58032566967668	0.858975552062692	0.972279836027309	X:65512581-65534775:-	LAS1L	13;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000470,biological_process maturation of LSU-rRNA;GO:0000478,biological_process endonucleolytic cleavage involved in rRNA processing;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006325,biological_process chromatin organization;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0071339,cellular_component MLL1 complex	NA	LAS1 like%2C ribosome biogenesis factor [Source:HGNC Symbol%3BAcc:HGNC:25726]
ENSG00000106367	185.72	206.05	185.10	198.87	195.15	192.15	-0.0132656320572198	6.8685359306148	0.859034322921808	0.972279836027309	7:101154396-101161596:+	AP1S1	25;GO:0000139,cellular_component Golgi membrane;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0008565,molecular_function protein transporter activity;GO:0009615,biological_process response to virus;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030117,cellular_component membrane coat;GO:0030121,cellular_component AP-1 adaptor complex;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032588,cellular_component trans-Golgi network membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043195,cellular_component terminal bouton;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0070062,cellular_component extracellular exosome	NA	adaptor related protein complex 1 sigma 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:559]
ENSG00000128886	2.43	2.69	1.84	2.34	2.13	2.25	0.0449718181879661	1.61096782986667	0.85907849138765	0.972279836027309	15:43772599-43777543:-	ELL3	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006354,biological_process DNA-templated transcription, elongation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0007283,biological_process spermatogenesis;GO:0008023,cellular_component transcription elongation factor complex;GO:0010717,biological_process regulation of epithelial to mesenchymal transition;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0035326,molecular_function enhancer binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048863,biological_process stem cell differentiation;GO:0050769,biological_process positive regulation of neurogenesis;GO:1901797,biological_process negative regulation of signal transduction by p53 class mediator;GO:1902166,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000179,biological_process positive regulation of neural precursor cell proliferation	NA	elongation factor for RNA polymerase II 3 [Source:HGNC Symbol%3BAcc:HGNC:23113]
ENSG00000185104	45.71	47.48	43.23	48.17	41.19	49.48	-0.014977524640902	6.56167843477508	0.859096531180821	0.972279836027309	1:50437027-50960263:-	FAF1	28;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007253,biological_process cytoplasmic sequestering of NF-kappaB;GO:0008219,biological_process cell death;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019887,molecular_function protein kinase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030155,biological_process regulation of cell adhesion;GO:0031072,molecular_function heat shock protein binding;GO:0031265,cellular_component CD95 death-inducing signaling complex;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034098,cellular_component VCP-NPL4-UFD1 AAA ATPase complex;GO:0042176,biological_process regulation of protein catabolic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045859,biological_process regulation of protein kinase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051059,molecular_function NF-kappaB binding;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	NA	Fas associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:3578]
ENSG00000197763	8.20	8.62	8.51	9.32	8.14	7.73	0.0193286052041802	4.03396485891972	0.859336273737687	0.97237977522503	3:126607051-126655155:-	TXNRD3	21;GO:0000305,biological_process response to oxygen radical;GO:0004791,molecular_function thioredoxin-disulfide reductase activity;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0009055,molecular_function electron carrier activity;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016668,molecular_function oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor;GO:0030154,biological_process cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045454,biological_process cell redox homeostasis;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process;GO:0098869,biological_process cellular oxidant detoxification	trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]; K00384	thioredoxin reductase 3 [Source:HGNC Symbol%3BAcc:HGNC:20667]
ENSG00000062598	12.68	12.23	13.52	13.20	13.03	12.17	0.016912661706186	4.97697466142005	0.859382685535566	0.97237977522503	20:46366048-46432985:-	ELMO2	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006909,biological_process phagocytosis;GO:0006915,biological_process apoptotic process;GO:0007010,biological_process cytoskeleton organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016477,biological_process cell migration;GO:0017124,molecular_function SH3 domain binding;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0060326,biological_process cell chemotaxis;GO:0098609,biological_process cell-cell adhesion	NA	engulfment and cell motility 2 [Source:HGNC Symbol%3BAcc:HGNC:17233]
ENSG00000163584	34.47	28.75	30.35	31.47	26.29	35.16	0.0251523300423518	3.98316129694703	0.859419843228374	0.97237977522503	3:170864874-170870483:-	RPL22L1	8;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	RP-L22e, RPL22; large subunit ribosomal protein L22e; K02891	ribosomal protein L22 like 1 [Source:HGNC Symbol%3BAcc:HGNC:27610]
ENSG00000134759	35.33	33.25	34.78	36.55	33.62	34.94	-0.0114200021706469	6.54098528395851	0.859591018048069	0.972484807421681	18:36129443-36180556:+	ELP2	13;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000993,molecular_function RNA polymerase II core binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008023,cellular_component transcription elongation factor complex;GO:0019901,molecular_function protein kinase binding;GO:0033588,cellular_component Elongator holoenzyme complex;GO:0046425,biological_process regulation of JAK-STAT cascade	NA	elongator acetyltransferase complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:18248]
ENSG00000171634	13.26	13.35	13.59	13.31	14.12	13.42	-0.0111787300966286	7.01195633776186	0.859847926938869	0.972686805531047	17:67825523-67984378:+	BPTF	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001892,biological_process embryonic placenta development;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007420,biological_process brain development;GO:0007492,biological_process endoderm development;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008134,molecular_function transcription factor binding;GO:0009611,biological_process response to wounding;GO:0009952,biological_process anterior/posterior pattern specification;GO:0016569,biological_process covalent chromatin modification;GO:0016589,cellular_component NURF complex;GO:0030425,cellular_component dendrite;GO:0043005,cellular_component neuron projection;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044297,cellular_component cell body;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048188,cellular_component Set1C/COMPASS complex;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:1990090,biological_process cellular response to nerve growth factor stimulus	NA	bromodomain PHD finger transcription factor [Source:HGNC Symbol%3BAcc:HGNC:3581]
ENSG00000110171	4.72	4.67	5.08	4.88	5.24	4.73	-0.0212234291099709	3.49473590651665	0.860126654160506	0.97274871660619	11:6448612-6474459:-	TRIM3	17;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0007399,biological_process nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0008270,molecular_function zinc ion binding;GO:0015031,biological_process protein transport;GO:0016567,biological_process protein ubiquitination;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	tripartite motif containing 3 [Source:HGNC Symbol%3BAcc:HGNC:10064]
ENSG00000106299	32.49	32.86	33.04	35.09	33.54	31.47	-0.0126988913298853	5.65231731792332	0.860155647103481	0.97274871660619	7:123681934-123749067:-	WASL	40;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006461,biological_process protein complex assembly;GO:0006900,biological_process membrane budding;GO:0006928,biological_process movement of cell or subcellular component;GO:0007015,biological_process actin filament organization;GO:0007049,biological_process cell cycle;GO:0008154,biological_process actin polymerization or depolymerization;GO:0009617,biological_process response to bacterium;GO:0015629,cellular_component actin cytoskeleton;GO:0016050,biological_process vesicle organization;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030050,biological_process vesicle transport along actin filament;GO:0030478,cellular_component actin cap;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030695,molecular_function GTPase regulator activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032880,biological_process regulation of protein localization;GO:0034629,biological_process cellular protein complex localization;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051301,biological_process cell division;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051653,biological_process spindle localization;GO:0060997,biological_process dendritic spine morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:1903526,biological_process negative regulation of membrane tubulation;GO:2000370,biological_process positive regulation of clathrin-mediated endocytosis;GO:2000402,biological_process negative regulation of lymphocyte migration;GO:2000601,biological_process positive regulation of Arp2/3 complex-mediated actin nucleation	WAS; Wiskott-Aldrich syndrome protein; K05747	Wiskott-Aldrich syndrome like [Source:HGNC Symbol%3BAcc:HGNC:12735]
ENSG00000117620	4.12	4.52	5.45	4.26	5.10	4.53	0.034279676785231	2.79812277835663	0.860191646951588	0.97274871660619	1:99969350-100035637:+	SLC35A3	13;GO:0000139,cellular_component Golgi membrane;GO:0005351,molecular_function sugar:proton symporter activity;GO:0005462,molecular_function UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0006047,biological_process UDP-N-acetylglucosamine metabolic process;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015788,biological_process UDP-N-acetylglucosamine transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1990569,biological_process UDP-N-acetylglucosamine transmembrane transport	NA	solute carrier family 35 member A3 [Source:HGNC Symbol%3BAcc:HGNC:11023]
ENSG00000167081	17.25	15.15	18.93	16.95	18.53	15.72	0.0230006133993449	4.59320543068169	0.860254554799348	0.97274871660619	9:125747344-125967377:+	PBX3	19;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007387,biological_process anterior compartment pattern formation;GO:0007388,biological_process posterior compartment specification;GO:0007585,biological_process respiratory gaseous exchange;GO:0008344,biological_process adult locomotory behavior;GO:0021516,biological_process dorsal spinal cord development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048666,biological_process neuron development	PBX3; pre-B-cell leukemia transcription factor 3; K15610	PBX homeobox 3 [Source:HGNC Symbol%3BAcc:HGNC:8634]
ENSG00000117569	11.44	11.21	11.10	10.88	12.19	11.39	-0.0172277917323318	4.20795806553553	0.860294482470213	0.97274871660619	1:96721664-96823738:+	PTBP2	15;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0021510,biological_process spinal cord development;GO:0021549,biological_process cerebellum development;GO:0030426,cellular_component growth cone;GO:0033119,biological_process negative regulation of RNA splicing;GO:0036002,molecular_function pre-mRNA binding;GO:0043025,cellular_component neuronal cell body;GO:2000177,biological_process regulation of neural precursor cell proliferation	NA	polypyrimidine tract binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17662]
ENSG00000184056	13.39	10.12	11.09	12.38	12.01	11.09	-0.0154143209243406	4.44967916100898	0.860585761697749	0.972801404068055	15:90998415-91022603:-	VPS33B	35;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0007032,biological_process endosome organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017185,biological_process peptidyl-lysine hydroxylation;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030199,biological_process collagen fibril organization;GO:0030897,cellular_component HOPS complex;GO:0031091,cellular_component platelet alpha granule;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0032400,biological_process melanosome localization;GO:0032418,biological_process lysosome localization;GO:0032963,biological_process collagen metabolic process;GO:0035855,biological_process megakaryocyte development;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0061025,biological_process membrane fusion;GO:0070889,biological_process platelet alpha granule organization;GO:0071439,cellular_component clathrin complex;GO:0090330,biological_process regulation of platelet aggregation	NA	VPS33B%2C late endosome and lysosome associated [Source:HGNC Symbol%3BAcc:HGNC:12712]
ENSG00000185480	6.45	7.46	6.25	5.99	7.67	6.25	0.0234170752828036	3.77700075442551	0.860625559813011	0.972801404068055	12:102120184-102197520:+	PARPBP	9;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination	NA	PARP1 binding protein [Source:HGNC Symbol%3BAcc:HGNC:26074]
ENSG00000156966	3.52	2.94	4.34	3.36	3.59	4.33	-0.0382812107222984	2.20715004164655	0.860640247660011	0.972801404068055	2:231395542-231401164:+	B3GNT7	12;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006486,biological_process protein glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0008499,molecular_function UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0008532,molecular_function N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018146,biological_process keratan sulfate biosynthetic process	B3GNT7; beta-1,3-N-acetylglucosaminyltransferase 7 [EC:2.4.1.-]; K09664	UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:18811]
ENSG00000128346	18.33	16.15	20.12	20.24	17.01	17.07	0.0282350708962369	3.58611146593055	0.860656640119042	0.972801404068055	22:37943049-37953669:-	C22orf23	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	chromosome 22 open reading frame 23 [Source:HGNC Symbol%3BAcc:HGNC:18589]
ENSG00000140534	2.63	3.44	2.66	2.94	2.78	2.90	0.0164750052889872	4.05587687868411	0.86073292684117	0.972801404068055	15:89575481-89631056:+	TICRR	13;GO:0000075,biological_process cell cycle checkpoint;GO:0001731,biological_process formation of translation preinitiation complex;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0010212,biological_process response to ionizing radiation;GO:0030174,biological_process regulation of DNA-dependent DNA replication initiation;GO:0033314,biological_process mitotic DNA replication checkpoint	NA	TOPBP1 interacting checkpoint and replication regulator [Source:HGNC Symbol%3BAcc:HGNC:28704]
ENSG00000225973	49.70	53.68	48.16	51.30	52.43	46.01	0.0245331382873617	3.04734879233773	0.860911440999611	0.972894992742875	15:55317183-55319161:-	PIGBOS1	1;GO:0005576,cellular_component extracellular region	NA	PIGB opposite strand 1 [Source:HGNC Symbol%3BAcc:HGNC:50696]
ENSG00000215784	5.69	4.49	7.41	5.36	5.94	7.24	-0.047336225807604	1.52232150514613	0.860972488139893	0.972894992742875	1:145095999-145112696:+	FAM72D	2;GO:0005829,cellular_component cytosol;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	family with sequence similarity 72 member D [Source:HGNC Symbol%3BAcc:HGNC:33593]
ENSG00000148688	20.37	23.71	19.46	21.02	18.67	23.33	0.0151833871270739	4.46274872108656	0.861113538065149	0.972906016258984	10:90871715-90908553:+	RPP30	17;GO:0000172,cellular_component ribonuclease MRP complex;GO:0001682,biological_process tRNA 5'-leader removal;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004526,molecular_function ribonuclease P activity;GO:0004540,molecular_function ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005655,cellular_component nucleolar ribonuclease P complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0030681,cellular_component multimeric ribonuclease P complex;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	RPP1, RPP30; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]; K03539	ribonuclease P/MRP subunit p30 [Source:HGNC Symbol%3BAcc:HGNC:17688]
ENSG00000106537	102.13	111.96	101.74	111.70	100.13	103.41	0.0116027308846731	6.01136343680488	0.861138999487429	0.972906016258984	7:16753534-16784536:+	TSPAN13	8;GO:0005246,molecular_function calcium channel regulator activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0065009,biological_process regulation of molecular function;GO:1903169,biological_process regulation of calcium ion transmembrane transport	NA	tetraspanin 13 [Source:HGNC Symbol%3BAcc:HGNC:21643]
ENSG00000185883	95.84	112.01	110.01	105.46	117.60	100.56	-0.016384783549911	5.63913490794867	0.861786953496314	0.97325441582288	16:2513869-2520218:+	ATP6V0C	34;GO:0000220,cellular_component vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005773,cellular_component vacuole;GO:0005774,cellular_component vacuolar membrane;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007042,biological_process lysosomal lumen acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016241,biological_process regulation of macroautophagy;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033177,cellular_component proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0035577,cellular_component azurophil granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0090383,biological_process phagosome acidification;GO:0101003,cellular_component ficolin-1-rich granule membrane	ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit; K02155	ATPase H+ transporting V0 subunit c [Source:HGNC Symbol%3BAcc:HGNC:855]
ENSG00000156011	5.99	4.94	6.47	5.78	5.36	6.20	0.0233936300448845	4.48816509764281	0.861841976040026	0.97325441582288	8:18527300-19084730:-	PSD3	13;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005086,molecular_function ARF guanyl-nucleotide exchange factor activity;GO:0005543,molecular_function phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0032012,biological_process regulation of ARF protein signal transduction;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	PSD; PH and SEC7 domain-containing protein; K12494	pleckstrin and Sec7 domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:19093]
ENSG00000151502	16.19	16.14	17.98	16.67	15.81	17.65	0.0182740819677811	4.16392005176991	0.861874452088473	0.97325441582288	11:134224644-134247792:+	VPS26B	16;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0030904,cellular_component retromer complex;GO:0030906,cellular_component retromer, cargo-selective complex;GO:0042147,biological_process retrograde transport, endosome to Golgi	NA	VPS26%2C retromer complex component B [Source:HGNC Symbol%3BAcc:HGNC:28119]
ENSG00000023445	31.13	35.76	33.74	32.77	34.88	34.60	-0.0146094906230312	6.03486770342371	0.862050785931318	0.97325441582288	11:102317449-102339403:+	BIRC3	35;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007283,biological_process spermatogenesis;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034121,biological_process regulation of toll-like receptor signaling pathway;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0039535,biological_process regulation of RIG-I signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0045088,biological_process regulation of innate immune response;GO:0045121,cellular_component membrane raft;GO:0046872,molecular_function metal ion binding;GO:0050727,biological_process regulation of inflammatory response;GO:0051291,biological_process protein heterooligomerization;GO:0060544,biological_process regulation of necroptotic process;GO:0060546,biological_process negative regulation of necroptotic process;GO:0070424,biological_process regulation of nucleotide-binding oligomerization domain containing signaling pathway;GO:1990001,biological_process inhibition of cysteine-type endopeptidase activity involved in apoptotic process;GO:2000116,biological_process regulation of cysteine-type endopeptidase activity	BIRC2_3; baculoviral IAP repeat-containing protein 2/3; K16060	baculoviral IAP repeat containing 3 [Source:HGNC Symbol%3BAcc:HGNC:591]
ENSG00000007944	12.17	12.96	13.62	12.84	13.75	11.96	0.0193845369106058	4.11627745857575	0.862080711101659	0.97325441582288	6:16129124-16148248:+	MYLIP	23;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006928,biological_process movement of cell or subcellular component;GO:0007399,biological_process nervous system development;GO:0008092,molecular_function cytoskeletal protein binding;GO:0010989,biological_process negative regulation of low-density lipoprotein particle clearance;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031648,biological_process protein destabilization;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0032803,biological_process regulation of low-density lipoprotein particle receptor catabolic process;GO:0042632,biological_process cholesterol homeostasis;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	MYLIP, MIR; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]; K10637	myosin regulatory light chain interacting protein [Source:HGNC Symbol%3BAcc:HGNC:21155]
ENSG00000055211	84.46	82.25	77.76	80.42	84.12	79.91	0.011806211399712	6.3888781420001	0.862163431195043	0.97325441582288	6:149566293-149591748:+	GINM1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	glycoprotein integral membrane 1 [Source:HGNC Symbol%3BAcc:HGNC:21074]
ENSG00000113580	39.93	40.57	41.95	42.33	37.97	42.12	0.0119653489461695	6.60457305462091	0.862352028826004	0.97325441582288	5:143277930-143435512:-	NR3C1	46;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003723,molecular_function RNA binding;GO:0004883,molecular_function glucocorticoid receptor activity;GO:0005496,molecular_function steroid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0008289,molecular_function lipid binding;GO:0016569,biological_process covalent chromatin modification;GO:0032183,molecular_function SUMO binding;GO:0038051,molecular_function glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity;GO:0042921,biological_process glucocorticoid receptor signaling pathway;GO:0043234,cellular_component protein complex;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043402,biological_process glucocorticoid mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:0051879,molecular_function Hsp90 protein binding;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:1990239,molecular_function steroid hormone binding	NR3C1, GR; glucocorticoid receptor; K05771	nuclear receptor subfamily 3 group C member 1 [Source:HGNC Symbol%3BAcc:HGNC:7978]
ENSG00000165416	25.99	26.79	24.47	26.05	27.01	25.56	-0.0161481706247161	4.83752066154557	0.862379610692217	0.97325441582288	13:52652708-52700909:+	SUGT1	10;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000278,biological_process mitotic cell cycle;GO:0000776,cellular_component kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0031647,biological_process regulation of protein stability;GO:0043234,cellular_component protein complex;GO:0043947,biological_process positive regulation by host of symbiont catalytic activity	SUGT1, SGT1; suppressor of G2 allele of SKP1; K12795	SGT1 homolog%2C MIS12 kinetochore complex assembly cochaperone [Source:HGNC Symbol%3BAcc:HGNC:16987]
ENSG00000158717	9.88	8.02	9.63	9.65	8.18	10.54	-0.0235758883582013	3.25294539342611	0.862463508356223	0.97325441582288	16:88696494-88706421:-	RNF166	6;GO:0000209,biological_process protein polyubiquitination;GO:0005622,cellular_component intracellular;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 166 [Source:HGNC Symbol%3BAcc:HGNC:28856]
ENSG00000143776	10.19	10.21	10.75	10.53	10.49	10.63	-0.0113670324562883	5.8803200166496	0.862567858280717	0.97325441582288	1:226989864-227318474:-	CDC42BPA	23;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005911,cellular_component cell-cell junction;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0031032,biological_process actomyosin structure organization;GO:0031252,cellular_component cell leading edge;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0035556,biological_process intracellular signal transduction;GO:0042641,cellular_component actomyosin;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	CDC42 binding protein kinase alpha [Source:HGNC Symbol%3BAcc:HGNC:1737]
ENSG00000129422	9.01	8.78	7.78	8.50	8.23	8.77	0.0135506109276878	5.16682191486131	0.862572366637112	0.97325441582288	8:17643794-17800917:-	MTUS1	13;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane	NA	microtubule associated scaffold protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29789]
ENSG00000146731	255.86	277.76	258.18	266.07	276.42	261.72	-0.0110863191096424	8.72835285399857	0.862646627607477	0.97325441582288	7:56051629-56063989:+	CCT6A	21;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0031012,cellular_component extracellular matrix;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0044183,molecular_function protein binding involved in protein folding;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0071987,molecular_function WD40-repeat domain binding;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	chaperonin containing TCP1 subunit 6A [Source:HGNC Symbol%3BAcc:HGNC:1620]
ENSG00000102053	0.73	0.95	1.79	1.04	1.36	0.95	0.069307812476386	1.59209135920991	0.862686751163322	0.97325441582288	X:65366637-65507887:+	ZC3H12B	5;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	zinc finger CCCH-type containing 12B [Source:HGNC Symbol%3BAcc:HGNC:17407]
ENSG00000117360	33.95	34.09	33.19	33.11	34.28	33.87	0.0109556036502455	6.11550915938695	0.862835179739197	0.97325441582288	1:150321475-150353195:+	PRPF3	16;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0046540,cellular_component U4/U6 x U5 tri-snRNP complex	NA	pre-mRNA processing factor 3 [Source:HGNC Symbol%3BAcc:HGNC:17348]
ENSG00000075303	35.11	33.37	36.08	35.76	32.31	36.39	0.0149889067868573	5.17075366227521	0.862848816186266	0.97325441582288	7:87833567-87876357:-	SLC25A40	8;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022857,molecular_function transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 25 member 40 [Source:HGNC Symbol%3BAcc:HGNC:29680]
ENSG00000125912	23.53	24.71	20.56	22.43	24.08	23.47	-0.0168072988260503	5.32620715225817	0.862862799937229	0.97325441582288	19:3185562-3209575:+	NCLN	8;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031648,biological_process protein destabilization;GO:0043254,biological_process regulation of protein complex assembly	NA	nicalin [Source:HGNC Symbol%3BAcc:HGNC:26923]
ENSG00000167658	1019.32	976.07	1048.60	1043.47	978.56	1025.17	0.0102627635936114	11.4322183171571	0.862866901287059	0.97325441582288	19:3976055-3985469:-	EEF2	47;GO:0000166,molecular_function nucleotide binding;GO:0002039,molecular_function p53 binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002931,biological_process response to ischemia;GO:0003009,biological_process skeletal muscle contraction;GO:0003723,molecular_function RNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0006479,biological_process protein methylation;GO:0007568,biological_process aging;GO:0008097,molecular_function 5S rRNA binding;GO:0014009,biological_process glial cell proliferation;GO:0016020,cellular_component membrane;GO:0016235,cellular_component aggresome;GO:0017183,biological_process peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0019901,molecular_function protein kinase binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0032355,biological_process response to estradiol;GO:0034774,cellular_component secretory granule lumen;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042788,cellular_component polysomal ribosome;GO:0043022,molecular_function ribosome binding;GO:0043312,biological_process neutrophil degranulation;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0045471,biological_process response to ethanol;GO:0045727,biological_process positive regulation of translation;GO:0051015,molecular_function actin filament binding;GO:0051593,biological_process response to folic acid;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:1990416,biological_process cellular response to brain-derived neurotrophic factor stimulus;GO:2000767,biological_process positive regulation of cytoplasmic translation	EEF2; elongation factor 2; K03234	eukaryotic translation elongation factor 2 [Source:HGNC Symbol%3BAcc:HGNC:3214]
ENSG00000113719	143.94	137.11	144.23	153.88	130.98	147.64	-0.0121679044159735	7.52482753256188	0.862979977307175	0.97325441582288	5:172834274-172952685:+	ERGIC1	14;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	endoplasmic reticulum-golgi intermediate compartment 1 [Source:HGNC Symbol%3BAcc:HGNC:29205]
ENSG00000151276	4.94	4.60	5.50	5.39	5.24	4.75	-0.0145075749269813	4.59754121437887	0.863049875083009	0.97325441582288	3:65353524-66038834:-	MAGI1	20;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005923,cellular_component bicellular tight junction;GO:0006461,biological_process protein complex assembly;GO:0007155,biological_process cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0032947,molecular_function protein complex scaffold;GO:0042995,cellular_component cell projection;GO:0051393,molecular_function alpha-actinin binding;GO:0070997,biological_process neuron death	AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1); K05631	membrane associated guanylate kinase%2C WW and PDZ domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:946]
ENSG00000204381	0.86	1.41	1.34	1.30	1.06	1.47	-0.0954569814620616	0.651802423509846	0.863087817852161	0.97325441582288	11:111540279-111561745:+	LAYN	7;GO:0001726,cellular_component ruffle;GO:0005540,molecular_function hyaluronic acid binding;GO:0005925,cellular_component focal adhesion;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding	NA	layilin [Source:HGNC Symbol%3BAcc:HGNC:29471]
ENSG00000121691	148.53	147.01	148.04	146.29	154.80	149.35	-0.0102626665225217	7.88193520126957	0.863093902310341	0.97325441582288	11:34438924-34472062:+	CAT	75;GO:0000302,biological_process response to reactive oxygen species;GO:0001649,biological_process osteoblast differentiation;GO:0001657,biological_process ureteric bud development;GO:0001666,biological_process response to hypoxia;GO:0001822,biological_process kidney development;GO:0004046,molecular_function aminoacylase activity;GO:0004096,molecular_function catalase activity;GO:0004601,molecular_function peroxidase activity;GO:0005102,molecular_function receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005764,cellular_component lysosome;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006641,biological_process triglyceride metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0007568,biological_process aging;GO:0008203,biological_process cholesterol metabolic process;GO:0009060,biological_process aerobic respiration;GO:0009314,biological_process response to radiation;GO:0009411,biological_process response to UV;GO:0009636,biological_process response to toxic substance;GO:0009642,biological_process response to light intensity;GO:0009650,biological_process UV protection;GO:0010193,biological_process response to ozone;GO:0010288,biological_process response to lead ion;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823,biological_process response to activity;GO:0014854,biological_process response to inactivity;GO:0016020,cellular_component membrane;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016684,molecular_function oxidoreductase activity, acting on peroxide as acceptor;GO:0019899,molecular_function enzyme binding;GO:0020027,biological_process hemoglobin metabolic process;GO:0020037,molecular_function heme binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032355,biological_process response to estradiol;GO:0032868,biological_process response to insulin;GO:0033189,biological_process response to vitamin A;GO:0033197,biological_process response to vitamin E;GO:0033591,biological_process response to L-ascorbic acid;GO:0034599,biological_process cellular response to oxidative stress;GO:0034774,cellular_component secretory granule lumen;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045471,biological_process response to ethanol;GO:0046686,biological_process response to cadmium ion;GO:0046872,molecular_function metal ion binding;GO:0050661,molecular_function NADP binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051262,biological_process protein tetramerization;GO:0051289,biological_process protein homotetramerization;GO:0051781,biological_process positive regulation of cell division;GO:0055093,biological_process response to hyperoxia;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070542,biological_process response to fatty acid;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0080184,biological_process response to phenylpropanoid;GO:0098869,biological_process cellular oxidant detoxification;GO:1904813,cellular_component ficolin-1-rich granule lumen	katE, CAT, catB, srpA; catalase [EC:1.11.1.6]; K03781	catalase [Source:HGNC Symbol%3BAcc:HGNC:1516]
ENSG00000133805	8.23	8.38	7.84	8.85	7.35	8.11	0.0179748551525608	4.35350430481456	0.863295450291716	0.973393262282775	11:10308312-10507579:+	AMPD3	22;GO:0003876,molecular_function AMP deaminase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0006188,biological_process IMP biosynthetic process;GO:0006196,biological_process AMP catabolic process;GO:0009117,biological_process nucleotide metabolic process;GO:0009168,biological_process purine ribonucleoside monophosphate biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0019239,molecular_function deaminase activity;GO:0032264,biological_process IMP salvage;GO:0034101,biological_process erythrocyte homeostasis;GO:0034774,cellular_component secretory granule lumen;GO:0043101,biological_process purine-containing compound salvage;GO:0043312,biological_process neutrophil degranulation;GO:0046031,biological_process ADP metabolic process;GO:0046033,biological_process AMP metabolic process;GO:0046034,biological_process ATP metabolic process;GO:0046039,biological_process GTP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0097009,biological_process energy homeostasis;GO:1904813,cellular_component ficolin-1-rich granule lumen	AMPD; AMP deaminase [EC:3.5.4.6]; K01490	adenosine monophosphate deaminase 3 [Source:HGNC Symbol%3BAcc:HGNC:470]
ENSG00000133863	0.10	0.30	0.25	0.20	0.21	0.27	-0.0946089849808917	1.16641609464006	0.863429685071877	0.973456192624633	8:30831543-30890606:-	TEX15	16;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007129,biological_process synapsis;GO:0007130,biological_process synaptonemal complex assembly;GO:0007140,biological_process male meiosis;GO:0007283,biological_process spermatogenesis;GO:0009566,biological_process fertilization;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0030154,biological_process cell differentiation;GO:0030539,biological_process male genitalia development;GO:0032880,biological_process regulation of protein localization;GO:0034502,biological_process protein localization to chromosome;GO:0048873,biological_process homeostasis of number of cells within a tissue;GO:0051321,biological_process meiotic cell cycle	NA	testis expressed 15%2C meiosis and synapsis associated [Source:HGNC Symbol%3BAcc:HGNC:11738]
ENSG00000164815	19.17	16.07	19.31	16.56	18.26	19.63	0.0206430361566922	4.71566495172823	0.863571823850395	0.973459195561939	7:104126340-104208047:-	ORC5	14;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000808,cellular_component origin recognition complex;GO:0003674,molecular_function molecular_function;GO:0003688,molecular_function DNA replication origin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005664,cellular_component nuclear origin of replication recognition complex;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation	ORC5; origin recognition complex subunit 5; K02607	origin recognition complex subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:8491]
ENSG00000104093	5.58	5.26	5.40	5.71	5.43	5.38	-0.0111462267542781	5.65265071984816	0.863589193710471	0.973459195561939	15:51447710-51622833:-	DMXL2	11;GO:0005615,cellular_component extracellular space;GO:0007035,biological_process vacuolar acidification;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030054,cellular_component cell junction;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043291,cellular_component RAVE complex;GO:0045202,cellular_component synapse;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly	NA	Dmx like 2 [Source:HGNC Symbol%3BAcc:HGNC:2938]
ENSG00000135074	13.81	10.21	14.59	14.51	10.34	13.49	0.0255219506628425	5.26694825875121	0.863731058030057	0.973520064676202	5:157395533-157575775:-	ADAM19	14;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007507,biological_process heart development;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030198,biological_process extracellular matrix organization;GO:0046872,molecular_function metal ion binding	NA	ADAM metallopeptidase domain 19 [Source:HGNC Symbol%3BAcc:HGNC:197]
ENSG00000157191	36.89	39.37	37.25	34.94	38.84	39.43	0.0121332690012328	5.22799479581449	0.863819401554705	0.973520064676202	1:16440671-16460078:+	NECAP2	10;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030125,cellular_component clathrin vesicle coat;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle	NA	NECAP endocytosis associated 2 [Source:HGNC Symbol%3BAcc:HGNC:25528]
ENSG00000144476	3.71	2.11	4.61	4.41	2.10	3.69	0.0594501228599214	1.97978395243281	0.863908207249645	0.973520064676202	2:236567786-236582358:+	ACKR3	33;GO:0001525,biological_process angiogenesis;GO:0001570,biological_process vasculogenesis;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0009986,cellular_component cell surface;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016494,molecular_function C-X-C chemokine receptor activity;GO:0019956,molecular_function chemokine binding;GO:0019958,molecular_function C-X-C chemokine binding;GO:0031623,biological_process receptor internalization;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1905322,biological_process positive regulation of mesenchymal stem cell migration	CXCR7, ACKR3, RDC1; C-X-C chemokine receptor type 7 (atypical chemokine receptor 3); K04304	atypical chemokine receptor 3 [Source:HGNC Symbol%3BAcc:HGNC:23692]
ENSG00000267697	478.14	483.32	496.17	493.55	472.05	515.67	-0.0117373613056254	6.41693888332061	0.863956902640219	0.973520064676202	7:135927273-135927450:-	LUZP6	NA	NA	leucine zipper protein 6 [Source:HGNC Symbol%3BAcc:HGNC:33955]
ENSG00000173171	12.45	12.94	12.77	12.99	11.45	13.54	0.0154146490314715	4.18210277161949	0.864290385544943	0.973789744462643	1:155208698-155213824:+	MTX1	7;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	metaxin 1 [Source:HGNC Symbol%3BAcc:HGNC:7504]
ENSG00000151116	15.68	17.05	14.86	15.07	17.31	14.93	0.0163783840630826	4.52262477857331	0.864420730559972	0.973789744462643	11:18529608-18588747:-	UEVLD	11;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005975,biological_process carbohydrate metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0008150,biological_process biological_process;GO:0015031,biological_process protein transport;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019752,biological_process carboxylic acid metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	NA	UEV and lactate/malate dehyrogenase domains [Source:HGNC Symbol%3BAcc:HGNC:30866]
ENSG00000100307	4.03	4.57	4.30	4.37	3.42	4.67	0.0498214728822632	1.73638623932054	0.864431579330852	0.973789744462643	22:39120166-39152674:-	CBX7	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex	NA	chromobox 7 [Source:HGNC Symbol%3BAcc:HGNC:1557]
ENSG00000262576	0.19	0.36	0.43	0.18	0.13	0.60	0.0918036948818191	0.106328530740692	0.864744565606429	0.973888364674556	5:141355024-141512979:+	PCDHGA4	7;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	protocadherin gamma subfamily A%2C 4 [Source:HGNC Symbol%3BAcc:HGNC:8702]
ENSG00000167136	20.77	20.06	22.39	18.65	20.60	23.68	0.0192645345112938	4.24231145599411	0.86488072939368	0.973888364674556	9:128818473-128822677:+	ENDOG	27;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004536,molecular_function deoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006310,biological_process DNA recombination;GO:0007568,biological_process aging;GO:0009612,biological_process response to mechanical stimulus;GO:0016787,molecular_function hydrolase activity;GO:0032355,biological_process response to estradiol;GO:0034599,biological_process cellular response to oxidative stress;GO:0034612,biological_process response to tumor necrosis factor;GO:0036475,biological_process neuron death in response to oxidative stress;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043204,cellular_component perikaryon;GO:0046677,biological_process response to antibiotic;GO:0046872,molecular_function metal ion binding;GO:0071277,biological_process cellular response to calcium ion;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:1901300,biological_process positive regulation of hydrogen peroxide-mediated programmed cell death;GO:1902512,biological_process positive regulation of apoptotic DNA fragmentation	ENDOG; endonuclease G, mitochondrial; K01173	endonuclease G [Source:HGNC Symbol%3BAcc:HGNC:3346]
ENSG00000175727	16.53	15.60	16.99	16.70	16.34	16.94	-0.0107746067107322	5.7207125869147	0.864893331356379	0.973888364674556	12:122078721-122147347:+	MLXIP	16;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000989,molecular_function transcription factor activity, transcription factor binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:1900402,biological_process regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter	MLX; MAX-like protein X; K09113	MLX interacting protein [Source:HGNC Symbol%3BAcc:HGNC:17055]
ENSG00000163803	0.32	0.29	0.30	0.29	0.26	0.43	-0.0927856885069667	0.696627361757454	0.865086786729303	0.973888364674556	2:28457144-28643788:+	PLB1	16;GO:0001523,biological_process retinoid metabolic process;GO:0004622,molecular_function lysophospholipase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016298,molecular_function lipase activity;GO:0016324,cellular_component apical plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0042572,biological_process retinol metabolic process;GO:0050253,molecular_function retinyl-palmitate esterase activity;GO:2000344,biological_process positive regulation of acrosome reaction	PLB1, PLB; phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5]; K14621	phospholipase B1 [Source:HGNC Symbol%3BAcc:HGNC:30041]
ENSG00000152944	19.68	23.86	18.88	19.93	23.01	20.76	-0.0276799145981356	3.93893208998192	0.865114064804821	0.973888364674556	12:27022545-27066343:+	MED21	15;GO:0000151,cellular_component ubiquitin ligase complex;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001824,biological_process blastocyst development;GO:0003713,molecular_function transcription coactivator activity;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	mediator complex subunit 21 [Source:HGNC Symbol%3BAcc:HGNC:11473]
ENSG00000197111	295.49	285.10	290.24	291.78	288.74	291.65	0.00969798464861196	8.93232789122256	0.865117658291352	0.973888364674556	12:53452101-53481162:+	PCBP2	25;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0016071,biological_process mRNA metabolic process;GO:0019899,molecular_function enzyme binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032480,biological_process negative regulation of type I interferon production;GO:0039694,biological_process viral RNA genome replication;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045087,biological_process innate immune response;GO:0050687,biological_process negative regulation of defense response to virus;GO:0051607,biological_process defense response to virus;GO:0070062,cellular_component extracellular exosome;GO:0075522,biological_process IRES-dependent viral translational initiation	PCBP2; poly(rC)-binding protein 2; K13162	poly(rC) binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:8648]
ENSG00000169592	79.94	82.37	81.47	88.19	74.05	85.71	-0.0137906051483617	6.0462377504596	0.865144554559714	0.973888364674556	16:29995293-30005793:+	INO80E	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016579,biological_process protein deubiquitination;GO:0031011,cellular_component Ino80 complex	NA	INO80 complex subunit E [Source:HGNC Symbol%3BAcc:HGNC:26905]
ENSG00000160131	21.01	19.99	24.16	23.86	18.63	24.43	-0.0235793411955098	3.54395409298301	0.86514678137971	0.973888364674556	X:151396514-151409364:+	VMA21	10;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0043462,biological_process regulation of ATPase activity;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly	NA	VMA21%2C vacuolar ATPase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:22082]
ENSG00000173137	7.87	8.35	8.58	8.58	8.53	8.20	-0.0185219584762543	4.01073785380079	0.865230639975511	0.973894444506349	8:144373100-144393242:+	ADCK5	8;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	aarF domain containing kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:21738]
ENSG00000066923	2.35	2.28	2.25	2.51	2.19	2.11	0.0267279315298127	3.11541827950806	0.865385098279329	0.973912378582071	7:100177562-100221488:+	STAG3	17;GO:0000775,cellular_component chromosome, centromeric region;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000795,cellular_component synaptonemal complex;GO:0000800,cellular_component lateral element;GO:0000802,cellular_component transverse filament;GO:0001673,cellular_component male germ cell nucleus;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007129,biological_process synapsis;GO:0007130,biological_process synaptonemal complex assembly;GO:0030893,cellular_component meiotic cohesin complex;GO:0034502,biological_process protein localization to chromosome;GO:0034991,cellular_component nuclear meiotic cohesin complex;GO:0051321,biological_process meiotic cell cycle	STAG3; cohesin complex subunit SA-3; K13055	stromal antigen 3 [Source:HGNC Symbol%3BAcc:HGNC:11356]
ENSG00000275793	0.22	0.25	0.37	0.18	0.29	0.33	0.0780602822949625	0.591800682353366	0.865403491159288	0.973912378582071	22:18605814-18611919:-	RIMBP3	1;GO:0005515,molecular_function protein binding	NA	RIMS binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:29344]
ENSG00000092203	39.58	40.94	39.11	40.74	39.97	38.92	0.0106197514776163	6.347700845503	0.865533870813659	0.973929544654004	14:21476596-21499175:+	TOX4	6;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0072357,cellular_component PTW/PP1 phosphatase complex	NA	TOX high mobility group box family member 4 [Source:HGNC Symbol%3BAcc:HGNC:20161]
ENSG00000081026	3.68	3.89	3.37	4.08	3.62	3.47	-0.0217365199903625	4.08383376448721	0.865627805320199	0.973929544654004	1:113390748-113685923:+	MAGI3	20;GO:0000166,molecular_function nucleotide binding;GO:0004385,molecular_function guanylate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0030054,cellular_component cell junction;GO:0032947,molecular_function protein complex scaffold;GO:0035556,biological_process intracellular signal transduction;GO:0046037,biological_process GMP metabolic process;GO:0046328,biological_process regulation of JNK cascade;GO:0046710,biological_process GDP metabolic process	MAGI3; membrane-associated guanylate kinase-related; K06112	membrane associated guanylate kinase%2C WW and PDZ domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:29647]
ENSG00000079999	21.35	24.31	20.97	20.68	23.51	22.22	0.0118749855018356	5.60483182975138	0.865654126010443	0.973929544654004	19:10486119-10503741:-	KEAP1	27;GO:0001701,biological_process in utero embryonic development;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0010499,biological_process proteasomal ubiquitin-independent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0030496,cellular_component midbody;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0043234,cellular_component protein complex;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043687,biological_process post-translational protein modification;GO:0045604,biological_process regulation of epidermal cell differentiation;GO:0071353,biological_process cellular response to interleukin-4;GO:0097718,molecular_function disordered domain specific binding	KLHL19, KEAP1, INRF2; kelch-like protein 19; K10456	kelch like ECH associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:23177]
ENSG00000104518	36.31	33.48	34.90	35.54	31.67	37.44	0.0134003912380066	5.9790533260177	0.866169362488523	0.97441459136364	8:143553206-143563062:+	GSDMD	32;GO:0001786,molecular_function phosphatidylserine binding;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0019835,biological_process cytolysis;GO:0031668,biological_process cellular response to extracellular stimulus;GO:0035580,cellular_component specific granule lumen;GO:0035915,biological_process pore formation in membrane of other organism;GO:0043312,biological_process neutrophil degranulation;GO:0045087,biological_process innate immune response;GO:0046931,biological_process pore complex assembly;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051260,biological_process protein homooligomerization;GO:0061702,cellular_component inflammasome complex;GO:0070269,biological_process pyroptosis;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0070300,molecular_function phosphatidic acid binding;GO:0072559,cellular_component NLRP3 inflammasome complex;GO:1901612,molecular_function cardiolipin binding;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	gasdermin D [Source:HGNC Symbol%3BAcc:HGNC:25697]
ENSG00000175573	48.05	49.36	46.81	53.24	46.59	46.88	-0.0142591247054437	5.41880873772375	0.866336034571849	0.97441459136364	11:65916807-65919117:-	C11orf68	2;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding	NA	chromosome 11 open reading frame 68 [Source:HGNC Symbol%3BAcc:HGNC:28801]
ENSG00000146918	36.47	40.54	35.05	37.47	39.98	36.45	-0.0132902908906768	7.05096456647055	0.866494563016727	0.97441459136364	7:158631310-158704829:-	NCAPG2	10;GO:0000796,cellular_component condensin complex;GO:0001833,biological_process inner cell mass cell proliferation;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030261,biological_process chromosome condensation;GO:0035064,molecular_function methylated histone binding;GO:0051301,biological_process cell division	NA	non-SMC condensin II complex subunit G2 [Source:HGNC Symbol%3BAcc:HGNC:21904]
ENSG00000204305	5.79	4.95	6.51	5.49	5.78	5.86	0.0324216012289629	3.02870772675683	0.8665828414757	0.97441459136364	6:32180967-32184324:-	AGER	46;GO:0001650,cellular_component fibrillar center;GO:0001666,biological_process response to hypoxia;GO:0001914,biological_process regulation of T cell mediated cytotoxicity;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006954,biological_process inflammatory response;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0008201,molecular_function heparin binding;GO:0009611,biological_process response to wounding;GO:0010255,biological_process glucose mediated signaling pathway;GO:0014002,biological_process astrocyte development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction;GO:0031175,biological_process neuron projection development;GO:0032693,biological_process negative regulation of interleukin-10 production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0044548,molecular_function S100 protein binding;GO:0045087,biological_process innate immune response;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048167,biological_process regulation of synaptic plasticity;GO:0050727,biological_process regulation of inflammatory response;GO:0050930,biological_process induction of positive chemotaxis;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051101,biological_process regulation of DNA binding;GO:0071639,biological_process positive regulation of monocyte chemotactic protein-1 production;GO:0072657,biological_process protein localization to membrane;GO:0098794,cellular_component postsynapse;GO:1900453,biological_process negative regulation of long term synaptic depression;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1904597,biological_process negative regulation of connective tissue replacement involved in inflammatory response wound healing;GO:1904599,molecular_function advanced glycation end-product binding;GO:1904604,biological_process negative regulation of advanced glycation end-product receptor activity;GO:1904645,biological_process response to beta-amyloid;GO:2000514,biological_process regulation of CD4-positive, alpha-beta T cell activation;GO:2001200,biological_process positive regulation of dendritic cell differentiation	NA	advanced glycosylation end-product specific receptor [Source:HGNC Symbol%3BAcc:HGNC:320]
ENSG00000197102	64.86	63.74	64.61	64.49	64.21	64.85	0.00927641997672639	9.81251795653068	0.866595346112317	0.97441459136364	14:101964527-102050792:+	DYNC1H1	45;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007052,biological_process mitotic spindle organization;GO:0007062,biological_process sister chromatid cohesion;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030175,cellular_component filopodium;GO:0030286,cellular_component dynein complex;GO:0031012,cellular_component extracellular matrix;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0032388,biological_process positive regulation of intracellular transport;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0034063,biological_process stress granule assembly;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051293,biological_process establishment of spindle localization;GO:0051301,biological_process cell division;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0070062,cellular_component extracellular exosome;GO:0072382,biological_process minus-end-directed vesicle transport along microtubule;GO:0090235,biological_process regulation of metaphase plate congression;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1905832,biological_process positive regulation of spindle assembly	NA	dynein cytoplasmic 1 heavy chain 1 [Source:HGNC Symbol%3BAcc:HGNC:2961]
ENSG00000110925	8.58	8.68	7.82	7.86	9.54	8.24	-0.0221061228173285	3.79880032221867	0.866595893617844	0.97441459136364	12:51061204-51083664:-	CSRNP2	13;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019902,molecular_function phosphatase binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	cysteine and serine rich nuclear protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16006]
ENSG00000145817	55.05	60.12	57.18	55.94	62.66	56.64	-0.0145908920403014	5.48551892559335	0.86668849317961	0.97441459136364	5:144158158-144170714:-	YIPF5	17;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032580,cellular_component Golgi cisterna membrane;GO:0042175,cellular_component nuclear outer membrane-endoplasmic reticulum membrane network;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0060628,biological_process regulation of ER to Golgi vesicle-mediated transport;GO:0070971,cellular_component endoplasmic reticulum exit site	NA	Yip1 domain family member 5 [Source:HGNC Symbol%3BAcc:HGNC:24877]
ENSG00000169131	10.16	8.88	11.11	10.92	10.34	8.80	0.0236453324951887	4.32786999308397	0.866713244440986	0.97441459136364	5:178694604-178730702:-	ZNF354A	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001666,biological_process response to hypoxia;GO:0001822,biological_process kidney development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007576,biological_process nucleolar fragmentation;GO:0007605,biological_process sensory perception of sound;GO:0046872,molecular_function metal ion binding;GO:0051593,biological_process response to folic acid	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 354A [Source:HGNC Symbol%3BAcc:HGNC:11628]
ENSG00000185519	2.77	2.96	4.21	3.48	2.44	3.77	0.0517534943029536	1.54210540307837	0.867096686237841	0.974757395967245	1:16057768-16073632:-	FAM131C	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 131 member C [Source:HGNC Symbol%3BAcc:HGNC:26717]
ENSG00000070785	11.25	10.82	11.42	11.92	11.04	11.25	-0.0159874782917606	4.05418630361207	0.867238674102163	0.974763368475511	1:44850521-44986722:-	EIF2B3	19;GO:0003743,molecular_function translation initiation factor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005851,cellular_component eukaryotic translation initiation factor 2B complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0009058,biological_process biosynthetic process;GO:0009408,biological_process response to heat;GO:0009749,biological_process response to glucose;GO:0014003,biological_process oligodendrocyte development;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0021766,biological_process hippocampus development;GO:0032057,biological_process negative regulation of translational initiation in response to stress;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051716,biological_process cellular response to stimulus	EIF2B3; translation initiation factor eIF-2B subunit gamma; K03241	eukaryotic translation initiation factor 2B subunit gamma [Source:HGNC Symbol%3BAcc:HGNC:3259]
ENSG00000123810	4.56	8.63	4.75	4.95	6.12	6.24	0.0320030652701027	1.90005127737112	0.867316661130659	0.974763368475511	19:41354420-41364173:-	B9D2	17;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007062,biological_process sister chromatid cohesion;GO:0016020,cellular_component membrane;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0036038,cellular_component MKS complex;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0043015,molecular_function gamma-tubulin binding;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	B9 protein domain 2 [Source:HGNC Symbol%3BAcc:HGNC:28636]
ENSG00000156802	30.63	34.48	29.55	31.91	32.52	31.74	-0.0131172478617363	7.05427863297924	0.86733758195537	0.974763368475511	8:123319849-123416350:-	ATAD2	16;GO:0000166,molecular_function nucleotide binding;GO:0003682,molecular_function chromatin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006325,biological_process chromatin organization;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0031936,biological_process negative regulation of chromatin silencing;GO:0042393,molecular_function histone binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070062,cellular_component extracellular exosome	NA	ATPase family%2C AAA domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30123]
ENSG00000178935	3.06	3.93	3.34	3.67	2.91	4.09	-0.0508586003949199	2.34180944086103	0.867433904421035	0.9747703231227	19:57803840-57814913:-	ZNF552	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 552 [Source:HGNC Symbol%3BAcc:HGNC:26135]
ENSG00000130707	165.99	147.99	175.84	176.64	149.84	172.15	-0.0130989432421623	7.6724732342271	0.867583143383178	0.9747703231227	9:130444928-130501274:+	ASS1	22;GO:0000050,biological_process urea cycle;GO:0000052,biological_process citrulline metabolic process;GO:0000053,biological_process argininosuccinate metabolic process;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0004055,molecular_function argininosuccinate synthase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006526,biological_process arginine biosynthetic process;GO:0006531,biological_process aspartate metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0016597,molecular_function amino acid binding;GO:0016874,molecular_function ligase activity;GO:0042802,molecular_function identical protein binding;GO:0043209,cellular_component myelin sheath;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0070062,cellular_component extracellular exosome;GO:0071499,biological_process cellular response to laminar fluid shear stress;GO:1903038,biological_process negative regulation of leukocyte cell-cell adhesion	argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]; K01940	argininosuccinate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:758]
ENSG00000182768	74.37	64.50	70.03	69.04	68.65	71.43	0.0137920145272354	5.95382671421457	0.867810230073128	0.9747703231227	15:90265658-90278141:+	NGRN	7;GO:0003723,molecular_function RNA binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation	NA	neugrin%2C neurite outgrowth associated [Source:HGNC Symbol%3BAcc:HGNC:18077]
ENSG00000133731	30.60	30.74	30.80	31.01	32.14	30.59	-0.0126463021346799	5.15804645981244	0.867847286282197	0.9747703231227	8:81657960-81686693:-	IMPA1	23;GO:0000287,molecular_function magnesium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006020,biological_process inositol metabolic process;GO:0006021,biological_process inositol biosynthetic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0007165,biological_process signal transduction;GO:0008934,molecular_function inositol monophosphate 1-phosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0031403,molecular_function lithium ion binding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046872,molecular_function metal ion binding;GO:0052832,molecular_function inositol monophosphate 3-phosphatase activity;GO:0052833,molecular_function inositol monophosphate 4-phosphatase activity;GO:0052834,molecular_function inositol monophosphate phosphatase activity;GO:0070062,cellular_component extracellular exosome	E3.1.3.25, IMPA, suhB; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]; K01092	inositol monophosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:6050]
ENSG00000196470	37.91	40.20	44.60	40.19	40.87	41.49	0.013815896552443	5.26907229027966	0.867883233597848	0.9747703231227	16:48356363-48448402:-	SIAH1	33;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0008022,molecular_function protein C-terminus binding;GO:0008270,molecular_function zinc ion binding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0030163,biological_process protein catabolic process;GO:0030877,cellular_component beta-catenin destruction complex;GO:0031648,biological_process protein destabilization;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051402,biological_process neuron apoptotic process;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]; K04506	siah E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:10857]
ENSG00000176623	42.86	40.43	39.25	39.56	39.81	43.16	0.0119010542752375	5.88519909570254	0.867901475196007	0.9747703231227	8:86468256-86514357:-	RMDN1	7;GO:0000922,cellular_component spindle pole;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule	NA	regulator of microtubule dynamics 1 [Source:HGNC Symbol%3BAcc:HGNC:24285]
ENSG00000115234	96.20	88.91	91.75	93.28	91.69	92.21	0.0111727178449012	7.05387729902297	0.867997926510122	0.9747703231227	2:27370495-27377533:+	SNX17	29;GO:0003279,biological_process cardiac septum development;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006707,biological_process cholesterol catabolic process;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0030100,biological_process regulation of endocytosis;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035904,biological_process aorta development;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0050750,molecular_function low-density lipoprotein particle receptor binding;GO:0060976,biological_process coronary vasculature development;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	sorting nexin 17 [Source:HGNC Symbol%3BAcc:HGNC:14979]
ENSG00000250722	6.24	4.68	6.70	5.70	5.57	6.95	-0.023896300116277	2.81576445405639	0.868036596648653	0.9747703231227	5:42799879-42887392:-	SELENOP	15;GO:0001887,biological_process selenium compound metabolic process;GO:0002576,biological_process platelet degranulation;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006979,biological_process response to oxidative stress;GO:0007420,biological_process brain development;GO:0007626,biological_process locomotory behavior;GO:0008430,molecular_function selenium binding;GO:0009791,biological_process post-embryonic development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019953,biological_process sexual reproduction;GO:0031089,cellular_component platelet dense granule lumen;GO:0040007,biological_process growth;GO:0070062,cellular_component extracellular exosome	NA	selenoprotein P [Source:HGNC Symbol%3BAcc:HGNC:10751]
ENSG00000156504	24.74	31.38	30.78	27.78	29.10	29.49	0.0145033871229248	4.65384211339112	0.86805052378944	0.9747703231227	X:134769565-134797232:-	FAM122B	1;GO:0005581,cellular_component collagen trimer	NA	family with sequence similarity 122B [Source:HGNC Symbol%3BAcc:HGNC:30490]
ENSG00000142002	28.54	28.41	28.72	28.13	28.62	28.99	0.0106504604608458	6.4040940061848	0.86831334868998	0.974971573777272	19:4675223-4724673:-	DPP9	9;GO:0004177,molecular_function aminopeptidase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding	NA	dipeptidyl peptidase 9 [Source:HGNC Symbol%3BAcc:HGNC:18648]
ENSG00000182512	33.61	38.90	37.81	36.12	37.28	36.48	0.0125077657733133	4.82515244735089	0.8683868299107	0.974971573777272	14:95533502-95544724:+	GLRX5	16;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0009055,molecular_function electron carrier activity;GO:0009249,biological_process protein lipoylation;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0015036,molecular_function disulfide oxidoreductase activity;GO:0030097,biological_process hemopoiesis;GO:0030425,cellular_component dendrite;GO:0043025,cellular_component neuronal cell body;GO:0044281,biological_process small molecule metabolic process;GO:0045454,biological_process cell redox homeostasis;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding;GO:0055114,biological_process oxidation-reduction process	NA	glutaredoxin 5 [Source:HGNC Symbol%3BAcc:HGNC:20134]
ENSG00000150459	121.28	120.28	127.15	119.80	124.49	124.75	0.0112803126601889	6.16042541048626	0.868465951606421	0.974972221876684	13:21140513-21149084:+	SAP18	23;GO:0000118,cellular_component histone deacetylase complex;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016575,biological_process histone deacetylation;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0035145,cellular_component exon-exon junction complex;GO:0043065,biological_process positive regulation of apoptotic process;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0061574,cellular_component ASAP complex;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	SAP18; histone deacetylase complex subunit SAP18; K14324	Sin3A associated protein 18 [Source:HGNC Symbol%3BAcc:HGNC:10530]
ENSG00000136270	50.15	50.15	49.89	49.91	50.25	52.37	-0.0108882267940022	6.6302176293294	0.868679203012362	0.975060603652994	7:45100099-45112047:-	TBRG4	8;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006468,biological_process protein phosphorylation;GO:0007050,biological_process cell cycle arrest;GO:0008284,biological_process positive regulation of cell proliferation;GO:0045333,biological_process cellular respiration	NA	transforming growth factor beta regulator 4 [Source:HGNC Symbol%3BAcc:HGNC:17443]
ENSG00000157429	2.40	1.56	1.88	2.30	2.08	1.75	-0.0342391615397755	1.69051003232266	0.86870178166426	0.975060603652994	16:71464554-71565089:-	ZNF19	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 19 [Source:HGNC Symbol%3BAcc:HGNC:12981]
ENSG00000135953	5.60	5.50	4.82	4.75	5.61	5.95	-0.0282798139820939	3.05018350149865	0.868857449975848	0.975147154299295	2:102715839-102736888:-	MFSD9	5;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	major facilitator superfamily domain containing 9 [Source:HGNC Symbol%3BAcc:HGNC:28158]
ENSG00000177556	63.72	72.63	64.77	66.22	73.15	65.63	-0.022432589163624	3.94020364188449	0.868949550149374	0.975162351144035	5:151742315-151772532:-	ATOX1	18;GO:0005375,molecular_function copper ion transmembrane transporter activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006825,biological_process copper ion transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0006979,biological_process response to oxidative stress;GO:0015680,biological_process intracellular copper ion transport;GO:0016530,molecular_function metallochaperone activity;GO:0016531,molecular_function copper chaperone activity;GO:0019730,biological_process antimicrobial humoral response;GO:0030001,biological_process metal ion transport;GO:0032767,molecular_function copper-dependent protein binding;GO:0035434,biological_process copper ion transmembrane transport;GO:0046872,molecular_function metal ion binding;GO:0051117,molecular_function ATPase binding	ATOX1, ATX1, copZ, golB; copper chaperone; K07213	antioxidant 1 copper chaperone [Source:HGNC Symbol%3BAcc:HGNC:798]
ENSG00000174306	7.42	9.17	7.20	7.02	8.47	8.12	0.0149364949330945	4.65459731933238	0.869175547132125	0.975242886945233	20:41178447-41317672:-	ZHX3	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0042803,molecular_function protein homodimerization activity;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	NA	zinc fingers and homeoboxes 3 [Source:HGNC Symbol%3BAcc:HGNC:15935]
ENSG00000169598	2.79	4.15	2.11	2.73	2.59	3.44	0.0331051272970214	1.97560109217278	0.869250800872723	0.975242886945233	1:3857266-3885429:+	DFFB	21;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004536,molecular_function deoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006308,biological_process DNA catabolic process;GO:0006309,biological_process apoptotic DNA fragmentation;GO:0006915,biological_process apoptotic process;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0019904,molecular_function protein domain specific binding;GO:0030263,biological_process apoptotic chromosome condensation;GO:0042802,molecular_function identical protein binding;GO:0051260,biological_process protein homooligomerization;GO:0097718,molecular_function disordered domain specific binding	DFFB, DFF40; DNA fragmentation factor, 40 kD, beta subunit [EC:3.-.-.-]; K02311	DNA fragmentation factor subunit beta [Source:HGNC Symbol%3BAcc:HGNC:2773]
ENSG00000128652	2.56	2.29	3.80	3.52	2.05	2.88	0.0565578740985458	1.95345020938825	0.869257012902768	0.975242886945233	2:176136611-176173102:+	HOXD3	24;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007160,biological_process cell-matrix adhesion;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010628,biological_process positive regulation of gene expression;GO:0016235,cellular_component aggresome;GO:0016604,cellular_component nuclear body;GO:0021615,biological_process glossopharyngeal nerve morphogenesis;GO:0030878,biological_process thyroid gland development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0051216,biological_process cartilage development	NA	homeobox D3 [Source:HGNC Symbol%3BAcc:HGNC:5137]
ENSG00000139718	5.84	5.96	5.19	5.55	6.03	5.71	-0.0156184873159458	5.08088673580277	0.869525690701025	0.975375074781847	12:121804179-121832584:+	SETD1B	19;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation	SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]; K11422	SET domain containing 1B [Source:HGNC Symbol%3BAcc:HGNC:29187]
ENSG00000127603	21.69	23.92	20.75	21.13	24.97	21.41	-0.0132788643982597	9.31154268570187	0.869561850997777	0.975375074781847	1:39081315-39487177:+	MACF1	28;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0008017,molecular_function microtubule binding;GO:0010632,biological_process regulation of epithelial cell migration;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016887,molecular_function ATPase activity;GO:0030054,cellular_component cell junction;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0032587,cellular_component ruffle membrane;GO:0032886,biological_process regulation of microtubule-based process;GO:0042060,biological_process wound healing;GO:0042995,cellular_component cell projection;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0045296,molecular_function cadherin binding;GO:0045773,biological_process positive regulation of axon extension;GO:0046872,molecular_function metal ion binding;GO:0051015,molecular_function actin filament binding;GO:0051893,biological_process regulation of focal adhesion assembly	NA	microtubule-actin crosslinking factor 1 [Source:HGNC Symbol%3BAcc:HGNC:13664]
ENSG00000077514	15.09	15.20	12.90	14.93	12.66	15.39	0.0150548854923111	4.47668704148628	0.869728659954102	0.975375074781847	11:74493850-74669117:+	POLD3	21;GO:0000723,biological_process telomere maintenance;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006266,biological_process DNA ligation;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0019985,biological_process translesion synthesis;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043625,cellular_component delta DNA polymerase complex	POLD3; DNA polymerase delta subunit 3; K03504	DNA polymerase delta 3%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:20932]
ENSG00000150787	73.06	68.54	69.54	72.46	64.34	74.04	0.01485044767711	4.94434020292884	0.869791037116714	0.975375074781847	11:112226364-112269955:+	PTS	13;GO:0003874,molecular_function 6-pyruvoyltetrahydropterin synthase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006729,biological_process tetrahydrobiopterin biosynthetic process;GO:0007417,biological_process central nervous system development;GO:0016829,molecular_function lyase activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0050999,biological_process regulation of nitric-oxide synthase activity	queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]; K01737	6-pyruvoyltetrahydropterin synthase [Source:HGNC Symbol%3BAcc:HGNC:9689]
ENSG00000087299	12.05	10.38	13.27	11.65	12.08	12.85	-0.0154562119783899	4.33670083619788	0.869806939702949	0.975375074781847	14:50237562-50312548:-	L2HGDH	9;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0044267,biological_process cellular protein metabolic process;GO:0047545,molecular_function 2-hydroxyglutarate dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process	L2HGDH; 2-hydroxyglutarate dehydrogenase [EC:1.1.99.2]; K00109	L-2-hydroxyglutarate dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:20499]
ENSG00000153339	18.26	19.17	19.60	16.81	20.36	19.80	0.012744314218776	6.39918306802696	0.869846296450096	0.975375074781847	18:31829172-31953136:-	TRAPPC8	17;GO:0000407,cellular_component pre-autophagosomal structure;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0030242,biological_process pexophagy;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034497,biological_process protein localization to pre-autophagosomal structure;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044804,biological_process nucleophagy;GO:0061024,biological_process membrane organization;GO:1990072,cellular_component TRAPPIII protein complex	NA	trafficking protein particle complex 8 [Source:HGNC Symbol%3BAcc:HGNC:29169]
ENSG00000112249	10.29	10.00	9.82	9.83	9.82	10.46	0.0108542995851766	6.08433828593912	0.86996755410136	0.975422929189791	6:100508193-100881372:-	ASCC3	21;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0032508,biological_process DNA duplex unwinding;GO:0043140,molecular_function ATP-dependent 3'-5' DNA helicase activity;GO:0099053,cellular_component activating signal cointegrator 1 complex	NA	activating signal cointegrator 1 complex subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:18697]
ENSG00000164190	22.73	23.38	22.99	22.65	24.26	23.25	-0.0102667984574463	7.61816778805333	0.870234156919418	0.97557414760469	5:36876758-37066413:+	NIPBL	49;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0001656,biological_process metanephros development;GO:0003007,biological_process heart morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007605,biological_process sensory perception of sound;GO:0008022,molecular_function protein C-terminus binding;GO:0010468,biological_process regulation of gene expression;GO:0019827,biological_process stem cell population maintenance;GO:0031065,biological_process positive regulation of histone deacetylation;GO:0032116,cellular_component SMC loading complex;GO:0034088,biological_process maintenance of mitotic sister chromatid cohesion;GO:0034613,biological_process cellular protein localization;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035136,biological_process forelimb morphogenesis;GO:0035261,biological_process external genitalia morphogenesis;GO:0036033,molecular_function mediator complex binding;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042471,biological_process ear morphogenesis;GO:0042634,biological_process regulation of hair cycle;GO:0042826,molecular_function histone deacetylase binding;GO:0045444,biological_process fat cell differentiation;GO:0045778,biological_process positive regulation of ossification;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0045995,biological_process regulation of embryonic development;GO:0047485,molecular_function protein N-terminus binding;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048589,biological_process developmental growth;GO:0048592,biological_process eye morphogenesis;GO:0048638,biological_process regulation of developmental growth;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0050890,biological_process cognition;GO:0060325,biological_process face morphogenesis;GO:0061010,biological_process gall bladder development;GO:0061038,biological_process uterus morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0070087,molecular_function chromo shadow domain binding;GO:0071481,biological_process cellular response to X-ray	NA	NIPBL%2C cohesin loading factor [Source:HGNC Symbol%3BAcc:HGNC:28862]
ENSG00000177370	22.81	25.29	23.52	19.81	28.41	22.71	0.0229047204340508	3.80248601411157	0.870280350478492	0.97557414760469	17:997116-1003671:+	TIMM22	12;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030943,molecular_function mitochondrion targeting sequence binding;GO:0042721,cellular_component mitochondrial inner membrane protein insertion complex;GO:0045039,biological_process protein import into mitochondrial inner membrane	NA	translocase of inner mitochondrial membrane 22 [Source:HGNC Symbol%3BAcc:HGNC:17317]
ENSG00000118246	22.58	21.04	21.94	22.29	21.04	23.37	-0.01144517327165	5.55996083972791	0.870398706428847	0.97557414760469	2:206765356-206792509:+	FASTKD2	12;GO:0003723,molecular_function RNA binding;GO:0004672,molecular_function protein kinase activity;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006468,biological_process protein phosphorylation;GO:0019843,molecular_function rRNA binding;GO:0035770,cellular_component ribonucleoprotein granule;GO:0042254,biological_process ribosome biogenesis;GO:0042645,cellular_component mitochondrial nucleoid;GO:0045171,cellular_component intercellular bridge;GO:0045333,biological_process cellular respiration;GO:1902775,biological_process mitochondrial large ribosomal subunit assembly	NA	FAST kinase domains 2 [Source:HGNC Symbol%3BAcc:HGNC:29160]
ENSG00000103061	16.03	15.02	16.48	13.24	16.76	17.27	0.0220218006205268	4.02439072721125	0.8704617289283	0.97557414760469	16:68284502-68310946:-	SLC7A6OS	5;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport	NA	solute carrier family 7 member 6 opposite strand [Source:HGNC Symbol%3BAcc:HGNC:25807]
ENSG00000147174	3.75	2.31	3.09	3.00	2.96	3.53	-0.0251351299146857	2.73533450237331	0.870548199272702	0.97557414760469	X:71578410-71613583:+	GCNA	2;GO:0005634,cellular_component nucleus;GO:0080111,biological_process DNA demethylation	NA	germ cell nuclear acidic peptidase [Source:HGNC Symbol%3BAcc:HGNC:15805]
ENSG00000107672	15.03	15.03	14.73	14.21	14.58	16.87	-0.0183200968493105	4.25959350678393	0.87057398155298	0.97557414760469	10:121957087-121975217:-	NSMCE4A	11;GO:0000781,cellular_component chromosome, telomeric region;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016604,cellular_component nuclear body;GO:0030915,cellular_component Smc5-Smc6 complex;GO:2001022,biological_process positive regulation of response to DNA damage stimulus	NA	NSE4 homolog A%2C SMC5-SMC6 complex component [Source:HGNC Symbol%3BAcc:HGNC:25935]
ENSG00000198839	39.93	34.48	39.49	39.17	35.09	39.66	0.0150232039539128	5.76182511441177	0.870823013353922	0.975675058819028	7:112206587-112343096:+	ZNF277	9;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:2000772,biological_process regulation of cellular senescence	NA	zinc finger protein 277 [Source:HGNC Symbol%3BAcc:HGNC:13070]
ENSG00000047188	8.63	8.36	8.25	8.33	8.66	8.25	0.0130636555423034	5.1832258809183	0.870937761644854	0.975675058819028	5:113513682-113595285:+	YTHDC2	16;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0006396,biological_process RNA processing;GO:0008186,molecular_function RNA-dependent ATPase activity;GO:0016787,molecular_function hydrolase activity;GO:0034612,biological_process response to tumor necrosis factor;GO:0044829,biological_process positive regulation by host of viral genome replication;GO:0070063,molecular_function RNA polymerase binding;GO:0070555,biological_process response to interleukin-1;GO:1990247,molecular_function N6-methyladenosine-containing RNA binding	NA	YTH domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:24721]
ENSG00000060971	38.50	39.11	34.82	35.76	40.25	36.25	0.0123713759105196	5.6283241985447	0.870940255201871	0.975675058819028	3:38103128-38137242:-	ACAA1	23;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0003824,molecular_function catalytic activity;GO:0003988,molecular_function acetyl-CoA C-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008152,biological_process metabolic process;GO:0008206,biological_process bile acid metabolic process;GO:0008775,molecular_function acetate CoA-transferase activity;GO:0016020,cellular_component membrane;GO:0016401,molecular_function palmitoyl-CoA oxidase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0035580,cellular_component specific granule lumen;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation	ACAA1; acetyl-CoA acyltransferase 1 [EC:2.3.1.16]; K07513	acetyl-CoA acyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:82]
ENSG00000169507	1.13	0.77	1.34	1.20	0.88	1.38	-0.0634947670741224	0.772894353314864	0.870978436056847	0.975675058819028	2:164896185-164955525:-	SLC38A11	8;GO:0003333,biological_process amino acid transmembrane transport;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006865,biological_process amino acid transport;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 38 member 11 [Source:HGNC Symbol%3BAcc:HGNC:26836]
ENSG00000181029	17.91	16.94	16.83	16.06	18.02	17.21	0.0250690905757745	3.29881099731355	0.871413422566706	0.976058742515206	19:7680842-7687703:+	TRAPPC5	13;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048193,biological_process Golgi vesicle transport;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 5 [Source:HGNC Symbol%3BAcc:HGNC:23067]
ENSG00000088881	1.76	1.03	1.62	1.65	1.37	1.62	-0.0332417429680347	1.71200584069815	0.871478211817935	0.976058742515206	20:2692877-2760108:+	EBF4	11;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	early B-cell factor 4 [Source:HGNC Symbol%3BAcc:HGNC:29278]
ENSG00000113318	3.75	3.61	3.09	3.36	3.38	3.63	0.0196792592027508	3.58311473949548	0.871587490907695	0.976093064294228	5:80654647-80876460:+	MSH3	25;GO:0000166,molecular_function nucleotide binding;GO:0000403,molecular_function Y-form DNA binding;GO:0000404,molecular_function heteroduplex DNA loop binding;GO:0000406,molecular_function double-strand/single-strand DNA junction binding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0016020,cellular_component membrane;GO:0016447,biological_process somatic recombination of immunoglobulin gene segments;GO:0019899,molecular_function enzyme binding;GO:0030983,molecular_function mismatched DNA binding;GO:0032139,molecular_function dinucleotide insertion or deletion binding;GO:0032142,molecular_function single guanine insertion binding;GO:0032181,molecular_function dinucleotide repeat insertion binding;GO:0032302,cellular_component MutSbeta complex;GO:0043570,biological_process maintenance of DNA repeat elements;GO:0045910,biological_process negative regulation of DNA recombination;GO:0051096,biological_process positive regulation of helicase activity	MSH3; DNA mismatch repair protein MSH3; K08736	mutS homolog 3 [Source:HGNC Symbol%3BAcc:HGNC:7326]
ENSG00000107960	17.14	16.19	18.67	17.97	16.56	18.60	-0.0154665020786564	4.2886883198059	0.871833284350196	0.976280248862335	10:103882541-103918205:-	STN1	20;GO:0000723,biological_process telomere maintenance;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001650,cellular_component fibrillar center;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0010833,biological_process telomere maintenance via telomere lengthening;GO:0016233,biological_process telomere capping;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0042162,molecular_function telomeric DNA binding;GO:0043047,molecular_function single-stranded telomeric DNA binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0045740,biological_process positive regulation of DNA replication;GO:1990879,cellular_component CST complex	NA	STN1%2C CST complex subunit [Source:HGNC Symbol%3BAcc:HGNC:26200]
ENSG00000152795	177.07	180.74	182.08	183.85	178.41	185.67	-0.00974800577827988	7.83756928909141	0.872037240194959	0.976420554080825	4:82422563-82430408:-	HNRNPDL	14;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0019013,cellular_component viral nucleocapsid;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome	NA	heterogeneous nuclear ribonucleoprotein D like [Source:HGNC Symbol%3BAcc:HGNC:5037]
ENSG00000113621	27.04	31.34	27.62	28.53	29.99	27.15	0.0117079789767371	5.08888093245148	0.872303525268299	0.976630617764535	5:134873802-134901525:+	TXNDC15	4;GO:0005623,cellular_component cell;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045454,biological_process cell redox homeostasis	NA	thioredoxin domain containing 15 [Source:HGNC Symbol%3BAcc:HGNC:20652]
ENSG00000166333	103.97	107.28	101.98	105.68	106.89	105.33	-0.0102980256442584	7.272797555461	0.872503495806807	0.976766404531917	11:6603707-6610874:+	ILK	81;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001725,cellular_component stress fiber;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0003151,biological_process outflow tract morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0007050,biological_process cell cycle arrest;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007569,biological_process cell aging;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0010761,biological_process fibroblast migration;GO:0014044,biological_process Schwann cell development;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017124,molecular_function SH3 domain binding;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0021675,biological_process nerve development;GO:0022011,biological_process myelination in peripheral nervous system;GO:0030017,cellular_component sarcomere;GO:0030027,cellular_component lamellipodium;GO:0030030,biological_process cell projection organization;GO:0030054,cellular_component cell junction;GO:0030335,biological_process positive regulation of cell migration;GO:0030424,cellular_component axon;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0032288,biological_process myelin assembly;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034329,biological_process cell junction assembly;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042327,biological_process positive regulation of phosphorylation;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0043034,cellular_component costamere;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043195,cellular_component terminal bouton;GO:0043198,cellular_component dendritic shaft;GO:0043234,cellular_component protein complex;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043491,biological_process protein kinase B signaling;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045197,biological_process establishment or maintenance of epithelial cell apical/basal polarity;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045773,biological_process positive regulation of axon extension;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0048812,biological_process neuron projection morphogenesis;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0051291,biological_process protein heterooligomerization;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070527,biological_process platelet aggregation;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097435,biological_process fibril organization;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:2000178,biological_process negative regulation of neural precursor cell proliferation	ILK; integrin-linked kinase [EC:2.7.11.1]; K06272	integrin linked kinase [Source:HGNC Symbol%3BAcc:HGNC:6040]
ENSG00000150477	1.84	1.22	1.44	1.47	1.56	1.70	-0.0397288907191857	1.83001527716409	0.872646859436239	0.97683737876584	18:36829105-37232172:+	KIAA1328	1;GO:0005515,molecular_function protein binding	NA	KIAA1328 [Source:HGNC Symbol%3BAcc:HGNC:29248]
ENSG00000160703	10.36	10.76	10.87	10.76	11.32	9.86	0.0140218931269572	5.04371286276856	0.872729529778911	0.97683737876584	11:119166567-119184016:+	NLRX1	18;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0030054,cellular_component cell junction;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032688,biological_process negative regulation of interferon-beta production;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0039536,biological_process negative regulation of RIG-I signaling pathway;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0045824,biological_process negative regulation of innate immune response;GO:0050728,biological_process negative regulation of inflammatory response	NLRX1; NLR family member X1; K12653	NLR family member X1 [Source:HGNC Symbol%3BAcc:HGNC:29890]
ENSG00000006757	26.89	20.15	27.44	28.41	24.38	23.72	-0.0167135392298933	4.27432121890259	0.872806041676389	0.97683737876584	X:7898246-7927739:-	PNPLA4	16;GO:0003674,molecular_function molecular_function;GO:0004806,molecular_function triglyceride lipase activity;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019433,biological_process triglyceride catabolic process;GO:0042572,biological_process retinol metabolic process;GO:0050253,molecular_function retinyl-palmitate esterase activity;GO:0055088,biological_process lipid homeostasis	PNPLA4; patatin-like phospholipase domain-containing protein 4 [EC:3.1.1.-]; K11157	patatin like phospholipase domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:24887]
ENSG00000149489	3.69	2.36	3.01	2.70	3.39	3.41	-0.0352267783072377	1.78296810487219	0.873034312102073	0.97683737876584	11:62611721-62615120:+	ROM1	12;GO:0001750,cellular_component photoreceptor outer segment;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007601,biological_process visual perception;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042622,cellular_component photoreceptor outer segment membrane;GO:0060042,biological_process retina morphogenesis in camera-type eye;GO:0060219,biological_process camera-type eye photoreceptor cell differentiation;GO:0061298,biological_process retina vasculature development in camera-type eye	NA	retinal outer segment membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10254]
ENSG00000115486	22.40	24.53	23.43	22.47	23.72	24.10	0.00986466117947055	5.7559175326823	0.873044589631428	0.97683737876584	2:85544722-85561547:-	GGCX	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006464,biological_process cellular protein modification process;GO:0007596,biological_process blood coagulation;GO:0008488,molecular_function gamma-glutamyl carboxylase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0017187,biological_process peptidyl-glutamic acid carboxylation	GGCX; vitamin K-dependent gamma-carboxylase [EC:4.1.1.90]; K10106	gamma-glutamyl carboxylase [Source:HGNC Symbol%3BAcc:HGNC:4247]
ENSG00000181038	32.79	32.28	36.25	35.88	33.82	33.70	-0.0142185902871397	4.37071483501088	0.873086507468542	0.97683737876584	17:76726829-76733936:+	METTL23	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008134,molecular_function transcription factor binding;GO:0008168,molecular_function methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0031072,molecular_function heat shock protein binding;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050890,biological_process cognition	NA	methyltransferase like 23 [Source:HGNC Symbol%3BAcc:HGNC:26988]
ENSG00000149573	9.96	10.08	9.81	10.80	10.58	9.27	-0.0249713683622288	2.73388757163037	0.873117756981148	0.97683737876584	11:118253402-118264536:-	MPZL2	8;GO:0005515,molecular_function protein binding;GO:0005856,cellular_component cytoskeleton;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion	NA	myelin protein zero like 2 [Source:HGNC Symbol%3BAcc:HGNC:3496]
ENSG00000167676	0.81	1.00	1.34	1.14	0.81	1.11	0.047071343066806	2.14419832201428	0.873571115980053	0.977156861685189	19:4502179-4518465:-	PLIN4	6;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	perilipin 4 [Source:HGNC Symbol%3BAcc:HGNC:29393]
ENSG00000105085	0.85	0.74	0.63	0.83	0.62	0.69	0.0607690913337771	0.887007556457036	0.873611149718475	0.977156861685189	19:16574906-16629062:-	MED26	10;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016592,cellular_component mediator complex	NA	mediator complex subunit 26 [Source:HGNC Symbol%3BAcc:HGNC:2376]
ENSG00000154027	64.22	65.13	68.06	71.01	59.29	70.44	-0.012549488897669	6.80892011233286	0.873639478851384	0.977156861685189	1:77282050-77559969:+	AK5	20;GO:0000166,molecular_function nucleotide binding;GO:0004017,molecular_function adenylate kinase activity;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006172,biological_process ADP biosynthetic process;GO:0006173,biological_process dADP biosynthetic process;GO:0009142,biological_process nucleoside triphosphate biosynthetic process;GO:0009220,biological_process pyrimidine ribonucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0019206,molecular_function nucleoside kinase activity;GO:0046034,biological_process ATP metabolic process	adk, AK; adenylate kinase [EC:2.7.4.3]; K00939	adenylate kinase 5 [Source:HGNC Symbol%3BAcc:HGNC:365]
ENSG00000130413	3.94	3.90	3.01	3.64	3.39	4.15	-0.0404286632867822	2.53958420599538	0.87386276353672	0.977230447386395	11:8391867-8594289:-	STK33	15;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046777,biological_process protein autophosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	serine/threonine kinase 33 [Source:HGNC Symbol%3BAcc:HGNC:14568]
ENSG00000116906	42.41	47.08	43.37	45.88	43.54	45.47	-0.0124351495088546	6.51074191474258	0.873919458837342	0.977230447386395	1:231241206-231277973:+	GNPAT	26;GO:0003824,molecular_function catalytic activity;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0007416,biological_process synapse assembly;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0008611,biological_process ether lipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016287,molecular_function glycerone-phosphate O-acyltransferase activity;GO:0016290,molecular_function palmitoyl-CoA hydrolase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0021587,biological_process cerebellum morphogenesis;GO:0030913,biological_process paranodal junction assembly;GO:0042493,biological_process response to drug;GO:0042552,biological_process myelination;GO:0042594,biological_process response to starvation;GO:0044255,biological_process cellular lipid metabolic process;GO:0061024,biological_process membrane organization;GO:0070542,biological_process response to fatty acid	GNPAT; glyceronephosphate O-acyltransferase [EC:2.3.1.42]; K00649	glyceronephosphate O-acyltransferase [Source:HGNC Symbol%3BAcc:HGNC:4416]
ENSG00000118369	4.14	3.85	3.61	3.97	4.12	3.43	0.0249257697695229	3.5758359496111	0.873959916316299	0.977230447386395	11:78188811-78214711:+	USP35	8;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 35 [Source:HGNC Symbol%3BAcc:HGNC:20061]
ENSG00000111731	12.88	12.90	12.95	11.26	14.35	13.06	0.0142677327341841	5.45081431127056	0.874105157754605	0.977230447386395	12:22448582-22544546:-	C2CD5	25;GO:0001726,cellular_component ruffle;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0006906,biological_process vesicle fusion;GO:0008289,molecular_function lipid binding;GO:0010828,biological_process positive regulation of glucose transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031340,biological_process positive regulation of vesicle fusion;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032587,cellular_component ruffle membrane;GO:0032869,biological_process cellular response to insulin stimulus;GO:0038028,biological_process insulin receptor signaling pathway via phosphatidylinositol 3-kinase;GO:0042995,cellular_component cell projection;GO:0065002,biological_process intracellular protein transmembrane transport;GO:0072659,biological_process protein localization to plasma membrane;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	NA	C2 calcium dependent domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:29062]
ENSG00000121964	9.52	9.84	9.52	9.69	9.25	9.81	0.0154203799715507	3.84106480686522	0.874162172204854	0.977230447386395	2:143938067-144332568:-	GTDC1	2;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups	NA	glycosyltransferase like domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20887]
ENSG00000196498	26.59	25.79	27.30	26.87	25.99	26.96	0.0098684193194496	7.67887561195449	0.874243923561626	0.977230447386395	12:124324414-124567589:-	NCOR2	33;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0001012,molecular_function RNA polymerase II regulatory region DNA binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005112,molecular_function Notch binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007595,biological_process lactation;GO:0008134,molecular_function transcription factor binding;GO:0010243,biological_process response to organonitrogen compound;GO:0016020,cellular_component membrane;GO:0016363,cellular_component nuclear matrix;GO:0016604,cellular_component nuclear body;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0017053,cellular_component transcriptional repressor complex;GO:0019216,biological_process regulation of lipid metabolic process;GO:0032355,biological_process response to estradiol;GO:0032403,molecular_function protein complex binding;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0042826,molecular_function histone deacetylase binding;GO:0042974,molecular_function retinoic acid receptor binding;GO:0044849,biological_process estrous cycle;GO:0046965,molecular_function retinoid X receptor binding;GO:0047485,molecular_function protein N-terminus binding;GO:0072365,biological_process regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter;GO:1903799,biological_process negative regulation of production of miRNAs involved in gene silencing by miRNA	NCOR2, SMRT; nuclear receptor co-repressor 2; K06065	nuclear receptor corepressor 2 [Source:HGNC Symbol%3BAcc:HGNC:7673]
ENSG00000197372	4.03	5.63	4.37	4.66	5.16	4.51	-0.0338878247738997	3.3156332933015	0.874256353679684	0.977230447386395	19:23525630-23687220:-	ZNF675	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0008270,molecular_function zinc ion binding;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0043508,biological_process negative regulation of JUN kinase activity;GO:0045453,biological_process bone resorption;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:2000660,biological_process negative regulation of interleukin-1-mediated signaling pathway;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 675 [Source:HGNC Symbol%3BAcc:HGNC:30768]
ENSG00000160218	8.58	9.06	9.61	8.55	9.43	9.24	0.0129147016214808	5.1228804748287	0.874433413408312	0.977264583469495	21:44012318-44106552:+	TRAPPC10	19;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006814,biological_process sodium ion transport;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015081,molecular_function sodium ion transmembrane transporter activity;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0034498,biological_process early endosome to Golgi transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048208,biological_process COPII vesicle coating;GO:0051259,biological_process protein oligomerization;GO:0061024,biological_process membrane organization;GO:1990071,cellular_component TRAPPII protein complex	NA	trafficking protein particle complex 10 [Source:HGNC Symbol%3BAcc:HGNC:11868]
ENSG00000127483	131.16	135.35	127.38	124.28	136.45	133.56	0.00989825453909506	7.81141441258778	0.874461802736035	0.977264583469495	1:20742660-20787323:-	HP1BP3	14;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0006334,biological_process nucleosome assembly;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016607,cellular_component nuclear speck;GO:0031491,molecular_function nucleosome binding;GO:0042127,biological_process regulation of cell proliferation;GO:0070828,biological_process heterochromatin organization;GO:0071456,biological_process cellular response to hypoxia;GO:0097298,biological_process regulation of nucleus size	NA	heterochromatin protein 1 binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:24973]
ENSG00000073464	1.33	1.22	1.45	0.85	1.56	1.48	0.0543357250196486	1.66242180927413	0.874540592715549	0.977264583469495	X:10156944-10237660:+	CLCN4	22;GO:0000166,molecular_function nucleotide binding;GO:0005216,molecular_function ion channel activity;GO:0005247,molecular_function voltage-gated chloride channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005524,molecular_function ATP binding;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0010008,cellular_component endosome membrane;GO:0015297,molecular_function antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0034220,biological_process ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:1902476,biological_process chloride transmembrane transport;GO:1903959,biological_process regulation of anion transmembrane transport	NA	chloride voltage-gated channel 4 [Source:HGNC Symbol%3BAcc:HGNC:2022]
ENSG00000043143	10.76	11.63	11.21	11.14	12.34	10.01	0.0152180200806988	4.81568295839638	0.874601809213133	0.977264583469495	5:134524311-134583230:+	JADE2	18;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000209,biological_process protein polyubiquitination;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0043966,biological_process histone H3 acetylation;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043983,biological_process histone H4-K12 acetylation;GO:0046872,molecular_function metal ion binding;GO:0050767,biological_process regulation of neurogenesis;GO:0050769,biological_process positive regulation of neurogenesis;GO:0051865,biological_process protein autoubiquitination;GO:0060395,biological_process SMAD protein signal transduction;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070062,cellular_component extracellular exosome;GO:1990138,biological_process neuron projection extension	NA	jade family PHD finger 2 [Source:HGNC Symbol%3BAcc:HGNC:22984]
ENSG00000121797	2.84	2.86	3.38	3.51	3.27	2.17	0.0433070852312713	1.74757199978776	0.874921027051669	0.977351543921012	3:46407162-46412997:+	CCRL2	14;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0004950,molecular_function chemokine receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042379,molecular_function chemokine receptor binding;GO:0048020,molecular_function CCR chemokine receptor binding;GO:0070098,biological_process chemokine-mediated signaling pathway	NA	C-C motif chemokine receptor like 2 [Source:HGNC Symbol%3BAcc:HGNC:1612]
ENSG00000196505	9.91	6.11	8.45	8.79	7.37	8.16	0.0328779418117083	3.66949896693497	0.875032825109363	0.977351543921012	1:117863484-117929630:-	GDAP2	3;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0032526,biological_process response to retinoic acid	NA	ganglioside induced differentiation associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:18010]
ENSG00000055070	95.73	101.90	101.64	98.33	109.54	96.26	-0.0120832167147658	6.06481037427563	0.875040683871863	0.977351543921012	1:16352574-16398145:+	SZRD1	NA	NA	SUZ RNA binding domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:30232]
ENSG00000140006	14.48	13.42	13.06	13.99	12.67	15.20	-0.0200637811453831	4.01886988772955	0.875051518835536	0.977351543921012	14:63597038-63641861:-	WDR89	NA	NA	WD repeat domain 89 [Source:HGNC Symbol%3BAcc:HGNC:20489]
ENSG00000134262	13.25	12.24	13.61	13.34	12.04	13.70	0.0157262347899803	4.86307934765399	0.875073315003475	0.977351543921012	1:113894747-113905201:-	AP4B1	15;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030131,cellular_component clathrin adaptor complex;GO:0031904,cellular_component endosome lumen;GO:0032588,cellular_component trans-Golgi network membrane	AP4B1; AP-4 complex subunit beta-1; K12401	adaptor related protein complex 4 beta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:572]
ENSG00000280071	7.00	7.63	9.45	9.00	6.68	9.10	-0.0293260214457332	3.17807372676215	0.875171799548156	0.977373598541724	21:5079293-5128425:-	FP565260.6	1;GO:0005739,cellular_component mitochondrion	NA	NA
ENSG00000141854	3.45	2.41	2.12	3.07	2.58	2.21	0.0487224155228829	1.67403000104619	0.875317613704067	0.977430180795225	19:14072535-14075062:+	MISP3	NA	NA	MISP family member 3 [Source:HGNC Symbol%3BAcc:HGNC:26963]
ENSG00000105655	2.44	2.03	3.04	3.01	1.86	2.55	0.0398351932779829	2.21539950321198	0.875471287616986	0.977430180795225	19:18434387-18438301:-	ISYNA1	9;GO:0004512,molecular_function inositol-3-phosphate synthase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006021,biological_process inositol biosynthetic process;GO:0006629,biological_process lipid metabolic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016853,molecular_function isomerase activity;GO:0043647,biological_process inositol phosphate metabolic process	INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]; K01858	inositol-3-phosphate synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:29821]
ENSG00000188878	2.79	2.78	2.79	2.69	3.00	2.86	-0.0197903296691485	3.3819477474695	0.875534036061672	0.977430180795225	17:75909573-75941140:-	FBF1	15;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0030030,biological_process cell projection organization;GO:0030054,cellular_component cell junction;GO:0043296,cellular_component apical junction complex;GO:0043297,biological_process apical junction assembly;GO:0045095,cellular_component keratin filament;GO:0060271,biological_process cilium morphogenesis;GO:0090162,biological_process establishment of epithelial cell polarity;GO:0097539,cellular_component ciliary transition fiber;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	Fas binding factor 1 [Source:HGNC Symbol%3BAcc:HGNC:24674]
ENSG00000117697	28.90	27.69	27.59	29.47	28.27	27.97	-0.0126402134415258	4.77838043333088	0.875574912072935	0.977430180795225	1:212726152-212791782:-	NSL1	15;GO:0000070,biological_process mitotic sister chromatid segregation;GO:0000444,cellular_component MIS12/MIND type complex;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0016607,cellular_component nuclear speck;GO:0051301,biological_process cell division	NA	NSL1%2C MIS12 kinetochore complex component [Source:HGNC Symbol%3BAcc:HGNC:24548]
ENSG00000173264	15.31	15.90	15.10	17.64	14.78	13.70	0.0171167811677544	4.58112563779942	0.875767064900137	0.977430180795225	11:64270061-64289500:+	GPR137	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	G protein-coupled receptor 137 [Source:HGNC Symbol%3BAcc:HGNC:24300]
ENSG00000111676	42.77	37.93	43.91	39.81	41.55	43.37	0.0120069644458686	7.21620057300624	0.875804435270267	0.977430180795225	12:6924462-6942321:+	ATN1	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007417,biological_process central nervous system development;GO:0016363,cellular_component nuclear matrix;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051402,biological_process neuron apoptotic process	NA	atrophin 1 [Source:HGNC Symbol%3BAcc:HGNC:3033]
ENSG00000134986	101.00	115.75	111.24	104.97	118.88	109.50	-0.0148975697444599	5.44115776137552	0.875856432387441	0.977430180795225	5:111662620-111997464:-	NREP	2;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm	NA	neuronal regeneration related protein [Source:HGNC Symbol%3BAcc:HGNC:16834]
ENSG00000136206	2.17	1.42	1.10	1.78	1.66	1.53	-0.0564272843488062	0.83627120810667	0.876053335778959	0.977430180795225	7:44000888-44010122:+	SPDYE1	2;GO:0019901,molecular_function protein kinase binding;GO:0045859,biological_process regulation of protein kinase activity	NA	speedy/RINGO cell cycle regulator family member E1 [Source:HGNC Symbol%3BAcc:HGNC:16408]
ENSG00000162928	22.17	17.34	20.01	20.87	18.82	21.16	-0.0128096232874904	4.72538716517175	0.876063727203188	0.977430180795225	2:61017224-61051990:+	PEX13	16;GO:0001561,biological_process fatty acid alpha-oxidation;GO:0001764,biological_process neuron migration;GO:0001967,biological_process suckling behavior;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0006810,biological_process transport;GO:0007626,biological_process locomotory behavior;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016560,biological_process protein import into peroxisome matrix, docking;GO:0021795,biological_process cerebral cortex cell migration;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0060152,biological_process microtubule-based peroxisome localization	PEX13; peroxin-13; K13344	peroxisomal biogenesis factor 13 [Source:HGNC Symbol%3BAcc:HGNC:8855]
ENSG00000198586	19.75	21.17	22.80	21.93	19.96	22.92	-0.0134585049954551	5.70381246898787	0.876064082849026	0.977430180795225	2:170990822-171231314:-	TLK1	16;GO:0000166,molecular_function nucleotide binding;GO:0001672,biological_process regulation of chromatin assembly or disassembly;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006468,biological_process protein phosphorylation;GO:0006886,biological_process intracellular protein transport;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0035556,biological_process intracellular signal transduction	NA	tousled like kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:11841]
ENSG00000120370	9.42	10.53	9.87	9.88	9.79	9.92	0.0159521766477397	3.83187068259025	0.876202180316599	0.977430180795225	1:170532128-170553446:+	GORAB	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0031069,biological_process hair follicle morphogenesis;GO:1901622,biological_process positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:1905515,biological_process non-motile cilium assembly	NA	golgin%2C RAB6 interacting [Source:HGNC Symbol%3BAcc:HGNC:25676]
ENSG00000140153	13.75	15.21	11.89	14.14	12.77	13.72	0.0128563608612601	4.80772966090662	0.876348658133376	0.977430180795225	14:102139502-102224847:+	WDR20	4;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0016579,biological_process protein deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	WD repeat domain 20 [Source:HGNC Symbol%3BAcc:HGNC:19667]
ENSG00000063587	3.90	5.20	4.35	4.83	4.01	4.92	-0.0390789817014669	2.57516221448963	0.876449915172137	0.977430180795225	X:153334154-153360110:+	ZNF275	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 275 [Source:HGNC Symbol%3BAcc:HGNC:13069]
ENSG00000100316	1454.83	1408.19	1496.31	1533.30	1396.49	1494.30	-0.00948267527639605	11.1618937286174	0.876483346823744	0.977430180795225	22:39312881-39320389:-	RPL3	23;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0008097,molecular_function 5S rRNA binding;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043234,cellular_component protein complex;GO:0070062,cellular_component extracellular exosome;GO:0071353,biological_process cellular response to interleukin-4	RP-L3e, RPL3; large subunit ribosomal protein L3e; K02925	ribosomal protein L3 [Source:HGNC Symbol%3BAcc:HGNC:10332]
ENSG00000177613	14.03	12.00	14.38	13.94	12.68	13.77	0.0189463034033928	4.6504606003951	0.876489799446004	0.977430180795225	10:51695486-51699591:-	CSTF2T	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0031124,biological_process mRNA 3'-end processing;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation	CSTF2, RNA15; cleavage stimulation factor subunit 2; K14407	cleavage stimulation factor subunit 2 tau variant [Source:HGNC Symbol%3BAcc:HGNC:17086]
ENSG00000183020	38.67	39.67	37.73	38.82	41.11	37.91	-0.0105777750590855	6.91403701910551	0.87650582574084	0.977430180795225	11:924893-1012245:+	AP2A2	36;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007018,biological_process microtubule-based movement;GO:0008289,molecular_function lipid binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030117,cellular_component membrane coat;GO:0030122,cellular_component AP-2 adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0030669,cellular_component clathrin-coated endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032802,biological_process low-density lipoprotein particle receptor catabolic process;GO:0034383,biological_process low-density lipoprotein particle clearance;GO:0035615,molecular_function clathrin adaptor activity;GO:0036020,cellular_component endolysosome membrane;GO:0043312,biological_process neutrophil degranulation;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050690,biological_process regulation of defense response to virus by virus;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0097718,molecular_function disordered domain specific binding;GO:0101003,cellular_component ficolin-1-rich granule membrane	AP2A; AP-2 complex subunit alpha; K11824	adaptor related protein complex 2 alpha 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:562]
ENSG00000088832	216.62	231.38	216.55	222.51	225.28	217.32	0.00946064029562374	7.15228280320967	0.876561086974337	0.977430180795225	20:1368977-1393172:-	FKBP1A	60;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003007,biological_process heart morphogenesis;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0004871,molecular_function signal transducer activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005527,molecular_function macrolide binding;GO:0005528,molecular_function FK506 binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006458,biological_process 'de novo' protein folding;GO:0006936,biological_process muscle contraction;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007183,biological_process SMAD protein complex assembly;GO:0008144,molecular_function drug binding;GO:0010039,biological_process response to iron ion;GO:0014802,cellular_component terminal cisterna;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016853,molecular_function isomerase activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019899,molecular_function enzyme binding;GO:0022417,biological_process protein maturation by protein folding;GO:0030018,cellular_component Z disc;GO:0030544,molecular_function Hsp70 protein binding;GO:0031000,biological_process response to caffeine;GO:0031312,cellular_component extrinsic component of organelle membrane;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032092,biological_process positive regulation of protein binding;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity;GO:0032880,biological_process regulation of protein localization;GO:0032925,biological_process regulation of activin receptor signaling pathway;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0042026,biological_process protein refolding;GO:0042098,biological_process T cell proliferation;GO:0042110,biological_process T cell activation;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043679,cellular_component axon terminus;GO:0044325,molecular_function ion channel binding;GO:0046332,molecular_function SMAD binding;GO:0048185,molecular_function activin binding;GO:0050776,biological_process regulation of immune response;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0055010,biological_process ventricular cardiac muscle tissue morphogenesis;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0060347,biological_process heart trabecula formation;GO:0061077,biological_process chaperone-mediated protein folding;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport;GO:0097435,biological_process fibril organization;GO:0098562,cellular_component cytoplasmic side of membrane;GO:1902991,biological_process regulation of amyloid precursor protein catabolic process;GO:1990000,biological_process amyloid fibril formation;GO:1990425,cellular_component ryanodine receptor complex	NA	FK506 binding protein 1A [Source:HGNC Symbol%3BAcc:HGNC:3711]
ENSG00000119414	48.34	49.44	49.34	48.16	47.36	51.63	0.0102054003300076	5.71195140055064	0.876817784184979	0.977539578886828	9:125146572-125189939:-	PPP6C	12;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000139,cellular_component Golgi membrane;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0048208,biological_process COPII vesicle coating	NA	protein phosphatase 6 catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9323]
ENSG00000144134	13.89	14.13	15.30	14.83	14.17	14.02	0.0229728091141768	3.38907625749041	0.87682836828728	0.977539578886828	2:113627228-113643396:+	RABL2A	5;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction	NA	RAB%2C member of RAS oncogene family like 2A [Source:HGNC Symbol%3BAcc:HGNC:9799]
ENSG00000241837	26.99	24.84	23.94	24.25	26.07	25.27	0.0174374216173924	4.16436953933615	0.87689544919881	0.977539578886828	21:33903452-33915980:-	ATP5O	22;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0005886,cellular_component plasma membrane;GO:0006754,biological_process ATP biosynthetic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008144,molecular_function drug binding;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0022857,molecular_function transmembrane transporter activity;GO:0031012,cellular_component extracellular matrix;GO:0042407,biological_process cristae formation;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0046933,molecular_function proton-transporting ATP synthase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport	ATPeF0O, ATP5O, ATP5; F-type H+-transporting ATPase subunit O; K02137	ATP synthase%2C H+ transporting%2C mitochondrial F1 complex%2C O subunit [Source:HGNC Symbol%3BAcc:HGNC:850]
ENSG00000136273	18.91	18.91	19.39	17.55	20.22	19.28	0.0160200494308197	4.15976801678706	0.87704700775767	0.977620735209766	7:47695729-47979581:-	HUS1	25;GO:0000077,biological_process DNA damage checkpoint;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0001932,biological_process regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0008156,biological_process negative regulation of DNA replication;GO:0009411,biological_process response to UV;GO:0009790,biological_process embryo development;GO:0030896,cellular_component checkpoint clamp complex;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0033314,biological_process mitotic DNA replication checkpoint;GO:0035861,cellular_component site of double-strand break;GO:0044778,biological_process meiotic DNA integrity checkpoint;GO:0071479,biological_process cellular response to ionizing radiation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	HUS1; HUS1 checkpoint protein; K10903	HUS1 checkpoint clamp component [Source:HGNC Symbol%3BAcc:HGNC:5309]
ENSG00000169087	4.53	3.79	4.63	4.55	3.78	4.51	0.0325516019621494	2.69572580082786	0.877234926433884	0.977681183080421	3:122740002-122793824:-	HSPBAP1	2;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm	NA	HSPB1 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16389]
ENSG00000213551	52.06	46.80	47.46	53.56	43.85	51.66	-0.0133572847118983	5.27131231822279	0.87725876235799	0.977681183080421	10:73183361-73248862:-	DNAJC9	10;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0031072,molecular_function heat shock protein binding;GO:0032781,biological_process positive regulation of ATPase activity;GO:0035176,biological_process social behavior	NA	DnaJ heat shock protein family (Hsp40) member C9 [Source:HGNC Symbol%3BAcc:HGNC:19123]
ENSG00000176444	37.03	37.15	41.00	38.91	35.82	40.49	0.011996879652912	5.85061015823462	0.87743830521203	0.977793489774389	1:155262867-155278491:-	CLK2	23;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006468,biological_process protein phosphorylation;GO:0010033,biological_process response to organic substance;GO:0010212,biological_process response to ionizing radiation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016604,cellular_component nuclear body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0032526,biological_process response to retinoic acid;GO:0042802,molecular_function identical protein binding;GO:0043484,biological_process regulation of RNA splicing;GO:0045721,biological_process negative regulation of gluconeogenesis;GO:0046777,biological_process protein autophosphorylation	NA	CDC like kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:2069]
ENSG00000148341	44.42	40.34	43.22	45.21	41.02	43.95	-0.00998761351659155	5.7804808747746	0.877727192556017	0.977960375749229	9:129007035-129028303:-	SH3GLB2	6;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0042802,molecular_function identical protein binding;GO:0045296,molecular_function cadherin binding	SH3GLB1; endophilin-B1; K11248	SH3 domain containing GRB2 like%2C endophilin B2 [Source:HGNC Symbol%3BAcc:HGNC:10834]
ENSG00000197646	1.72	2.33	2.43	2.19	2.41	2.23	-0.0747184979185449	0.973754679039881	0.87774563330558	0.977960375749229	9:5510569-5571254:+	PDCD1LG2	14;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031295,biological_process T cell costimulation;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032693,biological_process negative regulation of interleukin-10 production;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0046007,biological_process negative regulation of activated T cell proliferation;GO:0070062,cellular_component extracellular exosome	PDCD1LG2, CD273; programmed cell death 1 ligand 2; K06708	programmed cell death 1 ligand 2 [Source:HGNC Symbol%3BAcc:HGNC:18731]
ENSG00000101199	49.47	51.27	52.50	51.15	50.72	51.53	0.00991898388696583	6.52106970670887	0.877886474788231	0.978029510998592	20:63272784-63289793:+	ARFGAP1	16;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0030100,biological_process regulation of endocytosis;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding	ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1; K12492	ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15852]
ENSG00000143374	15.18	16.28	14.18	13.94	16.55	15.02	0.012562316135924	5.03752732745695	0.877979942880789	0.978045861166583	1:150487363-150507609:+	TARS2	18;GO:0000166,molecular_function nucleotide binding;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004829,molecular_function threonine-tRNA ligase activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006435,biological_process threonyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0016874,molecular_function ligase activity;GO:0016876,molecular_function ligase activity, forming aminoacyl-tRNA and related compounds;GO:0042803,molecular_function protein homodimerization activity;GO:0043039,biological_process tRNA aminoacylation;GO:0070159,biological_process mitochondrial threonyl-tRNA aminoacylation	TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]; K01868	threonyl-tRNA synthetase 2%2C mitochondrial (putative) [Source:HGNC Symbol%3BAcc:HGNC:30740]
ENSG00000164576	18.14	17.06	17.96	16.37	19.75	16.65	0.0274943581496562	3.30079949696406	0.878280356917107	0.978292719886221	5:154445956-154461054:+	SAP30L	18;GO:0000118,cellular_component histone deacetylase complex;GO:0003677,molecular_function DNA binding;GO:0003712,molecular_function transcription cofactor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0008289,molecular_function lipid binding;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0016575,biological_process histone deacetylation;GO:0031491,molecular_function nucleosome binding;GO:0042393,molecular_function histone binding;GO:0044378,molecular_function non-sequence-specific DNA binding, bending;GO:0046872,molecular_function metal ion binding	NA	SAP30 like [Source:HGNC Symbol%3BAcc:HGNC:25663]
ENSG00000117000	8.34	9.45	8.45	8.14	9.47	9.05	-0.0148236716614556	5.66513963654595	0.878559379229637	0.978515708782188	1:40161372-40240921:+	RLF	14;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0015074,biological_process DNA integration;GO:0044030,biological_process regulation of DNA methylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051276,biological_process chromosome organization;GO:0097692,biological_process histone H3-K4 monomethylation	NA	rearranged L-myc fusion [Source:HGNC Symbol%3BAcc:HGNC:10025]
ENSG00000244165	2.01	1.11	0.98	1.53	1.22	1.63	-0.0610544461521367	0.815069153266853	0.879001060624812	0.978820447958221	19:10111537-10115372:+	P2RY11	21;GO:0001973,biological_process adenosine receptor signaling pathway;GO:0004871,molecular_function signal transducer activity;GO:0004872,molecular_function receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006952,biological_process defense response;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007200,biological_process phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019722,biological_process calcium-mediated signaling;GO:0023041,biological_process neuronal signal transduction;GO:0030594,molecular_function neurotransmitter receptor activity;GO:0035589,biological_process G-protein coupled purinergic nucleotide receptor signaling pathway;GO:0045028,molecular_function G-protein coupled purinergic nucleotide receptor activity;GO:0045031,molecular_function ATP-activated adenosine receptor activity;GO:0071318,biological_process cellular response to ATP	NA	purinergic receptor P2Y11 [Source:HGNC Symbol%3BAcc:HGNC:8540]
ENSG00000012048	8.44	8.93	7.12	7.64	8.29	8.49	0.0117971034648973	5.57475933864491	0.879109227421913	0.978820447958221	17:43044294-43170245:-	BRCA1	95;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000729,biological_process DNA double-strand break processing;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000793,cellular_component condensed chromosome;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000800,cellular_component lateral element;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006301,biological_process postreplication repair;GO:0006302,biological_process double-strand break repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006349,biological_process regulation of gene expression by genetic imprinting;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007098,biological_process centrosome cycle;GO:0008270,molecular_function zinc ion binding;GO:0008274,cellular_component gamma-tubulin ring complex;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009048,biological_process dosage compensation by inactivation of X chromosome;GO:0010212,biological_process response to ionizing radiation;GO:0010575,biological_process positive regulation of vascular endothelial growth factor production;GO:0010628,biological_process positive regulation of gene expression;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0030521,biological_process androgen receptor signaling pathway;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031436,cellular_component BRCA1-BARD1 complex;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035067,biological_process negative regulation of histone acetylation;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0043009,biological_process chordate embryonic development;GO:0043234,cellular_component protein complex;GO:0043627,biological_process response to estrogen;GO:0044030,biological_process regulation of DNA methylation;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044818,biological_process mitotic G2/M transition checkpoint;GO:0045717,biological_process negative regulation of fatty acid biosynthetic process;GO:0045739,biological_process positive regulation of DNA repair;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046600,biological_process negative regulation of centriole replication;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0051572,biological_process negative regulation of histone H3-K4 methylation;GO:0051573,biological_process negative regulation of histone H3-K9 methylation;GO:0051574,biological_process positive regulation of histone H3-K9 methylation;GO:0051865,biological_process protein autoubiquitination;GO:0070512,biological_process positive regulation of histone H4-K20 methylation;GO:0070531,cellular_component BRCA1-A complex;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071681,biological_process cellular response to indole-3-methanol;GO:0085020,biological_process protein K6-linked ubiquitination;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2000617,biological_process positive regulation of histone H3-K9 acetylation;GO:2000620,biological_process positive regulation of histone H4-K16 acetylation	BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]; K10605	BRCA1%2C DNA repair associated [Source:HGNC Symbol%3BAcc:HGNC:1100]
ENSG00000132561	28.22	30.74	26.81	28.64	31.03	27.44	-0.0126449902570764	6.43879509994994	0.87921441907183	0.978820447958221	8:97868839-98036716:+	MATN2	15;GO:0001764,biological_process neuron migration;GO:0003674,molecular_function molecular_function;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0007411,biological_process axon guidance;GO:0008150,biological_process biological_process;GO:0008347,biological_process glial cell migration;GO:0031012,cellular_component extracellular matrix;GO:0031104,biological_process dendrite regeneration;GO:0031175,biological_process neuron projection development;GO:0048678,biological_process response to axon injury	NA	matrilin 2 [Source:HGNC Symbol%3BAcc:HGNC:6908]
ENSG00000187231	8.70	7.30	8.11	7.98	9.03	7.07	0.022763112125993	4.1318413363824	0.879276307255	0.978820447958221	2:179101691-179264790:-	SESTD1	10;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0010314,molecular_function phosphatidylinositol-5-phosphate binding;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0034704,cellular_component calcium channel complex;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0070300,molecular_function phosphatidic acid binding;GO:0080025,molecular_function phosphatidylinositol-3,5-bisphosphate binding;GO:1904878,biological_process negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	NA	SEC14 and spectrin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18379]
ENSG00000142634	52.80	54.33	50.42	53.09	50.87	53.50	0.00999119068447709	5.45411247076209	0.879332427912099	0.978820447958221	1:15409894-15430343:+	EFHD2	5;GO:0005509,molecular_function calcium ion binding;GO:0016020,cellular_component membrane;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0046872,molecular_function metal ion binding	NA	EF-hand domain family member D2 [Source:HGNC Symbol%3BAcc:HGNC:28670]
ENSG00000156973	46.93	44.60	43.34	47.59	46.85	40.16	0.0173233605865543	4.3481270493227	0.87938754564764	0.978820447958221	2:231732424-231786272:-	PDE6D	15;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0005095,molecular_function GTPase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0007601,biological_process visual perception;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034260,biological_process negative regulation of GTPase activity;GO:0042995,cellular_component cell projection;GO:0050896,biological_process response to stimulus	PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; K13758	phosphodiesterase 6D [Source:HGNC Symbol%3BAcc:HGNC:8788]
ENSG00000119402	33.19	35.01	33.83	33.92	35.86	33.82	-0.0120138832436964	5.54939807116676	0.879437606973353	0.978820447958221	9:120751977-120793412:-	FBXW2	7;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0043687,biological_process post-translational protein modification	NA	F-box and WD repeat domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:13608]
ENSG00000163877	14.17	13.75	11.65	13.65	13.10	12.65	0.0165261804024172	4.05358364961809	0.879542786314546	0.978820447958221	1:37534448-37554344:-	SNIP1	11;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0031047,biological_process gene silencing by RNA;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	Smad nuclear interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30587]
ENSG00000135148	17.04	13.13	14.47	15.34	14.91	15.35	-0.011899734451022	4.76451159216858	0.879605256956317	0.978820447958221	12:112125500-112153609:+	TRAFD1	4;GO:0005515,molecular_function protein binding;GO:0034097,biological_process response to cytokine;GO:0045824,biological_process negative regulation of innate immune response;GO:0046872,molecular_function metal ion binding	NA	TRAF-type zinc finger domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:24808]
ENSG00000124216	13.64	13.39	13.66	12.57	13.60	14.29	0.0198308859082277	3.44336309316815	0.879651343356471	0.978820447958221	20:49982998-49988886:+	SNAI1	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001649,biological_process osteoblast differentiation;GO:0001707,biological_process mesoderm formation;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007498,biological_process mesoderm development;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010957,biological_process negative regulation of vitamin D biosynthetic process;GO:0016477,biological_process cell migration;GO:0019900,molecular_function kinase binding;GO:0030335,biological_process positive regulation of cell migration;GO:0031069,biological_process hair follicle morphogenesis;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0060021,biological_process palate development;GO:0060536,biological_process cartilage morphogenesis;GO:0060707,biological_process trophoblast giant cell differentiation;GO:0060806,biological_process negative regulation of cell differentiation involved in embryonic placenta development;GO:0060972,biological_process left/right pattern formation;GO:0061314,biological_process Notch signaling involved in heart development;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2000810,biological_process regulation of bicellular tight junction assembly	SNAI1; snail 1; K05707	snail family transcriptional repressor 1 [Source:HGNC Symbol%3BAcc:HGNC:11128]
ENSG00000178700	6.80	4.77	6.82	4.80	7.03	6.39	0.044105263806809	1.85058298578097	0.879700388094894	0.978820447958221	3:94047835-94063389:-	DHFR2	15;GO:0003729,molecular_function mRNA binding;GO:0004146,molecular_function dihydrofolate reductase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006545,biological_process glycine biosynthetic process;GO:0006730,biological_process one-carbon metabolic process;GO:0009165,biological_process nucleotide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0046105,biological_process thymidine biosynthetic process;GO:0046653,biological_process tetrahydrofolate metabolic process;GO:0046654,biological_process tetrahydrofolate biosynthetic process;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process	DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]; K00287	dihydrofolate reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:27309]
ENSG00000147044	38.29	35.22	41.42	40.03	35.07	41.83	-0.0117968498682931	6.76733907731059	0.880033954939527	0.978976175598298	X:41514933-41923463:-	CASK	40;GO:0000166,molecular_function nucleotide binding;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0004385,molecular_function guanylate kinase activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005604,cellular_component basement membrane;GO:0005634,cellular_component nucleus;GO:0005652,cellular_component nuclear lamina;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007155,biological_process cell adhesion;GO:0007269,biological_process neurotransmitter secretion;GO:0010839,biological_process negative regulation of keratinocyte proliferation;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016363,cellular_component nuclear matrix;GO:0016740,molecular_function transferase activity;GO:0031982,cellular_component vesicle;GO:0042043,molecular_function neurexin family protein binding;GO:0042734,cellular_component presynaptic membrane;GO:0045202,cellular_component synapse;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046037,biological_process GMP metabolic process;GO:0046710,biological_process GDP metabolic process;GO:0060170,cellular_component ciliary membrane;GO:0061045,biological_process negative regulation of wound healing;GO:0070509,biological_process calcium ion import;GO:0090280,biological_process positive regulation of calcium ion import;GO:0090288,biological_process negative regulation of cellular response to growth factor stimulus	NA	calcium/calmodulin dependent serine protein kinase [Source:HGNC Symbol%3BAcc:HGNC:1497]
ENSG00000164024	58.26	59.58	58.22	58.67	60.25	59.75	-0.0103112603997119	6.1655695071607	0.880062627783121	0.978976175598298	4:98995619-99062813:+	METAP1	13;GO:0004177,molecular_function aminopeptidase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0018206,biological_process peptidyl-methionine modification;GO:0022400,biological_process regulation of rhodopsin mediated signaling pathway;GO:0031365,biological_process N-terminal protein amino acid modification;GO:0046872,molecular_function metal ion binding;GO:0070527,biological_process platelet aggregation	NA	methionyl aminopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:15789]
ENSG00000174013	6.59	6.24	4.80	6.54	4.68	6.97	-0.0404049718955562	2.40072978049145	0.880081662573456	0.978976175598298	3:196568610-196589059:+	FBXO45	21;GO:0001764,biological_process neuron migration;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0021799,biological_process cerebral cortex radially oriented cell migration;GO:0021800,biological_process cerebral cortex tangential migration;GO:0021957,biological_process corticospinal tract morphogenesis;GO:0021960,biological_process anterior commissure morphogenesis;GO:0030054,cellular_component cell junction;GO:0042734,cellular_component presynaptic membrane;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0060384,biological_process innervation;GO:0060386,biological_process synapse assembly involved in innervation	NA	F-box protein 45 [Source:HGNC Symbol%3BAcc:HGNC:29148]
ENSG00000138380	5.34	4.93	6.02	5.08	5.61	6.00	-0.0162459740628118	3.67393802005938	0.880155814039878	0.978976175598298	2:202912213-202987063:+	CARF	14;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0035865,biological_process cellular response to potassium ion;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0061400,biological_process positive regulation of transcription from RNA polymerase II promoter in response to calcium ion;GO:0071277,biological_process cellular response to calcium ion	NA	calcium responsive transcription factor [Source:HGNC Symbol%3BAcc:HGNC:14435]
ENSG00000153904	17.53	15.70	16.21	17.71	16.88	15.98	-0.0148665980813386	3.85630093227238	0.880350897667413	0.979105428971023	1:85318480-85578363:-	DDAH1	19;GO:0000052,biological_process citrulline metabolic process;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0003824,molecular_function catalytic activity;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006525,biological_process arginine metabolic process;GO:0006527,biological_process arginine catabolic process;GO:0007263,biological_process nitric oxide mediated signal transduction;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016403,molecular_function dimethylargininase activity;GO:0016597,molecular_function amino acid binding;GO:0016787,molecular_function hydrolase activity;GO:0043116,biological_process negative regulation of vascular permeability;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046872,molecular_function metal ion binding;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0070062,cellular_component extracellular exosome;GO:1900038,biological_process negative regulation of cellular response to hypoxia	NA	dimethylarginine dimethylaminohydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:2715]
ENSG00000140961	8.06	7.83	7.60	7.42	8.18	7.81	0.0173251245586302	3.92856839357904	0.880495456695671	0.979135140089792	16:83948281-83966332:+	OSGIN1	10;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0007275,biological_process multicellular organism development;GO:0008083,molecular_function growth factor activity;GO:0016491,molecular_function oxidoreductase activity;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0040008,biological_process regulation of growth;GO:0043065,biological_process positive regulation of apoptotic process;GO:0055114,biological_process oxidation-reduction process	NA	oxidative stress induced growth inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:30093]
ENSG00000183624	31.19	28.62	32.78	29.96	31.99	30.72	0.015343864494122	5.04462226620808	0.88053537169277	0.979135140089792	3:129278827-129306186:+	HMCES	4;GO:0003677,molecular_function DNA binding;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity	NA	5-hydroxymethylcytosine binding%2C ES cell specific [Source:HGNC Symbol%3BAcc:HGNC:24446]
ENSG00000178974	17.71	17.74	18.39	17.59	19.09	18.07	-0.0112336672463832	5.27744168857887	0.880637210739633	0.979160667942589	14:55271302-55361918:+	FBXO34	1;GO:0005515,molecular_function protein binding	NA	F-box protein 34 [Source:HGNC Symbol%3BAcc:HGNC:20201]
ENSG00000146410	7.60	8.02	6.34	7.65	7.64	7.13	-0.0251878515696165	3.29673015201018	0.88079148253547	0.979244484792905	6:136231023-136250335:-	MTFR2	5;GO:0000266,biological_process mitochondrial fission;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0007005,biological_process mitochondrion organization;GO:0009060,biological_process aerobic respiration	NA	mitochondrial fission regulator 2 [Source:HGNC Symbol%3BAcc:HGNC:21115]
ENSG00000099341	96.36	102.82	100.85	101.02	96.13	103.21	0.00920694147440966	7.11486786868072	0.880959403601377	0.979343460227824	19:38374535-38383824:+	PSMD8	36;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008541,cellular_component proteasome regulatory particle, lid subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0022624,cellular_component proteasome accessory complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031647,biological_process regulation of protein stability;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043248,biological_process proteasome assembly;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	PSMD8, RPN12; 26S proteasome regulatory subunit N12; K03031	proteasome 26S subunit%2C non-ATPase 8 [Source:HGNC Symbol%3BAcc:HGNC:9566]
ENSG00000102178	22.64	24.81	23.91	22.83	21.62	26.43	0.015042620133786	4.07588427243318	0.881073368334778	0.979382441223211	X:154483716-154486670:-	UBL4A	11;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0019787,molecular_function ubiquitin-like protein transferase activity;GO:0051087,molecular_function chaperone binding;GO:0071816,biological_process tail-anchored membrane protein insertion into ER membrane;GO:0071818,cellular_component BAT3 complex	NA	ubiquitin like 4A [Source:HGNC Symbol%3BAcc:HGNC:12505]
ENSG00000170185	8.51	7.15	7.32	7.63	7.48	8.34	-0.0130473566141239	4.66355269416003	0.881292992302649	0.979389434722489	4:143184916-143223830:+	USP38	8;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 38 [Source:HGNC Symbol%3BAcc:HGNC:20067]
ENSG00000089057	11.88	10.63	13.59	13.86	10.66	12.40	-0.0159288248093414	4.58284546856517	0.881346239908379	0.979389434722489	20:4852355-5010293:-	SLC23A2	28;GO:0005215,molecular_function transporter activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006979,biological_process response to oxidative stress;GO:0008520,molecular_function L-ascorbate:sodium symporter activity;GO:0008523,molecular_function sodium-dependent multivitamin transmembrane transporter activity;GO:0009925,cellular_component basal plasma membrane;GO:0015205,molecular_function nucleobase transmembrane transporter activity;GO:0015229,molecular_function L-ascorbic acid transporter activity;GO:0015293,molecular_function symporter activity;GO:0015851,biological_process nucleobase transport;GO:0015882,biological_process L-ascorbic acid transport;GO:0015993,biological_process molecular hydrogen transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019852,biological_process L-ascorbic acid metabolic process;GO:0035461,biological_process vitamin transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0070890,molecular_function sodium-dependent L-ascorbate transmembrane transporter activity;GO:0070904,biological_process transepithelial L-ascorbic acid transport;GO:1905039,biological_process carboxylic acid transmembrane transport	SLC23A1, SVCT1; solute carrier family 23 (nucleobase transporter), member 1; K14611	solute carrier family 23 member 2 [Source:HGNC Symbol%3BAcc:HGNC:10973]
ENSG00000173889	7.53	5.54	7.71	7.98	6.64	6.68	-0.0146825802852226	4.50047757505657	0.88138251113224	0.979389434722489	3:170086731-170181749:-	PHC3	9;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex;GO:0046872,molecular_function metal ion binding	NA	polyhomeotic homolog 3 [Source:HGNC Symbol%3BAcc:HGNC:15682]
ENSG00000101986	8.22	8.36	9.42	9.21	8.66	8.06	0.0179736082903895	4.38223094604219	0.88139526103963	0.979389434722489	X:153724867-153744762:+	ABCD1	31;GO:0000166,molecular_function nucleotide binding;GO:0005215,molecular_function transporter activity;GO:0005324,molecular_function long-chain fatty acid transporter activity;GO:0005325,molecular_function peroxisomal fatty-acyl-CoA transporter activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0007031,biological_process peroxisome organization;GO:0015910,biological_process peroxisomal long-chain fatty acid import;GO:0015919,biological_process peroxisomal membrane transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016887,molecular_function ATPase activity;GO:0019899,molecular_function enzyme binding;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042758,biological_process long-chain fatty acid catabolic process;GO:0042760,biological_process very long-chain fatty acid catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043651,biological_process linoleic acid metabolic process;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055085,biological_process transmembrane transport	ABCD1, ALD; ATP-binding cassette, subfamily D (ALD), member 1; K05675	ATP binding cassette subfamily D member 1 [Source:HGNC Symbol%3BAcc:HGNC:61]
ENSG00000124160	12.48	13.59	15.13	12.85	14.37	14.78	-0.016408191336635	4.60013872090179	0.881788321285232	0.979733574721044	20:46060984-46089952:-	NCOA5	10;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0015629,cellular_component actin cytoskeleton;GO:0042593,biological_process glucose homeostasis;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway	NA	nuclear receptor coactivator 5 [Source:HGNC Symbol%3BAcc:HGNC:15909]
ENSG00000218739	60.03	45.79	62.25	63.02	56.88	52.74	-0.0141682026669704	3.79224239972969	0.881862823681481	0.979733574721044	2:37196487-37216193:+	CEBPZOS	4;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane	NA	CEBPZ opposite strand [Source:HGNC Symbol%3BAcc:HGNC:49288]
ENSG00000162341	4.87	4.03	5.46	4.85	5.17	4.31	0.0270438755067388	3.51407547324015	0.882079052647901	0.979832119614096	11:69048896-69162440:+	TPCN2	29;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006939,biological_process smooth muscle contraction;GO:0007040,biological_process lysosome organization;GO:0010008,cellular_component endosome membrane;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019722,biological_process calcium-mediated signaling;GO:0019901,molecular_function protein kinase binding;GO:0033280,biological_process response to vitamin D;GO:0034220,biological_process ion transmembrane transport;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042802,molecular_function identical protein binding;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0072345,molecular_function NAADP-sensitive calcium-release channel activity;GO:0086010,biological_process membrane depolarization during action potential	TPCN2; two pore calcium channel protein 2; K14077	two pore segment channel 2 [Source:HGNC Symbol%3BAcc:HGNC:20820]
ENSG00000056050	16.19	18.05	18.15	16.37	17.17	18.56	0.014677554791901	4.18784497434963	0.882109396333483	0.979832119614096	4:169729464-169757953:-	HPF1	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010835,biological_process regulation of protein ADP-ribosylation;GO:0018312,biological_process peptidyl-serine ADP-ribosylation;GO:0042393,molecular_function histone binding	NA	histone PARylation factor 1 [Source:HGNC Symbol%3BAcc:HGNC:26051]
ENSG00000166908	10.96	13.85	10.90	11.62	12.91	11.80	-0.0247973428597165	3.93100178268701	0.882239706814484	0.979887680790839	12:57591173-57603418:+	PIP4K2C	19;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0010506,biological_process regulation of autophagy;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016307,molecular_function phosphatidylinositol phosphate kinase activity;GO:0016309,molecular_function 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0042802,molecular_function identical protein binding;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0070062,cellular_component extracellular exosome;GO:2000786,biological_process positive regulation of autophagosome assembly	PIP4K2; 1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]; K00920	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [Source:HGNC Symbol%3BAcc:HGNC:23786]
ENSG00000169228	44.87	42.62	50.91	46.99	49.37	44.79	-0.0115777429020362	4.90587454043785	0.882317297043358	0.979887680790839	5:177301197-177303744:-	RAB24	15;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030667,cellular_component secretory granule membrane;GO:0043312,biological_process neutrophil degranulation	NA	RAB24%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9765]
ENSG00000157017	2.49	3.16	2.43	5.11	1.17	2.32	-0.0911032382685452	0.492123788110617	0.882497684205536	0.979987745109358	3:10285674-10292947:-	GHRL	73;GO:0000187,biological_process activation of MAPK activity;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001696,biological_process gastric acid secretion;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0005179,molecular_function hormone activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0006006,biological_process glucose metabolic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0008154,biological_process actin polymerization or depolymerization;GO:0008343,biological_process adult feeding behavior;GO:0009725,biological_process response to hormone;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0016358,biological_process dendrite development;GO:0016525,biological_process negative regulation of angiogenesis;GO:0016608,molecular_function growth hormone-releasing hormone activity;GO:0030252,biological_process growth hormone secretion;GO:0030296,molecular_function protein tyrosine kinase activator activity;GO:0030424,cellular_component axon;GO:0031667,biological_process response to nutrient levels;GO:0031768,molecular_function ghrelin receptor binding;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032095,biological_process regulation of response to food;GO:0032097,biological_process positive regulation of response to food;GO:0032100,biological_process positive regulation of appetite;GO:0032691,biological_process negative regulation of interleukin-1 beta production;GO:0034774,cellular_component secretory granule lumen;GO:0035483,biological_process gastric emptying;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0040010,biological_process positive regulation of growth rate;GO:0040013,biological_process negative regulation of locomotion;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042127,biological_process regulation of cell proliferation;GO:0042322,biological_process negative regulation of circadian sleep/wake cycle, REM sleep;GO:0042536,biological_process negative regulation of tumor necrosis factor biosynthetic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043400,biological_process cortisol secretion;GO:0043627,biological_process response to estrogen;GO:0045409,biological_process negative regulation of interleukin-6 biosynthetic process;GO:0045927,biological_process positive regulation of growth;GO:0046010,biological_process positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0046676,biological_process negative regulation of insulin secretion;GO:0046697,biological_process decidualization;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051216,biological_process cartilage development;GO:0051461,biological_process positive regulation of corticotropin secretion;GO:0051464,biological_process positive regulation of cortisol secretion;GO:0051602,biological_process response to electrical stimulus;GO:0051965,biological_process positive regulation of synapse assembly;GO:0051969,biological_process regulation of transmission of nerve impulse;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060124,biological_process positive regulation of growth hormone secretion;GO:0060399,biological_process positive regulation of growth hormone receptor signaling pathway;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0098794,cellular_component postsynapse;GO:0120058,Biological_Process positive regulation of small intestinal transit;GO:1903012,biological_process positive regulation of bone development;GO:1903672,biological_process positive regulation of sprouting angiogenesis;GO:1904000,biological_process positive regulation of eating behavior;GO:1904179,biological_process positive regulation of adipose tissue development;GO:1904306,biological_process positive regulation of gastro-intestinal system smooth muscle contraction;GO:1904346,biological_process positive regulation of gastric mucosal blood circulation;GO:1904349,biological_process positive regulation of small intestine smooth muscle contraction;GO:1904468,biological_process negative regulation of tumor necrosis factor secretion;GO:1905333,biological_process regulation of gastric motility;GO:1905564,biological_process positive regulation of vascular endothelial cell proliferation;GO:2000253,biological_process positive regulation of feeding behavior;GO:2000506,biological_process negative regulation of energy homeostasis;GO:2000507,biological_process positive regulation of energy homeostasis	GHRL; ghrelin; K05254	ghrelin and obestatin prepropeptide [Source:HGNC Symbol%3BAcc:HGNC:18129]
ENSG00000100575	139.14	118.47	128.18	137.97	114.47	140.90	-0.0130063138572406	5.12580401712512	0.882565294657014	0.979987745109358	14:58408493-58427614:-	TIMM9	19;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006626,biological_process protein targeting to mitochondrion;GO:0006810,biological_process transport;GO:0007605,biological_process sensory perception of sound;GO:0008270,molecular_function zinc ion binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0042719,cellular_component mitochondrial intermembrane space protein transporter complex;GO:0042721,cellular_component mitochondrial inner membrane protein insertion complex;GO:0042803,molecular_function protein homodimerization activity;GO:0045039,biological_process protein import into mitochondrial inner membrane;GO:0046872,molecular_function metal ion binding;GO:0051087,molecular_function chaperone binding;GO:0072321,biological_process chaperone-mediated protein transport	NA	translocase of inner mitochondrial membrane 9 [Source:HGNC Symbol%3BAcc:HGNC:11819]
ENSG00000196976	17.29	14.70	16.47	18.15	16.62	15.08	-0.0179113156731434	2.84872040691921	0.882938671780417	0.980266609762632	X:154477768-154479257:-	LAGE3	9;GO:0000408,cellular_component EKC/KEOPS complex;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0008033,biological_process tRNA processing;GO:0008150,biological_process biological_process;GO:0016604,cellular_component nuclear body	NA	L antigen family member 3 [Source:HGNC Symbol%3BAcc:HGNC:26058]
ENSG00000144785	1.79	2.79	1.96	1.52	2.69	2.58	-0.0747396798038194	0.917216091667143	0.883026513962967	0.980266609762632	12:56285915-56316059:-	AC073896.1	3;GO:0005783,cellular_component endoplasmic reticulum;GO:0007167,biological_process enzyme linked receptor protein signaling pathway;GO:0009888,biological_process tissue development	CS, gltA; citrate synthase [EC:2.3.3.1]; K01647	NA
ENSG00000214944	10.19	10.91	9.65	9.69	10.18	11.35	-0.0139446781402885	5.77398961608662	0.883053349743475	0.980266609762632	5:73626157-73941993:+	ARHGEF28	13;GO:0003723,molecular_function RNA binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway	NA	Rho guanine nucleotide exchange factor 28 [Source:HGNC Symbol%3BAcc:HGNC:30322]
ENSG00000172046	17.65	17.31	17.74	18.01	18.68	16.84	-0.00951041883316868	6.2799193370508	0.883534205489449	0.980693898537101	3:49108045-49120938:-	USP19	29;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0048642,biological_process negative regulation of skeletal muscle tissue development;GO:0050821,biological_process protein stabilization;GO:0051879,molecular_function Hsp90 protein binding;GO:0071108,biological_process protein K48-linked deubiquitination;GO:0090068,biological_process positive regulation of cell cycle process;GO:1900037,biological_process regulation of cellular response to hypoxia;GO:1901799,biological_process negative regulation of proteasomal protein catabolic process;GO:1904292,biological_process regulation of ERAD pathway;GO:1990380,molecular_function Lys48-specific deubiquitinase activity	NA	ubiquitin specific peptidase 19 [Source:HGNC Symbol%3BAcc:HGNC:12617]
ENSG00000132950	5.28	5.74	6.61	5.84	5.31	6.35	0.020961126465731	3.64954379777315	0.883596274972926	0.980693898537101	13:19823481-19863636:-	ZMYM5	14;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0022604,biological_process regulation of cell morphogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger MYM-type containing 5 [Source:HGNC Symbol%3BAcc:HGNC:13029]
ENSG00000204060	1.58	0.84	0.75	1.22	1.28	0.86	-0.0437637436876582	0.825835945863076	0.883772702227909	0.98072038372119	1:41361921-41383590:+	FOXO6	14;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007613,biological_process memory;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0060999,biological_process positive regulation of dendritic spine development	NA	forkhead box O6 [Source:HGNC Symbol%3BAcc:HGNC:24814]
ENSG00000001631	34.35	33.90	34.94	33.03	35.93	34.40	0.0101168828349048	6.25335251331364	0.883932060967174	0.98072038372119	7:92198968-92246166:-	KRIT1	24;GO:0001525,biological_process angiogenesis;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008017,molecular_function microtubule binding;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0016020,cellular_component membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030054,cellular_component cell junction;GO:0030695,molecular_function GTPase regulator activity;GO:0032092,biological_process positive regulation of protein binding;GO:0032403,molecular_function protein complex binding;GO:0043234,cellular_component protein complex;GO:0045454,biological_process cell redox homeostasis;GO:0050790,biological_process regulation of catalytic activity;GO:2000114,biological_process regulation of establishment of cell polarity;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	NA	KRIT1%2C ankyrin repeat containing [Source:HGNC Symbol%3BAcc:HGNC:1573]
ENSG00000159459	4.50	4.52	4.83	4.42	4.79	4.89	-0.0134362672953455	4.65434533372601	0.88398789775597	0.98072038372119	15:42942896-43106113:-	UBR1	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000502,cellular_component proteasome complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030163,biological_process protein catabolic process;GO:0032007,biological_process negative regulation of TOR signaling;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070728,molecular_function leucine binding;GO:0071233,biological_process cellular response to leucine;GO:0071596,biological_process ubiquitin-dependent protein catabolic process via the N-end rule pathway	NA	ubiquitin protein ligase E3 component n-recognin 1 [Source:HGNC Symbol%3BAcc:HGNC:16808]
ENSG00000041988	12.16	9.14	11.71	12.76	9.43	11.74	-0.0185262782288001	3.70750043530785	0.884024328012135	0.98072038372119	1:6624865-6635586:+	THAP3	4;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0046872,molecular_function metal ion binding	NA	THAP domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:20855]
ENSG00000185344	6.67	6.52	6.87	7.38	6.09	6.54	0.0176923839215461	4.16864718746018	0.884074348103232	0.98072038372119	12:123712317-123761755:+	ATP6V0A2	30;GO:0000220,cellular_component vacuolar proton-transporting V-type ATPase, V0 domain;GO:0001669,cellular_component acrosomal vesicle;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006955,biological_process immune response;GO:0007035,biological_process vacuolar acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015986,biological_process ATP synthesis coupled proton transport;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0036295,biological_process cellular response to increased oxygen levels;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0051117,molecular_function ATPase binding;GO:0070072,biological_process vacuolar proton-transporting V-type ATPase complex assembly;GO:0090383,biological_process phagosome acidification	ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a; K02154	ATPase H+ transporting V0 subunit a2 [Source:HGNC Symbol%3BAcc:HGNC:18481]
ENSG00000175221	23.77	22.57	22.46	23.82	22.43	22.66	0.0104620735390963	6.1045449540625	0.884128256363791	0.98072038372119	19:867629-893218:-	MED16	21;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003824,molecular_function catalytic activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016592,cellular_component mediator complex;GO:0030375,molecular_function thyroid hormone receptor coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046966,molecular_function thyroid hormone receptor binding;GO:2000273,biological_process positive regulation of receptor activity	MED16; mediator of RNA polymerase II transcription subunit 16; K15159	mediator complex subunit 16 [Source:HGNC Symbol%3BAcc:HGNC:17556]
ENSG00000204257	7.72	6.46	7.05	6.62	8.05	6.44	0.0305258127670439	2.79729217293356	0.884217752339279	0.98072038372119	6:32948612-32969094:-	HLA-DMA	17;GO:0002376,biological_process immune system process;GO:0002503,biological_process peptide antigen assembly with MHC class II protein complex;GO:0002504,biological_process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006955,biological_process immune response;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019882,biological_process antigen processing and presentation;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0023026,molecular_function MHC class II protein complex binding;GO:0031902,cellular_component late endosome membrane;GO:0042613,cellular_component MHC class II protein complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome	MHC2; MHC class II antigen; K06752	major histocompatibility complex%2C class II%2C DM alpha [Source:HGNC Symbol%3BAcc:HGNC:4934]
ENSG00000021776	13.19	15.17	12.33	12.85	14.62	13.86	-0.0145866056263893	5.99016787904285	0.884266045321395	0.98072038372119	15:34851781-34969839:-	AQR	11;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0071013,cellular_component catalytic step 2 spliceosome	AQR; intron-binding protein aquarius; K12874	aquarius intron-binding spliceosomal factor [Source:HGNC Symbol%3BAcc:HGNC:29513]
ENSG00000133835	51.17	60.97	49.59	49.63	58.79	53.09	0.0119914687888966	7.06643930704066	0.884419268643767	0.98072038372119	5:119452442-119637199:+	HSD17B4	28;GO:0000038,biological_process very long-chain fatty acid metabolic process;GO:0001649,biological_process osteoblast differentiation;GO:0003857,molecular_function 3-hydroxyacyl-CoA dehydrogenase activity;GO:0005102,molecular_function receptor binding;GO:0005739,cellular_component mitochondrion;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005782,cellular_component peroxisomal matrix;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006699,biological_process bile acid biosynthetic process;GO:0008209,biological_process androgen metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016508,molecular_function long-chain-enoyl-CoA hydratase activity;GO:0016829,molecular_function lyase activity;GO:0016853,molecular_function isomerase activity;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0033989,molecular_function 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity;GO:0036109,biological_process alpha-linolenic acid metabolic process;GO:0036111,biological_process very long-chain fatty-acyl-CoA metabolic process;GO:0036112,biological_process medium-chain fatty-acyl-CoA metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0044594,molecular_function 17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0055114,biological_process oxidation-reduction process;GO:0060009,biological_process Sertoli cell development	HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]; K12405	hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol%3BAcc:HGNC:5213]
ENSG00000105976	110.08	101.54	111.54	109.10	102.69	111.96	0.00952317623645293	8.87606022053397	0.88443229396891	0.98072038372119	7:116672389-116798386:+	MET	50;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001886,biological_process endothelial cell morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005008,molecular_function hepatocyte growth factor-activated receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283,biological_process cell proliferation;GO:0009925,cellular_component basal plasma membrane;GO:0009986,cellular_component cell surface;GO:0010507,biological_process negative regulation of autophagy;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017154,molecular_function semaphorin receptor activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019903,molecular_function protein phosphatase binding;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:0035635,biological_process entry of bacterium into host cell;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048012,biological_process hepatocyte growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0050918,biological_process positive chemotaxis;GO:0051497,biological_process negative regulation of stress fiber assembly;GO:0061436,biological_process establishment of skin barrier;GO:0070495,biological_process negative regulation of thrombin receptor signaling pathway;GO:0071526,biological_process semaphorin-plexin signaling pathway;GO:1901299,biological_process negative regulation of hydrogen peroxide-mediated programmed cell death;GO:1905098,biological_process negative regulation of guanyl-nucleotide exchange factor activity;GO:2001028,biological_process positive regulation of endothelial cell chemotaxis	MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]; K05099	MET proto-oncogene%2C receptor tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:7029]
ENSG00000262919	10.29	11.62	8.80	10.44	10.41	10.47	-0.0279406317999137	3.31930916425754	0.884495067399703	0.98072038372119	X:153587918-153600045:-	FAM58A	10;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0030295,molecular_function protein kinase activator activity;GO:0032147,biological_process activation of protein kinase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1901409,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain	NA	family with sequence similarity 58 member A [Source:HGNC Symbol%3BAcc:HGNC:28434]
ENSG00000174945	13.57	12.28	14.09	14.48	11.22	15.11	-0.0168423311111017	4.3452384125297	0.884568228159385	0.98072038372119	7:2679521-2775500:+	AMZ1	7;GO:0005575,cellular_component cellular_component;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	archaelysin family metallopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:22231]
ENSG00000140992	6.43	8.24	8.02	7.76	8.15	6.62	0.0166675581556896	3.8427796985406	0.884722706873909	0.980793396407247	16:2537963-2603188:+	PDPK1	62;GO:0000166,molecular_function nucleotide binding;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0003323,biological_process type B pancreatic cell development;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004676,molecular_function 3-phosphoinositide-dependent protein kinase activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006972,biological_process hyperosmotic response;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0010518,biological_process positive regulation of phospholipase activity;GO:0010594,biological_process regulation of endothelial cell migration;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0014069,cellular_component postsynaptic density;GO:0016004,molecular_function phospholipase activator activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019722,biological_process calcium-mediated signaling;GO:0019901,molecular_function protein kinase binding;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030168,biological_process platelet activation;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031295,biological_process T cell costimulation;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032148,biological_process activation of protein kinase B activity;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034122,biological_process negative regulation of toll-like receptor signaling pathway;GO:0035556,biological_process intracellular signal transduction;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042995,cellular_component cell projection;GO:0043122,biological_process regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043204,cellular_component perikaryon;GO:0043274,molecular_function phospholipase binding;GO:0043304,biological_process regulation of mast cell degranulation;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046777,biological_process protein autophosphorylation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048041,biological_process focal adhesion assembly;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1990416,biological_process cellular response to brain-derived neurotrophic factor stimulus	PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]; K06276	3-phosphoinositide dependent protein kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:8816]
ENSG00000261740	5.97	4.21	6.74	4.95	7.03	4.73	0.0494991921215616	2.32878504341741	0.884836392926964	0.980793396407247	16:29443229-29454651:-	BOLA2-SMG1P6	NA	NA	BOLA2-SMG1P6 readthrough [Source:HGNC Symbol%3BAcc:HGNC:53563]
ENSG00000145040	6.31	4.27	6.35	5.13	5.64	7.12	-0.0469636431203627	1.08826380413951	0.884871122723335	0.980793396407247	3:48561726-48563773:-	UCN2	12;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0005102,molecular_function receptor binding;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006171,biological_process cAMP biosynthetic process;GO:0006950,biological_process response to stress;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007586,biological_process digestion;GO:0031669,biological_process cellular response to nutrient levels;GO:0042562,molecular_function hormone binding;GO:0051431,molecular_function corticotropin-releasing hormone receptor 2 binding	UCN2_3; urocortin 2/3; K05257	urocortin 2 [Source:HGNC Symbol%3BAcc:HGNC:18414]
ENSG00000083168	5.49	4.50	5.13	5.30	4.53	5.28	0.0170494699872055	4.98658734030142	0.88515816686243	0.980965482894347	8:41929478-42051990:-	KAT6A	33;GO:0000786,cellular_component nucleosome;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006323,biological_process DNA packaging;GO:0006334,biological_process nucleosome assembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006473,biological_process protein acetylation;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0016407,molecular_function acetyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016573,biological_process histone acetylation;GO:0016605,cellular_component PML body;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0016747,molecular_function transferase activity, transferring acyl groups other than amino-acyl groups;GO:0030099,biological_process myeloid cell differentiation;GO:0043966,biological_process histone H3 acetylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048513,biological_process animal organ development;GO:0070776,cellular_component MOZ/MORF histone acetyltransferase complex;GO:0090398,biological_process cellular senescence;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	MYST3, KAT6A; histone acetyltransferase MYST3 [EC:2.3.1.48]; K11305	lysine acetyltransferase 6A [Source:HGNC Symbol%3BAcc:HGNC:13013]
ENSG00000168615	162.63	171.66	160.48	157.16	172.15	166.36	0.00891831893691208	8.75565486614053	0.885232056192341	0.980965482894347	8:38996868-39105144:+	ADAM9	46;GO:0000186,biological_process activation of MAPKK activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0009986,cellular_component cell surface;GO:0010042,biological_process response to manganese ion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016477,biological_process cell migration;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030216,biological_process keratinocyte differentiation;GO:0031233,cellular_component intrinsic component of external side of plasma membrane;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0033631,biological_process cell-cell adhesion mediated by integrin;GO:0034241,biological_process positive regulation of macrophage fusion;GO:0034612,biological_process response to tumor necrosis factor;GO:0034616,biological_process response to laminar fluid shear stress;GO:0042117,biological_process monocyte activation;GO:0042542,biological_process response to hydrogen peroxide;GO:0043236,molecular_function laminin binding;GO:0046872,molecular_function metal ion binding;GO:0050714,biological_process positive regulation of protein secretion;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0051088,biological_process PMA-inducible membrane protein ectodomain proteolysis;GO:0051384,biological_process response to glucocorticoid;GO:0051549,biological_process positive regulation of keratinocyte migration;GO:0051592,biological_process response to calcium ion;GO:0070062,cellular_component extracellular exosome;GO:0071222,biological_process cellular response to lipopolysaccharide	NA	ADAM metallopeptidase domain 9 [Source:HGNC Symbol%3BAcc:HGNC:216]
ENSG00000109854	87.37	82.74	91.44	89.13	84.95	87.97	0.0108075190306645	6.3377498552373	0.885263460838031	0.980965482894347	11:20363684-20383783:+	HTATIP2	18;GO:0001525,biological_process angiogenesis;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016491,molecular_function oxidoreductase activity;GO:0030154,biological_process cell differentiation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045765,biological_process regulation of angiogenesis;GO:0051170,biological_process nuclear import;GO:0055114,biological_process oxidation-reduction process	NA	HIV-1 Tat interactive protein 2 [Source:HGNC Symbol%3BAcc:HGNC:16637]
ENSG00000128011	0.64	0.91	0.80	1.04	0.72	0.52	0.045409214879127	0.936779115403036	0.885400313241681	0.980991516117367	19:39306567-39315336:-	LRFN1	11;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007409,biological_process axonogenesis;GO:0009986,cellular_component cell surface;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane	NA	leucine rich repeat and fibronectin type III domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29290]
ENSG00000163528	26.10	26.30	27.05	27.06	23.36	30.76	-0.0216086413348985	3.72401841557727	0.885518482780903	0.980991516117367	3:14112076-14124870:-	CHCHD4	11;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0022417,biological_process protein maturation by protein folding;GO:0045041,biological_process protein import into mitochondrial intermembrane space;GO:0051084,biological_process 'de novo' posttranslational protein folding;GO:0055114,biological_process oxidation-reduction process	NA	coiled-coil-helix-coiled-coil-helix domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:26467]
ENSG00000132846	1.51	3.27	2.10	1.71	2.38	3.11	-0.0989482582211998	0.82759321317563	0.885529348224166	0.980991516117367	5:77072071-77087323:-	ZBED3	12;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	zinc finger BED-type containing 3 [Source:HGNC Symbol%3BAcc:HGNC:20711]
ENSG00000025293	10.85	11.38	11.82	11.14	11.84	11.61	-0.0120215180581592	5.16675316291381	0.88560551181764	0.980991516117367	20:35771973-35950381:+	PHF20	24;GO:0000123,cellular_component histone acetyltransferase complex;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016569,biological_process covalent chromatin modification;GO:0031965,cellular_component nuclear membrane;GO:0043981,biological_process histone H4-K5 acetylation;GO:0043982,biological_process histone H4-K8 acetylation;GO:0043984,biological_process histone H4-K16 acetylation;GO:0043995,molecular_function histone acetyltransferase activity (H4-K5 specific);GO:0043996,molecular_function histone acetyltransferase activity (H4-K8 specific);GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046972,molecular_function histone acetyltransferase activity (H4-K16 specific);GO:0071339,cellular_component MLL1 complex;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	PHD finger protein 20 [Source:HGNC Symbol%3BAcc:HGNC:16098]
ENSG00000198546	1.88	3.44	4.10	4.17	2.99	2.61	-0.0485691830970059	1.53137457179461	0.88574434799527	0.980991516117367	10:133308474-133313162:+	ZNF511	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 511 [Source:HGNC Symbol%3BAcc:HGNC:28445]
ENSG00000182685	1.74	2.24	2.93	2.10	2.40	2.22	0.048646563550584	1.06376571633367	0.885761130479614	0.980991516117367	16:2209252-2211950:-	BRICD5	5;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042127,biological_process regulation of cell proliferation	NA	BRICHOS domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:28309]
ENSG00000136011	0.21	0.19	0.15	0.26	0.08	0.25	-0.0837865397386303	0.719188078948495	0.88608070112348	0.981257894820748	12:103587272-103766727:+	STAB2	24;GO:0001525,biological_process angiogenesis;GO:0005041,molecular_function low-density lipoprotein receptor activity;GO:0005044,molecular_function scavenger receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005540,molecular_function hyaluronic acid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007155,biological_process cell adhesion;GO:0009897,cellular_component external side of plasma membrane;GO:0010468,biological_process regulation of gene expression;GO:0015035,molecular_function protein disulfide oxidoreductase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030169,molecular_function low-density lipoprotein particle binding;GO:0030193,biological_process regulation of blood coagulation;GO:0030214,biological_process hyaluronan catabolic process;GO:0030666,cellular_component endocytic vesicle membrane;GO:0042742,biological_process defense response to bacterium;GO:0055114,biological_process oxidation-reduction process	NA	stabilin 2 [Source:HGNC Symbol%3BAcc:HGNC:18629]
ENSG00000229833	7.36	4.31	7.41	5.20	7.11	7.81	-0.0361047105126406	1.0444938300851	0.886367936091567	0.981467461122685	19:7629736-7631956:+	PET100	6;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly;GO:0051082,molecular_function unfolded protein binding	NA	PET100 homolog [Source:HGNC Symbol%3BAcc:HGNC:40038]
ENSG00000144199	29.46	32.67	31.02	29.01	30.84	33.07	0.0102809603830059	4.87541933346798	0.886461335392918	0.981467461122685	2:97083582-97094882:-	FAHD2B	4;GO:0003824,molecular_function catalytic activity;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	fumarylacetoacetate hydrolase domain containing 2B [Source:HGNC Symbol%3BAcc:HGNC:25318]
ENSG00000011114	16.74	17.28	16.51	16.61	17.59	17.05	-0.0104227828229936	6.0053830701074	0.886567218230372	0.981467461122685	14:93237549-93333092:-	BTBD7	2;GO:0005634,cellular_component nucleus;GO:0007275,biological_process multicellular organism development	NA	BTB domain containing 7 [Source:HGNC Symbol%3BAcc:HGNC:18269]
ENSG00000176953	22.36	22.96	22.07	21.38	24.56	21.37	0.0129771159347521	4.82609114687695	0.88661525748746	0.981467461122685	16:28950806-28967097:+	NFATC2IP	6;GO:0001816,biological_process cytokine production;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016925,biological_process protein sumoylation;GO:0031386,molecular_function protein tag;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	nuclear factor of activated T-cells 2 interacting protein [Source:HGNC Symbol%3BAcc:HGNC:25906]
ENSG00000187742	21.47	20.81	20.25	21.07	21.17	20.39	0.0103037843972118	5.74501097191026	0.886757200120004	0.981467461122685	9:89318505-89359662:+	SECISBP2	13;GO:0001514,biological_process selenocysteine incorporation;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006412,biological_process translation;GO:0021756,biological_process striatum development;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0035368,molecular_function selenocysteine insertion sequence binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0048666,biological_process neuron development;GO:2000623,biological_process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	NA	SECIS binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:30972]
ENSG00000171862	23.54	22.57	27.14	24.28	21.91	26.97	0.0158102181493896	4.90075054167323	0.886807389828001	0.981467461122685	10:87863112-87971930:+	PTEN	159;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000287,molecular_function magnesium ion binding;GO:0001525,biological_process angiogenesis;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002902,biological_process regulation of B cell apoptotic process;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006915,biological_process apoptotic process;GO:0007270,biological_process neuron-neuron synaptic transmission;GO:0007399,biological_process nervous system development;GO:0007416,biological_process synapse assembly;GO:0007417,biological_process central nervous system development;GO:0007507,biological_process heart development;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0007611,biological_process learning or memory;GO:0007613,biological_process memory;GO:0007626,biological_process locomotory behavior;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0009749,biological_process response to glucose;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010033,biological_process response to organic substance;GO:0010035,biological_process response to inorganic substance;GO:0010043,biological_process response to zinc ion;GO:0010628,biological_process positive regulation of gene expression;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0010975,biological_process regulation of neuron projection development;GO:0010997,molecular_function anaphase-promoting complex binding;GO:0014067,biological_process negative regulation of phosphatidylinositol 3-kinase signaling;GO:0014070,biological_process response to organic cyclic compound;GO:0014823,biological_process response to activity;GO:0016311,biological_process dephosphorylation;GO:0016314,molecular_function phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0016324,cellular_component apical plasma membrane;GO:0016477,biological_process cell migration;GO:0016579,biological_process protein deubiquitination;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0021542,biological_process dentate gyrus development;GO:0021955,biological_process central nervous system neuron axonogenesis;GO:0030165,molecular_function PDZ domain binding;GO:0030336,biological_process negative regulation of cell migration;GO:0030534,biological_process adult behavior;GO:0031175,biological_process neuron projection development;GO:0031642,biological_process negative regulation of myelination;GO:0031647,biological_process regulation of protein stability;GO:0031658,biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0032228,biological_process regulation of synaptic transmission, GABAergic;GO:0032286,biological_process central nervous system myelin maintenance;GO:0032355,biological_process response to estradiol;GO:0032535,biological_process regulation of cellular component size;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033032,biological_process regulation of myeloid cell apoptotic process;GO:0033198,biological_process response to ATP;GO:0033555,biological_process multicellular organismal response to stress;GO:0035176,biological_process social behavior;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035749,cellular_component myelin sheath adaxonal region;GO:0036294,biological_process cellular response to decreased oxygen levels;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042493,biological_process response to drug;GO:0042711,biological_process maternal behavior;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043197,cellular_component dendritic spine;GO:0043220,cellular_component Schmidt-Lanterman incisure;GO:0043491,biological_process protein kinase B signaling;GO:0043542,biological_process endothelial cell migration;GO:0043647,biological_process inositol phosphate metabolic process;GO:0044320,biological_process cellular response to leptin stimulus;GO:0045211,cellular_component postsynaptic membrane;GO:0045471,biological_process response to ethanol;GO:0045475,biological_process locomotor rhythm;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045792,biological_process negative regulation of cell size;GO:0046621,biological_process negative regulation of organ growth;GO:0046685,biological_process response to arsenic-containing substance;GO:0046855,biological_process inositol phosphate dephosphorylation;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048679,biological_process regulation of axon regeneration;GO:0048681,biological_process negative regulation of axon regeneration;GO:0048738,biological_process cardiac muscle tissue development;GO:0048853,biological_process forebrain morphogenesis;GO:0048854,biological_process brain morphogenesis;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050765,biological_process negative regulation of phagocytosis;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050821,biological_process protein stabilization;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051548,biological_process negative regulation of keratinocyte migration;GO:0051717,molecular_function inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity;GO:0051726,biological_process regulation of cell cycle;GO:0051800,molecular_function phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060024,biological_process rhythmic synaptic transmission;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060074,biological_process synapse maturation;GO:0060134,biological_process prepulse inhibition;GO:0060179,biological_process male mating behavior;GO:0060291,biological_process long-term synaptic potentiation;GO:0060292,biological_process long term synaptic depression;GO:0060341,biological_process regulation of cellular localization;GO:0060736,biological_process prostate gland growth;GO:0060997,biological_process dendritic spine morphogenesis;GO:0061002,biological_process negative regulation of dendritic spine morphogenesis;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071257,biological_process cellular response to electrical stimulus;GO:0071361,biological_process cellular response to ethanol;GO:0071456,biological_process cellular response to hypoxia;GO:0090071,biological_process negative regulation of ribosome biogenesis;GO:0090344,biological_process negative regulation of cell aging;GO:0090394,biological_process negative regulation of excitatory postsynaptic potential;GO:0097105,biological_process presynaptic membrane assembly;GO:0097107,biological_process postsynaptic density assembly;GO:1901017,biological_process negative regulation of potassium ion transmembrane transporter activity;GO:1903690,biological_process negative regulation of wound healing, spreading of epidermal cells;GO:1903984,biological_process positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1904668,biological_process positive regulation of ubiquitin protein ligase activity;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990314,biological_process cellular response to insulin-like growth factor stimulus;GO:1990381,molecular_function ubiquitin-specific protease binding;GO:1990782,molecular_function protein tyrosine kinase binding;GO:2000060,biological_process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle;GO:2000272,biological_process negative regulation of receptor activity;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000808,biological_process negative regulation of synaptic vesicle clustering;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]; K01110	phosphatase and tensin homolog [Source:HGNC Symbol%3BAcc:HGNC:9588]
ENSG00000115526	3.26	3.78	3.34	3.64	2.94	4.12	-0.0453102964259955	2.14036762119749	0.886903286936461	0.981467461122685	2:100391859-100417656:-	CHST10	10;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0007155,biological_process cell adhesion;GO:0008146,molecular_function sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016051,biological_process carbohydrate biosynthetic process;GO:0016232,molecular_function HNK-1 sulfotransferase activity;GO:0016740,molecular_function transferase activity	CHST10; carbohydrate 3-sulfotransferase 10 [EC:2.8.2.-]; K09674	carbohydrate sulfotransferase 10 [Source:HGNC Symbol%3BAcc:HGNC:19650]
ENSG00000125731	1.79	1.11	2.39	1.65	1.59	1.98	0.0554808509012611	1.7556064357669	0.886968171892087	0.981467461122685	19:6752159-6767588:-	SH2D3A	8;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0007254,biological_process JNK cascade;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0009967,biological_process positive regulation of signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	SH2 domain containing 3A [Source:HGNC Symbol%3BAcc:HGNC:16885]
ENSG00000128000	5.70	6.65	6.35	6.25	6.31	6.04	0.0131547302903631	3.97080555630191	0.886981549897227	0.981467461122685	19:40028259-40056209:-	ZNF780B	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 780B [Source:HGNC Symbol%3BAcc:HGNC:33109]
ENSG00000103994	9.16	9.06	9.10	8.64	9.05	9.65	0.00990930008163532	5.73236877229952	0.887162981006388	0.981580718712211	15:42412822-42491123:-	ZNF106	9;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0008286,biological_process insulin receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 106 [Source:HGNC Symbol%3BAcc:HGNC:12886]
ENSG00000129355	8.79	13.24	13.15	11.58	10.36	12.57	0.0263902534145785	2.56297182620204	0.887439037596127	0.981652554267846	19:10566461-10569059:-	CDKN2D	27;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0004861,molecular_function cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007605,biological_process sensory perception of sound;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009411,biological_process response to UV;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030308,biological_process negative regulation of cell growth;GO:0032526,biological_process response to retinoic acid;GO:0033280,biological_process response to vitamin D;GO:0042326,biological_process negative regulation of phosphorylation;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0048102,biological_process autophagic cell death;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0097129,cellular_component cyclin D2-CDK4 complex;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1902807,biological_process negative regulation of cell cycle G1/S phase transition	CDKN2D, P19, INK4D; cyclin-dependent kinase inhibitor 2D; K06623	cyclin dependent kinase inhibitor 2D [Source:HGNC Symbol%3BAcc:HGNC:1790]
ENSG00000235750	1.40	2.40	2.82	2.97	2.41	1.67	-0.0848579184686003	0.897761555417406	0.887485072544588	0.981652554267846	1:175156986-175192999:-	KIAA0040	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	KIAA0040 [Source:HGNC Symbol%3BAcc:HGNC:28950]
ENSG00000105640	1512.84	1497.56	1489.17	1524.95	1474.62	1562.45	-0.00807318567943666	9.64039439602541	0.88750152341449	0.981652554267846	19:17859875-17864153:+	RPL18A	15;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0097327,biological_process response to antineoplastic agent	RP-L18Ae, RPL18A; large subunit ribosomal protein L18Ae; K02882	ribosomal protein L18a [Source:HGNC Symbol%3BAcc:HGNC:10311]
ENSG00000106686	1.70	1.25	1.61	1.75	1.60	1.49	-0.0505468627253236	1.21221858125413	0.887606823586069	0.981652554267846	9:4553385-4666674:-	SPATA6L	NA	NA	spermatogenesis associated 6 like [Source:HGNC Symbol%3BAcc:HGNC:25472]
ENSG00000132170	28.88	25.57	32.13	31.42	24.82	32.07	-0.0140105296527934	5.54484483454982	0.88762331983423	0.981652554267846	3:12287367-12434356:+	PPARG	116;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001890,biological_process placenta development;GO:0002674,biological_process negative regulation of acute inflammatory response;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0004955,molecular_function prostaglandin receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007507,biological_process heart development;GO:0007584,biological_process response to nutrient;GO:0008022,molecular_function protein C-terminus binding;GO:0008134,molecular_function transcription factor binding;GO:0008144,molecular_function drug binding;GO:0008217,biological_process regulation of blood pressure;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009409,biological_process response to cold;GO:0009612,biological_process response to mechanical stimulus;GO:0010033,biological_process response to organic substance;GO:0010742,biological_process macrophage derived foam cell differentiation;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010871,biological_process negative regulation of receptor biosynthetic process;GO:0010887,biological_process negative regulation of cholesterol storage;GO:0010891,biological_process negative regulation of sequestering of triglyceride;GO:0014070,biological_process response to organic cyclic compound;GO:0015909,biological_process long-chain fatty acid transport;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019395,biological_process fatty acid oxidation;GO:0019899,molecular_function enzyme binding;GO:0019903,molecular_function protein phosphatase binding;GO:0030224,biological_process monocyte differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0030331,molecular_function estrogen receptor binding;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0030855,biological_process epithelial cell differentiation;GO:0031000,biological_process response to caffeine;GO:0031100,biological_process organ regeneration;GO:0032526,biological_process response to retinoic acid;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032966,biological_process negative regulation of collagen biosynthetic process;GO:0033189,biological_process response to vitamin A;GO:0033613,molecular_function activating transcription factor binding;GO:0033993,biological_process response to lipid;GO:0035357,biological_process peroxisome proliferator activated receptor signaling pathway;GO:0035902,biological_process response to immobilization stress;GO:0042277,molecular_function peptide binding;GO:0042493,biological_process response to drug;GO:0042593,biological_process glucose homeostasis;GO:0042594,biological_process response to starvation;GO:0042752,biological_process regulation of circadian rhythm;GO:0042802,molecular_function identical protein binding;GO:0042953,biological_process lipoprotein transport;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043388,biological_process positive regulation of DNA binding;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043621,molecular_function protein self-association;GO:0043627,biological_process response to estrogen;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045087,biological_process innate immune response;GO:0045165,biological_process cell fate commitment;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045713,biological_process low-density lipoprotein particle receptor biosynthetic process;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046321,biological_process positive regulation of fatty acid oxidation;GO:0046872,molecular_function metal ion binding;GO:0046965,molecular_function retinoid X receptor binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048469,biological_process cell maturation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048511,biological_process rhythmic process;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0048714,biological_process positive regulation of oligodendrocyte differentiation;GO:0050544,molecular_function arachidonic acid binding;GO:0050692,molecular_function DBD domain binding;GO:0050693,molecular_function LBD domain binding;GO:0050872,biological_process white fat cell differentiation;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051393,molecular_function alpha-actinin binding;GO:0051974,biological_process negative regulation of telomerase activity;GO:0055088,biological_process lipid homeostasis;GO:0055098,biological_process response to low-density lipoprotein particle;GO:0060100,biological_process positive regulation of phagocytosis, engulfment;GO:0060336,biological_process negative regulation of interferon-gamma-mediated signaling pathway;GO:0060694,biological_process regulation of cholesterol transporter activity;GO:0060850,biological_process regulation of transcription involved in cell fate commitment;GO:0071300,biological_process cellular response to retinoic acid;GO:0071306,biological_process cellular response to vitamin E;GO:0071379,biological_process cellular response to prostaglandin stimulus;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071455,biological_process cellular response to hyperoxia;GO:0090575,cellular_component RNA polymerase II transcription factor complex;GO:1901558,biological_process response to metformin;GO:2000230,biological_process negative regulation of pancreatic stellate cell proliferation	NR1C3, PPARG; peroxisome proliferator-activated receptor gamma; K08530	peroxisome proliferator activated receptor gamma [Source:HGNC Symbol%3BAcc:HGNC:9236]
ENSG00000162572	7.07	6.23	7.55	7.23	6.44	7.64	-0.0132308224748658	4.14443585023093	0.887780339147198	0.981738739406163	1:1280435-1292029:+	SCNN1D	14;GO:0005272,molecular_function sodium channel activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0015280,molecular_function ligand-gated sodium channel activity;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034220,biological_process ion transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0050896,biological_process response to stimulus;GO:0050909,biological_process sensory perception of taste	NA	sodium channel epithelial 1 delta subunit [Source:HGNC Symbol%3BAcc:HGNC:10601]
ENSG00000156508	8152.96	7859.82	8152.89	8385.71	7634.77	8200.71	0.00844951579125808	13.4534306117675	0.887874608365262	0.981755524108142	6:73515749-73523797:-	EEF1A1	32;GO:0000049,molecular_function tRNA binding;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005853,cellular_component eukaryotic translation elongation factor 1 complex;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0006479,biological_process protein methylation;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0032587,cellular_component ruffle membrane;GO:0034774,cellular_component secretory granule lumen;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0098574,cellular_component cytoplasmic side of lysosomal membrane;GO:1904714,biological_process regulation of chaperone-mediated autophagy;GO:1904813,cellular_component ficolin-1-rich granule lumen	EEF1A; elongation factor 1-alpha; K03231	eukaryotic translation elongation factor 1 alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:3189]
ENSG00000178852	8.01	8.46	9.13	8.96	8.86	8.24	-0.0132353816251994	4.66439724388647	0.888124066160386	0.981943888238075	17:47323289-47441312:+	EFCAB13	NA	NA	EF-hand calcium binding domain 13 [Source:HGNC Symbol%3BAcc:HGNC:26864]
ENSG00000165801	17.35	17.77	18.49	16.51	19.22	18.72	-0.0106545189448116	6.39374956297465	0.888346862837943	0.981996691074834	14:21070269-21090240:+	ARHGEF40	5;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005737,cellular_component cytoplasm;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	Rho guanine nucleotide exchange factor 40 [Source:HGNC Symbol%3BAcc:HGNC:25516]
ENSG00000130332	122.44	124.62	112.99	121.53	122.34	116.25	0.0097543599675119	5.58255849975539	0.88860944525842	0.981996691074834	19:2321516-2328620:-	LSM7	20;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005688,cellular_component U6 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0017070,molecular_function U6 snRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0071004,cellular_component U2-type prespliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:0097526,cellular_component spliceosomal tri-snRNP complex;GO:1990726,cellular_component Lsm1-7-Pat1 complex	NA	LSM7 homolog%2C U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol%3BAcc:HGNC:20470]
ENSG00000197568	33.57	34.70	40.02	39.43	31.00	37.43	0.018111156208476	4.25775156946799	0.888686229840273	0.981996691074834	1:70354804-70385339:+	HHLA3	1;GO:0005515,molecular_function protein binding	NA	HERV-H LTR-associating 3 [Source:HGNC Symbol%3BAcc:HGNC:4906]
ENSG00000151748	9.38	7.80	8.86	8.96	9.31	8.41	-0.0122764161186656	3.52382063016572	0.888940038312792	0.981996691074834	14:50632057-50668331:-	SAV1	23;GO:0001942,biological_process hair follicle development;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0030216,biological_process keratinocyte differentiation;GO:0032947,molecular_function protein complex scaffold;GO:0035329,biological_process hippo signaling;GO:0042127,biological_process regulation of cell proliferation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0046620,biological_process regulation of organ growth;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050821,biological_process protein stabilization;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0060044,biological_process negative regulation of cardiac muscle cell proliferation;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060487,biological_process lung epithelial cell differentiation;GO:0060575,biological_process intestinal epithelial cell differentiation;GO:2000036,biological_process regulation of stem cell population maintenance	SAV1, Sav; scaffold protein salvador; K16686	salvador family WW domain containing protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17795]
ENSG00000010318	7.04	6.61	7.15	7.47	7.03	6.15	0.0285909957647358	3.01014451620684	0.888958040247212	0.981996691074834	3:52410656-52423641:+	PHF7	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016607,cellular_component nuclear speck;GO:0046872,molecular_function metal ion binding	NA	PHD finger protein 7 [Source:HGNC Symbol%3BAcc:HGNC:18458]
ENSG00000198466	7.37	8.25	8.53	8.98	7.34	8.28	-0.0180672476709322	3.82458915871785	0.889049379283823	0.981996691074834	19:57849856-57865112:+	ZNF587	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 587 [Source:HGNC Symbol%3BAcc:HGNC:30955]
ENSG00000133027	18.67	19.64	20.29	21.67	18.82	19.30	-0.0179132086254623	3.99117514319275	0.889093828099932	0.981996691074834	17:17505562-17591708:-	PEMT	34;GO:0000773,molecular_function phosphatidyl-N-methylethanolamine N-methyltransferase activity;GO:0004608,molecular_function phosphatidylethanolamine N-methyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006686,biological_process sphingomyelin biosynthetic process;GO:0007584,biological_process response to nutrient;GO:0008168,molecular_function methyltransferase activity;GO:0008170,molecular_function N-methyltransferase activity;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008429,molecular_function phosphatidylethanolamine binding;GO:0008654,biological_process phospholipid biosynthetic process;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0031526,cellular_component brush border membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032259,biological_process methylation;GO:0033273,biological_process response to vitamin;GO:0042383,cellular_component sarcolemma;GO:0042493,biological_process response to drug;GO:0043200,biological_process response to amino acid;GO:0045471,biological_process response to ethanol;GO:0046498,biological_process S-adenosylhomocysteine metabolic process;GO:0046500,biological_process S-adenosylmethionine metabolic process;GO:0050747,biological_process positive regulation of lipoprotein metabolic process;GO:0080101,molecular_function phosphatidyl-N-dimethylethanolamine N-methyltransferase activity;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	PEMT; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71]; K00551	phosphatidylethanolamine N-methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:8830]
ENSG00000058799	30.08	26.55	29.99	28.63	25.94	33.78	-0.0142755537174184	4.75525624359521	0.889105623118735	0.981996691074834	1:53851718-53889834:-	YIPF1	6;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0030133,cellular_component transport vesicle	NA	Yip1 domain family member 1 [Source:HGNC Symbol%3BAcc:HGNC:25231]
ENSG00000115548	18.79	18.37	18.94	17.03	20.70	19.26	-0.0106058734580294	6.24991632195978	0.889175385940533	0.981996691074834	2:86440646-86492716:+	KDM3A	35;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005506,molecular_function iron ion binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007283,biological_process spermatogenesis;GO:0007290,biological_process spermatid nucleus elongation;GO:0009755,biological_process hormone-mediated signaling pathway;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0030154,biological_process cell differentiation;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031490,molecular_function chromatin DNA binding;GO:0032452,molecular_function histone demethylase activity;GO:0032454,molecular_function histone demethylase activity (H3-K9 specific);GO:0033169,biological_process histone H3-K9 demethylation;GO:0036123,biological_process histone H3-K9 dimethylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046293,biological_process formaldehyde biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0051213,molecular_function dioxygenase activity;GO:0051573,biological_process negative regulation of histone H3-K9 methylation;GO:0055114,biological_process oxidation-reduction process;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000036,biological_process regulation of stem cell population maintenance;GO:2000736,biological_process regulation of stem cell differentiation	KDM3; [histone H3]-dimethyl-L-lysine9 demethylase [EC:1.14.11.65]; K15601	lysine demethylase 3A [Source:HGNC Symbol%3BAcc:HGNC:20815]
ENSG00000173409	25.09	24.31	24.61	24.05	24.37	25.52	0.0137998666335034	4.50241174452691	0.889230836756161	0.981996691074834	1:230978980-231000595:+	ARV1	19;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008206,biological_process bile acid metabolic process;GO:0015248,molecular_function sterol transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030301,biological_process cholesterol transport;GO:0032383,biological_process regulation of intracellular cholesterol transport;GO:0032541,cellular_component cortical endoplasmic reticulum;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:0097036,biological_process regulation of plasma membrane sterol distribution	NA	ARV1 homolog%2C fatty acid homeostasis modulator [Source:HGNC Symbol%3BAcc:HGNC:29561]
ENSG00000105227	2.92	2.86	2.60	3.07	2.36	3.15	-0.0230799953534951	3.66956764571492	0.889418830292916	0.981996691074834	19:40393767-40413366:-	PRX	8;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0008366,biological_process axon ensheathment;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction	NA	periaxin [Source:HGNC Symbol%3BAcc:HGNC:13797]
ENSG00000179021	20.25	18.11	18.94	20.79	19.06	17.45	0.017458981435458	4.250289233192	0.889438140063222	0.981996691074834	3:88149742-88168729:+	C3orf38	4;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0006915,biological_process apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process	NA	chromosome 3 open reading frame 38 [Source:HGNC Symbol%3BAcc:HGNC:28384]
ENSG00000162073	9.66	9.22	10.42	9.51	9.54	10.99	-0.0213996180675613	3.04920301584746	0.889455542141906	0.981996691074834	16:2969244-2973489:+	PAQR4	3;GO:0004872,molecular_function receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	progestin and adipoQ receptor family member 4 [Source:HGNC Symbol%3BAcc:HGNC:26386]
ENSG00000103202	4.45	4.09	5.55	4.22	5.55	4.83	-0.0272834312456579	2.14352709622531	0.889493700259556	0.981996691074834	16:396724-410367:+	NME4	26;GO:0000166,molecular_function nucleotide binding;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006183,biological_process GTP biosynthetic process;GO:0006228,biological_process UTP biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0009116,biological_process nucleoside metabolic process;GO:0009117,biological_process nucleotide metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:1901612,molecular_function cardiolipin binding	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]; K00940	NME/NM23 nucleoside diphosphate kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:7852]
ENSG00000117500	82.57	87.43	89.36	80.06	88.67	90.85	0.00953450518621415	6.15541589499189	0.889668465226559	0.981996691074834	1:93149741-93180728:-	TMED5	13;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070971,cellular_component endoplasmic reticulum exit site;GO:0090161,biological_process Golgi ribbon formation	NA	transmembrane p24 trafficking protein 5 [Source:HGNC Symbol%3BAcc:HGNC:24251]
ENSG00000198952	43.38	41.70	45.20	43.41	43.67	43.51	0.00942428591925603	7.05302264464403	0.889762564808499	0.981996691074834	1:156249223-156282825:-	SMG5	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0004540,molecular_function ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006406,biological_process mRNA export from nucleus;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032204,biological_process regulation of telomere maintenance;GO:0032210,biological_process regulation of telomere maintenance via telomerase;GO:0035303,biological_process regulation of dephosphorylation;GO:0042162,molecular_function telomeric DNA binding;GO:0042826,molecular_function histone deacetylase binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0043487,biological_process regulation of RNA stability;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0070034,molecular_function telomerase RNA binding;GO:0070182,molecular_function DNA polymerase binding;GO:0090501,biological_process RNA phosphodiester bond hydrolysis	SMG5, EST1B; protein SMG5; K11125	SMG5%2C nonsense mediated mRNA decay factor [Source:HGNC Symbol%3BAcc:HGNC:24644]
ENSG00000148200	2.86	2.56	3.08	2.67	3.44	2.27	0.0455649303217629	2.08956090561046	0.889822420810082	0.981996691074834	9:124517274-124771310:-	NR6A1	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007276,biological_process gamete generation;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	nuclear receptor subfamily 6 group A member 1 [Source:HGNC Symbol%3BAcc:HGNC:7985]
ENSG00000176171	170.26	187.34	187.29	184.86	183.96	183.91	-0.00971327073275922	7.20613660541302	0.889883602312404	0.981996691074834	10:131966454-131982013:-	BNIP3	65;GO:0000422,biological_process mitophagy;GO:0001666,biological_process response to hypoxia;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0006915,biological_process apoptotic process;GO:0008219,biological_process cell death;GO:0008626,biological_process granzyme-mediated apoptotic signaling pathway;GO:0010508,biological_process positive regulation of autophagy;GO:0010637,biological_process negative regulation of mitochondrial fusion;GO:0010659,biological_process cardiac muscle cell apoptotic process;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0010821,biological_process regulation of mitochondrion organization;GO:0010917,biological_process negative regulation of mitochondrial membrane potential;GO:0010940,biological_process positive regulation of necrotic cell death;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016239,biological_process positive regulation of macroautophagy;GO:0021987,biological_process cerebral cortex development;GO:0030425,cellular_component dendrite;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0035694,biological_process mitochondrial protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043068,biological_process positive regulation of programmed cell death;GO:0043243,biological_process positive regulation of protein complex disassembly;GO:0043653,biological_process mitochondrial fragmentation involved in apoptotic process;GO:0045837,biological_process negative regulation of membrane potential;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0046982,molecular_function protein heterodimerization activity;GO:0048102,biological_process autophagic cell death;GO:0048709,biological_process oligodendrocyte differentiation;GO:0050873,biological_process brown fat cell differentiation;GO:0051020,molecular_function GTPase binding;GO:0051402,biological_process neuron apoptotic process;GO:0051561,biological_process positive regulation of mitochondrial calcium ion concentration;GO:0051607,biological_process defense response to virus;GO:0055093,biological_process response to hyperoxia;GO:0060548,biological_process negative regulation of cell death;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071279,biological_process cellular response to cobalt ion;GO:0071456,biological_process cellular response to hypoxia;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:0097345,biological_process mitochondrial outer membrane permeabilization;GO:1901998,biological_process toxin transport;GO:1902109,biological_process negative regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1903599,biological_process positive regulation of mitophagy;GO:1903715,biological_process regulation of aerobic respiration;GO:1990144,biological_process intrinsic apoptotic signaling pathway in response to hypoxia;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; K15464	BCL2 interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:1084]
ENSG00000221838	13.38	12.40	12.93	13.20	11.98	14.24	-0.0130666137823098	4.32653134630822	0.89000028163085	0.981996691074834	7:100101548-100110345:+	AP4M1	17;GO:0000138,cellular_component Golgi trans cisterna;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006895,biological_process Golgi to endosome transport;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0030131,cellular_component clathrin adaptor complex;GO:0031904,cellular_component endosome lumen;GO:0032588,cellular_component trans-Golgi network membrane;GO:0070062,cellular_component extracellular exosome	AP4M1; AP-4 complex subunit mu-1; K12402	adaptor related protein complex 4 mu 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:574]
ENSG00000125744	10.45	9.50	9.33	8.99	9.98	10.23	0.0177361397119055	4.02264629323667	0.890035045903814	0.981996691074834	19:45485288-45497061:-	RTN2	10;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0014802,cellular_component terminal cisterna;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030315,cellular_component T-tubule;GO:0046324,biological_process regulation of glucose import;GO:0065002,biological_process intracellular protein transmembrane transport	NA	reticulon 2 [Source:HGNC Symbol%3BAcc:HGNC:10468]
ENSG00000014123	22.74	22.59	23.70	23.92	22.73	22.49	0.0103247755449752	5.78268476321491	0.890082796705612	0.981996691074834	6:96521594-96555276:+	UFL1	24;GO:0001649,biological_process osteoblast differentiation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032434,biological_process regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032880,biological_process regulation of protein localization;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043005,cellular_component neuron projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0060252,biological_process positive regulation of glial cell proliferation;GO:0071568,molecular_function UFM1 transferase activity;GO:0071569,biological_process protein ufmylation;GO:1902065,biological_process response to L-glutamate;GO:1990592,biological_process protein K69-linked ufmylation	NA	UFM1 specific ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:23039]
ENSG00000143727	117.44	122.87	121.86	129.31	118.31	119.84	-0.00998061312981002	6.41471826997866	0.890154542393757	0.981996691074834	2:264139-278283:+	ACP1	16;GO:0003993,molecular_function acid phosphatase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042383,cellular_component sarcolemma;GO:0070062,cellular_component extracellular exosome	ACP1; low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.2 3.1.3.48]; K14394	acid phosphatase 1%2C soluble [Source:HGNC Symbol%3BAcc:HGNC:122]
ENSG00000151552	37.67	33.68	35.55	33.00	39.73	34.15	0.0164366480822077	4.72135053428147	0.890204768971232	0.981996691074834	4:17460260-17512234:-	QDPR	21;GO:0001889,biological_process liver development;GO:0004155,molecular_function 6,7-dihydropteridine reductase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006559,biological_process L-phenylalanine catabolic process;GO:0006729,biological_process tetrahydrobiopterin biosynthetic process;GO:0009055,molecular_function electron carrier activity;GO:0010044,biological_process response to aluminum ion;GO:0010288,biological_process response to lead ion;GO:0016491,molecular_function oxidoreductase activity;GO:0033762,biological_process response to glucagon;GO:0035690,biological_process cellular response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0051066,biological_process dihydrobiopterin metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070402,molecular_function NADPH binding;GO:0070404,molecular_function NADH binding	QDPR; dihydropteridine reductase [EC:1.5.1.34]; K00357	quinoid dihydropteridine reductase [Source:HGNC Symbol%3BAcc:HGNC:9752]
ENSG00000149930	16.07	15.67	16.19	15.66	16.11	16.26	0.00931616140481025	6.25325565680299	0.890270600395922	0.981996691074834	16:29973640-29992261:+	TAOK2	39;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001558,biological_process regulation of cell growth;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006612,biological_process protein targeting to membrane;GO:0006915,biological_process apoptotic process;GO:0006950,biological_process response to stress;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0007399,biological_process nervous system development;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0030425,cellular_component dendrite;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0043235,cellular_component receptor complex;GO:0046330,biological_process positive regulation of JNK cascade;GO:0048041,biological_process focal adhesion assembly;GO:0051403,biological_process stress-activated MAPK cascade	TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]; K04429	TAO kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:16835]
ENSG00000163681	19.14	17.97	18.17	19.10	17.95	19.08	-0.009275596232984	5.69118586211399	0.89044261529424	0.981996691074834	3:57755449-57929168:+	SLMAP	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006936,biological_process muscle contraction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042383,cellular_component sarcolemma;GO:0072659,biological_process protein localization to plasma membrane;GO:1900825,biological_process regulation of membrane depolarization during cardiac muscle cell action potential;GO:1902305,biological_process regulation of sodium ion transmembrane transport;GO:1905150,biological_process regulation of voltage-gated sodium channel activity	NA	sarcolemma associated protein [Source:HGNC Symbol%3BAcc:HGNC:16643]
ENSG00000106608	17.26	17.53	16.77	17.88	16.65	17.06	0.00934404816789575	5.64735341761576	0.890449575579638	0.981996691074834	7:43875893-43926411:-	URGCP	5;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle	NA	upregulator of cell proliferation [Source:HGNC Symbol%3BAcc:HGNC:30890]
ENSG00000111481	110.19	113.37	106.18	108.32	111.75	110.11	0.00844668519600408	6.29832624413642	0.890499139492984	0.981996691074834	12:54301201-54351849:+	COPZ1	19;GO:0000139,cellular_component Golgi membrane;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030117,cellular_component membrane coat;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:1901998,biological_process toxin transport	NA	coatomer protein complex subunit zeta 1 [Source:HGNC Symbol%3BAcc:HGNC:2243]
ENSG00000136147	10.16	9.65	10.37	10.27	8.52	11.18	0.0220003278687002	3.42047399810305	0.890521484555026	0.981996691074834	13:49495609-49528987:+	PHF11	6;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031965,cellular_component nuclear membrane;GO:0046872,molecular_function metal ion binding	NA	PHD finger protein 11 [Source:HGNC Symbol%3BAcc:HGNC:17024]
ENSG00000168887	24.13	21.10	24.33	23.50	22.86	23.24	0.0188568389131025	4.07904250948097	0.890526069931168	0.981996691074834	2:85606653-85612066:-	C2orf68	NA	NA	chromosome 2 open reading frame 68 [Source:HGNC Symbol%3BAcc:HGNC:34353]
ENSG00000163975	35.21	31.21	32.93	36.81	28.80	35.46	-0.0118851482400662	6.36833514524926	0.890653489248745	0.981996691074834	3:196988620-197029816:-	MELTF	23;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0009986,cellular_component cell surface;GO:0010756,biological_process positive regulation of plasminogen activation;GO:0016020,cellular_component membrane;GO:0031225,cellular_component anchored component of membrane;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0046658,cellular_component anchored component of plasma membrane;GO:0046872,molecular_function metal ion binding;GO:0055072,biological_process iron ion homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0090091,biological_process positive regulation of extracellular matrix disassembly;GO:0097286,biological_process iron ion import;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading	NA	melanotransferrin [Source:HGNC Symbol%3BAcc:HGNC:7037]
ENSG00000177963	36.52	44.52	39.53	40.10	39.18	41.22	0.00892720573079454	6.32594083251524	0.890726473782214	0.981996691074834	11:207510-215113:+	RIC8A	18;GO:0001701,biological_process in utero embryonic development;GO:0001944,biological_process vasculature development;GO:0001965,molecular_function G-protein alpha-subunit binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007193,biological_process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007369,biological_process gastrulation;GO:0008542,biological_process visual learning;GO:0009416,biological_process response to light stimulus;GO:0016020,cellular_component membrane;GO:0042074,biological_process cell migration involved in gastrulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0070586,biological_process cell-cell adhesion involved in gastrulation;GO:0071711,biological_process basement membrane organization	NA	RIC8 guanine nucleotide exchange factor A [Source:HGNC Symbol%3BAcc:HGNC:29550]
ENSG00000184863	14.05	13.66	15.17	14.97	14.36	14.24	-0.00890201531290917	5.80355355217331	0.89076606344046	0.981996691074834	7:155644450-155781485:+	RBM33	2;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding	NA	RNA binding motif protein 33 [Source:HGNC Symbol%3BAcc:HGNC:27223]
ENSG00000163806	1.95	2.54	2.42	1.75	2.74	2.16	0.0555030525308164	1.18176481740007	0.890782465278549	0.981996691074834	2:28782516-28850611:+	SPDYA	10;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007140,biological_process male meiosis;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0019901,molecular_function protein kinase binding;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDY, RINGO; speedy; K08694	speedy/RINGO cell cycle regulator family member A [Source:HGNC Symbol%3BAcc:HGNC:30613]
ENSG00000130779	18.55	16.83	19.89	18.82	17.86	19.50	-0.00926243882132139	6.37306281583415	0.890896526273621	0.982035217177379	12:122271431-122422632:-	CLIP1	32;GO:0000278,biological_process mitotic cell cycle;GO:0000776,cellular_component kinetochore;GO:0001578,biological_process microtubule bundle formation;GO:0001726,cellular_component ruffle;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005882,cellular_component intermediate filament;GO:0006810,biological_process transport;GO:0007062,biological_process sister chromatid cohesion;GO:0008017,molecular_function microtubule binding;GO:0008270,molecular_function zinc ion binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0035371,cellular_component microtubule plus-end;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0044354,cellular_component macropinosome;GO:0044861,biological_process protein transport into plasma membrane raft;GO:0046872,molecular_function metal ion binding;GO:0051010,molecular_function microtubule plus-end binding	CLIP1, RSN; CAP-Gly domain-containing linker protein 1; K10421	CAP-Gly domain containing linker protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10461]
ENSG00000169641	14.94	13.33	12.63	14.05	12.71	14.83	-0.0118642996612581	5.48149819573054	0.89100086374697	0.982063019152117	1:23084022-23177808:-	LUZP1	6;GO:0003281,biological_process ventricular septum development;GO:0005634,cellular_component nucleus;GO:0016020,cellular_component membrane;GO:0021503,biological_process neural fold bending;GO:0060840,biological_process artery development;GO:0070062,cellular_component extracellular exosome	NA	leucine zipper protein 1 [Source:HGNC Symbol%3BAcc:HGNC:14985]
ENSG00000188554	37.49	35.80	36.55	35.38	37.36	37.35	0.00922127010331945	6.77543907523724	0.891260610834238	0.982199724366835	17:43170480-43211689:+	NBR1	24;GO:0000407,cellular_component pre-autophagosomal structure;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005764,cellular_component lysosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0016604,cellular_component nuclear body;GO:0030500,biological_process regulation of bone mineralization;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031430,cellular_component M band;GO:0032872,biological_process regulation of stress-activated MAPK cascade;GO:0043130,molecular_function ubiquitin binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0046872,molecular_function metal ion binding;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome	NA	NBR1%2C autophagy cargo receptor [Source:HGNC Symbol%3BAcc:HGNC:6746]
ENSG00000221944	4.42	4.47	4.69	4.48	5.00	4.01	0.0257281978487799	3.02655420856662	0.891305966996774	0.982199724366835	2:232547967-232550592:-	TIGD1	3;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus	NA	tigger transposable element derived 1 [Source:HGNC Symbol%3BAcc:HGNC:14523]
ENSG00000028528	43.99	43.95	41.48	42.72	44.73	42.18	0.00900835776155222	6.33996062807276	0.891437899829117	0.982199724366835	15:64094122-64146090:+	SNX1	39;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008289,molecular_function lipid binding;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0016197,biological_process endosomal transport;GO:0019898,cellular_component extrinsic component of membrane;GO:0030027,cellular_component lamellipodium;GO:0030904,cellular_component retromer complex;GO:0030905,cellular_component retromer, tubulation complex;GO:0031623,biological_process receptor internalization;GO:0031901,cellular_component early endosome membrane;GO:0031982,cellular_component vesicle;GO:0034498,biological_process early endosome to Golgi transport;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045296,molecular_function cadherin binding;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046982,molecular_function protein heterodimerization activity;GO:0072673,biological_process lamellipodium morphogenesis;GO:1990459,molecular_function transferrin receptor binding;GO:1990460,molecular_function leptin receptor binding	NA	sorting nexin 1 [Source:HGNC Symbol%3BAcc:HGNC:11172]
ENSG00000269343	3.63	3.47	3.15	3.44	2.91	4.15	-0.0251382076185621	2.81266054512315	0.891441399719388	0.982199724366835	19:57819740-57846238:+	ZNF587B	6;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 587B [Source:HGNC Symbol%3BAcc:HGNC:37142]
ENSG00000054118	61.04	71.52	60.58	61.88	70.55	60.67	0.0108217932772373	7.52810880543027	0.891619231844026	0.982287460936935	1:36224415-36305357:+	THRAP3	35;GO:0000166,molecular_function nucleotide binding;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0007623,biological_process circadian rhythm;GO:0008380,biological_process RNA splicing;GO:0016592,cellular_component mediator complex;GO:0016607,cellular_component nuclear speck;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0035145,cellular_component exon-exon junction complex;GO:0042753,biological_process positive regulation of circadian rhythm;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046966,molecular_function thyroid hormone receptor binding;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0048255,biological_process mRNA stabilization;GO:0048511,biological_process rhythmic process;GO:0051219,molecular_function phosphoprotein binding;GO:0070062,cellular_component extracellular exosome	NA	thyroid hormone receptor associated protein 3 [Source:HGNC Symbol%3BAcc:HGNC:22964]
ENSG00000135637	3.70	3.23	3.73	3.29	3.94	3.38	0.0282517423452234	3.02733635177014	0.891720208457458	0.982287460936935	2:74471985-74483408:-	CCDC142	NA	NA	coiled-coil domain containing 142 [Source:HGNC Symbol%3BAcc:HGNC:25889]
ENSG00000075131	10.33	10.02	11.97	10.14	12.42	9.60	0.0259595358758966	3.32292803080116	0.891758430459866	0.982287460936935	15:66336205-66386746:-	TIPIN	21;GO:0000076,biological_process DNA replication checkpoint;GO:0000077,biological_process DNA damage checkpoint;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009411,biological_process response to UV;GO:0031298,cellular_component replication fork protection complex;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0033262,biological_process regulation of nuclear cell cycle DNA replication;GO:0043111,biological_process replication fork arrest;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0044770,biological_process cell cycle phase transition;GO:0048478,biological_process replication fork protection;GO:0051301,biological_process cell division	NA	TIMELESS interacting protein [Source:HGNC Symbol%3BAcc:HGNC:30750]
ENSG00000178966	12.28	12.28	12.99	13.26	12.09	12.86	-0.0126062128157924	4.57631192848317	0.891888334750989	0.982302580423623	9:83980710-84004074:+	RMI1	9;GO:0000166,molecular_function nucleotide binding;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0016604,cellular_component nuclear body;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RMI1, BRAP75; RecQ-mediated genome instability protein 1; K10990	RecQ mediated genome instability 1 [Source:HGNC Symbol%3BAcc:HGNC:25764]
ENSG00000005194	29.88	31.75	32.00	31.44	31.28	30.88	0.0106606575148116	4.87577120509572	0.892027839454524	0.982302580423623	16:57428168-57447528:-	CIAPIN1	17;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006915,biological_process apoptotic process;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016226,biological_process iron-sulfur cluster assembly;GO:0030097,biological_process hemopoiesis;GO:0032259,biological_process methylation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding	NA	cytokine induced apoptosis inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:28050]
ENSG00000012211	4.62	4.79	4.52	4.63	4.38	4.82	0.0168979795625319	3.20137605767148	0.892156001995567	0.982302580423623	X:49175263-49186528:-	PRICKLE3	5;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0008270,molecular_function zinc ion binding;GO:0046872,molecular_function metal ion binding	NA	prickle planar cell polarity protein 3 [Source:HGNC Symbol%3BAcc:HGNC:6645]
ENSG00000113384	118.53	113.31	117.85	117.68	117.68	119.42	-0.00821714634395016	6.80166152539753	0.892227731940391	0.982302580423623	5:32124703-32174350:-	GOLPH3	36;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007030,biological_process Golgi organization;GO:0008283,biological_process cell proliferation;GO:0008289,molecular_function lipid binding;GO:0009101,biological_process glycoprotein biosynthetic process;GO:0009306,biological_process protein secretion;GO:0010467,biological_process gene expression;GO:0010821,biological_process regulation of mitochondrion organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0019899,molecular_function enzyme binding;GO:0030032,biological_process lamellipodium assembly;GO:0031985,cellular_component Golgi cisterna;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032580,cellular_component Golgi cisterna membrane;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045053,biological_process protein retention in Golgi apparatus;GO:0048194,biological_process Golgi vesicle budding;GO:0050714,biological_process positive regulation of protein secretion;GO:0050901,biological_process leukocyte tethering or rolling;GO:0060352,biological_process cell adhesion molecule production;GO:0070273,molecular_function phosphatidylinositol-4-phosphate binding;GO:0090161,biological_process Golgi ribbon formation;GO:0090164,biological_process asymmetric Golgi ribbon formation	NA	golgi phosphoprotein 3 [Source:HGNC Symbol%3BAcc:HGNC:15452]
ENSG00000204084	15.20	14.50	16.14	16.99	14.67	14.96	-0.0100007884768449	5.61397582436876	0.892245884337657	0.982302580423623	1:37860696-37947057:-	INPP5B	27;GO:0001701,biological_process in utero embryonic development;GO:0004439,molecular_function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030317,biological_process sperm motility;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0052658,molecular_function inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0070613,biological_process regulation of protein processing	INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]; K01099	inositol polyphosphate-5-phosphatase B [Source:HGNC Symbol%3BAcc:HGNC:6077]
ENSG00000165458	44.82	42.00	47.81	43.61	46.91	44.38	0.00995587511325966	7.44098982149899	0.892287993071575	0.982302580423623	11:72223700-72239105:+	INPPL1	31;GO:0001958,biological_process endochondral ossification;GO:0002376,biological_process immune system process;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006006,biological_process glucose metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006897,biological_process endocytosis;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009791,biological_process post-embryonic development;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0017124,molecular_function SH3 domain binding;GO:0030027,cellular_component lamellipodium;GO:0030175,cellular_component filopodium;GO:0032868,biological_process response to insulin;GO:0034485,molecular_function phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0042169,molecular_function SH2 domain binding;GO:0042995,cellular_component cell projection;GO:0043647,biological_process inositol phosphate metabolic process;GO:0044255,biological_process cellular lipid metabolic process;GO:0046856,biological_process phosphatidylinositol dephosphorylation;GO:0052659,molecular_function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0097178,biological_process ruffle assembly	SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]; K15909	inositol polyphosphate phosphatase like 1 [Source:HGNC Symbol%3BAcc:HGNC:6080]
ENSG00000004139	3.46	3.49	4.06	3.96	3.54	3.78	-0.0225367870382974	3.09114828754354	0.892387712496639	0.982302580423623	17:28364355-28404049:+	SARM1	22;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0009749,biological_process response to glucose;GO:0015630,cellular_component microtubule cytoskeleton;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031315,cellular_component extrinsic component of mitochondrial outer membrane;GO:0034128,biological_process negative regulation of MyD88-independent toll-like receptor signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0045087,biological_process innate immune response;GO:0045202,cellular_component synapse;GO:0048814,biological_process regulation of dendrite morphogenesis;GO:1901214,biological_process regulation of neuron death	NA	sterile alpha and TIR motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17074]
ENSG00000169976	248.01	268.18	237.35	241.16	285.14	239.03	-0.0123982196871452	6.03204890851367	0.892405236400322	0.982302580423623	6:144094880-144095573:-	SF3B5	9;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005686,cellular_component U2 snRNP;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0071011,cellular_component precatalytic spliceosome	NA	splicing factor 3b subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:21083]
ENSG00000119596	17.79	19.77	17.70	17.75	19.85	17.69	0.00940437930736811	6.93259267162756	0.892950274185198	0.982752702750824	14:74763365-74859435:+	YLPM1	9;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0016607,cellular_component nuclear speck	NA	YLP motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17798]
ENSG00000268861	1.45	1.62	1.25	1.54	1.33	1.55	-0.0340776599212024	2.33098090160106	0.892972507397611	0.982752702750824	19:7382833-7472477:+	AC008878.3	6;GO:0003676,molecular_function nucleic acid binding;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	NA
ENSG00000108395	28.04	25.81	26.01	27.08	25.23	28.77	-0.0094652298734554	6.3504965233366	0.893150928222652	0.982861921279058	17:58982637-59106921:-	TRIM37	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003682,molecular_function chromatin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016235,cellular_component aggresome;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0035098,cellular_component ESC/E(Z) complex;GO:0035518,biological_process histone H2A monoubiquitination;GO:0036353,biological_process histone H2A-K119 monoubiquitination;GO:0042803,molecular_function protein homodimerization activity;GO:0046600,biological_process negative regulation of centriole replication;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070842,biological_process aggresome assembly	TRIM37, MUL; tripartite motif-containing protein 37 [EC:2.3.2.27]; K10608	tripartite motif containing 37 [Source:HGNC Symbol%3BAcc:HGNC:7523]
ENSG00000171169	4.25	5.26	5.40	4.50	5.41	4.80	0.0236089687668812	2.31659754782113	0.893478379587365	0.983063387860846	9:128061232-128068206:-	NAIF1	9;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0030308,biological_process negative regulation of cell growth;GO:1902108,biological_process regulation of mitochondrial membrane permeability involved in apoptotic process	NA	nuclear apoptosis inducing factor 1 [Source:HGNC Symbol%3BAcc:HGNC:25446]
ENSG00000169062	18.73	21.80	22.20	21.95	20.96	20.81	-0.0145010385060967	4.919118632959	0.893492398440834	0.983063387860846	13:114281583-114305817:+	UPF3A	16;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0035145,cellular_component exon-exon junction complex;GO:0042162,molecular_function telomeric DNA binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045727,biological_process positive regulation of translation;GO:0051028,biological_process mRNA transport	UPF3, RENT3; regulator of nonsense transcripts 3; K14328	UPF3A%2C regulator of nonsense mediated mRNA decay [Source:HGNC Symbol%3BAcc:HGNC:20332]
ENSG00000135974	21.51	21.28	23.69	25.06	20.70	22.13	-0.0159928000027173	3.97858090126638	0.893649079524931	0.983148632823094	2:105337358-105349211:+	C2orf49	6;GO:0003674,molecular_function molecular_function;GO:0005654,cellular_component nucleoplasm;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0008150,biological_process biological_process;GO:0048598,biological_process embryonic morphogenesis;GO:0072669,cellular_component tRNA-splicing ligase complex	NA	chromosome 2 open reading frame 49 [Source:HGNC Symbol%3BAcc:HGNC:28772]
ENSG00000251247	2.37	2.29	2.55	2.06	3.22	2.19	-0.0329661806359472	2.08535045702862	0.89383308427246	0.983191228750375	19:36850360-36913029:+	ZNF345	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 345 [Source:HGNC Symbol%3BAcc:HGNC:16367]
ENSG00000082512	2.41	1.54	2.11	2.73	1.63	1.60	0.0550301689559773	1.82018120297152	0.893846210944009	0.983191228750375	1:211326614-211374946:+	TRAF5	17;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031996,molecular_function thioesterase binding;GO:0035631,cellular_component CD40 receptor complex;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity	TRAF5; TNF receptor-associated factor 5; K09849	TNF receptor associated factor 5 [Source:HGNC Symbol%3BAcc:HGNC:12035]
ENSG00000256683	6.77	6.71	6.32	5.54	6.51	7.58	0.0206993608639585	3.41262783679706	0.894065005676281	0.983217827228559	19:51964342-51986856:-	ZNF350	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001162,molecular_function RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016363,cellular_component nuclear matrix;GO:0016604,cellular_component nuclear body;GO:0017053,cellular_component transcriptional repressor complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 350 [Source:HGNC Symbol%3BAcc:HGNC:16656]
ENSG00000167325	39.94	46.14	36.74	42.07	41.92	38.76	0.0101568851687179	6.67948723893807	0.894111412467011	0.983217827228559	11:4094706-4138876:+	RRM1	16;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004748,molecular_function ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0008152,biological_process metabolic process;GO:0009263,biological_process deoxyribonucleotide biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome	RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]; K10807	ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol%3BAcc:HGNC:10451]
ENSG00000143507	18.56	16.19	19.90	20.66	16.68	18.43	-0.0119361059565264	4.74664431343028	0.894127824081265	0.983217827228559	1:221701423-221742176:-	DUSP10	40;GO:0000188,biological_process inactivation of MAPK activity;GO:0002819,biological_process regulation of adaptive immune response;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0008432,molecular_function JUN kinase binding;GO:0010033,biological_process response to organic substance;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0016311,biological_process dephosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0030336,biological_process negative regulation of cell migration;GO:0032496,biological_process response to lipopolysaccharide;GO:0032873,biological_process negative regulation of stress-activated MAPK cascade;GO:0033549,molecular_function MAP kinase phosphatase activity;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0043508,biological_process negative regulation of JUN kinase activity;GO:0044387,biological_process negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045088,biological_process regulation of innate immune response;GO:0045591,biological_process positive regulation of regulatory T cell differentiation;GO:0046329,biological_process negative regulation of JNK cascade;GO:0048273,molecular_function mitogen-activated protein kinase p38 binding;GO:0048709,biological_process oligodendrocyte differentiation;GO:0048715,biological_process negative regulation of oligodendrocyte differentiation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0060266,biological_process negative regulation of respiratory burst involved in inflammatory response;GO:0070303,biological_process negative regulation of stress-activated protein kinase signaling cascade;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0090335,biological_process regulation of brown fat cell differentiation;GO:1903753,biological_process negative regulation of p38MAPK cascade;GO:1905042,biological_process negative regulation of epithelium regeneration;GO:1990264,biological_process peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 10 [Source:HGNC Symbol%3BAcc:HGNC:3065]
ENSG00000071539	26.66	32.25	24.46	26.46	28.74	29.46	-0.0171967166491254	5.26974613365347	0.89426232068427	0.983217827228559	5:892642-919357:+	TRIP13	20;GO:0000166,molecular_function nucleotide binding;GO:0001556,biological_process oocyte maturation;GO:0001673,cellular_component male germ cell nucleus;GO:0003712,molecular_function transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006302,biological_process double-strand break repair;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007130,biological_process synaptonemal complex assembly;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007141,biological_process male meiosis I;GO:0007144,biological_process female meiosis I;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0030154,biological_process cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0048477,biological_process oogenesis;GO:0051321,biological_process meiotic cell cycle;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	thyroid hormone receptor interactor 13 [Source:HGNC Symbol%3BAcc:HGNC:12307]
ENSG00000105229	15.74	13.43	16.12	15.07	15.12	15.17	0.0175567221217242	4.54459635477377	0.894266435947026	0.983217827228559	19:4007645-4039386:+	PIAS4	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008022,molecular_function protein C-terminus binding;GO:0008270,molecular_function zinc ion binding;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0016055,biological_process Wnt signaling pathway;GO:0016363,cellular_component nuclear matrix;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0061665,molecular_function SUMO ligase activity;GO:1902174,biological_process positive regulation of keratinocyte apoptotic process;GO:1902231,biological_process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1990234,cellular_component transferase complex	PIAS4; E3 SUMO-protein ligase PIAS4 [EC:2.3.2.27]; K16065	protein inhibitor of activated STAT 4 [Source:HGNC Symbol%3BAcc:HGNC:17002]
ENSG00000138617	5.47	4.97	7.95	6.18	6.49	5.52	0.0398002649059803	2.62395029582971	0.894643428045679	0.983370592860609	15:65234459-65300618:-	PARP16	22;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006471,biological_process protein ADP-ribosylation;GO:0006986,biological_process response to unfolded protein;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019900,molecular_function kinase binding;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0060548,biological_process negative regulation of cell death;GO:0070213,biological_process protein auto-ADP-ribosylation;GO:0071782,cellular_component endoplasmic reticulum tubular network;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	poly(ADP-ribose) polymerase family member 16 [Source:HGNC Symbol%3BAcc:HGNC:26040]
ENSG00000173517	3.50	4.02	3.72	4.68	3.43	3.36	-0.0202779523872269	4.32035278346632	0.89464953479325	0.983370592860609	15:77100655-77420144:-	PEAK1	19;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0015629,cellular_component actin cytoskeleton;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030054,cellular_component cell junction;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0046777,biological_process protein autophosphorylation	NA	pseudopodium enriched atypical kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:29431]
ENSG00000113845	115.26	122.36	108.77	117.91	117.93	115.42	-0.0101675498842019	6.63941200935323	0.89476624883954	0.983370592860609	3:119498531-119525090:+	TIMMDC1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly	NA	translocase of inner mitochondrial membrane domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:1321]
ENSG00000111906	85.66	80.76	76.94	85.77	77.27	84.07	-0.0101417387424197	5.71243261501581	0.894775516979352	0.983370592860609	6:125219961-125302078:-	HDDC2	3;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0070062,cellular_component extracellular exosome	NA	HD domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:21078]
ENSG00000167272	20.94	25.80	23.48	23.58	24.82	21.28	0.0152570046584851	3.52496010536787	0.894877325912955	0.983370592860609	12:120578763-120581398:-	POP5	16;GO:0000172,cellular_component ribonuclease MRP complex;GO:0001682,biological_process tRNA 5'-leader removal;GO:0004526,molecular_function ribonuclease P activity;GO:0004540,molecular_function ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005655,cellular_component nucleolar ribonuclease P complex;GO:0005730,cellular_component nucleolus;GO:0008033,biological_process tRNA processing;GO:0009249,biological_process protein lipoylation;GO:0016070,biological_process RNA metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030681,cellular_component multimeric ribonuclease P complex;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]; K03537	POP5 homolog%2C ribonuclease P/MRP subunit [Source:HGNC Symbol%3BAcc:HGNC:17689]
ENSG00000265817	1.49	1.73	1.26	1.31	1.69	1.59	-0.0393165673629497	2.26440635916743	0.8950321414987	0.983370592860609	8:94372169-94436952:-	FSBP	6;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0042802,molecular_function identical protein binding	RAD54B; DNA repair and recombination protein RAD54B [EC:3.6.4.-]; K10877	fibrinogen silencer binding protein [Source:HGNC Symbol%3BAcc:HGNC:43653]
ENSG00000039319	7.34	6.57	7.36	6.81	7.29	7.55	-0.00933321355933798	5.06232091743619	0.895037679078151	0.983370592860609	5:80408012-80479350:+	ZFYVE16	18;GO:0005515,molecular_function protein binding;GO:0005545,molecular_function 1-phosphatidylinositol binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006622,biological_process protein targeting to lysosome;GO:0007165,biological_process signal transduction;GO:0008565,molecular_function protein transporter activity;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0016197,biological_process endosomal transport;GO:0030100,biological_process regulation of endocytosis;GO:0030509,biological_process BMP signaling pathway;GO:0031901,cellular_component early endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	MADHIP, SARA; MAD, mothers against decapentaplegic interacting protein; K04679	zinc finger FYVE-type containing 16 [Source:HGNC Symbol%3BAcc:HGNC:20756]
ENSG00000004455	155.90	154.43	152.26	155.90	150.66	162.55	-0.00869094185559008	6.98634605355755	0.895075351651705	0.983370592860609	1:33007939-33080996:-	AK2	20;GO:0000166,molecular_function nucleotide binding;GO:0004017,molecular_function adenylate kinase activity;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006172,biological_process ADP biosynthetic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016776,molecular_function phosphotransferase activity, phosphate group as acceptor;GO:0019205,molecular_function nucleobase-containing compound kinase activity;GO:0036126,cellular_component sperm flagellum;GO:0046033,biological_process AMP metabolic process;GO:0046034,biological_process ATP metabolic process;GO:0046939,biological_process nucleotide phosphorylation;GO:0070062,cellular_component extracellular exosome;GO:0097226,cellular_component sperm mitochondrial sheath	adk, AK; adenylate kinase [EC:2.7.4.3]; K00939	adenylate kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:362]
ENSG00000123815	18.30	18.80	18.58	18.99	19.83	17.75	-0.0113849148844922	4.95699781170003	0.89511837015484	0.983370592860609	19:40691528-40718207:-	COQ8B	14;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006744,biological_process ubiquinone biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0021692,biological_process cerebellar Purkinje cell layer morphogenesis;GO:0031966,cellular_component mitochondrial membrane	NA	coenzyme Q8B [Source:HGNC Symbol%3BAcc:HGNC:19041]
ENSG00000100784	8.60	8.02	8.94	7.53	8.30	9.71	0.01485394218018	4.47442238589598	0.895265641752914	0.983445346113178	14:90847861-91060636:-	RPS6KA5	32;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001818,biological_process negative regulation of cytokine production;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016572,biological_process histone phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0033129,biological_process positive regulation of histone phosphorylation;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035556,biological_process intracellular signal transduction;GO:0043987,biological_process histone H3-S10 phosphorylation;GO:0043988,biological_process histone H3-S28 phosphorylation;GO:0043990,biological_process histone H2A-S1 phosphorylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070498,biological_process interleukin-1-mediated signaling pathway	RPS6KA5, MSK1; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]; K04445	ribosomal protein S6 kinase A5 [Source:HGNC Symbol%3BAcc:HGNC:10434]
ENSG00000108091	16.54	14.18	14.34	14.37	15.41	15.28	0.0163320945676599	4.43014510074049	0.895691134141081	0.983694862636057	10:59788762-59906656:-	CCDC6	8;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0008150,biological_process biological_process;GO:0017124,molecular_function SH3 domain binding	CCDC6, PTC; coiled-coil domain-containing protein 6; K09288	coiled-coil domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:18782]
ENSG00000088888	21.06	20.82	20.63	21.17	20.79	20.62	0.0104898426025618	5.084986999557	0.895695210054251	0.983694862636057	20:3846798-3876123:+	MAVS	44;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002218,biological_process activation of innate immune response;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0019901,molecular_function protein kinase binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0033160,biological_process positive regulation of protein import into nucleus, translocation;GO:0035549,biological_process positive regulation of interferon-beta secretion;GO:0039529,biological_process RIG-I signaling pathway;GO:0042742,biological_process defense response to bacterium;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050700,molecular_function CARD domain binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051607,biological_process defense response to virus;GO:0060340,biological_process positive regulation of type I interferon-mediated signaling pathway;GO:0060760,biological_process positive regulation of response to cytokine stimulus;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0071651,biological_process positive regulation of chemokine (C-C motif) ligand 5 production;GO:0071660,biological_process positive regulation of IP-10 production;GO:1900063,biological_process regulation of peroxisome organization;GO:1902741,biological_process positive regulation of interferon-alpha secretion;GO:1904469,biological_process positive regulation of tumor necrosis factor secretion;GO:2000778,biological_process positive regulation of interleukin-6 secretion	MAVS, IPS1; mitochondrial antiviral-signaling protein; K12648	mitochondrial antiviral signaling protein [Source:HGNC Symbol%3BAcc:HGNC:29233]
ENSG00000136169	5.26	4.73	4.30	5.31	4.13	4.77	0.0216144699308247	3.43486491606811	0.895762175404868	0.983694862636057	13:49444373-49495003:+	SETDB2	24;GO:0000278,biological_process mitotic cell cycle;GO:0001947,biological_process heart looping;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007275,biological_process multicellular organism development;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046974,molecular_function histone methyltransferase activity (H3-K9 specific);GO:0051301,biological_process cell division;GO:0051567,biological_process histone H3-K9 methylation;GO:0070986,biological_process left/right axis specification	SETDB1; [histone H3]-lysine9 N-trimethyltransferase SETDB1 [EC:2.1.1.355]; K11421	SET domain bifurcated 2 [Source:HGNC Symbol%3BAcc:HGNC:20263]
ENSG00000026751	1.83	2.01	2.61	2.15	2.69	1.95	-0.0555469956835569	1.29725721507408	0.895809774207523	0.983694862636057	1:160739056-160754821:+	SLAMF7	11;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030101,biological_process natural killer cell activation;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0045087,biological_process innate immune response;GO:0050776,biological_process regulation of immune response	NA	SLAM family member 7 [Source:HGNC Symbol%3BAcc:HGNC:21394]
ENSG00000172331	20.63	23.74	19.23	20.52	21.77	20.91	0.0115735627966823	4.04663839196461	0.895901876750584	0.983708977983636	7:134646807-134679813:+	BPGM	16;GO:0003824,molecular_function catalytic activity;GO:0004082,molecular_function bisphosphoglycerate mutase activity;GO:0004619,molecular_function phosphoglycerate mutase activity;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0007585,biological_process respiratory gaseous exchange;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016853,molecular_function isomerase activity;GO:0016868,molecular_function intramolecular transferase activity, phosphotransferases;GO:0043456,biological_process regulation of pentose-phosphate shunt;GO:0046538,molecular_function 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome	BPGM; bisphosphoglycerate/phosphoglycerate mutase [EC:5.4.2.4 5.4.2.11]; K01837	bisphosphoglycerate mutase [Source:HGNC Symbol%3BAcc:HGNC:1093]
ENSG00000176155	7.16	5.87	7.31	6.41	6.81	7.54	-0.0109367802265848	4.7190051026402	0.896084673076727	0.983822664682595	17:82101459-82212830:-	CCDC57	1;GO:0005515,molecular_function protein binding	NA	coiled-coil domain containing 57 [Source:HGNC Symbol%3BAcc:HGNC:27564]
ENSG00000178105	11.52	10.91	10.55	10.73	11.04	11.23	0.0114941017687038	4.88966004990696	0.896391082443633	0.98407203558617	11:108665024-108940930:+	DDX10	11;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016787,molecular_function hydrolase activity	NA	DEAD-box helicase 10 [Source:HGNC Symbol%3BAcc:HGNC:2735]
ENSG00000133114	11.41	12.18	11.83	11.73	11.70	11.87	0.0126444016321359	3.87426404807087	0.896484477874917	0.984087533061668	13:44989528-45037669:+	GPALPP1	NA	NA	GPALPP motifs containing 1 [Source:HGNC Symbol%3BAcc:HGNC:20298]
ENSG00000176894	7.17	5.57	4.45	6.06	4.18	6.76	0.0285827091057898	2.44733575857218	0.896742034400558	0.984162566870018	12:132687605-132704991:+	PXMP2	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043234,cellular_component protein complex	PXMP2, PMP22; peroxisomal membrane protein 2; K13347	peroxisomal membrane protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9716]
ENSG00000176809	5.04	5.44	4.89	4.95	5.43	5.23	-0.0146461051073467	4.70954622149573	0.896771061046971	0.984162566870018	17:64854311-64919480:-	LRRC37A3	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	leucine rich repeat containing 37 member A3 [Source:HGNC Symbol%3BAcc:HGNC:32427]
ENSG00000129116	10.34	9.79	10.04	10.07	9.62	10.53	0.0104304806059836	5.38797315457747	0.896790686688695	0.984162566870018	4:168497065-168928457:+	PALLD	24;GO:0001726,cellular_component ruffle;GO:0002102,cellular_component podosome;GO:0003334,biological_process keratinocyte development;GO:0003382,biological_process epithelial cell morphogenesis;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007010,biological_process cytoskeleton organization;GO:0015629,cellular_component actin cytoskeleton;GO:0016477,biological_process cell migration;GO:0030018,cellular_component Z disc;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0042995,cellular_component cell projection;GO:0051371,molecular_function muscle alpha-actinin binding	NA	palladin%2C cytoskeletal associated protein [Source:HGNC Symbol%3BAcc:HGNC:17068]
ENSG00000180098	43.88	38.63	44.02	40.78	44.48	41.57	0.0140078743208476	5.19316610245708	0.896979985851093	0.984242363045585	1:28553084-28578545:+	TRNAU1AP	6;GO:0001514,biological_process selenocysteine incorporation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006412,biological_process translation	NA	tRNA selenocysteine 1 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:30813]
ENSG00000112245	148.41	138.58	158.85	158.71	135.37	158.89	-0.0099250578707799	6.61186186058639	0.897039630520176	0.984242363045585	6:63521747-63583587:+	PTP4A1	23;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030335,biological_process positive regulation of cell migration;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0070062,cellular_component extracellular exosome	NA	protein tyrosine phosphatase type IVA%2C member 1 [Source:HGNC Symbol%3BAcc:HGNC:9634]
ENSG00000189367	14.97	16.06	15.67	14.39	17.19	15.87	-0.0129305743021243	5.06107771918054	0.897101272496394	0.984242363045585	6:127440342-127459391:-	KIAA0408	1;GO:0005515,molecular_function protein binding	NA	KIAA0408 [Source:HGNC Symbol%3BAcc:HGNC:21636]
ENSG00000197978	5.40	3.98	6.19	5.03	5.09	5.97	-0.0206886856337805	2.81825294291691	0.897239461780987	0.984266423173164	15:82430017-82439153:+	GOLGA6L9	1;GO:0005794,cellular_component Golgi apparatus	NA	golgin A6 family-like 9 [Source:HGNC Symbol%3BAcc:HGNC:37229]
ENSG00000110700	728.55	672.73	672.51	738.45	624.04	714.64	0.00954400723566238	8.65742573426386	0.897453680255419	0.984266423173164	11:17074388-17077787:-	RPS13	26;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0033119,biological_process negative regulation of RNA splicing;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070062,cellular_component extracellular exosome;GO:0070181,molecular_function small ribosomal subunit rRNA binding;GO:1990932,molecular_function 5.8S rRNA binding	RP-S13e, RPS13; small subunit ribosomal protein S13e; K02953	ribosomal protein S13 [Source:HGNC Symbol%3BAcc:HGNC:10386]
ENSG00000118181	1387.90	1311.17	1365.27	1430.76	1295.50	1394.55	-0.00798610460236969	9.06787140582787	0.897497773225321	0.984266423173164	11:119015711-119018691:-	RPS25	18;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein S25 [Source:HGNC Symbol%3BAcc:HGNC:10413]
ENSG00000177606	150.00	122.61	147.87	153.29	124.80	142.55	0.0125985437370927	7.12489512252526	0.897562865845904	0.984266423173164	1:58780787-58784327:-	JUN	102;GO:0000228,cellular_component nuclear chromosome;GO:0000790,cellular_component nuclear chromatin;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001525,biological_process angiogenesis;GO:0001774,biological_process microglial cell activation;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0001889,biological_process liver development;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0003151,biological_process outflow tract morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005719,cellular_component nuclear euchromatin;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007184,biological_process SMAD protein import into nucleus;GO:0007265,biological_process Ras protein signal transduction;GO:0007568,biological_process aging;GO:0007612,biological_process learning;GO:0007623,biological_process circadian rhythm;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009314,biological_process response to radiation;GO:0009612,biological_process response to mechanical stimulus;GO:0009987,biological_process cellular process;GO:0010033,biological_process response to organic substance;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0014070,biological_process response to organic cyclic compound;GO:0017053,cellular_component transcriptional repressor complex;GO:0019899,molecular_function enzyme binding;GO:0030224,biological_process monocyte differentiation;GO:0031103,biological_process axon regeneration;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031953,biological_process negative regulation of protein autophosphorylation;GO:0032496,biological_process response to lipopolysaccharide;GO:0032870,biological_process cellular response to hormone stimulus;GO:0033613,molecular_function activating transcription factor binding;GO:0034097,biological_process response to cytokine;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035026,biological_process leading edge cell differentiation;GO:0035497,molecular_function cAMP response element binding;GO:0035976,cellular_component AP1 complex;GO:0035994,biological_process response to muscle stretch;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043392,biological_process negative regulation of DNA binding;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043922,biological_process negative regulation by host of viral transcription;GO:0043923,biological_process positive regulation by host of viral transcription;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045657,biological_process positive regulation of monocyte differentiation;GO:0045740,biological_process positive regulation of DNA replication;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051090,biological_process regulation of sequence-specific DNA binding transcription factor activity;GO:0051365,biological_process cellular response to potassium ion starvation;GO:0051591,biological_process response to cAMP;GO:0051726,biological_process regulation of cell cycle;GO:0051899,biological_process membrane depolarization;GO:0060395,biological_process SMAD protein signal transduction;GO:0061029,biological_process eyelid development in camera-type eye;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070412,molecular_function R-SMAD binding;GO:0071276,biological_process cellular response to cadmium ion;GO:0071277,biological_process cellular response to calcium ion;GO:0071837,molecular_function HMG box domain binding;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1990441,biological_process negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:2000144,biological_process positive regulation of DNA-templated transcription, initiation	JUN; transcription factor AP-1; K04448	Jun proto-oncogene%2C AP-1 transcription factor subunit [Source:HGNC Symbol%3BAcc:HGNC:6204]
ENSG00000204604	5.95	6.55	6.65	5.89	7.05	6.11	0.0181444373028747	3.66426226932537	0.89767015904637	0.984266423173164	19:52838007-52857649:-	ZNF468	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 468 [Source:HGNC Symbol%3BAcc:HGNC:33105]
ENSG00000163354	0.84	0.97	0.78	1.23	0.61	0.65	0.0523799771703599	1.09892443865804	0.897692747832676	0.984266423173164	1:155018519-155033781:-	DCST2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	DC-STAMP domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:26562]
ENSG00000185664	0.95	1.14	1.37	1.33	0.94	1.11	0.044219650056925	1.34130153560663	0.897827822190003	0.984266423173164	12:55954104-55973317:-	PMEL	16;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005768,cellular_component endosome;GO:0005771,cellular_component multivesicular body;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032438,biological_process melanosome organization;GO:0032585,cellular_component multivesicular body membrane;GO:0042438,biological_process melanin biosynthetic process;GO:0042470,cellular_component melanosome;GO:0048066,biological_process developmental pigmentation	NA	premelanosome protein [Source:HGNC Symbol%3BAcc:HGNC:10880]
ENSG00000051180	8.50	11.34	8.54	9.34	9.73	8.96	0.0150580374085906	3.43071741988385	0.897853180272271	0.984266423173164	15:40694773-40732339:+	RAD51	72;GO:0000150,molecular_function recombinase activity;GO:0000166,molecular_function nucleotide binding;GO:0000228,cellular_component nuclear chromosome;GO:0000400,molecular_function four-way junction DNA binding;GO:0000722,biological_process telomere maintenance via recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000730,biological_process DNA recombinase assembly;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0000793,cellular_component condensed chromosome;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000800,cellular_component lateral element;GO:0001932,biological_process regulation of protein phosphorylation;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006259,biological_process DNA metabolic process;GO:0006268,biological_process DNA unwinding involved in DNA replication;GO:0006281,biological_process DNA repair;GO:0006310,biological_process DNA recombination;GO:0006312,biological_process mitotic recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007127,biological_process meiosis I;GO:0007131,biological_process reciprocal meiotic recombination;GO:0008022,molecular_function protein C-terminus binding;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0009636,biological_process response to toxic substance;GO:0010165,biological_process response to X-ray;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0010833,biological_process telomere maintenance via telomere lengthening;GO:0014070,biological_process response to organic cyclic compound;GO:0016605,cellular_component PML body;GO:0031297,biological_process replication fork processing;GO:0032200,biological_process telomere organization;GO:0035861,cellular_component site of double-strand break;GO:0036297,biological_process interstrand cross-link repair;GO:0042148,biological_process strand invasion;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0043234,cellular_component protein complex;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051106,biological_process positive regulation of DNA ligation;GO:0051260,biological_process protein homooligomerization;GO:0051321,biological_process meiotic cell cycle;GO:0070182,molecular_function DNA polymerase binding;GO:0070192,biological_process chromosome organization involved in meiotic cell cycle;GO:0071312,biological_process cellular response to alkaloid;GO:0071479,biological_process cellular response to ionizing radiation;GO:0071480,biological_process cellular response to gamma radiation;GO:0072711,biological_process cellular response to hydroxyurea;GO:0072719,biological_process cellular response to cisplatin;GO:0072757,biological_process cellular response to camptothecin;GO:1904631,biological_process response to glucoside;GO:1990414,biological_process replication-born double-strand break repair via sister chromatid exchange;GO:1990426,biological_process mitotic recombination-dependent replication fork processing	RAD51; DNA repair protein RAD51; K04482	RAD51 recombinase [Source:HGNC Symbol%3BAcc:HGNC:9817]
ENSG00000149357	67.07	74.53	63.42	61.80	77.63	65.23	0.0113298732894049	5.44384689046331	0.897855905613017	0.984266423173164	11:72085894-72103387:-	LAMTOR1	34;GO:0001919,biological_process regulation of receptor recycling;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0007032,biological_process endosome organization;GO:0007040,biological_process lysosome organization;GO:0007050,biological_process cell cycle arrest;GO:0010872,biological_process regulation of cholesterol esterification;GO:0010874,biological_process regulation of cholesterol efflux;GO:0016020,cellular_component membrane;GO:0016049,biological_process cell growth;GO:0016241,biological_process regulation of macroautophagy;GO:0031902,cellular_component late endosome membrane;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032418,biological_process lysosome localization;GO:0032439,biological_process endosome localization;GO:0032947,molecular_function protein complex scaffold;GO:0034613,biological_process cellular protein localization;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0042632,biological_process cholesterol homeostasis;GO:0043312,biological_process neutrophil degranulation;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045121,cellular_component membrane raft;GO:0051020,molecular_function GTPase binding;GO:0060620,biological_process regulation of cholesterol import;GO:0070062,cellular_component extracellular exosome;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0071986,cellular_component Ragulator complex;GO:0101003,cellular_component ficolin-1-rich granule membrane	NA	late endosomal/lysosomal adaptor%2C MAPK and MTOR activator 1 [Source:HGNC Symbol%3BAcc:HGNC:26068]
ENSG00000180185	30.59	29.88	27.40	29.97	28.69	30.63	-0.0131918047430298	4.61084046717903	0.897916134376292	0.984266423173164	16:1826940-1840207:+	FAHD1	14;GO:0003824,molecular_function catalytic activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0008152,biological_process metabolic process;GO:0008948,molecular_function oxaloacetate decarboxylase activity;GO:0016787,molecular_function hydrolase activity;GO:0016829,molecular_function lyase activity;GO:0018773,molecular_function acetylpyruvate hydrolase activity;GO:0034545,molecular_function fumarylpyruvate hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0047621,molecular_function acylpyruvate hydrolase activity	FAHD1; acylpyruvate hydrolase [EC:3.7.1.5]; K01557	fumarylacetoacetate hydrolase domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:14169]
ENSG00000182473	34.33	37.12	37.02	36.33	37.19	36.46	-0.00939901203546266	6.43774809800104	0.898107828842842	0.984313319676585	17:76081016-76121576:-	EXOC7	15;GO:0000145,cellular_component exocyst;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0030496,cellular_component midbody;GO:0032584,cellular_component growth cone membrane;GO:0034451,cellular_component centriolar satellite;GO:2000535,biological_process regulation of entry of bacterium into host cell	EXOC7, EXO70; exocyst complex component 7; K07195	exocyst complex component 7 [Source:HGNC Symbol%3BAcc:HGNC:23214]
ENSG00000101230	2.13	3.36	2.64	3.55	2.62	2.22	-0.0481073307731757	1.98035934865762	0.898124018408221	0.984313319676585	20:13221770-13300651:+	ISM1	1;GO:0005576,cellular_component extracellular region	NA	isthmin 1 [Source:HGNC Symbol%3BAcc:HGNC:16213]
ENSG00000159166	2.84	2.27	2.28	1.97	2.58	2.76	0.0334382337408247	2.29965396107315	0.898196807538603	0.984313319676585	1:201373243-201399915:-	LAD1	6;GO:0005198,molecular_function structural molecule activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	NA	ladinin 1 [Source:HGNC Symbol%3BAcc:HGNC:6472]
ENSG00000105171	32.76	37.06	33.12	35.68	36.53	30.48	0.0116723054507032	4.76249973632893	0.898282557140272	0.984320390340943	19:29604016-29617237:+	POP4	19;GO:0000171,molecular_function ribonuclease MRP activity;GO:0000172,cellular_component ribonuclease MRP complex;GO:0001682,biological_process tRNA 5'-leader removal;GO:0003723,molecular_function RNA binding;GO:0004526,molecular_function ribonuclease P activity;GO:0004540,molecular_function ribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005655,cellular_component nucleolar ribonuclease P complex;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0006379,biological_process mRNA cleavage;GO:0008033,biological_process tRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0030677,cellular_component ribonuclease P complex;GO:0030681,cellular_component multimeric ribonuclease P complex;GO:0033204,molecular_function ribonuclease P RNA binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	POP4, RPP29; ribonuclease P protein subunit POP4 [EC:3.1.26.5]; K03538	POP4 homolog%2C ribonuclease P/MRP subunit [Source:HGNC Symbol%3BAcc:HGNC:30081]
ENSG00000198553	1.62	2.61	3.14	2.46	2.07	2.62	0.044245096013652	1.23688619307201	0.898631961476997	0.984369486042609	13:50015253-50020922:+	KCNRG	5;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0042802,molecular_function identical protein binding;GO:0051260,biological_process protein homooligomerization;GO:1902260,biological_process negative regulation of delayed rectifier potassium channel activity	NA	potassium channel regulator [Source:HGNC Symbol%3BAcc:HGNC:18893]
ENSG00000082898	98.43	95.30	97.52	97.19	98.45	99.52	-0.00723048440519384	8.3044946391468	0.898785896068006	0.984369486042609	2:61477848-61538626:-	XPO1	42;GO:0000054,biological_process ribosomal subunit export from nucleus;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0000056,biological_process ribosomal small subunit export from nucleus;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000776,cellular_component kinetochore;GO:0003723,molecular_function RNA binding;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005215,molecular_function transporter activity;GO:0005487,molecular_function nucleocytoplasmic transporter activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005642,cellular_component annulate lamellae;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0007062,biological_process sister chromatid cohesion;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0010824,biological_process regulation of centrosome duplication;GO:0015030,cellular_component Cajal body;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0019904,molecular_function protein domain specific binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031965,cellular_component nuclear membrane;GO:0034504,biological_process protein localization to nucleus;GO:0042176,biological_process regulation of protein catabolic process;GO:0042254,biological_process ribosome biogenesis;GO:0042493,biological_process response to drug;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043488,biological_process regulation of mRNA stability;GO:0043657,cellular_component host cell;GO:0046825,biological_process regulation of protein export from nucleus;GO:0051028,biological_process mRNA transport;GO:0075733,biological_process intracellular transport of virus	NA	exportin 1 [Source:HGNC Symbol%3BAcc:HGNC:12825]
ENSG00000086232	131.75	141.24	133.33	132.74	139.93	134.68	0.00758689138770032	8.18850433270941	0.898839136415753	0.984369486042609	7:6022243-6059230:-	EIF2AK1	30;GO:0000166,molecular_function nucleotide binding;GO:0002526,biological_process acute inflammatory response;GO:0003743,molecular_function translation initiation factor activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004694,molecular_function eukaryotic translation initiation factor 2alpha kinase activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0006909,biological_process phagocytosis;GO:0006950,biological_process response to stress;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009605,biological_process response to external stimulus;GO:0010998,biological_process regulation of translational initiation by eIF2 alpha phosphorylation;GO:0010999,biological_process regulation of eIF2 alpha phosphorylation by heme;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0017148,biological_process negative regulation of translation;GO:0020037,molecular_function heme binding;GO:0030225,biological_process macrophage differentiation;GO:0042803,molecular_function protein homodimerization activity;GO:0045993,biological_process negative regulation of translational initiation by iron;GO:0046501,biological_process protoporphyrinogen IX metabolic process;GO:0046777,biological_process protein autophosphorylation;GO:0046984,biological_process regulation of hemoglobin biosynthetic process;GO:0046986,biological_process negative regulation of hemoglobin biosynthetic process;GO:0055072,biological_process iron ion homeostasis	EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]; K16194	eukaryotic translation initiation factor 2 alpha kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:24921]
ENSG00000133056	5.72	6.10	6.69	5.85	6.72	5.94	0.0125305249284628	5.00306799565756	0.898853796112223	0.984369486042609	1:204422627-204494724:-	PIK3C2B	32;GO:0000166,molecular_function nucleotide binding;GO:0001727,molecular_function lipid kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005942,cellular_component phosphatidylinositol 3-kinase complex;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008150,biological_process biological_process;GO:0009267,biological_process cellular response to starvation;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030139,cellular_component endocytic vesicle;GO:0035005,molecular_function 1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0035091,molecular_function phosphatidylinositol binding;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043491,biological_process protein kinase B signaling;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:1905037,biological_process autophagosome organization	PIK3C2; phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]; K00923	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [Source:HGNC Symbol%3BAcc:HGNC:8972]
ENSG00000074657	6.31	5.88	7.26	6.97	6.37	6.49	-0.0103673227736433	4.75639262420321	0.898870614346141	0.984369486042609	18:58862599-58986480:+	ZNF532	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 532 [Source:HGNC Symbol%3BAcc:HGNC:30940]
ENSG00000162909	208.85	222.03	216.29	220.41	216.24	219.18	-0.00765475883325033	8.83647611983399	0.899035593248226	0.984369486042609	1:223701592-223776018:+	CAPN2	35;GO:0000785,cellular_component chromatin;GO:0001666,biological_process response to hypoxia;GO:0001824,biological_process blastocyst development;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006508,biological_process proteolysis;GO:0007520,biological_process myoblast fusion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016540,biological_process protein autoprocessing;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030425,cellular_component dendrite;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031143,cellular_component pseudopodium;GO:0045121,cellular_component membrane raft;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0071230,biological_process cellular response to amino acid stimulus;GO:0097038,cellular_component perinuclear endoplasmic reticulum	CAPN2; calpain-2 [EC:3.4.22.53]; K03853	calpain 2 [Source:HGNC Symbol%3BAcc:HGNC:1479]
ENSG00000142208	87.90	91.83	86.15	91.27	87.34	90.88	-0.00880910278144979	7.05118742663333	0.899181814064912	0.984369486042609	14:104769348-104795751:-	AKT1	182;GO:0000060,biological_process protein import into nucleus, translocation;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0001649,biological_process osteoblast differentiation;GO:0001893,biological_process maternal placenta development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0005979,biological_process regulation of glycogen biosynthetic process;GO:0006006,biological_process glucose metabolic process;GO:0006412,biological_process translation;GO:0006417,biological_process regulation of translation;GO:0006464,biological_process cellular protein modification process;GO:0006468,biological_process protein phosphorylation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0006924,biological_process activation-induced cell death of T cells;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007275,biological_process multicellular organism development;GO:0007281,biological_process germ cell development;GO:0007399,biological_process nervous system development;GO:0007568,biological_process aging;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0008643,biological_process carbohydrate transport;GO:0009408,biological_process response to heat;GO:0009725,biological_process response to hormone;GO:0010033,biological_process response to organic substance;GO:0010507,biological_process negative regulation of autophagy;GO:0010629,biological_process negative regulation of gene expression;GO:0010748,biological_process negative regulation of plasma membrane long-chain fatty acid transport;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0010765,biological_process positive regulation of sodium ion transport;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0010918,biological_process positive regulation of mitochondrial membrane potential;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0010975,biological_process regulation of neuron projection development;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0015630,cellular_component microtubule cytoskeleton;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016242,biological_process negative regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0021510,biological_process spinal cord development;GO:0030030,biological_process cell projection organization;GO:0030154,biological_process cell differentiation;GO:0030163,biological_process protein catabolic process;GO:0030168,biological_process platelet activation;GO:0030212,biological_process hyaluronan metabolic process;GO:0030235,molecular_function nitric-oxide synthase regulator activity;GO:0030307,biological_process positive regulation of cell growth;GO:0030334,biological_process regulation of cell migration;GO:0031018,biological_process endocrine pancreas development;GO:0031295,biological_process T cell costimulation;GO:0031641,biological_process regulation of myelination;GO:0031659,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0031929,biological_process TOR signaling;GO:0031982,cellular_component vesicle;GO:0031999,biological_process negative regulation of fatty acid beta-oxidation;GO:0032079,biological_process positive regulation of endodeoxyribonuclease activity;GO:0032094,biological_process response to food;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032287,biological_process peripheral nervous system myelin maintenance;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032794,molecular_function GTPase activating protein binding;GO:0032869,biological_process cellular response to insulin stimulus;GO:0032880,biological_process regulation of protein localization;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034405,biological_process response to fluid shear stress;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035556,biological_process intracellular signal transduction;GO:0035655,biological_process interleukin-18-mediated signaling pathway;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0036064,cellular_component ciliary basal body;GO:0036294,biological_process cellular response to decreased oxygen levels;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043234,cellular_component protein complex;GO:0043276,biological_process anoikis;GO:0043325,molecular_function phosphatidylinositol-3,4-bisphosphate binding;GO:0043488,biological_process regulation of mRNA stability;GO:0043491,biological_process protein kinase B signaling;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045725,biological_process positive regulation of glycogen biosynthetic process;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0045792,biological_process negative regulation of cell size;GO:0045861,biological_process negative regulation of proteolysis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046326,biological_process positive regulation of glucose import;GO:0046329,biological_process negative regulation of JNK cascade;GO:0046622,biological_process positive regulation of organ growth;GO:0046777,biological_process protein autophosphorylation;GO:0046889,biological_process positive regulation of lipid biosynthetic process;GO:0048009,biological_process insulin-like growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051146,biological_process striated muscle cell differentiation;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0060416,biological_process response to growth hormone;GO:0060644,biological_process mammary gland epithelial cell differentiation;GO:0060709,biological_process glycogen cell differentiation involved in embryonic placenta development;GO:0060716,biological_process labyrinthine layer blood vessel development;GO:0061024,biological_process membrane organization;GO:0070141,biological_process response to UV-A;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071276,biological_process cellular response to cadmium ion;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0071380,biological_process cellular response to prostaglandin E stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071456,biological_process cellular response to hypoxia;GO:0071889,molecular_function 14-3-3 protein binding;GO:0072655,biological_process establishment of protein localization to mitochondrion;GO:0072656,biological_process maintenance of protein location in mitochondrion;GO:0090004,biological_process positive regulation of establishment of protein localization to plasma membrane;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097011,biological_process cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:0097194,biological_process execution phase of apoptosis;GO:0098794,cellular_component postsynapse;GO:0099565,biological_process chemical synaptic transmission, postsynaptic;GO:0100002,biological_process negative regulation of protein kinase activity by protein phosphorylation;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:1901215,biological_process negative regulation of neuron death;GO:1901653,biological_process cellular response to peptide;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1901976,biological_process regulation of cell cycle checkpoint;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1903721,biological_process positive regulation of I-kappaB phosphorylation;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:1990418,biological_process response to insulin-like growth factor stimulus;GO:2001240,biological_process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]; K04456	AKT serine/threonine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:391]
ENSG00000163874	6.80	6.00	5.99	6.09	5.58	7.02	0.0203166169527694	3.62327632241313	0.899192073262898	0.984369486042609	1:37474551-37484379:+	ZC3H12A	92;GO:0000294,biological_process nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001525,biological_process angiogenesis;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0004532,molecular_function exoribonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0010468,biological_process regulation of gene expression;GO:0010508,biological_process positive regulation of autophagy;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010656,biological_process negative regulation of muscle cell apoptotic process;GO:0010884,biological_process positive regulation of lipid storage;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030154,biological_process cell differentiation;GO:0030867,cellular_component rough endoplasmic reticulum membrane;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0034599,biological_process cellular response to oxidative stress;GO:0035198,molecular_function miRNA binding;GO:0035613,molecular_function RNA stem-loop binding;GO:0035925,molecular_function mRNA 3'-UTR AU-rich region binding;GO:0042149,biological_process cellular response to glucose starvation;GO:0042307,biological_process positive regulation of protein import into nucleus;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0042406,cellular_component extrinsic component of endoplasmic reticulum membrane;GO:0043022,molecular_function ribosome binding;GO:0043031,biological_process negative regulation of macrophage activation;GO:0043124,biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0044828,biological_process negative regulation by host of viral genome replication;GO:0045019,biological_process negative regulation of nitric oxide biosynthetic process;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0050713,biological_process negative regulation of interleukin-1 beta secretion;GO:0051259,biological_process protein oligomerization;GO:0051607,biological_process defense response to virus;GO:0055118,biological_process negative regulation of cardiac muscle contraction;GO:0061014,biological_process positive regulation of mRNA catabolic process;GO:0061158,biological_process 3'-UTR-mediated mRNA destabilization;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071347,biological_process cellular response to interleukin-1;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0098586,biological_process cellular response to virus;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response;GO:1900119,biological_process positive regulation of execution phase of apoptosis;GO:1900165,biological_process negative regulation of interleukin-6 secretion;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1902714,biological_process negative regulation of interferon-gamma secretion;GO:1903003,biological_process positive regulation of protein deubiquitination;GO:1903799,biological_process negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:1903936,biological_process cellular response to sodium arsenite;GO:1904468,biological_process negative regulation of tumor necrosis factor secretion;GO:1904628,biological_process cellular response to phorbol 13-acetate 12-myristate;GO:1904637,biological_process cellular response to ionomycin;GO:1990869,biological_process cellular response to chemokine;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2000627,biological_process positive regulation of miRNA catabolic process	NA	zinc finger CCCH-type containing 12A [Source:HGNC Symbol%3BAcc:HGNC:26259]
ENSG00000105879	20.96	18.95	20.46	19.71	20.68	20.11	0.0133553388568256	4.92018165681824	0.899311460715065	0.984369486042609	7:107743696-107761667:+	CBLL1	18;GO:0000151,cellular_component ubiquitin ligase complex;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0007162,biological_process negative regulation of cell adhesion;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0030155,biological_process regulation of cell adhesion;GO:0030335,biological_process positive regulation of cell migration;GO:0035635,biological_process entry of bacterium into host cell;GO:0042802,molecular_function identical protein binding;GO:0045807,biological_process positive regulation of endocytosis;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	Cbl proto-oncogene like 1 [Source:HGNC Symbol%3BAcc:HGNC:21225]
ENSG00000034693	26.07	25.79	24.20	25.56	25.82	24.70	0.0108508912881641	4.83441253299405	0.899391699039097	0.984369486042609	6:143450806-143490010:+	PEX3	17;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007031,biological_process peroxisome organization;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016557,biological_process peroxisome membrane biogenesis;GO:0032994,cellular_component protein-lipid complex;GO:0043234,cellular_component protein complex;GO:0045046,biological_process protein import into peroxisome membrane;GO:0046983,molecular_function protein dimerization activity;GO:0055085,biological_process transmembrane transport	PEX3; peroxin-3; K13336	peroxisomal biogenesis factor 3 [Source:HGNC Symbol%3BAcc:HGNC:8858]
ENSG00000128881	4.39	2.85	3.67	3.76	3.57	3.58	0.0228231320171557	4.21535546822293	0.899553773603094	0.984369486042609	15:42738733-42920809:-	TTBK2	29;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005882,cellular_component intermediate filament;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0007224,biological_process smoothened signaling pathway;GO:0008360,biological_process regulation of cell shape;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030030,biological_process cell projection organization;GO:0035869,cellular_component ciliary transition zone;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0045095,cellular_component keratin filament;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	tau tubulin kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:19141]
ENSG00000181381	4.17	3.61	4.39	4.35	3.78	4.04	0.0187998177864242	4.3950998848045	0.899619593846311	0.984369486042609	4:168356734-168537786:-	DDX60L	6;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0016787,molecular_function hydrolase activity	NA	DEAD-box helicase 60 like [Source:HGNC Symbol%3BAcc:HGNC:26429]
ENSG00000129691	17.52	15.05	16.54	16.60	16.63	16.01	0.0142034185906219	5.04964400591445	0.899805091586278	0.984369486042609	8:38105241-38144076:+	ASH2L	27;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005719,cellular_component nuclear euchromatin;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008013,molecular_function beta-catenin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030097,biological_process hemopoiesis;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0043627,biological_process response to estrogen;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044666,cellular_component MLL3/4 complex;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation;GO:0071339,cellular_component MLL1 complex;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:1990188,molecular_function euchromatin binding	ASH2; Set1/Ash2 histone methyltransferase complex subunit ASH2; K14964	ASH2 like histone lysine methyltransferase complex subunit [Source:HGNC Symbol%3BAcc:HGNC:744]
ENSG00000125633	15.98	16.59	17.25	16.75	15.65	18.21	-0.0122531177181035	5.04250412043843	0.899840405966789	0.984369486042609	2:117915477-118014133:-	CCDC93	6;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0015031,biological_process protein transport	NA	coiled-coil domain containing 93 [Source:HGNC Symbol%3BAcc:HGNC:25611]
ENSG00000102038	54.89	56.88	56.13	55.01	56.12	57.22	0.00737940695763359	7.50241284317989	0.899913775704279	0.984369486042609	X:129446500-129523500:-	SMARCA1	30;GO:0000166,molecular_function nucleotide binding;GO:0000733,biological_process DNA strand renaturation;GO:0000790,cellular_component nuclear chromatin;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007420,biological_process brain development;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008134,molecular_function transcription factor binding;GO:0016569,biological_process covalent chromatin modification;GO:0016589,cellular_component NURF complex;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0016887,molecular_function ATPase activity;GO:0030182,biological_process neuron differentiation;GO:0031491,molecular_function nucleosome binding;GO:0036310,molecular_function annealing helicase activity;GO:0043044,biological_process ATP-dependent chromatin remodeling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0070615,molecular_function nucleosome-dependent ATPase activity;GO:0090537,cellular_component CERF complex;GO:2000177,biological_process regulation of neural precursor cell proliferation	NA	SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 1 [Source:HGNC Symbol%3BAcc:HGNC:11097]
ENSG00000069020	0.34	0.33	0.27	0.36	0.30	0.33	-0.0436552265769877	1.51105020563945	0.899950015008438	0.984369486042609	5:66596360-67169595:+	MAST4	14;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	microtubule associated serine/threonine kinase family member 4 [Source:HGNC Symbol%3BAcc:HGNC:19037]
ENSG00000135045	20.02	17.57	15.93	20.84	16.03	16.31	0.0238899472875864	3.39407556246064	0.899957230277887	0.984369486042609	9:74946580-74952886:-	C9orf40	NA	NA	chromosome 9 open reading frame 40 [Source:HGNC Symbol%3BAcc:HGNC:23433]
ENSG00000165868	15.74	13.97	14.53	14.48	14.60	15.26	0.0125652929001542	5.03270137685842	0.899957908492764	0.984369486042609	10:116671191-116849741:-	HSPA12A	5;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0005524,molecular_function ATP binding;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome	NA	heat shock protein family A (Hsp70) member 12A [Source:HGNC Symbol%3BAcc:HGNC:19022]
ENSG00000083857	28.64	29.04	28.49	28.48	30.12	28.72	-0.00744826375738619	8.66417828875423	0.900118895467396	0.984369486042609	4:186587782-186726722:-	FAT1	23;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0007015,biological_process actin filament organization;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007163,biological_process establishment or maintenance of cell polarity;GO:0007267,biological_process cell-cell signaling;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016477,biological_process cell migration;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	FAT atypical cadherin 1 [Source:HGNC Symbol%3BAcc:HGNC:3595]
ENSG00000122958	102.45	102.19	96.11	96.55	99.35	105.44	0.00812155153021512	6.62414661671666	0.900172762106812	0.984369486042609	10:69123511-69172861:+	VPS26A	21;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008565,molecular_function protein transporter activity;GO:0010008,cellular_component endosome membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016241,biological_process regulation of macroautophagy;GO:0030904,cellular_component retromer complex;GO:0030906,cellular_component retromer, cargo-selective complex;GO:0031982,cellular_component vesicle;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0070062,cellular_component extracellular exosome;GO:0097422,cellular_component tubular endosome;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	VPS26%2C retromer complex component A [Source:HGNC Symbol%3BAcc:HGNC:12711]
ENSG00000204220	97.84	100.39	92.68	94.11	98.98	101.93	-0.0111662012545336	5.41739548165913	0.90017996354352	0.984369486042609	6:33289301-33298401:+	PFDN6	6;GO:0005737,cellular_component cytoplasm;GO:0006457,biological_process protein folding;GO:0016272,cellular_component prefoldin complex;GO:0051082,molecular_function unfolded protein binding;GO:0051087,molecular_function chaperone binding;GO:0051131,biological_process chaperone-mediated protein complex assembly	NA	prefoldin subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:4926]
ENSG00000185651	150.73	161.29	150.42	156.75	167.81	144.56	-0.00985805716200691	6.68794604391526	0.900213039131642	0.984369486042609	22:21549446-21624034:+	UBE2L3	31;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008283,biological_process cell proliferation;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0019899,molecular_function enzyme binding;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0044770,biological_process cell cycle phase transition;GO:0051443,biological_process positive regulation of ubiquitin-protein transferase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070062,cellular_component extracellular exosome;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0071383,biological_process cellular response to steroid hormone stimulus;GO:0071385,biological_process cellular response to glucocorticoid stimulus;GO:0097027,molecular_function ubiquitin-protein transferase activator activity;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	UBE2L3, UBCH7; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]; K04552	ubiquitin conjugating enzyme E2 L3 [Source:HGNC Symbol%3BAcc:HGNC:12488]
ENSG00000157764	6.44	6.30	6.37	6.64	6.12	6.71	-0.0149785595376951	3.94457947782644	0.90022296859533	0.984369486042609	7:140719326-140924764:-	BRAF	69;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0002318,biological_process myeloid progenitor cell differentiation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0008542,biological_process visual learning;GO:0009887,biological_process organ morphogenesis;GO:0009968,biological_process negative regulation of signal transduction;GO:0010628,biological_process positive regulation of gene expression;GO:0010764,biological_process negative regulation of fibroblast migration;GO:0015758,biological_process glucose transport;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0030878,biological_process thyroid gland development;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035556,biological_process intracellular signal transduction;GO:0035690,biological_process cellular response to drug;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0043005,cellular_component neuron projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043367,biological_process CD4-positive, alpha-beta T cell differentiation;GO:0043368,biological_process positive T cell selection;GO:0043369,biological_process CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0043434,biological_process response to peptide hormone;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044297,cellular_component cell body;GO:0045580,biological_process regulation of T cell differentiation;GO:0046632,biological_process alpha-beta T cell differentiation;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048538,biological_process thymus development;GO:0048679,biological_process regulation of axon regeneration;GO:0048680,biological_process positive regulation of axon regeneration;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051291,biological_process protein heterooligomerization;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051591,biological_process response to cAMP;GO:0060291,biological_process long-term synaptic potentiation;GO:0060323,biological_process head morphogenesis;GO:0060324,biological_process face development;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071277,biological_process cellular response to calcium ion;GO:0090150,biological_process establishment of protein localization to membrane;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000301,biological_process negative regulation of synaptic vesicle exocytosis;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]; K04365	B-Raf proto-oncogene%2C serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:1097]
ENSG00000115073	54.35	50.15	56.64	55.29	50.43	57.98	-0.00877566544303711	5.93835621163366	0.900250066030105	0.984369486042609	2:97655962-97664107:-	ACTR1B	17;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005869,cellular_component dynactin complex;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	ARP1 actin related protein 1 homolog B [Source:HGNC Symbol%3BAcc:HGNC:168]
ENSG00000078124	6.68	5.93	5.96	6.30	5.58	6.58	0.0234910137783275	2.59429079112492	0.900309898899681	0.984369486042609	11:76860866-77026797:+	ACER3	16;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006672,biological_process ceramide metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0016811,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0030173,cellular_component integral component of Golgi membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0046512,biological_process sphingosine biosynthetic process;GO:0070774,molecular_function phytoceramidase activity;GO:0071602,biological_process phytosphingosine biosynthetic process	ACER3, YDC1; dihydroceramidase [EC:3.5.1.-]; K04711	alkaline ceramidase 3 [Source:HGNC Symbol%3BAcc:HGNC:16066]
ENSG00000069493	19.35	14.74	20.87	19.54	14.75	22.10	-0.0193084841485768	3.99196308147306	0.900492323384691	0.984482227424183	12:9664968-9699555:+	CLEC2D	10;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030246,molecular_function carbohydrate binding;GO:0050776,biological_process regulation of immune response	NA	C-type lectin domain family 2 member D [Source:HGNC Symbol%3BAcc:HGNC:14351]
ENSG00000217128	15.71	15.03	16.28	15.13	16.76	15.86	-0.0081379070786428	5.79558800439163	0.900823290139301	0.984706335369819	5:131641713-131797063:-	FNIP1	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002327,biological_process immature B cell differentiation;GO:0002904,biological_process positive regulation of B cell apoptotic process;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0009267,biological_process cellular response to starvation;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031929,biological_process TOR signaling;GO:0032007,biological_process negative regulation of TOR signaling;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0042030,molecular_function ATPase inhibitor activity;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051087,molecular_function chaperone binding;GO:2000973,biological_process regulation of pro-B cell differentiation	NA	folliculin interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:29418]
ENSG00000123154	14.37	12.96	14.83	14.66	14.55	13.90	-0.0121890228038172	3.89312536256307	0.900861099099266	0.984706335369819	19:12666799-12675832:+	WDR83	13;GO:0000165,biological_process MAPK cascade;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005737,cellular_component cytoplasm;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0010008,cellular_component endosome membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	WD repeat domain 83 [Source:HGNC Symbol%3BAcc:HGNC:32672]
ENSG00000237765	9.50	8.29	8.55	9.08	7.85	9.38	0.0165545259003937	4.12878354090061	0.900935297735844	0.984706335369819	4:15681661-15705565:+	FAM200B	6;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter	NA	family with sequence similarity 200 member B [Source:HGNC Symbol%3BAcc:HGNC:27740]
ENSG00000072201	2.82	2.23	2.17	2.43	2.43	2.56	-0.0221308262818256	2.51937852502686	0.901208133874695	0.984838532654522	4:53459300-53701405:-	LNX1	10;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030165,molecular_function PDZ domain binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization	NA	ligand of numb-protein X 1 [Source:HGNC Symbol%3BAcc:HGNC:6657]
ENSG00000178752	8.38	4.02	6.87	8.31	3.95	7.75	-0.0342393266287986	3.01061784949428	0.901307594573798	0.984838532654522	2:238158981-238168900:+	ERFE	8;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0006879,biological_process cellular iron ion homeostasis;GO:0019217,biological_process regulation of fatty acid metabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:2000193,biological_process positive regulation of fatty acid transport	NA	erythroferrone [Source:HGNC Symbol%3BAcc:HGNC:26727]
ENSG00000138303	34.88	30.69	32.29	33.44	30.94	33.72	0.0115152107016751	5.51702882152738	0.901392631191517	0.984838532654522	10:72096031-72217134:-	ASCC1	10;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006307,biological_process DNA dealkylation involved in DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0031594,cellular_component neuromuscular junction	NA	activating signal cointegrator 1 complex subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:24268]
ENSG00000166479	25.09	19.19	22.42	24.04	20.67	23.30	-0.00990500346026092	5.05054621732093	0.901395973794543	0.984838532654522	18:68673687-68715298:-	TMX3	17;GO:0002576,biological_process platelet degranulation;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005623,cellular_component cell;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016853,molecular_function isomerase activity;GO:0016972,molecular_function thiol oxidase activity;GO:0018171,biological_process peptidyl-cysteine oxidation;GO:0031092,cellular_component platelet alpha granule membrane;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0045454,biological_process cell redox homeostasis	NA	thioredoxin related transmembrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:24718]
ENSG00000196417	3.05	2.91	3.42	3.35	2.81	3.46	-0.0229684663344711	2.5604550373556	0.901452945139827	0.984838532654522	19:53389792-53430413:+	ZNF765	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 765 [Source:HGNC Symbol%3BAcc:HGNC:25092]
ENSG00000114520	25.16	23.71	25.46	25.57	24.78	24.17	0.0120149745690883	5.07409295954503	0.901609728997522	0.984845251070456	3:125446643-125520197:-	SNX4	22;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0019898,cellular_component extrinsic component of membrane;GO:0031201,cellular_component SNARE complex;GO:0031901,cellular_component early endosome membrane;GO:0032456,biological_process endocytic recycling;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043234,cellular_component protein complex;GO:1903595,biological_process positive regulation of histamine secretion by mast cell;GO:1990459,molecular_function transferrin receptor binding;GO:1990460,molecular_function leptin receptor binding	NA	sorting nexin 4 [Source:HGNC Symbol%3BAcc:HGNC:11175]
ENSG00000167333	5.71	6.35	6.91	6.67	5.72	6.46	0.0187874298523257	3.2250271651598	0.901617774362737	0.984845251070456	11:4598671-4608259:-	TRIM68	17;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0035035,molecular_function histone acetyltransferase binding;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050681,molecular_function androgen receptor binding;GO:0051865,biological_process protein autoubiquitination;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060765,biological_process regulation of androgen receptor signaling pathway	NA	tripartite motif containing 68 [Source:HGNC Symbol%3BAcc:HGNC:21161]
ENSG00000108829	45.11	48.36	38.52	42.63	48.50	40.70	0.0108741577157389	5.66785349233249	0.90169830444606	0.984846551085697	17:50375058-50397553:-	LRRC59	11;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031090,cellular_component organelle membrane;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045296,molecular_function cadherin binding	NA	leucine rich repeat containing 59 [Source:HGNC Symbol%3BAcc:HGNC:28817]
ENSG00000175606	52.22	55.17	51.94	56.11	51.35	54.10	-0.0110751467640359	5.4277973767663	0.902129046455012	0.985230323213625	8:73972436-73982783:+	TMEM70	8;GO:0003674,molecular_function molecular_function;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032592,cellular_component integral component of mitochondrial membrane;GO:0033615,biological_process mitochondrial proton-transporting ATP synthase complex assembly	NA	transmembrane protein 70 [Source:HGNC Symbol%3BAcc:HGNC:26050]
ENSG00000188613	0.56	1.20	0.42	0.34	0.35	1.28	0.0734958952529159	-0.419688891472599	0.902339749443043	0.985373740638382	10:119029715-119033732:+	NANOS1	16;GO:0001558,biological_process regulation of cell growth;GO:0001894,biological_process tissue homeostasis;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0006417,biological_process regulation of translation;GO:0008270,molecular_function zinc ion binding;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0010631,biological_process epithelial cell migration;GO:0016477,biological_process cell migration;GO:0017148,biological_process negative regulation of translation;GO:0030371,molecular_function translation repressor activity;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0098749,biological_process cerebellar neuron development;GO:1900153,biological_process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	NA	nanos C2HC-type zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:23044]
ENSG00000120314	17.24	20.99	18.39	18.89	19.25	19.28	-0.017282163489215	4.55228098546209	0.902437644668353	0.985393955248792	5:140664675-140674124:+	WDR55	8;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0008150,biological_process biological_process;GO:0042273,biological_process ribosomal large subunit biogenesis	NA	WD repeat domain 55 [Source:HGNC Symbol%3BAcc:HGNC:25971]
ENSG00000166140	12.79	13.58	14.57	15.04	13.25	13.35	-0.0126996163134903	4.57276030431877	0.903052905082702	0.98597904044257	15:40807085-40815084:+	ZFYVE19	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0008289,molecular_function lipid binding;GO:0009838,biological_process abscission;GO:0030496,cellular_component midbody;GO:0032154,cellular_component cleavage furrow;GO:0032266,molecular_function phosphatidylinositol-3-phosphate binding;GO:0032466,biological_process negative regulation of cytokinesis;GO:0044878,biological_process mitotic cytokinesis checkpoint;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	NA	zinc finger FYVE-type containing 19 [Source:HGNC Symbol%3BAcc:HGNC:20758]
ENSG00000196535	6.61	6.81	7.08	6.75	6.86	6.94	0.00822843026080394	5.85926652485237	0.903204021888814	0.986044676367356	17:29071123-29180412:-	MYO18A	30;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003774,molecular_function motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005856,cellular_component cytoskeleton;GO:0006259,biological_process DNA metabolic process;GO:0007030,biological_process Golgi organization;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016459,cellular_component myosin complex;GO:0016477,biological_process cell migration;GO:0031032,biological_process actomyosin structure organization;GO:0042641,cellular_component actomyosin;GO:0043030,biological_process regulation of macrophage activation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043531,molecular_function ADP binding;GO:0048194,biological_process Golgi vesicle budding;GO:0050714,biological_process positive regulation of protein secretion;GO:0051015,molecular_function actin filament binding;GO:0090161,biological_process Golgi ribbon formation;GO:0090164,biological_process asymmetric Golgi ribbon formation;GO:1903028,biological_process positive regulation of opsonization	NA	myosin XVIIIA [Source:HGNC Symbol%3BAcc:HGNC:31104]
ENSG00000198105	10.85	13.20	12.94	10.92	14.76	11.15	0.0150881899156094	4.47821688875517	0.903271893577153	0.986044676367356	10:37776525-37858106:-	ZNF248	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 248 [Source:HGNC Symbol%3BAcc:HGNC:13041]
ENSG00000154102	60.68	59.90	63.49	60.37	56.35	70.81	-0.0160353715427222	4.15198228441531	0.903378421195037	0.986074247475729	16:85690083-85751129:-	C16orf74	1;GO:0005515,molecular_function protein binding	NA	chromosome 16 open reading frame 74 [Source:HGNC Symbol%3BAcc:HGNC:23362]
ENSG00000104450	6.03	6.95	5.60	6.03	6.37	6.07	0.0109694563599466	4.18522451625325	0.903513863929393	0.986116920769242	8:100157905-100259278:+	SPAG1	7;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007338,biological_process single fertilization;GO:0016787,molecular_function hydrolase activity;GO:0070286,biological_process axonemal dynein complex assembly	NA	sperm associated antigen 1 [Source:HGNC Symbol%3BAcc:HGNC:11212]
ENSG00000277791	158.13	174.04	148.64	166.91	170.18	150.58	-0.0105468630937136	6.63518079152822	0.903576400292384	0.986116920769242	17:38752735-38764231:+	PSMB3	40;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMB3; 20S proteasome subunit beta 3 [EC:3.4.25.1]; K02735	proteasome subunit beta 3 [Source:HGNC Symbol%3BAcc:HGNC:9540]
ENSG00000078967	9.94	14.68	10.01	12.34	11.53	10.24	0.0161394597850747	2.85605648572955	0.903909952885318	0.986394219355205	7:43926437-43956136:+	UBE2D4	13;GO:0000166,molecular_function nucleotide binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0035519,biological_process protein K29-linked ubiquitination;GO:0044314,biological_process protein K27-linked ubiquitination;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination;GO:0085020,biological_process protein K6-linked ubiquitination	UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]; K06689	ubiquitin conjugating enzyme E2 D4 (putative) [Source:HGNC Symbol%3BAcc:HGNC:21647]
ENSG00000083544	5.18	5.80	6.58	5.98	5.72	5.80	0.0154764141532633	3.75978933253007	0.904064706545086	0.986476371514078	13:60396456-60573878:+	TDRD3	10;GO:0003682,molecular_function chromatin binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016569,biological_process covalent chromatin modification;GO:0035064,molecular_function methylated histone binding;GO:0035145,cellular_component exon-exon junction complex;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	tudor domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:20612]
ENSG00000171617	8.79	8.87	7.83	7.08	9.79	8.52	0.0163015062439678	3.91860908497332	0.904359891242532	0.986670073549915	5:74627405-74641424:-	ENC1	17;GO:0000790,cellular_component nuclear chromatin;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0010499,biological_process proteasomal ubiquitin-independent protein catabolic process;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016363,cellular_component nuclear matrix;GO:0016567,biological_process protein ubiquitination;GO:0017148,biological_process negative regulation of translation;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043025,cellular_component neuronal cell body	NA	ectodermal-neural cortex 1 [Source:HGNC Symbol%3BAcc:HGNC:3345]
ENSG00000162734	291.08	300.62	288.07	310.89	285.96	294.78	-0.00829358469149486	7.06563641951001	0.904593895565397	0.986670073549915	1:160205336-160215376:+	PEA15	16;GO:0000077,biological_process DNA damage checkpoint;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005875,cellular_component microtubule associated complex;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0008643,biological_process carbohydrate transport;GO:0042981,biological_process regulation of apoptotic process;GO:0043278,biological_process response to morphine;GO:0046325,biological_process negative regulation of glucose import;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902043,biological_process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	NA	phosphoprotein enriched in astrocytes 15 [Source:HGNC Symbol%3BAcc:HGNC:8822]
ENSG00000196275	4.56	3.85	5.42	4.66	4.92	4.23	0.0240209503072404	3.89222234603213	0.904708397673179	0.986670073549915	7:74796143-74851551:-	GTF2IRD2	11;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development	NA	GTF2I repeat domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30775]
ENSG00000156162	27.28	27.50	28.33	27.09	29.16	28.03	-0.00813253896195791	5.97978001782514	0.90477648956389	0.986670073549915	8:94719702-94793836:+	DPY19L4	7;GO:0000030,molecular_function mannosyltransferase activity;GO:0005637,cellular_component nuclear inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018406,biological_process protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	NA	dpy-19 like 4 (C. elegans) [Source:HGNC Symbol%3BAcc:HGNC:27829]
ENSG00000152292	6.26	5.57	7.89	6.98	7.07	6.56	-0.0367504888049128	1.6094731817269	0.90485617664654	0.986670073549915	2:85418720-85437029:+	SH2D6	7;GO:0005068,molecular_function transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005737,cellular_component cytoplasm;GO:0006955,biological_process immune response;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009967,biological_process positive regulation of signal transduction;GO:0035556,biological_process intracellular signal transduction	NA	SH2 domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:30439]
ENSG00000127080	3.36	3.76	4.10	3.05	3.76	4.25	0.0274430425131841	2.49153874846874	0.904889914003641	0.986670073549915	9:92613183-92670265:-	IPPK	14;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032958,biological_process inositol phosphate biosynthetic process;GO:0035299,molecular_function inositol pentakisphosphate 2-kinase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0052746,biological_process inositol phosphorylation	IPPK; inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]; K10572	inositol-pentakisphosphate 2-kinase [Source:HGNC Symbol%3BAcc:HGNC:14645]
ENSG00000138081	30.85	29.18	29.30	30.85	30.75	29.00	-0.00749284366146586	6.42913470267839	0.905014708248917	0.986670073549915	2:47789315-47905793:-	FBXO11	18;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007605,biological_process sensory perception of sound;GO:0008270,molecular_function zinc ion binding;GO:0016274,molecular_function protein-arginine N-methyltransferase activity;GO:0016567,biological_process protein ubiquitination;GO:0035246,biological_process peptidyl-arginine N-methylation;GO:0043687,biological_process post-translational protein modification;GO:0046872,molecular_function metal ion binding	NA	F-box protein 11 [Source:HGNC Symbol%3BAcc:HGNC:13590]
ENSG00000122592	8.70	7.76	9.49	8.14	9.67	7.95	0.0337248320402184	2.61256817920828	0.905015495250756	0.986670073549915	7:27153715-27157936:-	HOXA7	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0001953,biological_process negative regulation of cell-matrix adhesion;GO:0002686,biological_process negative regulation of leukocyte migration;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0009952,biological_process anterior/posterior pattern specification;GO:0031965,cellular_component nuclear membrane;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045617,biological_process negative regulation of keratinocyte differentiation;GO:0045656,biological_process negative regulation of monocyte differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048863,biological_process stem cell differentiation	NA	homeobox A7 [Source:HGNC Symbol%3BAcc:HGNC:5108]
ENSG00000169926	7.09	4.69	6.04	5.98	6.75	5.77	-0.0211030773828186	2.46011367905996	0.905079392803558	0.986670073549915	15:31326854-31435665:+	KLF13	15;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008285,biological_process negative regulation of cell proliferation;GO:0045647,biological_process negative regulation of erythrocyte differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	Kruppel like factor 13 [Source:HGNC Symbol%3BAcc:HGNC:13672]
ENSG00000139908	4.43	5.21	5.57	5.39	5.46	4.16	0.0306788620010759	2.48313555594749	0.905079837360298	0.986670073549915	14:24205696-24208362:+	TSSK4	18;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0032793,biological_process positive regulation of CREB transcription factor activity;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	testis specific serine kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:19825]
ENSG00000215271	12.62	15.04	14.28	12.54	14.31	14.97	0.00975739634884969	4.57278559611296	0.90511658160903	0.986670073549915	14:23272421-23299447:-	HOMEZ	9;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated	NA	homeobox and leucine zipper encoding [Source:HGNC Symbol%3BAcc:HGNC:20164]
ENSG00000167468	230.85	233.94	232.43	233.59	232.04	233.89	0.00686122166125862	7.97035176643547	0.905273086096682	0.986694226952828	19:1103925-1106791:+	GPX4	19;GO:0004601,molecular_function peroxidase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006644,biological_process phospholipid metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0007275,biological_process multicellular organism development;GO:0016491,molecular_function oxidoreductase activity;GO:0019372,biological_process lipoxygenase pathway;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0047066,molecular_function phospholipid-hydroperoxide glutathione peroxidase activity;GO:0051258,biological_process protein polymerization;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	GPX4; phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]; K05361	glutathione peroxidase 4 [Source:HGNC Symbol%3BAcc:HGNC:4556]
ENSG00000134250	34.27	30.65	33.87	33.54	31.11	34.42	0.00854264298245156	7.99286675451253	0.905297716165774	0.986694226952828	1:119911552-120069626:-	NOTCH2	40;GO:0000139,cellular_component Golgi membrane;GO:0001709,biological_process cell fate determination;GO:0002315,biological_process marginal zone B cell differentiation;GO:0003184,biological_process pulmonary valve morphogenesis;GO:0004872,molecular_function receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0007050,biological_process cell cycle arrest;GO:0007219,biological_process Notch signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0019827,biological_process stem cell population maintenance;GO:0030097,biological_process hemopoiesis;GO:0030154,biological_process cell differentiation;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0038049,molecular_function transcription factor activity, ligand-activated RNA polymerase II transcription factor binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043235,cellular_component receptor complex;GO:0046579,biological_process positive regulation of Ras protein signal transduction;GO:0046849,biological_process bone remodeling;GO:0050793,biological_process regulation of developmental process;GO:0060413,biological_process atrial septum morphogenesis;GO:0061314,biological_process Notch signaling involved in heart development	NOTCH1; Notch 1; K02599	notch 2 [Source:HGNC Symbol%3BAcc:HGNC:7882]
ENSG00000165891	10.75	8.29	12.43	12.32	8.74	11.11	-0.014969390337369	4.89569766374808	0.905689633348034	0.987018342073506	12:77021246-77065580:-	E2F7	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001890,biological_process placenta development;GO:0002040,biological_process sprouting angiogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007049,biological_process cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016607,cellular_component nuclear speck;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0032466,biological_process negative regulation of cytokinesis;GO:0032877,biological_process positive regulation of DNA endoreduplication;GO:0042802,molecular_function identical protein binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0060707,biological_process trophoblast giant cell differentiation;GO:0060718,biological_process chorionic trophoblast cell differentiation;GO:0070365,biological_process hepatocyte differentiation;GO:0071930,biological_process negative regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle	NA	E2F transcription factor 7 [Source:HGNC Symbol%3BAcc:HGNC:23820]
ENSG00000197976	13.32	12.36	14.24	13.96	14.34	12.34	-0.00875099989423967	4.9417549836353	0.905754123464055	0.987018342073506	X:1591592-1602514:+	AKAP17A	14;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0007165,biological_process signal transduction;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0042113,biological_process B cell activation;GO:0043484,biological_process regulation of RNA splicing;GO:0051018,molecular_function protein kinase A binding	NA	A-kinase anchoring protein 17A [Source:HGNC Symbol%3BAcc:HGNC:18783]
ENSG00000145020	5.01	3.11	5.54	4.83	4.01	5.30	-0.019397491348155	2.72939355041243	0.905835176566878	0.987020018146476	3:49416774-49422753:-	AMT	10;GO:0004047,molecular_function aminomethyltransferase activity;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006546,biological_process glycine catabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0008483,molecular_function transaminase activity;GO:0016740,molecular_function transferase activity;GO:0019464,biological_process glycine decarboxylation via glycine cleavage system;GO:0032259,biological_process methylation	gcvT, AMT; aminomethyltransferase [EC:2.1.2.10]; K00605	aminomethyltransferase [Source:HGNC Symbol%3BAcc:HGNC:473]
ENSG00000158352	3.55	4.74	3.78	3.83	4.57	3.86	-0.0211151104418979	4.18808928697054	0.905931418576151	0.987038242674078	X:50591646-50814302:-	SHROOM4	17;GO:0001725,cellular_component stress fiber;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0007015,biological_process actin filament organization;GO:0007275,biological_process multicellular organism development;GO:0007420,biological_process brain development;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0009925,cellular_component basal plasma membrane;GO:0015629,cellular_component actin cytoskeleton;GO:0016324,cellular_component apical plasma membrane;GO:0016460,cellular_component myosin II complex;GO:0030036,biological_process actin cytoskeleton organization;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0031941,cellular_component filamentous actin;GO:0050890,biological_process cognition;GO:0051015,molecular_function actin filament binding	NA	shroom family member 4 [Source:HGNC Symbol%3BAcc:HGNC:29215]
ENSG00000106991	2.69	2.87	3.39	3.00	2.81	3.35	-0.0215089721099533	2.63036956489421	0.906181706192677	0.98706699760729	9:127815011-127854756:-	ENG	63;GO:0001300,biological_process chronological cell aging;GO:0001525,biological_process angiogenesis;GO:0001569,biological_process patterning of blood vessels;GO:0001570,biological_process vasculogenesis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001947,biological_process heart looping;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003198,biological_process epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003208,biological_process cardiac ventricle morphogenesis;GO:0003209,biological_process cardiac atrium morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003273,biological_process cell migration involved in endocardial cushion formation;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005072,molecular_function transforming growth factor beta receptor, cytoplasmic mediator activity;GO:0005114,molecular_function type II transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005534,molecular_function galactose binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005615,cellular_component extracellular space;GO:0005925,cellular_component focal adhesion;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007155,biological_process cell adhesion;GO:0007507,biological_process heart development;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0022009,biological_process central nervous system vasculogenesis;GO:0030336,biological_process negative regulation of cell migration;GO:0030509,biological_process BMP signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0031953,biological_process negative regulation of protein autophosphorylation;GO:0031960,biological_process response to corticosteroid;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0035912,biological_process dorsal aorta morphogenesis;GO:0036122,molecular_function BMP binding;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0043235,cellular_component receptor complex;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048185,molecular_function activin binding;GO:0048745,biological_process smooth muscle tissue development;GO:0048844,biological_process artery morphogenesis;GO:0048845,biological_process venous blood vessel morphogenesis;GO:0050431,molecular_function transforming growth factor beta binding;GO:0055009,biological_process atrial cardiac muscle tissue morphogenesis;GO:0060348,biological_process bone development;GO:0070022,cellular_component transforming growth factor beta receptor homodimeric complex;GO:0070278,biological_process extracellular matrix constituent secretion;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0071559,biological_process response to transforming growth factor beta;GO:0072563,cellular_component endothelial microparticle;GO:0097084,biological_process vascular smooth muscle cell development;GO:1905007,biological_process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:1905065,biological_process positive regulation of vascular smooth muscle cell differentiation;GO:1905222,biological_process atrioventricular canal morphogenesis	NA	endoglin [Source:HGNC Symbol%3BAcc:HGNC:3349]
ENSG00000153207	15.69	14.65	14.50	14.73	14.55	15.68	0.0082905427988796	6.69845437797268	0.906285047917857	0.98706699760729	1:246839097-246931978:-	AHCTF1	27;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000785,cellular_component chromatin;GO:0000910,biological_process cytokinesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006810,biological_process transport;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0015031,biological_process protein transport;GO:0016363,cellular_component nuclear matrix;GO:0031080,cellular_component nuclear pore outer ring;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0051028,biological_process mRNA transport;GO:0051292,biological_process nuclear pore complex assembly;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome	NA	AT-hook containing transcription factor 1 [Source:HGNC Symbol%3BAcc:HGNC:24618]
ENSG00000100722	31.04	29.23	32.43	31.07	30.37	32.61	-0.00748244916591953	6.45588929506116	0.906299938922853	0.98706699760729	14:88562908-88627596:+	ZC3H14	10;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0008143,molecular_function poly(A) binding;GO:0016607,cellular_component nuclear speck;GO:0043488,biological_process regulation of mRNA stability;GO:0046872,molecular_function metal ion binding;GO:1900364,biological_process negative regulation of mRNA polyadenylation	NA	zinc finger CCCH-type containing 14 [Source:HGNC Symbol%3BAcc:HGNC:20509]
ENSG00000169871	22.14	21.22	24.22	23.25	22.71	22.67	-0.00750172619308172	5.75205218900397	0.906326167819353	0.98706699760729	7:101085438-101097967:+	TRIM56	15;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016740,molecular_function transferase activity;GO:0032479,biological_process regulation of type I interferon production;GO:0032608,biological_process interferon-beta production;GO:0034340,biological_process response to type I interferon;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0070534,biological_process protein K63-linked ubiquitination	NA	tripartite motif containing 56 [Source:HGNC Symbol%3BAcc:HGNC:19028]
ENSG00000135119	0.76	1.25	1.58	1.42	1.40	0.67	0.0479917527942804	1.08215295604617	0.906507699065565	0.98706699760729	12:116738177-116853631:+	RNFT2	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	ring finger protein%2C transmembrane 2 [Source:HGNC Symbol%3BAcc:HGNC:25905]
ENSG00000273749	40.60	41.22	40.71	41.52	41.81	39.57	0.00730119185099025	7.42777662093394	0.906531868124184	0.98706699760729	15:22867051-22981063:-	CYFIP1	57;GO:0000340,molecular_function RNA 7-methylguanosine cap binding;GO:0001726,cellular_component ruffle;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005845,cellular_component mRNA cap binding complex;GO:0005925,cellular_component focal adhesion;GO:0006417,biological_process regulation of translation;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008360,biological_process regulation of cell shape;GO:0016601,biological_process Rac protein signal transduction;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0031175,biological_process neuron projection development;GO:0031209,cellular_component SCAR complex;GO:0031529,biological_process ruffle organization;GO:0032403,molecular_function protein complex binding;GO:0032433,cellular_component filopodium tip;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034774,cellular_component secretory granule lumen;GO:0035580,cellular_component specific granule lumen;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043195,cellular_component terminal bouton;GO:0043197,cellular_component dendritic spine;GO:0043312,biological_process neutrophil degranulation;GO:0044294,cellular_component dendritic growth cone;GO:0044295,cellular_component axonal growth cone;GO:0045202,cellular_component synapse;GO:0045773,biological_process positive regulation of axon extension;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048365,molecular_function Rac GTPase binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048675,biological_process axon extension;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050890,biological_process cognition;GO:0051015,molecular_function actin filament binding;GO:0051388,biological_process positive regulation of neurotrophin TRK receptor signaling pathway;GO:0051602,biological_process response to electrical stimulus;GO:0060076,cellular_component excitatory synapse;GO:0070062,cellular_component extracellular exosome;GO:0090724,cellular_component central region of growth cone;GO:0090725,cellular_component peripheral region of growth cone;GO:0097484,biological_process dendrite extension;GO:0099563,biological_process modification of synaptic structure;GO:1900006,biological_process positive regulation of dendrite development;GO:1900029,biological_process positive regulation of ruffle assembly;GO:1903422,biological_process negative regulation of synaptic vesicle recycling;GO:1904724,cellular_component tertiary granule lumen;GO:2000601,biological_process positive regulation of Arp2/3 complex-mediated actin nucleation	CYFIP; cytoplasmic FMR1 interacting protein; K05749	cytoplasmic FMR1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:13759]
ENSG00000125977	327.11	300.47	319.45	319.95	314.15	325.62	-0.00686173605467802	8.3123393123535	0.906536447705784	0.98706699760729	20:34088297-34112332:-	EIF2S2	14;GO:0001701,biological_process in utero embryonic development;GO:0002176,biological_process male germ cell proliferation;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005850,cellular_component eukaryotic translation initiation factor 2 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0008584,biological_process male gonad development;GO:0046872,molecular_function metal ion binding;GO:0055085,biological_process transmembrane transport	EIF2S2; translation initiation factor 2 subunit 2; K03238	eukaryotic translation initiation factor 2 subunit beta [Source:HGNC Symbol%3BAcc:HGNC:3266]
ENSG00000131375	18.75	14.84	17.06	16.94	17.07	17.54	-0.0074627532420422	5.41752019427173	0.906755212045937	0.98706699760729	3:15206151-15252918:+	CAPN7	17;GO:0004175,molecular_function endopeptidase activity;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome;GO:0090541,molecular_function MIT domain binding;GO:0097264,biological_process self proteolysis	NA	calpain 7 [Source:HGNC Symbol%3BAcc:HGNC:1484]
ENSG00000133958	0.09	0.13	0.06	0.09	0.06	0.14	-0.0761137824377344	-0.132590949211837	0.90681937410257	0.98706699760729	14:93333218-93707876:+	UNC79	7;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030534,biological_process adult behavior;GO:0034220,biological_process ion transmembrane transport;GO:0035264,biological_process multicellular organism growth;GO:0048149,biological_process behavioral response to ethanol	NA	unc-79 homolog%2C NALCN channel complex subunit [Source:HGNC Symbol%3BAcc:HGNC:19966]
ENSG00000134444	9.29	10.99	9.73	9.01	10.03	10.93	0.00819083382689213	5.30057803561503	0.90702821252477	0.98706699760729	18:62187257-62307829:+	KIAA1468	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	KIAA1468 [Source:HGNC Symbol%3BAcc:HGNC:29289]
ENSG00000138604	5.95	6.04	6.36	5.99	6.11	6.61	-0.0160626752503266	3.53595460210368	0.907035327263381	0.98706699760729	15:69160583-69272217:+	GLCE	11;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016853,molecular_function isomerase activity;GO:0016857,molecular_function racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0030210,biological_process heparin biosynthetic process;GO:0047464,molecular_function heparosan-N-sulfate-glucuronate 5-epimerase activity;GO:0050379,molecular_function UDP-glucuronate 5'-epimerase activity	GLCE; heparosan-N-sulfate-glucuronate 5-epimerase [EC:5.1.3.17]; K01793	glucuronic acid epimerase [Source:HGNC Symbol%3BAcc:HGNC:17855]
ENSG00000163719	18.19	19.21	17.97	18.55	19.67	17.91	-0.0104103297693413	5.33141738375558	0.907092773047789	0.98706699760729	3:9649432-9702393:+	MTMR14	15;GO:0001726,cellular_component ruffle;GO:0004438,molecular_function phosphatidylinositol-3-phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0016236,biological_process macroautophagy;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0052629,molecular_function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	NA	myotubularin related protein 14 [Source:HGNC Symbol%3BAcc:HGNC:26190]
ENSG00000198252	22.49	17.43	21.67	21.60	20.18	21.23	-0.0093624754636103	3.81939481400293	0.907119701180932	0.98706699760729	14:52730179-52774998:+	STYX	14;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0007283,biological_process spermatogenesis;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0045204,biological_process MAPK export from nucleus;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade	NA	serine/threonine/tyrosine interacting protein [Source:HGNC Symbol%3BAcc:HGNC:11447]
ENSG00000111652	62.42	60.16	62.00	64.91	61.12	61.17	-0.00733921473687043	5.97965035656122	0.907149834902275	0.98706699760729	12:6723740-6731875:+	COPS7A	10;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0008180,cellular_component COP9 signalosome;GO:0043687,biological_process post-translational protein modification	NA	COP9 signalosome subunit 7A [Source:HGNC Symbol%3BAcc:HGNC:16758]
ENSG00000138757	78.98	79.04	77.62	77.77	79.25	79.31	0.00726504608215625	6.83245759000017	0.907150592822361	0.98706699760729	4:75642781-75724525:-	G3BP2	14;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0007253,biological_process cytoplasmic sequestering of NF-kappaB;GO:0007265,biological_process Ras protein signal transduction;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0034063,biological_process stress granule assembly;GO:0051028,biological_process mRNA transport	NA	G3BP stress granule assembly factor 2 [Source:HGNC Symbol%3BAcc:HGNC:30291]
ENSG00000087448	4.07	4.35	4.34	4.60	3.89	4.55	-0.0246762895448874	2.77944315425507	0.907311857325147	0.987144396975594	12:27780019-27803040:+	KLHL42	14;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0032886,biological_process regulation of microtubule-based process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0051301,biological_process cell division	NA	kelch like family member 42 [Source:HGNC Symbol%3BAcc:HGNC:29252]
ENSG00000186318	14.51	14.77	13.98	15.14	14.02	14.08	0.0107026027995861	4.49421591903318	0.907380775758602	0.987144396975594	11:117285206-117316259:-	BACE1	32;GO:0001540,molecular_function beta-amyloid binding;GO:0004175,molecular_function endopeptidase activity;GO:0004190,molecular_function aspartic-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006508,biological_process proteolysis;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008798,molecular_function beta-aspartyl-peptidase activity;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0030163,biological_process protein catabolic process;GO:0030424,cellular_component axon;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0044267,biological_process cellular protein metabolic process;GO:0045121,cellular_component membrane raft;GO:0050435,biological_process beta-amyloid metabolic process;GO:0050804,biological_process modulation of synaptic transmission;GO:0070931,cellular_component Golgi-associated vesicle lumen	BACE1; beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46]; K04521	beta-secretase 1 [Source:HGNC Symbol%3BAcc:HGNC:933]
ENSG00000091317	52.49	56.75	49.07	50.46	59.26	50.98	-0.0135200050383191	4.87314492153689	0.907589021972337	0.987284421149997	3:32481311-32503408:-	CMTM6	10;GO:0005125,molecular_function cytokine activity;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006935,biological_process chemotaxis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035577,cellular_component azurophil granule membrane;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	CKLF like MARVEL transmembrane domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:19177]
ENSG00000125149	14.26	15.45	13.02	14.55	13.58	14.49	0.00880626675961692	4.36631595097692	0.90782311264609	0.987433830429371	16:67109957-67148539:+	C16orf70	1;GO:0005515,molecular_function protein binding	NA	chromosome 16 open reading frame 70 [Source:HGNC Symbol%3BAcc:HGNC:29564]
ENSG00000126561	0.30	0.32	0.43	0.22	0.32	0.44	0.104760842614298	-0.0550730840032477	0.907885467388255	0.987433830429371	17:42287546-42311943:+	STAT5A	32;GO:0000255,biological_process allantoin metabolic process;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006101,biological_process citrate metabolic process;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0006105,biological_process succinate metabolic process;GO:0006107,biological_process oxaloacetate metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006549,biological_process isoleucine metabolic process;GO:0006573,biological_process valine metabolic process;GO:0006600,biological_process creatine metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0007165,biological_process signal transduction;GO:0007259,biological_process JAK-STAT cascade;GO:0007595,biological_process lactation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019530,biological_process taurine metabolic process;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0040014,biological_process regulation of multicellular organism growth;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0046449,biological_process creatinine metabolic process;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway	STAT5A; signal transducer and activator of transcription 5A; K11223	signal transducer and activator of transcription 5A [Source:HGNC Symbol%3BAcc:HGNC:11366]
ENSG00000169246	2.48	2.90	2.55	2.85	2.92	2.35	-0.0285220615170604	2.67329797488019	0.908002727375115	0.987474842728869	16:21402236-21448567:-	NPIPB3	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	nuclear pore complex interacting protein family member B3 [Source:HGNC Symbol%3BAcc:HGNC:28989]
ENSG00000196655	61.55	66.15	62.49	64.28	64.75	61.45	0.00726003599407171	5.75339155569466	0.908215124238632	0.987619302424366	11:119018431-119025454:+	TRAPPC4	18;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0008021,cellular_component synaptic vesicle;GO:0016192,biological_process vesicle-mediated transport;GO:0016358,biological_process dendrite development;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0030425,cellular_component dendrite;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 4 [Source:HGNC Symbol%3BAcc:HGNC:19943]
ENSG00000129480	8.04	8.16	10.60	10.03	9.91	7.66	-0.0213624499132086	2.4786448090622	0.908301664748633	0.98762688897379	14:31446035-31457510:-	DTD2	11;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0006399,biological_process tRNA metabolic process;GO:0006450,biological_process regulation of translational fidelity;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0051499,molecular_function D-aminoacyl-tRNA deacylase activity;GO:0051500,molecular_function D-tyrosyl-tRNA(Tyr) deacylase activity	NA	D-tyrosyl-tRNA deacylase 2 (putative) [Source:HGNC Symbol%3BAcc:HGNC:20277]
ENSG00000181924	139.78	145.34	133.66	137.53	152.21	135.02	-0.0104243721613935	5.34451938220746	0.908486546894879	0.987741394990465	11:73872666-73876988:-	COA4	3;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	cytochrome c oxidase assembly factor 4 homolog [Source:HGNC Symbol%3BAcc:HGNC:24604]
ENSG00000156239	9.02	10.42	10.32	10.85	8.86	10.73	-0.028810032192702	2.720000341816	0.908578366092015	0.987754708206357	21:28872190-28885371:-	N6AMT1	13;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006415,biological_process translational termination;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030307,biological_process positive regulation of cell growth;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex	NA	N-6 adenine-specific DNA methyltransferase 1 (putative) [Source:HGNC Symbol%3BAcc:HGNC:16021]
ENSG00000169635	1.42	1.76	1.60	1.30	1.40	1.94	0.0349331139552193	1.60436579304338	0.908788803911345	0.987896963214951	22:21417403-21451463:+	HIC2	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008022,molecular_function protein C-terminus binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	HIC ZBTB transcriptional repressor 2 [Source:HGNC Symbol%3BAcc:HGNC:18595]
ENSG00000158710	631.35	662.73	642.34	640.50	686.03	615.60	0.00730296026974118	8.7382973199862	0.908904683267574	0.987936412732084	1:159918106-159925732:-	TAGLN2	8;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0030855,biological_process epithelial cell differentiation;GO:0031982,cellular_component vesicle;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome	NA	transgelin 2 [Source:HGNC Symbol%3BAcc:HGNC:11554]
ENSG00000140307	115.43	124.44	118.74	123.50	120.06	115.36	0.00784680232193708	5.31190963261089	0.909003163393106	0.987956944855847	15:59638061-59657541:-	GTF2A2	22;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005672,cellular_component transcription factor TFIIA complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0016032,biological_process viral process;GO:0017025,molecular_function TBP-class protein binding;GO:0030054,cellular_component cell junction;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly	TFIIA2, GTF2A2, TOA2; transcription initiation factor TFIIA small subunit; K03123	general transcription factor IIA subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:4647]
ENSG00000154930	1.62	1.80	1.82	2.02	1.06	2.34	-0.0418512752895408	2.04085195939528	0.909095899684457	0.987971231201468	20:25006229-25058980:-	ACSS1	15;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003987,molecular_function acetate-CoA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006069,biological_process ethanol oxidation;GO:0006085,biological_process acetyl-CoA biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016208,molecular_function AMP binding;GO:0016874,molecular_function ligase activity;GO:0019413,biological_process acetate biosynthetic process;GO:0019427,biological_process acetyl-CoA biosynthetic process from acetate;GO:0019542,biological_process propionate biosynthetic process	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]; K01895	acyl-CoA synthetase short chain family member 1 [Source:HGNC Symbol%3BAcc:HGNC:16091]
ENSG00000204348	19.52	16.07	22.31	18.08	19.51	20.38	0.0178538970588721	4.551480781033	0.909182648133474	0.987979008253595	6:31969809-31972292:-	DXO	18;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006402,biological_process mRNA catabolic process;GO:0008152,biological_process metabolic process;GO:0008409,molecular_function 5'-3' exonuclease activity;GO:0016787,molecular_function hydrolase activity;GO:0034353,molecular_function RNA pyrophosphohydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0050779,biological_process RNA destabilization;GO:0071028,biological_process nuclear mRNA surveillance;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	decapping exoribonuclease [Source:HGNC Symbol%3BAcc:HGNC:2992]
ENSG00000084070	12.68	11.52	12.45	12.25	12.46	12.04	0.0139281192198818	4.15661353887927	0.909276217174956	0.987994195009868	1:40344849-40423326:+	SMAP2	5;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding	SMAP; stromal membrane-associated protein; K12486	small ArfGAP2 [Source:HGNC Symbol%3BAcc:HGNC:25082]
ENSG00000150455	3.52	3.22	3.58	2.61	3.50	4.56	-0.0365433724432747	1.57279872724533	0.90964935266089	0.988127696386371	11:126283064-126298845:+	TIRAP	49;GO:0002376,biological_process immune system process;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0005080,molecular_function protein kinase C binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0016020,cellular_component membrane;GO:0030099,biological_process myeloid cell differentiation;GO:0030139,cellular_component endocytic vesicle;GO:0030674,molecular_function protein binding, bridging;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0032496,biological_process response to lipopolysaccharide;GO:0032587,cellular_component ruffle membrane;GO:0032648,biological_process regulation of interferon-beta production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0032738,biological_process positive regulation of interleukin-15 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0034137,biological_process positive regulation of toll-like receptor 2 signaling pathway;GO:0034141,biological_process positive regulation of toll-like receptor 3 signaling pathway;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0034145,biological_process positive regulation of toll-like receptor 4 signaling pathway;GO:0035662,molecular_function Toll-like receptor 4 binding;GO:0035663,molecular_function Toll-like receptor 2 binding;GO:0035665,biological_process TIRAP-dependent toll-like receptor 4 signaling pathway;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044130,biological_process negative regulation of growth of symbiont in host;GO:0045087,biological_process innate immune response;GO:0045088,biological_process regulation of innate immune response;GO:0045410,biological_process positive regulation of interleukin-6 biosynthetic process;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046982,molecular_function protein heterodimerization activity;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070935,biological_process 3'-UTR-mediated mRNA stabilization;GO:0071221,biological_process cellular response to bacterial lipopeptide;GO:0071223,biological_process cellular response to lipoteichoic acid;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:0090073,biological_process positive regulation of protein homodimerization activity;GO:2000340,biological_process positive regulation of chemokine (C-X-C motif) ligand 1 production;GO:2000343,biological_process positive regulation of chemokine (C-X-C motif) ligand 2 production	TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; K05403	TIR domain containing adaptor protein [Source:HGNC Symbol%3BAcc:HGNC:17192]
ENSG00000171747	0.61	1.11	0.71	1.08	0.73	0.48	0.0639768206093351	-0.0730146146006814	0.909677249643272	0.988127696386371	19:38801670-38813364:-	LGALS4	6;GO:0005615,cellular_component extracellular space;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0016936,molecular_function galactoside binding;GO:0030246,molecular_function carbohydrate binding	NA	galectin 4 [Source:HGNC Symbol%3BAcc:HGNC:6565]
ENSG00000196782	0.99	0.64	0.68	0.63	0.91	0.73	0.0564425938830849	1.53548982506777	0.909729730134855	0.988127696386371	4:139716752-140154184:-	MAML3	10;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0007219,biological_process Notch signaling pathway;GO:0007221,biological_process positive regulation of transcription of Notch receptor target;GO:0016607,cellular_component nuclear speck;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	MAML; mastermind; K06061	mastermind like transcriptional coactivator 3 [Source:HGNC Symbol%3BAcc:HGNC:16272]
ENSG00000136997	59.05	59.11	59.81	62.34	58.36	59.64	-0.00726864287954512	7.0739507730486	0.909773572903691	0.988127696386371	8:127735433-127741434:+	MYC	73;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006112,biological_process energy reserve metabolic process;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007050,biological_process cell cycle arrest;GO:0007219,biological_process Notch signaling pathway;GO:0008134,molecular_function transcription factor binding;GO:0008150,biological_process biological_process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010332,biological_process response to gamma radiation;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0015671,biological_process oxygen transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016579,biological_process protein deubiquitination;GO:0032204,biological_process regulation of telomere maintenance;GO:0032403,molecular_function protein complex binding;GO:0032873,biological_process negative regulation of stress-activated MAPK cascade;GO:0032986,biological_process protein-DNA complex disassembly;GO:0033613,molecular_function activating transcription factor binding;GO:0034644,biological_process cellular response to UV;GO:0035690,biological_process cellular response to drug;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044195,cellular_component nucleoplasmic reticulum;GO:0044346,biological_process fibroblast apoptotic process;GO:0045656,biological_process negative regulation of monocyte differentiation;GO:0045727,biological_process positive regulation of translation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0051276,biological_process chromosome organization;GO:0051782,biological_process negative regulation of cell division;GO:0051973,biological_process positive regulation of telomerase activity;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070491,molecular_function repressing transcription factor binding;GO:0070848,biological_process response to growth factor;GO:0070888,molecular_function E-box binding;GO:0071074,molecular_function eukaryotic initiation factor eIF2 binding;GO:0071456,biological_process cellular response to hypoxia;GO:0090096,biological_process positive regulation of metanephric cap mesenchymal cell proliferation;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:2000573,biological_process positive regulation of DNA biosynthetic process;GO:2001022,biological_process positive regulation of response to DNA damage stimulus	MYC; Myc proto-oncogene protein; K04377	MYC proto-oncogene%2C bHLH transcription factor [Source:HGNC Symbol%3BAcc:HGNC:7553]
ENSG00000162129	5.42	4.84	4.57	5.72	5.15	3.90	0.0224070026445347	3.49399207234654	0.909797103198246	0.988127696386371	11:72292424-72434680:-	CLPB	9;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0034605,biological_process cellular response to heat	clpB; ATP-dependent Clp protease ATP-binding subunit ClpB; K03695	ClpB homolog%2C mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol%3BAcc:HGNC:30664]
ENSG00000101596	14.06	13.83	14.65	13.92	14.00	15.21	-0.00773873850228535	6.44093091414308	0.909989341125039	0.988250016744104	18:2655737-2805017:+	SMCHD1	9;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001740,cellular_component Barr body;GO:0005524,molecular_function ATP binding;GO:0005694,cellular_component chromosome;GO:0009048,biological_process dosage compensation by inactivation of X chromosome;GO:0016887,molecular_function ATPase activity;GO:0043584,biological_process nose development;GO:0051276,biological_process chromosome organization;GO:0060821,biological_process inactivation of X chromosome by DNA methylation	NA	structural maintenance of chromosomes flexible hinge domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:29090]
ENSG00000047346	5.75	6.07	6.08	5.58	6.70	5.62	0.011615709087075	4.33256396960406	0.910208885057507	0.988401967476059	15:52581316-52709817:-	FAM214A	1;GO:0005515,molecular_function protein binding	NA	family with sequence similarity 214 member A [Source:HGNC Symbol%3BAcc:HGNC:25609]
ENSG00000064545	15.29	15.42	15.99	16.27	14.65	16.54	-0.0116746488712506	4.51919673671535	0.910508521464299	0.988453033724879	19:19119168-19138513:-	TMEM161A	7;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032526,biological_process response to retinoic acid;GO:0034599,biological_process cellular response to oxidative stress;GO:0034644,biological_process cellular response to UV;GO:0045739,biological_process positive regulation of DNA repair;GO:1902230,biological_process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	NA	transmembrane protein 161A [Source:HGNC Symbol%3BAcc:HGNC:26020]
ENSG00000148396	16.07	18.53	15.73	16.77	18.04	15.59	0.00846170921270724	6.97122330684759	0.910573997017596	0.988453033724879	9:136440095-136483759:-	SEC16A	13;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0007029,biological_process endoplasmic reticulum organization;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0021762,biological_process substantia nigra development;GO:0048208,biological_process COPII vesicle coating	NA	SEC16 homolog A%2C endoplasmic reticulum export factor [Source:HGNC Symbol%3BAcc:HGNC:29006]
ENSG00000180957	58.24	55.84	53.95	58.89	58.64	52.95	-0.00811977077850663	5.66322234921277	0.910628483753511	0.988453033724879	22:27851668-27920134:-	PITPNB	12;GO:0000139,cellular_component Golgi membrane;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006997,biological_process nucleus organization;GO:0008289,molecular_function lipid binding;GO:0015914,biological_process phospholipid transport;GO:0070062,cellular_component extracellular exosome	NA	phosphatidylinositol transfer protein beta [Source:HGNC Symbol%3BAcc:HGNC:9002]
ENSG00000180287	3.77	2.85	2.88	2.51	3.72	3.58	-0.0266116546295036	2.42361720008341	0.910733921501768	0.988453033724879	1:242082985-242524696:-	PLD5	3;GO:0003824,molecular_function catalytic activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	phospholipase D family member 5 [Source:HGNC Symbol%3BAcc:HGNC:26879]
ENSG00000176909	0.35	0.48	0.84	0.70	0.38	0.76	-0.115068181902271	-0.0362975307876231	0.91074683993554	0.988453033724879	19:48712741-48719721:-	MAMSTR	6;GO:0001076,molecular_function transcription factor activity, RNA polymerase II transcription factor binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010831,biological_process positive regulation of myotube differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	MEF2 activating motif and SAP domain containing transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:26689]
ENSG00000135441	5.69	6.62	3.58	5.61	4.97	4.87	0.032677656880606	1.54405171197445	0.910874568733902	0.988453033724879	12:55716036-55720087:+	BLOC1S1	23;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0008089,biological_process anterograde axonal transport;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0018394,biological_process peptidyl-lysine acetylation;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0032418,biological_process lysosome localization;GO:0032438,biological_process melanosome organization;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0060155,biological_process platelet dense granule organization;GO:0070062,cellular_component extracellular exosome;GO:0099078,cellular_component BORC complex;GO:1904115,cellular_component axon cytoplasm	NA	biogenesis of lysosomal organelles complex 1 subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4200]
ENSG00000167945	0.94	0.55	0.61	0.56	0.50	0.99	0.0589539730314971	0.000262788300806772	0.910878569039537	0.988453033724879	16:805442-813861:+	PRR25	NA	NA	proline rich 25 [Source:HGNC Symbol%3BAcc:HGNC:37230]
ENSG00000143612	150.70	152.66	168.00	157.34	159.91	155.56	0.00792703013747027	7.09480049588664	0.910892955190437	0.988453033724879	1:154206705-154220637:-	C1orf43	4;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	chromosome 1 open reading frame 43 [Source:HGNC Symbol%3BAcc:HGNC:29876]
ENSG00000109111	37.77	36.34	39.05	38.57	37.08	37.92	0.00731063240369352	7.6284307132419	0.911099608276687	0.98851518820593	17:28662090-28702684:+	SUPT6H	35;GO:0000991,molecular_function transcription factor activity, core RNA polymerase II binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006338,biological_process chromatin remodeling;GO:0006342,biological_process chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006397,biological_process mRNA processing;GO:0006810,biological_process transport;GO:0008023,cellular_component transcription elongation factor complex;GO:0008380,biological_process RNA splicing;GO:0010793,biological_process regulation of mRNA export from nucleus;GO:0016032,biological_process viral process;GO:0031491,molecular_function nucleosome binding;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0034728,biological_process nucleosome organization;GO:0035327,cellular_component transcriptionally active chromatin;GO:0042393,molecular_function histone binding;GO:0042789,biological_process mRNA transcription from RNA polymerase II promoter;GO:0045191,biological_process regulation of isotype switching;GO:0050684,biological_process regulation of mRNA processing;GO:0051028,biological_process mRNA transport;GO:0051147,biological_process regulation of muscle cell differentiation;GO:0061086,biological_process negative regulation of histone H3-K27 methylation;GO:0070827,biological_process chromatin maintenance	NA	SPT6 homolog%2C histone chaperone [Source:HGNC Symbol%3BAcc:HGNC:11470]
ENSG00000116299	0.92	0.65	1.15	0.80	1.04	1.01	-0.0298733913050985	1.60258758048623	0.911217998698617	0.98851518820593	1:109113678-109206781:+	KIAA1324	18;GO:0000045,biological_process autophagosome assembly;GO:0003723,molecular_function RNA binding;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006914,biological_process autophagy;GO:0009267,biological_process cellular response to starvation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031902,cellular_component late endosome membrane;GO:0044090,biological_process positive regulation of vacuole organization;GO:0070062,cellular_component extracellular exosome;GO:2000786,biological_process positive regulation of autophagosome assembly	NA	KIAA1324 [Source:HGNC Symbol%3BAcc:HGNC:29618]
ENSG00000168394	46.36	41.32	42.08	46.95	37.83	46.97	-0.0095236249484388	6.72692118428711	0.911248294934823	0.98851518820593	6:32845208-32853978:-	TAP1	38;GO:0000166,molecular_function nucleotide binding;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005815,cellular_component microtubule organizing center;GO:0006810,biological_process transport;GO:0006952,biological_process defense response;GO:0015031,biological_process protein transport;GO:0015197,molecular_function peptide transporter activity;GO:0015440,molecular_function peptide-transporting ATPase activity;GO:0015833,biological_process peptide transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016887,molecular_function ATPase activity;GO:0019885,biological_process antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0023029,molecular_function MHC class Ib protein binding;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042287,molecular_function MHC protein binding;GO:0042288,molecular_function MHC class I protein binding;GO:0042605,molecular_function peptide antigen binding;GO:0042626,molecular_function ATPase activity, coupled to transmembrane movement of substances;GO:0042803,molecular_function protein homodimerization activity;GO:0042825,cellular_component TAP complex;GO:0043531,molecular_function ADP binding;GO:0046967,biological_process cytosol to ER transport;GO:0046978,molecular_function TAP1 binding;GO:0046979,molecular_function TAP2 binding;GO:0055085,biological_process transmembrane transport;GO:1990668,biological_process vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2; K05653	transporter 1%2C ATP binding cassette subfamily B member [Source:HGNC Symbol%3BAcc:HGNC:43]
ENSG00000118894	8.48	5.27	7.99	7.53	7.62	7.26	-0.0125644092816693	3.08796825915818	0.911403054939555	0.98851518820593	16:5084303-5097808:-	EEF2KMT	10;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006479,biological_process protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018023,biological_process peptidyl-lysine trimethylation;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex	NA	eukaryotic elongation factor 2 lysine methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:32221]
ENSG00000101346	23.87	28.42	25.37	25.25	27.34	26.11	-0.013876581789427	4.97632988214064	0.911455193619333	0.98851518820593	20:32207879-32238667:+	POFUT1	20;GO:0001525,biological_process angiogenesis;GO:0001756,biological_process somitogenesis;GO:0005783,cellular_component endoplasmic reticulum;GO:0005975,biological_process carbohydrate metabolic process;GO:0006004,biological_process fucose metabolic process;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0007219,biological_process Notch signaling pathway;GO:0007399,biological_process nervous system development;GO:0007507,biological_process heart development;GO:0008417,molecular_function fucosyltransferase activity;GO:0008593,biological_process regulation of Notch signaling pathway;GO:0009790,biological_process embryo development;GO:0016020,cellular_component membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0036066,biological_process protein O-linked fucosylation;GO:0046922,molecular_function peptide-O-fucosyltransferase activity	POFUT; peptide-O-fucosyltransferase [EC:2.4.1.221]; K03691	protein O-fucosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:14988]
ENSG00000142082	16.93	15.36	17.80	16.84	17.34	16.85	-0.00861836535306318	4.52740787268325	0.911522114421322	0.98851518820593	11:215457-236931:-	SIRT3	21;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006471,biological_process protein ADP-ribosylation;GO:0006476,biological_process protein deacetylation;GO:0007005,biological_process mitochondrion organization;GO:0007568,biological_process aging;GO:0008270,molecular_function zinc ion binding;GO:0009060,biological_process aerobic respiration;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0017136,molecular_function NAD-dependent histone deacetylase activity;GO:0019899,molecular_function enzyme binding;GO:0032024,biological_process positive regulation of insulin secretion;GO:0034979,molecular_function NAD-dependent protein deacetylase activity;GO:0034983,biological_process peptidyl-lysine deacetylation;GO:0046872,molecular_function metal ion binding;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070403,molecular_function NAD+ binding;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process	SIRT3, SIR2L3; NAD+-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]; K11413	sirtuin 3 [Source:HGNC Symbol%3BAcc:HGNC:14931]
ENSG00000196262	3266.77	3430.82	2964.50	3132.54	3529.77	3134.25	-0.00826365201256204	10.9296806943479	0.911532391431962	0.98851518820593	7:44796679-44824564:+	PPIA	36;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006278,biological_process RNA-dependent DNA biosynthetic process;GO:0006457,biological_process protein folding;GO:0016018,molecular_function cyclosporin A binding;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016853,molecular_function isomerase activity;GO:0019058,biological_process viral life cycle;GO:0019061,biological_process uncoating of virus;GO:0019064,biological_process fusion of virus membrane with host plasma membrane;GO:0019068,biological_process virion assembly;GO:0019076,biological_process viral release from host cell;GO:0030260,biological_process entry into host cell;GO:0031982,cellular_component vesicle;GO:0034389,biological_process lipid particle organization;GO:0034774,cellular_component secretory granule lumen;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0043312,biological_process neutrophil degranulation;GO:0045069,biological_process regulation of viral genome replication;GO:0045070,biological_process positive regulation of viral genome replication;GO:0046790,molecular_function virion binding;GO:0050714,biological_process positive regulation of protein secretion;GO:0050900,biological_process leukocyte migration;GO:0051082,molecular_function unfolded protein binding;GO:0070062,cellular_component extracellular exosome;GO:0075713,biological_process establishment of integrated proviral latency;GO:1904813,cellular_component ficolin-1-rich granule lumen	PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]; K03767	peptidylprolyl isomerase A [Source:HGNC Symbol%3BAcc:HGNC:9253]
ENSG00000240694	28.78	23.63	28.44	25.71	25.63	29.69	0.0143973222307915	4.89334890154497	0.91159967787944	0.98851518820593	8:26504685-26514092:-	PNMA2	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0043065,biological_process positive regulation of apoptotic process	NA	paraneoplastic Ma antigen 2 [Source:HGNC Symbol%3BAcc:HGNC:9159]
ENSG00000152556	37.66	38.27	34.15	36.72	39.00	34.59	0.00801591406073705	6.7591198835471	0.91174407672209	0.98851518820593	12:48105138-48146404:+	PFKM	33;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003872,molecular_function 6-phosphofructokinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005945,cellular_component 6-phosphofructokinase complex;GO:0005980,biological_process glycogen catabolic process;GO:0006002,biological_process fructose 6-phosphate metabolic process;GO:0006096,biological_process glycolytic process;GO:0008022,molecular_function protein C-terminus binding;GO:0008152,biological_process metabolic process;GO:0008443,molecular_function phosphofructokinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0019900,molecular_function kinase binding;GO:0032024,biological_process positive regulation of insulin secretion;GO:0042593,biological_process glucose homeostasis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046835,biological_process carbohydrate phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051259,biological_process protein oligomerization;GO:0061615,biological_process glycolytic process through fructose-6-phosphate;GO:0061621,biological_process canonical glycolysis;GO:0070061,molecular_function fructose binding;GO:0070062,cellular_component extracellular exosome;GO:0093001,biological_process glycolysis from storage polysaccharide through glucose-1-phosphate;GO:0097228,cellular_component sperm principal piece	NA	phosphofructokinase%2C muscle [Source:HGNC Symbol%3BAcc:HGNC:8877]
ENSG00000118579	58.36	55.56	48.30	52.70	57.12	52.45	0.0108032407411828	4.8941290657056	0.911746587430089	0.98851518820593	4:17614630-17634105:+	MED28	13;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0051151,biological_process negative regulation of smooth muscle cell differentiation	NA	mediator complex subunit 28 [Source:HGNC Symbol%3BAcc:HGNC:24628]
ENSG00000113161	34.73	38.99	31.36	32.10	37.58	35.48	0.00858504072461086	6.54612827393927	0.912008490206851	0.988638066888315	5:75336328-75362104:+	HMGCR	46;GO:0004420,molecular_function hydroxymethylglutaryl-CoA reductase (NADPH) activity;GO:0005515,molecular_function protein binding;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0006743,biological_process ubiquinone metabolic process;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008299,biological_process isoprenoid biosynthetic process;GO:0008542,biological_process visual learning;GO:0010664,biological_process negative regulation of striated muscle cell apoptotic process;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0015936,biological_process coenzyme A metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016616,molecular_function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019216,biological_process regulation of lipid metabolic process;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0042282,molecular_function hydroxymethylglutaryl-CoA reductase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0045445,biological_process myoblast differentiation;GO:0045471,biological_process response to ethanol;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0048643,biological_process positive regulation of skeletal muscle tissue development;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050661,molecular_function NADP binding;GO:0050662,molecular_function coenzyme binding;GO:0051262,biological_process protein tetramerization;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0055114,biological_process oxidation-reduction process;GO:0061045,biological_process negative regulation of wound healing;GO:0061179,biological_process negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070402,molecular_function NADPH binding;GO:0097756,biological_process negative regulation of blood vessel diameter	HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]; K00021	3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol%3BAcc:HGNC:5006]
ENSG00000167085	206.17	225.21	192.75	197.09	232.27	203.63	-0.00949648072875599	7.41907010782822	0.912019214044799	0.988638066888315	17:49404048-49414905:-	PHB	47;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001649,biological_process osteoblast differentiation;GO:0001850,molecular_function complement component C3a binding;GO:0001851,molecular_function complement component C3b binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005769,cellular_component early endosome;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0007005,biological_process mitochondrion organization;GO:0007165,biological_process signal transduction;GO:0008022,molecular_function protein C-terminus binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010942,biological_process positive regulation of cell death;GO:0010944,biological_process negative regulation of transcription by competitive promoter binding;GO:0016020,cellular_component membrane;GO:0016575,biological_process histone deacetylation;GO:0019899,molecular_function enzyme binding;GO:0030308,biological_process negative regulation of cell growth;GO:0031871,molecular_function proteinase activated receptor binding;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042826,molecular_function histone deacetylase binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043209,cellular_component myelin sheath;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045745,biological_process positive regulation of G-protein coupled receptor protein signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045917,biological_process positive regulation of complement activation;GO:0050821,biological_process protein stabilization;GO:0050847,biological_process progesterone receptor signaling pathway;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071354,biological_process cellular response to interleukin-6;GO:0071897,biological_process DNA biosynthetic process;GO:2000323,biological_process negative regulation of glucocorticoid receptor signaling pathway	NA	prohibitin [Source:HGNC Symbol%3BAcc:HGNC:8912]
ENSG00000188738	0.04	0.03	0.05	0.03	0.05	0.05	-0.102347371296425	0.0716512502197377	0.912201811882708	0.98865487588951	2:185738894-185833290:+	FSIP2	1;GO:0005739,cellular_component mitochondrion	NA	fibrous sheath interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:21675]
ENSG00000151914	12.30	12.87	12.83	12.43	13.34	12.36	0.00679637666442195	8.60086383991048	0.912218155939551	0.98865487588951	6:56457986-56954628:-	DST	47;GO:0003779,molecular_function actin binding;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005604,cellular_component basement membrane;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007010,biological_process cytoskeleton organization;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008017,molecular_function microtubule binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008090,biological_process retrograde axonal transport;GO:0008092,molecular_function cytoskeletal protein binding;GO:0009611,biological_process response to wounding;GO:0009925,cellular_component basal plasma membrane;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016887,molecular_function ATPase activity;GO:0030011,biological_process maintenance of cell polarity;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030056,cellular_component hemidesmosome;GO:0030424,cellular_component axon;GO:0031252,cellular_component cell leading edge;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031673,cellular_component H zone;GO:0035371,cellular_component microtubule plus-end;GO:0042995,cellular_component cell projection;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0046872,molecular_function metal ion binding;GO:0048870,biological_process cell motility;GO:0051010,molecular_function microtubule plus-end binding;GO:0070062,cellular_component extracellular exosome;GO:1904115,cellular_component axon cytoplasm	NA	dystonin [Source:HGNC Symbol%3BAcc:HGNC:1090]
ENSG00000156218	4.56	4.88	4.98	4.87	5.05	4.73	-0.0112534203582893	4.63861446515668	0.912273660552521	0.98865487588951	15:83654085-84039842:+	ADAMTSL3	8;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	ADAMTS like 3 [Source:HGNC Symbol%3BAcc:HGNC:14633]
ENSG00000162779	0.35	0.31	0.27	0.35	0.22	0.32	0.0650189945667478	0.10654189537467	0.91236273036193	0.988665087034713	1:179365719-179554735:+	AXDND1	NA	NA	axonemal dynein light chain domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26564]
ENSG00000141568	18.37	18.04	19.18	19.65	18.62	17.46	0.0101739179466233	5.35690543046559	0.912511880251141	0.988740395387344	17:82519712-82644662:+	FOXK2	18;GO:0000287,molecular_function magnesium ion binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016579,biological_process protein deubiquitination;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	forkhead box K2 [Source:HGNC Symbol%3BAcc:HGNC:6036]
ENSG00000136869	2.69	2.35	2.78	2.20	2.62	2.96	0.0252669514155186	2.75097833737084	0.912755143776369	0.988917657300871	9:117704331-117716871:+	TLR4	105;GO:0000187,biological_process activation of MAPK activity;GO:0001530,molecular_function lipopolysaccharide binding;GO:0001875,molecular_function lipopolysaccharide receptor activity;GO:0002218,biological_process activation of innate immune response;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002322,biological_process B cell proliferation involved in immune response;GO:0002376,biological_process immune system process;GO:0002537,biological_process nitric oxide production involved in inflammatory response;GO:0002730,biological_process regulation of dendritic cell cytokine production;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007252,biological_process I-kappaB phosphorylation;GO:0009617,biological_process response to bacterium;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010008,cellular_component endosome membrane;GO:0010572,biological_process positive regulation of platelet activation;GO:0010628,biological_process positive regulation of gene expression;GO:0014002,biological_process astrocyte development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016046,biological_process detection of fungus;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031226,cellular_component intrinsic component of plasma membrane;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032496,biological_process response to lipopolysaccharide;GO:0032497,biological_process detection of lipopolysaccharide;GO:0032609,biological_process interferon-gamma production;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032700,biological_process negative regulation of interleukin-17 production;GO:0032707,biological_process negative regulation of interleukin-23 production;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032722,biological_process positive regulation of chemokine production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032732,biological_process positive regulation of interleukin-1 production;GO:0032733,biological_process positive regulation of interleukin-10 production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032757,biological_process positive regulation of interleukin-8 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0034128,biological_process negative regulation of MyD88-independent toll-like receptor signaling pathway;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0035666,biological_process TRIF-dependent toll-like receptor signaling pathway;GO:0042088,biological_process T-helper 1 type immune response;GO:0042116,biological_process macrophage activation;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0042535,biological_process positive regulation of tumor necrosis factor biosynthetic process;GO:0042742,biological_process defense response to bacterium;GO:0043032,biological_process positive regulation of macrophage activation;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043235,cellular_component receptor complex;GO:0045084,biological_process positive regulation of interleukin-12 biosynthetic process;GO:0045087,biological_process innate immune response;GO:0045348,biological_process positive regulation of MHC class II biosynthetic process;GO:0045359,biological_process positive regulation of interferon-beta biosynthetic process;GO:0045416,biological_process positive regulation of interleukin-8 biosynthetic process;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045671,biological_process negative regulation of osteoclast differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046696,cellular_component lipopolysaccharide receptor complex;GO:0046982,molecular_function protein heterodimerization activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050671,biological_process positive regulation of lymphocyte proliferation;GO:0050702,biological_process interleukin-1 beta secretion;GO:0050707,biological_process regulation of cytokine secretion;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050727,biological_process regulation of inflammatory response;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051770,biological_process positive regulation of nitric-oxide synthase biosynthetic process;GO:0060729,biological_process intestinal epithelial structure maintenance;GO:0060907,biological_process positive regulation of macrophage cytokine production;GO:0070266,biological_process necroptotic process;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070430,biological_process positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070434,biological_process positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071223,biological_process cellular response to lipoteichoic acid;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0097190,biological_process apoptotic signaling pathway;GO:0140052,Biological_Process cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017,biological_process positive regulation of cytokine production involved in inflammatory response;GO:1900227,biological_process positive regulation of NLRP3 inflammasome complex assembly;GO:1903223,biological_process positive regulation of oxidative stress-induced neuron death;GO:1903428,biological_process positive regulation of reactive oxygen species biosynthetic process;GO:1904646,biological_process cellular response to beta-amyloid	TLR4, CD284; toll-like receptor 4; K10160	toll like receptor 4 [Source:HGNC Symbol%3BAcc:HGNC:11850]
ENSG00000106089	9.37	8.40	10.04	11.13	6.59	9.92	0.0236242386302054	3.33380429262312	0.912959118672808	0.989052325020559	7:73699205-73719672:-	STX1A	65;GO:0000149,molecular_function SNARE binding;GO:0001956,biological_process positive regulation of neurotransmitter secretion;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0007269,biological_process neurotransmitter secretion;GO:0008021,cellular_component synaptic vesicle;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0009629,biological_process response to gravity;GO:0010701,biological_process positive regulation of norepinephrine secretion;GO:0010807,biological_process regulation of synaptic vesicle priming;GO:0014047,biological_process glutamate secretion;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016081,biological_process synaptic vesicle docking;GO:0016192,biological_process vesicle-mediated transport;GO:0017022,molecular_function myosin binding;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0017157,biological_process regulation of exocytosis;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0019869,molecular_function chloride channel inhibitor activity;GO:0019900,molecular_function kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030141,cellular_component secretory granule;GO:0030672,cellular_component synaptic vesicle membrane;GO:0030674,molecular_function protein binding, bridging;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0031965,cellular_component nuclear membrane;GO:0032028,molecular_function myosin head/neck binding;GO:0032940,biological_process secretion by cell;GO:0033605,biological_process positive regulation of catecholamine secretion;GO:0035493,biological_process SNARE complex assembly;GO:0042641,cellular_component actomyosin;GO:0042734,cellular_component presynaptic membrane;GO:0043005,cellular_component neuron projection;GO:0043008,molecular_function ATP-dependent protein binding;GO:0043229,cellular_component intracellular organelle;GO:0043234,cellular_component protein complex;GO:0044325,molecular_function ion channel binding;GO:0045202,cellular_component synapse;GO:0045921,biological_process positive regulation of exocytosis;GO:0045956,biological_process positive regulation of calcium ion-dependent exocytosis;GO:0046982,molecular_function protein heterodimerization activity;GO:0047485,molecular_function protein N-terminus binding;GO:0048278,biological_process vesicle docking;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048787,cellular_component presynaptic active zone membrane;GO:0050796,biological_process regulation of insulin secretion;GO:0065009,biological_process regulation of molecular function;GO:0070032,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0070033,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex;GO:0070044,cellular_component synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0072657,biological_process protein localization to membrane;GO:0098815,biological_process modulation of excitatory postsynaptic potential;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential	STX1A; syntaxin 1A; K04560	syntaxin 1A [Source:HGNC Symbol%3BAcc:HGNC:11433]
ENSG00000116127	3.21	3.29	2.72	2.81	3.34	3.07	0.00937396988655593	5.27191751414557	0.913066726372431	0.989082579148354	2:73385757-73610793:+	ALMS1	23;GO:0001736,biological_process establishment of planar polarity;GO:0005622,cellular_component intracellular;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0007286,biological_process spermatid development;GO:0007605,biological_process sensory perception of sound;GO:0016197,biological_process endosomal transport;GO:0019722,biological_process calcium-mediated signaling;GO:0030728,biological_process ovulation;GO:0036064,cellular_component ciliary basal body;GO:0040015,biological_process negative regulation of multicellular organism growth;GO:0042593,biological_process glucose homeostasis;GO:0042632,biological_process cholesterol homeostasis;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045444,biological_process fat cell differentiation;GO:0045598,biological_process regulation of fat cell differentiation;GO:0046548,biological_process retinal rod cell development;GO:0050673,biological_process epithelial cell proliferation;GO:0051393,molecular_function alpha-actinin binding;GO:0051492,biological_process regulation of stress fiber assembly;GO:0060122,biological_process inner ear receptor stereocilium organization;GO:0060271,biological_process cilium morphogenesis	NA	ALMS1%2C centrosome and basal body associated protein [Source:HGNC Symbol%3BAcc:HGNC:428]
ENSG00000213085	0.67	0.28	0.57	0.35	0.36	0.75	0.096530749331162	0.0179990130558696	0.91322850547232	0.989171504225821	1:159872363-159900163:-	CFAP45	4;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005929,cellular_component cilium;GO:0042995,cellular_component cell projection	NA	cilia and flagella associated protein 45 [Source:HGNC Symbol%3BAcc:HGNC:17229]
ENSG00000143155	50.39	53.51	57.80	53.60	51.47	56.91	0.00846441730553867	5.49751116878245	0.913506157712019	0.989332824178204	1:168178932-168202114:+	TIPRL	4;GO:0000077,biological_process DNA damage checkpoint;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0032515,biological_process negative regulation of phosphoprotein phosphatase activity	NA	TOR signaling pathway regulator [Source:HGNC Symbol%3BAcc:HGNC:30231]
ENSG00000130159	18.35	17.86	17.18	19.15	18.99	16.13	-0.0101445236957347	4.74132929995576	0.913536842884925	0.989332824178204	19:11505915-11529174:-	ECSIT	13;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0045087,biological_process innate immune response;GO:0051341,biological_process regulation of oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	ECSIT; evolutionarily conserved signaling intermediate in Toll pathway; K04405	ECSIT signalling integrator [Source:HGNC Symbol%3BAcc:HGNC:29548]
ENSG00000126522	26.12	25.76	24.38	25.12	24.25	27.98	-0.0105497911636826	5.16562299554671	0.913986047107705	0.989671292874451	7:66075797-66093558:+	ASL	16;GO:0000050,biological_process urea cycle;GO:0003824,molecular_function catalytic activity;GO:0004056,molecular_function argininosuccinate lyase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006520,biological_process cellular amino acid metabolic process;GO:0006526,biological_process arginine biosynthetic process;GO:0007626,biological_process locomotory behavior;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009791,biological_process post-embryonic development;GO:0016829,molecular_function lyase activity;GO:0019676,biological_process ammonia assimilation cycle;GO:0042450,biological_process arginine biosynthetic process via ornithine;GO:0042802,molecular_function identical protein binding;GO:0070062,cellular_component extracellular exosome	argH, ASL; argininosuccinate lyase [EC:4.3.2.1]; K01755	argininosuccinate lyase [Source:HGNC Symbol%3BAcc:HGNC:746]
ENSG00000077721	78.53	73.99	84.72	80.74	81.08	76.22	0.0109777618299614	5.41524590781518	0.914008837630928	0.989671292874451	X:119574466-119591083:+	UBE2A	29;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000785,cellular_component chromatin;GO:0000790,cellular_component nuclear chromatin;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006301,biological_process postreplication repair;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009411,biological_process response to UV;GO:0016567,biological_process protein ubiquitination;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033503,cellular_component HULC complex;GO:0033522,biological_process histone H2A ubiquitination;GO:0043130,molecular_function ubiquitin binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0061631,molecular_function ubiquitin conjugating enzyme activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:0070979,biological_process protein K11-linked ubiquitination	UBE2A, UBC2, RAD6A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]; K10573	ubiquitin conjugating enzyme E2 A [Source:HGNC Symbol%3BAcc:HGNC:12472]
ENSG00000204463	72.11	77.27	70.89	73.51	77.58	69.80	0.00704551533666498	8.02179605914682	0.914153055154858	0.989741114141932	6:31639027-31652705:-	BAG6	50;GO:0001822,biological_process kidney development;GO:0002376,biological_process immune system process;GO:0002429,biological_process immune response-activating cell surface receptor signaling pathway;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006810,biological_process transport;GO:0006915,biological_process apoptotic process;GO:0007130,biological_process synaptonemal complex assembly;GO:0007283,biological_process spermatogenesis;GO:0007420,biological_process brain development;GO:0009790,biological_process embryo development;GO:0010498,biological_process proteasomal protein catabolic process;GO:0015643,molecular_function toxic substance binding;GO:0016020,cellular_component membrane;GO:0016569,biological_process covalent chromatin modification;GO:0018393,biological_process internal peptidyl-lysine acetylation;GO:0030101,biological_process natural killer cell activation;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030544,molecular_function Hsp70 protein binding;GO:0031593,molecular_function polyubiquitin binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032435,biological_process negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042127,biological_process regulation of cell proliferation;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042981,biological_process regulation of apoptotic process;GO:0043022,molecular_function ribosome binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045861,biological_process negative regulation of proteolysis;GO:0050821,biological_process protein stabilization;GO:0051787,molecular_function misfolded protein binding;GO:0061857,biological_process endoplasmic reticulum stress-induced pre-emptive quality control;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070062,cellular_component extracellular exosome;GO:0070628,molecular_function proteasome binding;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:0071816,biological_process tail-anchored membrane protein insertion into ER membrane;GO:0071818,cellular_component BAT3 complex;GO:1904294,biological_process positive regulation of ERAD pathway;GO:1904378,biological_process maintenance of unfolded protein involved in ERAD pathway;GO:1904379,biological_process protein localization to cytosolic proteasome complex involved in ERAD pathway;GO:1990381,molecular_function ubiquitin-specific protease binding	NA	BCL2 associated athanogene 6 [Source:HGNC Symbol%3BAcc:HGNC:13919]
ENSG00000172380	237.05	243.34	212.28	233.63	247.19	221.37	-0.00977130878066922	5.6540169499086	0.914344587027814	0.989862145366846	1:67701465-67833467:-	GNG12	14;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0021987,biological_process cerebral cortex development;GO:0030165,molecular_function PDZ domain binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0042301,molecular_function phosphate ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071377,biological_process cellular response to glucagon stimulus	NA	G protein subunit gamma 12 [Source:HGNC Symbol%3BAcc:HGNC:19663]
ENSG00000152229	1.03	0.37	1.21	0.94	0.73	0.82	0.131775893570916	0.0712790774810932	0.914571897016471	0.989919618142484	18:45983535-46072272:-	PSTPIP2	7;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007010,biological_process cytoskeleton organization;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration	NA	proline-serine-threonine phosphatase interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:9581]
ENSG00000198467	27.22	22.37	31.86	32.11	22.72	28.25	-0.0127966561790466	5.07891228957741	0.914714438402396	0.989919618142484	9:35681991-35691020:-	TPM2	16;GO:0003779,molecular_function actin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005862,cellular_component muscle thin filament tropomyosin;GO:0005884,cellular_component actin filament;GO:0006936,biological_process muscle contraction;GO:0007015,biological_process actin filament organization;GO:0008307,molecular_function structural constituent of muscle;GO:0015629,cellular_component actin cytoskeleton;GO:0030049,biological_process muscle filament sliding;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043462,biological_process regulation of ATPase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0051015,molecular_function actin filament binding	TPM2; tropomyosin 2; K10374	tropomyosin 2 [Source:HGNC Symbol%3BAcc:HGNC:12011]
ENSG00000213977	110.50	109.69	108.42	110.30	115.60	107.37	-0.0080044868861836	5.36486153276261	0.914796292430574	0.989919618142484	17:3662895-3668682:-	TAX1BP3	20;GO:0001650,cellular_component fibrillar center;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007266,biological_process Rho protein signal transduction;GO:0008013,molecular_function beta-catenin binding;GO:0008022,molecular_function protein C-terminus binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030111,biological_process regulation of Wnt signaling pathway;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome;GO:0090630,biological_process activation of GTPase activity;GO:2000009,biological_process negative regulation of protein localization to cell surface	NA	Tax1 binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:30684]
ENSG00000175787	1.49	1.89	1.80	1.80	1.75	1.75	-0.0313539117933359	1.94594878427459	0.914799413172182	0.989919618142484	9:94259310-94301454:+	ZNF169	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 169 [Source:HGNC Symbol%3BAcc:HGNC:12957]
ENSG00000159314	3.09	3.81	3.32	3.46	2.81	3.87	0.0125265612221627	3.29654262041174	0.914928508479635	0.989919618142484	17:45393901-45434421:-	ARHGAP27	12;GO:0005096,molecular_function GTPase activator activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006897,biological_process endocytosis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0017124,molecular_function SH3 domain binding;GO:0043547,biological_process positive regulation of GTPase activity	NA	Rho GTPase activating protein 27 [Source:HGNC Symbol%3BAcc:HGNC:31813]
ENSG00000079691	30.34	31.53	29.30	29.36	33.00	30.02	-0.00790981356937857	7.06913716303865	0.915060266108825	0.989919618142484	6:25279077-25620530:+	CARMIL1	30;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0007015,biological_process actin filament organization;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0016607,cellular_component nuclear speck;GO:0030027,cellular_component lamellipodium;GO:0030032,biological_process lamellipodium assembly;GO:0030335,biological_process positive regulation of cell migration;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031252,cellular_component cell leading edge;GO:0031529,biological_process ruffle organization;GO:0031941,cellular_component filamentous actin;GO:0032403,molecular_function protein complex binding;GO:0042995,cellular_component cell projection;GO:0044351,biological_process macropinocytosis;GO:0044354,cellular_component macropinosome;GO:0046415,biological_process urate metabolic process;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051638,biological_process barbed-end actin filament uncapping;GO:0051639,biological_process actin filament network formation;GO:0070062,cellular_component extracellular exosome;GO:1900026,biological_process positive regulation of substrate adhesion-dependent cell spreading;GO:1902745,biological_process positive regulation of lamellipodium organization;GO:2000813,biological_process negative regulation of barbed-end actin filament capping	NA	capping protein regulator and myosin 1 linker 1 [Source:HGNC Symbol%3BAcc:HGNC:21581]
ENSG00000119421	84.86	83.90	82.16	81.11	85.40	85.04	0.00785807153572953	5.43923745380122	0.915198030764608	0.989919618142484	9:122144057-122159819:-	NDUFA8	11;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0032403,molecular_function protein complex binding;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8; K03952	NADH:ubiquinone oxidoreductase subunit A8 [Source:HGNC Symbol%3BAcc:HGNC:7692]
ENSG00000102119	71.92	66.34	71.09	68.58	72.46	69.12	0.00941542564235151	5.74142611925677	0.91543251949253	0.989919618142484	X:154379196-154381523:+	EMD	27;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005637,cellular_component nuclear inner membrane;GO:0005640,cellular_component nuclear outer membrane;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005874,cellular_component microtubule;GO:0006936,biological_process muscle contraction;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0007517,biological_process muscle organ development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031616,cellular_component spindle pole centrosome;GO:0031965,cellular_component nuclear membrane;GO:0032541,cellular_component cortical endoplasmic reticulum;GO:0035414,biological_process negative regulation of catenin import into nucleus;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0045296,molecular_function cadherin binding;GO:0046827,biological_process positive regulation of protein export from nucleus;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0048487,molecular_function beta-tubulin binding;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0071363,biological_process cellular response to growth factor stimulus	EMD; emerin; K12569	emerin [Source:HGNC Symbol%3BAcc:HGNC:3331]
ENSG00000148339	1.97	1.59	1.76	1.94	1.93	1.65	-0.026289482143357	1.94931130470164	0.915457231865577	0.989919618142484	9:128068200-128109245:+	SLC25A25	23;GO:0002021,biological_process response to dietary excess;GO:0005347,molecular_function ATP transmembrane transporter activity;GO:0005509,molecular_function calcium ion binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0014823,biological_process response to activity;GO:0015217,molecular_function ADP transmembrane transporter activity;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032094,biological_process response to food;GO:0035264,biological_process multicellular organism growth;GO:0043010,biological_process camera-type eye development;GO:0045333,biological_process cellular respiration;GO:0046034,biological_process ATP metabolic process;GO:0046872,molecular_function metal ion binding;GO:0055085,biological_process transmembrane transport;GO:0060612,biological_process adipose tissue development;GO:0070062,cellular_component extracellular exosome;GO:0070588,biological_process calcium ion transmembrane transport	NA	solute carrier family 25 member 25 [Source:HGNC Symbol%3BAcc:HGNC:20663]
ENSG00000178802	17.97	19.02	18.52	17.76	20.00	17.81	0.0088738573457523	5.01020716219727	0.915481091216384	0.989919618142484	15:74890004-74902219:+	MPI	12;GO:0000032,biological_process cell wall mannoprotein biosynthetic process;GO:0004476,molecular_function mannose-6-phosphate isomerase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0008270,molecular_function zinc ion binding;GO:0009298,biological_process GDP-mannose biosynthetic process;GO:0016853,molecular_function isomerase activity;GO:0046872,molecular_function metal ion binding;GO:0061611,biological_process mannose to fructose-6-phosphate metabolic process;GO:0070062,cellular_component extracellular exosome	manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]; K01809	mannose phosphate isomerase [Source:HGNC Symbol%3BAcc:HGNC:7216]
ENSG00000237441	48.08	49.03	49.54	48.18	49.26	49.71	0.00663184567854026	6.83752354469515	0.915558256053303	0.989919618142484	6:33291653-33299324:-	RGL2	13;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0032485,biological_process regulation of Ral protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	ral guanine nucleotide dissociation stimulator like 2 [Source:HGNC Symbol%3BAcc:HGNC:9769]
ENSG00000130545	15.31	18.27	13.55	15.53	21.04	11.64	-0.0258270095634431	2.79044446084607	0.915586185185157	0.989919618142484	19:6463776-6467221:+	CRB3	14;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0017124,molecular_function SH3 domain binding;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0043234,cellular_component protein complex;GO:0045177,cellular_component apical part of cell;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly;GO:0072659,biological_process protein localization to plasma membrane	CRB3; crumbs 3; K06090	crumbs 3%2C cell polarity complex component [Source:HGNC Symbol%3BAcc:HGNC:20237]
ENSG00000102384	8.37	9.48	7.40	8.81	8.79	7.56	0.0101466726395881	4.2595897836227	0.915742121679666	0.989919618142484	X:101098217-101163681:+	CENPI	12;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007062,biological_process sister chromatid cohesion;GO:0007548,biological_process sex differentiation;GO:0016604,cellular_component nuclear body;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0034508,biological_process centromere complex assembly	NA	centromere protein I [Source:HGNC Symbol%3BAcc:HGNC:3968]
ENSG00000155876	168.86	169.66	177.54	175.26	174.30	168.34	0.00688583556899359	7.34056295269064	0.915764136941371	0.989919618142484	9:19049394-19050983:+	RRAGA	30;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007050,biological_process cell cycle arrest;GO:0008219,biological_process cell death;GO:0010507,biological_process negative regulation of autophagy;GO:0016032,biological_process viral process;GO:0016241,biological_process regulation of macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0019048,biological_process modulation by virus of host morphology or physiology;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032008,biological_process positive regulation of TOR signaling;GO:0034198,biological_process cellular response to amino acid starvation;GO:0034448,cellular_component EGO complex;GO:0034613,biological_process cellular protein localization;GO:0042803,molecular_function protein homodimerization activity;GO:0045919,biological_process positive regulation of cytolysis;GO:0046982,molecular_function protein heterodimerization activity;GO:0051219,molecular_function phosphoprotein binding;GO:0071230,biological_process cellular response to amino acid stimulus;GO:1904263,biological_process positive regulation of TORC1 signaling;GO:1990130,cellular_component Iml1 complex;GO:1990131,cellular_component Gtr1-Gtr2 GTPase complex	RRAGA_B; Ras-related GTP-binding protein A/B; K16185	Ras related GTP binding A [Source:HGNC Symbol%3BAcc:HGNC:16963]
ENSG00000149932	73.95	69.16	71.32	73.20	70.39	71.63	0.00843675387175111	5.85805096610385	0.915788911584523	0.989919618142484	16:29940884-29973052:+	TMEM219	5;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042981,biological_process regulation of apoptotic process	NA	transmembrane protein 219 [Source:HGNC Symbol%3BAcc:HGNC:25201]
ENSG00000006695	11.10	11.67	12.33	10.20	13.16	11.73	0.0120240923890698	3.98772494565643	0.915857531314032	0.989919618142484	17:14069495-14208677:+	COX10	24;GO:0000266,biological_process mitochondrial fission;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0004311,molecular_function farnesyltranstransferase activity;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005829,cellular_component cytosol;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0006783,biological_process heme biosynthetic process;GO:0006784,biological_process heme a biosynthetic process;GO:0007005,biological_process mitochondrion organization;GO:0008495,molecular_function protoheme IX farnesyltransferase activity;GO:0008535,biological_process respiratory chain complex IV assembly;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016765,molecular_function transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0017004,biological_process cytochrome complex assembly;GO:0031966,cellular_component mitochondrial membrane;GO:0045333,biological_process cellular respiration;GO:0048034,biological_process heme O biosynthetic process;GO:0070069,cellular_component cytochrome complex;GO:1902600,biological_process hydrogen ion transmembrane transport	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]; K02257	COX10%2C heme A:farnesyltransferase cytochrome c oxidase assembly factor [Source:HGNC Symbol%3BAcc:HGNC:2260]
ENSG00000177951	18.70	19.39	18.42	18.64	18.79	18.90	0.0133611189862671	3.85022959823421	0.915930648528711	0.989919618142484	11:167783-207428:-	BET1L	14;GO:0000139,cellular_component Golgi membrane;GO:0005484,molecular_function SNAP receptor activity;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031201,cellular_component SNARE complex;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0061025,biological_process membrane fusion;GO:2000156,biological_process regulation of retrograde vesicle-mediated transport, Golgi to ER	BET1; blocked early in transport 1; K08504	Bet1 golgi vesicular membrane trafficking protein like [Source:HGNC Symbol%3BAcc:HGNC:19348]
ENSG00000138160	15.00	16.86	12.85	14.72	16.61	14.03	-0.0127428144933059	5.57406789936782	0.916130554311792	0.989919618142484	10:92593285-92655395:+	KIF11	29;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007018,biological_process microtubule-based movement;GO:0007049,biological_process cell cycle;GO:0007051,biological_process spindle organization;GO:0007052,biological_process mitotic spindle organization;GO:0007059,biological_process chromosome segregation;GO:0007100,biological_process mitotic centrosome separation;GO:0008017,molecular_function microtubule binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0016020,cellular_component membrane;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019901,molecular_function protein kinase binding;GO:0032403,molecular_function protein complex binding;GO:0046602,biological_process regulation of mitotic centrosome separation;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0090307,biological_process mitotic spindle assembly	NA	kinesin family member 11 [Source:HGNC Symbol%3BAcc:HGNC:6388]
ENSG00000154957	7.63	6.27	7.69	6.96	7.74	6.92	0.0221013141275816	3.5916804855036	0.916518430687	0.989919618142484	17:11977438-11997510:-	ZNF18	11;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 18 [Source:HGNC Symbol%3BAcc:HGNC:12969]
ENSG00000119699	0.86	0.70	0.77	0.73	1.10	0.68	-0.0802991524228031	0.204919976095868	0.916528054862471	0.989919618142484	14:75958098-75982991:-	TGFB3	73;GO:0000187,biological_process activation of MAPK activity;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0002576,biological_process platelet degranulation;GO:0005114,molecular_function type II transforming growth factor beta receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007435,biological_process salivary gland morphogenesis;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0008083,molecular_function growth factor activity;GO:0008156,biological_process negative regulation of DNA replication;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009986,cellular_component cell surface;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0010936,biological_process negative regulation of macrophage cytokine production;GO:0016049,biological_process cell growth;GO:0030141,cellular_component secretory granule;GO:0030315,cellular_component T-tubule;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030879,biological_process mammary gland development;GO:0031012,cellular_component extracellular matrix;GO:0031093,cellular_component platelet alpha granule lumen;GO:0032570,biological_process response to progesterone;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0034616,biological_process response to laminar fluid shear stress;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0034714,molecular_function type III transforming growth factor beta receptor binding;GO:0042060,biological_process wound healing;GO:0042476,biological_process odontogenesis;GO:0042704,biological_process uterine wall breakdown;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043408,biological_process regulation of MAPK cascade;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043627,biological_process response to estrogen;GO:0043932,biological_process ossification involved in bone remodeling;GO:0045216,biological_process cell-cell junction organization;GO:0045740,biological_process positive regulation of DNA replication;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity;GO:0048286,biological_process lung alveolus development;GO:0048468,biological_process cell development;GO:0048565,biological_process digestive tract development;GO:0048702,biological_process embryonic neurocranium morphogenesis;GO:0048839,biological_process inner ear development;GO:0050431,molecular_function transforming growth factor beta binding;GO:0050714,biological_process positive regulation of protein secretion;GO:0051491,biological_process positive regulation of filopodium assembly;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051781,biological_process positive regulation of cell division;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis;GO:0060364,biological_process frontal suture morphogenesis;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus;GO:0060395,biological_process SMAD protein signal transduction;GO:0070483,biological_process detection of hypoxia;GO:1904706,biological_process negative regulation of vascular smooth muscle cell proliferation;GO:1905075,biological_process positive regulation of occluding junction disassembly	TGFB3; transforming growth factor beta-3; K13377	transforming growth factor beta 3 [Source:HGNC Symbol%3BAcc:HGNC:11769]
ENSG00000119285	18.74	18.38	17.87	18.16	18.30	18.72	0.00664808802845685	6.88684849742783	0.916582094000075	0.989919618142484	1:236549004-236604504:-	HEATR1	20;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001650,cellular_component fibrillar center;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0016020,cellular_component membrane;GO:0030515,molecular_function snoRNA binding;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030686,cellular_component 90S preribosome;GO:0032040,cellular_component small-subunit processome;GO:0034455,cellular_component t-UTP complex;GO:0042254,biological_process ribosome biogenesis;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:2000234,biological_process positive regulation of rRNA processing	UTP10, HEATR1; U3 small nucleolar RNA-associated protein 10; K14550	HEAT repeat containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25517]
ENSG00000196912	1.85	1.44	1.82	1.91	1.68	1.67	-0.0147782503201787	2.91216895104184	0.916719346474983	0.989919618142484	2:97492662-97589965:-	ANKRD36B	1;GO:0005515,molecular_function protein binding	NA	ankyrin repeat domain 36B [Source:HGNC Symbol%3BAcc:HGNC:29333]
ENSG00000090061	37.91	41.83	36.65	40.27	38.68	37.62	0.00640311737431291	6.09467673714289	0.916739533766636	0.989919618142484	14:99481168-99535044:+	CCNK	25;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0002944,cellular_component cyclin K-CDK12 complex;GO:0002945,cellular_component cyclin K-CDK13 complex;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901,molecular_function protein kinase binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0044828,biological_process negative regulation by host of viral genome replication;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051301,biological_process cell division;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:2001165,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues	NA	cyclin K [Source:HGNC Symbol%3BAcc:HGNC:1596]
ENSG00000197608	9.91	10.07	9.53	9.37	9.44	10.70	0.00825463171033939	4.77795566948563	0.916880869215435	0.989919618142484	19:52064465-52095765:-	ZNF841	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 841 [Source:HGNC Symbol%3BAcc:HGNC:27611]
ENSG00000126246	2.93	3.11	3.86	3.52	3.56	3.11	-0.0245127056650178	1.94990746546762	0.91689022983446	0.989919618142484	19:35738800-35742453:-	IGFLR1	4;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	IGF like family receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:23620]
ENSG00000137073	18.93	20.07	19.78	19.49	20.42	19.02	0.00685376076103082	6.04495235505635	0.916979690826785	0.989919618142484	9:33921692-34048949:-	UBAP2	5;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0010628,biological_process positive regulation of gene expression;GO:0045296,molecular_function cadherin binding	NA	ubiquitin associated protein 2 [Source:HGNC Symbol%3BAcc:HGNC:14185]
ENSG00000162384	79.01	72.27	72.83	76.43	72.68	78.38	-0.00771422181837307	5.18328105491145	0.917090708610635	0.989919618142484	1:53214098-53220617:-	C1orf123	3;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome	NA	chromosome 1 open reading frame 123 [Source:HGNC Symbol%3BAcc:HGNC:26059]
ENSG00000136436	60.15	55.15	61.77	62.36	55.25	61.99	-0.00712177691757706	6.66727419338558	0.917120167789742	0.989919618142484	17:48830987-48866522:+	CALCOCO2	17;GO:0000421,cellular_component autophagosome membrane;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006914,biological_process autophagy;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034341,biological_process response to interferon-gamma;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0098792,biological_process xenophagy;GO:1901098,biological_process positive regulation of autophagosome maturation	NA	calcium binding and coiled-coil domain 2 [Source:HGNC Symbol%3BAcc:HGNC:29912]
ENSG00000166887	24.43	26.90	27.26	27.15	26.57	25.05	0.00723030807775611	6.14174294864861	0.917135501557075	0.989919618142484	15:42158700-42208316:-	VPS39	20;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006914,biological_process autophagy;GO:0008333,biological_process endosome to lysosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030123,cellular_component AP-3 adaptor complex;GO:0030897,cellular_component HOPS complex;GO:0031902,cellular_component late endosome membrane;GO:0034058,biological_process endosomal vesicle fusion;GO:0097576,biological_process vacuole fusion;GO:1902774,biological_process late endosome to lysosome transport;GO:1990126,biological_process retrograde transport, endosome to plasma membrane	NA	VPS39%2C HOPS complex subunit [Source:HGNC Symbol%3BAcc:HGNC:20593]
ENSG00000171159	78.28	91.73	87.79	84.49	95.95	81.33	-0.0143715579191325	4.43818761977337	0.917204433141951	0.989919618142484	9:128160259-128163928:+	C9orf16	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	chromosome 9 open reading frame 16 [Source:HGNC Symbol%3BAcc:HGNC:17823]
ENSG00000100813	58.01	64.17	57.83	58.74	64.48	57.28	0.00713502784338426	8.01397532772828	0.917280664357134	0.989919618142484	14:23058563-23095614:-	ACIN1	19;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0016887,molecular_function ATPase activity;GO:0019899,molecular_function enzyme binding;GO:0030218,biological_process erythrocyte differentiation;GO:0030263,biological_process apoptotic chromosome condensation;GO:0045657,biological_process positive regulation of monocyte differentiation;GO:0061574,cellular_component ASAP complex;GO:0097194,biological_process execution phase of apoptosis	ACIN1, ACINUS; apoptotic chromatin condensation inducer in the nucleus; K12875	apoptotic chromatin condensation inducer 1 [Source:HGNC Symbol%3BAcc:HGNC:17066]
ENSG00000168591	44.03	47.19	45.73	46.60	47.20	44.93	-0.00907814237915657	5.47389862313294	0.917417191624161	0.989919618142484	17:44186969-44191731:+	TMUB2	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane and ubiquitin like domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:28459]
ENSG00000112293	0.22	0.49	0.35	0.21	0.51	0.42	-0.123270392434882	0.0902617707332257	0.917445875962843	0.989919618142484	6:24424564-24495205:-	GPLD1	43;GO:0001503,biological_process ossification;GO:0002042,biological_process cell migration involved in sprouting angiogenesis;GO:0002062,biological_process chondrocyte differentiation;GO:0002430,biological_process complement receptor mediated signaling pathway;GO:0004621,molecular_function glycosylphosphatidylinositol phospholipase D activity;GO:0004630,molecular_function phospholipase D activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0006501,biological_process C-terminal protein lipidation;GO:0006507,biological_process GPI anchor release;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009749,biological_process response to glucose;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010694,biological_process positive regulation of alkaline phosphatase activity;GO:0010867,biological_process positive regulation of triglyceride biosynthetic process;GO:0010897,biological_process negative regulation of triglyceride catabolic process;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0010983,biological_process positive regulation of high-density lipoprotein particle clearance;GO:0016787,molecular_function hydrolase activity;GO:0017080,molecular_function sodium channel regulator activity;GO:0032869,biological_process cellular response to insulin stimulus;GO:0035690,biological_process cellular response to drug;GO:0035701,biological_process hematopoietic stem cell migration;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045919,biological_process positive regulation of cytolysis;GO:0046470,biological_process phosphatidylcholine metabolic process;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0051047,biological_process positive regulation of secretion;GO:0070062,cellular_component extracellular exosome;GO:0070633,biological_process transepithelial transport;GO:0071277,biological_process cellular response to calcium ion;GO:0071397,biological_process cellular response to cholesterol;GO:0071401,biological_process cellular response to triglyceride;GO:0071467,biological_process cellular response to pH;GO:0097241,biological_process hematopoietic stem cell migration to bone marrow;GO:1900076,biological_process regulation of cellular response to insulin stimulus	GPLD1; glycosylphosphatidylinositol phospholipase D [EC:3.1.4.50]; K01127	glycosylphosphatidylinositol specific phospholipase D1 [Source:HGNC Symbol%3BAcc:HGNC:4459]
ENSG00000162062	3.12	2.67	2.38	2.70	3.01	2.38	0.0330131137453253	1.9404660338132	0.91745853175236	0.989919618142484	16:2460079-2464963:+	C16orf59	1;GO:0005515,molecular_function protein binding	NA	chromosome 16 open reading frame 59 [Source:HGNC Symbol%3BAcc:HGNC:25849]
ENSG00000171606	9.12	8.39	10.82	10.70	8.71	9.48	-0.0105565737781758	4.23995317597422	0.91755676929808	0.989919618142484	19:58183028-58213562:+	ZNF274	16;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding;GO:1900112,biological_process regulation of histone H3-K9 trimethylation;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	ZNF274; zinc finger protein 274; K12458	zinc finger protein 274 [Source:HGNC Symbol%3BAcc:HGNC:13068]
ENSG00000235169	4.81	4.88	4.07	3.82	4.20	5.09	0.0708882988082061	0.267105324685004	0.917669808183886	0.989919618142484	1:3772787-3775982:+	SMIM1	4;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	small integral membrane protein 1 (Vel blood group) [Source:HGNC Symbol%3BAcc:HGNC:44204]
ENSG00000148832	2.71	2.07	1.91	2.36	2.02	2.26	0.031026386625728	1.91075700684996	0.91784465995036	0.989919618142484	10:133379233-133391694:+	PAOX	20;GO:0005102,molecular_function receptor binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0006596,biological_process polyamine biosynthetic process;GO:0006598,biological_process polyamine catabolic process;GO:0008215,biological_process spermine metabolic process;GO:0009446,biological_process putrescine biosynthetic process;GO:0009447,biological_process putrescine catabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0046203,biological_process spermidine catabolic process;GO:0046208,biological_process spermine catabolic process;GO:0046592,molecular_function polyamine oxidase activity;GO:0052899,molecular_function N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity;GO:0052901,molecular_function spermine:oxygen oxidoreductase (spermidine-forming) activity;GO:0052902,molecular_function spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity;GO:0052903,molecular_function N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity;GO:0052904,molecular_function N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity;GO:0055114,biological_process oxidation-reduction process;GO:1901307,biological_process positive regulation of spermidine biosynthetic process	PAOX; N1-acetylpolyamine oxidase [EC:1.5.3.13]; K00308	polyamine oxidase [Source:HGNC Symbol%3BAcc:HGNC:20837]
ENSG00000165376	58.04	107.06	63.89	54.47	121.79	59.01	-0.0283714751637428	5.73344918878138	0.917945287275138	0.989919618142484	X:106900163-106930861:+	CLDN2	10;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016338,biological_process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030054,cellular_component cell junction;GO:0042802,molecular_function identical protein binding;GO:0070062,cellular_component extracellular exosome	CLDN; claudin; K06087	claudin 2 [Source:HGNC Symbol%3BAcc:HGNC:2041]
ENSG00000133302	2.60	2.80	2.23	2.57	2.51	2.48	0.0159966401996477	3.02952416021491	0.917982381958659	0.989919618142484	5:94618346-94739436:+	SLF1	17;GO:0000786,cellular_component nucleosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0031334,biological_process positive regulation of protein complex assembly;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032403,molecular_function protein complex binding;GO:0034184,biological_process positive regulation of maintenance of mitotic sister chromatid cohesion;GO:0035861,cellular_component site of double-strand break;GO:0042405,cellular_component nuclear inclusion body;GO:1990166,biological_process protein localization to site of double-strand break;GO:2000781,biological_process positive regulation of double-strand break repair	NA	SMC5-SMC6 complex localization factor 1 [Source:HGNC Symbol%3BAcc:HGNC:25408]
ENSG00000144524	29.74	30.23	28.71	32.47	29.27	28.20	-0.00937722416035414	5.15543689622841	0.918024778442399	0.989919618142484	2:231781670-231809254:+	COPS7B	10;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0008180,cellular_component COP9 signalosome;GO:0043687,biological_process post-translational protein modification	NA	COP9 signalosome subunit 7B [Source:HGNC Symbol%3BAcc:HGNC:16760]
ENSG00000164663	2.68	2.13	3.46	2.56	2.52	3.14	0.0339933657545851	2.5834705891622	0.918034229072922	0.989919618142484	6:41789895-41895361:-	USP49	20;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006397,biological_process mRNA processing;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0035616,biological_process histone H2B conserved C-terminal lysine deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042393,molecular_function histone binding;GO:0046872,molecular_function metal ion binding	NA	ubiquitin specific peptidase 49 [Source:HGNC Symbol%3BAcc:HGNC:20078]
ENSG00000198836	22.91	23.79	22.99	22.19	24.22	23.48	0.00649245470917035	6.32481431974775	0.918042934393293	0.989919618142484	3:193593143-193697823:+	OPA1	49;GO:0000002,biological_process mitochondrial genome maintenance;GO:0000166,molecular_function nucleotide binding;GO:0000266,biological_process mitochondrial fission;GO:0000287,molecular_function magnesium ion binding;GO:0003374,biological_process dynamin polymerization involved in mitochondrial fission;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0007005,biological_process mitochondrion organization;GO:0007007,biological_process inner mitochondrial membrane organization;GO:0007568,biological_process aging;GO:0007601,biological_process visual perception;GO:0008017,molecular_function microtubule binding;GO:0008053,biological_process mitochondrial fusion;GO:0010636,biological_process positive regulation of mitochondrial fusion;GO:0014042,biological_process positive regulation of neuron maturation;GO:0014850,biological_process response to muscle activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0019896,biological_process axonal transport of mitochondrion;GO:0030061,cellular_component mitochondrial crista;GO:0030425,cellular_component dendrite;GO:0031314,cellular_component extrinsic component of mitochondrial inner membrane;GO:0042981,biological_process regulation of apoptotic process;GO:0046039,biological_process GTP metabolic process;GO:0048312,biological_process intracellular distribution of mitochondria;GO:0050896,biological_process response to stimulus;GO:0051259,biological_process protein oligomerization;GO:0051602,biological_process response to electrical stimulus;GO:0061003,biological_process positive regulation of dendritic spine morphogenesis;GO:0070300,molecular_function phosphatidic acid binding;GO:0070584,biological_process mitochondrion morphogenesis;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071456,biological_process cellular response to hypoxia;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0090398,biological_process cellular senescence;GO:0097749,biological_process membrane tubulation;GO:1900006,biological_process positive regulation of dendrite development;GO:1901612,molecular_function cardiolipin binding;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1904115,cellular_component axon cytoplasm	NA	OPA1%2C mitochondrial dynamin like GTPase [Source:HGNC Symbol%3BAcc:HGNC:8140]
ENSG00000084072	25.61	23.01	24.05	23.12	26.43	23.31	0.0128481289918528	4.69345298056412	0.918063926893415	0.989919618142484	1:39692181-39763914:+	PPIE	24;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000413,biological_process protein peptidyl-prolyl isomerization;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003755,molecular_function peptidyl-prolyl cis-trans isomerase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0006457,biological_process protein folding;GO:0008380,biological_process RNA splicing;GO:0016018,molecular_function cyclosporin A binding;GO:0016607,cellular_component nuclear speck;GO:0016853,molecular_function isomerase activity;GO:0034774,cellular_component secretory granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045070,biological_process positive regulation of viral genome replication;GO:0071013,cellular_component catalytic step 2 spliceosome;GO:1904813,cellular_component ficolin-1-rich granule lumen	PPIE; peptidyl-prolyl isomerase E (cyclophilin E) [EC:5.2.1.8]; K09564	peptidylprolyl isomerase E [Source:HGNC Symbol%3BAcc:HGNC:9258]
ENSG00000049247	7.22	6.62	7.65	6.75	7.49	7.19	0.0242534913755221	2.10190100104609	0.918141337659066	0.989919618142484	1:7843082-7853512:-	UTS2	30;GO:0001666,biological_process response to hypoxia;GO:0003105,biological_process negative regulation of glomerular filtration;GO:0005102,molecular_function receptor binding;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0006936,biological_process muscle contraction;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007268,biological_process chemical synaptic transmission;GO:0008217,biological_process regulation of blood pressure;GO:0010459,biological_process negative regulation of heart rate;GO:0010460,biological_process positive regulation of heart rate;GO:0010763,biological_process positive regulation of fibroblast migration;GO:0010841,biological_process positive regulation of circadian sleep/wake cycle, wakefulness;GO:0032224,biological_process positive regulation of synaptic transmission, cholinergic;GO:0032967,biological_process positive regulation of collagen biosynthetic process;GO:0033574,biological_process response to testosterone;GO:0035811,biological_process negative regulation of urine volume;GO:0035814,biological_process negative regulation of renal sodium excretion;GO:0042493,biological_process response to drug;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045776,biological_process negative regulation of blood pressure;GO:0045777,biological_process positive regulation of blood pressure;GO:0046005,biological_process positive regulation of circadian sleep/wake cycle, REM sleep;GO:0046676,biological_process negative regulation of insulin secretion;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0097746,biological_process regulation of blood vessel diameter;GO:0097755,biological_process positive regulation of blood vessel diameter	UTS2; urotensin 2; K05248	urotensin 2 [Source:HGNC Symbol%3BAcc:HGNC:12636]
ENSG00000162366	471.87	525.05	492.61	482.51	550.41	459.95	0.00784451641691356	7.4110135061571	0.91815547001963	0.989919618142484	1:47183592-47191044:-	PDZK1IP1	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	PDZK1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:16887]
ENSG00000090432	24.68	27.51	25.93	28.43	24.92	25.84	-0.0122181208199977	4.79798836654647	0.918351630554351	0.989919618142484	1:20499447-20508161:-	MUL1	43;GO:0000266,biological_process mitochondrial fission;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005777,cellular_component peroxisome;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006996,biological_process organelle organization;GO:0007257,biological_process activation of JUN kinase activity;GO:0010637,biological_process negative regulation of mitochondrial fusion;GO:0010821,biological_process regulation of mitochondrion organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0030308,biological_process negative regulation of cell growth;GO:0030424,cellular_component axon;GO:0031307,cellular_component integral component of mitochondrial outer membrane;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031647,biological_process regulation of protein stability;GO:0031648,biological_process protein destabilization;GO:0033235,biological_process positive regulation of protein sumoylation;GO:0042802,molecular_function identical protein binding;GO:0043025,cellular_component neuronal cell body;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045824,biological_process negative regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050689,biological_process negative regulation of defense response to virus by host;GO:0050821,biological_process protein stabilization;GO:0051646,biological_process mitochondrion localization;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0051898,biological_process negative regulation of protein kinase B signaling;GO:0060339,biological_process negative regulation of type I interferon-mediated signaling pathway;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0071650,biological_process negative regulation of chemokine (C-C motif) ligand 5 production;GO:0090141,biological_process positive regulation of mitochondrial fission;GO:1901028,biological_process regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1903861,biological_process positive regulation of dendrite extension;GO:1904925,biological_process positive regulation of mitophagy in response to mitochondrial depolarization	NA	mitochondrial E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:25762]
ENSG00000135540	3.78	3.04	3.44	3.47	3.61	3.39	-0.00692115686548507	4.18244204354068	0.918429085251079	0.989919618142484	6:138422042-138692571:-	NHSL1	2;GO:0016020,cellular_component membrane;GO:0097475,biological_process motor neuron migration	NA	NHS like 1 [Source:HGNC Symbol%3BAcc:HGNC:21021]
ENSG00000115816	35.48	33.78	34.21	34.05	32.77	37.01	0.00720501917343928	6.77885948815214	0.91849085411921	0.989919618142484	2:37201611-37231713:-	CEBPZ	9;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	CCAAT/enhancer binding protein zeta [Source:HGNC Symbol%3BAcc:HGNC:24218]
ENSG00000127366	0.87	1.07	1.15	1.00	0.34	1.57	0.0723708979462765	0.0719797940526355	0.9185120874321	0.989919618142484	7:141790216-141791367:+	TAS2R5	13;GO:0001580,biological_process detection of chemical stimulus involved in sensory perception of bitter taste;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007635,biological_process chemosensory behavior;GO:0008527,molecular_function taste receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033038,molecular_function bitter taste receptor activity;GO:0050896,biological_process response to stimulus;GO:0050909,biological_process sensory perception of taste	TAS2R; taste receptor type 2; K08474	taste 2 receptor member 5 [Source:HGNC Symbol%3BAcc:HGNC:14912]
ENSG00000075790	38.93	39.34	39.81	37.77	40.55	41.32	-0.0076758077633485	5.85400176687464	0.918545988666281	0.989919618142484	7:107579976-107629170:+	BCAP29	12;GO:0001649,biological_process osteoblast differentiation;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006915,biological_process apoptotic process;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0070973,biological_process protein localization to endoplasmic reticulum exit site	NA	B-cell receptor associated protein 29 [Source:HGNC Symbol%3BAcc:HGNC:24131]
ENSG00000129933	10.20	10.55	11.07	10.98	9.81	11.03	0.0106651264477723	4.30532845158453	0.918614124429385	0.989919618142484	19:19320680-19358755:+	MAU2	13;GO:0000785,cellular_component chromatin;GO:0003690,molecular_function double-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007064,biological_process mitotic sister chromatid cohesion;GO:0016604,cellular_component nuclear body;GO:0032116,cellular_component SMC loading complex;GO:0034088,biological_process maintenance of mitotic sister chromatid cohesion;GO:0047485,molecular_function protein N-terminus binding;GO:0051301,biological_process cell division	NA	MAU2 sister chromatid cohesion factor [Source:HGNC Symbol%3BAcc:HGNC:29140]
ENSG00000177990	6.68	7.30	7.73	6.65	7.40	7.99	-0.0131777249370344	4.14834293644153	0.91865717252655	0.989919618142484	12:63558912-63668939:-	DPY19L2	12;GO:0000030,molecular_function mannosyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018406,biological_process protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan;GO:0030154,biological_process cell differentiation	NA	dpy-19 like 2 [Source:HGNC Symbol%3BAcc:HGNC:19414]
ENSG00000151320	0.53	0.49	0.51	0.50	0.44	0.63	-0.0301395848954307	1.97238672322723	0.918749506900313	0.989919618142484	14:32329272-32837681:+	AKAP6	37;GO:0001508,biological_process action potential;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005901,cellular_component caveola;GO:0006605,biological_process protein targeting;GO:0008179,molecular_function adenylate cyclase binding;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014701,cellular_component junctional sarcoplasmic reticulum membrane;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0019933,biological_process cAMP-mediated signaling;GO:0030307,biological_process positive regulation of cell growth;GO:0030315,cellular_component T-tubule;GO:0030818,biological_process negative regulation of cAMP biosynthetic process;GO:0031965,cellular_component nuclear membrane;GO:0032516,biological_process positive regulation of phosphoprotein phosphatase activity;GO:0032947,molecular_function protein complex scaffold;GO:0034237,molecular_function protein kinase A regulatory subunit binding;GO:0034704,cellular_component calcium channel complex;GO:0035556,biological_process intracellular signal transduction;GO:0043495,molecular_function protein anchor;GO:0044325,molecular_function ion channel binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051018,molecular_function protein kinase A binding;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0060306,biological_process regulation of membrane repolarization;GO:0060316,biological_process positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0061051,biological_process positive regulation of cell growth involved in cardiac muscle cell development;GO:0070886,biological_process positive regulation of calcineurin-NFAT signaling cascade;GO:0071320,biological_process cellular response to cAMP;GO:0071345,biological_process cellular response to cytokine stimulus;GO:1901381,biological_process positive regulation of potassium ion transmembrane transport;GO:1902261,biological_process positive regulation of delayed rectifier potassium channel activity	NA	A-kinase anchoring protein 6 [Source:HGNC Symbol%3BAcc:HGNC:376]
ENSG00000214413	46.15	43.59	46.32	44.33	45.24	48.73	-0.0095095533178236	4.39531611474684	0.919059394334109	0.989919618142484	10:110898729-110919274:-	BBIP1	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0030030,biological_process cell projection organization;GO:0034464,cellular_component BBSome;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097500,biological_process receptor localization to nonmotile primary cilium	NA	BBSome interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:28093]
ENSG00000173013	2.55	2.47	2.03	2.16	2.46	2.62	-0.0322104988148798	2.04146947542862	0.91906890563437	0.989919618142484	4:7040848-7042939:-	CCDC96	3;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton	NA	coiled-coil domain containing 96 [Source:HGNC Symbol%3BAcc:HGNC:26900]
ENSG00000168676	0.47	0.23	0.31	0.44	0.37	0.29	-0.0809065167768426	0.235758428712097	0.919074947686138	0.989919618142484	16:67289427-67326763:-	KCTD19	1;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 19 [Source:HGNC Symbol%3BAcc:HGNC:24753]
ENSG00000076984	20.99	19.82	19.43	19.03	21.91	19.41	0.0111304943752404	4.74509283890927	0.919113023239567	0.989919618142484	19:7903842-7914478:+	MAP2K7	36;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006970,biological_process response to osmotic stress;GO:0007165,biological_process signal transduction;GO:0007254,biological_process JNK cascade;GO:0007257,biological_process activation of JUN kinase activity;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0009408,biological_process response to heat;GO:0009411,biological_process response to UV;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019903,molecular_function protein phosphatase binding;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0034612,biological_process response to tumor necrosis factor;GO:0035897,biological_process proteolysis in other organism;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051973,biological_process positive regulation of telomerase activity;GO:1904355,biological_process positive regulation of telomere capping	MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]; K04431	mitogen-activated protein kinase kinase 7 [Source:HGNC Symbol%3BAcc:HGNC:6847]
ENSG00000139687	17.15	17.54	16.52	16.38	17.95	17.00	0.00702499681455471	5.57703751703251	0.919132538196253	0.989919618142484	13:48303750-48481986:+	RB1	84;GO:0000075,biological_process cell cycle checkpoint;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000785,cellular_component chromatin;GO:0001047,molecular_function core promoter binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001558,biological_process regulation of cell growth;GO:0001894,biological_process tissue homeostasis;GO:0003674,molecular_function molecular_function;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005819,cellular_component spindle;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0007070,biological_process negative regulation of transcription from RNA polymerase II promoter during mitosis;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007265,biological_process Ras protein signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0008134,molecular_function transcription factor binding;GO:0008150,biological_process biological_process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010629,biological_process negative regulation of gene expression;GO:0016032,biological_process viral process;GO:0016514,cellular_component SWI/SNF complex;GO:0016569,biological_process covalent chromatin modification;GO:0016605,cellular_component PML body;GO:0019899,molecular_function enzyme binding;GO:0019900,molecular_function kinase binding;GO:0030182,biological_process neuron differentiation;GO:0030521,biological_process androgen receptor signaling pathway;GO:0031134,biological_process sister chromatid biorientation;GO:0031175,biological_process neuron projection development;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0034088,biological_process maintenance of mitotic sister chromatid cohesion;GO:0034349,biological_process glial cell apoptotic process;GO:0035189,cellular_component Rb-E2F complex;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0042551,biological_process neuron maturation;GO:0042802,molecular_function identical protein binding;GO:0043353,biological_process enucleate erythrocyte differentiation;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043550,biological_process regulation of lipid kinase activity;GO:0045445,biological_process myoblast differentiation;GO:0045651,biological_process positive regulation of macrophage differentiation;GO:0045786,biological_process negative regulation of cell cycle;GO:0045842,biological_process positive regulation of mitotic metaphase/anaphase transition;GO:0045879,biological_process negative regulation of smoothened signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048565,biological_process digestive tract development;GO:0048667,biological_process cell morphogenesis involved in neuron differentiation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050681,molecular_function androgen receptor binding;GO:0051146,biological_process striated muscle cell differentiation;GO:0051219,molecular_function phosphoprotein binding;GO:0051301,biological_process cell division;GO:0051402,biological_process neuron apoptotic process;GO:0051726,biological_process regulation of cell cycle;GO:0061676,molecular_function importin-alpha family protein binding;GO:0071459,biological_process protein localization to chromosome, centromeric region;GO:0071466,biological_process cellular response to xenobiotic stimulus;GO:0071922,biological_process regulation of cohesin loading;GO:0071930,biological_process negative regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0090230,biological_process regulation of centromere complex assembly;GO:0097284,biological_process hepatocyte apoptotic process;GO:0097718,molecular_function disordered domain specific binding;GO:2000134,biological_process negative regulation of G1/S transition of mitotic cell cycle;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding	RB1; retinoblastoma-associated protein; K06618	RB transcriptional corepressor 1 [Source:HGNC Symbol%3BAcc:HGNC:9884]
ENSG00000122482	12.26	10.63	11.61	11.21	11.83	11.60	0.0105037982332848	5.52723790667006	0.919275150194557	0.989919618142484	1:90915297-91022272:-	ZNF644	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 644 [Source:HGNC Symbol%3BAcc:HGNC:29222]
ENSG00000058866	0.30	0.32	0.50	0.57	0.16	0.47	-0.0917557535625203	0.106242185995141	0.919421698309625	0.989919618142484	3:186105667-186362237:-	DGKG	21;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030168,biological_process platelet activation;GO:0035556,biological_process intracellular signal transduction;GO:0046486,biological_process glycerolipid metabolic process;GO:0046834,biological_process lipid phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048666,biological_process neuron development	dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]; K00901	diacylglycerol kinase gamma [Source:HGNC Symbol%3BAcc:HGNC:2853]
ENSG00000160124	37.88	41.72	33.66	37.05	39.42	38.30	-0.0149412031500651	4.20140538050831	0.919474663641495	0.989919618142484	3:122359590-122383231:-	CCDC58	1;GO:0005739,cellular_component mitochondrion	NA	coiled-coil domain containing 58 [Source:HGNC Symbol%3BAcc:HGNC:31136]
ENSG00000108799	12.83	11.90	13.96	12.53	13.16	13.12	0.0119677709521253	4.8657320012982	0.919512659478896	0.989919618142484	17:42700274-42745049:-	EZH1	15;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0009653,biological_process anatomical structure morphogenesis;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0021766,biological_process hippocampus development;GO:0032259,biological_process methylation;GO:0035098,cellular_component ESC/E(Z) complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070734,biological_process histone H3-K27 methylation	EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]; K17451	enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:HGNC Symbol%3BAcc:HGNC:3526]
ENSG00000141380	20.59	19.36	21.23	20.90	20.33	20.89	-0.00682644355463565	5.06517673943221	0.91962008683866	0.989919618142484	18:26016252-26091217:-	SS18	17;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000902,biological_process cell morphogenesis;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007010,biological_process cytoskeleton organization;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0035556,biological_process intracellular signal transduction;GO:0042493,biological_process response to drug;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0071564,cellular_component npBAF complex;GO:0097150,biological_process neuronal stem cell population maintenance;GO:1903506,biological_process regulation of nucleic acid-templated transcription	SS18, SSXT, SYT; protein SSXT; K15623	SS18%2C nBAF chromatin remodeling complex subunit [Source:HGNC Symbol%3BAcc:HGNC:11340]
ENSG00000110931	10.71	10.78	10.29	10.93	10.07	11.24	-0.0110515117575601	4.39673605020016	0.919666227352397	0.989919618142484	12:121237690-121298308:-	CAMKK2	30;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005509,molecular_function calcium ion binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019722,biological_process calcium-mediated signaling;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0042995,cellular_component cell projection;GO:0045859,biological_process regulation of protein kinase activity;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046777,biological_process protein autophosphorylation;GO:0061762,biological_process CAMKK-AMPK signaling cascade;GO:1903599,biological_process positive regulation of mitophagy	CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]; K07359	calcium/calmodulin dependent protein kinase kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:1470]
ENSG00000079462	48.10	52.68	43.54	44.51	50.12	49.62	0.00703187871240728	5.06369237412465	0.919834248772326	0.989919618142484	19:42297032-42303546:-	PAFAH1B3	16;GO:0003847,molecular_function 1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0007283,biological_process spermatogenesis;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0047179,molecular_function platelet-activating factor acetyltransferase activity;GO:0070062,cellular_component extracellular exosome	PAFAH1B2_3; platelet-activating factor acetylhydrolase IB subunit beta/gamma [EC:3.1.1.47]; K16795	platelet activating factor acetylhydrolase 1b catalytic subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:8576]
ENSG00000151465	80.08	86.56	75.79	83.19	81.26	80.99	-0.00864848763288526	6.3594285369642	0.919880279613093	0.989919618142484	10:12195964-12250589:+	CDC123	8;GO:0005737,cellular_component cytoplasm;GO:0006417,biological_process regulation of translation;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008284,biological_process positive regulation of cell proliferation;GO:0045948,biological_process positive regulation of translational initiation;GO:0051301,biological_process cell division;GO:1905143,biological_process eukaryotic translation initiation factor 2 complex assembly	NA	cell division cycle 123 [Source:HGNC Symbol%3BAcc:HGNC:16827]
ENSG00000115268	921.91	911.33	845.27	891.49	873.23	924.08	0.0061331098671208	9.02045100012512	0.919956107689108	0.989919618142484	19:1438357-1440494:+	RPS15	23;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000056,biological_process ribosomal small subunit export from nucleus;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001649,biological_process osteoblast differentiation;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042274,biological_process ribosomal small subunit biogenesis	RP-S15e, RPS15; small subunit ribosomal protein S15e; K02958	ribosomal protein S15 [Source:HGNC Symbol%3BAcc:HGNC:10388]
ENSG00000235109	11.57	11.54	9.88	9.40	13.22	10.29	0.014737605252671	3.79408566176665	0.920095047780178	0.989919618142484	6:28324692-28356271:-	ZSCAN31	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger and SCAN domain containing 31 [Source:HGNC Symbol%3BAcc:HGNC:14097]
ENSG00000182141	3.14	4.03	3.31	2.95	4.34	3.40	-0.0268407621939964	2.69366840261097	0.920291607448685	0.989919618142484	19:21291159-21329425:-	ZNF708	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 708 [Source:HGNC Symbol%3BAcc:HGNC:12945]
ENSG00000172795	7.76	7.21	8.18	8.38	6.59	8.67	-0.0157065680134811	3.55649388025518	0.920292768960128	0.989919618142484	5:112976701-113020970:+	DCP2	25;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0004534,molecular_function 5'-3' exoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006402,biological_process mRNA catabolic process;GO:0016442,cellular_component RISC complex;GO:0016787,molecular_function hydrolase activity;GO:0016896,molecular_function exoribonuclease activity, producing 5'-phosphomonoesters;GO:0030054,cellular_component cell junction;GO:0030145,molecular_function manganese ion binding;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0046872,molecular_function metal ion binding;GO:0050072,molecular_function m7G(5')pppN diphosphatase activity;GO:0070034,molecular_function telomerase RNA binding;GO:0071044,biological_process histone mRNA catabolic process;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic;GO:1904872,biological_process regulation of telomerase RNA localization to Cajal body	DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]; K12613	decapping mRNA 2 [Source:HGNC Symbol%3BAcc:HGNC:24452]
ENSG00000081189	2.36	2.23	2.46	1.80	2.39	2.80	0.0267284442940027	1.95387107819683	0.920327048343645	0.989919618142484	5:88717116-88904257:-	MEF2C	136;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000165,biological_process MAPK cascade;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000980,molecular_function RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001568,biological_process blood vessel development;GO:0001649,biological_process osteoblast differentiation;GO:0001764,biological_process neuron migration;GO:0001782,biological_process B cell homeostasis;GO:0001947,biological_process heart looping;GO:0001958,biological_process endochondral ossification;GO:0001974,biological_process blood vessel remodeling;GO:0002062,biological_process chondrocyte differentiation;GO:0002467,biological_process germinal center formation;GO:0002634,biological_process regulation of germinal center formation;GO:0002931,biological_process response to ischemia;GO:0003138,biological_process primary heart field specification;GO:0003139,biological_process secondary heart field specification;GO:0003151,biological_process outflow tract morphogenesis;GO:0003185,biological_process sinoatrial valve morphogenesis;GO:0003211,biological_process cardiac ventricle formation;GO:0003677,molecular_function DNA binding;GO:0003680,molecular_function AT DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006915,biological_process apoptotic process;GO:0006959,biological_process humoral immune response;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007507,biological_process heart development;GO:0007517,biological_process muscle organ development;GO:0007519,biological_process skeletal muscle tissue development;GO:0007521,biological_process muscle cell fate determination;GO:0007611,biological_process learning or memory;GO:0009615,biological_process response to virus;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010694,biological_process positive regulation of alkaline phosphatase activity;GO:0014033,biological_process neural crest cell differentiation;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0014902,biological_process myotube differentiation;GO:0016607,cellular_component nuclear speck;GO:0021542,biological_process dentate gyrus development;GO:0030154,biological_process cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0030220,biological_process platelet formation;GO:0030224,biological_process monocyte differentiation;GO:0030279,biological_process negative regulation of ossification;GO:0030318,biological_process melanocyte differentiation;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0031667,biological_process response to nutrient levels;GO:0033197,biological_process response to vitamin E;GO:0033613,molecular_function activating transcription factor binding;GO:0035198,molecular_function miRNA binding;GO:0035690,biological_process cellular response to drug;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0035984,biological_process cellular response to trichostatin A;GO:0042100,biological_process B cell proliferation;GO:0042826,molecular_function histone deacetylase binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045165,biological_process cell fate commitment;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045663,biological_process positive regulation of myoblast differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046928,biological_process regulation of neurotransmitter secretion;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048643,biological_process positive regulation of skeletal muscle tissue development;GO:0048666,biological_process neuron development;GO:0048667,biological_process cell morphogenesis involved in neuron differentiation;GO:0048703,biological_process embryonic viscerocranium morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051145,biological_process smooth muscle cell differentiation;GO:0051149,biological_process positive regulation of muscle cell differentiation;GO:0051963,biological_process regulation of synapse assembly;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055012,biological_process ventricular cardiac muscle cell differentiation;GO:0060021,biological_process palate development;GO:0060025,biological_process regulation of synaptic activity;GO:0060045,biological_process positive regulation of cardiac muscle cell proliferation;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060290,biological_process transdifferentiation;GO:0060297,biological_process regulation of sarcomere organization;GO:0060536,biological_process cartilage morphogenesis;GO:0060998,biological_process regulation of dendritic spine development;GO:0061333,biological_process renal tubule morphogenesis;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071277,biological_process cellular response to calcium ion;GO:0071300,biological_process cellular response to retinoic acid;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071374,biological_process cellular response to parathyroid hormone stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071498,biological_process cellular response to fluid shear stress;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0071837,molecular_function HMG box domain binding;GO:0071864,biological_process positive regulation of cell proliferation in bone marrow;GO:0072102,biological_process glomerulus morphogenesis;GO:0072160,biological_process nephron tubule epithelial cell differentiation;GO:0090073,biological_process positive regulation of protein homodimerization activity;GO:0098794,cellular_component postsynapse;GO:2000111,biological_process positive regulation of macrophage apoptotic process;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:2000727,biological_process positive regulation of cardiac muscle cell differentiation;GO:2000987,biological_process positive regulation of behavioral fear response;GO:2001013,biological_process epithelial cell proliferation involved in renal tubule morphogenesis;GO:2001016,biological_process positive regulation of skeletal muscle cell differentiation	MEF2C; MADS-box transcription enhancer factor 2C; K04454	myocyte enhancer factor 2C [Source:HGNC Symbol%3BAcc:HGNC:6996]
ENSG00000278259	18.49	20.90	20.57	20.39	19.30	21.02	-0.00924932249047203	5.97873723939288	0.920354634571551	0.989919618142484	17:36495632-36543435:-	MYO19	15;GO:0000166,molecular_function nucleotide binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005856,cellular_component cytoskeleton;GO:0016020,cellular_component membrane;GO:0016459,cellular_component myosin complex;GO:0016887,molecular_function ATPase activity;GO:0032027,molecular_function myosin light chain binding;GO:0032465,biological_process regulation of cytokinesis;GO:0060002,molecular_function plus-end directed microfilament motor activity;GO:0090140,biological_process regulation of mitochondrial fission	NA	myosin XIX [Source:HGNC Symbol%3BAcc:HGNC:26234]
ENSG00000145685	11.87	12.85	9.90	12.04	12.20	11.00	-0.0215222725019526	3.01624370221698	0.920361450569897	0.989919618142484	5:78485214-78770021:-	LHFPL2	8;GO:0002576,biological_process platelet degranulation;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031092,cellular_component platelet alpha granule membrane	NA	LHFPL tetraspan subfamily member 2 [Source:HGNC Symbol%3BAcc:HGNC:6588]
ENSG00000149532	40.34	40.15	45.30	42.53	41.38	43.63	-0.00692373478833626	6.08464749442427	0.920397585395556	0.989919618142484	11:61402640-61430031:-	CPSF7	12;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005849,cellular_component mRNA cleavage factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0016020,cellular_component membrane;GO:0031124,biological_process mRNA 3'-end processing;GO:0051262,biological_process protein tetramerization	CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7; K14398	cleavage and polyadenylation specific factor 7 [Source:HGNC Symbol%3BAcc:HGNC:30098]
ENSG00000183011	38.77	42.62	36.05	41.10	39.84	36.35	0.00853712971376815	4.54039150102287	0.920467743308492	0.989919618142484	17:7856684-7885238:-	NAA38	6;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0031417,cellular_component NatC complex;GO:0043066,biological_process negative regulation of apoptotic process	NA	N(alpha)-acetyltransferase 38%2C NatC auxiliary subunit [Source:HGNC Symbol%3BAcc:HGNC:28212]
ENSG00000196396	40.21	41.16	42.81	43.95	42.89	37.66	0.00873402097560553	5.76180819475143	0.920560393425518	0.989919618142484	20:50510320-50585241:+	PTPN1	54;GO:0003723,molecular_function RNA binding;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005158,molecular_function insulin receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0006987,biological_process activation of signaling protein activity involved in unfolded protein response;GO:0007257,biological_process activation of JUN kinase activity;GO:0008270,molecular_function zinc ion binding;GO:0008286,biological_process insulin receptor signaling pathway;GO:0009966,biological_process regulation of signal transduction;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0030100,biological_process regulation of endocytosis;GO:0030948,biological_process negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0033157,biological_process regulation of intracellular protein transport;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035791,biological_process platelet-derived growth factor receptor-beta signaling pathway;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0045296,molecular_function cadherin binding;GO:0046626,biological_process regulation of insulin receptor signaling pathway;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046875,molecular_function ephrin receptor binding;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0060397,biological_process JAK-STAT cascade involved in growth hormone signaling pathway;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0097443,cellular_component sorting endosome;GO:0098554,cellular_component cytoplasmic side of endoplasmic reticulum membrane;GO:1902202,biological_process regulation of hepatocyte growth factor receptor signaling pathway;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903896,biological_process positive regulation of IRE1-mediated unfolded protein response;GO:1903898,biological_process negative regulation of PERK-mediated unfolded protein response;GO:1990264,biological_process peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:2000646,biological_process positive regulation of receptor catabolic process	PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1 [EC:3.1.3.48]; K05696	protein tyrosine phosphatase%2C non-receptor type 1 [Source:HGNC Symbol%3BAcc:HGNC:9642]
ENSG00000125733	91.50	87.35	91.91	95.44	84.52	94.35	-0.00664069442987756	7.48306768028817	0.920684010008333	0.989919618142484	19:6737924-6751526:+	TRIP10	25;GO:0001891,cellular_component phagocytic cup;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006897,biological_process endocytosis;GO:0007154,biological_process cell communication;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0030036,biological_process actin cytoskeleton organization;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome	TRIP10, CIP4; thyroid hormone receptor interactor 10; K07196	thyroid hormone receptor interactor 10 [Source:HGNC Symbol%3BAcc:HGNC:12304]
ENSG00000122778	4.65	5.51	4.24	4.42	5.63	4.32	0.0108100958310863	4.81222008846722	0.920742193782704	0.989919618142484	7:138831380-138981318:-	KIAA1549	3;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	KIAA1549 [Source:HGNC Symbol%3BAcc:HGNC:22219]
ENSG00000130303	239.74	239.27	226.26	230.02	236.24	247.94	-0.00698961449215277	6.99970681985819	0.920745791306869	0.989919618142484	19:17402938-17405648:-	BST2	43;GO:0002376,biological_process immune system process;GO:0002737,biological_process negative regulation of plasmacytoid dendritic cell cytokine production;GO:0003723,molecular_function RNA binding;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005771,cellular_component multivesicular body;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006959,biological_process humoral immune response;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0008191,molecular_function metalloendopeptidase inhibitor activity;GO:0008283,biological_process cell proliferation;GO:0009615,biological_process response to virus;GO:0009986,cellular_component cell surface;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030308,biological_process negative regulation of cell growth;GO:0030336,biological_process negative regulation of cell migration;GO:0031225,cellular_component anchored component of membrane;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0034341,biological_process response to interferon-gamma;GO:0035455,biological_process response to interferon-alpha;GO:0035456,biological_process response to interferon-beta;GO:0035577,cellular_component azurophil granule membrane;GO:0042113,biological_process B cell activation;GO:0042803,molecular_function protein homodimerization activity;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043312,biological_process neutrophil degranulation;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045121,cellular_component membrane raft;GO:0051607,biological_process defense response to virus;GO:0060337,biological_process type I interferon signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:1901253,biological_process negative regulation of intracellular transport of viral material	BST2, CD317; bone marrow stromal cell antigen 2; K06731	bone marrow stromal cell antigen 2 [Source:HGNC Symbol%3BAcc:HGNC:1119]
ENSG00000185127	18.61	19.01	17.47	14.37	20.65	19.88	0.0138498630256032	3.41343553891151	0.920970495106098	0.989919618142484	6:169702189-169704856:+	C6orf120	5;GO:0005576,cellular_component extracellular region;GO:0006915,biological_process apoptotic process;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	NA	chromosome 6 open reading frame 120 [Source:HGNC Symbol%3BAcc:HGNC:21247]
ENSG00000167103	1.08	0.57	0.93	0.76	0.83	1.19	-0.069406115397783	0.296080982449257	0.921025082364666	0.989919618142484	9:127920878-127930797:-	PIP5KL1	13;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016307,molecular_function phosphatidylinositol phosphate kinase activity;GO:0016308,molecular_function 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0042995,cellular_component cell projection;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation	PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase-like protein 1 [EC:2.7.1.68]; K13712	phosphatidylinositol-4-phosphate 5-kinase like 1 [Source:HGNC Symbol%3BAcc:HGNC:28711]
ENSG00000071462	96.85	95.47	94.82	95.02	95.44	100.36	-0.00670254120516829	6.64550356390189	0.921135530397837	0.989919618142484	7:73683024-73705161:+	BUD23	19;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016435,molecular_function rRNA (guanine) methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0042254,biological_process ribosome biogenesis;GO:0070476,biological_process rRNA (guanine-N7)-methylation	NA	BUD23%2C rRNA methyltransferase and ribosome maturation factor [Source:HGNC Symbol%3BAcc:HGNC:16405]
ENSG00000173706	13.09	14.09	12.46	14.38	13.33	12.44	-0.00935479275873875	5.79483723155816	0.921217971118653	0.989919618142484	3:124965709-125055958:-	HEG1	32;GO:0001570,biological_process vasculogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001885,biological_process endothelial cell development;GO:0001886,biological_process endothelial cell morphogenesis;GO:0001944,biological_process vasculature development;GO:0001945,biological_process lymph vessel development;GO:0003017,biological_process lymph circulation;GO:0003209,biological_process cardiac atrium morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003281,biological_process ventricular septum development;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0007043,biological_process cell-cell junction assembly;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0009791,biological_process post-embryonic development;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030324,biological_process lung development;GO:0035264,biological_process multicellular organism growth;GO:0045216,biological_process cell-cell junction organization;GO:0048845,biological_process venous blood vessel morphogenesis;GO:0050878,biological_process regulation of body fluid levels;GO:0055017,biological_process cardiac muscle tissue growth;GO:0060039,biological_process pericardium development;GO:0090271,biological_process positive regulation of fibroblast growth factor production	NA	heart development protein with EGF like domains 1 [Source:HGNC Symbol%3BAcc:HGNC:29227]
ENSG00000152763	4.72	4.25	4.12	3.92	4.36	5.05	-0.01373709779321	3.63813940579918	0.92122198513939	0.989919618142484	1:66812884-66924887:-	WDR78	6;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003341,biological_process cilium movement;GO:0005858,cellular_component axonemal dynein complex;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0045503,molecular_function dynein light chain binding;GO:0045504,molecular_function dynein heavy chain binding	NA	WD repeat domain 78 [Source:HGNC Symbol%3BAcc:HGNC:26252]
ENSG00000100036	3.61	2.64	3.57	2.94	3.11	3.71	0.035487986634316	2.03086461706608	0.9212248383512	0.989919618142484	22:30635651-30669016:+	SLC35E4	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member E4 [Source:HGNC Symbol%3BAcc:HGNC:17058]
ENSG00000182257	3.41	2.54	1.07	1.63	3.11	1.87	0.101062199679239	0.123633815494141	0.921330638794956	0.989919618142484	22:46049477-46054144:-	PRR34	NA	NA	proline rich 34 [Source:HGNC Symbol%3BAcc:HGNC:25606]
ENSG00000131943	9.18	11.85	15.16	11.68	12.13	13.36	-0.0292178723287797	2.64856066746942	0.921335805075334	0.989919618142484	19:29698885-29715789:-	C19orf12	11;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006979,biological_process response to oxidative stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0051560,biological_process mitochondrial calcium ion homeostasis	NA	chromosome 19 open reading frame 12 [Source:HGNC Symbol%3BAcc:HGNC:25443]
ENSG00000164951	67.40	63.03	62.73	63.86	65.41	64.65	0.00698784972648051	6.76831406876205	0.921512159007324	0.989961261181062	8:93857806-93926066:+	PDP1	13;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004741,molecular_function [pyruvate dehydrogenase (lipoamide)] phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006470,biological_process protein dephosphorylation;GO:0010510,biological_process regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0016787,molecular_function hydrolase activity;GO:0035970,biological_process peptidyl-threonine dephosphorylation;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding	NA	pyruvate dehyrogenase phosphatase catalytic subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:9279]
ENSG00000123643	1.79	2.80	2.54	2.39	2.57	2.06	0.019527342084122	1.90371106505232	0.921534066941688	0.989961261181062	5:151437045-151492381:+	SLC36A1	26;GO:0003333,biological_process amino acid transmembrane transport;GO:0005280,molecular_function hydrogen:amino acid symporter activity;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006865,biological_process amino acid transport;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015175,molecular_function neutral amino acid transmembrane transporter activity;GO:0015180,molecular_function L-alanine transmembrane transporter activity;GO:0015187,molecular_function glycine transmembrane transporter activity;GO:0015193,molecular_function L-proline transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015804,biological_process neutral amino acid transport;GO:0015808,biological_process L-alanine transport;GO:0015816,biological_process glycine transport;GO:0015824,biological_process proline transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035524,biological_process proline transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:1902600,biological_process hydrogen ion transmembrane transport	SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter); K14209	solute carrier family 36 member 1 [Source:HGNC Symbol%3BAcc:HGNC:18761]
ENSG00000198912	24.22	28.58	24.23	26.40	26.53	23.92	0.00752905997181448	4.23219180613846	0.921770375863165	0.990129428486454	1:3889124-3900293:-	C1orf174	2;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	chromosome 1 open reading frame 174 [Source:HGNC Symbol%3BAcc:HGNC:27915]
ENSG00000181467	34.22	29.24	35.53	34.78	29.98	34.45	0.0156896194913384	4.19814484252383	0.92191093310358	0.990163931128298	3:153162269-153170620:+	RAP2B	26;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0019003,molecular_function GDP binding;GO:0019904,molecular_function protein domain specific binding;GO:0030168,biological_process platelet activation;GO:0030336,biological_process negative regulation of cell migration;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032486,biological_process Rap protein signal transduction;GO:0035579,cellular_component specific granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0044291,cellular_component cell-cell contact zone;GO:0045121,cellular_component membrane raft;GO:0055037,cellular_component recycling endosome;GO:0055038,cellular_component recycling endosome membrane;GO:0061097,biological_process regulation of protein tyrosine kinase activity;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0070821,cellular_component tertiary granule membrane	NA	RAP2B%2C member of RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:9862]
ENSG00000167695	14.69	18.05	15.24	17.35	15.15	15.27	0.0089849835391087	4.13651734717079	0.922015422431836	0.990163931128298	17:732411-742972:+	FAM57A	5;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 57 member A [Source:HGNC Symbol%3BAcc:HGNC:29646]
ENSG00000177954	1137.60	956.51	1084.68	1091.12	984.37	1113.34	0.00780602479717697	8.47574730679902	0.922101929888076	0.990163931128298	1:153990758-153992150:+	RPS27	22;GO:0000028,biological_process ribosomal small subunit assembly;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0007062,biological_process sister chromatid cohesion;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0046872,molecular_function metal ion binding	RP-S27e, RPS27; small subunit ribosomal protein S27e; K02978	ribosomal protein S27 [Source:HGNC Symbol%3BAcc:HGNC:10416]
ENSG00000171793	13.94	14.55	15.82	15.46	16.00	13.56	-0.00939148828823282	4.73097921326556	0.92212156963209	0.990163931128298	1:40979334-41012565:+	CTPS1	17;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003883,molecular_function CTP synthase activity;GO:0005524,molecular_function ATP binding;GO:0005829,cellular_component cytosol;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006221,biological_process pyrimidine nucleotide biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0006541,biological_process glutamine metabolic process;GO:0015949,biological_process nucleobase-containing small molecule interconversion;GO:0016020,cellular_component membrane;GO:0016874,molecular_function ligase activity;GO:0042098,biological_process T cell proliferation;GO:0042100,biological_process B cell proliferation;GO:0042493,biological_process response to drug;GO:0042802,molecular_function identical protein binding;GO:0044210,biological_process 'de novo' CTP biosynthetic process	pyrG, CTPS; CTP synthase [EC:6.3.4.2]; K01937	CTP synthase 1 [Source:HGNC Symbol%3BAcc:HGNC:2519]
ENSG00000076242	21.60	22.32	20.33	21.56	19.76	23.03	0.00647405635525847	5.62754108460464	0.922274209725917	0.990242173283263	3:36993331-37050918:+	MLH1	47;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000712,biological_process resolution of meiotic recombination intermediates;GO:0000793,cellular_component condensed chromosome;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000795,cellular_component synaptonemal complex;GO:0001673,cellular_component male germ cell nucleus;GO:0002204,biological_process somatic recombination of immunoglobulin genes involved in immune response;GO:0003682,molecular_function chromatin binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005712,cellular_component chiasma;GO:0005715,cellular_component late recombination nodule;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0007060,biological_process male meiosis chromosome segregation;GO:0007129,biological_process synapsis;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007140,biological_process male meiosis;GO:0007283,biological_process spermatogenesis;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016020,cellular_component membrane;GO:0016321,biological_process female meiosis chromosome segregation;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016447,biological_process somatic recombination of immunoglobulin gene segments;GO:0016887,molecular_function ATPase activity;GO:0030983,molecular_function mismatched DNA binding;GO:0032137,molecular_function guanine/thymine mispair binding;GO:0032389,cellular_component MutLalpha complex;GO:0032407,molecular_function MutSalpha complex binding;GO:0043060,biological_process meiotic metaphase I plate congression;GO:0045132,biological_process meiotic chromosome segregation;GO:0045141,biological_process meiotic telomere clustering;GO:0045143,biological_process homologous chromosome segregation;GO:0045190,biological_process isotype switching;GO:0045950,biological_process negative regulation of mitotic recombination;GO:0048298,biological_process positive regulation of isotype switching to IgA isotypes;GO:0048304,biological_process positive regulation of isotype switching to IgG isotypes;GO:0048477,biological_process oogenesis;GO:0051257,biological_process meiotic spindle midzone assembly;GO:0051321,biological_process meiotic cell cycle	MLH1; DNA mismatch repair protein MLH1; K08734	mutL homolog 1 [Source:HGNC Symbol%3BAcc:HGNC:7127]
ENSG00000198554	9.34	10.69	8.56	9.46	9.18	9.92	0.00599498149198821	5.01648757238776	0.922555576716094	0.990258324632657	14:54938949-55027105:-	WDHD1	5;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm	NA	WD repeat and HMG-box DNA binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:23170]
ENSG00000160917	25.85	26.30	26.47	25.26	23.90	29.52	0.00857355891438057	4.83133923355643	0.922572362220898	0.990258324632657	7:99438921-99457371:+	CPSF4	21;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004521,molecular_function endoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006378,biological_process mRNA polyadenylation;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0006406,biological_process mRNA export from nucleus;GO:0008270,molecular_function zinc ion binding;GO:0016032,biological_process viral process;GO:0031124,biological_process mRNA 3'-end processing;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046778,biological_process modification by virus of host mRNA processing;GO:0046872,molecular_function metal ion binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0098789,biological_process pre-mRNA cleavage required for polyadenylation	CPSF4, YTH1; cleavage and polyadenylation specificity factor subunit 4; K14404	cleavage and polyadenylation specific factor 4 [Source:HGNC Symbol%3BAcc:HGNC:2327]
ENSG00000186272	3.69	3.48	4.32	3.87	3.43	4.16	0.0190030083861595	3.06868857853019	0.922643396281872	0.990258324632657	19:57411162-57421939:+	ZNF17	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 17 [Source:HGNC Symbol%3BAcc:HGNC:12958]
ENSG00000159714	6.84	7.61	8.30	8.54	6.67	7.93	-0.0148500955969165	3.60427499837422	0.922694756572748	0.990258324632657	16:67394418-67416833:-	ZDHHC1	10;GO:0003677,molecular_function DNA binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0070062,cellular_component extracellular exosome	NA	zinc finger DHHC-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17916]
ENSG00000196597	2.03	1.80	2.24	1.98	2.01	2.05	0.0302873007395484	2.22390032307516	0.922720726513073	0.990258324632657	9:96816471-96875623:-	ZNF782	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 782 [Source:HGNC Symbol%3BAcc:HGNC:33110]
ENSG00000166446	0.69	0.56	1.01	0.74	0.75	0.74	0.0688457243705935	0.38327095149173	0.92278690702081	0.990258324632657	16:80597905-80804329:-	CDYL2	5;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0008152,biological_process metabolic process;GO:0035064,molecular_function methylated histone binding	NA	chromodomain Y like 2 [Source:HGNC Symbol%3BAcc:HGNC:23030]
ENSG00000160957	8.92	9.42	7.60	8.74	9.45	7.74	0.00948138284116066	4.9848349976372	0.922891369286407	0.990258324632657	8:144511287-144517845:-	RECQL4	4;GO:0003676,molecular_function nucleic acid binding;GO:0005524,molecular_function ATP binding;GO:0006310,biological_process DNA recombination;GO:0008026,molecular_function ATP-dependent helicase activity	NA	RecQ like helicase 4 [Source:HGNC Symbol%3BAcc:HGNC:9949]
ENSG00000165688	33.22	36.30	31.37	33.24	35.55	33.34	-0.00917103120884253	5.97556121779101	0.922984249446258	0.990258324632657	9:136410569-136423761:+	PMPCA	15;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005759,cellular_component mitochondrial matrix;GO:0006508,biological_process proteolysis;GO:0006627,biological_process protein processing involved in protein targeting to mitochondrion;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding	NA	peptidase%2C mitochondrial processing alpha subunit [Source:HGNC Symbol%3BAcc:HGNC:18667]
ENSG00000159322	25.82	27.45	26.67	25.56	28.31	26.25	0.00690848975608555	5.39338703112411	0.923042536797849	0.990258324632657	15:72751368-72785846:-	ADPGK	15;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006006,biological_process glucose metabolic process;GO:0006096,biological_process glycolytic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0043843,molecular_function ADP-specific glucokinase activity;GO:0046872,molecular_function metal ion binding;GO:0061621,biological_process canonical glycolysis	ADPGK; ADP-dependent glucokinase [EC:2.7.1.147]; K08074	ADP dependent glucokinase [Source:HGNC Symbol%3BAcc:HGNC:25250]
ENSG00000088836	0.39	0.36	0.23	0.26	0.58	0.19	-0.0504957848687321	0.15713464689544	0.923425684313955	0.990258324632657	20:3227416-3239190:-	SLC4A11	30;GO:0005215,molecular_function transporter activity;GO:0005272,molecular_function sodium channel activity;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0006820,biological_process anion transport;GO:0015106,molecular_function bicarbonate transmembrane transporter activity;GO:0015252,molecular_function hydrogen ion channel activity;GO:0015293,molecular_function symporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015698,biological_process inorganic anion transport;GO:0015701,biological_process bicarbonate transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0030003,biological_process cellular cation homeostasis;GO:0035445,biological_process borate transmembrane transport;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042044,biological_process fluid transport;GO:0046713,biological_process borate transport;GO:0046715,molecular_function borate transmembrane transporter activity;GO:0046983,molecular_function protein dimerization activity;GO:0050801,biological_process ion homeostasis;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	solute carrier family 4 member 11 [Source:HGNC Symbol%3BAcc:HGNC:16438]
ENSG00000015153	13.62	9.03	10.82	12.98	8.71	11.71	0.022859461541092	3.54634580346385	0.923468984939688	0.990258324632657	12:42157103-42238349:-	YAF2	11;GO:0003713,molecular_function transcription coactivator activity;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	YY1 associated factor 2 [Source:HGNC Symbol%3BAcc:HGNC:17363]
ENSG00000254986	12.91	15.61	12.83	12.07	16.70	12.51	0.0109682961410339	4.96989527242808	0.92349866189457	0.990258324632657	11:66480012-66509657:+	DPP3	14;GO:0004177,molecular_function aminopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008239,molecular_function dipeptidyl-peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016607,cellular_component nuclear speck;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	dipeptidyl peptidase 3 [Source:HGNC Symbol%3BAcc:HGNC:3008]
ENSG00000198087	47.60	46.66	44.00	46.83	44.43	47.47	0.006330912459153	6.47086794407568	0.923547369023391	0.990258324632657	6:47477788-47627263:+	CD2AP	35;GO:0001726,cellular_component ruffle;GO:0005172,molecular_function vascular endothelial growth factor receptor binding;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006461,biological_process protein complex assembly;GO:0006930,biological_process substrate-dependent cell migration, cell extension;GO:0007010,biological_process cytoskeleton organization;GO:0007049,biological_process cell cycle;GO:0007165,biological_process signal transduction;GO:0008013,molecular_function beta-catenin binding;GO:0008022,molecular_function protein C-terminus binding;GO:0015629,cellular_component actin cytoskeleton;GO:0016050,biological_process vesicle organization;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016477,biological_process cell migration;GO:0017124,molecular_function SH3 domain binding;GO:0030139,cellular_component endocytic vesicle;GO:0031252,cellular_component cell leading edge;GO:0031941,cellular_component filamentous actin;GO:0032403,molecular_function protein complex binding;GO:0032911,biological_process negative regulation of transforming growth factor beta1 production;GO:0042995,cellular_component cell projection;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043234,cellular_component protein complex;GO:0045296,molecular_function cadherin binding;GO:0048259,biological_process regulation of receptor-mediated endocytosis;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0070062,cellular_component extracellular exosome;GO:1900182,biological_process positive regulation of protein localization to nucleus;GO:2000249,biological_process regulation of actin cytoskeleton reorganization	CD2AP; CD2-associated protein; K13738	CD2 associated protein [Source:HGNC Symbol%3BAcc:HGNC:14258]
ENSG00000120868	6.66	5.83	5.05	5.98	5.74	6.12	-0.0119247808398841	4.49941713759329	0.923572667330672	0.990258324632657	12:98645140-98735433:+	APAF1	42;GO:0000166,molecular_function nucleotide binding;GO:0001666,biological_process response to hypoxia;GO:0001843,biological_process neural tube closure;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007420,biological_process brain development;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0008635,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0008656,molecular_function cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0010659,biological_process cardiac muscle cell apoptotic process;GO:0030154,biological_process cell differentiation;GO:0030900,biological_process forebrain development;GO:0031072,molecular_function heat shock protein binding;GO:0034349,biological_process glial cell apoptotic process;GO:0034774,cellular_component secretory granule lumen;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043293,cellular_component apoptosome;GO:0043312,biological_process neutrophil degranulation;GO:0043531,molecular_function ADP binding;GO:0051260,biological_process protein homooligomerization;GO:0051402,biological_process neuron apoptotic process;GO:0070059,biological_process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070062,cellular_component extracellular exosome;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0072432,biological_process response to G1 DNA damage checkpoint signaling;GO:0097190,biological_process apoptotic signaling pathway;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1902510,biological_process regulation of apoptotic DNA fragmentation;GO:1904813,cellular_component ficolin-1-rich granule lumen;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	APAF1; apoptotic protease-activating factor; K02084	apoptotic peptidase activating factor 1 [Source:HGNC Symbol%3BAcc:HGNC:576]
ENSG00000075223	29.89	23.86	27.72	29.10	22.83	29.70	0.0114138419878228	5.997658383732	0.92364383983409	0.990258324632657	7:80742537-80922359:-	SEMA3C	23;GO:0001755,biological_process neural crest cell migration;GO:0001756,biological_process somitogenesis;GO:0001974,biological_process blood vessel remodeling;GO:0003151,biological_process outflow tract morphogenesis;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0003350,biological_process pulmonary myocardium development;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006955,biological_process immune response;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0007507,biological_process heart development;GO:0009791,biological_process post-embryonic development;GO:0021915,biological_process neural tube development;GO:0030154,biological_process cell differentiation;GO:0030215,molecular_function semaphorin receptor binding;GO:0038191,molecular_function neuropilin binding;GO:0042493,biological_process response to drug;GO:0050919,biological_process negative chemotaxis;GO:0060174,biological_process limb bud formation;GO:0060666,biological_process dichotomous subdivision of terminal units involved in salivary gland branching;GO:0070062,cellular_component extracellular exosome	SEMA3; semaphorin 3; K06840	semaphorin 3C [Source:HGNC Symbol%3BAcc:HGNC:10725]
ENSG00000127511	30.77	26.27	32.06	30.06	30.13	30.19	-0.00610878221123031	6.77577882513205	0.923665283408641	0.990258324632657	19:16829399-16880353:+	SIN3B	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000805,cellular_component X chromosome;GO:0000806,cellular_component Y chromosome;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0001741,cellular_component XY body;GO:0003682,molecular_function chromatin binding;GO:0003714,molecular_function transcription corepressor activity;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016575,biological_process histone deacetylation;GO:0016580,cellular_component Sin3 complex;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030849,cellular_component autosome;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	SIN3 transcription regulator family member B [Source:HGNC Symbol%3BAcc:HGNC:19354]
ENSG00000129484	24.38	23.92	23.22	24.69	21.58	25.39	0.0076205635840355	5.39046107868009	0.92373639068481	0.990258324632657	14:20343581-20357905:+	PARP2	18;GO:0003677,molecular_function DNA binding;GO:0003910,molecular_function DNA ligase (ATP) activity;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006273,biological_process lagging strand elongation;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006471,biological_process protein ADP-ribosylation;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018312,biological_process peptidyl-serine ADP-ribosylation;GO:0051103,biological_process DNA ligation involved in DNA repair;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:1990404,molecular_function protein ADP-ribosylase activity	PARP; poly [ADP-ribose] polymerase [EC:2.4.2.30]; K10798	poly(ADP-ribose) polymerase 2 [Source:HGNC Symbol%3BAcc:HGNC:272]
ENSG00000196236	9.21	9.63	8.66	9.22	9.76	8.49	0.010947500360635	3.92895430939375	0.923903588318045	0.990258324632657	22:40857076-40932815:+	XPNPEP3	11;GO:0003094,biological_process glomerular filtration;GO:0004177,molecular_function aminopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity;GO:0030145,molecular_function manganese ion binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	X-prolyl aminopeptidase 3 [Source:HGNC Symbol%3BAcc:HGNC:28052]
ENSG00000146540	64.34	58.55	65.58	62.30	61.04	65.88	0.00940695161186281	5.46298683773794	0.923966681227416	0.990258324632657	7:996985-1138260:-	C7orf50	2;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding	NA	chromosome 7 open reading frame 50 [Source:HGNC Symbol%3BAcc:HGNC:22421]
ENSG00000135052	110.02	106.85	103.03	103.56	111.90	105.62	0.00648990620351033	7.00840372093873	0.923980135132603	0.990258324632657	9:86026145-86100173:-	GOLM1	12;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005794,cellular_component Golgi apparatus;GO:0005887,cellular_component integral component of plasma membrane;GO:0006997,biological_process nucleus organization;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019216,biological_process regulation of lipid metabolic process;GO:0043687,biological_process post-translational protein modification;GO:0044267,biological_process cellular protein metabolic process;GO:0070062,cellular_component extracellular exosome	NA	golgi membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:15451]
ENSG00000139117	17.56	18.42	19.51	18.70	18.64	18.28	0.00823376996454369	5.02873821959653	0.924029264559766	0.990258324632657	12:38646821-38907430:-	CPNE8	3;GO:0003674,molecular_function molecular_function;GO:0008150,biological_process biological_process;GO:0070062,cellular_component extracellular exosome	NA	copine 8 [Source:HGNC Symbol%3BAcc:HGNC:23498]
ENSG00000013392	17.90	14.62	14.70	15.47	16.19	16.46	-0.00870621622390581	3.81932296625935	0.924072413769126	0.990258324632657	6:83193378-83198932:+	RWDD2A	NA	NA	RWD domain containing 2A [Source:HGNC Symbol%3BAcc:HGNC:21385]
ENSG00000135686	17.89	17.43	17.92	18.43	17.48	18.07	-0.00743987891151122	5.05362253220579	0.924203203084372	0.990258324632657	16:84648524-84667686:+	KLHL36	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch like family member 36 [Source:HGNC Symbol%3BAcc:HGNC:17844]
ENSG00000132386	3.07	3.20	3.76	2.97	3.23	3.75	0.0220098837330177	2.18058890382817	0.924203874234216	0.990258324632657	17:1761958-1777574:+	SERPINF1	34;GO:0001822,biological_process kidney development;GO:0004867,molecular_function serine-type endopeptidase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0007568,biological_process aging;GO:0007614,biological_process short-term memory;GO:0008283,biological_process cell proliferation;GO:0010447,biological_process response to acidic pH;GO:0010596,biological_process negative regulation of endothelial cell migration;GO:0010629,biological_process negative regulation of gene expression;GO:0010951,biological_process negative regulation of endopeptidase activity;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030424,cellular_component axon;GO:0031012,cellular_component extracellular matrix;GO:0042470,cellular_component melanosome;GO:0042698,biological_process ovulation cycle;GO:0043025,cellular_component neuronal cell body;GO:0043203,cellular_component axon hillock;GO:0046685,biological_process response to arsenic-containing substance;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050769,biological_process positive regulation of neurogenesis;GO:0060041,biological_process retina development in camera-type eye;GO:0060770,biological_process negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0070062,cellular_component extracellular exosome;GO:0071279,biological_process cellular response to cobalt ion;GO:0071300,biological_process cellular response to retinoic acid;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:1901215,biological_process negative regulation of neuron death	NA	serpin family F member 1 [Source:HGNC Symbol%3BAcc:HGNC:8824]
ENSG00000213619	35.60	37.74	32.32	35.38	34.95	35.44	0.00596746067919496	5.29306706478568	0.924440893539934	0.9902740582109	11:47565335-47584562:+	NDUFS3	23;GO:0003954,molecular_function NADH dehydrogenase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005759,cellular_component mitochondrial matrix;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016604,cellular_component nuclear body;GO:0016651,molecular_function oxidoreductase activity, acting on NAD(P)H;GO:0021762,biological_process substantia nigra development;GO:0030308,biological_process negative regulation of cell growth;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0043209,cellular_component myelin sheath;GO:0045333,biological_process cellular respiration;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:0072593,biological_process reactive oxygen species metabolic process;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2 1.6.99.3]; K03936	NADH:ubiquinone oxidoreductase core subunit S3 [Source:HGNC Symbol%3BAcc:HGNC:7710]
ENSG00000144362	5.18	5.68	6.72	4.97	6.50	5.93	0.0268298858273082	2.12774985186273	0.924462195732027	0.9902740582109	2:169694453-169701708:+	PHOSPHO2	6;GO:0005515,molecular_function protein binding;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0033883,molecular_function pyridoxal phosphatase activity;GO:0046872,molecular_function metal ion binding	PHOSPHO2; pyridoxal phosphate phosphatase PHOSPHO2 [EC:3.1.3.74]; K13248	phosphatase%2C orphan 2 [Source:HGNC Symbol%3BAcc:HGNC:28316]
ENSG00000125122	1.37	2.14	1.43	2.35	1.13	1.68	-0.0838804372796168	0.341726711346717	0.9244817149677	0.9902740582109	16:67207138-67227048:-	LRRC29	1;GO:0005515,molecular_function protein binding	NA	leucine rich repeat containing 29 [Source:HGNC Symbol%3BAcc:HGNC:13605]
ENSG00000145241	10.23	9.83	9.66	9.65	10.46	9.69	0.00941001839036093	4.84836009731966	0.924580521183643	0.9902740582109	4:67468747-67545606:-	CENPC	23;GO:0000278,biological_process mitotic cell cycle;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000778,cellular_component condensed nuclear chromosome kinetochore;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005721,cellular_component pericentric heterochromatin;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007062,biological_process sister chromatid cohesion;GO:0016604,cellular_component nuclear body;GO:0019237,molecular_function centromeric DNA binding;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0051301,biological_process cell division;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0051382,biological_process kinetochore assembly;GO:0051455,biological_process attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation	NA	centromere protein C [Source:HGNC Symbol%3BAcc:HGNC:1854]
ENSG00000140743	31.25	33.30	30.19	32.52	32.33	31.06	-0.00913908855231256	5.44108379626849	0.924617444184672	0.9902740582109	16:22345935-22437165:-	CDR2	3;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm	NA	cerebellar degeneration related protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1799]
ENSG00000126934	81.69	84.02	83.60	84.92	82.79	82.51	0.00602367451418108	6.64541124571111	0.924785401659658	0.99031401424198	19:4090320-4124129:-	MAP2K2	49;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005778,cellular_component peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005874,cellular_component microtubule;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030165,molecular_function PDZ domain binding;GO:0032872,biological_process regulation of stress-activated MAPK cascade;GO:0035897,biological_process proteolysis in other organism;GO:0036289,biological_process peptidyl-serine autophosphorylation;GO:0042981,biological_process regulation of apoptotic process;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0090170,biological_process regulation of Golgi inheritance;GO:0097110,molecular_function scaffold protein binding;GO:1903800,biological_process positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:2000641,biological_process regulation of early endosome to late endosome transport	MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]; K04369	mitogen-activated protein kinase kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:6842]
ENSG00000167670	12.69	11.22	10.61	12.38	11.01	11.22	0.0104261356437834	5.08101907864852	0.924814311857974	0.99031401424198	19:4402661-4445018:+	CHAF1A	16;GO:0000790,cellular_component nuclear chromatin;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0006461,biological_process protein complex assembly;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007049,biological_process cell cycle;GO:0031497,biological_process chromatin assembly;GO:0033186,cellular_component CAF-1 complex;GO:0042802,molecular_function identical protein binding;GO:0043234,cellular_component protein complex;GO:0051082,molecular_function unfolded protein binding;GO:0070087,molecular_function chromo shadow domain binding	NA	chromatin assembly factor 1 subunit A [Source:HGNC Symbol%3BAcc:HGNC:1910]
ENSG00000123104	9.48	8.44	8.75	8.77	8.72	9.55	-0.00617906789720173	6.19616492560217	0.925067423589853	0.99049960571214	12:26336514-26833198:-	ITPR2	33;GO:0001666,biological_process response to hypoxia;GO:0005216,molecular_function ion channel activity;GO:0005220,molecular_function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0005262,molecular_function calcium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0007165,biological_process signal transduction;GO:0015085,molecular_function calcium ion transmembrane transporter activity;GO:0015278,molecular_function calcium-release channel activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0030168,biological_process platelet activation;GO:0031095,cellular_component platelet dense tubular network membrane;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0035091,molecular_function phosphatidylinositol binding;GO:0043235,cellular_component receptor complex;GO:0048016,biological_process inositol phosphate-mediated signaling;GO:0050796,biological_process regulation of insulin secretion;GO:0051209,biological_process release of sequestered calcium ion into cytosol;GO:0055085,biological_process transmembrane transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0071320,biological_process cellular response to cAMP;GO:0071361,biological_process cellular response to ethanol;GO:1903779,biological_process regulation of cardiac conduction	ITPR2; inositol 1,4,5-triphosphate receptor type 2; K04959	inositol 1%2C4%2C5-trisphosphate receptor type 2 [Source:HGNC Symbol%3BAcc:HGNC:6181]
ENSG00000180423	3.58	4.20	4.57	3.86	4.85	3.96	-0.0287530263396435	2.17356263886478	0.925503618342324	0.990871607261759	11:46602860-46617909:-	HARBI1	9;GO:0004518,molecular_function nuclease activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	harbinger transposase derived 1 [Source:HGNC Symbol%3BAcc:HGNC:26522]
ENSG00000139163	15.74	19.16	16.50	16.49	18.95	16.64	-0.0137447603157463	4.71829246809424	0.925591100805673	0.990871607261759	12:22625074-22690665:+	ETNK1	16;GO:0000166,molecular_function nucleotide binding;GO:0004305,molecular_function ethanolamine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	ETNK, EKI; ethanolamine kinase [EC:2.7.1.82]; K00894	ethanolamine kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:24649]
ENSG00000132849	12.94	11.89	13.34	12.33	13.21	13.15	-0.00553131185917701	6.23924821148451	0.92565432673869	0.990871607261759	1:61742476-62178675:+	PATJ	16;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030054,cellular_component cell junction;GO:0035556,biological_process intracellular signal transduction;GO:0043234,cellular_component protein complex;GO:0045177,cellular_component apical part of cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0070830,biological_process bicellular tight junction assembly	INADL, PATJ; InaD-like protein; K06092	PATJ%2C crumbs cell polarity complex component [Source:HGNC Symbol%3BAcc:HGNC:28881]
ENSG00000157110	96.48	90.33	101.22	95.75	96.38	97.13	0.00749245069856152	6.57188451402238	0.925844104660456	0.990913674543769	8:30384478-30572261:+	RBPMS	22;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003676,molecular_function nucleic acid binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005685,cellular_component U1 snRNP;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006396,biological_process RNA processing;GO:0006979,biological_process response to oxidative stress;GO:0008143,molecular_function poly(A) binding;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030619,molecular_function U1 snRNA binding;GO:0035614,molecular_function snRNA stem-loop binding;GO:0042803,molecular_function protein homodimerization activity;GO:0060391,biological_process positive regulation of SMAD protein import into nucleus	NA	RNA binding protein with multiple splicing [Source:HGNC Symbol%3BAcc:HGNC:19097]
ENSG00000170027	193.10	183.52	202.43	197.03	184.34	205.26	-0.00614073631008709	7.17251507836726	0.925853282635836	0.990913674543769	7:76326793-76359031:-	YWHAG	28;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003723,molecular_function RNA binding;GO:0005080,molecular_function protein kinase C binding;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006605,biological_process protein targeting;GO:0008426,molecular_function protein kinase C inhibitor activity;GO:0009966,biological_process regulation of signal transduction;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0031982,cellular_component vesicle;GO:0032869,biological_process cellular response to insulin stimulus;GO:0043209,cellular_component myelin sheath;GO:0045664,biological_process regulation of neuron differentiation;GO:0048167,biological_process regulation of synaptic plasticity;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1900740,biological_process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	NA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [Source:HGNC Symbol%3BAcc:HGNC:12852]
ENSG00000169504	368.30	345.75	359.86	346.34	366.52	365.77	0.00593423156158298	8.09093948040456	0.926176044369926	0.991173656243115	1:24745356-24844324:+	CLIC4	46;GO:0001525,biological_process angiogenesis;GO:0001886,biological_process endothelial cell morphogenesis;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005911,cellular_component cell-cell junction;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0007035,biological_process vacuolar acidification;GO:0009566,biological_process fertilization;GO:0009986,cellular_component cell surface;GO:0015629,cellular_component actin cytoskeleton;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016363,cellular_component nuclear matrix;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030216,biological_process keratinocyte differentiation;GO:0030336,biological_process negative regulation of cell migration;GO:0030496,cellular_component midbody;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034707,cellular_component chloride channel complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0035088,biological_process establishment or maintenance of apical/basal cell polarity;GO:0035264,biological_process multicellular organism growth;GO:0045177,cellular_component apical part of cell;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0051493,biological_process regulation of cytoskeleton organization;GO:0061299,biological_process retina vasculature morphogenesis in camera-type eye;GO:0070062,cellular_component extracellular exosome;GO:0071277,biological_process cellular response to calcium ion;GO:1902476,biological_process chloride transmembrane transport	NA	chloride intracellular channel 4 [Source:HGNC Symbol%3BAcc:HGNC:13518]
ENSG00000115267	8.11	8.62	9.09	8.39	8.64	9.16	-0.00998855422027511	4.7646079909699	0.926311853598654	0.991233537820697	2:162267078-162318703:-	IFIH1	36;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0009597,biological_process detection of virus;GO:0009615,biological_process response to virus;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016925,biological_process protein sumoylation;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0034344,biological_process regulation of type III interferon production;GO:0035549,biological_process positive regulation of interferon-beta secretion;GO:0039528,biological_process cytoplasmic pattern recognition receptor signaling pathway in response to virus;GO:0039530,biological_process MDA-5 signaling pathway;GO:0042802,molecular_function identical protein binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051607,biological_process defense response to virus;GO:0060760,biological_process positive regulation of response to cytokine stimulus;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:1902741,biological_process positive regulation of interferon-alpha secretion;GO:1904469,biological_process positive regulation of tumor necrosis factor secretion;GO:2000778,biological_process positive regulation of interleukin-6 secretion	IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]; K12647	interferon induced with helicase C domain 1 [Source:HGNC Symbol%3BAcc:HGNC:18873]
ENSG00000119185	132.94	129.17	128.07	131.08	128.72	131.93	0.00626165272453689	6.41688987599649	0.926444454889709	0.9912613345175	2:9403474-9423547:-	ITGB1BP1	63;GO:0001525,biological_process angiogenesis;GO:0001726,cellular_component ruffle;GO:0002043,biological_process blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0005092,molecular_function GDP-dissociation inhibitor activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006933,biological_process negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007219,biological_process Notch signaling pathway;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008565,molecular_function protein transporter activity;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010764,biological_process negative regulation of fibroblast migration;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016477,biological_process cell migration;GO:0019900,molecular_function kinase binding;GO:0019901,molecular_function protein kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030154,biological_process cell differentiation;GO:0031214,biological_process biomineral tissue development;GO:0032091,biological_process negative regulation of protein binding;GO:0032148,biological_process activation of protein kinase B activity;GO:0032403,molecular_function protein complex binding;GO:0033622,biological_process integrin activation;GO:0033628,biological_process regulation of cell adhesion mediated by integrin;GO:0035148,biological_process tube formation;GO:0035556,biological_process intracellular signal transduction;GO:0035924,biological_process cellular response to vascular endothelial growth factor stimulus;GO:0042995,cellular_component cell projection;GO:0043087,biological_process regulation of GTPase activity;GO:0043113,biological_process receptor clustering;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050880,biological_process regulation of blood vessel size;GO:0051451,biological_process myoblast migration;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051781,biological_process positive regulation of cell division;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070062,cellular_component extracellular exosome;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0071944,cellular_component cell periphery;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:0090315,biological_process negative regulation of protein targeting to membrane;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:2001044,biological_process regulation of integrin-mediated signaling pathway	NA	integrin subunit beta 1 binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:23927]
ENSG00000198815	22.92	24.41	25.64	25.46	25.08	23.40	-0.0075770237075798	5.56465295952786	0.926523777985671	0.9912613345175	1:42176538-42335877:-	FOXJ3	12;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030154,biological_process cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	forkhead box J3 [Source:HGNC Symbol%3BAcc:HGNC:29178]
ENSG00000197121	3.16	2.91	3.46	3.25	2.85	3.63	-0.0140984576564186	3.19329788925753	0.926681786120171	0.9912613345175	2:196833003-196927796:-	PGAP1	19;GO:0004518,molecular_function nuclease activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0006810,biological_process transport;GO:0007605,biological_process sensory perception of sound;GO:0009880,biological_process embryonic pattern specification;GO:0009948,biological_process anterior/posterior axis specification;GO:0015031,biological_process protein transport;GO:0015798,biological_process myo-inositol transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016255,biological_process attachment of GPI anchor to protein;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0021871,biological_process forebrain regionalization;GO:0042578,molecular_function phosphoric ester hydrolase activity;GO:0060322,biological_process head development;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	PGAP1; GPI inositol-deacylase [EC:3.-.-.-]; K05294	post-GPI attachment to proteins 1 [Source:HGNC Symbol%3BAcc:HGNC:25712]
ENSG00000160062	5.98	5.06	7.18	5.66	6.42	6.59	-0.0127350363980223	3.05910658456295	0.926740775998858	0.9912613345175	1:32539426-32605939:+	ZBTB8A	10;GO:0003674,molecular_function molecular_function;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 8A [Source:HGNC Symbol%3BAcc:HGNC:24172]
ENSG00000229117	11842.54	11772.40	11775.20	12284.99	11383.45	12146.28	-0.00542307693227734	9.79895988580439	0.926750048374335	0.9912613345175	12:56116585-56117943:+	RPL41	14;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0048027,molecular_function mRNA 5'-UTR binding	NA	ribosomal protein L41 [Source:HGNC Symbol%3BAcc:HGNC:10354]
ENSG00000147592	121.72	157.06	126.25	127.13	157.65	120.45	0.00952555971208288	6.86699607417729	0.926816969983896	0.9912613345175	8:70635317-70669174:-	LACTB2	12;GO:0003723,molecular_function RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004521,molecular_function endoribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	lactamase beta 2 [Source:HGNC Symbol%3BAcc:HGNC:18512]
ENSG00000182173	11.86	10.82	10.42	11.85	10.05	11.73	-0.0101943171895962	4.38674894264376	0.926902127301621	0.991261570736603	17:75516059-75524739:+	TSEN54	12;GO:0000213,molecular_function tRNA-intron endonuclease activity;GO:0000214,cellular_component tRNA-intron endonuclease complex;GO:0000379,biological_process tRNA-type intron splice site recognition and cleavage;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0008033,biological_process tRNA processing;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	tRNA splicing endonuclease subunit 54 [Source:HGNC Symbol%3BAcc:HGNC:27561]
ENSG00000127526	8.72	8.10	8.28	8.89	8.35	8.35	-0.0125030847528751	3.43816544704068	0.926976904302787	0.991261570736603	19:16549830-16572382:-	SLC35E1	4;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member E1 [Source:HGNC Symbol%3BAcc:HGNC:20803]
ENSG00000072135	15.70	16.68	16.67	16.49	16.18	17.04	-0.0106118083820625	4.58037762853986	0.927230567639288	0.991337751869293	2:130356006-130375409:+	PTPN18	14;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0004726,molecular_function non-membrane spanning protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0038128,biological_process ERBB2 signaling pathway;GO:1901185,biological_process negative regulation of ERBB signaling pathway	NA	protein tyrosine phosphatase%2C non-receptor type 18 [Source:HGNC Symbol%3BAcc:HGNC:9649]
ENSG00000008282	116.27	119.24	122.44	115.33	120.05	123.95	0.00595381761526067	6.70022819756019	0.927285755925596	0.991337751869293	7:106090502-106112576:-	SYPL1	13;GO:0005215,molecular_function transporter activity;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0007268,biological_process chemical synaptic transmission;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030141,cellular_component secretory granule;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042470,cellular_component melanosome;GO:0070062,cellular_component extracellular exosome	NA	synaptophysin like 1 [Source:HGNC Symbol%3BAcc:HGNC:11507]
ENSG00000117222	10.02	11.19	10.21	10.86	10.76	10.24	-0.013622468013086	4.10007280006828	0.92728773358208	0.991337751869293	1:205086141-205122015:-	RBBP5	21;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016569,biological_process covalent chromatin modification;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0035064,molecular_function methylated histone binding;GO:0035097,cellular_component histone methyltransferase complex;GO:0042800,molecular_function histone methyltransferase activity (H3-K4 specific);GO:0043627,biological_process response to estrogen;GO:0043687,biological_process post-translational protein modification;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044666,cellular_component MLL3/4 complex;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0048188,cellular_component Set1C/COMPASS complex;GO:0051568,biological_process histone H3-K4 methylation;GO:0071339,cellular_component MLL1 complex;GO:1904837,biological_process beta-catenin-TCF complex assembly	RBBP5, SWD1, CPS50; COMPASS component SWD1; K14961	RB binding protein 5%2C histone lysine methyltransferase complex subunit [Source:HGNC Symbol%3BAcc:HGNC:9888]
ENSG00000107890	4.58	4.93	5.10	4.69	4.78	5.16	0.00750013072711886	4.71364495433255	0.927506651412174	0.99144834185273	10:26991913-27100498:-	ANKRD26	1;GO:0005813,cellular_component centrosome	NA	ankyrin repeat domain 26 [Source:HGNC Symbol%3BAcc:HGNC:29186]
ENSG00000099330	21.83	20.24	20.38	22.55	18.83	22.04	-0.00921897334753947	4.60639163789674	0.927629066039359	0.99144834185273	19:17226203-17229219:+	OCEL1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	occludin/ELL domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26221]
ENSG00000204394	25.27	27.24	26.32	26.06	25.32	28.43	-0.00753830199376446	6.6504161749227	0.927738921757805	0.99144834185273	6:31777517-31795953:-	VARS	14;GO:0000166,molecular_function nucleotide binding;GO:0002161,molecular_function aminoacyl-tRNA editing activity;GO:0004812,molecular_function aminoacyl-tRNA ligase activity;GO:0004832,molecular_function valine-tRNA ligase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006438,biological_process valyl-tRNA aminoacylation;GO:0006450,biological_process regulation of translational fidelity;GO:0016874,molecular_function ligase activity	VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]; K01873	valyl-tRNA synthetase [Source:HGNC Symbol%3BAcc:HGNC:12651]
ENSG00000136247	32.64	30.74	31.88	32.58	32.19	30.87	0.009388246324685	5.04537804217887	0.927743950017423	0.99144834185273	7:6577433-6589374:+	ZDHHC4	6;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity	NA	zinc finger DHHC-type containing 4 [Source:HGNC Symbol%3BAcc:HGNC:18471]
ENSG00000165244	6.66	7.55	5.33	7.84	5.27	6.23	0.0162888784482869	2.79179608474249	0.927845915600876	0.99144834185273	9:96385940-96418329:-	ZNF367	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 367 [Source:HGNC Symbol%3BAcc:HGNC:18320]
ENSG00000160229	0.30	0.63	0.49	0.53	0.75	0.20	-0.0703365458606961	0.206322349402477	0.927875306634276	0.99144834185273	19:20776303-20807322:+	ZNF66	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 66 [Source:HGNC Symbol%3BAcc:HGNC:13135]
ENSG00000197785	11.05	11.78	12.14	11.99	11.34	12.12	-0.0101309765610467	4.66048183130295	0.927950280806011	0.99144834185273	1:1512150-1534687:+	ATAD3A	9;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016049,biological_process cell growth;GO:0042645,cellular_component mitochondrial nucleoid;GO:0043066,biological_process negative regulation of apoptotic process	NA	ATPase family%2C AAA domain containing 3A [Source:HGNC Symbol%3BAcc:HGNC:25567]
ENSG00000145349	18.78	18.47	20.27	18.82	20.97	17.92	0.010143461579055	5.04276228461458	0.928542255325723	0.991995439827713	4:113451031-113761927:-	CAMK2D	75;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001558,biological_process regulation of cell growth;GO:0001666,biological_process response to hypoxia;GO:0002026,biological_process regulation of the force of heart contraction;GO:0003254,biological_process regulation of membrane depolarization;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004683,molecular_function calmodulin-dependent protein kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007399,biological_process nervous system development;GO:0008016,biological_process regulation of heart contraction;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0010649,biological_process regulation of cell communication by electrical coupling;GO:0010666,biological_process positive regulation of cardiac muscle cell apoptotic process;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881,biological_process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019871,molecular_function sodium channel inhibitor activity;GO:0030007,biological_process cellular potassium ion homeostasis;GO:0030154,biological_process cell differentiation;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031432,molecular_function titin binding;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0034704,cellular_component calcium channel complex;GO:0035022,biological_process positive regulation of Rac protein signal transduction;GO:0042383,cellular_component sarcolemma;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043234,cellular_component protein complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044325,molecular_function ion channel binding;GO:0046777,biological_process protein autophosphorylation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050998,molecular_function nitric-oxide synthase binding;GO:0051259,biological_process protein oligomerization;GO:0055119,biological_process relaxation of cardiac muscle;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0060341,biological_process regulation of cellular localization;GO:0061049,biological_process cell growth involved in cardiac muscle cell development;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071277,biological_process cellular response to calcium ion;GO:0086003,biological_process cardiac muscle cell contraction;GO:0086091,biological_process regulation of heart rate by cardiac conduction;GO:0098901,biological_process regulation of cardiac muscle cell action potential;GO:0098909,biological_process regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:1900034,biological_process regulation of cellular response to heat;GO:1901725,biological_process regulation of histone deacetylase activity;GO:1901844,biological_process regulation of cell communication by electrical coupling involved in cardiac conduction;GO:1901897,biological_process regulation of relaxation of cardiac muscle;GO:1902306,biological_process negative regulation of sodium ion transmembrane transport;GO:1902514,biological_process regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:1903076,biological_process regulation of protein localization to plasma membrane;GO:2000650,biological_process negative regulation of sodium ion transmembrane transporter activity	CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]; K04515	calcium/calmodulin dependent protein kinase II delta [Source:HGNC Symbol%3BAcc:HGNC:1462]
ENSG00000074966	1.06	0.78	0.51	0.80	0.95	0.70	-0.0409402671176495	0.517309867702244	0.928962149351448	0.992012723669869	4:48066392-48134256:-	TXK	40;GO:0000166,molecular_function nucleotide binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001012,molecular_function RNA polymerase II regulatory region DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001816,biological_process cytokine production;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0003677,molecular_function DNA binding;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007202,biological_process activation of phospholipase C activity;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0010543,biological_process regulation of platelet activation;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030154,biological_process cell differentiation;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0042127,biological_process regulation of cell proliferation;GO:0042246,biological_process tissue regeneration;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046777,biological_process protein autophosphorylation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0060335,biological_process positive regulation of interferon-gamma-mediated signaling pathway	TXK, RLK; tyrosine-protein kinase TXK [EC:2.7.10.2]; K08016	TXK tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:12434]
ENSG00000162526	26.00	24.01	28.93	24.49	26.13	28.51	0.0126558925390031	4.41920517386286	0.928986682959469	0.992012723669869	1:32351520-32364312:+	TSSK3	17;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030154,biological_process cell differentiation;GO:0035556,biological_process intracellular signal transduction;GO:0046872,molecular_function metal ion binding	NA	testis specific serine kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:15473]
ENSG00000121104	4.66	6.64	5.68	5.57	6.23	5.03	0.0123036431345326	3.02249574518501	0.929006565391926	0.992012723669869	17:49710331-49789180:-	FAM117A	NA	NA	family with sequence similarity 117 member A [Source:HGNC Symbol%3BAcc:HGNC:24179]
ENSG00000171466	8.84	7.70	7.60	7.73	8.60	8.25	-0.00943639612558449	3.40016675700153	0.92902798543813	0.992012723669869	19:9641807-9675086:-	ZNF562	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 562 [Source:HGNC Symbol%3BAcc:HGNC:25950]
ENSG00000161243	4.54	5.06	3.97	3.89	5.09	4.45	0.0152684650421744	2.29078889780794	0.929036280751589	0.992012723669869	19:38990713-39032785:-	FBXO27	6;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0043687,biological_process post-translational protein modification	NA	F-box protein 27 [Source:HGNC Symbol%3BAcc:HGNC:18753]
ENSG00000165912	11.13	10.19	9.58	8.68	11.83	10.31	0.0167785498789142	3.7318010796634	0.92903793705488	0.992012723669869	11:47177524-47186443:-	PACSIN3	17;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008289,molecular_function lipid binding;GO:0016020,cellular_component membrane;GO:0019855,molecular_function calcium channel inhibitor activity;GO:0030100,biological_process regulation of endocytosis;GO:0045806,biological_process negative regulation of endocytosis;GO:0051044,biological_process positive regulation of membrane protein ectodomain proteolysis;GO:0051926,biological_process negative regulation of calcium ion transport;GO:0065009,biological_process regulation of molecular function;GO:0070062,cellular_component extracellular exosome;GO:0097320,biological_process membrane tubulation	NA	protein kinase C and casein kinase substrate in neurons 3 [Source:HGNC Symbol%3BAcc:HGNC:8572]
ENSG00000119041	19.69	20.37	19.64	20.19	20.56	19.68	-0.00694858001098352	5.83756434427768	0.929134515442423	0.992030512660141	2:196763031-196799725:-	GTF3C3	15;GO:0000127,cellular_component transcription factor TFIIIC complex;GO:0000995,molecular_function transcription factor activity, core RNA polymerase III binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006359,biological_process regulation of transcription from RNA polymerase III promoter;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0042791,biological_process 5S class rRNA transcription from RNA polymerase III type 1 promoter;GO:0042797,biological_process tRNA transcription from RNA polymerase III promoter	NA	general transcription factor IIIC subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:4666]
ENSG00000142599	16.79	17.17	16.29	16.67	18.06	16.14	-0.00667321864598587	6.41990131288556	0.92941855798401	0.992203279711163	1:8352396-8817643:-	RERE	25;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0001106,molecular_function RNA polymerase II transcription corepressor activity;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0007275,biological_process multicellular organism development;GO:0008267,molecular_function poly-glutamine tract binding;GO:0008270,molecular_function zinc ion binding;GO:0021549,biological_process cerebellum development;GO:0021691,biological_process cerebellar Purkinje cell layer maturation;GO:0021930,biological_process cerebellar granule cell precursor proliferation;GO:0021942,biological_process radial glia guided migration of Purkinje cell;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048755,biological_process branching morphogenesis of a nerve;GO:0048813,biological_process dendrite morphogenesis	RERE; arginine-glutamic acid dipeptide repeats protein; K05628	arginine-glutamic acid dipeptide repeats [Source:HGNC Symbol%3BAcc:HGNC:9965]
ENSG00000099326	7.62	6.67	7.90	7.09	7.18	8.00	0.0129052957967372	4.04998403967838	0.929509437571036	0.992203279711163	19:58561930-58573575:-	MZF1	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0042803,molecular_function protein homodimerization activity;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	myeloid zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:13108]
ENSG00000117906	59.73	59.80	52.08	56.40	60.02	57.33	-0.00779540203998873	5.9211173656701	0.929623198008033	0.992203279711163	15:76931618-76954392:+	RCN2	6;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0046872,molecular_function metal ion binding	NA	reticulocalbin 2 [Source:HGNC Symbol%3BAcc:HGNC:9935]
ENSG00000147813	2.70	1.24	1.86	1.98	2.05	2.02	-0.0192907420484672	1.89414665070635	0.929688349231485	0.992203279711163	8:143574784-143578649:-	NAPRT	17;GO:0004514,molecular_function nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0004516,molecular_function nicotinate phosphoribosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006979,biological_process response to oxidative stress;GO:0009435,biological_process NAD biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016874,molecular_function ligase activity;GO:0019358,biological_process nicotinate nucleotide salvage;GO:0019363,biological_process pyridine nucleotide biosynthetic process;GO:0034356,biological_process NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0035578,cellular_component azurophil granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0070062,cellular_component extracellular exosome	pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]; K00763	nicotinate phosphoribosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:30450]
ENSG00000139990	27.79	31.33	32.26	30.95	29.64	31.08	0.00594479012233217	6.48244987613849	0.929698994811872	0.992203279711163	14:69050880-69153150:-	DCAF5	5;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 5 [Source:HGNC Symbol%3BAcc:HGNC:20224]
ENSG00000138386	19.19	16.09	17.13	18.60	16.92	17.76	-0.0062453254076097	4.6980581730398	0.929827358311608	0.992203279711163	2:190646745-190692766:+	NAB1	9;GO:0001958,biological_process endochondral ossification;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0014037,biological_process Schwann cell differentiation;GO:0042552,biological_process myelination;GO:0045682,biological_process regulation of epidermis development;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	NGFI-A binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7626]
ENSG00000103018	100.46	107.72	92.64	94.88	106.41	103.20	-0.00949497324468935	5.552720633184	0.930113380218883	0.992203279711163	16:69424524-69466266:+	CYB5B	13;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006805,biological_process xenobiotic metabolic process;GO:0008047,molecular_function enzyme activator activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0020037,molecular_function heme binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	cytochrome b5 type B [Source:HGNC Symbol%3BAcc:HGNC:24374]
ENSG00000160058	34.70	31.77	34.18	34.34	35.86	31.89	-0.00511570101972249	5.72701914353236	0.930119403658462	0.992203279711163	1:32365102-32394731:-	BSDC1	NA	NA	BSD domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25501]
ENSG00000163590	0.83	1.21	1.53	1.22	1.44	1.08	-0.0575561407755212	0.580221745104087	0.930183257857519	0.992203279711163	3:160755601-161078907:+	PPM1L	14;GO:0000165,biological_process MAPK cascade;GO:0003824,molecular_function catalytic activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006470,biological_process protein dephosphorylation;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0043169,molecular_function cation binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	protein phosphatase%2C Mg2+/Mn2+ dependent 1L [Source:HGNC Symbol%3BAcc:HGNC:16381]
ENSG00000100304	13.60	10.78	12.95	11.47	12.76	13.25	0.0139490453796472	4.60508885014865	0.930238680528296	0.992203279711163	22:43166621-43187133:-	TTLL12	5;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005524,molecular_function ATP binding;GO:0006464,biological_process cellular protein modification process;GO:0016874,molecular_function ligase activity	NA	tubulin tyrosine ligase like 12 [Source:HGNC Symbol%3BAcc:HGNC:28974]
ENSG00000155506	48.89	45.91	46.56	46.57	49.09	47.44	-0.00522639422005188	7.42308710603256	0.930308060862957	0.992203279711163	5:154712901-154817607:+	LARP1	27;GO:0000339,molecular_function RNA cap binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0008190,molecular_function eukaryotic initiation factor 4E binding;GO:0008283,biological_process cell proliferation;GO:0008494,molecular_function translation activator activity;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0017148,biological_process negative regulation of translation;GO:0031369,molecular_function translation initiation factor binding;GO:0031929,biological_process TOR signaling;GO:0031931,cellular_component TORC1 complex;GO:0038202,biological_process TORC1 signaling;GO:0045070,biological_process positive regulation of viral genome replication;GO:0045296,molecular_function cadherin binding;GO:0045727,biological_process positive regulation of translation;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0048255,biological_process mRNA stabilization;GO:0072752,biological_process cellular response to rapamycin;GO:1990928,biological_process response to amino acid starvation	NA	La ribonucleoprotein domain family member 1 [Source:HGNC Symbol%3BAcc:HGNC:29531]
ENSG00000140939	32.58	29.11	36.12	32.78	32.46	32.99	0.0113807695138433	5.07024352595231	0.930358851626663	0.992203279711163	16:67170153-67175735:+	NOL3	44;GO:0001666,biological_process response to hypoxia;GO:0001974,biological_process blood vessel remodeling;GO:0002931,biological_process response to ischemia;GO:0003723,molecular_function RNA binding;GO:0005102,molecular_function receptor binding;GO:0005123,molecular_function death receptor binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006376,biological_process mRNA splice site selection;GO:0006397,biological_process mRNA processing;GO:0006915,biological_process apoptotic process;GO:0008380,biological_process RNA splicing;GO:0010468,biological_process regulation of gene expression;GO:0010659,biological_process cardiac muscle cell apoptotic process;GO:0010664,biological_process negative regulation of striated muscle cell apoptotic process;GO:0010667,biological_process negative regulation of cardiac muscle cell apoptotic process;GO:0010804,biological_process negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0014736,biological_process negative regulation of muscle atrophy;GO:0014808,biological_process release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014876,biological_process response to injury involved in regulation of muscle adaptation;GO:0016020,cellular_component membrane;GO:0016528,cellular_component sarcoplasm;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0035877,molecular_function death effector domain binding;GO:0042345,biological_process regulation of NF-kappaB import into nucleus;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0051259,biological_process protein oligomerization;GO:0060547,biological_process negative regulation of necrotic cell death;GO:0089720,molecular_function caspase binding;GO:0090201,biological_process negative regulation of release of cytochrome c from mitochondria;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1902109,biological_process negative regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1990001,biological_process inhibition of cysteine-type endopeptidase activity involved in apoptotic process;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	nucleolar protein 3 [Source:HGNC Symbol%3BAcc:HGNC:7869]
ENSG00000186395	27.92	30.94	24.61	27.76	26.29	30.46	-0.0106996665219617	5.71495800693568	0.93054185718548	0.992203279711163	17:40818116-40822595:-	KRT10	15;GO:0001533,cellular_component cornified envelope;GO:0005198,molecular_function structural molecule activity;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005882,cellular_component intermediate filament;GO:0016020,cellular_component membrane;GO:0018149,biological_process peptide cross-linking;GO:0030216,biological_process keratinocyte differentiation;GO:0030280,molecular_function structural constituent of epidermis;GO:0031424,biological_process keratinization;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification;GO:0098773,biological_process skin epidermis development	KRT1; type I keratin, acidic; K07604	keratin 10 [Source:HGNC Symbol%3BAcc:HGNC:6413]
ENSG00000095794	11.79	11.27	12.78	11.59	12.66	12.21	-0.00853031758642694	4.18296594648713	0.930588628138154	0.992203279711163	10:35126790-35212958:+	CREM	23;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0006006,biological_process glucose metabolic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006631,biological_process fatty acid metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008140,molecular_function cAMP response element binding protein binding;GO:0030154,biological_process cell differentiation;GO:0042752,biological_process regulation of circadian rhythm;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048384,biological_process retinoic acid receptor signaling pathway;GO:0048511,biological_process rhythmic process	CREM; cAMP response element modulator; K09052	cAMP responsive element modulator [Source:HGNC Symbol%3BAcc:HGNC:2352]
ENSG00000168679	1.22	0.89	0.69	0.90	0.76	1.03	0.0766478856709404	0.615659911950253	0.930849611394736	0.992203279711163	1:110362847-110391082:-	SLC16A4	9;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0008028,molecular_function monocarboxylic acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015718,biological_process monocarboxylic acid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 16 member 4 [Source:HGNC Symbol%3BAcc:HGNC:10925]
ENSG00000133597	14.03	13.71	13.62	12.66	14.22	15.06	-0.00896487707085884	4.84982578323424	0.930888220753675	0.992203279711163	7:140673152-140696261:+	ADCK2	10;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity	NA	aarF domain containing kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:19039]
ENSG00000154767	17.51	20.50	18.14	19.49	18.72	18.03	0.00510883501733886	5.7257708991471	0.930917763802954	0.992203279711163	3:14145146-14178783:-	XPC	30;GO:0000111,cellular_component nucleotide-excision repair factor 2 complex;GO:0000404,molecular_function heteroduplex DNA loop binding;GO:0000405,molecular_function bubble DNA binding;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010224,biological_process response to UV-B;GO:0010996,biological_process response to auditory stimulus;GO:0031573,biological_process intra-S DNA damage checkpoint;GO:0042493,biological_process response to drug;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0070914,biological_process UV-damage excision repair;GO:0071942,cellular_component XPC complex;GO:1901990,biological_process regulation of mitotic cell cycle phase transition	XPC; xeroderma pigmentosum group C-complementing protein; K10838	XPC complex subunit%2C DNA damage recognition and repair factor [Source:HGNC Symbol%3BAcc:HGNC:12816]
ENSG00000116922	18.67	17.58	17.89	18.69	16.69	19.74	-0.013569533778393	3.49384996512525	0.930925565553651	0.992203279711163	1:37681569-37692249:-	C1orf109	3;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm	NA	chromosome 1 open reading frame 109 [Source:HGNC Symbol%3BAcc:HGNC:26039]
ENSG00000122386	8.37	5.92	7.75	6.31	7.85	7.95	0.0188548142075162	3.64006869399552	0.930949140885795	0.992203279711163	16:3112559-3120517:+	ZNF205	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0010729,biological_process positive regulation of hydrogen peroxide biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 205 [Source:HGNC Symbol%3BAcc:HGNC:12996]
ENSG00000204713	22.27	16.61	19.78	19.47	19.25	20.95	-0.0058716529109277	5.00253486283893	0.930968051347304	0.992203279711163	6:28903001-28923989:-	TRIM27	45;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001650,cellular_component fibrillar center;GO:0002820,biological_process negative regulation of adaptive immune response;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006810,biological_process transport;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030904,cellular_component retromer complex;GO:0031965,cellular_component nuclear membrane;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032897,biological_process negative regulation of viral transcription;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042802,molecular_function identical protein binding;GO:0045087,biological_process innate immune response;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070206,biological_process protein trimerization;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0072643,biological_process interferon-gamma secretion;GO:0090281,biological_process negative regulation of calcium ion import;GO:1900041,biological_process negative regulation of interleukin-2 secretion	NA	tripartite motif containing 27 [Source:HGNC Symbol%3BAcc:HGNC:9975]
ENSG00000177721	4.64	5.94	7.50	8.02	5.89	4.74	-0.0315003957562729	1.88290067727891	0.931110965443306	0.992203279711163	5:43039080-43043170:-	ANXA2R	1;GO:0004872,molecular_function receptor activity	NA	annexin A2 receptor [Source:HGNC Symbol%3BAcc:HGNC:33463]
ENSG00000111641	14.25	14.52	15.24	15.08	14.53	14.98	-0.00701061754568911	5.29791282792192	0.931247253826993	0.992203279711163	12:6556862-6568691:-	NOP2	18;GO:0000027,biological_process ribosomal large subunit assembly;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006364,biological_process rRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0009383,molecular_function rRNA (cytosine-C5-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0042254,biological_process ribosome biogenesis;GO:0070475,biological_process rRNA base methylation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	NOP2 nucleolar protein [Source:HGNC Symbol%3BAcc:HGNC:7867]
ENSG00000143845	3.35	3.16	3.68	3.11	3.40	3.92	-0.0192320159717598	2.45109338442885	0.931307605347505	0.992203279711163	1:204131061-204152003:-	ETNK2	16;GO:0000166,molecular_function nucleotide binding;GO:0001701,biological_process in utero embryonic development;GO:0001890,biological_process placenta development;GO:0004305,molecular_function ethanolamine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005575,cellular_component cellular_component;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0008150,biological_process biological_process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009791,biological_process post-embryonic development;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035264,biological_process multicellular organism growth	ETNK, EKI; ethanolamine kinase [EC:2.7.1.82]; K00894	ethanolamine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:25575]
ENSG00000107249	11.54	10.24	10.74	10.71	10.74	11.57	-0.00633191689440973	4.93967827690236	0.931397572563677	0.992203279711163	9:3824126-4348392:-	GLIS3	10;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	GLIS family zinc finger 3 [Source:HGNC Symbol%3BAcc:HGNC:28510]
ENSG00000100804	108.08	120.48	103.40	114.41	118.64	103.04	-0.0079302576345234	6.66300161439893	0.931430659605534	0.992203279711163	14:23016542-23035230:-	PSMB5	42;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0004175,molecular_function endopeptidase activity;GO:0004298,molecular_function threonine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005839,cellular_component proteasome core complex;GO:0006508,biological_process proteolysis;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0008233,molecular_function peptidase activity;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0019774,cellular_component proteasome core complex, beta-subunit complex;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070062,cellular_component extracellular exosome;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	PSMB5; 20S proteasome subunit beta 5 [EC:3.4.25.1]; K02737	proteasome subunit beta 5 [Source:HGNC Symbol%3BAcc:HGNC:9542]
ENSG00000267796	14.70	14.46	13.83	14.27	13.22	16.25	-0.0163918500056855	3.44138051605519	0.931437517161238	0.992203279711163	19:35748360-35754519:+	LIN37	5;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0007049,biological_process cell cycle;GO:0017053,cellular_component transcriptional repressor complex;GO:0051726,biological_process regulation of cell cycle	NA	lin-37 DREAM MuvB core complex component [Source:HGNC Symbol%3BAcc:HGNC:33234]
ENSG00000031003	9.12	9.66	9.56	9.30	9.98	9.43	-0.00919001773683699	4.74816449525615	0.931463735579962	0.992203279711163	5:137937959-138051961:-	FAM13B	5;GO:0005096,molecular_function GTPase activator activity;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	family with sequence similarity 13 member B [Source:HGNC Symbol%3BAcc:HGNC:1335]
ENSG00000175581	27.80	33.78	30.14	31.73	32.15	27.68	0.00810236595396534	4.41643355273746	0.931695776265954	0.992203279711163	11:73787315-73865133:+	MRPL48	9;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L48 [Source:HGNC Symbol%3BAcc:HGNC:16653]
ENSG00000037474	60.83	56.61	59.81	59.35	59.36	59.38	0.00615374101983359	7.09335061938528	0.931729328637587	0.992203279711163	5:6599238-6633291:-	NSUN2	21;GO:0000049,molecular_function tRNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0006400,biological_process tRNA modification;GO:0007049,biological_process cell cycle;GO:0007286,biological_process spermatid development;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016428,molecular_function tRNA (cytosine-5-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation;GO:0033313,biological_process meiotic cell cycle checkpoint;GO:0033391,cellular_component chromatoid body;GO:0048820,biological_process hair follicle maturation;GO:0051301,biological_process cell division	NA	NOP2/Sun RNA methyltransferase family member 2 [Source:HGNC Symbol%3BAcc:HGNC:25994]
ENSG00000087237	0.86	1.10	1.14	1.01	1.03	0.95	0.0568267935416469	0.720006241673017	0.931756448325368	0.992203279711163	16:56961849-56983845:+	CETP	32;GO:0005319,molecular_function lipid transporter activity;GO:0005548,molecular_function phospholipid transporter activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006629,biological_process lipid metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0008289,molecular_function lipid binding;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010874,biological_process regulation of cholesterol efflux;GO:0015485,molecular_function cholesterol binding;GO:0015914,biological_process phospholipid transport;GO:0017127,molecular_function cholesterol transporter activity;GO:0017129,molecular_function triglyceride binding;GO:0030301,biological_process cholesterol transport;GO:0031210,molecular_function phosphatidylcholine binding;GO:0031982,cellular_component vesicle;GO:0034197,biological_process triglyceride transport;GO:0034364,cellular_component high-density lipoprotein particle;GO:0034372,biological_process very-low-density lipoprotein particle remodeling;GO:0034374,biological_process low-density lipoprotein particle remodeling;GO:0034375,biological_process high-density lipoprotein particle remodeling;GO:0042632,biological_process cholesterol homeostasis;GO:0043691,biological_process reverse cholesterol transport;GO:0046470,biological_process phosphatidylcholine metabolic process;GO:0055088,biological_process lipid homeostasis;GO:0055091,biological_process phospholipid homeostasis;GO:0070062,cellular_component extracellular exosome;GO:0070328,biological_process triglyceride homeostasis	CETP; cholesteryl ester transfer protein; K16835	cholesteryl ester transfer protein [Source:HGNC Symbol%3BAcc:HGNC:1869]
ENSG00000198951	20.51	25.42	25.07	24.41	26.45	21.16	-0.0116592856317316	4.88213338332273	0.9317742392325	0.992203279711163	22:42058353-42070842:-	NAGA	17;GO:0003824,molecular_function catalytic activity;GO:0004553,molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004557,molecular_function alpha-galactosidase activity;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005975,biological_process carbohydrate metabolic process;GO:0008152,biological_process metabolic process;GO:0008456,molecular_function alpha-N-acetylgalactosaminidase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0016052,biological_process carbohydrate catabolic process;GO:0016139,biological_process glycoside catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0019377,biological_process glycolipid catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0046477,biological_process glycosylceramide catabolic process;GO:0070062,cellular_component extracellular exosome	NAGA; alpha-N-acetylgalactosaminidase [EC:3.2.1.49]; K01204	alpha-N-acetylgalactosaminidase [Source:HGNC Symbol%3BAcc:HGNC:7631]
ENSG00000108984	4.13	5.12	3.15	3.43	4.73	4.04	0.0184069272094923	2.11274361044893	0.93196861791188	0.992247197411463	17:69414697-69543331:+	MAP2K6	42;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002931,biological_process response to ischemia;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0022602,biological_process ovulation cycle process;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0032147,biological_process activation of protein kinase activity;GO:0032308,biological_process positive regulation of prostaglandin secretion;GO:0035897,biological_process proteolysis in other organism;GO:0042493,biological_process response to drug;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0051770,biological_process positive regulation of nitric-oxide synthase biosynthetic process;GO:0060048,biological_process cardiac muscle contraction;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0072709,biological_process cellular response to sorbitol	MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]; K04433	mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:6846]
ENSG00000153487	5.78	4.55	4.19	5.91	5.23	3.75	-0.0175956025092884	2.81867285804606	0.932053610915445	0.992247197411463	13:110712735-110723339:+	ING1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007049,biological_process cell cycle;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010941,biological_process regulation of cell death;GO:0016569,biological_process covalent chromatin modification;GO:0030308,biological_process negative regulation of cell growth;GO:0035064,molecular_function methylated histone binding;GO:0046872,molecular_function metal ion binding	NA	inhibitor of growth family member 1 [Source:HGNC Symbol%3BAcc:HGNC:6062]
ENSG00000003393	15.36	15.37	16.09	16.53	14.77	16.11	-0.00612749402461054	6.33781681960175	0.932055290567764	0.992247197411463	2:201700553-201781189:-	ALS2	48;GO:0001662,biological_process behavioral fear response;GO:0001701,biological_process in utero embryonic development;GO:0001726,cellular_component ruffle;GO:0001881,biological_process receptor recycling;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006979,biological_process response to oxidative stress;GO:0007032,biological_process endosome organization;GO:0007409,biological_process axonogenesis;GO:0007528,biological_process neuromuscular junction development;GO:0007626,biological_process locomotory behavior;GO:0008104,biological_process protein localization;GO:0008219,biological_process cell death;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0016197,biological_process endosomal transport;GO:0016601,biological_process Rac protein signal transduction;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030027,cellular_component lamellipodium;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0031982,cellular_component vesicle;GO:0035022,biological_process positive regulation of Rac protein signal transduction;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043087,biological_process regulation of GTPase activity;GO:0043197,cellular_component dendritic spine;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0048812,biological_process neuron projection morphogenesis;GO:0051036,biological_process regulation of endosome size;GO:0061024,biological_process membrane organization;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity	ALS2; amyotrophic lateral sclerosis 2 protein; K04575	ALS2%2C alsin Rho guanine nucleotide exchange factor [Source:HGNC Symbol%3BAcc:HGNC:443]
ENSG00000136463	27.98	28.53	28.66	28.23	29.37	27.78	0.00811458491465285	4.67161155552539	0.93214584746787	0.992258503097391	17:63600871-63608365:+	TACO1	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0006417,biological_process regulation of translation	NA	translational activator of cytochrome c oxidase I [Source:HGNC Symbol%3BAcc:HGNC:24316]
ENSG00000162783	9.36	9.06	11.48	10.84	9.20	9.82	0.019643248091836	3.31468475135628	0.932549606816835	0.992531955875943	1:181088711-181092899:+	IER5	11;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0034605,biological_process cellular response to heat;GO:0042127,biological_process regulation of cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1900036,biological_process positive regulation of cellular response to heat	NA	immediate early response 5 [Source:HGNC Symbol%3BAcc:HGNC:5393]
ENSG00000090339	58.81	55.39	61.24	61.17	56.36	58.69	0.00694801466024612	6.55151984916753	0.93256265216959	0.992531955875943	19:10270834-10286615:+	ICAM1	80;GO:0001541,biological_process ovarian follicle development;GO:0001618,molecular_function virus receptor activity;GO:0001666,biological_process response to hypoxia;GO:0001772,cellular_component immunological synapse;GO:0001910,biological_process regulation of leukocyte mediated cytotoxicity;GO:0001975,biological_process response to amphetamine;GO:0002291,biological_process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0002438,biological_process acute inflammatory response to antigenic stimulus;GO:0002457,biological_process T cell antigen processing and presentation;GO:0002693,biological_process positive regulation of cellular extravasation;GO:0004872,molecular_function receptor activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005178,molecular_function integrin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0007155,biological_process cell adhesion;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159,biological_process leukocyte cell-cell adhesion;GO:0007569,biological_process cell aging;GO:0007605,biological_process sensory perception of sound;GO:0008360,biological_process regulation of cell shape;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010212,biological_process response to ionizing radiation;GO:0010477,biological_process response to sulfur dioxide;GO:0014070,biological_process response to organic cyclic compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0022614,biological_process membrane to membrane docking;GO:0030155,biological_process regulation of cell adhesion;GO:0030198,biological_process extracellular matrix organization;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031669,biological_process cellular response to nutrient levels;GO:0032403,molecular_function protein complex binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0032868,biological_process response to insulin;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0034698,biological_process response to gonadotropin;GO:0042493,biological_process response to drug;GO:0043200,biological_process response to amino acid;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044406,biological_process adhesion of symbiont to host;GO:0045121,cellular_component membrane raft;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045471,biological_process response to ethanol;GO:0045907,biological_process positive regulation of vasoconstriction;GO:0046688,biological_process response to copper ion;GO:0046718,biological_process viral entry into host cell;GO:0046813,biological_process receptor-mediated virion attachment to host cell;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050776,biological_process regulation of immune response;GO:0050900,biological_process leukocyte migration;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051926,biological_process negative regulation of calcium ion transport;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071310,biological_process cellular response to organic substance;GO:0071312,biological_process cellular response to alkaloid;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071346,biological_process cellular response to interferon-gamma;GO:0071347,biological_process cellular response to interleukin-1;GO:0071354,biological_process cellular response to interleukin-6;GO:0071356,biological_process cellular response to tumor necrosis factor;GO:0071456,biological_process cellular response to hypoxia;GO:0071549,biological_process cellular response to dexamethasone stimulus;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:0097368,biological_process establishment of Sertoli cell barrier;GO:1900027,biological_process regulation of ruffle assembly;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1904996,biological_process positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	ICAM1, CD54; intercellular adhesion molecule 1; K06490	intercellular adhesion molecule 1 [Source:HGNC Symbol%3BAcc:HGNC:5344]
ENSG00000204152	8.52	6.53	8.13	7.29	7.28	8.59	0.0261374688302152	2.46021402258092	0.93276393593675	0.992568537734172	10:49942032-49974850:+	TIMM23B	15;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005744,cellular_component mitochondrial inner membrane presequence translocase complex;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008150,biological_process biological_process;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0015450,molecular_function P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0031305,cellular_component integral component of mitochondrial inner membrane	NA	translocase of inner mitochondrial membrane 23 homolog B [Source:HGNC Symbol%3BAcc:HGNC:23581]
ENSG00000112237	58.50	58.44	59.34	59.10	59.80	58.12	0.00599491983685816	6.06031140749218	0.932788644428934	0.992568537734172	6:99542379-99568973:-	CCNC	15;GO:0000307,cellular_component cyclin-dependent protein kinase holoenzyme complex;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0016592,cellular_component mediator complex;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045859,biological_process regulation of protein kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1901409,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain	NA	cyclin C [Source:HGNC Symbol%3BAcc:HGNC:1581]
ENSG00000156030	29.68	26.75	31.01	29.20	29.24	30.17	-0.00505080092208812	6.64798086274601	0.932876892916564	0.992568537734172	14:73715121-73790285:-	ELMSAN1	12;GO:0000118,cellular_component histone deacetylase complex;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0044212,molecular_function transcription regulatory region DNA binding	NA	ELM2 and Myb/SANT domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:19853]
ENSG00000164077	2.37	2.72	1.83	2.13	2.70	2.00	0.0199562522762793	2.21081975069036	0.932930247191225	0.992568537734172	3:49908861-49930173:-	MON1A	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0009306,biological_process protein secretion;GO:0012505,cellular_component endomembrane system;GO:0016192,biological_process vesicle-mediated transport;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	MON1 homolog A%2C secretory trafficking associated [Source:HGNC Symbol%3BAcc:HGNC:28207]
ENSG00000115041	5.98	10.35	7.56	7.27	8.90	7.46	0.00998249352638587	2.82575551922118	0.933142253135194	0.992568537734172	2:95297303-95386083:+	KCNIP3	41;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0006886,biological_process intracellular protein transport;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0032993,cellular_component protein-DNA complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043679,cellular_component axon terminus;GO:0044325,molecular_function ion channel binding;GO:0046872,molecular_function metal ion binding;GO:0061337,biological_process cardiac conduction;GO:0065009,biological_process regulation of molecular function;GO:0071805,biological_process potassium ion transmembrane transport;GO:0072659,biological_process protein localization to plasma membrane;GO:1901379,biological_process regulation of potassium ion transmembrane transport;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	potassium voltage-gated channel interacting protein 3 [Source:HGNC Symbol%3BAcc:HGNC:15523]
ENSG00000171055	43.25	39.54	36.22	34.18	40.14	44.95	0.0084765298748324	5.65546769095459	0.933333238575052	0.992568537734172	2:36531804-36646087:-	FEZ2	7;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0007411,biological_process axon guidance;GO:0030424,cellular_component axon;GO:1902902,biological_process negative regulation of autophagosome assembly	NA	fasciculation and elongation protein zeta 2 [Source:HGNC Symbol%3BAcc:HGNC:3660]
ENSG00000182903	9.57	8.83	9.56	10.54	9.20	8.30	0.011451995051802	4.83644820278586	0.93335025952165	0.992568537734172	4:425814-499156:-	ZNF721	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 721 [Source:HGNC Symbol%3BAcc:HGNC:29425]
ENSG00000116525	2.69	2.93	3.15	1.99	3.25	3.40	0.03103131842079	2.14411287685881	0.933394300110971	0.992568537734172	1:33145401-33182059:-	TRIM62	17;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0010719,biological_process negative regulation of epithelial to mesenchymal transition;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0032897,biological_process negative regulation of viral transcription;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0046596,biological_process regulation of viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0060333,biological_process interferon-gamma-mediated signaling pathway;GO:1902186,biological_process regulation of viral release from host cell	NA	tripartite motif containing 62 [Source:HGNC Symbol%3BAcc:HGNC:25574]
ENSG00000129170	3.03	1.81	2.15	2.57	1.30	2.90	0.0725147567283869	0.591009191661566	0.933394825413812	0.992568537734172	11:19182029-19210573:-	CSRP3	27;GO:0002026,biological_process regulation of the force of heart contraction;GO:0003300,biological_process cardiac muscle hypertrophy;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0007519,biological_process skeletal muscle tissue development;GO:0008307,molecular_function structural constituent of muscle;GO:0030017,cellular_component sarcomere;GO:0030018,cellular_component Z disc;GO:0030154,biological_process cell differentiation;GO:0031433,molecular_function telethonin binding;GO:0033365,biological_process protein localization to organelle;GO:0035995,biological_process detection of muscle stretch;GO:0042802,molecular_function identical protein binding;GO:0042805,molecular_function actinin binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048738,biological_process cardiac muscle tissue development;GO:0055003,biological_process cardiac myofibril assembly;GO:0060048,biological_process cardiac muscle contraction	NA	cysteine and glycine rich protein 3 [Source:HGNC Symbol%3BAcc:HGNC:2472]
ENSG00000134508	11.63	12.17	11.90	11.96	11.66	12.14	0.00676506803977969	4.59048688696604	0.933396643919358	0.992568537734172	18:23134563-23260467:+	CABLES1	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007399,biological_process nervous system development;GO:0051301,biological_process cell division;GO:0051726,biological_process regulation of cell cycle	NA	Cdk5 and Abl enzyme substrate 1 [Source:HGNC Symbol%3BAcc:HGNC:25097]
ENSG00000115020	8.09	8.64	8.33	7.94	8.63	8.57	0.00505135093678505	5.73255260396524	0.933734756181125	0.992751534971647	2:208266266-208358751:+	PIKFYVE	35;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0000285,molecular_function 1-phosphatidylinositol-3-phosphate 5-kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005911,cellular_component cell-cell junction;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0008270,molecular_function zinc ion binding;GO:0010008,cellular_component endosome membrane;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016307,molecular_function phosphatidylinositol phosphate kinase activity;GO:0016308,molecular_function 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0032288,biological_process myelin assembly;GO:0034504,biological_process protein localization to nucleus;GO:0035556,biological_process intracellular signal transduction;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043813,molecular_function phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0045121,cellular_component membrane raft;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:1904562,biological_process phosphatidylinositol 5-phosphate metabolic process;GO:2000785,biological_process regulation of autophagosome assembly	PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]; K00921	phosphoinositide kinase%2C FYVE-type zinc finger containing [Source:HGNC Symbol%3BAcc:HGNC:23785]
ENSG00000175104	7.53	6.22	7.47	6.93	7.02	7.72	-0.00912918626162121	3.51167745397122	0.933865472245646	0.992751534971647	11:36487026-36510272:-	TRAF6	88;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000187,biological_process activation of MAPK activity;GO:0000209,biological_process protein polyubiquitination;GO:0001503,biological_process ossification;GO:0001843,biological_process neural tube closure;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0002376,biological_process immune system process;GO:0002726,biological_process positive regulation of T cell cytokine production;GO:0002755,biological_process MyD88-dependent toll-like receptor signaling pathway;GO:0002756,biological_process MyD88-independent toll-like receptor signaling pathway;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006461,biological_process protein complex assembly;GO:0006955,biological_process immune response;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0007254,biological_process JNK cascade;GO:0008270,molecular_function zinc ion binding;GO:0009887,biological_process organ morphogenesis;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010008,cellular_component endosome membrane;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0019901,molecular_function protein kinase binding;GO:0030316,biological_process osteoclast differentiation;GO:0031293,biological_process membrane protein intracellular domain proteolysis;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031666,biological_process positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0031996,molecular_function thioesterase binding;GO:0032147,biological_process activation of protein kinase activity;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0035631,cellular_component CD40 receptor complex;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042088,biological_process T-helper 1 type immune response;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042802,molecular_function identical protein binding;GO:0042826,molecular_function histone deacetylase binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043011,biological_process myeloid dendritic cell differentiation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043422,molecular_function protein kinase B binding;GO:0043507,biological_process positive regulation of JUN kinase activity;GO:0045084,biological_process positive regulation of interleukin-12 biosynthetic process;GO:0045410,biological_process positive regulation of interleukin-6 biosynthetic process;GO:0045453,biological_process bone resorption;GO:0045672,biological_process positive regulation of osteoclast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046849,biological_process bone remodeling;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0048468,biological_process cell development;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050870,biological_process positive regulation of T cell activation;GO:0051023,biological_process regulation of immunoglobulin secretion;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070498,biological_process interleukin-1-mediated signaling pathway;GO:0070534,biological_process protein K63-linked ubiquitination;GO:0070555,biological_process response to interleukin-1;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:2000679,biological_process positive regulation of transcription regulatory region DNA binding	TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]; K03175	TNF receptor associated factor 6 [Source:HGNC Symbol%3BAcc:HGNC:12036]
ENSG00000149926	1.12	1.52	1.17	1.61	0.57	1.45	0.0586092657642977	0.555572397514174	0.933892303651069	0.992751534971647	16:30024426-30052978:-	FAM57B	10;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0046513,biological_process ceramide biosynthetic process;GO:0050291,molecular_function sphingosine N-acyltransferase activity	NA	family with sequence similarity 57 member B [Source:HGNC Symbol%3BAcc:HGNC:25295]
ENSG00000179862	3.33	2.42	3.07	2.71	2.89	3.06	0.0568500866009822	0.825871468338499	0.93395595871489	0.992751534971647	1:40861050-40862366:-	CITED4	12;GO:0001105,molecular_function RNA polymerase II transcription coactivator activity;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0032502,biological_process developmental process;GO:0043627,biological_process response to estrogen;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 [Source:HGNC Symbol%3BAcc:HGNC:18696]
ENSG00000108256	31.30	33.00	34.03	30.45	36.19	32.95	-0.00693919029010593	6.10767287610249	0.933968615596463	0.992751534971647	17:29255835-29294118:-	NUFIP2	10;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0042788,cellular_component polysomal ribosome	NA	NUFIP2%2C FMR1 interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:17634]
ENSG00000179091	113.94	109.39	101.61	107.74	110.85	107.68	0.00579127181562894	6.72835358807594	0.934294456769403	0.992906211412197	8:144095026-144097525:+	CYC1	16;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0009055,molecular_function electron carrier activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0020037,molecular_function heme binding;GO:0033762,biological_process response to glucagon;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0045153,molecular_function electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity;GO:0045155,molecular_function electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit; K00413	cytochrome c1 [Source:HGNC Symbol%3BAcc:HGNC:2579]
ENSG00000205629	26.14	23.79	23.39	24.12	22.91	26.53	0.0080909677335849	5.10138434585297	0.934346691218492	0.992906211412197	16:25111728-25178231:+	LCMT1	18;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003880,molecular_function protein C-terminal carboxyl O-methyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006479,biological_process protein methylation;GO:0006481,biological_process C-terminal protein methylation;GO:0008168,molecular_function methyltransferase activity;GO:0008276,molecular_function protein methyltransferase activity;GO:0008757,molecular_function S-adenosylmethionine-dependent methyltransferase activity;GO:0010906,biological_process regulation of glucose metabolic process;GO:0016740,molecular_function transferase activity;GO:0018423,molecular_function protein C-terminal leucine carboxyl O-methyltransferase activity;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0032259,biological_process methylation;GO:0042981,biological_process regulation of apoptotic process;GO:0090266,biological_process regulation of mitotic cell cycle spindle assembly checkpoint	NA	leucine carboxyl methyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:17557]
ENSG00000023909	88.50	82.31	86.41	86.90	79.53	91.88	0.00674263909043598	6.14705686930463	0.934354100983313	0.992906211412197	1:93885204-93909456:-	GCLM	30;GO:0004357,molecular_function glutamate-cysteine ligase activity;GO:0005829,cellular_component cytosol;GO:0006534,biological_process cysteine metabolic process;GO:0006536,biological_process glutamate metabolic process;GO:0006749,biological_process glutathione metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0006979,biological_process response to oxidative stress;GO:0007568,biological_process aging;GO:0007584,biological_process response to nutrient;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0014823,biological_process response to activity;GO:0017109,cellular_component glutamate-cysteine ligase complex;GO:0030234,molecular_function enzyme regulator activity;GO:0035226,molecular_function glutamate-cysteine ligase catalytic subunit binding;GO:0035229,biological_process positive regulation of glutamate-cysteine ligase activity;GO:0035729,biological_process cellular response to hepatocyte growth factor stimulus;GO:0035733,biological_process hepatic stellate cell activation;GO:0042493,biological_process response to drug;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0044344,biological_process cellular response to fibroblast growth factor stimulus;GO:0044752,biological_process response to human chorionic gonadotropin;GO:0046982,molecular_function protein heterodimerization activity;GO:0050880,biological_process regulation of blood vessel size;GO:0051409,biological_process response to nitrosative stress;GO:0051900,biological_process regulation of mitochondrial depolarization;GO:0071333,biological_process cellular response to glucose stimulus;GO:0071372,biological_process cellular response to follicle-stimulating hormone stimulus;GO:0097069,biological_process cellular response to thyroxine stimulus;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	GCLM; glutamate--cysteine ligase regulatory subunit; K11205	glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol%3BAcc:HGNC:4312]
ENSG00000066827	2.28	2.97	2.57	2.73	2.63	2.58	-0.0223537052514946	3.43971149188534	0.934508935200132	0.992985739825308	8:134477787-134713049:-	ZFAT	14;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0030097,biological_process hemopoiesis;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060712,biological_process spongiotrophoblast layer development	NA	zinc finger and AT-hook domain containing [Source:HGNC Symbol%3BAcc:HGNC:19899]
ENSG00000158985	30.89	31.86	34.54	30.95	34.99	31.50	0.0111621429275511	3.62381079406734	0.934781307521891	0.993183558091441	5:131245492-131398447:+	CDC42SE2	12;GO:0001891,cellular_component phagocytic cup;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006909,biological_process phagocytosis;GO:0008360,biological_process regulation of cell shape;GO:0009966,biological_process regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0042995,cellular_component cell projection;GO:0070062,cellular_component extracellular exosome	NA	CDC42 small effector 2 [Source:HGNC Symbol%3BAcc:HGNC:18547]
ENSG00000104067	25.55	23.86	23.26	24.55	24.69	24.31	-0.00513564503391362	7.1427254560236	0.934868520950368	0.993183558091441	15:29699366-29968865:-	TJP1	39;GO:0001825,biological_process blastocyst formation;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005912,cellular_component adherens junction;GO:0005913,cellular_component cell-cell adherens junction;GO:0005921,cellular_component gap junction;GO:0005923,cellular_component bicellular tight junction;GO:0007043,biological_process cell-cell junction assembly;GO:0007605,biological_process sensory perception of sound;GO:0008022,molecular_function protein C-terminus binding;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016327,cellular_component apicolateral plasma membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0032496,biological_process response to lipopolysaccharide;GO:0035329,biological_process hippo signaling;GO:0042493,biological_process response to drug;GO:0043116,biological_process negative regulation of vascular permeability;GO:0043234,cellular_component protein complex;GO:0043296,cellular_component apical junction complex;GO:0045177,cellular_component apical part of cell;GO:0045296,molecular_function cadherin binding;GO:0045471,biological_process response to ethanol;GO:0046581,cellular_component intercellular canaliculus;GO:0070160,cellular_component occluding junction;GO:0071000,biological_process response to magnetism;GO:0071253,molecular_function connexin binding;GO:0071333,biological_process cellular response to glucose stimulus;GO:0090557,biological_process establishment of endothelial intestinal barrier;GO:1901350,biological_process cell-cell signaling involved in cell-cell junction organization;GO:2000810,biological_process regulation of bicellular tight junction assembly	TJP1, ZO1; tight junction protein 1; K05701	tight junction protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11827]
ENSG00000180228	56.89	56.83	52.02	57.93	53.60	56.21	-0.00709203597491198	5.76006670376037	0.934997725734688	0.993183558091441	2:178431413-178451512:-	PRKRA	33;GO:0003723,molecular_function RNA binding;GO:0003725,molecular_function double-stranded RNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006955,biological_process immune response;GO:0008047,molecular_function enzyme activator activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009615,biological_process response to virus;GO:0010586,biological_process miRNA metabolic process;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019899,molecular_function enzyme binding;GO:0030422,biological_process production of siRNA involved in RNA interference;GO:0031047,biological_process gene silencing by RNA;GO:0031054,biological_process pre-miRNA processing;GO:0034599,biological_process cellular response to oxidative stress;GO:0035196,biological_process production of miRNAs involved in gene silencing by miRNA;GO:0042473,biological_process outer ear morphogenesis;GO:0042474,biological_process middle ear morphogenesis;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043085,biological_process positive regulation of catalytic activity;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048705,biological_process skeletal system morphogenesis;GO:0050821,biological_process protein stabilization;GO:0070578,cellular_component RISC-loading complex;GO:0070883,molecular_function pre-miRNA binding;GO:2001244,biological_process positive regulation of intrinsic apoptotic signaling pathway	NA	protein activator of interferon induced protein kinase EIF2AK2 [Source:HGNC Symbol%3BAcc:HGNC:9438]
ENSG00000001629	31.94	31.56	34.05	32.65	33.71	32.41	-0.00510252749432227	6.77381069954271	0.935015150234156	0.993183558091441	7:92246233-92401384:+	ANKIB1	12;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ankyrin repeat and IBR domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:22215]
ENSG00000093000	24.43	22.60	23.60	24.38	22.73	23.83	0.00854688752537532	5.08006350252032	0.935109548919104	0.993198838943514	22:45163840-45188015:+	NUP50	25;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006606,biological_process protein import into nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043657,cellular_component host cell;GO:0046907,biological_process intracellular transport;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP50, NPAP60; nuclear pore complex protein Nup50; K14295	nucleoporin 50 [Source:HGNC Symbol%3BAcc:HGNC:8065]
ENSG00000108839	5.15	5.38	6.25	5.83	5.95	5.30	-0.0106755323913758	3.50957324821896	0.935220161228569	0.993231336527227	17:6996064-7010736:+	ALOX12	52;GO:0004052,molecular_function arachidonate 12-lipoxygenase activity;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006928,biological_process movement of cell or subcellular component;GO:0007568,biological_process aging;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010628,biological_process positive regulation of gene expression;GO:0010656,biological_process negative regulation of muscle cell apoptotic process;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016165,molecular_function linoleate 13S-lipoxygenase activity;GO:0016491,molecular_function oxidoreductase activity;GO:0016702,molecular_function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0016787,molecular_function hydrolase activity;GO:0019369,biological_process arachidonic acid metabolic process;GO:0019372,biological_process lipoxygenase pathway;GO:0019395,biological_process fatty acid oxidation;GO:0030307,biological_process positive regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0042383,cellular_component sarcolemma;GO:0042554,biological_process superoxide anion generation;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043651,biological_process linoleic acid metabolic process;GO:0045603,biological_process positive regulation of endothelial cell differentiation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0045785,biological_process positive regulation of cell adhesion;GO:0046872,molecular_function metal ion binding;GO:0047977,molecular_function hepoxilin-epoxide hydrolase activity;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0051120,molecular_function hepoxilin A3 synthase activity;GO:0051121,biological_process hepoxilin metabolic process;GO:0051122,biological_process hepoxilin biosynthetic process;GO:0051213,molecular_function dioxygenase activity;GO:0051901,biological_process positive regulation of mitochondrial depolarization;GO:0055114,biological_process oxidation-reduction process;GO:0061436,biological_process establishment of skin barrier;GO:0070062,cellular_component extracellular exosome;GO:0071396,biological_process cellular response to lipid;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090331,biological_process negative regulation of platelet aggregation;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1901751,biological_process leukotriene A4 metabolic process;GO:2001300,biological_process lipoxin metabolic process;GO:2001303,biological_process lipoxin A4 biosynthetic process;GO:2001306,biological_process lipoxin B4 biosynthetic process	ALOX12; arachidonate 12-lipoxygenase [EC:1.13.11.31]; K00458	arachidonate 12-lipoxygenase%2C 12S type [Source:HGNC Symbol%3BAcc:HGNC:429]
ENSG00000185101	0.60	0.73	0.63	0.45	0.81	0.78	-0.0554301688457201	0.774264844194579	0.935348555615944	0.993280958496689	11:417932-442011:-	ANO9	17;GO:0005229,molecular_function intracellular calcium activated chloride channel activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006821,biological_process chloride transport;GO:0006869,biological_process lipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017128,molecular_function phospholipid scramblase activity;GO:0034220,biological_process ion transmembrane transport;GO:0061588,biological_process calcium activated phospholipid scrambling;GO:0061589,biological_process calcium activated phosphatidylserine scrambling;GO:0061590,biological_process calcium activated phosphatidylcholine scrambling;GO:0061591,biological_process calcium activated galactosylceramide scrambling;GO:1902476,biological_process chloride transmembrane transport;GO:1902939,biological_process negative regulation of intracellular calcium activated chloride channel activity	NA	anoctamin 9 [Source:HGNC Symbol%3BAcc:HGNC:20679]
ENSG00000065328	3.39	4.47	3.83	4.04	3.64	4.19	-0.0240552284658755	3.39470272873775	0.935455806929251	0.993280958496689	10:13161553-13211104:+	MCM10	16;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003688,molecular_function DNA replication origin binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008283,biological_process cell proliferation;GO:0019899,molecular_function enzyme binding;GO:0031298,cellular_component replication fork protection complex;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	NA	minichromosome maintenance 10 replication initiation factor [Source:HGNC Symbol%3BAcc:HGNC:18043]
ENSG00000107175	45.75	41.39	39.61	40.56	43.47	43.21	0.00749738517101662	5.56438207366396	0.935506943187368	0.993280958496689	9:35732334-35737004:+	CREB3	28;GO:0000139,cellular_component Golgi membrane;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006935,biological_process chemotaxis;GO:0006986,biological_process response to unfolded protein;GO:0006990,biological_process positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0035497,molecular_function cAMP response element binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0090026,biological_process positive regulation of monocyte chemotaxis;GO:1902236,biological_process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	CREB3; cyclic AMP-responsive element-binding protein 3; K09048	cAMP responsive element binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:2347]
ENSG00000196873	3.49	3.94	3.63	4.42	2.64	4.21	-0.0240781167252867	2.24809933429389	0.936025740156065	0.993679258752441	9:68232002-68300015:+	CBWD3	2;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding	NA	COBW domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:18519]
ENSG00000144591	24.09	28.74	25.81	26.41	27.22	25.09	0.00484692826336103	5.26254182997148	0.936042179375839	0.993679258752441	2:219498866-219506989:+	GMPPA	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0009058,biological_process biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0070062,cellular_component extracellular exosome	GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]; K00966	GDP-mannose pyrophosphorylase A [Source:HGNC Symbol%3BAcc:HGNC:22923]
ENSG00000112852	0.56	0.72	0.80	0.66	0.70	0.79	-0.0449183469152469	0.877229708325692	0.936167960310492	0.993727799840443	5:141094577-141098703:+	PCDHB2	11;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007268,biological_process chemical synaptic transmission;GO:0007399,biological_process nervous system development;GO:0007416,biological_process synapse assembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016339,biological_process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NA	protocadherin beta 2 [Source:HGNC Symbol%3BAcc:HGNC:8687]
ENSG00000053770	20.94	26.28	21.34	24.00	24.80	19.75	0.0072369419009071	5.13743215813224	0.936812682707022	0.994269780622498	14:57268908-57298742:+	AP5M1	12;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0030119,cellular_component AP-type membrane coat adaptor complex;GO:0031902,cellular_component late endosome membrane	NA	adaptor related protein complex 5 mu 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:20192]
ENSG00000185829	1.52	2.05	2.11	1.16	2.35	2.01	0.0380433041545851	0.774424287552621	0.93687988989026	0.994269780622498	17:46516701-46579682:-	ARL17A	8;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport	NA	ADP ribosylation factor like GTPase 17A [Source:HGNC Symbol%3BAcc:HGNC:24096]
ENSG00000129521	36.32	27.95	39.67	38.32	30.36	37.12	-0.00759367095511471	4.83301975304407	0.936918845077045	0.994269780622498	14:33924230-34462774:-	EGLN3	23;GO:0001666,biological_process response to hypoxia;GO:0005506,molecular_function iron ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016491,molecular_function oxidoreductase activity;GO:0016705,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0018126,biological_process protein hydroxylation;GO:0018401,biological_process peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0031418,molecular_function L-ascorbic acid binding;GO:0031545,molecular_function peptidyl-proline 4-dioxygenase activity;GO:0042127,biological_process regulation of cell proliferation;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia	EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]; K09592	egl-9 family hypoxia inducible factor 3 [Source:HGNC Symbol%3BAcc:HGNC:14661]
ENSG00000162004	4.96	4.20	4.54	4.94	4.36	4.39	0.0231716320221169	2.72432842228427	0.937124875864277	0.994283816089436	16:722581-726954:-	CCDC78	12;GO:0003009,biological_process skeletal muscle contraction;GO:0005737,cellular_component cytoplasm;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0030030,biological_process cell projection organization;GO:0042383,cellular_component sarcolemma;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0098535,biological_process de novo centriole assembly;GO:0098536,cellular_component deuterosome	NA	coiled-coil domain containing 78 [Source:HGNC Symbol%3BAcc:HGNC:14153]
ENSG00000198429	4.78	5.57	4.94	3.97	6.21	5.43	-0.0228827686823546	3.14973991540413	0.937185837423232	0.994283816089436	19:11887783-11914329:+	ZNF69	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 69 [Source:HGNC Symbol%3BAcc:HGNC:13138]
ENSG00000278615	14.13	15.68	12.90	14.81	14.66	12.96	0.0135363146837337	2.68740417228414	0.93722574734469	0.994283816089436	11:62662815-62665217:-	C11orf98	NA	NA	chromosome 11 open reading frame 98 [Source:HGNC Symbol%3BAcc:HGNC:51238]
ENSG00000111361	27.55	28.60	27.87	28.49	27.66	28.10	0.00581009122887896	5.01330950538114	0.937428200223447	0.994283816089436	12:123620405-123633766:-	EIF2B1	18;GO:0003743,molecular_function translation initiation factor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005851,cellular_component eukaryotic translation initiation factor 2B complex;GO:0005886,cellular_component plasma membrane;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0009408,biological_process response to heat;GO:0009749,biological_process response to glucose;GO:0014003,biological_process oligodendrocyte development;GO:0016020,cellular_component membrane;GO:0042802,molecular_function identical protein binding;GO:0043434,biological_process response to peptide hormone;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044237,biological_process cellular metabolic process;GO:0051716,biological_process cellular response to stimulus	EIF2B1; translation initiation factor eIF-2B subunit alpha; K03239	eukaryotic translation initiation factor 2B subunit alpha [Source:HGNC Symbol%3BAcc:HGNC:3257]
ENSG00000106829	9.60	8.78	8.91	9.82	8.83	9.05	-0.00640766247486377	4.67917839361647	0.937497991494411	0.994283816089436	9:79571772-79726882:+	TLE4	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003674,molecular_function molecular_function;GO:0003682,molecular_function chromatin binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0016055,biological_process Wnt signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0070491,molecular_function repressing transcription factor binding;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	transducin like enhancer of split 4 [Source:HGNC Symbol%3BAcc:HGNC:11840]
ENSG00000173542	13.77	9.03	11.63	12.83	12.66	8.93	0.0276146352113614	2.99454344563441	0.937515171031516	0.994283816089436	4:70902325-71022449:+	MOB1B	12;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0019209,molecular_function kinase activator activity;GO:0019900,molecular_function kinase binding;GO:0031952,biological_process regulation of protein autophosphorylation;GO:0035329,biological_process hippo signaling;GO:0042327,biological_process positive regulation of phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	MOB1, Mats; MOB kinase activator 1; K06685	MOB kinase activator 1B [Source:HGNC Symbol%3BAcc:HGNC:29801]
ENSG00000119969	6.94	6.08	6.86	7.30	6.03	6.88	-0.00663621705916568	4.23119658720617	0.937609352797957	0.994283816089436	10:94501433-94613905:+	HELLS	24;GO:0000166,molecular_function nucleotide binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0001655,biological_process urogenital system development;GO:0003682,molecular_function chromatin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005721,cellular_component pericentric heterochromatin;GO:0006306,biological_process DNA methylation;GO:0006342,biological_process chromatin silencing;GO:0006346,biological_process methylation-dependent chromatin silencing;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007275,biological_process multicellular organism development;GO:0010216,biological_process maintenance of DNA methylation;GO:0016787,molecular_function hydrolase activity;GO:0031508,biological_process pericentric heterochromatin assembly;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046651,biological_process lymphocyte proliferation;GO:0051301,biological_process cell division;GO:1990830,biological_process cellular response to leukemia inhibitory factor;GO:2001243,biological_process negative regulation of intrinsic apoptotic signaling pathway	NA	helicase%2C lymphoid specific [Source:HGNC Symbol%3BAcc:HGNC:4861]
ENSG00000163072	1.08	0.99	0.72	0.94	1.08	0.88	-0.0426603906705736	0.916571058530557	0.937611081807214	0.994283816089436	2:168786538-168865514:+	NOSTRIN	13;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006897,biological_process endocytosis;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0030666,cellular_component endocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0050999,biological_process regulation of nitric-oxide synthase activity	NA	nitric oxide synthase trafficking [Source:HGNC Symbol%3BAcc:HGNC:20203]
ENSG00000105135	40.97	36.91	39.75	37.91	41.08	39.23	0.00711851925927674	6.22599065933614	0.937657374874318	0.994283816089436	19:15114983-15125785:-	ILVBL	10;GO:0000287,molecular_function magnesium ion binding;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005515,molecular_function protein binding;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030976,molecular_function thiamine pyrophosphate binding;GO:0046872,molecular_function metal ion binding	NA	ilvB acetolactate synthase like [Source:HGNC Symbol%3BAcc:HGNC:6041]
ENSG00000185163	4.31	5.74	5.71	4.87	5.47	5.35	0.00992830941768564	3.40494426384072	0.937775953294431	0.994283816089436	12:132136593-132144335:-	DDX51	14;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006364,biological_process rRNA processing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0042254,biological_process ribosome biogenesis	NA	DEAD-box helicase 51 [Source:HGNC Symbol%3BAcc:HGNC:20082]
ENSG00000167220	28.01	25.97	25.04	26.85	27.48	25.82	-0.0061963905410113	4.44931326484474	0.937920131901329	0.994283816089436	18:47107402-47150520:-	HDHD2	7;GO:0005515,molecular_function protein binding;GO:0008150,biological_process biological_process;GO:0016311,biological_process dephosphorylation;GO:0016791,molecular_function phosphatase activity;GO:0019899,molecular_function enzyme binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	NA	haloacid dehalogenase like hydrolase domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25364]
ENSG00000141391	10.60	9.04	9.05	10.62	7.08	11.64	-0.0196428396292038	3.06580626871641	0.938000325420869	0.994283816089436	18:12407895-12432238:+	PRELID3A	8;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0015914,biological_process phospholipid transport;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion;GO:1990050,molecular_function phosphatidic acid transporter activity	NA	PRELI domain containing 3A [Source:HGNC Symbol%3BAcc:HGNC:24639]
ENSG00000148187	27.31	25.48	26.74	26.54	27.39	26.80	-0.0060009932569973	4.59856334121152	0.938000895300912	0.994283816089436	9:122264602-122331343:+	MRRF	6;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0032790,biological_process ribosome disassembly;GO:0043023,molecular_function ribosomal large subunit binding;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosome recycling factor [Source:HGNC Symbol%3BAcc:HGNC:7234]
ENSG00000161048	9.94	11.67	8.55	10.41	11.84	7.75	0.0144320713075201	3.57352192938201	0.938053473795487	0.994283816089436	7:103099775-103149560:-	NAPEPLD	19;GO:0001523,biological_process retinoid metabolic process;GO:0004620,molecular_function phospholipase activity;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0007568,biological_process aging;GO:0008270,molecular_function zinc ion binding;GO:0009395,biological_process phospholipid catabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0035900,biological_process response to isolation stress;GO:0042622,cellular_component photoreceptor outer segment membrane;GO:0043227,cellular_component membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070290,molecular_function N-acylphosphatidylethanolamine-specific phospholipase D activity;GO:0102200,molecular_function N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity;GO:1903999,biological_process negative regulation of eating behavior	NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D [EC:3.1.4.54]; K13985	N-acyl phosphatidylethanolamine phospholipase D [Source:HGNC Symbol%3BAcc:HGNC:21683]
ENSG00000198298	0.96	1.30	1.39	1.13	1.66	0.96	-0.0298266790198363	0.827195830718804	0.938150347597407	0.994301593641275	10:43606406-43617903:+	ZNF485	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 485 [Source:HGNC Symbol%3BAcc:HGNC:23440]
ENSG00000149054	3.62	3.40	4.04	4.20	3.25	3.60	0.0191717966388328	2.6508180907672	0.9383912909391	0.994429839474074	11:6926403-7001004:+	ZNF215	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 215 [Source:HGNC Symbol%3BAcc:HGNC:13007]
ENSG00000174574	36.05	38.66	35.91	37.70	34.63	39.55	-0.0101745979017686	4.4267342126788	0.93849724264873	0.994429839474074	1:38991222-39006059:+	AKIRIN1	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0031965,cellular_component nuclear membrane	NA	akirin 1 [Source:HGNC Symbol%3BAcc:HGNC:25744]
ENSG00000159885	3.12	4.09	3.30	3.85	3.80	2.73	0.0177940018974667	2.4105695078196	0.938511686895898	0.994429839474074	19:44025341-44033112:+	ZNF222	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 222 [Source:HGNC Symbol%3BAcc:HGNC:13015]
ENSG00000145293	51.32	55.29	58.56	56.13	53.37	56.22	0.00581567185687767	5.43805073751443	0.93896364077703	0.994823802745414	4:82430561-82461091:+	ENOPH1	13;GO:0000287,molecular_function magnesium ion binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008152,biological_process metabolic process;GO:0008652,biological_process cellular amino acid biosynthetic process;GO:0009086,biological_process methionine biosynthetic process;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0019509,biological_process L-methionine biosynthetic process from methylthioadenosine;GO:0043874,molecular_function acireductone synthase activity;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	mtnC, ENOPH1; enolase-phosphatase E1 [EC:3.1.3.77]; K09880	enolase-phosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:24599]
ENSG00000145882	7.26	7.78	8.34	6.87	8.69	7.83	0.0106254983144331	3.6000513444669	0.939076542022414	0.99483062642143	5:149358006-149369653:+	PCYOX1L	11;GO:0001735,molecular_function prenylcysteine oxidase activity;GO:0002576,biological_process platelet degranulation;GO:0005576,cellular_component extracellular region;GO:0005774,cellular_component vacuolar membrane;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0016670,molecular_function oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor;GO:0030327,biological_process prenylated protein catabolic process;GO:0030328,biological_process prenylcysteine catabolic process;GO:0031093,cellular_component platelet alpha granule lumen;GO:0055114,biological_process oxidation-reduction process	NA	prenylcysteine oxidase 1 like [Source:HGNC Symbol%3BAcc:HGNC:28477]
ENSG00000108666	28.32	31.29	28.92	28.57	27.34	32.74	0.00470794371854447	5.19670069298955	0.939130369806358	0.99483062642143	17:32324564-32350023:-	C17orf75	2;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component	NA	chromosome 17 open reading frame 75 [Source:HGNC Symbol%3BAcc:HGNC:30173]
ENSG00000132661	41.53	35.95	41.71	43.50	33.95	43.87	-0.00913217607960174	4.09193179471176	0.939566067283794	0.995207235531508	20:23350735-23354777:+	NXT1	14;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0016607,cellular_component nuclear speck	NXT1_2, P15; NTF2-related export protein 1/2; K14285	nuclear transport factor 2 like export factor 1 [Source:HGNC Symbol%3BAcc:HGNC:15913]
ENSG00000171236	1.97	2.02	1.27	1.58	1.89	1.69	0.0255943563862228	0.964501806720344	0.93966005245876	0.995221862727866	19:4536408-4540474:-	LRG1	16;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0003674,molecular_function molecular_function;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0030511,biological_process positive regulation of transforming growth factor beta receptor signaling pathway;GO:0035580,cellular_component specific granule lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0045766,biological_process positive regulation of angiogenesis;GO:0050873,biological_process brown fat cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	NA	leucine rich alpha-2-glycoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:29480]
ENSG00000135424	0.45	0.15	0.37	0.24	0.56	0.24	-0.0420715960742864	0.529038221942925	0.940102003259689	0.995604996712099	12:55684567-55716043:-	ITGA7	15;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007517,biological_process muscle organ development;GO:0008305,cellular_component integrin complex;GO:0008360,biological_process regulation of cell shape;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0035987,biological_process endodermal cell differentiation;GO:0046872,molecular_function metal ion binding	ITGA7; integrin alpha 7; K06583	integrin subunit alpha 7 [Source:HGNC Symbol%3BAcc:HGNC:6143]
ENSG00000109654	2.44	1.84	2.52	2.13	2.22	2.65	-0.0157066735583758	2.62838271266943	0.940388994151501	0.99567391716201	4:153152341-153339320:+	TRIM2	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0043523,biological_process regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 2 [Source:HGNC Symbol%3BAcc:HGNC:15974]
ENSG00000187650	3.48	2.45	3.48	2.66	2.39	4.72	-0.0303647520108099	0.845643951072148	0.94047806742594	0.99567391716201	19:5904857-5910853:+	VMAC	1;GO:0005737,cellular_component cytoplasm	NA	vimentin type intermediate filament associated coiled-coil protein [Source:HGNC Symbol%3BAcc:HGNC:33803]
ENSG00000142168	464.27	523.75	417.39	468.03	495.11	459.35	-0.00675271775701112	7.76770189177937	0.940503653142969	0.99567391716201	21:31659621-31668931:+	SOD1	101;GO:0000187,biological_process activation of MAPK activity;GO:0000302,biological_process response to reactive oxygen species;GO:0000303,biological_process response to superoxide;GO:0001541,biological_process ovarian follicle development;GO:0001819,biological_process positive regulation of cytokine production;GO:0001890,biological_process placenta development;GO:0001895,biological_process retina homeostasis;GO:0001975,biological_process response to amphetamine;GO:0002262,biological_process myeloid cell homeostasis;GO:0002576,biological_process platelet degranulation;GO:0004784,molecular_function superoxide dismutase activity;GO:0005507,molecular_function copper ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0005759,cellular_component mitochondrial matrix;GO:0005764,cellular_component lysosome;GO:0005777,cellular_component peroxisome;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006749,biological_process glutathione metabolic process;GO:0006801,biological_process superoxide metabolic process;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006979,biological_process response to oxidative stress;GO:0007283,biological_process spermatogenesis;GO:0007566,biological_process embryo implantation;GO:0007568,biological_process aging;GO:0007569,biological_process cell aging;GO:0007605,biological_process sensory perception of sound;GO:0007626,biological_process locomotory behavior;GO:0008089,biological_process anterograde axonal transport;GO:0008090,biological_process retrograde axonal transport;GO:0008217,biological_process regulation of blood pressure;GO:0008270,molecular_function zinc ion binding;GO:0009408,biological_process response to heat;GO:0010033,biological_process response to organic substance;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019226,biological_process transmission of nerve impulse;GO:0019430,biological_process removal of superoxide radicals;GO:0019899,molecular_function enzyme binding;GO:0030141,cellular_component secretory granule;GO:0030346,molecular_function protein phosphatase 2B binding;GO:0031012,cellular_component extracellular matrix;GO:0031045,cellular_component dense core granule;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031667,biological_process response to nutrient levels;GO:0032287,biological_process peripheral nervous system myelin maintenance;GO:0032839,cellular_component dendrite cytoplasm;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0033081,biological_process regulation of T cell differentiation in thymus;GO:0034465,biological_process response to carbon monoxide;GO:0034599,biological_process cellular response to oxidative stress;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0035865,biological_process cellular response to potassium ion;GO:0040014,biological_process regulation of multicellular organism growth;GO:0042493,biological_process response to drug;GO:0042542,biological_process response to hydrogen peroxide;GO:0042554,biological_process superoxide anion generation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043087,biological_process regulation of GTPase activity;GO:0043209,cellular_component myelin sheath;GO:0043234,cellular_component protein complex;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0045471,biological_process response to ethanol;GO:0045541,biological_process negative regulation of cholesterol biosynthetic process;GO:0045859,biological_process regulation of protein kinase activity;GO:0046620,biological_process regulation of organ growth;GO:0046677,biological_process response to antibiotic;GO:0046688,biological_process response to copper ion;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0046872,molecular_function metal ion binding;GO:0048365,molecular_function Rac GTPase binding;GO:0048538,biological_process thymus development;GO:0048678,biological_process response to axon injury;GO:0050665,biological_process hydrogen peroxide biosynthetic process;GO:0051087,molecular_function chaperone binding;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0055114,biological_process oxidation-reduction process;GO:0060047,biological_process heart contraction;GO:0060052,biological_process neurofilament cytoskeleton organization;GO:0060087,biological_process relaxation of vascular smooth muscle;GO:0060088,biological_process auditory receptor cell stereocilium organization;GO:0070062,cellular_component extracellular exosome;GO:0071276,biological_process cellular response to cadmium ion;GO:0071318,biological_process cellular response to ATP;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0097332,biological_process response to antipsychotic drug;GO:1902177,biological_process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1904115,cellular_component axon cytoplasm	SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]; K04565	superoxide dismutase 1 [Source:HGNC Symbol%3BAcc:HGNC:11179]
ENSG00000167393	6.79	7.00	6.48	6.44	6.41	7.69	-0.0123735554708015	3.75769746952111	0.940563267599856	0.99567391716201	X:333962-386955:-	PPP2R3B	12;GO:0000159,cellular_component protein phosphatase type 2A complex;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006470,biological_process protein dephosphorylation;GO:0007050,biological_process cell cycle arrest;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0046872,molecular_function metal ion binding;GO:0050790,biological_process regulation of catalytic activity	PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''; K11583	protein phosphatase 2 regulatory subunit B''beta [Source:HGNC Symbol%3BAcc:HGNC:13417]
ENSG00000189241	46.92	44.32	44.46	45.29	49.69	42.48	-0.00506212517943816	5.90409073078104	0.940607604320596	0.99567391716201	6:116276577-116279903:-	TSPYL1	5;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006334,biological_process nucleosome assembly;GO:0008150,biological_process biological_process;GO:0019899,molecular_function enzyme binding	NA	TSPY like 1 [Source:HGNC Symbol%3BAcc:HGNC:12382]
ENSG00000174437	74.37	75.27	76.35	77.47	75.34	75.74	-0.00450728696654794	7.90740095565476	0.940763578064163	0.99567391716201	12:110280755-110351093:+	ATP2A2	55;GO:0000166,molecular_function nucleotide binding;GO:0002026,biological_process regulation of the force of heart contraction;GO:0005388,molecular_function calcium-transporting ATPase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006816,biological_process calcium ion transport;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006984,biological_process ER-nucleus signaling pathway;GO:0006996,biological_process organelle organization;GO:0007155,biological_process cell adhesion;GO:0008544,biological_process epidermis development;GO:0010460,biological_process positive regulation of heart rate;GO:0010882,biological_process regulation of cardiac muscle contraction by calcium ion signaling;GO:0012506,cellular_component vesicle membrane;GO:0014883,biological_process transition between fast and slow fiber;GO:0014898,biological_process cardiac muscle hypertrophy in response to stress;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016787,molecular_function hydrolase activity;GO:0019899,molecular_function enzyme binding;GO:0031095,cellular_component platelet dense tubular network membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031775,molecular_function lutropin-choriogonadotropic hormone receptor binding;GO:0032469,biological_process endoplasmic reticulum calcium ion homeostasis;GO:0032470,biological_process positive regulation of endoplasmic reticulum calcium ion concentration;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0033292,biological_process T-tubule organization;GO:0034220,biological_process ion transmembrane transport;GO:0034599,biological_process cellular response to oxidative stress;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0043234,cellular_component protein complex;GO:0044548,molecular_function S100 protein binding;GO:0045822,biological_process negative regulation of heart contraction;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055119,biological_process relaxation of cardiac muscle;GO:0070296,biological_process sarcoplasmic reticulum calcium ion transport;GO:0070588,biological_process calcium ion transmembrane transport;GO:0086036,biological_process regulation of cardiac muscle cell membrane potential;GO:0086039,molecular_function calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential;GO:0097470,cellular_component ribbon synapse;GO:0098909,biological_process regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:0099132,biological_process ATP hydrolysis coupled cation transmembrane transport;GO:1903233,biological_process regulation of calcium ion-dependent exocytosis of neurotransmitter;GO:1903515,biological_process calcium ion transport from cytosol to endoplasmic reticulum;GO:1903779,biological_process regulation of cardiac conduction;GO:1990036,biological_process calcium ion import into sarcoplasmic reticulum	ATP2A; P-type Ca2+ transporter type 2A [EC:7.2.2.10]; K05853	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [Source:HGNC Symbol%3BAcc:HGNC:812]
ENSG00000176845	20.44	16.06	16.05	17.52	16.14	19.82	-0.0091224086531457	4.07320059144018	0.940801736074744	0.99567391716201	17:83079690-83095119:+	METRNL	12;GO:0003674,molecular_function molecular_function;GO:0005179,molecular_function hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0009409,biological_process response to cold;GO:0014850,biological_process response to muscle activity;GO:0045444,biological_process fat cell differentiation;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050873,biological_process brown fat cell differentiation;GO:0070062,cellular_component extracellular exosome;GO:0090336,biological_process positive regulation of brown fat cell differentiation;GO:2000507,biological_process positive regulation of energy homeostasis	NA	meteorin like%2C glial cell differentiation regulator [Source:HGNC Symbol%3BAcc:HGNC:27584]
ENSG00000197937	5.62	5.37	6.24	5.93	5.89	5.71	-0.00687538603624015	3.88860581720664	0.940808779053671	0.99567391716201	19:53124071-53159075:-	ZNF347	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 347 [Source:HGNC Symbol%3BAcc:HGNC:16447]
ENSG00000124333	33.65	37.30	28.73	31.87	35.33	33.67	-0.0115453865511044	4.82999814217871	0.941257650100031	0.996064041832199	X:155881292-155943769:+	VAMP7	62;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006897,biological_process endocytosis;GO:0006906,biological_process vesicle fusion;GO:0006911,biological_process phagocytosis, engulfment;GO:0008021,cellular_component synaptic vesicle;GO:0008333,biological_process endosome to lysosome transport;GO:0009986,cellular_component cell surface;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030133,cellular_component transport vesicle;GO:0030141,cellular_component secretory granule;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0030658,cellular_component transport vesicle membrane;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030667,cellular_component secretory granule membrane;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031091,cellular_component platelet alpha granule;GO:0031143,cellular_component pseudopodium;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031902,cellular_component late endosome membrane;GO:0034197,biological_process triglyceride transport;GO:0035493,biological_process SNARE complex assembly;GO:0035577,cellular_component azurophil granule membrane;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0043005,cellular_component neuron projection;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043308,biological_process eosinophil degranulation;GO:0043312,biological_process neutrophil degranulation;GO:0043320,biological_process natural killer cell degranulation;GO:0045177,cellular_component apical part of cell;GO:0045202,cellular_component synapse;GO:0045335,cellular_component phagocytic vesicle;GO:0047496,biological_process vesicle transport along microtubule;GO:0048280,biological_process vesicle fusion with Golgi apparatus;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050775,biological_process positive regulation of dendrite morphogenesis;GO:0061024,biological_process membrane organization;GO:0070062,cellular_component extracellular exosome;GO:1900483,biological_process regulation of protein targeting to vacuolar membrane;GO:1903595,biological_process positive regulation of histamine secretion by mast cell	VAMP7; vesicle-associated membrane protein 7; K08515	vesicle associated membrane protein 7 [Source:HGNC Symbol%3BAcc:HGNC:11486]
ENSG00000218336	18.81	19.51	16.97	17.49	20.07	18.38	-0.00615352673326024	7.2465602283201	0.941448980046507	0.996181586336824	4:182143986-182803024:+	TENM3	19;GO:0000902,biological_process cell morphogenesis;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157,biological_process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165,biological_process signal transduction;GO:0010976,biological_process positive regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030424,cellular_component axon;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0046982,molecular_function protein heterodimerization activity;GO:0048593,biological_process camera-type eye morphogenesis;GO:0048666,biological_process neuron development;GO:0050839,molecular_function cell adhesion molecule binding;GO:0097264,biological_process self proteolysis	NA	teneurin transmembrane protein 3 [Source:HGNC Symbol%3BAcc:HGNC:29944]
ENSG00000221843	0.28	0.27	0.42	0.35	0.31	0.30	0.0272556368684778	2.43098116272785	0.941795640392588	0.996418091797856	2:27537385-27582721:+	C2orf16	2;GO:0005634,cellular_component nucleus;GO:0070062,cellular_component extracellular exosome	NA	chromosome 2 open reading frame 16 [Source:HGNC Symbol%3BAcc:HGNC:25275]
ENSG00000076351	4.42	5.27	4.71	4.48	5.31	4.83	-0.0199218355327084	2.87106973128251	0.94190273481601	0.996418091797856	17:28394755-28407197:-	SLC46A1	23;GO:0005215,molecular_function transporter activity;GO:0005542,molecular_function folic acid binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008517,molecular_function folic acid transporter activity;GO:0009986,cellular_component cell surface;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015232,molecular_function heme transporter activity;GO:0015350,molecular_function methotrexate transporter activity;GO:0015884,biological_process folic acid transport;GO:0015886,biological_process heme transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0031526,cellular_component brush border membrane;GO:0046655,biological_process folic acid metabolic process;GO:0051958,biological_process methotrexate transport;GO:0055085,biological_process transmembrane transport;GO:0098829,biological_process intestinal folate absorption;GO:1902600,biological_process hydrogen ion transmembrane transport;GO:1904447,biological_process folic acid import into cell	SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1; K14613	solute carrier family 46 member 1 [Source:HGNC Symbol%3BAcc:HGNC:30521]
ENSG00000100142	34.06	33.30	27.40	31.53	32.95	31.48	-0.00834974197455029	5.1698595745227	0.941913307754455	0.996418091797856	22:37952606-38041915:+	POLR2F	31;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001054,molecular_function RNA polymerase I activity;GO:0001055,molecular_function RNA polymerase II activity;GO:0001056,molecular_function RNA polymerase III activity;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0032481,biological_process positive regulation of type I interferon production;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2; K03014	RNA polymerase II subunit F [Source:HGNC Symbol%3BAcc:HGNC:9193]
ENSG00000099814	13.31	12.80	13.03	12.35	14.21	12.76	0.00635341405317103	5.96797391879476	0.942165825737149	0.996600289294864	14:104865279-104896770:+	CEP170B	3;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule	NA	centrosomal protein 170B [Source:HGNC Symbol%3BAcc:HGNC:20362]
ENSG00000155304	39.59	42.61	42.45	43.08	39.02	43.00	0.00450605146866029	5.88226962876395	0.942458148021709	0.996824556185538	21:14371114-14383484:-	HSPA13	6;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0070062,cellular_component extracellular exosome	NA	heat shock protein family A (Hsp70) member 13 [Source:HGNC Symbol%3BAcc:HGNC:11375]
ENSG00000071243	8.85	7.91	9.51	7.82	8.39	10.55	-0.0113555104622837	3.54001479158503	0.942550956443307	0.996837779869709	7:120950748-120977216:+	ING3	16;GO:0000812,cellular_component Swr1 complex;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016569,biological_process covalent chromatin modification;GO:0032777,cellular_component Piccolo NuA4 histone acetyltransferase complex;GO:0035064,molecular_function methylated histone binding;GO:0035267,cellular_component NuA4 histone acetyltransferase complex;GO:0040008,biological_process regulation of growth;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043967,biological_process histone H4 acetylation;GO:0043968,biological_process histone H2A acetylation;GO:0046872,molecular_function metal ion binding	NA	inhibitor of growth family member 3 [Source:HGNC Symbol%3BAcc:HGNC:14587]
ENSG00000174837	0.77	0.69	0.61	0.81	0.44	0.77	0.0475040955325802	1.02786640167075	0.942740305169463	0.99685308609142	19:6887565-6940459:+	ADGRE1	16;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0004871,molecular_function signal transducer activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005509,molecular_function calcium ion binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0009897,cellular_component external side of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0071944,cellular_component cell periphery	NA	adhesion G protein-coupled receptor E1 [Source:HGNC Symbol%3BAcc:HGNC:3336]
ENSG00000117834	0.84	0.96	0.97	0.96	1.11	0.80	-0.0376337356686625	1.14064586711601	0.942751329243333	0.99685308609142	1:48222684-48248644:+	SLC5A9	14;GO:0005215,molecular_function transporter activity;GO:0005362,molecular_function low-affinity glucose:sodium symporter activity;GO:0005412,molecular_function glucose:sodium symporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006814,biological_process sodium ion transport;GO:0008645,biological_process hexose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:1904659,biological_process glucose transmembrane transport	NA	solute carrier family 5 member 9 [Source:HGNC Symbol%3BAcc:HGNC:22146]
ENSG00000225830	2.05	2.08	1.94	1.95	2.32	1.80	0.0112638429778111	3.71962320096294	0.942836291230229	0.99685308609142	10:49455367-49539538:-	ERCC6	43;GO:0000166,molecular_function nucleotide binding;GO:0000303,biological_process response to superoxide;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006284,biological_process base-excision repair;GO:0006290,biological_process pyrimidine dimer repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007256,biological_process activation of JNKK activity;GO:0007257,biological_process activation of JUN kinase activity;GO:0008022,molecular_function protein C-terminus binding;GO:0008023,cellular_component transcription elongation factor complex;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009411,biological_process response to UV;GO:0009636,biological_process response to toxic substance;GO:0010165,biological_process response to X-ray;GO:0010224,biological_process response to UV-B;GO:0010332,biological_process response to gamma radiation;GO:0016787,molecular_function hydrolase activity;GO:0030296,molecular_function protein tyrosine kinase activator activity;GO:0032403,molecular_function protein complex binding;GO:0032784,biological_process regulation of DNA-templated transcription, elongation;GO:0032786,biological_process positive regulation of DNA-templated transcription, elongation;GO:0035264,biological_process multicellular organism growth;GO:0045494,biological_process photoreceptor cell maintenance;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0047485,molecular_function protein N-terminus binding;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity	ERCC6, CSB, RAD26; DNA excision repair protein ERCC-6; K10841	ERCC excision repair 6%2C chromatin remodeling factor [Source:HGNC Symbol%3BAcc:HGNC:3438]
ENSG00000121940	22.30	25.77	24.35	22.63	25.10	25.52	-0.0088745010129024	5.43780033522087	0.942956118522367	0.99685308609142	1:108929507-108963457:-	CLCC1	12;GO:0005254,molecular_function chloride channel activity;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034707,cellular_component chloride channel complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:1902476,biological_process chloride transmembrane transport	NA	chloride channel CLIC like 1 [Source:HGNC Symbol%3BAcc:HGNC:29675]
ENSG00000106683	48.01	46.62	50.38	50.20	45.80	50.76	-0.00489112239123152	6.70218939682326	0.943007189244985	0.99685308609142	7:74082932-74122525:+	LIMK1	30;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0007399,biological_process nervous system development;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0031072,molecular_function heat shock protein binding;GO:0032233,biological_process positive regulation of actin filament bundle assembly;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043005,cellular_component neuron projection;GO:0045773,biological_process positive regulation of axon extension;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051444,biological_process negative regulation of ubiquitin-protein transferase activity;GO:0051496,biological_process positive regulation of stress fiber assembly	LIMK1; LIM domain kinase 1 [EC:2.7.11.1]; K05743	LIM domain kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:6613]
ENSG00000187605	2.12	1.64	2.41	1.88	2.12	2.18	0.0197485446980697	3.50598917058936	0.94316543330302	0.99685308609142	2:73986403-74108176:+	TET3	18;GO:0001940,cellular_component male pronucleus;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006493,biological_process protein O-linked glycosylation;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0044727,biological_process DNA demethylation of male pronucleus;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070579,molecular_function methylcytosine dioxygenase activity;GO:0080111,biological_process DNA demethylation;GO:0080182,biological_process histone H3-K4 trimethylation	NA	tet methylcytosine dioxygenase 3 [Source:HGNC Symbol%3BAcc:HGNC:28313]
ENSG00000112541	20.57	21.55	21.09	20.64	20.78	22.50	-0.00639550680515015	5.97145973664957	0.943176074886093	0.99685308609142	6:165327286-165986603:-	PDE10A	24;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0004112,molecular_function cyclic-nucleotide phosphodiesterase activity;GO:0004114,molecular_function 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115,molecular_function 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118,molecular_function cGMP-stimulated cyclic-nucleotide phosphodiesterase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006198,biological_process cAMP catabolic process;GO:0007165,biological_process signal transduction;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0008144,molecular_function drug binding;GO:0008152,biological_process metabolic process;GO:0010738,biological_process regulation of protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0030552,molecular_function cAMP binding;GO:0030553,molecular_function cGMP binding;GO:0043025,cellular_component neuronal cell body;GO:0043204,cellular_component perikaryon;GO:0043949,biological_process regulation of cAMP-mediated signaling;GO:0046069,biological_process cGMP catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047555,molecular_function 3',5'-cyclic-GMP phosphodiesterase activity	cpdP; 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]; K01120	phosphodiesterase 10A [Source:HGNC Symbol%3BAcc:HGNC:8772]
ENSG00000277758	0.68	1.26	1.06	1.43	0.72	0.92	-0.0585816116107547	0.868239214391312	0.943286569104695	0.99685308609142	10:47750863-47763592:-	FO681492.1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	NA
ENSG00000101639	10.45	10.03	9.88	9.60	10.61	10.52	-0.00506372928588288	6.29795733930886	0.943288193767004	0.99685308609142	18:12991361-13125052:+	CEP192	14;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000242,cellular_component pericentriolar material;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0019902,molecular_function phosphatase binding;GO:0051225,biological_process spindle assembly;GO:0051298,biological_process centrosome duplication;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 192 [Source:HGNC Symbol%3BAcc:HGNC:25515]
ENSG00000272886	7.96	7.05	8.88	8.01	7.77	8.57	-0.00747905506362822	3.83428858020836	0.943402545649279	0.996889060964033	3:53283427-53347610:-	DCP1A	19;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008047,molecular_function enzyme activator activity;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019894,molecular_function kinesin binding;GO:0030234,molecular_function enzyme regulator activity;GO:0031087,biological_process deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0042802,molecular_function identical protein binding;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:1903608,biological_process protein localization to cytoplasmic stress granule	DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]; K12610	decapping mRNA 1A [Source:HGNC Symbol%3BAcc:HGNC:18714]
ENSG00000170852	31.14	30.07	30.05	31.25	28.93	31.49	0.0053702997468924	5.83750948117039	0.943751346580312	0.997100601801826	7:32868171-32894131:-	KBTBD2	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch repeat and BTB domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:21751]
ENSG00000185187	1.68	0.80	0.80	1.20	0.97	1.08	0.0484903589410563	0.905446322247385	0.94376339084586	0.997100601801826	11:405715-417455:-	SIGIRR	9;GO:0001960,biological_process negative regulation of cytokine-mediated signaling pathway;GO:0005515,molecular_function protein binding;GO:0006953,biological_process acute-phase response;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031665,biological_process negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0043433,biological_process negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045079,biological_process negative regulation of chemokine biosynthetic process	NA	single Ig and TIR domain containing [Source:HGNC Symbol%3BAcc:HGNC:30575]
ENSG00000135083	5.61	5.36	5.50	5.15	5.97	5.35	0.0151706343089039	3.0678420833091	0.943937870679427	0.997104032670664	5:160251651-160345396:-	CCNJL	2;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus	NA	cyclin J like [Source:HGNC Symbol%3BAcc:HGNC:25876]
ENSG00000181929	68.53	71.24	66.22	70.82	74.39	63.21	-0.00587785526761512	6.31068530923824	0.944209741377244	0.997104032670664	12:49002273-49019197:-	PRKAG1	32;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004679,molecular_function AMP-activated protein kinase activity;GO:0004691,molecular_function cAMP-dependent protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006468,biological_process protein phosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0008603,molecular_function cAMP-dependent protein kinase regulator activity;GO:0010628,biological_process positive regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016208,molecular_function AMP binding;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0043531,molecular_function ADP binding;GO:0045860,biological_process positive regulation of protein kinase activity;GO:0070062,cellular_component extracellular exosome;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1902593,biological_process single-organism nuclear import	PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit; K07200	protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:9385]
ENSG00000184635	3.86	3.89	3.65	4.12	3.69	3.55	0.0155200132797933	3.05983443293363	0.944260688607413	0.997104032670664	19:19900912-19963464:+	ZNF93	11;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0070895,biological_process negative regulation of transposon integration	NA	zinc finger protein 93 [Source:HGNC Symbol%3BAcc:HGNC:13169]
ENSG00000151332	34.92	33.27	37.14	34.04	37.64	34.18	0.00813032351103903	5.25611456761079	0.944270820545295	0.997104032670664	14:36298557-36320676:-	MBIP	12;GO:0000173,biological_process inactivation of MAPK activity involved in osmosensory signaling pathway;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005671,cellular_component Ada2/Gcn5/Ada3 transcription activator complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0030366,molecular_function molybdopterin synthase activity;GO:0032324,biological_process molybdopterin cofactor biosynthetic process;GO:0042802,molecular_function identical protein binding;GO:0043966,biological_process histone H3 acetylation	NA	MAP3K12 binding inhibitory protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20427]
ENSG00000103343	4.48	5.18	5.39	5.33	5.55	4.46	-0.0171572980832664	2.87342098823714	0.94445746821229	0.997104032670664	16:3401234-3409370:+	ZNF174	18;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0015629,cellular_component actin cytoskeleton;GO:0042803,molecular_function protein homodimerization activity;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 174 [Source:HGNC Symbol%3BAcc:HGNC:12963]
ENSG00000165417	14.15	13.12	14.12	15.00	13.19	13.85	-0.00648818862971528	4.04380312124864	0.944462808493605	0.997104032670664	14:81175451-81221377:-	GTF2A1	19;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005672,cellular_component transcription factor TFIIA complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0017025,molecular_function TBP-class protein binding;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0046982,molecular_function protein heterodimerization activity	TFIIA1, GTF2A1, TOA1; transcription initiation factor TFIIA large subunit; K03122	general transcription factor IIA subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:4646]
ENSG00000042286	13.06	9.91	11.44	12.58	10.57	11.94	-0.00631162271273463	3.72062989245623	0.944791239474771	0.997104032670664	10:70098222-70132934:-	AIFM2	17;GO:0003677,molecular_function DNA binding;GO:0004174,molecular_function electron-transferring-flavoprotein dehydrogenase activity;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	NA	apoptosis inducing factor%2C mitochondria associated 2 [Source:HGNC Symbol%3BAcc:HGNC:21411]
ENSG00000100441	18.13	18.14	15.81	16.31	17.26	18.63	0.00508018078578606	5.15000827371906	0.944848173091682	0.997104032670664	14:24429285-24441834:+	KHNYN	4;GO:0003674,molecular_function molecular_function;GO:0003723,molecular_function RNA binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	KH and NYN domain containing [Source:HGNC Symbol%3BAcc:HGNC:20166]
ENSG00000183513	106.76	104.08	113.25	92.57	112.88	119.65	0.00814378865264949	4.81317218809144	0.944922448972053	0.997104032670664	2:98599309-98608515:-	COA5	3;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0033617,biological_process mitochondrial respiratory chain complex IV assembly	NA	cytochrome c oxidase assembly factor 5 [Source:HGNC Symbol%3BAcc:HGNC:33848]
ENSG00000135829	55.04	64.26	52.99	55.99	61.75	56.59	-0.00626375383855966	7.78315202716158	0.944988548293992	0.997104032670664	1:182839368-182887751:+	DHX9	73;GO:0000166,molecular_function nucleotide binding;GO:0000380,biological_process alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001069,molecular_function regulatory region RNA binding;GO:0001085,molecular_function RNA polymerase II transcription factor binding;GO:0001649,biological_process osteoblast differentiation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003688,molecular_function DNA replication origin binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003723,molecular_function RNA binding;GO:0003724,molecular_function RNA helicase activity;GO:0003725,molecular_function double-stranded RNA binding;GO:0003727,molecular_function single-stranded RNA binding;GO:0003729,molecular_function mRNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004004,molecular_function ATP-dependent RNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005726,cellular_component perichromatin fibrils;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0006396,biological_process RNA processing;GO:0010501,biological_process RNA secondary structure unwinding;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031490,molecular_function chromatin DNA binding;GO:0032481,biological_process positive regulation of type I interferon production;GO:0032508,biological_process DNA duplex unwinding;GO:0033681,molecular_function ATP-dependent 3'-5' DNA/RNA helicase activity;GO:0034459,molecular_function ATP-dependent 3'-5' RNA helicase activity;GO:0035068,cellular_component micro-ribonucleoprotein complex;GO:0035197,molecular_function siRNA binding;GO:0035549,biological_process positive regulation of interferon-beta secretion;GO:0035613,molecular_function RNA stem-loop binding;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0039695,biological_process DNA-templated viral transcription;GO:0042788,cellular_component polysomal ribosome;GO:0043140,molecular_function ATP-dependent 3'-5' DNA helicase activity;GO:0045142,molecular_function triplex DNA binding;GO:0045739,biological_process positive regulation of DNA repair;GO:0045740,biological_process positive regulation of DNA replication;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047429,molecular_function nucleoside-triphosphate diphosphatase activity;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048511,biological_process rhythmic process;GO:0050434,biological_process positive regulation of viral transcription;GO:0050684,biological_process regulation of mRNA processing;GO:0060760,biological_process positive regulation of response to cytokine stimulus;GO:0061676,molecular_function importin-alpha family protein binding;GO:0070934,biological_process CRD-mediated mRNA stabilization;GO:0070937,cellular_component CRD-mediated mRNA stability complex;GO:0071360,biological_process cellular response to exogenous dsRNA;GO:0097165,cellular_component nuclear stress granule;GO:1902741,biological_process positive regulation of interferon-alpha secretion;GO:1903608,biological_process protein localization to cytoplasmic stress granule;GO:1904469,biological_process positive regulation of tumor necrosis factor secretion;GO:1904973,biological_process positive regulation of viral translation;GO:1905538,molecular_function polysome binding;GO:1990518,molecular_function single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity;GO:1990841,molecular_function promoter-specific chromatin binding;GO:2000765,biological_process regulation of cytoplasmic translation;GO:2000767,biological_process positive regulation of cytoplasmic translation;GO:2000778,biological_process positive regulation of interleukin-6 secretion	NA	DExH-box helicase 9 [Source:HGNC Symbol%3BAcc:HGNC:2750]
ENSG00000125875	62.45	60.07	65.02	66.39	61.04	62.41	-0.00424704861160793	6.25310927482225	0.945035272579059	0.997104032670664	20:435479-462553:-	TBC1D20	29;GO:0001675,biological_process acrosome assembly;GO:0002088,biological_process lens development in camera-type eye;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007030,biological_process Golgi organization;GO:0007283,biological_process spermatogenesis;GO:0008584,biological_process male gonad development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0017137,molecular_function Rab GTPase binding;GO:0019068,biological_process virion assembly;GO:0030173,cellular_component integral component of Golgi membrane;GO:0031965,cellular_component nuclear membrane;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034389,biological_process lipid particle organization;GO:0043010,biological_process camera-type eye development;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044829,biological_process positive regulation by host of viral genome replication;GO:0046726,biological_process positive regulation by virus of viral protein levels in host cell;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization;GO:0070309,biological_process lens fiber cell morphogenesis;GO:0072520,biological_process seminiferous tubule development;GO:0090110,biological_process cargo loading into COPII-coated vesicle;GO:1902953,biological_process positive regulation of ER to Golgi vesicle-mediated transport	NA	TBC1 domain family member 20 [Source:HGNC Symbol%3BAcc:HGNC:16133]
ENSG00000157833	0.80	1.01	0.75	0.91	0.86	0.77	0.00930686841547583	1.2528111092006	0.945065463430931	0.997104032670664	2:26173090-26189663:+	GAREM2	1;GO:0070062,cellular_component extracellular exosome	NA	GRB2 associated regulator of MAPK1 subtype 2 [Source:HGNC Symbol%3BAcc:HGNC:27172]
ENSG00000104714	9.32	7.98	8.58	9.74	7.87	8.76	-0.00934882642326101	3.84644961923204	0.945070437078055	0.997104032670664	8:614745-738106:-	ERICH1	NA	NA	glutamate rich 1 [Source:HGNC Symbol%3BAcc:HGNC:27234]
ENSG00000126012	26.41	26.52	28.35	27.19	26.25	28.79	-0.00475559295999628	7.0674056051862	0.945111094217497	0.997104032670664	X:53191320-53225422:-	KDM5C	19;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0009636,biological_process response to toxic substance;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0032452,molecular_function histone demethylase activity;GO:0032453,molecular_function histone demethylase activity (H3-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process	NA	lysine demethylase 5C [Source:HGNC Symbol%3BAcc:HGNC:11114]
ENSG00000136811	25.73	26.94	24.86	25.33	27.31	25.20	0.00436575178035971	6.30345150593615	0.945130145861745	0.997104032670664	9:128455185-128501292:+	ODF2	22;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0001520,cellular_component outer dense fiber;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0030154,biological_process cell differentiation;GO:0042995,cellular_component cell projection;GO:0097539,cellular_component ciliary transition fiber;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	outer dense fiber of sperm tails 2 [Source:HGNC Symbol%3BAcc:HGNC:8114]
ENSG00000147548	7.63	7.38	8.02	7.83	7.75	7.76	-0.00474082571108195	5.10081846982438	0.945148993434152	0.997104032670664	8:38269696-38382272:-	NSD3	14;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008168,molecular_function methyltransferase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016571,biological_process histone methylation;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0046872,molecular_function metal ion binding	WHSC1L1, NSD3; [histone H3]-lysine36 N-dimethyltransferase NSD3 [EC:2.1.1.357]; K11425	nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol%3BAcc:HGNC:12767]
ENSG00000143398	27.84	26.25	29.41	29.23	26.83	27.87	0.00698885159972385	5.70168695921289	0.945185590753568	0.997104032670664	1:151197948-151249536:+	PIP5K1A	43;GO:0000166,molecular_function nucleotide binding;GO:0000285,molecular_function 1-phosphatidylinositol-3-phosphate 5-kinase activity;GO:0001726,cellular_component ruffle;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005847,cellular_component mRNA cleavage and polyadenylation specificity factor complex;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006909,biological_process phagocytosis;GO:0007165,biological_process signal transduction;GO:0008654,biological_process phospholipid biosynthetic process;GO:0010761,biological_process fibroblast migration;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016307,molecular_function phosphatidylinositol phosphate kinase activity;GO:0016308,molecular_function 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0019900,molecular_function kinase binding;GO:0030027,cellular_component lamellipodium;GO:0030216,biological_process keratinocyte differentiation;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0032587,cellular_component ruffle membrane;GO:0042995,cellular_component cell projection;GO:0046488,biological_process phosphatidylinositol metabolic process;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0048041,biological_process focal adhesion assembly;GO:0052810,molecular_function 1-phosphatidylinositol-5-kinase activity;GO:0052811,molecular_function 1-phosphatidylinositol-3-phosphate 4-kinase activity;GO:0052812,molecular_function phosphatidylinositol-3,4-bisphosphate 5-kinase activity;GO:0060326,biological_process cell chemotaxis;GO:0072661,biological_process protein targeting to plasma membrane;GO:0090630,biological_process activation of GTPase activity;GO:0097178,biological_process ruffle assembly	PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]; K00889	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [Source:HGNC Symbol%3BAcc:HGNC:8994]
ENSG00000067560	709.80	738.44	666.41	679.58	751.98	693.39	0.00451171368312179	8.98807221031884	0.945269369768004	0.997104032670664	3:49359144-49412998:-	RHOA	77;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0007049,biological_process cell cycle;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016477,biological_process cell migration;GO:0016579,biological_process protein deubiquitination;GO:0017022,molecular_function myosin binding;GO:0021762,biological_process substantia nigra development;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0030054,cellular_component cell junction;GO:0030168,biological_process platelet activation;GO:0030334,biological_process regulation of cell migration;GO:0030496,cellular_component midbody;GO:0030667,cellular_component secretory granule membrane;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031982,cellular_component vesicle;GO:0032154,cellular_component cleavage furrow;GO:0032467,biological_process positive regulation of cytokinesis;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0033688,biological_process regulation of osteoblast proliferation;GO:0035385,biological_process Roundabout signaling pathway;GO:0036089,biological_process cleavage furrow formation;GO:0038027,biological_process apolipoprotein A-I-mediated signaling pathway;GO:0042346,biological_process positive regulation of NF-kappaB import into nucleus;GO:0042995,cellular_component cell projection;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043149,biological_process stress fiber assembly;GO:0043197,cellular_component dendritic spine;GO:0043296,cellular_component apical junction complex;GO:0043297,biological_process apical junction assembly;GO:0043312,biological_process neutrophil degranulation;GO:0043542,biological_process endothelial cell migration;GO:0043931,biological_process ossification involved in bone maturation;GO:0044319,biological_process wound healing, spreading of cells;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045792,biological_process negative regulation of cell size;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050771,biological_process negative regulation of axonogenesis;GO:0050772,biological_process positive regulation of axonogenesis;GO:0050919,biological_process negative chemotaxis;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051301,biological_process cell division;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0060193,biological_process positive regulation of lipase activity;GO:0061383,biological_process trabecula morphogenesis;GO:0070062,cellular_component extracellular exosome;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:0071944,cellular_component cell periphery;GO:0090051,biological_process negative regulation of cell migration involved in sprouting angiogenesis;GO:0090307,biological_process mitotic spindle assembly;GO:0097498,biological_process endothelial tube lumen extension;GO:0101003,cellular_component ficolin-1-rich granule membrane;GO:1902766,biological_process skeletal muscle satellite cell migration;GO:1903673,biological_process mitotic cleavage furrow formation;GO:1990869,biological_process cellular response to chemokine;GO:2000145,biological_process regulation of cell motility;GO:2000406,biological_process positive regulation of T cell migration	NA	ras homolog family member A [Source:HGNC Symbol%3BAcc:HGNC:667]
ENSG00000164051	12.72	12.71	11.40	13.48	11.19	12.15	0.00934988309487937	3.93391158858701	0.945303589869923	0.997104032670664	3:48432163-48440456:-	CCDC51	3;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	coiled-coil domain containing 51 [Source:HGNC Symbol%3BAcc:HGNC:25714]
ENSG00000260643	3.53	3.73	1.96	3.63	2.73	2.64	0.0331841661474482	1.05561374256015	0.945373186216148	0.997104032670664	16:81053586-81096296:-	AC092718.3	5;GO:0005739,cellular_component mitochondrion;GO:0005960,cellular_component glycine cleavage complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019464,biological_process glycine decarboxylation via glycine cleavage system	gcvH, GCSH; glycine cleavage system H protein; K02437	NA
ENSG00000147614	2.02	0.64	1.19	0.93	0.79	2.08	0.056362201881736	0.613839329098217	0.945529853778264	0.997174225103119	8:85987322-86154228:+	ATP6V0D2	25;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007034,biological_process vacuolar transport;GO:0007035,biological_process vacuolar acidification;GO:0008286,biological_process insulin receptor signaling pathway;GO:0008553,molecular_function hydrogen-exporting ATPase activity, phosphorylative mechanism;GO:0010008,cellular_component endosome membrane;GO:0015078,molecular_function hydrogen ion transmembrane transporter activity;GO:0015991,biological_process ATP hydrolysis coupled proton transport;GO:0015992,biological_process proton transport;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0016324,cellular_component apical plasma membrane;GO:0016471,cellular_component vacuolar proton-transporting V-type ATPase complex;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0033179,cellular_component proton-transporting V-type ATPase, V0 domain;GO:0033572,biological_process transferrin transport;GO:0034220,biological_process ion transmembrane transport;GO:0046961,molecular_function proton-transporting ATPase activity, rotational mechanism;GO:0070062,cellular_component extracellular exosome;GO:0090383,biological_process phagosome acidification	ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d; K02146	ATPase H+ transporting V0 subunit d2 [Source:HGNC Symbol%3BAcc:HGNC:18266]
ENSG00000111666	31.44	27.11	30.75	31.11	30.67	28.02	0.00936354989275204	5.34098459554936	0.945834728719817	0.997174225103119	12:101696946-101744140:+	CHPT1	16;GO:0000139,cellular_component Golgi membrane;GO:0001558,biological_process regulation of cell growth;GO:0004142,molecular_function diacylglycerol cholinephosphotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0006629,biological_process lipid metabolic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006657,biological_process CDP-choline pathway;GO:0006663,biological_process platelet activating factor biosynthetic process;GO:0008654,biological_process phospholipid biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016780,molecular_function phosphotransferase activity, for other substituted phosphate groups;GO:0019992,molecular_function diacylglycerol binding;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	CHPT1, CPT1; diacylglycerol cholinephosphotransferase [EC:2.7.8.2]; K00994	choline phosphotransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:17852]
ENSG00000165476	36.54	33.52	37.35	36.69	31.51	39.62	0.00845149951180332	4.86108898253999	0.945849017051164	0.997174225103119	10:63521362-63625123:+	REEP3	9;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005874,cellular_component microtubule;GO:0006998,biological_process nuclear envelope organization;GO:0007049,biological_process cell cycle;GO:0007084,biological_process mitotic nuclear envelope reassembly;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0051301,biological_process cell division	NA	receptor accessory protein 3 [Source:HGNC Symbol%3BAcc:HGNC:23711]
ENSG00000085871	31.55	37.27	30.04	33.96	34.22	30.46	0.00624533559568228	3.86928691981542	0.946005444763155	0.997174225103119	4:139665767-139740745:+	MGST2	24;GO:0004364,molecular_function glutathione transferase activity;GO:0004464,molecular_function leukotriene-C4 synthase activity;GO:0004602,molecular_function glutathione peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006691,biological_process leukotriene metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0006805,biological_process xenobiotic metabolic process;GO:0008047,molecular_function enzyme activator activity;GO:0010243,biological_process response to organonitrogen compound;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0019370,biological_process leukotriene biosynthetic process;GO:0031090,cellular_component organelle membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0043085,biological_process positive regulation of catalytic activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0098869,biological_process cellular oxidant detoxification;GO:1901687,biological_process glutathione derivative biosynthetic process	GST, gst; glutathione S-transferase [EC:2.5.1.18]; K00799	microsomal glutathione S-transferase 2 [Source:HGNC Symbol%3BAcc:HGNC:7063]
ENSG00000160563	19.05	23.33	16.76	19.27	20.22	19.47	0.00551845617994051	4.26791605578542	0.946117024919033	0.997174225103119	9:131860106-132079908:-	MED27	16;GO:0000151,cellular_component ubiquitin ligase complex;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016567,biological_process protein ubiquitination;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0061630,molecular_function ubiquitin protein ligase activity	MED27; mediator of RNA polymerase II transcription subunit 27; K15170	mediator complex subunit 27 [Source:HGNC Symbol%3BAcc:HGNC:2377]
ENSG00000127241	0.63	0.73	0.87	0.79	0.73	0.70	0.0259641160744184	1.30478896412005	0.946126401085975	0.997174225103119	3:187217284-187292022:-	MASP1	19;GO:0001867,biological_process complement activation, lectin pathway;GO:0002376,biological_process immune system process;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006898,biological_process receptor-mediated endocytosis;GO:0006956,biological_process complement activation;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0042803,molecular_function protein homodimerization activity;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0048306,molecular_function calcium-dependent protein binding	MASP1; mannan-binding lectin serine protease 1 [EC:3.4.21.-]; K03992	mannan binding lectin serine peptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:6901]
ENSG00000158423	1.27	1.55	2.20	1.15	1.75	1.98	0.0498556696313211	1.06329241588613	0.946149504020105	0.997174225103119	X:53422689-53431120:+	RIBC1	1;GO:0005515,molecular_function protein binding	NA	RIB43A domain with coiled-coils 1 [Source:HGNC Symbol%3BAcc:HGNC:26537]
ENSG00000149639	4.86	4.82	4.88	4.99	5.13	4.63	-0.00612363187421394	4.63139035629166	0.946287103123465	0.997174225103119	20:36777441-36863686:-	SOGA1	7;GO:0003674,molecular_function molecular_function;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0008286,biological_process insulin receptor signaling pathway;GO:0010506,biological_process regulation of autophagy;GO:0045721,biological_process negative regulation of gluconeogenesis;GO:0070062,cellular_component extracellular exosome	NA	suppressor of glucose%2C autophagy associated 1 [Source:HGNC Symbol%3BAcc:HGNC:16111]
ENSG00000145536	1.55	1.95	1.96	1.83	1.50	2.10	0.0080556531332184	2.77183280291842	0.946317437337416	0.997174225103119	5:5140329-5320304:+	ADAMTS16	12;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0003073,biological_process regulation of systemic arterial blood pressure;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:1902017,biological_process regulation of cilium assembly	NA	ADAM metallopeptidase with thrombospondin type 1 motif 16 [Source:HGNC Symbol%3BAcc:HGNC:17108]
ENSG00000140548	4.04	3.43	3.24	3.47	3.92	3.54	-0.0124186143995863	3.02072831581823	0.946332490996426	0.997174225103119	15:90001391-90082206:+	ZNF710	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 710 [Source:HGNC Symbol%3BAcc:HGNC:25352]
ENSG00000149289	5.31	5.15	6.00	5.69	6.04	5.00	-0.0054060830128695	3.90285924239995	0.946363772143906	0.997174225103119	11:110093360-110171841:+	ZC3H12C	8;GO:0003674,molecular_function molecular_function;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	zinc finger CCCH-type containing 12C [Source:HGNC Symbol%3BAcc:HGNC:29362]
ENSG00000136830	118.53	113.42	116.31	119.75	115.61	116.77	-0.0038536545434191	8.04146637426928	0.946403733661472	0.997174225103119	9:127505338-127578989:-	FAM129B	26;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0007411,biological_process axon guidance;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016525,biological_process negative regulation of angiogenesis;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030948,biological_process negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032274,biological_process gonadotropin secretion;GO:0034337,biological_process RNA folding;GO:0040019,biological_process positive regulation of embryonic development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044029,biological_process hypomethylation of CpG island;GO:0045296,molecular_function cadherin binding;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0048743,biological_process positive regulation of skeletal muscle fiber development;GO:0070062,cellular_component extracellular exosome;GO:2000279,biological_process negative regulation of DNA biosynthetic process	NA	family with sequence similarity 129 member B [Source:HGNC Symbol%3BAcc:HGNC:25282]
ENSG00000277161	8.59	7.77	6.18	8.37	6.47	8.09	-0.0143775972707667	3.53910209874727	0.946633936642164	0.997332121502222	17:36535019-36539310:+	PIGW	11;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006505,biological_process GPI anchor metabolic process;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0072659,biological_process protein localization to plasma membrane	PIGW; glucosaminylphosphatidylinositol acyltransferase [EC:2.3.-.-]; K05283	phosphatidylinositol glycan anchor biosynthesis class W [Source:HGNC Symbol%3BAcc:HGNC:23213]
ENSG00000146205	0.73	0.89	0.61	0.79	0.85	0.63	-0.0388932610455883	1.26056894922413	0.946820190017452	0.997362467475334	2:241188508-241225377:+	ANO7	21;GO:0005229,molecular_function intracellular calcium activated chloride channel activity;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006821,biological_process chloride transport;GO:0006869,biological_process lipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017128,molecular_function phospholipid scramblase activity;GO:0030054,cellular_component cell junction;GO:0034220,biological_process ion transmembrane transport;GO:0046983,molecular_function protein dimerization activity;GO:0061588,biological_process calcium activated phospholipid scrambling;GO:0061589,biological_process calcium activated phosphatidylserine scrambling;GO:0061590,biological_process calcium activated phosphatidylcholine scrambling;GO:0061591,biological_process calcium activated galactosylceramide scrambling;GO:1902476,biological_process chloride transmembrane transport	NA	anoctamin 7 [Source:HGNC Symbol%3BAcc:HGNC:31677]
ENSG00000154447	5.97	5.17	5.22	6.27	5.21	5.17	-0.00898288669995096	3.89102547590031	0.947248678226893	0.997362467475334	4:169094255-169271105:-	SH3RF1	15;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030027,cellular_component lamellipodium;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046328,biological_process regulation of JNK cascade;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	NA	SH3 domain containing ring finger 1 [Source:HGNC Symbol%3BAcc:HGNC:17650]
ENSG00000105204	1.21	1.24	1.11	0.89	1.38	1.39	-0.0351731931679982	1.30450023657758	0.947549458274477	0.997362467475334	19:39825349-39834201:-	DYRK1B	17;GO:0000166,molecular_function nucleotide binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006468,biological_process protein phosphorylation;GO:0007520,biological_process myoblast fusion;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0060612,biological_process adipose tissue development	NA	dual specificity tyrosine phosphorylation regulated kinase 1B [Source:HGNC Symbol%3BAcc:HGNC:3092]
ENSG00000178896	15.14	11.86	12.83	12.90	15.25	11.83	0.0162251719163074	3.71817527415896	0.947565401195154	0.997362467475334	8:144078625-144080647:+	EXOSC4	30;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000177,cellular_component cytoplasmic exosome (RNase complex);GO:0000178,cellular_component exosome (RNase complex);GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000956,biological_process nuclear-transcribed mRNA catabolic process;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006364,biological_process rRNA processing;GO:0016075,biological_process rRNA catabolic process;GO:0017091,molecular_function AU-rich element binding;GO:0030307,biological_process positive regulation of cell growth;GO:0031125,biological_process rRNA 3'-end processing;GO:0034427,biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034475,biological_process U4 snRNA 3'-end processing;GO:0035327,cellular_component transcriptionally active chromatin;GO:0043488,biological_process regulation of mRNA stability;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045006,biological_process DNA deamination;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0051607,biological_process defense response to virus;GO:0071028,biological_process nuclear mRNA surveillance;GO:0071044,biological_process histone mRNA catabolic process;GO:0071051,biological_process polyadenylation-dependent snoRNA 3'-end processing;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	RRP41, EXOSC4, SKI6; exosome complex component RRP41; K11600	exosome component 4 [Source:HGNC Symbol%3BAcc:HGNC:18189]
ENSG00000075142	212.22	204.72	205.52	215.29	197.97	212.41	0.00456165785948752	7.02762177861666	0.947590102527475	0.997362467475334	7:88205117-88226993:-	SRI	53;GO:0001508,biological_process action potential;GO:0002020,molecular_function protease binding;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005102,molecular_function receptor binding;GO:0005246,molecular_function calcium channel regulator activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005790,cellular_component smooth endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0006810,biological_process transport;GO:0006816,biological_process calcium ion transport;GO:0006880,biological_process intracellular sequestering of iron ion;GO:0006942,biological_process regulation of striated muscle contraction;GO:0007165,biological_process signal transduction;GO:0007507,biological_process heart development;GO:0007517,biological_process muscle organ development;GO:0008016,biological_process regulation of heart contraction;GO:0010459,biological_process negative regulation of heart rate;GO:0010649,biological_process regulation of cell communication by electrical coupling;GO:0010880,biological_process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0030018,cellular_component Z disc;GO:0030315,cellular_component T-tubule;GO:0030424,cellular_component axon;GO:0031982,cellular_component vesicle;GO:0033017,cellular_component sarcoplasmic reticulum membrane;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042584,cellular_component chromaffin granule membrane;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0043679,cellular_component axon terminus;GO:0044325,molecular_function ion channel binding;GO:0044326,cellular_component dendritic spine neck;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051281,biological_process positive regulation of release of sequestered calcium ion into cytosol;GO:0051924,biological_process regulation of calcium ion transport;GO:0055118,biological_process negative regulation of cardiac muscle contraction;GO:0060315,biological_process negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0070062,cellular_component extracellular exosome;GO:0070491,molecular_function repressing transcription factor binding;GO:0086004,biological_process regulation of cardiac muscle cell contraction;GO:1901077,biological_process regulation of relaxation of muscle;GO:1901841,biological_process regulation of high voltage-gated calcium channel activity;GO:1901844,biological_process regulation of cell communication by electrical coupling involved in cardiac conduction;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding	NA	sorcin [Source:HGNC Symbol%3BAcc:HGNC:11292]
ENSG00000113269	42.82	42.11	44.57	43.25	42.43	44.49	0.00518897583021205	5.88852520367377	0.947594763290247	0.997362467475334	5:179911650-180072118:-	RNF130	9;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 130 [Source:HGNC Symbol%3BAcc:HGNC:18280]
ENSG00000126970	11.45	11.62	10.01	12.89	9.99	10.07	0.0141645336183572	2.9532016982562	0.947774367396066	0.997362467475334	X:64915801-65034713:-	ZC4H2	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007528,biological_process neuromuscular junction development;GO:0016020,cellular_component membrane;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0030054,cellular_component cell junction;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0046872,molecular_function metal ion binding	NA	zinc finger C4H2-type containing [Source:HGNC Symbol%3BAcc:HGNC:24931]
ENSG00000108924	2.15	2.58	1.41	1.77	2.90	1.27	0.047264281971107	0.937068567747509	0.947807498592785	0.997362467475334	17:55265011-55325065:+	HLF	15;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048511,biological_process rhythmic process	HLF; hepatic leukemia factor; K09057	HLF%2C PAR bZIP transcription factor [Source:HGNC Symbol%3BAcc:HGNC:4977]
ENSG00000166226	92.48	96.72	90.22	92.94	93.80	94.07	0.00371800282566455	7.33930860534476	0.947811494185199	0.997362467475334	12:69585333-69601570:+	CCT2	30;GO:0000166,molecular_function nucleotide binding;GO:0002199,cellular_component zona pellucida receptor complex;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005832,cellular_component chaperonin-containing T-complex;GO:0005874,cellular_component microtubule;GO:0006457,biological_process protein folding;GO:0007339,biological_process binding of sperm to zona pellucida;GO:0031012,cellular_component extracellular matrix;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0035578,cellular_component azurophil granule lumen;GO:0043209,cellular_component myelin sheath;GO:0043312,biological_process neutrophil degranulation;GO:0044183,molecular_function protein binding involved in protein folding;GO:0044297,cellular_component cell body;GO:0050821,biological_process protein stabilization;GO:0051082,molecular_function unfolded protein binding;GO:0051086,biological_process chaperone mediated protein folding independent of cofactor;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:0051973,biological_process positive regulation of telomerase activity;GO:0070062,cellular_component extracellular exosome;GO:0090666,biological_process scaRNA localization to Cajal body;GO:1901998,biological_process toxin transport;GO:1904851,biological_process positive regulation of establishment of protein localization to telomere;GO:1904871,biological_process positive regulation of protein localization to Cajal body;GO:1904874,biological_process positive regulation of telomerase RNA localization to Cajal body	NA	chaperonin containing TCP1 subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:1615]
ENSG00000166343	1.54	1.25	1.39	1.03	2.09	1.02	0.03818873025263	1.04601153342103	0.94784966813191	0.997362467475334	10:73423578-73433561:-	MSS51	2;GO:0035176,biological_process social behavior;GO:0046872,molecular_function metal ion binding	NA	MSS51 mitochondrial translational activator [Source:HGNC Symbol%3BAcc:HGNC:21000]
ENSG00000117859	65.96	69.31	64.16	65.27	69.92	65.21	0.00402525798590688	7.42353632276579	0.947891615534208	0.997362467475334	1:51577178-51798427:+	OSBPL9	12;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006699,biological_process bile acid biosynthetic process;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0015248,molecular_function sterol transporter activity;GO:0015918,biological_process sterol transport;GO:0016020,cellular_component membrane;GO:0031902,cellular_component late endosome membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	oxysterol binding protein like 9 [Source:HGNC Symbol%3BAcc:HGNC:16386]
ENSG00000111445	22.25	21.93	21.44	22.06	21.45	22.92	-0.00708511148975156	4.70952060445919	0.94791536463056	0.997362467475334	12:118013587-118033130:+	RFC5	24;GO:0000166,molecular_function nucleotide binding;GO:0003677,molecular_function DNA binding;GO:0003689,molecular_function DNA clamp loader activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005663,cellular_component DNA replication factor C complex;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006297,biological_process nucleotide-excision repair, DNA gap filling;GO:0019899,molecular_function enzyme binding;GO:0019985,biological_process translesion synthesis;GO:0031390,cellular_component Ctf18 RFC-like complex;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0042276,biological_process error-prone translesion synthesis;GO:0042769,biological_process DNA damage response, detection of DNA damage;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0070987,biological_process error-free translesion synthesis;GO:1900264,biological_process positive regulation of DNA-directed DNA polymerase activity;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RFC3_5; replication factor C subunit 3/5; K10756	replication factor C subunit 5 [Source:HGNC Symbol%3BAcc:HGNC:9973]
ENSG00000186496	2.42	1.64	2.08	2.31	1.82	1.99	0.0388766296464576	1.35445706392626	0.947967347616127	0.997362467475334	18:35366696-35377337:-	ZNF396	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 396 [Source:HGNC Symbol%3BAcc:HGNC:18824]
ENSG00000149043	1.49	1.62	2.38	1.64	2.09	1.71	0.037390610212436	1.26700136239606	0.947987976881719	0.997362467475334	11:1828306-1837521:+	SYT8	19;GO:0001669,cellular_component acrosomal vesicle;GO:0005509,molecular_function calcium ion binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0006906,biological_process vesicle fusion;GO:0007340,biological_process acrosome reaction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030276,molecular_function clathrin binding;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0048306,molecular_function calcium-dependent protein binding;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter	NA	synaptotagmin 8 [Source:HGNC Symbol%3BAcc:HGNC:19264]
ENSG00000130227	17.64	16.68	16.79	17.19	18.30	15.87	0.00641194174876107	5.83157363987716	0.948041779311792	0.997362467475334	8:21919670-22006585:+	XPO7	12;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005737,cellular_component cytoplasm;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008536,molecular_function Ran GTPase binding;GO:0015031,biological_process protein transport;GO:0051028,biological_process mRNA transport	NA	exportin 7 [Source:HGNC Symbol%3BAcc:HGNC:14108]
ENSG00000135655	13.16	11.65	12.54	11.26	12.64	13.64	0.00754011200635482	5.3246383201963	0.948046261632235	0.997362467475334	12:62260337-62417431:+	USP15	25;GO:0000266,biological_process mitochondrial fission;GO:0003824,molecular_function catalytic activity;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007283,biological_process spermatogenesis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030509,biological_process BMP signaling pathway;GO:0035520,biological_process monoubiquitinated protein deubiquitination;GO:0035616,biological_process histone H2B conserved C-terminal lysine deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0042802,molecular_function identical protein binding;GO:0046332,molecular_function SMAD binding;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0061649,molecular_function ubiquitinated histone binding	NA	ubiquitin specific peptidase 15 [Source:HGNC Symbol%3BAcc:HGNC:12613]
ENSG00000176401	4.83	5.14	4.72	5.43	3.77	5.82	-0.0298755288623724	1.34815084484329	0.948137506430205	0.997362467475334	19:39530989-39532854:-	EID2B	6;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007517,biological_process muscle organ development;GO:0030154,biological_process cell differentiation	NA	EP300 interacting inhibitor of differentiation 2B [Source:HGNC Symbol%3BAcc:HGNC:26796]
ENSG00000131043	13.41	15.54	16.25	13.39	17.13	15.32	-0.0108421886789917	4.37557666888342	0.948203619089554	0.997362467475334	20:36236458-36270918:+	AAR2	1;GO:0000244,biological_process spliceosomal tri-snRNP complex assembly	NA	AAR2 splicing factor homolog [Source:HGNC Symbol%3BAcc:HGNC:15886]
ENSG00000185055	5.10	5.65	5.64	4.59	4.98	6.46	0.0331570332348025	1.3906303386461	0.948251093619399	0.997362467475334	7:105565119-105600875:-	EFCAB10	1;GO:0005509,molecular_function calcium ion binding	NA	EF-hand calcium binding domain 10 [Source:HGNC Symbol%3BAcc:HGNC:34531]
ENSG00000108262	15.31	16.32	14.50	16.20	14.18	15.87	0.00399132508094809	5.25838550332408	0.948269704434374	0.997362467475334	17:29573468-29594054:-	GIT1	12;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0016020,cellular_component membrane;GO:0032403,molecular_function protein complex binding;GO:0032465,biological_process regulation of cytokinesis;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0048013,biological_process ephrin receptor signaling pathway	GIT1; G protein-coupled receptor kinase interactor 1; K05737	GIT ArfGAP 1 [Source:HGNC Symbol%3BAcc:HGNC:4272]
ENSG00000174456	2.19	2.87	2.21	2.03	2.42	2.65	0.0205085469908751	1.38451802833758	0.948489786800913	0.99736923360739	12:110027027-110073686:-	C12orf76	13;GO:0001614,molecular_function purinergic nucleotide receptor activity;GO:0004931,molecular_function extracellular ATP-gated cation channel activity;GO:0005216,molecular_function ion channel activity;GO:0005524,molecular_function ATP binding;GO:0005887,cellular_component integral component of plasma membrane;GO:0006811,biological_process ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0033198,biological_process response to ATP;GO:0035590,biological_process purinergic nucleotide receptor signaling pathway;GO:0060079,biological_process excitatory postsynaptic potential;GO:0098655,biological_process cation transmembrane transport;GO:0098794,cellular_component postsynapse	NA	chromosome 12 open reading frame 76 [Source:HGNC Symbol%3BAcc:HGNC:33790]
ENSG00000130119	10.88	11.11	10.50	10.33	11.38	11.20	-0.00943382968190721	4.26186903299757	0.948531613821495	0.99736923360739	X:54530210-54561071:+	GNL3L	18;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031647,biological_process regulation of protein stability;GO:0032091,biological_process negative regulation of protein binding;GO:0032211,biological_process negative regulation of telomere maintenance via telomerase;GO:0033234,biological_process negative regulation of protein sumoylation;GO:0042254,biological_process ribosome biogenesis;GO:0090073,biological_process positive regulation of protein homodimerization activity;GO:1904816,biological_process positive regulation of protein localization to chromosome, telomeric region	NUG1, GNL3; nuclear GTP-binding protein; K14538	G protein nucleolar 3 like [Source:HGNC Symbol%3BAcc:HGNC:25553]
ENSG00000100479	10.34	10.53	11.45	10.00	11.56	10.85	0.00896324516115537	4.15248995276631	0.94861713757847	0.99736923360739	14:49643554-49688422:-	POLE2	17;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0003677,molecular_function DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0006281,biological_process DNA repair;GO:0008622,cellular_component epsilon DNA polymerase complex;GO:0016604,cellular_component nuclear body;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0042276,biological_process error-prone translesion synthesis;GO:0043231,cellular_component intracellular membrane-bounded organelle	POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]; K02325	DNA polymerase epsilon 2%2C accessory subunit [Source:HGNC Symbol%3BAcc:HGNC:9178]
ENSG00000105669	84.21	88.06	73.68	77.44	87.15	82.29	0.00442956940509964	6.35225256576092	0.948630031805845	0.99736923360739	19:18899513-18919397:-	COPE	20;GO:0000139,cellular_component Golgi membrane;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006891,biological_process intra-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030126,cellular_component COPI vesicle coat;GO:0030133,cellular_component transport vesicle;GO:0030137,cellular_component COPI-coated vesicle;GO:0030663,cellular_component COPI-coated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle	NA	coatomer protein complex subunit epsilon [Source:HGNC Symbol%3BAcc:HGNC:2234]
ENSG00000183048	7.21	9.62	9.18	7.48	10.18	8.31	0.00763588134686361	3.58286877847802	0.948682715930451	0.99736923360739	17:81712235-81721016:+	SLC25A10	31;GO:0005310,molecular_function dicarboxylic acid transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006094,biological_process gluconeogenesis;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006835,biological_process dicarboxylic acid transport;GO:0006839,biological_process mitochondrial transport;GO:0008272,biological_process sulfate transport;GO:0015116,molecular_function sulfate transmembrane transporter activity;GO:0015117,molecular_function thiosulfate transmembrane transporter activity;GO:0015131,molecular_function oxaloacetate transmembrane transporter activity;GO:0015140,molecular_function malate transmembrane transporter activity;GO:0015141,molecular_function succinate transmembrane transporter activity;GO:0015297,molecular_function antiporter activity;GO:0015709,biological_process thiosulfate transport;GO:0015729,biological_process oxaloacetate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0035435,biological_process phosphate ion transmembrane transport;GO:0055085,biological_process transmembrane transport;GO:0070221,biological_process sulfide oxidation, using sulfide:quinone oxidoreductase;GO:0071422,biological_process succinate transmembrane transport;GO:0071423,biological_process malate transmembrane transport;GO:1901677,molecular_function phosphate transmembrane transporter activity;GO:1902356,biological_process oxaloacetate(2-) transmembrane transport;GO:1902358,biological_process sulfate transmembrane transport	SLC25A10, DIC; solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10; K13577	solute carrier family 25 member 10 [Source:HGNC Symbol%3BAcc:HGNC:10980]
ENSG00000143224	13.11	12.78	13.92	11.52	13.85	15.00	-0.00744926407088373	4.51564274564221	0.949029574363124	0.99736923360739	1:161166409-161178013:+	PPOX	16;GO:0004729,molecular_function oxygen-dependent protoporphyrinogen oxidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005758,cellular_component mitochondrial intermembrane space;GO:0006779,biological_process porphyrin-containing compound biosynthetic process;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006783,biological_process heme biosynthetic process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0031304,cellular_component intrinsic component of mitochondrial inner membrane;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0031966,cellular_component mitochondrial membrane;GO:0042493,biological_process response to drug;GO:0046501,biological_process protoporphyrinogen IX metabolic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0055114,biological_process oxidation-reduction process	PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15]; K00231	protoporphyrinogen oxidase [Source:HGNC Symbol%3BAcc:HGNC:9280]
ENSG00000151422	3.12	3.71	2.88	2.96	3.44	3.27	0.00538447986469063	3.0915951213517	0.949055123898463	0.99736923360739	5:108747821-109196841:+	FER	66;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0000278,biological_process mitotic cell cycle;GO:0000790,cellular_component nuclear chromatin;GO:0001932,biological_process regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0006935,biological_process chemotaxis;GO:0007155,biological_process cell adhesion;GO:0007165,biological_process signal transduction;GO:0007260,biological_process tyrosine phosphorylation of STAT protein;GO:0008157,molecular_function protein phosphatase 1 binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0010591,biological_process regulation of lamellipodium assembly;GO:0010762,biological_process regulation of fibroblast migration;GO:0015629,cellular_component actin cytoskeleton;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0031234,cellular_component extrinsic component of cytoplasmic side of plasma membrane;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0032496,biological_process response to lipopolysaccharide;GO:0032869,biological_process cellular response to insulin stimulus;GO:0033007,biological_process negative regulation of mast cell activation involved in immune response;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0034614,biological_process cellular response to reactive oxygen species;GO:0035426,biological_process extracellular matrix-cell signaling;GO:0035556,biological_process intracellular signal transduction;GO:0036006,biological_process cellular response to macrophage colony-stimulating factor stimulus;GO:0036119,biological_process response to platelet-derived growth factor;GO:0038028,biological_process insulin receptor signaling pathway via phosphatidylinositol 3-kinase;GO:0038083,biological_process peptidyl-tyrosine autophosphorylation;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038109,biological_process Kit signaling pathway;GO:0042058,biological_process regulation of epidermal growth factor receptor signaling pathway;GO:0042995,cellular_component cell projection;GO:0043304,biological_process regulation of mast cell degranulation;GO:0044331,biological_process cell-cell adhesion mediated by cadherin;GO:0045087,biological_process innate immune response;GO:0046777,biological_process protein autophosphorylation;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0050904,biological_process diapedesis;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070102,biological_process interleukin-6-mediated signaling pathway	FER, TYK3; tyrosine-protein kinase Fer [EC:2.7.10.2]; K08889	FER tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:3655]
ENSG00000167671	112.29	111.83	108.80	112.93	109.04	112.70	0.0039418956370678	7.21597641559253	0.949097725964209	0.99736923360739	19:4444998-4457822:-	UBXN6	17;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0008150,biological_process biological_process;GO:0016236,biological_process macroautophagy;GO:0019898,cellular_component extrinsic component of membrane;GO:0031901,cellular_component early endosome membrane;GO:0031902,cellular_component late endosome membrane;GO:0032510,biological_process endosome to lysosome transport via multivesicular body sorting pathway;GO:0036503,biological_process ERAD pathway;GO:0043234,cellular_component protein complex;GO:0070062,cellular_component extracellular exosome	UBXN6, UBXD1; UBX domain-containing protein 6; K14011	UBX domain protein 6 [Source:HGNC Symbol%3BAcc:HGNC:14928]
ENSG00000205659	7.76	4.61	3.55	5.82	4.88	6.03	-0.0449038440052021	1.13908567012591	0.94910788249667	0.99736923360739	14:74084795-74201235:+	LIN52	5;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0051726,biological_process regulation of cell cycle;GO:0070176,cellular_component DRM complex	NA	lin-52 DREAM MuvB core complex component [Source:HGNC Symbol%3BAcc:HGNC:19856]
ENSG00000101901	14.76	14.35	14.76	14.61	14.99	14.78	-0.00410480113839316	5.852710876239	0.949108206407375	0.99736923360739	X:111665810-111760649:+	ALG13	16;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004577,molecular_function N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0006508,biological_process proteolysis;GO:0008152,biological_process metabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0016758,molecular_function transferase activity, transferring hexosyl groups;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043541,cellular_component UDP-N-acetylglucosamine transferase complex	ALG13; beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.141]; K07432	ALG13%2C UDP-N-acetylglucosaminyltransferase subunit [Source:HGNC Symbol%3BAcc:HGNC:30881]
ENSG00000143147	8.23	7.46	8.01	8.89	8.26	6.65	0.0123055359685016	3.86472790611435	0.949159973946999	0.99736923360739	1:168079542-168137667:-	GPR161	15;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030666,cellular_component endocytic vesicle membrane;GO:0030819,biological_process positive regulation of cAMP biosynthetic process;GO:0042995,cellular_component cell projection;GO:0055037,cellular_component recycling endosome;GO:0060170,cellular_component ciliary membrane;GO:1901621,biological_process negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	GPR161; G protein-coupled receptor 161; K08439	G protein-coupled receptor 161 [Source:HGNC Symbol%3BAcc:HGNC:23694]
ENSG00000135314	2.97	3.48	4.02	3.67	4.04	3.05	-0.0261270388246578	1.4187657941229	0.949316265303703	0.997449026681469	6:73241313-73310365:-	KHDC1	3;GO:0003723,molecular_function RNA binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	KH homology domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:21366]
ENSG00000177352	12.85	10.98	11.77	10.85	13.05	12.30	-0.00556264521975999	4.08437940180737	0.949641515842684	0.997637466159923	3:49162534-49166321:-	CCDC71	NA	NA	coiled-coil domain containing 71 [Source:HGNC Symbol%3BAcc:HGNC:25760]
ENSG00000084652	33.67	33.55	34.51	35.42	33.94	32.88	0.00526195496792064	5.80412623666689	0.949656352223125	0.997637466159923	1:32179685-32198285:+	TXLNA	10;GO:0005125,molecular_function cytokine activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0006887,biological_process exocytosis;GO:0008283,biological_process cell proliferation;GO:0016020,cellular_component membrane;GO:0019905,molecular_function syntaxin binding;GO:0030372,molecular_function high molecular weight B cell growth factor receptor binding;GO:0042113,biological_process B cell activation	NA	taxilin alpha [Source:HGNC Symbol%3BAcc:HGNC:30685]
ENSG00000132016	1.19	1.44	1.07	1.20	1.07	1.39	0.0107791872488633	1.45934466666362	0.949740300183861	0.997641224183994	19:13882347-13906452:-	C19orf57	4;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0007275,biological_process multicellular organism development	NA	chromosome 19 open reading frame 57 [Source:HGNC Symbol%3BAcc:HGNC:28153]
ENSG00000175906	65.94	61.49	73.23	71.89	59.11	72.42	-0.0055382741414463	5.35242451587739	0.949910949788987	0.997736048377956	17:43398958-43401137:+	ARL4D	12;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0009306,biological_process protein secretion;GO:0016020,cellular_component membrane	NA	ADP ribosylation factor like GTPase 4D [Source:HGNC Symbol%3BAcc:HGNC:656]
ENSG00000128573	3.32	2.46	3.16	2.51	3.32	3.33	-0.0110119247877235	2.92341661795706	0.950069350092934	0.997757450610735	7:114086326-114693772:+	FOXP2	37;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007519,biological_process skeletal muscle tissue development;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009791,biological_process post-embryonic development;GO:0021549,biological_process cerebellum development;GO:0021757,biological_process caudate nucleus development;GO:0021758,biological_process putamen development;GO:0021987,biological_process cerebral cortex development;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0030900,biological_process forebrain development;GO:0033574,biological_process response to testosterone;GO:0040007,biological_process growth;GO:0042297,biological_process vocal learning;GO:0042803,molecular_function protein homodimerization activity;GO:0043010,biological_process camera-type eye development;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048286,biological_process lung alveolus development;GO:0048745,biological_process smooth muscle tissue development;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0050681,molecular_function androgen receptor binding;GO:0060013,biological_process righting reflex;GO:0060501,biological_process positive regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0098582,biological_process innate vocalization behavior	NA	forkhead box P2 [Source:HGNC Symbol%3BAcc:HGNC:13875]
ENSG00000092531	42.07	41.36	43.11	45.58	37.22	45.34	-0.00634325037660044	5.2868578525289	0.950161042963069	0.997757450610735	15:42491232-42545356:+	SNAP23	32;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002553,biological_process histamine secretion by mast cell;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0006810,biological_process transport;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0006903,biological_process vesicle targeting;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016082,biological_process synaptic vesicle priming;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0035579,cellular_component specific granule membrane;GO:0042581,cellular_component specific granule;GO:0042582,cellular_component azurophil granule;GO:0042629,cellular_component mast cell granule;GO:0043005,cellular_component neuron projection;GO:0043312,biological_process neutrophil degranulation;GO:0045202,cellular_component synapse;GO:0061025,biological_process membrane fusion;GO:0070062,cellular_component extracellular exosome;GO:0070821,cellular_component tertiary granule membrane;GO:0098793,cellular_component presynapse	SNAP23; synaptosomal-associated protein 23; K08508	synaptosome associated protein 23 [Source:HGNC Symbol%3BAcc:HGNC:11131]
ENSG00000147526	3.68	3.71	3.61	3.30	3.89	3.96	-0.0109663438424277	3.30257082913992	0.950172466258721	0.997757450610735	8:38728185-38853028:+	TACC1	13;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0008283,biological_process cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0021987,biological_process cerebral cortex development;GO:0030496,cellular_component midbody;GO:0051301,biological_process cell division	NA	transforming acidic coiled-coil containing protein 1 [Source:HGNC Symbol%3BAcc:HGNC:11522]
ENSG00000183260	2.11	2.04	1.73	1.92	2.10	2.05	-0.0383606913042717	1.56146729795432	0.950405905840763	0.997918161833986	20:63861497-63862988:+	ABHD16B	1;GO:0016787,molecular_function hydrolase activity	NA	abhydrolase domain containing 16B [Source:HGNC Symbol%3BAcc:HGNC:16128]
ENSG00000109113	88.52	91.14	82.33	88.06	87.39	89.37	-0.00494171626604857	6.96937721129715	0.950613259555786	0.997957530814106	17:28714280-28718429:-	RAB34	27;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017160,molecular_function Ral GTPase binding;GO:0019882,biological_process antigen processing and presentation;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031982,cellular_component vesicle;GO:0031985,cellular_component Golgi cisterna;GO:0032418,biological_process lysosome localization;GO:0043001,biological_process Golgi to plasma membrane protein transport;GO:0045335,cellular_component phagocytic vesicle;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome;GO:0072659,biological_process protein localization to plasma membrane;GO:0090382,biological_process phagosome maturation;GO:0090385,biological_process phagosome-lysosome fusion	NA	RAB34%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:16519]
ENSG00000112357	7.20	5.88	6.89	5.36	7.03	8.01	-0.0126599069674897	2.91168377824805	0.950647272879163	0.997957530814106	6:136822563-136913937:+	PEX7	16;GO:0001764,biological_process neuron migration;GO:0001958,biological_process endochondral ossification;GO:0005053,molecular_function peroxisome matrix targeting signal-2 binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005782,cellular_component peroxisomal matrix;GO:0005829,cellular_component cytosol;GO:0006625,biological_process protein targeting to peroxisome;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006810,biological_process transport;GO:0007031,biological_process peroxisome organization;GO:0008611,biological_process ether lipid biosynthetic process;GO:0015031,biological_process protein transport;GO:0016558,biological_process protein import into peroxisome matrix;GO:0019899,molecular_function enzyme binding;GO:0042803,molecular_function protein homodimerization activity	PEX7, PTS2R; peroxin-7; K13341	peroxisomal biogenesis factor 7 [Source:HGNC Symbol%3BAcc:HGNC:8860]
ENSG00000143971	13.32	13.04	13.75	12.40	14.20	14.02	-0.00524534916019032	5.2315210495858	0.950838617732682	0.997957530814106	2:67397318-67410545:+	ETAA1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0031297,biological_process replication fork processing;GO:0043539,molecular_function protein serine/threonine kinase activator activity;GO:0043596,cellular_component nuclear replication fork;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:2000001,biological_process regulation of DNA damage checkpoint	NA	ETAA1%2C ATR kinase activator [Source:HGNC Symbol%3BAcc:HGNC:24648]
ENSG00000117450	1228.91	1394.42	1084.41	1145.28	1428.81	1147.59	0.00615856304175334	9.53098084892151	0.950868542500401	0.997957530814106	1:45511035-45523047:-	PRDX1	35;GO:0000302,biological_process response to reactive oxygen species;GO:0001501,biological_process skeletal system development;GO:0001895,biological_process retina homeostasis;GO:0003723,molecular_function RNA binding;GO:0004601,molecular_function peroxidase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005623,cellular_component cell;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006979,biological_process response to oxidative stress;GO:0008283,biological_process cell proliferation;GO:0008379,molecular_function thioredoxin peroxidase activity;GO:0016209,molecular_function antioxidant activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019430,biological_process removal of superoxide radicals;GO:0030101,biological_process natural killer cell activation;GO:0031012,cellular_component extracellular matrix;GO:0032872,biological_process regulation of stress-activated MAPK cascade;GO:0034101,biological_process erythrocyte homeostasis;GO:0034599,biological_process cellular response to oxidative stress;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0042345,biological_process regulation of NF-kappaB import into nucleus;GO:0042470,cellular_component melanosome;GO:0042744,biological_process hydrogen peroxide catabolic process;GO:0042802,molecular_function identical protein binding;GO:0043209,cellular_component myelin sheath;GO:0045296,molecular_function cadherin binding;GO:0045454,biological_process cell redox homeostasis;GO:0051920,molecular_function peroxiredoxin activity;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0098869,biological_process cellular oxidant detoxification	PRDX1; peroxiredoxin 1 [EC:1.11.1.15]; K13279	peroxiredoxin 1 [Source:HGNC Symbol%3BAcc:HGNC:9352]
ENSG00000101421	152.81	142.78	143.59	141.39	154.73	148.17	-0.00394366569801689	6.63207513867195	0.950931933880225	0.997957530814106	20:33811303-33854366:+	CHMP4B	46;GO:0000281,biological_process mitotic cytokinesis;GO:0000815,cellular_component ESCRT III complex;GO:0000920,biological_process cell separation after cytokinesis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0006620,biological_process posttranslational protein targeting to membrane;GO:0006810,biological_process transport;GO:0006914,biological_process autophagy;GO:0006997,biological_process nucleus organization;GO:0007034,biological_process vacuolar transport;GO:0007080,biological_process mitotic metaphase plate congression;GO:0009898,cellular_component cytoplasmic side of plasma membrane;GO:0010458,biological_process exit from mitosis;GO:0010506,biological_process regulation of autophagy;GO:0010824,biological_process regulation of centrosome duplication;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016197,biological_process endosomal transport;GO:0016236,biological_process macroautophagy;GO:0019058,biological_process viral life cycle;GO:0030117,cellular_component membrane coat;GO:0030496,cellular_component midbody;GO:0031468,biological_process nuclear envelope reassembly;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0036258,biological_process multivesicular body assembly;GO:0036438,biological_process maintenance of lens transparency;GO:0039702,biological_process viral budding via host ESCRT complex;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0045296,molecular_function cadherin binding;GO:0046755,biological_process viral budding;GO:0050792,biological_process regulation of viral process;GO:0051260,biological_process protein homooligomerization;GO:0060548,biological_process negative regulation of cell death;GO:0070062,cellular_component extracellular exosome;GO:0090148,biological_process membrane fission;GO:0090611,biological_process ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:1901215,biological_process negative regulation of neuron death;GO:1901673,biological_process regulation of mitotic spindle assembly;GO:1902188,biological_process positive regulation of viral release from host cell;GO:1902902,biological_process negative regulation of autophagosome assembly	NA	charged multivesicular body protein 4B [Source:HGNC Symbol%3BAcc:HGNC:16171]
ENSG00000186868	1.04	0.89	0.28	0.85	0.70	0.62	0.0234511535661817	0.907201594205195	0.951088785249267	0.997957530814106	17:45894381-46028334:+	MAPT	78;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001774,biological_process microglial cell activation;GO:0003677,molecular_function DNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005886,cellular_component plasma membrane;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007165,biological_process signal transduction;GO:0007613,biological_process memory;GO:0008017,molecular_function microtubule binding;GO:0010506,biological_process regulation of autophagy;GO:0010629,biological_process negative regulation of gene expression;GO:0010917,biological_process negative regulation of mitochondrial membrane potential;GO:0015630,cellular_component microtubule cytoskeleton;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0017124,molecular_function SH3 domain binding;GO:0019896,biological_process axonal transport of mitochondrion;GO:0019899,molecular_function enzyme binding;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030673,cellular_component axolemma;GO:0031110,biological_process regulation of microtubule polymerization or depolymerization;GO:0031113,biological_process regulation of microtubule polymerization;GO:0031116,biological_process positive regulation of microtubule polymerization;GO:0031122,biological_process cytoplasmic microtubule organization;GO:0031175,biological_process neuron projection development;GO:0032930,biological_process positive regulation of superoxide anion generation;GO:0033673,biological_process negative regulation of kinase activity;GO:0034185,molecular_function apolipoprotein binding;GO:0034399,cellular_component nuclear periphery;GO:0034452,molecular_function dynactin binding;GO:0034605,biological_process cellular response to heat;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0036477,cellular_component somatodendritic compartment;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0044297,cellular_component cell body;GO:0045298,cellular_component tubulin complex;GO:0045773,biological_process positive regulation of axon extension;GO:0048018,molecular_function receptor agonist activity;GO:0048143,biological_process astrocyte activation;GO:0048312,biological_process intracellular distribution of mitochondria;GO:0048699,biological_process generation of neurons;GO:0050808,biological_process synapse organization;GO:0050848,biological_process regulation of calcium-mediated signaling;GO:0051259,biological_process protein oligomerization;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0051879,molecular_function Hsp90 protein binding;GO:0070507,biological_process regulation of microtubule cytoskeleton organization;GO:0071813,molecular_function lipoprotein particle binding;GO:0072386,biological_process plus-end-directed organelle transport along microtubule;GO:0090140,biological_process regulation of mitochondrial fission;GO:0090258,biological_process negative regulation of mitochondrial fission;GO:0097418,cellular_component neurofibrillary tangle;GO:0097435,biological_process fibril organization;GO:0098930,biological_process axonal transport;GO:0099609,molecular_function microtubule lateral binding;GO:1900034,biological_process regulation of cellular response to heat;GO:1901216,biological_process positive regulation of neuron death;GO:1902474,biological_process positive regulation of protein localization to synapse;GO:1902988,biological_process neurofibrillary tangle assembly;GO:1903748,biological_process negative regulation of establishment of protein localization to mitochondrion;GO:1903829,biological_process positive regulation of cellular protein localization;GO:1904115,cellular_component axon cytoplasm;GO:1905689,biological_process positive regulation of diacylglycerol kinase activity;GO:1990000,biological_process amyloid fibril formation;GO:2001020,biological_process regulation of response to DNA damage stimulus	MAPT, TAU; microtubule-associated protein tau; K04380	microtubule associated protein tau [Source:HGNC Symbol%3BAcc:HGNC:6893]
ENSG00000100345	291.59	295.86	279.64	290.41	296.02	285.59	0.00351421581285919	10.7463746473846	0.95109544175388	0.997957530814106	22:36281280-36388018:-	MYH9	72;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0000212,biological_process meiotic spindle organization;GO:0000904,biological_process cell morphogenesis involved in differentiation;GO:0001525,biological_process angiogenesis;GO:0001701,biological_process in utero embryonic development;GO:0001725,cellular_component stress fiber;GO:0001726,cellular_component ruffle;GO:0001768,biological_process establishment of T cell polarity;GO:0001772,cellular_component immunological synapse;GO:0001931,cellular_component uropod;GO:0003723,molecular_function RNA binding;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005826,cellular_component actomyosin contractile ring;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0005938,cellular_component cell cortex;GO:0006509,biological_process membrane protein ectodomain proteolysis;GO:0006911,biological_process phagocytosis, engulfment;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007520,biological_process myoblast fusion;GO:0008180,cellular_component COP9 signalosome;GO:0008305,cellular_component integrin complex;GO:0008360,biological_process regulation of cell shape;GO:0015031,biological_process protein transport;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016337,biological_process single organismal cell-cell adhesion;GO:0016459,cellular_component myosin complex;GO:0016460,cellular_component myosin II complex;GO:0016887,molecular_function ATPase activity;GO:0019904,molecular_function protein domain specific binding;GO:0030048,biological_process actin filament-based movement;GO:0030220,biological_process platelet formation;GO:0030224,biological_process monocyte differentiation;GO:0030863,cellular_component cortical cytoskeleton;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0031012,cellular_component extracellular matrix;GO:0031032,biological_process actomyosin structure organization;GO:0031252,cellular_component cell leading edge;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031594,cellular_component neuromuscular junction;GO:0032154,cellular_component cleavage furrow;GO:0032506,biological_process cytokinetic process;GO:0032796,biological_process uropod organization;GO:0042641,cellular_component actomyosin;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0043495,molecular_function protein anchor;GO:0043531,molecular_function ADP binding;GO:0043534,biological_process blood vessel endothelial cell migration;GO:0045296,molecular_function cadherin binding;GO:0050900,biological_process leukocyte migration;GO:0051015,molecular_function actin filament binding;GO:0051295,biological_process establishment of meiotic spindle localization;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0097513,cellular_component myosin II filament;GO:1903919,biological_process negative regulation of actin filament severing;GO:1903923,biological_process positive regulation of protein processing in phagocytic vesicle	MYH; myosin heavy chain; K10352	myosin heavy chain 9 [Source:HGNC Symbol%3BAcc:HGNC:7579]
ENSG00000182118	4.61	5.89	3.87	4.20	4.40	5.48	0.0138991710208063	1.45963756843757	0.951308814461187	0.997957530814106	1:231018957-231040246:-	FAM89A	NA	NA	family with sequence similarity 89 member A [Source:HGNC Symbol%3BAcc:HGNC:25057]
ENSG00000143553	84.65	86.66	102.64	94.51	99.08	84.11	-0.00522299906469433	5.2365067321111	0.951330953431359	0.997957530814106	1:153658653-153661830:+	SNAPIN	45;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0007040,biological_process lysosome organization;GO:0007042,biological_process lysosomal lumen acidification;GO:0007268,biological_process chemical synaptic transmission;GO:0007269,biological_process neurotransmitter secretion;GO:0008021,cellular_component synaptic vesicle;GO:0008089,biological_process anterograde axonal transport;GO:0008090,biological_process retrograde axonal transport;GO:0008333,biological_process endosome to lysosome transport;GO:0010977,biological_process negative regulation of neuron projection development;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016079,biological_process synaptic vesicle exocytosis;GO:0016188,biological_process synaptic vesicle maturation;GO:0030054,cellular_component cell junction;GO:0030141,cellular_component secretory granule;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0032418,biological_process lysosome localization;GO:0032438,biological_process melanosome organization;GO:0034629,biological_process cellular protein complex localization;GO:0043393,biological_process regulation of protein binding;GO:0045202,cellular_component synapse;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048489,biological_process synaptic vesicle transport;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0051604,biological_process protein maturation;GO:0072553,biological_process terminal button organization;GO:0097352,biological_process autophagosome maturation;GO:0099078,cellular_component BORC complex;GO:1902774,biological_process late endosome to lysosome transport;GO:1902824,biological_process positive regulation of late endosome to lysosome transport;GO:1904115,cellular_component axon cytoplasm	NA	SNAP associated protein [Source:HGNC Symbol%3BAcc:HGNC:17145]
ENSG00000083838	6.69	6.44	7.46	6.65	7.80	6.51	-0.00716647923988044	3.25152314414941	0.95134504626935	0.997957530814106	19:58474016-58481230:+	ZNF446	12;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 446 [Source:HGNC Symbol%3BAcc:HGNC:21036]
ENSG00000107959	28.90	29.91	29.75	30.12	29.07	29.82	0.00380248564944423	6.69040326150302	0.951425970987285	0.997957530814106	10:3137727-3172841:-	PITRM1	11;GO:0003824,molecular_function catalytic activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006508,biological_process proteolysis;GO:0008047,molecular_function enzyme activator activity;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0043085,biological_process positive regulation of catalytic activity;GO:0046872,molecular_function metal ion binding	NA	pitrilysin metallopeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:17663]
ENSG00000138231	16.70	12.59	15.06	14.96	15.20	14.48	0.0125384935911427	4.61198832030273	0.951490112358289	0.997957530814106	3:138161011-138174949:-	DBR1	10;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0008419,molecular_function RNA lariat debranching enzyme activity;GO:0016787,molecular_function hydrolase activity;GO:0016788,molecular_function hydrolase activity, acting on ester bonds;GO:0046872,molecular_function metal ion binding;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	debranching RNA lariats 1 [Source:HGNC Symbol%3BAcc:HGNC:15594]
ENSG00000094804	12.19	10.86	9.02	12.97	9.75	9.88	-0.010913696140084	4.19137044366727	0.951566597175647	0.997957530814106	17:40287632-40304657:+	CDC6	30;GO:0000076,biological_process DNA replication checkpoint;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006270,biological_process DNA replication initiation;GO:0007049,biological_process cell cycle;GO:0007089,biological_process traversing start control point of mitotic cell cycle;GO:0008156,biological_process negative regulation of DNA replication;GO:0008285,biological_process negative regulation of cell proliferation;GO:0019900,molecular_function kinase binding;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0032467,biological_process positive regulation of cytokinesis;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051233,cellular_component spindle midzone;GO:0051301,biological_process cell division;GO:0051984,biological_process positive regulation of chromosome segregation;GO:1904117,biological_process cellular response to vasopressin;GO:1904385,biological_process cellular response to angiotensin	CDC6; cell division control protein 6; K02213	cell division cycle 6 [Source:HGNC Symbol%3BAcc:HGNC:1744]
ENSG00000166359	1.21	1.90	1.87	1.23	1.98	1.69	0.0196400075164149	1.34205536507218	0.951568946645916	0.997957530814106	19:33132089-33175795:+	WDR88	NA	NA	WD repeat domain 88 [Source:HGNC Symbol%3BAcc:HGNC:26999]
ENSG00000197912	19.36	22.05	19.07	19.17	22.55	19.42	-0.0068302940216335	6.07296004372978	0.952034825251266	0.998295758939528	16:89490916-89557768:+	SPG7	22;GO:0000166,molecular_function nucleotide binding;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005745,cellular_component m-AAA complex;GO:0006508,biological_process proteolysis;GO:0006851,biological_process mitochondrial calcium ion transport;GO:0007005,biological_process mitochondrion organization;GO:0007399,biological_process nervous system development;GO:0008089,biological_process anterograde axonal transport;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0031966,cellular_component mitochondrial membrane;GO:0046872,molecular_function metal ion binding;GO:0051082,molecular_function unfolded protein binding;GO:1904115,cellular_component axon cytoplasm	NA	SPG7%2C paraplegin matrix AAA peptidase subunit [Source:HGNC Symbol%3BAcc:HGNC:11237]
ENSG00000242612	12.51	9.33	10.32	9.67	10.45	12.68	-0.0100607615030184	3.80552749541767	0.952052299550966	0.998295758939528	16:401825-412487:+	DECR2	11;GO:0005102,molecular_function receptor binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006636,biological_process unsaturated fatty acid biosynthetic process;GO:0008670,molecular_function 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0016491,molecular_function oxidoreductase activity;GO:0019166,molecular_function trans-2-enoyl-CoA reductase (NADPH) activity;GO:0033540,biological_process fatty acid beta-oxidation using acyl-CoA oxidase;GO:0055114,biological_process oxidation-reduction process	DECR2; peroxisomal 2,4-dienoyl-CoA reductase [EC:1.3.1.34]; K13237	2%2C4-dienoyl-CoA reductase 2 [Source:HGNC Symbol%3BAcc:HGNC:2754]
ENSG00000274750	5.54	6.79	7.04	8.26	5.95	5.69	-0.0314277780375278	1.49227493567628	0.952273405227184	0.998303495292115	6:26224198-26227473:+	HIST1H3E	32;GO:0000183,biological_process chromatin silencing at rDNA;GO:0000228,cellular_component nuclear chromosome;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000786,cellular_component nucleosome;GO:0000788,cellular_component nuclear nucleosome;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006325,biological_process chromatin organization;GO:0006334,biological_process nucleosome assembly;GO:0006335,biological_process DNA replication-dependent nucleosome assembly;GO:0007596,biological_process blood coagulation;GO:0016020,cellular_component membrane;GO:0031492,molecular_function nucleosomal DNA binding;GO:0032200,biological_process telomere organization;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042393,molecular_function histone binding;GO:0043234,cellular_component protein complex;GO:0044267,biological_process cellular protein metabolic process;GO:0045296,molecular_function cadherin binding;GO:0045652,biological_process regulation of megakaryocyte differentiation;GO:0045814,biological_process negative regulation of gene expression, epigenetic;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046982,molecular_function protein heterodimerization activity;GO:0051290,biological_process protein heterotetramerization;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0060968,biological_process regulation of gene silencing;GO:0070062,cellular_component extracellular exosome;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	NA	histone cluster 1 H3 family member e [Source:HGNC Symbol%3BAcc:HGNC:4769]
ENSG00000132466	20.40	20.91	21.11	20.76	21.04	20.97	0.00364762352117321	7.36072153687341	0.952312268053935	0.998303495292115	4:73073375-73258798:-	ANKRD17	21;GO:0000785,cellular_component chromatin;GO:0001955,biological_process blood vessel maturation;GO:0002376,biological_process immune system process;GO:0003676,molecular_function nucleic acid binding;GO:0003682,molecular_function chromatin binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006275,biological_process regulation of DNA replication;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0031965,cellular_component nuclear membrane;GO:0042742,biological_process defense response to bacterium;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087,biological_process innate immune response;GO:0045787,biological_process positive regulation of cell cycle;GO:0051151,biological_process negative regulation of smooth muscle cell differentiation;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1900245,biological_process positive regulation of MDA-5 signaling pathway;GO:1900246,biological_process positive regulation of RIG-I signaling pathway	NA	ankyrin repeat domain 17 [Source:HGNC Symbol%3BAcc:HGNC:23575]
ENSG00000268043	5.01	4.70	4.95	5.14	4.70	5.04	-0.00652822582804886	4.44002862616534	0.952400755876949	0.998303495292115	1:146938743-146996202:+	NBPF12	2;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	NA	NBPF member 12 [Source:HGNC Symbol%3BAcc:HGNC:24297]
ENSG00000154319	4.62	3.87	3.44	3.97	3.19	5.15	-0.0341559852676337	1.46454270977187	0.952402478218449	0.998303495292115	8:11421462-11474715:-	FAM167A	2;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum	NA	family with sequence similarity 167 member A [Source:HGNC Symbol%3BAcc:HGNC:15549]
ENSG00000152669	3.13	2.16	2.91	2.61	2.71	2.85	0.0378170747583289	1.62075551769252	0.952461797691495	0.998303495292115	5:55231151-55233680:-	CCNO	11;GO:0004844,molecular_function uracil DNA N-glycosylase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006284,biological_process base-excision repair;GO:0007049,biological_process cell cycle;GO:0030030,biological_process cell projection organization;GO:0042493,biological_process response to drug;GO:0051301,biological_process cell division;GO:0060271,biological_process cilium morphogenesis;GO:1903251,biological_process multi-ciliated epithelial cell differentiation	NA	cyclin O [Source:HGNC Symbol%3BAcc:HGNC:18576]
ENSG00000180448	0.64	0.84	0.63	0.69	0.80	0.58	0.0155213306204947	1.53792031396968	0.952613250593913	0.998303995790456	19:1065922-1086628:+	ARHGAP45	18;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0032587,cellular_component ruffle membrane;GO:0034774,cellular_component secretory granule lumen;GO:0035556,biological_process intracellular signal transduction;GO:0035578,cellular_component azurophil granule lumen;GO:0042995,cellular_component cell projection;GO:0043312,biological_process neutrophil degranulation;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 45 [Source:HGNC Symbol%3BAcc:HGNC:17102]
ENSG00000172273	11.65	11.97	13.60	12.44	12.23	12.69	0.00784131552130119	4.33787368824193	0.952623123349549	0.998303995790456	11:119121586-119136044:+	HINFP	32;GO:0000077,biological_process DNA damage checkpoint;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006281,biological_process DNA repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0010468,biological_process regulation of gene expression;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0015030,cellular_component Cajal body;GO:0019899,molecular_function enzyme binding;GO:0030054,cellular_component cell junction;GO:0042393,molecular_function histone binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045184,biological_process establishment of protein localization;GO:0045445,biological_process myoblast differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	histone H4 transcription factor [Source:HGNC Symbol%3BAcc:HGNC:17850]
ENSG00000184986	1.55	1.10	2.92	1.49	1.35	2.72	0.033045448246592	0.971554043310298	0.952780584068099	0.99838471973977	14:105526602-105530202:+	TMEM121	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 121 [Source:HGNC Symbol%3BAcc:HGNC:20511]
ENSG00000117395	63.32	58.86	58.45	58.21	60.09	63.31	0.0048838896054751	6.03566805755544	0.952862485695168	0.998386261073193	1:43164174-43270936:-	EBNA1BP2	9;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0034399,cellular_component nuclear periphery;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis	NA	EBNA1 binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15531]
ENSG00000218891	15.88	15.25	15.89	15.54	16.10	15.60	0.00718970945743915	4.73701285240782	0.952993725304686	0.998428423705995	19:55576769-55580845:-	ZNF579	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 579 [Source:HGNC Symbol%3BAcc:HGNC:26646]
ENSG00000137691	3.49	2.36	3.12	2.55	2.77	3.97	-0.0249365208733036	1.47029778696043	0.953063594013722	0.998428423705995	11:102047442-102084560:+	C11orf70	NA	NA	chromosome 11 open reading frame 70 [Source:HGNC Symbol%3BAcc:HGNC:28188]
ENSG00000159055	14.65	14.63	15.69	14.03	16.71	14.99	-0.0100609051086332	3.42336394172939	0.953276966836511	0.998531508956159	21:32268218-32279069:-	MIS18A	16;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0008150,biological_process biological_process;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0044030,biological_process regulation of DNA methylation;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	MIS18 kinetochore protein A [Source:HGNC Symbol%3BAcc:HGNC:1286]
ENSG00000154165	10.59	9.47	10.49	10.47	10.60	9.64	0.0128651892393942	3.48600801147698	0.953322880257749	0.998531508956159	3:98531898-98533150:+	GPR15	9;GO:0004871,molecular_function signal transducer activity;GO:0004930,molecular_function G-protein coupled receptor activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0072678,biological_process T cell migration	NA	G protein-coupled receptor 15 [Source:HGNC Symbol%3BAcc:HGNC:4469]
ENSG00000198482	3.99	3.77	4.10	4.26	3.64	4.15	-0.00741211557754577	3.45614814530716	0.953406456810982	0.998534791460911	19:52527651-52564464:+	ZNF808	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 808 [Source:HGNC Symbol%3BAcc:HGNC:33230]
ENSG00000119630	5.64	2.63	5.47	6.19	1.67	5.71	0.0407953834185677	1.81787402833348	0.953563450779918	0.998594915727489	14:74941833-74955784:-	PGF	29;GO:0001525,biological_process angiogenesis;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001666,biological_process response to hypoxia;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002040,biological_process sprouting angiogenesis;GO:0005172,molecular_function vascular endothelial growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007565,biological_process female pregnancy;GO:0008083,molecular_function growth factor activity;GO:0008201,molecular_function heparin binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0030154,biological_process cell differentiation;GO:0031100,biological_process organ regeneration;GO:0032870,biological_process cellular response to hormone stimulus;GO:0042493,biological_process response to drug;GO:0042803,molecular_function protein homodimerization activity;GO:0045766,biological_process positive regulation of angiogenesis;GO:0046982,molecular_function protein heterodimerization activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0050930,biological_process induction of positive chemotaxis;GO:0051781,biological_process positive regulation of cell division;GO:0060688,biological_process regulation of morphogenesis of a branching structure;GO:0060754,biological_process positive regulation of mast cell chemotaxis	PGF; placenta growth factor; K16859	placental growth factor [Source:HGNC Symbol%3BAcc:HGNC:8893]
ENSG00000149925	609.17	622.45	601.55	610.08	631.25	611.10	-0.00335579764265204	10.085177961722	0.953648606630585	0.998594915727489	16:30053089-30070457:+	ALDOA	39;GO:0002576,biological_process platelet degranulation;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0003824,molecular_function catalytic activity;GO:0004332,molecular_function fructose-bisphosphate aldolase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006000,biological_process fructose metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0006754,biological_process ATP biosynthetic process;GO:0006941,biological_process striated muscle contraction;GO:0007015,biological_process actin filament organization;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008360,biological_process regulation of cell shape;GO:0015629,cellular_component actin cytoskeleton;GO:0015631,molecular_function tubulin binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0030388,biological_process fructose 1,6-bisphosphate metabolic process;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031430,cellular_component M band;GO:0031674,cellular_component I band;GO:0034774,cellular_component secretory granule lumen;GO:0042802,molecular_function identical protein binding;GO:0043312,biological_process neutrophil degranulation;GO:0045296,molecular_function cadherin binding;GO:0046716,biological_process muscle cell cellular homeostasis;GO:0051289,biological_process protein homotetramerization;GO:0061621,biological_process canonical glycolysis;GO:0070061,molecular_function fructose binding;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen;GO:1904813,cellular_component ficolin-1-rich granule lumen	ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]; K01623	aldolase%2C fructose-bisphosphate A [Source:HGNC Symbol%3BAcc:HGNC:414]
ENSG00000147419	5.64	4.73	4.23	5.38	4.36	4.72	0.031180699522604	1.67422838329611	0.953789520162734	0.998594915727489	8:27733310-27772653:-	CCDC25	2;GO:0005515,molecular_function protein binding;GO:0070062,cellular_component extracellular exosome	NA	coiled-coil domain containing 25 [Source:HGNC Symbol%3BAcc:HGNC:25591]
ENSG00000158092	41.71	40.36	43.09	42.42	40.23	44.00	-0.00419876879175311	5.61780374473842	0.953896336243795	0.998594915727489	3:136862207-136949823:+	NCK1	49;GO:0000164,cellular_component protein phosphatase type 1 complex;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006417,biological_process regulation of translation;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006930,biological_process substrate-dependent cell migration, cell extension;GO:0007015,biological_process actin filament organization;GO:0007172,biological_process signal complex assembly;GO:0008093,molecular_function cytoskeletal adaptor activity;GO:0010976,biological_process positive regulation of neuron projection development;GO:0012506,cellular_component vesicle membrane;GO:0016477,biological_process cell migration;GO:0019904,molecular_function protein domain specific binding;GO:0030032,biological_process lamellipodium assembly;GO:0030159,molecular_function receptor signaling complex scaffold activity;GO:0030334,biological_process regulation of cell migration;GO:0030674,molecular_function protein binding, bridging;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0033137,biological_process negative regulation of peptidyl-serine phosphorylation;GO:0036493,biological_process positive regulation of translation in response to endoplasmic reticulum stress;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042110,biological_process T cell activation;GO:0045296,molecular_function cadherin binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046875,molecular_function ephrin receptor binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051707,biological_process response to other organism;GO:0060548,biological_process negative regulation of cell death;GO:0070262,biological_process peptidyl-serine dephosphorylation;GO:0071074,molecular_function eukaryotic initiation factor eIF2 binding;GO:1902237,biological_process positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903676,biological_process positive regulation of cap-dependent translational initiation;GO:1903679,biological_process positive regulation of cap-independent translational initiation;GO:1903898,biological_process negative regulation of PERK-mediated unfolded protein response;GO:1903912,biological_process negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:1990441,biological_process negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	NCK1; NCK adaptor protein 1; K07365	NCK adaptor protein 1 [Source:HGNC Symbol%3BAcc:HGNC:7664]
ENSG00000042088	11.68	12.39	11.89	11.74	13.44	10.89	0.00651573319067525	4.66675149491076	0.953949701879932	0.998594915727489	14:89954938-90044768:+	TDP1	17;GO:0000012,biological_process single strand break repair;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008081,molecular_function phosphoric diester hydrolase activity;GO:0016787,molecular_function hydrolase activity;GO:0017005,molecular_function 3'-tyrosyl-DNA phosphodiesterase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	NA	tyrosyl-DNA phosphodiesterase 1 [Source:HGNC Symbol%3BAcc:HGNC:18884]
ENSG00000161057	104.97	111.57	102.47	103.89	112.66	105.85	-0.00463022087712659	7.12947981269118	0.954004327988022	0.998594915727489	7:103344253-103369395:+	PSMC2	53;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000209,biological_process protein polyubiquitination;GO:0000502,cellular_component proteasome complex;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0001649,biological_process osteoblast differentiation;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017025,molecular_function TBP-class protein binding;GO:0022624,cellular_component proteasome accessory complex;GO:0030163,biological_process protein catabolic process;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031595,cellular_component nuclear proteasome complex;GO:0031597,cellular_component cytosolic proteasome complex;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0034774,cellular_component secretory granule lumen;GO:0036402,molecular_function proteasome-activating ATPase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043312,biological_process neutrophil degranulation;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045899,biological_process positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1901800,biological_process positive regulation of proteasomal protein catabolic process;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation;GO:1904813,cellular_component ficolin-1-rich granule lumen	PSMC2, RPT1; 26S proteasome regulatory subunit T1; K03061	proteasome 26S subunit%2C ATPase 2 [Source:HGNC Symbol%3BAcc:HGNC:9548]
ENSG00000277972	52.64	42.89	40.57	43.82	47.58	46.88	-0.00630164770328267	4.139226712647	0.954026996343534	0.998594915727489	17:38730234-38735044:+	CISD3	5;GO:0005739,cellular_component mitochondrion;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051537,molecular_function 2 iron, 2 sulfur cluster binding	NA	CDGSH iron sulfur domain 3 [Source:HGNC Symbol%3BAcc:HGNC:27578]
ENSG00000159461	40.21	37.57	41.22	38.71	38.46	42.50	0.00500753040829223	6.33644258744151	0.954341195432563	0.998771552271016	16:56361451-56425538:-	AMFR	44;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0006457,biological_process protein folding;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006928,biological_process movement of cell or subcellular component;GO:0007165,biological_process signal transduction;GO:0007568,biological_process aging;GO:0007611,biological_process learning or memory;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030425,cellular_component dendrite;GO:0030426,cellular_component growth cone;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030674,molecular_function protein binding, bridging;GO:0030968,biological_process endoplasmic reticulum unfolded protein response;GO:0032092,biological_process positive regulation of protein binding;GO:0034450,molecular_function ubiquitin-ubiquitin ligase activity;GO:0036503,biological_process ERAD pathway;GO:0036513,cellular_component Derlin-1 retrotranslocation complex;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043025,cellular_component neuronal cell body;GO:0043234,cellular_component protein complex;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0046872,molecular_function metal ion binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051087,molecular_function chaperone binding;GO:0051259,biological_process protein oligomerization;GO:0051865,biological_process protein autoubiquitination;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904288,molecular_function BAT3 complex binding;GO:1904380,biological_process endoplasmic reticulum mannose trimming;GO:1990381,molecular_function ubiquitin-specific protease binding	AMFR, GP78; autocrine motility factor receptor [EC:2.3.2.27]; K10636	autocrine motility factor receptor [Source:HGNC Symbol%3BAcc:HGNC:463]
ENSG00000167772	16.88	11.23	14.53	17.00	8.49	17.99	-0.0130623836927211	4.19031005041954	0.954422846956089	0.998771552271016	19:8363288-8374373:+	ANGPTL4	18;GO:0001525,biological_process angiogenesis;GO:0001666,biological_process response to hypoxia;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0007275,biological_process multicellular organism development;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030154,biological_process cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045766,biological_process positive regulation of angiogenesis;GO:0051005,biological_process negative regulation of lipoprotein lipase activity;GO:0051260,biological_process protein homooligomerization;GO:0070328,biological_process triglyceride homeostasis;GO:0072562,cellular_component blood microparticle;GO:2000352,biological_process negative regulation of endothelial cell apoptotic process	ANGPTL4, PGAR; angiopoietin-like 4; K08767	angiopoietin like 4 [Source:HGNC Symbol%3BAcc:HGNC:16039]
ENSG00000106526	31.62	33.28	28.86	32.96	32.74	28.32	0.00529298363474804	4.87829538719613	0.954491115251521	0.998771552271016	7:150243915-150323725:-	ACTR3C	9;GO:0000166,molecular_function nucleotide binding;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0005524,molecular_function ATP binding;GO:0005885,cellular_component Arp2/3 protein complex;GO:0007015,biological_process actin filament organization;GO:0008150,biological_process biological_process;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0070062,cellular_component extracellular exosome	NA	ARP3 actin related protein 3 homolog C [Source:HGNC Symbol%3BAcc:HGNC:37282]
ENSG00000130714	25.78	23.96	27.67	24.50	27.20	26.17	0.00620142452905628	5.95091929790897	0.954517596438497	0.998771552271016	9:131502901-131523806:+	POMT1	20;GO:0000030,molecular_function mannosyltransferase activity;GO:0001669,cellular_component acrosomal vesicle;GO:0004169,molecular_function dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030198,biological_process extracellular matrix organization;GO:0035269,biological_process protein O-linked mannosylation;GO:0046872,molecular_function metal ion binding;GO:0071712,biological_process ER-associated misfolded protein catabolic process;GO:0097502,biological_process mannosylation;GO:1904100,biological_process positive regulation of protein O-linked glycosylation	POMT, pmt; dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]; K00728	protein O-mannosyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:9202]
ENSG00000090006	52.50	47.19	53.41	52.93	47.25	54.66	-0.00393606196767767	8.08971843382091	0.954938701072985	0.999127958228167	19:40592882-40629818:+	LTBP4	21;GO:0001558,biological_process regulation of cell growth;GO:0005024,molecular_function transforming growth factor beta-activated receptor activity;GO:0005178,molecular_function integrin binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006457,biological_process protein folding;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0019838,molecular_function growth factor binding;GO:0030162,biological_process regulation of proteolysis;GO:0030252,biological_process growth hormone secretion;GO:0031012,cellular_component extracellular matrix;GO:0045595,biological_process regulation of cell differentiation;GO:0046879,biological_process hormone secretion;GO:0050431,molecular_function transforming growth factor beta binding;GO:0070062,cellular_component extracellular exosome	NA	latent transforming growth factor beta binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:6717]
ENSG00000132640	6.72	6.29	7.00	7.36	7.07	5.97	-0.00961274837403272	3.42159833369874	0.95519304891208	0.999309845440004	20:11890722-11926609:+	BTBD3	11;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007399,biological_process nervous system development;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0021987,biological_process cerebral cortex development;GO:0030162,biological_process regulation of proteolysis;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048813,biological_process dendrite morphogenesis	NA	BTB domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:15854]
ENSG00000182359	5.27	5.20	3.84	4.47	5.34	4.72	-0.0145216438733558	3.19414787293773	0.955413886774368	0.999456647272057	11:106051097-106077765:-	KBTBD3	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch repeat and BTB domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:22934]
ENSG00000085117	41.59	36.78	41.27	45.91	35.01	40.32	-0.00465129639048929	5.37679120312965	0.955653856902367	0.999559177310123	11:44564426-44620363:+	CD82	7;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	KAI1, CD82, TSPAN27; CD82 antigen; K06509	CD82 molecule [Source:HGNC Symbol%3BAcc:HGNC:6210]
ENSG00000099365	3.19	3.36	4.29	3.54	3.84	3.40	0.0255023602071955	1.7793573990864	0.955693189945876	0.999559177310123	16:30989255-31010661:-	STX1B	42;GO:0000149,molecular_function SNARE binding;GO:0001956,biological_process positive regulation of neurotransmitter secretion;GO:0005102,molecular_function receptor binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006836,biological_process neurotransmitter transport;GO:0006886,biological_process intracellular protein transport;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0008021,cellular_component synaptic vesicle;GO:0010468,biological_process regulation of gene expression;GO:0010807,biological_process regulation of synaptic vesicle priming;GO:0010977,biological_process negative regulation of neuron projection development;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016081,biological_process synaptic vesicle docking;GO:0016192,biological_process vesicle-mediated transport;GO:0017157,biological_process regulation of exocytosis;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0031201,cellular_component SNARE complex;GO:0031629,biological_process synaptic vesicle fusion to presynaptic active zone membrane;GO:0042734,cellular_component presynaptic membrane;GO:0048278,biological_process vesicle docking;GO:0048787,cellular_component presynaptic active zone membrane;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0060025,biological_process regulation of synaptic activity;GO:0061669,biological_process spontaneous neurotransmitter secretion;GO:0072657,biological_process protein localization to membrane;GO:0098793,cellular_component presynapse;GO:0098967,biological_process exocytic insertion of neurotransmitter receptor to postsynaptic membrane;GO:1903422,biological_process negative regulation of synaptic vesicle recycling;GO:1904050,biological_process positive regulation of spontaneous neurotransmitter secretion;GO:1905302,biological_process negative regulation of macropinocytosis;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential	NA	syntaxin 1B [Source:HGNC Symbol%3BAcc:HGNC:18539]
ENSG00000132963	141.59	144.36	125.97	139.48	136.80	139.97	-0.00574991856101419	5.87135833671244	0.955838142531364	0.999559177310123	13:28659103-28678925:+	POMP	10;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043248,biological_process proteasome assembly	POMP, UMP1; proteasome maturation protein; K11599	proteasome maturation protein [Source:HGNC Symbol%3BAcc:HGNC:20330]
ENSG00000119537	31.34	31.76	33.48	33.23	28.78	34.95	0.00528954465345344	5.01416344153627	0.955850308206559	0.999559177310123	18:63327725-63367510:-	KDSR	12;GO:0005615,cellular_component extracellular space;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006629,biological_process lipid metabolic process;GO:0006665,biological_process sphingolipid metabolic process;GO:0006666,biological_process 3-keto-sphinganine metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0030148,biological_process sphingolipid biosynthetic process;GO:0047560,molecular_function 3-dehydrosphinganine reductase activity;GO:0055114,biological_process oxidation-reduction process	KDSR; 3-dehydrosphinganine reductase [EC:1.1.1.102]; K04708	3-ketodihydrosphingosine reductase [Source:HGNC Symbol%3BAcc:HGNC:4021]
ENSG00000138385	130.34	130.18	123.47	123.73	134.10	130.26	-0.00388714572511671	7.36703724790003	0.955962711506895	0.999559177310123	2:169791932-169812064:+	SSB	21;GO:0000049,molecular_function tRNA binding;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001682,biological_process tRNA 5'-leader removal;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006396,biological_process RNA processing;GO:0006400,biological_process tRNA modification;GO:0006409,biological_process tRNA export from nucleus;GO:0008033,biological_process tRNA processing;GO:0008266,molecular_function poly(U) RNA binding;GO:0008334,biological_process histone mRNA metabolic process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0042780,biological_process tRNA 3'-end processing;GO:0071045,biological_process nuclear histone mRNA catabolic process;GO:0075522,biological_process IRES-dependent viral translational initiation;GO:1903608,biological_process protein localization to cytoplasmic stress granule;GO:1990825,molecular_function sequence-specific mRNA binding	LA, SSB; lupus La protein; K11090	Sjogren syndrome antigen B [Source:HGNC Symbol%3BAcc:HGNC:11316]
ENSG00000152700	44.90	43.84	40.60	42.85	44.07	42.94	0.00519982738035997	4.88014078083928	0.956072410030878	0.999559177310123	5:134601143-134649271:-	SAR1B	20;GO:0000166,molecular_function nucleotide binding;GO:0002474,biological_process antigen processing and presentation of peptide antigen via MHC class I;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046872,molecular_function metal ion binding;GO:0048208,biological_process COPII vesicle coating	SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]; K07953	secretion associated Ras related GTPase 1B [Source:HGNC Symbol%3BAcc:HGNC:10535]
ENSG00000090238	6.23	6.89	7.52	6.15	7.75	6.62	0.0194585911003074	1.83711350329565	0.956105730099547	0.999559177310123	16:30092313-30096915:-	YPEL3	4;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0046872,molecular_function metal ion binding;GO:2000774,biological_process positive regulation of cellular senescence	NA	yippee like 3 [Source:HGNC Symbol%3BAcc:HGNC:18327]
ENSG00000083720	36.35	43.45	35.72	36.19	41.75	37.94	0.00316771464226072	5.91822661440233	0.956192438236027	0.999559177310123	5:41730064-41870519:-	OXCT1	21;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0007420,biological_process brain development;GO:0007507,biological_process heart development;GO:0007584,biological_process response to nutrient;GO:0008152,biological_process metabolic process;GO:0008260,molecular_function 3-oxoacid CoA-transferase activity;GO:0008410,molecular_function CoA-transferase activity;GO:0009725,biological_process response to hormone;GO:0014823,biological_process response to activity;GO:0016740,molecular_function transferase activity;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042182,biological_process ketone catabolic process;GO:0042493,biological_process response to drug;GO:0042594,biological_process response to starvation;GO:0042803,molecular_function protein homodimerization activity;GO:0045471,biological_process response to ethanol;GO:0046950,biological_process cellular ketone body metabolic process;GO:0046952,biological_process ketone body catabolic process;GO:0060612,biological_process adipose tissue development	OXCT; 3-oxoacid CoA-transferase [EC:2.8.3.5]; K01027	3-oxoacid CoA-transferase 1 [Source:HGNC Symbol%3BAcc:HGNC:8527]
ENSG00000113048	23.28	21.66	20.44	23.24	20.45	21.98	0.00620794048718792	4.89081351512949	0.956236625357102	0.999559177310123	5:72219408-72320646:-	MRPS27	7;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S27 [Source:HGNC Symbol%3BAcc:HGNC:14512]
ENSG00000054611	19.02	15.27	15.62	15.94	18.52	16.18	-0.00377887698053656	4.91740618385024	0.956671682132018	0.999791138798714	22:46762616-47175699:+	TBC1D22A	10;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0006886,biological_process intracellular protein transport;GO:0012505,cellular_component endomembrane system;GO:0017137,molecular_function Rab GTPase binding;GO:0031338,biological_process regulation of vesicle fusion;GO:0042803,molecular_function protein homodimerization activity;GO:0071889,molecular_function 14-3-3 protein binding;GO:0090630,biological_process activation of GTPase activity	NA	TBC1 domain family member 22A [Source:HGNC Symbol%3BAcc:HGNC:1309]
ENSG00000129003	7.95	7.51	7.88	8.02	8.03	7.55	-0.0030347767609173	6.4672338809021	0.956809281231817	0.999791138798714	15:61852388-62060473:-	VPS13C	9;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005829,cellular_component cytosol;GO:0006895,biological_process Golgi to endosome transport;GO:0007005,biological_process mitochondrion organization;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome;GO:1905090,biological_process negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization	NA	vacuolar protein sorting 13 homolog C [Source:HGNC Symbol%3BAcc:HGNC:23594]
ENSG00000152520	4.64	5.14	5.01	4.95	4.93	5.07	-0.0101005569705599	3.73704946664102	0.956846883088801	0.999791138798714	13:28138505-28295335:+	PAN3	19;GO:0000166,molecular_function nucleotide binding;GO:0000288,biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,biological_process nuclear-transcribed mRNA poly(A) tail shortening;GO:0000290,biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0006605,biological_process protein targeting;GO:0010606,biological_process positive regulation of cytoplasmic mRNA processing body assembly;GO:0031251,cellular_component PAN complex;GO:0046872,molecular_function metal ion binding;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3; K12572	PAN3 poly(A) specific ribonuclease subunit [Source:HGNC Symbol%3BAcc:HGNC:29991]
ENSG00000148296	21.98	22.24	19.91	19.98	20.66	23.63	0.00436970954779409	4.54434239634351	0.956855998835326	0.999791138798714	9:133328773-133336398:-	SURF6	11;GO:0001652,cellular_component granular component;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0042274,biological_process ribosomal small subunit biogenesis	NA	surfeit 6 [Source:HGNC Symbol%3BAcc:HGNC:11478]
ENSG00000074800	3859.68	4152.92	3745.57	3932.68	4086.41	3863.45	-0.0034085143659911	12.3258254575821	0.956938803319178	0.999791138798714	1:8861001-8879249:-	ENO1	37;GO:0000015,cellular_component phosphopyruvate hydratase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000287,molecular_function magnesium ion binding;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004634,molecular_function phosphopyruvate hydratase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009615,biological_process response to virus;GO:0009986,cellular_component cell surface;GO:0010756,biological_process positive regulation of plasminogen activation;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0030308,biological_process negative regulation of cell growth;GO:0031430,cellular_component M band;GO:0042803,molecular_function protein homodimerization activity;GO:0045296,molecular_function cadherin binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045933,biological_process positive regulation of muscle contraction;GO:0046872,molecular_function metal ion binding;GO:0051020,molecular_function GTPase binding;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome;GO:0099738,cellular_component cell cortex region;GO:1903298,biological_process negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:2001171,biological_process positive regulation of ATP biosynthetic process	ENO, eno; enolase [EC:4.2.1.11]; K01689	enolase 1 [Source:HGNC Symbol%3BAcc:HGNC:3350]
ENSG00000008128	10.29	8.94	9.08	9.77	9.64	9.08	0.00844556408503725	4.52728508671879	0.956971864890155	0.999791138798714	1:1702729-1724324:-	CDK11A	18;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0001558,biological_process regulation of cell growth;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004693,molecular_function cyclin-dependent protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0050684,biological_process regulation of mRNA processing	NA	cyclin dependent kinase 11A [Source:HGNC Symbol%3BAcc:HGNC:1730]
ENSG00000113387	503.05	510.19	513.37	526.83	505.21	503.41	0.00333694656251107	7.81281503027957	0.957022340385589	0.999791138798714	5:32531632-32604079:+	SUB1	23;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005667,cellular_component transcription factor complex;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0032508,biological_process DNA duplex unwinding;GO:0033613,molecular_function activating transcription factor binding;GO:0042802,molecular_function identical protein binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051260,biological_process protein homooligomerization;GO:0060261,biological_process positive regulation of transcription initiation from RNA polymerase II promoter;GO:0060395,biological_process SMAD protein signal transduction;GO:0070062,cellular_component extracellular exosome	NA	SUB1 homolog%2C transcriptional regulator [Source:HGNC Symbol%3BAcc:HGNC:19985]
ENSG00000114767	13.48	12.61	15.44	13.35	13.31	15.54	-0.00731368249930509	4.32924004295958	0.957232092654698	0.999890155241779	3:51933429-51941941:-	RRP9	9;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031428,cellular_component box C/D snoRNP complex;GO:0032040,cellular_component small-subunit processome;GO:0034511,molecular_function U3 snoRNA binding	NA	ribosomal RNA processing 9%2C U3 small nucleolar RNA binding protein [Source:HGNC Symbol%3BAcc:HGNC:16829]
ENSG00000184937	2.49	2.32	2.54	2.49	2.57	2.43	-0.00918307020564713	2.0098333734279	0.957278224836325	0.999890155241779	11:32387774-32435630:-	WT1	66;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001570,biological_process vasculogenesis;GO:0001657,biological_process ureteric bud development;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001822,biological_process kidney development;GO:0003156,biological_process regulation of organ formation;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007281,biological_process germ cell development;GO:0007356,biological_process thorax and anterior abdomen determination;GO:0007507,biological_process heart development;GO:0007530,biological_process sex determination;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008380,biological_process RNA splicing;GO:0008406,biological_process gonad development;GO:0008584,biological_process male gonad development;GO:0009888,biological_process tissue development;GO:0010385,molecular_function double-stranded methylated DNA binding;GO:0016607,cellular_component nuclear speck;GO:0030308,biological_process negative regulation of cell growth;GO:0030325,biological_process adrenal gland development;GO:0030539,biological_process male genitalia development;GO:0030855,biological_process epithelial cell differentiation;GO:0032835,biological_process glomerulus development;GO:0032836,biological_process glomerular basement membrane development;GO:0035802,biological_process adrenal cortex formation;GO:0043010,biological_process camera-type eye development;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044729,molecular_function hemi-methylated DNA-binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060231,biological_process mesenchymal to epithelial transition;GO:0060421,biological_process positive regulation of heart growth;GO:0060539,biological_process diaphragm development;GO:0060923,biological_process cardiac muscle cell fate commitment;GO:0061032,biological_process visceral serous pericardium development;GO:0070742,molecular_function C2H2 zinc finger domain binding;GO:0071320,biological_process cellular response to cAMP;GO:0071371,biological_process cellular response to gonadotropin stimulus;GO:0072075,biological_process metanephric mesenchyme development;GO:0072112,biological_process glomerular visceral epithelial cell differentiation;GO:0072166,biological_process posterior mesonephric tubule development;GO:0072207,biological_process metanephric epithelium development;GO:0072284,biological_process metanephric S-shaped body morphogenesis;GO:0072302,biological_process negative regulation of metanephric glomerular mesangial cell proliferation;GO:2000020,biological_process positive regulation of male gonad development;GO:2000195,biological_process negative regulation of female gonad development;GO:2001076,biological_process positive regulation of metanephric ureteric bud development	WT1; Wilms tumor protein 1; K09234	Wilms tumor 1 [Source:HGNC Symbol%3BAcc:HGNC:12796]
ENSG00000101190	13.61	13.45	13.15	13.55	14.57	12.60	-0.00552983375029051	4.53961227305251	0.957404429732988	0.999893028590656	20:62841114-62861763:-	TCFL5	16;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001673,cellular_component male germ cell nucleus;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0042127,biological_process regulation of cell proliferation;GO:0045595,biological_process regulation of cell differentiation;GO:0046983,molecular_function protein dimerization activity	NA	transcription factor like 5 [Source:HGNC Symbol%3BAcc:HGNC:11646]
ENSG00000102904	1.48	1.55	1.55	1.28	1.83	1.57	-0.019356210354316	1.87729708578384	0.957442079902404	0.999893028590656	16:67806764-67832148:+	TSNAXIP1	8;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008150,biological_process biological_process;GO:0030154,biological_process cell differentiation;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	translin associated factor X interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:18586]
ENSG00000167566	11.97	11.25	12.29	11.68	11.70	12.35	0.00553367770123183	5.60388910679673	0.957614283730691	0.999970382248109	12:49791145-49828750:-	NCKAP5L	9;GO:0001578,biological_process microtubule bundle formation;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007019,biological_process microtubule depolymerization;GO:0035371,cellular_component microtubule plus-end	NA	NCK associated protein 5 like [Source:HGNC Symbol%3BAcc:HGNC:29321]
ENSG00000214050	3.24	2.38	2.86	2.85	2.95	2.90	-0.00713808217519935	1.94867498083197	0.957677266105335	0.999970382248109	8:28348286-28490318:-	FBXO16	NA	NA	F-box protein 16 [Source:HGNC Symbol%3BAcc:HGNC:13618]
ENSG00000162769	3.94	5.68	5.08	5.89	4.87	4.18	-0.0203346596425506	3.05808909473671	0.957768645933563	0.99998168071102	1:212858254-212899363:+	FLVCR1	27;GO:0001568,biological_process blood vessel development;GO:0001701,biological_process in utero embryonic development;GO:0005215,molecular_function transporter activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0007275,biological_process multicellular organism development;GO:0015232,molecular_function heme transporter activity;GO:0015886,biological_process heme transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030218,biological_process erythrocyte differentiation;GO:0031966,cellular_component mitochondrial membrane;GO:0035108,biological_process limb morphogenesis;GO:0035264,biological_process multicellular organism growth;GO:0042733,biological_process embryonic digit morphogenesis;GO:0043249,biological_process erythrocyte maturation;GO:0046620,biological_process regulation of organ growth;GO:0048536,biological_process spleen development;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0055085,biological_process transmembrane transport;GO:0060323,biological_process head morphogenesis;GO:0097037,biological_process heme export	NA	feline leukemia virus subgroup C cellular receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:24682]
ENSG00000134215	11.90	12.71	12.35	10.78	14.61	12.03	-0.00685322379916161	5.08989088783649	0.957945220650733	1	1:107571159-107965144:-	VAV3	40;GO:0001525,biological_process angiogenesis;GO:0005070,molecular_function SH3/SH2 adaptor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006906,biological_process vesicle fusion;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008361,biological_process regulation of cell size;GO:0009967,biological_process positive regulation of signal transduction;GO:0016477,biological_process cell migration;GO:0030031,biological_process cell projection assembly;GO:0030032,biological_process lamellipodium assembly;GO:0030168,biological_process platelet activation;GO:0030593,biological_process neutrophil chemotaxis;GO:0030676,molecular_function Rac guanyl-nucleotide exchange factor activity;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042493,biological_process response to drug;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045785,biological_process positive regulation of cell adhesion;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048013,biological_process ephrin receptor signaling pathway;GO:0050853,biological_process B cell receptor signaling pathway;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome	VAV; guanine nucleotide exchange factor VAV; K05730	vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol%3BAcc:HGNC:12659]
ENSG00000107560	5.97	5.75	6.69	5.16	5.94	7.31	0.012431815422318	3.31936969457391	0.958144499771024	1	10:118004915-118046603:-	RAB11FIP2	18;GO:0003091,biological_process renal water homeostasis;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005768,cellular_component endosome;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0017137,molecular_function Rab GTPase binding;GO:0019901,molecular_function protein kinase binding;GO:0030010,biological_process establishment of cell polarity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0035773,biological_process insulin secretion involved in cellular response to glucose stimulus;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045055,biological_process regulated exocytosis;GO:0055038,cellular_component recycling endosome membrane;GO:1903078,biological_process positive regulation of protein localization to plasma membrane	RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5; K12484	RAB11 family interacting protein 2 [Source:HGNC Symbol%3BAcc:HGNC:29152]
ENSG00000182405	2.01	2.29	2.26	1.96	2.12	2.44	0.0112956194603636	1.99201354588505	0.9582239609237	1	15:34102072-34108684:+	PGBD4	NA	NA	piggyBac transposable element derived 4 [Source:HGNC Symbol%3BAcc:HGNC:19401]
ENSG00000100982	19.19	20.18	19.83	18.57	20.40	20.87	-0.00581046351790655	5.45146174035789	0.958556292198752	1	20:45934627-45948023:+	PCIF1	5;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0010923,biological_process negative regulation of phosphatase activity;GO:0015630,cellular_component microtubule cytoskeleton;GO:0045171,cellular_component intercellular bridge	NA	PDX1 C-terminal inhibiting factor 1 [Source:HGNC Symbol%3BAcc:HGNC:16200]
ENSG00000163930	38.40	42.24	36.77	39.32	40.16	39.13	-0.00503522435330773	6.75508811923224	0.958726457482564	1	3:52401012-52410350:-	BAP1	29;GO:0001558,biological_process regulation of cell growth;GO:0003682,molecular_function chromatin binding;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010035,biological_process response to inorganic substance;GO:0016569,biological_process covalent chromatin modification;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0035517,cellular_component PR-DUB complex;GO:0035520,biological_process monoubiquitinated protein deubiquitination;GO:0035522,biological_process monoubiquitinated histone H2A deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0050727,biological_process regulation of inflammatory response;GO:0051726,biological_process regulation of cell cycle;GO:0061519,biological_process macrophage homeostasis;GO:0071108,biological_process protein K48-linked deubiquitination;GO:1900015,biological_process regulation of cytokine production involved in inflammatory response;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	NA	BRCA1 associated protein 1 [Source:HGNC Symbol%3BAcc:HGNC:950]
ENSG00000178401	26.92	25.41	25.25	28.69	25.50	24.40	-0.00456384082058848	4.74434096788452	0.958965804152709	1	12:49346916-49357546:+	DNAJC22	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	DnaJ heat shock protein family (Hsp40) member C22 [Source:HGNC Symbol%3BAcc:HGNC:25802]
ENSG00000158882	4.66	3.83	3.03	4.05	3.69	3.73	0.0206349626206788	1.88681225038279	0.959097294945452	1	1:161225938-161230744:+	TOMM40L	16;GO:0003674,molecular_function molecular_function;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005742,cellular_component mitochondrial outer membrane translocase complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0008150,biological_process biological_process;GO:0015031,biological_process protein transport;GO:0015266,molecular_function protein channel activity;GO:0015288,molecular_function porin activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030150,biological_process protein import into mitochondrial matrix;GO:0043234,cellular_component protein complex;GO:0046930,cellular_component pore complex;GO:0055085,biological_process transmembrane transport	TOM40; mitochondrial import receptor subunit TOM40; K11518	translocase of outer mitochondrial membrane 40 like [Source:HGNC Symbol%3BAcc:HGNC:25756]
ENSG00000133030	18.25	16.26	18.26	18.62	17.31	17.42	-0.00285557588547837	7.07069304882857	0.95910976661825	1	17:17042544-17217679:+	MPRIP	8;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0015629,cellular_component actin cytoskeleton;GO:0045296,molecular_function cadherin binding	NA	myosin phosphatase Rho interacting protein [Source:HGNC Symbol%3BAcc:HGNC:30321]
ENSG00000134597	17.06	23.28	18.91	20.47	18.94	19.80	0.00124066569558725	4.26908244374044	0.959212279634777	1	X:130401968-130413343:+	RBMX2	10;GO:0000384,molecular_function first spliceosomal transesterification activity;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005686,cellular_component U2 snRNP;GO:0006406,biological_process mRNA export from nucleus;GO:0070274,cellular_component RES complex;GO:0071011,cellular_component precatalytic spliceosome;GO:0071013,cellular_component catalytic step 2 spliceosome	NA	RNA binding motif protein%2C X-linked 2 [Source:HGNC Symbol%3BAcc:HGNC:24282]
ENSG00000151729	8.21	11.84	8.96	9.44	11.13	8.25	0.00904270727580537	3.16106942374989	0.959276808851438	1	4:185143240-185150382:+	SLC25A4	23;GO:0000002,biological_process mitochondrial genome maintenance;GO:0005215,molecular_function transporter activity;GO:0005471,molecular_function ATP:ADP antiporter activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006810,biological_process transport;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0015207,molecular_function adenine transmembrane transporter activity;GO:0015853,biological_process adenine transport;GO:0015866,biological_process ADP transport;GO:0015867,biological_process ATP transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0043209,cellular_component myelin sheath;GO:0046902,biological_process regulation of mitochondrial membrane permeability;GO:0050796,biological_process regulation of insulin secretion;GO:0055085,biological_process transmembrane transport;GO:0060546,biological_process negative regulation of necroptotic process	SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31; K05863	solute carrier family 25 member 4 [Source:HGNC Symbol%3BAcc:HGNC:10990]
ENSG00000119684	12.16	11.40	12.06	12.37	10.99	12.68	-0.00381440974744608	5.73582915244922	0.959277191784096	1	14:75013763-75051532:-	MLH3	23;GO:0000793,cellular_component condensed chromosome;GO:0000794,cellular_component condensed nuclear chromosome;GO:0000795,cellular_component synaptonemal complex;GO:0001673,cellular_component male germ cell nucleus;GO:0003682,molecular_function chromatin binding;GO:0003696,molecular_function satellite DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005712,cellular_component chiasma;GO:0006281,biological_process DNA repair;GO:0006298,biological_process mismatch repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007130,biological_process synaptonemal complex assembly;GO:0007131,biological_process reciprocal meiotic recombination;GO:0007140,biological_process male meiosis;GO:0007144,biological_process female meiosis I;GO:0008104,biological_process protein localization;GO:0016887,molecular_function ATPase activity;GO:0019237,molecular_function centromeric DNA binding;GO:0030983,molecular_function mismatched DNA binding;GO:0032300,cellular_component mismatch repair complex	MLH3; DNA mismatch repair protein MLH3; K08739	mutL homolog 3 [Source:HGNC Symbol%3BAcc:HGNC:7128]
ENSG00000188596	0.31	0.34	0.44	0.33	0.37	0.42	-0.0185304292758337	1.88655202378743	0.959341655133756	1	12:96489570-96875555:+	CFAP54	12;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030030,biological_process cell projection organization;GO:0030154,biological_process cell differentiation;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0060294,biological_process cilium movement involved in cell motility	NA	cilia and flagella associated protein 54 [Source:HGNC Symbol%3BAcc:HGNC:26456]
ENSG00000100726	11.76	10.31	11.52	11.72	12.02	10.05	0.00928165423374489	4.82792407084815	0.959530968733232	1	16:1493343-1510457:+	TELO2	21;GO:0000781,cellular_component chromosome, telomeric region;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016604,cellular_component nuclear body;GO:0019901,molecular_function protein kinase binding;GO:0031931,cellular_component TORC1 complex;GO:0031932,cellular_component TORC2 complex;GO:0032006,biological_process regulation of TOR signaling;GO:0032403,molecular_function protein complex binding;GO:0032947,molecular_function protein complex scaffold;GO:0034399,cellular_component nuclear periphery;GO:0050821,biological_process protein stabilization;GO:0051879,molecular_function Hsp90 protein binding;GO:0071902,biological_process positive regulation of protein serine/threonine kinase activity;GO:1904263,biological_process positive regulation of TORC1 signaling;GO:1904515,biological_process positive regulation of TORC2 signaling	TELO2, TEL2; telomere length regulation protein; K11137	telomere maintenance 2 [Source:HGNC Symbol%3BAcc:HGNC:29099]
ENSG00000111911	28.20	26.43	27.36	26.74	26.95	29.36	-0.00484471945838866	3.92607334108446	0.960008090569832	1	6:125956780-125980244:+	HINT3	6;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0016787,molecular_function hydrolase activity;GO:0070062,cellular_component extracellular exosome	NA	histidine triad nucleotide binding protein 3 [Source:HGNC Symbol%3BAcc:HGNC:18468]
ENSG00000185379	2.69	3.21	2.98	2.63	2.66	3.54	0.00540659110321153	2.00576747589562	0.960240483632722	1	17:35092207-35121522:-	RAD51D	38;GO:0000150,molecular_function recombinase activity;GO:0000166,molecular_function nucleotide binding;GO:0000400,molecular_function four-way junction DNA binding;GO:0000707,biological_process meiotic DNA recombinase assembly;GO:0000723,biological_process telomere maintenance;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0004520,molecular_function endodeoxyribonuclease activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005657,cellular_component replication fork;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006310,biological_process DNA recombination;GO:0006312,biological_process mitotic recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007131,biological_process reciprocal meiotic recombination;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0010212,biological_process response to ionizing radiation;GO:0033063,cellular_component Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0036297,biological_process interstrand cross-link repair;GO:0042148,biological_process strand invasion;GO:0043015,molecular_function gamma-tubulin binding;GO:0051276,biological_process chromosome organization;GO:0051726,biological_process regulation of cell cycle	RAD51L3, RAD51D; RAD51-like protein 3; K10871	RAD51 paralog D [Source:HGNC Symbol%3BAcc:HGNC:9823]
ENSG00000181830	11.96	13.65	12.60	12.07	13.68	12.43	0.00720422363925264	3.81032890077471	0.960274007848092	1	11:45804071-45813015:+	SLC35C1	10;GO:0000139,cellular_component Golgi membrane;GO:0005457,molecular_function GDP-fucose transmembrane transporter activity;GO:0005794,cellular_component Golgi apparatus;GO:0006810,biological_process transport;GO:0008643,biological_process carbohydrate transport;GO:0015783,biological_process GDP-fucose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030259,biological_process lipid glycosylation;GO:0045746,biological_process negative regulation of Notch signaling pathway	NA	solute carrier family 35 member C1 [Source:HGNC Symbol%3BAcc:HGNC:20197]
ENSG00000165275	13.93	11.86	13.83	13.31	13.34	13.22	0.0121595259895577	3.85890944776654	0.96028100373468	1	9:37753802-37778972:+	TRMT10B	6;GO:0005829,cellular_component cytosol;GO:0008168,molecular_function methyltransferase activity;GO:0009019,molecular_function tRNA (guanine-N1-)-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0032259,biological_process methylation	NA	tRNA methyltransferase 10B [Source:HGNC Symbol%3BAcc:HGNC:26454]
ENSG00000173917	24.27	20.58	24.67	23.49	23.65	23.44	-0.00171899698199867	4.65343520515375	0.960554937596841	1	17:48540893-48544989:-	HOXB2	23;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0008015,biological_process blood circulation;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0016607,cellular_component nuclear speck;GO:0021569,biological_process rhombomere 3 development;GO:0021570,biological_process rhombomere 4 development;GO:0021612,biological_process facial nerve structural organization;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048705,biological_process skeletal system morphogenesis;GO:0048857,biological_process neural nucleus development	NA	homeobox B2 [Source:HGNC Symbol%3BAcc:HGNC:5113]
ENSG00000172339	17.33	18.29	12.61	17.10	15.45	15.63	0.00532800545441776	3.39620651151686	0.960635445580277	1	1:94974406-95072945:-	ALG14	8;GO:0004577,molecular_function N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity;GO:0005634,cellular_component nucleus;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane	ALG14; beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.141]; K07441	ALG14%2C UDP-N-acetylglucosaminyltransferase subunit [Source:HGNC Symbol%3BAcc:HGNC:28287]
ENSG00000169118	6.87	7.81	7.85	7.83	7.50	7.21	0.00744827460926256	3.86494184255368	0.960847424531296	1	15:64165516-64356259:-	CSNK1G1	18;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation	CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]; K08958	casein kinase 1 gamma 1 [Source:HGNC Symbol%3BAcc:HGNC:2454]
ENSG00000090266	136.33	151.80	122.17	131.28	146.91	133.82	0.00308220271941322	6.3342934170065	0.961196276377185	1	7:140690776-140722790:+	NDUFB2	9;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0016020,cellular_component membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2; K03958	NADH:ubiquinone oxidoreductase subunit B2 [Source:HGNC Symbol%3BAcc:HGNC:7697]
ENSG00000055130	47.54	49.47	50.24	50.20	50.43	48.15	-0.00349851269347077	6.84637390110765	0.961394270279391	1	7:148697913-148801036:+	CUL1	36;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006513,biological_process protein monoubiquitination;GO:0006879,biological_process cellular iron ion homeostasis;GO:0006915,biological_process apoptotic process;GO:0007050,biological_process cell cycle arrest;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009887,biological_process organ morphogenesis;GO:0010265,biological_process SCF complex assembly;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016032,biological_process viral process;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0019005,cellular_component SCF ubiquitin ligase complex;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031461,cellular_component cullin-RING ubiquitin ligase complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043687,biological_process post-translational protein modification;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051403,biological_process stress-activated MAPK cascade;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0097193,biological_process intrinsic apoptotic signaling pathway;GO:1990452,cellular_component Parkin-FBXW7-Cul1 ubiquitin ligase complex	CUL1, CDC53; cullin 1; K03347	cullin 1 [Source:HGNC Symbol%3BAcc:HGNC:2551]
ENSG00000197586	39.23	39.85	39.17	39.02	42.26	38.24	-0.00381824710184541	6.01987448640873	0.961478166870637	1	20:25195692-25226729:+	ENTPD6	17;GO:0000139,cellular_component Golgi membrane;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0008894,molecular_function guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0017110,molecular_function nucleoside-diphosphatase activity;GO:0017111,molecular_function nucleoside-triphosphatase activity;GO:0032026,biological_process response to magnesium ion;GO:0034656,biological_process nucleobase-containing small molecule catabolic process;GO:0045134,molecular_function uridine-diphosphatase activity;GO:0051592,biological_process response to calcium ion;GO:0070062,cellular_component extracellular exosome	ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6]; K01511	ectonucleoside triphosphate diphosphohydrolase 6 (putative) [Source:HGNC Symbol%3BAcc:HGNC:3368]
ENSG00000144895	60.78	59.66	61.16	60.47	59.89	62.34	0.00335669318527445	6.84313945042362	0.961729023885412	1	3:150546677-150584242:+	EIF2A	19;GO:0000049,molecular_function tRNA binding;GO:0003729,molecular_function mRNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005850,cellular_component eukaryotic translation initiation factor 2 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006417,biological_process regulation of translation;GO:0006468,biological_process protein phosphorylation;GO:0009967,biological_process positive regulation of signal transduction;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0032933,biological_process SREBP signaling pathway;GO:0042255,biological_process ribosome assembly;GO:0043022,molecular_function ribosome binding;GO:0045296,molecular_function cadherin binding;GO:0072562,cellular_component blood microparticle;GO:1990928,biological_process response to amino acid starvation	NA	eukaryotic translation initiation factor 2A [Source:HGNC Symbol%3BAcc:HGNC:3254]
ENSG00000111669	1266.66	1355.85	1296.34	1302.75	1364.02	1276.05	0.00286242009731435	10.1358893524557	0.96189353360412	1	12:6867118-6870948:+	TPI1	19;GO:0003824,molecular_function catalytic activity;GO:0004807,molecular_function triose-phosphate isomerase activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006006,biological_process glucose metabolic process;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0006098,biological_process pentose-phosphate shunt;GO:0007275,biological_process multicellular organism development;GO:0008152,biological_process metabolic process;GO:0016853,molecular_function isomerase activity;GO:0019563,biological_process glycerol catabolic process;GO:0019682,biological_process glyceraldehyde-3-phosphate metabolic process;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0046166,biological_process glyceraldehyde-3-phosphate biosynthetic process;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome	TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]; K01803	triosephosphate isomerase 1 [Source:HGNC Symbol%3BAcc:HGNC:12009]
ENSG00000068885	5.77	6.46	5.52	5.50	6.13	6.32	-0.012656502111229	3.86365251622598	0.961965573596729	1	3:160256985-160399880:-	IFT80	9;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0030992,cellular_component intraciliary transport particle B;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097542,cellular_component ciliary tip	NA	intraflagellar transport 80 [Source:HGNC Symbol%3BAcc:HGNC:29262]
ENSG00000174808	9.39	8.59	8.96	8.69	9.09	9.61	-0.008670543216153	2.32234205662543	0.961991306835079	1	4:74744758-74794686:-	BTC	30;GO:0000165,biological_process MAPK cascade;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0035810,biological_process positive regulation of urine volume;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0051781,biological_process positive regulation of cell division;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:2000145,biological_process regulation of cell motility	BTC; betacellulin; K09783	betacellulin [Source:HGNC Symbol%3BAcc:HGNC:1121]
ENSG00000272325	4.93	6.30	7.85	8.27	5.44	5.72	-0.0162019426043856	1.79046582283853	0.962044573809714	1	6:34279678-34392674:-	NUDT3	28;GO:0000287,molecular_function magnesium ion binding;GO:0000298,molecular_function endopolyphosphatase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007267,biological_process cell-cell signaling;GO:0008486,molecular_function diphosphoinositol-polyphosphate diphosphatase activity;GO:0015961,biological_process diadenosine polyphosphate catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0034431,molecular_function bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432,molecular_function bis(5'-adenosyl)-pentaphosphatase activity;GO:0043647,biological_process inositol phosphate metabolic process;GO:0046872,molecular_function metal ion binding;GO:0050072,molecular_function m7G(5')pppN diphosphatase activity;GO:0052840,molecular_function inositol diphosphate tetrakisphosphate diphosphatase activity;GO:0052841,molecular_function inositol bisdiphosphate tetrakisphosphate diphosphatase activity;GO:0052842,molecular_function inositol diphosphate pentakisphosphate diphosphatase activity;GO:0052843,molecular_function inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity;GO:0052844,molecular_function inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity;GO:0052845,molecular_function inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity;GO:0052846,molecular_function inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity;GO:0052847,molecular_function inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0052848,molecular_function inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0070062,cellular_component extracellular exosome;GO:0071544,biological_process diphosphoinositol polyphosphate catabolic process;GO:1901907,biological_process diadenosine pentaphosphate catabolic process;GO:1901909,biological_process diadenosine hexaphosphate catabolic process;GO:1901911,biological_process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	RP-S10e, RPS10; small subunit ribosomal protein S10e; K02947	nudix hydrolase 3 [Source:HGNC Symbol%3BAcc:HGNC:8050]
ENSG00000121900	135.21	138.90	136.04	134.45	138.13	141.80	-0.00392483123077914	6.51918450645854	0.962052232502719	1	1:32894593-32901438:-	TMEM54	5;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 54 [Source:HGNC Symbol%3BAcc:HGNC:24143]
ENSG00000167785	20.56	17.83	23.62	20.92	19.43	22.56	-0.00349939457597268	4.66448592758328	0.962228624116907	1	19:8806169-8832328:-	ZNF558	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008150,biological_process biological_process;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 558 [Source:HGNC Symbol%3BAcc:HGNC:26422]
ENSG00000104885	4.67	4.94	5.17	5.04	4.77	5.14	-0.00611531209004402	4.76544214823658	0.962441338396888	1	19:2164148-2232578:+	DOT1L	25;GO:0000077,biological_process DNA damage checkpoint;GO:0000781,cellular_component chromosome, telomeric region;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006281,biological_process DNA repair;GO:0006342,biological_process chromatin silencing;GO:0006348,biological_process chromatin silencing at telomere;GO:0008168,molecular_function methyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0031151,molecular_function histone methyltransferase activity (H3-K79 specific);GO:0032200,biological_process telomere organization;GO:0032259,biological_process methylation;GO:0034729,biological_process histone H3-K79 methylation;GO:0042054,molecular_function histone methyltransferase activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046425,biological_process regulation of JAK-STAT cascade;GO:0051726,biological_process regulation of cell cycle;GO:2000677,biological_process regulation of transcription regulatory region DNA binding	DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]; K11427	DOT1 like histone lysine methyltransferase [Source:HGNC Symbol%3BAcc:HGNC:24948]
ENSG00000214717	9.60	11.98	10.50	10.25	11.91	9.96	0.00328241601327528	4.48307669805738	0.9624456930787	1	X:2486413-2500967:-	ZBED1	23;GO:0000228,cellular_component nuclear chromosome;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004803,molecular_function transposase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0016925,biological_process protein sumoylation;GO:0019789,molecular_function SUMO transferase activity;GO:0031965,cellular_component nuclear membrane;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity	NA	zinc finger BED-type containing 1 [Source:HGNC Symbol%3BAcc:HGNC:447]
ENSG00000018610	23.65	21.95	25.53	23.95	24.94	23.33	-0.00328887476117465	4.00897006141925	0.96257871787664	1	X:119538148-119565408:-	CXorf56	NA	NA	chromosome X open reading frame 56 [Source:HGNC Symbol%3BAcc:HGNC:26239]
ENSG00000100311	19.92	17.41	21.06	20.41	18.12	20.78	-0.00371639528759404	3.88210953370742	0.962767147137991	1	22:39223358-39244751:-	PDGFB	94;GO:0000139,cellular_component Golgi membrane;GO:0000165,biological_process MAPK cascade;GO:0001892,biological_process embryonic placenta development;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002548,biological_process monocyte chemotaxis;GO:0002576,biological_process platelet degranulation;GO:0003104,biological_process positive regulation of glomerular filtration;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005161,molecular_function platelet-derived growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005796,cellular_component Golgi lumen;GO:0006468,biological_process protein phosphorylation;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0008083,molecular_function growth factor activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009611,biological_process response to wounding;GO:0009986,cellular_component cell surface;GO:0010512,biological_process negative regulation of phosphatidylinositol biosynthetic process;GO:0010544,biological_process negative regulation of platelet activation;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014911,biological_process positive regulation of smooth muscle cell migration;GO:0016020,cellular_component membrane;GO:0016176,molecular_function superoxide-generating NADPH oxidase activator activity;GO:0016323,cellular_component basolateral plasma membrane;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0031012,cellular_component extracellular matrix;GO:0031093,cellular_component platelet alpha granule lumen;GO:0031954,biological_process positive regulation of protein autophosphorylation;GO:0032091,biological_process negative regulation of protein binding;GO:0032147,biological_process activation of protein kinase activity;GO:0032148,biological_process activation of protein kinase B activity;GO:0035655,biological_process interleukin-18-mediated signaling pathway;GO:0035793,biological_process positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0038001,biological_process paracrine signaling;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0042056,molecular_function chemoattractant activity;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043536,biological_process positive regulation of blood vessel endothelial cell migration;GO:0043547,biological_process positive regulation of GTPase activity;GO:0043552,biological_process positive regulation of phosphatidylinositol 3-kinase activity;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045740,biological_process positive regulation of DNA replication;GO:0045840,biological_process positive regulation of mitotic nuclear division;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048146,biological_process positive regulation of fibroblast proliferation;GO:0048407,molecular_function platelet-derived growth factor binding;GO:0048661,biological_process positive regulation of smooth muscle cell proliferation;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050918,biological_process positive chemotaxis;GO:0050921,biological_process positive regulation of chemotaxis;GO:0051781,biological_process positive regulation of cell division;GO:0060326,biological_process cell chemotaxis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070528,biological_process protein kinase C signaling;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071506,biological_process cellular response to mycophenolic acid;GO:0072126,biological_process positive regulation of glomerular mesangial cell proliferation;GO:0072255,biological_process metanephric glomerular mesangial cell development;GO:0072593,biological_process reactive oxygen species metabolic process;GO:0090280,biological_process positive regulation of calcium ion import;GO:1900127,biological_process positive regulation of hyaluronan biosynthetic process;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1904707,biological_process positive regulation of vascular smooth muscle cell proliferation;GO:1904754,biological_process positive regulation of vascular associated smooth muscle cell migration;GO:1905064,biological_process negative regulation of vascular smooth muscle cell differentiation;GO:1905176,biological_process positive regulation of vascular smooth muscle cell dedifferentiation;GO:2000379,biological_process positive regulation of reactive oxygen species metabolic process;GO:2000573,biological_process positive regulation of DNA biosynthetic process;GO:2000587,biological_process negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:2000591,biological_process positive regulation of metanephric mesenchymal cell migration	PDGFB; platelet-derived growth factor subunit B; K17386	platelet derived growth factor subunit B [Source:HGNC Symbol%3BAcc:HGNC:8800]
ENSG00000183647	2.44	2.36	2.43	2.92	2.33	2.12	-0.0122993084168698	2.19727853345752	0.962815070922471	1	19:57599884-57612722:+	ZNF530	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 530 [Source:HGNC Symbol%3BAcc:HGNC:29297]
ENSG00000179833	24.22	25.36	24.14	26.86	22.30	25.38	-0.00745365124310507	4.55039997805328	0.962836799608925	1	2:64631620-64751005:-	SERTAD2	9;GO:0003713,molecular_function transcription coactivator activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030308,biological_process negative regulation of cell growth;GO:0045893,biological_process positive regulation of transcription, DNA-templated	NA	SERTA domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:30784]
ENSG00000176994	11.31	10.71	10.76	10.76	12.25	10.18	-0.00371156172416041	4.95784386109751	0.962847793872933	1	17:18315309-18328055:+	SMCR8	23;GO:0000785,cellular_component chromatin;GO:0004860,molecular_function protein kinase inhibitor activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006469,biological_process negative regulation of protein kinase activity;GO:0006914,biological_process autophagy;GO:0010506,biological_process regulation of autophagy;GO:0010629,biological_process negative regulation of gene expression;GO:0016242,biological_process negative regulation of macroautophagy;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0019901,molecular_function protein kinase binding;GO:0032008,biological_process positive regulation of TOR signaling;GO:0032045,cellular_component guanyl-nucleotide exchange factor complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:1901098,biological_process positive regulation of autophagosome maturation;GO:1902902,biological_process negative regulation of autophagosome assembly;GO:1903432,biological_process regulation of TORC1 signaling;GO:1990316,cellular_component ATG1/ULK1 kinase complex	NA	Smith-Magenis syndrome chromosome region%2C candidate 8 [Source:HGNC Symbol%3BAcc:HGNC:17921]
ENSG00000168827	18.61	22.19	19.55	18.70	21.09	21.15	-0.00734874870340236	5.56338384452546	0.962923610733478	1	3:158644277-158692575:+	GFM1	12;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0003746,molecular_function translation elongation factor activity;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006412,biological_process translation;GO:0006414,biological_process translational elongation;GO:0070125,biological_process mitochondrial translational elongation	NA	G elongation factor mitochondrial 1 [Source:HGNC Symbol%3BAcc:HGNC:13780]
ENSG00000182809	100.22	81.91	102.24	96.42	86.03	105.40	-0.00347386710708185	6.48871165893025	0.962996868640241	1	14:105472961-105480170:+	CRIP2	6;GO:0005938,cellular_component cell cortex;GO:0008270,molecular_function zinc ion binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0030097,biological_process hemopoiesis;GO:0031012,cellular_component extracellular matrix;GO:0046872,molecular_function metal ion binding	NA	cysteine rich protein 2 [Source:HGNC Symbol%3BAcc:HGNC:2361]
ENSG00000126773	32.14	31.53	33.74	31.73	32.33	33.95	0.0034940628985308	6.86745653006965	0.963048057534659	1	14:60091910-60169133:+	PCNX4	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	pecanex homolog 4 [Source:HGNC Symbol%3BAcc:HGNC:20349]
ENSG00000164244	34.19	37.37	33.92	35.62	34.46	36.41	-0.00589653744641711	5.77603694066964	0.963195659503893	1	5:127517608-127555089:+	PRRC1	2;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus	NA	proline rich coiled-coil 1 [Source:HGNC Symbol%3BAcc:HGNC:28164]
ENSG00000125459	7.41	5.52	5.49	7.20	6.10	5.41	-0.00277111795030319	3.43384167484545	0.96363573028008	1	1:155610204-155614967:+	MSTO1	8;GO:0003674,molecular_function molecular_function;GO:0003924,molecular_function GTPase activity;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0007005,biological_process mitochondrion organization;GO:0016020,cellular_component membrane;GO:0048311,biological_process mitochondrion distribution	NA	misato 1%2C mitochondrial distribution and morphology regulator [Source:HGNC Symbol%3BAcc:HGNC:29678]
ENSG00000172375	2.14	2.32	1.89	1.71	2.30	2.30	0.0109705271704491	2.22133373145395	0.963729416028056	1	11:119102197-119118544:+	C2CD2L	16;GO:0005548,molecular_function phospholipid transporter activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0008289,molecular_function lipid binding;GO:0008526,molecular_function phosphatidylinositol transporter activity;GO:0015914,biological_process phospholipid transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032541,cellular_component cortical endoplasmic reticulum;GO:0035091,molecular_function phosphatidylinositol binding;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0043559,molecular_function insulin binding;GO:0098592,cellular_component cytoplasmic side of apical plasma membrane	NA	C2CD2 like [Source:HGNC Symbol%3BAcc:HGNC:29000]
ENSG00000078403	14.03	13.07	14.34	14.50	13.80	13.41	0.00561988872743997	5.66879405391181	0.963811597385057	1	10:21524674-21743630:+	MLLT10	11;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043234,cellular_component protein complex;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	MLLT10%2C histone lysine methyltransferase DOT1L cofactor [Source:HGNC Symbol%3BAcc:HGNC:16063]
ENSG00000101216	6.88	8.53	8.24	8.29	8.82	6.85	-0.0112781397879337	3.67029854342265	0.963992492415141	1	20:63587601-63627041:-	GMEB2	14;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	glucocorticoid modulatory element binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:4371]
ENSG00000188352	11.03	10.79	11.64	11.25	11.30	11.12	0.00431470073004375	5.93871794441429	0.964047668782848	1	9:20658308-20995955:+	FOCAD	5;GO:0005515,molecular_function protein binding;GO:0005925,cellular_component focal adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction	NA	focadhesin [Source:HGNC Symbol%3BAcc:HGNC:23377]
ENSG00000213337	9.39	7.83	6.17	8.46	7.05	7.81	0.0182033105421511	2.14812050089517	0.964128181044148	1	2:96836610-96858095:-	ANKRD39	3;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process	NA	ankyrin repeat domain 39 [Source:HGNC Symbol%3BAcc:HGNC:28640]
ENSG00000204519	2.16	2.59	2.11	2.11	2.02	2.67	0.00769999087799552	2.24861263445345	0.964265082794855	1	19:57681968-57717301:+	ZNF551	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 551 [Source:HGNC Symbol%3BAcc:HGNC:25108]
ENSG00000047579	13.94	14.53	14.41	14.78	13.98	14.31	0.00358820686522827	4.23313736923844	0.964539790625617	1	6:15522800-15663058:-	DTNBP1	46;GO:0001956,biological_process positive regulation of neurotransmitter secretion;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006996,biological_process organelle organization;GO:0007596,biological_process blood coagulation;GO:0008089,biological_process anterograde axonal transport;GO:0010008,cellular_component endosome membrane;GO:0010628,biological_process positive regulation of gene expression;GO:0014059,biological_process regulation of dopamine secretion;GO:0014069,cellular_component postsynaptic density;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016528,cellular_component sarcoplasm;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0030426,cellular_component growth cone;GO:0030496,cellular_component midbody;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031083,cellular_component BLOC-1 complex;GO:0031175,biological_process neuron projection development;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0032091,biological_process negative regulation of protein binding;GO:0032438,biological_process melanosome organization;GO:0033162,cellular_component melanosome membrane;GO:0042383,cellular_component sarcolemma;GO:0043005,cellular_component neuron projection;GO:0043197,cellular_component dendritic spine;GO:0043506,biological_process regulation of JUN kinase activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048490,biological_process anterograde synaptic vesicle transport;GO:0048812,biological_process neuron projection morphogenesis;GO:0048813,biological_process dendrite morphogenesis;GO:0050896,biological_process response to stimulus;GO:0060155,biological_process platelet dense granule organization;GO:0060159,biological_process regulation of dopamine receptor signaling pathway;GO:0071901,biological_process negative regulation of protein serine/threonine kinase activity;GO:1904115,cellular_component axon cytoplasm	NA	dystrobrevin binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17328]
ENSG00000162694	12.54	15.36	13.65	12.26	15.03	14.70	-0.0127904085149424	3.8312883672901	0.964577106535352	1	1:100872371-100895998:-	EXTL2	18;GO:0001888,molecular_function glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0005539,molecular_function glycosaminoglycan binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0015012,biological_process heparan sulfate proteoglycan biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0019276,biological_process UDP-N-acetylgalactosamine metabolic process;GO:0030145,molecular_function manganese ion binding;GO:0035248,molecular_function alpha-1,4-N-acetylgalactosaminyltransferase activity;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0046872,molecular_function metal ion binding;GO:0047237,molecular_function glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0070062,cellular_component extracellular exosome	EXTL2; alpha-1,4-N-acetylglucosaminyltransferase EXTL2 [EC:2.4.1.223]; K02369	exostosin like glycosyltransferase 2 [Source:HGNC Symbol%3BAcc:HGNC:3516]
ENSG00000058453	4.93	4.62	5.29	4.83	4.68	5.41	0.00612442588684474	4.91977680484019	0.964698602884493	1	1:16740272-16972979:+	CROCC	29;GO:0001917,cellular_component photoreceptor inner segment;GO:0003779,molecular_function actin binding;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0008104,biological_process protein localization;GO:0010457,biological_process centriole-centriole cohesion;GO:0010669,biological_process epithelial structure maintenance;GO:0015629,cellular_component actin cytoskeleton;GO:0019894,molecular_function kinesin binding;GO:0030030,biological_process cell projection organization;GO:0032053,biological_process ciliary basal body organization;GO:0033365,biological_process protein localization to organelle;GO:0035253,cellular_component ciliary rootlet;GO:0042995,cellular_component cell projection;GO:0045494,biological_process photoreceptor cell maintenance;GO:0045724,biological_process positive regulation of cilium assembly;GO:0051656,biological_process establishment of organelle localization;GO:0070062,cellular_component extracellular exosome;GO:1903566,biological_process positive regulation of protein localization to cilium	NA	ciliary rootlet coiled-coil%2C rootletin [Source:HGNC Symbol%3BAcc:HGNC:21299]
ENSG00000138639	5.65	6.60	5.11	5.23	6.39	5.92	-0.0125103130264515	3.79928172422269	0.964990838907734	1	4:85475113-86002670:+	ARHGAP24	15;GO:0001525,biological_process angiogenesis;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005912,cellular_component adherens junction;GO:0005925,cellular_component focal adhesion;GO:0007165,biological_process signal transduction;GO:0007275,biological_process multicellular organism development;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0042995,cellular_component cell projection;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 24 [Source:HGNC Symbol%3BAcc:HGNC:25361]
ENSG00000073969	8.44	8.34	8.20	8.59	8.41	8.28	-0.00598045950616903	4.29639169791543	0.965123278335056	1	17:46590668-46757464:+	NSF	39;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0000166,molecular_function nucleotide binding;GO:0001921,biological_process positive regulation of receptor recycling;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005795,cellular_component Golgi stack;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006813,biological_process potassium ion transport;GO:0006886,biological_process intracellular protein transport;GO:0006887,biological_process exocytosis;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016192,biological_process vesicle-mediated transport;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0017075,molecular_function syntaxin-1 binding;GO:0017137,molecular_function Rab GTPase binding;GO:0017157,biological_process regulation of exocytosis;GO:0019901,molecular_function protein kinase binding;GO:0019905,molecular_function syntaxin binding;GO:0030165,molecular_function PDZ domain binding;GO:0032403,molecular_function protein complex binding;GO:0035255,molecular_function ionotropic glutamate receptor binding;GO:0035494,biological_process SNARE complex disassembly;GO:0042623,molecular_function ATPase activity, coupled;GO:0043198,cellular_component dendritic shaft;GO:0043209,cellular_component myelin sheath;GO:0045026,biological_process plasma membrane fusion;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0048208,biological_process COPII vesicle coating;GO:0070062,cellular_component extracellular exosome	NSF, SEC18; vesicle-fusing ATPase [EC:3.6.4.6]; K06027	N-ethylmaleimide sensitive factor%2C vesicle fusing ATPase [Source:HGNC Symbol%3BAcc:HGNC:8016]
ENSG00000115307	80.95	76.48	82.80	78.70	76.50	87.68	-0.00311194354693177	6.68212171501991	0.965202777977732	1	2:74526644-74529939:-	AUP1	13;GO:0000839,cellular_component Hrd1p ubiquitin ligase ERAD-L complex;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0030970,biological_process retrograde protein transport, ER to cytosol;GO:0043130,molecular_function ubiquitin binding;GO:0050790,biological_process regulation of catalytic activity;GO:0070062,cellular_component extracellular exosome;GO:0097027,molecular_function ubiquitin-protein transferase activator activity	NA	ancient ubiquitous protein 1 [Source:HGNC Symbol%3BAcc:HGNC:891]
ENSG00000166949	29.02	26.46	25.08	27.56	26.27	27.19	0.00472875537799796	5.44566265841055	0.965206173840234	1	15:67063762-67195195:+	SMAD3	136;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000983,molecular_function transcription factor activity, RNA polymerase II core promoter sequence-specific;GO:0000987,molecular_function core promoter proximal region sequence-specific DNA binding;GO:0000988,molecular_function transcription factor activity, protein binding;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0001501,biological_process skeletal system development;GO:0001649,biological_process osteoblast differentiation;GO:0001657,biological_process ureteric bud development;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001707,biological_process mesoderm formation;GO:0001756,biological_process somitogenesis;GO:0001889,biological_process liver development;GO:0001947,biological_process heart looping;GO:0002076,biological_process osteoblast development;GO:0002520,biological_process immune system development;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003690,molecular_function double-stranded DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006955,biological_process immune response;GO:0007050,biological_process cell cycle arrest;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007183,biological_process SMAD protein complex assembly;GO:0007369,biological_process gastrulation;GO:0007492,biological_process endoderm development;GO:0008013,molecular_function beta-catenin binding;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009880,biological_process embryonic pattern specification;GO:0010628,biological_process positive regulation of gene expression;GO:0010694,biological_process positive regulation of alkaline phosphatase activity;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0016202,biological_process regulation of striated muscle tissue development;GO:0016579,biological_process protein deubiquitination;GO:0017015,biological_process regulation of transforming growth factor beta receptor signaling pathway;GO:0017151,molecular_function DEAD/H-box RNA helicase binding;GO:0019049,biological_process evasion or tolerance of host defenses by virus;GO:0019899,molecular_function enzyme binding;GO:0019901,molecular_function protein kinase binding;GO:0019902,molecular_function phosphatase binding;GO:0023019,biological_process signal transduction involved in regulation of gene expression;GO:0030308,biological_process negative regulation of cell growth;GO:0030335,biological_process positive regulation of cell migration;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030618,molecular_function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity;GO:0030878,biological_process thyroid gland development;GO:0031053,biological_process primary miRNA processing;GO:0031490,molecular_function chromatin DNA binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031962,molecular_function mineralocorticoid receptor binding;GO:0032332,biological_process positive regulation of chondrocyte differentiation;GO:0032731,biological_process positive regulation of interleukin-1 beta production;GO:0032909,biological_process regulation of transforming growth factor beta2 production;GO:0032916,biological_process positive regulation of transforming growth factor beta3 production;GO:0032924,biological_process activin receptor signaling pathway;GO:0033689,biological_process negative regulation of osteoblast proliferation;GO:0035259,molecular_function glucocorticoid receptor binding;GO:0035326,molecular_function enhancer binding;GO:0035413,biological_process positive regulation of catenin import into nucleus;GO:0038092,biological_process nodal signaling pathway;GO:0042060,biological_process wound healing;GO:0042110,biological_process T cell activation;GO:0042177,biological_process negative regulation of protein catabolic process;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042993,biological_process positive regulation of transcription factor import into nucleus;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043130,molecular_function ubiquitin binding;GO:0043234,cellular_component protein complex;GO:0043235,cellular_component receptor complex;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045216,biological_process cell-cell junction organization;GO:0045429,biological_process positive regulation of nitric oxide biosynthetic process;GO:0045599,biological_process negative regulation of fat cell differentiation;GO:0045668,biological_process negative regulation of osteoblast differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048340,biological_process paraxial mesoderm morphogenesis;GO:0048589,biological_process developmental growth;GO:0048617,biological_process embryonic foregut morphogenesis;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0050678,biological_process regulation of epithelial cell proliferation;GO:0050728,biological_process negative regulation of inflammatory response;GO:0050776,biological_process regulation of immune response;GO:0050821,biological_process protein stabilization;GO:0050927,biological_process positive regulation of positive chemotaxis;GO:0051098,biological_process regulation of binding;GO:0051481,biological_process negative regulation of cytosolic calcium ion concentration;GO:0051496,biological_process positive regulation of stress fiber assembly;GO:0051894,biological_process positive regulation of focal adhesion assembly;GO:0060039,biological_process pericardium development;GO:0060070,biological_process canonical Wnt signaling pathway;GO:0060290,biological_process transdifferentiation;GO:0060395,biological_process SMAD protein signal transduction;GO:0061045,biological_process negative regulation of wound healing;GO:0061767,biological_process negative regulation of lung blood pressure;GO:0070306,biological_process lens fiber cell differentiation;GO:0070410,molecular_function co-SMAD binding;GO:0070412,molecular_function R-SMAD binding;GO:0070878,molecular_function primary miRNA binding;GO:0071141,cellular_component SMAD protein complex;GO:0071144,cellular_component SMAD2-SMAD3 protein complex;GO:0071560,biological_process cellular response to transforming growth factor beta stimulus;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1901203,biological_process positive regulation of extracellular matrix assembly;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903243,biological_process negative regulation of cardiac muscle hypertrophy in response to stress	SMAD2; mothers against decapentaplegic homolog 2; K04500	SMAD family member 3 [Source:HGNC Symbol%3BAcc:HGNC:6769]
ENSG00000112306	1418.94	1232.22	1186.73	1292.30	1209.07	1359.13	0.00344611492915043	8.99036913899343	0.965386592350735	1	6:132814440-132817564:+	RPS12	16;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex	NA	ribosomal protein S12 [Source:HGNC Symbol%3BAcc:HGNC:10385]
ENSG00000152455	11.08	11.81	10.65	12.84	11.65	9.49	-0.00885109270986293	3.80406762033403	0.96559972371939	1	10:14878819-14904315:+	SUV39H2	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006333,biological_process chromatin assembly or disassembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0008168,molecular_function methyltransferase activity;GO:0008270,molecular_function zinc ion binding;GO:0016569,biological_process covalent chromatin modification;GO:0016740,molecular_function transferase activity;GO:0018024,molecular_function histone-lysine N-methyltransferase activity;GO:0030154,biological_process cell differentiation;GO:0032259,biological_process methylation;GO:0034968,biological_process histone lysine methylation;GO:0036123,biological_process histone H3-K9 dimethylation;GO:0036124,biological_process histone H3-K9 trimethylation;GO:0042754,biological_process negative regulation of circadian rhythm;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046974,molecular_function histone methyltransferase activity (H3-K9 specific);GO:0048511,biological_process rhythmic process;GO:0071456,biological_process cellular response to hypoxia;GO:1904047,molecular_function S-adenosyl-L-methionine binding	SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]; K11419	suppressor of variegation 3-9 homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:17287]
ENSG00000100647	6.45	6.52	5.99	6.18	6.84	6.19	-0.00888867836460847	2.56801711935145	0.965639678381438	1	14:69611595-69715142:+	SUSD6	7;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008219,biological_process cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	sushi domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:19956]
ENSG00000143319	22.81	24.18	25.23	25.31	24.06	23.17	0.00483424982866996	4.68407176590339	0.965753192612743	1	1:156721890-156728799:-	ISG20L2	14;GO:0000175,molecular_function 3'-5'-exoribonuclease activity;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0042254,biological_process ribosome biogenesis;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	interferon stimulated exonuclease gene 20 like 2 [Source:HGNC Symbol%3BAcc:HGNC:25745]
ENSG00000051341	3.04	2.76	2.66	2.95	2.96	2.66	-0.00363503321849604	4.54641055462	0.965782075732957	1	3:121431426-121546641:-	POLQ	28;GO:0000166,molecular_function nucleotide binding;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003684,molecular_function damaged DNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006260,biological_process DNA replication;GO:0006261,biological_process DNA-dependent DNA replication;GO:0006281,biological_process DNA repair;GO:0006284,biological_process base-excision repair;GO:0006302,biological_process double-strand break repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0016446,biological_process somatic hypermutation of immunoglobulin genes;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0043142,molecular_function single-stranded DNA-dependent ATPase activity;GO:0051260,biological_process protein homooligomerization;GO:0051575,molecular_function 5'-deoxyribose-5-phosphate lyase activity;GO:0071897,biological_process DNA biosynthetic process;GO:0097681,biological_process double-strand break repair via alternative nonhomologous end joining;GO:2000042,biological_process negative regulation of double-strand break repair via homologous recombination	NA	DNA polymerase theta [Source:HGNC Symbol%3BAcc:HGNC:9186]
ENSG00000125971	212.71	222.67	211.40	221.67	224.99	203.77	0.00290750006794199	6.78439998086532	0.965803650675455	1	20:34516408-34540958:+	DYNLRB1	18;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0007018,biological_process microtubule-based movement;GO:0007632,biological_process visual behavior;GO:0016020,cellular_component membrane;GO:0030286,cellular_component dynein complex;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036157,cellular_component outer dynein arm;GO:0045505,molecular_function dynein intermediate chain binding;GO:0097542,cellular_component ciliary tip	NA	dynein light chain roadblock-type 1 [Source:HGNC Symbol%3BAcc:HGNC:15468]
ENSG00000152413	2.99	4.41	2.70	2.40	3.36	4.24	0.00332210847385849	1.87861422768865	0.965883073097499	1	5:79372635-79514217:-	HOMER1	30;GO:0003009,biological_process skeletal muscle contraction;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007206,biological_process phospholipase C-activating G-protein coupled glutamate receptor signaling pathway;GO:0007268,biological_process chemical synaptic transmission;GO:0009967,biological_process positive regulation of signal transduction;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030018,cellular_component Z disc;GO:0030054,cellular_component cell junction;GO:0030424,cellular_component axon;GO:0035256,molecular_function G-protein coupled glutamate receptor binding;GO:0035591,molecular_function signaling adaptor activity;GO:0043005,cellular_component neuron projection;GO:0043034,cellular_component costamere;GO:0044325,molecular_function ion channel binding;GO:0045177,cellular_component apical part of cell;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048148,biological_process behavioral response to cocaine;GO:0048741,biological_process skeletal muscle fiber development;GO:0048875,biological_process chemical homeostasis within a tissue;GO:0051592,biological_process response to calcium ion;GO:0051928,biological_process positive regulation of calcium ion transport;GO:0090279,biological_process regulation of calcium ion import;GO:0098794,cellular_component postsynapse;GO:2001256,biological_process regulation of store-operated calcium entry;GO:2001257,biological_process regulation of cation channel activity	HOMER; homer; K15010	homer scaffolding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17512]
ENSG00000156150	4.74	4.27	4.65	4.15	5.75	4.03	-0.00746896635566668	2.28964782321112	0.965911339291321	1	1:110059993-110070700:-	ALX3	12;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0035116,biological_process embryonic hindlimb morphogenesis;GO:0042981,biological_process regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048701,biological_process embryonic cranial skeleton morphogenesis;GO:0048704,biological_process embryonic skeletal system morphogenesis	NA	ALX homeobox 3 [Source:HGNC Symbol%3BAcc:HGNC:449]
ENSG00000102870	6.04	7.33	6.69	6.43	6.72	6.93	0.000952383260853478	4.13426421351868	0.966247993524888	1	16:30778448-30787202:-	ZNF629	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 629 [Source:HGNC Symbol%3BAcc:HGNC:29008]
ENSG00000198755	932.35	906.18	942.91	963.21	898.23	947.84	-0.00248527327546543	9.24595377661334	0.966400150330022	1	6:35468407-35470785:+	RPL10A	20;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015934,cellular_component large ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0045471,biological_process response to ethanol;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein L10a [Source:HGNC Symbol%3BAcc:HGNC:10299]
ENSG00000143157	22.92	21.08	23.04	22.91	22.04	22.55	0.00571154276945332	5.36417760586885	0.966702322228551	1	1:166839446-166856344:+	POGK	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development	NA	pogo transposable element derived with KRAB domain [Source:HGNC Symbol%3BAcc:HGNC:18800]
ENSG00000154217	5.69	5.30	5.07	5.70	5.02	5.60	-0.0102891739019945	2.63053795481674	0.966744820924449	1	17:67377280-67697261:+	PITPNC1	14;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006869,biological_process lipid transport;GO:0007165,biological_process signal transduction;GO:0008289,molecular_function lipid binding;GO:0008526,molecular_function phosphatidylinositol transporter activity;GO:0015914,biological_process phospholipid transport;GO:0035091,molecular_function phosphatidylinositol binding;GO:0070300,molecular_function phosphatidic acid binding;GO:1901611,molecular_function phosphatidylglycerol binding	NA	phosphatidylinositol transfer protein%2C cytoplasmic 1 [Source:HGNC Symbol%3BAcc:HGNC:21045]
ENSG00000006042	43.37	45.88	45.96	46.64	42.44	46.71	0.00307967330053456	4.94628739312197	0.966823851147614	1	17:32927909-32945106:+	TMEM98	3;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	transmembrane protein 98 [Source:HGNC Symbol%3BAcc:HGNC:24529]
ENSG00000066084	5.02	5.40	5.53	5.07	5.66	5.28	0.00416419588302638	4.66267015695719	0.966825288189357	1	12:50504984-50748667:+	DIP2B	8;GO:0003674,molecular_function molecular_function;GO:0003824,molecular_function catalytic activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008150,biological_process biological_process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0070062,cellular_component extracellular exosome	NA	disco interacting protein 2 homolog B [Source:HGNC Symbol%3BAcc:HGNC:29284]
ENSG00000085224	27.05	28.44	28.12	27.64	29.10	27.70	-0.00289645369261078	7.77851102099183	0.966886372523904	1	X:77504877-77786269:-	ATRX	59;GO:0000166,molecular_function nucleotide binding;GO:0000212,biological_process meiotic spindle organization;GO:0000228,cellular_component nuclear chromosome;GO:0000780,cellular_component condensed nuclear chromosome, centromeric region;GO:0000781,cellular_component chromosome, telomeric region;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000792,cellular_component heterochromatin;GO:0003677,molecular_function DNA binding;GO:0003678,molecular_function DNA helicase activity;GO:0003682,molecular_function chromatin binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005720,cellular_component nuclear heterochromatin;GO:0005721,cellular_component pericentric heterochromatin;GO:0006281,biological_process DNA repair;GO:0006306,biological_process DNA methylation;GO:0006310,biological_process DNA recombination;GO:0006334,biological_process nucleosome assembly;GO:0006336,biological_process DNA replication-independent nucleosome assembly;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0010571,biological_process positive regulation of nuclear cell cycle DNA replication;GO:0015616,molecular_function DNA translocase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016604,cellular_component nuclear body;GO:0016605,cellular_component PML body;GO:0016787,molecular_function hydrolase activity;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0030900,biological_process forebrain development;GO:0031297,biological_process replication fork processing;GO:0031618,cellular_component nuclear pericentric heterochromatin;GO:0031933,cellular_component telomeric heterochromatin;GO:0032206,biological_process positive regulation of telomere maintenance;GO:0032508,biological_process DNA duplex unwinding;GO:0035064,molecular_function methylated histone binding;GO:0035128,biological_process post-embryonic forelimb morphogenesis;GO:0035264,biological_process multicellular organism growth;GO:0042393,molecular_function histone binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060009,biological_process Sertoli cell development;GO:0070087,molecular_function chromo shadow domain binding;GO:0070192,biological_process chromosome organization involved in meiotic cell cycle;GO:0070198,biological_process protein localization to chromosome, telomeric region;GO:0070603,cellular_component SWI/SNF superfamily-type complex;GO:0072520,biological_process seminiferous tubule development;GO:0072711,biological_process cellular response to hydroxyurea;GO:1900112,biological_process regulation of histone H3-K9 trimethylation;GO:1901581,biological_process negative regulation of telomeric RNA transcription from RNA pol II promoter;GO:1901582,biological_process positive regulation of telomeric RNA transcription from RNA pol II promoter;GO:1904908,biological_process negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric;GO:1990707,cellular_component nuclear subtelomeric heterochromatin	NA	ATRX%2C chromatin remodeler [Source:HGNC Symbol%3BAcc:HGNC:886]
ENSG00000168826	2.77	2.37	2.63	2.61	2.78	2.39	0.0224858754862116	2.61255959267243	0.966979946799478	1	4:4290250-4321786:+	ZBTB49	18;GO:0001223,molecular_function transcription coactivator binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007049,biological_process cell cycle;GO:0007050,biological_process cell cycle arrest;GO:0008134,molecular_function transcription factor binding;GO:0008285,biological_process negative regulation of cell proliferation;GO:0015630,cellular_component microtubule cytoskeleton;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger and BTB domain containing 49 [Source:HGNC Symbol%3BAcc:HGNC:19883]
ENSG00000111725	22.60	23.28	21.77	24.69	21.97	21.22	0.00520927203723178	4.23091244450907	0.967053086998087	1	12:119667752-119681630:+	PRKAB1	25;GO:0004672,molecular_function protein kinase activity;GO:0004679,molecular_function AMP-activated protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0007050,biological_process cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0010628,biological_process positive regulation of gene expression;GO:0016236,biological_process macroautophagy;GO:0016241,biological_process regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0031588,cellular_component nucleotide-activated protein kinase complex;GO:0035878,biological_process nail development;GO:0043234,cellular_component protein complex;GO:0045859,biological_process regulation of protein kinase activity;GO:0050790,biological_process regulation of catalytic activity;GO:0051291,biological_process protein heterooligomerization;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	PRKAB; 5'-AMP-activated protein kinase, regulatory beta subunit; K07199	protein kinase AMP-activated non-catalytic subunit beta 1 [Source:HGNC Symbol%3BAcc:HGNC:9378]
ENSG00000131724	67.12	67.78	67.67	66.63	69.43	68.57	-0.00310668680064959	6.45539060082641	0.967442466873317	1	X:118727571-118794539:+	IL13RA1	8;GO:0004896,molecular_function cytokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005898,cellular_component interleukin-13 receptor complex;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway	IL13RA1, CD213A1; interleukin 13 receptor alpha-1; K05076	interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol%3BAcc:HGNC:5974]
ENSG00000162976	25.87	28.08	26.65	25.24	26.30	29.28	0.00220939713900689	4.28282131932071	0.967547361372066	1	2:11155197-11178874:+	PQLC3	3;GO:0006488,biological_process dolichol-linked oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	PQ loop repeat containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28503]
ENSG00000023318	53.29	60.96	56.02	58.09	56.23	56.75	0.00153301182615409	6.1172916144288	0.96773869378431	1	9:99979178-100099040:-	ERP44	16;GO:0003756,molecular_function protein disulfide isomerase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005783,cellular_component endoplasmic reticulum;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006457,biological_process protein folding;GO:0006986,biological_process response to unfolded protein;GO:0009100,biological_process glycoprotein metabolic process;GO:0009986,cellular_component cell surface;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035580,cellular_component specific granule lumen;GO:0043312,biological_process neutrophil degranulation;GO:0045454,biological_process cell redox homeostasis;GO:0070062,cellular_component extracellular exosome	NA	endoplasmic reticulum protein 44 [Source:HGNC Symbol%3BAcc:HGNC:18311]
ENSG00000088727	5.11	4.46	5.48	5.24	3.88	5.98	0.010395080656653	3.64384981434552	0.967744567150182	1	3:47228025-47283451:-	KIF9	18;GO:0000166,molecular_function nucleotide binding;GO:0002102,cellular_component podosome;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0016887,molecular_function ATPase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0031982,cellular_component vesicle;GO:0046983,molecular_function protein dimerization activity;GO:0071801,biological_process regulation of podosome assembly;GO:1903008,biological_process organelle disassembly	NA	kinesin family member 9 [Source:HGNC Symbol%3BAcc:HGNC:16666]
ENSG00000116791	232.91	259.68	218.19	226.89	255.96	231.97	0.00275674290511187	7.87480136918844	0.968075783762643	1	1:74705481-74733408:-	CRYZ	13;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0003960,molecular_function NADPH:quinone reductase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007601,biological_process visual perception;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0042178,biological_process xenobiotic catabolic process;GO:0051289,biological_process protein homotetramerization;GO:0055114,biological_process oxidation-reduction process;GO:0070062,cellular_component extracellular exosome;GO:0070402,molecular_function NADPH binding	NA	crystallin zeta [Source:HGNC Symbol%3BAcc:HGNC:2419]
ENSG00000221926	38.20	40.55	39.33	39.86	40.75	38.63	-0.00363673328414036	6.31453764020788	0.96823250709003	1	17:15627959-15684311:-	TRIM16	22;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0016605,cellular_component PML body;GO:0019966,molecular_function interleukin-1 binding;GO:0032089,molecular_function NACHT domain binding;GO:0032526,biological_process response to retinoic acid;GO:0043966,biological_process histone H3 acetylation;GO:0043967,biological_process histone H4 acetylation;GO:0045618,biological_process positive regulation of keratinocyte differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046683,biological_process response to organophosphorus;GO:0046872,molecular_function metal ion binding;GO:0048386,biological_process positive regulation of retinoic acid receptor signaling pathway;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0060416,biological_process response to growth hormone	NA	tripartite motif containing 16 [Source:HGNC Symbol%3BAcc:HGNC:17241]
ENSG00000144034	34.32	34.53	31.07	33.47	33.79	33.84	-0.00795953989090236	4.43692409442586	0.968373679834487	1	2:73729103-73737400:-	TPRKB	7;GO:0000408,cellular_component EKC/KEOPS complex;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008033,biological_process tRNA processing;GO:0019901,molecular_function protein kinase binding	NA	TP53RK binding protein [Source:HGNC Symbol%3BAcc:HGNC:24259]
ENSG00000089916	13.97	15.27	15.20	15.59	14.17	14.84	0.00307846983056148	4.6935784002253	0.968433168497012	1	14:76151915-76254342:+	GPATCH2L	1;GO:0005515,molecular_function protein binding	NA	G-patch domain containing 2 like [Source:HGNC Symbol%3BAcc:HGNC:20210]
ENSG00000179981	6.71	6.80	6.70	6.42	6.81	7.20	-0.00587778823364237	4.46276783763845	0.968571302402134	1	18:75210754-75289950:+	TSHZ1	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010468,biological_process regulation of gene expression;GO:0042474,biological_process middle ear morphogenesis;GO:0046872,molecular_function metal ion binding;GO:0060023,biological_process soft palate development	TSHZ; teashirt; K09236	teashirt zinc finger homeobox 1 [Source:HGNC Symbol%3BAcc:HGNC:10669]
ENSG00000130764	24.60	26.87	24.96	26.16	26.09	24.53	0.00210536262793211	5.56281616470308	0.968575642495841	1	1:3778557-3796504:-	LRRC47	3;GO:0003723,molecular_function RNA binding;GO:0004826,molecular_function phenylalanine-tRNA ligase activity;GO:0005515,molecular_function protein binding	NA	leucine rich repeat containing 47 [Source:HGNC Symbol%3BAcc:HGNC:29207]
ENSG00000137710	58.28	58.98	56.36	57.68	60.80	56.87	-0.00299059993773639	6.8287973761193	0.968910468628648	1	11:110174879-110296722:-	RDX	58;GO:0001726,cellular_component ruffle;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005913,cellular_component cell-cell adherens junction;GO:0005925,cellular_component focal adhesion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0008360,biological_process regulation of cell shape;GO:0008361,biological_process regulation of cell size;GO:0010628,biological_process positive regulation of gene expression;GO:0010737,biological_process protein kinase A signaling;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030027,cellular_component lamellipodium;GO:0030033,biological_process microvillus assembly;GO:0030175,cellular_component filopodium;GO:0030315,cellular_component T-tubule;GO:0030335,biological_process positive regulation of cell migration;GO:0030496,cellular_component midbody;GO:0030864,cellular_component cortical actin cytoskeleton;GO:0032154,cellular_component cleavage furrow;GO:0032231,biological_process regulation of actin filament bundle assembly;GO:0032420,cellular_component stereocilium;GO:0032487,biological_process regulation of Rap protein signal transduction;GO:0034111,biological_process negative regulation of homotypic cell-cell adhesion;GO:0034260,biological_process negative regulation of GTPase activity;GO:0036120,biological_process cellular response to platelet-derived growth factor stimulus;GO:0042803,molecular_function protein homodimerization activity;GO:0043087,biological_process regulation of GTPase activity;GO:0043209,cellular_component myelin sheath;GO:0045176,biological_process apical protein localization;GO:0045177,cellular_component apical part of cell;GO:0045184,biological_process establishment of protein localization;GO:0045296,molecular_function cadherin binding;GO:0045792,biological_process negative regulation of cell size;GO:0051016,biological_process barbed-end actin filament capping;GO:0051018,molecular_function protein kinase A binding;GO:0051117,molecular_function ATPase binding;GO:0051286,cellular_component cell tip;GO:0051693,biological_process actin filament capping;GO:0061028,biological_process establishment of endothelial barrier;GO:0070062,cellular_component extracellular exosome;GO:0071944,cellular_component cell periphery;GO:0090002,biological_process establishment of protein localization to plasma membrane;GO:0097067,biological_process cellular response to thyroid hormone stimulus;GO:1900027,biological_process regulation of ruffle assembly;GO:1900087,biological_process positive regulation of G1/S transition of mitotic cell cycle;GO:1902115,biological_process regulation of organelle assembly;GO:1902966,biological_process positive regulation of protein localization to early endosome;GO:1903364,biological_process positive regulation of cellular protein catabolic process;GO:1903392,biological_process negative regulation of adherens junction organization;GO:2000643,biological_process positive regulation of early endosome to late endosome transport	RDX; radixin; K05762	radixin [Source:HGNC Symbol%3BAcc:HGNC:9944]
ENSG00000154059	30.26	22.32	27.58	25.17	26.28	29.27	0.00894495764444226	4.84589871503595	0.969017614075433	1	18:24426615-24453535:+	IMPACT	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0005844,cellular_component polysome;GO:0006417,biological_process regulation of translation;GO:0006446,biological_process regulation of translational initiation;GO:0007399,biological_process nervous system development;GO:0008150,biological_process biological_process;GO:0030154,biological_process cell differentiation;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031953,biological_process negative regulation of protein autophosphorylation;GO:0034198,biological_process cellular response to amino acid starvation;GO:0042149,biological_process cellular response to glucose starvation;GO:0043022,molecular_function ribosome binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0060548,biological_process negative regulation of cell death;GO:0060733,biological_process regulation of eIF2 alpha phosphorylation by amino acid starvation;GO:0070301,biological_process cellular response to hydrogen peroxide;GO:0071264,biological_process positive regulation of translational initiation in response to starvation;GO:0071468,biological_process cellular response to acidic pH;GO:0071494,biological_process cellular response to UV-C;GO:0072755,biological_process cellular response to benomyl;GO:0097201,biological_process negative regulation of transcription from RNA polymerase II promoter in response to stress;GO:1990138,biological_process neuron projection extension;GO:1990253,biological_process cellular response to leucine starvation	NA	impact RWD domain protein [Source:HGNC Symbol%3BAcc:HGNC:20387]
ENSG00000164187	7.79	9.35	6.95	7.72	8.44	7.93	0.00201870435579906	4.0728685065261	0.969099047459006	1	5:36098411-36151961:-	LMBRD2	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	LMBR1 domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25287]
ENSG00000110801	21.79	20.64	19.02	23.19	21.15	17.26	0.00968772396970232	4.00905921741906	0.969101880047847	1	12:121888730-121918297:+	PSMD9	38;GO:0000165,biological_process MAPK cascade;GO:0000209,biological_process protein polyubiquitination;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0003713,molecular_function transcription coactivator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005838,cellular_component proteasome regulatory particle;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006521,biological_process regulation of cellular amino acid metabolic process;GO:0008540,cellular_component proteasome regulatory particle, base subcomplex;GO:0010972,biological_process negative regulation of G2/M transition of mitotic cell cycle;GO:0016579,biological_process protein deubiquitination;GO:0031145,biological_process anaphase-promoting complex-dependent catabolic process;GO:0031146,biological_process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0032024,biological_process positive regulation of insulin secretion;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043488,biological_process regulation of mRNA stability;GO:0043687,biological_process post-translational protein modification;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046676,biological_process negative regulation of insulin secretion;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051436,biological_process negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051437,biological_process positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;GO:0055085,biological_process transmembrane transport;GO:0060071,biological_process Wnt signaling pathway, planar cell polarity pathway;GO:0061418,biological_process regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070682,biological_process proteasome regulatory particle assembly;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:1902036,biological_process regulation of hematopoietic stem cell differentiation	NA	proteasome 26S subunit%2C non-ATPase 9 [Source:HGNC Symbol%3BAcc:HGNC:9567]
ENSG00000160439	5.61	6.34	7.10	6.10	6.25	7.00	-0.0140297954657615	2.7055883394147	0.969360826161595	1	19:55039107-55071291:-	RDH13	9;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0009644,biological_process response to high light intensity;GO:0010842,biological_process retina layer formation;GO:0016491,molecular_function oxidoreductase activity;GO:0042462,biological_process eye photoreceptor cell development;GO:0042572,biological_process retinol metabolic process;GO:0052650,molecular_function NADP-retinol dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process	NA	retinol dehydrogenase 13 [Source:HGNC Symbol%3BAcc:HGNC:19978]
ENSG00000147099	37.91	36.62	36.45	34.86	40.04	37.30	-0.00312975476246987	5.54482500934838	0.969509793822663	1	X:72329515-72573103:-	HDAC8	28;GO:0000118,cellular_component histone deacetylase complex;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000228,cellular_component nuclear chromosome;GO:0004407,molecular_function histone deacetylase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006325,biological_process chromatin organization;GO:0006333,biological_process chromatin assembly or disassembly;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007062,biological_process sister chromatid cohesion;GO:0008134,molecular_function transcription factor binding;GO:0016569,biological_process covalent chromatin modification;GO:0016575,biological_process histone deacetylation;GO:0016787,molecular_function hydrolase activity;GO:0030544,molecular_function Hsp70 protein binding;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031647,biological_process regulation of protein stability;GO:0032041,molecular_function NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0032204,biological_process regulation of telomere maintenance;GO:0046872,molecular_function metal ion binding;GO:0051879,molecular_function Hsp90 protein binding;GO:0070932,biological_process histone H3 deacetylation;GO:0071922,biological_process regulation of cohesin loading	HDAC8; histone deacetylase 8 [EC:3.5.1.98]; K11405	histone deacetylase 8 [Source:HGNC Symbol%3BAcc:HGNC:13315]
ENSG00000183765	11.70	11.57	10.90	12.25	11.11	10.99	0.00369817953644532	4.47355274164688	0.969710971120314	1	22:28687742-28742422:-	CHEK2	57;GO:0000077,biological_process DNA damage checkpoint;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000781,cellular_component chromosome, telomeric region;GO:0001302,biological_process replicative cell aging;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006975,biological_process DNA damage induced protein phosphorylation;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007049,biological_process cell cycle;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010332,biological_process response to gamma radiation;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016605,cellular_component PML body;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035690,biological_process cellular response to drug;GO:0042176,biological_process regulation of protein catabolic process;GO:0042770,biological_process signal transduction in response to DNA damage;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0044257,biological_process cellular protein catabolic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0051301,biological_process cell division;GO:0071157,biological_process negative regulation of cell cycle arrest;GO:0071480,biological_process cellular response to gamma radiation;GO:0072428,biological_process signal transduction involved in intra-S DNA damage checkpoint;GO:0090307,biological_process mitotic spindle assembly;GO:0090399,biological_process replicative senescence;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1903416,biological_process response to glycoside;GO:1903926,biological_process cellular response to bisphenol A;GO:2000002,biological_process negative regulation of DNA damage checkpoint;GO:2000210,biological_process positive regulation of anoikis	CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]; K06641	checkpoint kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:16627]
ENSG00000114686	80.38	91.92	87.85	88.18	89.51	85.00	-0.0038564959019837	6.78077839516855	0.969721555413581	1	3:131462211-131502983:-	MRPL3	11;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3; K02906	mitochondrial ribosomal protein L3 [Source:HGNC Symbol%3BAcc:HGNC:10379]
ENSG00000141551	94.14	98.01	97.41	100.00	94.70	97.71	-0.00290058503471443	7.17162209841944	0.969750884014871	1	17:82239022-82273731:-	CSNK1D	54;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0000139,cellular_component Golgi membrane;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005876,cellular_component spindle microtubule;GO:0005886,cellular_component plasma membrane;GO:0006364,biological_process rRNA processing;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0007020,biological_process microtubule nucleation;GO:0007030,biological_process Golgi organization;GO:0008360,biological_process regulation of cell shape;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0016020,cellular_component membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032922,biological_process circadian regulation of gene expression;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0034067,biological_process protein localization to Golgi apparatus;GO:0042277,molecular_function peptide binding;GO:0042752,biological_process regulation of circadian rhythm;GO:0043005,cellular_component neuron projection;GO:0045296,molecular_function cadherin binding;GO:0048208,biological_process COPII vesicle coating;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048511,biological_process rhythmic process;GO:0050321,molecular_function tau-protein kinase activity;GO:0051225,biological_process spindle assembly;GO:0061512,biological_process protein localization to cilium;GO:0071539,biological_process protein localization to centrosome;GO:0090263,biological_process positive regulation of canonical Wnt signaling pathway;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:1905426,biological_process positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation;GO:1905515,biological_process non-motile cilium assembly;GO:1990090,biological_process cellular response to nerve growth factor stimulus;GO:2000052,biological_process positive regulation of non-canonical Wnt signaling pathway	CSNK1D; casein kinase 1, delta [EC:2.7.11.1]; K08959	casein kinase 1 delta [Source:HGNC Symbol%3BAcc:HGNC:2452]
ENSG00000067606	10.67	10.01	11.16	10.17	10.30	11.77	-0.00367062602622393	4.4058813588623	0.969847553155098	1	1:2050469-2185395:+	PRKCZ	87;GO:0000166,molecular_function nucleotide binding;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0001954,biological_process positive regulation of cell-matrix adhesion;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004697,molecular_function protein kinase C activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0005938,cellular_component cell cortex;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007616,biological_process long-term memory;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008286,biological_process insulin receptor signaling pathway;GO:0015459,molecular_function potassium channel regulator activity;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016363,cellular_component nuclear matrix;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030010,biological_process establishment of cell polarity;GO:0030054,cellular_component cell junction;GO:0031252,cellular_component cell leading edge;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031532,biological_process actin cytoskeleton reorganization;GO:0031584,biological_process activation of phospholipase D activity;GO:0031941,cellular_component filamentous actin;GO:0031982,cellular_component vesicle;GO:0032148,biological_process activation of protein kinase B activity;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0032869,biological_process cellular response to insulin stimulus;GO:0034613,biological_process cellular protein localization;GO:0035556,biological_process intracellular signal transduction;GO:0035748,cellular_component myelin sheath abaxonal region;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043203,cellular_component axon hillock;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0043274,molecular_function phospholipase binding;GO:0043560,molecular_function insulin receptor substrate binding;GO:0045121,cellular_component membrane raft;GO:0045179,cellular_component apical cortex;GO:0045630,biological_process positive regulation of T-helper 2 cell differentiation;GO:0046326,biological_process positive regulation of glucose import;GO:0046627,biological_process negative regulation of insulin receptor signaling pathway;GO:0046628,biological_process positive regulation of insulin receptor signaling pathway;GO:0046872,molecular_function metal ion binding;GO:0047496,biological_process vesicle transport along microtubule;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050732,biological_process negative regulation of peptidyl-tyrosine phosphorylation;GO:0050806,biological_process positive regulation of synaptic transmission;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051222,biological_process positive regulation of protein transport;GO:0051291,biological_process protein heterooligomerization;GO:0051346,biological_process negative regulation of hydrolase activity;GO:0051899,biological_process membrane depolarization;GO:0060081,biological_process membrane hyperpolarization;GO:0060291,biological_process long-term synaptic potentiation;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070528,biological_process protein kinase C signaling;GO:0071889,molecular_function 14-3-3 protein binding;GO:0072659,biological_process protein localization to plasma membrane;GO:1990138,biological_process neuron projection extension;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000553,biological_process positive regulation of T-helper 2 cell cytokine production;GO:2000664,biological_process positive regulation of interleukin-5 secretion;GO:2000667,biological_process positive regulation of interleukin-13 secretion;GO:2001181,biological_process positive regulation of interleukin-10 secretion	PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]; K06069	protein kinase C zeta [Source:HGNC Symbol%3BAcc:HGNC:9412]
ENSG00000115590	29.73	29.83	31.66	31.39	29.77	31.07	-0.00342702815874064	5.19857301068333	0.969888459826811	1	2:101991843-102028544:+	IL1R2	15;GO:0004908,molecular_function interleukin-1 receptor activity;GO:0004910,molecular_function interleukin-1, Type II, blocking receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006955,biological_process immune response;GO:0010955,biological_process negative regulation of protein processing;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0019966,molecular_function interleukin-1 binding;GO:0050712,biological_process negative regulation of interleukin-1 alpha secretion;GO:1900016,biological_process negative regulation of cytokine production involved in inflammatory response;GO:2000660,biological_process negative regulation of interleukin-1-mediated signaling pathway	IL1R2, CD121b; interleukin 1 receptor type II; K04387	interleukin 1 receptor type 2 [Source:HGNC Symbol%3BAcc:HGNC:5994]
ENSG00000148572	23.90	20.34	23.06	20.76	23.35	23.72	0.00714390667738742	4.3818330579438	0.970155084446819	1	10:63133246-63155031:+	NRBF2	13;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006914,biological_process autophagy;GO:0031410,cellular_component cytoplasmic vesicle;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035032,cellular_component phosphatidylinositol 3-kinase complex, class III;GO:0043550,biological_process regulation of lipid kinase activity	NA	nuclear receptor binding factor 2 [Source:HGNC Symbol%3BAcc:HGNC:19692]
ENSG00000089094	9.12	9.76	9.47	9.79	9.12	9.57	0.00205579174354325	5.33975978259229	0.970215469608378	1	12:121429096-121581015:-	KDM2B	36;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000979,molecular_function RNA polymerase II core promoter sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0019843,molecular_function rRNA binding;GO:0021555,biological_process midbrain-hindbrain boundary morphogenesis;GO:0021592,biological_process fourth ventricle development;GO:0021670,biological_process lateral ventricle development;GO:0021678,biological_process third ventricle development;GO:0021993,biological_process initiation of neural tube closure;GO:0030307,biological_process positive regulation of cell growth;GO:0030900,biological_process forebrain development;GO:0030901,biological_process midbrain development;GO:0030902,biological_process hindbrain development;GO:0031519,cellular_component PcG protein complex;GO:0032452,molecular_function histone demethylase activity;GO:0035518,biological_process histone H2A monoubiquitination;GO:0043524,biological_process negative regulation of neuron apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0048596,biological_process embryonic camera-type eye morphogenesis;GO:0051213,molecular_function dioxygenase activity;GO:0051864,molecular_function histone demethylase activity (H3-K36 specific);GO:0055114,biological_process oxidation-reduction process;GO:0070544,biological_process histone H3-K36 demethylation;GO:1902459,biological_process positive regulation of stem cell population maintenance;GO:2000178,biological_process negative regulation of neural precursor cell proliferation	NA	lysine demethylase 2B [Source:HGNC Symbol%3BAcc:HGNC:13610]
ENSG00000104312	57.07	53.87	56.23	55.67	54.74	58.52	-0.00235783781264224	6.54021373001959	0.970324881552575	1	8:89757746-89791063:+	RIPK2	82;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001961,biological_process positive regulation of cytokine-mediated signaling pathway;GO:0002250,biological_process adaptive immune response;GO:0002376,biological_process immune system process;GO:0002827,biological_process positive regulation of T-helper 1 type immune response;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004715,molecular_function non-membrane spanning protein tyrosine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007254,biological_process JNK cascade;GO:0010800,biological_process positive regulation of peptidyl-threonine phosphorylation;GO:0010942,biological_process positive regulation of cell death;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030274,molecular_function LIM domain binding;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0031982,cellular_component vesicle;GO:0032092,biological_process positive regulation of protein binding;GO:0032722,biological_process positive regulation of chemokine production;GO:0032727,biological_process positive regulation of interferon-alpha production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032735,biological_process positive regulation of interleukin-12 production;GO:0032743,biological_process positive regulation of interleukin-2 production;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0032760,biological_process positive regulation of tumor necrosis factor production;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0033091,biological_process positive regulation of immature T cell proliferation;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034134,biological_process toll-like receptor 2 signaling pathway;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0042098,biological_process T cell proliferation;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043234,cellular_component protein complex;GO:0043330,biological_process response to exogenous dsRNA;GO:0045087,biological_process innate immune response;GO:0045627,biological_process positive regulation of T-helper 1 cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046330,biological_process positive regulation of JNK cascade;GO:0046641,biological_process positive regulation of alpha-beta T cell proliferation;GO:0050700,molecular_function CARD domain binding;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070423,biological_process nucleotide-binding oligomerization domain containing signaling pathway;GO:0070427,biological_process nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431,biological_process nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070555,biological_process response to interleukin-1;GO:0070671,biological_process response to interleukin-12;GO:0070673,biological_process response to interleukin-18;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071223,biological_process cellular response to lipoteichoic acid;GO:0071224,biological_process cellular response to peptidoglycan;GO:0071225,biological_process cellular response to muramyl dipeptide;GO:0089720,molecular_function caspase binding;GO:0097202,biological_process activation of cysteine-type endopeptidase activity;GO:1904417,biological_process positive regulation of xenophagy	RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]; K08846	receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:10020]
ENSG00000149923	109.51	115.75	113.49	116.96	108.75	115.07	0.00212947831327025	6.87839261582328	0.970600369407524	1	16:30075977-30085377:+	PPP4C	17;GO:0004704,molecular_function NF-kappaB-inducing kinase activity;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006470,biological_process protein dephosphorylation;GO:0010569,biological_process regulation of double-strand break repair via homologous recombination;GO:0016787,molecular_function hydrolase activity;GO:0030289,cellular_component protein phosphatase 4 complex;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0046872,molecular_function metal ion binding	NA	protein phosphatase 4 catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9319]
ENSG00000166171	37.59	35.59	34.32	37.44	33.81	36.81	0.00475134349699126	4.62516291344816	0.970611737653833	1	10:101570559-101609668:+	DPCD	10;GO:0003351,biological_process epithelial cilium movement;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0007283,biological_process spermatogenesis;GO:0007368,biological_process determination of left/right symmetry;GO:0021591,biological_process ventricular system development;GO:0021670,biological_process lateral ventricle development;GO:0021678,biological_process third ventricle development;GO:0030317,biological_process sperm motility;GO:0060972,biological_process left/right pattern formation	NA	deleted in primary ciliary dyskinesia homolog (mouse) [Source:HGNC Symbol%3BAcc:HGNC:24542]
ENSG00000100906	40.33	43.61	38.70	40.31	40.59	42.22	0.00112916407643621	5.28855805287445	0.970791660169417	1	14:35401510-35404749:-	NFKBIA	55;GO:0000060,biological_process protein import into nucleus, translocation;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0007253,biological_process cytoplasmic sequestering of NF-kappaB;GO:0008134,molecular_function transcription factor binding;GO:0008139,molecular_function nuclear localization sequence binding;GO:0010468,biological_process regulation of gene expression;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010875,biological_process positive regulation of cholesterol efflux;GO:0010888,biological_process negative regulation of lipid storage;GO:0016032,biological_process viral process;GO:0016579,biological_process protein deubiquitination;GO:0019899,molecular_function enzyme binding;GO:0031072,molecular_function heat shock protein binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031663,biological_process lipopolysaccharide-mediated signaling pathway;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032270,biological_process positive regulation of cellular protein metabolic process;GO:0032403,molecular_function protein complex binding;GO:0032495,biological_process response to muramyl dipeptide;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0033256,cellular_component I-kappaB/NF-kappaB complex;GO:0034142,biological_process toll-like receptor 4 signaling pathway;GO:0035994,biological_process response to muscle stretch;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042345,biological_process regulation of NF-kappaB import into nucleus;GO:0042802,molecular_function identical protein binding;GO:0042994,biological_process cytoplasmic sequestering of transcription factor;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043234,cellular_component protein complex;GO:0043330,biological_process response to exogenous dsRNA;GO:0043392,biological_process negative regulation of DNA binding;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050852,biological_process T cell receptor signaling pathway;GO:0051059,molecular_function NF-kappaB binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0070417,biological_process cellular response to cold;GO:0070427,biological_process nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431,biological_process nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071345,biological_process cellular response to cytokine stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0097421,biological_process liver regeneration	NFKBIA; NF-kappa-B inhibitor alpha; K04734	NFKB inhibitor alpha [Source:HGNC Symbol%3BAcc:HGNC:7797]
ENSG00000198382	7.82	8.57	9.29	8.26	7.93	9.58	0.00342623642735699	4.29858253070806	0.970902725456904	1	11:75815166-76143195:+	UVRAG	35;GO:0000149,molecular_function SNARE binding;GO:0000775,cellular_component chromosome, centromeric region;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005813,cellular_component centrosome;GO:0006281,biological_process DNA repair;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0006914,biological_process autophagy;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007051,biological_process spindle organization;GO:0007059,biological_process chromosome segregation;GO:0007098,biological_process centrosome cycle;GO:0010508,biological_process positive regulation of autophagy;GO:0017124,molecular_function SH3 domain binding;GO:0030496,cellular_component midbody;GO:0030897,cellular_component HOPS complex;GO:0032465,biological_process regulation of cytokinesis;GO:0032801,biological_process receptor catabolic process;GO:0035493,biological_process SNARE complex assembly;GO:0043234,cellular_component protein complex;GO:0045335,cellular_component phagocytic vesicle;GO:0046718,biological_process viral entry into host cell;GO:0051684,biological_process maintenance of Golgi location;GO:0060627,biological_process regulation of vesicle-mediated transport;GO:0070418,cellular_component DNA-dependent protein kinase complex;GO:0071900,biological_process regulation of protein serine/threonine kinase activity;GO:0071985,biological_process multivesicular body sorting pathway;GO:0097680,biological_process double-strand break repair via classical nonhomologous end joining;GO:1901098,biological_process positive regulation of autophagosome maturation	NA	UV radiation resistance associated [Source:HGNC Symbol%3BAcc:HGNC:12640]
ENSG00000131116	32.28	28.68	34.97	30.26	33.06	33.30	0.0080259433017523	4.42592845959109	0.970973885502256	1	19:43607218-43619874:-	ZNF428	2;GO:0003676,molecular_function nucleic acid binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 428 [Source:HGNC Symbol%3BAcc:HGNC:20804]
ENSG00000107758	27.53	26.55	27.88	27.92	28.11	26.47	0.00441343468415786	5.56840039201689	0.970979429940245	1	10:73436427-73496024:-	PPP3CB	46;GO:0001915,biological_process negative regulation of T cell mediated cytotoxicity;GO:0001946,biological_process lymphangiogenesis;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005955,cellular_component calcineurin complex;GO:0006468,biological_process protein phosphorylation;GO:0006470,biological_process protein dephosphorylation;GO:0007165,biological_process signal transduction;GO:0007223,biological_process Wnt signaling pathway, calcium modulating pathway;GO:0007507,biological_process heart development;GO:0007612,biological_process learning;GO:0007613,biological_process memory;GO:0008144,molecular_function drug binding;GO:0010468,biological_process regulation of gene expression;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0017156,biological_process calcium ion regulated exocytosis;GO:0019899,molecular_function enzyme binding;GO:0030018,cellular_component Z disc;GO:0030217,biological_process T cell differentiation;GO:0030315,cellular_component T-tubule;GO:0030346,molecular_function protein phosphatase 2B binding;GO:0031987,biological_process locomotion involved in locomotory behavior;GO:0033173,biological_process calcineurin-NFAT signaling cascade;GO:0033192,molecular_function calmodulin-dependent protein phosphatase activity;GO:0034097,biological_process response to cytokine;GO:0035176,biological_process social behavior;GO:0035690,biological_process cellular response to drug;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042098,biological_process T cell proliferation;GO:0042110,biological_process T cell activation;GO:0043029,biological_process T cell homeostasis;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046983,molecular_function protein dimerization activity;GO:0048167,biological_process regulation of synaptic plasticity;GO:0048675,biological_process axon extension;GO:0050796,biological_process regulation of insulin secretion	PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]; K04348	protein phosphatase 3 catalytic subunit beta [Source:HGNC Symbol%3BAcc:HGNC:9315]
ENSG00000069966	14.92	16.97	16.77	16.06	15.01	18.06	-0.00804680478909555	4.38521868821002	0.971098397258912	1	15:52115104-52191369:-	GNB5	20;GO:0001750,cellular_component photoreceptor outer segment;GO:0001917,cellular_component photoreceptor inner segment;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006457,biological_process protein folding;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007212,biological_process dopamine receptor signaling pathway;GO:0016020,cellular_component membrane;GO:0031682,molecular_function G-protein gamma-subunit binding;GO:0043209,cellular_component myelin sheath;GO:0043547,biological_process positive regulation of GTPase activity;GO:0051087,molecular_function chaperone binding;GO:1901386,biological_process negative regulation of voltage-gated calcium channel activity;GO:1902773,cellular_component GTPase activator complex	GNB5; guanine nucleotide-binding protein subunit beta-5; K04539	G protein subunit beta 5 [Source:HGNC Symbol%3BAcc:HGNC:4401]
ENSG00000155008	6.89	6.29	7.81	7.40	8.42	5.66	-0.00958281523307867	2.57677646507126	0.971156640156463	1	X:85003825-85093316:+	APOOL	10;GO:0002576,biological_process platelet degranulation;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031093,cellular_component platelet alpha granule lumen;GO:0042407,biological_process cristae formation;GO:0061617,cellular_component MICOS complex	NA	apolipoprotein O like [Source:HGNC Symbol%3BAcc:HGNC:24009]
ENSG00000155158	3.54	2.94	3.62	3.51	3.05	3.59	0.0151408207863583	2.87285816044935	0.971257214439284	1	9:15163621-15307360:-	TTC39B	NA	NA	tetratricopeptide repeat domain 39B [Source:HGNC Symbol%3BAcc:HGNC:23704]
ENSG00000204574	40.38	43.49	41.61	40.95	46.14	39.65	-0.00332718311102808	6.7395520299931	0.971357780576698	1	6:30571375-30597179:+	ABCF1	16;GO:0000166,molecular_function nucleotide binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0006954,biological_process inflammatory response;GO:0008135,molecular_function translation factor activity, RNA binding;GO:0016020,cellular_component membrane;GO:0016887,molecular_function ATPase activity;GO:0055085,biological_process transmembrane transport	NA	ATP binding cassette subfamily F member 1 [Source:HGNC Symbol%3BAcc:HGNC:70]
ENSG00000102984	5.44	5.47	4.27	4.34	5.90	5.19	-0.0181852209980083	2.71470853434486	0.972069375031169	1	16:71859679-71895336:-	ZNF821	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 821 [Source:HGNC Symbol%3BAcc:HGNC:28043]
ENSG00000185000	20.36	20.11	18.90	21.12	19.53	19.02	0.00397859811623935	4.86801714874544	0.972268283608144	1	8:144314583-144326910:-	DGAT1	25;GO:0003846,molecular_function 2-acylglycerol O-acyltransferase activity;GO:0004144,molecular_function diacylglycerol O-acyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006641,biological_process triglyceride metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019432,biological_process triglyceride biosynthetic process;GO:0019915,biological_process lipid storage;GO:0034379,biological_process very-low-density lipoprotein particle assembly;GO:0035336,biological_process long-chain fatty-acyl-CoA metabolic process;GO:0035579,cellular_component specific granule membrane;GO:0036155,biological_process acylglycerol acyl-chain remodeling;GO:0042572,biological_process retinol metabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043312,biological_process neutrophil degranulation;GO:0046339,biological_process diacylglycerol metabolic process;GO:0046486,biological_process glycerolipid metabolic process;GO:0050252,molecular_function retinol O-fatty-acyltransferase activity;GO:0055089,biological_process fatty acid homeostasis	DGAT1; diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]; K11155	diacylglycerol O-acyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:2843]
ENSG00000010165	18.69	19.51	16.85	18.92	19.71	16.67	0.00307166083938507	5.27372176893925	0.972524143242956	1	1:171781663-171814023:+	METTL13	5;GO:0005515,molecular_function protein binding;GO:0008152,biological_process metabolic process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	methyltransferase like 13 [Source:HGNC Symbol%3BAcc:HGNC:24248]
ENSG00000215012	5.89	5.51	4.79	4.18	6.67	5.28	0.0170208669696395	2.59232737917783	0.972587403395819	1	22:19846137-19854896:-	RTL10	5;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0006915,biological_process apoptotic process;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0097345,biological_process mitochondrial outer membrane permeabilization	NA	retrotransposon Gag like 10 [Source:HGNC Symbol%3BAcc:HGNC:26112]
ENSG00000027847	21.52	26.54	23.82	23.79	25.15	23.11	0.00112827432734646	4.59144496504017	0.972663886089822	1	5:177600099-177610347:+	B4GALT7	22;GO:0000139,cellular_component Golgi membrane;GO:0003831,molecular_function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006029,biological_process proteoglycan metabolic process;GO:0006464,biological_process cellular protein modification process;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0008378,molecular_function galactosyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030145,molecular_function manganese ion binding;GO:0030203,biological_process glycosaminoglycan metabolic process;GO:0032580,cellular_component Golgi cisterna membrane;GO:0046525,molecular_function xylosylprotein 4-beta-galactosyltransferase activity;GO:0046872,molecular_function metal ion binding;GO:0048147,biological_process negative regulation of fibroblast proliferation;GO:0097435,biological_process fibril organization	B4GALT7; xylosylprotein 4-beta-galactosyltransferase [EC:2.4.1.133]; K00733	beta-1%2C4-galactosyltransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:930]
ENSG00000126247	378.90	395.73	363.93	383.71	392.00	370.28	0.00202156189739266	8.73888207659277	0.972775738914118	1	19:36139574-36150353:+	CAPNS1	15;GO:0004175,molecular_function endopeptidase activity;GO:0004198,molecular_function calcium-dependent cysteine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008284,biological_process positive regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016241,biological_process regulation of macroautophagy;GO:0022617,biological_process extracellular matrix disassembly;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070268,biological_process cornification	CAPNS1, CAPN4; calpain, small subunit 1; K08583	calpain small subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:1481]
ENSG00000212747	25.00	17.76	22.15	20.54	22.15	22.61	0.0188976801718396	2.91870147949867	0.973001601514296	1	X:135020503-135022529:-	RTL8B	1;GO:0005515,molecular_function protein binding	NA	retrotransposon Gag like 8B [Source:HGNC Symbol%3BAcc:HGNC:33156]
ENSG00000163714	46.23	44.04	45.22	44.27	47.15	45.43	-0.00197277482092727	7.16872312367004	0.973039223586097	1	3:142964496-143060546:+	U2SURP	7;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006396,biological_process RNA processing	SR140; U2-associated protein SR140; K12842	U2 snRNP associated SURP domain containing [Source:HGNC Symbol%3BAcc:HGNC:30855]
ENSG00000102096	9.08	9.32	8.36	9.55	8.05	9.50	-0.0113544374342079	3.09190155066472	0.973067124385924	1	X:48913181-48919024:-	PIM2	27;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007140,biological_process male meiosis;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008637,biological_process apoptotic mitochondrial changes;GO:0009615,biological_process response to virus;GO:0010508,biological_process positive regulation of autophagy;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0032091,biological_process negative regulation of protein binding;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046777,biological_process protein autophosphorylation;GO:0050821,biological_process protein stabilization	PIM2; proto-oncogene serine/threonine-protein kinase Pim-2 [EC:2.7.11.1]; K08806	Pim-2 proto-oncogene%2C serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:8987]
ENSG00000137154	2066.97	1934.93	1989.07	2063.31	1909.05	2076.46	-0.00203903337944899	10.7904580755895	0.97309351858978	1	9:19375714-19380254:-	RPS6	41;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000278,biological_process mitotic cell cycle;GO:0001890,biological_process placenta development;GO:0002309,biological_process T cell proliferation involved in immune response;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005844,cellular_component polysome;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0006924,biological_process activation-induced cell death of T cells;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007369,biological_process gastrulation;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0019901,molecular_function protein kinase binding;GO:0022605,biological_process oogenesis stage;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030425,cellular_component dendrite;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031929,biological_process TOR signaling;GO:0033077,biological_process T cell differentiation in thymus;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0042593,biological_process glucose homeostasis;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0044297,cellular_component cell body;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048821,biological_process erythrocyte development	NA	ribosomal protein S6 [Source:HGNC Symbol%3BAcc:HGNC:10429]
ENSG00000173611	3.20	3.76	2.82	2.68	3.36	3.83	-0.0153525088740522	2.72888452104521	0.973222651839004	1	9:124942607-125143506:-	SCAI	14;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030336,biological_process negative regulation of cell migration;GO:0031965,cellular_component nuclear membrane;GO:0035024,biological_process negative regulation of Rho protein signal transduction;GO:1903507,biological_process negative regulation of nucleic acid-templated transcription	NA	suppressor of cancer cell invasion [Source:HGNC Symbol%3BAcc:HGNC:26709]
ENSG00000169239	5.77	3.02	4.43	5.65	3.10	4.81	-0.00866986867439876	2.19791007008545	0.973362447832652	1	X:15688829-15788409:+	CA5B	8;GO:0004089,molecular_function carbonate dehydratase activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006730,biological_process one-carbon metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0015701,biological_process bicarbonate transport;GO:0016829,molecular_function lyase activity;GO:0046872,molecular_function metal ion binding	CA; carbonic anhydrase [EC:4.2.1.1]; K01672	carbonic anhydrase 5B [Source:HGNC Symbol%3BAcc:HGNC:1378]
ENSG00000171865	21.35	22.34	16.43	18.72	18.43	23.14	0.00097255011900806	4.12025679317381	0.973406670726886	1	2:3544792-3558616:-	RNASEH1	16;GO:0000287,molecular_function magnesium ion binding;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0004518,molecular_function nuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0004523,molecular_function RNA-DNA hybrid ribonuclease activity;GO:0004540,molecular_function ribonuclease activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006401,biological_process RNA catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0043137,biological_process DNA replication, removal of RNA primer;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]; K03469	ribonuclease H1 [Source:HGNC Symbol%3BAcc:HGNC:18466]
ENSG00000172062	5.72	7.74	4.68	6.14	6.61	5.26	0.00491118136953941	2.57712915347316	0.973419092923774	1	5:70925029-70953942:+	SMN1	23;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006353,biological_process DNA-templated transcription, termination;GO:0006397,biological_process mRNA processing;GO:0007399,biological_process nervous system development;GO:0008380,biological_process RNA splicing;GO:0015030,cellular_component Cajal body;GO:0030018,cellular_component Z disc;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0036464,cellular_component cytoplasmic ribonucleoprotein granule;GO:0042802,molecular_function identical protein binding;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043204,cellular_component perikaryon;GO:0051170,biological_process nuclear import;GO:0097504,cellular_component Gemini of coiled bodies	SMN; survival motor neuron protein; K13129	survival of motor neuron 1%2C telomeric [Source:HGNC Symbol%3BAcc:HGNC:11117]
ENSG00000205937	113.19	105.47	107.86	107.21	109.60	113.05	-0.00198181609260555	6.75356294309604	0.973577673446617	1	16:2253115-2268412:-	RNPS1	23;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006369,biological_process termination of RNA polymerase II transcription;GO:0006397,biological_process mRNA processing;GO:0006405,biological_process RNA export from nucleus;GO:0006406,biological_process mRNA export from nucleus;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0031124,biological_process mRNA 3'-end processing;GO:0035145,cellular_component exon-exon junction complex;GO:0043065,biological_process positive regulation of apoptotic process;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0061574,cellular_component ASAP complex	RNPS1; RNA-binding protein with serine-rich domain 1; K14325	RNA binding protein with serine rich domain 1 [Source:HGNC Symbol%3BAcc:HGNC:10080]
ENSG00000101546	18.26	22.20	23.60	21.76	21.74	20.84	0.00208304065327234	4.46926187757075	0.973872399591585	1	18:80034357-80046397:+	RBFA	6;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005739,cellular_component mitochondrion;GO:0006364,biological_process rRNA processing;GO:0008150,biological_process biological_process	NA	ribosome binding factor A (putative) [Source:HGNC Symbol%3BAcc:HGNC:26120]
ENSG00000143387	6.37	6.24	5.56	5.79	5.15	7.49	-0.0139160846991354	2.861300847947	0.974177346729769	1	1:150796207-150808323:-	CTSK	27;GO:0001957,biological_process intramembranous ossification;GO:0001968,molecular_function fibronectin binding;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005518,molecular_function collagen binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030574,biological_process collagen catabolic process;GO:0036021,cellular_component endolysosome lumen;GO:0043202,cellular_component lysosomal lumen;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043394,molecular_function proteoglycan binding;GO:0045453,biological_process bone resorption;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:1903146,biological_process regulation of mitophagy;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	CTSK; cathepsin K [EC:3.4.22.38]; K01371	cathepsin K [Source:HGNC Symbol%3BAcc:HGNC:2536]
ENSG00000131187	5.17	4.92	4.35	4.95	5.10	4.42	0.00939162824672097	3.175608902616	0.974424532293883	1	5:177402139-177409576:-	F12	27;GO:0002353,biological_process plasma kallikrein-kinin cascade;GO:0002542,biological_process Factor XII activation;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0007596,biological_process blood coagulation;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0007599,biological_process hemostasis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0010756,biological_process positive regulation of plasminogen activation;GO:0016485,biological_process protein processing;GO:0016540,biological_process protein autoprocessing;GO:0016787,molecular_function hydrolase activity;GO:0030193,biological_process regulation of blood coagulation;GO:0030194,biological_process positive regulation of blood coagulation;GO:0031638,biological_process zymogen activation;GO:0042730,biological_process fibrinolysis;GO:0045087,biological_process innate immune response;GO:0051787,molecular_function misfolded protein binding;GO:0051788,biological_process response to misfolded protein;GO:0051919,biological_process positive regulation of fibrinolysis;GO:0070062,cellular_component extracellular exosome	F12; coagulation factor XII (Hageman factor) [EC:3.4.21.38]; K01328	coagulation factor XII [Source:HGNC Symbol%3BAcc:HGNC:3530]
ENSG00000166833	13.32	12.08	13.60	14.35	11.74	13.17	0.00368809816377436	6.63102458524263	0.974448912042532	1	11:19350723-20121598:+	NAV2	18;GO:0000166,molecular_function nucleotide binding;GO:0003025,biological_process regulation of systemic arterial blood pressure by baroreceptor feedback;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005614,cellular_component interstitial matrix;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007399,biological_process nervous system development;GO:0007605,biological_process sensory perception of sound;GO:0007608,biological_process sensory perception of smell;GO:0007626,biological_process locomotory behavior;GO:0008201,molecular_function heparin binding;GO:0016787,molecular_function hydrolase activity;GO:0021554,biological_process optic nerve development;GO:0021563,biological_process glossopharyngeal nerve development;GO:0021564,biological_process vagus nerve development	NA	neuron navigator 2 [Source:HGNC Symbol%3BAcc:HGNC:15997]
ENSG00000139517	3.75	3.37	3.70	3.29	3.15	4.42	0.00793956180246575	2.93855850308856	0.974519637928188	1	13:27545910-27620404:-	LNX2	4;GO:0005515,molecular_function protein binding;GO:0030165,molecular_function PDZ domain binding;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization	NA	ligand of numb-protein X 2 [Source:HGNC Symbol%3BAcc:HGNC:20421]
ENSG00000089063	75.81	90.84	90.13	88.83	89.34	79.95	0.00210613494393716	5.92787998629509	0.974879322695537	1	20:5068231-5113103:-	TMEM230	15;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005776,cellular_component autophagosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0045202,cellular_component synapse;GO:0048489,biological_process synaptic vesicle transport;GO:0055037,cellular_component recycling endosome	NA	transmembrane protein 230 [Source:HGNC Symbol%3BAcc:HGNC:15876]
ENSG00000163006	4.84	4.88	4.45	4.92	4.52	4.79	0.00332461151548498	3.34507911064272	0.974893330588769	1	2:108786756-108885477:+	CCDC138	NA	NA	coiled-coil domain containing 138 [Source:HGNC Symbol%3BAcc:HGNC:26531]
ENSG00000135940	183.59	173.85	169.26	172.77	177.16	180.25	0.00279963969584451	6.09543010365777	0.974899856661545	1	2:97646039-97648383:+	COX5B	12;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005740,cellular_component mitochondrial envelope;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005751,cellular_component mitochondrial respiratory chain complex IV;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0007585,biological_process respiratory gaseous exchange;GO:0016020,cellular_component membrane;GO:0042776,biological_process mitochondrial ATP synthesis coupled proton transport;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	COX5B; cytochrome c oxidase subunit 5b; K02265	cytochrome c oxidase subunit 5B [Source:HGNC Symbol%3BAcc:HGNC:2269]
ENSG00000114923	2.14	2.12	2.18	2.46	2.21	1.87	-0.00668826639259109	3.14487382452487	0.974992128792852	1	2:219627326-219641980:+	SLC4A3	19;GO:0005215,molecular_function transporter activity;GO:0005452,molecular_function inorganic anion exchanger activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006820,biological_process anion transport;GO:0008509,molecular_function anion transmembrane transporter activity;GO:0008510,molecular_function sodium:bicarbonate symporter activity;GO:0015297,molecular_function antiporter activity;GO:0015301,molecular_function anion:anion antiporter activity;GO:0015698,biological_process inorganic anion transport;GO:0015701,biological_process bicarbonate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	solute carrier family 4 member 3 [Source:HGNC Symbol%3BAcc:HGNC:11029]
ENSG00000144867	30.14	34.79	30.51	31.68	29.48	35.12	-0.00827224371857589	4.70616405802187	0.97532984688737	1	3:133784032-133825772:+	SRPRB	13;GO:0000166,molecular_function nucleotide binding;GO:0005047,molecular_function signal recognition particle binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005785,cellular_component signal recognition particle receptor complex;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005881,cellular_component cytoplasmic microtubule;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0036498,biological_process IRE1-mediated unfolded protein response	SRPRB, SRP102; signal recognition particle receptor subunit beta; K12272	SRP receptor beta subunit [Source:HGNC Symbol%3BAcc:HGNC:24085]
ENSG00000114648	5.59	4.93	5.99	5.59	5.36	5.84	-0.00428560514205029	3.33390082284273	0.975589387871213	1	3:47282916-47346816:+	KLHL18	4;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	kelch like family member 18 [Source:HGNC Symbol%3BAcc:HGNC:29120]
ENSG00000110880	65.29	72.14	66.55	67.13	71.06	66.99	0.00145702608726248	6.76001226508216	0.975917119724203	1	12:108645108-108731596:-	CORO1C	33;GO:0001755,biological_process neural crest cell migration;GO:0001932,biological_process regulation of protein phosphorylation;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006909,biological_process phagocytosis;GO:0007165,biological_process signal transduction;GO:0010632,biological_process regulation of epithelial cell migration;GO:0010633,biological_process negative regulation of epithelial cell migration;GO:0010762,biological_process regulation of fibroblast migration;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016600,cellular_component flotillin complex;GO:0030027,cellular_component lamellipodium;GO:0030036,biological_process actin cytoskeleton organization;GO:0031982,cellular_component vesicle;GO:0042995,cellular_component cell projection;GO:0044387,biological_process negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045184,biological_process establishment of protein localization;GO:0048365,molecular_function Rac GTPase binding;GO:0051015,molecular_function actin filament binding;GO:0051893,biological_process regulation of focal adhesion assembly;GO:0051895,biological_process negative regulation of focal adhesion assembly;GO:0090630,biological_process activation of GTPase activity;GO:1900024,biological_process regulation of substrate adhesion-dependent cell spreading;GO:1900025,biological_process negative regulation of substrate adhesion-dependent cell spreading;GO:1900027,biological_process regulation of ruffle assembly;GO:2000394,biological_process positive regulation of lamellipodium morphogenesis	NA	coronin 1C [Source:HGNC Symbol%3BAcc:HGNC:2254]
ENSG00000079313	10.85	11.55	11.62	11.20	12.00	11.16	-0.00360824216078086	5.41250430147851	0.976177977900925	1	19:1815245-1848463:-	REXO1	8;GO:0003676,molecular_function nucleic acid binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0016604,cellular_component nuclear body;GO:0016787,molecular_function hydrolase activity;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	REX1, REXO1, RNH70; RNA exonuclease 1 [EC:3.1.-.-]; K14570	RNA exonuclease 1 homolog [Source:HGNC Symbol%3BAcc:HGNC:24616]
ENSG00000178922	40.22	38.47	37.43	39.57	35.53	42.22	-0.00370403400367968	5.29062425579065	0.97619949334937	1	1:43451002-43453989:-	HYI	6;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0008903,molecular_function hydroxypyruvate isomerase activity;GO:0016853,molecular_function isomerase activity	hyi, gip; hydroxypyruvate isomerase [EC:5.3.1.22]; K01816	hydroxypyruvate isomerase (putative) [Source:HGNC Symbol%3BAcc:HGNC:26948]
ENSG00000173113	188.29	205.67	184.88	184.96	203.55	193.72	0.00141544493950236	6.61569773202508	0.976276268440711	1	11:64316459-64318084:-	TRMT112	12;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006415,biological_process translational termination;GO:0008276,molecular_function protein methyltransferase activity;GO:0018364,biological_process peptidyl-glutamine methylation;GO:0030488,biological_process tRNA methylation;GO:0031167,biological_process rRNA methylation;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex;GO:0070062,cellular_component extracellular exosome;GO:0070476,biological_process rRNA (guanine-N7)-methylation	NA	tRNA methyltransferase subunit 11-2 [Source:HGNC Symbol%3BAcc:HGNC:26940]
ENSG00000105755	9.16	7.73	9.14	10.79	7.90	7.80	-0.00410161422432029	3.01368106247686	0.976388488894335	1	19:43506718-43527244:-	ETHE1	14;GO:0005506,molecular_function iron ion binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006749,biological_process glutathione metabolic process;GO:0016491,molecular_function oxidoreductase activity;GO:0046872,molecular_function metal ion binding;GO:0050313,molecular_function sulfur dioxygenase activity;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0070221,biological_process sulfide oxidation, using sulfide:quinone oxidoreductase;GO:0070813,biological_process hydrogen sulfide metabolic process	NA	ETHE1%2C persulfide dioxygenase [Source:HGNC Symbol%3BAcc:HGNC:23287]
ENSG00000104983	5.61	5.23	5.89	5.07	6.72	4.99	0.0149008577685629	3.12763285902375	0.976441710431151	1	19:45995460-46021318:+	CCDC61	1;GO:0005813,cellular_component centrosome	NA	coiled-coil domain containing 61 [Source:HGNC Symbol%3BAcc:HGNC:33629]
ENSG00000152128	11.97	8.93	10.61	11.31	9.71	10.71	0.0146099734221826	3.22416296716925	0.976478428910332	1	2:134455758-134719000:-	TMEM163	10;GO:0005768,cellular_component endosome;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030285,cellular_component integral component of synaptic vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0045202,cellular_component synapse	NA	transmembrane protein 163 [Source:HGNC Symbol%3BAcc:HGNC:25380]
ENSG00000180035	6.02	5.57	6.43	6.14	5.93	6.03	0.0116044438819813	3.50353520732082	0.97659248489612	1	16:30378105-30400108:+	ZNF48	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 48 [Source:HGNC Symbol%3BAcc:HGNC:13114]
ENSG00000077380	74.93	82.70	74.20	74.11	82.97	76.93	-0.00297289084135641	7.25713891667607	0.976721947429049	1	2:171687408-171748420:+	DYNC1I2	25;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0005874,cellular_component microtubule;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007018,biological_process microtubule-based movement;GO:0007062,biological_process sister chromatid cohesion;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0010970,biological_process establishment of localization by movement along microtubule;GO:0016032,biological_process viral process;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030286,cellular_component dynein complex;GO:0031982,cellular_component vesicle;GO:0045503,molecular_function dynein light chain binding;GO:0045504,molecular_function dynein heavy chain binding;GO:0097711,biological_process ciliary basal body-plasma membrane docking;GO:2000582,biological_process positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	DYNC1I, DNCI; dynein intermediate chain, cytosolic; K10415	dynein cytoplasmic 1 intermediate chain 2 [Source:HGNC Symbol%3BAcc:HGNC:2964]
ENSG00000132382	15.23	16.99	14.84	16.31	16.16	15.00	-0.00426773523108427	5.98643921181487	0.976789370725571	1	17:4538896-4555631:-	MYBBP1A	29;GO:0001047,molecular_function core promoter binding;GO:0001649,biological_process osteoblast differentiation;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006913,biological_process nucleocytoplasmic transport;GO:0008134,molecular_function transcription factor binding;GO:0016020,cellular_component membrane;GO:0022904,biological_process respiratory electron transport chain;GO:0032922,biological_process circadian regulation of gene expression;GO:0042149,biological_process cellular response to glucose starvation;GO:0042564,cellular_component NLS-dependent protein nuclear import complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0071158,biological_process positive regulation of cell cycle arrest;GO:0071897,biological_process DNA biosynthetic process;GO:0072332,biological_process intrinsic apoptotic signaling pathway by p53 class mediator;GO:2000210,biological_process positive regulation of anoikis	NA	MYB binding protein 1a [Source:HGNC Symbol%3BAcc:HGNC:7546]
ENSG00000197019	11.47	10.93	11.95	10.58	9.86	14.40	-0.00884311377120586	3.06177183270754	0.976828459404495	1	19:40421591-40426025:-	SERTAD1	10;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008284,biological_process positive regulation of cell proliferation;GO:0030308,biological_process negative regulation of cell growth;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	SERTA domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17932]
ENSG00000140563	8.87	6.62	8.97	8.59	7.61	8.62	-0.000414910138301614	4.5261690968992	0.976948847154415	1	15:94231537-94483952:+	MCTP2	8;GO:0005509,molecular_function calcium ion binding;GO:0005654,cellular_component nucleoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0007275,biological_process multicellular organism development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019722,biological_process calcium-mediated signaling	NA	multiple C2 and transmembrane domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:25636]
ENSG00000119669	31.05	27.49	32.33	30.88	28.49	32.51	-0.00139635081062072	6.19030022560982	0.977020704805653	1	14:77024542-77028699:-	IRF2BPL	8;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003674,molecular_function molecular_function;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046543,biological_process development of secondary female sexual characteristics;GO:0046872,molecular_function metal ion binding	NA	interferon regulatory factor 2 binding protein like [Source:HGNC Symbol%3BAcc:HGNC:14282]
ENSG00000251369	7.46	6.94	7.51	7.86	6.38	7.99	-0.00620537355549809	3.38065915613155	0.977137509616489	1	19:57535256-57559863:-	ZNF550	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 550 [Source:HGNC Symbol%3BAcc:HGNC:28643]
ENSG00000167840	7.70	8.32	7.67	8.47	7.85	7.61	-0.00784949301997038	3.55025135392806	0.977168869075619	1	17:5105540-5123116:-	ZNF232	10;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 232 [Source:HGNC Symbol%3BAcc:HGNC:13026]
ENSG00000188290	13.25	12.51	14.50	12.33	13.00	15.56	-0.00820002514810063	3.35193586479794	0.977403113245884	1	1:998961-1000172:-	HES4	9;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0008134,molecular_function transcription factor binding;GO:0030154,biological_process cell differentiation;GO:0046983,molecular_function protein dimerization activity	HES4; hairy and enhancer of split 4; K09089	hes family bHLH transcription factor 4 [Source:HGNC Symbol%3BAcc:HGNC:24149]
ENSG00000101871	9.59	9.48	8.91	8.22	11.42	8.69	-0.00505390667420347	4.48970379272826	0.977415909854888	1	X:10445309-10833654:-	MID1	27;GO:0000226,biological_process microtubule cytoskeleton organization;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005875,cellular_component microtubule associated complex;GO:0005881,cellular_component cytoplasmic microtubule;GO:0007026,biological_process negative regulation of microtubule depolymerization;GO:0007389,biological_process pattern specification process;GO:0008017,molecular_function microtubule binding;GO:0008270,molecular_function zinc ion binding;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032874,biological_process positive regulation of stress-activated MAPK cascade;GO:0035372,biological_process protein localization to microtubule;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051219,molecular_function phosphoprotein binding;GO:0060333,biological_process interferon-gamma-mediated signaling pathway	TRIM18, MID1; midline 1 [EC:2.3.2.27]; K08285	midline 1 [Source:HGNC Symbol%3BAcc:HGNC:7095]
ENSG00000144744	60.68	56.63	58.56	57.74	61.85	58.09	-0.00144517594027177	6.48104966992463	0.977458486823859	1	3:69054729-69080408:-	UBA3	24;GO:0000166,molecular_function nucleotide binding;GO:0000278,biological_process mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0006508,biological_process proteolysis;GO:0007049,biological_process cell cycle;GO:0007113,biological_process endomitotic cell cycle;GO:0008641,molecular_function small protein activating enzyme activity;GO:0016874,molecular_function ligase activity;GO:0016881,molecular_function acid-amino acid ligase activity;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0019781,molecular_function NEDD8 activating enzyme activity;GO:0019788,molecular_function NEDD8 transferase activity;GO:0038061,biological_process NIK/NF-kappaB signaling;GO:0042802,molecular_function identical protein binding;GO:0043687,biological_process post-translational protein modification;GO:0045116,biological_process protein neddylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0051726,biological_process regulation of cell cycle	UBE1C, UBA3; ubiquitin-activating enzyme E1 C [EC:6.2.1.45]; K10686	ubiquitin like modifier activating enzyme 3 [Source:HGNC Symbol%3BAcc:HGNC:12470]
ENSG00000085788	16.22	15.54	16.38	16.49	14.78	17.17	0.00359816690423016	5.11076833564371	0.977509977292177	1	8:38225217-38275558:+	DDHD2	20;GO:0004620,molecular_function phospholipase activity;GO:0004806,molecular_function triglyceride lipase activity;GO:0005737,cellular_component cytoplasm;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007626,biological_process locomotory behavior;GO:0008542,biological_process visual learning;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019433,biological_process triglyceride catabolic process;GO:0030134,cellular_component ER to Golgi transport vesicle;GO:0034389,biological_process lipid particle organization;GO:0046872,molecular_function metal ion binding;GO:0090141,biological_process positive regulation of mitochondrial fission	NA	DDHD domain containing 2 [Source:HGNC Symbol%3BAcc:HGNC:29106]
ENSG00000135334	69.00	59.94	70.58	69.71	65.01	66.39	0.00594992022249808	5.35438455887468	0.977605857892502	1	6:87675071-87702209:-	AKIRIN2	19;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002376,biological_process immune system process;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0008284,biological_process positive regulation of cell proliferation;GO:0009790,biological_process embryo development;GO:0010629,biological_process negative regulation of gene expression;GO:0010950,biological_process positive regulation of endopeptidase activity;GO:0017053,cellular_component transcriptional repressor complex;GO:0019899,molecular_function enzyme binding;GO:0032496,biological_process response to lipopolysaccharide;GO:0032755,biological_process positive regulation of interleukin-6 production;GO:0045087,biological_process innate immune response;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	akirin 2 [Source:HGNC Symbol%3BAcc:HGNC:21407]
ENSG00000110660	32.98	31.00	28.34	32.03	31.63	29.64	-0.00282947925566647	5.12441696337934	0.977670538243956	1	11:107790990-107928293:-	SLC35F2	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0006810,biological_process transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	solute carrier family 35 member F2 [Source:HGNC Symbol%3BAcc:HGNC:23615]
ENSG00000130589	3.92	3.77	3.54	3.76	3.27	4.31	-0.00496674584184455	4.91417000162458	0.977766964466483	1	20:63558085-63574239:-	HELZ2	17;GO:0000166,molecular_function nucleotide binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019216,biological_process regulation of lipid metabolic process;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	helicase with zinc finger 2 [Source:HGNC Symbol%3BAcc:HGNC:30021]
ENSG00000100241	18.62	19.06	19.26	19.20	18.74	19.54	-0.0023227066663021	6.76251733314807	0.97778599154248	1	22:50444999-50475024:-	SBF1	14;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005634,cellular_component nucleus;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0007283,biological_process spermatogenesis;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016021,cellular_component integral component of membrane;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0019208,molecular_function phosphatase regulator activity;GO:0043087,biological_process regulation of GTPase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0061024,biological_process membrane organization	NA	SET binding factor 1 [Source:HGNC Symbol%3BAcc:HGNC:10542]
ENSG00000163545	5.85	6.26	5.66	6.13	6.24	5.58	-0.00716038860294605	3.60109824879375	0.977804887191705	1	1:205302058-205321791:-	NUAK2	19;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0030036,biological_process actin cytoskeleton organization;GO:0035556,biological_process intracellular signal transduction;GO:0042149,biological_process cellular response to glucose starvation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding	NA	NUAK family kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:29558]
ENSG00000141736	23.46	25.34	23.00	23.68	26.17	22.38	0.001897774634231	6.57143130958276	0.977814496763505	1	17:39687913-39730426:+	ERBB2	82;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001042,molecular_function RNA polymerase I core binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0004716,molecular_function receptor signaling protein tyrosine kinase activity;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007167,biological_process enzyme linked receptor protein signaling pathway;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007399,biological_process nervous system development;GO:0007422,biological_process peripheral nervous system development;GO:0007507,biological_process heart development;GO:0007528,biological_process neuromuscular junction development;GO:0008022,molecular_function protein C-terminus binding;GO:0008045,biological_process motor neuron axon guidance;GO:0008283,biological_process cell proliferation;GO:0010008,cellular_component endosome membrane;GO:0010628,biological_process positive regulation of gene expression;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016323,cellular_component basolateral plasma membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019838,molecular_function growth factor binding;GO:0019903,molecular_function protein phosphatase binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030307,biological_process positive regulation of cell growth;GO:0031410,cellular_component cytoplasmic vesicle;GO:0032886,biological_process regulation of microtubule-based process;GO:0033088,biological_process negative regulation of immature T cell proliferation in thymus;GO:0035556,biological_process intracellular signal transduction;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042060,biological_process wound healing;GO:0042552,biological_process myelination;GO:0042802,molecular_function identical protein binding;GO:0043125,molecular_function ErbB-3 class receptor binding;GO:0043209,cellular_component myelin sheath;GO:0043235,cellular_component receptor complex;GO:0043406,biological_process positive regulation of MAP kinase activity;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045727,biological_process positive regulation of translation;GO:0045765,biological_process regulation of angiogenesis;GO:0045785,biological_process positive regulation of cell adhesion;GO:0045943,biological_process positive regulation of transcription from RNA polymerase I promoter;GO:0045945,biological_process positive regulation of transcription from RNA polymerase III promoter;GO:0046777,biological_process protein autophosphorylation;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0046982,molecular_function protein heterodimerization activity;GO:0046983,molecular_function protein dimerization activity;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0048709,biological_process oligodendrocyte differentiation;GO:0050679,biological_process positive regulation of epithelial cell proliferation;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071364,biological_process cellular response to epidermal growth factor stimulus;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1901185,biological_process negative regulation of ERBB signaling pathway;GO:2000145,biological_process regulation of cell motility	ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]; K05083	erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:3430]
ENSG00000115977	7.58	8.51	8.00	7.67	8.61	7.91	0.00128737354248405	5.07279363997669	0.978180331725681	1	2:69457996-69674349:-	AAK1	27;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005112,molecular_function Notch binding;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006468,biological_process protein phosphorylation;GO:0006897,biological_process endocytosis;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019897,cellular_component extrinsic component of plasma membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0031252,cellular_component cell leading edge;GO:0032880,biological_process regulation of protein localization;GO:0035612,molecular_function AP-2 adaptor complex binding;GO:0043195,cellular_component terminal bouton;GO:0045747,biological_process positive regulation of Notch signaling pathway;GO:0046777,biological_process protein autophosphorylation;GO:0050821,biological_process protein stabilization;GO:0061024,biological_process membrane organization;GO:2000369,biological_process regulation of clathrin-mediated endocytosis	NA	AP2 associated kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:19679]
ENSG00000256060	16.98	19.11	18.23	23.71	15.35	15.40	0.00546852458130359	2.9537452097817	0.978247461869184	1	19:57363510-57365353:+	AC003002.1	12;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0006351,biological_process transcription, DNA-templated;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016192,biological_process vesicle-mediated transport;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048471,cellular_component perinuclear region of cytoplasm	NA	Trafficking protein particle complex subunit 2B  [Source:UniProtKB/Swiss-Prot%3BAcc:P0DI82]
ENSG00000119408	121.50	116.62	125.69	123.22	121.20	122.99	-0.00147343924130726	7.08528555475382	0.978328093773111	1	9:124257605-124353307:+	NEK6	44;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0000910,biological_process cytokinesis;GO:0000922,cellular_component spindle pole;GO:0001222,molecular_function transcription corepressor binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0007165,biological_process signal transduction;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019894,molecular_function kinesin binding;GO:0019901,molecular_function protein kinase binding;GO:0030071,biological_process regulation of mitotic metaphase/anaphase transition;GO:0031572,biological_process G2 DNA damage checkpoint;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0033613,molecular_function activating transcription factor binding;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043234,cellular_component protein complex;GO:0046777,biological_process protein autophosphorylation;GO:0046872,molecular_function metal ion binding;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:2000772,biological_process regulation of cellular senescence	NA	NIMA related kinase 6 [Source:HGNC Symbol%3BAcc:HGNC:7749]
ENSG00000124942	209.10	234.44	199.98	206.66	234.56	206.66	0.00205973755527737	11.9063876724024	0.978436612846145	1	11:62433541-62556235:-	AHNAK	23;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030315,cellular_component T-tubule;GO:0031982,cellular_component vesicle;GO:0042383,cellular_component sarcolemma;GO:0043034,cellular_component costamere;GO:0043484,biological_process regulation of RNA splicing;GO:0044291,cellular_component cell-cell contact zone;GO:0044548,molecular_function S100 protein binding;GO:0045121,cellular_component membrane raft;GO:0045296,molecular_function cadherin binding;GO:0051259,biological_process protein oligomerization;GO:0070062,cellular_component extracellular exosome;GO:0097493,molecular_function structural molecule activity conferring elasticity;GO:1901385,biological_process regulation of voltage-gated calcium channel activity	NA	AHNAK nucleoprotein [Source:HGNC Symbol%3BAcc:HGNC:347]
ENSG00000159208	9.72	7.53	8.16	7.45	8.54	9.56	0.0112302697742051	3.3239507011056	0.978438633717387	1	1:150282542-150287093:+	CIART	12;GO:0000976,molecular_function transcription regulatory region sequence-specific DNA binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016605,cellular_component PML body;GO:0032922,biological_process circadian regulation of gene expression;GO:0045475,biological_process locomotor rhythm;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0048511,biological_process rhythmic process;GO:0070888,molecular_function E-box binding	NA	circadian associated repressor of transcription [Source:HGNC Symbol%3BAcc:HGNC:25200]
ENSG00000104147	15.52	15.16	14.14	12.75	17.22	15.46	-0.00801786155584622	3.39082837176574	0.978448239728382	1	15:41309267-41332621:-	OIP5	17;GO:0000775,cellular_component chromosome, centromeric region;GO:0000785,cellular_component chromatin;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007059,biological_process chromosome segregation;GO:0007154,biological_process cell communication;GO:0010369,cellular_component chromocenter;GO:0015030,cellular_component Cajal body;GO:0016607,cellular_component nuclear speck;GO:0034080,biological_process CENP-A containing nucleosome assembly;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0051301,biological_process cell division	NA	Opa interacting protein 5 [Source:HGNC Symbol%3BAcc:HGNC:20300]
ENSG00000057663	59.87	59.01	62.30	61.61	59.55	61.27	0.00295342001546824	5.6873507021951	0.978666247110477	1	6:106045422-106325791:-	ATG5	49;GO:0000045,biological_process autophagosome assembly;GO:0000422,biological_process mitophagy;GO:0001974,biological_process blood vessel remodeling;GO:0002376,biological_process immune system process;GO:0002739,biological_process regulation of cytokine secretion involved in immune response;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005776,cellular_component autophagosome;GO:0005829,cellular_component cytosol;GO:0005930,cellular_component axoneme;GO:0006501,biological_process C-terminal protein lipidation;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0006995,biological_process cellular response to nitrogen starvation;GO:0009267,biological_process cellular response to starvation;GO:0009620,biological_process response to fungus;GO:0016020,cellular_component membrane;GO:0016236,biological_process macroautophagy;GO:0019725,biological_process cellular homeostasis;GO:0019776,molecular_function Atg8 ligase activity;GO:0019883,biological_process antigen processing and presentation of endogenous antigen;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0034045,cellular_component pre-autophagosomal structure membrane;GO:0034274,cellular_component Atg12-Atg5-Atg16 complex;GO:0035973,biological_process aggrephagy;GO:0039689,biological_process negative stranded viral RNA replication;GO:0042311,biological_process vasodilation;GO:0042493,biological_process response to drug;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043687,biological_process post-translational protein modification;GO:0044233,cellular_component ER-mitochondrion membrane contact site;GO:0044804,biological_process nucleophagy;GO:0045060,biological_process negative thymic T cell selection;GO:0045087,biological_process innate immune response;GO:0048840,biological_process otolith development;GO:0050765,biological_process negative regulation of phagocytosis;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0055015,biological_process ventricular cardiac muscle cell development;GO:0060047,biological_process heart contraction;GO:0060548,biological_process negative regulation of cell death;GO:0061739,biological_process protein lipidation involved in autophagosome assembly;GO:0070257,biological_process positive regulation of mucus secretion;GO:0071500,biological_process cellular response to nitrosative stress;GO:0075044,biological_process autophagy of host cells involved in interaction with symbiont;GO:1902017,biological_process regulation of cilium assembly;GO:2000377,biological_process regulation of reactive oxygen species metabolic process;GO:2000378,biological_process negative regulation of reactive oxygen species metabolic process;GO:2000619,biological_process negative regulation of histone H4-K16 acetylation	ATG5; autophagy-related protein 5; K08339	autophagy related 5 [Source:HGNC Symbol%3BAcc:HGNC:589]
ENSG00000068745	51.36	54.44	55.69	51.07	56.39	55.09	0.00181796952489444	6.68622232133606	0.978667698825853	1	3:48688002-48740353:-	IP6K2	24;GO:0000166,molecular_function nucleotide binding;GO:0000827,molecular_function inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828,molecular_function inositol hexakisphosphate kinase activity;GO:0000829,molecular_function inositol heptakisphosphate kinase activity;GO:0000832,molecular_function inositol hexakisphosphate 5-kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006817,biological_process phosphate ion transport;GO:0008440,molecular_function inositol-1,4,5-trisphosphate 3-kinase activity;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0030308,biological_process negative regulation of cell growth;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043647,biological_process inositol phosphate metabolic process;GO:0045111,cellular_component intermediate filament cytoskeleton;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0052723,molecular_function inositol hexakisphosphate 1-kinase activity;GO:0052724,molecular_function inositol hexakisphosphate 3-kinase activity;GO:0052836,molecular_function inositol 5-diphosphate pentakisphosphate 5-kinase activity;GO:0052839,molecular_function inositol diphosphate tetrakisphosphate kinase activity;GO:0060337,biological_process type I interferon signaling pathway	IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]; K07756	inositol hexakisphosphate kinase 2 [Source:HGNC Symbol%3BAcc:HGNC:17313]
ENSG00000111845	23.54	23.89	26.41	25.21	23.86	25.23	0.00382246246661513	4.86902717944819	0.978796856748269	1	6:10694694-10709782:+	PAK1IP1	9;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0008283,biological_process cell proliferation;GO:0009968,biological_process negative regulation of signal transduction;GO:0042254,biological_process ribosome biogenesis;GO:0042273,biological_process ribosomal large subunit biogenesis;GO:0060021,biological_process palate development;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	NA	PAK1 interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:20882]
ENSG00000022277	75.81	85.42	74.77	79.77	81.64	75.90	0.000952686256008815	6.31535260610546	0.978807874220554	1	20:56468584-56519449:+	RTFDC1	6;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process;GO:0071171,biological_process site-specific DNA replication termination at RTS1 barrier;GO:1902979,biological_process mitotic DNA replication termination	NA	replication termination factor 2 domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:15890]
ENSG00000001461	8.13	6.83	8.12	8.67	7.31	7.27	0.0107392255031765	3.50142941644506	0.978876901637824	1	1:24415793-24472976:+	NIPAL3	6;GO:0005515,molecular_function protein binding;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0015693,biological_process magnesium ion transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1903830,biological_process magnesium ion transmembrane transport	NA	NIPA like domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:25233]
ENSG00000183762	9.37	8.88	9.02	9.48	9.50	8.48	0.00610462174147144	3.7768098071335	0.979187639368146	1	22:29073077-29168333:+	KREMEN1	11;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0007154,biological_process cell communication;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0030279,biological_process negative regulation of ossification;GO:0060173,biological_process limb development;GO:0060828,biological_process regulation of canonical Wnt signaling pathway;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway	NA	kringle containing transmembrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17550]
ENSG00000171017	14.17	12.85	13.59	15.18	11.97	13.72	0.00475385367839168	5.02846975607418	0.9791904622161	1	19:7888504-7902021:+	LRRC8E	16;GO:0005225,molecular_function volume-sensitive anion channel activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034702,cellular_component ion channel complex;GO:0044070,biological_process regulation of anion transport;GO:0055085,biological_process transmembrane transport;GO:0098656,biological_process anion transmembrane transport	NA	leucine rich repeat containing 8 family member E [Source:HGNC Symbol%3BAcc:HGNC:26272]
ENSG00000140199	3.12	3.19	3.23	2.75	3.16	3.66	0.0053427141829727	3.53891517550439	0.979327002751961	1	15:34229995-34338060:-	SLC12A6	19;GO:0001525,biological_process angiogenesis;GO:0005215,molecular_function transporter activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0007268,biological_process chemical synaptic transmission;GO:0015293,molecular_function symporter activity;GO:0015377,molecular_function cation:chloride symporter activity;GO:0015379,molecular_function potassium:chloride symporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0022820,molecular_function potassium ion symporter activity;GO:0055085,biological_process transmembrane transport;GO:0071477,biological_process cellular hypotonic salinity response;GO:0071805,biological_process potassium ion transmembrane transport;GO:1902476,biological_process chloride transmembrane transport	NA	solute carrier family 12 member 6 [Source:HGNC Symbol%3BAcc:HGNC:10914]
ENSG00000276045	14.92	12.09	11.51	13.49	11.77	13.76	-0.00254484757122007	3.46191436597959	0.979382134676475	1	12:121626549-121642677:+	ORAI1	7;GO:0002115,biological_process store-operated calcium entry;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0043234,cellular_component protein complex;GO:0061180,biological_process mammary gland epithelium development;GO:0070509,biological_process calcium ion import	ORAI1; calcium release-activated calcium channel protein 1; K16056	ORAI calcium release-activated calcium modulator 1 [Source:HGNC Symbol%3BAcc:HGNC:25896]
ENSG00000197705	4.08	4.92	4.72	3.93	5.60	4.23	0.00335788197603763	3.25580329460047	0.979424096015851	1	18:32672670-32773062:-	KLHL14	12;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0016235,cellular_component aggresome;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body	NA	kelch like family member 14 [Source:HGNC Symbol%3BAcc:HGNC:29266]
ENSG00000174840	7.69	7.05	6.70	6.49	7.64	7.43	0.00530090133844417	3.7519176427302	0.980030617248048	1	3:57556275-57566844:+	PDE12	10;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0004535,molecular_function poly(A)-specific ribonuclease activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006397,biological_process mRNA processing;GO:0016787,molecular_function hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090503,biological_process RNA phosphodiester bond hydrolysis, exonucleolytic	NA	phosphodiesterase 12 [Source:HGNC Symbol%3BAcc:HGNC:25386]
ENSG00000125845	11.95	9.49	10.97	11.16	10.15	11.36	0.00966734397954824	3.71126953291611	0.980137389202105	1	20:6767663-6780280:+	BMP2	109;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000187,biological_process activation of MAPK activity;GO:0001501,biological_process skeletal system development;GO:0001503,biological_process ossification;GO:0001649,biological_process osteoblast differentiation;GO:0001658,biological_process branching involved in ureteric bud morphogenesis;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0001837,biological_process epithelial to mesenchymal transition;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0002062,biological_process chondrocyte differentiation;GO:0003130,biological_process BMP signaling pathway involved in heart induction;GO:0003181,biological_process atrioventricular valve morphogenesis;GO:0003203,biological_process endocardial cushion morphogenesis;GO:0003308,biological_process negative regulation of Wnt signaling pathway involved in heart development;GO:0004745,molecular_function retinol dehydrogenase activity;GO:0005102,molecular_function receptor binding;GO:0005125,molecular_function cytokine activity;GO:0005160,molecular_function transforming growth factor beta receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006029,biological_process proteoglycan metabolic process;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006468,biological_process protein phosphorylation;GO:0006954,biological_process inflammatory response;GO:0007219,biological_process Notch signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0008083,molecular_function growth factor activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009790,biological_process embryo development;GO:0009887,biological_process organ morphogenesis;GO:0009986,cellular_component cell surface;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0010894,biological_process negative regulation of steroid biosynthetic process;GO:0010922,biological_process positive regulation of phosphatase activity;GO:0019211,molecular_function phosphatase activator activity;GO:0021537,biological_process telencephalon development;GO:0021978,biological_process telencephalon regionalization;GO:0030154,biological_process cell differentiation;GO:0030177,biological_process positive regulation of Wnt signaling pathway;GO:0030282,biological_process bone mineralization;GO:0030335,biological_process positive regulation of cell migration;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0031648,biological_process protein destabilization;GO:0032092,biological_process positive regulation of protein binding;GO:0032348,biological_process negative regulation of aldosterone biosynthetic process;GO:0033690,biological_process positive regulation of osteoblast proliferation;GO:0035051,biological_process cardiocyte differentiation;GO:0035054,biological_process embryonic heart tube anterior/posterior pattern specification;GO:0035630,biological_process bone mineralization involved in bone maturation;GO:0039706,molecular_function co-receptor binding;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042482,biological_process positive regulation of odontogenesis;GO:0042487,biological_process regulation of odontogenesis of dentin-containing tooth;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0043569,biological_process negative regulation of insulin-like growth factor receptor signaling pathway;GO:0045165,biological_process cell fate commitment;GO:0045597,biological_process positive regulation of cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045778,biological_process positive regulation of ossification;GO:0045786,biological_process negative regulation of cell cycle;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048468,biological_process cell development;GO:0048711,biological_process positive regulation of astrocyte differentiation;GO:0048762,biological_process mesenchymal cell differentiation;GO:0048839,biological_process inner ear development;GO:0051042,biological_process negative regulation of calcium-independent cell-cell adhesion;GO:0051216,biological_process cartilage development;GO:0055007,biological_process cardiac muscle cell differentiation;GO:0055008,biological_process cardiac muscle tissue morphogenesis;GO:0055114,biological_process oxidation-reduction process;GO:0060039,biological_process pericardium development;GO:0060128,biological_process corticotropin hormone secreting cell differentiation;GO:0060129,biological_process thyroid-stimulating hormone-secreting cell differentiation;GO:0060317,biological_process cardiac epithelial to mesenchymal transition;GO:0060389,biological_process pathway-restricted SMAD protein phosphorylation;GO:0060395,biological_process SMAD protein signal transduction;GO:0060485,biological_process mesenchyme development;GO:0060804,biological_process positive regulation of Wnt signaling pathway by BMP signaling pathway;GO:0061036,biological_process positive regulation of cartilage development;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0070700,molecular_function BMP receptor binding;GO:0070724,cellular_component BMP receptor complex;GO:0071363,biological_process cellular response to growth factor stimulus;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0071773,biological_process cellular response to BMP stimulus;GO:0072138,biological_process mesenchymal cell proliferation involved in ureteric bud development;GO:0090090,biological_process negative regulation of canonical Wnt signaling pathway;GO:1900745,biological_process positive regulation of p38MAPK cascade;GO:1901522,biological_process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:1902895,biological_process positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:2000065,biological_process negative regulation of cortisol biosynthetic process;GO:2000726,biological_process negative regulation of cardiac muscle cell differentiation	BMP4; bone morphogenetic protein 4; K04662	bone morphogenetic protein 2 [Source:HGNC Symbol%3BAcc:HGNC:1069]
ENSG00000105887	213.07	215.16	230.78	217.21	221.74	224.66	0.00226476791726121	6.29004756807988	0.980163770065513	1	7:135926760-135977353:-	MTPN	23;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006584,biological_process catecholamine metabolic process;GO:0008290,cellular_component F-actin capping protein complex;GO:0010557,biological_process positive regulation of macromolecule biosynthetic process;GO:0010613,biological_process positive regulation of cardiac muscle hypertrophy;GO:0016049,biological_process cell growth;GO:0016202,biological_process regulation of striated muscle tissue development;GO:0021707,biological_process cerebellar granule cell differentiation;GO:0030182,biological_process neuron differentiation;GO:0030307,biological_process positive regulation of cell growth;GO:0030424,cellular_component axon;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0043565,molecular_function sequence-specific DNA binding;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051146,biological_process striated muscle cell differentiation;GO:0051247,biological_process positive regulation of protein metabolic process;GO:0070062,cellular_component extracellular exosome;GO:0071260,biological_process cellular response to mechanical stimulus;GO:2000812,biological_process regulation of barbed-end actin filament capping	NA	myotrophin [Source:HGNC Symbol%3BAcc:HGNC:15667]
ENSG00000186951	10.88	9.66	9.28	10.49	9.94	9.75	-0.00143095171707725	3.86020656173223	0.980447012898517	1	22:46150520-46243756:+	PPARA	71;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078,molecular_function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001223,molecular_function transcription coactivator binding;GO:0001666,biological_process response to hypoxia;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0004872,molecular_function receptor activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0008144,molecular_function drug binding;GO:0008270,molecular_function zinc ion binding;GO:0008289,molecular_function lipid binding;GO:0008544,biological_process epidermis development;GO:0010468,biological_process regulation of gene expression;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010871,biological_process negative regulation of receptor biosynthetic process;GO:0010887,biological_process negative regulation of cholesterol storage;GO:0010891,biological_process negative regulation of sequestering of triglyceride;GO:0015908,biological_process fatty acid transport;GO:0019216,biological_process regulation of lipid metabolic process;GO:0019217,biological_process regulation of fatty acid metabolic process;GO:0019902,molecular_function phosphatase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032000,biological_process positive regulation of fatty acid beta-oxidation;GO:0032091,biological_process negative regulation of protein binding;GO:0032099,biological_process negative regulation of appetite;GO:0032403,molecular_function protein complex binding;GO:0032868,biological_process response to insulin;GO:0032922,biological_process circadian regulation of gene expression;GO:0035095,biological_process behavioral response to nicotine;GO:0042060,biological_process wound healing;GO:0042157,biological_process lipoprotein metabolic process;GO:0042752,biological_process regulation of circadian rhythm;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045722,biological_process positive regulation of gluconeogenesis;GO:0045776,biological_process negative regulation of blood pressure;GO:0045820,biological_process negative regulation of glycolytic process;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046321,biological_process positive regulation of fatty acid oxidation;GO:0046872,molecular_function metal ion binding;GO:0048511,biological_process rhythmic process;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051525,molecular_function NFAT protein binding;GO:0070166,biological_process enamel mineralization;GO:0072363,biological_process regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter;GO:0072366,biological_process regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter;GO:0072369,biological_process regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter;GO:0097371,molecular_function MDM2/MDM4 family protein binding;GO:1901215,biological_process negative regulation of neuron death;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:1903038,biological_process negative regulation of leukocyte cell-cell adhesion;GO:2000678,biological_process negative regulation of transcription regulatory region DNA binding	NR1C1, PPARA; peroxisome proliferator-activated receptor alpha; K07294	peroxisome proliferator activated receptor alpha [Source:HGNC Symbol%3BAcc:HGNC:9232]
ENSG00000090612	4.78	4.80	4.67	4.65	5.23	4.43	0.00520545775723401	3.86426339397717	0.980447541582799	1	12:133181408-133214831:+	ZNF268	22;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0015629,cellular_component actin cytoskeleton;GO:0030154,biological_process cell differentiation;GO:0030335,biological_process positive regulation of cell migration;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045597,biological_process positive regulation of cell differentiation;GO:0046022,biological_process positive regulation of transcription from RNA polymerase II promoter during mitosis;GO:0046872,molecular_function metal ion binding;GO:0071157,biological_process negative regulation of cell cycle arrest	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 268 [Source:HGNC Symbol%3BAcc:HGNC:13061]
ENSG00000109220	17.98	22.78	24.09	20.72	19.61	25.14	-0.00934835736583291	3.44593804066619	0.980881740420624	1	4:54009788-54064690:-	CHIC2	10;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005794,cellular_component Golgi apparatus;GO:0005798,cellular_component Golgi-associated vesicle;GO:0005886,cellular_component plasma membrane;GO:0006893,biological_process Golgi to plasma membrane transport;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0031410,cellular_component cytoplasmic vesicle	NA	cysteine rich hydrophobic domain 2 [Source:HGNC Symbol%3BAcc:HGNC:1935]
ENSG00000069943	13.91	13.66	15.83	13.72	15.12	15.08	-0.00230247235684774	4.61027071449567	0.980973951414576	1	15:55318959-55355648:+	PIGB	11;GO:0000030,molecular_function mannosyltransferase activity;GO:0004376,molecular_function glycolipid mannosyltransferase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006506,biological_process GPI anchor biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016254,biological_process preassembly of GPI anchor in ER membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0097502,biological_process mannosylation	PIGB; GPI mannosyltransferase 3 [EC:2.4.1.-]; K05286	phosphatidylinositol glycan anchor biosynthesis class B [Source:HGNC Symbol%3BAcc:HGNC:8959]
ENSG00000120688	14.21	13.05	13.05	12.41	14.52	13.59	0.00732297021191181	3.94212105491867	0.981033981664438	1	13:41061273-41084006:+	WBP4	13;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008270,molecular_function zinc ion binding;GO:0008380,biological_process RNA splicing;GO:0016607,cellular_component nuclear speck;GO:0045292,biological_process mRNA cis splicing, via spliceosome;GO:0046872,molecular_function metal ion binding;GO:0070064,molecular_function proline-rich region binding	NA	WW domain binding protein 4 [Source:HGNC Symbol%3BAcc:HGNC:12739]
ENSG00000145214	4.33	3.76	4.95	4.07	4.78	4.28	0.0109035628851787	3.66971188723273	0.981039622085931	1	4:958886-986895:-	DGKQ	52;GO:0000166,molecular_function nucleotide binding;GO:0003951,molecular_function NAD+ kinase activity;GO:0004143,molecular_function diacylglycerol kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006111,biological_process regulation of gluconeogenesis;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0007165,biological_process signal transduction;GO:0007171,biological_process activation of transmembrane receptor protein tyrosine kinase activity;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007205,biological_process protein kinase C-activating G-protein coupled receptor signaling pathway;GO:0008152,biological_process metabolic process;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0010628,biological_process positive regulation of gene expression;GO:0010629,biological_process negative regulation of gene expression;GO:0010801,biological_process negative regulation of peptidyl-threonine phosphorylation;GO:0012506,cellular_component vesicle membrane;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0019900,molecular_function kinase binding;GO:0019933,biological_process cAMP-mediated signaling;GO:0030168,biological_process platelet activation;GO:0030297,molecular_function transmembrane receptor protein tyrosine kinase activator activity;GO:0033198,biological_process response to ATP;GO:0033613,molecular_function activating transcription factor binding;GO:0035556,biological_process intracellular signal transduction;GO:0043274,molecular_function phospholipase binding;GO:0046339,biological_process diacylglycerol metabolic process;GO:0046486,biological_process glycerolipid metabolic process;GO:0046834,biological_process lipid phosphorylation;GO:0046872,molecular_function metal ion binding;GO:0050731,biological_process positive regulation of peptidyl-tyrosine phosphorylation;GO:0051591,biological_process response to cAMP;GO:0070493,biological_process thrombin receptor signaling pathway;GO:0070528,biological_process protein kinase C signaling;GO:0090181,biological_process regulation of cholesterol metabolic process;GO:1903432,biological_process regulation of TORC1 signaling;GO:2000064,biological_process regulation of cortisol biosynthetic process;GO:2000182,biological_process regulation of progesterone biosynthetic process	dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]; K00901	diacylglycerol kinase theta [Source:HGNC Symbol%3BAcc:HGNC:2856]
ENSG00000120656	73.40	68.46	72.23	77.51	66.89	72.07	-0.00164853606287489	5.12363658462104	0.981141006006736	1	1:28589322-28643085:-	TAF12	25;GO:0000124,cellular_component SAGA complex;GO:0001102,molecular_function RNA polymerase II activating transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003713,molecular_function transcription coactivator activity;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006352,biological_process DNA-templated transcription, initiation;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0017025,molecular_function TBP-class protein binding;GO:0030914,cellular_component STAGA complex;GO:0033276,cellular_component transcription factor TFTC complex;GO:0043966,biological_process histone H3 acetylation;GO:0046982,molecular_function protein heterodimerization activity;GO:0051091,biological_process positive regulation of sequence-specific DNA binding transcription factor activity;GO:0051123,biological_process RNA polymerase II transcriptional preinitiation complex assembly;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	TAF12; transcription initiation factor TFIID subunit 12; K03126	TATA-box binding protein associated factor 12 [Source:HGNC Symbol%3BAcc:HGNC:11545]
ENSG00000186908	7.51	6.03	6.60	6.43	7.24	6.64	0.00949050914814915	3.84870329707154	0.981384487941777	1	12:76763587-76853696:+	ZDHHC17	26;GO:0000139,cellular_component Golgi membrane;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0015095,molecular_function magnesium ion transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016409,molecular_function palmitoyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0018345,biological_process protein palmitoylation;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0030054,cellular_component cell junction;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0030660,cellular_component Golgi-associated vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042734,cellular_component presynaptic membrane;GO:0042802,molecular_function identical protein binding;GO:0042953,biological_process lipoprotein transport;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045202,cellular_component synapse;GO:1903830,biological_process magnesium ion transmembrane transport	NA	zinc finger DHHC-type containing 17 [Source:HGNC Symbol%3BAcc:HGNC:18412]
ENSG00000002822	12.29	13.61	13.14	14.08	11.68	13.48	0.00120449479564424	4.99671353250484	0.981392768172798	1	7:1815792-2233243:-	MAD1L1	26;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000922,cellular_component spindle pole;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0007049,biological_process cell cycle;GO:0007062,biological_process sister chromatid cohesion;GO:0007093,biological_process mitotic cell cycle checkpoint;GO:0007094,biological_process mitotic spindle assembly checkpoint;GO:0015629,cellular_component actin cytoskeleton;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0048538,biological_process thymus development;GO:0051301,biological_process cell division;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore;GO:0072686,cellular_component mitotic spindle;GO:0090235,biological_process regulation of metaphase plate congression;GO:1901990,biological_process regulation of mitotic cell cycle phase transition	NA	MAD1 mitotic arrest deficient like 1 [Source:HGNC Symbol%3BAcc:HGNC:6762]
ENSG00000100941	83.84	80.89	86.26	77.97	85.99	89.46	-0.00158749390866168	7.51686606750943	0.981685378302871	1	14:39175182-39183218:+	PNN	20;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005198,molecular_function structural molecule activity;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0005882,cellular_component intermediate filament;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006397,biological_process mRNA processing;GO:0007155,biological_process cell adhesion;GO:0008380,biological_process RNA splicing;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0030054,cellular_component cell junction;GO:0030057,cellular_component desmosome;GO:0035145,cellular_component exon-exon junction complex;GO:0071013,cellular_component catalytic step 2 spliceosome	PNN; pinin; K13114	pinin%2C desmosome associated protein [Source:HGNC Symbol%3BAcc:HGNC:9162]
ENSG00000089234	8.55	8.61	9.24	8.90	7.99	9.66	0.00328416394921335	3.986297554039	0.981786864057313	1	12:111642145-111685986:-	BRAP	17;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000165,biological_process MAPK cascade;GO:0003676,molecular_function nucleic acid binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007265,biological_process Ras protein signal transduction;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008270,molecular_function zinc ion binding;GO:0009968,biological_process negative regulation of signal transduction;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031965,cellular_component nuclear membrane;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	BRAP; BRCA1-associated protein [EC:2.3.2.27]; K10632	BRCA1 associated protein [Source:HGNC Symbol%3BAcc:HGNC:1099]
ENSG00000129038	9.63	8.92	8.92	8.80	9.31	9.67	-0.00180671342279843	4.14841990477913	0.981981993786395	1	15:73925988-73952137:+	LOXL1	16;GO:0001669,cellular_component acrosomal vesicle;GO:0005507,molecular_function copper ion binding;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005604,cellular_component basement membrane;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0016491,molecular_function oxidoreductase activity;GO:0016641,molecular_function oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0018277,biological_process protein deamination;GO:0030198,biological_process extracellular matrix organization;GO:0031012,cellular_component extracellular matrix;GO:0032496,biological_process response to lipopolysaccharide;GO:0035904,biological_process aorta development;GO:0046872,molecular_function metal ion binding;GO:0055114,biological_process oxidation-reduction process	NA	lysyl oxidase like 1 [Source:HGNC Symbol%3BAcc:HGNC:6665]
ENSG00000171861	10.51	9.01	10.90	8.64	11.23	11.02	-0.00292270994964204	3.73510609785502	0.982157476812342	1	17:782272-792509:+	MRM3	13;GO:0000451,biological_process rRNA 2'-O-methylation;GO:0001510,biological_process RNA methylation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006364,biological_process rRNA processing;GO:0006396,biological_process RNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0070039,molecular_function rRNA (guanosine-2'-O-)-methyltransferase activity	NA	mitochondrial rRNA methyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:18485]
ENSG00000160584	11.47	11.65	11.13	11.15	11.63	11.68	0.00139265032536346	5.60371843275216	0.982321920509601	1	11:116843401-117098437:-	SIK3	4;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005524,molecular_function ATP binding;GO:0006468,biological_process protein phosphorylation	SIK2; serine/threonine-protein kinase SIK2 [EC:2.7.11.1]; K16311	SIK family kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:29165]
ENSG00000169251	36.24	37.42	38.50	36.78	36.88	39.54	-0.00262975185392305	5.91739179608796	0.982414491825308	1	3:161104695-161253532:+	NMD3	14;GO:0000055,biological_process ribosomal large subunit export from nucleus;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030674,molecular_function protein binding, bridging;GO:0032092,biological_process positive regulation of protein binding;GO:0043023,molecular_function ribosomal large subunit binding;GO:1902680,biological_process positive regulation of RNA biosynthetic process;GO:1904751,biological_process positive regulation of protein localization to nucleolus	NMD3; nonsense-mediated mRNA decay protein 3; K07562	NMD3 ribosome export adaptor [Source:HGNC Symbol%3BAcc:HGNC:24250]
ENSG00000105193	966.58	915.69	924.53	961.23	903.48	962.50	0.00144732137279814	8.98209551914201	0.982524333799629	1	19:39433206-39435948:-	RPS16	23;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0015935,cellular_component small ribosomal subunit;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0042274,biological_process ribosomal small subunit biogenesis;GO:0070062,cellular_component extracellular exosome;GO:0097421,biological_process liver regeneration;GO:1990830,biological_process cellular response to leukemia inhibitory factor	RP-S16e, RPS16; small subunit ribosomal protein S16e; K02960	ribosomal protein S16 [Source:HGNC Symbol%3BAcc:HGNC:10396]
ENSG00000099899	14.15	14.11	14.49	14.16	15.32	13.55	0.00394798675152288	4.81024008835421	0.982705032251205	1	22:20111865-20117392:-	TRMT2A	8;GO:0001510,biological_process RNA methylation;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0006396,biological_process RNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0008173,molecular_function RNA methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation	NA	tRNA methyltransferase 2 homolog A [Source:HGNC Symbol%3BAcc:HGNC:24974]
ENSG00000176208	3.57	3.37	3.26	3.57	3.32	3.37	0.0053246275465084	4.25061129142196	0.98286201415116	1	17:30831969-30895869:+	ATAD5	8;GO:0000166,molecular_function nucleotide binding;GO:0002377,biological_process immunoglobulin production;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0030890,biological_process positive regulation of B cell proliferation;GO:0048304,biological_process positive regulation of isotype switching to IgG isotypes;GO:1901990,biological_process regulation of mitotic cell cycle phase transition	NA	ATPase family%2C AAA domain containing 5 [Source:HGNC Symbol%3BAcc:HGNC:25752]
ENSG00000112033	42.34	34.35	42.26	40.65	37.84	41.84	2.98043004240006e-05	5.74894684116588	0.98320928967421	1	6:35342557-35428191:+	PPARD	83;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001890,biological_process placenta development;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003707,molecular_function steroid hormone receptor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004879,molecular_function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005504,molecular_function fatty acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006006,biological_process glucose metabolic process;GO:0006029,biological_process proteoglycan metabolic process;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006629,biological_process lipid metabolic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0006776,biological_process vitamin A metabolic process;GO:0006915,biological_process apoptotic process;GO:0007507,biological_process heart development;GO:0007566,biological_process embryo implantation;GO:0008134,molecular_function transcription factor binding;GO:0008144,molecular_function drug binding;GO:0008203,biological_process cholesterol metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008289,molecular_function lipid binding;GO:0008366,biological_process axon ensheathment;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009062,biological_process fatty acid catabolic process;GO:0009299,biological_process mRNA transcription;GO:0009749,biological_process response to glucose;GO:0010033,biological_process response to organic substance;GO:0010628,biological_process positive regulation of gene expression;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823,biological_process response to activity;GO:0014842,biological_process regulation of skeletal muscle satellite cell proliferation;GO:0014912,biological_process negative regulation of smooth muscle cell migration;GO:0015758,biological_process glucose transport;GO:0015908,biological_process fatty acid transport;GO:0019395,biological_process fatty acid oxidation;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0030522,biological_process intracellular receptor signaling pathway;GO:0031589,biological_process cell-substrate adhesion;GO:0032024,biological_process positive regulation of insulin secretion;GO:0032966,biological_process negative regulation of collagen biosynthetic process;GO:0033189,biological_process response to vitamin A;GO:0042060,biological_process wound healing;GO:0042127,biological_process regulation of cell proliferation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043401,biological_process steroid hormone mediated signaling pathway;GO:0043415,biological_process positive regulation of skeletal muscle tissue regeneration;GO:0043565,molecular_function sequence-specific DNA binding;GO:0043616,biological_process keratinocyte proliferation;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045662,biological_process negative regulation of myoblast differentiation;GO:0045684,biological_process positive regulation of epidermis development;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0046697,biological_process decidualization;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048662,biological_process negative regulation of smooth muscle cell proliferation;GO:0050680,biological_process negative regulation of epithelial cell proliferation;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051059,molecular_function NF-kappaB binding;GO:0051546,biological_process keratinocyte migration;GO:0060612,biological_process adipose tissue development;GO:0070539,molecular_function linoleic acid binding;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071456,biological_process cellular response to hypoxia;GO:0097190,biological_process apoptotic signaling pathway;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1902894,biological_process negative regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:2000288,biological_process positive regulation of myoblast proliferation	NR1C2, PPARD; peroxisome proliferator-activated receptor delta; K04504	peroxisome proliferator activated receptor delta [Source:HGNC Symbol%3BAcc:HGNC:9235]
ENSG00000182400	35.54	34.20	40.91	37.36	35.13	39.53	-0.00226172917556445	4.15587093979604	0.983491991664494	1	14:39147810-39170532:-	TRAPPC6B	15;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0016192,biological_process vesicle-mediated transport;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0030008,cellular_component TRAPP complex;GO:0043547,biological_process positive regulation of GTPase activity;GO:0048208,biological_process COPII vesicle coating;GO:0061024,biological_process membrane organization	NA	trafficking protein particle complex 6B [Source:HGNC Symbol%3BAcc:HGNC:23066]
ENSG00000165156	11.87	12.22	11.33	10.78	11.93	12.89	0.00106064986120857	4.96138823639066	0.983548031024277	1	8:123248450-123275541:-	ZHX1	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030154,biological_process cell differentiation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity	NA	zinc fingers and homeoboxes 1 [Source:HGNC Symbol%3BAcc:HGNC:12871]
ENSG00000136240	327.22	379.05	342.32	348.24	364.75	342.82	0.00109650440464012	8.19365133464835	0.983576693206615	1	7:6445952-6484242:-	KDELR2	17;GO:0000139,cellular_component Golgi membrane;GO:0005046,molecular_function KDEL sequence binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005801,cellular_component cis-Golgi network;GO:0006621,biological_process protein retention in ER lumen;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0046923,molecular_function ER retention sequence binding;GO:0070062,cellular_component extracellular exosome	KDELR; ER lumen protein retaining receptor; K10949	KDEL endoplasmic reticulum protein retention receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:6305]
ENSG00000155115	101.68	99.30	98.37	101.12	98.75	102.34	-0.00184091573674883	6.0059973262858	0.983622435299714	1	6:110958559-110967890:+	GTF3C6	10;GO:0000127,cellular_component transcription factor TFIIIC complex;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0016604,cellular_component nuclear body;GO:0042791,biological_process 5S class rRNA transcription from RNA polymerase III type 1 promoter;GO:0042797,biological_process tRNA transcription from RNA polymerase III promoter	NA	general transcription factor IIIC subunit 6 [Source:HGNC Symbol%3BAcc:HGNC:20872]
ENSG00000105355	106.79	110.48	103.90	110.25	107.74	106.07	-0.00190353509644562	7.19973636673523	0.983678354072721	1	19:4838340-4867768:-	PLIN3	12;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005811,cellular_component lipid particle;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0030133,cellular_component transport vesicle;GO:0045296,molecular_function cadherin binding	NA	perilipin 3 [Source:HGNC Symbol%3BAcc:HGNC:16893]
ENSG00000198380	49.78	46.99	48.89	49.34	47.02	50.37	0.00208156587527541	6.67863325172992	0.98375945605993	1	2:69319768-69387254:-	GFPT1	17;GO:0004360,molecular_function glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0005829,cellular_component cytosol;GO:0006002,biological_process fructose 6-phosphate metabolic process;GO:0006047,biological_process UDP-N-acetylglucosamine metabolic process;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0006112,biological_process energy reserve metabolic process;GO:0006487,biological_process protein N-linked glycosylation;GO:0006541,biological_process glutamine metabolic process;GO:0008483,molecular_function transaminase activity;GO:0016740,molecular_function transferase activity;GO:0032922,biological_process circadian regulation of gene expression;GO:0036498,biological_process IRE1-mediated unfolded protein response;GO:0048511,biological_process rhythmic process;GO:0070062,cellular_component extracellular exosome;GO:0097367,molecular_function carbohydrate derivative binding;GO:1901135,biological_process carbohydrate derivative metabolic process;GO:1901137,biological_process carbohydrate derivative biosynthetic process	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]; K00820	glutamine--fructose-6-phosphate transaminase 1 [Source:HGNC Symbol%3BAcc:HGNC:4241]
ENSG00000224470	9.19	9.94	9.04	8.73	9.94	9.73	-0.00506211046104651	4.29479081644746	0.983814958557415	1	16:71845990-71885268:+	ATXN1L	14;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003677,molecular_function DNA binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030198,biological_process extracellular matrix organization;GO:0030425,cellular_component dendrite;GO:0042995,cellular_component cell projection;GO:0048286,biological_process lung alveolus development;GO:1902035,biological_process positive regulation of hematopoietic stem cell proliferation	NA	ataxin 1 like [Source:HGNC Symbol%3BAcc:HGNC:33279]
ENSG00000143479	9.56	10.79	10.58	11.01	9.07	10.94	0.00181065576919901	4.21188247483908	0.984542433032927	1	1:206635535-206684419:+	DYRK3	25;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004712,molecular_function protein serine/threonine/tyrosine kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030218,biological_process erythrocyte differentiation;GO:0035617,biological_process stress granule disassembly;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043518,biological_process negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0046872,molecular_function metal ion binding;GO:0080135,biological_process regulation of cellular response to stress;GO:1903432,biological_process regulation of TORC1 signaling	NA	dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol%3BAcc:HGNC:3094]
ENSG00000106477	13.61	13.27	12.84	15.45	12.72	12.00	-0.00326528700939143	4.14608516818159	0.984656018955927	1	7:130393770-130442433:-	CEP41	19;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0018095,biological_process protein polyglutamylation;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0060271,biological_process cilium morphogenesis;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	centrosomal protein 41 [Source:HGNC Symbol%3BAcc:HGNC:12370]
ENSG00000110721	11.33	10.47	13.44	11.58	12.52	11.42	0.00830459062017851	4.19239097700898	0.984762202966545	1	11:68052858-68121444:-	CHKA	25;GO:0000166,molecular_function nucleotide binding;GO:0004103,molecular_function choline kinase activity;GO:0004104,molecular_function cholinesterase activity;GO:0004305,molecular_function ethanolamine kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006580,biological_process ethanolamine metabolic process;GO:0006629,biological_process lipid metabolic process;GO:0006646,biological_process phosphatidylethanolamine biosynthetic process;GO:0006656,biological_process phosphatidylcholine biosynthetic process;GO:0006657,biological_process CDP-choline pathway;GO:0006869,biological_process lipid transport;GO:0007165,biological_process signal transduction;GO:0008144,molecular_function drug binding;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009636,biological_process response to toxic substance;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0019695,biological_process choline metabolic process;GO:0033265,molecular_function choline binding;GO:0042803,molecular_function protein homodimerization activity;GO:1904681,biological_process response to 3-methylcholanthrene	CHK; choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]; K14156	choline kinase alpha [Source:HGNC Symbol%3BAcc:HGNC:1937]
ENSG00000163659	25.38	26.63	29.00	28.30	26.08	27.42	-0.00211439655913283	5.76362766234767	0.98482091624521	1	3:156673234-156706770:+	TIPARP	24;GO:0001570,biological_process vasculogenesis;GO:0001822,biological_process kidney development;GO:0003950,molecular_function NAD+ ADP-ribosyltransferase activity;GO:0005634,cellular_component nucleus;GO:0006471,biological_process protein ADP-ribosylation;GO:0006807,biological_process nitrogen compound metabolic process;GO:0008209,biological_process androgen metabolic process;GO:0008210,biological_process estrogen metabolic process;GO:0008585,biological_process female gonad development;GO:0009791,biological_process post-embryonic development;GO:0010629,biological_process negative regulation of gene expression;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030097,biological_process hemopoiesis;GO:0035326,molecular_function enhancer binding;GO:0044236,biological_process multicellular organism metabolic process;GO:0045732,biological_process positive regulation of protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0048008,biological_process platelet-derived growth factor receptor signaling pathway;GO:0048705,biological_process skeletal system morphogenesis;GO:0048745,biological_process smooth muscle tissue development;GO:0060021,biological_process palate development;GO:0060325,biological_process face morphogenesis;GO:0071407,biological_process cellular response to organic cyclic compound	NA	TCDD inducible poly(ADP-ribose) polymerase [Source:HGNC Symbol%3BAcc:HGNC:23696]
ENSG00000183808	20.16	20.24	19.19	19.80	20.03	20.30	-0.00244645427849097	5.90912099992181	0.984847248956946	1	8:93729355-93741017:-	RBM12B	3;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding	NA	RNA binding motif protein 12B [Source:HGNC Symbol%3BAcc:HGNC:32310]
ENSG00000197223	41.33	37.87	38.30	41.04	35.81	41.41	0.00420633642407062	4.42024342333219	0.984938033464923	1	2:68041129-68110948:-	C1D	17;GO:0000176,cellular_component nuclear exosome (RNase complex);GO:0000460,biological_process maturation of 5.8S rRNA;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006364,biological_process rRNA processing;GO:0006915,biological_process apoptotic process;GO:0016922,molecular_function ligand-dependent nuclear receptor binding;GO:0017053,cellular_component transcriptional repressor complex;GO:0045892,biological_process negative regulation of transcription, DNA-templated	C1D, LRP1; exosome complex protein LRP1; K12592	C1D nuclear receptor corepressor [Source:HGNC Symbol%3BAcc:HGNC:29911]
ENSG00000182325	11.27	11.88	10.65	9.91	11.07	12.96	0.000419488127094641	4.20218242621061	0.985136782443448	1	8:144355430-144359376:-	FBXL6	3;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0006508,biological_process proteolysis;GO:0016567,biological_process protein ubiquitination	NA	F-box and leucine rich repeat protein 6 [Source:HGNC Symbol%3BAcc:HGNC:13603]
ENSG00000156795	19.30	25.01	25.26	21.92	24.36	23.50	0.00134271544560541	4.17358069520797	0.985556219454712	1	8:123416724-123467230:+	WDYHV1	8;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006464,biological_process cellular protein modification process;GO:0016787,molecular_function hydrolase activity;GO:0016811,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0070773,molecular_function protein-N-terminal glutamine amidohydrolase activity	NA	WDYHV motif containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25490]
ENSG00000184381	7.49	7.91	8.07	7.51	7.34	8.75	0.00106404453725151	4.46334153993413	0.985630256472496	1	22:38111494-38205690:-	PLA2G6	37;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004623,molecular_function phospholipase A2 activity;GO:0005516,molecular_function calmodulin binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006935,biological_process chemotaxis;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007613,biological_process memory;GO:0008152,biological_process metabolic process;GO:0014832,biological_process urinary bladder smooth muscle contraction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019731,biological_process antibacterial humoral response;GO:0019901,molecular_function protein kinase binding;GO:0032049,biological_process cardiolipin biosynthetic process;GO:0034976,biological_process response to endoplasmic reticulum stress;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043008,molecular_function ATP-dependent protein binding;GO:0045921,biological_process positive regulation of exocytosis;GO:0047499,molecular_function calcium-independent phospholipase A2 activity;GO:0051967,biological_process negative regulation of synaptic transmission, glutamatergic;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0090037,biological_process positive regulation of protein kinase C signaling;GO:0090200,biological_process positive regulation of release of cytochrome c from mitochondria;GO:0090238,biological_process positive regulation of arachidonic acid secretion;GO:0097755,biological_process positive regulation of blood vessel diameter;GO:1901339,biological_process regulation of store-operated calcium channel activity;GO:2000304,biological_process positive regulation of ceramide biosynthetic process	PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4]; K16343	phospholipase A2 group VI [Source:HGNC Symbol%3BAcc:HGNC:9039]
ENSG00000188931	39.10	31.14	34.93	33.56	32.85	40.13	-0.00111006480370244	4.24578953111051	0.98581475448986	1	1:161364730-161367874:-	CFAP126	10;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0016020,cellular_component membrane;GO:0016324,cellular_component apical plasma membrane;GO:0030030,biological_process cell projection organization;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0044782,biological_process cilium organization	NA	cilia and flagella associated protein 126 [Source:HGNC Symbol%3BAcc:HGNC:32325]
ENSG00000154309	4.06	3.51	3.96	4.08	4.40	3.23	-0.00207720341582632	4.16122083298762	0.986083763498626	1	1:222872270-223005995:+	DISP1	16;GO:0005515,molecular_function protein binding;GO:0007224,biological_process smoothened signaling pathway;GO:0007225,biological_process patched ligand maturation;GO:0007275,biological_process multicellular organism development;GO:0007368,biological_process determination of left/right symmetry;GO:0007389,biological_process pattern specification process;GO:0009880,biological_process embryonic pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0015197,molecular_function peptide transporter activity;GO:0015833,biological_process peptide transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0050708,biological_process regulation of protein secretion;GO:0060539,biological_process diaphragm development;GO:0070207,biological_process protein homotrimerization	NA	dispatched RND transporter family member 1 [Source:HGNC Symbol%3BAcc:HGNC:19711]
ENSG00000179941	8.47	9.03	8.79	8.22	10.42	7.91	-0.00279741961202258	4.2653268233402	0.986238238414019	1	12:76344473-76348442:-	BBS10	13;GO:0000166,molecular_function nucleotide binding;GO:0001103,molecular_function RNA polymerase II repressing transcription factor binding;GO:0001895,biological_process retina homeostasis;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005929,cellular_component cilium;GO:0007601,biological_process visual perception;GO:0042995,cellular_component cell projection;GO:0043254,biological_process regulation of protein complex assembly;GO:0045494,biological_process photoreceptor cell maintenance;GO:0050896,biological_process response to stimulus;GO:0051131,biological_process chaperone-mediated protein complex assembly;GO:1905515,biological_process non-motile cilium assembly	NA	Bardet-Biedl syndrome 10 [Source:HGNC Symbol%3BAcc:HGNC:26291]
ENSG00000176853	25.03	26.60	28.14	25.87	27.76	26.70	0.00149012226408918	6.10693323163087	0.986329452514736	1	8:123768455-123815452:+	FAM91A1	NA	NA	family with sequence similarity 91 member A1 [Source:HGNC Symbol%3BAcc:HGNC:26306]
ENSG00000138663	38.60	41.15	38.31	39.52	36.73	42.82	-0.00348512685260397	5.88486483953098	0.986712033053851	1	4:83034446-83075818:+	COPS4	17;GO:0000338,biological_process protein deneddylation;GO:0000715,biological_process nucleotide-excision repair, DNA damage recognition;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0008021,cellular_component synaptic vesicle;GO:0008180,cellular_component COP9 signalosome;GO:0016607,cellular_component nuclear speck;GO:0019784,molecular_function NEDD8-specific protease activity;GO:0030054,cellular_component cell junction;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043687,biological_process post-translational protein modification;GO:0045202,cellular_component synapse;GO:0070062,cellular_component extracellular exosome	NA	COP9 signalosome subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:16702]
ENSG00000108591	25.38	27.12	24.74	25.43	25.95	26.24	0.000178121470153392	4.91442346571456	0.987096082936222	1	17:18087885-18107971:+	DRG2	10;GO:0000166,molecular_function nucleotide binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	developmentally regulated GTP binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:3030]
ENSG00000124596	46.48	42.54	42.02	45.04	41.35	46.05	-0.00197425716922071	4.77720634208119	0.987140565026967	1	6:41033626-41097787:-	OARD1	5;GO:0001883,molecular_function purine nucleoside binding;GO:0005515,molecular_function protein binding;GO:0016787,molecular_function hydrolase activity;GO:0019213,molecular_function deacetylase activity;GO:0042278,biological_process purine nucleoside metabolic process	NA	O-acyl-ADP-ribose deacylase 1 [Source:HGNC Symbol%3BAcc:HGNC:21257]
ENSG00000013583	135.05	127.64	138.41	137.11	130.76	137.18	-0.000617878891787092	6.26098556958051	0.987565817996935	1	12:12974863-13000273:-	HEBP1	5;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0007623,biological_process circadian rhythm;GO:0020037,molecular_function heme binding;GO:0070062,cellular_component extracellular exosome	NA	heme binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17176]
ENSG00000100522	45.68	44.15	46.27	49.78	41.91	45.86	-0.00206847736131089	4.6644162568076	0.987632428358106	1	14:52775193-52791668:-	GNPNAT1	19;GO:0000139,cellular_component Golgi membrane;GO:0001889,biological_process liver development;GO:0004343,molecular_function glucosamine 6-phosphate N-acetyltransferase activity;GO:0005768,cellular_component endosome;GO:0005770,cellular_component late endosome;GO:0005793,cellular_component endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006041,biological_process glucosamine metabolic process;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006048,biological_process UDP-N-acetylglucosamine biosynthetic process;GO:0008080,molecular_function N-acetyltransferase activity;GO:0010008,cellular_component endosome membrane;GO:0016020,cellular_component membrane;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0042802,molecular_function identical protein binding;GO:0048029,molecular_function monosaccharide binding;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	glucosamine-phosphate N-acetyltransferase 1 [Source:HGNC Symbol%3BAcc:HGNC:19980]
ENSG00000136381	18.97	17.55	17.73	17.21	18.21	19.22	0.002309560430759	5.73315869825533	0.987790422588649	1	15:78437430-78501456:+	IREB2	22;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0006782,biological_process protoporphyrinogen IX biosynthetic process;GO:0006826,biological_process iron ion transport;GO:0006879,biological_process cellular iron ion homeostasis;GO:0008152,biological_process metabolic process;GO:0009791,biological_process post-embryonic development;GO:0010468,biological_process regulation of gene expression;GO:0017148,biological_process negative regulation of translation;GO:0030316,biological_process osteoclast differentiation;GO:0030350,molecular_function iron-responsive element binding;GO:0030371,molecular_function translation repressor activity;GO:0034101,biological_process erythrocyte homeostasis;GO:0046872,molecular_function metal ion binding;GO:0050892,biological_process intestinal absorption;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0055072,biological_process iron ion homeostasis	NA	iron responsive element binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:6115]
ENSG00000134686	38.78	32.52	38.76	40.38	31.23	39.27	0.00265397646621061	6.57322990822689	0.988046678936475	1	1:33323622-33431052:-	PHC2	12;GO:0000792,cellular_component heterochromatin;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0031519,cellular_component PcG protein complex;GO:0035102,cellular_component PRC1 complex;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding	NA	polyhomeotic homolog 2 [Source:HGNC Symbol%3BAcc:HGNC:3183]
ENSG00000163867	5.34	5.54	6.17	5.28	6.09	5.86	-0.00264769705715952	4.54554388155929	0.988142547308674	1	1:34986164-35031968:-	ZMYM6	12;GO:0000981,molecular_function RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0007010,biological_process cytoskeleton organization;GO:0007275,biological_process multicellular organism development;GO:0008270,molecular_function zinc ion binding;GO:0022604,biological_process regulation of cell morphogenesis;GO:0046872,molecular_function metal ion binding	NA	zinc finger MYM-type containing 6 [Source:HGNC Symbol%3BAcc:HGNC:13050]
ENSG00000051382	22.18	25.13	20.86	22.26	24.27	22.04	8.38687982143609e-05	6.20171707113206	0.988178154189803	1	3:138652698-138834938:-	PIK3CB	58;GO:0000166,molecular_function nucleotide binding;GO:0000187,biological_process activation of MAPK activity;GO:0001935,biological_process endothelial cell proliferation;GO:0001952,biological_process regulation of cell-matrix adhesion;GO:0002250,biological_process adaptive immune response;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005942,cellular_component phosphatidylinositol 3-kinase complex;GO:0006661,biological_process phosphatidylinositol biosynthetic process;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0006897,biological_process endocytosis;GO:0006914,biological_process autophagy;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0007155,biological_process cell adhesion;GO:0007156,biological_process homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007411,biological_process axon guidance;GO:0009611,biological_process response to wounding;GO:0010508,biological_process positive regulation of autophagy;GO:0010628,biological_process positive regulation of gene expression;GO:0014065,biological_process phosphatidylinositol 3-kinase signaling;GO:0014066,biological_process regulation of phosphatidylinositol 3-kinase signaling;GO:0016301,molecular_function kinase activity;GO:0016303,molecular_function 1-phosphatidylinositol-3-kinase activity;GO:0016310,biological_process phosphorylation;GO:0016477,biological_process cell migration;GO:0016740,molecular_function transferase activity;GO:0030168,biological_process platelet activation;GO:0030496,cellular_component midbody;GO:0033031,biological_process positive regulation of neutrophil apoptotic process;GO:0035004,molecular_function phosphatidylinositol 3-kinase activity;GO:0035005,molecular_function 1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0036092,biological_process phosphatidylinositol-3-phosphate biosynthetic process;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0038111,biological_process interleukin-7-mediated signaling pathway;GO:0040016,biological_process embryonic cleavage;GO:0043560,molecular_function insulin receptor substrate binding;GO:0045087,biological_process innate immune response;GO:0046854,biological_process phosphatidylinositol phosphorylation;GO:0046934,molecular_function phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048015,biological_process phosphatidylinositol-mediated signaling;GO:0050852,biological_process T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0060055,biological_process angiogenesis involved in wound healing;GO:0060326,biological_process cell chemotaxis;GO:0070527,biological_process platelet aggregation;GO:2000369,biological_process regulation of clathrin-mediated endocytosis	PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]; K00922	phosphatidylinositol-4%2C5-bisphosphate 3-kinase catalytic subunit beta [Source:HGNC Symbol%3BAcc:HGNC:8976]
ENSG00000136527	109.91	122.55	109.46	116.60	116.98	111.23	-0.00238703935650442	6.75441609427819	0.988275177720353	1	3:185915905-185938136:-	TRA2B	24;GO:0000375,biological_process RNA splicing, via transesterification reactions;GO:0000381,biological_process regulation of alternative mRNA splicing, via spliceosome;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0019904,molecular_function protein domain specific binding;GO:0021796,biological_process cerebral cortex regionalization;GO:0036002,molecular_function pre-mRNA binding;GO:0042802,molecular_function identical protein binding;GO:0043484,biological_process regulation of RNA splicing;GO:0048025,biological_process negative regulation of mRNA splicing, via spliceosome;GO:0048026,biological_process positive regulation of mRNA splicing, via spliceosome;GO:0051259,biological_process protein oligomerization;GO:0070717,molecular_function poly-purine tract binding;GO:0071333,biological_process cellular response to glucose stimulus;GO:1990403,biological_process embryonic brain development	TRA2; transformer-2 protein; K12897	transformer 2 beta homolog [Source:HGNC Symbol%3BAcc:HGNC:10781]
ENSG00000079308	9.84	11.06	10.60	9.62	12.20	9.96	-0.00249655064932443	5.97982728167247	0.988572157387398	1	2:217799788-218002995:-	TNS1	13;GO:0003723,molecular_function RNA binding;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005925,cellular_component focal adhesion;GO:0007044,biological_process cell-substrate junction assembly;GO:0009986,cellular_component cell surface;GO:0010761,biological_process fibroblast migration;GO:0030054,cellular_component cell junction;GO:0030055,cellular_component cell-substrate junction;GO:0035556,biological_process intracellular signal transduction	NA	tensin 1 [Source:HGNC Symbol%3BAcc:HGNC:11973]
ENSG00000174444	1071.71	1031.80	1024.97	1082.20	1003.85	1069.94	-0.000853678903801641	10.3943701333597	0.988698817809148	1	15:66498014-66524532:-	RPL4	21;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005791,cellular_component rough endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0016020,cellular_component membrane;GO:0019083,biological_process viral transcription;GO:0022625,cellular_component cytosolic large ribosomal subunit;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070062,cellular_component extracellular exosome	RP-L4e, RPL4; large subunit ribosomal protein L4e; K02930	ribosomal protein L4 [Source:HGNC Symbol%3BAcc:HGNC:10353]
ENSG00000136824	18.07	20.78	16.78	17.52	20.27	18.30	-0.00344022774769044	6.07630320734761	0.988971214853117	1	9:104094259-104141417:+	SMC2	22;GO:0000166,molecular_function nucleotide binding;GO:0000228,cellular_component nuclear chromosome;GO:0000793,cellular_component condensed chromosome;GO:0000796,cellular_component condensin complex;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007076,biological_process mitotic chromosome condensation;GO:0010032,biological_process meiotic chromosome condensation;GO:0030261,biological_process chromosome condensation;GO:0045132,biological_process meiotic chromosome segregation;GO:0046982,molecular_function protein heterodimerization activity;GO:0051276,biological_process chromosome organization;GO:0051301,biological_process cell division;GO:0051383,biological_process kinetochore organization;GO:0070062,cellular_component extracellular exosome	NA	structural maintenance of chromosomes 2 [Source:HGNC Symbol%3BAcc:HGNC:14011]
ENSG00000198860	40.39	34.12	41.10	38.77	40.30	38.07	0.00157647195845041	4.53288738094771	0.989058936543288	1	1:184051676-184074212:+	TSEN15	11;GO:0000213,molecular_function tRNA-intron endonuclease activity;GO:0004519,molecular_function endonuclease activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0006397,biological_process mRNA processing;GO:0008033,biological_process tRNA processing;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:0090501,biological_process RNA phosphodiester bond hydrolysis;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic	NA	tRNA splicing endonuclease subunit 15 [Source:HGNC Symbol%3BAcc:HGNC:16791]
ENSG00000136243	26.18	24.17	25.78	26.37	26.05	24.54	0.000153153369293437	5.37027724111578	0.989162916497839	1	7:23181826-23201011:+	NUPL2	26;GO:0003723,molecular_function RNA binding;GO:0005049,molecular_function nuclear export signal receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006611,biological_process protein export from nucleus;GO:0006810,biological_process transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0043657,cellular_component host cell;GO:0046872,molecular_function metal ion binding;GO:0051028,biological_process mRNA transport;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUPL2, NUP42, CG1; nucleoporin-like protein 2; K14321	nucleoporin like 2 [Source:HGNC Symbol%3BAcc:HGNC:17010]
ENSG00000100281	12.69	14.12	12.82	13.00	13.71	13.10	-0.000144145964304224	4.59816372274973	0.989443599900161	1	22:35257451-35295807:+	HMGXB4	6;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0008333,biological_process endosome to lysosome transport;GO:0016055,biological_process Wnt signaling pathway;GO:0016589,cellular_component NURF complex;GO:0030178,biological_process negative regulation of Wnt signaling pathway	NA	HMG-box containing 4 [Source:HGNC Symbol%3BAcc:HGNC:5003]
ENSG00000113456	35.00	37.70	35.82	39.93	33.03	36.49	-0.00375700652456528	5.03743146425925	0.989872348501294	1	5:34905263-34918989:-	RAD1	21;GO:0000077,biological_process DNA damage checkpoint;GO:0003684,molecular_function damaged DNA binding;GO:0004518,molecular_function nuclease activity;GO:0004527,molecular_function exonuclease activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0008853,molecular_function exodeoxyribonuclease III activity;GO:0016787,molecular_function hydrolase activity;GO:0021762,biological_process substantia nigra development;GO:0030896,cellular_component checkpoint clamp complex;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051598,biological_process meiotic recombination checkpoint;GO:0071479,biological_process cellular response to ionizing radiation;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	HRAD1, RAD17; cell cycle checkpoint protein [EC:3.1.11.2]; K02830	RAD1 checkpoint DNA exonuclease [Source:HGNC Symbol%3BAcc:HGNC:9806]
ENSG00000147669	213.48	231.78	217.47	227.66	216.89	222.09	-0.000115109445324857	5.61790695344685	0.99007822200384	1	8:100150583-100154002:+	POLR2K	33;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0001054,molecular_function RNA polymerase I activity;GO:0001055,molecular_function RNA polymerase II activity;GO:0001056,molecular_function RNA polymerase III activity;GO:0003677,molecular_function DNA binding;GO:0003899,molecular_function DNA-directed RNA polymerase activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005665,cellular_component DNA-directed RNA polymerase II, core complex;GO:0005666,cellular_component DNA-directed RNA polymerase III complex;GO:0005736,cellular_component DNA-directed RNA polymerase I complex;GO:0005829,cellular_component cytosol;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006351,biological_process transcription, DNA-templated;GO:0006356,biological_process regulation of transcription from RNA polymerase I promoter;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006383,biological_process transcription from RNA polymerase III promoter;GO:0008270,molecular_function zinc ion binding;GO:0008543,biological_process fibroblast growth factor receptor signaling pathway;GO:0016070,biological_process RNA metabolic process;GO:0032481,biological_process positive regulation of type I interferon production;GO:0035019,biological_process somatic stem cell population maintenance;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0046872,molecular_function metal ion binding;GO:0050434,biological_process positive regulation of viral transcription;GO:0060964,biological_process regulation of gene silencing by miRNA	NA	RNA polymerase II subunit K [Source:HGNC Symbol%3BAcc:HGNC:9198]
ENSG00000063854	33.10	30.66	29.95	32.13	33.32	29.25	-0.000648732788052298	4.96347356617763	0.990178581204345	1	16:1795619-1827194:-	HAGH	12;GO:0004416,molecular_function hydroxyacylglutathione hydrolase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006090,biological_process pyruvate metabolic process;GO:0006750,biological_process glutathione biosynthetic process;GO:0016787,molecular_function hydrolase activity;GO:0019243,biological_process methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	gloB, gloC, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]; K01069	hydroxyacylglutathione hydrolase [Source:HGNC Symbol%3BAcc:HGNC:4805]
ENSG00000197345	31.72	28.33	30.69	29.90	29.11	32.75	-0.000659280251891183	4.79257128620797	0.99036088444001	1	11:68891275-68903835:-	MRPL21	11;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005622,cellular_component intracellular;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	RP-L21, MRPL21, rplU; large subunit ribosomal protein L21; K02888	mitochondrial ribosomal protein L21 [Source:HGNC Symbol%3BAcc:HGNC:14479]
ENSG00000004059	214.49	225.29	201.86	224.75	210.39	210.95	0.000361177018120237	6.85890999800876	0.991377893195352	1	7:127588344-127591705:+	ARF5	16;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006890,biological_process retrograde vesicle-mediated transport, Golgi to ER;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0070062,cellular_component extracellular exosome	NA	ADP ribosylation factor 5 [Source:HGNC Symbol%3BAcc:HGNC:658]
ENSG00000169764	83.78	89.17	83.45	86.06	85.29	87.23	-0.00156704050763004	7.21951574885444	0.991396042079543	1	2:63840939-63891562:+	UGP2	19;GO:0003983,molecular_function UTP:glucose-1-phosphate uridylyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005536,molecular_function glucose binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0006011,biological_process UDP-glucose metabolic process;GO:0006065,biological_process UDP-glucuronate biosynthetic process;GO:0008152,biological_process metabolic process;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019255,biological_process glucose 1-phosphate metabolic process;GO:0032557,molecular_function pyrimidine ribonucleotide binding;GO:0042802,molecular_function identical protein binding;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0070569,molecular_function uridylyltransferase activity	UGP2, galU, galF; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]; K00963	UDP-glucose pyrophosphorylase 2 [Source:HGNC Symbol%3BAcc:HGNC:12527]
ENSG00000204842	11.21	10.78	12.57	12.18	11.23	11.42	0.00296604202926158	5.65182702920037	0.991686704607633	1	12:111452213-111599676:-	ATXN2	19;GO:0002091,biological_process negative regulation of receptor internalization;GO:0003723,molecular_function RNA binding;GO:0005154,molecular_function epidermal growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005844,cellular_component polysome;GO:0006417,biological_process regulation of translation;GO:0008022,molecular_function protein C-terminus binding;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010603,biological_process regulation of cytoplasmic mRNA processing body assembly;GO:0016020,cellular_component membrane;GO:0016070,biological_process RNA metabolic process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0034063,biological_process stress granule assembly;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0050658,biological_process RNA transport	NA	ataxin 2 [Source:HGNC Symbol%3BAcc:HGNC:10555]
ENSG00000166250	75.23	68.41	71.30	77.68	65.13	74.15	-0.000587735310516513	6.33635509267448	0.99193309289273	1	11:123069864-123195281:-	CLMP	9;GO:0005881,cellular_component cytoplasmic microtubule;GO:0005886,cellular_component plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0048565,biological_process digestive tract development;GO:0070062,cellular_component extracellular exosome	NA	CXADR like membrane protein [Source:HGNC Symbol%3BAcc:HGNC:24039]
ENSG00000120063	24.10	20.28	24.27	22.31	23.13	24.06	0.00134280389262122	4.71598001552244	0.992292452945752	1	17:65010714-65056839:-	GNA13	42;GO:0000166,molecular_function nucleotide binding;GO:0001525,biological_process angiogenesis;GO:0001569,biological_process patterning of blood vessels;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0001701,biological_process in utero embryonic development;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006928,biological_process movement of cell or subcellular component;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007189,biological_process adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007266,biological_process Rho protein signal transduction;GO:0008360,biological_process regulation of cell shape;GO:0016020,cellular_component membrane;GO:0019001,molecular_function guanyl nucleotide binding;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0030334,biological_process regulation of cell migration;GO:0031526,cellular_component brush border membrane;GO:0031584,biological_process activation of phospholipase D activity;GO:0031683,molecular_function G-protein beta/gamma-subunit complex binding;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0031752,molecular_function D5 dopamine receptor binding;GO:0035556,biological_process intracellular signal transduction;GO:0042470,cellular_component melanosome;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0070062,cellular_component extracellular exosome	NA	G protein subunit alpha 13 [Source:HGNC Symbol%3BAcc:HGNC:4381]
ENSG00000166004	6.19	5.92	5.89	5.96	6.51	5.68	0.002414953614861	5.56831357499119	0.992579964237366	1	11:93661638-93730358:+	CEP295	6;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005814,cellular_component centriole;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:1902117,biological_process positive regulation of organelle assembly	NA	centrosomal protein 295 [Source:HGNC Symbol%3BAcc:HGNC:29366]
ENSG00000101079	18.55	21.68	18.91	19.72	23.00	16.92	-0.0039936790098749	4.61100906573534	0.992898113543436	1	20:36651765-36746078:-	NDRG3	7;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0030154,biological_process cell differentiation;GO:0030308,biological_process negative regulation of cell growth;GO:0070062,cellular_component extracellular exosome	NA	NDRG family member 3 [Source:HGNC Symbol%3BAcc:HGNC:14462]
ENSG00000138448	73.87	64.00	69.19	68.15	68.94	71.63	0.00129113379061245	7.80324076075639	0.993011525581194	1	2:186590064-186680901:+	ITGAV	84;GO:0001525,biological_process angiogenesis;GO:0001568,biological_process blood vessel development;GO:0001570,biological_process vasculogenesis;GO:0001618,molecular_function virus receptor activity;GO:0001846,molecular_function opsonin binding;GO:0001968,molecular_function fibronectin binding;GO:0002020,molecular_function protease binding;GO:0002479,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0005080,molecular_function protein kinase C binding;GO:0005102,molecular_function receptor binding;GO:0005245,molecular_function voltage-gated calcium channel activity;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006874,biological_process cellular calcium ion homeostasis;GO:0007155,biological_process cell adhesion;GO:0007160,biological_process cell-matrix adhesion;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008305,cellular_component integrin complex;GO:0009897,cellular_component external side of plasma membrane;GO:0009986,cellular_component cell surface;GO:0010745,biological_process negative regulation of macrophage derived foam cell differentiation;GO:0010888,biological_process negative regulation of lipid storage;GO:0015026,molecular_function coreceptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0016049,biological_process cell growth;GO:0016477,biological_process cell migration;GO:0017134,molecular_function fibroblast growth factor binding;GO:0019960,molecular_function C-X3-C chemokine binding;GO:0030054,cellular_component cell junction;GO:0030198,biological_process extracellular matrix organization;GO:0030335,biological_process positive regulation of cell migration;GO:0031258,cellular_component lamellipodium membrane;GO:0031527,cellular_component filopodium membrane;GO:0031528,cellular_component microvillus membrane;GO:0031589,biological_process cell-substrate adhesion;GO:0031994,molecular_function insulin-like growth factor I binding;GO:0032369,biological_process negative regulation of lipid transport;GO:0032587,cellular_component ruffle membrane;GO:0033627,biological_process cell adhesion mediated by integrin;GO:0033690,biological_process positive regulation of osteoblast proliferation;GO:0034113,biological_process heterotypic cell-cell adhesion;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0034683,cellular_component integrin alphav-beta3 complex;GO:0034684,cellular_component integrin alphav-beta5 complex;GO:0034685,cellular_component integrin alphav-beta6 complex;GO:0034686,cellular_component integrin alphav-beta8 complex;GO:0035579,cellular_component specific granule membrane;GO:0035867,cellular_component alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0035987,biological_process endodermal cell differentiation;GO:0038027,biological_process apolipoprotein A-I-mediated signaling pathway;GO:0038044,biological_process transforming growth factor-beta secretion;GO:0038132,molecular_function neuregulin binding;GO:0042277,molecular_function peptide binding;GO:0043277,biological_process apoptotic cell clearance;GO:0043312,biological_process neutrophil degranulation;GO:0043410,biological_process positive regulation of MAPK cascade;GO:0045335,cellular_component phagocytic vesicle;GO:0045715,biological_process negative regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0045785,biological_process positive regulation of cell adhesion;GO:0046718,biological_process viral entry into host cell;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0050431,molecular_function transforming growth factor beta binding;GO:0050748,biological_process negative regulation of lipoprotein metabolic process;GO:0050764,biological_process regulation of phagocytosis;GO:0050840,molecular_function extracellular matrix binding;GO:0050900,biological_process leukocyte migration;GO:0050919,biological_process negative chemotaxis;GO:0052066,biological_process entry of symbiont into host cell by promotion of host phagocytosis;GO:0070062,cellular_component extracellular exosome;GO:0070371,biological_process ERK1 and ERK2 cascade;GO:0070588,biological_process calcium ion transmembrane transport;GO:0097192,biological_process extrinsic apoptotic signaling pathway in absence of ligand;GO:1990430,molecular_function extracellular matrix protein binding;GO:2000425,biological_process regulation of apoptotic cell clearance;GO:2000536,biological_process negative regulation of entry of bacterium into host cell;GO:2001237,biological_process negative regulation of extrinsic apoptotic signaling pathway	ITGAV, CD51; integrin alpha V; K06487	integrin subunit alpha V [Source:HGNC Symbol%3BAcc:HGNC:6150]
ENSG00000116489	145.70	134.44	144.29	141.37	139.04	147.93	-0.000252142635654199	6.93341665776337	0.993129929669439	1	1:112619172-112671619:+	CAPZA1	20;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006461,biological_process protein complex assembly;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006928,biological_process movement of cell or subcellular component;GO:0007596,biological_process blood coagulation;GO:0008290,cellular_component F-actin capping protein complex;GO:0015629,cellular_component actin cytoskeleton;GO:0019886,biological_process antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0035722,biological_process interleukin-12-mediated signaling pathway;GO:0045087,biological_process innate immune response;GO:0045296,molecular_function cadherin binding;GO:0051016,biological_process barbed-end actin filament capping;GO:0051693,biological_process actin filament capping;GO:0070062,cellular_component extracellular exosome;GO:0071203,cellular_component WASH complex	CAPZA; capping protein (actin filament) muscle Z-line, alpha; K10364	capping actin protein of muscle Z-line alpha subunit 1 [Source:HGNC Symbol%3BAcc:HGNC:1488]
ENSG00000149292	10.41	7.96	10.61	10.16	8.82	10.36	0.00158797691691995	4.60985150535199	0.993388680120568	1	11:113314528-113383544:+	TTC12	1;GO:0005813,cellular_component centrosome	NA	tetratricopeptide repeat domain 12 [Source:HGNC Symbol%3BAcc:HGNC:23700]
ENSG00000197879	84.72	85.40	85.03	86.11	82.95	88.06	0.000487069341575036	8.14739076032434	0.993565506344589	1	17:1464097-1492812:-	MYO1C	52;GO:0000146,molecular_function microfilament motor activity;GO:0000166,molecular_function nucleotide binding;GO:0001726,cellular_component ruffle;GO:0003774,molecular_function motor activity;GO:0003779,molecular_function actin binding;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005516,molecular_function calmodulin binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005643,cellular_component nuclear pore;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005902,cellular_component microvillus;GO:0005903,cellular_component brush border;GO:0006605,biological_process protein targeting;GO:0006612,biological_process protein targeting to membrane;GO:0006810,biological_process transport;GO:0008022,molecular_function protein C-terminus binding;GO:0009925,cellular_component basal plasma membrane;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016459,cellular_component myosin complex;GO:0016461,cellular_component unconventional myosin complex;GO:0016604,cellular_component nuclear body;GO:0017160,molecular_function Ral GTPase binding;GO:0030335,biological_process positive regulation of cell migration;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0030898,molecular_function actin-dependent ATPase activity;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031941,cellular_component filamentous actin;GO:0032420,cellular_component stereocilium;GO:0032421,cellular_component stereocilium bundle;GO:0032587,cellular_component ruffle membrane;GO:0038089,biological_process positive regulation of cell migration by vascular endothelial growth factor signaling pathway;GO:0038096,biological_process Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042995,cellular_component cell projection;GO:0045121,cellular_component membrane raft;GO:0045160,cellular_component myosin I complex;GO:0045815,biological_process positive regulation of gene expression, epigenetic;GO:0051015,molecular_function actin filament binding;GO:0051028,biological_process mRNA transport;GO:0060171,cellular_component stereocilium membrane;GO:0070062,cellular_component extracellular exosome;GO:0090314,biological_process positive regulation of protein targeting to membrane;GO:1900078,biological_process positive regulation of cellular response to insulin stimulus;GO:1900748,biological_process positive regulation of vascular endothelial growth factor signaling pathway;GO:2000810,biological_process regulation of bicellular tight junction assembly	MYO1; myosin I; K10356	myosin IC [Source:HGNC Symbol%3BAcc:HGNC:7597]
ENSG00000082258	16.90	16.81	17.30	17.14	17.59	16.77	-0.0009337647625441	5.30422218627993	0.993828448979897	1	2:134918234-134959342:+	CCNT2	30;GO:0000079,biological_process regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001223,molecular_function transcription coactivator binding;GO:0003682,molecular_function chromatin binding;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007049,biological_process cell cycle;GO:0007519,biological_process skeletal muscle tissue development;GO:0008024,cellular_component cyclin/CDK positive transcription elongation factor complex;GO:0016032,biological_process viral process;GO:0016538,molecular_function cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019085,biological_process early viral transcription;GO:0019086,biological_process late viral transcription;GO:0042795,biological_process snRNA transcription from RNA polymerase II promoter;GO:0045737,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051301,biological_process cell division;GO:0070063,molecular_function RNA polymerase binding;GO:0097322,molecular_function 7SK snRNA binding;GO:1901409,biological_process positive regulation of phosphorylation of RNA polymerase II C-terminal domain	CCNT; cyclin T; K15188	cyclin T2 [Source:HGNC Symbol%3BAcc:HGNC:1600]
ENSG00000129515	109.45	106.27	106.30	109.32	105.94	109.58	-0.000585455723495758	7.35597971679977	0.994052575372785	1	14:34561093-34630183:-	SNX6	31;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006897,biological_process endocytosis;GO:0007175,biological_process negative regulation of epidermal growth factor-activated receptor activity;GO:0008289,molecular_function lipid binding;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016050,biological_process vesicle organization;GO:0016241,biological_process regulation of macroautophagy;GO:0019898,cellular_component extrinsic component of membrane;GO:0030512,biological_process negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030904,cellular_component retromer complex;GO:0030905,cellular_component retromer, tubulation complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031901,cellular_component early endosome membrane;GO:0034452,molecular_function dynactin binding;GO:0034713,molecular_function type I transforming growth factor beta receptor binding;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0042803,molecular_function protein homodimerization activity;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046982,molecular_function protein heterodimerization activity;GO:0097422,cellular_component tubular endosome	NA	sorting nexin 6 [Source:HGNC Symbol%3BAcc:HGNC:14970]
ENSG00000183291	240.61	242.80	230.53	234.64	233.44	251.95	-0.00115672403829964	7.14197422779383	0.994152582334996	1	1:86862444-86914424:-	SELENOF	NA	NA	selenoprotein F [Source:HGNC Symbol%3BAcc:HGNC:17705]
ENSG00000015676	52.37	57.18	57.36	55.86	54.90	57.27	-0.000108913177431196	5.92175592397003	0.99423393431769	1	7:44379120-44490880:-	NUDCD3	8;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005868,cellular_component cytoplasmic dynein complex;GO:0006457,biological_process protein folding;GO:0032502,biological_process developmental process;GO:0051082,molecular_function unfolded protein binding;GO:0060271,biological_process cilium morphogenesis;GO:1905793,biological_process protein localization to pericentriolar material	NA	NudC domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:22208]
ENSG00000128731	7.87	8.21	7.53	8.29	7.87	7.64	-0.00129028882333146	6.84764046511084	0.994512725355036	1	15:28111039-28322152:-	HERC2	24;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005814,cellular_component centriole;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006886,biological_process intracellular protein transport;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007283,biological_process spermatogenesis;GO:0008270,molecular_function zinc ion binding;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0032183,molecular_function SUMO binding;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]; K10595	HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol%3BAcc:HGNC:4868]
ENSG00000106636	103.54	129.28	108.26	108.07	122.35	112.76	-0.000920272671841655	6.14055181574963	0.994588766630409	1	7:44200967-44214294:+	YKT6	33;GO:0000139,cellular_component Golgi membrane;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0006903,biological_process vesicle targeting;GO:0006904,biological_process vesicle docking involved in exocytosis;GO:0006906,biological_process vesicle fusion;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016740,molecular_function transferase activity;GO:0019706,molecular_function protein-cysteine S-palmitoyltransferase activity;GO:0030133,cellular_component transport vesicle;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031201,cellular_component SNARE complex;GO:0031410,cellular_component cytoplasmic vesicle;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0042147,biological_process retrograde transport, endosome to Golgi;GO:0043025,cellular_component neuronal cell body;GO:0045296,molecular_function cadherin binding;GO:0070062,cellular_component extracellular exosome;GO:0097440,cellular_component apical dendrite;GO:0097441,cellular_component basilar dendrite	YKT6; synaptobrevin homolog YKT6; K08516	YKT6 v-SNARE homolog [Source:HGNC Symbol%3BAcc:HGNC:16959]
ENSG00000145425	1217.45	1173.15	1197.45	1231.43	1165.72	1221.36	-0.000363616933018917	9.89854609187877	0.994955473518773	1	4:151099572-151104652:+	RPS3A	26;GO:0000184,biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0002181,biological_process cytoplasmic translation;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0005840,cellular_component ribosome;GO:0005925,cellular_component focal adhesion;GO:0006364,biological_process rRNA processing;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0006614,biological_process SRP-dependent cotranslational protein targeting to membrane;GO:0019083,biological_process viral transcription;GO:0022627,cellular_component cytosolic small ribosomal subunit;GO:0030154,biological_process cell differentiation;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0031012,cellular_component extracellular matrix;GO:0043066,biological_process negative regulation of apoptotic process;GO:0048027,molecular_function mRNA 5'-UTR binding;GO:0070062,cellular_component extracellular exosome	NA	ribosomal protein S3A [Source:HGNC Symbol%3BAcc:HGNC:10421]
ENSG00000180357	10.28	9.94	10.78	10.78	9.85	10.61	0.0020237006149169	5.54481850514152	0.995047552266911	1	15:64460741-64686068:+	ZNF609	5;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0007517,biological_process muscle organ development;GO:0046872,molecular_function metal ion binding;GO:2000291,biological_process regulation of myoblast proliferation	NA	zinc finger protein 609 [Source:HGNC Symbol%3BAcc:HGNC:29003]
ENSG00000204822	84.50	93.01	86.74	90.92	86.00	89.36	-0.00422228789226118	4.89940025510218	0.995062052686671	1	2:74471957-74473322:-	MRPL53	8;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005762,cellular_component mitochondrial large ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein L53 [Source:HGNC Symbol%3BAcc:HGNC:16684]
ENSG00000180182	15.86	16.25	15.39	15.13	16.39	16.31	0.000139225879462654	6.13260617226443	0.995241012470617	1	X:40648305-40735858:-	MED14	21;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0003712,molecular_function transcription cofactor activity;GO:0003713,molecular_function transcription coactivator activity;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0016020,cellular_component membrane;GO:0016592,cellular_component mediator complex;GO:0019827,biological_process stem cell population maintenance;GO:0030374,molecular_function ligand-dependent nuclear receptor transcription coactivator activity;GO:0030518,biological_process intracellular steroid hormone receptor signaling pathway;GO:0030521,biological_process androgen receptor signaling pathway;GO:0042809,molecular_function vitamin D receptor binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0070847,cellular_component core mediator complex	MED14, RGR1; mediator of RNA polymerase II transcription subunit 14; K15156	mediator complex subunit 14 [Source:HGNC Symbol%3BAcc:HGNC:2370]
ENSG00000107929	23.98	26.51	25.72	25.99	27.05	23.70	0.00025287752786745	5.99589607670238	0.996018900096708	1	10:806913-931705:-	LARP4B	11;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0010494,cellular_component cytoplasmic stress granule;GO:0016020,cellular_component membrane;GO:0042788,cellular_component polysomal ribosome;GO:0045727,biological_process positive regulation of translation	NA	La ribonucleoprotein domain family member 4B [Source:HGNC Symbol%3BAcc:HGNC:28987]
ENSG00000091947	29.92	29.29	35.32	31.54	32.69	31.34	0.00019182339143729	4.70858368332527	0.996259500349558	1	17:44011187-44023946:-	TMEM101	6;GO:0004871,molecular_function signal transducer activity;GO:0005575,cellular_component cellular_component;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling	NA	transmembrane protein 101 [Source:HGNC Symbol%3BAcc:HGNC:28653]
ENSG00000128340	114.34	116.47	114.81	119.26	110.79	118.49	-0.00115422837787523	6.39759006753588	0.996468114815819	1	22:37225260-37244448:-	RAC2	38;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005884,cellular_component actin filament;GO:0005886,cellular_component plasma membrane;GO:0005925,cellular_component focal adhesion;GO:0006935,biological_process chemotaxis;GO:0007015,biological_process actin filament organization;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0008284,biological_process positive regulation of cell proliferation;GO:0010310,biological_process regulation of hydrogen peroxide metabolic process;GO:0010592,biological_process positive regulation of lamellipodium assembly;GO:0010810,biological_process regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0019887,molecular_function protein kinase regulator activity;GO:0030027,cellular_component lamellipodium;GO:0030031,biological_process cell projection assembly;GO:0030036,biological_process actin cytoskeleton organization;GO:0030168,biological_process platelet activation;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0042129,biological_process regulation of T cell proliferation;GO:0043304,biological_process regulation of mast cell degranulation;GO:0045453,biological_process bone resorption;GO:0045859,biological_process regulation of protein kinase activity;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0060263,biological_process regulation of respiratory burst;GO:0060753,biological_process regulation of mast cell chemotaxis;GO:0070062,cellular_component extracellular exosome;GO:0071593,biological_process lymphocyte aggregation;GO:0090023,biological_process positive regulation of neutrophil chemotaxis;GO:1902622,biological_process regulation of neutrophil migration;GO:1903955,biological_process positive regulation of protein targeting to mitochondrion	RAC2; Ras-related C3 botulinum toxin substrate 2; K07860	ras-related C3 botulinum toxin substrate 2 (rho family%2C small GTP binding protein Rac2) [Source:HGNC Symbol%3BAcc:HGNC:9802]
ENSG00000135632	22.97	24.42	27.65	24.46	26.29	24.86	0.00177858314926881	5.04395305602945	0.996966447541632	1	2:73214221-73227237:+	SMYD5	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0008150,biological_process biological_process;GO:0008168,molecular_function methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0032259,biological_process methylation;GO:0046872,molecular_function metal ion binding	NA	SMYD family member 5 [Source:HGNC Symbol%3BAcc:HGNC:16258]
ENSG00000062582	106.29	108.16	91.82	110.14	95.98	102.60	-0.00216795046440777	5.68641830435559	0.997351698063299	1	7:43866557-43869893:-	MRPS24	13;GO:0003723,molecular_function RNA binding;GO:0003735,molecular_function structural constituent of ribosome;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005761,cellular_component mitochondrial ribosome;GO:0005763,cellular_component mitochondrial small ribosomal subunit;GO:0005840,cellular_component ribosome;GO:0006412,biological_process translation;GO:0008150,biological_process biological_process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0032543,biological_process mitochondrial translation;GO:0070125,biological_process mitochondrial translational elongation;GO:0070126,biological_process mitochondrial translational termination	NA	mitochondrial ribosomal protein S24 [Source:HGNC Symbol%3BAcc:HGNC:14510]
ENSG00000160818	21.01	20.63	19.10	18.94	21.21	20.98	0.000971316053869572	4.66032450224923	0.99742941748522	1	1:156594486-156601496:-	GPATCH4	2;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0003676,molecular_function nucleic acid binding	NA	G-patch domain containing 4 [Source:HGNC Symbol%3BAcc:HGNC:25982]
ENSG00000165733	18.58	18.64	18.39	17.89	18.30	19.89	-0.00127555705654037	6.16583767647032	0.997436681602798	1	10:42782800-42834937:+	BMS1	15;GO:0000166,molecular_function nucleotide binding;GO:0000462,biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479,biological_process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0003723,molecular_function RNA binding;GO:0003924,molecular_function GTPase activity;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0006364,biological_process rRNA processing;GO:0030686,cellular_component 90S preribosome;GO:0034511,molecular_function U3 snoRNA binding;GO:0042254,biological_process ribosome biogenesis;GO:0042255,biological_process ribosome assembly	BMS1; ribosome biogenesis protein BMS1; K14569	BMS1%2C ribosome biogenesis factor [Source:HGNC Symbol%3BAcc:HGNC:23505]
ENSG00000141349	62.60	67.33	64.75	66.30	68.32	61.45	0.000140346846923671	6.08356418606418	0.997572861713283	1	17:44070734-44076344:+	G6PC3	12;GO:0004346,molecular_function glucose-6-phosphatase activity;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006094,biological_process gluconeogenesis;GO:0006796,biological_process phosphate-containing compound metabolic process;GO:0015760,biological_process glucose-6-phosphate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0051156,biological_process glucose 6-phosphate metabolic process	G6PC; glucose-6-phosphatase [EC:3.1.3.9]; K01084	glucose-6-phosphatase catalytic subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:24861]
ENSG00000012817	7.59	7.37	7.22	7.06	8.15	7.14	0.00190342574554704	5.13390279717632	0.997751678782355	1	Y:19703864-19744939:-	KDM5D	18;GO:0002457,biological_process T cell antigen processing and presentation;GO:0003677,molecular_function DNA binding;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016491,molecular_function oxidoreductase activity;GO:0016569,biological_process covalent chromatin modification;GO:0016706,molecular_function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0032452,molecular_function histone demethylase activity;GO:0032453,molecular_function histone demethylase activity (H3-K4 specific);GO:0034720,biological_process histone H3-K4 demethylation;GO:0046872,molecular_function metal ion binding;GO:0050681,molecular_function androgen receptor binding;GO:0051213,molecular_function dioxygenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0060765,biological_process regulation of androgen receptor signaling pathway	NA	lysine demethylase 5D [Source:HGNC Symbol%3BAcc:HGNC:11115]
ENSG00000155561	19.47	19.61	18.88	19.33	19.36	19.72	0.000169557454463421	6.88830890054623	0.997764758263685	1	7:135557918-135648757:+	NUP205	25;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005643,cellular_component nuclear pore;GO:0006110,biological_process regulation of glycolytic process;GO:0006406,biological_process mRNA export from nucleus;GO:0006409,biological_process tRNA export from nucleus;GO:0006810,biological_process transport;GO:0006913,biological_process nucleocytoplasmic transport;GO:0007077,biological_process mitotic nuclear envelope disassembly;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016032,biological_process viral process;GO:0016925,biological_process protein sumoylation;GO:0017056,molecular_function structural constituent of nuclear pore;GO:0019083,biological_process viral transcription;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0043657,cellular_component host cell;GO:0044611,cellular_component nuclear pore inner ring;GO:0051028,biological_process mRNA transport;GO:0051292,biological_process nuclear pore complex assembly;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:0075733,biological_process intracellular transport of virus;GO:1900034,biological_process regulation of cellular response to heat	NUP205, NUP192; nuclear pore complex protein Nup205; K14310	nucleoporin 205 [Source:HGNC Symbol%3BAcc:HGNC:18658]
ENSG00000101193	50.49	48.06	42.40	49.26	45.02	47.91	-0.0019102463015288	5.01985790611226	0.997787486279133	1	20:62938118-62948475:+	GID8	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0030054,cellular_component cell junction	NA	GID complex subunit 8 homolog [Source:HGNC Symbol%3BAcc:HGNC:15857]
ENSG00000127838	25.95	25.28	24.41	25.21	24.72	26.37	-0.00150708199344512	5.31517874611737	0.997803739570946	1	2:218270391-218346793:+	PNKD	13;GO:0004416,molecular_function hydroxyacylglutathione hydrolase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0016020,cellular_component membrane;GO:0016787,molecular_function hydrolase activity;GO:0019243,biological_process methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0032225,biological_process regulation of synaptic transmission, dopaminergic;GO:0042053,biological_process regulation of dopamine metabolic process;GO:0046872,molecular_function metal ion binding;GO:0046929,biological_process negative regulation of neurotransmitter secretion;GO:0050884,biological_process neuromuscular process controlling posture	NA	paroxysmal nonkinesigenic dyskinesia [Source:HGNC Symbol%3BAcc:HGNC:9153]
ENSG00000213719	688.38	762.94	663.53	719.00	708.81	703.76	-3.23679627082752e-05	9.00033689970121	0.997934964987309	1	6:31730580-31739763:-	CLIC1	29;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005254,molecular_function chloride channel activity;GO:0005515,molecular_function protein binding;GO:0005615,cellular_component extracellular space;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0005903,cellular_component brush border;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006821,biological_process chloride transport;GO:0007165,biological_process signal transduction;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0031965,cellular_component nuclear membrane;GO:0031982,cellular_component vesicle;GO:0034707,cellular_component chloride channel complex;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0045296,molecular_function cadherin binding;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051726,biological_process regulation of cell cycle;GO:0051881,biological_process regulation of mitochondrial membrane potential;GO:0070062,cellular_component extracellular exosome;GO:0070527,biological_process platelet aggregation;GO:0072562,cellular_component blood microparticle;GO:1902476,biological_process chloride transmembrane transport	NA	chloride intracellular channel 1 [Source:HGNC Symbol%3BAcc:HGNC:2062]
ENSG00000181481	19.66	20.54	20.24	19.80	19.79	21.35	-0.00302713503096396	4.86556379838778	0.99814834651474	1	17:30968784-30999911:+	RNF135	15;GO:0002376,biological_process immune system process;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016567,biological_process protein ubiquitination;GO:0016579,biological_process protein deubiquitination;GO:0016740,molecular_function transferase activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032728,biological_process positive regulation of interferon-beta production;GO:0042802,molecular_function identical protein binding;GO:0043021,molecular_function ribonucleoprotein complex binding;GO:0045087,biological_process innate immune response;GO:0045088,biological_process regulation of innate immune response;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 135 [Source:HGNC Symbol%3BAcc:HGNC:21158]
ENSG00000142197	12.09	13.25	11.82	12.78	12.32	12.34	-0.00189546569997423	6.42400318366691	0.998149283529832	1	21:36156781-36294274:+	DOPEY2	12;GO:0000139,cellular_component Golgi membrane;GO:0003674,molecular_function molecular_function;GO:0005768,cellular_component endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007275,biological_process multicellular organism development;GO:0015031,biological_process protein transport;GO:0050890,biological_process cognition;GO:0070062,cellular_component extracellular exosome	NA	dopey family member 2 [Source:HGNC Symbol%3BAcc:HGNC:1291]
ENSG00000131174	239.54	231.75	202.40	222.43	258.18	198.06	0.00104102686052683	5.76129403166048	0.998449380046425	1	X:77899437-77907373:+	COX7B	10;GO:0004129,molecular_function cytochrome-c oxidase activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005746,cellular_component mitochondrial respiratory chain;GO:0006123,biological_process mitochondrial electron transport, cytochrome c to oxygen;GO:0007417,biological_process central nervous system development;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0045277,cellular_component respiratory chain complex IV;GO:1902600,biological_process hydrogen ion transmembrane transport	COX7B; cytochrome c oxidase subunit 7b; K02271	cytochrome c oxidase subunit 7B [Source:HGNC Symbol%3BAcc:HGNC:2291]
ENSG00000136950	62.32	54.97	58.37	61.33	58.82	57.45	0.00130961971846034	4.76702634297162	0.998454370060464	1	9:124862129-124877733:+	ARPC5L	14;GO:0003674,molecular_function molecular_function;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005885,cellular_component Arp2/3 protein complex;GO:0005925,cellular_component focal adhesion;GO:0008150,biological_process biological_process;GO:0015629,cellular_component actin cytoskeleton;GO:0016477,biological_process cell migration;GO:0030833,biological_process regulation of actin filament polymerization;GO:0034314,biological_process Arp2/3 complex-mediated actin nucleation;GO:0051015,molecular_function actin filament binding;GO:0070062,cellular_component extracellular exosome	ARPC5; actin related protein 2/3 complex, subunit 5; K05754	actin related protein 2/3 complex subunit 5 like [Source:HGNC Symbol%3BAcc:HGNC:23366]
ENSG00000148358	42.95	44.29	43.37	45.61	40.70	45.37	-0.00123630853888281	6.30474704337572	0.998565548054907	1	9:130053425-130140169:+	GPR107	8;GO:0005654,cellular_component nucleoplasm;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0032050,molecular_function clathrin heavy chain binding;GO:0072583,biological_process clathrin-mediated endocytosis	NA	G protein-coupled receptor 107 [Source:HGNC Symbol%3BAcc:HGNC:17830]
ENSG00000147454	71.02	62.85	71.89	71.05	62.90	73.58	0.00171719231819773	6.21989091318753	0.998699221469702	1	8:23528804-23575463:+	SLC25A37	11;GO:0005381,molecular_function iron ion transmembrane transporter activity;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034755,biological_process iron ion transmembrane transport;GO:0048250,biological_process mitochondrial iron ion transport;GO:0055072,biological_process iron ion homeostasis	NA	solute carrier family 25 member 37 [Source:HGNC Symbol%3BAcc:HGNC:29786]
ENSG00000179151	15.53	16.61	14.65	16.19	14.53	16.41	-0.00443595447281323	4.67943098890503	0.998703855601608	1	15:74630557-74696292:-	EDC3	13;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0003723,molecular_function RNA binding;GO:0003729,molecular_function mRNA binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0031087,biological_process deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0033962,biological_process cytoplasmic mRNA processing body assembly;GO:0042802,molecular_function identical protein binding;GO:0043928,biological_process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0090502,biological_process RNA phosphodiester bond hydrolysis, endonucleolytic;GO:1990174,molecular_function phosphodiesterase decapping endonuclease activity	EDC3; enhancer of mRNA-decapping protein 3; K12615	enhancer of mRNA decapping 3 [Source:HGNC Symbol%3BAcc:HGNC:26114]
ENSG00000168282	29.70	33.28	29.20	30.71	32.63	29.52	-0.00308635273846466	5.37391245626629	0.99877188977449	1	14:49620794-49623481:+	MGAT2	14;GO:0000139,cellular_component Golgi membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005795,cellular_component Golgi stack;GO:0006486,biological_process protein glycosylation;GO:0006487,biological_process protein N-linked glycosylation;GO:0008455,molecular_function alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0009311,biological_process oligosaccharide metabolic process;GO:0009312,biological_process oligosaccharide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0018279,biological_process protein N-linked glycosylation via asparagine;GO:0030246,molecular_function carbohydrate binding	MGAT2; alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.143]; K00736	mannosyl (alpha-1%2C6-)-glycoprotein beta-1%2C2-N-acetylglucosaminyltransferase [Source:HGNC Symbol%3BAcc:HGNC:7045]
ENSG00000115904	11.07	10.63	12.17	9.89	12.12	12.15	0.00168102698599194	5.5098390220658	0.999033362674408	1	2:38981395-39124345:-	SOS1	47;GO:0000165,biological_process MAPK cascade;GO:0001782,biological_process B cell homeostasis;GO:0001942,biological_process hair follicle development;GO:0002260,biological_process lymphocyte homeostasis;GO:0003007,biological_process heart morphogenesis;GO:0003209,biological_process cardiac atrium morphogenesis;GO:0003344,biological_process pericardium morphogenesis;GO:0003677,molecular_function DNA binding;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007173,biological_process epidermal growth factor receptor signaling pathway;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0007265,biological_process Ras protein signal transduction;GO:0007296,biological_process vitellogenesis;GO:0007411,biological_process axon guidance;GO:0008286,biological_process insulin receptor signaling pathway;GO:0014069,cellular_component postsynaptic density;GO:0017124,molecular_function SH3 domain binding;GO:0033081,biological_process regulation of T cell differentiation in thymus;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035264,biological_process multicellular organism growth;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0038128,biological_process ERBB2 signaling pathway;GO:0042129,biological_process regulation of T cell proliferation;GO:0043025,cellular_component neuronal cell body;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045742,biological_process positive regulation of epidermal growth factor receptor signaling pathway;GO:0046982,molecular_function protein heterodimerization activity;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0048514,biological_process blood vessel morphogenesis;GO:0050900,biological_process leukocyte migration;GO:0051056,biological_process regulation of small GTPase mediated signal transduction;GO:0051057,biological_process positive regulation of small GTPase mediated signal transduction;GO:0060021,biological_process palate development;GO:0061029,biological_process eyelid development in camera-type eye;GO:0061384,biological_process heart trabecula morphogenesis;GO:1904693,biological_process midbrain morphogenesis;GO:2000973,biological_process regulation of pro-B cell differentiation	SOS; son of sevenless; K03099	SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:HGNC Symbol%3BAcc:HGNC:11187]
ENSG00000010803	26.43	24.71	28.81	27.92	23.85	28.94	0.000152302435994497	5.8144570217062	0.999767079416721	1	1:41027199-41242154:-	SCMH1	15;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006338,biological_process chromatin remodeling;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0010369,cellular_component chromocenter;GO:0016458,biological_process gene silencing;GO:0045892,biological_process negative regulation of transcription, DNA-templated	NA	sex comb on midleg homolog 1 (Drosophila) [Source:HGNC Symbol%3BAcc:HGNC:19003]
ENSG00000083312	20.89	19.47	19.29	19.68	20.33	20.20	3.60316893549971e-05	5.75552288410572	0.999831824941431	1	5:72816311-72916733:+	TNPO1	21;GO:0000060,biological_process protein import into nucleus, translocation;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0006607,biological_process NLS-bearing protein import into nucleus;GO:0006610,biological_process ribosomal protein import into nucleus;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0008139,molecular_function nuclear localization sequence binding;GO:0008536,molecular_function Ran GTPase binding;GO:0008565,molecular_function protein transporter activity;GO:0015031,biological_process protein transport;GO:0016032,biological_process viral process;GO:0031965,cellular_component nuclear membrane;GO:0034399,cellular_component nuclear periphery;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0043488,biological_process regulation of mRNA stability;GO:0070062,cellular_component extracellular exosome	NA	transportin 1 [Source:HGNC Symbol%3BAcc:HGNC:6401]
ENSG00000104859	16.28	16.17	18.19	16.19	16.44	18.42	0.00132997880286085	5.16450184567094	0.999996456092057	1	19:45039039-45070956:+	CLASRP	4;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing	NA	CLK4 associating serine/arginine rich protein [Source:HGNC Symbol%3BAcc:HGNC:17731]
ENSG00000085365	14.50	13.11	13.77	13.60	12.67	15.58	-0.00305996345491418	3.95137633553071	0.999999999999998	1	5:78360582-78479071:+	SCAMP1	18;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0006892,biological_process post-Golgi vesicle-mediated transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0030672,cellular_component synaptic vesicle membrane;GO:0035579,cellular_component specific granule membrane;GO:0042589,cellular_component zymogen granule membrane;GO:0043312,biological_process neutrophil degranulation;GO:0045202,cellular_component synapse;GO:0055038,cellular_component recycling endosome membrane	NA	secretory carrier membrane protein 1 [Source:HGNC Symbol%3BAcc:HGNC:10563]
ENSG00000171045	7.92	6.79	8.61	7.25	8.32	7.97	0.00830697234009368	3.69504155162349	0.999999999999999	1	8:142212079-142403240:-	TSNARE1	10;GO:0000149,molecular_function SNARE binding;GO:0005484,molecular_function SNAP receptor activity;GO:0006886,biological_process intracellular protein transport;GO:0006906,biological_process vesicle fusion;GO:0012505,cellular_component endomembrane system;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0031201,cellular_component SNARE complex;GO:0048278,biological_process vesicle docking	NA	t-SNARE domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26437]
ENSG00000152147	14.95	16.18	12.68	13.88	15.17	14.88	-0.00115976439657611	3.34259552711133	0.999999999999999	1	2:38751533-38785000:+	GEMIN6	15;GO:0000245,biological_process spliceosomal complex assembly;GO:0000387,biological_process spliceosomal snRNP assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0016604,cellular_component nuclear body;GO:0032797,cellular_component SMN complex;GO:0034719,cellular_component SMN-Sm protein complex;GO:0051170,biological_process nuclear import;GO:0097504,cellular_component Gemini of coiled bodies	GEMIN6, SIP2; gem associated protein 6; K13134	gem nuclear organelle associated protein 6 [Source:HGNC Symbol%3BAcc:HGNC:20044]
ENSG00000170166	6.19	3.75	5.58	4.99	5.95	4.87	0.0106099412321038	2.06601356434631	0.999999999999999	1	2:176151221-176153226:+	HOXD4	16;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007275,biological_process multicellular organism development;GO:0009952,biological_process anterior/posterior pattern specification;GO:0030054,cellular_component cell junction;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048704,biological_process embryonic skeletal system morphogenesis;GO:0048863,biological_process stem cell differentiation	NA	homeobox D4 [Source:HGNC Symbol%3BAcc:HGNC:5138]
ENSG00000176058	4.01	4.74	4.65	4.56	4.89	4.00	0.00300201111707645	3.3285743402863	0.999999999999999	1	9:137191616-137204193:-	TPRN	6;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0007605,biological_process sensory perception of sound;GO:0019902,molecular_function phosphatase binding;GO:0032420,cellular_component stereocilium;GO:0042995,cellular_component cell projection	NA	taperin [Source:HGNC Symbol%3BAcc:HGNC:26894]
ENSG00000178115	0.97	1.21	1.51	1.26	1.00	1.48	-0.0161873335017901	1.32637444829301	0.999999999999999	1	15:30552077-30562501:+	GOLGA8Q	1;GO:0005794,cellular_component Golgi apparatus	NA	golgin A8 family member Q [Source:HGNC Symbol%3BAcc:HGNC:44408]
ENSG00000139971	3.47	3.40	2.68	2.38	3.89	3.40	-0.00777565721191301	2.94561042936278	0.999999999999999	1	14:57999734-58298139:-	C14orf37	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 14 open reading frame 37 [Source:HGNC Symbol%3BAcc:HGNC:19846]
ENSG00000049769	1.93	2.34	2.57	2.26	2.23	2.38	0.00390991608277173	2.54322675622063	0.999999999999999	1	X:49269842-49301461:+	PPP1R3F	6;GO:0005979,biological_process regulation of glycogen biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019903,molecular_function protein phosphatase binding;GO:2000465,biological_process regulation of glycogen (starch) synthase activity;GO:2001069,molecular_function glycogen binding	PPP1R3F, R3F; protein phosphatase 1 regulatory subunit 3F; K17453	protein phosphatase 1 regulatory subunit 3F [Source:HGNC Symbol%3BAcc:HGNC:14944]
ENSG00000198824	7.51	7.02	6.07	7.07	7.07	6.67	-0.00223126644959174	4.08458816041598	0.999999999999999	1	13:114314512-114327328:+	CHAMP1	18;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0000793,cellular_component condensed chromosome;GO:0003676,molecular_function nucleic acid binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005856,cellular_component cytoskeleton;GO:0016604,cellular_component nuclear body;GO:0031134,biological_process sister chromatid biorientation;GO:0034501,biological_process protein localization to kinetochore;GO:0035372,biological_process protein localization to microtubule;GO:0046872,molecular_function metal ion binding;GO:0051315,biological_process attachment of mitotic spindle microtubules to kinetochore	NA	chromosome alignment maintaining phosphoprotein 1 [Source:HGNC Symbol%3BAcc:HGNC:20311]
ENSG00000169249	5.96	5.28	6.47	5.96	5.27	6.68	0.000597252196170744	3.34963230750524	0.999999999999999	1	X:15790471-15823260:+	ZRSR2	15;GO:0000245,biological_process spliceosomal complex assembly;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005681,cellular_component spliceosomal complex;GO:0005689,cellular_component U12-type spliceosomal complex;GO:0006397,biological_process mRNA processing;GO:0008380,biological_process RNA splicing;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030628,molecular_function pre-mRNA 3'-splice site binding;GO:0046872,molecular_function metal ion binding;GO:0089701,cellular_component U2AF	NA	zinc finger CCCH-type%2C RNA binding motif and serine/arginine rich 2 [Source:HGNC Symbol%3BAcc:HGNC:23019]
ENSG00000085514	1.06	1.12	1.34	1.12	0.89	1.58	-0.0243582031202262	0.340743595751146	0.999999999999999	1	7:100367529-100400099:+	PILRA	11;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007169,biological_process transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016032,biological_process viral process;GO:0042288,molecular_function MHC class I protein binding;GO:0050776,biological_process regulation of immune response;GO:0070062,cellular_component extracellular exosome	PILRA; paired immunoglobulin-like type 2 receptor alpha; K15411	paired immunoglobin like type 2 receptor alpha [Source:HGNC Symbol%3BAcc:HGNC:20396]
ENSG00000006625	14.71	19.78	16.25	17.37	16.01	17.58	-0.00847805448191077	3.62073772918677	0.999999999999999	1	7:30496620-30504844:-	GGCT	8;GO:0001836,biological_process release of cytochrome c from mitochondria;GO:0003839,molecular_function gamma-glutamylcyclotransferase activity;GO:0005829,cellular_component cytosol;GO:0006750,biological_process glutathione biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0042803,molecular_function protein homodimerization activity;GO:0070062,cellular_component extracellular exosome	GGCT; gamma-glutamylcyclotransferase [EC:4.3.2.9]; K00682	gamma-glutamylcyclotransferase [Source:HGNC Symbol%3BAcc:HGNC:21705]
ENSG00000159899	1.05	0.85	1.17	1.31	1.08	0.76	-0.00608696880414367	1.77901940193793	0.999999999999999	1	9:35792153-35809732:+	NPR2	31;GO:0000166,molecular_function nucleotide binding;GO:0001503,biological_process ossification;GO:0004383,molecular_function guanylate cyclase activity;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006182,biological_process cGMP biosynthetic process;GO:0006468,biological_process protein phosphorylation;GO:0007168,biological_process receptor guanylyl cyclase signaling pathway;GO:0008074,cellular_component guanylate cyclase complex, soluble;GO:0008217,biological_process regulation of blood pressure;GO:0009190,biological_process cyclic nucleotide biosynthetic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016829,molecular_function lyase activity;GO:0016849,molecular_function phosphorus-oxygen lyase activity;GO:0016941,molecular_function natriuretic peptide receptor activity;GO:0017046,molecular_function peptide hormone binding;GO:0035556,biological_process intracellular signal transduction;GO:0042562,molecular_function hormone binding;GO:0042802,molecular_function identical protein binding;GO:0044702,biological_process single organism reproductive process;GO:0051447,biological_process negative regulation of meiotic cell cycle;GO:0060348,biological_process bone development;GO:0097011,biological_process cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1900194,biological_process negative regulation of oocyte maturation;GO:1903779,biological_process regulation of cardiac conduction	NA	natriuretic peptide receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:7944]
ENSG00000155621	19.85	18.18	18.53	19.90	16.12	20.85	0.00486447760191155	3.77648194242115	0.999999999999999	1	9:71911509-71986054:+	C9orf85	NA	NA	chromosome 9 open reading frame 85 [Source:HGNC Symbol%3BAcc:HGNC:28784]
ENSG00000176261	31.38	28.84	26.37	29.99	30.49	26.68	0.00450837628647951	4.37095134034105	0.999999999999999	1	1:32600171-32650903:-	ZBTB8OS	6;GO:0005654,cellular_component nucleoplasm;GO:0006388,biological_process tRNA splicing, via endonucleolytic cleavage and ligation;GO:0008033,biological_process tRNA processing;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0072669,cellular_component tRNA-splicing ligase complex	NA	zinc finger and BTB domain containing 8 opposite strand [Source:HGNC Symbol%3BAcc:HGNC:24094]
ENSG00000163686	10.48	10.15	11.76	10.53	11.39	10.90	-0.00266942548643362	3.52781404616389	0.999999999999999	1	3:58237505-58295693:+	ABHD6	16;GO:0003824,molecular_function catalytic activity;GO:0004620,molecular_function phospholipase activity;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0009395,biological_process phospholipid catabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030336,biological_process negative regulation of cell migration;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0046464,biological_process acylglycerol catabolic process;GO:0046889,biological_process positive regulation of lipid biosynthetic process;GO:0047372,molecular_function acylglycerol lipase activity;GO:0060292,biological_process long term synaptic depression;GO:0070062,cellular_component extracellular exosome;GO:2000124,biological_process regulation of endocannabinoid signaling pathway	ABHD6; abhydrolase domain-containing protein 6 [EC:3.1.1.23]; K13700	abhydrolase domain containing 6 [Source:HGNC Symbol%3BAcc:HGNC:21398]
ENSG00000008324	52.89	56.68	56.71	59.64	48.59	59.06	-0.000946923688763696	3.70021148459654	0.999999999999999	1	3:42581839-42595114:+	SS18L2	2;GO:0003713,molecular_function transcription coactivator activity;GO:1903506,biological_process regulation of nucleic acid-templated transcription	NA	SS18 like 2 [Source:HGNC Symbol%3BAcc:HGNC:15593]
ENSG00000144233	16.63	17.78	19.55	18.60	17.53	18.22	0.000775149250682762	4.08324473770145	0.999999999999999	1	2:127861629-127885922:-	AMMECR1L	NA	NA	AMMECR1 like [Source:HGNC Symbol%3BAcc:HGNC:28658]
ENSG00000213029	16.07	10.11	4.28	6.73	11.64	11.91	0.0235914024156911	1.05406592811507	1	1	1:229304856-229305504:+	SPHAR	1;GO:0006260,biological_process DNA replication	NA	S-phase response (cyclin related) [Source:HGNC Symbol%3BAcc:HGNC:16957]
ENSG00000087884	12.85	11.87	13.63	14.35	12.31	12.03	0.00550060502225353	3.58067924741806	1	1	11:77821108-77918432:+	AAMDC	5;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0043066,biological_process negative regulation of apoptotic process;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; K09008	adipogenesis associated Mth938 domain containing [Source:HGNC Symbol%3BAcc:HGNC:30205]
ENSG00000123427	9.36	7.93	8.48	9.83	7.34	8.83	0.00469295783759592	2.93914507947087	1	1	12:57771491-57782541:+	EEF1AKMT3	13;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005856,cellular_component cytoskeleton;GO:0008168,molecular_function methyltransferase activity;GO:0016279,molecular_function protein-lysine N-methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0018022,biological_process peptidyl-lysine methylation;GO:0031072,molecular_function heat shock protein binding;GO:0032259,biological_process methylation;GO:0043234,cellular_component protein complex	NA	EEF1A lysine methyltransferase 3 [Source:HGNC Symbol%3BAcc:HGNC:24936]
ENSG00000167280	6.95	6.62	7.91	7.33	6.64	7.71	0.00219576127747735	4.13200888324169	1	1	17:79074938-79088599:+	ENGASE	9;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005829,cellular_component cytosol;GO:0006457,biological_process protein folding;GO:0006517,biological_process protein deglycosylation;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0016798,molecular_function hydrolase activity, acting on glycosyl bonds;GO:0033925,molecular_function mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	E3.2.1.96; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96]; K01227	endo-beta-N-acetylglucosaminidase [Source:HGNC Symbol%3BAcc:HGNC:24622]
ENSG00000137486	7.93	7.11	8.32	7.57	7.50	8.59	-0.00122478973752577	3.5058678693552	1	1	11:75264181-75351705:-	ARRB1	85;GO:0000139,cellular_component Golgi membrane;GO:0000187,biological_process activation of MAPK activity;GO:0000785,cellular_component chromatin;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002031,biological_process G-protein coupled receptor internalization;GO:0002092,biological_process positive regulation of receptor internalization;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005096,molecular_function GTPase activator activity;GO:0005159,molecular_function insulin-like growth factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005765,cellular_component lysosomal membrane;GO:0005829,cellular_component cytosol;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006810,biological_process transport;GO:0006897,biological_process endocytosis;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007602,biological_process phototransduction;GO:0008134,molecular_function transcription factor binding;GO:0008277,biological_process regulation of G-protein coupled receptor protein signaling pathway;GO:0009968,biological_process negative regulation of signal transduction;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0016567,biological_process protein ubiquitination;GO:0016604,cellular_component nuclear body;GO:0030168,biological_process platelet activation;GO:0030331,molecular_function estrogen receptor binding;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031143,cellular_component pseudopodium;GO:0031397,biological_process negative regulation of protein ubiquitination;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031691,molecular_function alpha-1A adrenergic receptor binding;GO:0031692,molecular_function alpha-1B adrenergic receptor binding;GO:0031701,molecular_function angiotensin receptor binding;GO:0031762,molecular_function follicle-stimulating hormone receptor binding;GO:0031896,molecular_function V2 vasopressin receptor binding;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032092,biological_process positive regulation of protein binding;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032717,biological_process negative regulation of interleukin-8 production;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034260,biological_process negative regulation of GTPase activity;GO:0034393,biological_process positive regulation of smooth muscle cell apoptotic process;GO:0035025,biological_process positive regulation of Rho protein signal transduction;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035612,molecular_function AP-2 adaptor complex binding;GO:0035615,molecular_function clathrin adaptor activity;GO:0035774,biological_process positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042493,biological_process response to drug;GO:0042699,biological_process follicle-stimulating hormone signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0042995,cellular_component cell projection;GO:0043027,molecular_function cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0043149,biological_process stress fiber assembly;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043197,cellular_component dendritic spine;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043547,biological_process positive regulation of GTPase activity;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0044325,molecular_function ion channel binding;GO:0045211,cellular_component postsynaptic membrane;GO:0045309,molecular_function protein phosphorylated amino acid binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0051219,molecular_function phosphoprotein binding;GO:0061024,biological_process membrane organization;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0090240,biological_process positive regulation of histone H4 acetylation	ARRB; beta-arrestin; K04439	arrestin beta 1 [Source:HGNC Symbol%3BAcc:HGNC:711]
ENSG00000111846	2.77	3.11	3.03	2.84	3.24	2.87	5.55052725630606e-05	3.24340188284278	1	1	6:10492222-10629368:+	GCNT2	22;GO:0000139,cellular_component Golgi membrane;GO:0005575,cellular_component cellular_component;GO:0005794,cellular_component Golgi apparatus;GO:0006024,biological_process glycosaminoglycan biosynthetic process;GO:0006486,biological_process protein glycosylation;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0008109,molecular_function N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0010718,biological_process positive regulation of epithelial to mesenchymal transition;GO:0010812,biological_process negative regulation of cell-substrate adhesion;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0030335,biological_process positive regulation of cell migration;GO:0034116,biological_process positive regulation of heterotypic cell-cell adhesion;GO:0036438,biological_process maintenance of lens transparency;GO:0051897,biological_process positive regulation of protein kinase B signaling;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade	GCNT2; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase [EC:2.4.1.150]; K00742	glucosaminyl (N-acetyl) transferase 2%2C I-branching enzyme (I blood group) [Source:HGNC Symbol%3BAcc:HGNC:4204]
ENSG00000163431	0.59	0.21	0.61	0.37	0.46	0.55	0.0939516641735569	0.0180980257237736	1	1	1:201896451-201946588:-	LMOD1	15;GO:0003779,molecular_function actin binding;GO:0005523,molecular_function tropomyosin binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005865,cellular_component striated muscle thin filament;GO:0005884,cellular_component actin filament;GO:0006936,biological_process muscle contraction;GO:0016020,cellular_component membrane;GO:0030016,cellular_component myofibril;GO:0030017,cellular_component sarcomere;GO:0030239,biological_process myofibril assembly;GO:0030838,biological_process positive regulation of actin filament polymerization;GO:0045010,biological_process actin nucleation;GO:0051694,biological_process pointed-end actin filament capping	NA	leiomodin 1 [Source:HGNC Symbol%3BAcc:HGNC:6647]
ENSG00000262246	0.22	0.24	0.35	0.28	0.36	0.20	-0.0232502160033837	0.0371818124540159	1	1	16:4354541-4425705:-	CORO7	14;GO:0000139,cellular_component Golgi membrane;GO:0003779,molecular_function actin binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030041,biological_process actin filament polymerization;GO:0031410,cellular_component cytoplasmic vesicle	NA	coronin 7 [Source:HGNC Symbol%3BAcc:HGNC:26161]
ENSG00000119559	5.34	6.93	5.78	6.48	6.33	5.45	-0.0177546848960322	2.63310647015933	1	1	19:1461142-1479556:-	C19orf25	1;GO:0005515,molecular_function protein binding	NA	chromosome 19 open reading frame 25 [Source:HGNC Symbol%3BAcc:HGNC:26711]
ENSG00000129317	4.70	6.27	4.83	4.91	5.55	5.42	-0.0102265833125838	3.48521305009742	1	1	12:43718992-43758817:-	PUS7L	7;GO:0001522,biological_process pseudouridine synthesis;GO:0003723,molecular_function RNA binding;GO:0005515,molecular_function protein binding;GO:0008033,biological_process tRNA processing;GO:0009451,biological_process RNA modification;GO:0009982,molecular_function pseudouridine synthase activity;GO:0016853,molecular_function isomerase activity	NA	pseudouridylate synthase 7 like [Source:HGNC Symbol%3BAcc:HGNC:25276]
ENSG00000111679	1.81	2.27	1.82	1.96	2.20	1.77	-0.00969864889781451	2.06946479550019	1	1	12:6946467-6961316:+	PTPN6	59;GO:0001784,molecular_function phosphotyrosine binding;GO:0002244,biological_process hematopoietic progenitor cell differentiation;GO:0002924,biological_process negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005001,molecular_function transmembrane receptor protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005911,cellular_component cell-cell junction;GO:0006470,biological_process protein dephosphorylation;GO:0006915,biological_process apoptotic process;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0014068,biological_process positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016020,cellular_component membrane;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017124,molecular_function SH3 domain binding;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0019901,molecular_function protein kinase binding;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0030220,biological_process platelet formation;GO:0031295,biological_process T cell costimulation;GO:0033277,biological_process abortive mitotic cell cycle;GO:0033630,biological_process positive regulation of cell adhesion mediated by integrin;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0035556,biological_process intracellular signal transduction;GO:0035580,cellular_component specific granule lumen;GO:0035855,biological_process megakaryocyte development;GO:0042105,cellular_component alpha-beta T cell receptor complex;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0042169,molecular_function SH2 domain binding;GO:0042267,biological_process natural killer cell mediated cytotoxicity;GO:0043234,cellular_component protein complex;GO:0043312,biological_process neutrophil degranulation;GO:0043407,biological_process negative regulation of MAP kinase activity;GO:0043409,biological_process negative regulation of MAPK cascade;GO:0045577,biological_process regulation of B cell differentiation;GO:0050732,biological_process negative regulation of peptidyl-tyrosine phosphorylation;GO:0050839,molecular_function cell adhesion molecule binding;GO:0050853,biological_process B cell receptor signaling pathway;GO:0050859,biological_process negative regulation of B cell receptor signaling pathway;GO:0050860,biological_process negative regulation of T cell receptor signaling pathway;GO:0050900,biological_process leukocyte migration;GO:0051279,biological_process regulation of release of sequestered calcium ion into cytosol;GO:0060338,biological_process regulation of type I interferon-mediated signaling pathway;GO:0070062,cellular_component extracellular exosome;GO:0070372,biological_process regulation of ERK1 and ERK2 cascade;GO:0070527,biological_process platelet aggregation;GO:1904724,cellular_component tertiary granule lumen;GO:2000045,biological_process regulation of G1/S transition of mitotic cell cycle	PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]; K05697	protein tyrosine phosphatase%2C non-receptor type 6 [Source:HGNC Symbol%3BAcc:HGNC:9658]
ENSG00000187583	4.86	4.13	5.92	4.71	4.96	5.41	0.00688132277450697	3.34379521386799	1	1	1:966496-975865:+	PLEKHN1	3;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane	NA	pleckstrin homology domain containing N1 [Source:HGNC Symbol%3BAcc:HGNC:25284]
ENSG00000168256	30.54	25.30	24.67	25.63	28.73	26.84	0.00483813142147697	4.27293337158384	1	1	17:42011381-42025644:+	NKIRAS2	8;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005575,cellular_component cellular_component;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0007249,biological_process I-kappaB kinase/NF-kappaB signaling;GO:0016020,cellular_component membrane	NA	NFKB inhibitor interacting Ras like 2 [Source:HGNC Symbol%3BAcc:HGNC:17898]
ENSG00000172889	16.30	15.87	16.09	18.28	15.37	14.94	0.00381813337335944	3.7418956287076	1	1	9:136658855-136672678:+	EGFL7	12;GO:0001525,biological_process angiogenesis;GO:0001568,biological_process blood vessel development;GO:0001570,biological_process vasculogenesis;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0007155,biological_process cell adhesion;GO:0007275,biological_process multicellular organism development;GO:0030154,biological_process cell differentiation;GO:0031012,cellular_component extracellular matrix;GO:0045746,biological_process negative regulation of Notch signaling pathway	NA	EGF like domain multiple 7 [Source:HGNC Symbol%3BAcc:HGNC:20594]
ENSG00000162148	4.03	4.11	5.40	4.27	4.67	4.80	-0.00365007056540777	2.65646975540372	1	1	11:61481119-61490931:+	PPP1R32	2;GO:0005515,molecular_function protein binding;GO:0019902,molecular_function phosphatase binding	NA	protein phosphatase 1 regulatory subunit 32 [Source:HGNC Symbol%3BAcc:HGNC:28869]
ENSG00000102743	4.30	5.08	4.65	5.64	4.12	4.28	0.00289456360091588	2.1244896339973	1	1	13:40789411-40810111:+	SLC25A15	10;GO:0000050,biological_process urea cycle;GO:0000064,molecular_function L-ornithine transmembrane transporter activity;GO:0000066,biological_process mitochondrial ornithine transport;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:1903352,biological_process L-ornithine transmembrane transport	NA	solute carrier family 25 member 15 [Source:HGNC Symbol%3BAcc:HGNC:10985]
ENSG00000168404	8.00	8.35	8.14	7.92	7.77	8.88	0.00274496476107483	3.60110713021889	1	1	16:74671854-74700960:-	MLKL	16;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0012501,biological_process programmed cell death;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0032403,molecular_function protein complex binding;GO:0035556,biological_process intracellular signal transduction;GO:0070207,biological_process protein homotrimerization;GO:0070266,biological_process necroptotic process	MLKL; mixed lineage kinase domain-like [EC:2.7.11.1]; K08849	mixed lineage kinase domain like pseudokinase [Source:HGNC Symbol%3BAcc:HGNC:26617]
ENSG00000146373	4.13	4.79	5.43	5.17	4.44	4.82	0.0018749077833088	3.20944085273464	1	1	6:124962544-125092633:+	RNF217	14;GO:0000151,cellular_component ubiquitin ligase complex;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0031624,molecular_function ubiquitin conjugating enzyme binding;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity	NA	ring finger protein 217 [Source:HGNC Symbol%3BAcc:HGNC:21487]
ENSG00000106688	11.13	12.39	9.91	10.23	12.29	11.03	-0.000294678029032425	4.14394627522649	1	1	9:4490443-4587469:+	SLC1A1	34;GO:0005313,molecular_function L-glutamate transmembrane transporter activity;GO:0005314,molecular_function high-affinity glutamate transmembrane transporter activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006865,biological_process amino acid transport;GO:0007268,biological_process chemical synaptic transmission;GO:0010460,biological_process positive regulation of heart rate;GO:0014047,biological_process glutamate secretion;GO:0015108,molecular_function chloride transmembrane transporter activity;GO:0015171,molecular_function amino acid transmembrane transporter activity;GO:0015293,molecular_function symporter activity;GO:0015501,molecular_function glutamate:sodium symporter activity;GO:0015813,biological_process L-glutamate transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016595,molecular_function glutamate binding;GO:0033229,molecular_function cysteine transmembrane transporter activity;GO:0042883,biological_process cysteine transport;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization;GO:0051938,biological_process L-glutamate import;GO:0055085,biological_process transmembrane transport;GO:0070062,cellular_component extracellular exosome;GO:0070779,biological_process D-aspartate import;GO:0089711,biological_process L-glutamate transmembrane transport;GO:0098712,biological_process L-glutamate import across plasma membrane;GO:0140009,biological_process L-aspartate import across plasma membrane;GO:0140016,biological_process D-aspartate import across plasma membrane;GO:1902476,biological_process chloride transmembrane transport;GO:1903712,biological_process cysteine transmembrane transport	SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1; K05612	solute carrier family 1 member 1 [Source:HGNC Symbol%3BAcc:HGNC:10939]
ENSG00000164879	2.26	1.35	2.08	1.34	2.24	2.07	0.0491056567890347	0.71863144780113	1	1	8:85373435-85449040:+	CA3	13;GO:0004089,molecular_function carbonate dehydratase activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006730,biological_process one-carbon metabolic process;GO:0006979,biological_process response to oxidative stress;GO:0008270,molecular_function zinc ion binding;GO:0015701,biological_process bicarbonate transport;GO:0016151,molecular_function nickel cation binding;GO:0016311,biological_process dephosphorylation;GO:0016791,molecular_function phosphatase activity;GO:0016829,molecular_function lyase activity;GO:0045471,biological_process response to ethanol;GO:0046872,molecular_function metal ion binding	CA; carbonic anhydrase [EC:4.2.1.1]; K01672	carbonic anhydrase 3 [Source:HGNC Symbol%3BAcc:HGNC:1374]
ENSG00000163734	4.18	2.68	3.21	4.90	2.13	3.07	0.0312633611077003	0.311451169423793	1	1	4:74036588-74038807:-	CXCL3	15;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0008009,molecular_function chemokine activity;GO:0030593,biological_process neutrophil chemotaxis;GO:0032496,biological_process response to lipopolysaccharide;GO:0042127,biological_process regulation of cell proliferation;GO:0045236,molecular_function CXCR chemokine receptor binding;GO:0070098,biological_process chemokine-mediated signaling pathway;GO:0090023,biological_process positive regulation of neutrophil chemotaxis	CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3; K05505	C-X-C motif chemokine ligand 3 [Source:HGNC Symbol%3BAcc:HGNC:4604]
ENSG00000081052	0.21	0.19	0.23	0.25	0.18	0.22	-0.0302697353417262	0.311682175977605	1	1	2:227002710-227164113:-	COL4A4	11;GO:0005201,molecular_function extracellular matrix structural constituent;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005581,cellular_component collagen trimer;GO:0005587,cellular_component collagen type IV trimer;GO:0005604,cellular_component basement membrane;GO:0005605,cellular_component basal lamina;GO:0005788,cellular_component endoplasmic reticulum lumen;GO:0030198,biological_process extracellular matrix organization;GO:0030574,biological_process collagen catabolic process;GO:0032836,biological_process glomerular basement membrane development	COL4A; collagen, type IV, alpha; K06237	collagen type IV alpha 4 chain [Source:HGNC Symbol%3BAcc:HGNC:2206]
ENSG00000159337	0.49	0.51	0.63	0.67	0.40	0.60	-0.0298226973584614	0.591808931045365	1	1	15:42067008-42094554:-	PLA2G4D	24;GO:0004620,molecular_function phospholipase activity;GO:0004622,molecular_function lysophospholipase activity;GO:0004623,molecular_function phospholipase A2 activity;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006629,biological_process lipid metabolic process;GO:0006644,biological_process phospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008970,molecular_function phosphatidylcholine 1-acylhydrolase activity;GO:0009395,biological_process phospholipid catabolic process;GO:0016020,cellular_component membrane;GO:0016042,biological_process lipid catabolic process;GO:0016787,molecular_function hydrolase activity;GO:0030659,cellular_component cytoplasmic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0036148,biological_process phosphatidylglycerol acyl-chain remodeling;GO:0036149,biological_process phosphatidylinositol acyl-chain remodeling;GO:0036150,biological_process phosphatidylserine acyl-chain remodeling;GO:0036151,biological_process phosphatidylcholine acyl-chain remodeling;GO:0036152,biological_process phosphatidylethanolamine acyl-chain remodeling;GO:0046475,biological_process glycerophospholipid catabolic process;GO:0046872,molecular_function metal ion binding;GO:0047498,molecular_function calcium-dependent phospholipase A2 activity	PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]; K16342	phospholipase A2 group IVD [Source:HGNC Symbol%3BAcc:HGNC:30038]
ENSG00000186399	0.78	0.71	0.74	0.83	0.72	0.67	0.0254818117747714	0.639699338556641	1	1	15:30403739-30414162:-	GOLGA8R	1;GO:0005794,cellular_component Golgi apparatus	NA	golgin A8 family member R [Source:HGNC Symbol%3BAcc:HGNC:44407]
ENSG00000108176	2.62	3.30	3.71	4.37	1.51	3.92	-0.0202122179537128	1.37653294303021	1	1	10:67796664-67838166:-	DNAJC12	2;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm	NA	DnaJ heat shock protein family (Hsp40) member C12 [Source:HGNC Symbol%3BAcc:HGNC:28908]
ENSG00000160460	0.22	0.22	0.20	0.28	0.15	0.20	0.0165259320232542	0.847129523227273	1	1	19:40466240-40576464:+	SPTBN4	51;GO:0000165,biological_process MAPK cascade;GO:0002028,biological_process regulation of sodium ion transport;GO:0003779,molecular_function actin binding;GO:0005088,molecular_function Ras guanyl-nucleotide exchange factor activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005543,molecular_function phospholipid binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005912,cellular_component adherens junction;GO:0005938,cellular_component cell cortex;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0007010,biological_process cytoskeleton organization;GO:0007016,biological_process cytoskeletal anchoring at plasma membrane;GO:0007409,biological_process axonogenesis;GO:0007411,biological_process axon guidance;GO:0007605,biological_process sensory perception of sound;GO:0007628,biological_process adult walking behavior;GO:0008091,cellular_component spectrin;GO:0009566,biological_process fertilization;GO:0010459,biological_process negative regulation of heart rate;GO:0014704,cellular_component intercalated disc;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016363,cellular_component nuclear matrix;GO:0016605,cellular_component PML body;GO:0019226,biological_process transmission of nerve impulse;GO:0019902,molecular_function phosphatase binding;GO:0021952,biological_process central nervous system projection neuron axonogenesis;GO:0022414,biological_process reproductive process;GO:0030424,cellular_component axon;GO:0030506,molecular_function ankyrin binding;GO:0030507,molecular_function spectrin binding;GO:0030534,biological_process adult behavior;GO:0033135,biological_process regulation of peptidyl-serine phosphorylation;GO:0033268,cellular_component node of Ranvier;GO:0033270,cellular_component paranode region of axon;GO:0034613,biological_process cellular protein localization;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0043025,cellular_component neuronal cell body;GO:0043194,cellular_component axon initial segment;GO:0043203,cellular_component axon hillock;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045162,biological_process clustering of voltage-gated sodium channels;GO:0051693,biological_process actin filament capping;GO:0061337,biological_process cardiac conduction;GO:0070062,cellular_component extracellular exosome;GO:0070852,cellular_component cell body fiber;GO:0090002,biological_process establishment of protein localization to plasma membrane	NA	spectrin beta%2C non-erythrocytic 4 [Source:HGNC Symbol%3BAcc:HGNC:14896]
ENSG00000214189	4.28	4.58	4.60	4.03	4.52	5.09	-0.0123227389915142	2.25554094079493	1	1	19:12092262-12137235:+	ZNF788	3;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger family member 788 [Source:HGNC Symbol%3BAcc:HGNC:33112]
ENSG00000117245	0.30	0.37	0.48	0.41	0.39	0.34	0.0115023070761698	0.411647416336154	1	1	1:20664013-20718017:-	KIF17	29;GO:0000166,molecular_function nucleotide binding;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005871,cellular_component kinesin complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006810,biological_process transport;GO:0007017,biological_process microtubule-based process;GO:0007018,biological_process microtubule-based movement;GO:0008017,molecular_function microtubule binding;GO:0008574,molecular_function ATP-dependent microtubule motor activity, plus-end-directed;GO:0015031,biological_process protein transport;GO:0015630,cellular_component microtubule cytoskeleton;GO:0016192,biological_process vesicle-mediated transport;GO:0022008,biological_process neurogenesis;GO:0030030,biological_process cell projection organization;GO:0030992,cellular_component intraciliary transport particle B;GO:0031503,biological_process protein complex localization;GO:0032391,cellular_component photoreceptor connecting cilium;GO:0032839,cellular_component dendrite cytoplasm;GO:0035735,biological_process intraciliary transport involved in cilium morphogenesis;GO:0036064,cellular_component ciliary basal body;GO:0042995,cellular_component cell projection;GO:0098971,biological_process anterograde dendritic transport of neurotransmitter receptor complex;GO:1990075,cellular_component periciliary membrane compartment	KIF3A; kinesin family member 3A; K10394	kinesin family member 17 [Source:HGNC Symbol%3BAcc:HGNC:19167]
ENSG00000146197	0.73	0.67	0.52	0.85	0.61	0.50	-0.0107959778785215	1.05514725481842	1	1	6:35214418-35253079:+	SCUBE3	12;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0009986,cellular_component cell surface;GO:0022617,biological_process extracellular matrix disassembly;GO:0030154,biological_process cell differentiation;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization	NA	signal peptide%2C CUB domain and EGF like domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:13655]
ENSG00000104228	2.85	3.02	3.17	2.87	3.36	2.93	-0.00869453308031358	2.22108944965248	1	1	8:27284886-27311319:-	TRIM35	11;GO:0003674,molecular_function molecular_function;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006915,biological_process apoptotic process;GO:0008270,molecular_function zinc ion binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0045087,biological_process innate immune response;GO:0045930,biological_process negative regulation of mitotic cell cycle;GO:0046872,molecular_function metal ion binding;GO:1902187,biological_process negative regulation of viral release from host cell	NA	tripartite motif containing 35 [Source:HGNC Symbol%3BAcc:HGNC:16285]
ENSG00000203618	1.71	2.01	1.67	2.54	1.35	1.48	0.00682457203221241	0.326980710484742	1	1	22:19722944-19724771:+	GP1BB	13;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007596,biological_process blood coagulation;GO:0007597,biological_process blood coagulation, intrinsic pathway;GO:0007599,biological_process hemostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030168,biological_process platelet activation;GO:0042802,molecular_function identical protein binding	GP1BB, CD42c; platelet glycoprotein Ib beta chain; K06262	glycoprotein Ib platelet beta subunit [Source:HGNC Symbol%3BAcc:HGNC:4440]
ENSG00000160973	0.52	1.31	0.94	0.82	0.90	0.96	0.00329714085636741	0.173931828079986	1	1	8:144473411-144476335:-	FOXH1	46;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000790,cellular_component nuclear chromatin;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0001205,molecular_function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001947,biological_process heart looping;GO:0003139,biological_process secondary heart field specification;GO:0003151,biological_process outflow tract morphogenesis;GO:0003215,biological_process cardiac right ventricle morphogenesis;GO:0003222,biological_process ventricular trabecula myocardium morphogenesis;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0003705,molecular_function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007179,biological_process transforming growth factor beta receptor signaling pathway;GO:0007368,biological_process determination of left/right symmetry;GO:0009653,biological_process anatomical structure morphogenesis;GO:0009952,biological_process anterior/posterior pattern specification;GO:0019904,molecular_function protein domain specific binding;GO:0030154,biological_process cell differentiation;GO:0032444,cellular_component activin responsive factor complex;GO:0033147,biological_process negative regulation of intracellular estrogen receptor signaling pathway;GO:0035054,biological_process embryonic heart tube anterior/posterior pattern specification;GO:0035326,molecular_function enhancer binding;GO:0035909,biological_process aorta morphogenesis;GO:0043425,molecular_function bHLH transcription factor binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046332,molecular_function SMAD binding;GO:0048318,biological_process axial mesoderm development;GO:0050681,molecular_function androgen receptor binding;GO:0060766,biological_process negative regulation of androgen receptor signaling pathway;GO:0070410,molecular_function co-SMAD binding;GO:0070412,molecular_function R-SMAD binding;GO:0071345,biological_process cellular response to cytokine stimulus;GO:1900164,biological_process nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:2000824,biological_process negative regulation of androgen receptor activity	NA	forkhead box H1 [Source:HGNC Symbol%3BAcc:HGNC:3814]
ENSG00000106538	31.85	30.51	29.84	28.08	32.41	32.66	-0.0028990100270249	4.206386930184	1	1	7:150338316-150341674:-	RARRES2	25;GO:0001523,biological_process retinoid metabolic process;GO:0001701,biological_process in utero embryonic development;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002576,biological_process platelet degranulation;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006935,biological_process chemotaxis;GO:0006954,biological_process inflammatory response;GO:0010759,biological_process positive regulation of macrophage chemotaxis;GO:0019732,biological_process antifungal humoral response;GO:0030154,biological_process cell differentiation;GO:0031012,cellular_component extracellular matrix;GO:0031089,cellular_component platelet dense granule lumen;GO:0045087,biological_process innate immune response;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0048566,biological_process embryonic digestive tract development;GO:0050829,biological_process defense response to Gram-negative bacterium;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0050921,biological_process positive regulation of chemotaxis;GO:0050994,biological_process regulation of lipid catabolic process;GO:0061760,biological_process antifungal innate immune response;GO:0070062,cellular_component extracellular exosome;GO:2001275,biological_process positive regulation of glucose import in response to insulin stimulus	NA	retinoic acid receptor responder 2 [Source:HGNC Symbol%3BAcc:HGNC:9868]
ENSG00000123342	5.59	4.75	4.74	5.24	4.75	5.31	-0.00271255534657987	3.07537875981095	1	1	12:55835432-55842966:-	MMP19	22;GO:0001525,biological_process angiogenesis;GO:0001541,biological_process ovarian follicle development;GO:0001542,biological_process ovulation from ovarian follicle;GO:0001554,biological_process luteolysis;GO:0004222,molecular_function metalloendopeptidase activity;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0007275,biological_process multicellular organism development;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0009725,biological_process response to hormone;GO:0016787,molecular_function hydrolase activity;GO:0022617,biological_process extracellular matrix disassembly;GO:0030154,biological_process cell differentiation;GO:0030574,biological_process collagen catabolic process;GO:0031012,cellular_component extracellular matrix;GO:0046872,molecular_function metal ion binding;GO:0051591,biological_process response to cAMP	NA	matrix metallopeptidase 19 [Source:HGNC Symbol%3BAcc:HGNC:7165]
ENSG00000157107	5.78	6.13	6.50	5.74	6.30	6.53	-0.00143029923704457	4.04369908616108	1	1	5:72955980-73090522:+	FCHO2	17;GO:0001786,molecular_function phosphatidylserine binding;GO:0005515,molecular_function protein binding;GO:0005546,molecular_function phosphatidylinositol-4,5-bisphosphate binding;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005905,cellular_component clathrin-coated pit;GO:0006897,biological_process endocytosis;GO:0010324,biological_process membrane invagination;GO:0016020,cellular_component membrane;GO:0030136,cellular_component clathrin-coated vesicle;GO:0035091,molecular_function phosphatidylinositol binding;GO:0048268,biological_process clathrin coat assembly;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0061024,biological_process membrane organization;GO:0072583,biological_process clathrin-mediated endocytosis;GO:0072659,biological_process protein localization to plasma membrane;GO:0098835,cellular_component presynaptic endocytic zone membrane	NA	FCH domain only 2 [Source:HGNC Symbol%3BAcc:HGNC:25180]
ENSG00000065923	6.56	6.25	7.67	7.09	6.17	7.46	-0.00141259322081811	3.92760157087769	1	1	X:46599251-46759172:-	SLC9A7	27;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005768,cellular_component endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005802,cellular_component trans-Golgi network;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006813,biological_process potassium ion transport;GO:0006814,biological_process sodium ion transport;GO:0006885,biological_process regulation of pH;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015386,molecular_function potassium:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035725,biological_process sodium ion transmembrane transport;GO:0042803,molecular_function protein homodimerization activity;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0051453,biological_process regulation of intracellular pH;GO:0055038,cellular_component recycling endosome membrane;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:0098719,biological_process sodium ion import across plasma membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	solute carrier family 9 member A7 [Source:HGNC Symbol%3BAcc:HGNC:17123]
ENSG00000047621	7.37	7.98	9.31	7.64	8.33	8.89	0.000268966630250081	3.80787742495503	1	1	12:4487727-4538508:-	C12orf4	2;GO:0005737,cellular_component cytoplasm;GO:0043304,biological_process regulation of mast cell degranulation	NA	chromosome 12 open reading frame 4 [Source:HGNC Symbol%3BAcc:HGNC:1184]
ENSG00000172139	0.56	0.27	0.58	0.74	0.32	0.34	0.0557219663782298	0.876028648600879	1	1	3:112140886-112294258:-	SLC9C1	24;GO:0005216,molecular_function ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0005929,cellular_component cilium;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006814,biological_process sodium ion transport;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0015297,molecular_function antiporter activity;GO:0015299,molecular_function solute:proton antiporter activity;GO:0015385,molecular_function sodium:proton antiporter activity;GO:0015386,molecular_function potassium:proton antiporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030154,biological_process cell differentiation;GO:0030317,biological_process sperm motility;GO:0031514,cellular_component motile cilium;GO:0042995,cellular_component cell projection;GO:0051453,biological_process regulation of intracellular pH;GO:0055085,biological_process transmembrane transport;GO:0071805,biological_process potassium ion transmembrane transport;GO:0098719,biological_process sodium ion import across plasma membrane;GO:1902600,biological_process hydrogen ion transmembrane transport	NA	solute carrier family 9 member C1 [Source:HGNC Symbol%3BAcc:HGNC:31401]
ENSG00000174871	2.47	3.87	3.52	3.59	2.10	4.27	-0.0271335244948498	0.954947582710789	1	1	11:66278189-66285301:+	CNIH2	28;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006888,biological_process ER to Golgi vesicle-mediated transport;GO:0012507,cellular_component ER to Golgi transport vesicle membrane;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030425,cellular_component dendrite;GO:0032281,cellular_component AMPA glutamate receptor complex;GO:0033116,cellular_component endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0035249,biological_process synaptic transmission, glutamatergic;GO:0042391,biological_process regulation of membrane potential;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043198,cellular_component dendritic shaft;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048208,biological_process COPII vesicle coating;GO:0051668,biological_process localization within membrane;GO:1902684,biological_process negative regulation of receptor localization to synapse;GO:1903743,biological_process negative regulation of anterograde synaptic vesicle transport;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	NA	cornichon family AMPA receptor auxiliary protein 2 [Source:HGNC Symbol%3BAcc:HGNC:28744]
ENSG00000134852	7.62	9.30	7.54	8.85	7.86	7.92	-0.00713238818069674	4.38249021868009	1	1	4:55427902-55547138:-	CLOCK	47;GO:0000077,biological_process DNA damage checkpoint;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000982,molecular_function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001046,molecular_function core promoter sequence-specific DNA binding;GO:0001047,molecular_function core promoter binding;GO:0001190,molecular_function transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0004402,molecular_function histone acetyltransferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005667,cellular_component transcription factor complex;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007165,biological_process signal transduction;GO:0007283,biological_process spermatogenesis;GO:0007623,biological_process circadian rhythm;GO:0009648,biological_process photoperiodism;GO:0016573,biological_process histone acetylation;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0031490,molecular_function chromatin DNA binding;GO:0032922,biological_process circadian regulation of gene expression;GO:0033391,cellular_component chromatoid body;GO:0042634,biological_process regulation of hair cycle;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity;GO:0048511,biological_process rhythmic process;GO:0050729,biological_process positive regulation of inflammatory response;GO:0050796,biological_process regulation of insulin secretion;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051775,biological_process response to redox state;GO:0070888,molecular_function E-box binding;GO:0071479,biological_process cellular response to ionizing radiation;GO:2000074,biological_process regulation of type B pancreatic cell development;GO:2000323,biological_process negative regulation of glucocorticoid receptor signaling pathway	CLOCK, KAT13D; circadian locomoter output cycles kaput protein [EC:2.3.1.48]; K02223	clock circadian regulator [Source:HGNC Symbol%3BAcc:HGNC:2082]
ENSG00000153208	3.24	2.77	2.87	3.35	2.81	2.80	0.00598014934878502	3.39848399802364	1	1	2:111898478-112029561:+	MERTK	37;GO:0000166,molecular_function nucleotide binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0001779,biological_process natural killer cell differentiation;GO:0001818,biological_process negative regulation of cytokine production;GO:0004672,molecular_function protein kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0004714,molecular_function transmembrane receptor protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006909,biological_process phagocytosis;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007267,biological_process cell-cell signaling;GO:0007283,biological_process spermatogenesis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016028,cellular_component rhabdomere;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0030168,biological_process platelet activation;GO:0032940,biological_process secretion by cell;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0043277,biological_process apoptotic cell clearance;GO:0043491,biological_process protein kinase B signaling;GO:0050766,biological_process positive regulation of phagocytosis;GO:0050900,biological_process leukocyte migration;GO:0051250,biological_process negative regulation of lymphocyte activation;GO:0060041,biological_process retina development in camera-type eye;GO:0060068,biological_process vagina development;GO:0097350,biological_process neutrophil clearance;GO:2000107,biological_process negative regulation of leukocyte apoptotic process	NA	MER proto-oncogene%2C tyrosine kinase [Source:HGNC Symbol%3BAcc:HGNC:7027]
ENSG00000277363	0.20	0.25	0.15	0.16	0.25	0.22	-0.0883949584956565	0.107019946533999	1	1	17:38530015-38605930:-	SRCIN1	26;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0006887,biological_process exocytosis;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0019901,molecular_function protein kinase binding;GO:0019904,molecular_function protein domain specific binding;GO:0030027,cellular_component lamellipodium;GO:0030054,cellular_component cell junction;GO:0030175,cellular_component filopodium;GO:0030334,biological_process regulation of cell migration;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0034446,biological_process substrate adhesion-dependent cell spreading;GO:0042995,cellular_component cell projection;GO:0043005,cellular_component neuron projection;GO:0043025,cellular_component neuronal cell body;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0050709,biological_process negative regulation of protein secretion;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0061098,biological_process positive regulation of protein tyrosine kinase activity;GO:0061099,biological_process negative regulation of protein tyrosine kinase activity	NA	SRC kinase signaling inhibitor 1 [Source:HGNC Symbol%3BAcc:HGNC:29506]
ENSG00000165272	1.53	0.33	0.84	0.77	0.69	1.20	0.0863409599537825	-0.056254875369471	1	1	9:33441153-33447611:-	AQP3	25;GO:0002684,biological_process positive regulation of immune system process;GO:0003091,biological_process renal water homeostasis;GO:0005215,molecular_function transporter activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0006810,biological_process transport;GO:0006833,biological_process water transport;GO:0007588,biological_process excretion;GO:0015250,molecular_function water channel activity;GO:0015254,molecular_function glycerol channel activity;GO:0015793,biological_process glycerol transport;GO:0015840,biological_process urea transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0032526,biological_process response to retinoic acid;GO:0033280,biological_process response to vitamin D;GO:0042476,biological_process odontogenesis;GO:0045616,biological_process regulation of keratinocyte differentiation;GO:0051592,biological_process response to calcium ion;GO:0070295,biological_process renal water absorption;GO:0071456,biological_process cellular response to hypoxia;GO:0090650,biological_process cellular response to oxygen-glucose deprivation	AQP3; aquaporin-3; K09876	aquaporin 3 (Gill blood group) [Source:HGNC Symbol%3BAcc:HGNC:636]
ENSG00000159905	0.88	0.67	0.87	0.81	0.82	0.76	0.0528568283925824	0.719166736168588	1	1	19:43951222-43967709:+	ZNF221	4;GO:0003676,molecular_function nucleic acid binding;GO:0005622,cellular_component intracellular;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 221 [Source:HGNC Symbol%3BAcc:HGNC:13014]
ENSG00000275183	1.38	0.80	0.82	0.99	0.95	1.03	0.0485249900629902	0.673711684332446	1	1	19:54461795-54463711:-	LENG9	1;GO:0046872,molecular_function metal ion binding	NA	leukocyte receptor cluster member 9 [Source:HGNC Symbol%3BAcc:HGNC:16306]
ENSG00000182752	0.26	0.23	0.36	0.26	0.37	0.22	0.0466750953811288	0.627889707641102	1	1	9:116153803-116402322:+	PAPPA	14;GO:0004175,molecular_function endopeptidase activity;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0007565,biological_process female pregnancy;GO:0008233,molecular_function peptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0016787,molecular_function hydrolase activity;GO:0032354,biological_process response to follicle-stimulating hormone;GO:0044267,biological_process cellular protein metabolic process;GO:0046872,molecular_function metal ion binding;GO:0051384,biological_process response to glucocorticoid	NA	pappalysin 1 [Source:HGNC Symbol%3BAcc:HGNC:8602]
ENSG00000274070	1.43	1.26	1.12	1.21	1.46	1.07	0.0442612090374196	0.4786789357401	1	1	7:74964817-75024798:+	CASTOR2	6;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0042802,molecular_function identical protein binding;GO:0061700,cellular_component GATOR2 complex;GO:1904262,biological_process negative regulation of TORC1 signaling	NA	cytosolic arginine sensor for mTORC1 subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:37073]
ENSG00000147437	6.40	4.16	3.47	5.97	4.67	3.31	0.0405660405433391	0.529929485198575	1	1	8:25419259-25424654:-	GNRH1	36;GO:0005179,molecular_function hormone activity;GO:0005183,molecular_function gonadotropin hormone-releasing hormone activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005739,cellular_component mitochondrion;GO:0005798,cellular_component Golgi-associated vesicle;GO:0007165,biological_process signal transduction;GO:0007267,biological_process cell-cell signaling;GO:0007275,biological_process multicellular organism development;GO:0007565,biological_process female pregnancy;GO:0007568,biological_process aging;GO:0008285,biological_process negative regulation of cell proliferation;GO:0010468,biological_process regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0030238,biological_process male sex determination;GO:0030425,cellular_component dendrite;GO:0031960,biological_process response to corticosteroid;GO:0032496,biological_process response to lipopolysaccharide;GO:0033087,biological_process negative regulation of immature T cell proliferation;GO:0033574,biological_process response to testosterone;GO:0034695,biological_process response to prostaglandin E;GO:0035864,biological_process response to potassium ion;GO:0042698,biological_process ovulation cycle;GO:0043005,cellular_component neuron projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043204,cellular_component perikaryon;GO:0043434,biological_process response to peptide hormone;GO:0043679,cellular_component axon terminus;GO:0044849,biological_process estrous cycle;GO:0045471,biological_process response to ethanol;GO:0048545,biological_process response to steroid hormone;GO:0098556,cellular_component cytoplasmic side of rough endoplasmic reticulum membrane;GO:1990008,cellular_component neurosecretory vesicle;GO:1990637,biological_process response to prolactin;GO:2000354,biological_process regulation of ovarian follicle development;GO:2001223,biological_process negative regulation of neuron migration	GNRH; gonadotropin-releasing hormone; K05252	gonadotropin releasing hormone 1 [Source:HGNC Symbol%3BAcc:HGNC:4419]
ENSG00000125775	2.58	1.42	2.44	2.31	1.73	2.41	0.0391884893428471	1.04446006996574	1	1	20:1309908-1329239:-	SDCBP2	11;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0007399,biological_process nervous system development;GO:0008022,molecular_function protein C-terminus binding;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0046907,biological_process intracellular transport;GO:0046982,molecular_function protein heterodimerization activity;GO:0070062,cellular_component extracellular exosome	NA	syndecan binding protein 2 [Source:HGNC Symbol%3BAcc:HGNC:15756]
ENSG00000133808	0.54	0.41	0.67	0.57	0.44	0.61	0.0376267988966162	0.369045587118579	1	1	11:12276079-12359144:+	MICALCL	6;GO:0005737,cellular_component cytoplasm;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0008150,biological_process biological_process;GO:0030154,biological_process cell differentiation;GO:0051019,molecular_function mitogen-activated protein kinase binding	NA	MICAL C-terminal like [Source:HGNC Symbol%3BAcc:HGNC:25933]
ENSG00000158715	1.66	1.04	1.60	1.67	0.87	1.74	0.0347296949076666	1.3536895354154	1	1	1:205657850-205680459:-	SLC45A3	13;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0008506,molecular_function sucrose:proton symporter activity;GO:0008645,biological_process hexose transport;GO:0010907,biological_process positive regulation of glucose metabolic process;GO:0015770,biological_process sucrose transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034219,biological_process carbohydrate transmembrane transport;GO:0045723,biological_process positive regulation of fatty acid biosynthetic process;GO:0048713,biological_process regulation of oligodendrocyte differentiation;GO:0051119,molecular_function sugar transmembrane transporter activity;GO:0055085,biological_process transmembrane transport	SLC45A3; solute carrier family 45, member 3; K15379	solute carrier family 45 member 3 [Source:HGNC Symbol%3BAcc:HGNC:8642]
ENSG00000115423	0.13	0.11	0.14	0.12	0.16	0.10	0.0315975232080637	0.795325907055446	1	1	2:84516454-84819589:+	DNAH6	19;GO:0000166,molecular_function nucleotide binding;GO:0001539,biological_process cilium or flagellum-dependent cell motility;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005858,cellular_component axonemal dynein complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0016887,molecular_function ATPase activity;GO:0030286,cellular_component dynein complex;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060271,biological_process cilium morphogenesis	NA	dynein axonemal heavy chain 6 [Source:HGNC Symbol%3BAcc:HGNC:2951]
ENSG00000074047	0.65	0.44	0.65	0.69	0.54	0.52	0.0313546375058358	1.56033861270931	1	1	2:120735622-120992653:+	GLI2	91;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001501,biological_process skeletal system development;GO:0001649,biological_process osteoblast differentiation;GO:0001701,biological_process in utero embryonic development;GO:0001822,biological_process kidney development;GO:0002009,biological_process morphogenesis of an epithelium;GO:0002062,biological_process chondrocyte differentiation;GO:0002076,biological_process osteoblast development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005929,cellular_component cilium;GO:0005930,cellular_component axoneme;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007224,biological_process smoothened signaling pathway;GO:0007275,biological_process multicellular organism development;GO:0007389,biological_process pattern specification process;GO:0007411,biological_process axon guidance;GO:0007418,biological_process ventral midline development;GO:0007442,biological_process hindgut morphogenesis;GO:0007507,biological_process heart development;GO:0008134,molecular_function transcription factor binding;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0008284,biological_process positive regulation of cell proliferation;GO:0008589,biological_process regulation of smoothened signaling pathway;GO:0009612,biological_process response to mechanical stimulus;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0009954,biological_process proximal/distal pattern formation;GO:0016020,cellular_component membrane;GO:0016607,cellular_component nuclear speck;GO:0021508,biological_process floor plate formation;GO:0021513,biological_process spinal cord dorsal/ventral patterning;GO:0021517,biological_process ventral spinal cord development;GO:0021522,biological_process spinal cord motor neuron differentiation;GO:0021696,biological_process cerebellar cortex morphogenesis;GO:0021775,biological_process smoothened signaling pathway involved in ventral spinal cord interneuron specification;GO:0021776,biological_process smoothened signaling pathway involved in spinal cord motor neuron cell fate specification;GO:0021904,biological_process dorsal/ventral neural tube patterning;GO:0021915,biological_process neural tube development;GO:0021938,biological_process smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation;GO:0021965,biological_process spinal cord ventral commissure morphogenesis;GO:0021983,biological_process pituitary gland development;GO:0030154,biological_process cell differentiation;GO:0030324,biological_process lung development;GO:0030850,biological_process prostate gland development;GO:0030879,biological_process mammary gland development;GO:0030902,biological_process hindbrain development;GO:0031514,cellular_component motile cilium;GO:0032331,biological_process negative regulation of chondrocyte differentiation;GO:0033089,biological_process positive regulation of T cell differentiation in thymus;GO:0035295,biological_process tube development;GO:0042475,biological_process odontogenesis of dentin-containing tooth;GO:0042733,biological_process embryonic digit morphogenesis;GO:0042995,cellular_component cell projection;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044212,molecular_function transcription regulatory region DNA binding;GO:0045666,biological_process positive regulation of neuron differentiation;GO:0045740,biological_process positive regulation of DNA replication;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048566,biological_process embryonic digestive tract development;GO:0048589,biological_process developmental growth;GO:0048646,biological_process anatomical structure formation involved in morphogenesis;GO:0048666,biological_process neuron development;GO:0048754,biological_process branching morphogenesis of an epithelial tube;GO:0048856,biological_process anatomical structure development;GO:0060032,biological_process notochord regression;GO:0060322,biological_process head development;GO:0060513,biological_process prostatic bud formation;GO:0060603,biological_process mammary gland duct morphogenesis;GO:0060831,biological_process smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0071407,biological_process cellular response to organic cyclic compound;GO:0090103,biological_process cochlea morphogenesis;GO:0097542,cellular_component ciliary tip;GO:0097546,cellular_component ciliary base;GO:1990841,molecular_function promoter-specific chromatin binding	GLI2; zinc finger protein GLI2; K16798	GLI family zinc finger 2 [Source:HGNC Symbol%3BAcc:HGNC:4318]
ENSG00000183628	1.35	1.32	2.11	1.51	1.45	1.80	0.0303641269263499	0.730156488304796	1	1	22:18906027-18914238:+	DGCR6	5;GO:0003674,molecular_function molecular_function;GO:0005578,cellular_component proteinaceous extracellular matrix;GO:0005634,cellular_component nucleus;GO:0007155,biological_process cell adhesion;GO:0009887,biological_process organ morphogenesis	NA	DiGeorge syndrome critical region gene 6 [Source:HGNC Symbol%3BAcc:HGNC:2846]
ENSG00000197046	2.58	1.56	2.55	2.88	2.04	1.83	0.0296460824198627	1.32550390491572	1	1	18:45825511-45844080:+	SIGLEC15	9;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032956,biological_process regulation of actin cytoskeleton organization;GO:0043234,cellular_component protein complex;GO:0045087,biological_process innate immune response;GO:0045124,biological_process regulation of bone resorption;GO:0071402,biological_process cellular response to lipoprotein particle stimulus;GO:2001204,biological_process regulation of osteoclast development	NA	sialic acid binding Ig like lectin 15 [Source:HGNC Symbol%3BAcc:HGNC:27596]
ENSG00000187642	0.59	0.12	0.46	0.37	0.54	0.35	-0.0296410640419895	0.203706199600333	1	1	1:975203-982093:-	PERM1	5;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0014850,biological_process response to muscle activity	NA	PPARGC1 and ESRR induced regulator%2C muscle 1 [Source:HGNC Symbol%3BAcc:HGNC:28208]
ENSG00000170049	1.03	0.73	1.35	1.09	0.87	1.29	-0.0290561878167107	0.638757413162926	1	1	17:7921858-7929803:-	KCNAB3	12;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0015459,molecular_function potassium channel regulator activity;GO:0016021,cellular_component integral component of membrane;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0065009,biological_process regulation of molecular function;GO:0071805,biological_process potassium ion transmembrane transport	NA	potassium voltage-gated channel subfamily A regulatory beta subunit 3 [Source:HGNC Symbol%3BAcc:HGNC:6230]
ENSG00000212643	1.38	1.40	1.08	1.46	0.90	1.57	-0.0287992017801614	1.01000283812374	1	1	5:112891421-112893094:+	ZRSR1	10;GO:0000398,biological_process mRNA splicing, via spliceosome;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005681,cellular_component spliceosomal complex;GO:0008150,biological_process biological_process;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030628,molecular_function pre-mRNA 3'-splice site binding;GO:0046872,molecular_function metal ion binding;GO:0089701,cellular_component U2AF	NA	zinc finger CCCH-type%2C RNA binding motif and serine/arginine rich 1 [Source:HGNC Symbol%3BAcc:HGNC:12456]
ENSG00000188107	0.18	0.27	0.21	0.19	0.27	0.20	-0.0287972235526188	1.17415877602808	1	1	6:63719979-65707225:-	EYS	8;GO:0003674,molecular_function molecular_function;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0007601,biological_process visual perception;GO:0043403,biological_process skeletal muscle tissue regeneration;GO:0050896,biological_process response to stimulus;GO:0050908,biological_process detection of light stimulus involved in visual perception;GO:0070062,cellular_component extracellular exosome	NA	eyes shut homolog (Drosophila) [Source:HGNC Symbol%3BAcc:HGNC:21555]
ENSG00000123977	0.94	0.47	0.41	0.78	0.74	0.39	-0.028740441003628	0.0719265657803749	1	1	2:227871053-227924344:+	DAW1	5;GO:0005737,cellular_component cytoplasm;GO:0005929,cellular_component cilium;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0042995,cellular_component cell projection	NA	dynein assembly factor with WD repeats 1 [Source:HGNC Symbol%3BAcc:HGNC:26383]
ENSG00000213901	0.76	0.26	0.75	0.57	0.61	0.64	0.026886193450724	0.368306633219853	1	1	2:219161464-219170095:-	SLC23A3	5;GO:0005215,molecular_function transporter activity;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0055085,biological_process transmembrane transport	NA	solute carrier family 23 member 3 [Source:HGNC Symbol%3BAcc:HGNC:20601]
ENSG00000154146	4.53	4.90	2.52	3.20	5.19	3.31	0.0267670074298669	0.090043421744793	1	1	11:124739845-124747210:+	NRGN	20;GO:0005516,molecular_function calmodulin binding;GO:0005547,molecular_function phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0007165,biological_process signal transduction;GO:0007399,biological_process nervous system development;GO:0008306,biological_process associative learning;GO:0012510,cellular_component trans-Golgi network transport vesicle membrane;GO:0014069,cellular_component postsynaptic density;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0021537,biological_process telencephalon development;GO:0030424,cellular_component axon;GO:0030425,cellular_component dendrite;GO:0031966,cellular_component mitochondrial membrane;GO:0043025,cellular_component neuronal cell body;GO:0044327,cellular_component dendritic spine head;GO:0045202,cellular_component synapse;GO:0070300,molecular_function phosphatidic acid binding;GO:1900273,biological_process positive regulation of long-term synaptic potentiation	NA	neurogranin [Source:HGNC Symbol%3BAcc:HGNC:8000]
ENSG00000162188	8.16	6.37	8.18	8.32	9.44	5.94	-0.0258064468361049	0.925822949638237	1	1	11:62707657-62709201:+	GNG3	16;GO:0000187,biological_process activation of MAPK activity;GO:0001664,molecular_function G-protein coupled receptor binding;GO:0003924,molecular_function GTPase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005834,cellular_component heterotrimeric G-protein complex;GO:0005886,cellular_component plasma membrane;GO:0007165,biological_process signal transduction;GO:0007186,biological_process G-protein coupled receptor signaling pathway;GO:0007204,biological_process positive regulation of cytosolic calcium ion concentration;GO:0014069,cellular_component postsynaptic density;GO:0016020,cellular_component membrane;GO:0030425,cellular_component dendrite;GO:0031702,molecular_function type 1 angiotensin receptor binding;GO:0044297,cellular_component cell body;GO:0071377,biological_process cellular response to glucagon stimulus	NA	G protein subunit gamma 3 [Source:HGNC Symbol%3BAcc:HGNC:4405]
ENSG00000157423	0.04	0.05	0.08	0.06	0.08	0.04	0.025648186251658	0.156833847663872	1	1	16:70807377-71230722:-	HYDIN	9;GO:0002064,biological_process epithelial cell development;GO:0003341,biological_process cilium movement;GO:0005929,cellular_component cilium;GO:0007275,biological_process multicellular organism development;GO:0021591,biological_process ventricular system development;GO:0042995,cellular_component cell projection;GO:0060438,biological_process trachea development;GO:1904158,biological_process axonemal central apparatus assembly;GO:1990718,cellular_component axonemal central pair projection	NA	HYDIN%2C axonemal central pair apparatus protein [Source:HGNC Symbol%3BAcc:HGNC:19368]
ENSG00000167861	1.01	0.64	0.73	0.83	0.93	0.64	0.0246576294219409	1.12291113786031	1	1	17:74950742-74973166:-	HID1	13;GO:0000138,cellular_component Golgi trans cisterna;GO:0000139,cellular_component Golgi membrane;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0005797,cellular_component Golgi medial cisterna;GO:0005829,cellular_component cytosol;GO:0005881,cellular_component cytoplasmic microtubule;GO:0006886,biological_process intracellular protein transport;GO:0016020,cellular_component membrane;GO:0031001,biological_process response to brefeldin A;GO:0070062,cellular_component extracellular exosome;GO:0090498,cellular_component extrinsic component of Golgi membrane	NA	HID1 domain containing [Source:HGNC Symbol%3BAcc:HGNC:15736]
ENSG00000099625	0.78	0.86	1.09	0.80	0.93	1.07	-0.0241151490637917	1.26676790223035	1	1	19:1228286-1238027:-	CBARP	14;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030141,cellular_component secretory granule;GO:0030426,cellular_component growth cone;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042995,cellular_component cell projection;GO:0044325,molecular_function ion channel binding;GO:0045202,cellular_component synapse;GO:0045955,biological_process negative regulation of calcium ion-dependent exocytosis;GO:1901386,biological_process negative regulation of voltage-gated calcium channel activity;GO:1903170,biological_process negative regulation of calcium ion transmembrane transport	NA	CACN beta subunit associated regulatory protein [Source:HGNC Symbol%3BAcc:HGNC:28617]
ENSG00000056558	3.06	1.99	3.54	3.12	2.31	3.21	0.0229260517182216	1.91896098696942	1	1	9:120902392-120929173:-	TRAF1	15;GO:0005164,molecular_function tumor necrosis factor receptor binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006461,biological_process protein complex assembly;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0010803,biological_process regulation of tumor necrosis factor-mediated signaling pathway;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031996,molecular_function thioesterase binding;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:2001236,biological_process regulation of extrinsic apoptotic signaling pathway	TRAF1; TNF receptor-associated factor 1; K03172	TNF receptor associated factor 1 [Source:HGNC Symbol%3BAcc:HGNC:12031]
ENSG00000162065	2.48	3.42	1.80	2.23	3.08	2.47	-0.0226809322980862	2.14698877748275	1	1	16:2475050-2509560:+	TBC1D24	9;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0030054,cellular_component cell junction;GO:0031175,biological_process neuron projection development;GO:0031594,cellular_component neuromuscular junction;GO:0043195,cellular_component terminal bouton;GO:0043547,biological_process positive regulation of GTPase activity	NA	TBC1 domain family member 24 [Source:HGNC Symbol%3BAcc:HGNC:29203]
ENSG00000111261	0.82	0.89	0.46	0.87	1.06	0.22	0.0223536641570092	0.0904331677610073	1	1	12:12326055-12350541:-	MANSC1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	MANSC domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:25505]
ENSG00000166578	2.18	2.60	1.86	2.36	1.92	2.43	-0.0222413221081616	1.90263080297474	1	1	12:113195440-113221094:-	IQCD	NA	NA	IQ motif containing D [Source:HGNC Symbol%3BAcc:HGNC:25168]
ENSG00000165997	11.05	8.01	9.59	10.18	9.18	9.43	0.0219220697148831	2.41332304545096	1	1	10:18659404-18681639:+	ARL5B	4;GO:0000166,molecular_function nucleotide binding;GO:0005525,molecular_function GTP binding;GO:0005622,cellular_component intracellular;GO:0007264,biological_process small GTPase mediated signal transduction	NA	ADP ribosylation factor like GTPase 5B [Source:HGNC Symbol%3BAcc:HGNC:23052]
ENSG00000205609	1.26	1.57	1.15	1.34	1.33	1.36	-0.0218642007560918	1.92241085260972	1	1	16:28379578-28403879:-	EIF3CL	7;GO:0003723,molecular_function RNA binding;GO:0003743,molecular_function translation initiation factor activity;GO:0005737,cellular_component cytoplasm;GO:0005852,cellular_component eukaryotic translation initiation factor 3 complex;GO:0006412,biological_process translation;GO:0006413,biological_process translational initiation;GO:0031369,molecular_function translation initiation factor binding	EIF3C; translation initiation factor 3 subunit C; K03252	eukaryotic translation initiation factor 3 subunit C like [Source:HGNC Symbol%3BAcc:HGNC:26347]
ENSG00000120278	0.47	0.44	0.65	0.36	0.45	0.74	0.0216915908202636	1.22740174782037	1	1	6:150599882-150843665:+	PLEKHG1	6;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	pleckstrin homology and RhoGEF domain containing G1 [Source:HGNC Symbol%3BAcc:HGNC:20884]
ENSG00000233198	1.06	2.04	2.36	2.88	1.13	1.35	0.0213791960738304	-0.0168641860241706	1	1	9:137227270-137229638:+	RNF224	1;GO:0046872,molecular_function metal ion binding	NA	ring finger protein 224 [Source:HGNC Symbol%3BAcc:HGNC:41912]
ENSG00000164124	1.89	2.73	1.65	1.62	2.36	2.31	-0.0213412897275634	1.34955919009213	1	1	4:158201603-158255411:+	TMEM144	4;GO:0015144,molecular_function carbohydrate transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0034219,biological_process carbohydrate transmembrane transport	NA	transmembrane protein 144 [Source:HGNC Symbol%3BAcc:HGNC:25633]
ENSG00000273045	2.07	4.33	2.16	2.00	3.84	2.63	-0.0212458229212701	0.25309293745501	1	1	2:99141484-99151487:+	C2orf15	1;GO:0003723,molecular_function RNA binding	NA	chromosome 2 open reading frame 15 [Source:HGNC Symbol%3BAcc:HGNC:28436]
ENSG00000133069	0.62	0.68	0.83	0.85	0.48	0.85	-0.0207774527922767	0.906353187634321	1	1	1:205228175-205273343:+	TMCC2	5;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042982,biological_process amyloid precursor protein metabolic process	NA	transmembrane and coiled-coil domain family 2 [Source:HGNC Symbol%3BAcc:HGNC:24239]
ENSG00000143858	0.96	0.46	0.82	0.89	0.30	1.06	0.0207742279035022	0.155508278043845	1	1	1:202590595-202710417:-	SYT2	25;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005544,molecular_function calcium-dependent phospholipid binding;GO:0005886,cellular_component plasma membrane;GO:0006906,biological_process vesicle fusion;GO:0007269,biological_process neurotransmitter secretion;GO:0008021,cellular_component synaptic vesicle;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017158,biological_process regulation of calcium ion-dependent exocytosis;GO:0019905,molecular_function syntaxin binding;GO:0030054,cellular_component cell junction;GO:0030154,biological_process cell differentiation;GO:0030276,molecular_function clathrin binding;GO:0030665,cellular_component clathrin-coated vesicle membrane;GO:0030672,cellular_component synaptic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0042584,cellular_component chromaffin granule membrane;GO:0043533,molecular_function inositol 1,3,4,5 tetrakisphosphate binding;GO:0045202,cellular_component synapse;GO:0046872,molecular_function metal ion binding;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0048791,biological_process calcium ion-regulated exocytosis of neurotransmitter;GO:0061024,biological_process membrane organization;GO:1903861,biological_process positive regulation of dendrite extension	NA	synaptotagmin 2 [Source:HGNC Symbol%3BAcc:HGNC:11510]
ENSG00000131979	3.29	2.97	2.91	3.31	2.63	3.20	0.0187142413171133	1.43839739027449	1	1	14:54842007-54902852:-	GCH1	47;GO:0000166,molecular_function nucleotide binding;GO:0003824,molecular_function catalytic activity;GO:0003924,molecular_function GTPase activity;GO:0003934,molecular_function GTP cyclohydrolase I activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006461,biological_process protein complex assembly;GO:0006729,biological_process tetrahydrobiopterin biosynthetic process;GO:0006809,biological_process nitric oxide biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008217,biological_process regulation of blood pressure;GO:0008270,molecular_function zinc ion binding;GO:0010460,biological_process positive regulation of heart rate;GO:0014916,biological_process regulation of lung blood pressure;GO:0016787,molecular_function hydrolase activity;GO:0030742,molecular_function GTP-dependent protein binding;GO:0031369,molecular_function translation initiation factor binding;GO:0031410,cellular_component cytoplasmic vesicle;GO:0031965,cellular_component nuclear membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0034341,biological_process response to interferon-gamma;GO:0034612,biological_process response to tumor necrosis factor;GO:0035998,biological_process 7,8-dihydroneopterin 3'-triphosphate biosynthetic process;GO:0042311,biological_process vasodilation;GO:0042416,biological_process dopamine biosynthetic process;GO:0042559,biological_process pteridine-containing compound biosynthetic process;GO:0042803,molecular_function protein homodimerization activity;GO:0043234,cellular_component protein complex;GO:0044306,cellular_component neuron projection terminus;GO:0045776,biological_process negative regulation of blood pressure;GO:0046654,biological_process tetrahydrofolate biosynthetic process;GO:0046872,molecular_function metal ion binding;GO:0048265,biological_process response to pain;GO:0050662,molecular_function coenzyme binding;GO:0050884,biological_process neuromuscular process controlling posture;GO:0050999,biological_process regulation of nitric-oxide synthase activity;GO:0051000,biological_process positive regulation of nitric-oxide synthase activity;GO:0051019,molecular_function mitogen-activated protein kinase binding;GO:0051066,biological_process dihydrobiopterin metabolic process;GO:0051260,biological_process protein homooligomerization;GO:0051291,biological_process protein heterooligomerization;GO:2000121,biological_process regulation of removal of superoxide radicals	GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]; K01495	GTP cyclohydrolase 1 [Source:HGNC Symbol%3BAcc:HGNC:4193]
ENSG00000175984	0.63	0.65	0.50	0.56	0.52	0.68	0.0181279823924396	0.847031082234647	1	1	1:114582847-114670422:-	DENND2C	3;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0017112,molecular_function Rab guanyl-nucleotide exchange factor activity;GO:0043547,biological_process positive regulation of GTPase activity	NA	DENN domain containing 2C [Source:HGNC Symbol%3BAcc:HGNC:24748]
ENSG00000173894	1.27	1.72	1.48	1.39	1.60	1.52	-0.0181212165833833	1.60510148579731	1	1	17:79778131-79787983:+	CBX2	17;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000791,cellular_component euchromatin;GO:0000792,cellular_component heterochromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007548,biological_process sex differentiation;GO:0016569,biological_process covalent chromatin modification;GO:0030154,biological_process cell differentiation;GO:0031519,cellular_component PcG protein complex;GO:0035064,molecular_function methylated histone binding;GO:0035102,cellular_component PRC1 complex;GO:0045137,biological_process development of primary sexual characteristics	NA	chromobox 2 [Source:HGNC Symbol%3BAcc:HGNC:1552]
ENSG00000189143	2.82	1.98	1.29	1.67	2.06	2.36	0.0175833210009988	0.516981760134356	1	1	7:73799541-73832693:+	CLDN4	19;GO:0004888,molecular_function transmembrane signaling receptor activity;GO:0005198,molecular_function structural molecule activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005923,cellular_component bicellular tight junction;GO:0007165,biological_process signal transduction;GO:0007565,biological_process female pregnancy;GO:0007623,biological_process circadian rhythm;GO:0009925,cellular_component basal plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016324,cellular_component apical plasma membrane;GO:0016327,cellular_component apicolateral plasma membrane;GO:0016328,cellular_component lateral plasma membrane;GO:0016338,biological_process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030054,cellular_component cell junction;GO:0032570,biological_process response to progesterone;GO:0042802,molecular_function identical protein binding;GO:0061436,biological_process establishment of skin barrier	CLDN; claudin; K06087	claudin 4 [Source:HGNC Symbol%3BAcc:HGNC:2046]
ENSG00000233954	6.98	2.80	8.36	7.95	3.89	6.70	0.0167079376844626	0.895009214883887	1	1	1:15807168-15809348:-	UQCRHL	10;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005750,cellular_component mitochondrial respiratory chain complex III;GO:0006122,biological_process mitochondrial electron transport, ubiquinol to cytochrome c;GO:0008121,molecular_function ubiquinol-cytochrome-c reductase activity;GO:0009060,biological_process aerobic respiration;GO:0016020,cellular_component membrane;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain;GO:1902600,biological_process hydrogen ion transmembrane transport	QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6; K00416	ubiquinol-cytochrome c reductase hinge protein like [Source:HGNC Symbol%3BAcc:HGNC:51714]
ENSG00000165124	0.11	0.12	0.12	0.13	0.08	0.12	0.0165742015807503	0.465380976663569	1	1	9:110365250-110579880:-	SVEP1	7;GO:0003682,molecular_function chromatin binding;GO:0005509,molecular_function calcium ion binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0007155,biological_process cell adhesion;GO:0016020,cellular_component membrane	NA	sushi%2C von Willebrand factor type A%2C EGF and pentraxin domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:15985]
ENSG00000149809	4.77	6.89	5.82	6.03	5.76	5.83	-0.016558379254176	2.95023938740554	1	1	11:65111844-65116384:+	TM7SF2	22;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006694,biological_process steroid biosynthetic process;GO:0006695,biological_process cholesterol biosynthetic process;GO:0008202,biological_process steroid metabolic process;GO:0008203,biological_process cholesterol metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016126,biological_process sterol biosynthetic process;GO:0016491,molecular_function oxidoreductase activity;GO:0016627,molecular_function oxidoreductase activity, acting on the CH-CH group of donors;GO:0016628,molecular_function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0031090,cellular_component organelle membrane;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043235,cellular_component receptor complex;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0050613,molecular_function delta14-sterol reductase activity;GO:0050661,molecular_function NADP binding;GO:0055114,biological_process oxidation-reduction process	TM7SF2, ERG24; Delta14-sterol reductase [EC:1.3.1.70]; K00222	transmembrane 7 superfamily member 2 [Source:HGNC Symbol%3BAcc:HGNC:11863]
ENSG00000010438	0.74	1.09	0.70	0.64	1.37	0.53	-0.0164774556231894	0.0379252333184968	1	1	9:33750465-33799231:+	PRSS3	18;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space;GO:0006508,biological_process proteolysis;GO:0007586,biological_process digestion;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0009235,biological_process cobalamin metabolic process;GO:0016787,molecular_function hydrolase activity;GO:0019730,biological_process antimicrobial humoral response;GO:0031638,biological_process zymogen activation;GO:0043312,biological_process neutrophil degranulation;GO:0043542,biological_process endothelial cell migration;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:1904724,cellular_component tertiary granule lumen	PRSS1_2_3; trypsin [EC:3.4.21.4]; K01312	protease%2C serine 3 [Source:HGNC Symbol%3BAcc:HGNC:9486]
ENSG00000185436	0.67	0.62	0.87	0.62	0.54	1.00	0.0160832529601135	0.464776799436641	1	1	1:24154156-24187959:-	IFNLR1	12;GO:0002385,biological_process mucosal immune response;GO:0004896,molecular_function cytokine receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0019221,biological_process cytokine-mediated signaling pathway;GO:0032002,cellular_component interleukin-28 receptor complex;GO:0034342,biological_process response to type III interferon;GO:0050691,biological_process regulation of defense response to virus by host;GO:0051607,biological_process defense response to virus	IFNLR1, IL28RA; interferon lambda receptor 1; K05140	interferon lambda receptor 1 [Source:HGNC Symbol%3BAcc:HGNC:18584]
ENSG00000235453	7.79	7.66	6.64	9.76	6.65	5.64	0.0157249221621881	1.62266806327449	1	1	9:32551143-32568621:+	SMIM27	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 27 [Source:HGNC Symbol%3BAcc:HGNC:31420]
ENSG00000196338	0.33	0.56	0.49	0.47	0.42	0.50	-0.015575566737224	0.398226220181328	1	1	X:71144830-71171201:+	NLGN3	51;GO:0002087,biological_process regulation of respiratory gaseous exchange by neurological system process;GO:0004872,molecular_function receptor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006898,biological_process receptor-mediated endocytosis;GO:0007155,biological_process cell adhesion;GO:0007158,biological_process neuron cell-cell adhesion;GO:0007416,biological_process synapse assembly;GO:0007612,biological_process learning;GO:0008542,biological_process visual learning;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030139,cellular_component endocytic vesicle;GO:0030534,biological_process adult behavior;GO:0035176,biological_process social behavior;GO:0042043,molecular_function neurexin family protein binding;GO:0045202,cellular_component synapse;GO:0048488,biological_process synaptic vesicle endocytosis;GO:0048675,biological_process axon extension;GO:0048709,biological_process oligodendrocyte differentiation;GO:0050804,biological_process modulation of synaptic transmission;GO:0050808,biological_process synapse organization;GO:0050839,molecular_function cell adhesion molecule binding;GO:0051965,biological_process positive regulation of synapse assembly;GO:0051966,biological_process regulation of synaptic transmission, glutamatergic;GO:0051968,biological_process positive regulation of synaptic transmission, glutamatergic;GO:0052689,molecular_function carboxylic ester hydrolase activity;GO:0060024,biological_process rhythmic synaptic transmission;GO:0060076,cellular_component excitatory synapse;GO:0060079,biological_process excitatory postsynaptic potential;GO:0060080,biological_process inhibitory postsynaptic potential;GO:0060291,biological_process long-term synaptic potentiation;GO:0061001,biological_process regulation of dendritic spine morphogenesis;GO:0061002,biological_process negative regulation of dendritic spine morphogenesis;GO:0071625,biological_process vocalization behavior;GO:0090394,biological_process negative regulation of excitatory postsynaptic potential;GO:0097104,biological_process postsynaptic membrane assembly;GO:0097105,biological_process presynaptic membrane assembly;GO:0097110,molecular_function scaffold protein binding;GO:0098794,cellular_component postsynapse;GO:0099055,cellular_component integral component of postsynaptic membrane;GO:1900271,biological_process regulation of long-term synaptic potentiation;GO:2000310,biological_process regulation of N-methyl-D-aspartate selective glutamate receptor activity;GO:2000311,biological_process regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:2000331,biological_process regulation of terminal button organization;GO:2000463,biological_process positive regulation of excitatory postsynaptic potential;GO:2000809,biological_process positive regulation of synaptic vesicle clustering;GO:2000969,biological_process positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	NLGN; neuroligin; K07378	neuroligin 3 [Source:HGNC Symbol%3BAcc:HGNC:14289]
ENSG00000144668	0.58	0.79	0.47	0.52	0.74	0.53	0.0144132046197009	1.02943169376227	1	1	3:37452114-37823514:+	ITGA9	14;GO:0005518,molecular_function collagen binding;GO:0005886,cellular_component plasma membrane;GO:0007155,biological_process cell adhesion;GO:0007229,biological_process integrin-mediated signaling pathway;GO:0008305,cellular_component integrin complex;GO:0009925,cellular_component basal plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030198,biological_process extracellular matrix organization;GO:0030593,biological_process neutrophil chemotaxis;GO:0034679,cellular_component integrin alpha9-beta1 complex;GO:0042060,biological_process wound healing;GO:0043236,molecular_function laminin binding;GO:0046872,molecular_function metal ion binding	ITGA9; integrin alpha 9; K06585	integrin subunit alpha 9 [Source:HGNC Symbol%3BAcc:HGNC:6145]
ENSG00000121454	2.09	2.59	2.99	2.22	3.01	2.56	-0.0141959890583644	1.67489851220896	1	1	1:180230285-180278982:+	LHX4	16;GO:0001228,molecular_function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001890,biological_process placenta development;GO:0003677,molecular_function DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008045,biological_process motor neuron axon guidance;GO:0009887,biological_process organ morphogenesis;GO:0021526,biological_process medial motor column neuron differentiation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	NA	LIM homeobox 4 [Source:HGNC Symbol%3BAcc:HGNC:21734]
ENSG00000159917	1.04	1.52	1.35	1.37	1.42	1.15	-0.0141623895888522	1.77026103191187	1	1	19:44228728-44305046:-	ZNF235	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 235 [Source:HGNC Symbol%3BAcc:HGNC:12866]
ENSG00000176928	1.09	0.77	0.76	0.39	0.89	1.35	0.013919413899852	0.437838503001286	1	1	5:75025345-75030899:-	GCNT4	18;GO:0000139,cellular_component Golgi membrane;GO:0002121,biological_process inter-male aggressive behavior;GO:0003829,molecular_function beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0006486,biological_process protein glycosylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0008109,molecular_function N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375,molecular_function acetylglucosaminyltransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016266,biological_process O-glycan processing;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0042403,biological_process thyroid hormone metabolic process;GO:0048729,biological_process tissue morphogenesis;GO:0048872,biological_process homeostasis of number of cells;GO:0060993,biological_process kidney morphogenesis	GCNT4; beta-1,6-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-]; K09663	glucosaminyl (N-acetyl) transferase 4%2C core 2 [Source:HGNC Symbol%3BAcc:HGNC:17973]
ENSG00000167100	1.25	0.61	1.67	1.80	0.80	0.99	0.0137076329243705	0.895558467924882	1	1	17:50110039-50129882:-	SAMD14	NA	NA	sterile alpha motif domain containing 14 [Source:HGNC Symbol%3BAcc:HGNC:27312]
ENSG00000064489	0.72	0.65	0.50	0.66	0.46	0.76	-0.0123389499031108	0.106444151285835	1	1	19:19145566-19192158:-	BORCS8-MEF2B	7;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046983,molecular_function protein dimerization activity	MEF2B; MADS-box transcription enhancer factor 2B; K09261	BORCS8-MEF2B readthrough [Source:HGNC Symbol%3BAcc:HGNC:39979]
ENSG00000204977	6.03	7.46	5.39	6.63	5.43	6.92	-0.012154649638825	2.97752272576613	1	1	13:49995887-50020481:+	TRIM13	30;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0004871,molecular_function signal transducer activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0007165,biological_process signal transduction;GO:0008270,molecular_function zinc ion binding;GO:0009653,biological_process anatomical structure morphogenesis;GO:0010332,biological_process response to gamma radiation;GO:0010942,biological_process positive regulation of cell death;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030433,biological_process ER-associated ubiquitin-dependent protein catabolic process;GO:0032897,biological_process negative regulation of viral transcription;GO:0043123,biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043161,biological_process proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044322,cellular_component endoplasmic reticulum quality control compartment;GO:0045087,biological_process innate immune response;GO:0046872,molecular_function metal ion binding;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051865,biological_process protein autoubiquitination;GO:0097038,cellular_component perinuclear endoplasmic reticulum;GO:1902187,biological_process negative regulation of viral release from host cell;GO:1904264,molecular_function ubiquitin protein ligase activity involved in ERAD pathway;GO:1904380,biological_process endoplasmic reticulum mannose trimming	NA	tripartite motif containing 13 [Source:HGNC Symbol%3BAcc:HGNC:9976]
ENSG00000168779	4.64	3.59	4.28	4.43	2.92	5.22	0.0119976251127193	2.21482508925378	1	1	3:158095953-158106503:-	SHOX2	28;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0001501,biological_process skeletal system development;GO:0001649,biological_process osteoblast differentiation;GO:0002053,biological_process positive regulation of mesenchymal cell proliferation;GO:0002062,biological_process chondrocyte differentiation;GO:0002063,biological_process chondrocyte development;GO:0003170,biological_process heart valve development;GO:0003209,biological_process cardiac atrium morphogenesis;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007507,biological_process heart development;GO:0030326,biological_process embryonic limb morphogenesis;GO:0032330,biological_process regulation of chondrocyte differentiation;GO:0035115,biological_process embryonic forelimb morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045880,biological_process positive regulation of smoothened signaling pathway;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0048557,biological_process embryonic digestive tract morphogenesis;GO:0048598,biological_process embryonic morphogenesis;GO:0048743,biological_process positive regulation of skeletal muscle fiber development;GO:0050772,biological_process positive regulation of axonogenesis;GO:0060272,biological_process embryonic skeletal joint morphogenesis;GO:0060351,biological_process cartilage development involved in endochondral bone morphogenesis;GO:0060415,biological_process muscle tissue morphogenesis;GO:2000172,biological_process regulation of branching morphogenesis of a nerve	NA	short stature homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:10854]
ENSG00000177842	1.18	1.88	1.29	1.20	1.21	1.89	-0.0115001156211374	1.08170197471574	1	1	3:40505991-40518736:+	ZNF620	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 620 [Source:HGNC Symbol%3BAcc:HGNC:28742]
ENSG00000099840	4.83	4.12	6.90	4.65	5.38	5.97	0.0113890064009005	2.13016673036323	1	1	19:2096428-2099593:+	IZUMO4	2;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus	NA	IZUMO family member 4 [Source:HGNC Symbol%3BAcc:HGNC:26950]
ENSG00000139832	10.66	11.84	10.90	10.77	8.86	14.12	-0.0112723783119602	3.00288056839267	1	1	13:110523065-110561733:-	RAB20	16;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005525,molecular_function GTP binding;GO:0005769,cellular_component early endosome;GO:0005794,cellular_component Golgi apparatus;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0030100,biological_process regulation of endocytosis;GO:0030670,cellular_component phagocytic vesicle membrane;GO:0031410,cellular_component cytoplasmic vesicle;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0045335,cellular_component phagocytic vesicle;GO:0090383,biological_process phagosome acidification;GO:0090385,biological_process phagosome-lysosome fusion	NA	RAB20%2C member RAS oncogene family [Source:HGNC Symbol%3BAcc:HGNC:18260]
ENSG00000112425	2.84	2.32	2.04	1.98	2.63	2.73	-0.0109394211215972	1.87142284237012	1	1	6:145382534-145736023:-	EPM2A	33;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004722,molecular_function protein serine/threonine phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005829,cellular_component cytosol;GO:0005844,cellular_component polysome;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0005977,biological_process glycogen metabolic process;GO:0005978,biological_process glycogen biosynthetic process;GO:0006470,biological_process protein dephosphorylation;GO:0006914,biological_process autophagy;GO:0007399,biological_process nervous system development;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016020,cellular_component membrane;GO:0016239,biological_process positive regulation of macroautophagy;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0019203,molecular_function carbohydrate phosphatase activity;GO:0030246,molecular_function carbohydrate binding;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0042803,molecular_function protein homodimerization activity;GO:0046838,biological_process phosphorylated carbohydrate dephosphorylation;GO:0046959,biological_process habituation;GO:0098556,cellular_component cytoplasmic side of rough endoplasmic reticulum membrane;GO:2001069,molecular_function glycogen binding;GO:2001070,molecular_function starch binding	NA	EPM2A%2C laforin glucan phosphatase [Source:HGNC Symbol%3BAcc:HGNC:3413]
ENSG00000118997	0.29	0.44	0.45	0.37	0.48	0.35	-0.0107977002328566	2.31386147583633	1	1	2:195737702-196068812:-	DNAH7	22;GO:0000166,molecular_function nucleotide binding;GO:0003341,biological_process cilium movement;GO:0003774,molecular_function motor activity;GO:0003777,molecular_function microtubule motor activity;GO:0005509,molecular_function calcium ion binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005858,cellular_component axonemal dynein complex;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007018,biological_process microtubule-based movement;GO:0008569,molecular_function ATP-dependent microtubule motor activity, minus-end-directed;GO:0030286,cellular_component dynein complex;GO:0036156,cellular_component inner dynein arm;GO:0036159,biological_process inner dynein arm assembly;GO:0042995,cellular_component cell projection;GO:0045503,molecular_function dynein light chain binding;GO:0045505,molecular_function dynein intermediate chain binding;GO:0051959,molecular_function dynein light intermediate chain binding;GO:0060285,biological_process cilium-dependent cell motility	NA	dynein axonemal heavy chain 7 [Source:HGNC Symbol%3BAcc:HGNC:18661]
ENSG00000165164	0.20	0.15	0.22	0.15	0.21	0.23	-0.0107794760664371	1.07134923571833	1	1	X:35919733-36385319:+	CFAP47	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	cilia and flagella associated protein 47 [Source:HGNC Symbol%3BAcc:HGNC:26708]
ENSG00000185900	2.89	2.55	2.38	2.85	2.60	2.41	0.0104750261182224	1.53636956332944	1	1	8:43093505-43123434:+	POMK	20;GO:0000166,molecular_function nucleotide binding;GO:0001764,biological_process neuron migration;GO:0004672,molecular_function protein kinase activity;GO:0005524,molecular_function ATP binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006468,biological_process protein phosphorylation;GO:0006493,biological_process protein O-linked glycosylation;GO:0007420,biological_process brain development;GO:0007611,biological_process learning or memory;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0016773,molecular_function phosphotransferase activity, alcohol group as acceptor;GO:0019200,molecular_function carbohydrate kinase activity;GO:0019233,biological_process sensory perception of pain;GO:0046835,biological_process carbohydrate phosphorylation;GO:0050905,biological_process neuromuscular process	NA	protein-O-mannose kinase [Source:HGNC Symbol%3BAcc:HGNC:26267]
ENSG00000145777	1.93	1.50	4.03	3.08	1.48	3.03	0.0103016432426565	0.541676997670324	1	1	5:111070061-111078024:+	TSLP	3;GO:0005125,molecular_function cytokine activity;GO:0005576,cellular_component extracellular region;GO:0005615,cellular_component extracellular space	TSLP; thymic stromal lymphopoietin; K05436	thymic stromal lymphopoietin [Source:HGNC Symbol%3BAcc:HGNC:30743]
ENSG00000144369	1.85	1.66	1.63	1.72	1.65	1.79	0.0101062367306753	2.14385480305676	1	1	2:186693970-186765965:+	FAM171B	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	family with sequence similarity 171 member B [Source:HGNC Symbol%3BAcc:HGNC:29412]
ENSG00000075886	1.46	2.27	2.29	1.55	2.36	2.14	-0.00996521339497521	1.51190375436788	1	1	2:131476092-131482934:+	TUBA3D	14;GO:0000166,molecular_function nucleotide binding;GO:0003924,molecular_function GTPase activity;GO:0005200,molecular_function structural constituent of cytoskeleton;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005929,cellular_component cilium;GO:0007010,biological_process cytoskeleton organization;GO:0007017,biological_process microtubule-based process;GO:0015630,cellular_component microtubule cytoskeleton;GO:0036064,cellular_component ciliary basal body	NA	tubulin alpha 3d [Source:HGNC Symbol%3BAcc:HGNC:24071]
ENSG00000213397	6.37	8.62	6.81	7.44	7.07	7.37	-0.00967646656544675	3.26628589665269	1	1	X:153447665-153495516:-	HAUS7	17;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0031996,molecular_function thioesterase binding;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 7 [Source:HGNC Symbol%3BAcc:HGNC:32979]
ENSG00000102554	1.34	1.32	1.50	1.47	1.27	1.44	0.00895449305846168	1.04578775959289	1	1	13:73054975-73077542:+	KLF5	30;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001525,biological_process angiogenesis;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0008134,molecular_function transcription factor binding;GO:0008284,biological_process positive regulation of cell proliferation;GO:0030033,biological_process microvillus assembly;GO:0032534,biological_process regulation of microvillus assembly;GO:0035914,biological_process skeletal muscle cell differentiation;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045600,biological_process positive regulation of fat cell differentiation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0060576,biological_process intestinal epithelial cell development;GO:0071407,biological_process cellular response to organic cyclic compound;GO:1901653,biological_process cellular response to peptide;GO:1990830,biological_process cellular response to leukemia inhibitory factor	NA	Kruppel like factor 5 [Source:HGNC Symbol%3BAcc:HGNC:6349]
ENSG00000184208	7.65	6.03	6.56	5.24	9.36	6.08	-0.00883940231240353	2.36198436448476	1	1	22:41688938-41698136:+	C22orf46	1;GO:0005576,cellular_component extracellular region	NA	chromosome 22 open reading frame 46 [Source:HGNC Symbol%3BAcc:HGNC:26294]
ENSG00000108375	0.43	0.65	0.72	0.74	0.60	0.48	-0.00870879097102091	0.795968019620689	1	1	17:58352499-58417595:-	RNF43	20;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005109,molecular_function frizzled binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0030178,biological_process negative regulation of Wnt signaling pathway;GO:0038018,biological_process Wnt receptor catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0072089,biological_process stem cell proliferation	RNF43; RING finger protein 43 [EC:2.3.2.27]; K15694	ring finger protein 43 [Source:HGNC Symbol%3BAcc:HGNC:18505]
ENSG00000115827	5.81	4.39	5.67	5.69	5.72	4.66	0.00861888126984515	3.26143114483122	1	1	2:171434216-171485052:+	DCAF17	9;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005829,cellular_component cytosol;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016567,biological_process protein ubiquitination;GO:0043687,biological_process post-translational protein modification;GO:0080008,cellular_component Cul4-RING E3 ubiquitin ligase complex	NA	DDB1 and CUL4 associated factor 17 [Source:HGNC Symbol%3BAcc:HGNC:25784]
ENSG00000160602	3.06	4.87	4.02	4.12	4.04	3.84	-0.00841389188359959	3.17084233728614	1	1	17:28725896-28743455:+	NEK8	20;GO:0000166,molecular_function nucleotide binding;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005929,cellular_component cilium;GO:0006468,biological_process protein phosphorylation;GO:0007368,biological_process determination of left/right symmetry;GO:0007507,biological_process heart development;GO:0009887,biological_process organ morphogenesis;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0035330,biological_process regulation of hippo signaling;GO:0042995,cellular_component cell projection;GO:0046872,molecular_function metal ion binding;GO:0097543,cellular_component ciliary inversin compartment;GO:0097546,cellular_component ciliary base	NA	NIMA related kinase 8 [Source:HGNC Symbol%3BAcc:HGNC:13387]
ENSG00000165948	24.88	28.23	22.87	26.87	24.89	24.77	-0.00812086010730528	3.55267492416637	1	1	14:94081281-94103846:+	IFI27L1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	interferon alpha inducible protein 27 like 1 [Source:HGNC Symbol%3BAcc:HGNC:19754]
ENSG00000261652	4.47	2.63	2.84	3.71	3.97	2.52	0.00784903326378083	0.465011104959022	1	1	15:55408547-55418764:+	C15orf65	NA	NA	chromosome 15 open reading frame 65 [Source:HGNC Symbol%3BAcc:HGNC:44654]
ENSG00000148943	23.90	21.51	28.39	24.58	26.69	23.20	0.00770622620948169	3.88792585215503	1	1	11:27494575-27506773:-	LIN7C	25;GO:0002011,biological_process morphogenesis of an epithelial sheet;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005911,cellular_component cell-cell junction;GO:0005923,cellular_component bicellular tight junction;GO:0006810,biological_process transport;GO:0006887,biological_process exocytosis;GO:0007269,biological_process neurotransmitter secretion;GO:0008092,molecular_function cytoskeletal protein binding;GO:0014069,cellular_component postsynaptic density;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016323,cellular_component basolateral plasma membrane;GO:0019904,molecular_function protein domain specific binding;GO:0030054,cellular_component cell junction;GO:0030165,molecular_function PDZ domain binding;GO:0043005,cellular_component neuron projection;GO:0045199,biological_process maintenance of epithelial cell apical/basal polarity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0070062,cellular_component extracellular exosome;GO:0097016,molecular_function L27 domain binding;GO:0097025,cellular_component MPP7-DLG1-LIN7 complex;GO:0098793,cellular_component presynapse;GO:1903361,biological_process protein localization to basolateral plasma membrane	NA	lin-7 homolog C%2C crumbs cell polarity complex component [Source:HGNC Symbol%3BAcc:HGNC:17789]
ENSG00000102057	1.50	1.32	2.22	1.92	1.54	1.70	-0.00749059191058127	1.85599300633086	1	1	X:48961377-48971569:-	KCND1	22;GO:0005216,molecular_function ion channel activity;GO:0005244,molecular_function voltage-gated ion channel activity;GO:0005249,molecular_function voltage-gated potassium channel activity;GO:0005250,molecular_function A-type (transient outward) potassium channel activity;GO:0005267,molecular_function potassium channel activity;GO:0005575,cellular_component cellular_component;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006813,biological_process potassium ion transport;GO:0008076,cellular_component voltage-gated potassium channel complex;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030425,cellular_component dendrite;GO:0034765,biological_process regulation of ion transmembrane transport;GO:0042995,cellular_component cell projection;GO:0043025,cellular_component neuronal cell body;GO:0046872,molecular_function metal ion binding;GO:0051260,biological_process protein homooligomerization;GO:0055085,biological_process transmembrane transport;GO:0061337,biological_process cardiac conduction;GO:0071805,biological_process potassium ion transmembrane transport	NA	potassium voltage-gated channel subfamily D member 1 [Source:HGNC Symbol%3BAcc:HGNC:6237]
ENSG00000187630	8.86	8.39	7.05	9.05	7.26	8.26	-0.00693597340599968	2.8672252494286	1	1	14:23969873-24006408:+	DHRS4L2	3;GO:0005576,cellular_component extracellular region;GO:0016491,molecular_function oxidoreductase activity;GO:0055114,biological_process oxidation-reduction process	DHRS4; dehydrogenase/reductase SDR family member 4 [EC:1.1.-.-]; K11147	dehydrogenase/reductase 4 like 2 [Source:HGNC Symbol%3BAcc:HGNC:19731]
ENSG00000198182	5.49	6.01	5.48	5.47	6.14	5.53	-0.00682428217153884	3.63536404951176	1	1	19:37696362-37719790:-	ZNF607	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 607 [Source:HGNC Symbol%3BAcc:HGNC:28192]
ENSG00000134504	27.89	22.24	28.24	29.38	24.80	24.94	0.00667181981349955	4.39951792824799	1	1	18:26454909-26657401:-	KCTD1	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008134,molecular_function transcription factor binding;GO:0042802,molecular_function identical protein binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0051260,biological_process protein homooligomerization	NA	potassium channel tetramerization domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:18249]
ENSG00000243449	14.16	13.19	12.84	12.48	11.85	16.30	-0.00631807873621201	2.41736623875902	1	1	4:2041992-2043970:+	C4orf48	1;GO:0005576,cellular_component extracellular region	NA	chromosome 4 open reading frame 48 [Source:HGNC Symbol%3BAcc:HGNC:34437]
ENSG00000204439	12.73	16.14	13.77	14.69	15.22	13.00	-0.00629987497894328	3.66358837582596	1	1	6:31658297-31660772:-	C6orf47	1;GO:0005829,cellular_component cytosol	NA	chromosome 6 open reading frame 47 [Source:HGNC Symbol%3BAcc:HGNC:19076]
ENSG00000243364	6.20	6.41	6.27	6.47	7.24	5.26	0.00629382675368695	2.33105685473786	1	1	1:155063730-155069553:+	EFNA4	13;GO:0005005,molecular_function transmembrane-ephrin receptor activity;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0007267,biological_process cell-cell signaling;GO:0007411,biological_process axon guidance;GO:0016020,cellular_component membrane;GO:0030316,biological_process osteoclast differentiation;GO:0031225,cellular_component anchored component of membrane;GO:0046849,biological_process bone remodeling;GO:0046875,molecular_function ephrin receptor binding;GO:0048013,biological_process ephrin receptor signaling pathway	EFNA; ephrin-A; K05462	ephrin A4 [Source:HGNC Symbol%3BAcc:HGNC:3224]
ENSG00000160678	7.85	3.75	7.54	8.32	5.78	5.52	0.00599826875100527	1.66090581167723	1	1	1:153627925-153632039:+	S100A1	24;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0002224,biological_process toll-like receptor signaling pathway;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0008016,biological_process regulation of heart contraction;GO:0016529,cellular_component sarcoplasmic reticulum;GO:0021762,biological_process substantia nigra development;GO:0030018,cellular_component Z disc;GO:0031430,cellular_component M band;GO:0031672,cellular_component A band;GO:0031674,cellular_component I band;GO:0035556,biological_process intracellular signal transduction;GO:0042802,molecular_function identical protein binding;GO:0042803,molecular_function protein homodimerization activity;GO:0043005,cellular_component neuron projection;GO:0043234,cellular_component protein complex;GO:0044548,molecular_function S100 protein binding;GO:0046872,molecular_function metal ion binding;GO:0048306,molecular_function calcium-dependent protein binding;GO:0051117,molecular_function ATPase binding;GO:1901387,biological_process positive regulation of voltage-gated calcium channel activity	NA	S100 calcium binding protein A1 [Source:HGNC Symbol%3BAcc:HGNC:10486]
ENSG00000171462	3.87	5.07	4.80	3.97	4.42	5.39	-0.00597180936613198	2.43602309197452	1	1	6:43450351-43456632:-	DLK2	7;GO:0005509,molecular_function calcium ion binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0042803,molecular_function protein homodimerization activity;GO:0045598,biological_process regulation of fat cell differentiation;GO:0045746,biological_process negative regulation of Notch signaling pathway;GO:0070062,cellular_component extracellular exosome	NA	delta like non-canonical Notch ligand 2 [Source:HGNC Symbol%3BAcc:HGNC:21113]
ENSG00000163866	42.47	62.07	50.84	53.77	54.21	48.09	-0.00582134868228021	3.92295345710001	1	1	1:34712736-34859816:-	SMIM12	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	small integral membrane protein 12 [Source:HGNC Symbol%3BAcc:HGNC:25154]
ENSG00000187676	4.92	4.16	4.38	4.36	4.77	4.47	0.00546059134692166	2.7891030311328	1	1	13:31199935-31332276:+	B3GLCT	10;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006004,biological_process fucose metabolic process;GO:0006486,biological_process protein glycosylation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0016757,molecular_function transferase activity, transferring glycosyl groups;GO:0036066,biological_process protein O-linked fucosylation	B3GALTL; UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase [EC:2.4.1.-]; K13675	beta 3-glucosyltransferase [Source:HGNC Symbol%3BAcc:HGNC:20207]
ENSG00000137814	16.66	16.35	17.46	17.67	13.35	20.02	-0.00537626815284976	3.78023768484009	1	1	15:42548809-42569994:+	HAUS2	18;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0005876,cellular_component spindle microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0031023,biological_process microtubule organizing center organization;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 2 [Source:HGNC Symbol%3BAcc:HGNC:25530]
ENSG00000170310	37.81	31.99	37.53	35.22	36.64	36.55	0.00503651546655178	4.68283153212151	1	1	17:9250470-9576591:-	STX8	29;GO:0005484,molecular_function SNAP receptor activity;GO:0005515,molecular_function protein binding;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0005769,cellular_component early endosome;GO:0005770,cellular_component late endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006886,biological_process intracellular protein transport;GO:0006906,biological_process vesicle fusion;GO:0008333,biological_process endosome to lysosome transport;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0019869,molecular_function chloride channel inhibitor activity;GO:0019905,molecular_function syntaxin binding;GO:0031201,cellular_component SNARE complex;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0031902,cellular_component late endosome membrane;GO:0031982,cellular_component vesicle;GO:0045022,biological_process early endosome to late endosome transport;GO:0048278,biological_process vesicle docking;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0055037,cellular_component recycling endosome;GO:0065009,biological_process regulation of molecular function;GO:1903076,biological_process regulation of protein localization to plasma membrane	STX8; syntaxin 8; K08501	syntaxin 8 [Source:HGNC Symbol%3BAcc:HGNC:11443]
ENSG00000167523	11.13	13.83	9.11	10.35	13.29	10.51	-0.00480653218614032	2.84227859575134	1	1	16:89657801-89671272:+	SPATA33	3;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol	NA	spermatogenesis associated 33 [Source:HGNC Symbol%3BAcc:HGNC:26463]
ENSG00000169372	5.31	6.94	5.98	4.43	7.19	6.67	-0.00465032294617234	2.34232981748593	1	1	12:93677374-93894840:+	CRADD	16;GO:0002020,molecular_function protease binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006977,biological_process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007165,biological_process signal transduction;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0030674,molecular_function protein binding, bridging;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0070513,molecular_function death domain binding;GO:0071260,biological_process cellular response to mechanical stimulus;GO:2001235,biological_process positive regulation of apoptotic signaling pathway	NA	CASP2 and RIPK1 domain containing adaptor with death domain [Source:HGNC Symbol%3BAcc:HGNC:2340]
ENSG00000158156	5.84	4.52	4.72	5.18	4.35	5.70	0.00464423895841864	2.62612776703587	1	1	1:27959461-27968096:+	XKR8	6;GO:0005886,cellular_component plasma membrane;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0043652,biological_process engulfment of apoptotic cell;GO:0070782,biological_process phosphatidylserine exposure on apoptotic cell surface	NA	XK related 8 [Source:HGNC Symbol%3BAcc:HGNC:25508]
ENSG00000214357	0.59	0.92	0.66	0.31	0.87	0.97	-0.00454653762105242	0.425571473147388	1	1	5:172641265-172691540:+	NEURL1B	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005769,cellular_component early endosome;GO:0007219,biological_process Notch signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0046872,molecular_function metal ion binding;GO:0070086,biological_process ubiquitin-dependent endocytosis	NA	neuralized E3 ubiquitin protein ligase 1B [Source:HGNC Symbol%3BAcc:HGNC:35422]
ENSG00000120341	3.70	3.26	3.81	3.45	3.45	3.99	0.00445241929912699	3.58986260970382	1	1	1:177923955-177984303:-	SEC16B	17;GO:0000139,cellular_component Golgi membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0007029,biological_process endoplasmic reticulum organization;GO:0007031,biological_process peroxisome organization;GO:0010628,biological_process positive regulation of gene expression;GO:0015031,biological_process protein transport;GO:0016020,cellular_component membrane;GO:0016192,biological_process vesicle-mediated transport;GO:0016559,biological_process peroxisome fission;GO:0043231,cellular_component intracellular membrane-bounded organelle;GO:0048208,biological_process COPII vesicle coating;GO:0070863,biological_process positive regulation of protein exit from endoplasmic reticulum;GO:0070972,biological_process protein localization to endoplasmic reticulum	NA	SEC16 homolog B%2C endoplasmic reticulum export factor [Source:HGNC Symbol%3BAcc:HGNC:30301]
ENSG00000147421	2.61	2.97	2.97	2.92	2.91	2.79	-0.00442350712987094	2.16132391083343	1	1	8:28890393-29064764:+	HMBOX1	25;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0001227,molecular_function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0003677,molecular_function DNA binding;GO:0003691,molecular_function double-stranded telomeric DNA binding;GO:0003720,molecular_function telomerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005697,cellular_component telomerase holoenzyme complex;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006278,biological_process RNA-dependent DNA biosynthetic process;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0016604,cellular_component nuclear body;GO:0032212,biological_process positive regulation of telomere maintenance via telomerase;GO:0032403,molecular_function protein complex binding;GO:0035563,biological_process positive regulation of chromatin binding;GO:0042162,molecular_function telomeric DNA binding;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0051973,biological_process positive regulation of telomerase activity	NA	homeobox containing 1 [Source:HGNC Symbol%3BAcc:HGNC:26137]
ENSG00000143756	21.30	17.14	22.80	19.87	20.27	21.78	0.00440576084841338	4.51838591251989	1	1	1:224114086-224162047:+	FBXO28	5;GO:0000775,cellular_component chromosome, centromeric region;GO:0000776,cellular_component kinetochore;GO:0000777,cellular_component condensed chromosome kinetochore;GO:0005515,molecular_function protein binding;GO:0005694,cellular_component chromosome	NA	F-box protein 28 [Source:HGNC Symbol%3BAcc:HGNC:29046]
ENSG00000268279	14.23	15.89	14.83	16.03	13.95	15.23	-0.00420967941366494	2.61078007360308	1	1	3:14135216-14148252:+	AC090004.1	2;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	NA
ENSG00000214113	30.39	32.75	29.95	31.28	33.71	28.94	-0.00420499800423849	4.32515056107785	1	1	6:5102592-5260939:-	LYRM4	5;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0016604,cellular_component nuclear body;GO:0044281,biological_process small molecule metabolic process	NA	LYR motif containing 4 [Source:HGNC Symbol%3BAcc:HGNC:21365]
ENSG00000100422	11.09	13.11	12.61	11.06	12.99	13.01	-0.00416103442415703	4.31926105570022	1	1	22:46684410-46738261:-	CERK	19;GO:0000166,molecular_function nucleotide binding;GO:0000287,molecular_function magnesium ion binding;GO:0001729,molecular_function ceramide kinase activity;GO:0003951,molecular_function NAD+ kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005886,cellular_component plasma membrane;GO:0006672,biological_process ceramide metabolic process;GO:0006687,biological_process glycosphingolipid metabolic process;GO:0008152,biological_process metabolic process;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0046834,biological_process lipid phosphorylation;GO:0102773,molecular_function dihydroceramide kinase activity	CERK; ceramide kinase [EC:2.7.1.138]; K04715	ceramide kinase [Source:HGNC Symbol%3BAcc:HGNC:19256]
ENSG00000065559	12.92	16.78	16.10	15.58	16.71	13.83	-0.00396524358666523	4.24332152360055	1	1	17:12020823-12143830:+	MAP2K4	43;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004708,molecular_function MAP kinase kinase activity;GO:0004713,molecular_function protein tyrosine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007254,biological_process JNK cascade;GO:0007257,biological_process activation of JUN kinase activity;GO:0007346,biological_process regulation of mitotic cell cycle;GO:0008545,molecular_function JUN kinase kinase activity;GO:0009611,biological_process response to wounding;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018108,biological_process peptidyl-tyrosine phosphorylation;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030424,cellular_component axon;GO:0031098,biological_process stress-activated protein kinase signaling cascade;GO:0031435,molecular_function mitogen-activated protein kinase kinase kinase binding;GO:0032147,biological_process activation of protein kinase activity;GO:0032839,cellular_component dendrite cytoplasm;GO:0034393,biological_process positive regulation of smooth muscle cell apoptotic process;GO:0035897,biological_process proteolysis in other organism;GO:0038095,biological_process Fc-epsilon receptor signaling pathway;GO:0042981,biological_process regulation of apoptotic process;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043204,cellular_component perikaryon;GO:0043525,biological_process positive regulation of neuron apoptotic process;GO:0045740,biological_process positive regulation of DNA replication;GO:0051770,biological_process positive regulation of nitric-oxide synthase biosynthetic process;GO:0061049,biological_process cell growth involved in cardiac muscle cell development;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0072709,biological_process cellular response to sorbitol;GO:2000672,biological_process negative regulation of motor neuron apoptotic process	NA	mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol%3BAcc:HGNC:6844]
ENSG00000089486	8.40	7.79	6.40	6.91	7.71	8.18	-0.00395768509647847	2.53940502273857	1	1	16:4510674-4538828:-	CDIP1	14;GO:0003674,molecular_function molecular_function;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0005768,cellular_component endosome;GO:0006915,biological_process apoptotic process;GO:0016020,cellular_component membrane;GO:0031902,cellular_component late endosome membrane;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0046872,molecular_function metal ion binding;GO:0098560,cellular_component cytoplasmic side of late endosome membrane;GO:0098574,cellular_component cytoplasmic side of lysosomal membrane	NA	cell death inducing p53 target 1 [Source:HGNC Symbol%3BAcc:HGNC:13234]
ENSG00000160051	6.47	6.94	7.64	7.63	6.44	7.08	0.00392214035135501	3.5459794023682	1	1	1:32205660-32208687:+	IQCC	NA	NA	IQ motif containing C [Source:HGNC Symbol%3BAcc:HGNC:25545]
ENSG00000135077	4.77	5.93	5.13	3.73	6.89	5.22	0.00387645026391131	2.29107542112086	1	1	5:157085831-157142869:-	HAVCR2	54;GO:0001772,cellular_component immunological synapse;GO:0001819,biological_process positive regulation of cytokine production;GO:0002250,biological_process adaptive immune response;GO:0002281,biological_process macrophage activation involved in immune response;GO:0002376,biological_process immune system process;GO:0002519,biological_process natural killer cell tolerance induction;GO:0002652,biological_process regulation of tolerance induction dependent upon immune response;GO:0002826,biological_process negative regulation of T-helper 1 type immune response;GO:0002838,biological_process negative regulation of immune response to tumor cell;GO:0002859,biological_process negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0005515,molecular_function protein binding;GO:0005769,cellular_component early endosome;GO:0006954,biological_process inflammatory response;GO:0009986,cellular_component cell surface;GO:0010629,biological_process negative regulation of gene expression;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030054,cellular_component cell junction;GO:0030886,biological_process negative regulation of myeloid dendritic cell activation;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032480,biological_process negative regulation of type I interferon production;GO:0032687,biological_process negative regulation of interferon-alpha production;GO:0032689,biological_process negative regulation of interferon-gamma production;GO:0032703,biological_process negative regulation of interleukin-2 production;GO:0032712,biological_process negative regulation of interleukin-3 production;GO:0032715,biological_process negative regulation of interleukin-6 production;GO:0032720,biological_process negative regulation of tumor necrosis factor production;GO:0032722,biological_process positive regulation of chemokine production;GO:0032729,biological_process positive regulation of interferon-gamma production;GO:0032732,biological_process positive regulation of interleukin-1 production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0032815,biological_process negative regulation of natural killer cell activation;GO:0034138,biological_process toll-like receptor 3 signaling pathway;GO:0034154,biological_process toll-like receptor 7 signaling pathway;GO:0034162,biological_process toll-like receptor 9 signaling pathway;GO:0042102,biological_process positive regulation of T cell proliferation;GO:0042130,biological_process negative regulation of T cell proliferation;GO:0043032,biological_process positive regulation of macrophage activation;GO:0045087,biological_process innate immune response;GO:0045089,biological_process positive regulation of innate immune response;GO:0045824,biological_process negative regulation of innate immune response;GO:0046872,molecular_function metal ion binding;GO:0050830,biological_process defense response to Gram-positive bacterium;GO:0060135,biological_process maternal process involved in female pregnancy;GO:0070062,cellular_component extracellular exosome;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0071656,biological_process negative regulation of granulocyte colony-stimulating factor production;GO:1900425,biological_process negative regulation of defense response to bacterium;GO:1900426,biological_process positive regulation of defense response to bacterium;GO:1901224,biological_process positive regulation of NIK/NF-kappaB signaling;GO:1904469,biological_process positive regulation of tumor necrosis factor secretion;GO:2000521,biological_process negative regulation of immunological synapse formation;GO:2001189,biological_process negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	NA	hepatitis A virus cellular receptor 2 [Source:HGNC Symbol%3BAcc:HGNC:18437]
ENSG00000136367	0.42	0.40	0.36	0.40	0.44	0.36	-0.00383538861593752	1.68044394360508	1	1	14:23520854-23556192:-	ZFHX2	9;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0008270,molecular_function zinc ion binding;GO:0030534,biological_process adult behavior;GO:0043565,molecular_function sequence-specific DNA binding;GO:0046872,molecular_function metal ion binding	NA	zinc finger homeobox 2 [Source:HGNC Symbol%3BAcc:HGNC:20152]
ENSG00000124120	8.33	8.48	9.76	8.32	9.61	8.84	0.00376309791790554	3.21469540440517	1	1	20:44475885-44494603:+	TTPAL	4;GO:0005215,molecular_function transporter activity;GO:0005622,cellular_component intracellular;GO:0006810,biological_process transport;GO:0016020,cellular_component membrane	NA	alpha tocopherol transfer protein like [Source:HGNC Symbol%3BAcc:HGNC:16114]
ENSG00000179943	3.97	4.11	3.99	3.60	4.31	4.21	0.00375549226404197	2.72533254925824	1	1	19:55591370-55601970:-	FIZ1	8;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0003676,molecular_function nucleic acid binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0030971,molecular_function receptor tyrosine kinase binding;GO:0046872,molecular_function metal ion binding	NA	FLT3 interacting zinc finger 1 [Source:HGNC Symbol%3BAcc:HGNC:25917]
ENSG00000277203	3.74	3.61	3.37	3.57	3.82	3.41	0.00371331699649874	2.05055233833127	1	1	X:154886348-154888061:+	F8A1	3;GO:0003674,molecular_function molecular_function;GO:0005634,cellular_component nucleus;GO:0008150,biological_process biological_process	NA	coagulation factor VIII associated 1 [Source:HGNC Symbol%3BAcc:HGNC:3547]
ENSG00000163743	30.56	24.67	28.28	29.77	24.55	30.00	0.0037013097541181	4.54337842446518	1	1	4:75479036-75514764:-	RCHY1	19;GO:0000151,cellular_component ubiquitin ligase complex;GO:0002039,molecular_function p53 binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005102,molecular_function receptor binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0032436,biological_process positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0042803,molecular_function protein homodimerization activity;GO:0046872,molecular_function metal ion binding;GO:0070987,biological_process error-free translesion synthesis	RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]; K10144	ring finger and CHY zinc finger domain containing 1 [Source:HGNC Symbol%3BAcc:HGNC:17479]
ENSG00000119927	3.57	3.87	4.16	3.66	3.99	4.06	-0.00367687003712	3.2991328336437	1	1	10:112149863-112215377:-	GPAM	34;GO:0004366,molecular_function glycerol-3-phosphate O-acyltransferase activity;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005886,cellular_component plasma membrane;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006637,biological_process acyl-CoA metabolic process;GO:0006641,biological_process triglyceride metabolic process;GO:0006650,biological_process glycerophospholipid metabolic process;GO:0006654,biological_process phosphatidic acid biosynthetic process;GO:0008152,biological_process metabolic process;GO:0008374,molecular_function O-acyltransferase activity;GO:0008654,biological_process phospholipid biosynthetic process;GO:0009749,biological_process response to glucose;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016024,biological_process CDP-diacylglycerol biosynthetic process;GO:0016740,molecular_function transferase activity;GO:0016746,molecular_function transferase activity, transferring acyl groups;GO:0019432,biological_process triglyceride biosynthetic process;GO:0031966,cellular_component mitochondrial membrane;GO:0033146,biological_process regulation of intracellular estrogen receptor signaling pathway;GO:0040018,biological_process positive regulation of multicellular organism growth;GO:0042104,biological_process positive regulation of activated T cell proliferation;GO:0044255,biological_process cellular lipid metabolic process;GO:0045540,biological_process regulation of cholesterol biosynthetic process;GO:0050707,biological_process regulation of cytokine secretion;GO:0051607,biological_process defense response to virus;GO:0055089,biological_process fatty acid homeostasis;GO:0055091,biological_process phospholipid homeostasis;GO:0070236,biological_process negative regulation of activation-induced cell death of T cells;GO:0070970,biological_process interleukin-2 secretion;GO:0102420,molecular_function sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]; K00629	glycerol-3-phosphate acyltransferase%2C mitochondrial [Source:HGNC Symbol%3BAcc:HGNC:24865]
ENSG00000197021	22.51	17.32	19.93	22.46	18.49	19.63	0.00365489343012469	3.29688460738028	1	1	X:149929526-149938811:-	CXorf40B	NA	NA	chromosome X open reading frame 40B [Source:HGNC Symbol%3BAcc:HGNC:17402]
ENSG00000188542	4.95	2.71	2.51	3.97	2.15	4.26	-0.00361617169307297	0.990440486123485	1	1	2:240560053-240564014:+	DUSP28	8;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation	NA	dual specificity phosphatase 28 [Source:HGNC Symbol%3BAcc:HGNC:33237]
ENSG00000198042	7.55	6.85	6.65	7.10	6.61	7.60	-0.00358277440587176	2.71610291171505	1	1	8:33484749-33501260:+	MAK16	7;GO:0000460,biological_process maturation of 5.8S rRNA;GO:0000470,biological_process maturation of LSU-rRNA;GO:0003723,molecular_function RNA binding;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0030687,cellular_component preribosome, large subunit precursor;GO:0043231,cellular_component intracellular membrane-bounded organelle	NA	MAK16 homolog [Source:HGNC Symbol%3BAcc:HGNC:13703]
ENSG00000058056	11.32	14.32	11.46	11.94	13.42	11.95	-0.00352591887461935	5.00755837315067	1	1	3:179652754-179789401:+	USP13	32;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0006914,biological_process autophagy;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0008270,molecular_function zinc ion binding;GO:0008283,biological_process cell proliferation;GO:0010506,biological_process regulation of autophagy;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0030318,biological_process melanocyte differentiation;GO:0031625,molecular_function ubiquitin protein ligase binding;GO:0035523,biological_process protein K29-linked deubiquitination;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0043130,molecular_function ubiquitin binding;GO:0044313,biological_process protein K6-linked deubiquitination;GO:0044389,molecular_function ubiquitin-like protein ligase binding;GO:0046872,molecular_function metal ion binding;GO:0050821,biological_process protein stabilization;GO:0051087,molecular_function chaperone binding;GO:0070536,biological_process protein K63-linked deubiquitination;GO:0070628,molecular_function proteasome binding;GO:1904288,molecular_function BAT3 complex binding;GO:1904294,biological_process positive regulation of ERAD pathway;GO:1904378,biological_process maintenance of unfolded protein involved in ERAD pathway;GO:1904454,molecular_function ubiquitin-specific protease activity involved in positive regulation of ERAD pathway	NA	ubiquitin specific peptidase 13 (isopeptidase T-3) [Source:HGNC Symbol%3BAcc:HGNC:12611]
ENSG00000136122	5.06	5.55	4.84	5.51	5.36	4.69	-0.00344243073971483	3.43382072466732	1	1	13:72727748-72756198:+	BORA	10;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0005515,molecular_function protein binding;GO:0005829,cellular_component cytosol;GO:0007049,biological_process cell cycle;GO:0007088,biological_process regulation of mitotic nuclear division;GO:0019901,molecular_function protein kinase binding;GO:0032880,biological_process regulation of protein localization;GO:0051301,biological_process cell division;GO:0060236,biological_process regulation of mitotic spindle organization;GO:0072687,cellular_component meiotic spindle	NA	bora%2C aurora kinase A activator [Source:HGNC Symbol%3BAcc:HGNC:24724]
ENSG00000225828	8.61	6.06	6.82	7.30	6.10	8.40	0.0034277082825322	1.65001256366014	1	1	1:32361269-32364278:-	FAM229A	NA	NA	family with sequence similarity 229 member A [Source:HGNC Symbol%3BAcc:HGNC:44652]
ENSG00000156050	4.19	4.40	4.17	3.76	4.36	4.72	-0.00332578483954632	3.23644244290356	1	1	14:73931500-73950414:-	FAM161B	NA	NA	family with sequence similarity 161 member B [Source:HGNC Symbol%3BAcc:HGNC:19854]
ENSG00000185880	1.41	1.53	1.77	1.30	2.48	0.98	0.00329633534012952	1.32738054838545	1	1	15:44728987-44767829:+	TRIM69	11;GO:0000209,biological_process protein polyubiquitination;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006915,biological_process apoptotic process;GO:0016567,biological_process protein ubiquitination;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0046872,molecular_function metal ion binding	NA	tripartite motif containing 69 [Source:HGNC Symbol%3BAcc:HGNC:17857]
ENSG00000139618	1.21	1.14	1.48	1.11	1.47	1.28	0.00326200153323498	3.76053795043439	1	1	13:32315473-32400266:+	BRCA2	58;GO:0000722,biological_process telomere maintenance via recombination;GO:0000724,biological_process double-strand break repair via homologous recombination;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0000784,cellular_component nuclear chromosome, telomeric region;GO:0000800,cellular_component lateral element;GO:0000910,biological_process cytokinesis;GO:0001556,biological_process oocyte maturation;GO:0001833,biological_process inner cell mass cell proliferation;GO:0002020,molecular_function protease binding;GO:0003677,molecular_function DNA binding;GO:0003697,molecular_function single-stranded DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006281,biological_process DNA repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006302,biological_process double-strand break repair;GO:0006310,biological_process DNA recombination;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006978,biological_process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007049,biological_process cell cycle;GO:0007141,biological_process male meiosis I;GO:0007283,biological_process spermatogenesis;GO:0007420,biological_process brain development;GO:0007569,biological_process cell aging;GO:0008022,molecular_function protein C-terminus binding;GO:0008283,biological_process cell proliferation;GO:0008585,biological_process female gonad development;GO:0008630,biological_process intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010165,biological_process response to X-ray;GO:0010225,biological_process response to UV-C;GO:0010332,biological_process response to gamma radiation;GO:0010484,molecular_function H3 histone acetyltransferase activity;GO:0010485,molecular_function H4 histone acetyltransferase activity;GO:0030097,biological_process hemopoiesis;GO:0030141,cellular_component secretory granule;GO:0032465,biological_process regulation of cytokinesis;GO:0033593,cellular_component BRCA2-MAGE-D1 complex;GO:0033600,biological_process negative regulation of mammary gland epithelial cell proliferation;GO:0042771,biological_process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043009,biological_process chordate embryonic development;GO:0043015,molecular_function gamma-tubulin binding;GO:0043234,cellular_component protein complex;GO:0043966,biological_process histone H3 acetylation;GO:0043967,biological_process histone H4 acetylation;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045931,biological_process positive regulation of mitotic cell cycle;GO:0048478,biological_process replication fork protection;GO:0051276,biological_process chromosome organization;GO:0051298,biological_process centrosome duplication;GO:0070200,biological_process establishment of protein localization to telomere;GO:1990426,biological_process mitotic recombination-dependent replication fork processing	BRCA2, FANCD1; breast cancer 2 susceptibility protein; K08775	BRCA2%2C DNA repair associated [Source:HGNC Symbol%3BAcc:HGNC:1101]
ENSG00000162711	0.34	0.34	0.26	0.43	0.12	0.38	-0.00325404244773166	0.172839023281196	1	1	1:247416155-247449108:+	NLRP3	49;GO:0000166,molecular_function nucleotide binding;GO:0002376,biological_process immune system process;GO:0002674,biological_process negative regulation of acute inflammatory response;GO:0002830,biological_process positive regulation of type 2 immune response;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005576,cellular_component extracellular region;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006952,biological_process defense response;GO:0006954,biological_process inflammatory response;GO:0007165,biological_process signal transduction;GO:0008134,molecular_function transcription factor binding;GO:0009595,biological_process detection of biotic stimulus;GO:0016579,biological_process protein deubiquitination;GO:0032088,biological_process negative regulation of NF-kappaB transcription factor activity;GO:0032611,biological_process interleukin-1 beta production;GO:0032621,biological_process interleukin-18 production;GO:0032736,biological_process positive regulation of interleukin-13 production;GO:0032753,biological_process positive regulation of interleukin-4 production;GO:0032754,biological_process positive regulation of interleukin-5 production;GO:0042347,biological_process negative regulation of NF-kappaB import into nucleus;GO:0042802,molecular_function identical protein binding;GO:0042834,molecular_function peptidoglycan binding;GO:0043280,biological_process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043565,molecular_function sequence-specific DNA binding;GO:0044546,biological_process NLRP3 inflammasome complex assembly;GO:0045087,biological_process innate immune response;GO:0045630,biological_process positive regulation of T-helper 2 cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0050701,biological_process interleukin-1 secretion;GO:0050713,biological_process negative regulation of interleukin-1 beta secretion;GO:0050718,biological_process positive regulation of interleukin-1 beta secretion;GO:0050727,biological_process regulation of inflammatory response;GO:0050728,biological_process negative regulation of inflammatory response;GO:0051092,biological_process positive regulation of NF-kappaB transcription factor activity;GO:0051259,biological_process protein oligomerization;GO:0051607,biological_process defense response to virus;GO:0061702,cellular_component inflammasome complex;GO:0071222,biological_process cellular response to lipopolysaccharide;GO:0072559,cellular_component NLRP3 inflammasome complex;GO:2000321,biological_process positive regulation of T-helper 17 cell differentiation;GO:2000553,biological_process positive regulation of T-helper 2 cell cytokine production	NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3; K12800	NLR family pyrin domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:16400]
ENSG00000126803	3.06	3.84	2.69	3.32	3.52	2.71	0.00323896517948051	2.6366443357898	1	1	14:64535904-64546173:+	HSPA2	37;GO:0000166,molecular_function nucleotide binding;GO:0000795,cellular_component synaptonemal complex;GO:0001673,cellular_component male germ cell nucleus;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006986,biological_process response to unfolded protein;GO:0007140,biological_process male meiosis;GO:0007141,biological_process male meiosis I;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0009408,biological_process response to heat;GO:0009409,biological_process response to cold;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0031662,biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle;GO:0032781,biological_process positive regulation of ATPase activity;GO:0036128,cellular_component CatSper complex;GO:0042026,biological_process protein refolding;GO:0043209,cellular_component myelin sheath;GO:0051082,molecular_function unfolded protein binding;GO:0051861,molecular_function glycolipid binding;GO:0070062,cellular_component extracellular exosome;GO:0070194,biological_process synaptonemal complex disassembly;GO:0072562,cellular_component blood microparticle;GO:0072687,cellular_component meiotic spindle;GO:0090084,biological_process negative regulation of inclusion body assembly;GO:0097718,molecular_function disordered domain specific binding;GO:1901896,biological_process positive regulation of calcium-transporting ATPase activity	NA	heat shock protein family A (Hsp70) member 2 [Source:HGNC Symbol%3BAcc:HGNC:5235]
ENSG00000135436	0.77	0.50	0.54	0.63	0.61	0.62	-0.00298044576362823	0.934887394375715	1	1	12:49582884-49605639:-	FAM186B	1;GO:0043234,cellular_component protein complex	NA	family with sequence similarity 186 member B [Source:HGNC Symbol%3BAcc:HGNC:25296]
ENSG00000004779	69.14	76.71	67.96	70.86	73.81	70.59	-0.00287435543403835	5.22677483873367	1	1	16:23581001-23596356:-	NDUFAB1	25;GO:0000035,molecular_function acyl binding;GO:0000036,molecular_function ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process;GO:0005504,molecular_function fatty acid binding;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0005747,cellular_component mitochondrial respiratory chain complex I;GO:0005759,cellular_component mitochondrial matrix;GO:0005829,cellular_component cytosol;GO:0006120,biological_process mitochondrial electron transport, NADH to ubiquinone;GO:0006629,biological_process lipid metabolic process;GO:0006631,biological_process fatty acid metabolic process;GO:0006633,biological_process fatty acid biosynthetic process;GO:0006635,biological_process fatty acid beta-oxidation;GO:0008137,molecular_function NADH dehydrogenase (ubiquinone) activity;GO:0009245,biological_process lipid A biosynthetic process;GO:0009249,biological_process protein lipoylation;GO:0031177,molecular_function phosphopantetheine binding;GO:0031966,cellular_component mitochondrial membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0034641,biological_process cellular nitrogen compound metabolic process;GO:0055114,biological_process oxidation-reduction process;GO:0070469,cellular_component respiratory chain	NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein; K03955	NADH:ubiquinone oxidoreductase subunit AB1 [Source:HGNC Symbol%3BAcc:HGNC:7694]
ENSG00000083097	3.95	3.65	3.77	3.66	4.27	3.55	0.00282718516905578	4.83653942917516	1	1	6:83067665-83171350:+	DOPEY1	8;GO:0000139,cellular_component Golgi membrane;GO:0005768,cellular_component endosome;GO:0005802,cellular_component trans-Golgi network;GO:0005829,cellular_component cytosol;GO:0006810,biological_process transport;GO:0006895,biological_process Golgi to endosome transport;GO:0007029,biological_process endoplasmic reticulum organization;GO:0015031,biological_process protein transport	NA	dopey family member 1 [Source:HGNC Symbol%3BAcc:HGNC:21194]
ENSG00000197429	7.04	7.24	6.54	6.32	6.78	7.84	-0.00271518537962637	3.70141607458963	1	1	1:45694323-45750650:-	IPP	7;GO:0003779,molecular_function actin binding;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0015629,cellular_component actin cytoskeleton;GO:0016567,biological_process protein ubiquitination;GO:0031463,cellular_component Cul3-RING ubiquitin ligase complex	NA	intracisternal A particle-promoted polypeptide [Source:HGNC Symbol%3BAcc:HGNC:6108]
ENSG00000170379	0.29	0.27	0.40	0.17	0.38	0.42	-0.00261395699775613	0.235937031660773	1	1	7:143620949-143730409:+	TCAF2	7;GO:0005886,cellular_component plasma membrane;GO:0006810,biological_process transport;GO:0010360,biological_process negative regulation of anion channel activity;GO:0016020,cellular_component membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0044325,molecular_function ion channel binding;GO:0090314,biological_process positive regulation of protein targeting to membrane	NA	TRPM8 channel associated factor 2 [Source:HGNC Symbol%3BAcc:HGNC:26878]
ENSG00000151413	8.90	9.23	10.56	9.64	9.91	9.38	0.00257066694990364	3.40629575303373	1	1	14:31489955-31861224:+	NUBPL	10;GO:0000166,molecular_function nucleotide binding;GO:0005524,molecular_function ATP binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0005886,cellular_component plasma membrane;GO:0032981,biological_process mitochondrial respiratory chain complex I assembly;GO:0046872,molecular_function metal ion binding;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0070584,biological_process mitochondrion morphogenesis	NA	nucleotide binding protein like [Source:HGNC Symbol%3BAcc:HGNC:20278]
ENSG00000166477	10.43	11.14	10.17	9.63	10.48	11.83	-0.00253987987767142	4.4162627497697	1	1	15:51938024-51971806:-	LEO1	24;GO:0001650,cellular_component fibrillar center;GO:0001711,biological_process endodermal cell fate commitment;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005813,cellular_component centrosome;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006378,biological_process mRNA polyadenylation;GO:0010390,biological_process histone monoubiquitination;GO:0016055,biological_process Wnt signaling pathway;GO:0016567,biological_process protein ubiquitination;GO:0016570,biological_process histone modification;GO:0016593,cellular_component Cdc73/Paf1 complex;GO:0019827,biological_process stem cell population maintenance;GO:0031442,biological_process positive regulation of mRNA 3'-end processing;GO:0032968,biological_process positive regulation of transcription elongation from RNA polymerase II promoter;GO:0033523,biological_process histone H2B ubiquitination;GO:0045638,biological_process negative regulation of myeloid cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:1904837,biological_process beta-catenin-TCF complex assembly;GO:1990269,molecular_function RNA polymerase II C-terminal domain phosphoserine binding	NA	LEO1 homolog%2C Paf1/RNA polymerase II complex component [Source:HGNC Symbol%3BAcc:HGNC:30401]
ENSG00000133083	0.98	1.05	0.96	1.20	0.87	0.95	-0.00242653740360873	1.33415672768527	1	1	13:35768651-36131306:-	DCLK1	30;GO:0000166,molecular_function nucleotide binding;GO:0001764,biological_process neuron migration;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005887,cellular_component integral component of plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0007275,biological_process multicellular organism development;GO:0007399,biological_process nervous system development;GO:0007409,biological_process axonogenesis;GO:0007417,biological_process central nervous system development;GO:0007420,biological_process brain development;GO:0009615,biological_process response to virus;GO:0014069,cellular_component postsynaptic density;GO:0016197,biological_process endosomal transport;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016740,molecular_function transferase activity;GO:0018105,biological_process peptidyl-serine phosphorylation;GO:0018107,biological_process peptidyl-threonine phosphorylation;GO:0021952,biological_process central nervous system projection neuron axonogenesis;GO:0030154,biological_process cell differentiation;GO:0030900,biological_process forebrain development;GO:0035556,biological_process intracellular signal transduction;GO:0048675,biological_process axon extension;GO:0048812,biological_process neuron projection morphogenesis;GO:0048813,biological_process dendrite morphogenesis;GO:1900181,biological_process negative regulation of protein localization to nucleus	NA	doublecortin like kinase 1 [Source:HGNC Symbol%3BAcc:HGNC:2700]
ENSG00000237440	2.40	3.25	3.42	2.55	3.95	2.61	0.0023616858364892	2.58485110386719	1	1	19:20535824-20565809:-	ZNF737	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 737 [Source:HGNC Symbol%3BAcc:HGNC:32468]
ENSG00000136492	3.37	3.38	3.28	3.15	3.30	3.66	-0.0022948999838921	3.77100831488762	1	1	17:61681265-61863521:-	BRIP1	44;GO:0000077,biological_process DNA damage checkpoint;GO:0000166,molecular_function nucleotide binding;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006260,biological_process DNA replication;GO:0006281,biological_process DNA repair;GO:0006302,biological_process double-strand break repair;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0007129,biological_process synapsis;GO:0007283,biological_process spermatogenesis;GO:0007284,biological_process spermatogonial cell division;GO:0007286,biological_process spermatid development;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0008285,biological_process negative regulation of cell proliferation;GO:0008584,biological_process male gonad development;GO:0009636,biological_process response to toxic substance;GO:0010629,biological_process negative regulation of gene expression;GO:0010705,biological_process meiotic DNA double-strand break processing involved in reciprocal meiotic recombination;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0031965,cellular_component nuclear membrane;GO:0032508,biological_process DNA duplex unwinding;GO:0046872,molecular_function metal ion binding;GO:0051026,biological_process chiasma assembly;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0071295,biological_process cellular response to vitamin;GO:0071456,biological_process cellular response to hypoxia;GO:0072520,biological_process seminiferous tubule development;GO:1901796,biological_process regulation of signal transduction by p53 class mediator;GO:1904385,biological_process cellular response to angiotensin;GO:1990918,biological_process double-strand break repair involved in meiotic recombination	BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:3.6.4.12]; K15362	BRCA1 interacting protein C-terminal helicase 1 [Source:HGNC Symbol%3BAcc:HGNC:20473]
ENSG00000139318	3.08	3.44	2.96	3.08	2.99	3.43	-0.00222648470471092	1.94080030802504	1	1	12:89347231-89353271:-	DUSP6	29;GO:0000165,biological_process MAPK cascade;GO:0000187,biological_process activation of MAPK activity;GO:0000188,biological_process inactivation of MAPK activity;GO:0001933,biological_process negative regulation of protein phosphorylation;GO:0004721,molecular_function phosphoprotein phosphatase activity;GO:0004725,molecular_function protein tyrosine phosphatase activity;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006470,biological_process protein dephosphorylation;GO:0008138,molecular_function protein tyrosine/serine/threonine phosphatase activity;GO:0009953,biological_process dorsal/ventral pattern formation;GO:0010033,biological_process response to organic substance;GO:0010942,biological_process positive regulation of cell death;GO:0014070,biological_process response to organic cyclic compound;GO:0016311,biological_process dephosphorylation;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0017017,molecular_function MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0030154,biological_process cell differentiation;GO:0035335,biological_process peptidyl-tyrosine dephosphorylation;GO:0040036,biological_process regulation of fibroblast growth factor receptor signaling pathway;GO:0042493,biological_process response to drug;GO:0042663,biological_process regulation of endodermal cell fate specification;GO:0043065,biological_process positive regulation of apoptotic process;GO:0051409,biological_process response to nitrosative stress;GO:0060420,biological_process regulation of heart growth;GO:0070373,biological_process negative regulation of ERK1 and ERK2 cascade;GO:0070848,biological_process response to growth factor	DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]; K04459	dual specificity phosphatase 6 [Source:HGNC Symbol%3BAcc:HGNC:3072]
ENSG00000108515	6.35	7.76	7.78	7.16	6.92	7.89	-0.00215364124654301	3.36535005862296	1	1	17:4948091-4957131:+	ENO3	15;GO:0000015,cellular_component phosphopyruvate hydratase complex;GO:0000287,molecular_function magnesium ion binding;GO:0004634,molecular_function phosphopyruvate hydratase activity;GO:0005615,cellular_component extracellular space;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006094,biological_process gluconeogenesis;GO:0006096,biological_process glycolytic process;GO:0016020,cellular_component membrane;GO:0016829,molecular_function lyase activity;GO:0021762,biological_process substantia nigra development;GO:0046872,molecular_function metal ion binding;GO:0061621,biological_process canonical glycolysis;GO:0070062,cellular_component extracellular exosome	ENO, eno; enolase [EC:4.2.1.11]; K01689	enolase 3 [Source:HGNC Symbol%3BAcc:HGNC:3354]
ENSG00000170175	5.24	3.51	3.13	4.60	4.04	3.43	-0.0020818178951223	2.6959273487788	1	1	17:7445060-7457707:+	CHRNB1	32;GO:0001941,biological_process postsynaptic membrane organization;GO:0003009,biological_process skeletal muscle contraction;GO:0005216,molecular_function ion channel activity;GO:0005230,molecular_function extracellular ligand-gated ion channel activity;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005892,cellular_component acetylcholine-gated channel complex;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006812,biological_process cation transport;GO:0006936,biological_process muscle contraction;GO:0007165,biological_process signal transduction;GO:0007271,biological_process synaptic transmission, cholinergic;GO:0007274,biological_process neuromuscular synaptic transmission;GO:0015267,molecular_function channel activity;GO:0015276,molecular_function ligand-gated ion channel activity;GO:0015464,molecular_function acetylcholine receptor activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0022848,molecular_function acetylcholine-gated cation channel activity;GO:0030054,cellular_component cell junction;GO:0034220,biological_process ion transmembrane transport;GO:0035095,biological_process behavioral response to nicotine;GO:0042166,molecular_function acetylcholine binding;GO:0042391,biological_process regulation of membrane potential;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0048747,biological_process muscle fiber development;GO:0050877,biological_process neurological system process;GO:0060078,biological_process regulation of postsynaptic membrane potential;GO:0060079,biological_process excitatory postsynaptic potential;GO:0098655,biological_process cation transmembrane transport	CHRNB1; nicotinic acetylcholine receptor beta-1; K04812	cholinergic receptor nicotinic beta 1 subunit [Source:HGNC Symbol%3BAcc:HGNC:1961]
ENSG00000165113	7.85	7.62	7.39	7.45	6.12	9.39	0.0020644480907522	3.12013408166378	1	1	9:83739420-83829516:-	GKAP1	6;GO:0005515,molecular_function protein binding;GO:0005794,cellular_component Golgi apparatus;GO:0007165,biological_process signal transduction;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0042802,molecular_function identical protein binding	NA	G kinase anchoring protein 1 [Source:HGNC Symbol%3BAcc:HGNC:17496]
ENSG00000143842	4.78	5.00	6.42	5.46	4.73	6.13	0.00197137800269147	3.3840671388046	1	1	1:204073114-204127743:+	SOX13	11;GO:0000977,molecular_function RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0009653,biological_process anatomical structure morphogenesis;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045586,biological_process regulation of gamma-delta T cell differentiation	NA	SRY-box 13 [Source:HGNC Symbol%3BAcc:HGNC:11192]
ENSG00000136048	25.97	22.44	22.79	23.28	24.17	24.50	0.00182453470654458	4.22394891765093	1	1	12:101877350-102012130:+	DRAM1	9;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005764,cellular_component lysosome;GO:0005765,cellular_component lysosomal membrane;GO:0006914,biological_process autophagy;GO:0006915,biological_process apoptotic process;GO:0010506,biological_process regulation of autophagy;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	DNA damage regulated autophagy modulator 1 [Source:HGNC Symbol%3BAcc:HGNC:25645]
ENSG00000125454	5.11	5.50	5.77	4.68	6.85	5.02	-0.00182299854337419	2.50525880875739	1	1	17:75272980-75289510:-	SLC25A19	16;GO:0005634,cellular_component nucleus;GO:0005739,cellular_component mitochondrion;GO:0005743,cellular_component mitochondrial inner membrane;GO:0006810,biological_process transport;GO:0006839,biological_process mitochondrial transport;GO:0015234,molecular_function thiamine transmembrane transporter activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0030233,molecular_function deoxynucleotide transmembrane transporter activity;GO:0030302,biological_process deoxynucleotide transport;GO:0030974,biological_process thiamine pyrophosphate transport;GO:0031305,cellular_component integral component of mitochondrial inner membrane;GO:0042723,biological_process thiamine-containing compound metabolic process;GO:0055085,biological_process transmembrane transport;GO:0071934,biological_process thiamine transmembrane transport;GO:0090422,molecular_function thiamine pyrophosphate transporter activity	NA	solute carrier family 25 member 19 [Source:HGNC Symbol%3BAcc:HGNC:14409]
ENSG00000148297	31.18	31.80	33.83	31.45	34.86	31.28	0.00180190887167104	4.30954914981695	1	1	9:133338322-133348131:-	MED22	8;GO:0001104,molecular_function RNA polymerase II transcription cofactor activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0016592,cellular_component mediator complex	NA	mediator complex subunit 22 [Source:HGNC Symbol%3BAcc:HGNC:11477]
ENSG00000065970	10.86	10.35	12.02	12.23	10.24	11.09	0.00170168946382852	4.30879392006306	1	1	12:8032702-8055503:+	FOXJ2	15;GO:0000978,molecular_function RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077,molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001650,cellular_component fibrillar center;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0009653,biological_process anatomical structure morphogenesis;GO:0030154,biological_process cell differentiation;GO:0042802,molecular_function identical protein binding;GO:0043565,molecular_function sequence-specific DNA binding;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter	NA	forkhead box J2 [Source:HGNC Symbol%3BAcc:HGNC:24818]
ENSG00000147119	3.63	2.29	2.57	2.41	2.39	3.81	0.00168408750018697	2.12491362794573	1	1	X:46573783-46598408:+	CHST7	13;GO:0000139,cellular_component Golgi membrane;GO:0001517,molecular_function N-acetylglucosamine 6-O-sulfotransferase activity;GO:0005794,cellular_component Golgi apparatus;GO:0005975,biological_process carbohydrate metabolic process;GO:0005976,biological_process polysaccharide metabolic process;GO:0006044,biological_process N-acetylglucosamine metabolic process;GO:0006790,biological_process sulfur compound metabolic process;GO:0008146,molecular_function sulfotransferase activity;GO:0008459,molecular_function chondroitin 6-sulfotransferase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016740,molecular_function transferase activity;GO:0030206,biological_process chondroitin sulfate biosynthetic process	CHST7; chondroitin 6-sulfotransferase 7 [EC:2.8.2.17]; K04743	carbohydrate sulfotransferase 7 [Source:HGNC Symbol%3BAcc:HGNC:13817]
ENSG00000180902	12.14	12.80	13.94	13.68	11.43	14.11	-0.00165962710529119	4.86008156789551	1	1	2:241734578-241768816:+	D2HGDH	17;GO:0003824,molecular_function catalytic activity;GO:0004458,molecular_function D-lactate dehydrogenase (cytochrome) activity;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0006103,biological_process 2-oxoglutarate metabolic process;GO:0010042,biological_process response to manganese ion;GO:0010043,biological_process response to zinc ion;GO:0016491,molecular_function oxidoreductase activity;GO:0016614,molecular_function oxidoreductase activity, acting on CH-OH group of donors;GO:0019516,biological_process lactate oxidation;GO:0022904,biological_process respiratory electron transport chain;GO:0032025,biological_process response to cobalt ion;GO:0044267,biological_process cellular protein metabolic process;GO:0050660,molecular_function flavin adenine dinucleotide binding;GO:0051990,molecular_function (R)-2-hydroxyglutarate dehydrogenase activity;GO:0055114,biological_process oxidation-reduction process;GO:0071949,molecular_function FAD binding	NA	D-2-hydroxyglutarate dehydrogenase [Source:HGNC Symbol%3BAcc:HGNC:28358]
ENSG00000180376	10.73	9.36	9.87	10.11	10.22	9.95	0.0016577678083941	4.90408979052075	1	1	3:56557160-56621818:+	CCDC66	NA	NA	coiled-coil domain containing 66 [Source:HGNC Symbol%3BAcc:HGNC:27709]
ENSG00000101868	6.91	7.01	6.38	6.41	6.89	7.15	-0.00162194687454461	4.91027524760058	1	1	X:24693918-24996986:+	POLA1	38;GO:0000082,biological_process G1/S transition of mitotic cell cycle;GO:0000083,biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0000166,molecular_function nucleotide binding;GO:0000785,cellular_component chromatin;GO:0001882,molecular_function nucleoside binding;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0003887,molecular_function DNA-directed DNA polymerase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005635,cellular_component nuclear envelope;GO:0005654,cellular_component nucleoplasm;GO:0005658,cellular_component alpha DNA polymerase:primase complex;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0006269,biological_process DNA replication, synthesis of RNA primer;GO:0006270,biological_process DNA replication initiation;GO:0006271,biological_process DNA strand elongation involved in DNA replication;GO:0006272,biological_process leading strand elongation;GO:0006273,biological_process lagging strand elongation;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0008283,biological_process cell proliferation;GO:0008408,molecular_function 3'-5' exonuclease activity;GO:0016032,biological_process viral process;GO:0016363,cellular_component nuclear matrix;GO:0016740,molecular_function transferase activity;GO:0016779,molecular_function nucleotidyltransferase activity;GO:0019901,molecular_function protein kinase binding;GO:0032201,biological_process telomere maintenance via semi-conservative replication;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0071897,biological_process DNA biosynthetic process;GO:0090305,biological_process nucleic acid phosphodiester bond hydrolysis	POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]; K02320	DNA polymerase alpha 1%2C catalytic subunit [Source:HGNC Symbol%3BAcc:HGNC:9173]
ENSG00000196646	4.97	5.78	5.04	6.15	4.45	5.25	-0.00160426485466586	3.11650147743486	1	1	19:12163063-12189881:+	ZNF136	11;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003714,molecular_function transcription corepressor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 136 [Source:HGNC Symbol%3BAcc:HGNC:12920]
ENSG00000204217	13.53	12.71	14.22	13.07	13.54	14.22	0.00160256105177092	5.40957286621732	1	1	2:202376935-202567751:+	BMPR2	86;GO:0000166,molecular_function nucleotide binding;GO:0001707,biological_process mesoderm formation;GO:0001893,biological_process maternal placenta development;GO:0001935,biological_process endothelial cell proliferation;GO:0001938,biological_process positive regulation of endothelial cell proliferation;GO:0001946,biological_process lymphangiogenesis;GO:0001974,biological_process blood vessel remodeling;GO:0002063,biological_process chondrocyte development;GO:0003085,biological_process negative regulation of systemic arterial blood pressure;GO:0003148,biological_process outflow tract septum morphogenesis;GO:0003151,biological_process outflow tract morphogenesis;GO:0003183,biological_process mitral valve morphogenesis;GO:0003186,biological_process tricuspid valve morphogenesis;GO:0003197,biological_process endocardial cushion development;GO:0003252,biological_process negative regulation of cell proliferation involved in heart valve morphogenesis;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004675,molecular_function transmembrane receptor protein serine/threonine kinase activity;GO:0004702,molecular_function receptor signaling protein serine/threonine kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005615,cellular_component extracellular space;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0005901,cellular_component caveola;GO:0005913,cellular_component cell-cell adherens junction;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006468,biological_process protein phosphorylation;GO:0007178,biological_process transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007420,biological_process brain development;GO:0009267,biological_process cellular response to starvation;GO:0009925,cellular_component basal plasma membrane;GO:0009952,biological_process anterior/posterior pattern specification;GO:0009986,cellular_component cell surface;GO:0010595,biological_process positive regulation of endothelial cell migration;GO:0010634,biological_process positive regulation of epithelial cell migration;GO:0010862,biological_process positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0014069,cellular_component postsynaptic density;GO:0014916,biological_process regulation of lung blood pressure;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016324,cellular_component apical plasma membrane;GO:0016362,molecular_function activin receptor activity, type II;GO:0016740,molecular_function transferase activity;GO:0019838,molecular_function growth factor binding;GO:0023014,biological_process signal transduction by protein phosphorylation;GO:0030166,biological_process proteoglycan biosynthetic process;GO:0030308,biological_process negative regulation of cell growth;GO:0030425,cellular_component dendrite;GO:0030501,biological_process positive regulation of bone mineralization;GO:0030509,biological_process BMP signaling pathway;GO:0030513,biological_process positive regulation of BMP signaling pathway;GO:0032924,biological_process activin receptor signaling pathway;GO:0036122,molecular_function BMP binding;GO:0042127,biological_process regulation of cell proliferation;GO:0043025,cellular_component neuronal cell body;GO:0044214,cellular_component spanning component of plasma membrane;GO:0045669,biological_process positive regulation of osteoblast differentiation;GO:0045778,biological_process positive regulation of ossification;GO:0045906,biological_process negative regulation of vasoconstriction;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0048010,biological_process vascular endothelial growth factor receptor signaling pathway;GO:0048286,biological_process lung alveolus development;GO:0048842,biological_process positive regulation of axon extension involved in axon guidance;GO:0060041,biological_process retina development in camera-type eye;GO:0060173,biological_process limb development;GO:0060350,biological_process endochondral bone morphogenesis;GO:0060412,biological_process ventricular septum morphogenesis;GO:0060413,biological_process atrial septum morphogenesis;GO:0060836,biological_process lymphatic endothelial cell differentiation;GO:0060840,biological_process artery development;GO:0060841,biological_process venous blood vessel development;GO:0061036,biological_process positive regulation of cartilage development;GO:0061298,biological_process retina vasculature development in camera-type eye;GO:0061626,biological_process pharyngeal arch artery morphogenesis;GO:0071773,biological_process cellular response to BMP stimulus;GO:0072577,biological_process endothelial cell apoptotic process;GO:0098821,molecular_function BMP receptor activity;GO:1902731,biological_process negative regulation of chondrocyte proliferation;GO:1905314,biological_process semi-lunar valve development;GO:2000279,biological_process negative regulation of DNA biosynthetic process	BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]; K04671	bone morphogenetic protein receptor type 2 [Source:HGNC Symbol%3BAcc:HGNC:1078]
ENSG00000141644	18.63	20.73	20.40	21.30	19.35	19.56	-0.00158381998341079	5.47801445746725	1	1	18:50266881-50281774:-	MBD1	28;GO:0000790,cellular_component nuclear chromatin;GO:0003677,molecular_function DNA binding;GO:0003682,molecular_function chromatin binding;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005694,cellular_component chromosome;GO:0005737,cellular_component cytoplasm;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0007507,biological_process heart development;GO:0007568,biological_process aging;GO:0008270,molecular_function zinc ion binding;GO:0008327,molecular_function methyl-CpG binding;GO:0010385,molecular_function double-stranded methylated DNA binding;GO:0010629,biological_process negative regulation of gene expression;GO:0014070,biological_process response to organic cyclic compound;GO:0016363,cellular_component nuclear matrix;GO:0016607,cellular_component nuclear speck;GO:0030182,biological_process neuron differentiation;GO:0031667,biological_process response to nutrient levels;GO:0032355,biological_process response to estradiol;GO:0042220,biological_process response to cocaine;GO:0042493,biological_process response to drug;GO:0044030,biological_process regulation of DNA methylation;GO:0045892,biological_process negative regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding;GO:0048712,biological_process negative regulation of astrocyte differentiation	NA	methyl-CpG binding domain protein 1 [Source:HGNC Symbol%3BAcc:HGNC:6916]
ENSG00000152484	14.04	14.54	15.16	14.95	13.78	15.36	-0.00157763219605062	4.04577769431769	1	1	13:27066141-27171896:-	USP12	14;GO:0004197,molecular_function cysteine-type endopeptidase activity;GO:0004843,molecular_function thiol-dependent ubiquitin-specific protease activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005654,cellular_component nucleoplasm;GO:0006508,biological_process proteolysis;GO:0006511,biological_process ubiquitin-dependent protein catabolic process;GO:0008233,molecular_function peptidase activity;GO:0008234,molecular_function cysteine-type peptidase activity;GO:0016579,biological_process protein deubiquitination;GO:0016787,molecular_function hydrolase activity;GO:0036459,molecular_function thiol-dependent ubiquitinyl hydrolase activity;GO:0046872,molecular_function metal ion binding;GO:0101005,molecular_function ubiquitinyl hydrolase activity	NA	ubiquitin specific peptidase 12 [Source:HGNC Symbol%3BAcc:HGNC:20485]
ENSG00000137135	7.16	7.11	6.40	7.45	7.47	5.91	0.00149324256792062	2.86814111056888	1	1	9:35658874-35675866:-	ARHGEF39	8;GO:0005085,molecular_function guanyl-nucleotide exchange factor activity;GO:0005089,molecular_function Rho guanyl-nucleotide exchange factor activity;GO:0005515,molecular_function protein binding;GO:0005886,cellular_component plasma membrane;GO:0016020,cellular_component membrane;GO:0030335,biological_process positive regulation of cell migration;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0043547,biological_process positive regulation of GTPase activity	NA	Rho guanine nucleotide exchange factor 39 [Source:HGNC Symbol%3BAcc:HGNC:25909]
ENSG00000112981	2.55	1.65	2.55	2.12	2.15	2.65	0.00148351806347155	0.696261394842158	1	1	5:138115171-138139443:-	NME5	19;GO:0003351,biological_process epithelial cilium movement;GO:0004550,molecular_function nucleoside diphosphate kinase activity;GO:0005515,molecular_function protein binding;GO:0005575,cellular_component cellular_component;GO:0005622,cellular_component intracellular;GO:0006165,biological_process nucleoside diphosphate phosphorylation;GO:0006183,biological_process GTP biosynthetic process;GO:0006228,biological_process UTP biosynthetic process;GO:0006241,biological_process CTP biosynthetic process;GO:0007275,biological_process multicellular organism development;GO:0007283,biological_process spermatogenesis;GO:0007286,biological_process spermatid development;GO:0009116,biological_process nucleoside metabolic process;GO:0021591,biological_process ventricular system development;GO:0030154,biological_process cell differentiation;GO:0036126,cellular_component sperm flagellum;GO:0048515,biological_process spermatid differentiation;GO:0060271,biological_process cilium morphogenesis;GO:1902176,biological_process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]; K00940	NME/NM23 family member 5 [Source:HGNC Symbol%3BAcc:HGNC:7853]
ENSG00000175643	12.91	11.36	9.02	9.17	10.26	14.01	0.00139653682910531	2.64447118511081	1	1	16:11249618-11351762:+	RMI2	10;GO:0000731,biological_process DNA synthesis involved in DNA repair;GO:0000732,biological_process strand displacement;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006260,biological_process DNA replication;GO:0016607,cellular_component nuclear speck;GO:0033045,biological_process regulation of sister chromatid segregation;GO:1901796,biological_process regulation of signal transduction by p53 class mediator	RMI2; RecQ-mediated genome instability protein 2; K15365	RecQ mediated genome instability 2 [Source:HGNC Symbol%3BAcc:HGNC:28349]
ENSG00000158315	6.52	6.09	5.42	5.68	6.08	6.41	-0.00127651121534562	2.49789903009202	1	1	1:38885806-38941799:-	RHBDL2	9;GO:0004252,molecular_function serine-type endopeptidase activity;GO:0005886,cellular_component plasma membrane;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0008236,molecular_function serine-type peptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016485,biological_process protein processing;GO:0016787,molecular_function hydrolase activity	NA	rhomboid like 2 [Source:HGNC Symbol%3BAcc:HGNC:16083]
ENSG00000184702	5.55	6.39	6.22	5.56	6.02	6.61	0.00119147241048459	3.06850658010937	1	1	22:19714463-19724772:+	SEPT5	19;GO:0000166,molecular_function nucleotide binding;GO:0000910,biological_process cytokinesis;GO:0003924,molecular_function GTPase activity;GO:0005198,molecular_function structural molecule activity;GO:0005515,molecular_function protein binding;GO:0005525,molecular_function GTP binding;GO:0005737,cellular_component cytoplasm;GO:0005856,cellular_component cytoskeleton;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0007049,biological_process cell cycle;GO:0008021,cellular_component synaptic vesicle;GO:0016080,biological_process synaptic vesicle targeting;GO:0017157,biological_process regulation of exocytosis;GO:0043195,cellular_component terminal bouton;GO:0043679,cellular_component axon terminus;GO:0045202,cellular_component synapse;GO:0051301,biological_process cell division;GO:2000300,biological_process regulation of synaptic vesicle exocytosis	SEPT5, PNUTL1, CDCREL1; septin 5; K04557	septin 5 [Source:HGNC Symbol%3BAcc:HGNC:9164]
ENSG00000048405	15.21	13.48	12.71	14.36	13.21	14.19	0.00119056820659393	4.7971514611326	1	1	7:127346789-127431924:-	ZNF800	6;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	NA	zinc finger protein 800 [Source:HGNC Symbol%3BAcc:HGNC:27267]
ENSG00000104884	15.52	17.47	18.42	17.26	18.00	16.57	-0.00116597796926698	5.33043389389938	1	1	19:45349836-45370918:-	ERCC2	81;GO:0000166,molecular_function nucleotide binding;GO:0000439,cellular_component core TFIIH complex;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0001666,biological_process response to hypoxia;GO:0001701,biological_process in utero embryonic development;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005675,cellular_component holo TFIIH complex;GO:0005737,cellular_component cytoplasm;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0006139,biological_process nucleobase-containing compound metabolic process;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0007059,biological_process chromosome segregation;GO:0007568,biological_process aging;GO:0008022,molecular_function protein C-terminus binding;GO:0008026,molecular_function ATP-dependent helicase activity;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008283,biological_process cell proliferation;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0009411,biological_process response to UV;GO:0009650,biological_process UV protection;GO:0009791,biological_process post-embryonic development;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0016818,molecular_function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0019907,cellular_component cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0021510,biological_process spinal cord development;GO:0022405,biological_process hair cycle process;GO:0030198,biological_process extracellular matrix organization;GO:0030282,biological_process bone mineralization;GO:0032289,biological_process central nervous system myelin formation;GO:0032508,biological_process DNA duplex unwinding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0035264,biological_process multicellular organism growth;GO:0035315,biological_process hair cell differentiation;GO:0040016,biological_process embryonic cleavage;GO:0043139,molecular_function 5'-3' DNA helicase activity;GO:0043249,biological_process erythrocyte maturation;GO:0043388,biological_process positive regulation of DNA binding;GO:0043588,biological_process skin development;GO:0045893,biological_process positive regulation of transcription, DNA-templated;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0047485,molecular_function protein N-terminus binding;GO:0048568,biological_process embryonic organ development;GO:0048820,biological_process hair follicle maturation;GO:0051536,molecular_function iron-sulfur cluster binding;GO:0051539,molecular_function 4 iron, 4 sulfur cluster binding;GO:0060218,biological_process hematopoietic stem cell differentiation;GO:0070911,biological_process global genome nucleotide-excision repair;GO:0071817,cellular_component MMXD complex;GO:1901990,biological_process regulation of mitotic cell cycle phase transition	ERCC2, XPD; DNA excision repair protein ERCC-2 [EC:3.6.4.12]; K10844	ERCC excision repair 2%2C TFIIH core complex helicase subunit [Source:HGNC Symbol%3BAcc:HGNC:3434]
ENSG00000119431	15.48	16.88	16.91	13.32	22.76	13.63	-0.00109597586018152	3.64930841893025	1	1	9:113373418-113376999:-	HDHD3	4;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0008152,biological_process metabolic process;GO:0016787,molecular_function hydrolase activity	NA	haloacid dehalogenase like hydrolase domain containing 3 [Source:HGNC Symbol%3BAcc:HGNC:28171]
ENSG00000151148	13.11	12.73	12.11	13.16	11.64	13.46	-0.00108338536889429	5.53729978536666	1	1	12:109477401-109536705:+	UBE3B	6;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005737,cellular_component cytoplasm;GO:0016567,biological_process protein ubiquitination;GO:0016740,molecular_function transferase activity;GO:0016874,molecular_function ligase activity;GO:0061630,molecular_function ubiquitin protein ligase activity	UBE3B; ubiquitin-protein ligase E3 B [EC:2.3.2.26]; K10588	ubiquitin protein ligase E3B [Source:HGNC Symbol%3BAcc:HGNC:13478]
ENSG00000196150	9.14	8.32	8.92	8.72	9.15	8.85	-0.00105021177859574	3.9285794865745	1	1	8:144876496-144902168:-	ZNF250	8;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0003700,molecular_function transcription factor activity, sequence-specific DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 250 [Source:HGNC Symbol%3BAcc:HGNC:13044]
ENSG00000134909	5.16	4.95	5.53	5.40	4.92	5.46	0.00101955873107813	5.06117437157433	1	1	11:128965059-129279324:-	ARHGAP32	27;GO:0000139,cellular_component Golgi membrane;GO:0001650,cellular_component fibrillar center;GO:0005096,molecular_function GTPase activator activity;GO:0005515,molecular_function protein binding;GO:0005654,cellular_component nucleoplasm;GO:0005737,cellular_component cytoplasm;GO:0005768,cellular_component endosome;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005938,cellular_component cell cortex;GO:0007165,biological_process signal transduction;GO:0007264,biological_process small GTPase mediated signal transduction;GO:0010008,cellular_component endosome membrane;GO:0014069,cellular_component postsynaptic density;GO:0015629,cellular_component actin cytoskeleton;GO:0016020,cellular_component membrane;GO:0030054,cellular_component cell junction;GO:0035091,molecular_function phosphatidylinositol binding;GO:0042995,cellular_component cell projection;GO:0043197,cellular_component dendritic spine;GO:0043547,biological_process positive regulation of GTPase activity;GO:0045202,cellular_component synapse;GO:0045211,cellular_component postsynaptic membrane;GO:0051056,biological_process regulation of small GTPase mediated signal transduction	NA	Rho GTPase activating protein 32 [Source:HGNC Symbol%3BAcc:HGNC:17399]
ENSG00000124802	21.76	17.67	21.64	18.70	20.25	22.88	0.00100825607984808	4.26202524312449	1	1	6:8073359-8102578:-	EEF1E1	18;GO:0004364,molecular_function glutathione transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005730,cellular_component nucleolus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006412,biological_process translation;GO:0006418,biological_process tRNA aminoacylation for protein translation;GO:0006749,biological_process glutathione metabolic process;GO:0008285,biological_process negative regulation of cell proliferation;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0017101,cellular_component aminoacyl-tRNA synthetase multienzyme complex;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043517,biological_process positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0070062,cellular_component extracellular exosome;GO:2000774,biological_process positive regulation of cellular senescence	NA	eukaryotic translation elongation factor 1 epsilon 1 [Source:HGNC Symbol%3BAcc:HGNC:3212]
ENSG00000055917	27.52	27.38	30.79	27.29	30.75	28.38	0.000887803027810626	6.54456323378347	1	1	2:20248690-20352234:-	PUM2	16;GO:0003723,molecular_function RNA binding;GO:0003730,molecular_function mRNA 3'-UTR binding;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0006417,biological_process regulation of translation;GO:0010494,cellular_component cytoplasmic stress granule;GO:0010608,biological_process posttranscriptional regulation of gene expression;GO:0031965,cellular_component nuclear membrane;GO:0034063,biological_process stress granule assembly;GO:0043488,biological_process regulation of mRNA stability;GO:0048471,cellular_component perinuclear region of cytoplasm;GO:0051983,biological_process regulation of chromosome segregation;GO:0060964,biological_process regulation of gene silencing by miRNA;GO:1900246,biological_process positive regulation of RIG-I signaling pathway;GO:2000637,biological_process positive regulation of gene silencing by miRNA	NA	pumilio RNA binding family member 2 [Source:HGNC Symbol%3BAcc:HGNC:14958]
ENSG00000148291	8.37	8.21	9.39	8.09	8.69	9.43	0.000882431476680927	2.77598292894866	1	1	9:133356551-133361169:+	SURF2	7;GO:0003674,molecular_function molecular_function;GO:0005575,cellular_component cellular_component;GO:0005634,cellular_component nucleus;GO:0005730,cellular_component nucleolus;GO:0005886,cellular_component plasma membrane;GO:0008150,biological_process biological_process;GO:0016607,cellular_component nuclear speck	NA	surfeit 2 [Source:HGNC Symbol%3BAcc:HGNC:11475]
ENSG00000239713	10.05	8.88	12.08	11.57	8.03	11.78	-0.000882215547387906	3.60848917310438	1	1	22:39077004-39087743:+	APOBEC3G	29;GO:0000932,cellular_component cytoplasmic mRNA processing body;GO:0002230,biological_process positive regulation of defense response to virus by host;GO:0002376,biological_process immune system process;GO:0003723,molecular_function RNA binding;GO:0003824,molecular_function catalytic activity;GO:0004126,molecular_function cytidine deaminase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0008270,molecular_function zinc ion binding;GO:0008829,molecular_function dCTP deaminase activity;GO:0009972,biological_process cytidine deamination;GO:0010529,biological_process negative regulation of transposition;GO:0016032,biological_process viral process;GO:0016553,biological_process base conversion or substitution editing;GO:0016787,molecular_function hydrolase activity;GO:0016814,molecular_function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0030529,cellular_component intracellular ribonucleoprotein complex;GO:0030895,cellular_component apolipoprotein B mRNA editing enzyme complex;GO:0042803,molecular_function protein homodimerization activity;GO:0045071,biological_process negative regulation of viral genome replication;GO:0045087,biological_process innate immune response;GO:0045869,biological_process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0046872,molecular_function metal ion binding;GO:0047844,molecular_function deoxycytidine deaminase activity;GO:0048525,biological_process negative regulation of viral process;GO:0051607,biological_process defense response to virus;GO:0070383,biological_process DNA cytosine deamination	NA	apolipoprotein B mRNA editing enzyme catalytic subunit 3G [Source:HGNC Symbol%3BAcc:HGNC:17357]
ENSG00000132155	40.85	43.87	42.93	45.06	41.48	42.11	-0.000714541525823297	6.42254371097316	1	1	3:12583600-12664226:-	RAF1	67;GO:0000165,biological_process MAPK cascade;GO:0000166,molecular_function nucleotide binding;GO:0000186,biological_process activation of MAPKK activity;GO:0001666,biological_process response to hypoxia;GO:0001678,biological_process cellular glucose homeostasis;GO:0001934,biological_process positive regulation of protein phosphorylation;GO:0002223,biological_process stimulatory C-type lectin receptor signaling pathway;GO:0004672,molecular_function protein kinase activity;GO:0004674,molecular_function protein serine/threonine kinase activity;GO:0004709,molecular_function MAP kinase kinase kinase activity;GO:0005057,molecular_function receptor signaling protein activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005739,cellular_component mitochondrion;GO:0005741,cellular_component mitochondrial outer membrane;GO:0005794,cellular_component Golgi apparatus;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0007165,biological_process signal transduction;GO:0007190,biological_process activation of adenylate cyclase activity;GO:0007275,biological_process multicellular organism development;GO:0007507,biological_process heart development;GO:0008283,biological_process cell proliferation;GO:0008285,biological_process negative regulation of cell proliferation;GO:0009968,biological_process negative regulation of signal transduction;GO:0016020,cellular_component membrane;GO:0016301,molecular_function kinase activity;GO:0016310,biological_process phosphorylation;GO:0016607,cellular_component nuclear speck;GO:0016740,molecular_function transferase activity;GO:0017016,molecular_function Ras GTPase binding;GO:0019899,molecular_function enzyme binding;GO:0030154,biological_process cell differentiation;GO:0030168,biological_process platelet activation;GO:0030878,biological_process thyroid gland development;GO:0031143,cellular_component pseudopodium;GO:0031333,biological_process negative regulation of protein complex assembly;GO:0031434,molecular_function mitogen-activated protein kinase kinase binding;GO:0033138,biological_process positive regulation of peptidyl-serine phosphorylation;GO:0034220,biological_process ion transmembrane transport;GO:0035019,biological_process somatic stem cell population maintenance;GO:0035023,biological_process regulation of Rho protein signal transduction;GO:0035556,biological_process intracellular signal transduction;GO:0035773,biological_process insulin secretion involved in cellular response to glucose stimulus;GO:0035994,biological_process response to muscle stretch;GO:0042060,biological_process wound healing;GO:0042802,molecular_function identical protein binding;GO:0042981,biological_process regulation of apoptotic process;GO:0043066,biological_process negative regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045104,biological_process intermediate filament cytoskeleton organization;GO:0045595,biological_process regulation of cell differentiation;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0046872,molecular_function metal ion binding;GO:0046982,molecular_function protein heterodimerization activity;GO:0048011,biological_process neurotrophin TRK receptor signaling pathway;GO:0048538,biological_process thymus development;GO:0060324,biological_process face development;GO:0070374,biological_process positive regulation of ERK1 and ERK2 cascade;GO:0071550,biological_process death-inducing signaling complex assembly;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000145,biological_process regulation of cell motility	RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]; K04366	Raf-1 proto-oncogene%2C serine/threonine kinase [Source:HGNC Symbol%3BAcc:HGNC:9829]
ENSG00000092036	20.76	20.67	21.97	19.27	21.62	23.06	-0.000664167316845136	4.58109533284623	1	1	14:22946227-22957161:-	HAUS4	16;GO:0000086,biological_process G2/M transition of mitotic cell cycle;GO:0003674,molecular_function molecular_function;GO:0005737,cellular_component cytoplasm;GO:0005813,cellular_component centrosome;GO:0005815,cellular_component microtubule organizing center;GO:0005819,cellular_component spindle;GO:0005829,cellular_component cytosol;GO:0005856,cellular_component cytoskeleton;GO:0005874,cellular_component microtubule;GO:0007049,biological_process cell cycle;GO:0007098,biological_process centrosome cycle;GO:0010389,biological_process regulation of G2/M transition of mitotic cell cycle;GO:0051225,biological_process spindle assembly;GO:0051301,biological_process cell division;GO:0070652,cellular_component HAUS complex;GO:0097711,biological_process ciliary basal body-plasma membrane docking	NA	HAUS augmin like complex subunit 4 [Source:HGNC Symbol%3BAcc:HGNC:20163]
ENSG00000104689	4.88	4.36	5.03	4.80	4.65	5.01	0.000643371018992905	2.78624454096631	1	1	8:23190451-23225126:-	TNFRSF10A	34;GO:0002020,molecular_function protease binding;GO:0004872,molecular_function receptor activity;GO:0005031,molecular_function tumor necrosis factor-activated receptor activity;GO:0005035,molecular_function death receptor activity;GO:0005515,molecular_function protein binding;GO:0005622,cellular_component intracellular;GO:0005886,cellular_component plasma membrane;GO:0005887,cellular_component integral component of plasma membrane;GO:0006915,biological_process apoptotic process;GO:0006919,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954,biological_process inflammatory response;GO:0006955,biological_process immune response;GO:0007165,biological_process signal transduction;GO:0007166,biological_process cell surface receptor signaling pathway;GO:0007250,biological_process activation of NF-kappaB-inducing kinase activity;GO:0007275,biological_process multicellular organism development;GO:0008134,molecular_function transcription factor binding;GO:0008625,biological_process extrinsic apoptotic signaling pathway via death domain receptors;GO:0009986,cellular_component cell surface;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0032496,biological_process response to lipopolysaccharide;GO:0033209,biological_process tumor necrosis factor-mediated signaling pathway;GO:0036462,biological_process TRAIL-activated apoptotic signaling pathway;GO:0042127,biological_process regulation of cell proliferation;GO:0042981,biological_process regulation of apoptotic process;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045569,molecular_function TRAIL binding;GO:0050900,biological_process leukocyte migration;GO:0071260,biological_process cellular response to mechanical stimulus;GO:0097191,biological_process extrinsic apoptotic signaling pathway;GO:0097296,biological_process activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1902041,biological_process regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902042,biological_process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B; K04722	TNF receptor superfamily member 10a [Source:HGNC Symbol%3BAcc:HGNC:11904]
ENSG00000124767	161.34	168.80	165.07	170.77	164.05	164.33	-0.000629002369255522	6.51835432679951	1	1	6:38675924-38703141:-	GLO1	16;GO:0004462,molecular_function lactoylglutathione lyase activity;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005886,cellular_component plasma membrane;GO:0005975,biological_process carbohydrate metabolic process;GO:0006090,biological_process pyruvate metabolic process;GO:0006357,biological_process regulation of transcription from RNA polymerase II promoter;GO:0006749,biological_process glutathione metabolic process;GO:0008270,molecular_function zinc ion binding;GO:0009438,biological_process methylglyoxal metabolic process;GO:0016829,molecular_function lyase activity;GO:0030316,biological_process osteoclast differentiation;GO:0043066,biological_process negative regulation of apoptotic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome	GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]; K01759	glyoxalase I [Source:HGNC Symbol%3BAcc:HGNC:4323]
ENSG00000162430	24.78	25.92	25.29	25.94	26.74	23.93	-0.000620533330586895	5.50615422790526	1	1	1:25800175-25818224:+	SELENON	13;GO:0003674,molecular_function molecular_function;GO:0005509,molecular_function calcium ion binding;GO:0005515,molecular_function protein binding;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0008150,biological_process biological_process;GO:0016020,cellular_component membrane;GO:0016491,molecular_function oxidoreductase activity;GO:0048741,biological_process skeletal muscle fiber development;GO:0055074,biological_process calcium ion homeostasis;GO:0055114,biological_process oxidation-reduction process;GO:0060314,biological_process regulation of ryanodine-sensitive calcium-release channel activity;GO:1902884,biological_process positive regulation of response to oxidative stress	NA	selenoprotein N [Source:HGNC Symbol%3BAcc:HGNC:15999]
ENSG00000084073	39.20	37.62	38.69	39.14	39.81	37.60	0.000610496913442672	5.78962126034064	1	1	1:40258106-40294184:+	ZMPSTE24	19;GO:0004222,molecular_function metalloendopeptidase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005637,cellular_component nuclear inner membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006508,biological_process proteolysis;GO:0006998,biological_process nuclear envelope organization;GO:0008233,molecular_function peptidase activity;GO:0008235,molecular_function metalloexopeptidase activity;GO:0008237,molecular_function metallopeptidase activity;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016787,molecular_function hydrolase activity;GO:0030176,cellular_component integral component of endoplasmic reticulum membrane;GO:0030327,biological_process prenylated protein catabolic process;GO:0046872,molecular_function metal ion binding;GO:0070062,cellular_component extracellular exosome;GO:0071586,biological_process CAAX-box protein processing	STE24; STE24 endopeptidase [EC:3.4.24.84]; K06013	zinc metallopeptidase STE24 [Source:HGNC Symbol%3BAcc:HGNC:12877]
ENSG00000204524	1.99	1.68	1.88	2.15	1.33	2.13	-0.000604598097103027	1.87605207832099	1	1	19:57240684-57255135:+	ZNF805	7;GO:0003676,molecular_function nucleic acid binding;GO:0003677,molecular_function DNA binding;GO:0005622,cellular_component intracellular;GO:0005634,cellular_component nucleus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0046872,molecular_function metal ion binding	KRAB; KRAB domain-containing zinc finger protein; K09228	zinc finger protein 805 [Source:HGNC Symbol%3BAcc:HGNC:23272]
ENSG00000105518	155.45	153.38	172.51	166.78	152.09	166.56	0.000523694901486569	6.5174385986361	1	1	19:11342775-11346518:-	TMEM205	3;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0070062,cellular_component extracellular exosome	NA	transmembrane protein 205 [Source:HGNC Symbol%3BAcc:HGNC:29631]
ENSG00000089289	142.02	134.84	139.75	139.29	141.92	138.91	0.000509391710107634	7.15070923006958	1	1	X:70133448-70166324:+	IGBP1	15;GO:0000122,biological_process negative regulation of transcription from RNA polymerase II promoter;GO:0005515,molecular_function protein binding;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0007165,biological_process signal transduction;GO:0009966,biological_process regulation of signal transduction;GO:0019888,molecular_function protein phosphatase regulator activity;GO:0032873,biological_process negative regulation of stress-activated MAPK cascade;GO:0034612,biological_process response to tumor necrosis factor;GO:0035303,biological_process regulation of dephosphorylation;GO:0042113,biological_process B cell activation;GO:0043154,biological_process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0051721,molecular_function protein phosphatase 2A binding;GO:0060632,biological_process regulation of microtubule-based movement;GO:0070555,biological_process response to interleukin-1	NA	immunoglobulin binding protein 1 [Source:HGNC Symbol%3BAcc:HGNC:5461]
ENSG00000136867	9.23	8.72	10.23	8.39	10.54	9.63	-0.0004838352513243	2.23978772425818	1	1	9:113150941-113164137:+	SLC31A2	12;GO:0005375,molecular_function copper ion transmembrane transporter activity;GO:0005770,cellular_component late endosome;GO:0005887,cellular_component integral component of plasma membrane;GO:0006810,biological_process transport;GO:0006811,biological_process ion transport;GO:0006825,biological_process copper ion transport;GO:0006878,biological_process cellular copper ion homeostasis;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0035434,biological_process copper ion transmembrane transport;GO:0055037,cellular_component recycling endosome;GO:1902311,biological_process regulation of copper ion transmembrane transport	NA	solute carrier family 31 member 2 [Source:HGNC Symbol%3BAcc:HGNC:11017]
ENSG00000130770	223.91	207.90	230.40	215.42	218.59	234.22	0.000408953344191275	6.47149897547334	1	1	1:28236108-28246906:+	ATPIF1	26;GO:0001525,biological_process angiogenesis;GO:0001937,biological_process negative regulation of endothelial cell proliferation;GO:0004857,molecular_function enzyme inhibitor activity;GO:0005516,molecular_function calmodulin binding;GO:0005739,cellular_component mitochondrion;GO:0005753,cellular_component mitochondrial proton-transporting ATP synthase complex;GO:0006091,biological_process generation of precursor metabolites and energy;GO:0006783,biological_process heme biosynthetic process;GO:0009986,cellular_component cell surface;GO:0019899,molecular_function enzyme binding;GO:0030218,biological_process erythrocyte differentiation;GO:0032780,biological_process negative regulation of ATPase activity;GO:0042030,molecular_function ATPase inhibitor activity;GO:0042803,molecular_function protein homodimerization activity;GO:0043532,molecular_function angiostatin binding;GO:0051117,molecular_function ATPase binding;GO:0051260,biological_process protein homooligomerization;GO:0051289,biological_process protein homotetramerization;GO:0051346,biological_process negative regulation of hydrolase activity;GO:0051882,biological_process mitochondrial depolarization;GO:0072593,biological_process reactive oxygen species metabolic process;GO:1901030,biological_process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1903052,biological_process positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903214,biological_process regulation of protein targeting to mitochondrion;GO:1903578,biological_process regulation of ATP metabolic process;GO:1904925,biological_process positive regulation of mitophagy in response to mitochondrial depolarization	NA	ATPase inhibitory factor 1 [Source:HGNC Symbol%3BAcc:HGNC:871]
ENSG00000163161	26.16	26.15	24.18	24.42	26.61	26.05	-0.000390563702958796	6.03266144910464	1	1	2:127257289-127294176:-	ERCC3	58;GO:0000166,molecular_function nucleotide binding;GO:0000439,cellular_component core TFIIH complex;GO:0000717,biological_process nucleotide-excision repair, DNA duplex unwinding;GO:0001666,biological_process response to hypoxia;GO:0003677,molecular_function DNA binding;GO:0003684,molecular_function damaged DNA binding;GO:0004003,molecular_function ATP-dependent DNA helicase activity;GO:0004386,molecular_function helicase activity;GO:0004672,molecular_function protein kinase activity;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005525,molecular_function GTP binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005669,cellular_component transcription factor TFIID complex;GO:0005675,cellular_component holo TFIIH complex;GO:0006265,biological_process DNA topological change;GO:0006281,biological_process DNA repair;GO:0006283,biological_process transcription-coupled nucleotide-excision repair;GO:0006289,biological_process nucleotide-excision repair;GO:0006293,biological_process nucleotide-excision repair, preincision complex stabilization;GO:0006294,biological_process nucleotide-excision repair, preincision complex assembly;GO:0006295,biological_process nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,biological_process nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006361,biological_process transcription initiation from RNA polymerase I promoter;GO:0006362,biological_process transcription elongation from RNA polymerase I promoter;GO:0006363,biological_process termination of RNA polymerase I transcription;GO:0006366,biological_process transcription from RNA polymerase II promoter;GO:0006367,biological_process transcription initiation from RNA polymerase II promoter;GO:0006368,biological_process transcription elongation from RNA polymerase II promoter;GO:0006370,biological_process 7-methylguanosine mRNA capping;GO:0006468,biological_process protein phosphorylation;GO:0006915,biological_process apoptotic process;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0006979,biological_process response to oxidative stress;GO:0008022,molecular_function protein C-terminus binding;GO:0008094,molecular_function DNA-dependent ATPase activity;GO:0008104,biological_process protein localization;GO:0008134,molecular_function transcription factor binding;GO:0008353,molecular_function RNA polymerase II carboxy-terminal domain kinase activity;GO:0009411,biological_process response to UV;GO:0009650,biological_process UV protection;GO:0016032,biological_process viral process;GO:0016787,molecular_function hydrolase activity;GO:0016887,molecular_function ATPase activity;GO:0032564,molecular_function dATP binding;GO:0033683,biological_process nucleotide-excision repair, DNA incision;GO:0035315,biological_process hair cell differentiation;GO:0042277,molecular_function peptide binding;GO:0043065,biological_process positive regulation of apoptotic process;GO:0043138,molecular_function 3'-5' DNA helicase activity;GO:0045944,biological_process positive regulation of transcription from RNA polymerase II promoter;GO:0047485,molecular_function protein N-terminus binding;GO:0048568,biological_process embryonic organ development;GO:0070911,biological_process global genome nucleotide-excision repair;GO:1901990,biological_process regulation of mitotic cell cycle phase transition	ERCC3, XPB; DNA excision repair protein ERCC-3 [EC:3.6.4.12]; K10843	ERCC excision repair 3%2C TFIIH core complex helicase subunit [Source:HGNC Symbol%3BAcc:HGNC:3435]
ENSG00000171224	9.82	11.14	9.93	10.56	8.69	11.65	-0.000390209919234281	2.37351791712059	1	1	10:69630250-69633599:+	C10orf35	3;GO:0005515,molecular_function protein binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane	NA	chromosome 10 open reading frame 35 [Source:HGNC Symbol%3BAcc:HGNC:23519]
ENSG00000124587	27.93	25.53	24.21	26.47	27.13	24.75	0.000370205758045288	6.27062278075122	1	1	6:42963869-42979220:-	PEX6	19;GO:0000166,molecular_function nucleotide binding;GO:0001750,cellular_component photoreceptor outer segment;GO:0005515,molecular_function protein binding;GO:0005524,molecular_function ATP binding;GO:0005737,cellular_component cytoplasm;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005829,cellular_component cytosol;GO:0006625,biological_process protein targeting to peroxisome;GO:0007031,biological_process peroxisome organization;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0016561,biological_process protein import into peroxisome matrix, translocation;GO:0016887,molecular_function ATPase activity;GO:0032403,molecular_function protein complex binding;GO:0042623,molecular_function ATPase activity, coupled;GO:0042995,cellular_component cell projection;GO:0050821,biological_process protein stabilization;GO:0097733,cellular_component photoreceptor cell cilium	PEX6, PXAAA1; peroxin-6; K13339	peroxisomal biogenesis factor 6 [Source:HGNC Symbol%3BAcc:HGNC:8859]
ENSG00000143363	10.60	10.69	10.78	10.85	10.77	10.71	-0.000360710788249072	3.88227529382087	1	1	1:151008419-151035713:+	PRUNE1	15;GO:0004427,molecular_function inorganic diphosphatase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005829,cellular_component cytosol;GO:0005925,cellular_component focal adhesion;GO:0015631,molecular_function tubulin binding;GO:0016311,biological_process dephosphorylation;GO:0016462,molecular_function pyrophosphatase activity;GO:0016787,molecular_function hydrolase activity;GO:0016791,molecular_function phosphatase activity;GO:0030054,cellular_component cell junction;GO:0031113,biological_process regulation of microtubule polymerization;GO:0046872,molecular_function metal ion binding;GO:0050767,biological_process regulation of neurogenesis	PRUNE, PPX1; exopolyphosphatase [EC:3.6.1.11]; K01514	prune exopolyphosphatase 1 [Source:HGNC Symbol%3BAcc:HGNC:13420]
ENSG00000171103	15.55	15.69	15.89	13.81	17.12	16.56	0.000355624010897731	4.50685440942237	1	1	2:28849820-28870301:-	TRMT61B	14;GO:0005515,molecular_function protein binding;GO:0005739,cellular_component mitochondrion;GO:0005759,cellular_component mitochondrial matrix;GO:0008033,biological_process tRNA processing;GO:0008168,molecular_function methyltransferase activity;GO:0016429,molecular_function tRNA (adenine-N1-)-methyltransferase activity;GO:0016433,molecular_function rRNA (adenine) methyltransferase activity;GO:0016740,molecular_function transferase activity;GO:0030488,biological_process tRNA methylation;GO:0031167,biological_process rRNA methylation;GO:0031515,cellular_component tRNA (m1A) methyltransferase complex;GO:0032259,biological_process methylation;GO:0051260,biological_process protein homooligomerization;GO:0070901,biological_process mitochondrial tRNA methylation	NA	tRNA methyltransferase 61B [Source:HGNC Symbol%3BAcc:HGNC:26070]
ENSG00000183684	40.04	40.54	34.66	35.83	41.27	38.89	-0.000314039443074908	4.93836706285091	1	1	17:81887843-81891586:-	ALYREF	3;GO:0003676,molecular_function nucleic acid binding;GO:0003723,molecular_function RNA binding;GO:0016607,cellular_component nuclear speck	THOC4, ALY; THO complex subunit 4; K12881	Aly/REF export factor [Source:HGNC Symbol%3BAcc:HGNC:19071]
ENSG00000121064	16.00	16.39	16.78	17.68	16.18	15.72	0.000278919477380077	4.49879693464331	1	1	17:56978104-57006768:+	SCPEP1	12;GO:0004180,molecular_function carboxypeptidase activity;GO:0004185,molecular_function serine-type carboxypeptidase activity;GO:0005576,cellular_component extracellular region;GO:0005829,cellular_component cytosol;GO:0006508,biological_process proteolysis;GO:0008233,molecular_function peptidase activity;GO:0016787,molecular_function hydrolase activity;GO:0042573,biological_process retinoic acid metabolic process;GO:0045776,biological_process negative regulation of blood pressure;GO:0051603,biological_process proteolysis involved in cellular protein catabolic process;GO:0070062,cellular_component extracellular exosome;GO:0097755,biological_process positive regulation of blood vessel diameter	NA	serine carboxypeptidase 1 [Source:HGNC Symbol%3BAcc:HGNC:29507]
ENSG00000125741	2.95	2.86	3.15	2.56	3.57	2.93	-0.000238122591292137	1.567529382366	1	1	19:45527426-45602212:-	OPA3	7;GO:0005739,cellular_component mitochondrion;GO:0007601,biological_process visual perception;GO:0019216,biological_process regulation of lipid metabolic process;GO:0040007,biological_process growth;GO:0050896,biological_process response to stimulus;GO:0050905,biological_process neuromuscular process;GO:0070584,biological_process mitochondrion morphogenesis	NA	OPA3%2C outer mitochondrial membrane lipid metabolism regulator [Source:HGNC Symbol%3BAcc:HGNC:8142]
ENSG00000157212	9.90	9.60	9.10	9.99	9.33	9.49	0.000206559228584107	4.99948267423131	1	1	7:154943686-155003084:-	PAXIP1	29;GO:0000416,biological_process positive regulation of histone H3-K36 methylation;GO:0001570,biological_process vasculogenesis;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005694,cellular_component chromosome;GO:0006281,biological_process DNA repair;GO:0006303,biological_process double-strand break repair via nonhomologous end joining;GO:0006310,biological_process DNA recombination;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0006974,biological_process cellular response to DNA damage stimulus;GO:0010212,biological_process response to ionizing radiation;GO:0016363,cellular_component nuclear matrix;GO:0030330,biological_process DNA damage response, signal transduction by p53 class mediator;GO:0031398,biological_process positive regulation of protein ubiquitination;GO:0035066,biological_process positive regulation of histone acetylation;GO:0035097,cellular_component histone methyltransferase complex;GO:0043542,biological_process endothelial cell migration;GO:0044666,cellular_component MLL3/4 complex;GO:0045830,biological_process positive regulation of isotype switching;GO:0048304,biological_process positive regulation of isotype switching to IgG isotypes;GO:0051568,biological_process histone H3-K4 methylation;GO:0051571,biological_process positive regulation of histone H3-K4 methylation;GO:0060261,biological_process positive regulation of transcription initiation from RNA polymerase II promoter;GO:0060612,biological_process adipose tissue development;GO:0060717,biological_process chorion development;GO:1902749,biological_process regulation of cell cycle G2/M phase transition;GO:2001022,biological_process positive regulation of response to DNA damage stimulus	NA	PAX interacting protein 1 [Source:HGNC Symbol%3BAcc:HGNC:8624]
ENSG00000121680	11.25	10.20	11.08	9.24	11.29	12.32	-0.000186474575543164	3.79461941342575	1	1	11:45909668-45918812:-	PEX16	17;GO:0005515,molecular_function protein binding;GO:0005777,cellular_component peroxisome;GO:0005778,cellular_component peroxisomal membrane;GO:0005779,cellular_component integral component of peroxisomal membrane;GO:0005783,cellular_component endoplasmic reticulum;GO:0005789,cellular_component endoplasmic reticulum membrane;GO:0006625,biological_process protein targeting to peroxisome;GO:0007031,biological_process peroxisome organization;GO:0008022,molecular_function protein C-terminus binding;GO:0016020,cellular_component membrane;GO:0016021,cellular_component integral component of membrane;GO:0016557,biological_process peroxisome membrane biogenesis;GO:0016558,biological_process protein import into peroxisome matrix;GO:0022615,biological_process protein to membrane docking;GO:0032581,biological_process ER-dependent peroxisome organization;GO:0045046,biological_process protein import into peroxisome membrane;GO:0070972,biological_process protein localization to endoplasmic reticulum	PEX16; peroxin-16; K13335	peroxisomal biogenesis factor 16 [Source:HGNC Symbol%3BAcc:HGNC:8857]
ENSG00000114439	16.55	16.88	18.06	16.74	17.75	17.44	8.2973189068317e-05	5.68962730938293	1	1	3:107522935-107811324:+	BBX	7;GO:0003677,molecular_function DNA binding;GO:0005634,cellular_component nucleus;GO:0005654,cellular_component nucleoplasm;GO:0005829,cellular_component cytosol;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0060348,biological_process bone development	NA	BBX%2C HMG-box containing [Source:HGNC Symbol%3BAcc:HGNC:14422]
ENSG00000085382	7.07	6.88	7.10	7.12	6.73	7.38	6.1948489261523e-05	4.32488786621299	1	1	6:104728092-104859919:-	HACE1	23;GO:0000139,cellular_component Golgi membrane;GO:0004842,molecular_function ubiquitin-protein transferase activity;GO:0005515,molecular_function protein binding;GO:0005634,cellular_component nucleus;GO:0005737,cellular_component cytoplasm;GO:0005783,cellular_component endoplasmic reticulum;GO:0005794,cellular_component Golgi apparatus;GO:0006351,biological_process transcription, DNA-templated;GO:0006355,biological_process regulation of transcription, DNA-templated;GO:0007030,biological_process Golgi organization;GO:0007049,biological_process cell cycle;GO:0016020,cellular_component membrane;GO:0016567,biological_process protein ubiquitination;GO:0016601,biological_process Rac protein signal transduction;GO:0016740,molecular_function transferase activity;GO:0017137,molecular_function Rab GTPase binding;GO:0030334,biological_process regulation of cell migration;GO:0032580,cellular_component Golgi cisterna membrane;GO:0042787,biological_process protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0048365,molecular_function Rac GTPase binding;GO:0061025,biological_process membrane fusion;GO:0061630,molecular_function ubiquitin protein ligase activity;GO:0070936,biological_process protein K48-linked ubiquitination	NA	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol%3BAcc:HGNC:21033]